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<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI97</accession>
    <name>S0DI97_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_01612</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423971.1">
        <property type="nucleotide sequence ID" value="XM_023576772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI97"/>
    <dbReference type="STRING" id="1279085.S0DI97"/>
    <dbReference type="GeneID" id="35395097"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01612"/>
    <dbReference type="HOGENOM" id="CLU_013615_8_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494870" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT61890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="195" mass="20492" checksum="FC2EDB31D0507E5F" modified="2013-09-18" version="1">MKAALLLSALASAAIGVVAEDLKIDVTLPVVCDRKTKKGDRVQMHYRGTLKDSGEQFDASYDRGTPLDFVVGSGQVIRGWDEGLLDMCIGEKRLLTIPPEYGYGQRAIGPIPAGSTLVFETELVGIQGVPKPEKIETKVVEGAETAAEAISEAVESAASATKNVAGKVAQAVVDAADAAKTIIADTDDAPEHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIV8</accession>
    <name>S0DIV8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable sulfate permease SutB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_01260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424291.1">
        <property type="nucleotide sequence ID" value="XM_023580706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIV8"/>
    <dbReference type="STRING" id="1279085.S0DIV8"/>
    <dbReference type="GeneID" id="35394745"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01260"/>
    <dbReference type="HOGENOM" id="CLU_003182_8_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="573"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="820" mass="89176" checksum="D972900FF4CD627D" modified="2013-09-18" version="1">MLGHTNPLGRGVANILGIKLEDQKQGLQAEIPSSSSIASEQRHNSFYETEPTSSEWIKEQVPSKEEVVAYAASLFPFASWISHYNMQWFAGDLVAGITIGAVVVPQGMAYAILANLEPQFGLYSSFIGALIYWIFGTSKDISIGPVAVLSTVVGNVVQDVQDSEQNVQAHVVASALSVIAGFIVLVIGLLRCGWIVDLISVTSLSAFMTGSAITICIGQLPALLGLSGFSNRDPPYKVFANTIEHLGEAGYDAVVGVSALSILYLIRQGFTAAAERYPKLKRLLFFTNTMRTVFVILVYTVMSWVLNMHRKDDPLFKVLGVIPKGFQNIGVPRLTTELISDFIPYLPATVIVLLVEHMAISKSFGRVNNYTIDPSQEMVAIGMANLVGPFLGAYPATGSFSRTAIQSKAGVRTPAAGIITGLVVLLATYLLTAVFFYIPSAALAAVIIHAVGDLVTPPNTIYQFWRVSPIEVFIFFTGVIVSVFAQIEDGLYATVLLSGAVFIYRILKAKGRFLGKVKVRSVIGDHVIGDDHRKVVGEYGTIEDSDVSARNVFIPLGHGDGSNPEVEVDHPYPGIFIYRFSEGFNYPNANSSLDYLTDFIQSNTQRSSPEAFERPGDRPWNNPGPRKSAKRPVNSDPDSALPTLKAIILDFSSVNNVDITSIQRLIDIRNQLDSYASPDGVDWHFACINNRWSKRALVSAGFGVPYKPNEGTAPRRWKSIFSVAEIGGKDSAAAIAQETDPDEMTPKHMDNTGEEPLIGGFSSVKSYGSVSSGDLEKQKRRGAVVHGLDKPLFHVDLTSALQNAITNVEERTISRETAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIY3</accession>
    <name>S0DIY3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424252.1">
        <property type="nucleotide sequence ID" value="XM_023580228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIY3"/>
    <dbReference type="GeneID" id="35394788"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01303"/>
    <dbReference type="HOGENOM" id="CLU_121052_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="194" mass="22103" checksum="C3FFC8CA05CFEEC0" modified="2013-09-18" version="1">MRTIHSSGTDIKAIKCSIYVRFPLLDQESLTTTSKLCKKIISMCVYGRVVFKCAHERWGICVKQCQTAKDFRDGKLNHDCVIKKPHVPTSRRIQTNCNKCITLDGKLDRAKKSIDDVKQKLKRIEERKIRKRNTEENKIDNRKKVEKKDENRDSNETNSWSFGTGLGSITEESEVEDESSSDGSSQGSSQVTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ93</accession>
    <name>S0DJ93_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">FFUJ_00886</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJ93"/>
    <dbReference type="STRING" id="1279085.S0DJ93"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00886"/>
    <dbReference type="HOGENOM" id="CLU_009665_8_0_1"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="38"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT62554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="487" mass="52906" checksum="25FE03B83CE8A846" modified="2013-09-18" version="1">MLARKSVLGKPGFVCRSCVRQYQYQLRRASTSAQDNIYDVVCVGGGPAGLSLLTALRANPLTAGLRVALIEAQDLSKTKSFSLPLTQFSNRCSSLTPASAQYLDKIGAWRHLQRERVQDYQEMQVWDGVTGARIEFDWPPSTTGDKTIAYMAENLNLTSGLLKRLQELGGVDVFDKTKVEGIELGKETEELDLSEWPVVQLSSGQSLAARLLVGADGANSPVRTFAGINSRGWDYGRHGVVATLELEGEGWGGQFNKIAYQRFLPTGPVAMLPMPGKYATLVWSTTPEKAALLKSLSPKDFIAMVNAAFRLSPVDIGFMHSQENNQAEELSWRLQHTHVDAESLPQTVAGVQEGSVASFPLKLRHADTYTGERVALVGDAAHTIHPLAGQGLNQGQGDAQSLAKTIEYAVSHGQDLGTQLSLEPYNSERYAANHVILNVCDKLHKLYSVESGPLVPLRSVGLRAVNALGPLKNFFMEQASGTGTKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJI2</accession>
    <name>S0DJI2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424561.1">
        <property type="nucleotide sequence ID" value="XM_023569163.1"/>
    </dbReference>
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            <begin position="1"/>
            <end position="36"/>
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        </location>
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            <end position="214"/>
        </location>
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            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
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            <end position="162"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="300" mass="32928" checksum="FA72D3A4400D9B58" modified="2013-09-18" version="1">MSLSRAFTTRKAKMAGQTEMGEQQVQVPHRSNSARDRQHPILRHQISAPLQLVHTTNMLSYNAPDIPHAALRSKSSLRSVGEESEAPSTTESTPPTSPDVSPVEECPGPKPNHLSTYFSVSDKPAVLSKISEAPAIPKRSPSHTKQNSYEALARQRSTSQMSRDSEHSVSTKASFTFSRSSSTSTRASSASYVSASQAQKAPPMPVPAVPAVAPVPPPSFQQRVLKDSHPFGHELAQVTELAEEYSTRPTSKEDEEDHRFMKSRGLNKFSPEDYLSDVQSLILSFFPEVSHAKPTTPQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKF2</accession>
    <name>S0DKF2_GIBF5</name>
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        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023573189.1"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
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        <property type="entry name" value="DUF7721"/>
    </dbReference>
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        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="82"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="245" mass="25835" checksum="384AA761AB27CDF6" modified="2013-09-18" version="1">MDKLINAAKDYLDDDKDKRQEHQQQGHGQQQGYGGQDQGYGQQQGYGQQEGQYGQQQQYPPAGGIQSQGGGGFSSFLGGNVDFDNAKEEAHQKAGSSGDKDLFGSILGSLGQKQNKLADEDLDEEDAIKQHKNTYNDDDSQQDSKSLGTAAAMQALKMFTQGQGQSSTGANSQTAFLGLALAEASKLFDNKAASGKVSEGTSKESVIQQAGEVAFKMYLKNQAGAGGQQGGASGLMSLASKFLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKJ9</accession>
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        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
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    </protein>
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        <name evidence="12" type="ORF">FFUJ_01610</name>
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    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
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    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
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        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
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        <property type="entry name" value="Rad18_UBZ4"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRK02406.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="134"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="483"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="599"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="605"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT61892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="640" mass="72880" checksum="8AA1D999164B7547" modified="2013-09-18" version="1">MSSTDQAEEQPPLQPTEEHSGAEKETNHVNRDTSETAEDDAFKTLKYSLLGPSLLKAGQDTVDQIKVSEIIYNASKGSKFFNREEERDKVLTQKIEQIIARKAQLEKRDLTRDLRNADRLIAELELTRDLTQHIVHVDCDAFYAAVEQLDRPEIKDLPFAVGGGVLTTCNYVARKFGCRSGMAGFVAKKLCPSLILLKPNFQKYNAKAHEVREVLVNYDPRFESASIDEAYLNITEYCQEHQMDPAEAVEQMRREVHEKTNITVSAGIAANAKLAKICSNMNKPNGQYVLSCDRPTIMAFMRDLPTRKVNGIGRVLERELLEIGIKTCGDLYKHRQYLNPLFGDKTSEFLFTCYLGLGRTKIQPAEEYERKSVGTESTFRDMSDPTQLREKLRATAEELEQDMKRAECKGRTLCLKVKLHTFEVFTRQVVLPRAICLADDLYNYALPILTKLEQEMPGMKLRLMGLRCTHLVSTKRPDAMAFFGFRPRKTDSEDRPQDGTLKRKASDGDGEWEQWPGADLQLDDPDGLLEGSSSNQHTPDQSPGRRHGKEIAPNPTKENAEEEQWWDCPICSRPQTADERQFNEHIDLCLSRQTIREAVQADGPSIKHDPTPEMKKPRMTEKKRGRPKVPDPKQRQLFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLH7</accession>
    <name>S0DLH7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to tenascin X</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425367.1">
        <property type="nucleotide sequence ID" value="XM_023573693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLH7"/>
    <dbReference type="STRING" id="1279085.S0DLH7"/>
    <dbReference type="GeneID" id="35393566"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00081"/>
    <dbReference type="HOGENOM" id="CLU_017590_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157:SF4">
        <property type="entry name" value="EB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157">
        <property type="entry name" value="PRION-LIKE-(Q/N-RICH) DOMAIN-BEARING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484682" evidence="1">
        <location>
            <begin position="21"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="678" mass="70059" checksum="DAD79AA669F0F7FE" modified="2013-09-18" version="1">MTKLNFPAILLAIFVTASYAQEVPSQQPLPDPVENLPQSHTIKRSCNAACVQVSLDDITPSLDSKGHVKCCPVGTTFDGTTCVSKPTTVCPPNTTLQAGACVSDQKPSCPAGTVLQDEKCVSIIEPGCLSGARFDSGNCISIQPPSCGPGFDFNGVSCISTQPLVCPAGYTVVGSLSMTLEDGLCVKKQTPVCAAGFVFNEDSKSCSHLEKPTCPSGSTFSGRVCISDKLPKCKEGEYKGGVCQSSEGPECVPGATAIDSTCAMPFFCQDGLVKSRDPKTGGENCCPEGMGWNEAKRLCLRPATDSTACPNGSSFNAGECASTPQDIDCPPGFTFNGRVCAHFQAPSCSENTSLSNNTCIFTDKPTCDEGTFNGSACVTSQTPSCSGESILSGESCVSTIPTSCPDQMILRGAWCISASNPVCPPGSTSAGGICITTSTPTCVTGTLKDGTCIASTGPTCPDQTVFDGKYCVSRDPPACEAVFTWNGTACVSHVIPACPDNATFDGTACLHKQAPTCPSNTHLQGDKCISQSRPNCPENYVFSSQGCISGKLPECPPDMHLQGENCVSSEPPTCLPGTQLINGSCVAINGPNCPPGSQLRPEGCVTITVPSCPHGSSLRDNKCVSSGGAKCTLPLVVSGDKCVSPEPPVCPAGTTLSLGKCTLVATHGCYSMQYCPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLI0</accession>
    <name>S0DLI0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425371.1">
        <property type="nucleotide sequence ID" value="XM_023573698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLI0"/>
    <dbReference type="STRING" id="1279085.S0DLI0"/>
    <dbReference type="GeneID" id="35393562"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00077"/>
    <dbReference type="HOGENOM" id="CLU_062257_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="264" mass="30349" checksum="42E5DF11FAD9497B" modified="2013-09-18" version="1">MDKSTKRPDKIPSPIRSLQDLTIIEAWDTETNKPKYVTFYHVTPEEEVFFAQSTKNKMELSLAEFTAALHHVRDEEIYPEVPKDANLKLAPDHIDGSLVYIKRPGLNNYETMKGTDFIPKELLAETLTMEKVSQTPHPHIVGYYGCRVRRGRITSIVLEKLDQTLQQYSSTPEFKKLDKLKFLEALESAVHHIHSLGLAHNDINPHNIMVKDGIPVLIDFGSCQPVGQRLQSLGTEGWYEELFFTSETKHDTYSLNKLRDWIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLL0</accession>
    <name>S0DLL0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to nicotinamide mononucleotide permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425407.1">
        <property type="nucleotide sequence ID" value="XM_023573738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLL0"/>
    <dbReference type="GeneID" id="35393525"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00040"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT63326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="499" mass="54938" checksum="A0AA83FAFACC745E" modified="2013-09-18" version="1">MATVPVDESLKRSPSSHAEGTSTAYQRMPESLLHLNEEEIALMNKKLVRKIDSIILPIIGILYILNYIDRQNLAAAKLHGITEDLNMTTEEFATAISILFVGYLPFQIPSNLIIARIPRPGMYICVAVVIWGTISACTALVKSYGQLLAVRAILGVAEAVFFPGAIYYLSAWYTKTELGKRIASLYIAQQVGNAFGGLFAAAIFQLDGRHGIKGWQWLFIIEGSATVGIGVVCAFFMPEFPYNSRILSQPERDLAVWRIESTTGAAEGSEKESTLKSFGKALSDPKLLLLILCNLLSQAQGSIANYFPTLVASLNFGSTVSLLLTAPPYVLAGAVYWVLMWYSDRKNTAYPIIIGCIAIAIGMYIIPMSTLNMPARYFSMMILPFASVGPQLVLYKTINLHLARPVSKRAAASALVNAIGGTSNIWASYLYYAPPHFYAAFGTLMGCAFLFAGTITFYRWLVLRENKRLDSGDPEEIAKVVKGGVTEEMVQLGWRYEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMC1</accession>
    <name>S0DMC1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ChrR-like cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425855.1">
        <property type="nucleotide sequence ID" value="XM_023571570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMC1"/>
    <dbReference type="GeneID" id="35398549"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05068"/>
    <dbReference type="HOGENOM" id="CLU_146491_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="1">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="122" mass="13990" checksum="6C83EA8B03B5AAF9" modified="2013-09-18" version="1">MEQFEFHPATTSFNRAWSTIESGVDELVLNEDSQTGRRTTLQRWQPGARNQQDIFIHDYVEEIFMVEGDLYDQNLQQGWKKGAYAYRKPGMRHGPFKSEGGCLMFIVCIPVDANGKEAGDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMJ7</accession>
    <name>S0DMJ7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide exchange factor synembryn</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423869.1">
        <property type="nucleotide sequence ID" value="XM_023575550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMJ7"/>
    <dbReference type="GeneID" id="35395207"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01722"/>
    <dbReference type="HOGENOM" id="CLU_015532_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="53032" checksum="3ACA06E206FCB8ED" modified="2013-09-18" version="1">MAAQQPFGIPTGAKKLEKVTELVEALTADLEEDQFLPDGRATALDQLKLYSRDPRNAEPLYSEAVSTPPGFSMLLRHAYDKPSTKSARAALKVIANLMLLVPPTRHMFVDKGFAPKAIKELDTGNYEDEFLNSRILFLTTYETKIDLKELLDNEKLADRIINNLAKHAKEMDTKAKADPMQDMALTETVKLLFNVTHWCKEKASLFNPAVPHLIAVLFKAEVSQTKPLDPPVGFIINGFLNLDLSTPESQNALHPKSDPERVVSRVIDLLDVSIRTIPDEQKDPSVVPVLGLVRSIYEHAPDSTKFFIREKLLPTEEERKDVLGKGHSLPAKLLQNSNNPMAPSLRNLIQHVLFELSDKDASKFVKNVGYGFASGFLFQNNIPIPASVAEAHGAGDAAKAQKPVNPVTGQFVDAEKPVDEPEMTEEEKEREAERLFVLFERLKKTGIIDVQNPVEAAVREGRFRELKDDEVEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNM4</accession>
    <name>S0DNM4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_04620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426265.1">
        <property type="nucleotide sequence ID" value="XM_023572072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DNM4"/>
    <dbReference type="GeneID" id="35398101"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04620"/>
    <dbReference type="HOGENOM" id="CLU_001858_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="936"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT64184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1294" mass="145149" checksum="AA12BE66C15509D5" modified="2013-09-18" version="1">MTPDAVRPRDNSIELTADLDLLAGLWQEAPFARLPPDAPPDLMAYVQNVENPARVYAIHQASRRHGFQLLVERYILQLRSGCENVNCATPTCFTCRRRLAGRAPIRRYNTTSARTLAIYLASQDDPEKGLCPFLRKSREPAAAFGNLIFSTRSSSSSHPDHNRASAATLPSARKERISRPRALSLSSQDVPACPTDDPSDPISPIRHASKPAAACTPHLSDRDCDLVSQIRVIEAPMSKDHRSFAANLFGTVTFKMLEWLTPRSVAAMATKISNLDSAGDFDLPQGPASLARTTAGSDIQSTAPEESDTTASTTVAVQPHATDMNETSFIPKPPKPSNGSLSKSRKNSASKHRRRSTDSNNTTKSGDKVKSTKASQVNSTLHEKSVRPRHNKSLSGRGIPEVSLKPGFFENVTKPSAQSLSPASPSTLAHAEPFGESRSKDDANCGHLRINNSQRTKNLDIALPDISSHSLENILPQALSQLDVNLVDFICDIYEEDGTAQSVIASASDATHPYPRPVNQRKPLRRQSMSRTTRSRKQWQRFNDQTLFNVLMDPQVIVQSFTHDRKLYDSQTLWYCFHRLSRVACNLVFHSLWLAAGRLFVPPQDSRSHNSIKDNDSRLQKHKGSLSDVDAGYLMSICMHALVAAAPAVQDSRTLYEMSRVRSNGLTLAGRSAMARQSSSRCLDYDDAFSNDLAIRLARRLFCAITARRHFSDKMDNAGPLNETENNKVDILQPLVDQLDFLSTGSAAILEFPQSERLLHETRVPTVLLDWARTILLNEWDGRADFTMDGPFGGALSFIETLHANRNLLLLGDIQFRVDYLSERLDSIEMPVDWLAFNSTRWRRHILDYPYIFSPDTLVSFFRSINFARMSRMFEESSSLKTRMSAIVDPGSLITNPHHKMVLQDLLRTASSKYLVLEIGRSNVARDAFDQLWRREKRELLHPLKVHLGENSGEEGFDSGGVQQEFFRLAIAECLDPQYGAFTVDERTRMAWFTPGSLTEDWKYELVGLLMSLALYNGLTLPITFPRALYRKLLGKPVEELHHIADGWPDLASGLTTLLEWDEKDGLVEDIFARTYEFSVESLGTVVTRDMRMDEQADWPKAASSSCDIAPPHMDNPDDAPLVTNENRDDYIIDYIRHLTDVSIRRQYLAFEQGFNSCLDRKSLSLLSPSTLQSLVEGVQEIDISELKRYARYVGWDASHRTIKDFWSIVKRYDERMKQRLLEFVTSSDRVPVGGMKNLQFVIQKNGEEDGAGGHLPTAYTCYGTLLLPEYKDKEVLRERLGMALENAQGFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNT5</accession>
    <name>S0DNT5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to F1F0 ATPase complex assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424344.1">
        <property type="nucleotide sequence ID" value="XM_023581383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNT5"/>
    <dbReference type="STRING" id="1279085.S0DNT5"/>
    <dbReference type="GeneID" id="35394685"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01200"/>
    <dbReference type="HOGENOM" id="CLU_1082001_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="257" mass="29423" checksum="CBA6B47C9BC9B3B9" modified="2013-09-18" version="1">MLLSQLRLLEVTESDKKDTSYRNPFLVRSECPYRLKLERTLELIIDRYDSDGKSFIAPPRLFKAELSLFFPNFYGETLLKTDKNPRDTTPLLTGKATVVSFFSSRWAEQQAATFTSKEENPGLHEVLNKHPGTTQIVNINYEDNAGKAWLVRFFLGSLRKQFPEKDWDKYFLVRRGVTDDIRESIGLLNSKVGYVFLVDQYCRVRWAGSGTAHPVEAEGLAKGLSRIVDEMRNEATLPATAKEQHPGKHHLEVPKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP61</accession>
    <name>S0DP61_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_00196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425263.1">
        <property type="nucleotide sequence ID" value="XM_023573564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP61"/>
    <dbReference type="STRING" id="1279085.S0DP61"/>
    <dbReference type="GeneID" id="35393681"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00196"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF3">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE ALDH (AFU_ORTHOLOGUE AFUA_8G02310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="501" mass="54207" checksum="32C4AE2BE93AFC4F" modified="2013-09-18" version="1">MAASIELTAPNGVKWSQPTGLFINNEFVPSSSNKTLTSIDPATEQEIATVQSADSQDIDNAVKAAKAALRHESWRDLPASDRGQLMARLADLIESKRELFATIDAWDNGKTYIETLENDLVEAVGVIRYYSGWADKTFGQTINTTPKKFAYTIRQPIGVVAQIIPWNYPLSMATWKLGPALACGNTVVIKAAEQTPLSLLVLGELIKEAGFPPGVVNIVNGLGKDTGAALVQHPLVDKIAFTGSTATAASIMGVAAKTLKNITLETGGKSPLIVFDDAELDQAVKWSHFGIMSNQGQICTATSRILVQETIYEKFIKEFIDTLNTVSKVGNQWDKETYQGPQVSKVQYERILEYIDIGKKEGATVAAGGHPLKVGDSDKGFYISPTVFTDVKPSMRVFREEIFGPVVVISTFKTEEEAVELANDTTYGLGAAAFTTNLEKAHRVAAAIEAGMVWINSSQDCDPRVPFGGVKQSGIGRELGEAGLEAYTQIKSVHVNMGNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPQ3</accession>
    <name>S0DPQ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to UGA4-GABA permease-also involved in delta-aminolevulinate transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_00914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424609.1">
        <property type="nucleotide sequence ID" value="XM_023569763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPQ3"/>
    <dbReference type="STRING" id="1279085.S0DPQ3"/>
    <dbReference type="GeneID" id="35394399"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00914"/>
    <dbReference type="HOGENOM" id="CLU_004495_6_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="513" mass="56455" checksum="3FEF3100AFAF2B30" modified="2013-09-18" version="1">MASILDRDPDADKKMGPRNSIASDFAEDEVVHDFGYSPSYARVFRSLGTMSLTKAMASPMCGIFIAVSYQINYGGYWGLTWGWFIPSFLFLPWALTTAEFCSSMPVNGANYWWTAALAPPSIFRPLSFIAGMANIMNALTSIASFAWASPSSICTIIGLFTGWVPTNPIIFAVAIATCAAWFFTASIRMDKASLVFISSATLVLVSLACFVIGLPVAQETQSMPFTSAATVFGDYTNYIAPRSIINTYCLQAGMGMIFCTLLAFCITDMEAAASDPTGYAAFALLIERWGLKVAGAFLLIIFLSTSIGWGYALNYKLSYVSPRSNMPIYTTMFLTIGGMLMLCLGFSPIASETIYSLAIIAVMVLYALPMIFRVFDNGRWVLGPWNMGRFSKPVHVLGFLTVVYMMIMECFPPQATWTGAMLNYNWAVFLGAVVLSTLLWFSHGSPHYKGVNQEMLRAWREREHDRGLSQEGSGESRSETYIEGVKPQPFSSPKMSSSFFCQCTLLPNPLIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQB6</accession>
    <name>S0DQB6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to G1/S-specific cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424839.1">
        <property type="nucleotide sequence ID" value="XM_023572607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQB6"/>
    <dbReference type="STRING" id="1279085.S0DQB6"/>
    <dbReference type="GeneID" id="35394143"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00658"/>
    <dbReference type="HOGENOM" id="CLU_020695_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="88"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="183"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="186"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="397" mass="44844" checksum="04B639844D92C424" modified="2013-09-18" version="1">MAYSQHDDSYFVESEEPHHRITAQEAARMMARQRQDIIGVELSRLAGDEYLEDIMQHMRQMEDETLPDASLIDMQREIQWFMRPYLIDFLIEAHAAFGLLPETLFLTVNLLDRYCSKRVVYKQHYQLVGCAALLIAAKYGDKKDRVPQIHELNNMCCGLYDAGMFTQMEMHVLNTLDWIIGHPTVDFFSQLMVAEEGDDQEVAHMAAYLCEIALYHRDFVSTKPSVMARSSLALARAILGRSEVNDGGWDQTENVTLITLSHHLHQPSPTLARKYSTTGFSRVSQKLADFMAEQAAIARRAANPATPLAEPINKHTSNIYSTPQKGHSAMGFDGYLTPPITPDGNSLMGNHNMAKESYGLPPRCPVTPTPPHHAAVYGQQQQHHQYVGYVNQHGMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR40</accession>
    <name>S0DR40_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metal-nicotianamine transporter YSL11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427001.1">
        <property type="nucleotide sequence ID" value="XM_023572969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR40"/>
    <dbReference type="STRING" id="1279085.S0DR40"/>
    <dbReference type="GeneID" id="35397297"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03816"/>
    <dbReference type="HOGENOM" id="CLU_010539_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="672"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="81084" checksum="644A1B5E0C760E9E" modified="2013-09-18" version="1">MVAETVVPDRVPEDTLQPRYDETAPHRYDEKEPHFDTDLKSEADSEDDRIVDLFSSFPPAKGVEHEPNPLTARAVIVGIILGSLVNASNVYLGLKTGFTFPATMFGAIFGYGFILMLTKSLPHVPILGGKFGPQENSIIQAAATGAGGMSGVFVAGLPAMYRLDLLSDDPKKDFGRILTITFVCAFFGLFAAVPLRRFFIINVARELNLVFPTPTATAMTIRSMHAVGSGAADALRKIKALGIAFIIALLIICVGQYADGILHNWHIFTWFYVWSGYTASGLLEPENWGWYIQLTPAFFGSGILVGLNAAVSWWGGTVVAWGLIGPLLVHYGECIGIAVGEGKWEGITRFSVMTGVDDPDYVPSPRYWMLWPGVMVLMVYSLIEFFLHGKVVWDGIKFAVHESARSINNRLQARGHSNAWFAKQAAKADADGGVEDFASAQDQVPTWVWVAGTLAALVLAMIVSEVQFHMNAGLALLACILGVIFAFMSIYGGAVTDCAPLTASAKASQLVYGGITKNHFAIKDAQRINLVAGNIASGTADVANSLVSDFRVGFLLKTPPKLQFYAQAMGTVVSVFLAPGIFVLFMSAYPCVYRPSDDPADICPFAAPSVAAWQAVATAVTMPSIPIPKSSAYFSIAMGILCAVQAIVKHFWLVGSREKYRDWLPNWMSVGVAWVLGPDSGYANAILFGSITAWWWRKWFNNHFEMYAFAIAAGLIAGEGFGGVINAALELGKVSGSFKGTEIALPGAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRV3</accession>
    <name>S0DRV3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to lambda-crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_02238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427385.1">
        <property type="nucleotide sequence ID" value="XM_023573945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRV3"/>
    <dbReference type="STRING" id="1279085.S0DRV3"/>
    <dbReference type="GeneID" id="35395720"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02238"/>
    <dbReference type="HOGENOM" id="CLU_009834_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="322" mass="35253" checksum="D9F6A2B657BC5F39" modified="2013-09-18" version="1">MTQDIRTVAIVGCGVIGMGWATLFLSRGLKVIISDPAENAENILKRYFEQSKSYLEGFGDYDELVSNYEFVHDITPRLAEADFIQENGPERLELKRGLIATLDKHARPGVVIASSSSGLPSSEFIQRCTQDSTRVLIGHPFNPPHLIPLVEVVPHPGTSSESVNITLNFYRSVGKRPILLHHEVPGFVSNRLQAAINNEAYSLISRGIVSAGDLDAAVTSGPGLRWALTGPIATNALGGGGGPEGFSQRMERLGPAIRGWEDDILKHRFDWSEQRLLALQESVDQSLGAVNWDKLVEQRDLVLLQLLAAKEKMVSISTPLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS32</accession>
    <name>S0DS32_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_00956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425454.1">
        <property type="nucleotide sequence ID" value="XM_023569296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS32"/>
    <dbReference type="STRING" id="1279085.S0DS32"/>
    <dbReference type="GeneID" id="35394441"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00956"/>
    <dbReference type="HOGENOM" id="CLU_074845_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT63373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="194" mass="21786" checksum="C4F20F6F63C1B104" modified="2013-09-18" version="1">MDATQPQPAPGSLSWRLSAHPITLLTFLGFRISSVLIYFLGLWIIKSMIMIFIITILLLAADFYYIKNIAGRRLVGLRWWNEVDPQTGESQWVFESSEPGTKTVNPTDSRFFWLALYIQPMLWVLMAILALVRLQFLWLPLVVIALVLTIMNTLAFSRCDKFSNASSIAGSAFGTGNLAGSLASNMVSNWFSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSL8</accession>
    <name>S0DSL8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427625.1">
        <property type="nucleotide sequence ID" value="XM_023574233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSL8"/>
    <dbReference type="STRING" id="1279085.S0DSL8"/>
    <dbReference type="GeneID" id="35395977"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02495"/>
    <dbReference type="HOGENOM" id="CLU_045421_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484489" evidence="2">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="333" mass="38209" checksum="5667412FE582889F" modified="2013-09-18" version="1">MRLSLPFIALCAAPAVIGFVIPLGINHKDHDHHDPDLVKHHHKHHDHKHKHLHPHEHIHVTKHKHPEKPCPILTEEKTCKLFHYATKDVEELIHAAQTYDCGNEAECWHKIVHKIYSLEYGLDAFDKYVDSTTLKRCLTCGNDSPVVGCFLHYADALIRLLKLLRHQTKTLDGEVERPVLTAINSLRVSNYALVYEIGRRIECKKSLKIIMSKQGANDGTTKGSVQAAFAKFPYTPLITGEKFENGVALDKTDGKGDSEGDGENKHKKVHKHYHNHHHGHKHGHKHGHGHGHLHEHGHLHGHKHGHKHENEHHDEHKHEDKDPEHEHEYDHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTQ5</accession>
    <name>S0DTQ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to zinc finger protein odd-paired-like (Opl)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426853.1">
        <property type="nucleotide sequence ID" value="XM_023572794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTQ5"/>
    <dbReference type="STRING" id="1279085.S0DTQ5"/>
    <dbReference type="GeneID" id="35397455"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03974"/>
    <dbReference type="HOGENOM" id="CLU_064755_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF65">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="321" mass="36351" checksum="9D71F41C72C03AB4" modified="2013-09-18" version="1">MEGQCFVPLDTGFTFASSPDAPLTPTSSPRSEWMESGPLDFNHLYNNAYLWINTTFSSPSFMSDTMRPEARDLSYQHVHQQNISMDYQHMQHTNTVDIAPVSPISPFAIPNAPGTCDSYSDVSTMPSPQALSRLGSISSMSSWSCSVDSPSSDHSETRHSDVSNCLGPDPYASPLHTSRSICEMRSPPVMRNLSKENSVSLQRRVPKPRDQPFRATLPAGTKIIKKATGECDYPGCNKAFRRIEHLKRHKQAKHGEGENNFSCEFCGKDNFNRWDNLQTHRRLHTRNNKRYRSIKFVPAAVAIIEEEDLTRKRRVTLRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTY7</accession>
    <name>S0DTY7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_04815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426089.1">
        <property type="nucleotide sequence ID" value="XM_023571853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTY7"/>
    <dbReference type="STRING" id="1279085.S0DTY7"/>
    <dbReference type="GeneID" id="35398296"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04815"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000050">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT64008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="113" mass="12056" checksum="F4F9AF7E43C3A0C4" modified="2013-09-18" version="1">MGVQKTIISEGSGPSPKVGEKVTIQYTGWVKDESKPDNKGDQFDSSVGRGAFVVTIGVGQVIKGWDEGVTQMQLGEKALLDITPDYGYGARGFPGAIPPNATLLFEVELQKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUA9</accession>
    <name>S0DUA9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428255.1">
        <property type="nucleotide sequence ID" value="XM_023574994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUA9"/>
    <dbReference type="STRING" id="1279085.S0DUA9"/>
    <dbReference type="GeneID" id="35396659"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03177"/>
    <dbReference type="HOGENOM" id="CLU_021599_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="480" mass="55037" checksum="292148C03F8CD071" modified="2013-09-18" version="1">MVGVPGKYKGCETCRRRRVKCSNERPYCQKCISSGRQCEGYERERVFITGTPQNKGRVASHPKKGSSSKKGSSPLYEEPPRTLGITPVHPLTSAWDDHTLVSNQGVEYSVLVSALHTRLPCTLPDHSADDSTPFRITFPPYTPTDFQSLLGEGEFGVRAQCLARLPSVYEQDDSAQSYCIFFFEHETAYAFGESESQRMRRMGPAYFSLFPNHHFFVRVYRPLATGFALLRRQDTFVSSPDWKTVPWQRHPKSLLDHLLDLVLLLPAILSQVDQIVPAEPTLHRRHSAQQLLRDCLSLERHLDAWFQMANRPSFEQPVAYWTEELISPGGLIPFTNSYAFRDANTGLAFLYYWMTQILFHQCIESLHRAIYQPVIDAYPNMWPDLPFDLQIDLNRYQHGRMFAADICRGLDSVLHDTVQPDMLIMPMTVAMDLYRDINSVSQDGLMEIMWIDNFRSRLIEKGQHVAGVLQSQTWSEVATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUQ6</accession>
    <name>S0DUQ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428251.1">
        <property type="nucleotide sequence ID" value="XM_023574990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUQ6"/>
    <dbReference type="GeneID" id="35396655"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03173"/>
    <dbReference type="HOGENOM" id="CLU_047846_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="406" mass="46417" checksum="CA3821A67EF82D86" modified="2013-09-18" version="1">MLNRSLILGLRPVAGPRTSLALPAIQYRRFSISSARSFSAVFAETKNPQLNEILIEIQEKIILPAHLPEKARKLVFDPKKSDYIQRNPVTIEVDGLEHTFKTIDRFNGVPNSMKAFAEATKLMKTKEEWDNISTLLAGYKKAGIKLKRWHADAVTRRAGHNRQPYVVIECAQQVEKTGLSLQRDSTVILLLGSINRKIISPKGEESETQQALKWNKMVWDIIQRSEHLAKNTPPRRQPHMNPVIRGMILFSQASAVKEQQAAGAPVDDLIRELRDNIEFITSAWAERESDDLTSSPYLNSINSRVKPNSDNYVRERQHLSPFNYIWTLAQNIRAIELAQEITGEDAKDLQPVHDLMEKHIEDFVMMSPDNNSFGWDMAYERATGRQPSWKQHLPDAPRPRNDIEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVF8</accession>
    <name>S0DVF8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428541.1">
        <property type="nucleotide sequence ID" value="XM_023575346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVF8"/>
    <dbReference type="STRING" id="1279085.S0DVF8"/>
    <dbReference type="GeneID" id="35396974"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03492"/>
    <dbReference type="HOGENOM" id="CLU_090929_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="159" mass="18398" checksum="7285045BF29395F3" modified="2013-09-18" version="1">MTTLYQQSVPVLVKYLKNLSFMLQKGAKFCDEKEMKHEDLLTYLQSCSNTAKFLASRLGAQNIPTFEDDEQTFEQLQARITRTIEVLEGVDPEVINGKENEEIIMESKMGNFRFTGQRYVSEYVIPNFHFHLTSAYCIMRTQGVPLGAFDYLKDVFEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DW45</accession>
    <name>S0DW45_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427683.1">
        <property type="nucleotide sequence ID" value="XM_023574303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DW45"/>
    <dbReference type="STRING" id="1279085.S0DW45"/>
    <dbReference type="GeneID" id="35396040"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02558"/>
    <dbReference type="HOGENOM" id="CLU_062889_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="254" mass="27656" checksum="2FEFBB788CDEF2D4" modified="2013-09-18" version="1">MPPRIPTQDDFSPLSSTLPHTLHFPSPPESTTTFLILFHGLGDHDVPFASFAKNLNLPGVLAISVRGTSVLPAALLGGDRPGYHWGDDLTVDPSTGDIADDSGFEKARNLIMEKLIGELLIEKCGWEMRDIIFFGFGQGGSLALGLAASLNKTPRVTDVSEGESTSPGNKKFKGAVSLGGPLPQSMVSTVTNRNKSSTSVLVCQLDEDAVDAVKREFDDVTVVQWKRREVSMPMNRDEVLPLMQFFADKLKNEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWF1</accession>
    <name>S0DWF1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428965.1">
        <property type="nucleotide sequence ID" value="XM_023575692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWF1"/>
    <dbReference type="GeneID" id="35406508"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13052"/>
    <dbReference type="HOGENOM" id="CLU_806634_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="383" mass="44450" checksum="C5DD45D082B5B438" modified="2013-09-18" version="1">MDLQLDAELRSVLKLKRLEDFPNSKQFKAIKQQLDKNSKCLKDLKTKSKKKTPKRKMKFPGTKIPASQLEKYKHPQKPVIPARKGLARKSTKVKPLDINRRSKRFERTKRQLEKENVSALYEISKLRHELRKEKRALAKERSERARQTLEIDLLRNDNISAHKNLSESQVALKEAQDRCRELEASLRSQKETTYTAQDLYTGESPITVHERSSDDVSDEFTMPYPIEEGSKSNKYEQNIVTPPPSQKRRSSVRTVATPPETPVAGPSNNTMLLAGHLPVVEDESFDLETEEIMIGHLKSDRVFRRFKEFLKKSHENLWYCVEEIAQFGYSFGSWNDSICENGEHDGVRCRQVKVTVVNSERQLCFKRDERESASSWQDGWGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXE3</accession>
    <name>S0DXE3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_13312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429206.1">
        <property type="nucleotide sequence ID" value="XM_023575983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXE3"/>
    <dbReference type="STRING" id="1279085.S0DXE3"/>
    <dbReference type="GeneID" id="35406766"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13312"/>
    <dbReference type="HOGENOM" id="CLU_006601_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="191"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="485"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT67125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="585" mass="65334" checksum="709182CD644126D4" modified="2013-09-18" version="1">MASLAGSLQAALPKPKYTGEDEEPPARAQQRGVRIVGPGQLDETQLVLKRSGPPAYGQRSGWRPRSQEDFGDGGAFPEIPIAQYPLEMGKKGGNSSNALAIQVDSEGKVKYDAIARQGHSESRIVHTSFKELIPLRQRADAGEIDLSRPDKESVEATTERTKNALAALVSGAVAAQKPKNVNIGQRKDATFVRYTPANQMGDNSKKQDRIMKIVERQRDPMEPPKFKHKKIPRGPPSPPPPVMHSPPRKLTAEDQEMWRIPPPISNWKNPKGFTVPLDKRLAADGRGLQDVVISDSHAQLAEGLKTAERFARDEVQKRAMMQQRLAEKEKSQKEDTLRELAQKARAERAGAGRGRRDSRDSGDSRDSRSRSRSYSYSDSDRSDSEDEEVRERVKARQEKQREEERKLRQNRMGAERRAQVMAREQGRDISEKIALGLAKPTQSKETMYDSRLFNQTSGFDSGINEDNPYDKPLFAAQDAINSIYRPRANVDDDDDGEAGDREMAKIQKSSRFGEALGKGTFKGAADAEAREGPVQFEKDAGDPFNVDKFLSEVDQNSSSKRGYGLQDEDNRQSKRPRVDPDDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYU6</accession>
    <name>S0DYU6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to acetyl-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_14782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429845.1">
        <property type="nucleotide sequence ID" value="XM_023576765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYU6"/>
    <dbReference type="STRING" id="1279085.S0DYU6"/>
    <dbReference type="GeneID" id="35408161"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14782"/>
    <dbReference type="HOGENOM" id="CLU_019364_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="130"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT67764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="382" mass="42705" checksum="3676E33BF6FAAF8F" modified="2013-09-18" version="1">MAVLSTLKTAFGYTYAFIITPWLLSRFLFDISLCLVPWFRPNRKWTLNQAVRVRVVRLLLLYWSLTKSGDKMRFDQGKEKNRFEVVAPRSPKLYRGICSDYTVQPAQLGMTWTPARPPPASIVHPGMVVVLHFHGGGFVIGNGRDEDTGFTAKTLIKHMGATHVCSPNYRLSSSKNGQFPAPLQDALTAYLHLIKTRGIPADQIIFSGDSAGANLALALVRYIHEYGQIDEVPFPRAMALWSPWTDVAGALEQDATQSPNYKTDYLNMHFARWGATTVSGFGAIDPASPYLSPLRHPFQIEKPFPVYVNAGGGEVLCDDITNFVARYKKNGWPMYLDISEGCPHDIILLGDRIDFAAEAEKAAEHARRFLNHRAGLNLRSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYX7</accession>
    <name>S0DYX7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to CSR1-phosphatidylinositol transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429842.1">
        <property type="nucleotide sequence ID" value="XM_023576758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYX7"/>
    <dbReference type="STRING" id="1279085.S0DYX7"/>
    <dbReference type="GeneID" id="35408155"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14775"/>
    <dbReference type="HOGENOM" id="CLU_016665_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901352">
        <property type="term" value="P:negative regulation of phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001247">
        <property type="term" value="P:positive regulation of phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="128"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="386" mass="44726" checksum="D6D2149AA7160BCB" modified="2013-09-18" version="1">MPSSSEPGTRGNLTLEQKKSLQEAWVHILRLCGNENITHDAPDNTDEYLQHLKNKDSDHFSRNLWESIMADHPDTTLLRFLRARDWDVNKAVDMAVSALNWRDERQIQKTIVGGGEAVGLKKTLTTDEESFMAQYRSGKSYVRGTDKDNYPVYVIRVRLHDPHKQSAESMEEYVLHNIETLRVMAREPQDKVCLIFDLTGFGLRNMDFHVVKFLVDILEKRYPETLSVVLVHNAPFVFWGVWTVIKHWLDPVVASKVHFTSGTKGLLKFIAKENLQKSYGGEDPWEYKYIEPVPSENERMQSEEKKIKIQIERQELIDSFNRSTVDWIGTDPDTDAGKEAHERRDEVIQLLQMNYWKLDPYVRSGTYYHRAGVVNRVGGVDFKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZR6</accession>
    <name>S0DZR6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_06835</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
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        <property type="protein sequence ID" value="CCT68074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_023577021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZR6"/>
    <dbReference type="STRING" id="1279085.S0DZR6"/>
    <dbReference type="GeneID" id="35400312"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06835"/>
    <dbReference type="HOGENOM" id="CLU_027174_0_1_1"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HgmA_C"/>
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        <property type="entry name" value="HgmA_N"/>
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        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF5">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="15">
        <location>
            <begin position="36"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="14">
        <location>
            <begin position="316"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT68074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="535" mass="59875" checksum="93356C54849A4A63" modified="2013-09-18" version="1">MVAAIKRREPATDPQKVFHYTDLQRTKPTRENDPYEYQAGWGNRHQSEVIPGTLPAGQNNPQDRGFGLYTEGITYSAFAAPRGLNMSTYMYRARPSAAHQGYSSIETKSHIENCFLSLNPKVEPLYQQAEWSPFPLPKDDETIDFTDGLHTLAGSGDPNLRQGIAVYVYMINASMINKAYCNTDGDFLITPQLGIIDIQTELGRLFVQPGEICVIQRGVRFRINLAEGVPVARGHIAEVWGSMWELPDLGPIGGHGLANPRDFLYPVAHIDEDLHVPFKIVVKNNGKHVVISQDHSPFDVVAWHGNAVPYKYDLTKFASQNSTSIDHTDPSINTVLTAKSFDPHVPLADYLWFGPRWDVASNSLRAPYYHRNSATEMLACIYGAGLGRSDDFLPGGCSYEGGHTPHGGFGEEYITEAILQHNEPRRILENQMTIMVESSRTFLFTEYAREICGVLHKQATDYRVWDNLPDRFSAHPLTKQLLERVAKDKVNQKKAVDYYHSVQLLDAKGQPTQVLPPLETNGHAKISAVDAAVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E011</accession>
    <name>S0E011_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCT67985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023576909.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="35400213"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06736"/>
    <dbReference type="HOGENOM" id="CLU_048587_1_1_1"/>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF2">
        <property type="entry name" value="DLTD N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G00380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="31"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="293" mass="32163" checksum="CE9186E8AEF1212B" modified="2013-09-18" version="1">MASIRDVDITTYDDLNLRGTFYSVGSKKPCIIMTHGFSGHRDHFLPELAAKFNDAGYGALVYDNRCWGDSEGLPRAEADPVKQSRDYLDAFNFAAALPDVDPTKIVYWGSSLSGGNAIVAASMNKSLAGIISQVPFVSGGSMARLTAAPKPILVAQRTSNSEIHIPIYPSSVEEVRDGTTKAILKDEGAVEFAAEMARRGYSYDKTATLQSLTNTIMHEPTGVIHHISPTPLLMVLADDDVCTYTHLQLEAFEKALHPKTLRIVKGSGHFDLYYGKRFQEVVDMQLEFLKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E049</accession>
    <name>S0E049_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428169.1">
        <property type="nucleotide sequence ID" value="XM_023574891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E049"/>
    <dbReference type="STRING" id="1279085.S0E049"/>
    <dbReference type="GeneID" id="35396567"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03085"/>
    <dbReference type="HOGENOM" id="CLU_013664_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="803"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="897"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="940"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120432" checksum="AED4FE65E51E4C47" modified="2013-09-18" version="1">MSSSVAVAAAPLQFHDYLQFPINDTKPPIPDFSKFRNLRGKSVYAESRKTFEVYADPPSEGAHFAEGDCYPRLDSDSPTLVARTVRRRSRSVTSLLTLSRERKLIEPVVVPALPSPSVSVSVGNRGVEFLKGLAGSVTGVIGSRSPRIAPASAANGNGPNRHRQDSLCSVPSIIRSPVPSALVSPCAQSFVGASGNLNLASAESQTAPSPAVPPGPSSPLASPLYVLTPKTTNILPFFSNLAPKPLTLRSPNLNQEFSRSTARLTGRDRSRSRSRSRSRSRSRSRSRSRPRGPDLFKPLPPTYAFDLPAPESPILRTVPSASDIARFKRRNLHALRINTETAERAANIEREDLEREEDEAERLAARLEAETDRILAEQKKRDLARRRAQLPTPSPKFPRFLVLDKFSFLYRTRRSNALTSQADTPSPGAPTAFSLDLSRPTSPEESSSPGKMSFIEQGGKGIVPGTDAPTSASNGGERRVCVRCISSVINLPVNTDTSPVDILYSTANLTSHDIDPKASVLIECYVELGLERRLRRYERIRDVMNSWDRDQQNSLLVVTNDISQSNDPDLDMKSVPRTPTPPPGFTLQMYHSSRPGKWNKRWITLLESGQMFASKKPDSKASDKDSTVLCHLSDFDIYTPRESEARRHLKAPRRFCYAVKSQQKTFVFPNGENFVHFFCAEDGKLARRFLELVQRWRSWYLVNKKVDFEKKDKPPQLAMHLENDTVPKAISRPKSSTTPKGHSTQVSVDETPYTIGAFQPLLDMDRFDKPLEEFGKDLEQDKTKHGDHDTEFKSGLVRKATCKQPNVLTSSKSIHQKRRSPPTPRDEAQFSSTGLLGQVYEEKRKIAERAPVVSLPPTNAAFTKGASLLGQGYEQKRKISERAPVNKSVASTNAAFTEGPSLLNGGVVSPTSPNENMADSKSWFPLGTDQSSQPRYRSRSVRDPNRRPTTSEKVPDMPQPLVNLTNSFPEPPRWRENKGHGVKAPAGGPLISLATGGPTNNSFNTRSASGLVGQSRPLPSSSSMTVVSRPRSRSIAGNQQSPSHAPPVPPLPIRSLRRENTAPLEQSRGRDPRPREPLINRAGTMGFSSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0A7</accession>
    <name>S0E0A7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428244.1">
        <property type="nucleotide sequence ID" value="XM_023574979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0A7"/>
    <dbReference type="STRING" id="1279085.S0E0A7"/>
    <dbReference type="GeneID" id="35396645"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03163"/>
    <dbReference type="HOGENOM" id="CLU_040682_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="45342" checksum="D2ADBF87EB040038" modified="2013-09-18" version="1">MPVIRSGSTRDIYKAPLSAVLRRHGRERRERWSQGEDPGDFMPPHQDEEPSHEPSEFSKGKQPEPQRLPSRAGYDTAVLLDLCDTIRSSLHEGRPEDRWEEAMGFLAALLRDEEHYNRAIEFETIRDTHLDKLISDLIDPKYRHPRVPIRFSKDVERAEALERKWVERFRGPYFNMEQNRYRDLPKTGRLRDVALNPNADNSEERWQAKEGKTLSELEGNLEIEPGHWWLNLACAHRDGIVGSAREKPTKGKYGVAALPLLTGQEKIDEGEGTLKYVRQGRITDIHVSLISQVGATFRILRGHHLRSPYAPKVGIRYDGLYTIRRYSQWFNEVSDRHHMMLTLERVEDQKPIEDIMHIPRPSEMDDWELYEKYEGEAIKKHKGNKALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0G3</accession>
    <name>S0E0G3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430205.1">
        <property type="nucleotide sequence ID" value="XM_023577080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0G3"/>
    <dbReference type="STRING" id="1279085.S0E0G3"/>
    <dbReference type="GeneID" id="35400366"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06889"/>
    <dbReference type="HOGENOM" id="CLU_792364_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495390" description="Protein kinase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="350" mass="38398" checksum="15AD626CC0FE3E30" modified="2013-09-18" version="1">MLFSSRFTFALGALLSFIANVSAASGEGSFPDFISNWALFRRWEDITGSIPVFDVPGMDDLIVGDWVNSEKKLTWECYTLTKDSLVANSLTVIIDKATLTWTDSENQPQQQTVVSKRSGIKSGDGNAIMYGARLQKALDHPNILPINHIVYGKGGVKDYGFAIMPYVQEGSVADNLGSLTDVNGAFKQMLAAVAAVSAAGIIHRDLKPENFLKDGDTIKLMDFDQSRDVGTTVQMDVGTPSYTAPEIIIGRDYTTKADTFSLAMSFLVMSVPDLRNSDDRFQLWKDLIEPPNTSYERVTADKTEEILRGRNYGVFNGNDGLLKVIAKAMCSESEGRYTPAEFETAFNGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E139</accession>
    <name>S0E139_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Surfeit locus protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428489.1">
        <property type="nucleotide sequence ID" value="XM_023575283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E139"/>
    <dbReference type="STRING" id="1279085.S0E139"/>
    <dbReference type="GeneID" id="35396918"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03436"/>
    <dbReference type="HOGENOM" id="CLU_109022_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.160">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17905" checksum="A780540965646010" modified="2013-09-18" version="1">MDTSTPTNLMDKHQKIISEILRSYRDLMNCVTVNGMDKEKQGDYEAQANKLNYRDPDTMAAAGLRTQRKFDELYESIKELLALTRTIKELWVFGPVDRADEHRKEKEEQIDRDIGEITTLFNKIDANAMRELAEKNGGTWEPQGEAALTSAAPAPTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1H7</accession>
    <name>S0E1H7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to PEX19 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430799.1">
        <property type="nucleotide sequence ID" value="XM_023577791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1H7"/>
    <dbReference type="STRING" id="1279085.S0E1H7"/>
    <dbReference type="GeneID" id="35401005"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07528"/>
    <dbReference type="HOGENOM" id="CLU_043063_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="445" mass="47540" checksum="87CEBF5812AB0EA3" modified="2013-09-18" version="1">MGMDKDTEVTLKEEATEGLKEAAKEGVKDEVTEDKKDEIEDTTDLKTEAEADADAASSSHTLMPDAPTAHTPASSLATPSLDSKPHNSASNEASAGDTAPDDAVPQDSSPKAAPQQPVSQEAATTTEAVAEKTDALPTPAPKAAITVDEMDEVPDPDEDDLDDLDDMLEEFSTVKLDQHKPLGAAAASSKPEAPKGAASGKQPEVEDAFSEDEFARQLQAGMADLLGELEQSPDMQAQFEDIFKHIAAAEGAGDAPPPSTSKGPSSQAPPEDASFQDTIKRTMERMQASGDQATAAAASGSADDFMSEMLKQLSSGDLGDLGGDGSEEEFSKMLMGMMEQLTNKEILYEPMKELDEKFPEWLIKNRDSTPKDDLKRYEEQQSIVREIVAKFEEKTYSDSNAADREFIVDKMQKMQAAGSPPSDLVGDMQSAQDALNPGDEACNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3A8</accession>
    <name>S0E3A8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430197.1">
        <property type="nucleotide sequence ID" value="XM_023577071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3A8"/>
    <dbReference type="STRING" id="1279085.S0E3A8"/>
    <dbReference type="GeneID" id="35400358"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06881"/>
    <dbReference type="HOGENOM" id="CLU_084538_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485257" evidence="1">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="300" mass="32795" checksum="78A93D76CF831BD5" modified="2013-09-18" version="1">MKFTSTSLALLASIPLVFSLPTEAQPPTLKLEKPQGFDKIQKADPEHWLQAVKEEAARQEAAAASTFNETEALEARASWIYQVHGMYTDNLVNVGDVDTFYMLWTRMYDSSDDKGGLSDITRGAWSKFCNGPGAGNGVTTRFILDGQWGAVGRLSGWSMRDALIHSMWQTADGIGKKNGYTVYNNCYGFTWQEAKPGRTNSACGGRSGKACPHNSDCPLEGMECTGLKWGTWMPSIIRMNVYNRDGSLRADAYQARISSQAPGSGGCSKAQTISAYVADFIPIVGPYFATGIRINCLYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E488</accession>
    <name>S0E488_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to BNR/Asp-box repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431606.1">
        <property type="nucleotide sequence ID" value="XM_023578626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E488"/>
    <dbReference type="STRING" id="1279085.S0E488"/>
    <dbReference type="GeneID" id="35398897"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05418"/>
    <dbReference type="HOGENOM" id="CLU_036301_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485279" evidence="1">
        <location>
            <begin position="24"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="379" mass="41305" checksum="7032E00EB7D266EC" modified="2013-09-18" version="1">MLGIKASLLLSCLALLNPASCRAIEERAVADHAVTFQTIYKPPSNYNTPKTLYGRNVQLADGTILATWENYSPEPPKVYFPIYQSKDKGSTWAPLSNVTDTKNGWGLRYQPFLYVLPQAIGNLAKGTILLAGNSIPTDLSKTKIDLYASTDSGKTWKYISNIATGGKAVPNNGETPVWEPFLMVYNNKLVCYYSDQRDPSYGQKLVHQTSSDGVTWDAVVNDVRGTAYSQRPGMTTVAKLPNGKWMMTFEYGGGASPNNAAFPVYYRISDSPLTFDSASNQILTAGSRAPSSSPYLTWSPSGGSSGSLIVTANSDNGIYINTNLGAAGSWVYYDIPQPGAYSRQAMVMDNPDWLYVMSAGYLNGDNWVTDSVFKLPNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E490</accession>
    <name>S0E490_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable Calcium_related spray protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_07284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430577.1">
        <property type="nucleotide sequence ID" value="XM_023577519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E490"/>
    <dbReference type="STRING" id="1279085.S0E490"/>
    <dbReference type="GeneID" id="35400761"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07284"/>
    <dbReference type="HOGENOM" id="CLU_010226_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495543" evidence="9">
        <location>
            <begin position="20"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="644"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT68497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="751" mass="81915" checksum="3BF8E5AA79BEEE36" modified="2013-09-18" version="1">MKPLAVLASVAALASPVSGEKILYSNSLNSCQKDNGFKATLFNVALTPNNGSAFVKAVATSSIQGKVIFDIRLSAYGYQFLQQTVDPCTINLAGLCPMVSGKIPFKFNLPVGKENLKQVPGIAYSVPDLDATVRVYVNMSSTGESVACVEADFSNGKTVDLKGVKWATAIIAGLGLISSAVVSGVGHANTAAHVASNSLSLFGYFQAQAILGLTSVGLPPIVSSWTQDFQWSMGIIRVGFMQDIFTWYQRATGGTPESILYNVRQVSVEVQKRSLQAASTSIDLFKRSAAMMPRSITEPIGHAAGALAKRANIQTEDGTYIVYGIQRVAFKSRIETTNLFMTGLTFFCIFVVITCLAIAAFKGVCELCVRQKWMAPDKFLEFRNGWMTVLKGILFRLTLIGFPQMVILCLWEFTQQDSPAEVVLAVFFLLGMTFTLAWGASKVIRIARRSVAMHRNPAYILFSDPQALNKWGFLYVQFRASAYYFIVPVLVYTVVKAMFVALAQKNDVAQAVGFIIIEVGFLIAASVLRPWMDKPTNSFNIAIAAINFINAIFLLIFSNVFGLPKIVVGVVGVVLFVLNAAFALILLLMLIVSTALVFFRKNPDARYQFMADDRASFMKSQTQVNATTELDALAATARGDKAGYSNKHLDLDEEDSVSSESLRRRAEMNNQSQTSFQRGDVPPRSPVNPAMPLFPADGQRPASPFRNASPNPYQQSTSNLSQQRSAGDSSPGGYRSQNNASPWQRGAGYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4H4</accession>
    <name>S0E4H4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431620.1">
        <property type="nucleotide sequence ID" value="XM_023578643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4H4"/>
    <dbReference type="STRING" id="1279085.S0E4H4"/>
    <dbReference type="GeneID" id="35398912"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05433"/>
    <dbReference type="HOGENOM" id="CLU_048587_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="329" mass="36101" checksum="436C3E676A9AEDDF" modified="2013-09-18" version="1">MGYHGRYTTEKVTYPSHGETIAGILYMPKDVANPPGVVVLGPYSFVKEQAPLQYATRLADEGYAALIFDPRTVGESTGQPRRLENPKMKNEDVVSGLDYLAGRGDVDAKRLFLVGVCQGGPECLDVASYDDRVVAVASVTGYYRDHETDVWMICTGCVNIEPGVDVGSLKMPTPEQGEALYQARIERAKKAKELYEETGQVIYQPLVDPKAADPDVGSLAGLPGPVAWTWYGPWTLKGFENRYAVMSDLDHFGYSTVPGVAKLTKPALVIHGDNCMNAPAAKRHFESIPAEKKKLIWDNGVSHFQHYDQPDVVDSNIGEIAAWFSQVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4L8</accession>
    <name>S0E4L8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to aspartic-type signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_05748</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431909.1">
        <property type="nucleotide sequence ID" value="XM_023578995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4L8"/>
    <dbReference type="STRING" id="1279085.S0E4L8"/>
    <dbReference type="MEROPS" id="A01.082"/>
    <dbReference type="GeneID" id="35399227"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05748"/>
    <dbReference type="HOGENOM" id="CLU_013253_9_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495552" evidence="9">
        <location>
            <begin position="19"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="66"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT69829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="516" mass="55143" checksum="9D5E3B0E51F6DA55" modified="2013-09-18" version="1">MRWTTITTAAALLGSVDAVNIPRSKAGKGYLSMHVGTVERNKDKQHDKRQDGDAIAVRLQNKDFFYATDIEIGTPPQKVTVLLDTGSNELWVNPDCEEAQSATQYNQCLDFGQYDPRKSKTPPIGPFGGETLNYGDASDSTTHTSATIRYYTDLMTFGDSKLRNQTFGVLVESNGISQGILGLAPDLRAGFDGDEPYSLLLTSMADQGLINSRVFALDLRHSDDTEGALIYGGIDRSKYIGKLETRPIIRGEGGEYRLAVELDSLGVTISGDTEDIRVSSSDSNVMLDSGTTLTRMHMSVARPILEALDAQNDGEGFYMTDCENRDLDGTVDFGFGDKIIKVAFSDFILELGPGTCYIGLVPTSDQQILGDSVLRAGYFVFDWDNKEVHLAQAADCGDEDIVAVGSGSDAVPSETGKCKSSDITATGRAATATGTGGSFPTSAYTTTYTITSCPDFERDCATGVVTTQTFSGRPTVTVTAGAGSGGDDDDNAAWQPTPLSWVFAVIGGFALGVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4T3</accession>
    <name>S0E4T3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA polymerase</fullName>
            <ecNumber evidence="22">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">FFUJ_05679</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 31">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="22"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431846.1">
        <property type="nucleotide sequence ID" value="XM_023578918.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E4T3"/>
    <dbReference type="GeneID" id="35399158"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05679"/>
    <dbReference type="HOGENOM" id="CLU_000203_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000024">
        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 22" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 22" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 22" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="14 22" id="KW-0408">Iron</keyword>
    <keyword evidence="15 22" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 22" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="28">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="27">
        <location>
            <begin position="61"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="25">
        <location>
            <begin position="842"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="24">
        <location>
            <begin position="1090"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="26">
        <location>
            <begin position="1577"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="561"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="799"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="CCT69766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1681" mass="191155" checksum="8FE5700DCD481D6E" modified="2013-09-18" version="1">MDLFRVRLNCIDHYQATPSRYDPQLRNDIRPSQISKGPRVPVVRVFGSTETGQKVCAHIHGAFPYLYVEYEGGLSPDEDHALAVSYRRDQKGDSARFVARITLVKGVPFYGFHVGYRFFLKIYMFNPIVMTRLADLLQQGVIMKNKFQPYEAHLQYLLQFMTDFNLYGCDYLDASVTRFRSPVPEYEQGSDSLHKWHSRSISANHITDETTLPRSSHCSIEVDICVQDIINRHKVKERPLHHDFTERTNPLPGDLKLVYSMAGLWRDETKRRKRKMQDPTEGSSPFPPEVLVSMSANTRDSQPQGWLHEEEFRTEIRNLITEEKLCADSEELTFEKFTKPHPYEEHVNTTLESVEDLFPSKLAPALGLPLGVEMEQDLRSSIVVDEGKVRQAGDAHNDFYPEDSDEEAIAALVAIEKAAAKVPRVPTELPEEDLELAAALNISPDKFDKKTFWRSALGICQSGLVTGELPDLPVSQQLLDYAENEGFIGRTEKAPTLTPSSLTQLKRPLDDLPSSQASNKRTRLNQLSMTDEDEMDLVPVPSTGANKILASSFRGASILKGPSSLNKNTGSVLKGVPGSSQKLNFPTVKDQNDPNTKLRLSQMSQKSASQQTDDGRHNKHVSFEPSSFLPAEAELSQMTLSSSMKSSGGQGDDESHESKIQRAMSRFTSPEVHLVSSLPPSAAAVASSLKEYGLPDVIYQDAYYSREKDVPGRMREYAGKEFRLESNTLPFLPEFDPTGTAPANYGLKFETFDKATAELRYERQRKKCSLRSWELANPPPTYQEVEEWWAEKQRRANSTEGSIIPCTPRQYQSQIDGPTPKNKHGFKYTPGKKSTSVQHEVQYMSTMSLEVHVNTRGKFVPNPEEDEVQCVFWAIKSDGTASGSQDSAGVQTGMLLLSNDADFTKRIQRQTNAEVIEENSELDLMVRMVEIVRNHDPDILTGYEVHGSSWGYLIERARLKYDYNLCDEFSRMKTESHGRFGKENDRWGFNTTSTIRVTGRHMVNVWRAMRGELNLLQYTMENVVWHLLHRRIPHYSWQSLTNWYKGGKHRELNRMLRYYQNRIKIDLEILDANELVSRTSEQARLLGVDFFSVFSRGSQFKVESIMFRIAKPENFLLVSPNRKQVGGQNALECLPLVMEPQSAFYNSPLLVLDFQSLYPSVMIAYNYCYSTFLGRVTDWRGMNKMGFTEYKRQKGLLALLEDYINIAPNGMMYAKTEIRKSLLAKMLTEILETRVMVKSGMKQDKDDKTLQQLLNNRQLALKLLANVTYGYTSASFSGRMPCSEIADSIVQTGRETLERAIAYIHSVEKWGAEVVYGDTDSLFIYLKGRTKDEAFDIGNEISKAITEMNPRPIKLKFEKVYHPCVLLAKKRYVGYKYESKSQVKPEFDAKGIETVRRDGTPAEQKIEEKALRLLFETADLTQVKDYFQKQCQKIMRNNVSVQDFCFAKEVRLGTYSDKGAPPAGALISTKRMLQDARAEPQYGERVPYVVITGAPGARLIDRCVAPEELLSNPHWQLDAEYYISKNLIPPLERIFNLVGANVRQWYDEMPKVQRIYHATTLGKKKTTLESYMKSTNCLVCGLKFSQEDNALCPSCRKNVPSSLLTLQTRLTTEERRLQEVLSLCRSCSGLGPIEDVQCDSKDCPVFWTRMRQASKMKGQRTASQPVIQSLVDSAEKLSLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4V3</accession>
    <name>S0E4V3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminodeoxychorismate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_07537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430807.1">
        <property type="nucleotide sequence ID" value="XM_023577801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4V3"/>
    <dbReference type="STRING" id="1279085.S0E4V3"/>
    <dbReference type="GeneID" id="35401014"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07537"/>
    <dbReference type="HOGENOM" id="CLU_020844_6_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30325" checksum="7ECE2CEBF65E793B" modified="2013-09-18" version="1">MSDDFSIFTSMRYDARLAQLKSRGCAGEGWNSENNSPLYMLDFHRDRLLKAATHWGWQSAADQISGDDGLSYLAQLIANAVGPSHPTPLKLKIVVSHQGDIRIEHSSTPEVPIHNLLPARLPNPFRPSLESEPRKVSAYTVLLDQASTTRSEYTHFKTTKRAMYDAARQRAGISYADPVEVLIVSQDDGSVMEGTFTTPYFWRAGRWVTPPVAAQFSWEEGNGGQDGTSRRWALERGLASEQVIDSKSLIHGEECWISNGVRGFIPATIRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E533</accession>
    <name>S0E533_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-dehydropantoate 2-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431880.1">
        <property type="nucleotide sequence ID" value="XM_023578959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E533"/>
    <dbReference type="STRING" id="1279085.S0E533"/>
    <dbReference type="GeneID" id="35399195"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05716"/>
    <dbReference type="HOGENOM" id="CLU_031468_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="146"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="305"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52362" checksum="9D094BCA758F6E3D" modified="2013-09-18" version="1">MQTRPTTQIARKSTRWLRGSPSFGYTRLFASAVPPTEQKKPEAVPPELGSTPSRPWKSSSTQAGSVTPTSTSPSSQFYVPSVVIPAEAAKSGPVHKIHILGEDVRSRFIAHALCSVYDSVETVPFREMPKSRYRNIEKVQPERTRKSAYVEKNAATPESDAVAQSDRSHIDELIVTGRGFEAVKAIASIKDRIDDKTSICLLNDGMGVLEQVREQLFNGTQPEPNFYLGHMSHALAFNRNRDSVKELRSGRTVFTKADPVLTAEKELYIPVEQQPSMMHSLRRVKELNTTFSNYEHWLRFKLPSVMFTAAVEPVCVLLDLSYQGLLENGNAQRMMNKLLGEMAIVTENMPEVQNSPDLIKFLRGEGLKKFCYRRITGKSKAPSDLLTRISKGLQTDINYQNGYFLKRARILGIDTPTNQLMVQMIKARRIEQNKKLRSFIPIQEASPNDVRKKFQHKFKNDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E555</accession>
    <name>S0E555_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432088.1">
        <property type="nucleotide sequence ID" value="XM_023579210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E555"/>
    <dbReference type="GeneID" id="35399420"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05942"/>
    <dbReference type="HOGENOM" id="CLU_809118_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="315" mass="36776" checksum="565DFC0F55EDC6F9" modified="2013-09-18" version="1">MSSSSHDLETISSLSPSTSVTTDFNSLPTELRLKIWSRASEPRIVLYGDLVQKSRSYPLPTVTQLTAEARDETRVGYEPIGNGSYFDFSRDILLCDHRISDQVTDQYLDGLAPRIQRLVFWDCFPDDGRVEGPYHYSVYLSACYRQPDFGKIEFDRFWFPNVDDMWIVKVGEIDPAWMVQVNPELPYRRRLQQLAKQFRYWVDENIIEMAPLDLSEPEAQAVLKDGRCGKEDCHELNRQRSIMLSKVAFLDGRYRAPDDGQKWIRIISWQAGEEKVVYENRMRWVVVERILTFDLQRDGWSESGVEVRRRSIQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E589</accession>
    <name>S0E589_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to myosins, conserved, ubiquitous membrane protein required for cell viability</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431945.1">
        <property type="nucleotide sequence ID" value="XM_023579036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E589"/>
    <dbReference type="STRING" id="1279085.S0E589"/>
    <dbReference type="GeneID" id="35399264"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05785"/>
    <dbReference type="HOGENOM" id="CLU_003271_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1092" mass="119685" checksum="8E06094F50A6D804" modified="2013-09-18" version="1">MSGVYALGTSHITDLQNVDVSDPPSSRPLSQCDLAFGTCHDQLESMIANVTPARNVQVTLQILSALMEKLHKDSVLIAPFVLKILDTVLRSDDITMIESSLPTFAAFCDYHDAAFLMADQTYLRQYEEIVRLYVQLASTKPAPGKESLTTPVKVRWRNAGLEAIRSISTADALSSITGSQMDVIMPRILENLWSETPDFLETLHQRLETEEKVDTEKQLRRRTSIATVGTDGANDPNPVALSGTAGDVDRLAEEEVGVLALQCLKSIFIVPTRSQIHGATVSLLGFIQEKVAQGNAVVELHDDRERDSGWAIVIYGIISRWAPVQDRYTILVAALETLLRIPVQDSTLDEQLALVTIMSSLLRSDVNLIGLSMMDVLLGLIKQMRKLFRMRTPTSQSDDGSPSAVESESVVRQKTKHLVGRLELCIGDLATHVYYADQISDMISAIILRLKPSRSASVNSSPGGEKNGNNEAGPGASTIELSDSQQLDHYFSLNTGRVSGLRAIKEILLVANPQKKLTGNMGLSRNPVPIYIWEGTHWLLRDPDGHVRKAYMDALITWLDRETSFANEIAVEEKLPRSRSSLKINKETRRAVSNASHREQGSKPRHSQFLALLHLVIYDNALQYVEYENDLVMLHILLTRLVLQLGVNAARYGLPMIYRLQEDIQEIDTPLYKVRTAALCHGYFWALTEKFDFKDSDIGIAIEQEVARRRRKGFWVQGITMPPPEVDAVGLPGEARPQPDWDSASLEREEILPFDDREALVEYIVSHYHDSLQVPPGSPGPSPGRVLSGPILGSTLTGQDQPDSELPAVFREQMLADWTRDAAGAMLAAAGKSESLAGSKTETSGTHRGHLTVKTNGNGHANGNGPTSPYGSQYNLMRPHSSHGHREKDREGTIPRHRKSSLRSAASPAHSAGNRGAVASVDQLKLVLSGNPPPKTAIIGDDDSGDSMVSYDYSPSEMSFNPATQNDQPSSPTSTKRPGTASKRGPLSAHPPLGAAPNLHDDNEDEDESVPPVPPLPDVNLLGGKRSPIQSIETSFQDKSARRSLTSRGGDGTRPKSVRSQNTKTMDLQDLLRGIDSRPSEGSLGNVTKPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5L3</accession>
    <name>S0E5L3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable 40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431077.1">
        <property type="nucleotide sequence ID" value="XM_023578238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5L3"/>
    <dbReference type="SMR" id="S0E5L3"/>
    <dbReference type="STRING" id="1279085.S0E5L3"/>
    <dbReference type="GeneID" id="35401407"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07930"/>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT68997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="151" mass="16058" checksum="BAD1B2C97388A7F8" modified="2013-09-18" version="1">MAPKKTTTRAPQENISLGPSVRDGELVFGVARIFASFNDTFVHVTDLSGRETITRVTGGMKVKADRDESSPYAAMLAAQDVAARCKELGINALHIKIRATGGNGTKTPGPGAQSALRALARAGMKIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5T6</accession>
    <name>S0E5T6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to sugar transport protein STP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_06098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432230.1">
        <property type="nucleotide sequence ID" value="XM_023579385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5T6"/>
    <dbReference type="GeneID" id="35399575"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06098"/>
    <dbReference type="HOGENOM" id="CLU_582711_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF80">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="234"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT70151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="469" mass="52061" checksum="4D7E74F7F8F2D5DE" modified="2013-09-18" version="1">MATLYTCSPRGLTSHKFWDESEETVWSVVASIPPPSPPQVVAPMEQEPCANFSYVRVLKVVEAAREHLLGGLYGHLPHCELDWSLDDDKPRCRVVGMDCYGMSFTRPESLKRHLLRAHTKHEAQLAREWVEAPSSSPQPSPSLHQPPTPIAPALEMDFVEVGGELEAERALDTSQSAVAAESGIPIPSSKRSFAPAEIPDMGEERESAPRLPPHLPTAPGWMIMFKVPQWRKRLMLGTLVQVFTQFTGINVIGYYQTIMYEKLGINGKTNLLVAGIYNCTGPLANLFFITFISDRIGRKRPLIYGIIAITIALILESAVNSQNVDGSHRGLSIAGVAFLFCVTIIFSLSFGPVSWTYMSEVMPYQIRGKGCAFATGIGNWLVSTFWNQVSPFALEELGWKFYFLFVAFNLVITLPTLIFAFRETKGLSLEEIDLMFGDRALGNLPADIEKDGGVIAVTNTHDERPRQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E655</accession>
    <name>S0E655_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431287.1">
        <property type="nucleotide sequence ID" value="XM_023578486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E655"/>
    <dbReference type="STRING" id="1279085.S0E655"/>
    <dbReference type="GeneID" id="35407750"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14298"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="68"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="5">
        <location>
            <begin position="301"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="495"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="727"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="760"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="826"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="859"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="895"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="928"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="961"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117877" checksum="9B69F97DFD257123" modified="2013-09-18" version="1">MKGFGTKPPPGRGAGSSAPQNFEHGVLKTPPKGILQCTEPVSNIYRCHYLLCPHKVVIPQEAPESPCSYKVKTYKEGRMACVFFYFSQCDPNQPSVPQLWASLLEQLIQQVGTSDNIAPELHSRFCQSWLGDFIYPTAYASLFYQQASMFKTVYVVIDALHLCDEYCDGGTTQTILETFSELPENVRLLFTCNNSPQAKGFGAQQKIQVKPNPADVEAYVRRRVSLSTKLQHLEIESLLNTIIDHTQESEMFIVAKMHLDRLEACRSLASSRNMPNLSLNLSEIFENSCQQIKRSAPADISLAKHVFTWVVYARDDITMDHVLQSFAISTRMDRQDRKLYLNLEYLLRVCDNLVTMDDEKNTLRLVHESVRECILRNGLLAEQPDSVIARTCLECLMSEDTDDVSNCLLFYSATFWASHLQSVIIQDCKELEDLAMTFLCSAAQLEKMSNTIRENDHGRTVDGMTGLHAAAYFDLPQLVHGLVNNGIPVNSSDSGDETALHWAVSYGKLNVVKQLLKKSHADPNVGDKRKETPLHKLNMGPLGTQFEIAKALINGGAEVTIKNNQNFSPVSTAIQFGPTSIASLFISSQKDVNTEFEQGWTFLRAVFYYGHGVAESVDQDKKSPGSMARHRAVKRHLDCLVDLLLDKGVKLDQPTTNGWLPVIHASRNGSVLMLRKLLEYQPNSDLVNKTKTAKGKSPLRCALKYERWSTAQILVHHGANVNEVNNDGWSPLIHVTKRNQYEMVQFLIQKGALVNSTDNHGLSALSHAVNNGNKDITWLLIMNGALVNIPARNSLSNIEKALQDQDLSIAWLLCVHHADLEQTDDQGMTLLHRASREGNLRNVTFLLDRGMTIGTADHEGLTPLHHAVLRQSREVVELIASRNTGSRFLDRPDKNGCTALILATRKVNIALVQILLRHGSSCEIKDRKGMTAIHHAASLGFREALQILLPKVKDINLADKMGNTAIHHGVLGGKANIVRFLAERKADLEVLNVEGCSALILAVLKDNPETVRELVRVGANIYTEGRNGCSAMDFAEHQGNYKSRRVLIEAIQPSQLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6P6</accession>
    <name>S0E6P6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432444.1">
        <property type="nucleotide sequence ID" value="XM_023579643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6P6"/>
    <dbReference type="STRING" id="1279085.S0E6P6"/>
    <dbReference type="GeneID" id="35399807"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06330"/>
    <dbReference type="HOGENOM" id="CLU_041481_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180027">
        <property type="term" value="P:inner nuclear membrane-associated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000058">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT70365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="264" mass="29248" checksum="1527CDBD4A631166" modified="2013-09-18" version="1">MASKGATKRLTREYKTISENPPPYIVAHPSESNILEWHYIITGPEDTPYHGGQYWGTLMFPPNYPFAPPAIRMHTPSGRFQPSSRLCLSISDFHPKSFNPAWEVSTILIGLLSFMTSEEMTTGSVSSTAAERRSLAARSRWWNSTGNGTHSKTFAVQRGNIKAGDGGAKFRTEWPEVDAENWEWMTKNKVDPVSGTRLDSDNSGSCRPQLGISGTSGHQTQAVVDVVNQQRDASTGWIYRNKLLVAGAAFFFYVLVARLVSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6X1</accession>
    <name>S0E6X1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430358.1">
        <property type="nucleotide sequence ID" value="XM_023577261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6X1"/>
    <dbReference type="GeneID" id="35400529"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07052"/>
    <dbReference type="HOGENOM" id="CLU_080768_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="301" mass="34896" checksum="12B425AC5027F36C" modified="2013-09-18" version="1">MTSTEDSGSSHFRLEGLPPELRDLIWKFSLPDCRLFHVKKTSTQEPATNPTVDELFFRFHIHYAPPIALRICRESRAVAQREGFFLSPHGDNPGVWFRPEKDILYFDRNQRVTLKAKPHNSIVTIHGYDKVLNVGIEWRAFFRDVPRPAAGETMAEYWRSSIESLYDFMPGMRTLNYILPELRHKGGMVWGREPYQAQSYTAVLLPLPERVKIPWETTRNRGNDRAAMLSEFLFNASHGNRDTTPLMVTWGEVKKDIEKGLGEDPERESAGHYPLEVIGWWLIRDGIPETQENPQVQRFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7E7</accession>
    <name>S0E7E7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_05593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431767.1">
        <property type="nucleotide sequence ID" value="XM_023578821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7E7"/>
    <dbReference type="STRING" id="1279085.S0E7E7"/>
    <dbReference type="GeneID" id="35399072"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05593"/>
    <dbReference type="HOGENOM" id="CLU_147114_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT69687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="117" mass="12456" checksum="6B6FF22FCFC95604" modified="2013-09-18" version="1">MATAPAPALNAYRHLMRAARIAFQGDAPILSAAQLQIRNEFRQKASVDAADASAAIKHAEEVAKVLRQNVVQGQRTEEGKDTFKLRIHEDIERGDNESIKTAGKGTVGGGCCGGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7K9</accession>
    <name>S0E7K9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432968.1">
        <property type="nucleotide sequence ID" value="XM_023580141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7K9"/>
    <dbReference type="STRING" id="1279085.S0E7K9"/>
    <dbReference type="GeneID" id="35402561"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09087"/>
    <dbReference type="HOGENOM" id="CLU_010794_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000080">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT70889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="767" mass="84935" checksum="AE554254272FBD96" modified="2013-09-18" version="1">MAPVPALLWRSLRAHQVYGANTDVGKTIFSTILCNSASKRGDKTWFLKPVSTGAADEADGWCNHIQRYAPSTNHETLFQYDIPCSPHIAAKASGKPIPSDRDVLTKIYDTTSRYASDGPGWLFLETAGGVHSPGPSGTPQADLYAPLRAPVILVGDSKLGGISQTISAYESLRMRGHDIESILLFQDMKYENYQYLRDYFAKQGGISVDTVPEPPTRLDNEQEDIEQMKEYYAARNVDHVLEALDKRGKDRISRLESMSSKASKSIWYPFTQQKLVTADTISAIDSAHGDYFQVLNPSSPNLLQPAFDGSASWWSQGLGHANSRLTLAAAYAAGRYGHVMFAEAIHEPALALAEMLLKGADNPRFSRVFYSDNGSTGCEVAVKMALRAARLRYGWGPNDNVHILGLKGSYHGDTIGAMDCAEPCVYNEKIEWYEGKGYWFDYPTIQCVKGKWVVQVPEGLRDELGHDSDLRSISEVFDLESRLNTEHYRKYERYIECVLSKLQASGRKFGALMMEPIILGAGGMLFVDPLFQRALVDVVRRSPHLFGNATSPKDPLSWSGLPVIFDEVFTGLYRLGRFTAASFLGTDADISVNAKLLTGGLVPLCTTMASESIFDAFVSDDKSDALLHGHSYTAHAVGCQVAVESVREMQDMEKRGEWEWAEKDWEKNTQAWSVWSREFVNNVSHNQQVLGVWALGSVLAISLRDDDGVGYKSLAAKKIQTHLREGAGTWNAHSRVLGNVFYVMASQKTSRQSLEELQGLLLGALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7M0</accession>
    <name>S0E7M0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430538.1">
        <property type="nucleotide sequence ID" value="XM_023577471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7M0"/>
    <dbReference type="GeneID" id="35400718"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07241"/>
    <dbReference type="HOGENOM" id="CLU_044876_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF5">
        <property type="entry name" value="ISOFLAVONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="310" mass="34339" checksum="03D1BF68ED1EDB06" modified="2013-09-18" version="1">MMRIAIAGGSGLGYLLASHISKAANAYQVVVLSRSSRPEYATLDVQVMVVDYNDENSLAYALHGVNLVICTFSGGEQINLITAAVQSGVQFFVPSEFEGSLEKRPENDQLDPYSYSSQARQHLRRCARSSQMKWTVFSCGIFMERFLPRGLGSLAIGYGSNLANVGSYVLDMNTYTAECVEKNPRGHTVRVCMTSVYDVAQFIVAAIDLGPANWPREFTMRGDRLSLRDIVGQCSRTLNAAFSLSQWQASDIAGLMSGFYQQGDYAKVAFYRQLQATVEGRYDFGHTSLNGLVNVQPRSFRQWLSDQFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8Q2</accession>
    <name>S0E8Q2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to translation initiation factor IF-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433084.1">
        <property type="nucleotide sequence ID" value="XM_023580279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8Q2"/>
    <dbReference type="STRING" id="1279085.S0E8Q2"/>
    <dbReference type="GeneID" id="35402436"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08962"/>
    <dbReference type="HOGENOM" id="CLU_062478_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 3 C-terminal" evidence="4">
        <location>
            <begin position="181"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="293" mass="34045" checksum="7201F76359BB9FDB" modified="2013-09-18" version="1">MNSFACLQSSRRALYRVFVQHEGLLTRQFQPPRALSIQNRFFSASQLKARNKKAKKREDETEVDLFADEGQDRGFDRRYTTQEEFEKSGRDRLPQDFEITDPKIMVLDNGVFDGPLLTKNVMSRLPETDSLRMVTPYIPGDLKKDKPTQYAICKIVNKKEEYERQRELAQRRRLSKQTTPKLKEVEMSWAISEHDLGVKTQQLVGFLSKGMKVELILGFKKRGQKKRTSEDTTEEVYAKVNKLIEQLGSREYKPRDGEVGKTMRIYLEGITKQARETLQVKEESPEVDAQKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0E931</accession>
    <name>S0E931_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_06252</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432371.1">
        <property type="nucleotide sequence ID" value="XM_023579556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E931"/>
    <dbReference type="STRING" id="1279085.S0E931"/>
    <dbReference type="GeneID" id="35399729"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06252"/>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_1"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="211"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="239"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT70292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="544" mass="59844" checksum="DE0557FA48E85961" modified="2013-09-18" version="1">MSETLDAAPPHATFDTVLVLDLGSQTSHLILRRLRSIGVYSEMLPCTQKLKDLSWKPVGIILSGGPSSVYSPDAPNVDPLVFELGVPVLGVCYGCQLIAWRVNPNNVAPGVAREYGETSMAIRKIGNHADRLFEGLGDSLNVVMSHFDKLVHLPDGFKTIATTKNSEFAGIAHDSQPVFGIQFHPEISHTERGTDIIANFALKICGARADWKMDNFSEREIVRIRKLVGDKAQVIGAVSGGVDSTVAAKLLTEAIGDRFKSILVDTGLMRLNECEQVKETLDKHLGINLTVVDGSDLFFSRLAGVTEPEAKRKIIGETFIDLFEIEALRIEKEAENTPFAGKVEWFLQGTLYADIVESLSFKGAASSTIKSHHNAGGLPARMQNGEAHLKLLEPLRELFKDEVRAFGRQLQIHEELIGRHPFPGPGLGIRIIGEVTRERVEIVRKADHIFISMIREAGIYDEVTQAYAALDTNRAVGVQGDARAYGYICVLRAVTSLDMMSAEPYEFEWSLLKAISRRIVNEVDGIARVVYDTTSKPPGTIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E934</accession>
    <name>S0E934_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433229.1">
        <property type="nucleotide sequence ID" value="XM_023580456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E934"/>
    <dbReference type="STRING" id="1279085.S0E934"/>
    <dbReference type="GeneID" id="35402278"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08802"/>
    <dbReference type="HOGENOM" id="CLU_107716_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000050">
        <property type="entry name" value="Dual specificity phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="146" mass="16381" checksum="53D050C95319DD2D" modified="2013-09-18" version="1">MTTIASLKRLSAKSLSEKILEEVNATDPTFAVIDVRDNDYIGGHIKGSTNIPAHTLDAMMPTLVRRLKDKKTVVFHCALSQQRGPSAALKYLRERDGLLKSMGEDPKGESGQDVYVLDRGFSGWQEVYGEDERLTEGYVKDLWDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E945</accession>
    <name>S0E945_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433473.1">
        <property type="nucleotide sequence ID" value="XM_023580749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E945"/>
    <dbReference type="STRING" id="1279085.S0E945"/>
    <dbReference type="GeneID" id="35402014"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08538"/>
    <dbReference type="HOGENOM" id="CLU_096859_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="126" mass="13372" checksum="46EC46F569DA0828" modified="2013-09-18" version="1">MVYLKTSQEWLDQSMALLEARPATTLITTTYKLKPGPTRPDADGNTPVTKPPRGALVLKARRRSRRLIHASLGRLGRSMAAVPDVPEVTMADGDGTIPAEESQAATPTPQAAQGGGGGKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9C2</accession>
    <name>S0E9C2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinetochore protein mis14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433575.1">
        <property type="nucleotide sequence ID" value="XM_023580878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9C2"/>
    <dbReference type="STRING" id="1279085.S0E9C2"/>
    <dbReference type="GeneID" id="35401899"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08423"/>
    <dbReference type="HOGENOM" id="CLU_070604_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24975" checksum="1B4909AAA958CF14" modified="2013-09-18" version="1">MDSESVVAQVQRKIELQTPEDLSYLIANVRRAAAERLNEAFPVVEGNDGEDELRNQIEKLVNEYIDKTFSLASPNLSINGLPVSPDSFLSESNVEPDTIYEPFDTRKRRRVADLITQEEKLLEDVAALKRSVPATTAEAQAEQLRDILKRDDDMLEARKQQIIAEAAEVDLNVQPLERQDGVEKGFRRAVEGLGRLKRDMPAVVAKMERARVAGEYVVTQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9C8</accession>
    <name>S0E9C8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to beta transducin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433563.1">
        <property type="nucleotide sequence ID" value="XM_023580865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9C8"/>
    <dbReference type="STRING" id="1279085.S0E9C8"/>
    <dbReference type="GeneID" id="35401911"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08435"/>
    <dbReference type="HOGENOM" id="CLU_000288_138_18_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="224"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="611" mass="69456" checksum="788AB21BE4A2C12E" modified="2013-09-18" version="1">MRLLNVSTLQLKDFIGHVPPYAILSHTWTEEEVLYSDIGTFTAQSKKGYPKLVGCCSKAAQDGFDWVWIDTCCIDKSSSAELSEAINSMYKWYQKATSCYAYLQDVTTEACTLADVFHITEFGRSRWFTRGWTLQELIAPQIVELCSKEWIVIGTKKSLASSIESVTGIPITVLRGSHPSTYNVAERMSWASARTTTREEDLAYCLLGLFDVNMPLLYGEGAKSFIRLQEQILRQEEDYSMFAWTLQQDNPIADSETSSTGFLAWSPAQFSKNDIHAQAPKHTQDQKMVDHGHAFPPPSEPELDVEKQSIEYRVLHEKDYGRMFRGQRSIVAMQSVLSNPLEFTSRGLRINLHVLFPTDLDLARIAWLSYETEDSLVCVLIERDYESARRRVYCRVKSSSLIGLPKTLLPYFRPMELFIRHSGYFTGSNNFGMVPPSSMFSSKQLQILTQVSSTTTRSLDIVLTYPSDDWMKRQTPIHESPFKALWVVCSHGSQSSLFRIDIMISTEDASCTIRELSQSGSDIDESRKNAFFRACVQYKKSFVAHTDRAVKRSARVSETVFSAVLRKMPSSHEDLVTYELRVDAWDVGGCPSWVQLSLLQEHKEVDEVKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9D5</accession>
    <name>S0E9D5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Related to vacuolar membrane protein HMT1 (Heavy metal tolerance protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_08661</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433359.1">
        <property type="nucleotide sequence ID" value="XM_023580612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9D5"/>
    <dbReference type="STRING" id="1279085.S0E9D5"/>
    <dbReference type="GeneID" id="35402137"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08661"/>
    <dbReference type="HOGENOM" id="CLU_000604_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="359"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="691"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="255"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="947"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="997"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT71280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1009" mass="114200" checksum="0866A2BDAE399A01" modified="2013-09-18" version="1">MAATDNTVIIPLSGVGRDDLPLADYILRKTQYLYALILLTAFISCAAWYSVVNSKKQEDLVQSTVKGPGGKPLPITKRKRARGDGDRKIGPGFGRTAKNVFRYLAFVVFMTYVGSAGFMFYHAFWYEDPYQWSNEGLPWAGEWSVVHVTGSLFFYLYILISLFDWRKGPNIVHFIVWILGFIGEIIMFSTTAVAAFDCHFFRSVKDSGSDKERNCVDYWTKIDLVLYFVRILHLLALIGVFSLAWIRKARDTDEKKAEEANPAESTPLLNGNRRSYDTNGQAVNGQIPNGRDTNGRRGRGRTMSNAHKTPNFPKKEEPAAFYRPEKLPHKTWWEYLKGYSLFFPYLWPKDSARLQINVLICFILVMLQRLVNVAVPMAVKQVVNDLEDVIKDVQEGERLSMDNFPLKDFLILGVLWILQGQSGLLGSLRSILWIPVSQYSYRGLTTAAFNHVHSLSLDFHLSKRTGEVLSALNKGSSINQFLEQVTFQVFPMLFDLFLAISVFYYYYGPLYAEINLVDTCWYLYMTIKMASTRADQRREMTNADREEEAVKNDSISSYETVKYFNAEDFESRRYQGKVAVFQNAEAKVQMGMMMMNICQTVVFNLGRIIAALVCGWQVAMGMDRRTTGDWFMVVSYLTQLQGPLNFFGTFYRTVQQAMISGERLLELFKIQPTVVDTPHAVPLGKDFQGHVRWNNVSFSYDRRKPALRNISFECLPGTTTAFVGESGGGKSTLFRHMFRYYDCDEGSIELDGKNVKDLTINSVREKIGVVPQDTTLFNETLMYNLKYARPSATDEEVYEACRAASIHDRILSFPDQYSTQVGERGLRLSGGEKQRVAIARTILKDPRIIMLDEATSALDSHTEQEIQDNVWNIGQGRTLLIIAHRLSTITHADQIIVLNSGTIVEKGTHEELLTAKGRYASMWEKQIRAERALNVAREAQLKAARALRKAKMGPKRNSDGAIDSYNGLGSSGSISGSGSQGHEDDTHTSSSSCSDAESSHSEEHSMERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA16</accession>
    <name>S0EA16_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pesticidal crystal protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431413.1">
        <property type="nucleotide sequence ID" value="XM_023577061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA16"/>
    <dbReference type="GeneID" id="35400349"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06872"/>
    <dbReference type="HOGENOM" id="CLU_042073_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001907">
        <property type="term" value="P:symbiont-mediated killing of host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.10">
        <property type="entry name" value="Pesticidal crystal protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038979">
        <property type="entry name" value="Pest_crys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005639">
        <property type="entry name" value="Pest_crys_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036716">
        <property type="entry name" value="Pest_crys_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37003">
        <property type="entry name" value="ENDOTOXIN_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37003:SF2">
        <property type="entry name" value="PESTICIDAL CRYSTAL PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03945">
        <property type="entry name" value="Endotoxin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56849">
        <property type="entry name" value="delta-Endotoxin (insectocide), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pesticidal crystal protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="455" mass="50734" checksum="EFAC3863D996DF86" modified="2013-09-18" version="1">MDLEDPNEIGKFIFGILASGLELIPGYGDALAAVLNLFSSLIFQPKSAADIWEKLFRRIEQMIDSKIEEYHLETLKEKLAGLDTAIGDFSTMVKKHDEGKDVTTLLLGSFASLHQTMIISMSEFTSPKYGVASLPWFALAATMHLKLLGDGIQHGQKWGFSADEVEILQETFDKLTTETAAVSHAEIASRHKLFLENLMLDDSKMTVHTYLSAMDDVTHAIPAIESSSYVTYAKATYQAGRVNVRPEWEGLSRYDTGADTGANFRAKMQYDADMTIHVLNYADFWPYLTGKPLTEEALTNLDREIFAGRGRYEPWGSGPFPPVKRGKNEQITAVYVGGITNVELLQIKYGDTWGAAYGSTAVDPASTTNLDTKAGEYLYWLDVWFGQKLGCAQFWLNNGKKLREVGRSGNTKGELWFADHQVTSVYGVNYEIHPPSGLEGIIVGFRPLFLKWDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA48</accession>
    <name>S0EA48_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_08413</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433584.1">
        <property type="nucleotide sequence ID" value="XM_023580889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA48"/>
    <dbReference type="STRING" id="1279085.S0EA48"/>
    <dbReference type="GeneID" id="35401889"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08413"/>
    <dbReference type="HOGENOM" id="CLU_032444_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="344"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT71505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="395" mass="44904" checksum="861F8ADF8C5A5F23" modified="2013-09-18" version="1">MGIKQLFSIIKEEAPDSIKEGEIKNQFGRKVAIDASMSIYSFLIAVRSEGQQLMNESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRFQRKQEATEGLEEAKETGTAEDIEKFSRRTVRVTREHNAECQRLLKLMGIPYIIAPTEAEAQCAVLAQAGKVYAAASEDMDTLCFNAPILLRHLTFSEQRKEPIQEIHLEKVLEGLNMERKQFVDLCILLGCDYLDPIPKVGPSTALKLIREHGSLEKVVEAIEKDPKKKYTIPEDWPYKDARDLFFEPDVRQADHPDCDFKWEKPDMEGLVQFLVTEKGFSEDRVRSGGARLEKNLKSSQQARLEGFFKPVPKTDAEKAAHKRKLDEKNEEKRKKAKQEKKDKAASKAKPRGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAB9</accession>
    <name>S0EAB9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to VTI1-v-SNARE: involved in Golgi retrograde protein traffic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_08353</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433639.1">
        <property type="nucleotide sequence ID" value="XM_023580956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAB9"/>
    <dbReference type="STRING" id="1279085.S0EAB9"/>
    <dbReference type="GeneID" id="35401829"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08353"/>
    <dbReference type="HOGENOM" id="CLU_075474_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT71560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="227" mass="25479" checksum="9BCFDFCE668F2FFF" modified="2013-09-18" version="1">MSNPLDTDAGSELFSSYEAEFKLIQADLNQKLDQIPELAGEPRKAAISQAERALEELDEQLSAMRLEKQNIPTSSRTKVNQRFRNYESDTDAARRKLTTLSSDRSALFGSRYTDDPAGSSDIHMEQRQQLLSGTDRLDRSTQRLKASQALANETEAIGAGTLADLNRQRETIEHTRGIMLESEGYVDRSVKTLRGMARRMATNRIITISIITVLVILIIAVIFSKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBE6</accession>
    <name>S0EBE6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434048.1">
        <property type="nucleotide sequence ID" value="XM_023581335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBE6"/>
    <dbReference type="STRING" id="1279085.S0EBE6"/>
    <dbReference type="GeneID" id="35407490"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14036"/>
    <dbReference type="HOGENOM" id="CLU_007383_19_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050005">
        <property type="entry name" value="DenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF043036">
        <property type="entry name" value="ErythonDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="320" mass="34290" checksum="90EA9E608F63A593" modified="2013-09-18" version="1">MTQTKDHVLITGAGGFIGQELITCLLKDMPNALFTLTDIITPPIPSGADHQVTSLKADLTDPSAVTSLLSNRFSHVYILHGLMSGGAEANLDLGLKINVDSVRSILDVLRTEYPGTKVVFASSCAIYGQTDLVTEFGTLPQPKSSYGIQKLLVELLINDYSRRGLLDGRIVRLPTVIVRPGAPSAAASSFASGIVRESLQGVPNILPVSRDLELWVCSPATVIKNLIKIKDVPKEKFGDSRVVNLPGITVTVQEILDALKEVGGEKALAQIEEKRDPAIEAIVNSWPAKFDVSRAYGLGLEADGKALDAVKAFHAKIAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBS7</accession>
    <name>S0EBS7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431948.1">
        <property type="nucleotide sequence ID" value="XM_023579040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBS7"/>
    <dbReference type="STRING" id="1279085.S0EBS7"/>
    <dbReference type="GeneID" id="35399267"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05788"/>
    <dbReference type="HOGENOM" id="CLU_010194_13_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF16">
        <property type="entry name" value="BACILYSIN BIOSYNTHESIS OXIDOREDUCTASE BACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="354" mass="38390" checksum="A279F0F3F4D6C33D" modified="2013-09-18" version="1">MEPTNDIKGLIRQSPPVDVSKPYDATTLKGKTIVITGGANGLGSYMVREWASHGANIIIGDVADAAGEKLVAELTTQYPDSAFAFQHCDVTDWESQVGLFETAVHVSPHGGIDIVVPNAGIILPDVSIQFEEPALKNGRLPKPNTAQFDVNITGAAYTTHLAMYWLPQNGSSPRDRCLLLVGSLASLCPFPTQTMYTMSKHAILGLFRTLRATSFRSGVRVNMITPYYVSKSNMLKLPIEAAFLSGTAGGAMIEDVIDAATRLIADEEIAGRALCVGPKLKSAGVEGVEDVDALMTVQDSENDGQGRAVWECYADDYDNVDAFVKRFILLLNAAERVKGWFGIFTDIWGMLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBY4</accession>
    <name>S0EBY4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to gamma hydroxybutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_12266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434477.1">
        <property type="nucleotide sequence ID" value="XM_023581851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBY4"/>
    <dbReference type="STRING" id="1279085.S0EBY4"/>
    <dbReference type="GeneID" id="35405722"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12266"/>
    <dbReference type="HOGENOM" id="CLU_035117_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF3">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="177"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT72399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="307" mass="32825" checksum="602E8158331FBC9B" modified="2013-09-18" version="1">MPPTLLWIGLGNMGRGMSKNIVEKGNLDGPLLLYNRSSQRATDFSAKFPAGKTEVVESLADGVSRADVIFSCIANDEAVQETFKAILEENVKGKLFIESSTIHPDTTDAIAKDVVAKGAEFVAAPVFGAPQMAEAGQLIGVLAGPAASVARAKPWFKGVTSSKEIDLSDKPYSKALTLKVLGNTFILNMAEQLAEAHVVAEKTGLGTEAIHQIVDSIFGGPYAAYSQRMLTGDYYNRDEPLFAVELARKDARHAMSLAESVGVRLRNVEAADTHLAMAYEHVGSSADMAGIYGAIRKESGLKYENDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC21</accession>
    <name>S0EC21_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434574.1">
        <property type="nucleotide sequence ID" value="XM_023581971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC21"/>
    <dbReference type="STRING" id="1279085.S0EC21"/>
    <dbReference type="GeneID" id="35405829"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12373"/>
    <dbReference type="HOGENOM" id="CLU_1102809_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485468" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="250" mass="25002" checksum="7EFA1020C2EC363C" modified="2013-09-18" version="1">MTTKMHLLILLPMVFFAVALPQPPPKYIGCISQTSTFSATTLPSPFTTHQCLQACAAKGSLVAIGSGTCYCDNGSASASFDLVDETRCTDLCIAGDETSGKCGGQDVMSLYQIDGYDGGCAKNGTIPPVVQTPCTLCGQATLVPTPTAVQKKAGSPCPFEGCKAAPAPIATPARNSTAKICPSGGCSSSGQGGQSGSGGAGGQGGTTDTQNGSSGKGTKAAPGIVSESPRLYSSSILSAIAAVIFGLRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECE6</accession>
    <name>S0ECE6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434622.1">
        <property type="nucleotide sequence ID" value="XM_023582026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0ECE6"/>
    <dbReference type="GeneID" id="35405878"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12422"/>
    <dbReference type="HOGENOM" id="CLU_000570_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1284" mass="147010" checksum="DA899668B98DF22B" modified="2013-09-18" version="1">MAAEQESQSLNPETKLGKHISDSAKSLLHELLRFTNSRTFIKEGLRSIMHPRMTIRLLGSKRIVIECNDQGIPEADMDGMCEPGSEGQSKTFDFRKIIAACKKVHLQSESSSLMFHYNIFDSTDKTLYISKRRESLSAYVFGTRITLLLHDQGNRKDVETLKNIIHRQFEELHDATLIFLKELKILNVEFCGIDEKVYRGFTWKKNEVDQHLLQVSMNKDEYGESRFDLQRYHVTEQPLLDLATTVVLAFPLTIDFEPETKKPIVRKLFNFVPLRTWSHGFHVHCDFEIQNMRHNTSTPSSAQMLRFSDHVATALFKAILQFLDHPKLCYQWPMFLSPRCSDSDPFGVTLDTSIRLWIAQNPIFRSRTSRQWRLINHLSFLGTEFEDDDSNPLLESPMNDVFLSREYPPTVTPALKRYGLATFTNTQFLDLLETDLKSPDSKIHKNASLDWKNALARCLSRTFVNDRNSQMRTLPLIQLTDGTWTSVSSGPVYFSTAGDVRVPDALGCRLASHLASREFEQRSLYEKLGVTQATVAQVRQMIFNSFKSSSALSLEEVQRYLHFLYLTHESSNSDNDQPYHEVRVVTGDMSLRSPQSAVIYLMRTSHPYSLESLLDPAFLVANFDTNILHTEISNNGPRQPSPSHPSWKSWLCTCLGIQESFSLSGPKSDKESEFTKHSSSTPEKDDALCLSLDYVAKNSSAKFLGVLEHLWSVKEPALLENPVVLSKIKGCSAQALCGVQFPVELQETWLPFPHLKSYLKACMEHPGNFPFLKLNKEESTIHKLVNKWEFLTTHFGVRRDRDMIFVVNVLKCVWRHSGTSLSSRQIERIFQMYVDIGKMFSLLKSEEKSQALEFFDDCGILYIDESGPTWISSSSCLWAAPADMVSAHSLKVLYEKMIHDKHDFKIVADLFQNGLHIQDAAAEDLVQELSTLRDEGCEDLVRVSSIYKYLDKMTLSQDILLEFRKSWLIYLEQNDRFSWFSASGCFWSDADTTGLNRSLKDCYPDLREFFVVKLGVCASAYDSLLNETSDNPDLIKEIILKFGKEFGECVPQIPAKPLQTKKILPVRHPDGTVVLCSVDTDFAIADRIRLAMLLDNSIKILNFGLDEVRHLWPFFEWLEIADRRLSLCVTEWVTRTPDGPSVLNEPYSRDLRRKAHYITRVADTFNIFATYGDPTCLFQRLKTIRVVEVCGIFSEMEIVQDDKAIRSAPQPTTAFVSDDDLDFTIYVSKDEMEKLFSFLPRILGDWLRQDRYPCHTFEVISSLTSIIASDISVLDEILEDQGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECW2</accession>
    <name>S0ECW2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome b mRNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_06185</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CBP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432312.1">
        <property type="nucleotide sequence ID" value="XM_023579482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECW2"/>
    <dbReference type="GeneID" id="35399662"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06185"/>
    <dbReference type="HOGENOM" id="CLU_136894_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT70233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="123" mass="14320" checksum="CDB72C26AAD2EE62" modified="2013-09-18" version="1">MAAKQPSSRWWFWTKVLMGGAAVAVGGPAFTMWLTPTEEELRSRYNPELRKKSLENREERQQEFDDFVTRLKEYSKSDKPIWIVVKEEEERKRKAAAAAAKASQKDADTRREEMRREAGLDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED21</accession>
    <name>S0ED21_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_12387</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434588.1">
        <property type="nucleotide sequence ID" value="XM_023581987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED21"/>
    <dbReference type="STRING" id="1279085.S0ED21"/>
    <dbReference type="GeneID" id="35405843"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12387"/>
    <dbReference type="HOGENOM" id="CLU_020492_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF107">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT72510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="61409" checksum="8C2FAB67044DDE7B" modified="2013-09-18" version="1">MDVINTIIELSLQMRGPFLGTTLAACLLIVILYRGYDHRRFYRDLPGPPHSWLFGHIKVFGQVAALMPPNTHPQLFYTELARLYNLEEIFYLDLWPIASGVVVIIDPKLMDNSSLPKPLPIPPFTAVFLKPMFSEGTMSAANGALWRKMVTAVSPTFSMSRVLGMTNIMIDECLLFQEKLDELAVGGDVFSMEELVAEPVFGIVSKVTFGETQHSQTAESQILKHLRDLVNLAQGETDPLIAYKPMVQIPRRWKRHRVVSRLHYSLRGKVNKCAEPTVQEGVVPSRQNPRSIMDLLVREHAEAVLEERKRGVYGHSEISNSEEEILFSNTSTNSLCFLFMLLSKAPGFVKKMHQEHIEQLGTSPQVTLLANPNMLRRLPYTEAVVKESLRLYPLGSDLKHAPPGTTITTHDGRRLPIANGLIVTVSAHTIHYGAHIYPDPTAFRPERWLDQDKTIPSDYFRVFGGDGRTCPGQNMGMNILKIVMVMTMSKYTFECAELKPNREPKTKHTNFDLVFGDMAFQQLGLDGRPRDGMMMTVRQKAQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDK6</accession>
    <name>S0EDK6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_06456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432557.1">
        <property type="nucleotide sequence ID" value="XM_023579782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDK6"/>
    <dbReference type="STRING" id="1279085.S0EDK6"/>
    <dbReference type="GeneID" id="35399933"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06456"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF10">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="5">
        <location>
            <begin position="86"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="300"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="581"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="208"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1222" mass="137787" checksum="444D71DAC5AED33B" modified="2013-09-18" version="1">MELSRPAGAQIVAASRSRAGKDASAAPVEELEGTVAGFQAILTDDDRKKLQQLKTTSHDSQSIIAFTAELDLLDKNRRGKSVASRLASFLQTIEQFTPIVDTYIQSNPDIAALIWGSIKLTFMFLANFASYFQSFVELLHGFGSLCTRFAQYQVIFNESSRLRRSVCEFHTSVITCCQQIVLAIRRPLKNQLLKAITQSFQSELRSYVEDIRAKAEEVQGDIQLVKAQCDREEQQLQTTERKEATDHRKRFRAWAAEMEIFQAQRRRDALEQRRRRLLEDLSSFNFTSAFNSTRNKRHIGTAKWVFDTPEFQQWVKFNGPPVLHITGKIGSGKTVLSSSIVEKLSQIRPPQQFVSFFFARFDDPLSLYAETIIRSCIQQLVSAIDMDTLDPKVVSALDEQLSQAKLALFSFEFLSDLYLSAAKAIKQWFIVIDGLDECSTDQQSKLLKFFQGIISRNDTTSNISVVFASRETCTNTIRSIFPQSQRLVTGLESTSVDIDSYVDDIIINKLSTGELVVSDPRLLKEILTTIASKEQGMFLWAFFVIEDICSGKTDNEIRQALQNIPGDLPATFDRALSRIVQKRNQDTAKKAFMWTNATLQPLTLSQLREALSIKPGQHTLRQEDLISGIERLPTWCENLIYVEETDNTVRFSHHSIQEFLLASDSGEHEALHIDPDQCDKLAGEVCITYVNLDNFQTTLAERKREPQTPSALKIDPSGIAEQTIQSAIQGGVGTRVGRLARQFVKTSNTKKASTQREFSLSSPMPVTGKAQGTTDYPFLEYASANWFKHTKYISKTEPEIWRLFGQLVQKPAQHSQDEPWHSAEWKKEAIAGFTNHYDPISERYFHAMKTVCIGTFHESDNETDAGPNFSKLCLAFDYAERNGYYALACRSFQLLLEYSLMEPELEEVICILSVNKNYETCQNGCAGLITTRLNHGQLITELRKAIAEGIPYFPPLPDYGSHPLCHCADQPPHELKLDICQVLKSGYNPAIQRHLRPFAIVAEALGNEGHQNIPSILVLSKTCNEEEPNALLNATNIHGMHLIDILTQGLLSTENLGNNMVAFTVGRFVGYGTAPTRPQYQQRKPLASLPDSAVNTILLLNSLDTLYPSSEIPELPGSKELIDLHGETITAMFRRVVIPKLRSTYMASYMVQCLFGDFLNSDLQHIAHAHEDSFREAVWNNNWDIAAALLSIQPTFLDKFTGRGYFTSIREAVMCEPCQRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEE3</accession>
    <name>S0EEE3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pathogenicity protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432867.1">
        <property type="nucleotide sequence ID" value="XM_023579912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEE3"/>
    <dbReference type="GeneID" id="35400049"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06572"/>
    <dbReference type="HOGENOM" id="CLU_178684_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495896" description="Pathogenicity protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11343" checksum="59832EFC9E02CD28" modified="2013-09-18" version="1">MKFSIASTLLLANGIAAMPWSSLSAKQSNGEEITLRIQVSQPSSNHAVTPNHKGVVNVHNYEVCLKVCWPEEPTCPEGWNSKKFGDSDYPCWTCCKKTGDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEI5</accession>
    <name>S0EEI5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to monophenol monooxygenase (Tyrosinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434355.1">
        <property type="nucleotide sequence ID" value="XM_023581698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEI5"/>
    <dbReference type="STRING" id="1279085.S0EEI5"/>
    <dbReference type="GeneID" id="35405584"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12128"/>
    <dbReference type="HOGENOM" id="CLU_035914_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF116">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485545" evidence="2">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="403" mass="43728" checksum="968C5F27363ECC14" modified="2013-09-18" version="1">MRAGFISLLALNAAGVLAAPQATTVDSSAPEVTNLDELADLAAAAYETAQDLAGDKTKRASTCNWSNVRVRREWGTLSKTEKKSYIDAVKCLQSKPSKSPASFAAGAKTRFDDWVAVHLNQTQTIHYTGNFLTWHRYFTWLYEEALRNECGYKGTQPYWDWALTALSGLNKSPVFDGSDLSLSGDGEFIPNEPDIILGASSGLPPVYLPAGSGGGCVKSGPFKDMKVNLGPAALDLPGGGVAANPNPLDYNPRCLKRDLSDAVNKRFANATSVLNNILKPKTVLDFQMQMQGVPGTGDIGIHGGGHYSLGGDPGRDVFTSPGDPAFYLHHSMIDRVWWIWQMLNPKERVNGKNAVQGTNTFLNMPPSAETTLDDYVNIGWVGPERQIKDLMSTLSGPFCYVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEX2</accession>
    <name>S0EEX2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12287</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434495.1">
        <property type="nucleotide sequence ID" value="XM_023581875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEX2"/>
    <dbReference type="STRING" id="1279085.S0EEX2"/>
    <dbReference type="GeneID" id="35405743"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12287"/>
    <dbReference type="HOGENOM" id="CLU_059606_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="94"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT72417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="282" mass="30529" checksum="F7BA905E8474675C" modified="2013-09-18" version="1">MSGSGYDAVVDVDDEGDLGHTDLQEDLEFHTSNFNDTNPNTRKPPSSGSGLPPPATASTGSGSSKRFLWSMNFYAQFFDVDTSAVLSRCWAALFPRANFLDVLEGNPDLYGPFWIATTVILILFLGGTISQYMSDTGKGPFLYDFKLLSGAAGLIYGYTLFIPMALFLALRYFGSESANLLECWALYGYSNLIWVPVALISSSPISILNWVFVGIGFGISVAFLLRNLYPVLSATDRQVSKVLLVVVVLLHAGLALAIKILFFAHGSPVASKPDEGKGSSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEY0</accession>
    <name>S0EEY0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433007.1">
        <property type="nucleotide sequence ID" value="XM_023580187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEY0"/>
    <dbReference type="GeneID" id="35402519"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09045"/>
    <dbReference type="HOGENOM" id="CLU_2073346_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="118" mass="12992" checksum="EAB6879ACE8DF415" modified="2013-09-18" version="1">MEPTQTTAGKRPASDDGDAVIKHRAQTTSQNPSVPAPSMAYECSVPPGMAEAFGLLPSATSSEKLLLQRLESPAEECAREKREKQALETKNKLLEAEVRYKDEVIKCLRGTLERHNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF11</accession>
    <name>S0EF11_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_09954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435437.1">
        <property type="nucleotide sequence ID" value="XM_023568087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF11"/>
    <dbReference type="STRING" id="1279085.S0EF11"/>
    <dbReference type="GeneID" id="35403421"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09954"/>
    <dbReference type="HOGENOM" id="CLU_006332_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485857" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT73359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="601" mass="67247" checksum="73796E8098FC357F" modified="2013-09-18" version="1">MRLPTWIQPVILASSLLAQNTNALSKYGPEDQAVLKPNNDAVSRKPKTTLDGKKNIVFILTDDQDSVLDSVSYMPKLKEHIIDKGTSFVNHFTTTAICCPSRVALWTGKQPHNTNVTDVNPPYGGFPKFVSQGLNDNYLPVWLKEAGYNTYYTGKLFNAHTIHNYNSPYPAGWTGTNFLLDPGTYDYLNPIYQHNQEPPVQHKGVHTSDLISKYAHELLKEAIGSENPFFVAIAPVAPHSNVNLRRQPGNPSAPLMTIPIPLERHSHLFEGAKVPRTENFNPDSPSGVSWIHKLAQLNESAVSYLDDFYRARLQALQGVDEIVEQMTKQLEDAGIIDETYIIYSSDNGYHLGQHRLPPGKECGFDEDIRVPLFIRGPGVSSGSVENAVTTHIDLAPTILRLAGADLRTDFDGTPIPVLPTQENKRHEHVAVEYWGGAIAEGEIGGFDGKGQIFAQNNTYKGVRIVHEDYNLYYSAWCNNEHELYDIKTDPGQLNNLFPHDDAKASTEFLGTTTGQVLNRLDALMLVLKSCKGNTCIEPWKILHPEGGVASLKDALQAKFNAFYKEQVKVRFDRCEYGYLIDAEGPQVGYEYREGLEWHHWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFL5</accession>
    <name>S0EFL5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to transcription initiation factor TFIIF large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435558.1">
        <property type="nucleotide sequence ID" value="XM_023568346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFL5"/>
    <dbReference type="STRING" id="1279085.S0EFL5"/>
    <dbReference type="GeneID" id="35403188"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09720"/>
    <dbReference type="HOGENOM" id="CLU_025955_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="573"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="665" mass="73566" checksum="C3B7E6929A271F37" modified="2013-09-18" version="1">MSAPPPSGHPPANAPGYPNGAPKKQKPNPLRPLRKNPKANPLVSRRPPPRPTAQSASGRLNGTKPNIEEIRRQNGGWSEPPPPECKDIPIMTTKKDLLDGIRYHMMKFTQSKAGGKPIDPTDQDDFARPVTLHRRDARQPPPGRAVKTEAPEAPQADEEEVERQAQRKAEREAQRAIDQAKIAPVAKDPNPKRPKKQKEEKTTFNRAPKTETAKKASDLRYEEALPWHLEDAEGKNVWVGNFVDTLSGSNVAFMIDESVFRMIPLEKWYKFTSKPPFQTYDIDEVEAFMSKKVDVGRWVMRDEEKKAGRKDLEATRKMFYGSGPMVKTESATFKAASRSEKLEHDEIDMSGDEFQDDDEAPMFERNDDEDTKDSKDRIRREQLGANLFGEGDEQEVDKELDEQLREEILRQKLGKATKKALIKRDREDIYESDDSEENPWSSSSDDNSSDEEEEEDKKDDEKKDVNKDDKNQSGSGSKGTITPSGKKPEGTKKSKSLKRAGSPALSESSGNESSRKKLKKNVPSATGSRSGTPLVQGGAARRPTAAGSGSDGEATAGEMSDGAAPKRKKLKLVSSSARGTPSASRAGSPNPTQGAASPGSPGTSAVEPSEILDKIPAEGITVNELIKLFNHRLGDRPGQMSKTEWIQLVKKLCDYGPDKRLRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFM5</accession>
    <name>S0EFM5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434725.1">
        <property type="nucleotide sequence ID" value="XM_023582147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFM5"/>
    <dbReference type="GeneID" id="35405986"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12530"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT72647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="397" mass="43631" checksum="419DA205375CEF66" modified="2013-09-18" version="1">MAIESRATQIAAIAYTFVILSSIATCLRVYCRGWIVKAFGADDWLALIAQFMFIVFCSYEITGVRYGTGRHFKDIEPENIPRAMQMWWTCEPTYVLTNMAIKASIAIFLLRICITRTHKIIIWTITGITEIYSLFFFLLFVLQCRPTALFWLRYTSNPPGGSCLDASVVAKAFYAYSAISCLSDWTYSLLPIALVYNLQMSKRTKISVVGILAAGAIASSATIIRFPYLYSLTDIDDFLYSTSDVAIWSTVETGLGITASAVATLRPLLRNFLGHGSSADGQGNSARPWQRTGSNHPTGGYLRSHGQNGEEAFDLHDNAGKRIGVTTIIDHDDKSDANGETGKHGSRSEASDSVAELHGWNSSQSDLADANGQPRAQKGWNVLVKKTVVQTRGSDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFT4</accession>
    <name>S0EFT4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433332.1">
        <property type="nucleotide sequence ID" value="XM_023580579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFT4"/>
    <dbReference type="STRING" id="1279085.S0EFT4"/>
    <dbReference type="GeneID" id="35402167"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08691"/>
    <dbReference type="HOGENOM" id="CLU_035438_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="178"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="342" mass="38341" checksum="A5EE55114E806ACB" modified="2013-09-18" version="1">MGKKRKLSHQNAPNARPKRLPQQNKSDQKKPPNGPAKKGKGKQQHQSDDEPTIPFEPHHRILLVGEGDLSFAASIIQHHGCANVTATVLEKDAEELLSKYPHVEDNITVIRGDAAKTNEADKEDKETPAKEPKAGETSQGSHNEGEDTNGESDSEEDDYYDSDDPNAPPRPKRKLTPNNKLLYNIDATKLPNSLIRARFDRIIFNFPHVGGKSTDVNRQVRHNQSLLVSFFERAIPALATDAAIVITLFEGEPYTLWNVRDLARHAGLQVERSFRFQARAYPGYKHARTLGVVRNSKGEVSESGWRGEERASRSFVFKRKEDIVPVVGKKRRKGDDSSDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGF8</accession>
    <name>S0EGF8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein pth11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_09447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435813.1">
        <property type="nucleotide sequence ID" value="XM_023568650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGF8"/>
    <dbReference type="GeneID" id="35402915"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09447"/>
    <dbReference type="HOGENOM" id="CLU_028200_7_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="50"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT73735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="396" mass="43925" checksum="C8CA62F74243EA90" modified="2013-09-18" version="1">MTDPKVAQAIADGRVPKGVTAAYLNQSKDAPAIVGIILVTCITSIIVLGRLASRAFLIRRFGLDDSLTLVSWVCLVVFVGLCIKLIQLGSGRHFDYIQYVLDMPTIEYTEVLDFGAHIVYTVALLFCRMSGLAFYHRLCAVHDRLRLSIKIVFGILIAGFLPQVFLIIFHCTPVTGLWPYEWQPDFDKYTCLQWGLVYSVNSSVSLVCDLLLFGIPVVMLRVLEMPRKRKIQLGCILLPGISVIGISITRLVFVIEGQWNADMSWAYNPMLAIEVSEIGATLIALSVPGVKPLFDKFILRRDITQGESTGKSRYAQQHSSKGGTALRSLHFRPEHDVLTSRDTSAEGIKTYRSTKNASADNTSENSADGILVQVDFRIKEDTQDSKSGSDAGRSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGN4</accession>
    <name>S0EGN4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436027.1">
        <property type="nucleotide sequence ID" value="XM_023568907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGN4"/>
    <dbReference type="STRING" id="1279085.S0EGN4"/>
    <dbReference type="GeneID" id="35402685"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09216"/>
    <dbReference type="HOGENOM" id="CLU_035263_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="275" mass="31529" checksum="AA03FC39E256E4E1" modified="2013-09-18" version="1">MDNANFPQFQFDTDFSEMADTEQEITLIFTSLLSETQLLTAPEAAAKINDLFPHQPHKDGNKKSPGGFLAAFWDIAFQIAVQLDYRTQQMQKFISLIKALRDLPSTAILEDGRRLWQDLPDLSLFFTERWNQAGITNQATIPPETIQHWINLNGLAAYLTIGNLYGGWYRALESIKLGLENGSRREAQTIIECFAQAAAPWFILSSQQIYHMCRENALQDSSIRGNLWKGRPGFNLERWAFWRSRFIELRNHSLATDELRRVLAEAEAAMERVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH02</accession>
    <name>S0EH02_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436018.1">
        <property type="nucleotide sequence ID" value="XM_023568898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH02"/>
    <dbReference type="STRING" id="1279085.S0EH02"/>
    <dbReference type="GeneID" id="35402694"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09225"/>
    <dbReference type="HOGENOM" id="CLU_071636_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02215">
        <property type="entry name" value="cupin_QDO_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053146">
        <property type="entry name" value="QDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="351" mass="38721" checksum="0C9C49DCFDBAE439" modified="2013-09-18" version="1">MSVPLHTSPPNERTSYMIDQLEGERVSIPGSKGVFRILASSKQTNGGMAVFTSGAVLADAPGFHWHEEAHDVFLVTKGFLKLWSGDKCRIMGPGDFAYIPPHVIHNPLLLGPHTETVGLVAPGDWVDFFRYVGETYNGILVPETDDRDIKSMLMQKMMAAKDRFDVHFKRDYQPPEVGEWLDSENQLAGPGEAYFLRANTGPRWLLGGVMSRPFILASQSGGKFSMSSIESSNVYKKSPLSKWLTFTSIDHCLIVQEGLLRVKIKSGDSSSWSEVREGQTVVIAAGETFTLDFGSKYVRVWTFANGRGIEELVQNAGSPATGFVLPDEVGDWEESKLLDVCKELGVEVADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH63</accession>
    <name>S0EH63_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436444.1">
        <property type="nucleotide sequence ID" value="XM_023569194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH63"/>
    <dbReference type="STRING" id="1279085.S0EH63"/>
    <dbReference type="GeneID" id="35403878"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10413"/>
    <dbReference type="HOGENOM" id="CLU_012494_9_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="45"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="341" mass="37297" checksum="5AA23CF77CF20627" modified="2013-09-18" version="1">MATSLFSSLRGYTYKTIPYKSTPHGDIVLDVVYPEEADDSPTTVLIHIHGGFLIVGDRYSFAPYWLVNAVTTRKWIFASPDYRLVPESTAHASLDDSIDAYKWVRSSLSDAIGRPIGPVLLAGSSAGGYLALTTANAVEHKPDALLLIYGMLDAAGPRYTTPGTNIWGAPPFDTTSVLSQFPRTKENDDRKAISGYPPPENFQQDPRFQVASALHIDALFPDYMTGVEGLSREIASKGIDAIPEEHRRLFPLSFGDLAKIPRTFLLHGVNDSAVTVDCSIVAEKKLREAGVEVEKDFPEDAEHGFDGRIGNVDVEKGEADGIPNIESLRNAIRFLDSSVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHU1</accession>
    <name>S0EHU1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434026.1">
        <property type="nucleotide sequence ID" value="XM_023581311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHU1"/>
    <dbReference type="STRING" id="1279085.S0EHU1"/>
    <dbReference type="GeneID" id="35407512"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14058"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="26"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="124"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="352" mass="39001" checksum="D48D12079B34DDE5" modified="2013-09-18" version="1">MVTHVAVLDDYHGLASSHFARLDPPQYAIQYFPATLRPYNHPDTTQAEKDELVQRLEPFQVLATMRERTPFPKELIDRLPRLKLILNGGRHNKAIDMDACRSRNILVTGNDAKMATVSTLEHIITLILAACRDIAANDTAVKTGKWQTSLVTGVTGKTLGVAGLGRLGSSVARVMNIAFGMKIICWSSNLTQSTADEQAKAQGLPVNGPDGEKTFKSVSREELFSSSDIVSVHLLLSDRTRGLITSEDLSRMKSSAFFINTSRGPLVVENDLLEILKAGRIRGTALDVFNIEPLPANSEWRDTTWGTSGKSRVILTPHIAYVEEQVMNEFYEHQVMELDRWSKGEPLSNIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHV4</accession>
    <name>S0EHV4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436313.1">
        <property type="nucleotide sequence ID" value="XM_023569043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHV4"/>
    <dbReference type="STRING" id="1279085.S0EHV4"/>
    <dbReference type="GeneID" id="35403743"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10278"/>
    <dbReference type="HOGENOM" id="CLU_006033_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050197">
        <property type="entry name" value="Aldolase_class_II_sugar_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789:SF0">
        <property type="entry name" value="3-OXO-TETRONATE 4-PHOSPHATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789">
        <property type="entry name" value="FUCULOSE PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="261" mass="29082" checksum="BAA2F00E7A03CFED" modified="2013-09-18" version="1">MEPAAILQLCYRKFVDGCHILHHNQVLDAYGHLSFRHPIHSDVFIMSRSVAPGVVSSPADLIEYRVDDAEPVEETSLKGYEERRIHSEIYKRHPNIHAVVHSHSEEVVPYAISGVPLKACYHMAAFLGPQGAAVFDIAKHRDPTQEADMLVRNKQTGEALAKTFDNGNNVTLMRGHGFTVVADSIEVAVVWATYTQKNATIQTTTTALQATNRSSTALTYLSDEECSVAQAMSKRTCERPWKLWTREVESCGLYVNSVLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI06</accession>
    <name>S0EI06_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436368.1">
        <property type="nucleotide sequence ID" value="XM_023569107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI06"/>
    <dbReference type="STRING" id="1279085.S0EI06"/>
    <dbReference type="GeneID" id="35403801"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10336"/>
    <dbReference type="HOGENOM" id="CLU_099931_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="178" mass="20105" checksum="AC2031A96BB348E4" modified="2013-09-18" version="1">MPARSLYLAKSGGGANQRSHFALFIPNAEYDRDTISEDFRSLKAIGIRIHVVGEPLMSGFAFEVHRNYNTQAYPDLKRLVFLGKIDDSILHEYPETEFEIRENKPRSLIERIAASVPPPPKGQNICAPIDGVDTKRCQEWTMEVLNMLVEKELIPSESISIAQSERDPPTKGIFGYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EID7</accession>
    <name>S0EID7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435680.1">
        <property type="nucleotide sequence ID" value="XM_023568488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EID7"/>
    <dbReference type="STRING" id="1279085.S0EID7"/>
    <dbReference type="GeneID" id="35403060"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09592"/>
    <dbReference type="HOGENOM" id="CLU_053579_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23387" checksum="A574E41B4D118D3B" modified="2013-09-18" version="1">MPNTPPPALLPPPEGIFRTFEDLMASVQRVAKDQGYGIVKLRASNYRDGKPTRYDLVCDRGGVKYNSTAKKRNPSTRKIDCPFRAKAVCEVQLGNQWRFAIQEGRHNHEPRAPSGTPGQENAPLATSIRSFTNKLDRLNHDMAQGLMRIEQRLDNIEKRMDSLEARAGGGYEPRFQAIEQRLQGMEGPRMDGMGMDDVETRLLASTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIE6</accession>
    <name>S0EIE6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436498.1">
        <property type="nucleotide sequence ID" value="XM_023569258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIE6"/>
    <dbReference type="STRING" id="1279085.S0EIE6"/>
    <dbReference type="GeneID" id="35403935"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10470"/>
    <dbReference type="HOGENOM" id="CLU_066707_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="242" mass="25989" checksum="9D8F0729458706D0" modified="2013-09-18" version="1">MSSPKTVAFFGASTGVGLSALKHSLAAGHNCIALCRIPLKLEAHVSPKAHPNLRIVEGNAHDIKAVSSCLKKDDGSIIDAIVSTIGGKPIIHKMTIDDPNCCRIGITVLLDALAQIRAEGAVGRPHITVFSTTGMSDFGRDYPLLLYPIYAIALKVPHEDKKIMETKLADSGEDFTIVRGSLLVDGDSETPVRVGIEDPKNGIESLEIGYTISREDAGKWLAEKLLVTTRAEYVNKIASITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ47</accession>
    <name>S0EJ47_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435975.1">
        <property type="nucleotide sequence ID" value="XM_023568839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ47"/>
    <dbReference type="GeneID" id="35402745"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09276"/>
    <dbReference type="HOGENOM" id="CLU_095741_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="163" mass="17999" checksum="9691F25D59F11BE7" modified="2013-09-18" version="1">MKSRPSPREYHWGLITTDDIGGPVLHHATNLAGPWKYEERRGQSAIDQTLIVLVKASRVSNVLRATQIIQSVPADGKPSCRTGADFTCRIWVKDALVELHEKGGIFLANDIEVIETEAIAYAERYAADSEQGKGTAVVNGAFAPSPQWPPIERPRKHVFRLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJR7</accession>
    <name>S0EJR7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to TRI15-putative transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437324.1">
        <property type="nucleotide sequence ID" value="XM_023570175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJR7"/>
    <dbReference type="STRING" id="1279085.S0EJR7"/>
    <dbReference type="GeneID" id="35404755"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11293"/>
    <dbReference type="HOGENOM" id="CLU_018787_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="283" mass="31664" checksum="8AD21698AA07FCA5" modified="2013-09-18" version="1">MTSTKPSCSLCDVSFDNSQEHRVHAKSEAHVQALRNRAAASGLIEQPTEDSDTFSHTSNDPENDLSSSDDETGDDTSDSVIPEFDSTKCIICTYSDENFDKNLLHMETAHGLRIPFRDQLIVDLETVIWYLYFLVATYRECIYCGTRRRTVEGIQQHMRDKGHCRVELTDEMQEFYDLEGLKAHGRENAVLVDNESLRLSSGKILSHRDAPVTKPRRTSPQEDNEEKRAPLPSHAASDALTARDKKDAALASQTEKFSPAEEEGIGYSSSGGKEDEVEDGETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKS2</accession>
    <name>S0EKS2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TAD2-tRNA-specific adenosine deaminase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_11611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437629.1">
        <property type="nucleotide sequence ID" value="XM_023570528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKS2"/>
    <dbReference type="STRING" id="1279085.S0EKS2"/>
    <dbReference type="GeneID" id="35405072"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11611"/>
    <dbReference type="HOGENOM" id="CLU_006921_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB-like" evidence="5">
        <location>
            <begin position="44"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="206"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT75583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54831" checksum="E8258BD1461C35A5" modified="2013-09-18" version="1">MESKNPYAFLLQPEQYAPAPVPSLAEWKQLWSVWDLVTTNMMLPDALMEQPIPLRNPLLFYLGHIPTFEDIHLARAKNSKPTEPAYYHQIFERGIDPDVDDPSKCHDHSKLPDVFPCLGDILVYRERVKERITSLYQTERPYTDRGLGRALWVGFEHEGLHAETFLFMTIQSPNILPPPDLPRPDFAKLAKAAASRRLQNPWIKVPQQTFTIGYHDPERNEGPNRFFAWDNEREPYDITVPQIEAQGRPVINGEYAKYLVNVNKLQIPATWSKTHDARSDEDYTTFVARHSIKTVWGPVPLSQALDWPVMASFDEVERYSQWAGARLPTLHELRSIHEYVERCREAPGSKVNHQFHTNPKAIFVDLSETNSGFQNFHPMGITHKGDLCGLGDTGGAAEWTGTLFAPQPGFKAMDIYPGYSDESSDFMDEKHLAVVGGSWALHPRIAGRKSFLNWWQKKYLWPWVTFRLVRDVEDSAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL08</accession>
    <name>S0EL08_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437373.1">
        <property type="nucleotide sequence ID" value="XM_023570233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL08"/>
    <dbReference type="GeneID" id="35404807"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11345"/>
    <dbReference type="HOGENOM" id="CLU_060561_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056143">
        <property type="entry name" value="DUF7726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339:SF1">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24852">
        <property type="entry name" value="DUF7726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7726" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7726" evidence="2">
        <location>
            <begin position="85"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="191" mass="21849" checksum="E8E66A52979A3169" modified="2013-09-18" version="1">MTKAEFCRATGANSNSLNKFLKQKGPFGGSNSAVWRNAYVWFQQREVMGLKMPDAKKRQLKESKKEAPDGTHSKGVALPDINDVPIFDDCDEIRRKINAHMKIPSMTQAQFCRDIYAQFKAPMCKGIQSKQLSDFRKAKSSVFYGAYVYFEKMRIAQKKPVTKHRVEMTFMHPGGIPRDRDDRTTWFIGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELE0</accession>
    <name>S0ELE0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436800.1">
        <property type="nucleotide sequence ID" value="XM_023569609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELE0"/>
    <dbReference type="STRING" id="1279085.S0ELE0"/>
    <dbReference type="GeneID" id="35404250"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10786"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF10">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="275"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="918"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1262" mass="141764" checksum="A31E51FBC974868B" modified="2013-09-18" version="1">MSSLVPVPTAAPLTPAVRLAKVISEFSSALDEKYRPIFKTWQTHSPPSEIDVIRLTEEINRDGSRLHQTSWKPFGTRLLKFLDQIQLLIKPGDILVGGSQNMIASGVWATVRLSLEIATGHLSYFERLSLLLMRLGHATIIQRDRVLLFPHDSDLKALTCEYLIVITEMCKTIIGFEKKGFLAQLATSTCLEKEFKEFETQLAFWSKVINKKLAYLNEASQAQANTSIAAISGSLSSWGESRKRRAEDWRIQVLRQLSPHQDEFESTWRRERRKGSVEWIFDDEQYMNWRSASSSSTLLIHGSLGSGKTVTMANITGKFWPSLSTEPQPGLCAVASFFCQSMDRKTLLPRTLFGSIAHQFLRSLRLPADHPAIRQYSQEYTANDTESIIEFIKAHFPDHCHYYVIMDGLDELSAEDAQEVLRPLADLQTHLQLHICCSVRFDSLIRPMVLELLRTVHSISMSCSRKDREIESYIKGELSRRTLAQRLDEATKEHVQNILVQGAQGMYLWVVLQLNALFPLYGETLTVLGDFARILDRLPTGLFESFEQALGRIKDDKYGSRIFEIVTAAIRPLTKNELRSALNIEPGVPFWDDSTLPLDAEAMVYRCGGGLLYIDEEENTVHYIHHSALRHVLVDSEAECLEDLSKEQNLEGVSSSPQIDSAKNHGLGPAPGKRQHGIFLFTLRQADSTIGFICITALNLEQLDRRISRQRKLVFDKKSLQTISDATTRESLLACFMKTIIQQQRPQQQTPKFDLGRILEVISTAKSSVTVGEAQLFFSYAEAHWLDHTSRPYFNLQEETKFNDLFLKLISENAPGLIFPWDDDKSNNNIALWAHANSHLRLLHHLLCDSKGPECRNVVHTLSKASRSHLSGFSCHKDRLTDVLCRLVDYDFLNVAGVETLLCLGAQPNETYRNGARQGLTPLQVAIERMTENKSYEADVVRALLQGGADAKGSSSGKPPILIAIDAHWGVGYQMLFLSGARVYPVRDYLGHGWSDSMLSALDLAMFRGKDADDMITDLSDCGADIKHYFQEQCWPVSSRSANERPADVLKLSAFSGEGDDWVNIQQIEAQQHHYLSVQDQAQADSRVLKWLLKARCDVNIVSANGMTPLGLAIALLDVRLTRDLLSARANPNARYVSTVSECFQWPLVDAARQGSVEIVRVLLDEGASIHKRSQGKTILRLALEEQRRLNRNLVAIQKALNGFTGSLESVVATDPSILSTITLAIVRPARGSLVLNYRPKLVFHDTWTAIADGVEILSKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELI1</accession>
    <name>S0ELI1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable neutral amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_10830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436840.1">
        <property type="nucleotide sequence ID" value="XM_023569658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELI1"/>
    <dbReference type="STRING" id="1279085.S0ELI1"/>
    <dbReference type="GeneID" id="35404294"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10830"/>
    <dbReference type="HOGENOM" id="CLU_027816_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="44"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT74762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="459" mass="49097" checksum="B40F2FD92EF1A639" modified="2013-09-18" version="1">MATTSPKAKSAKPANMMDDPETADDIQVSQQKQLATQGNAHFHRLGWKRLAVVTIVEAIALGALSLPSAYHTLGMFPGVFLTITLGLVSIFTSYIVGQVKLKFPHVAHYADAGRLLLGRFGYEIFGAALVLELVMVVGSHALTGSIALIDINGGHVCSIVFSAVSAIILLILAIPPSFTEVAILGYIDFVSILAAIGITVIATGIQASDSAGGLSGVEWSAWPKEDLNFAEAFVAVSNIIFAFSFAIGQFSFMDEMHTPTDYMKSIYASCFIQIAIYTLTGALCYAFIGPSVQSPALLSAGPLISKIAFGVALPVIFISGSINSTVALRYLHGRMFKDSILRYVNTPMGWVSWITLVTIFTIIAWVIAEAIPIFSDLLSLASALFVSGFSFWIPGVMWFVLLCEGKWFSKKNMLMSLGSILAFIIGIVTLGAGTYATIKDIIDITSDGSAHAPFTCRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENK1</accession>
    <name>S0ENK1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to zinc-containing long-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_10210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436246.1">
        <property type="nucleotide sequence ID" value="XM_023568966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENK1"/>
    <dbReference type="STRING" id="1279085.S0ENK1"/>
    <dbReference type="GeneID" id="35403675"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10210"/>
    <dbReference type="HOGENOM" id="CLU_026673_14_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF2">
        <property type="entry name" value="GROES-LIKE ZINC-BINDING ALCOHOL DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="13"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT74168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="372" mass="40333" checksum="2F80BAE17EA8B054" modified="2013-09-18" version="1">MNTKFIAAYEPQGTTPDLRLVNGSVRAARSSELLIRVVATGICHTDLIFATWPANQIPYPKVLGHEGAGVVVEAGPGVTKARPGDFVLLSFHSCQNCHDCKEDHPSFCSKFVEINYGGEDATYTAEGNDLRGNFFGQSSFAELAVVKETSVVNVTNIIKTEEELKLFAPMGCGFQTGAATVENVARANEKDRVAVIGLGGVGLVSIMTAKMQACETIIGIDRVPERLDLAKALGATHVINTSDENIDMQEEIKKVTDGRGSSITIDTTGNMGLIKAGLEATSNRGQLIFIGVPPLDAMMDLHLVTFMQTGKVIRGTIEGDAIPDEYLPRMVQWYREGKLPIDKLISLYKPEDFETALIDMKNGKTVKPVIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENS0</accession>
    <name>S0ENS0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437865.1">
        <property type="nucleotide sequence ID" value="XM_023570805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENS0"/>
    <dbReference type="STRING" id="1279085.S0ENS0"/>
    <dbReference type="GeneID" id="35405320"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11859"/>
    <dbReference type="HOGENOM" id="CLU_010595_7_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="351" mass="39772" checksum="ABC1AC0E077F7820" modified="2013-09-18" version="1">MSSPKSQKSRSPTKSPPGPQSPAAVGQVAEEQAAIEVDDDSDSSYSKSTGITDTESLRSSIMAFKWENGRRYHAYQDGSYWAPNDDRQQEAEDLMHEVYRIILGNSLYEAPIGDNPQKVLDIGCGTGIWAIEFADEHPSADVLGVDLSPIQPSFVPPNCRFEVDDITNEWTYPEDTFDFIHARSMIGCLPDWTEFYRKAFKHTKPGGWVESVELWGNSKCDDDTLKPESPLHKWVEVFKKIESLTGKSFFWDDKMQQSISDAGFINVSGRRIKVPIGTWPKDKTLKQWGAWNRHFLLQGLEGFSIRGLTEMLGWKYEDAQLFLADMRKELTNPALHAYLDVTVFYGQKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPD8</accession>
    <name>S0EPD8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437021.1">
        <property type="nucleotide sequence ID" value="XM_023569867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPD8"/>
    <dbReference type="GeneID" id="35404481"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11017"/>
    <dbReference type="HOGENOM" id="CLU_112091_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="152" mass="17455" checksum="C1E08F7125D1D3F4" modified="2013-09-18" version="1">MAITDKIHPIYSLWFLWVDPILTLVGMYGNFIDHDLAMQAFFTNYPPTDHFRCFIYQIGGMGTSYLIILVVLLRYTHDIFIWKTVQLAILPADFTMLTAIYIGMRISGNLALADWRWEDWFSIVVTGICTVLRIAFVLGVGVKDTRGRAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHX8</accession>
    <name>S0DHX8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PARP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423980.1">
        <property type="nucleotide sequence ID" value="XM_023576872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHX8"/>
    <dbReference type="GeneID" id="35395088"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01603"/>
    <dbReference type="HOGENOM" id="CLU_529054_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="57025" checksum="03AED93EDE4F93FF" modified="2013-09-18" version="1">MGEYTVIEGNTPESVTDWSNHQNNSGSDVFYFSFAELAMQVVLSADHQTMISSQIIDTYRTFSRKSIDPLREEVRSIMRTALGDDSCHVRKFDIQIAILQMLEAIHEFELARQSSKPEKYEKGYAADEVSDWNEVINNPFGLDVSTIQDTAYSILHKTPEELTAGIPKEWRVIHMESVLRHDLVRRFWSYQESLETDLRSCGTSLRDRIPPHSKLTGQVRAQLNHETIIQDMTSPRVTFHGTPLQSVGSIVRHGFKMPGKLVEGKVVASPRSGIVFDRGIYSSQEAFYAISYARGQREMTPVGMLPSMRLFVCATIMGRTYTGSDGRHGPLIEGHDSHFDGGFEYIVHNERAMIPCYVIHLDLGSEAAKQALKDVQANPEEFYNLTKTKKLPEAKSTAPGDIQREKEARKAAALKWFPYGFGPATGTTFVIEEVGEISDDEEEYGDWQADKHGYSNAYIEKNTVWDDEGWEYYDENGNLVKGKRRLMDQYQHATRAHKNKKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIB5</accession>
    <name>S0DIB5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to Protein esc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424195.1">
        <property type="nucleotide sequence ID" value="XM_023579539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIB5"/>
    <dbReference type="STRING" id="1279085.S0DIB5"/>
    <dbReference type="GeneID" id="35394850"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01365"/>
    <dbReference type="HOGENOM" id="CLU_017046_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF23">
        <property type="entry name" value="ZF-C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="336"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="492" mass="53689" checksum="5D3CD0A0596076D1" modified="2013-09-18" version="1">MDVHNQPRLPPPKPVGLNNILNNDNAPVSIVNGPPHMRDSGFYSNADASSKHTSAASFNVNGLSPSGSGYQSSSHEKTPSPIASNMIPNGLTSPSTTNMSVAAMVSPSTPSSLDPCRDRPTSIESNGLGPNPGPTMGDTLAPGMAAMRRESVDSRINQNFGDLRLGGSPYASHNHSTTSIQNTLHNQRNPHHLSVHRISNGYQPSADRNPEGKTVKTAPAITGPATGHIARAAEPTKGQAWAFPEEEIQRVGGAPTYTDSRRSSITESIASSQFTTESRLPPGQMRLNESEYSRMSNASDFPPVHHHSMQHKQLSDLQAEEGNGSTGSQPYSRTPELRVSHKLAERKRRTEMKELFDQLRDLMPQERGSKASKWEILTKAIAEHQKQQDIIRALQDHYKSNTAENELLRRDVHALRMENQQLRSELNSSSSRPPLSSAATPAPQAGTYQTDPYPNPNRPELPPLRSLRNSIPNGPDSMTGVQYDSPRTNGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIH4</accession>
    <name>S0DIH4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_01236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424310.1">
        <property type="nucleotide sequence ID" value="XM_023580972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIH4"/>
    <dbReference type="STRING" id="1279085.S0DIH4"/>
    <dbReference type="GeneID" id="35394721"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01236"/>
    <dbReference type="HOGENOM" id="CLU_046496_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="52"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="285" mass="31782" checksum="6A2A9F3445DCCB9A" modified="2013-09-18" version="1">MDLWEGLKQSYLDDFDVMLSGYIPGAAAVETVGKIGRELKEKSSKAPGKFFWALDPVMGDNGKIYVSEEVVPAYKRLIHDADLILPNQFEAELLSEVKIHDMDSLRKAIQVLHDKYKIPHVVITSVNLEAPDHPPSHLSVVGSTMTSTGKARFFKIVFPSIDCYFSGTGDMFGALMVIRMREAVFNADERLRHTASWLSGDSVSAVELPLARAAEKVLGSMHEVLSKTCEGMKRVVERTTDDMKDKDRIDETKAHLVKSKAAELQLVRNLDCLRSPTTRYLAKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIS0</accession>
    <name>S0DIS0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424241.1">
        <property type="nucleotide sequence ID" value="XM_023580094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIS0"/>
    <dbReference type="STRING" id="1279085.S0DIS0"/>
    <dbReference type="GeneID" id="35394800"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01315"/>
    <dbReference type="HOGENOM" id="CLU_005049_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF16">
        <property type="entry name" value="DUF2235 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="31"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="586" mass="64637" checksum="022E013655CBD8E9" modified="2013-09-18" version="1">MPSQPQPKQVFLPLEDGSHHEAKEDAFAAPKRIIICCDGTWQSSVSGLKNIPSNVTRLARSIARSGKDKDEKVWQQVVYYDAGIGTGDLGQAEANRQGGAGIGFVGNVIEAYNFIVLNYNIGDEIFCFGFSRGAYTARAVAGLVTDIGVVCPKDLQDFPDLYALYQKNPDGYHFRKSQAYMEWVNGVPSKKEANGGSQIQSQWDSPPHHDAPESSRFVKVVGVFDTVGSLGIPDLPWTRFNLKFLEKAVGIADPGFHNIHLSPYIQHAYHALALDEHRAPFSPSLWHFPANKDHDPPKPAKDVEQLWSDWEKMYKNSSATKKQLQDAWGAVVDGEMYEHLQGNKSELLQVWFPGVHINIGGGNDDLLTEKKSDLEQIALISFAWMCEQVAPYLQFVEDGSLGELGKSAVQDRYNLLKPLLTNIQTGDEKDYGPGPLSSRIAASLDRTGIKKADVRKIPEETVSGWATGPIVDSFTGAMIAGGSVDRVPGNYTKDDKGREIGDTYEMIHPCVKYRMSKIPSYKPKALRGFERTADGGKGFVWTKGNVKIPEFVIKTGDAFSRHVAEQDRSAGGNARDFLKSIDTVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJG3</accession>
    <name>S0DJG3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="16">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_00751</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="16"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424755.1">
        <property type="nucleotide sequence ID" value="XM_023571574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJG3"/>
    <dbReference type="STRING" id="1279085.S0DJG3"/>
    <dbReference type="GeneID" id="35394236"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00751"/>
    <dbReference type="HOGENOM" id="CLU_003827_9_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-0274">FAD</keyword>
    <keyword evidence="4 15 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="81"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT62674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="332" mass="36311" checksum="00B70F57A7F9D4EE" modified="2013-09-18" version="1">MFARSAFRAAQPLRSVRRYATEAGGAGGSNAFLYAAGAAAFGGAGYWYFSKGGAPSAAAAAADVKQAVGIEPKKAFTGGDQGFVSLKLSDVELVNHNTKRLRFELPEPDQVSGLHVASAILTKYKGPNDEKATLRPYTPISDESEKGFIDLLVKKYPDGPMSTHLHNLVPGQRLDIKGPLPKYPWEENKHEHIALIAGGTGITPMYQLARAIFNNPNDKTKVTLVFGNVSEQDILLKKEFEHLENTFPQRFRAFYVLDNPPKEWVGNSGYISKELLKTVLPEPKNENIKLFVCGPPGLMNAISGNKVSPKNQGELTGALKELGYKEDQVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJK4</accession>
    <name>S0DJK4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423548.1">
        <property type="nucleotide sequence ID" value="XM_023575117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJK4"/>
    <dbReference type="STRING" id="1279085.S0DJK4"/>
    <dbReference type="GeneID" id="35395539"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02056"/>
    <dbReference type="HOGENOM" id="CLU_980200_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="284" mass="31247" checksum="48F3066CA9D57B8D" modified="2013-09-18" version="1">MAAEAVGLAATVITIADAAYKSSKRLYELIDGFRTASKTLSDLHTDLSSLEQLLQSLKDALGKADDESLSDEMRKCLQNLKPCMVACCEVCDDFSAKVMQITSHSTEDHVSWRDKIRLQFEEKGIQAFQFRLAAHKTTINIVLGLVNLLYLTDKIEANQILNRSTSSDQNRQAYKNLETNIITALAEHNRVVMEALHEHAVALQQCLRVCYSVVDAAPASTSDTVHRMEGYDSAKQLVAGDIGDAVLRSRPVTVGIASAHQQAQQALFQNVGADSIDGVMKFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJU0</accession>
    <name>S0DJU0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424925.1">
        <property type="nucleotide sequence ID" value="XM_023573155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJU0"/>
    <dbReference type="GeneID" id="35394047"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00562"/>
    <dbReference type="HOGENOM" id="CLU_030204_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024325">
        <property type="entry name" value="DUF3835"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039553">
        <property type="entry name" value="Prefoldin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12927">
        <property type="entry name" value="DUF3835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13758">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3835" evidence="2">
        <location>
            <begin position="501"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="580" mass="65298" checksum="8DDA8171827B35AC" modified="2013-09-18" version="1">MAGVSDFDKQQRQLEDDLSKLQNALKHWQTWHVEYEMLKEEVEAVCKDGETELKTIHAGFEGALLKDRELDEIFGERTHRSGEQILNILDRRIDYVTTNITSLQKQISAAETKLDESQADFTEDDGLPITEIIEQLDDDDNVISYKLNQPDTALPKIQDALQKAGIDDLEDDNSASKAESSKQKEAEHSQERPSQHTELESTTLAPSATKGVVFAAETKMQDGPKPQVSRNAKRVEEIMNHAKEQEKISNEQAYIPEDEDEEDADLRRQMLEYSGEVGAVVAELQLEEGDSDDYEYEYSDEGFEDDDDDQEDKYGRYTGRVVTDDYRQRMLELEKKLGIKSRFTEQPEDRDGDASSDDEEGIGRIVVKPASATTTLSSSASKPAPTKSNIKEKQPEQPNGKKGVRFASNLDIAPENEPTVLPVREAPVKEKEPIVEPLSDKIVERSSTAKAPDTSEIKSTRKPSRFKKARDTVPPGPLDVPAKFLDQDRPTAPTGPEGTTLADTLVERESIRAAPHPPDEFDDELIYQEVADEHHKLRKKFIQREGGFLKEDESPIQPLEEQDGGREPVSRFKAARLSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJZ0</accession>
    <name>S0DJZ0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424781.1">
        <property type="nucleotide sequence ID" value="XM_023571907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJZ0"/>
    <dbReference type="STRING" id="1279085.S0DJZ0"/>
    <dbReference type="GeneID" id="35394206"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00721"/>
    <dbReference type="HOGENOM" id="CLU_076902_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="106" mass="12197" checksum="6234FC8A4BFC9382" modified="2013-09-18" version="1">MDTEKAREYLSSILNKNLRVYTSDGRLFWGALKCTDPDKNIVLAHTYEYRQPSSREREKAAEKADGETVKVDMTSRYLGLVVIPGEHIAKMEVEEFASQMRNQNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK86</accession>
    <name>S0DK86_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425070.1">
        <property type="nucleotide sequence ID" value="XM_023573331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK86"/>
    <dbReference type="STRING" id="1279085.S0DK86"/>
    <dbReference type="GeneID" id="35393889"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00404"/>
    <dbReference type="HOGENOM" id="CLU_024198_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="596" mass="66413" checksum="A8A41441B4CA0AB0" modified="2013-09-18" version="1">MSDHSSPDAPQSPRDLSYDPDRYDWEDFARAGDDWEDQDRHICLHDQCDLCLLDMAPDDLAIAVTCETHLRPSYCTKLFRFPAGKEEFQPDGERWILCWDAKCNQSSEVVTMHASCYQLFFQHYTHDNPLKDNSLVSVSPSIAESLGIPQLAQLPPSLVQDIRSMSPDSQVWAYLAIKDRAEGISSAAGRDDLSCMLDKVESWTRDEGAPVMSDSFAGDWSFRVSIDRRGIRNIERIFGISSYAGWRSESLAFALIPPDQAMRSCVDFRLGAARLDLWGGRSVLWDTPSPPLGGKVSWFTASGPSQLSNVRLRMLDLRSTRGLTFFYAGSSLRAIHSHTPRFPTALTTYARLPEHDRKHVVWAHVPISPNDRVIGLGIRTSGTKGGFASPSVLIRTELAGDIVIGPQPKPVHHDLPLVLIKDYSCDIIPEFFAYSLPDINGEYMLLAVAGESCEPNAEGIIFGYEHGAQGAVGQCRIGIDNVTTYINPTGICYSDMMRAHCCDGDDDCSNEEHEPSEEMECTAHQGSSKVECYSGADGHHHNDSDEHVVCVPIEGYLDCHWDDRWTRLDVKEHAPEAVEAIMQVDMNGRNPRVFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKF1</accession>
    <name>S0DKF1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425130.1">
        <property type="nucleotide sequence ID" value="XM_023573401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKF1"/>
    <dbReference type="GeneID" id="35393826"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00341"/>
    <dbReference type="HOGENOM" id="CLU_1180306_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="235" mass="27544" checksum="E334E2D4628244E7" modified="2013-09-18" version="1">MDLENEDRWYIDSDAETDSTETAYFKENSGFSPSCGLCRFNFSIDDSVVVFKEKCEPWTTTYSEPEIWWTIHYSKHTFHAECVDLAPDLMSDQRLDPDIYNATILEPLQEGRHPLPSIQTRRLKWLKKTFSEQLFQTIKNRLPLEVCENIARYCLQERAVQVVRHHWLRKDRPKPGRISVAIREGKPLWAQYVEFEGIRYVKSLSYQSLGGDESQILSNPDSDCNVNIFIAHNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLX0</accession>
    <name>S0DLX0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425517.1">
        <property type="nucleotide sequence ID" value="XM_023570285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLX0"/>
    <dbReference type="STRING" id="1279085.S0DLX0"/>
    <dbReference type="GeneID" id="35394352"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00867"/>
    <dbReference type="HOGENOM" id="CLU_123956_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7 10" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT63436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="123" mass="13311" checksum="26AE7A1543495833" modified="2013-09-18" version="1">MKLVRFLMKCANETVTIELKNGTIVHGTISSVSPQMNTALRTVKMTIKGQDPISLETMNIRGSTIRYFILPDSLPLDTLLIDDAPKPKNKARKEAERGGRGGRGRGGPRGRGRGGGRGRGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLY2</accession>
    <name>S0DLY2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NAT10</name>
        <name evidence="17" type="ORF">FFUJ_00504</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLY2"/>
    <dbReference type="STRING" id="1279085.S0DLY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00504"/>
    <dbReference type="HOGENOM" id="CLU_004652_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="13">
        <location>
            <begin position="282"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="537"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="16">
        <location>
            <begin position="775"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="638"/>
            <end position="640"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="645"/>
            <end position="651"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT63455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1066" mass="119344" checksum="D605A2FF80DEAAFA" modified="2013-09-18" version="1">MQRKAVDSRIPALIQNGLQEKKRSFFVVVGDRSKDVIVRLHYIMSQFDIKQNKSVLWAYKNKLLGFTSHRKKREQKIKKEIKRGIREANTEDPFELFVSLHNIRYTYYKETDKILGQTFGMCILQDFEAITPNILARTIETVEGGGLVVLLLKGMNSLKQLYSLSMDVHSRYRTEAHDDVVARFNERFILSLGSCNSCLVIDDEMNVLPISGGKGVKKLPPPDLDNPKTESQIELEAMKEQNEGRQPVGPLISLAKTVDQAKALITFTDAIAEKTLRSTVTLTAARGRGKSAAMGVAVAAAVAYGYSNIFITSPSPENLKTLFEFVFKGFDELGYADHADYSIIQSTNPDFNKAIVRVNIHRQHRQTIQYIRPQDAHVLGQAELVVIDEAAAIPLPLVKKLMGPYLVFMASTINGYEGTGRSLSLKLIKQLRDQSRTATTAGEGMEITDRSTGKTSKTEEFQAGRKLREITLSEPIRYAQGDAVEKWLNTVLCLDATLPKAKSNINGCPDPTQCQLLNVNRDTLFSFHPVSEKFLQQMVALYVASHYKNSPDDLQLMSDAPAHELFVLVPPVSEDSSRLPEPLCVIQVSLEGKISRQSVLNSLSRGQRPSGDLIPWLVSQQFQDEEFASLSGARVVRIATNPEYVSMGYGSKALELLVDYYEGRFANLSEDEDQIMEETMTRVTDAELANANLLDDDIKVRDINKMPPLFAKLSEKKPERLDYVGVSYGLTQPLHKFWKKASFAPVYLRQTANDLTGEHTCVMLRPLENSEDRSWLGAFSRDFQKRFLSLLSYQFRTFTPITALSIDEAAKLGAQLDSVEVQPLTKADLDIYMSPFDLKRLESYANNMLDYHVVLDLVPTIAQLYFTGRIKGDVTLSGVQQAVMLALGLQRKDIDVVAQEINMSTSQALAMFIKMMRKVTKHFAGLVSEAVGAELPKVERLGVSRENASGAHDDEIVDERYIPLATTLDDELEEGGDEAMRELKKKQRELIDSLPLDQYEIEEDTPAWEEAEKQVLSATKQGKSNPVVSVKSAKQKRKAGGQTAAEVYEEAFGEKKKKSKRVKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM03</accession>
    <name>S0DM03_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to DUF1446 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425730.1">
        <property type="nucleotide sequence ID" value="XM_023571423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM03"/>
    <dbReference type="GeneID" id="35398681"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05200"/>
    <dbReference type="HOGENOM" id="CLU_012617_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF1">
        <property type="entry name" value="DUF1446 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="489"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="603" mass="66702" checksum="5331CCDC1B5394C4" modified="2013-09-18" version="1">MLDRPPIRIGNVSGATGDHPHAMSRMVRSGNVHVITGDWLSEMNIAWNAITKQEVDPKLGYENGFYEQLDECLDDIMQRDIRVVTNAGALNTDALYDKVRALCEKRGYGDCVVAKVLGDDVSDVVGRRDVQITHLDHPEQTLESWGFTPCCATAYIGCWGIVQALRSGARIVICGRCTDASPVMGAAAWYHGWREDQYEELAGSLLAAHLIECGPYVVGANFSGFKDFLPELVDIAFPIAEIDPRGRCTIGRTAEGGGRVTKETVTAQLLYELQGHLYLNPDVVADLSGVHVEQESENRVSVSGVKGLPPPPTAKVMIAAKGGFQAEATFYINGLDVYEKAAMMKNQLAHMFKDSNFSRLSIELYGTPAENPTSQQAGTVSLRVFAQARRKEDIDAPKFKVPIYALRMQSYPGYHMNLDFRTMVPKPFMEMFPALMPVSAIEHRVEMSTGASHRIEPPAKTAKYPIVRPSTETHGPLDMLTFGPTEWAPLGSVVHARSGDKGDNSNVGFFVRNDDEYAWLRNVLTVSKLKQLFGDDWFKGDPERRVERVEFPGINAVHFRVLDNLNGGIASSDRIDGLGKGIGEYLRSRYVDVPKAYLERGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM14</accession>
    <name>S0DM14_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423644.1">
        <property type="nucleotide sequence ID" value="XM_023571529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM14"/>
    <dbReference type="GeneID" id="35395439"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01956"/>
    <dbReference type="HOGENOM" id="CLU_1959649_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494965" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13175" checksum="C7E8FA3634ABDDA4" modified="2013-09-18" version="1">MFSLIPLLSLLVVGSHANPFLDARSVASVELPAKLSAINFDPANKDGVTFHIAAAGVDTQCYPPTKDTVAAGRIYKCGENAAVTFSYTGEDGKLSVWLSNENGSFAGSTLVSGPVSGEVAIDLASLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM16</accession>
    <name>S0DM16_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="14">TC-AMP synthase</shortName>
            <ecNumber evidence="3 14">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 14">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_01025</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 14"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424508.1">
        <property type="nucleotide sequence ID" value="XM_023568530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM16"/>
    <dbReference type="STRING" id="1279085.S0DM16"/>
    <dbReference type="GeneID" id="35394510"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01025"/>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="16"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT62427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="409" mass="44003" checksum="CC763EA9B55C4A0A" modified="2013-09-18" version="1">METRIVKVPSKGSLGQFRPGDGLARLNHWEDTPVAFPTETVYGLGADATRTPSVKGIYSAKGRPSDNPLISHVCDLEMLRQYIGHTDETDPIPQRYRALIERFWPGPLTILLPNPVPSKLAPEVTAGLKTFGVRMPSSTLALSLIKLAGVPLAAPSANASTKPSPTAAQHVMDDLNGKIELILDGGHCQVGVESTVVDGLCNPPVVLRPGGIGIDELRSCPGWENVSIAYKDKSEEGKAAPRAPGMKYKHYSPKATVVLYESSFAEGVNGIASFDLKAANETVNGHASNDERKGRVVGVIRTQRWKSGAGLRCTSFQHLADVQGADEDDSPFQVYEGDLLDEKEQPIGNILDIDLGRGTEGIARGLFAALREFDRRGADTIFVDGIDDRSDIAAAVMNRLRKAASETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMF6</accession>
    <name>S0DMF6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to heterokaryon incompatibility protein het-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423829.1">
        <property type="nucleotide sequence ID" value="XM_023575051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMF6"/>
    <dbReference type="STRING" id="1279085.S0DMF6"/>
    <dbReference type="GeneID" id="35395251"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01767"/>
    <dbReference type="HOGENOM" id="CLU_004184_7_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="142"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="694" mass="79039" checksum="9EBEEA87CD10E1FD" modified="2013-09-18" version="1">MSIKSTSPVRLLSRRALRKRPHAGDLMIYKETKSTPSVEVSRKRSKRTGPSSFGLHDISHHQRSTSHSRTLFRTKSHCSTVSLLSSMAGVVQPSEPTAPESYAYTPFTNNFTIRILTLEPGTGNDPLVGHLGFENLDLNPQYEAISYCWGTGGRSSEIICDGKPLPLTESIEGALRRMRHATTQRRLWADQVCINQDDIAERSQQVSLMNAIYKGAKHVLVWLGEDKVGHGQAAMEMVHYLHGVFNDGELHNEFKRAHSEDLLSQDRKPWVPFSNLSRLPWFNRIWIVQEIGTAAPATLYWGDAEIDWEVLSSVAGILNTTYHFLRSRFAVFTPNIRYLYQRFVEPEEAYDVNHNRAAFIYELHRARHLLSKDPRDHVYAFLGHFSIHTGSSSLAELVADYSRSIEEIYYDVAVRELSGCESLLLLSACHAIPVTYKKRIMERGDLPTWVPDWRVVPLHLMGTPVTPHRSSGEYRPQLCINEETRALHIYGVRLDRIRRPSWIFWNNAFHFRRNNPLRLPIEALWRDICGRNQPFNLRQRYRNGDSAFFALVQTLTNACIGADRSRPYESIPKEEWLANGAAYLIRALDKPGAVSPEIQELAQTGDGFKWSHEATLVTRYRGFAITSGGWFVVGPDIMQAGDVVVVLYGGRTPFLLRRKDDGTWILVGECYVHGMMNGEIFDLDGVEEEEFVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMH4</accession>
    <name>S0DMH4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to GTP-binding protein rab2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423849.1">
        <property type="nucleotide sequence ID" value="XM_023575295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMH4"/>
    <dbReference type="STRING" id="1279085.S0DMH4"/>
    <dbReference type="GeneID" id="35395230"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01745"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="254" mass="27763" checksum="B0A75FDE9110BFCE" modified="2013-09-18" version="1">MSTTPWDYIAKLVCIGDSGCGKSSLTIRLCEGRFSPHHDVTIGVEFGSRIVPVGPPHSKIGAANSSDPDNQDQEADGLPEPPRDDSNTPQKHMKLSLWDTAGQETYKSVTRSYFRGASGALLVFDLSRKQTFQHVTDWLNDLRQIAEPDIVVILVGNKADLTQQEDNKREVTREEAEEWAKRNGVMEYVETSAKSGENVEKAFMRVAERIYNNIQAGKYDLNDRRSGVKGAGAGGTRQVKLSGDASKSAGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMN0</accession>
    <name>S0DMN0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424698.1">
        <property type="nucleotide sequence ID" value="XM_023570874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMN0"/>
    <dbReference type="STRING" id="1279085.S0DMN0"/>
    <dbReference type="GeneID" id="35394299"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00814"/>
    <dbReference type="HOGENOM" id="CLU_045564_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="316" mass="34582" checksum="C0DEB9E0B598B0F8" modified="2013-09-18" version="1">MSTKTETMASSSFRLGHHPSTHLAPPPDYYTTQAVELSRLSPAMSSTTSLPEYTTQYSIENGDSASSSSTSGFCPTKQLQIEAPGFALIRLPLPPQPDPIYVFNVAATGELDGAEYVSIRPTRNSGSCFLARANDPTQTALCTTTYRFGPGKPPKIRFVGDGSQNGQTEEIEVSCKGVLTRSTIMRTHLGTFEWRYSSRAERRSAKSSVGEEVDCLLILDQVMKVAVPGGKQEERRRKVGQFVRSDGLRTQGSRRSSAGNGGRLMLDLREWLDRKNEASEMEILAVVSCVSMMKKEVDRRRMHQTMAIMGGASGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN22</accession>
    <name>S0DN22_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425921.1">
        <property type="nucleotide sequence ID" value="XM_023571649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN22"/>
    <dbReference type="STRING" id="1279085.S0DN22"/>
    <dbReference type="GeneID" id="35398479"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04998"/>
    <dbReference type="HOGENOM" id="CLU_009124_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="834" mass="91529" checksum="B17A1A4D2D277ED9" modified="2013-09-18" version="1">MSFRDSFMTHSGTLEVLQSHHAPARRSRPPDIDTMAAEENRVPLKAERASKRESRLGLRSLFSRSKTHLASPETPSSFGSRTSLPETNPYFPAQPDAVFDDMPSSPHSPRPLATMFETQQSPPAQPRPVGLVRAQGSGKPGRGPLSTWHPPPLFKAFPQAVKHMTLPATSLAPEAILRMHERRASALRDENAETPDAEGAPTEKAKVKKKHRRNTSGHFPKFEWTNKIYVLVTSGYLLQYAAEGPFDRLPERILHLSKDSAAFASDVIPGRHWVVQVSAAAESDGTTSSDSRSLFSRWNFRATERRHVSNFLMVFETAEDMEGWISTLRREIEALGGKKTLTETGKPKAEDEVAPLREKPSQRTLVVRDPNRLSRIASSSSQSPQSPDSFLPPQNLQWQSQTQSNRSVTNVAEPEPTADQPLDDISTTNSFVSHDGRQLENLRENSNRLSFISSGQRTVVTSAGSSPASSPTVDTFPAPVEHKSSLEEAKLSPEPKPRPNAAAILDRRQSMQVLTPFVELQGGPINLRPQSSYGSGAADLKAPTPNFSVPNSSNRRYSYAKTMAQEFGMAPSSGPLEVRSLGRRAPPTTLPIARPLSMVADQPSPMEDIHERPVTRHGDETQSTIPVEDDLPSLPNIPTSYEMTPRRSSLVPIEEPNVEISRPGSSRRQSDMRQWRKSENPNAMGRSVPSSTRPSLEQRTRSRSFLGGAEEAARRRASLDTYSDARSDSMSAKGRSQRRASIQSVMSDRASQYSASGDLPPPMSPESLPLPAPPPTVPLPPIPASASNPLLRPDMNGKSLFIRRSMPHLGEVPPPVPPPTCALPPLPPKLQVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN31</accession>
    <name>S0DN31_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_04830</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426075.1">
        <property type="nucleotide sequence ID" value="XM_023571836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN31"/>
    <dbReference type="GeneID" id="35398311"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04830"/>
    <dbReference type="HOGENOM" id="CLU_1046024_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="13" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="259"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT63994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="313" mass="34133" checksum="0DEF76642F5C5E1F" modified="2013-09-18" version="1">MANKNAKSLYEAIPECISGCFDISVANTGCANNDYDCWCYKPNHQTIVDTLEQCLSNKERKTKKKCTEDDEFEYENSYWKICEQYWEPYGTATEPTSFPTAVSSKTSAASTTLKVSTIVATTALSEETAAAEESTWTSLAPTETGDSEQAQASDEADTVEPTHSGLSPGGKAGVGVGVAIGVILIGVAVFLWLRERKRRRSVEEQLRIVEIEKANASQEVYYVSKGLYEMEGDRPHAEELRGCMRTPELGAAEMINSSSVTHVGPVSPSDDDRDSSFSTRSHSWPISPESPSRQESRGLGEITDNNTAKPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN67</accession>
    <name>S0DN67_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_01494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424079.1">
        <property type="nucleotide sequence ID" value="XM_023578083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN67"/>
    <dbReference type="STRING" id="1279085.S0DN67"/>
    <dbReference type="GeneID" id="35394979"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01494"/>
    <dbReference type="HOGENOM" id="CLU_056436_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001075">
        <property type="entry name" value="Zinc finger, C2H2-type/integrase, DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT61998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="299" mass="32960" checksum="A5A73430D8E7C52F" modified="2013-09-18" version="1">MTMHAINAAGRRVSLLNDESASQQQQQQPTQRPPLSFHSHSSYAFTQSYPTPGSTSSSPNTPELLRSDSYDSQMSNDPLSPLTPNVDYYPRQQVMYTISQDYNMEAKHAQYADSTRSASYDAEMVSQPRSSPMPERPGKRYPCRYRDTHGCEKTFTTSGHASRHSKIHTAEKAVQCTFAGCQKKFTRADNMKQHLETHFKDKSRSSTSQRSHRTSLADARRNSTSGRPSASRTSSSRSRRDADPYPLPTPPLASPSVNSGSWDLGGRNLPILNRPVAGRTPSGLDALAMAVACQEGSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DND0</accession>
    <name>S0DND0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to vegetatible incompatibility protein het-e-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424124.1">
        <property type="nucleotide sequence ID" value="XM_023578617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DND0"/>
    <dbReference type="STRING" id="1279085.S0DND0"/>
    <dbReference type="GeneID" id="35394931"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01446"/>
    <dbReference type="HOGENOM" id="CLU_010671_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF12">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="625"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="805" mass="89162" checksum="C620C222D7B7D1E9" modified="2013-09-18" version="1">MRRSALHMPKSRLRNNPPLPANTTASIAGSSVDVVGALLRDEGFQAEHRQLADSSTTSSASYNSFNARPPSLPHGSHPQYNPTLLPSTAESYNIPEFTADSPMTDAFPTEDNTISTTKTPTFAIVTDGSSTAIATEFSDQNNYDQFSSNAYIETYNSESESPDSESDPDQEHQDGIDLDLDTSTHPPFLGDYWTPPTYLDLDSDHIPSYHNVDYDIDMSDSEGGAPLDDAFDELGHFTDDQSILSEEDNDESPPINHSTNYISQSAFHPPTIVDDNDLIMNSVPPPAPWGDVLTEDAAALEDNAPSVPSEALGQPLLSNPNPTMIGSHNLGLVDFLRHWAYQARASSCPSPSRVHAPYPEDIRRQANAHIRDVQYKDLQGDDYDIQGLDWASMNTTREYARQIRCATFHNYVNKNGSDRWSPHMDDAAISATQNFMRFKRFLIRQDVYLAHFQLRSVLACPSISQAYYPGRRGINRINPVTGKVELVLNNSHIHGLGALISTLDANHGAMFAGTFNGEYYLKSLGSEDKKDFAEGVITTNTGGITNHVQIYQPRRSSGPVAAIASNDEGFRLLDLSTQKFLMQSKYRFALNCSRMSPDGRLRVMVGDDFKVLITDADTGEIQQELSGHRDYGFACDWSDDGRTVATGFQDMGVKVWDARRWCDTRGVSTPLCTIRSDMAGVRNLRFSPVGSGERVLVAAEEADIVNIINAQTFNKKQTVDLFGEIGGIAFANGGHELNILASDRHRGGLLQLERCGRTAEPYFFSSWKRYVDGDTADWRHKPDEFTRSGECYRRAPASRDALPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNJ4</accession>
    <name>S0DNJ4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_04824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426081.1">
        <property type="nucleotide sequence ID" value="XM_023571843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNJ4"/>
    <dbReference type="STRING" id="1279085.S0DNJ4"/>
    <dbReference type="GeneID" id="35398305"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04824"/>
    <dbReference type="HOGENOM" id="CLU_001771_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000074">
        <property type="entry name" value="P-type cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056236">
        <property type="entry name" value="HMA_PCA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF4">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24534">
        <property type="entry name" value="HMA_PCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="831"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="869"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1179"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1206"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="431"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT64000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1230" mass="130480" checksum="9ECBD81D599D3474" modified="2013-09-18" version="1">MGCDCCGPPAPAAESVTAETPPPSDIGSCKDACRDGSDAATQVKEEEPANKEQDDDCCASGSCEEPNKDDAPECCRGKTSPCCNASCIDRIAIRECELSASHKPDATGCGSSSSSCNGAADGKACSKHSLSALDRYGATLKALGCICRALVALGQESCCETKGRSVVTKQCSRKSSSRSLIRKSTDYCCTTGSVTKEKAAENRLRLRKGSNESARSAKQPSVKESCTKPCCSVVKPDKEAASKKCTSSCCSGDNGKYNCADPKPVKDKDKDNCSAGCCSKKAAPKSPLVEKSCASNCCSDGDLSKKIVESSGCPDKCCTTQPEESFTAKNGRVAEVAKSNCAKSCCDEEIAAIVKELPKSTYASSCCKPAEKIVTKSSDSCANSCCEKAPSITCRDSPADACCVSTSPERRVKIETTQNPADVEKQATGKEHVVLSISGMTCTGCETKLNRTLATVPAVNDLKTSLVLSRAEFNIDLRLGSVDEVIKHLERTTEFKCERLQTKGSSLDFIVNGSTSEFTGQAWLEGVLDMSLVDKDTVRVSFDPKIVGARDLAERSWDPPVQLAPPRGDSSLEAGSKHVRHVGYTTILSAVLTIPVLVMAWAPLPEREVAYSSASLALATIVQIVVAGPFYPKAIKALVFSRVIEMDLLIVLSTSAAYVFSVVSFGYLIAGNPLSTGQFFETSTLLVTLIMVGRWVAALARQKAVESISIRSLQSSTAILVDEQTGTEREIDARLLQYGDVFKVLPDTRIPTDGTVMSGSSEVDESMLTGESKPVEKQFRGVVIAGSINGPGVMAVRLNRLPSENTINAIAAMVDEAKLSKPKLQDLADRVASYFVPVVVALTITTFVIWVAIGITVRGYGGSKATTEAITYAIAVLIVSCPCAIGLAVPMVIVIMSGVAAERGIVFKSADAIEVAHKTSHVVFDKTGTLTQGKLSVVANECVDESTLPLLLGLIENSRHPVSMAVTSYLRSIGIEPLSVGEPKSLTGKGVEAVVRGQRLKAGNSTWLNLSDNPPIQPMLSQGHTVFCFTINDELQAVYGLQDEPRKDAFAAVEALHMRGISVHVVSGDDDTAVQNLASKLNIQQDNVRSRTSPSGKRDYIQTLLGTSTDHKKPVVVFCGDGTNDAVALAQATIGVHMNEGTDVAQSAADVVLMRPALGGIITMIDASRKSVNRIKFNFGWSFVYNTFAVLLAAGAFVNARIPPEYAGLGELVSVLPVILAAVLLRWSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPZ4</accession>
    <name>S0DPZ4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to growth regulation protein WHI2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426705.1">
        <property type="nucleotide sequence ID" value="XM_023572614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPZ4"/>
    <dbReference type="STRING" id="1279085.S0DPZ4"/>
    <dbReference type="GeneID" id="35397617"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04136"/>
    <dbReference type="HOGENOM" id="CLU_008613_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="147"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="690" mass="74840" checksum="89869C8528EA6029" modified="2013-09-18" version="1">MSYKRSRATYEADLHAAFATFGTPLPNDPDARDDGSFIPVWKQEVRDERGRKRLHGAFTGGWSAGYFNTVGSKEGWTPSTFVSSRNNRHKDAKNQSQHRPEDYMDEEDLADAAEAQKVQTSQAFAGLGSSGQDPNTGGLMGLLRAEGDTMGLKLLRRMGWKDGQGIGPKIRRSARLELGDKSSQATETHLFAPDNAKMIQFVRKNDRKGLGHDGETKLSSLNPITSAADDDEDEDYSHDNGLRDSSLLSQKSKTKPGRGGIGVGILNDNGSDEEDPYEMGPKIRYNRIMGGDKKKKKAKKTTAAINPALKNAPVFVSRTARAGNGLGRCHDGRLPLDGFVLAKITEDLSDLFLEYAPPPVPEGWASSKSPIDQANPSDYKSTADAAKASTHDAKSRAALLGEKSLPGKSVFDYITSSARDRLAAASGNKNLPQGLGEVPEGFSMTEEERQQQVWDEAPQLDRETAIAAISRGSSGPYADNEEKKARYRTYLEHFATGSQPLPYKPKGMAFDDFARELSEFHNCARIFKPMTGFMASRFTTAKKPAIVSANGSETDLVSKPEPKIADPAEEAAKIGMYGQMTRTVEDFYPTRLLCKRFNVRPPAHSQAEAEAEPGSGTTSRDGGSGPMEDVKMNSTFPAGGIKSIEGAPTNTTAPAPEPEAVIDPHKNEAVEGKTAHDEVLRAIFGDSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ14</accession>
    <name>S0DQ14_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426597.1">
        <property type="nucleotide sequence ID" value="XM_023572480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ14"/>
    <dbReference type="STRING" id="1279085.S0DQ14"/>
    <dbReference type="GeneID" id="35397737"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04256"/>
    <dbReference type="HOGENOM" id="CLU_011914_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="251"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="502" mass="57038" checksum="715A7401862D595D" modified="2013-09-18" version="1">MASVTRSSRRAEAPHQHHPHHHLTPPAGVFAHAQGGGGGRNKRALDTHDRDFDAIKPKRTRLTVEIFAKGTHGLRDADIDNNKAAPPTRKPAATPTVATTTPIPPPPTTDSATSKPKQEQALTKHQSKVINGIKHELDRLQPQPSDTNTQEQGRKLRSQEATRFKSELSAYFPEYDEVIGNEPKEQQLFNVDTPIVIVDSDPRRAIPQTHHPAIEYPVRGYGDALFYNVFDCQQVDLGFLESQSKNKTIEDPLPDKLFQPIHRRAERLERSIRNTEKGRAQHERDQIIRLLEGLQGHDWLRVMGVSGVTETKKKTFEPARNHFIKGCQAILDKFRNWVLEEKRRKMEKDKARAEKEEEENSSSVEEDEAGDDSENGDASDSESPAKQLQEEAMARSKNAKGSKNRKSTPQPAVAKIPRPAKTAPAPKPPEPPKEFKSFFSKRYERDSALHRHRRAGRKIMAWGLPMPEIPEVDFDLPEEYRGEDTLKARARQQRRERRRSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQC7</accession>
    <name>S0DQC7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425683.1">
        <property type="nucleotide sequence ID" value="XM_023571367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQC7"/>
    <dbReference type="GeneID" id="35398731"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05250"/>
    <dbReference type="HOGENOM" id="CLU_2236804_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="105" mass="10671" checksum="DE4AAF460F766DB3" modified="2013-09-18" version="1">MANHIYSSNVTINYYGSGYGGSGRGGGHGGSHGGDGRGGRGGGRGGVVSKKRSNRHAEQNQSPPTAGDNETPILDSNDESPSSAHNNEAESPSCGREVESSITNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQT4</accession>
    <name>S0DQT4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426891.1">
        <property type="nucleotide sequence ID" value="XM_023572837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQT4"/>
    <dbReference type="STRING" id="1279085.S0DQT4"/>
    <dbReference type="GeneID" id="35397416"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03935"/>
    <dbReference type="HOGENOM" id="CLU_505309_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="192"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="539" mass="61197" checksum="BED52E016B832789" modified="2013-09-18" version="1">MPSKTEFDAEIEGERFIELNLEIHALILSVFGCPENYPAQAQLKYLDSLEEIVRFVPIPVSYWRDQVGRSLHQCNILAGKLVDLLGKARLEGNEHHGWGTKFGLQRRKDIDRIFVEINAEIDIIMLQVAKSPNRDLSKVDTVTLLPRADKAMKNPMFTVASAKIIRNPFAADPVTDRDVIKTTKGETVQGKWDWVLQTPEFIKWRTSDDNSIWISGGIGSGRTLLAVYLTEQLQLTMTSDEILLYYFFDARLELRNNAACLVRSLIYQLVQLDKDGKQGNHWWKTRFQFLWYMFIEILQDLKGCRVICVLDGLDECESRSLDLILKKIKLDIPGLPIKFAILRRVAPPALEDLMSQYLRVNLDAPFRVDALRQYISASLSALPEVKQLPTSVNSLVKDLLQGRSAASYLWTHLALQSLQQVKADPIWVDGERDSMVALLLPVYARQEAKKAILAKDSFTPAAERGPENVITGSFFDAAVYSTTSLKTMKALLELTGPHDMNRERNEFSLSRARTHGKRAEVIQMLIDDYGYSISDFDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQT7</accession>
    <name>S0DQT7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to nuclear transport factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_00489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424989.1">
        <property type="nucleotide sequence ID" value="XM_023573236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQT7"/>
    <dbReference type="STRING" id="1279085.S0DQT7"/>
    <dbReference type="GeneID" id="35393974"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00489"/>
    <dbReference type="HOGENOM" id="CLU_003886_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT62908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1047" mass="118512" checksum="BCC5EE904ADD85EE" modified="2013-09-18" version="1">MSFPIEVPGDANPLSLQSLYQTLQSATSTDYAQRQTAGQQLTSWELQPGYYSSLQAVYLDKSLAYEVRFLAIIQLKNGIDRYWRLFNQVKNSIKPEEKSLIRSRLFQGSIEEEHTNLALHNALVVAKIVRIDYPGEWPDAMGNIIELLRSSRNGNQRHLHGILEILLRVVKELGTARMRKNQTALQSVTPEIVHVLSEVYSEKSQAWMGFLTGGPGGQEEANLAMLNSLLALRVLRRLVIMGYERPHSDNTVEQFWTLSQNQFGQLLNLVSHDSAVPPNYQEVVGKHLLQFTKLHIDMAEQHAASFVFLPNSIPLVQSYWELVAKFAEVFDKSGGIRQGPSETGSAKSKVEGPVLERLALKGLLLLRSCVRIGFQHVQTFRWRSPEVKAEQEKAKNLIKSELLKPDLVIQIVNSIITHLFVFRKSDLEGWEEDPEEWEQQEQSEGNAYEWEVRPCAEKLFLDLLTNYKDLLVPPLLSYFQTAQDPQADIATKEAVYTAMGLAAAHVHHVFDFDAVLASTIVNDARLQGGLCKVLRRRIAILVSQWAPIKLDDSSRPIVYQIYRHFLNPDDETNDVVVRITAARQLRWIADELDFNVDAFLPYTSDVLSQLINLVQSVDVDETKLAILESIRILVTRMEEQVSQFGDQLMSALPTVWENSGAEEYMIKQAVTSIFAALVMSMGPDSQRYQHFMLPLLSEAARRGSDLHLHLIDESLELWNNILMQSYAPLAPELVNIAELVLPLLEYDSETASLALTAVESYILLAPASMLEDRLRRPTLSALSNILDSKSREQVRMGTSCIENFIRAAVELGGSTGVSVILQDMVEIGFMNKILGNLHDAWESHQTTGPNRKVSKLSTITETDYFAILGRLALAEPTLFSQMLTNMGSLDQVWAWLSSEWFSHMSSMDHIERQKLYLLGLTRLLELPSPVQELVLSKLQDYFDMWINVISDLQDGVANGTDTLIWGPLETTEYDTPKIIADRNMEAKDPIHTVHAFDFVKMRLQDLVNRVGGEQAFQEQWAVNVDKEVLDKFQQMASGVQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQX9</accession>
    <name>S0DQX9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_05016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425903.1">
        <property type="nucleotide sequence ID" value="XM_023571628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQX9"/>
    <dbReference type="STRING" id="1279085.S0DQX9"/>
    <dbReference type="GeneID" id="35398497"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05016"/>
    <dbReference type="HOGENOM" id="CLU_012945_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="694" mass="78609" checksum="13B51385A92D6307" modified="2013-09-18" version="1">MGDYYHHFLSSMSGAGMNPATSPEEMLDPRMHGAPMPMVSAPLPGPYQQLGYFTGFPDPMMFNQNKSQKARRKSAAGTPAAVDHVKHRRTRSGCFMCRSRRVKCDETRPICERCKKGNRECVYPDPPSSKGSSASSGKSKDTATSAQQTSPTSSKSEDDEDIEQESKLEMIVDQEEDTEDQTKSSVLSRQSKSVSPSTATATPSSLAAVYSSSEFPIQTGEADWSHLPPEYQQGLSFFVENLNHFNYCIPLDSDGFFTKILPNMATRHEPLLNALVGFSAYHITLRNPQGKLQDFLQYYNKSVTQLLGLFKRREKPNVATLLTILQLATIEEYFGDWVNLMGHQKAAFEIITSIFTPQTVMQTPVGRMCLSWYARFDNFVALMGGFPTDLPREWFQAMLDFYQSGITSNPDELHWKIDAWSARLRLISYDMSILFARGSRGQISQEDFVKEHELLNQQLIEWKEKRDPALQDPKYLIKDFPPAETLDPDDFVNPYTVGILYDFPLFDVTVLCAEWNSIMIMHKCQSSGMRPDQLFADLNRHAYRTCQYFETLEFWPSTPRGVLVLIQACIAIAALFCPQDARHHMWFRRKFALLETMGYIHPLPLRTKMAELFREPDCVNWWLPNEEGFSPVLQEIRNFADERNAAAVTAQQESVREVRHIFAKMSLMDDANAPSSSSPDSASGPSVDSSGAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR36</accession>
    <name>S0DR36_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to acetyltransferase, GNAT family family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427095.1">
        <property type="nucleotide sequence ID" value="XM_023573081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR36"/>
    <dbReference type="STRING" id="1279085.S0DR36"/>
    <dbReference type="GeneID" id="35397196"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03715"/>
    <dbReference type="HOGENOM" id="CLU_073919_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF4">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_4G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="228" mass="26194" checksum="B0D8D120F388BC26" modified="2013-09-18" version="1">MGISITDLTEADIPGAVEAVQQAFVGDPYNVWVYDQTKFDRQRNFESLAIRMRWGMRNGIFHVAKEENSDKVLGVAMWLRPQPADQPPTWNDWFESWKLYFGQIRMNLWYGRGGLNVKRYYIWKDAQASAQSSLWKDPRGYFFLNIMVVVPEAQGKGVGAKLMKAVTDEADAKDMRCYLESSRDVPNVAIYGRLGFKFQKEMICDDDGDAIKLFTMIREPHAEPSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR85</accession>
    <name>S0DR85_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to solute carrier family 35 member F2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_00357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425114.1">
        <property type="nucleotide sequence ID" value="XM_023573383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR85"/>
    <dbReference type="STRING" id="1279085.S0DR85"/>
    <dbReference type="GeneID" id="35393842"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00357"/>
    <dbReference type="HOGENOM" id="CLU_039639_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT63033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="409" mass="45126" checksum="8FEFDF59E3F71FE6" modified="2013-09-18" version="1">MSATQPIAVNTPENPSSEGDSKGPTANATQASIATNEDAAVSQGIHTLEVKSVHWYSYLTTLDFWIVLALGQVLALCITATNTFTSFLANAGTNIPAFQTVFNYILMFLIYTPIFLWKDGIKGWWRVGVKDGWKYLIMAFLDVEGNYFTVLAYRYTNVLSAQLINFWAIVCVVVISFFLLKVRYRIFQIIGIVVCCGGMGILIASDHISGTNGGSGLDMVKGDLFALLGATLYGTTNVFEEWLVSRAHLYHVLSFLGLFGMCINGVQAAIFDRNSFDNATWNGKVIGWIIGYTLCLNIFYILVPVMLRMGSAAFLNISLLTANFWGVIIGIRVFGYKIHFLYPIAFVLIIIGQLVYFVTGSMLSDSKKPWLGDNQEDGVLGFGTAKLKALNAARKAQIEAEAGQRDTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTI4</accession>
    <name>S0DTI4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426773.1">
        <property type="nucleotide sequence ID" value="XM_023572694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTI4"/>
    <dbReference type="STRING" id="1279085.S0DTI4"/>
    <dbReference type="GeneID" id="35397545"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04064"/>
    <dbReference type="HOGENOM" id="CLU_921466_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT64692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="341" mass="38025" checksum="979A4A37EBA7B563" modified="2013-09-18" version="1">MFNTWKQNSNSYVVLPTGPPFEKAQNGKPRRSACNPCRTRKIRCTSEPDGCRNCRSRDLQCEYGTESDTDHNFGSVKGRRQVKQKETTGSRSGGLMTPFTDGSYSAEDDSGNLQSSNMSEAVVQEPEGMYSELHHMEPDWSEFMFGSPQDISSTPTNSRDFSHDTTFDMTVSMDQVLNSPGSFLTSPPLEAMLDEDLYPHDSFPFPQSGISTSGIWPTRTGQLHDQGPSDDRKSSCQCSITPMETWEALTINVSSKHPTSQKSIQAQKSAISRCEEMLHCSKCSSQSRNVILLIDICAKLLDSLKLQDRDLQADHQQVEHRPAEFMDVEDEKVGPVDSEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTP2</accession>
    <name>S0DTP2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_02798</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427902.1">
        <property type="nucleotide sequence ID" value="XM_023574572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTP2"/>
    <dbReference type="STRING" id="1279085.S0DTP2"/>
    <dbReference type="GeneID" id="35396280"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02798"/>
    <dbReference type="HOGENOM" id="CLU_046484_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TNase-like" evidence="16">
        <location>
            <begin position="85"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT65821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="268" mass="30910" checksum="74B599D2BCAA4DE2" modified="2013-09-18" version="1">MIWPFGSRDADNEKEQKLKEEAKRQHVSWTDSINRIRSAPVDAAREWAPVVLFPLAGMAALQIYTNYVRRIPGSAYVRPNFFRNRSIFGRVTSVGDGDNFHLFHTPGGRLLGWGWLRKVPEARKELKDRTISIRIAGVDAPECAHFGRPAQPFSAEALAWLRNYISKRNVRAYVYRRDQYDRIVATVYTRRWLFRKDVGLEMIKAGMATTYEAKQGAEFGGRQKIYERAEAKAKQKRKGMWSGKSKDFESPRAYKTKWAGFDQEKPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTZ1</accession>
    <name>S0DTZ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to 442K curved dna-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428002.1">
        <property type="nucleotide sequence ID" value="XM_023574693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTZ1"/>
    <dbReference type="STRING" id="1279085.S0DTZ1"/>
    <dbReference type="GeneID" id="35396389"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02907"/>
    <dbReference type="HOGENOM" id="CLU_041451_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000016">
        <property type="entry name" value="Putative curved dna-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="405" mass="44380" checksum="36F6D61BDB90DAB1" modified="2013-09-18" version="1">MSSETKEIDYSLANPDTLTKYKTAAQISEKVLAEVSKLVVPGAKIVDICQQGDKLIEEEVAKVYRGKKINKGFSHPTTVSPSSYVTPYTPLTSDEAEANTEIKDGEAIKIQLGAQIDGFGSIVCDTVIAAPEDKAGDKITGRTADLVLANYYVNELLLRLMIPPGLLTQGSEEEKAKAASQKAPTQAKITSLLEKVTKAYEVNLVESTTSWLFDHNEIEGSKKIVLAPAEGTKGEGVPEVGEVWGVETGVSLGSGKVKGLDQRATLHRRTNQTYGLKRPTSRKILNEVQKKFGIFPFSLRQLEDERDAKSGVVECVRGNVFRQYELVGDKDNSPVARYLTTLAITKNGITKLGGPPPLDLEKYESDKKIEDEEVLKILEQPLARNTGKKKSKPKKKTAKKEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU10</accession>
    <name>S0DU10_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Adenosine kinase</fullName>
            <shortName evidence="12">AK</shortName>
            <ecNumber evidence="4 12">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_02932</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 12"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428026.1">
        <property type="nucleotide sequence ID" value="XM_023574721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU10"/>
    <dbReference type="STRING" id="1279085.S0DU10"/>
    <dbReference type="GeneID" id="35396414"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02932"/>
    <dbReference type="HOGENOM" id="CLU_045832_1_0_1"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1110.10:FF:000001">
        <property type="entry name" value="Adenosine kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000014">
        <property type="entry name" value="ADO1p Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="13">
        <location>
            <begin position="27"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT65945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="347" mass="37949" checksum="7F817020F8013072" modified="2013-09-18" version="1">MSAVKEYSLLCLENPLLDIQAKGDQALLDKYGLKPNDAILAEEKHIPLYEDLLNNYDAKLIAGGAAQNSARGAQYILPPNSVVYLGGAGDDKYAAILHDAVKAAGLRVEYRVDPKEKTGRCGAIITGHNRSLCTDLGAANHYDLDHLKKPEIWKLVENAEVYYVGGFHFTVCPPAIMELAKQAAEHNKPFVLSLSAPFIPQFFKEVVDASAPYWDYIIGNETEAAAYAESHDLPSKEPKDVVKHLANLPKENTKRKRIAIVTQGTDPTLVAIQGEDDIKEFPVHAIEKEKINDTNGAGDAFAGGLLAGILQNKPLETSIDMGQWLARLSIQELGPSYPFPKQTYQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUI0</accession>
    <name>S0DUI0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428197.1">
        <property type="nucleotide sequence ID" value="XM_023574924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUI0"/>
    <dbReference type="STRING" id="1279085.S0DUI0"/>
    <dbReference type="GeneID" id="35396595"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03113"/>
    <dbReference type="HOGENOM" id="CLU_031002_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="422" mass="46220" checksum="338CDEFC99FDE784" modified="2013-09-18" version="1">MPFVKNHGRQYDIVVLGATGYTGKLTAEYISMHLATDLKWALAGRNSGKLKAVVEECQKLNPDRLPPAIEVVNLNDADLSVLAKKTCILVTTIGPYSLYGEHAYRVCAEAGTHYVDVTGEAAWVHKMIKKYEATAKQTGAILIPQAGIESAPADLITWTMAKAIRTDLGSQTRDVVVSLHKINSAPSGGTLATALSIWDVFSLQEIKEASSPYAQSPVKHKDPTRPKSSILQMIFGVRTVPNLGLQTTSVTNSTDVAVVERTWGLLSSTPSRKDEFYGPNFVWVEHMKARNWLHGIFIHWLLIVGGVLLVSVAPLRNFLKKRVYQPGEGAKREDTAKDEIEYRGIAYPDSEKAAGKAALCRMWYHGGMYFLTGMLLAEIAATILEDDIELDGGSYTPACLGQGLVDRLDKSGFRTDVKIIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUI1</accession>
    <name>S0DUI1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428330.1">
        <property type="nucleotide sequence ID" value="XM_023575089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUI1"/>
    <dbReference type="STRING" id="1279085.S0DUI1"/>
    <dbReference type="GeneID" id="35396744"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03262"/>
    <dbReference type="HOGENOM" id="CLU_016815_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="294"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="496" mass="56783" checksum="5B1CFAC9DC6936FD" modified="2013-09-18" version="1">MSALHAQLAILQQLLGNGVRLEERPRDEEDCNENSDNTVGKGADNNYGGMMERQRQATREQISQTVQQQEANTYAARRHELAEKKTKAFNNSEFRIFQAVSKDFTFCPFKVVVSYPERFVGKANKPRTKPFFTRILFEKTWDFFYLHDPEEPARDPYLLIPTAQFEVFLEEINLELDTSLKIPPGVNMEKFYLKFGEHGTPRPRYLKRSEEETSLDARPWPAIDQDDIKGFKAATPKQRLAWKAKFRIVKSGFPPRNRADPDKVARKKSHRERMLRNTQRCLGLLGDPDGYDVVFICVDVEAIERRPNPVSEIGIAILDTRDTKGVDPKIVGRGWWPLIKTHHLRVYEFAGLRNYQFVKGCPDDFDFGTSTFPTNATVADSIMEIFNPWLNDQRNIAVVGHDVKQDITYFTELGLDLRFLGGLAEPVDTQDIHQAWRGSTNGRSLGAVLNDLDIAHKHLHNAGNDAHYTLCAMLGIALEDIRKEEELSNEMLNKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUK6</accession>
    <name>S0DUK6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to peroxisomal membrane protein PEX17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428360.1">
        <property type="nucleotide sequence ID" value="XM_023575125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUK6"/>
    <dbReference type="STRING" id="1279085.S0DUK6"/>
    <dbReference type="GeneID" id="35396775"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03293"/>
    <dbReference type="HOGENOM" id="CLU_016177_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26001">
        <property type="entry name" value="Pex8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="685" mass="75439" checksum="6BEDFC267D7E6BFA" modified="2013-09-18" version="1">MSSDRLLRTVLQHYPDVHDAAKTEQIIGSTTHLLTELTNPLNLGLLTSQLLTAPAIWFQPGGIRTSVRVISIYNTAAARIHNYEVANRDRKEPHEGGGLSCEEWTRAVVKGADDRSRRWQHLLVLTGVLMGMESSNRQSLSRGMRNTLEEAVVMAANLALESRDEDGPVAGASVVMALNFAFPLLSDFHRSLINCNALLPLIVWTVTAEEGLGHGQFLAAVSSEVVESPNHLLAWSPNTPSFRFIQELDRRPTLANMGPLAKLAGYAVQQATDTQAVIAAQDALLAFSSQVLDMWRVNRLSDIDPALEGNVLTQETITSTWPVLWNLLRKLMFGTVAILQAIVSRSLLDPRMLNDMAAPVIASKSLRILRNIFFISSRNGNNAFQVYNFTYLTSIDSISRSAPACHSFLQEFRPSEDASTSTTYLQRTLDLFYLNISEHLPLTLPTDACDALIIKPAIAYISHEGPTTQNMVEIFESAHSAILSTISCPQHSPLTIELTPFYIALLFNSFPQHISSRQFRVAFKTVMQIVSPPFPIAELEPQLSETLLEMLRTSISTASTSLLPPTADIIAQAAMEETQEERHSQQSSLALALVDSLPYLPLPLVEEWFTIAAQAMNEIEDPVLREPVKQRFLQILVSGELDVERAAIGVAWWGTRGGRALIHGASAEPAMMSGALPGPDRSSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVW9</accession>
    <name>S0DVW9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428696.1">
        <property type="nucleotide sequence ID" value="XM_023575527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVW9"/>
    <dbReference type="STRING" id="1279085.S0DVW9"/>
    <dbReference type="GeneID" id="35397138"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03657"/>
    <dbReference type="HOGENOM" id="CLU_035834_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="52935" checksum="6E93917F1B04FDA1" modified="2013-09-18" version="1">MQRLKKFLSKRHSTHGPGISAPEPTPANPPTSSSTDTRTFSRGSIDLSRIERLPFEIRNEILLAVDSIADLSSLLHASPTFHQQFRLDRAFWLWHCLKQEVGNVIIDAYNVNNLKTPEFQSTRTRQKVLLYVEDYKQQRSEGIESLAQPPEDYVIRIVSFHTSVIRALMHQYAAWARANLEGLAEPQELSRTEATRIVRGLYRFQIFCSLFGPARGGYNYYFYEDRIMNAGQRLQQLDDLYEAWEIEEILCINAFVHAKYRPLFEQVEWDLNPDNPSFDDKRTGPHTPPGAFHLSSRMFGDYYRNGIVCRGLPVLFAALKIPSHVELVKLIADNVVSVADDMISETTRPYHQDIRRDNHYSDRDKAQDNRDRMCFEGESYDSPPFAWVAFWKESYSNLYGDYIPQSFHTWGYVMWDKTRLANADAAAIINREWDAMYNRPNDEGIPEDPRDEWTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVX5</accession>
    <name>S0DVX5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to sexual differentiation process protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_04121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426719.1">
        <property type="nucleotide sequence ID" value="XM_023572631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVX5"/>
    <dbReference type="GeneID" id="35397602"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04121"/>
    <dbReference type="HOGENOM" id="CLU_004965_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT64638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="819" mass="92178" checksum="5A2BA3EE84BD1AA9" modified="2013-09-18" version="1">MAKLMHELKSPSRTPEVEFTETSSDSPSPDSREAVGYESGFERDLDVTQDDLLEAREVASTLSLEDVHKTMKRVYTLHKRDPNFPLSVIKKIEVFLGMGPNEHPTITYSYQTDTDDILQHPERHEALIQEIKIEAALITHNSPYAEVRAIVSNRDDPSMPCSTIRAWLVGIIFSCAVSFINSFFEIRQPMIGVNTVVPQLLAYPFGKFLEKTLPDIGVTVFGVRHSLNPGPFNKKEHMLITIMSSISMGTPYTNYIVWIQYLPFYFNQPYAISIGYQLLLGLSSKFIGYGLAGICRRFLIYPSYCLWPTTLVCIALNTALHDEADMAVPGPFKKIWNTSRFKFFSLAFGAMFAYFWLPNYLFAGMTWFSWMTWISPNNRDLATITGGHTGLGLNPFPTFDWNIVTMGCDPLMVPCFTTFNLFCGTMLSFFVILGVYYGNGYYTSYLPVNSNRAFDHFGGLYNVSAILDERGIFDPEKYEAYSPAFLTAAHLGSYMMFFAMYTAALTYGALYHHHQIVLGFKSLVNSFRGSKKGDIEDGQVLDAHNRLMKTYHEVPEWWYLICLALAFVIGIVGISQWPTHTTPAVVPFGIILSLIFVVPVGIISATTGIAVPLNVIAEFLGGSFAEGNAIALCFFKTFGYTACAQAIYFSADLKLAHYMKIPPRFTFWAQMVPTLVSTFVSVGVLQYQIHLEGVCTTNAPYRFTCPGLNNFFTAAVLWGTIGPKKLFGPGGQYVETLVGFPFGVALVLLFWWLGKRHPNNNIIRSTHPVVFLGGGMIWAPYNISYIWPAVPIGWFSWMYIKKRYLAFWAKAGLQMSYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXG1</accession>
    <name>S0DXG1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_04012</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts with preproteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427239.1">
        <property type="nucleotide sequence ID" value="XM_023572753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXG1"/>
    <dbReference type="STRING" id="1279085.S0DXG1"/>
    <dbReference type="GeneID" id="35397493"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04012"/>
    <dbReference type="HOGENOM" id="CLU_023309_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="17">
        <location>
            <begin position="211"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="44"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT65158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="503" mass="56901" checksum="58D7B1B8C1995A10" modified="2013-09-18" version="1">MLSRVAQASRLGLMTARLSRPVASPSLRALPAAAPQFASPWLRTYAKKSSSQQNKDSKQKPSQAQNDAENVEKPAENDIDKAGEKSTEAPKEGEQIPFHKLPDLTQGIPSTLFEEMGGDKKKEQKELQEMEEAESSGGPFMLITAAAGGTLSALYMGRNWEDTIEAERHSDIPNGPGLGLWWKRAKARLTESVTYYQEPAFEKLLPDPDPSFERPYTLCLSLDDLLVHSEWSREHGWRIAKRPGVDYFIRYLSQYYELVLFTSVPFATGEPIMRKLDPFRLILWPLYREATKFEDGEIVKDLSYLNRDLKKVIIIDSNPKHVRNQPENAIILDPWKGDRNDKELVNLIPFLEYIHTMQYEDVRKVIKSFDGKHIPTEFARREAIARKEFQAKQLAHKQKHGSGVGALGNLLGLNPSNMSMMVSPEGEQNPAEAFAQGKMLQDVARERGQRNYMELEKQIRENGEKWLKEEAAMMEAAQKEAMNSMMGSFSGMFGGSPPPEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXK1</accession>
    <name>S0DXK1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to chloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427284.1">
        <property type="nucleotide sequence ID" value="XM_023573822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXK1"/>
    <dbReference type="STRING" id="1279085.S0DXK1"/>
    <dbReference type="GeneID" id="35395609"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02126"/>
    <dbReference type="HOGENOM" id="CLU_050230_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT65203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="265" mass="29836" checksum="EC33B21121751B51" modified="2013-09-18" version="1">MPPSLAVGEFAKAPPGASRSPCPVVNALANHGYLERSGRGILMDDLNASMKHVGMSSLLGSVFAIPTYFEYQNPAKAYMKKPVSTRQRIWSLIKNPYSFFDYFGCWNSKQISDGKKYLNLVDLASHGAIEHDISLSRRDIAQKQGNNDPQEDLIEEMLDYSFDGETLTIQDLARFIKARISRQLEDNPELVYGPAEHQVNCGQIALMMGCFGDGKTIPVKYVRAIFEEERLPIDEGWKRRSWWTMGLVEFFGAVKKLVNTVGVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXT6</accession>
    <name>S0DXT6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429432.1">
        <property type="nucleotide sequence ID" value="XM_023576257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXT6"/>
    <dbReference type="STRING" id="1279085.S0DXT6"/>
    <dbReference type="GeneID" id="35407012"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13558"/>
    <dbReference type="HOGENOM" id="CLU_093893_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="2">
        <location>
            <begin position="68"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="246" mass="26799" checksum="DEDBEFB55FE708C9" modified="2013-09-18" version="1">MDLVGQLRASILAQNLPHPSTAFLNSLITTRSPPPPLPSLLATAKARLLAADLTGSTIINTGSLQSFPSDADSTESREKRIPRPVHVQVLDIENLASSRWEQVEEMEAVARGETTRGREVVRVTAEDDDEDGVDGPTQRPPTSRNTAGPKPAGKNATHRLVLQDCKGTKLFALELRRFDSIGVGRTQIGEKILLKAGTVIARGMILLEPDKCVMLGGKIEAWQKTWVDGRLARLKEEIGQNERQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY21</accession>
    <name>S0DY21_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427439.1">
        <property type="nucleotide sequence ID" value="XM_023574008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY21"/>
    <dbReference type="STRING" id="1279085.S0DY21"/>
    <dbReference type="GeneID" id="35395776"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02294"/>
    <dbReference type="HOGENOM" id="CLU_013985_18_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="183" mass="20413" checksum="9F8D072239A3EA50" modified="2013-09-18" version="1">MTAKDSQHPHKEVIIKPATLADAARIAELGSHVFTITFGHSVEPHELSAFLEESYTEASIINDLNDTNKDVIIATNSDDDFLGFAYLTRGSSEPCVENMEKTVELQRIYVHPKSHGAGVGKALEKAIESMAKEQGFKNLWLGVWEENPRAIRAYEKWGYKQVGDHDFTIGSIVQTDHIMVKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYB3</accession>
    <name>S0DYB3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_13656</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429526.1">
        <property type="nucleotide sequence ID" value="XM_023576366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYB3"/>
    <dbReference type="SMR" id="S0DYB3"/>
    <dbReference type="STRING" id="1279085.S0DYB3"/>
    <dbReference type="GeneID" id="35407110"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13656"/>
    <dbReference type="HOGENOM" id="CLU_075666_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT67445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="137" mass="14791" checksum="C2C8E23F002BD6EA" modified="2013-09-18" version="1">MAPKAADKKPASKAPATASKAPEKKDAGKKTAASGDKKKRSKTRKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERVASEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZJ6</accession>
    <name>S0DZJ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_02887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427984.1">
        <property type="nucleotide sequence ID" value="XM_023574670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZJ6"/>
    <dbReference type="STRING" id="1279085.S0DZJ6"/>
    <dbReference type="GeneID" id="35396369"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02887"/>
    <dbReference type="HOGENOM" id="CLU_005843_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001167">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="5">
        <location>
            <begin position="560"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="4">
        <location>
            <begin position="949"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1052" mass="117154" checksum="D0E7233F5E6AF773" modified="2013-09-18" version="1">MDRPEPGLVKWSSNPSYDNFIHINLQHRVVQVYEPTGHARAGKFDYQKLARHDDFPPLTTYDWSPTNPGLLAVGTGSGIVNLLRIDDGSNAYVELGLKMSRTCQAVAFNTTGLLAVGLDRVRMDQCLHIWDVSRLSSIDKNTKGFPSDATNIAEPKTRLEPSVSVSSIKFFEDSPQTLVVGIKAQGLRIHDLRDPSSIVTFQTKCNNNLTIDYADQNYFASSALDHPGVMIWDRRATSRPVASHAYMQAIEEDELPWGGALRLDRVIETDSDPFLAEGKYSLVRSLRYCRDHRGLLAVLSRTGQLKVLNTNKEAPSSGSSNPELLQVQKSYEMDVSYVETSRKNDRIVAFDWVTLSSPVLRPRLLVLRANGNFEILEQPSQTSDHVYKLVPWKAPHRGLEEGAPYHSMMQFEPSQAPHILGPLLIEEALSEVPLFGPESANVRADTETLLKANNMTSVVIEDIGATTRPLPEAFHKASAVAAKIRVLRAFVRDEFQAPKGIKPRAGDTKIVESETSEMSLASDSLGSCREIHDALLASLAEAEGLPREAQNVLDHNMLLRAKEKYLFDAVANRDIVADDPWVKYIWDWVATAEDNADDGGMVLSNIDLSYVGVHSIWTNNLGRDPSTRLPPGATPPDRATWERTIASFCKKNHLPKFNGAATKWPAHRQLCLEICGWGDSEKHDPKGRNRKADPEYPTTIHTMAAARALFTGDHKEAIQILKKASTAHPELLFVSLALQLMGSGDSTPAKNKEQLDFDEAVASKTDPYLRAISSLIATGDWTAIANQLSLPLSDRVYVAIRNFDDDQLTQWLNEQITLAIADGDIEGIVLTGITEPMVDIFSRYIQKFHDVQTATLVLSICAPRYIDDIRCRAWRNTYRAHLQRHKLFFQRTKFDVESTKRSKRDGIPKLKPPSRQVALRCVFCDAETSLANNANQTPHIGGASSAPAASALESRNPLLATSINAGVSCPNCGRHLPRCIVCLEIVGVPRSDKPEEKSESKMAGQFPTFCLRCEHVLHLDHARQWFARHVECPVPECRCRCNFRANPELSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZN1</accession>
    <name>S0DZN1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to helicase-like transcription factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_06784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430109.1">
        <property type="nucleotide sequence ID" value="XM_023576963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZN1"/>
    <dbReference type="STRING" id="1279085.S0DZN1"/>
    <dbReference type="GeneID" id="35400261"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06784"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_7_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="210"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="558"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT68029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="741" mass="83585" checksum="C2D13B5A6F230A4F" modified="2013-09-18" version="1">MVNIRQCGSIIKLSTADTGAYAGLVADFPSDSLHRPSVKLSALLTAPASLRVIVLSPIEEAAEIGNLLSNNDLFLQHPSSQDIEYFDLEMEYFNPHYLVIPGSRMPQLEDLAIEYNDSTSAHSLTLDEQKKSQLIGIFDTAADLSIRPTTEPSPRLQTRLKEYQLKALTVMSEKECTNVESPQCPSLWVVRDASNGKDREYLHRITGHRANVVPTCAGGILADEMGLGKTLCVLSLICWSLDSLRDAEAQGIGSESLTTLVVIPKSMIPGWQAQIESHIMPGQIRVALYHGTGRQNIARHFRDNGIVLTTYQTLRSEWTNKGPLFREPWFRVVLDEGQYCHFATLYMWLMVAAHRIGNRSTQVFQAACELQSLRRWCLTGTPIVNSIDNYGALLAFIGMKPLDAKGRFDHWITNPIRDNEQEGLRKLRILVETTCLRRTKFSISQALPPPTVHEEKVDMHPYDRALYDFFESEAAKNAADSSKSYPANPSAAGREKKNVLSLIQNLRRICDHGEDLLPASDIEAWNLQIFQRPSLRARQKPGTTFSDDSYCETSPSAKVQRLIQKLRLEQKSNFKESSFPPVKSVVFSYWTKMLDLVQKALFEASFLCARIDGQYSVKQRENALFRFANDPCCTVMLATLGSGGEGIDLTSANHVHLLEPHWNPMAEEQAIARVHRIGQQRHVTATNYITPDSIEEYVQSIQVKKTQLIQDTWRINDESDGNNIYNETSRLEKWLTQRSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E033</accession>
    <name>S0E033_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to SAP190-Sit4p-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430241.1">
        <property type="nucleotide sequence ID" value="XM_023577123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E033"/>
    <dbReference type="STRING" id="1279085.S0E033"/>
    <dbReference type="GeneID" id="35400404"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06927"/>
    <dbReference type="HOGENOM" id="CLU_003676_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="895"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="545"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="903"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1011" mass="110661" checksum="51B3E9693660FD5C" modified="2013-09-18" version="1">MFWRFGGYANISTIDTILDKPDFTLEELLEETDLIQELKQHNSKLIEYLRSDKVLDNLLEYVVAPKLETVESPDESTDQEAKAKNRFLSLSRPRASSRATDPGDDEEEQEKKRNRYAFVACEILSSDTWSIYEALAENRQLIRDFWNFLSRPAPLDPLQASYFTKVNESLFEKKTEDMMELLTTLPDAVPNLLKHVECPMVMDLLLKIIALDRNEGGQGVVEWLYSKDIIPSLLSCLSPENNWVVQTAAGDFIKAIITISANASQNEQQCIGPNELTRQLVSKPCIEQLIGYMLGGGNPLTVGVGIIIEVIRKNNSDYDPDMGTEASAAPSSRDPIYLGTLLRMFAENVPKFMNLIMDVPSKKEKIDSTFGVKLEPLGFDRFKTCELMAELLHCSNMGLLNEPGSEELTAQRDIERQRLRTEGKLAPLKEEDHSTDDLTMRSAAPEEKRRLEVTNADDDGFEEVEPSKEMSEDTSHEFVKAEDDIPGASTTSLSKDEDDFVDEPLSPPQMGAKGDETRFDDPDLMVAPLSPTKTKTAEPASTESAKGDSTEKPEAKEPSSEKNEETKPKTTLEDAVKDDTSDSSAILTPAPSEPESKAESTDASIKVEEQPRGISPQPDDMPAPLFSAPPPPESGADRPPQAAEKAAGDAQAVTAETSTTETKTKEDKPKEEQPTSQATEEPVVGDFLKLQFVEHRVVPTILNFFFAYPWNNFLHNVVYDIVQQVFNGPMDRSYNPTLAVSLFEAADITSAIINGQKASDESQAKTKTRMGYMGHLTLIAEEVVKFTERHPPELLSETVLDRVMSQEWISYVEGSLAETRERDNAILGGVRPEVAMGNRSMGGSGLGGVGLSGLSGGSGAGGSSALAEAGLNGGIELSQDSGNGIGPFTISGATLMSGFGSSSDEEDEDGDENEEDVNSEVSGVSAEAEDDGSDHGIPGSPGIAETLEDVIMRSPETFASQFPDLDYPEDVTRGSPMDLDEIVAHRQRSSQDEEQQHAEQVEDVSKPEGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E061</accession>
    <name>S0E061_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_03100</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428184.1">
        <property type="nucleotide sequence ID" value="XM_023574910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E061"/>
    <dbReference type="STRING" id="1279085.S0E061"/>
    <dbReference type="GeneID" id="35396582"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03100"/>
    <dbReference type="HOGENOM" id="CLU_046802_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484691" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="182"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="244"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT66103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="299" mass="32141" checksum="1347258B15AFA489" modified="2013-09-18" version="1">MIPGSLAWLLALPAFVLAARPKDAIKLSDVRSLTLRGNGAMTNHRRVGAIPQLRCVSKKALCGLYDVDVMRCTNEGSGWGDEDIQWSCTASLPEELKLVTTDVICEGYNSPDDPYVLKGSCGVEYRVALTRKGERRYPNIANGGWFNDGRGGTDWGALLFTTIFVSILAWILYSACYRAQEAGGNSNRPRRRRDGWSSGGWGPGWGPDGDDPPPPYPGSKPSSQSDTWRPGFWSGAAGGAAAGYWAGSRNQQNHHNHHNDGYGSIGRGGSGWGGRSGSSSGSNNSNRHESTGFGSTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0U0</accession>
    <name>S0E0U0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to 4-hydroxybenzoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_07265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430559.1">
        <property type="nucleotide sequence ID" value="XM_023577498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0U0"/>
    <dbReference type="GeneID" id="35400742"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07265"/>
    <dbReference type="HOGENOM" id="CLU_001265_52_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="114"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT68479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="582" mass="64003" checksum="12E4AEDC3DE31E60" modified="2013-09-18" version="1">MRISWRLGSGYVESVDDYIGVLIPLEEAHLYSQAAKAKGAGHGETREEGEMDDLEMKEEREGMLEGDAAEYTVDGLRKEMREGRRGQWTTYEIKSKLMNKAIGDIGMGSYNWQLFVLCGCGWFADNLWMQGVSLCLPSLSGEFGVDEKTVRYTTSALFVGLSIGSFFWGIGSDFLGRRIAFNTTLLITSVFGIMSAYAQSWGSVCFFFSALGFGVGGNLPVDGALFLEFLPDASSALLTLLSVWWPFGQLVSSLIAWYFIGNWPVEQGWRYFIVTIGIVTFAMFVVRFFVFHLFESPKFLLNKGRQHEAVAVIHGLAYRNGTKTWLTSELLDLVACEDGEDLAHVAEKKIPAPSTIGFLREKFQSFSGERLRPLFQNKTLGMATSLIWFCWATIGMGYPLFNAFLPQYFARAHNEASDNMQSETDTISSDTYRNYAIASVMGVPGSLLAAYLVDHPSPFLGRRGTLASSTLLSAVFLFLFVFYGTTSTAQLLMSCVEAFAQNIMYGVLYAFTPEIFPAPVRGAGTGVASFLNRITGLMAPIIAATVPGDGATTPIIMSAVLILSAFIGICLIPIETRGASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1A5</accession>
    <name>S0E1A5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_03502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428549.1">
        <property type="nucleotide sequence ID" value="XM_023575357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1A5"/>
    <dbReference type="STRING" id="1279085.S0E1A5"/>
    <dbReference type="GeneID" id="35396984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03502"/>
    <dbReference type="HOGENOM" id="CLU_028356_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="9">
        <location>
            <begin position="56"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT66468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="515" mass="57429" checksum="DDEAA9E22B63D32F" modified="2013-09-18" version="1">MASSSSKSSLRRSHGDSSGASSGHSHPRSATQSRLSTAPSIDIDTLVNHLLVAKRSLSSMTLVLRANEIANDARQSHDDVSILAAQAGFLRTSILDQTAILVRTRRSLQSTYEWGKKDFRKLVKSMDLVDGQLDLTMEMLRETGVESVFRPQGEERRSLLDFIDEGGVDGVREAMKQSIQELQAIQQSFDGDLLRFDNDIRNLKKVVADTPSIQDIPQGNNPSAGEILESLVDHSANMAQLLASLNHHFDMCVTAIRTTEGGVALARRRAAEATQSQGNDGVSISGVIAEQESNVSDLEPKTAKDRAEMLKVVVQDAREVDDVVQEIQERLTAMEQDYTVLQEQHDISKQAYTGMLQAYAILGDIGDRLADYLAAEGDFKTRWDMEKESVFAKLQEMQQLKDFYERYASAYDSLILEVERRRAVDDRVRSLWRKAQENVDKLLETDRVSREAFRQDVGEFLPTDLWAGMQGSAKKWTVVKEGEGDGDGEVQPLRRSVVEAAKERLARAGERRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1P2</accession>
    <name>S0E1P2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_07504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430776.1">
        <property type="nucleotide sequence ID" value="XM_023577764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1P2"/>
    <dbReference type="STRING" id="1279085.S0E1P2"/>
    <dbReference type="GeneID" id="35400981"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07504"/>
    <dbReference type="HOGENOM" id="CLU_1540153_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="190" mass="20337" checksum="BB67352C76AAF703" modified="2013-09-18" version="1">MQTEHLVNIIILGAPASGKKSFIRRYCQDVFTDLYDPITETSGDRRLANISGIPTIINLERIPSTFIQSAPESRRIATEADALILLYDGSSIESLEELLRIRLQVLAPHLGEAAPPTAVVAGKADGAEAAGSVWERGLGEGRKLSVLLGAKFGVVSALWGDGVKDVVEELAARVLERKGLEKDMLMGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1Y5</accession>
    <name>S0E1Y5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_07524</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430795.1">
        <property type="nucleotide sequence ID" value="XM_023577787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1Y5"/>
    <dbReference type="SMR" id="S0E1Y5"/>
    <dbReference type="STRING" id="1279085.S0E1Y5"/>
    <dbReference type="GeneID" id="35401001"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07524"/>
    <dbReference type="HOGENOM" id="CLU_021486_2_0_1"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000204">
        <property type="entry name" value="Inositol-3-phosphate synthase 1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2360.10">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="15">
        <location>
            <begin position="334"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT68715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="541" mass="59527" checksum="061B56108C9484BA" modified="2013-09-18" version="1">MAPHAEVGTGSSNGAVYNGRGSSATQDLFTVNSPNVTYTDAEIRSRYTYRTTKVDVDANGKYVATPNETLYDFKVDRKIPKVGMMLVGLGGNNGTTVTAGILANRRQLAWDTKEGPRESNYYGSVVMGSTLKLGHDAKTHQEINIPFHNILPMVHPNDLFIGGWDISKMNLAQAMDRAQVLEPTLKAQVKKEMAEMVPLPSIYYPDFIAANQEDRADNVLEGSKACWAHVEKIRQDIRDFKAKNGLDKVIIMWTANTERYADLIEGVNDTADNLLKAIEQGHEEVSPSTVFAVACILENAPFINGSPQNTFVPGAIELAEKHNAFIGGDDFKSGQTKMKSALVDFLINAGIKLTSIASYNHLGNNDGKNLSSQKQFRSKEISKSNVVDDMVEANHVLYKKGEHPDHCVVIKYMPAVADNKRALDEYYAEIFMGGHQTISLFNICEDSLLASPLIIDLVIIAEMMSRIQWKAVSSDGTATTEYKSFHSVLSVLSYMLKAPLTPPGTPVVNALAKQRAALTNIFRACVGLEPESDMTLEHKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2R8</accession>
    <name>S0E2R8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431171.1">
        <property type="nucleotide sequence ID" value="XM_023578347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2R8"/>
    <dbReference type="GeneID" id="35401504"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08027"/>
    <dbReference type="HOGENOM" id="CLU_863425_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="322" mass="35123" checksum="1F43D3D26BDAB240" modified="2013-09-18" version="1">MDPLSITSASVALAAAVYKCTIADATDSLSDLAEEAQLIQGALQVVEDALRTIMSLTLTTNLSKRSHELPRRELDTPAQESNVIIIKPVEDLIDLSCEPSEQATLMPPFIRPQSTDLIGLQFMPIASDDEVDSPSRLDVSQAAEPMNTRGITGYLRESSLPPEVHPAVAEASRIVLASDMVSDELLDGSPMGSSQAPNIEEFGLQKSLVDLEAKHGHAQRRRASPRGSAEISDEMRKGSVTTKTKHGQKITLQSQTKRPQQKHRFHKVNPGTPPDEKGPMLLKTVEDAIQRLIVPELNAKNEKAQLGRRFTGAEVSRYMSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2V0</accession>
    <name>S0E2V0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to KAP122 Member of the karyopherin-beta family, nuclear import</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431085.1">
        <property type="nucleotide sequence ID" value="XM_023578248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2V0"/>
    <dbReference type="STRING" id="1279085.S0E2V0"/>
    <dbReference type="GeneID" id="35401416"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07939"/>
    <dbReference type="HOGENOM" id="CLU_005271_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040520">
        <property type="entry name" value="Importin_rep_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18806">
        <property type="entry name" value="Importin_rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="999" mass="110918" checksum="DEEAB8A711A8F039" modified="2013-09-18" version="1">MAEDPAEVERLILSLYQPNPPEVIAQTQATLSRLQGTPEAWGLARILLEKPDQQVRFFGALTIVIKLNNESSSLSPEDASELLLLLINHYLDTLRSRSSPLVARKLASALATFYINFHQLWSRFIRHLIFCLVSGQSCLPSALDEGPDTVSLMERMEPSQAQAALWVLTNIFDEVAKINLNSVQNIGIYGSILENSSDAVALMSRSMSPQTTTEEAHEDSIRCLQSWVWFAQKSSSKDTRLSEPIGPLITAVITSLTVYQLYSVSVELMVDLLSNCLMFLSDTHFDHLAQLFDSSWSQRRYEKLAQGDFEFDSLQYGLLLLAFGEAKIERFMQSGDDRSEKLLSNLCGLLAARGYVIEEDKIFVPALEFWLTYAETLTDLTYSDEESTGTWVPRARSHLLQAVSNAWQKIIYPPAEEFHSWDSSERISFHDARKDVVDLLQSVFTLVGPQLVSTFADFVLKSLSDSSWPQLEAAAFCLGGLADCISETDRGDDALSVVFKSSLFAILRSGQSEIPPKVQQTCVSLIARYTEYFERNVSELHPVLNFIFGVVGEHAMANAAAKSIHRLCGSCRGYLHTEANSFLNEYQSLVSGRRLDCGASEKVVGGIASVIQAMPDSNQKYLACGRLLEFVQTDVQHSLDLLRSYDGSPMPCCAVYTCSYAAPDETPALHTALKSLRCLASIGKGLQAPAELSIDLESSRASTRVVDPHLAQLQGSIMSMISQIQEAFNTSGEVVELICNVLRSGFSESEPGPFVLPPQSVAQYLTNQNLQTPRVGLLVKTACSFVSSLEHDGLENQQDMLNSVLLWVIGLLKQLPNYEVDTELTQNGIDFVTRLLNKRPITLLRLQPSDAAEFFFLFTLQVLDGKEPLPKASAAEFWATFVSIKYESQELNDVAQQAMQMLGPLLSRTLARNLGGNASRSELDKLSEPLKKLVYRYPMAKSWLEAGLTHETFPSTKVSPQDKSMFLKKIISLRGAKATNQVVRDFWQSARGSNFAYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4D6</accession>
    <name>S0E4D6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429649.1">
        <property type="nucleotide sequence ID" value="XM_023576744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4D6"/>
    <dbReference type="STRING" id="1279085.S0E4D6"/>
    <dbReference type="GeneID" id="35407842"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14391"/>
    <dbReference type="HOGENOM" id="CLU_031975_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="602" mass="66373" checksum="5AFA92A97E1F6317" modified="2013-09-18" version="1">MATRERPSNTCLRCAEIKQRCKGGVPCDRCSRLSLPCRPKGYSASLSGEFGLDGRDGVSVGQPKAKIRRVQTGCLTCKRRKKKCDERKPSCGDCRRLCLDCSWPTERASRPRLNGWTNESWLSAEQVLDLSSETSPSPNPSPGSVQSNVDLSIADLLCQMSTAVPVDGADVDITATLPELSWDLTTDTGWLDILPETPPIAEDSPDSLPNTTLTLYTPSLVPDMTSPHDKALLNHYSNIVASVLSRHPNSTSNPYLSYLVPMAVSNQLILHCVLALSATHWQKLQPDMRDRALYHKGQATQSLAGLLPHVDGGSVDVALVSCLLLCMSELFDGTSAGWKLHLQGAKRLLSTVKSQTGGNLTGHFKFFVKLARFLDSAATTSTCKPPLIDDKTVATTPEPTEDASNDDAAVYGIPKELFHMVDRVNNLASKRGTRVDEASEALFREEAERVQGRLDNWAYDYGGLAGAVASLSPTNDDVLHATTAYEWALRLRLHQITEGYSLTEKVFECVQHILDSAQKIRYGSPLESCLLFPLVMAGGACNCLEQRMVVQDRLMIMERTCGFGYVHQSRELVETVWKRRETESMVNWARIRYEEMGGLALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4E0</accession>
    <name>S0E4E0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431834.1">
        <property type="nucleotide sequence ID" value="XM_023578901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4E0"/>
    <dbReference type="STRING" id="1279085.S0E4E0"/>
    <dbReference type="GeneID" id="35399143"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05664"/>
    <dbReference type="HOGENOM" id="CLU_016575_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="72608" checksum="86D4085CD722B1FB" modified="2013-09-18" version="1">MDFAGGLSSDEIRRIDRIMDLEWMEFAEGWEWHALNYVNPLPPMIPYPSYCVSRRCGWCRFSIKPGDLITARASGGTETVAFESCDSFNDEKLHATFRRCTSDHESCATIGYHVECSEIASSFGLDKRAFVQVARYSYEPSVQQDERRREWILNHLHQIMSEKFASLPPEILLMICKNLVLHYAIASLSHVSRSIQCTIEPLKDVWATHFDLDGIEYTTSLSNMPKPGSSLLWREVEGQQENYLFISEDHLGIRQIVNDPGAVTSVQGSSGWWRTLPITSKVLSFSDDGLKLRSFAAAPLNPTICWPYPMTPNAMKNMAYHVTKDSSSSLGMTIEAQMVALEFNEPEITGYSACWYKDQLVDLHTHKAEESLAFYRELDEMAKQKLAKEKSDDSTTSSSPHWTYHPLNLGERVEQVWLRSRKEASEKDTTEDERRPKTSDTATEAAILLVTNQSRTLTIGRSSSPRSEWKCIAKESMENPMIVYFSPRLGGISLFASPTVKGSDKETLPARLAHESETDLVQTSEVSLDAVREVQICREQSEKVNSSISGLLFLYKDGSQACMGKFRFDHAKEIVSVADSTRFYLGTRYLDQGNQVLREFCLSKPEYEDEPLEWKSTLWKGSLPREIMLLMGNQMGLLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6B8</accession>
    <name>S0E6B8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431362.1">
        <property type="nucleotide sequence ID" value="XM_023578146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6B8"/>
    <dbReference type="STRING" id="1279085.S0E6B8"/>
    <dbReference type="GeneID" id="35401324"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07847"/>
    <dbReference type="HOGENOM" id="CLU_008909_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="4">
        <location>
            <begin position="503"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="805"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="827" mass="92958" checksum="A267543DB27421FB" modified="2013-09-18" version="1">MDTLHARADWESVGDRWFRKTQQYTAVFDQDLDLDNYIVAGAPYAGALALWRDDTKLLAYQPGRSAKPAIDIYSLAGKKLRSIPWDNGTIKGLGWSEDETLLIVTTDGTVRCYDLQGDFTQFSLGHGADNYSVESCRFYDHGMVALLGNNSLVTVSSYTEPRPKALAKIPESEIHAWSIISPNHTLSRSVEVLLSVDKTVYVVDATDCEDRFLDIGPFSHISVSPDGRYVNLYAVNGKAHVISSDFQERLFEHDSDSQTPPLYVEWCGSDALIAWEDEVHIIGPGDSSSSYIYDSTRVHVISEHDGARLITNDFCEFLERVPRDTIEVFGQASDSSPASILLDAVGQLELESPKADDYIQLIRPNLTGAVDTCVNAAGREFDTHWQKRLLKAASFGKSVLDIYNSDDFVDMCETLRVLNAVRYYEVGMPLSFEQYHRLTPESLIRRLLNRHEYLLALKIAGYLKLPTDRIYVHWASSKVRVGGEDDDTICRLIVERLSGKPGISFEEIARAAYQEGRGRLATELLNHEPRGGRQVPLLLSMEEDELALDKAVESGDTDLILSVLLQLKKKLPLAAFFRVINARPTATALVEALAMEEGDNTLLKDLYYQDDRREDGANVFIRESLKQPDARTASDKLALAAKLLADSKESTFEVHALKEATTLLRMHEAFDRDLTDTFTGLSVNETMFKLIRLGYHGRAKKIQSEFKVPEKVAWWIRLRALVAKRDWNEIEEISKTRRSPIGWEPFFNLTLQAGNPRLASVFVPKCTSVEAGETITMYEKCGMRVKAAQEAVRLKDSESWERLLEAAGKGSQEGREIERLGQSVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6Y0</accession>
    <name>S0E6Y0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable G protein alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_06643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432733.1">
        <property type="nucleotide sequence ID" value="XM_023579991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6Y0"/>
    <dbReference type="STRING" id="1279085.S0E6Y0"/>
    <dbReference type="GeneID" id="35400120"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06643"/>
    <dbReference type="HOGENOM" id="CLU_051043_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT70654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="443" mass="50886" checksum="A89DF5D4E0A51C9C" modified="2013-09-18" version="1">MDCDKESNHVNISGIDEDSLKHPKPDTSRGAGSRRTRAESKPARWWEGLCPLFSKTMQSLEPPSAREEDCLSLPSYPAEAKARTRAIDQYLAAEFQRSKRQLKIILFGDEHEKSLFLKQARLLEVPLSNEDRADVRAEARRFVASICRECLHIVDEHACKPEWINAHPVLGRVKEIVSSEEPEDEETVESMVNLYCDAELRLALMQFGHNFNDIERRFLNSRYPHILTCPCTANGNLSKLLKRIFAPEYVPTEHDWFHFDQRRSGRVAQEALIHRDSHTLQLLQITDRSTQRRKWIHVLVDDAACLLFICNLAIYDQTLLEDETINRLHEDLILFSSLANSRWFAQTPFLVILSNISAFRNKILQSPLSKWFPQFEGGSDGDAALDFIGDRFRELAKADQNMYIHATDIDSAEGVIAAIETMEYRSLGKVFEEIHMPPAKHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E733</accession>
    <name>S0E733_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432730.1">
        <property type="nucleotide sequence ID" value="XM_023579988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E733"/>
    <dbReference type="STRING" id="1279085.S0E733"/>
    <dbReference type="GeneID" id="35400117"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06640"/>
    <dbReference type="HOGENOM" id="CLU_969930_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32329" checksum="D7659A920523ACD7" modified="2013-09-18" version="1">MTETTRQLQHDLVRLGFSHHYLLNSILGLTALQLYSEDRSKSRWYARAVAHQQAAITRARPHFESLTQAHGQALLGFSAFTSMYAVAEPIYRPSGICSESPFDPVEELLKALRFSRSTIMFVQQSFPPAVISGSWLLTKFSTKYKDTENDLETRYPQLAFLQRCITSHVQGVHMRACLQAVRALFRRIATLSDNVGDPEPAKIVWGWGLEVSQIFLDLCSVRHPAALVILGHFAVLMSYNKHWCLSPWPAGLLSYINGVLGSEWEHIMKWPGSVVFGGNLAINRLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E768</accession>
    <name>S0E768_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_05474</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431657.1">
        <property type="nucleotide sequence ID" value="XM_023578689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E768"/>
    <dbReference type="STRING" id="1279085.S0E768"/>
    <dbReference type="GeneID" id="35398953"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05474"/>
    <dbReference type="HOGENOM" id="CLU_076372_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="66"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT69577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="241" mass="27261" checksum="CD7029FC7895F167" modified="2013-09-18" version="1">MSSTIIQHAGSSLEEQPLLQRGKRRLPSLNIQHWHSHPFRGDEWSVRSTKQKTAQFLSSKAGHYSVLMLVSLDVLSMIADFILNLFKCEQGKKGSDWDLALEILGSISLVFSCLFVVELIASVWAFGWRLVLSLSHPDLMADLSRYFNSWFHCFDAFIVIAGFITDVALRGIIEEVASLIVVMRLWRVVKIIEELGVGAQEQTEELNVKLEKVESENEDLRCEISRLKGAMKKAGLDQQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7I6</accession>
    <name>S0E7I6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_05639</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-methyl-UTP(out) + UTP(in) = 5-methyl-UTP(in) + UTP(out)</text>
            <dbReference type="Rhea" id="RHEA:73523"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:63527"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431812.1">
        <property type="nucleotide sequence ID" value="XM_023578873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7I6"/>
    <dbReference type="STRING" id="1279085.S0E7I6"/>
    <dbReference type="GeneID" id="35399118"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05639"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000088">
        <property type="entry name" value="Mitochondrial carrier protein RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="57"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="177"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="291"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT69732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="385" mass="42652" checksum="165E00E0F9B5777B" modified="2013-09-18" version="1">MSHHQPASHAMSSRDEKPFHHSHSPIDHSALIQSRETGDVIPDDTPIQGNVKALPFAKSWVHMFAGGVGGMTAAAVTAPLDVLKTRLQSDFYQAQIRAQREAQAQVIGRLNPARAALYHLNDTLQILGSVYRNEGWRALFKGLGPTSVGVVPARSINFYVYGNGKRLISEHFNNGVEAPWVHLSAGVAAGVITSTATNPIWMIKTRLQLDKNVAAGGAQMRKYRNSYDCIRQIIRDEGIRSLYRGMSASYLGVVESTMQWMLYEQMKASLARRHNTIVRSGRELNWWDKTVDWTGKGFAAGSAKLVAAVIAYPHEVARTRLRQAPMENGLPKYTGLVQCFKLVWLEEGVMGLYGGLTPHLMRTVPSAAIMFAMYEGILRLFHTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7N0</accession>
    <name>S0E7N0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT70909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432988.1">
        <property type="nucleotide sequence ID" value="XM_023580163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7N0"/>
    <dbReference type="GeneID" id="35402541"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09067"/>
    <dbReference type="HOGENOM" id="CLU_2306379_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="100" mass="10939" checksum="914F996FA8184039" modified="2013-09-18" version="1">MSNLYILNIINQSGEEADYSIDCVYEDIPPVTIRDRDNWMTVLNLNQHYIPITVSVLPQGDSPSVSFVLAKNGQGVRGDVVHSPGDQLTIDVGNNIGTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8N7</accession>
    <name>S0E8N7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432226.1">
        <property type="nucleotide sequence ID" value="XM_023579380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8N7"/>
    <dbReference type="GeneID" id="35399571"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06094"/>
    <dbReference type="HOGENOM" id="CLU_1366349_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485387" evidence="2">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="200" mass="22115" checksum="F3FB99A9046F4D2F" modified="2013-09-18" version="1">MTRIGGCCAASVWALGSGLWAQTPLNSRLHATTSPEPTLHKVDPTATTAAATVQVHVNLSPLPSSLLLFLFILSFIIPVTQRSKNYHYIDPRITASAVLFGIATLRTENITLLLGAHQLHRVASDVPPRVQTLSFILTLTDITTDSYPANLRDDRTYTHSFLTTRNATLYHTCIGISNIYLRNPHQTVHLCGRNPRHRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8T8</accession>
    <name>S0E8T8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_08623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433395.1">
        <property type="nucleotide sequence ID" value="XM_023580654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8T8"/>
    <dbReference type="STRING" id="1279085.S0E8T8"/>
    <dbReference type="GeneID" id="35402099"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08623"/>
    <dbReference type="HOGENOM" id="CLU_070952_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="48"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT71316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="173" mass="20000" checksum="FDA42814AAAC2D65" modified="2013-09-18" version="1">MRPGIRNTVERLDRPSAYYQNRNKRRRDRDDDQDQPSEPQADPLANATTLYVGNLSFYTTEEQVYELFAKCGEIKRLIMGLDRFNKTPCGFCFVEYYTHQDALDCLKYIGGTKLDERVIRTDLDPGFEEGRQFGRGKSGGQVRDEYREDFDEGRGGVGRAIQAEERDEYAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9A0</accession>
    <name>S0E9A0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433319.1">
        <property type="nucleotide sequence ID" value="XM_023580563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9A0"/>
    <dbReference type="GeneID" id="35402182"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08706"/>
    <dbReference type="HOGENOM" id="CLU_702161_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="463" mass="51498" checksum="6D0B8ECF8069C2C7" modified="2013-09-18" version="1">MPDAAQQLLSARTAQRIHEQVTREVFRLAGRDPDHHMECFKACLKTIEDTKVVEATDYAIWQSQEPIASPLREFYNTNRTTKSGNFYMLPATTAVAIAAILNLKHVVINSNGNTKHIVSSVSETAVWAYLGIAIDVWPQTSESQFFIKKSDEGSKSPTVGRFARGKFAVTTNIPGETITSLMLLTMARFNGWIKSVPGAPCLKKGTVDAPQIIHRRQALSQGKEILEKLGNRKYKQNDPALIREVKAWLSEPIILAKSWLPIIKDADTDLSVYKFMGKTGATLASLVSDEIDYIQLAQQVNDSESTAAKPGCQSFQQVFGPPWNECLLNQEADGTKNIIVGALQRLFDNIAYVVPRTHSLYGAFLDMASKMDIAVMSSLDLDLVRAKDRHQKRLNINDDLLYRNEIMTNVAEAIGRLERGSASQERLLRSKLCSILDAADALILKENLPRDISIVISANNHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9C4</accession>
    <name>S0E9C4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to micromolar calcium activated neutral protease 1 (Capn1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_07977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431123.1">
        <property type="nucleotide sequence ID" value="XM_023578290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9C4"/>
    <dbReference type="STRING" id="1279085.S0E9C4"/>
    <dbReference type="GeneID" id="35401454"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07977"/>
    <dbReference type="HOGENOM" id="CLU_006072_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000072">
        <property type="entry name" value="Cysteine proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="147"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT69043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="906" mass="102592" checksum="F9C0A3308524B16C" modified="2013-09-18" version="1">MPSSSSSSSSSASPSFAEIASGVADLGDRSKVTPQQAIDKFWKQFTTKNPGKATTVIPSNTYTDLAAKRGNQVTTTTTLASYEDAAATCRAKVEKIVKECRRINKKYRDPHFDIEVDLKLYRNDCLHSLSNVENYQPGEDLRPQSVKRVGDIFEKPCFYIDGPTANDVRQGRDGDCWLMAALCTLSEKPGLIERLCVAHDQDVGVYGFVFYRDGAWISEIVDDFLYLIKPDYDEGYFDRILFDDVERVDPDEAYRRIFQSNSSALYFAQCQHPQETWLPLLEKCYAKAHGDYGAIEGGFGGEGIEDLTGGVTSELLTTDILDKEYFWKEELLKVNQEFLFGCNTGIWGRGWGERKGIVELHAYSIQKAIEIDGKRLLKLKNPWGKGEWTGPWSDGSKEWTAEWLQKLDHRFGDDGDFWISYEDLLRKYQAFERTRLFTDDWRVSQLWTTLSVPWALDYHDTHFSFTLSKPGPVVLVLAQLDDRYFRGLEGQYMFELGFRLHKAGHSDYVVRSQTPYRMTRSVNVELELEAGDYEVRVKINATRNQDILPIEKVIKDNAKSRREKLLRIGLAYDLGHCKGRFVETPEEKAARKEHEAKIKQKKRDKIKAKLLKEREEAHYLATRQFERDEHKRLKRKEKLALKKAAKKARQEARKAERAAIKAEKAAKKAAEAEAKAKLEAEEAAKKEKEEETEAAKEEKAEGDEEKVESKPEEPMTPESTADEDSNEKEEAKEAEAAEPKADEKEAEADAEEEEEEQDIESEPETDVESVGTLANLADRELWIHVDNYTGTISSDSDSDNESTTSSSSSASEAEKDPWNAVVVAGIRIFHTGLGEGEDDSDINLKVIRPIPFGKDDEEVDVEKKCSTKVLDVDDSAKDATLVGDASEKIRFIKGDGAKRRTATSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA66</accession>
    <name>S0EA66_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_08398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433599.1">
        <property type="nucleotide sequence ID" value="XM_023580907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA66"/>
    <dbReference type="STRING" id="1279085.S0EA66"/>
    <dbReference type="GeneID" id="35401874"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08398"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT71520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="147" mass="16536" checksum="5DDEA7925B669C54" modified="2013-09-18" version="1">MALKRINKELTDLGRDPPSSCSAGPVGEDLFHWQATIMGPSDSPYSGGVFFLAIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRPRYEATAREWTRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAB7</accession>
    <name>S0EAB7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to potassium channel beta subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432781.1">
        <property type="nucleotide sequence ID" value="XM_023580049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAB7"/>
    <dbReference type="STRING" id="1279085.S0EAB7"/>
    <dbReference type="GeneID" id="35400172"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06695"/>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="336" mass="38745" checksum="98DC30211ECB9A17" modified="2013-09-18" version="1">MPQTQKARVPVIFGAMTFGREGVEQARIHDLKEAGAMLDLFQEHGGTAIDTARVYAQGSSEEYLGQLDWQTRGFRVDTKLYPNIHDGTGKITHSADDLRKHLDESLKALKTDKIDLWYLHGPDRDTPFEETLRACNELHKEGKFNRLGVSNYMAWEVAYMSELCIREGWIRPTVYQGVYNAIHRTVEMELFPCLRHYGITFYAFSPLAGSQLTGRYKRDTQDTDIESMSRFDPNTFQGRKYRRRFWNDVIFDAVELIRDEAGKHGLTEMDCAFRWIEHHSQLDPERGDAVIIGASSKKQLEQNLDLLEKGPLPKEIVDVLDKAWLITKGSVNNYWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAG2</accession>
    <name>S0EAG2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to HSD1 ER membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433979.1">
        <property type="nucleotide sequence ID" value="XM_023581014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAG2"/>
    <dbReference type="STRING" id="1279085.S0EAG2"/>
    <dbReference type="GeneID" id="35401777"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08301"/>
    <dbReference type="HOGENOM" id="CLU_031477_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="603" mass="66741" checksum="F9AC7D488265294F" modified="2013-09-18" version="1">MARTTCVRAPVTATVINTLYLRTHHAAGDPTSVAPLLINLDSINTLDSHHSLKSRPKRSPSPPNRNSSQSLSPSQGYGQNQQLHHHHHHHHQQQNLGLEHNGQGLRHIYLRHSHDHDDHEQHLLDLGKKQYNIPTNGSSHYDTPNTFTISSPSEPITTVRSSRRDKHLHSTIPNTFWPSGFNALSRIVVGAVRCSALPPFSLTMSFRSKIPETPRVISPSPTPSERDAADYIGPVTRSAARRRTPTPQPLEEEPDEDLPEPPEFRRARTRSRSPIDTQAVTRLTRRTSTAAKAGKMSKDTIPEEQTTSNGALSSNGNGKSTTSNGHLAPPQPSTPVGWSWRDFSRSPSPLGLIPIHRHWRTFVHKHEVPRKVLHVSIGFFVIWLYVTGTQTTSVTPWLMSALIPIAATDWLRHRYASVNRLYVKVLGALMRESEYSGWNGVIFYLLGAWIVLYGFPKDVGIMSVLLLSWCDTAASTFGRLWGRYTPRLRRGKSLAGSTAAFLVGVGTSYFFYGWLVPTVGPFPGDENFLFKGVLSLPKTICEAVGVSKEQTTISGALALGVMGIWSGFVASASEVVDIFGWDDNLTIPVLSGLGIWGFLKIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB12</accession>
    <name>S0EB12_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to beta transducin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_13901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434179.1">
        <property type="nucleotide sequence ID" value="XM_023581487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB12"/>
    <dbReference type="GeneID" id="35407355"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13901"/>
    <dbReference type="HOGENOM" id="CLU_024750_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="402" mass="43286" checksum="120CDEBA8F877769" modified="2013-09-18" version="1">MSGDNGGVAAQADILGIPGAALNTIGFAQGLLRAVSADNANPNAVIQVQQIGSCFQSNGPWAAKIPDLLSRASCVRLERLSAWVGWAKDDTPAFMSQTTGGQTAALLCCALGSLYSKSRCGLLLYDLCRDILPADRQLSSPTQLGDVCMLLERKSACLGFGNHLALQVTRLRQCFFEAGLDVPRDLADTPTEEDLNHFLSGVCSALQDESLVLQVSGTRCVGTLLALTLAMCPEDVSVRINREVLMSGLRDNIIFSVTTEDGSSTQIHLETKLEIKKAGFLKRHIITESQHIHNQELRFVCDGILSSQLDISLSMAGVESSQLLKLAISNFVASIAMEPATDCLSSKAAYGLGDCFPTQGFRVILGPTYRQTISQRLEKVLCCPSDTLQSPKEAFNRLQNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBH2</accession>
    <name>S0EBH2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434369.1">
        <property type="nucleotide sequence ID" value="XM_023581714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBH2"/>
    <dbReference type="STRING" id="1279085.S0EBH2"/>
    <dbReference type="GeneID" id="35405599"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12143"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07144">
        <property type="entry name" value="ALDH_ALD2-YMR170C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT72291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="495" mass="53642" checksum="3F8C2A7EADCC194B" modified="2013-09-18" version="1">MASTTSITLPNGKKYDQPTGLFINNEYVAASGDEFTVTNPVTEEEVIKLKGASKEDVDKAVQVARKAFEGEWSELAAVDRGAFLYKLADLIDRDRELIAAIDAFDNGKPFSTCLAGDLDESYNVFRYYAGAADKISGKTIETSPAKLAYVLQEPLGVCGQIIPWNFPFMMLAWKVAPALACGNTVILKPAEQTPLSALYFGNLVKEAGLPAGVVNVLPGLGPQTGKAIAGHMDIDKVAFTGSTNTGRAIMKDAANNLKNITLECGGKSPSIVFADAELEQAVKWCHFGIMDNKGEVCTSTSRIYVHEDIYDKFLEKFVAVTKENDKLGSPFEEATVQGPQVSKTQFDRVISYIEEGRKSGARLLYGGSKHGDKGYYLQPTVFADTTEDMKIMKEEIFGPVVSIAKFSTDEEAIAKANDTSYGLAAALFTEKISRAHKVARKLQAGMVWINSSGDSHFGIPFGGYKSSGIGRELGQYALDAYTQSKAIHVNLGFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBY3</accession>
    <name>S0EBY3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Related to BCS1-mitochondrial protein of the AAA family of ATPases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_12331</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434534.1">
        <property type="nucleotide sequence ID" value="XM_023581925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBY3"/>
    <dbReference type="STRING" id="1279085.S0EBY3"/>
    <dbReference type="GeneID" id="35405787"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12331"/>
    <dbReference type="HOGENOM" id="CLU_010189_4_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="46"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="261"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT72456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="485" mass="54913" checksum="3F58F5B048575619" modified="2013-09-18" version="1">MSHHFHVGAATGQHLLDPMSQGIGIMRDVVSRWSELDITQIGSLIAIAGTVPTAWRFLHRIWHEVYGTIRRFFLASVTIPGGDPLNRSVVKWILANRERHYRSFHGRTDIGQNGDRAAALKKTKHSIQYSPHWNTRWLFYEGNLFLVTRRIDDFSSSLSDPSYDGIGGEEITVSCFGWSAEPIKAFIESCREYSDRQTQFFVIIYARDRYGLSWKPKARKPIRHLETVHFDNETKQELLGDIRNYLDPKTQKRYQSRSMPYRRGYLFYGPPGTGKSSLSVAIAGEFGLDLYEVKIPSVATDADLEQMFQEIPPRCVVLLEDIDAVWTDRSNSDNGQEGSSAPNCTLSGLLNVLDGVGSVEGRIIIMTTNHPEQLDSALVRPGRVDMKVLLGNISRKSAEEMFIRMFSPDLGCTSHLDMDEIKKLAAEFGKEIPDDTFTPSLLQGFFQLHLESPQEAASSIGAWVKREFEKSSEKEFELITGKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC38</accession>
    <name>S0EC38_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434522.1">
        <property type="nucleotide sequence ID" value="XM_023581912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC38"/>
    <dbReference type="GeneID" id="35405775"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12319"/>
    <dbReference type="HOGENOM" id="CLU_1845262_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="139" mass="15910" checksum="A8969104889786E7" modified="2013-09-18" version="1">MGKCLSRPERHNILPKRLYPVNTLDNEQASMYSHPNVMLKTNKGARNTTPCAKATTSTKQSARKRHSRHRNRETRQMKRNLKDIRVRLDHARARYEAAKDEVASCEKEITNLSQRMNGRRGLAAVQPDTESRAGISDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC70</accession>
    <name>S0EC70_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine-rich cell wall structural protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433486.1">
        <property type="nucleotide sequence ID" value="XM_023580766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC70"/>
    <dbReference type="STRING" id="1279085.S0EC70"/>
    <dbReference type="GeneID" id="35401999"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08523"/>
    <dbReference type="HOGENOM" id="CLU_056606_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="27908" checksum="F45FFE036330616A" modified="2013-09-18" version="1">METISNLTAAASKAVWGDNQTANKEPVSGVQGDTRQGEPYDAGNLETPQQEKVAQTFGSHGEERATGLGHEAPVSKPTDATNAASATPSVPAPNPHSKDTSAGQNDTRDPAQADKGNKDLHDVDDTSEGTDVKLGEGPGPQPIEKLAKEHGGDAGNAPVEGTSHKPTEVGSEGATESSKSENQPHDPKEDEYVTASGFAADGGDFDASKPGAGREADRLLEQKGIHLGESGGSDHSKTESHSGGKHHGSDEKKDKPSIGERIKAKLHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECI9</accession>
    <name>S0ECI9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434749.1">
        <property type="nucleotide sequence ID" value="XM_023582179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECI9"/>
    <dbReference type="STRING" id="1279085.S0ECI9"/>
    <dbReference type="GeneID" id="35406015"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12559"/>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="330" mass="37855" checksum="9464428A220B1038" modified="2013-09-18" version="1">MTTIEAHPVVDADDSHSDADSSLGADNASSTDSLRSSILDFRQENGRTYHAFRDGKYNLPNDDEENERLDLQHNLFLLTLDNKLGLSPPNLPDSKVKRVLDVGTGTGIWAIDFGDEHPEATVIGVDLSPSQPSFVPPNVRFEIDDIDEEWTYSEPFDFIHSRFMNFSIQNWKSYFTKIYQNLAPGGYVELQDVDVIMGSDDGTLKEDHTMYKWCRLLDEAAGKFNRSFERTTNFKDMLKEVGFVDIVETRYKWPTNHWPKDKKYKELGQWNNVNAASALEALTMAPFTRGLGWSREEVEVFLVQLRQDWNNPKIHAYWPICVTYAKKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECT5</accession>
    <name>S0ECT5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434513.1">
        <property type="nucleotide sequence ID" value="XM_023581899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECT5"/>
    <dbReference type="STRING" id="1279085.S0ECT5"/>
    <dbReference type="GeneID" id="35405764"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12308"/>
    <dbReference type="HOGENOM" id="CLU_012494_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="103"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="386" mass="43183" checksum="2A2172AF2FE08D7A" modified="2013-09-18" version="1">METEFTPSESRPTTPEPPGYVNPLESSSRWYLIARAQAIRSAASLGFSIANRTDPPAPSPTKDIWLDATLSKADLSRADRAKTKIKAEVWMPPRPALGARAAVINFHGGGWILGQGTDDARWAGAIMANLDAVVFTVNYRLAPSCPFPTPIEDCVDAVLQIKHRAAEFGIDPDRIILSGFSAGATNALASWLILNDPDRWGYKFPIEPPKIAGITLYYPLLDWTISRPEKRLTCSKPEFTLPKGLTDLIDASFIYPIIPREERCDPRLSPGLMPDELLKKLPPIHLVLCEYDMLLAEGLKFSNRLKAANKKFTLRIVEGERHAWDCPPPMSPKESVAIEYQEAVETMASWFGQKCETDTESMRSMRLKRPVLKRPKYLSFKTWSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED20</accession>
    <name>S0ED20_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434857.1">
        <property type="nucleotide sequence ID" value="XM_023582306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED20"/>
    <dbReference type="STRING" id="1279085.S0ED20"/>
    <dbReference type="GeneID" id="35406128"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12672"/>
    <dbReference type="HOGENOM" id="CLU_011527_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="549" mass="62127" checksum="98B76A29DF2BE2EB" modified="2013-09-18" version="1">MSTPYPFDLGLYKRTISTTSPESQAWFSRGLIWAYAFNHEESVFCFEQAAISDPDCAMAYWGLAYSLGPNYNKPWSFFDDKDLADAVERGHNAARTAMAKMSACTPVEQALITALQHRYPQERPSNCSSWNQGFADAMEGAHRDFPDDLDVITLYADALMNLNPWNLWDLKTGDPTPGAHTLKIKTIIDNGLKLNGSLEHPGLLHLYIHLMEMSPRPEDALATANHLRGLVPDGGHLHHMPTHLDVLCGHYQAAIDSNSEAIKADDKYLSKAGPLNFYSLYRCHDLHFRVYAAMLAGQYKVCIDTASQLESTIPKDLLQIESPPMADWLEAFLSLRAHILVRFGKWQDLIDMEPPEDQDLYCMTTSIVLYAKSVAFAATGRVPESEHHKGLFHESLKRVPTSRTLFNNTCLDILRVGEAMLDGELEYRRKNYDVAFEHLREAIRREDNLPYDEPWGWMQPTRHAYGALLMEQGYLEEAVEVYKTDLGLNDKLPRALRHPNNVWALHGLHESLTKLGRDTETKEIEGDLQKALAGTDVLVKASCYCRLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDN3</accession>
    <name>S0EDN3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432582.1">
        <property type="nucleotide sequence ID" value="XM_023579812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDN3"/>
    <dbReference type="STRING" id="1279085.S0EDN3"/>
    <dbReference type="GeneID" id="35399959"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06482"/>
    <dbReference type="HOGENOM" id="CLU_041813_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54205" checksum="4DB06881F840C8E1" modified="2013-09-18" version="1">MPPTKRKAANALDPSERKRAQNRISQQCLREKNITYIRNLEETIELLQKVATGSDPQDRYSVLLDAHLKLISENRKLEDASLRLRKKLLSFGQAATAAADDEVFDSIFRRRDAGNPEAQQSAPRMDLANHETPPALNPSVNNQSFQDIPEQVTHTDIFKDASFLLDLSTASQVQHETLTPSTMQPGDTFLDPAMSSLSPRSLLFVPNQLSITSMSIFGSRLLDACRRHLDNLRDAGNHSDMVEKIIKTAVRFSMRCAGLESYAYGVNGAKYIERVISWRLGIESRNSVPLPFRPTPLQSKNPTHFWGIDLFNWPEIRDQLVLEAETTDFDELIKDLVLHSVIEPANHSVAVNVLDIFQNQVLRRRQHQKSSARSYFTDPSWTLFQIGPEVGEWYSSEHDIVEEAIFQELDRQINAVAPSPEDNSVEDSRANDVAKFLGLDDFCEWKLSKEFARKYPKLDCSTAVTQRDLAPSAMVYCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDX6</accession>
    <name>S0EDX6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to monophenol monooxygenase (Tyrosinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_06591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432682.1">
        <property type="nucleotide sequence ID" value="XM_023579933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDX6"/>
    <dbReference type="STRING" id="1279085.S0EDX6"/>
    <dbReference type="GeneID" id="35400068"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06591"/>
    <dbReference type="HOGENOM" id="CLU_035914_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495878" evidence="3">
        <location>
            <begin position="21"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT70603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="382" mass="41896" checksum="FE3C8F73AC1DEAC1" modified="2013-09-18" version="1">MQLSYTILAALLGASSLVAASPTQSAGDLLLELNSKATNALENAQAPSSRKKCTITNADVRRDWKALSKKEKKAYINAVLCLRKKPSKAHPSFAPGARTRYDDFVAVHINQTRTIHATGNFFTWHRYYTWAYEKALRDECGYKGTQPYWNWFETGDFATNPLFDGSETSMSGDGEFFKHNGSVSGQGTIFLPSGDGGGCVKNGPFAGATANLGPPSPGMDGMEATTTPLEYNPRCLRRDLGRYAIDKWMTLPNLYNVTLGDASRSIQIMQDEFQGRFPDRFLGLHGAGHFAIGGDSSDLYSSSNEPVFFLHHAMVDRVYWIWQALHPKQARDIAGTITIGNRPPSRDALTSDPLNMGVNAAEITIDDALDTLGGSPLCYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEM0</accession>
    <name>S0EEM0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432927.1">
        <property type="nucleotide sequence ID" value="XM_023580089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEM0"/>
    <dbReference type="STRING" id="1279085.S0EEM0"/>
    <dbReference type="GeneID" id="35402607"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09133"/>
    <dbReference type="HOGENOM" id="CLU_477373_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="633" mass="71124" checksum="2C8E2ECEC5658B03" modified="2013-09-18" version="1">MLYQTAMKASASIYTLFVTAALFAGILIVHTELELMAGHNSYPWLQLTQPLEGGEGSESDMSFTTSTMSPEPFTAQHSMASLADLEFEPGFSTPIPPFPSHDARAHTLSFAEEFHLTKKVDNGTETTKLDAETQPQYCSLDMLSNNTFSLRQLSVKEADGFTSFDASETNGYYEQNPVDQVADFTFLDASENCEHYGRVQDSTESLLSRKMFGPSSTSMSRCGNGHNFEPLESIIEDLPSFREKSIPLDLNETCIDDGDGSPCPSMIESDDSSVEDIGLRKAFACPYFRLDPVRHIECLSRRLYRIQDIKQHLSRRHYIRRDKMSNASDNIQGINIKTQKILKLRSDRRLSPESQWREIWRTLFDRSLPREGPYLGNLKEEIVGSAITICKKGSSRVVPGIVRSLGLRNDQGKAIQQLMEHLFSGFQALSKEESNDVETEDTSTYSGVDSLPLTPKGMDFGFDVPLHRSPSPQIQASYSTEDIMQIEQFSSVMPTRLPDDTTFERNNENDILMEYQPTKHLKTDVQVKPVWSLHTALGTLKTVENSETACSTSNSKPDGKSLNCWTPVLDDRKDADIGMYEYVDAWECDNCGFEYIFRPSGTSSDMLCFNVLCLGRLPGHYDSVYKARVRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EES8</accession>
    <name>S0EES8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to LCB2-serine C-palmitoyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432967.1">
        <property type="nucleotide sequence ID" value="XM_023580140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EES8"/>
    <dbReference type="STRING" id="1279085.S0EES8"/>
    <dbReference type="GeneID" id="35402562"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09088"/>
    <dbReference type="HOGENOM" id="CLU_015846_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="31"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="401" mass="43689" checksum="7C4BB60F46131E4E" modified="2013-09-18" version="1">MSKLEEQLRARLLDREKRSQLRRLTTFPADNVDFSSNAYLSLSSVPEIRSAYHSLLENHAAPPPLLGSGGSRLLDGNSTLAENLERDIAAFHNADAGLLFNSGFDANVGLVSCLPQTGDVVVYDELIHASAHDGMRLSRAGRRVSFKHNCVYGEGGLDEVLSGIGGEKSVFILVEGVYSMDGDVAPLKEIVACVKSRLPTNGYIIVDEAHSTGIFGHQGRGLVCELGLEKEIFARLHTFGKAMSSFGAIVLCSPTTREYLINYARTLIYTTAMPFSCLASIGISYQYLQSGRADERLKHLWNLVSYTHKLLAEACSLSQSIRAEAAPKSPIIPVFTSQPRSLAQFCQERGFTVRPIVAPTVPKGSERVRICVHAGNTVAEVEGLVETIKLWVQVHEGSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGG5</accession>
    <name>S0EGG5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to low-affinity hexose transporter HXT3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_10131</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436169.1">
        <property type="nucleotide sequence ID" value="XM_023567891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGG5"/>
    <dbReference type="STRING" id="1279085.S0EGG5"/>
    <dbReference type="GeneID" id="35403597"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10131"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT74091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="531" mass="58562" checksum="761AF7ADA1F8E33C" modified="2013-09-18" version="1">MLGNKSFTVNGAACGAEALVLALITSLGGFLFGYDTGQISAMLLFRDYVDRFAQTDDDGTKYWVPAIQGILVSLMSIGCLIGALSGSYTADWYGRRWSLTIFVVIFLLGNVIQITAMYSWVHMMIGRLIAGLGVGALSIGVPMFQSECAPREIRGAVVSSYQLMICFGILISNIVNYGVREIEDNDASWRIVIAIEMAFSIPLGLGVLACPESPRWLAMREDWDGVRTSLARLRGMMSDVKNPIVEDNIQEMRILLEEERKVGQGSWLECFGVRNKGPKVLYRTLLGMAVQFFQQWTGANYFFYYGATIFESAGIDDPILVQLILGAINVGMTFFGIYSAEKFGRRWPLIIGGLWQTAWLLIFASVGTAIDPEGSSTSGIVMIVSACMFIASFAVSWGPLGWVVVGEVFPLRTRAKQASLATASNWLANFLISFLTPFADAGISYAFGYVFAGMNLIGTVIVYFFLYESKTLSLEHIDMMYCLPDLKAWESAKWTPPGYVSREKKDESYFEEMAAGKDAEKVVVHSDSGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH05</accession>
    <name>S0EH05_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436112.1">
        <property type="nucleotide sequence ID" value="XM_023568191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH05"/>
    <dbReference type="STRING" id="1279085.S0EH05"/>
    <dbReference type="GeneID" id="35403326"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09859"/>
    <dbReference type="HOGENOM" id="CLU_093937_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT74034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="145" mass="16317" checksum="73973486AAB1A41E" modified="2013-09-18" version="1">MSKKQEKLTQEEIWDDSALIDSWNEALQEYKKYHSIHAKGGSVRELEPQNQAEAEAEAESGSEQPQVTETEEIELESGAAEQNKEIPSSRNESKEPIASQGTPSFPVQTVLGSVQDESLKKLLMSWYYAGYYTGLYEGQQQAQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI15</accession>
    <name>S0EI15_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434091.1">
        <property type="nucleotide sequence ID" value="XM_023581385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI15"/>
    <dbReference type="STRING" id="1279085.S0EI15"/>
    <dbReference type="GeneID" id="35407446"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13992"/>
    <dbReference type="HOGENOM" id="CLU_040908_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485283" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="26"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="315" mass="34943" checksum="824468B58159E5F6" modified="2013-09-18" version="1">MRQSTLYPFLCLWGLAESIDLSSKRGLAYHGDDHKSDNELLISNNSEIAWYYTWSLWPNGQISSSLPFVPLIHGLDDASDSELESRLNGLPESSTHLLTFNEPDGETDTGGSAISAKDAARAYIEHIVPLRKAKRKWSISHPSVTGSPRGLEWLRDFNESCYDIDDDGCPTDFVAVHWYGDAGGLKNWLGSLREFYNETAPDARFWITEMALPKEDDDATLAMMNESLPYLDNNDDVQAYAWFGAFRKDDANEWTGDSVSLFDDDGGLTKLGAEYLGGEKKGFEEGMSGDSGGSFHAPSLGIMLVMILISLISLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIR7</accession>
    <name>S0EIR7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to aminotriazole resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_10974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436979.1">
        <property type="nucleotide sequence ID" value="XM_023569819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIR7"/>
    <dbReference type="GeneID" id="35404438"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10974"/>
    <dbReference type="HOGENOM" id="CLU_000960_27_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT74901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="518" mass="54903" checksum="9190EB5C9DDDF1EB" modified="2013-09-18" version="1">MATQTETLLEDMLPSTAEAQSYVDSPLNTVANSTPAASRLQKIAVTFQLSGVNFAASATNGLIVVGLPQMTADLSLPPSLAFWPSSVQGLATASTLLLAGALADVLGARSVDLLGCILSGALMLACGFVRAGEQLVALRALQGVALALHLSSSVALVTKTLARGRGRNFAFACLGLSQPLGFSFGLVLGGVLVETIGWRSGWFLYGGINLVLSVVGFWSLPKSEPLGTLQEVMQSVVTKIDWLGTLLASAFMALMSYFLAIISTDVYRIKEASSIVLLSLSLTALPLFIGWMHLQVKRDLPALIPNAFWRNHSFTTICVTIALSNAVINSLELFASLFFQEVQHLSALNAAIRILPSVVVGVALNFTTGLVVHRIPAIWLVVITSVLTAISPLLMAVIDPAWTYWTAAFFAQVLMPFSVDVLFTVGLIVVTETFSKDKQAVAGSVFNAASQFGNAMGLAVMQVISTLVSKQHAGSKPAEALLQGYKASFWTMFSFMVLCALIGGVGLRKAGKVGLKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIT1</accession>
    <name>S0EIT1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436994.1">
        <property type="nucleotide sequence ID" value="XM_023569836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIT1"/>
    <dbReference type="GeneID" id="35404454"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10990"/>
    <dbReference type="HOGENOM" id="CLU_092543_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="5">
        <location>
            <begin position="60"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT74916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="187" mass="21139" checksum="529FC03E196A5A45" modified="2013-09-18" version="1">MSNDKPRPPPAPPLPPAVPKKQSQASSFKPRVRRDPEDWFYQPPRHAAQADLFEPPTGPYFVYGTLMDPKMLADILGLKEKPTMRPAKIRGYARKLWGQYPAMQDGPRDAQVSGSVYHVQSVAHAKRLAQYETNNYRAKPCLIQYTDGKEPGEDSGHVFMFVGNPRDLKEGEFDLGKWLKRMGRSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIX7</accession>
    <name>S0EIX7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to oxalate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436812.1">
        <property type="nucleotide sequence ID" value="XM_023569623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIX7"/>
    <dbReference type="STRING" id="1279085.S0EIX7"/>
    <dbReference type="GeneID" id="35404263"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10799"/>
    <dbReference type="HOGENOM" id="CLU_030515_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485966" evidence="5">
        <location>
            <begin position="23"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="153"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="331"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="495" mass="53268" checksum="E29C5AE27E046CE3" modified="2013-09-18" version="1">MVHRSTFFKALVASLSIAPGSALPAPQMGDYGENKGPVGGVKPPTPTVTSTSGSLYGDSSLLGGNAPLPDPEQDSAIVKDPKLANGQEADPKLGLYLDFDGVDVPQPIRGKLGATDPGPRTYDYERLNPDLFAPPGTDAGDVPNAMWPLGLSHNRLGSEAGAGWARQQNQDVLPAATAMAGVDMRLAPNAYRELHWHTANEWALVTKGCLRVAAVNDEGKSFVDDLCEGDVWFFPAGVPHSLQAFDKGVEFLLVFDQGTFSEDETFLVSELFLRNPVSVLAKNFETETTAFDNIPKDELYIFNGTPAPKDIEKQNVTGSAGALTGNGSYTYHWSQQKPHTVPGGSVKIIDPTTFPIAKGFSAALVVVQPGALREIHWHTTSDEWSYFLQGSGRITVFKAASSARTFDFTAGGVGYIPAANSHYVENTGTEDLIFLEVLQAPKFSDVSVAQWLALTPKQIVKDHLKVSDKFLDSLPKEKQFIKTGDVNMTAIADEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ93</accession>
    <name>S0EJ93_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436015.1">
        <property type="nucleotide sequence ID" value="XM_023568892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ93"/>
    <dbReference type="GeneID" id="35402699"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09230"/>
    <dbReference type="HOGENOM" id="CLU_809039_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="343" mass="39758" checksum="AA918416305AF483" modified="2013-09-18" version="1">MFTYTHDAPVLQGDSLQIKELTISHLADYNDPRVIQSKAWNKLLRLPTLIDLKLLVGEDHVKNRTNLSTERSEFFSVLPSKWLQPDIVQKLQVLSLFYTDFWGLFPRMDLDQLGDLPSLKVLALGRYIFTDKKQTEWIASLGQKNKSGGLEELYLDEYCVLFEAKQHGPLTAGSYPVPGTVMDHNTDIERTEYRRRWHHVLWRLWLSHSQHRVFLSMGPFTEAMLNANNPPEWYFGHNRHRFFADPGPKDFVVRLFDAYRSRRKSSRAVPMGNYLLGAGLTQSRRAQMRYARCDVGLPYGWFIGNQSTKSGSDRPWAPEQETVGFDDAAYALLMETIRDRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJM5</accession>
    <name>S0EJM5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_10927</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436933.1">
        <property type="nucleotide sequence ID" value="XM_023569767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJM5"/>
    <dbReference type="GeneID" id="35404391"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10927"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT74855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="475" mass="51366" checksum="E1E39504BC2178ED" modified="2013-09-18" version="1">MKVPLYASAGVATSCVAFLFGMDTGSIGPITTMTAFKETFGDFSATIHGVIVSTILIPGALTALIAGALAHRFGQVRLIAIGSIIFGIGAAIECGAPYLGVFILGRLIKGMGEGLFLSNVYVQVSEMSPSRVRGIMTALPQFSITTGIVTGYFTCYGTSRLGSSSITWRLPLAIVAFLGLLLSMVAFIVPPSPRWLLSKGRTDEARTVCRQLGIDEVEEKELLAQVYDTPGGLDGETSLWQDIQHTFRDFRCAFSAPYRGRTAFACFLMGMQQFSGIDGVLYYAPILFTQAGLSGEKASFLASGISAVVILAATLPATIFAEQWGRRMQSILGGVLIVGLMVIMGSLYASGQVHPEYGAGRWVVIVCIYLFAIAFSFTWAIGFRTWVVESMPRRTRSSASSLAQSSNWAANYIVALVTPVLLDKSSFGAYYLFAGCSLATTIMVVLFMNETKGYSLEEIEKRHERTRDKRIPLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJQ7</accession>
    <name>S0EJQ7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437097.1">
        <property type="nucleotide sequence ID" value="XM_023569953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJQ7"/>
    <dbReference type="STRING" id="1279085.S0EJQ7"/>
    <dbReference type="ESTHER" id="gibf5-s0ejq7">
        <property type="family name" value="HOD-cofactorfree-dioxygenase"/>
    </dbReference>
    <dbReference type="GeneID" id="35404558"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11094"/>
    <dbReference type="HOGENOM" id="CLU_087588_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.210.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="272" mass="31243" checksum="DB77B30C8D799AC6" modified="2013-09-18" version="1">MLYTRTINGVELSFEDRGMVTSNPTIVCLPGLGQDHRGYQYILPFLVSKYRVIRILWRSHGANSESTGKWSVEDQANDTIALLDSLQVQAFIPISHFQGGWCAMEMAARLGKQRVPAVLLTDFILTRPPAEFIKNLQMIQNKETWQQGQAPLIKKWLNNTSNKNVLDHCENDLDTDGFESWAYFCWLVEKNYERWGSPMERLGAIEDPPLVRHVFSHPREGPYLSEHEEFARKHSDWFSFARFDGESHFSIVELPEAVSLQLSDLVGQIKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJT8</accession>
    <name>S0EJT8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436988.1">
        <property type="nucleotide sequence ID" value="XM_023569828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJT8"/>
    <dbReference type="GeneID" id="35404447"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10983"/>
    <dbReference type="HOGENOM" id="CLU_106789_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058931">
        <property type="entry name" value="SnoaL_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26528">
        <property type="entry name" value="SnoaL_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="189" mass="21964" checksum="C0F68BFB7A1FBCCA" modified="2013-09-18" version="1">MASPEYSPPEEELFKLYREYRETKSIEAKALFFSSQCRQICRTDPAYAAKGRDIILHYLRESGDVLQRIYRDAGWDISEMDPASVKSFYTMRPLITSEREDFATIRELAPAGFASLEEVRDKAKTEKWEGLRVNMWTKDNKGRGILVKVQYWWREEDGAWKQILHDIMFLGPVDGTEKDGRGILVEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJW0</accession>
    <name>S0EJW0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pectinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_11004</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437008.1">
        <property type="nucleotide sequence ID" value="XM_023569852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJW0"/>
    <dbReference type="STRING" id="1279085.S0EJW0"/>
    <dbReference type="GeneID" id="35404468"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11004"/>
    <dbReference type="HOGENOM" id="CLU_040116_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496123" description="endo-polygalacturonase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT74930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="378" mass="39255" checksum="ADD899612D342339" modified="2013-09-18" version="1">MTKLGFALLAALAGSAIAVPAPAVTQAPDVHAYAKRATSCTFSGSDGASKASKSQAACATIILNNVAVPSGETLDLSKLKDNTKVIFKGTTTWGYKEWKGPLMKISGNKITVEGSGAVLNAGGEKYWDGNGGNSGKTKPKFFAAHKLTDSKINNLYVKNTPVQAVSINGVNGLTINQFTLDNKDGDSKGGHNTDAFDIGSSTGVTITGAKVYNQDDCVAVNSGKNIIFQNGYCHGGHGLSIGSVGGRDDNIVDNVQFLNSEVVNSANGIRVKTMKNTTGKVNKVTYSDITLSGITKYGILIEQNYDGGDLHGEPTSGLPITGLTLKNIKGKNGVSSSGKNAAIVCGSSGCKNWTWQNVQVTGGKKYDSCKNVPSVASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK27</accession>
    <name>S0EK27_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437202.1">
        <property type="nucleotide sequence ID" value="XM_023569070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK27"/>
    <dbReference type="STRING" id="1279085.S0EK27"/>
    <dbReference type="GeneID" id="35403768"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10303"/>
    <dbReference type="HOGENOM" id="CLU_760861_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="364" mass="41077" checksum="A2E49C1CE174388E" modified="2013-09-18" version="1">MRPRSVIRPTEKSTDLQLKEEETTESTTLTETEKTEDGSRGSVAAESETGLADSKTENQKIYNDWDCNSDQLPKKSHEFVSASTIYMPYLSYFTYCRHWDSRLLSHDWDLKQGHDHYEELLDTYKGKDEQQHGSPTLDERYYQFAGEDNEAINDQSCRNESQIVSKYLRENERAGDMGIEREPNQRTVVRVNQVWIWAFSTNCVITATSSPLGGSPDLLVEEILNSLSKQGEYGGSGAQPATASELVPAIIDHCIGSYERRSNDGERISVGQTLSHYINRIGRKETTPFDDFRTWSPNEHQQKKTPNDKGKQSFQVESLIGGPSLSTTIETKTTQTARQTHNHGHDSVPRSSITSNSPTLLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELY4</accession>
    <name>S0ELY4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to fructosyl amino acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_11620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437638.1">
        <property type="nucleotide sequence ID" value="XM_023570539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELY4"/>
    <dbReference type="STRING" id="1279085.S0ELY4"/>
    <dbReference type="GeneID" id="35405081"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11620"/>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT75592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="435" mass="48706" checksum="84B4ED203270C040" modified="2013-09-18" version="1">MASSSYLIVGAGVFGVSTAYQLIQKYPNASVTIVDRDPYDGDNRVAASWDWNKVVRADYDDLLYCRLALEAQDIFESDPLWMPHFHKAGVFWVCRSDYAQDVINNYKKLGRASDIQVYTIEEAKKLYGGLYEEADYTGAKEVLVNRNSGWGAAGDSLRAVTREAMKLGVKYIVADVATVQIENGRATGIQTANGEIISADTVILSTGAYTAKLLEYSAARHNLPDLRSGDRITAAGITTGMVTLDDQSFAKMKDMPVGFQGYTYRHNSPFIGSLPPTKDREIKWWGRNIFSNHRAVLPGRVVSAPPDEKDYAQWKVPNSLKEDIDNANRLFFGSKGAHWKYEKHRICWDAFTSSGDFIISPHAGAKGLYVATCGSFHGYKFFPVLGKYVVQMLEDKLEPELKEKWAWDRERPDAALNCEFPNSEMRDLLDPAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELZ5</accession>
    <name>S0ELZ5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_09792</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435496.1">
        <property type="nucleotide sequence ID" value="XM_023568267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELZ5"/>
    <dbReference type="GeneID" id="35403259"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09792"/>
    <dbReference type="HOGENOM" id="CLU_044743_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="9">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="26"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="391" mass="43228" checksum="7C0E68715D5B9CB2" modified="2013-09-18" version="1">MSDSDSDLAIPAWQKAQSDEIDSQNTESAPTPSMSSSTSEVDVPAAEATAEETPQPEIGTDGQERLEVARRFLENDDVRHAPHEKKVEFLKSKGIDEAEIHALLGQDESTTETEVSITSCLAPIYYADNFKAPIPETPNSYAPTPTETLPPTPASHPPVDRPPVVTYPEFLAKAPRPPPLVTKERLFNALYAVTGLSTLIYGTSRYVIRPMVDSQAEARTDFHDLTSRKLDTLVAKLEKTVSEVPPKKPIAAVEEESDAEDPTEMFHRDMGTQTTFPISSVTAMTDSKNNESAAKHNTNQLGSLNKTLSGLKDEYRSQSEGMDKIKTAVDMLRDDLDTMTYTAYPDHSTGYDLYGRSRKPEPDDEIRKVRDNIRRVKGVLLSTRNFPASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMG0</accession>
    <name>S0EMG0_GIBF5</name>
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        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_023568425.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09649"/>
    <dbReference type="HOGENOM" id="CLU_001379_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
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        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
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        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="419"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1069"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1267"/>
            <end position="1299"/>
        </location>
    </feature>
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        <location>
            <begin position="1300"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1331"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1366"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1401"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1471"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1543"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1611"/>
            <end position="1643"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
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        <location>
            <begin position="877"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
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            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="893"/>
            <end position="916"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT73548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2098" mass="233709" checksum="97AD4588B62A35AF" modified="2013-09-18" version="1">MRLGRRREESLSSSDDTTISDQDDEPHYEYILKEMYVPSLSDNSFAGQKDLVETTWKQEGTTEPWFAKPEFLGRLQNSVRVLSFGYNAHRFGDVANTRIIHHANDLLRNLVLKRLDHPAILLCATNDDWKAIKQATKSIIFMGTPHMGSEKAEDLVVVQKLASLMKLQTAVATNLTKELRAFSNSVQDINMEFTIDVHRSIKLLCCYESHPQRLPNGAKEIVSEPCGHVNPANFAKIVPQWSAVLQGVDSIDLNCTHSGLPKFASPLHPRFELFWGEVGRLVRLAEPPPIKPLKKAPTWTDEDVPQYEIPLACPETANFPRPSPRPRQNPPPRRRHEAGKASKVSRESAIRSSVDKLLKEVTSRINADLPTQHETAVSQAQNRTQPEKFDVREFSDFTRLLRSVTPENKGLDREAPHWQTCSWILEDPTFVKWKESKSGSLLFITGSPGCGKSNLAKYIQGAMKASNDERWEESLVIPFYCDSLESSRHNPPILDLVVQSMLSKYTTMSQATRKKLESVLETLGVDRQKSRSPLEAENSGHFIQLMEIVQLLVTAEDARPTCLIIDGLDQCEDEFIIRLLRGLDTIFRRESSVSALKVVVTSRMADSIRGFALANNHIEVTPGLILNDIQKVVDEEVDRIILSRRIATVGRASVSAVIVERSNGSFLFASAVLKELWHIKDTGANSVFTLVTSCPPTMEAIYQQDMDRIQNDRNDLFQLILIICIARSTLRIEEAKEILRFLNPSVTRTYDLVGDLTRTCQRLIRFGAEDTLELLHQTLYDFILDTYDVNLVHQTLATACLNYVREIDWESYYDPWTDYCRDALADQYVFLEYSSAWFRYHLKFFGPDTHKISQDLWDFIRSPAGEKWRYYTFQKRTWGSRSPSPTRSPALFRPQTPSPSRSRTRSSNGSRTRSPPAIERPQTPSSAIDKENEDEAEAGYLSDGTDDSVSACDSDGSGGRGRLITTDQTSIRSAKPPLVLLAQWDADLVIKEIFSQALKLTPNRFLHKIHDLLVHISPKSKQQVEEDLETLVNNIWEGTTAIHYAAAQPGAALEVLLPFARNLDLPDNDGSTPLILAAVRGHCRSVQALLKAGAKIDAVDPWNQTALFTAVDVGAVDVVRTLLEFGADPNISSINGHSPLALATGKNSSEMVELLLEFSADLDAPAFDGKPIPFLASWMASTDALEILVPHNDVDQVWRNERLIHMACFKGWKGVVDKLVEKHANLDDPPRDLPKASPVALAVESGHSDVLRTLLAAGAAVECPVKGMSSPLHIAVAAQNLLGCELLLDAGCQVNAEDKDGSTALSIAADLNDLDMVECLVSHGADSSKPDYETPLHIAVDWGNLEMVEIILSSRFFSDIDAKGEKEYTALGIAATTGRLGIVSMLLDHGADPNIRNGQHNSSAPLHLAANKGHRGIVIELLKRGADPYPETTKESSAFHAACIGGWLDVIETFLEVVDDVSELVNFEWGWAGTPLKAAASGGRLDAVKLLLSKGADPNKQLQSKINRGQTVIHAAAEGGNTQVLEVILDAVDDSSLEIRDRAQRTPLWYACVEGHEDMVKYLLERGASTDVIFDDGENIIPTIVSGGSEKNLKLVLEKNPSLDTDCILADGETPLFKAVYSGYGKIVSILLERGADVNRRSKYGNVPVFGAITNRQNETLRILLEHESMDLTQRDSFDRTALQIAQQSGTRLMPAMVLGSAKDSDVERILTENRDMYGLNAYDLTRPEANNPVPFDRCVEGVRQDAQSLLDDFDLYGVRWERLGKFLLQLGSYSFAQVALQRSARAVETNPLVLKHDNYCDMCLDTIAGPRYVCCTCCTVDLCELCVRQDKKPGNRTWTCDYHTFLAIYLPKIQAPDIMLRTEVDFHIPTRLSPIEEVASETNQGWTEADGDEPFRQPPCLQDDEDAQDIVSISSGDTPNSHTMAIEPLATHSSTAVTSYSFDDGGLPDKATSDSSAVAKEEWSDRTKDELREFLEAVLKTFTAYQTPNGISKWSFSVDGWTLRYKDDALKSSWVEGDENARLIQPVREWTSLQPLTEAYYYLSGLSYLMADVPPYLVATGLAFHGYQDEALKRRRRLQRLHHKVIFPVKRHGEVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMS7</accession>
    <name>S0EMS7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to monooxigenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438147.1">
        <property type="nucleotide sequence ID" value="XM_023571003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMS7"/>
    <dbReference type="STRING" id="1279085.S0EMS7"/>
    <dbReference type="GeneID" id="35405497"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12037"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT76101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="512" mass="58211" checksum="5F22B12D5224B95E" modified="2013-09-18" version="1">MDPSPTAFIPKPLRIIVIGAGISGIQCLKDVTTRLQNVSITAYDKNSQEGGTWAENRYPGCSCDIPSHAYQYSWNPNPRWSRLYAEASEILDYLKATVTKFNLRQYIQFNTTCTGASWDERHSEWHVTLQKSGIPEKEIRLKCDVFILATGRLNNWKLPDIEGLNKFQGSVIHTADWQSGLDYRGKDIAVIGNGASSTQCLAKLSKDSKDTIEEFENNPSSYLRFRQQLEQKLAHSFKGLWAESKAAEEFTQTAKQHMIKKIEDPHALEALLPTDYKAGCRRFTPADMYMEALNQSNVELISTPIKLMEGDAIITSDGKRRTYDIIVCGTGFEPYTPRFPIKGRGVADLSELWSMDGGYESYLAATVAGFPNFFDIVFPTKLRIWNQVFNPPMCPVNGSAYPGIERASDYMIRVIDRLQTDCLKSVCVKQSAQDAFNQWAQSRMHEMVWTGPCSSWFPWPGTMLHYYTATKIVRWEDYDMEFEDKKQKFASFGNGITTEGFNPENIPWIYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMX2</accession>
    <name>S0EMX2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to low affininty zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435861.1">
        <property type="nucleotide sequence ID" value="XM_023568706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMX2"/>
    <dbReference type="STRING" id="1279085.S0EMX2"/>
    <dbReference type="GeneID" id="35402864"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09396"/>
    <dbReference type="HOGENOM" id="CLU_027089_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF24">
        <property type="entry name" value="FE(2+) TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="422" mass="46055" checksum="48098C43436C65E3" modified="2013-09-18" version="1">MDSAKPQCGGAGTGEDYPLGLHVGGLFAVFAVSAFGAGFPVAAKRIKWLKMPPKIFFACKHFGTGVLIATAFVHLLPTAFGSLTDPCLPDLFTEIYPAMPGVIMMAAMFLLFMVELYLNAKTGGHSHGGPTGTTVTVVQPPPTRPQRPFPETANFNHTHTRNDSNGSDDYDDVDYEKAMARELYEKENKPHAYSYEQDSNSSMPAWFVVFYEQYIRQRSEMMDMIKQTQYSNQAVIDDKPSPEVSQSFFDEEGQTIDQATYKRMSMNITLLEGGILFHSVFVGMTIAMTTDGLVVLLTAIMFHQMFEGLGLGARIAAVPYPRGSFRPWLLVLAFGSTAPIGQAIGIASRNSYDPESALGLILVGVFNSISSGLLIYAALVNLLVEDFLSEEAQHLMKKKDKIAALCWIGLGAFGMSVVGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPM3</accession>
    <name>S0EPM3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to lipase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437446.1">
        <property type="nucleotide sequence ID" value="XM_023570317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPM3"/>
    <dbReference type="GeneID" id="35404882"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11420"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013436791" evidence="2">
        <location>
            <begin position="20"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="445" mass="48146" checksum="A20F4701CC2B1D86" modified="2013-09-18" version="1">MALHRALILLSLWLGLAAALNGHILERSDSHKPLPPSRDPWYTAPKGYEHKEPGTVLRVRRAPGNLTRLTGNSSATYNILYRTTDSHYKPTWAVTTLFVPKLGENSTAAMMFNQSALLSYQVPYDSADVDASPSYAAYAPYADSSLALINDALGLGVFLSLPDYEGPLASFTAGVMSGHATLDSIRAVLSLNLGLNKKDPRVALWGYSGGALASEWASELAVQYAPDLQDTVVGAAIGGVTPNITAALLSISGKESAGLVPSAILGLISQYPDARKYVLSQLKTSGKYNKTAFLAAKKYTVFEAGDAFAGVNIFDYFKDGDKILRSPHIQHVINRDGIMGYHGVPPWPIFAYQAIHDEISPIANTDKLVERYCAVGANILYQRNTFGTHSENFVLGSAAAVQWLAFALLGLNDKAEGCTIKNVTTNSTDLSLRKRGMPLRVYDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHL4</accession>
    <name>S0DHL4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423775.1">
        <property type="nucleotide sequence ID" value="XM_023574395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHL4"/>
    <dbReference type="GeneID" id="35395310"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01826"/>
    <dbReference type="HOGENOM" id="CLU_633182_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="53862" checksum="0CE9FE20205B779B" modified="2013-09-18" version="1">MSSSSNNTNGEQQGALTDLPTELLLEILHKDNLEWEDYYNLCRTSSRLSRVAHKPMYQGGDYCVFRMACFRGDLDTLAICAQYGAVPTQCSQKALSDGPLGLIEPGNGLYRRDVEDNYQECWHWNVWGDGSHGPGDIVILGFYEGNFSAERFMKVWQWLSDQGCELFTFMKLRSLVRIPFPCFSHALLSMLPTATDKAHHQGICNVIQFLYREGLRIPHPDRRLWRRGTWPAYYPLARENRPTMLQAMLQTNCPPSILELYLRQVNDEGLVFDYASTWHSSFDGLGSVSQFLSILFDDMFAPWIYKGDSTRSMSDDLQAKICLLTQHQGANAFELYVLRDIVTALRKIDARKVSQGNLEFDRDGVWCWYELCMAVAYISDEDVQKQTVDIHFTDPGDWEMINPYFSRAWSPHKDLSNARRKVLEKRARESGQDPKDVEPQGEEPAGRKWAQMPLDAWDYIPSHSRMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHN3</accession>
    <name>S0DHN3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to quinic acid utilization activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_02011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423591.1">
        <property type="nucleotide sequence ID" value="XM_023580116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHN3"/>
    <dbReference type="GeneID" id="35395494"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02011"/>
    <dbReference type="HOGENOM" id="CLU_007607_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT61510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="767" mass="84037" checksum="86D77ED46CF72CD5" modified="2013-09-18" version="1">MSTTSPDTRSRGQTEASPRASKRARTDTETSDKGPNGRNRHRITRACNECRRRKDRCGGQRPSCKSCIDNNRTCSYGPSKKRGLRPGYVRGIETLLGLIFKSIQGSEEWICALLEGVVQQSSFCPASGLNETNISVDLLLETWHKSSVSKKMASLLSTESEFDEEGADSSQIFDTKVVEGLTLLVSTKDTSGAPMTPMDTNTTQPDIPTFDYSPIPIPVSSSPQCLEKTALHTAINRQPEPESRPSNSMSSAAVPDLPKDWSYLLDLYFETTHCWFPISQKHELLRAAYTLSNGAPTTSTSSLSSGELAFLHAVLAYASHQSTTLSSNSCRKPGDIHSLHSPRSLLETSLFANPTIFDLGHVRALLIICLFEMDQNRWPSAWTTIGRAIYTAISLGIFSQGTAVDPPSRDGIKRTTMGCTQLETIVAARLDTLPYLTSSNIFLQDGLLADGNEEWEPWNLKILVEPEYQQDQQNTNSHVPGHVISTFNRSLQLVLSLNDLIHHKKNLVPAGSFSKLIGLCKENFSAMDSLKSATLSPQTLGLCIALVTLFEMAATEASVSNRPILERPSGYWEIVSFWASLTEKRVRTIGRCAISPVVKACLELVGRSFLQQEAHYTPISIDFNSAKEGVARCLHILQESLGRISQDDVLNDASLVTAGKDGHSLLPIHGKRPVPSHFELPPTPSTLLSSKVGTSVPDNGINSQPTSRMSFPIDPTLGSNIEDDGLFDSLATLDSTNWLANPPEFMQHLGMLDDAPGNLEHLFDMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHV1</accession>
    <name>S0DHV1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_01659</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423930.1">
        <property type="nucleotide sequence ID" value="XM_023576251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHV1"/>
    <dbReference type="STRING" id="1279085.S0DHV1"/>
    <dbReference type="GeneID" id="35395144"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01659"/>
    <dbReference type="HOGENOM" id="CLU_022696_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070156">
        <property type="term" value="P:mitochondrial phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="167"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="383"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT61849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="484" mass="54736" checksum="CC9073AC2F9671FF" modified="2013-09-18" version="1">MRLYIQGMRCLRASAPRPVQLPRSSILLRTACAARTYSSARPTGTPGSVTIRDQTIKTDPQWFNVPDNVLDATTRKLHLLKDHPVSITRQIIQANFPEPTFKYHNEFSPVVSTAQNFDSLGFPANHPGRALSDTYYLNSETLLRTHTSAHQADTFRANESAGYLVSADVYRRDAIDRSHYPVFHQMEGAMSWDRTKVPNGDVATAVWKDFEKLPIHGVKVDDPNPPMHPETNPLQDAHHTAAEAEAIGAHLKRSLENMVVDIFSRAKATAIKDDPNFVDEPLQMRWVEAYFPFTSPSWELEVYYAGDWLEVLGCGVVKQDIYINAGVPNQLGWAFGIGIDRIAMLLFKIPDIRLFWSKDKRFLSQFEGVTDNLDNLKRFVPFSKYPPCPKDVSFWLSSTTAAGGNTKGTFHENDVMEIVRNVAGDVVEDVRLIDEFTHPKTGRKSMAYRIVYRSLERTLTNDEAVAFHEDVRKALVKELGVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHX6</accession>
    <name>S0DHX6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423746.1">
        <property type="nucleotide sequence ID" value="XM_023574051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHX6"/>
    <dbReference type="STRING" id="1279085.S0DHX6"/>
    <dbReference type="GeneID" id="35395341"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01858"/>
    <dbReference type="HOGENOM" id="CLU_012494_3_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="91"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="343" mass="38769" checksum="412E74AC39F7ACCE" modified="2013-09-18" version="1">MIPGIIHHLYTWFRPSLVAIFYRNIPWALRWRLLLFQPAAFLTYSIATIPCLFYRSYTVEYLHIAPGRSVRALIFKAAGVGKGRALRPLHVNFHAGAFMGGLPEGHAYFDQLVSEQTGAVVVDVDYRVAPEHAFPAAVDDADATIKWLQENAEERWGADPTLMTTSGFSAGGNLAFAVTQQKSCQAPSPTSIKAIATFYAVLDFRLSPWEKPHPDNMPKNDPAKVFLPLFDAYAAPARAKHSKDPRLSPVLSQKESLPERILLVAPGIDILVAEQTEFAERINNEDGRREVQRVEILHEKDLFHGYLEVPDIVVKRDIKHRAYDKAIQVLKETHREYDWTWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIH5</accession>
    <name>S0DIH5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_01486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424086.1">
        <property type="nucleotide sequence ID" value="XM_023578173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIH5"/>
    <dbReference type="STRING" id="1279085.S0DIH5"/>
    <dbReference type="GeneID" id="35394971"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01486"/>
    <dbReference type="HOGENOM" id="CLU_036235_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_uL2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="96"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="199"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT62005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="372" mass="41043" checksum="4421C747B5E5B70A" modified="2013-09-18" version="1">MLQSGLQFAAARQSALRMALSRSLPRTYATIRRSNETTASPKELAENPESQSAILRVYKPRTPGVRHLKRPINDHLWKGRPFLPLTFPKKGQAKGGRNVSGRITVRHRGGGAKRRIRTVDFLRNRPGPHLVERIEYDPGRSAHIALVTEKATGRHTYILAADGLRSGDIVHSYRAGIPQDLLDSMGGIIDPGILAAKTAFRGNCLPMHMIPVGTTVFAVGSAARRGAVFCRSAGTSAVVVNKNEETKDDGTRVMTGKYVEVRLQSGEVRRVSKDACATIGVASNIHHHYRQLGKAGRSRWLNIRPTVRGVAMNKVDHPHGGGRGKSKGNRHPVSPWGVPTKSGYKTRRKHNRNKWVVVPRPRNNGKRRDKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIU9</accession>
    <name>S0DIU9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable ribosomal protein L11.e.A, cytosolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_01271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424281.1">
        <property type="nucleotide sequence ID" value="XM_023580584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIU9"/>
    <dbReference type="STRING" id="1279085.S0DIU9"/>
    <dbReference type="GeneID" id="35394756"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01271"/>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="173" mass="19967" checksum="E8E15121B1AE4432" modified="2013-09-18" version="1">MASEKANNPMRELKIQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYELRKRNFSETGNFGFGISEHIDLGIKYDPSIGIYGMDFYCCMTRPGERVTRRRRTKSRIGASHRIKREETVKWFKSRFDGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK98</accession>
    <name>S0DK98_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_01746</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423848.1">
        <property type="nucleotide sequence ID" value="XM_023575284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK98"/>
    <dbReference type="STRING" id="1279085.S0DK98"/>
    <dbReference type="GeneID" id="35395231"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01746"/>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="334"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="398"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="464"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT61767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="740" mass="84629" checksum="5C9F51D3E62FCEF4" modified="2013-09-18" version="1">MAADKAAVASGADLGDGLRQRPVAGQANLQVPTPQPEDNKKLVKKESSLLQTLDQWEVVIAPLIFTLLAIFTRLYKIGISNIVTWDEAHFGKFGSYYIKHEYYFDVHPPLGKMLVGLSGVLAGYNGTFEFKSGEKYPEEVNYTIMRIFNAAFGIFCIPLAYYTARELKLRRPAVWLVTLMVLCENSYTTISRFILLDSMLLCGTVATVFCWSKFHNQRHSSFEPEWFFWLFLTGLSIGCVCSVKLVGLFVTALVGLYTVEDLWRKFGDTKMPVTTLGAHVITRVVGLIVIPFLIYLLSFALHFAILDRSGPGDAQMSSLFQANLKGTQVGKDSPLEIAIGSRATIKNMGYGGGLLHSHVQTYPEGSKQQQVTCYHHKDTNNDWFFYPNRREEDYNPEGDLRFIGDNSVIRLIHAQTGRNLHSHDIAAPVTRGHKEVSSYGNLTVGDDKDHWKVEVVRDSASRDRSKIRTLTTAFRLKHEVLGCYLRAGNVNLPQWGFKQIEVTCTKENNPRDTYTHWNVEAHWNDKLPPAEAGVYKSPFFHDFVHLNVAMMTSNNALVPDPDKQDDLASKWWQWPFLHVGLRMCGWGDDIVKYFLLGNPLIYWGSTASLGIAGLVIVWYILRWQRGVNDLSENEIDHIHYAALYPLAGWFLHYLPFVIMARVTYVHHYYPALYFAILNFGFLIDWFTRNRNKTIQTIVYGILYTVIIGLYIYFIPICWGMTGNHKQYKYMKWFDNWRVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL18</accession>
    <name>S0DL18_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to alcohol dehydrogenase homolog Bli-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425166.1">
        <property type="nucleotide sequence ID" value="XM_023573445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL18"/>
    <dbReference type="STRING" id="1279085.S0DL18"/>
    <dbReference type="GeneID" id="35393786"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00301"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="304" mass="33131" checksum="6586F38621CE1DFA" modified="2013-09-18" version="1">MSIATTYPFDPATDIPSLAGKVIFITGANTGLGKATAIELAKHSPAHVYITSRNSAKGNAALEEVRKTASEGTKVSLLHLDLSSFESIKSAAAEFLKREDRLDVLLLNAGVMGVPPVLTKDGYEMHMGINHLGHALLLKFLKPILGKTPDARAVHLSSAGFRHVGPAGIEFETLKSAKSETALPFRYAQSKLACLLYAREAAKRYPEFKNIAINPGEVQTELFTREAGDDLMKHLQENVAFKVTIPISEGVKNHLWATTAPDIENGEFYEPVGKTGGLEGHGLDDEMAKKLWDWTEEQLKNQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLG2</accession>
    <name>S0DLG2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424263.1">
        <property type="nucleotide sequence ID" value="XM_023580373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLG2"/>
    <dbReference type="STRING" id="1279085.S0DLG2"/>
    <dbReference type="GeneID" id="35394775"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01290"/>
    <dbReference type="HOGENOM" id="CLU_052067_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038967">
        <property type="entry name" value="Dsc4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1746" evidence="3">
        <location>
            <begin position="78"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="355" mass="39717" checksum="80C86C7FFCFE967D" modified="2013-09-18" version="1">MSDDASPSSTAPNEASTAESVNVSSGSRVTWNLPREHSRSARSRAQLHPQRRKKKKSRKKRNPGLARKLEFVTHLLRSLDTLVFAELSGLYYMECSMFRFILRSVGQYLYLTPKDESFPFLMPASPIHVCLVLIPNIICILLHIFVSLPVGPDYHRGYMHGGLVIDFIGQKPPTSRIYYVLVDVMILAVQCLMLTVHTERERLRVTLKTFRPMVPDVAQEMGPTIEDLDAEERGVSRDMPGSLPADEEDGIELQPLRRTSTTEEANSTSGESEPSAREPPIDEPTRSHLSDVLSSGNAIIGEYHVLHSLHNAALNIERTAAYSLRTISYGATMASIEARRRGLNVPARTVQNDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLL8</accession>
    <name>S0DLL8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425585.1">
        <property type="nucleotide sequence ID" value="XM_023573245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLL8"/>
    <dbReference type="GeneID" id="35393966"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00481"/>
    <dbReference type="HOGENOM" id="CLU_035829_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="564" mass="64647" checksum="06BA8194365E1158" modified="2013-09-18" version="1">MDTTIQMVPQKANSRKVRGFSGFDYLGRFTTATFELVAAATSAYGDKYEWGKRFGHRVMIKVTEENRPFIEVVRGNYEEDEDEEPDEIVAFMLPYPGFPRWEDRLTQVSGFCEGADFAIVNFIHPGPEISRFRDTQEPRAWMFDCHLNPQIPVPPNPLHDRLLTNTEFYEALQQERFSKDSENEIIGNTRRIYISNPNGVSILALLKRTPASQVDGFRKLFANYLNPSPVPELGLTETPLALRGRDNIDFLNLKPTTAPINQQQSSCVPDNAVLHVAVFSLMITGRSEQHSTTICLDDEFFDQESRLMSEEEVLILGGREDPITLQPEFKRARSPRAYLLVALDRQLERIVDYHANAHDCLKNSIEIYIAIPEDRSTAMDEWIKRFPLILNKLVHFNSRLAEKVSHFLTDDVMVGSDEVPYGPLWQGLQAELGAIKSLRAIKRYCIQLRDINTGLEHLREAFEDVRRKRKNDYAAEQQTRDRTIEQVTVAAFAKTIRPPGQRTLPWWSSSMPSVSVEFCGLCIATDLEETEQDDEMSLPVYRRLPPPQVLKFTRLHDKTTDFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM53</accession>
    <name>S0DM53_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423694.1">
        <property type="nucleotide sequence ID" value="XM_023573584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM53"/>
    <dbReference type="GeneID" id="35395381"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01898"/>
    <dbReference type="HOGENOM" id="CLU_397424_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="693" mass="78270" checksum="A1D45DEDB53A16E3" modified="2013-09-18" version="1">MTDQTFTYIDICADSRVPSSILPMPTPIVEDCQSVGARRDPPDEPTGIYEQLRTQAVFRGEEGIYGYNLSKLASLDYDDIRTPDEAARWLADERTSILGINREEIQFYDQLRARRGVFSTDVEAVGPLLVQAAIIDADRNVVVGGYIHRDCETVKEVWDLAVNVCGGPLTKIQSDALRKAFGSPSMKRPRGYSMHWLVDQLKTLKKEYPDICMAEWSANPFDQVVYRNNIKRAGYDHEDILPPPENWVFPMGWFRQAGPSLLGLQLAYVACLYHSSSLVFRWHDAIADALMPMDILSTRQPKYHHGKVEVPPPSRSILLLFEQGLQKTTNGEDFLIQRPWFAREDRLCLAFMQDTLKKYESASLPALCRAASYYLLEHKFFRTANSIREHLTEKARRAQSEDEYVTCTDRQAQTLLLSTYNALTGPRSTSRRIVLEPKIDPAAKLLVQQAYKETPHEGRLKPLFWSQCQKQVHALSKSTGSTLNEQELDLALLVMINSRIHIVCKDCGAPKPGVNCHQCRIRECVDCGGVARGFSRCSPCFYQYYKDKEKKGCMVCRRVCYGKICRSCEHQDSGLDLLICVAKGCSADRVESSRRCASCFRKRRDQRKKSSQLWPPDNQGPIILNKGDCQDCGDERPAKGNATGACHSCQQRASRLEALEVNENTVYCQTRAEDGECTGGHEGVKELSESGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DME4</accession>
    <name>S0DME4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6923 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425672.1">
        <property type="nucleotide sequence ID" value="XM_023571353.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DME4"/>
    <dbReference type="GeneID" id="35398744"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05263"/>
    <dbReference type="HOGENOM" id="CLU_000889_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008440">
        <property type="entry name" value="Agglutinin-like_ALS_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054215">
        <property type="entry name" value="DUF6923"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05792">
        <property type="entry name" value="Candida_ALS"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21959">
        <property type="entry name" value="DUF6923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494975" description="DUF6923 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="2471"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6923" evidence="2">
        <location>
            <begin position="2265"/>
            <end position="2465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2471" mass="259542" checksum="C93D0FD7F3FCA085" modified="2013-09-18" version="1">MLKAMRMYKSTCYGVIFVLFAFASAWDPVVDCPDSEKRAEVQPIKVVDGSITFDTTLASTFLIPHEASYITTAVFGLGPPSTYTVAPQGTPPVGTVIKRTPLTTITSIISSLKTARTRTLTPDQPGDPTTVVIEEPEYRTRIEGVEIDHTRTVQVGVPGGPGDPETITVGRDYYTTITEKGSNGDPVTKVVHVDDRTTIDVGRTTITQTRDIQSPVTRTIQPDSSGGVSTIVIEVPKSTPAYTTVTRTGTVTTPVTSTQPALSSGGTGTVFIILPSDPVPYATITRVGTGTSTTTSTQPPKHPGEAGIVYVDIPEPLGRYNTVTRFGTGSAPRTFTQTPNGPGRDGEVVVEIPITDADYNTITQVGTVTAPVTRTIPPSSPDGTGVIIIEVPPARWATVSHIGSVTRPVTHTISPTRAGDAWSVIVELPPVNTRLIYTTRYGEVGSASTTTRFPDGSSNTAWVIVDLPNPMTTTIRGGDIESPMTITQEPANPGETGVVLIITPYKYITTTRTWTGSEATTITQKPSDPNEEGTIIVQVPADTVTDVTVTSQWMGSVTRSSTVPPSDPVVPPDVTPFVTVTEYWTGSTKQTETFPPSASGASGTVLIQIPEDSLHYVTTSEWWTGSTRRTITIPPSEAGGTGTKKVLFPTAAIRYIDTSSVWTGSTTREWTEYPAGPGETGVIHHDVPAMRYVTVTNYGPGSSTRTYTQEHSGSGITDTIVVELPWITSWTTITSTGTDSMSRTSTQMPSGSGRLGTILVEIPPTAIAWTTTTITGSDTVTQTVSQTPGPGKTGTVVVIVPPAIDHYITKTIAGTGTGTITRTQTPTEPGATGTVIIEEPAAAVKYVTLTSRWTGSAISTSTKQPDSPNDQTRTVIIFVPPSVTPYVTTTSFDYTISVPYTTTVSPTRDGQTGSVIVVKTVVYVTTTRYGSVLATSTQTPGNPEETWTVVIERPQPFTTITRWAATISAPSTTTESPQNPGEPVTVLVSLPETFTTVTRWAFTVSVPFTTTQAPQKPGDPITVVVNFKQPVTTITSWEPAITAPSTTTWMPQVTGDPISVIIFSPQLYTTITRWATVSVPTTVTQTPQSPGDPITIIVSLQQPYITSTQYGRVTIGTTRTLTAATLGQPITILADLPQAYFTTTRYGSVSLRSITTQMPTVEGGLASVIVDLPQPYTTITRWEPTISVPITATQSPQNPGDPISVIVELPQAYTTITSWGGVSVPSTVTQVPQSLGGTITILIKSPQSYITTTRYGSVSMGETATETATRLGEPYVVVVKVPYTTVTVTTIYSGTSVLTGPTAISTIAASGSIPGTVIIATAAPQLITITRLYTGTAVINAPTTVTTIPNSGTVPGTVIIETPQSYVTTTRYGSVSASTMTTELPVSADGTALVIIDLPQPYTTITSWGGVSVPSTITQTLQSLGEVITVIEHLPQPYTTTTRWGSVTISSITTKSASVEGQEETVIIDLPQPYTTVTRYGSVTASSVTTQMPTLDGETATVIIDLAQPYTTVTRYGSVTASSITTQMPTVDGEYASVFIYLPQPYATIYRYGGVTVSSITTQMPTAEGEVASVYIDLPQPYVTTTRYGSVSVSSITTLNPASLGGTATVIVDLAQPYTTLTRYGSVTASAITTQMPTVEGDVASVYIDLPQPYTTIYRYGGVTASETTTETGAMPGGTDTVYIDIPFSTTTITELYTGALSITGAIAVSTIPASGSVPATIVMATPPVFSTRFYTGASPISGPVTVITLYGSGSDPATVVVETPPVTITQRYSGSSTVTLTTITPTGTEDGTVVIGIPSPQPVTSYRQYSGTSPVSAAVTVTTLQPSDPDDPATIVIETPLVTITRPYTGTEVLSGQTTVTTISGTVVVETPPVYLTRFYTGSNAITGPTTVSTISPSGDHPGTIIVETPPITITRFYTGTEILSAPTTVTTITPTGTEQGTVIVETPPITSTRFYTGTETLSGPVTITTITPTGTEAGVVIVEKPPVRVTRFYTGTSVISGQITVTTIVPTGTEDGTIIYETPPITVTQFYTGTDVITGPLILTTITPTGTEAGTVIVATPPVTITVFYTGTDVLTGVTTVTTITPTGTEAGTVIVATPPVTITQRYSGTSVLSGPLTLTTVTPTGTEAGTVIIATPPPATVTSTRRYTGTSSLSGAITVTTLQPTGTNDGPTVVVETPAPQPSTSYRQYSGTSSINAARAVTTYPPTGTDDGGIVVVETPAPPPAFSCDEGGYLIQVRTLYRLNLVTGVNSLVAQNVGPGAPSGTTNGGTINPIGYNIKDNLIYGIVQIATGKSQVIRIGSTGSYTLMNTFIDGTWNTGDVDSDGIFWISTYGKAWAKIDVNPTSATYGKVLEQGTATSANNCADWVSVPGGGRYLYALQGNTSKTVLARWSLDTKTWEVIKDFGHIAGDNLWGAAYSVGNKLMYASENTSGVIYRFNVETGAKSLVINGPKTSQNDGARCVNASPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMH7</accession>
    <name>S0DMH7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to transcription activator protein acu-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_05199</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425731.1">
        <property type="nucleotide sequence ID" value="XM_023571424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMH7"/>
    <dbReference type="STRING" id="1279085.S0DMH7"/>
    <dbReference type="GeneID" id="35398680"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05199"/>
    <dbReference type="HOGENOM" id="CLU_012101_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT63650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="672" mass="75037" checksum="5E18926104FC73EB" modified="2013-09-18" version="1">MPSNACDRCHRRKVRCDKIQPQCGPCKRADVACEYAVSEHQLRRRNVQKLERRIRELMDCNEGLTQQLRRSEEVARRSEDVTRRSEDVTRRSEDVERGEASVVQDSPGDGEVAEEVIQMSLIAGGGHHFVGSTSGLLLANLLQSRPQPSSSLTTSWKPNSLPGLSSPQTNSGLPPKTLASELLKAYCSHDHLCYPFLSTKSLYRSLDAVYEDSSAKDPVDAFFVDMTLAIGTAQVHKFNWNGVYDAETHYNRAMTRLADVLARDGIERLQALLLVCQYRMGTTSSNTTTSVWHLIGVAARTCLEMGLHRAATYALPRTLDEPTRKVKEEEMETKRRCFWSLVALDRVTSLALGRPLALQLEDIDVDLPPSSTADQLPEDSSPLSSAPYGTPQYRAATSVFVHIVRYRLICGKIINALHRSAKHVTFPNTSYDEMRTALARELQEWHTETANLPLVKSDTAASPASGSSFRSEEWYRLLYHNGMLMLFRPSPCLNDAAVNSLALQNIYDSAREAISLYASLHRSRKLNYSWITMHSVFLAGLSYIFALRHHFSGSEPQRARLHTTPTISQVVNDTRACSKVLVAVSERWDLARNCSDLFDRLSDAVVADVVEASVAAPVQFSADLAGMTVDSTFRDCFGDLQSLGLDEFHNDAISQLSQEWFFGLGGESHSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMK9</accession>
    <name>S0DMK9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425761.1">
        <property type="nucleotide sequence ID" value="XM_023571460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMK9"/>
    <dbReference type="STRING" id="1279085.S0DMK9"/>
    <dbReference type="GeneID" id="35398648"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05167"/>
    <dbReference type="HOGENOM" id="CLU_010591_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="74"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="122" mass="13509" checksum="D5A33B55A22EE612" modified="2013-09-18" version="1">MPIQTGMTKSCNKYHTVKSTTTCASIQDYYKISFADFYASNPSLVGQKPSPAQPSNGATTPSPIQSGITKNCKKFHQVKSTTTCASIQNYYKITMANLFKWNPAIGSTCKSLWMDYWVCVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DML2</accession>
    <name>S0DML2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable aureobasidin-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_00842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424673.1">
        <property type="nucleotide sequence ID" value="XM_023570563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DML2"/>
    <dbReference type="STRING" id="1279085.S0DML2"/>
    <dbReference type="GeneID" id="35394327"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00842"/>
    <dbReference type="HOGENOM" id="CLU_030747_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000015">
        <property type="entry name" value="Aureobasidin resistance protein Aur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="6">
        <location>
            <begin position="209"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="454" mass="50969" checksum="35FFDB96D797370F" modified="2013-09-18" version="1">MNDFSATLSGKPKLQLLWPEHVNLPFLNTVPHRYRIGRRRTKSKSRPGNEEITSLKTSFNAWDGVRDLQKHHWRTSDLQYAVVGLLILFSFWIAPPAPGVKLLAIIGSVWILLMPATRQFFLPSVTIWTWLLYFFCSRFIPNEYRPHIWVRVLPALENVLYGANLSSILSAHQHSVLDILAWIPYGLCHFGAPVVCALLMFVFAAPGTAPVWARTFGWMSILGVTIQLLFPCAPPWYEMEHGLEPAAYGMPGSPAGLARIDAIFGIDLYTTNFSTAPVPFGAFPSLHAANAVLEALFMSHCFPQFRTYFIMYAGWVCWATMYLSHHYAIDLVVGGLIASCFFYAAKARWLPRRQEGKITRWEYEYVEYGDRNAISDEEYGEYFGMGLLGRPRADSSDGWTVASSSCSSSSGTLSPTLSEEALPGMLMDMDNNGQLWDGNAPARDVELSEVVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN71</accession>
    <name>S0DN71_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425967.1">
        <property type="nucleotide sequence ID" value="XM_023571709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN71"/>
    <dbReference type="STRING" id="1279085.S0DN71"/>
    <dbReference type="GeneID" id="35398426"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04945"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="17"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="364" mass="39154" checksum="1AC53D680D48F0A1" modified="2013-09-18" version="1">MPRALTLQQIEGAKPGKVYYPLQVKQVPKPTPGPNEVLVNLSAAALNHRDLFMRRHLYPAISFTNPILADGYGTVVALGSNVTRKNLLNKPVILTPMRGWESDPVAPEDSRKFAVTGGSKLTEVGTAQDYIVVSEEEVEPAPDHLTPAEGAALPLVGVTGWRALVTKSNAAFPGSNILITGIGGGVALQVLQFGVAMGCNVFVTSGDEAKITKAKEMGAKGGVIYKNEAWDKELRAQLPANRPHLDAVIDGAGGEIVAKTVRLLKAGGVIVQYGMTVSPKMDWLMAANLQNIELKGSTMGSRKEFRDMVAFVNEKKIRPVISRTITGLDNLQGIDDLFRDMDQGKQFGKLVIEWDSGSESPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNQ1</accession>
    <name>S0DNQ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424304.1">
        <property type="nucleotide sequence ID" value="XM_023580895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNQ1"/>
    <dbReference type="GeneID" id="35394728"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01243"/>
    <dbReference type="HOGENOM" id="CLU_2263978_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT62223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="103" mass="12116" checksum="CA32EE9802F9DEE6" modified="2013-09-18" version="1">MAQLPIIFELTQADCDNDVYLSLDLTSISQMEGCTVDEYEATISFERWAYDEAMRRWEIIMHPYTDLTVEPLWYRKEPVIEPLMSMLMQKDRIVDPAALSEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPU8</accession>
    <name>S0DPU8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426645.1">
        <property type="nucleotide sequence ID" value="XM_023572539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPU8"/>
    <dbReference type="STRING" id="1279085.S0DPU8"/>
    <dbReference type="GeneID" id="35397685"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04204"/>
    <dbReference type="HOGENOM" id="CLU_043071_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="2">
        <location>
            <begin position="120"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="389" mass="44367" checksum="342BED7F6768BCDE" modified="2013-09-18" version="1">MSSDADTSSSSPSEHATFGRDEQAKAQPIMESITEVPEPERSAQETIRDYLLENVEEFRRLHELRRKGWEASQGDAHFKKQRAVADKCSADSTQFFYTMMKTIAIDLDKATGALNMSKVEQPALLDMCVAPGGFVDVAWAKTPGIHVRAMSLPVEQGGHDVKMLDAQVDVEFRDITTLAADMGITKNDVPLNFPGPYDFLFEKVFDDTERFDLVFCDGQVLRTHPRAEWREPREATRLALTQIALGLGHLKNGGTMVILMHKLDSWRSFDLIHQFSKMATVKLYKHYRHHKIRSSFYLVAKNIQAESAFAKEMVALWKRTYKIATFGTDAEYAEMHRVTRETALVELGKFGEKYVAMGKKIWKTQADGLEKAPFLKKYTKQKSKRRTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPW6</accession>
    <name>S0DPW6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_00494</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425538.1">
        <property type="nucleotide sequence ID" value="XM_023573231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPW6"/>
    <dbReference type="SMR" id="S0DPW6"/>
    <dbReference type="STRING" id="1279085.S0DPW6"/>
    <dbReference type="GeneID" id="35393979"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00494"/>
    <dbReference type="HOGENOM" id="CLU_096618_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT63457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="182" mass="19737" checksum="322E0C382ECB23CD" modified="2013-09-18" version="1">MASIARSSLLRQTAMASRLAAVPATRSTFMPMPNIRSQLKGVAAFHNTARRSAILPPGPQRIEGGVNDPAPIPEPNAAHGSYHWTFERLLAAGLVPLTVAPFAAGSLNPTLDAILCSVLLLHSHMGFQQVVIDYIPSRTYPGLRKIFNWLLNIATVLVGVGLYEFETNDVGITEAVRRVWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQT1</accession>
    <name>S0DQT1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Urease</fullName>
            <ecNumber evidence="2 9">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_00497</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="11">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424984.1">
        <property type="nucleotide sequence ID" value="XM_023573226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQT1"/>
    <dbReference type="STRING" id="1279085.S0DQT1"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="GeneID" id="35393982"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00497"/>
    <dbReference type="HOGENOM" id="CLU_000980_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="14">
        <location>
            <begin position="400"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12 13">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="10">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT62903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="836" mass="90095" checksum="FF38D1A326139E77" modified="2013-09-18" version="1">MHLVPKEIDKLVISQLGLLAQRRLARGVKLNHSEAVALIANNLHELIRDGNHTVSDLMALGATMLGRRHVLPSVCTTLHEIQVEGTFPSGTYLVTVHNPISSDDGDLRRALYGSFLPVPDNSIFPMAATEEYQLDKQPGAVVPVKTKKITLNEGRKRIRLQVTSTGDRPIQVGSHYHFIETNPQLEFDRICAYGYRLDIPAGTSVRFEPGDTKTVTLVEIGGNRVIRGGNNLASGVVDLSRADEILARLQEAGYAHKPDPAGYMAHIDVFQMDHASYATMFGPTTGDLVRLGSTDLWIKVERDETVYGDECKFGGGKTLREGMGQATGRHDAETLDLVVTNALIVDWTGIYKADIGVKEGMIVGIGKAGNPDVMDGVTEGMVVGSCTDVVAGEGKIVTAGAIDTHIHFICPQQVPEALASGVTTMLGGGTGPSAGTNATTCTPGAHYMRQMLQACDQLPINIGITGKGNDSSPEGLRDQVNAGACGLKLHEDWGCTPAAIDACLSVCDEFDIQCLIHTDTLNESGFVESTIAAFKNRTIHTYHTEGAGGGHAPDIISVVEHQNVLPSSTNPTRPFTRNTLDEHLDMLMVCHHLSKNIPEDVAFAESRIRAETIAAEDVLHDKGAISMMSSDSQAMGRCGEVVLRTWNTAHKNKVQRGWLPEDEGTGADNARVKRYVSKYTINPAIAQGFGHVIGSIEVGKFADLVLWDPAWFGTKPSHVLKGGHIAYAQMGDPNASIPTVQPIIARPMFSPHCASTSILFVSSASIETGAIASYGLRSRIEAVKGCRNIGKSDMRHNDLKPKMRVDPESYTVEADGEVCVAAPAETLPLTQQFYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRT9</accession>
    <name>S0DRT9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to sexual differentiation process protein isp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_04720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426178.1">
        <property type="nucleotide sequence ID" value="XM_023571959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRT9"/>
    <dbReference type="GeneID" id="35398201"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04720"/>
    <dbReference type="HOGENOM" id="CLU_004965_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="814"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="862"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="934"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="985"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1013"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="701"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT64097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1077" mass="118595" checksum="3E1F74CDDE1E188B" modified="2013-09-18" version="1">MGKHTTNSSSASISSSKRSLSRQSSASSSLAERVGDRVAGDSPPLRQDVALQPLTSTSTSASSSSARSTVTVSPSHPVQAKGHVLPYQAPASHIPPPSLSTAATPAASAFASTPASASTSTHASAPTSAAIPPVLVGNQDAAQPLDHIDSDDSLDAIPQPIDDTIDMASKKTPFLRSAAARSDAAPYGSVSLTPSRNNSPAGSDRWDPDSHQLRHVPDTMRSEASHRSTLGKKSSSRLSEEIDGAVLVSGLEGRLGITEPTHTGVLEGSMKDDLSEDGALLDDASSAASDSGHQENSPHEAVRASVPPTDNTTLSINTPRMWCLSVIFAILGSSTNLFFSLRYPSVAITPVIALLLVHPLGHLWDFVLKRPYDPEEEFIDGVRTTSVSDDAHGSHKIKRRTRWRRWLAQGRWNEKEHTCVYVSSNVAFGFAFATDVIVEQTQFYNQEAPIVYQLLLTISTQILGYGFAGITRRFLVRPSGMIWPGTLMSAAMFSTLHKQENKPAGGWTISRWKFFYIVWTISFLFYFLPGLLMPALSYFNVITWFAPKNVVIANLFGVSSGLGLFPLTFDWAQVTYVGSPLLVPFWAAMNVIGGLAVVMWIIAPILYYTNVLFSSYMPILSAAVFDNTGKVYDVSKILTHDFLFDREAYQSYSRVFLPITYVLSYGVQFAGLAALLTHTACWHGQDIWKSWKRALEEAREDGQPKYEPVADSPGPLPRQSFDEDQRRMSTSTSHVDGIISREDIHSKLMKRYKDAPLSWYLITFLSMAAIGIFVVEYYPVHLPWYGLLLALGLGALFFIPNGIIMAVTNQHSSIYLICQLICGVVFPGRPIANMVFVTYGYISSAQGIKFASDLKLGHYMKIPPRILFLVQIVATLVSSLTQIGVLNWMFANIKGICTSEALNGFTCPIARVHFNGSILWGVVGPNEFFGPKAIYRSLVWFFPLGALLPIPLWLYCRRNRSSILRKVNLPVIFGAMSWIPPATGLNFSVWVLVCYVFNYLIKNRHNAWWSKYTMTLSAALDSGLAFGIVVVFFGFIYPGLAKNLKWWGTEVYKQGCDWQACSYNTLPEGEYFGPKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRW6</accession>
    <name>S0DRW6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable amino acid aldolase or racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425389.1">
        <property type="nucleotide sequence ID" value="XM_023573717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRW6"/>
    <dbReference type="STRING" id="1279085.S0DRW6"/>
    <dbReference type="GeneID" id="35393544"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00059"/>
    <dbReference type="HOGENOM" id="CLU_031639_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06819">
        <property type="entry name" value="PLPDE_III_LS_D-TA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="3">
        <location>
            <begin position="262"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="366" mass="40108" checksum="860F84A57DCF03D0" modified="2013-09-18" version="1">MYSPKVGDSLDSLDTPSMIVDLDVMEANITKLMDRLLPTGRNIRPHLKTSKSAIVAKKLVAAGAKGGCVAKLSEAEAIVAAGFADLLITCEIVGPAKVKRLVELFRKHREIRIVVDDQRAATTINDALEKSGIEDPISVLIDLDVGLHRTGTQPEGALPLAKHISSLKHMRLIGVQGYEGHLQHLPDFEDRKKQCLESMRILIETAQALKNEGFNIQVVTTGGTGTADFCATVPGVTELQPGSFIFMDTDYRNAIGTYYSHSLSFLATVVSKQGERQVTIDTGLKSLTTDSGLAECKDQRYSYFQLGDEHGALTWEDGTPALDVGDRVEMIPSHIDPTVNLHDFYYAYRNGIIEEIWPVDSRGKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS18</accession>
    <name>S0DS18_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427445.1">
        <property type="nucleotide sequence ID" value="XM_023574014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS18"/>
    <dbReference type="GeneID" id="35395782"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02300"/>
    <dbReference type="HOGENOM" id="CLU_102245_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484461" evidence="1">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="170" mass="18951" checksum="DC6AB06C50DD8DFE" modified="2013-09-18" version="1">MLVSQSLLSLGSIFSAVTTLPGCGEVNVFYTGLPGRHTYVTQQGYDAALVEAQIFNHTRQLREAGYNVRAVWRGPEIPGTEMSKHMKDVHWHVAGVGFGVRGSQILDVITLFEETLDIYREEAPDAKLVFNYNPLTFLWSVKRYFPLSSDCKDRPGKDLGYITICDGACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTM6</accession>
    <name>S0DTM6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to 3`-5` exoribonuclease required for 3` end formation of 5.8S rRNA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426823.1">
        <property type="nucleotide sequence ID" value="XM_023572757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTM6"/>
    <dbReference type="STRING" id="1279085.S0DTM6"/>
    <dbReference type="GeneID" id="35397489"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04008"/>
    <dbReference type="HOGENOM" id="CLU_063514_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000024">
        <property type="entry name" value="Similar to exosome complex exonuclease RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="3">
        <location>
            <begin position="160"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT64742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="268" mass="29069" checksum="3BD4DBFA191B84DC" modified="2013-09-18" version="1">MPLDTSTYSLALLRVDGRRWNELRRLHAQIRTQDAADGSSYLEMGHTKVMCIVTGPSEQQVQRRGGQQAPRDTAAINVNVVVAGFSSVDRKKRGRNDKRIQEIETTIANAFSSNLHTHLFPHSSITISLHVLSQDGSLLAALLNATTLALIDAGIPMTDYIAACTAGSTSTYAAGDDTADPLLDLNNQEEQELPFLTVATQGDNDQVAVLVCESRVQVSRLEGMLVVGVDGCKQVKQFLDQVVKDKGAEMVREGAVEKNDAMGMDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTZ6</accession>
    <name>S0DTZ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 17">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 17">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 17">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_02911</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 17"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428006.1">
        <property type="nucleotide sequence ID" value="XM_023574698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTZ6"/>
    <dbReference type="STRING" id="1279085.S0DTZ6"/>
    <dbReference type="GeneID" id="35396393"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02911"/>
    <dbReference type="HOGENOM" id="CLU_021710_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000275">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000011">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017075">
        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 17" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 17" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="19">
        <location>
            <begin position="45"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="20">
        <location>
            <begin position="244"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="18">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT65925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="389" mass="45280" checksum="366EDF50A0C6063D" modified="2013-09-18" version="1">MAQQDGPIASIAEPGIKAQGQLLHEMRKEVANLLNRSATGFPGAQPVSFARQHLEELAQHDYYVVEKSDGIRYLLYSTTDENGNEAHYLIDRKNDFWFITNRSLHFPLENSPEAFHTNTLIDGELVWDIGSDGKRVPMFLVFDCLVLDGALLMERTLDKRLAYFDQRFYRPYKKLYQEYPQELEFQPFYVEMKKPQFAYAIDMMFRDILPKLKHGNDGLIFTCRTTAYKHGTDNHILKWKPPEENTVDCRLSLDFVEVEPSDEERREGITEPFIDYDSVPKADLYVYAGGSGPEKYEYFNSVFISEEEWETLKSLNDPLNWRVVECNIDEQGRWRIVRFRDDKNEANHISTTKSVLQSIEDRVSEKDLYRAAGEIKNAWKARASRGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUQ0</accession>
    <name>S0DUQ0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to aromatic-L-amino-acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_04532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426344.1">
        <property type="nucleotide sequence ID" value="XM_023572170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUQ0"/>
    <dbReference type="STRING" id="1279085.S0DUQ0"/>
    <dbReference type="GeneID" id="35398013"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04532"/>
    <dbReference type="HOGENOM" id="CLU_011856_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT64263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="505" mass="56234" checksum="221FA0149859C6C2" modified="2013-09-18" version="1">MEAQEFREAAKAAIDEMTDYTENVADYRVVSNVKPGYLRPLLPSSPPTDPEPWSAIHQDIESKILPGITHWSSPRFMAFFPCASSYPAALAEIYSNAFSGAHFNWICSPAVTELETIAMDWLAQALGLPECFLSGGSTHGGGVIHGSISESLIVNMAAARDKYLASVTAHLPPGSEEKDEALWNLRSRLVALGSSGTHSSTKKVAQVLGVRFATIPVSEADGFSLRGEALAATIESLRARSLEPFFLTATLGTTDVCAVDDFEGIAQALKPTFDTPRDIWVHIDAAYAGAALVLEEYQHLARAFSSFHSISFSPHKWFLTTFDCTAVWVRHRSWLIQALSIKPPYLRNQYSDDELVTDYRDWQIPLGRRFRSLKLWFVMRSYGISGLQKHIRNGVDLAESLEDKIDSRRDIFSIFTPARFGLITIRINGESEQQINDRTEAVYEAINAAGEFYLTATVVNDKFAIRVCTSVTKVEEQHVQRMFDVLVQTAENEIAKGHKWLECNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVD2</accession>
    <name>S0DVD2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to TOB3 (Member of AAA-ATPase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428511.1">
        <property type="nucleotide sequence ID" value="XM_023575309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVD2"/>
    <dbReference type="STRING" id="1279085.S0DVD2"/>
    <dbReference type="GeneID" id="35396941"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03459"/>
    <dbReference type="HOGENOM" id="CLU_004471_4_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="746"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="988" mass="111975" checksum="FECE0CF361312934" modified="2013-09-18" version="1">MDSPTRSVSPAPKNKKDKADDKDDSEEEDIHQQLSRLLRREGHLFAKPSMLALPRRPRPAPSNTRISNPLKSPKGRIPPPPPIMAVPRTPRPGIQVMPPQPPPPPPPIDRSSTLPGEWINPNDHPPPPPPVYPQTIQPPPQSPLPPVVKPAQTHYTISEDAIGASNRDKLAAIDNGPIMPKGANAGININNFNHSLAPPVPPPVTWRSSGPTRGYRIPTFTKANKEQTEAQTRLLEPNPMPIGATELQHESGPSNVGKTTEAHGLSQIQEEGSHDFADVTGEDISSHQILKRIPPFEKISTGPMDLPAKVQLFYCLERVEPEDDSVDERSRTVYLSPPEWVVFGDDVDLRGRFPITDPGDYAEEQGASLIVYKYYSVDYQYDAVNAAKRAKQPLPEPEPASQDVVLVTEEMVEAVEALFELFPSMSDDFPYVYEMGSLQDPHLWWYHCRTGFKMEALSERHAQLVGLLVEWIESNFAPLYDQIDDQFKRGKVSSDSIEFLIRPGDTLVADKNGRYSGRVATTRPAPHKQKKKSDDSDKEQEKQGTHTWIVETRSYGYAGKFFAVDRELFIDFPPKYRGGEINITDLNVIPLSYAKPRVKEILRQRGKRFWKLREKTLISYEGSDSDRIQAGQRFMVDFDTYKELHPGSSYMRQEGYISGRKPNLPKDGSEPEEPEIYLFPKLIPGFDLRRKKWVDLEVDRIRDVSWNKEAFKSLVADEAMKELVLALVTNQLDAEKNTDLIESKGSGLIMLLHGSPGTGKTFTAESVAEIAKKPLYPVTCGDIGTEPADVEKYLESVFHLGKVWDCVVLLDEAEVFLEQRTLQDLKRNALVSVFLRALEYYEGILILTTNRVGTFDEAFKSRIQLALRYEKLKDYQRLQIWKNFLVRLKSLGEEESIDFDDIELYLEELAKYPMNGRQIRNSITTGRQLAKYKRKKMTFAHLKRAIDVADKFDRYLADVQEGDMEEFSGRGESGRYTPEYLARADQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVJ6</accession>
    <name>S0DVJ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Related to pisatin demethylase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_03535</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428581.1">
        <property type="nucleotide sequence ID" value="XM_023575393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVJ6"/>
    <dbReference type="STRING" id="1279085.S0DVJ6"/>
    <dbReference type="GeneID" id="35397017"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03535"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT66500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="551" mass="63229" checksum="08189C7CC4B2D8F0" modified="2013-09-18" version="1">MAILQAHFDPAYYCLFFVLGILTHLFIFRRGEWNLYVFNILQAFAVLEISLVYIVARAVAGEDFTLWKVTAISSCFTLSTLTGLSFSMLIYRGWFHRLSRFPGPFWARLSNLYITFHAFKKFRLFEEVQQLHRKYGDIVRIGPTELSIIDPLALQAFHSNSSPCTKGPWYSVEHPIRALQMTRDKEEHAYRRKAWDLAFSSKALREYEARVAGYTTQLFEQIEASQGTPIDASLWFNFYSFDVMGDLAFGRTFDMLKNGTAHPFMKLVHSNMLMAGSLSHLTWIFPLLKRIPVLNQKNLEFQGWLKQQVDWRQKNKPDLPDVFSWILSDYDALNKPTAQDTINLHGDAQLIAVAGSDTTAASLTCLFFELAINPQTCLTLQRELDQYYAENDKPDHSSLSKLRYLQACINESMRLYPAIPSGLQRMTPPEGLDIGNTHLPGDTIVTIPTYTFNRDERLFTHADKFIPERWTTKKELTKDPSLFVPFSIGQYSCVGKQLGLMEIRFVASQILHKFNVELAHKDVATDFVAGLRDGFTLAMSSLYLVFTRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXK3</accession>
    <name>S0DXK3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428183.1">
        <property type="nucleotide sequence ID" value="XM_023574909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXK3"/>
    <dbReference type="STRING" id="1279085.S0DXK3"/>
    <dbReference type="GeneID" id="35396581"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03099"/>
    <dbReference type="HOGENOM" id="CLU_1489133_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="181" mass="19461" checksum="3B556742C45390B1" modified="2013-09-18" version="1">MTEISEKAAAATSSSNPSRPSSSSHSGSGSTDKDAVRPHMKSSSDPDNENLDLTKADSAVIVPPKAENIEDHYRHLPPDEAEVLRRQVVSPEVKQGVAVLYRYASRNDILIILISSICSIAGGAALLMNRRVDNCVFSAQSSGAILSVSQHITGNLRITQIKKFHSVESMFLVNALIIPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXV9</accession>
    <name>S0DXV9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_13608</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429480.1">
        <property type="nucleotide sequence ID" value="XM_023576312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXV9"/>
    <dbReference type="STRING" id="1279085.S0DXV9"/>
    <dbReference type="GeneID" id="35407062"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13608"/>
    <dbReference type="HOGENOM" id="CLU_049944_5_1_1"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT67399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="252" mass="27840" checksum="C3D4884E38DF7438" modified="2013-09-18" version="1">MSGSNGNIPKDVTSSNSPAIDKQKTLLSADVGHFSLVRAMHLADLITLMNGMYTLTTETAAFDMLRACGVMSIFSSLRYALGDPKDFDNLWLALFFLPFGLFFDFFDGKVARWRKKSSLMGQELDSLADLISFGVAPAMVAFTLGFRSLADTAGLTFFVLCGLTRLARFNVTVSVLPKDASGKSQYFEGTPIPTSLGMDAIMAYWLSQRWVHDNLPFGVWFQGSVFEFHPAVILFMIHGCLMTSKTIRIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYH0</accession>
    <name>S0DYH0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427589.1">
        <property type="nucleotide sequence ID" value="XM_023574188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYH0"/>
    <dbReference type="STRING" id="1279085.S0DYH0"/>
    <dbReference type="GeneID" id="35395938"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02456"/>
    <dbReference type="HOGENOM" id="CLU_181953_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6593" checksum="31E35F8664185E0F" modified="2013-09-18" version="1">MAGHGHHSFNGPPKPPVAHVPRIYRFTATALGAGMWFFLMYRAKKDGAVLLGLKHPWDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYU7</accession>
    <name>S0DYU7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427714.1">
        <property type="nucleotide sequence ID" value="XM_023574341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYU7"/>
    <dbReference type="STRING" id="1279085.S0DYU7"/>
    <dbReference type="GeneID" id="35396073"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02591"/>
    <dbReference type="HOGENOM" id="CLU_1421511_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT65633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="191" mass="21764" checksum="AA32DEB39C8EA2DA" modified="2013-09-18" version="1">MRPLPQPPWMRNYRRKVPSIIASIRNLPEGVTPTLESIPQIDESLKATEPFSPFSSLIRDMQETEFERWGPHLEWVIKEDCETLSNASKEQVRDRFSQWASKRSIERDGTGAEDPLAELLPGYRYCIYVDEKCLDTVDQYAAWSRRALKVMKGLSSVSCWMGNANPEAEVEMDIPLSKGVPRNTQAGFAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ65</accession>
    <name>S0DZ65_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428763.1">
        <property type="nucleotide sequence ID" value="XM_023573965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ65"/>
    <dbReference type="STRING" id="1279085.S0DZ65"/>
    <dbReference type="GeneID" id="35395738"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02256"/>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="339" mass="38194" checksum="BB1EE3D65DDC2BEE" modified="2013-09-18" version="1">MSPPARKKRADLGSSGSTSPRVDAESGLLPPEYWSQLPEEESAPGDEDSAVLDNASSTASLTSSILQYRTINGRAYQSERGNPEYWGPIDDTGQEAMDINHHVLTLLLGDKLYLAPVPEDIQTAVDIGTGTGIWAMEFADKFSNASVIGTDLAPIQPGWIPPNLEFQIEDCTQEWTFQPNTFDYIHMRWLVGSIADWKSLFKEAYKCLKPGGYIESYEPSSRVESDDGTVQPGRRPFTIFEENIQREAMREAGFMDIEERDFKNPVGGWPKDPKYRSVGQFMQTAFEQDAQGTVLHMATALGWAEEEITVFTSHFRREIRSPKIHSYFRQKVVWGRKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ91</accession>
    <name>S0DZ91_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429947.1">
        <property type="nucleotide sequence ID" value="XM_023576602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ91"/>
    <dbReference type="STRING" id="1279085.S0DZ91"/>
    <dbReference type="GeneID" id="35408025"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14645"/>
    <dbReference type="HOGENOM" id="CLU_001305_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="888"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1146" mass="127914" checksum="F65D9A80AAB545D0" modified="2013-09-18" version="1">MECLKLSLESVASLHAMNEAELRALVGKGNSSDTDSEEGLRIHIYASYLLFEMCSSDNVLEEAILLTKRKIVDSLPDKRALNEWLDILTALLVMLHHSQQITGQIAETSRRDAMLNDIDLRVRLLKNQAAVSMMRFEQSHIMDDLNLAIAIVERLIPVTDLSKSSRLQNNLGVMLHKRYQKTEAIKDLSRAIDAIRIAISLTPDDSPDLAGRLNNLGLWLSTRFERSDIVEDLDYAVEAAKKAVVLTPEGHQHYAGYLNNLANSHGKRFQRTSTIDDIDRAIEASTRAVKSTSQKHPGFLNSLGVWLCARFEASGELMDLDHSIEAARLAVAITSPSHSDHSVFLDTLGTSLSKKFERTDSVKDLNEALSIFTQCLEVTPSHTQDFASTLNNLGICHGMRFERTGSIADLDHAIERTHESVFSTPQGHPKLPNRLNSLGNQLRARFQRTGAMQDLKHAIDAAEKAMKIAARTHPHYPTYLSSLANKLVLRFERTGKIQNLDRAIELVEEAIQGPLVSHDNVAAYYNNLGSSLRTRYEEVGRESDIARAIEACNKAVGLTAKDHPDVYSYLNNLGNAFGSRFSKTDSLDDLDRCIKNITKAVEAISQDHPDRSIMINNLGNWLDKRFEVTKAASDRYSQIHWFLEAWNSKTGAPSQRIRAAGSAAYVYIQREEWDKASTLLREAVFLLPKVSPRFLSHTDKQSLLSSLSGLTSMAAAAALSANKGPYEALRLLELGRGLISGFVMDVRTDISELKVEYPDLAKKFGRLGDEMGHLQSGIGVSTKEDDLETWQRKQERLRKADEEFDKLLGEVRGRIGFETFLLPPTEAELLAAATPEPIVAINVSFYRCDAFIIESTGIRTIELPDLSQRRLRVWASFPSARSELASRLEWLWDALSQPCLSSLGLTSPVLDDNWPHIWWTPTDALSCIPIHAAGRYGEGSTETVLDRTMSSYALTIKSLLHGRKRDIASDREPERRSALLVAMRNTPGSGNLLYAEDEVKLVKQMCPRLDLKPRTPRPSKEGVLTSLETCKVFHFAGHGRLNSMEPSKSCLCLEDWKTNPLTVQDIRGKNLESTQPFLAYLSACRTGTNMESRLSDEGIHLVGAFHLTGFRHVIGTLWEASDRHCVDVAEVFYGTLRDEGMTDMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZD2</accession>
    <name>S0DZD2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429982.1">
        <property type="nucleotide sequence ID" value="XM_023576782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZD2"/>
    <dbReference type="STRING" id="1279085.S0DZD2"/>
    <dbReference type="GeneID" id="35408177"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14798"/>
    <dbReference type="HOGENOM" id="CLU_008976_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="107"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="410" mass="45192" checksum="1A0C1B31A1B83630" modified="2013-09-18" version="1">MLPPALVSVYRKYKKHTNSIASWLASTAKECGYPADLLSNPPAPKQPAPRLKGKARAEAKKKAKVAPQESTPQNEGPRYIIEIKDFVPLAECISAYKKPALSVPAKKVREVLKPHSDPVGSGSSKEAETLTNKFKEVEVYHPSEKFLNAKDIERPGPANNDDVIYEADAGDSVDEAFFAYKLLCEDLNDIRTFITYTWEMHIEAEEGGDSIDPGMMAVVTNTAIEFGSTLAEDVKPLLEKHGGIKAMADDLMSGFLIDQEVDMNKFREQVAKGSVNEKVYAVMSHCCYHTRLSIETLAQVPWKGSAGIYPDGTFSVLDPDTGGEDKSMSQRLTEEQVILAELWTEAMALVYQVPDYPFSDEFIGGVKEFEETKQVPFSVIFAGQVILDVTKSSAVTQSLQSTLFSSESRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZI3</accession>
    <name>S0DZI3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_14599</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430026.1">
        <property type="nucleotide sequence ID" value="XM_023576551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZI3"/>
    <dbReference type="STRING" id="1279085.S0DZI3"/>
    <dbReference type="GeneID" id="35407980"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14599"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="101"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT67946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="452" mass="51231" checksum="33879164B4B742D1" modified="2013-09-18" version="1">MASHRHLGSLPHILPRLLTYSVRSVSAIPKYPTSGTRKSSTQAVPKPDHHAHTTLEHPLTFQTTAYGLIDQNVKIEEEQIPSYEASRFYPVQIGEVFQGRYQAVTKLGCGSSSTIWLARDLRDNKYVALKIYVHTSRNHREIPVYESMSPILAKSSNPGRNNIRHLLGSFEISGQDGRHKVLVMQPAQMSLRDFKQVFRPDGGFDENFVRGAIQELLKALEFIHEKAQLVHTDIHPGNLLLGLDDDSQLEPRADMEQKSPVARKKVTEDRTIYLSRLMRPKPGPMLLSDFGEARTGTGPFAGDIMPIQYRAPEVIMCITWNRPVDIWSVGLTAWDLLGPKRLFTAKDEDGDMYDAAHLAELIATLGPPPQEFLQRNVERTADFWDEQGKWLRLAPIPKGRSPEELETRLEDSTGLTAFLRRVLTWMPENRPTAKELLRDPWVSGRTEAHRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZQ4</accession>
    <name>S0DZQ4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_02954</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428044.1">
        <property type="nucleotide sequence ID" value="XM_023574745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZQ4"/>
    <dbReference type="STRING" id="1279085.S0DZQ4"/>
    <dbReference type="GeneID" id="35396436"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02954"/>
    <dbReference type="HOGENOM" id="CLU_040082_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF259">
        <property type="entry name" value="OS08G0106900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="172"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT65963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="440" mass="50871" checksum="972463FF6DD5E2C8" modified="2013-09-18" version="1">MYEGYLSQLGLHDDFIYRIIIDDFNDQQLRRSAVIMTFLDCLGRQYHRQPRRRDDPLTRRPYADILADSRAHTSWLLAAPDNNTQAGDSRHQSLELKLMIFLWIMAYGEPQRNTAYRFKVSQSTVSDIFSYLIDFMRYLHTKFVRMPDHRYVSPRIELNTKFCQFNGAIGAVDGTHIPAFIPLAHQQRFWSRKSTISQNIFAAVDFEGRFLYVLAGAKGSINDATLIGYAHNGSFKVPPGRFFLANAGFGSRRGILIPFTRVRYHLQDWGDAAKRPVNEIELYNLRHAQLRTIVEQAFGRCKRKWKIIRNSAPEYSFSNQIKIIYAVTGLYNFLAFEGKEPELGHEEEGLPSWEIRALRRARRRADMVVTGRSGIDMRSLIANWLWSTYQAYLELQNDSESEEIDEEGSVVEEVEDGDEIEVIAEEADQREAISSSQELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0G4</accession>
    <name>S0E0G4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to MSS51 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428289.1">
        <property type="nucleotide sequence ID" value="XM_023575039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0G4"/>
    <dbReference type="STRING" id="1279085.S0E0G4"/>
    <dbReference type="GeneID" id="35396699"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03217"/>
    <dbReference type="HOGENOM" id="CLU_033072_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="2">
        <location>
            <begin position="116"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="277"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="503" mass="57470" checksum="2C20E811B8FA949D" modified="2013-09-18" version="1">MEPTLRKAASSICGQCPATVRRQLASGAAARPWMRISAHHIRRHSTTKDQRRASPTPKNRDFSTSSVTKSEATATITNKSSPSPLRLSQDNLFHPFSKSPVPEFRQRAAFMRQHAYCPHPDHQQTKLPTIAPKPEDPEAAKGTQPPQHVNFECPDCGLPVYCCEEHWMDDYEKHLEVCDTLRQINEDDHDLRSGRVFEEGNLPDLQMEHAAINMTNWDTFMYTREFDAVNSDRQMRQITRLLTYPVTIGSILHELSPYSIKAGERMTTEGLKSFSALRYNLHPPKSGRGTGVGELKPEAPAVRIFILGARAESSLPRPAWVQLAHMFPEARLHLIFVGPESMANRDDEFPLPERTPSNPFGAVVEDRVWYKMKISTIVDYYHTVHQTQHFAPYDPYFDCFVLFHPGLGHPASSHEWEETLPLLLETKIPIISTGYTQFDMERDVEWVNQKSKGEFDILLQPGENVFRSLRWDLNDMDPQDVSCGNWGVWAFRGKRYETATRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0V2</accession>
    <name>S0E0V2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430491.1">
        <property type="nucleotide sequence ID" value="XM_023577415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0V2"/>
    <dbReference type="STRING" id="1279085.S0E0V2"/>
    <dbReference type="GeneID" id="35400668"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07191"/>
    <dbReference type="HOGENOM" id="CLU_567461_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="486" mass="55648" checksum="6D7427105F7DDBE5" modified="2013-09-18" version="1">MDEIYYKIAEFNSRRIVQTHDVLSFKFSELWSRDDTGIVDYHEGVTTIPDVASWLSMETRTGTTGPESLILRLIWPKFILDDNCVELPEDAKNQILDKFGLELAYNYFSSCVAGVNAFPEIVKSEANQQAYTFCYAPKLASVWSHTRFRPPSLRPGVTYGMILAGDKEQHYLKKLLKSKSKWSLSTASHAMFPAFLFAFMFHGEIEVTQNNMKPGIQQIEARTGYSDFKTERKHIAAGELGTLSAQMSGFAVRLASTERKDKTLQKLLEFVQQRLSVGHSSNPEADELMKNHVGVLQKRLMMQAMDREYTLKRVQIQIDVLNNLISENYSLSNYIISISTLRDAASMKTLAFVTMFFLPGSFISALFSTDLFDWDSAQADGGDIGVKTTPQFRLYWAVTIPLTLITFILYFMWAEFSSFDRSQRRERRRWGFPRTESMKAQDQTRSPMQVLKDQRERVSEAYAMAKRRQTVFGQGDKDESIGARNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>S0E131</accession>
    <name>S0E131_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Probable acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_03424</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428479.1">
        <property type="nucleotide sequence ID" value="XM_023575270.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E131"/>
    <dbReference type="GeneID" id="35396906"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03424"/>
    <dbReference type="HOGENOM" id="CLU_000395_5_1_1"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="18">
        <location>
            <begin position="62"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="220"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="16">
        <location>
            <begin position="697"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1523"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="20">
        <location>
            <begin position="1865"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1222"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT66398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2284" mass="255986" checksum="D5AF5443039AC3D1" modified="2013-09-18" version="1">MTEISAGAQEGANGRSVPYVNGKASYAEKFHIADHFIGGNRLENAPPSKVKDFVGQNDGHTVITNVLIANNGIAAVKEIRSVRKWAYETFGDERAIHFTVMATPEDLQANAEYIRMADHYVEVPGGTNNHNYANVELIVDIAERMNVHAVWAGWGHASENPKLPESLAASPNKIVFIGPPGSAMRSLGDKISSTIVAQHAEVPCIPWSGTGVDEVAVDDKGIVTVADDIYAKGCVTSWEEGLEKAKEIGFPVMIKASEGGGGKGIRKATEEEGFEALYKAAASEIPGSPIFIMKLAGNARHLEVQLLADQYGNNISLFGRDCSVQRRHQKIIEEAPVTIAKPDTFKAMEDAAVRLGKLVGYVSAGTVEYLYSHADDKFYFLELNPRLQVEHPTTEMVSGVNLPAAQLQIAMGIPLHRIRDIRLLYGVDPKTFSEIDFEFKNEGTSMSQRRPQPKGHTTACRITSEDPGEGFKPSNGVMHELNFRSSSNVWGYFSVGSQGGIHSFSDSQFGHIFAYGENRSASRKHMVMALKELSIRGDFRTTIEYLIKLLETEAFEDNTISTGWLDELISKRLTAERPETMLAVVCGAVTKAHIASEACMTEYRAGLEKGQVPSKDVLKTVFTIDFIYEGYRYKFTATRASVDSYHLFINGSKCSIGVRSLSDGGLLVLLDGRSHNVYWKEEVGATRLSVDSKTCLLEQENDPTQLRSPSPGKLVKYSVENGAHVRAGQAFAEVEVMKMYMPLVAQEDGVVQLIKQPGATLEAGDILGILALDDPSRVKQAQAFVDKLPAYGEPVVVGAKPAQRFSLLYNILHNILLGYDNSVIMANTLKELIEVLRDPELPYSEWNAQFSALHSRMPQKLDAQFTQIVERSKSRHGEFPAKALTKAFNKFLEDNVDAGDADLLKATLSPLTEVLDMYADGQKNRELSVIKGLLEQYWEVENLFMNQPQEDAVILQLRDQHKEDIMKVVHTVLSHSRVSSKSSLILAILEEYRPNKPKAGSIAKNLRETLRLLTELQSRPTSKVSLKAREIMIQCALPSLEERTAQMEHILRSSVIESRYGETGWDHREPSLEIIKEVVDSKYTVFDVLTMFFAHDDPWVSLASLEVYVRRAYRAYILKQIEYHQDENDAPQFVSWDFQLRKLGQSEFGLPLQSAAPSTPATPSGGEFNFKRIHSISDMSYLTGKWEDEPTRKGVIVPCKYIEDAEDLIGKALEALALEQKQKKKNTPGTPGLIPDLSGKRKPAQPKQHEEELSAVINVAIRDVESRDDREALEEILPIVEQFKDELLARGVRRLTFICGHSDGSYPGYYTFRGPEYKEDDSIRHSEPALAFQLELARLSKFNIKPVFTENKSIHVYEGMGKNVDTDKRYFTRAVIRPGRLRDEIPTAEYLISEADRVVNDIFDALEIIGNNNSDLNQVFINFSPVFQLQPKEVEESLQGFLDRFGIRAWRLRIAQVEIRIICTDPQTGEPYPLRVVITNTSGYVVDVDMYAERKSEKGEWVFHSIGGTHEKGPMHLMPVSTPYATKNWLQPKRYKAHLMGTQYVYDFPELFRQAIQNSWVKAVKAQPSLASQQPKTGDCISFTELVLDDKDSLDEVNREPGTNTCGMVGWIFRARTPEYPNGRRFIVIANDITYKIGSFGPKEDDFFHKCTELARKLGIPRIYLSANSGARLGLADELMGHFKVAWNNPEKQDSGFKYLYLDEETKTRFEKDVITEEVSEDGEKRHKIVTIVGKEDGLGVECLRGSGLIAGATSRAYNDIFTVTLVTCRSVGIGAYLVRLGQRAVQIEGQPIILTGAPALNNLLGREVYTSNLQLGGTQIMYRNGVSHMTANDDFAGVSKIVEWMSFVPEKRNSPVPVSPSVDDWNRDITYFPPQKQPYDVRWMISGREGENGFESGLFDKDSFVEALGGWAKTVVVGRARLGGIPMGVIAVEVRSVENITPADPANPDSIEQVSNEAGGVWYPNSAFKTAQAINDFNNGEQLPLMILANWRGFSGGQRDMYNEVLKYGSFIVDALVKYEQPIFIYIPPFGELRGGSWVVVDPTINSTAMEMYADTEARGGVLEPEGIIGIKYRKDKQVQTMARMDPTYAGLKKQLEDSSLSTEETDEIKKKMAIREKQLLPVYAQIAVQFADLHDRAGRMKAKGVIRDILEWTNARRFFYWRLRRRLNEEYILRRMTSTIISTSHSQTATKNTETRDRYLHLLRSWSGIVDWEKNDQAVTEWYETERKTISEKVETLKSEVLAAEVASVVRGHAKAGWTGVREVLRVMPVEEREQILKYLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E143</accession>
    <name>S0E143_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430634.1">
        <property type="nucleotide sequence ID" value="XM_023577583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E143"/>
    <dbReference type="GeneID" id="35400819"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07342"/>
    <dbReference type="HOGENOM" id="CLU_522798_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="331"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="563" mass="62461" checksum="EAE821DEA11905A5" modified="2013-09-18" version="1">MHSPEPELSVSTARIKMTPLSEQPVFKELITLLVKLSASDDDPNYPNFEKCQAANCRTGTKGKQEEAKAVWNKLMEKETFSNEVEFYSTVKEFLPLVHCKRHNSGGFLEECFGDWERFRTKSSGYASYEVSLPSTPTQDQVFESPTVGYGTPLSSPLVDDGTPATSEKSLASSFDSFILSTPSRMDHHNPLSTIEYTSTSDESPRYVPPFPLGINSTPDRAVDVGQQDNIVPSITEVNVVTLRDPPKSLPIHSRQDVAAEQPDMVESIMDETVMKENDSDDEPRLVHPQFSGLGLKRNGTLSDQAAIVMELRKPLTHAQAGEGKVYVLKHREQKDLFKIGWTATTVNTSLSRPNNCYGASCETKPVYESPNLFNGAPKAHRLVHLFLRDINVRVKRCKKCGQGHKDWFEGGEEAIVDAVRVMEGFLRMPAYELKEKGELTDEGKAMVKNMCDVTLKSFQRNQESDGIPGHITGAESLTIPQTVVPEATVDVPSRQGLVDESSSQPEALAASTDASKELEPPLKANKGGLRKKFKKLCGTMKDKLSKDDYDYPFALLKALQPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1M6</accession>
    <name>S0E1M6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_07582</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430849.1">
        <property type="nucleotide sequence ID" value="XM_023577851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1M6"/>
    <dbReference type="STRING" id="1279085.S0E1M6"/>
    <dbReference type="GeneID" id="35401059"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07582"/>
    <dbReference type="HOGENOM" id="CLU_196969_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT68769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="61" mass="7124" checksum="51F293F197CF1B06" modified="2013-09-18" version="1">MAVRPITGMLRRNLVLDLSIALGSGFVMANFFWYGFHMPRTNARDNYYIKLEEERAAQKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2D3</accession>
    <name>S0E2D3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">FFUJ_07779</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
            <orientation evidence="3">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431031.1">
        <property type="nucleotide sequence ID" value="XM_023578069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2D3"/>
    <dbReference type="STRING" id="1279085.S0E2D3"/>
    <dbReference type="GeneID" id="35401256"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07779"/>
    <dbReference type="HOGENOM" id="CLU_054990_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2900:FF:000002">
        <property type="entry name" value="Mitochondrial intermembrane space import and assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="14" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="208"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCT68951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="345" mass="37354" checksum="3A2666772BDFCAAD" modified="2013-09-18" version="1">MYRTTMRSASRPVIASLRSNTIRAAPRRFNSTATPADKSRSWKSSVARLGLAFGAVYYYNTSPIFADEAISKTVPAPAAFSDDDLPTVDSVLEEKRKQIKAKSEKPADSSKPSKPQQSNTQAAAADGSPAALEEEADQQGAFNPETGEINWDCPCLGGMADGPCGEEFKTAFSCFVYSTEEPKGMDCIEKFQGMQECFKKYPEIYGAELADDEEGAPTPDFGDEQPAPDARKAPATDKAPATDSKSLPGDSSAAAEPDQKAPSRATSNEAEKETLANGSRKVQDVATPIEKPHNPELWQDMHKSEVPVKEVFVEPSQAHDATAANAEIKIIEQEREAKKKAEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2G3</accession>
    <name>S0E2G3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to 6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431099.1">
        <property type="nucleotide sequence ID" value="XM_023578264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2G3"/>
    <dbReference type="STRING" id="1279085.S0E2G3"/>
    <dbReference type="GeneID" id="35401430"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07953"/>
    <dbReference type="HOGENOM" id="CLU_015774_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="643" mass="71885" checksum="BBF9D60CC771F594" modified="2013-09-18" version="1">MPVLGATPMQVAPRQRAPRQTSSCLECRRRKQKCSQSQPCTNCFRRFPSPECIYEVKSSKRHHPIASRPKPPLVVDVREGPYSHLNPASIQDALYYLEDEKSPSSSATSPSTSVATSATQPRTDLWLPYKIHSSANGDDDDTIAQSVRIITEKSTIKAKLNYSKERVTEILGSQDHDERYNILPPVDGSAVQLEYLPMKPTKLNKELVRIHLQLLSRFKCAVDGNPDPANEFMNFWIPCTLQDPLLLQIVLFTSSCWLSETRHFSKALQYAHKHQVYRMLNSQLTDQQAQTSDTLVLGVVQMIADSWYWGATHDLKAHLSGLRGMINLRGGLSQLGLRGYLAKMVLIHDIVMALAHEIKPSMYGHPGFEFRDSRSMPFNTAFNTPFISNWQSFKECSNSLQLHPSTAQILDDMRGLFSAVLALPRNPSSEHVQRVLSTAQWFHKRILDLPEDTPSLQSPRPSQSSRASSVESPGSSAGSLRSDKSSSPSLLPDIMYRVIRKVALIYCQAILNRSPISSACSEEDIQAIWLSVWHSGLATWKSVLGIFAWVMIALVTNCHKIGPGRLIKTLTMSTMMSIGMENWDVFNHIAKTAFRLQRWLAGGQDHTNDLMGGEKVVDKYGFGMIGALPPVDIPADVESSEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2Q6</accession>
    <name>S0E2Q6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to putidaredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_08013</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431156.1">
        <property type="nucleotide sequence ID" value="XM_023578330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2Q6"/>
    <dbReference type="STRING" id="1279085.S0E2Q6"/>
    <dbReference type="GeneID" id="35401490"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08013"/>
    <dbReference type="HOGENOM" id="CLU_003291_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT69076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="540" mass="57589" checksum="8D1FE358016EA577" modified="2013-09-18" version="1">MAQEYKLKGVSSLDLSAGSKQEVEVEGIENGKVLLVNTGGKTQALGSKCTHYGAPLAKGVLTSDGRITCPWHGACFNAKTGDIEDAPALDHLPVFQVAERDGAVYLTGEESAIKSSKRQPNVKCTEFGSVQDDHVVVVGGGSGTLGVVESLRENGYKGGITVISNEGYYPIDRTKLSKALMTDLSKLQWRNKDFYEGGSIKFVQGEVNNVDFSGRFVTTSEGEKIDYTKLVLATGGTPRRLPLEGFKTLDNIFTLRSVHDTKKIVDQIGEKGKKIVVVGSSFIGIELAVATAGDNDVTVIGMENVPLERVLGEKVGSGLQKALEGKGVKFYMGASVDKAEPSTSDASKVGSVSLKDGTKLEADLVVLGVGVAPATQFLKNNSGIKLEDDGSIKTNDDYSVQGLKDVYAIGDIATFPYHGPGGEGKHVRIEHWNVAQKAGRIAANHIVNPGGKTEHFIPIFWSALGAQLRYCGNTMASGWDDLVLDGSPAENKFVAYYCKGETVVAMASMGRDPAMAQSAELMRVNKMPTKTELQEGISVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2W6</accession>
    <name>S0E2W6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431231.1">
        <property type="nucleotide sequence ID" value="XM_023578419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2W6"/>
    <dbReference type="STRING" id="1279085.S0E2W6"/>
    <dbReference type="GeneID" id="35407810"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14358"/>
    <dbReference type="HOGENOM" id="CLU_665937_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39664" checksum="384E669BCD87349A" modified="2013-09-18" version="1">MAPPTKRDPQIVYADAQFAKCPACGNRSEPLNVPTSSSSTGVEAFIFCMSVMVCACCCIAGMMDSSLAFFCRNCGLRLVSEKNAHSKVKYDESDLVVVSDKTGAKVAKSPLGAPADMNKAWVVNPQKRFTDLNPKRKFGIEKGRYNIPSSFTSLTPEFSTNYTIETPGMASPQPSDKKENQYLQSTSCSWNRHQSGPHFQVLMRSQSLSTEIAQIHLHANTIWDADIKVLNREVTSHKSWSTYKMEAEQELAWDLYGAGTLWHSSQGVLLWQMRKISSDGVGAKGRILCLLDPYDRLVALVWKTKKPGNEGERWWEMRVYIDVSDDFLGEIIASYVAVRVQTERIRQEHVNDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E369</accession>
    <name>S0E369_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to alpha-methylacyl-coa racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430152.1">
        <property type="nucleotide sequence ID" value="XM_023577017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E369"/>
    <dbReference type="STRING" id="1279085.S0E369"/>
    <dbReference type="GeneID" id="35400309"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06832"/>
    <dbReference type="HOGENOM" id="CLU_033975_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="434" mass="47191" checksum="8C1703FB4F1232D1" modified="2013-09-18" version="1">MLTMRRTLVAPLWRSALSRRGNATAATPRLPLSGIRVLDISRVLAGPYCAQILGDLGAEVIKIEHPTRGDDTRAWGPPFAPYKDGRGGEGESAYYLSVNRNKRSVAVSFKEKEGAKLIQTLAAKADVIVENYLPGTLKKYGLDYNTLAKTNPRLIYASITGYGQTGPYSSRAGFDVMVEAEMGLMHITGPRDGPPVKVGVAVTDLTTGLYAVNSILAAVIERSHSGQGQALDVCLSDCQVATLANMAQSVLVTGKRDGGRYGTSHPSVVPYRAFRTKDGDILIGGANDRLFGVLCKCLGQDDWATDERFSTNSARVANRDVLERMIEDITSSKLLKEWLDIFEGTGLAYAKINDIKDTLEHSHVVARDMIKEIEHPACGQLKVLNSPVKYSRTQPSIRTPPPLLGEHTNEVLRDVLGLDTAEIERLRDKKAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3N2</accession>
    <name>S0E3N2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to DNA Polymerase iota (POLI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429399.1">
        <property type="nucleotide sequence ID" value="XM_023576214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3N2"/>
    <dbReference type="STRING" id="1279085.S0E3N2"/>
    <dbReference type="GeneID" id="35406974"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13520"/>
    <dbReference type="HOGENOM" id="CLU_022440_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000006">
        <property type="entry name" value="DNA polymerase iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="565" mass="63160" checksum="772D55D9767D33EC" modified="2013-09-18" version="1">MEPLRKKRPKRDDARTILQFDYDCFYAQVFENKDAKLKKLPLGVKQKNCLATCNYNARARGLTKLMSVSEAKRLCPELVLVDGEDLTPFRDMSKTLFNFFKTFSWNRKVERLGFDEVFMDVTDIIEYNLSCLNRTSLEESFFCLSKSDPEQGFHCDVTRIAGCVEGLAISTPDLSNPAYMRLTLGSHFAQFLRQQVEEKYGFTSTCGISTNKMLSKLVGSKNKPRNQTTLMAITEDEVIAFVDTHKLRRIPGLGLKTVQVLGTHAGADMSKGVSGIPELSDNPVTVAEVRLHPDISPGAIEKLLTGPGSEKGVGVRIWSLLHGVDATEVKEASDVPTQISIEDTYKGLNTLAQITEELHKLSCSLIRRMRTDLLVPDDGADTPGAQKWIARPKTLRLALRTWAYLHSAQGQNYSRVSRSGSLPHFIFDSKDDIAHIAERLVSEALLPLLRRLSPEKGQRWNLQMLNICVANMVVGAADDKSGAGRDISVMFKRQDEVLKPFQVMEDKHVAQSEEITQTVLEGDGDDEEDNDWDMGDNALCPLCGHCIPLFAVSAHQRYHEMEGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3S1</accession>
    <name>S0E3S1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429444.1">
        <property type="nucleotide sequence ID" value="XM_023576270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3S1"/>
    <dbReference type="GeneID" id="35407024"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13570"/>
    <dbReference type="HOGENOM" id="CLU_110315_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="135" mass="15175" checksum="E84438D6BD106581" modified="2013-09-18" version="1">MGKSLMDKIQAKLELFRLEQRYTRRRHRRSTFVSNAVYVDGEYVYQTPNSTGSSSGSSNIDALHGDKAGVGSMPAPSSVVIDEHHFPSEVQHQQQPPMATAERKRLNRFSSIPHFGGSGNKQMPSIQERRSSMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4Z4</accession>
    <name>S0E4Z4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_05750</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431911.1">
        <property type="nucleotide sequence ID" value="XM_023578997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4Z4"/>
    <dbReference type="STRING" id="1279085.S0E4Z4"/>
    <dbReference type="GeneID" id="35399229"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05750"/>
    <dbReference type="HOGENOM" id="CLU_010353_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000046">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="15">
        <location>
            <begin position="650"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="16">
        <location>
            <begin position="801"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT69831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="916" mass="100826" checksum="026286A2AE244736" modified="2013-09-18" version="1">MSYGKKDEDADLGLVKVDRTQVFQEARLFNSSPIQPRRCRILLTKIALLLYTGEKFPTNEATTLFFGISKLFQNKDASLRQMVHLVIKELANSAEDIIMVTSTIMKDTGGSTDAIYRPNAIRALCRIIDATTVQSIERVMKTAIVDKNPSVSSAALVSSYHLLPIAKDVVRRWQSETQEAAASSKSSGGFSLGFSTSSSQIPMNHSTMSQYHAVGLLYQMRMHDRMALVKMVQQFGAAGALKNPAAIIMLVRLAAQLAEEDVSLRKPMMQLLDGWLRHKSEMVNFEAAKAICDMRDVTDAEVAQAVHVLQLFLTSPRAVTKFAALRILHNFASFKPTAVNACNPDIELLISNSNRSIATFAITTLLKTGNEASVDRLMKQISTFMSEITDEFKITIVEAIRTLCLKFPSKQAGMLTFLSGILRDEGGYEFKRAVVESMFDLIKFVPDSKEDALAHLCEFIEDCEFTKLAVRILHLIGLEGPKTAQPTKYIRYIYNRVVLENAIVRAAAVTALAKFGVGQKDSEVKSSVRVLLTRCLDDVDDEVRDRAALNLKLMNEEDDEMAARFAKNENMFSLPYFEQQLVLYVTSDDKSAFDSPFDIAKIPVVTREQADAEDRSKKLIATAPTLKAPKVGPTKPTGAEAVASASAQAQRYAQELLEIPEMKEFGSVLKSSPVIELTEAETEYVVSLVKHIFKEHIVLQYEVKNTLPDTVLENVSVVATPVDEEELEEVFIIQAEKLATDEPGKVYVAFKKVGGEASLPISTFSNVLKFTSKEIDPSTGEPEDSGYDDEYEVAEFDLAGSDYVIPTFAGNFSHIWEQVGASGEEVTETLQLSGMESIADATEQLTKALSLQPLEGTDVPVNQTTHTLKLLGKTVGGGRVVANVRMAYSSKTGVTTKITVRSEEENVAALVIASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4Z5</accession>
    <name>S0E4Z5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to isochorismatase family protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_07590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430857.1">
        <property type="nucleotide sequence ID" value="XM_023577859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4Z5"/>
    <dbReference type="STRING" id="1279085.S0E4Z5"/>
    <dbReference type="GeneID" id="35401067"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07590"/>
    <dbReference type="HOGENOM" id="CLU_005335_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057088">
        <property type="entry name" value="GLRG_09195_Thiored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24470">
        <property type="entry name" value="Thiored_Isochorism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="545"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="817"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT68777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="933" mass="102764" checksum="4AA1F9BF62C36631" modified="2013-09-18" version="1">MFPFDQASLPQITTRKALIGVDFQHDFISKDGALPVHEPEDFVDQTIKLAQAFRGVGDVVWVQSQFSETRPVLEEQILVSDIAPKTPRASKRGRPNIPIQPIDADGPPDEEAFLSHEVATCVKADTPGCRIASAIEDSLPKTDTRLTKSHYSAFQSTHLLRILRAKMVMELFICGSLTNIGVYATALDAAGHGMAITIVDDCCGYRSESRKTSAIASLIELTGCEIASYDEVMEVIQPKPKPKPKPPKSRKPPSSSKVQEQSQTAKSDLSKGEGREKSTTPDFVKDMTSLRLASNPPSPASTPTQPQPKALSTSAAEHHESEVSPESKATESNGVNQIKSTGAPNGIHESNKAKDSPIKAGPDSGLLDHTSKDHEESTNIDSQHNTTQSPDQVIEPSPPAETSQKEEQTIASPPAQPTSKHEAQTMKAQPDKTQEIPEMNKPAAKHDANLRQEGLCEGDTDIIEDVLPEPLLEGIFDKLREEVQWQRMSHQGGQVPRLVAVQGEIGPDGSIPVYRHPSDESPPLLSFSPTVLAIKNETEKRLGHSLNHVLIQYYRDGNDYISEHSDKTLDIVKGSYIANVSLGAERIMTFRTKRRDKDSSQEDVTSPTTSKRVIQRARLPHNSLCRLGLKSNMKWLHAIRQDKRPKKEKSTAELAYEGGRISLTFRQIGTFLNGEETLIWGQGAKAKSPEDAHAVINGQSTEAIALLKAFGTENHLSEFDWDAHYGKGFDVLHMSNAPRLFTCSDPTINMRIALMLAEFGVNYAKGSITTGSAAADSENLSVKFVDKDKSTVQGDMAVMSYIDARYGLGRPGSTPQAPKELAIRLTRFQRALAFLDIWKTLPKETQSGKRDTKSLKQELEVWDGFLAEDNAPYIAGVELALPDFAFWPVLHDMVEETGVETLRDQKRLSEYYQKVGERSSFKKVLGKHPPQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4Z7</accession>
    <name>S0E4Z7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_05755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431916.1">
        <property type="nucleotide sequence ID" value="XM_023579002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4Z7"/>
    <dbReference type="STRING" id="1279085.S0E4Z7"/>
    <dbReference type="GeneID" id="35399234"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05755"/>
    <dbReference type="HOGENOM" id="CLU_004083_9_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF77">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="741" mass="82936" checksum="2BF264724D62273F" modified="2013-09-18" version="1">MESQTGTSEVNQPNRKRVITACLTCRHRKVKCDHAQPVCSPCKKGNRVCTYTNPQSTSQTSHLGSGNRVSRSNRQTGQDEIKNRLERLEQLLERALSGGPVLPQHPTDAASNLDHPHSKHQGLISSLNPQSEILSADGYDGALLLEGERGQSRWVSSLHYSLLADEIRDVKMLLGGRSGDAPRESLPTVRSVSPFPFSGSPTNDLRTWAPPSADACLLLLDTFYSNVDPMTRIVHKPTLKRRLIEYIDYTYGLDASSSDDGEFSAAHSGKDIHTFEPLALAVFHSAINSLSAEDVLLQFSAEKEALLSQFQHGVQVGLGRENFLTTSNIEVLQAFVLLLTCQSREDDMAKTWTLLGLAYKMALSQGLHREPSLFTSTGMDVIQVEIRRRLWHQICHLDYRSAESRGQEPTISDEDFTTSLPRNVSDENLVEGSLDETSTTAGFTDMTVHLIRLYGHHCFRRIVRGTYKLERTTKSQEAKNNDNANPVTKLRSLFEEVRGMVDEMVNHFQTHYLQYCSPHIPEQRMAIGLATVVEWRCWSIFWLRTPKQYRESVITPEVRQIILDKSVNLIESLNTMPGDKDAQRFGWHIGGHACFQPIMHIVSELDMPNFDAPNRHALRSRALDALKRTMLARGREATPMWNAMNRIISTCLAKSTSRPFPVTPFQTVRTELPINETTQGLDSSAIAQTPALLPDMPNFGEFASSASLPDPTALGSIEMLEPDIMFDWGFWNIDPTAPGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5G6</accession>
    <name>S0E5G6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_07780</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431032.1">
        <property type="nucleotide sequence ID" value="XM_023578070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5G6"/>
    <dbReference type="STRING" id="1279085.S0E5G6"/>
    <dbReference type="GeneID" id="35401257"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07780"/>
    <dbReference type="HOGENOM" id="CLU_031639_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="D-serine dehydratase-like" evidence="16">
        <location>
            <begin position="275"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT68952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="561" mass="60677" checksum="10158836A32CF1C0" modified="2013-09-18" version="1">MDYSLENHKTYTGKHVSELPTPSLVVNLPVLKTNVETLHRDVEKLGIGFRPHVKTLKSLEVTRLMMADGKYRGIIASTIPEIQGALPLVKEGLLEECLYGLPVYPGILPRLVELRRSLRIMLMVDNEQQVDFLEKSASSKQPWDVFVKLDVGSRRAGVEANSAALNSLVERAQKSSAISIYGFYCHAGHSYGGRSRDEAEKTLNIEVSSVLAAAKLLPSDHQLVISVGSTPTAHVVESLKASMPENIKLELHAGNFPCNDLQQVSTGLVTETQQSVSVAAEVCSVYPERNEALVNAGVIALSREASAFSGFGRVVGSPAWGVVRLSQEHGILGTSEGRKVDEDFEVGQKIQLWCNHACIAAAAFYVYYVVDEQGIQLKSTLLSPSLPRLTIMSYADVAASGPKQSPEEAAAPQPPQVITDESASTASLVDVDMPSVHTVPNDFLEQEIKTETQAARVEREEEAREEKRKRDEAAAKAKSADNWLIQQFSRLSDGSATGLVIANFATVVGLGAYLGYKGWGLYEKGKLDWKAVTLGAGILAGVTAAEGAVGRYLYKGKKGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5U5</accession>
    <name>S0E5U5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferulic acid decarboxylase 1</fullName>
            <ecNumber evidence="1">4.1.1.102</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenacrylate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FDC1</name>
        <name evidence="5" type="ORF">FFUJ_06703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-4-coumarate + H(+) = 4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33227"/>
            <dbReference type="ChEBI" id="CHEBI:1883"/>
            <dbReference type="ChEBI" id="CHEBI:12876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-cinnamate + H(+) = styrene + CO2</text>
            <dbReference type="Rhea" id="RHEA:46920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:27452"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29749"/>
            <dbReference type="ChEBI" id="CHEBI:42438"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>prenylated FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. May form higher order oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family. UbiD-like/FDC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.102" evidence="1"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT67953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5U5"/>
    <dbReference type="STRING" id="1279085.S0E5U5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06703"/>
    <dbReference type="HOGENOM" id="CLU_023348_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046281">
        <property type="term" value="P:cinnamic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033494">
        <property type="term" value="P:ferulate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01983">
        <property type="entry name" value="UbiD_FDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032903">
        <property type="entry name" value="FDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="2">
        <location>
            <begin position="142"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="4">
        <location>
            <begin position="351"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="525" mass="58172" checksum="1FD40EB60E5ACC17" modified="2013-09-18" version="1">MQQLHPTLRNRLLASRGLRRSLSGGNSSSPAHLDFRAFVDTLRENNDLTDITSEVDPKLEVAAAIRLAYEQRTKTPLFHNVKGEKDGLFRILGAPAGFSSDSKYPYRRLAEHLALPKDAGVTDVIDKMLSAKRERPLPPVHVSTGPCKENIIMGGDVDLTKLPAPLLNKADGGNYIQTLGINIIPHPTEPWTNWSIARAMVYDKTRMVGLIMKPQHIARIFEEWKKTGNDVPYAIALGAPPIATMAASMSLRSGVSESEYVGALCGSPLELVKCETNNMYVPATSEIVLEGTISITDTAKEGPFGEMHGYSFLDENSQQPLYTVKAITYRNNPILPVCVPGRANLGPDETHTMIGTLASAEIRHLLQQHGLPVTQVFALFETQVIWAAVQVDRKKLAEMKTNAKDLCTKIGDLVFHNKCGMQIHRLLVVGEDINPFDMHDVTWAFATRCRPTMDEFHFEDVPAYPLVPYMSHGPGTKLTGGKVVANCLLPEEYEGKQGWVTCDFENGYPEDIKKRVLSRRQDFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6A5</accession>
    <name>S0E6A5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable molecular chaperone distantly related to HSP70-fold metalloproteases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430143.1">
        <property type="nucleotide sequence ID" value="XM_023577002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6A5"/>
    <dbReference type="STRING" id="1279085.S0E6A5"/>
    <dbReference type="GeneID" id="35400297"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06820"/>
    <dbReference type="HOGENOM" id="CLU_038782_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24051">
        <property type="entry name" value="ASKHA_NBD_LGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="445" mass="48936" checksum="F4AC769E8B6B84AB" modified="2013-09-18" version="1">MGSTEGLLPDAHAPLDITVLGLNSGTSMDGIDCALCRFRQASPNAPMHLELLKYDEIPLEQTIKKRVMRMILHNNTTPEELSEVNVLLGETFSDAVMQFSQKHGIPLSSIDAIGSHGQTIWLLSIPEKGQTKSALTMAEGCFIASRTGITTVTDFRVSDQAAGRQGAPLIGFFDSLLLHHPTKFRACQNIGGIANVCFIPPDIDGALNTEFFDFDTGPGNVFIDAAVRFFTDGEKEYDKDGEMGRAGEADQQMVDEFLHTHPYFALDPPKTTGREVFRDTIAHNLIDHGLEKGMSPNDIVATITRITAQAIVQHYKRYMPTQYGPLAEIYMCGGGARNPNITEYIQNAFPDTRITMLDEAGIPSDAKEAITFAWQGMEAVVGRSIPVPSRVETRREYILGKVSPGKNYRKLLKKGMSFGGDLEYLPPVKELVNYVGGQVFSTIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6R0</accession>
    <name>S0E6R0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432454.1">
        <property type="nucleotide sequence ID" value="XM_023579657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6R0"/>
    <dbReference type="STRING" id="1279085.S0E6R0"/>
    <dbReference type="GeneID" id="35399820"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06343"/>
    <dbReference type="HOGENOM" id="CLU_036731_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="443" mass="49419" checksum="C1E4760DA79AAF7C" modified="2013-09-18" version="1">MHYVRFLGPPKVIKNRRGTLVQLLFTITTDLGDSFLFPERFLDLQVVAIAASPEGSSTWLLSDPGHLDWEPGMRVAKPALEMPVALERALESGMRVHVCVRASEPVHTAESVPRILALSAEKMRYRKEAAEKGAVMPAWVPLTLTPADNAVSIRRLQLNDTPEGLGTIEIEEEIGESIARHIWDGGVIATCALAGIETAPDCESSQNPCMRTMKNIFTRQKSIRVLELGCGVGILGVGLAAVYPRLQPEGGDCTILMTDLPEAEERARSNMKRLENSHLRFQENPVRMLYENLDWEEGRQGRFGPEVRSGPWDLVMLSDCTYNVDMLPALVETLSAIHAANLTYFPQGEPFTTKVFLATKPRHESEDVLFELMDKESWYSVHKQVLPKPVLGGVPQSVELHLFDKSGLSDGRGEMRGEDKKEEDKGKKHKGKKEKEKEKEAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6T1</accession>
    <name>S0E6T1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432474.1">
        <property type="nucleotide sequence ID" value="XM_023579681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6T1"/>
    <dbReference type="GeneID" id="35399841"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06364"/>
    <dbReference type="HOGENOM" id="CLU_156696_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="133" mass="14390" checksum="BFCFAE44C0579E05" modified="2013-09-18" version="1">MPPILQTIALMARDVVDNNVLRDKALGPSATIRLVAAITTSGWITFGLIIGLVLNTRGKASSFVPEWYLDSNGSAWAKLAVAAWWISIILFWPVICVVHVILAAGRGVRNLFLKCGGKRMQKTETETAGVTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E799</accession>
    <name>S0E799_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432858.1">
        <property type="nucleotide sequence ID" value="XM_023579709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E799"/>
    <dbReference type="STRING" id="1279085.S0E799"/>
    <dbReference type="GeneID" id="35399866"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06389"/>
    <dbReference type="HOGENOM" id="CLU_013635_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039510">
        <property type="entry name" value="Vint_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032838">
        <property type="entry name" value="Vwaint_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF156">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14623">
        <property type="entry name" value="Vint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14624">
        <property type="entry name" value="Vwaint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="75"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="739" mass="80575" checksum="F0ED93C8CABFAD58" modified="2013-09-18" version="1">MVRVPIFRSLVSGSKSTNDESPKEDPEKDQVQPIGTISDKDAILRLEPVPNRKGLLVKIEPPKEPSVKIPHVPCDIVLVIDVSGSMVSAAPVPGESDESNGLSVLDLTKHAALTIIESMNENDRLGIVTFASKAKVLQPLIPMNKENKARSLKNVKSMKPLDATNLWQGLLDGIKLFNTGESSTNVPAIMILTDGMPNHMNPAAGFVPKIRAMGPLPASIHTFGFGYSLRSGLLKSIAEIGGGNYAFIPDAGMIGTVFVHAVANLQSTFATRAVLKLSYTRPLELYETTGPSVDQIVPVYADDSEDSQAELTINLGNLQFGQSRDIFLSTNGLKELEFLNEEKPTRALVDAHLTYVKPGDCLKSRKVLESILSKDADFIAMASNQCNILEYSDLPASEIAYHESRSLICNFISTMFPIGVDGEHGITRGMKNKREELRTWIDTLPAKNFDDEKNKSLMQDVSADEPKGQVSMAIESKEYFNRWGCHFLPSLLNAHTRQVCNSFKDPGPLQYGTESPLFISCRDALDQIFDNLPAPEPSRHVHARGGSRSHGSMASISMSSYRNSHGVCFAGSTVVALASGRTVQIRKLRRGMKVRTPRGSRRVAMVLKTPVESEILCRVGKVLVTPWHPVSSDGKRWDFPANEADGVVMYTGCIYSVLLERDASSSAHAIRVGDMWGVTLGHGLTAGSDVRAHTFFGDYNAVGKGLLSLPRRAHGIVIGGGVERDEETGLVTSFRQPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7D8</accession>
    <name>S0E7D8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432860.1">
        <property type="nucleotide sequence ID" value="XM_023579729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7D8"/>
    <dbReference type="GeneID" id="35399884"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06407"/>
    <dbReference type="HOGENOM" id="CLU_2757838_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="70" mass="7838" checksum="7FD21957EACDA416" modified="2013-09-18" version="1">MAPNAKRRFSLSALSPASRRYNKVMSERPDNRRSIDTTATTSTMGGMPVVEVENHLVDPAYRWTTANRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7H1</accession>
    <name>S0E7H1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_05622</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431797.1">
        <property type="nucleotide sequence ID" value="XM_023578854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7H1"/>
    <dbReference type="STRING" id="1279085.S0E7H1"/>
    <dbReference type="GeneID" id="35399101"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05622"/>
    <dbReference type="HOGENOM" id="CLU_072095_0_1_1"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT69717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="176" mass="19153" checksum="2E7E82C5A7680A67" modified="2013-09-18" version="1">MAQNGMFSANLLSSEVSAALPEGYTLRALRKSDFNSGFLDCLRVLTTVGDITEADFAKQYDDMLAAGSYYVIIIEDTSRGDKPVVGTGALITERKFIHSLGAVGHIEDIAVAKDQQGKKLGLRIIQALDHIAEQVGCYKSILDCSEANEGFYVKCGFRRAGLQMAHYYEGSKGKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7V1</accession>
    <name>S0E7V1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433025.1">
        <property type="nucleotide sequence ID" value="XM_023580207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7V1"/>
    <dbReference type="GeneID" id="35402501"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09027"/>
    <dbReference type="HOGENOM" id="CLU_2622216_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="78" mass="8605" checksum="30B46C632BBB7261" modified="2013-09-18" version="1">MVAEKTNDMKEQAREEAQGSSSNQQRQATPCSKDQDPGLQTRAEALEAQSLARIAGQWPDDEDDPFANITSLEDLDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7Y6</accession>
    <name>S0E7Y6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_05826</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431982.1">
        <property type="nucleotide sequence ID" value="XM_023579082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7Y6"/>
    <dbReference type="STRING" id="1279085.S0E7Y6"/>
    <dbReference type="MEROPS" id="M01.006"/>
    <dbReference type="GeneID" id="35399305"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05826"/>
    <dbReference type="HOGENOM" id="CLU_003705_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061957">
        <property type="term" value="C:NVT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="15">
        <location>
            <begin position="158"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="13">
        <location>
            <begin position="383"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="14">
        <location>
            <begin position="674"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT69902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="985" mass="111007" checksum="1E0C9283222724B1" modified="2013-09-18" version="1">MKNPLISSLRRALCLPFNAPTPAPTAPAPPGHSALTKPGGYDADLPMIRRTFHSGPLPRISSRARASTYGSAPSITTPYQPLRRSQLHSFLSSTFTTAASPRLILTQTLHNSKASSLVPRQQQRNCSCRRAMYRNGNDVASASLDIRRGREVLPKNVKPLHYDLTLEPNFETFKYEGTVIIDFDVVEDSTSIALNTVEIDIHETLVEANGATISSSPTLDYNKDTQTTTVTFDKTIPAGQKARLTQRFTGTLNDDMAGFYRSSYKDEDGNTKYLATTQFEATDARRAFPCLDEPALKATFTVTLIADKDLVCLGNMDVASEKEVDSKVTGKKRKAITYNKTPIMSTYLLAFVIGDLKSYETNNFRVPIRVWCTPDQDLDHAVFSAELAARTLEFYEQQFGSQYPLPKMDMVAVPDFAAGAMENWGLITYRVVDLLLDEKTSSAVTKKRVAEVVQHELAHQWFGNLVTMDFWDGLWLKEGFATWMSWYSSNAFYPEWRIWEGYVTEDLRSALGLDSLRSSHPIEVPVKRADEVNQIFDAISYEKGSCVLRMISKYLGEDVFLKGIRIYLDRHAYSNTETTDLWAALSEASGKDVERVADIWTKKVGYPVVAVTEDEGKGTIHVKQNRFLRTADVKPEEDEVLYPVFLNLRTKDGIQEDLALNTREADFKVPDFDFYKINSGHSGIYRTSYTSERLQKLGQNAKAGLLGVEDRAGMIADAGALAAAGYQKTSGLLSLLQEFDSEDEFIVWDEITLRVGSLRDAWIFEDDDVNEALKTFQRDLVSKRANEIGWDISDKDDFTAQRMKALMFGKAAIVEDEPTKKAAFELFEKFINGDRDAVQPNLRPSVFAVVVTYGGEKEYNDILKEYETAKQSSERNTALRSLGFAKDPALIKRTLEYTLSDNVKTQDIYMPLSGLRAHKEGILALWGWVKDNWDISDVKSFFEQKGTKGFDLELAQSLDSMTAKQNWLARDKEDVKEWLRKNKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7Z9</accession>
    <name>S0E7Z9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_08941</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433103.1">
        <property type="nucleotide sequence ID" value="XM_023580302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7Z9"/>
    <dbReference type="STRING" id="1279085.S0E7Z9"/>
    <dbReference type="GeneID" id="35402415"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08941"/>
    <dbReference type="HOGENOM" id="CLU_064620_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="149"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT71024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="237" mass="26275" checksum="6D28BDD0F9DC578D" modified="2013-09-18" version="1">MASSSTPATPLLYSCIAHNTTILSECTTSASSQTSSLASLILPKIEHTNPQKLTYTHGQHQIHYVSESPSEHRDYPSAGGLTFLVIADSSLGRRVPFGYLFEIRKRFLQQFPESTDFSDMPNYGAASFNSELKSLMIEYGTTSGGRDDAIGNAKREIDDVRGIMTKNIESLLERGERLDLLVDKTDRLGGSAREFRVRSRGLKRKMWWKNVKLMALLALVVFLIIMAIVIAIKNGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E876</accession>
    <name>S0E876_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433135.1">
        <property type="nucleotide sequence ID" value="XM_023580344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E876"/>
    <dbReference type="STRING" id="1279085.S0E876"/>
    <dbReference type="GeneID" id="35402379"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08904"/>
    <dbReference type="HOGENOM" id="CLU_011578_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1057" mass="118640" checksum="1F90AE71E5698E70" modified="2013-09-18" version="1">MLAATRIWTSERLVQSRTGTANVLRSTVSLQSKCEQCRHYSPLVSSSTSSEFRNGRRCGSVRFQQPTSLGRSISWDAKSKASAKKTAKRFNRSVDPSKFTTIDQVAAWANDLFGIRPGANIEDVERSAIEHLFRGDSKANIRKATVTNAHHFSRASTSAASSKDTLFSAVHGQDATFIDPITNRRVSNSTMAGTAARYDAQRDLKPTDFVDVSAEADSTPKYNDLDKYKPTIDTETRQPDEPKYDDLGKYEPVIDERPQEKSTEYDDLDKYGPVKYNEPDGKRPTTAEEDSKQYKDLDKYSSSNLDDPLAKRQLTAEEQSKVYDDLDQYSPVYHNEPDGKRPQTAEELSKNYDDLHMYNKGVYWNEPDGLRELTPEESSKDYKDLNMYGPVAWNEPDGLRRLTAEEESKQYKDLDQYADPFEASQAALKAHEKAQMDRTMRGKPLAPKVDAPVEDFASKYDDLHLYRPYYWNEPDGLREPTQEELSKNYDDLHLYGGIFRWNEPDGLRPLTAEEKSKRYSDVHKYAARDVSPPVDRVHPEEASKVYKDLPAYRKFENADDPAPRIHPEVSSKKYTDLGAYKSFENGDPQTERVHPEVASKQYRDLHKYPSTGFDDIVQAVHPEVLSKNYTDLGSYRHSDFASQAQGYPVQPEDASKVFQDLRKYTGVRPNEPTGKMSVPLDEVARGLREFDSKAGSQDSPDSASYTYSRSPNRSSPGSTETNMDPFGPESADVIRAAVLRRAQEGSEGVENQDLSGKKGQQVKTAHPSELTGNYVRDFPEDFVRSWSRDNSSSKSVLLPSNVSGTSPPVKEGSSSMEDVEPGSMDESFPMDDTRLKTALDRYAAKRIKDPYSHEPQGLQTSYSDECGRPTMPVMEKHYTSKAKESTAKTPEMPAMASYKIVAFDPVLRVMSVAEANSAVGASDRPMPIPDALVKLADPAKFLPYFKSLQEEGYEVVSGSGQMLIFRKMQSADDMVIRGGNSLPSDSIARIWTDSHCKRSKRFAARRWTNPKTKKSTKKRRIGRKILVGTGLVAGSVYAVALLTNSSSTRISDLKPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>S0E891</accession>
    <name>S0E891_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to transcription factor Pig1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_08882</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433155.1">
        <property type="nucleotide sequence ID" value="XM_023580368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E891"/>
    <dbReference type="STRING" id="1279085.S0E891"/>
    <dbReference type="GeneID" id="35402357"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08882"/>
    <dbReference type="HOGENOM" id="CLU_003487_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT71076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="847" mass="94760" checksum="7C51D600EC06E623" modified="2013-09-18" version="1">MSTTQPGMFQCGSCKKNYKRLDHLARHVRSHTQTKPYKCHVCPKAFTRPDLLKRHVAGHGSQAGDSSVAEQPRYMPGRVSKACKACSTNHLRCSDEKPCRRCQEKGIECKWNDSMELDSDFQSEEQQQDDTIFSQDDASSSMAAFPDHTSIGSTSSSSVLEQPSLDMLTPQTSHSLFQNLDPSMNTNIDPLFFPLPDLNLLSGGWANPDANDVDMYTYNQLDDIDLRFLDSYNTSIPFEVRSIQPTPRGAQTPRAASHTDPGEPAAMCTEAFQNSHWKFRPNAKDHAGAEEHNLSLPATDSAYPSPESGVALDSNTRVTSAKLEGPARDRILMMVVNSCRSDHLSKAVASFPSAELLDTLLQYYLTSPVTHATSFIHAASFNPNDKRPELVAAMAACGAVLTSDPALSKLGYAIQECLRIAVAKHWEQDNTLVRDLQLTQAFVITLEMGIWSGLPRKVEIAESFFNPVLTMMRRDGKFKRSVYSQSKTMQSPGLVSREEWFQWVEDESFKRLAFRMLSHDANTSAALLVSPSVSYAEILLPFPEHADLWTAASPEQWNSLKASRRQDEPLFVADVIDDPDILNNHTDSVDIYVAIMAVLSCTWTMCWEYLQLSSLQRSRPRRWNTLVTEMRKDELLKLLGHLKLSLSADTSADPEIQMRLELALLHLHMPFEDIQIFAGMEGPERARAVYPTVRDWVKSEAARHTIFHAAQIMHIAKHSPRGSMRGPMAIILYHASLAFWVYGLLSDQSSLSRALSQNVYLDEPDSIALQRFKGFGQGQPCIRWRTEIQGEGEVVISVPLSQPDKVMEAVMGIVRSNFTGLPVPHLTEKLVQIMGELENSAKRKLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8D4</accession>
    <name>S0E8D4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433228.1">
        <property type="nucleotide sequence ID" value="XM_023580455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8D4"/>
    <dbReference type="GeneID" id="35402279"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08803"/>
    <dbReference type="HOGENOM" id="CLU_2413424_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="92" mass="10199" checksum="0EEC48E62FDFDE09" modified="2013-09-18" version="1">MSPLPDNINMCNGYQPRTRDVQGDGYYHPSEGEYGTVDHSTGFTWWSNPADARERTAVFGIVTGVLVQWLKLIGDHGVSSDMKRNGGHFLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8V8</accession>
    <name>S0E8V8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_07740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430993.1">
        <property type="nucleotide sequence ID" value="XM_023578026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8V8"/>
    <dbReference type="STRING" id="1279085.S0E8V8"/>
    <dbReference type="GeneID" id="35401217"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07740"/>
    <dbReference type="HOGENOM" id="CLU_064787_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31298" checksum="DC89B3195EB88B6E" modified="2013-09-18" version="1">MTNLQKNANVRMLACLLDGDDIIESDYRFLVDGSLAKYVKTAPGIFLCDHHDRAFEPIILRNLFPQFPSGDWNNGHVARNPATGEPSFVKTEIVQFPGVQNCWHSRRFDELDFTRQQRLRQKVHVSTHPDVNAGKPVLVKFAVWPWEVHYVEAETTAYEWLQNIEVVPKFLGHVTEGKNGRVIGFVTEFVEGARPAEPRDIEGCEKALRKLHELGIKMGDTNKFNFLIRDGHGVMIADLEAAEQGCSQDELEEEMKGLKACLEDTSFLGGQYIVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E928</accession>
    <name>S0E928_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to nuclear matrix protein p84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433458.1">
        <property type="nucleotide sequence ID" value="XM_023580732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E928"/>
    <dbReference type="STRING" id="1279085.S0E928"/>
    <dbReference type="GeneID" id="35402030"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08554"/>
    <dbReference type="HOGENOM" id="CLU_017925_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="2">
        <location>
            <begin position="605"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="822" mass="92333" checksum="B64A55E421DE656C" modified="2013-09-18" version="1">MAAQEIDNPAAPAIAAFTTLLKEFLSQAEAAKPTSAIEPALRKSDFDDVSGRVSRTADDVSSPAAEGAASTINKGRQFAIIETAARNIFSQLIATTTIDSPDYVKVWNLLDILSILSDDGQCDPALLFWLAEELLDSQTIAGCRKIFDFLESRRERITANHFKQKQLIILRTCNELLRRLSRAEDTAFCGRVFIFMFQSFPLGDKSSVNLRGEYHVENATTYEATRAEDESKMAVDEPEEQLKEQAESRSTPKSSDAKKADKEEPLSTDELYPIFWSLQEYFSQPKKLFETTNLSSFKEGLAATMKVFQTVHNDSRRSLKRKRESGEEDESSNTFNPKYLTSKDLFDLEISDLSFRRHVLVQALIIMDFLISLSIQARVRLTEALPASASVNKAVMYSDQVLSDEDAEWASDMKKTIADYLRQGADGPYFYRMVETVLARDKNWVRWKIEGCHPIKRDPVSPASFLEAKANVQKMATSKRLRSVPMGSVSLDFLKEEDGEAAMSRLKTKERYELPELDTFKRKIADDDFEIDMPTNDQTKAAAIAGKASKSWRALRIAARSKLAALDKIEDPKKIDIVFEELTEVDDIEDTSEPTASEEDIPSNRDPIIICGITSVGKSTIIRKLMEERKGVFAPVVRHTTREPVEGEVNGKSFHFVKEQEFNQLRDGDRLIESGTRNGVDYGTSFKAIEAISESGKVPIIELDIEAAQYAKDMDFQARYVLVTTSNPELLKQRLKASGKEESAIQDILKKHSTELELHKVDELFDTSIVDDDDVEAVKAIGNYIYGESQGKQDFSEDTAMKDEEENTTKIAEAKEATMTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA99</accession>
    <name>S0EA99_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_09100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433925.1">
        <property type="nucleotide sequence ID" value="XM_023580126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA99"/>
    <dbReference type="STRING" id="1279085.S0EA99"/>
    <dbReference type="GeneID" id="35402574"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09100"/>
    <dbReference type="HOGENOM" id="CLU_184680_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT71846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="61" mass="7231" checksum="2BDC999C49E61428" modified="2013-09-18" version="1">MHLMYTLDAQGNRLYTLKKVAQGQVTKSAHPARFSPDDKWSRQRVTLKRRFELLLTQQKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAG0</accession>
    <name>S0EAG0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to ribosomal protein S15 (Mitochondrial)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433694.1">
        <property type="nucleotide sequence ID" value="XM_023581023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAG0"/>
    <dbReference type="STRING" id="1279085.S0EAG0"/>
    <dbReference type="GeneID" id="35401769"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08293"/>
    <dbReference type="HOGENOM" id="CLU_078264_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="318" mass="36201" checksum="823DB6C637AA9479" modified="2013-09-18" version="1">MPPRIPALPRFSTLNLCLRPAAKPATPNFLPIVQTANLSQREKKRKAKQDPYRWAQAQQRKAANVQRREELARERDEAWGDPVKGKTTPFIESLESAGQEATSRVPVDGSGNPLAEAHELPTSPELRNYFLTDSELTEAVKHAYTLTKPMIGVVESQMEPESGVDKAKQHEQRHQKAIEALRRITSLSNSSAKDRFHANVRRIVEEFGRHNTDLVLKGKPKSIHPNEVEMPPRSGPDTGSSEVQIAILTTKINTLSQALQINRGYKDKHNKRNLRLLLHRRQKLMKYMDRKERGSERWTHMVEKLGLTPATWKDQISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB00</accession>
    <name>S0EB00_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_08651</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433914.1">
        <property type="nucleotide sequence ID" value="XM_023580623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB00"/>
    <dbReference type="STRING" id="1279085.S0EB00"/>
    <dbReference type="GeneID" id="35402127"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08651"/>
    <dbReference type="HOGENOM" id="CLU_001524_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000003">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000006">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="15">
        <location>
            <begin position="696"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT71835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1138" mass="129149" checksum="3A67CC5B5EB4E5A7" modified="2013-09-18" version="1">MLISAAAQPLRGSTPSFIRIARHHAFRRHALRAHVRWLAAAADNVKSNPKGTLALPSEARYNEIGVQQLSSHIFDQIFPDGLKPPPQELVELSRDHLRRHDLLGKNTDKSEPIAFDLPPLQGRTLDEHFHKLGLDCAEPYLAYAKEFARANPPPKPRKWIHQSGWTKYYPDGQTEKVDAPDEEMLSFDTEVMWKVSPFAVMACASSPTAWYAWLSPWLLMETTNDRQLIPLGDPNKAKIIVGHNVGFDRARVLEEYSVKQTRNAFLDTMSLHVAVNGMCSQQRPTWMRHKKNRELRDQVASKTPDHDLAVLMTSGMHDEEELWVERSSVNSLRDVAKFHLNISIDKALRDDFSELDRERILERLDQLLDYCAADVSVTHRIYQIVLPNFLETCPHPVSFAALRHLSSVILPVDKSWDAYITNAEATYHKLNDAVEERLIGLTDKALEIKDEPEAYTNDPWMQQLDWSGQEIKMVKGKRKHDPPRPAARQKKPGMPKWYKDLFQSNDAPINITVRTRIAPLLLRLAWDGHPLFWSDKYGWSFRVPRVEASKYAAKQMVECKFDEKEIHLRDDHAHTYFKLPHKDGPTARCANPMAKGYLAYFESGVLSSEYSYAKEALEMNASCSYWISARDRIKSQMVIYQEDLPHDMQAETGHEGEKPSTNGFILPQIIPMGTITRRAVENTWLTASNAKKNRVGSELKAMVKAPEGYCFVGADVDSEELWIASLVGDATFKLHGGNAVGFMTLEGTKAAGTDLHSRTASILGITRNDAKVFNYGRIYGAGLKFAATLLRQFNPNLSEKETLETASKLYANTKGTKTNRKVLYKRPFWRGGTESFVFNKLEEFAEQDKARTPVLGAGITEALMGRYISKGGYLTSRINWAIQSSGVDYLHLLIVSMDYLIRRFNIDARLAITVHDEIRYLVKDTDKYRTALALQVANLWTRAMFSQQVGIEDLPQSCAYFSAVDIDHVLRKEVDMECITPSHPTPISPGESMDISTLLEKGEIARLDPDIVPDAKHAPRLDQIEYTPRVPIMQGIQESAQETIPFLKAQIVSDDAELREIVKDVQKAKLAAAPKKDKPLSRRELQSVLPYRAYPRLVPMEEPVSVSEALKVKPDAYENRKMTWPKYSGKSWSQNSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB82</accession>
    <name>S0EB82_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431788.1">
        <property type="nucleotide sequence ID" value="XM_023578844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB82"/>
    <dbReference type="STRING" id="1279085.S0EB82"/>
    <dbReference type="GeneID" id="35399092"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05613"/>
    <dbReference type="HOGENOM" id="CLU_041827_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="352" mass="38201" checksum="6F26A054CFBB0C26" modified="2013-09-18" version="1">MASFARTIKSPYLSPRIRPSMPGRSMSTNSDQANPPQSPRSGEIIGEFDLSGRNTPAIPPQRSSELQDGFFDLDDIEPRTSYFSDDNERSAPGTPSAPSAPSTPRSRSHVRPIAIDLPQIRRFTSAPARTPPEPLSARGDLPGGYFPLHEDPNSRVHRPHPFQHHPDTRMSRLISESGPIYADSPTSHPAQSVVMSHSNTPVASYLAPGFHDHPVPMGKYYPSNYESRNGAQSNLRPPLSGSVSSNIGSDSSAIPNASSLSKQETELRRKLLQYQRDMVTQTSMAANELISSSAKSGDKPGLSLKDLPFRDSRFATPGCQKPLSPRLLPIGSPGPVTPISLETVGNGDYMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC07</accession>
    <name>S0EC07_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434559.1">
        <property type="nucleotide sequence ID" value="XM_023581953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC07"/>
    <dbReference type="GeneID" id="35405812"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12356"/>
    <dbReference type="HOGENOM" id="CLU_612561_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="454" mass="52620" checksum="9D026D6563DB5304" modified="2013-09-18" version="1">MTALEPTALWLPDEILFNILSMLQDSDNIDAISTKEANITLFNACLASRRLESLAQRVLYRRIDARSSKCLLTLGQNHHLCRLVRELYCPYDTEVVNALLHPHFRNYIWLPSSWTVRFPGWLKTEHGRQEYYDQATTFWMQRLPNLNRLTISLNYGMKTLAKLVHKSLNGQPRRFPRLTRIDFKLSPSGLPTCIQPSLILFQLPFLKTVTIDDMQFIARTNSGDLEMPKNACKRLERLDADFSWITPGSLRNLLSVCESLRFLDIKVVTMLSTTCDPFKYCFGDWIQHCHALESLDIQIKASRRWTDGLTGGREVQEHTWAANNIGSLQNLTLLKRFSLSVELRHLTMPPGPSVPTPSPAKLDFELMLPTSIEQFEIRKIGIPNYKAFVRNIRELLQSQRLENLYHVSLAANMKPHHLAQPGWEVRLREPRQSNKVIHLVHEDRKKRVRSSYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECI3</accession>
    <name>S0ECI3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to sec7-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434433.1">
        <property type="nucleotide sequence ID" value="XM_023581794.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0ECI3"/>
    <dbReference type="GeneID" id="35405671"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12215"/>
    <dbReference type="HOGENOM" id="CLU_004694_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="4">
        <location>
            <begin position="424"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="710"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="902"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1294"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1313"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1402" mass="154829" checksum="A00B07679C081B37" modified="2013-09-18" version="1">MAFRRRRGNLSDDTEKRRHTLFEPSASGDPPPPVPSQPDHSDDDGQGPGESSRPQQPRELARESTTSRPEGLPESQTESRPGSRPDTPPIQEENSKHHRFSVLRFRNASDSQLSLRAKQQSEKPPPVPRPPEIITTAPTNDFNGPKKKSSRIGLTARFRRSTDLPREDVNTNNGTGRQKTLRKSFTDDRRRPTLATLEEPESPRPSTTATTSSPNGTILTPPNRPSESSRSDASSNDRLSHQSSSYQSPETTPKKSGPFFRLRRHKKAPEPLFPFAHLQQQGKAPPGISSASSLGISTTPRPASAQSGRTAGGNTTKGDSDLRSGQSPATTLVAPGGIQSGHSSPTRGDLLRGRSSTMSSMGRDSNDDHLLPPTTRTSSSTGRKSFGDLFGLSRLRQNSELSRQGTMTPTTPGSIGSKNNSLQLARDSFVLPERNEDESPAKYLARVEEVASRGIIAATLSKSADPFMTSVLRSYMRSFSFFGDPMDMAIRKLLMEAELPKETQQIDRCLQAFANRYHECNPGIYSSPDQAYFIAFSLLILHTDVFNKNNKHKMQKADYLKNTNGEGIFDDILECFYDNITYTPFIHVEDDLDPTSDRYASHKSRRKPLISSTVNDPAKRAVKEPIDPYTLILDGSLDALRPNLKDAMELEDHYNYLGSATSLNLKDLQKTFFRTGVLQIVSARSRPDAFMTEQTASNPAEAHPGIVDIKVTKVGLLWRKDAKKRKARSPWQEWGAILTGAQLYFFRNTGWVKSLMHQYENHIKAGHDGTPLIFTPPLQEFKPDGLMSTYAAVALHDTAYKKHKNAFVYVRQGGLEEVLLADNEEEMNDWLAKLNYAAAFRTTGVKMRGVIGGNYDGQSRRGLRRLDSADAATLIQTPTGPVSIARSRIDHKMAEDISAARRDVMKQKIAEADEHVQEIQKQLEHQLRNARHLLILAPIQPRTREQLLSAAARISAQLKWTRQDMWKHKCHRDILIQDLEEEHPSSTFTPTKQQSNRLSQRTGSPTPRGNVGRRGSRSTHHSGTEAGPRTPTESQVVQVPNTAEVTEDVDSPLDQVFTTPPQSATKRRHSSRDLSFVRPEAASTRHGSISSIAQSPIASLPSTPLVKPPSAQDESNKPPLRKEDDGNHDPDADEQDFLEQAGLLEQRPSRDPTDKATVSTGADVPGESGTSTDKGDRSKIRRSLQRTLREGAGHLSHHRGSRKGKEVAGSGEESTQEHQLSRGTGSFVVHGKKASVINFGDGLQNMTHDEKIRARKSSQQQDPPLSPMPSGPEDEDFYSAVGVPVESSERRESIASASTATARSFRELHRKYSTAQAARSTSAGGRLTIPSDTESEVAVSFSDGRRSPLPPMETETDEESDGTGLRRGRSIKKDDLDSRDSDSESLQDIEQLPSRPVQPVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECN1</accession>
    <name>S0ECN1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_06084</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432217.1">
        <property type="nucleotide sequence ID" value="XM_023579369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECN1"/>
    <dbReference type="STRING" id="1279085.S0ECN1"/>
    <dbReference type="GeneID" id="35399561"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06084"/>
    <dbReference type="HOGENOM" id="CLU_038395_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT70138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="225" mass="24906" checksum="AD780C20D83D5B51" modified="2013-09-18" version="1">MSNADQSPCRILVMASGFGSNFQALIDAISTGSLPNSCIISLIVNRRNAYATARAEKAGIPWQYFNLISHGFLGKGESDEQKVTEGRRKYDAALAEKILSADEKPELIVLAGWMHVFSTAFLDPIQRAGLNVINLHPALPGEFDGANAIERAYDEFKAGRLTRSGIMAHYVIAEVDRGTPILVKEIEWKGEDLEQYKEKVHSHEHELIVNATAKVAQETVKNRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECT4</accession>
    <name>S0ECT4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433706.1">
        <property type="nucleotide sequence ID" value="XM_023581036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECT4"/>
    <dbReference type="STRING" id="1279085.S0ECT4"/>
    <dbReference type="GeneID" id="35401757"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08281"/>
    <dbReference type="HOGENOM" id="CLU_1981765_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="126" mass="14260" checksum="79C059F4C258C5E2" modified="2013-09-18" version="1">MHSSPDSDSELPYIEPPSNEALKPIRKPPPYTGTPLVLFLSDIKTPFPELLLSFMHRRVRVRKDGTVKVTTKAELPPGFIVTEDEGSKNRIMKPDEVPRMGDLSRLWKYRNGQLPDSFKSVLTDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDB1</accession>
    <name>S0EDB1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to mouse T10 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432457.1">
        <property type="nucleotide sequence ID" value="XM_023579662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDB1"/>
    <dbReference type="GeneID" id="35399824"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06347"/>
    <dbReference type="HOGENOM" id="CLU_047037_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="362" mass="39954" checksum="65C1E8FAC0B9D3B7" modified="2013-09-18" version="1">MCIVLLTTAHPDYALIAIDNRDEFILRPTSRPHWWTHGTSGRPVLSSRDLQRAEKGTWMGISKDGLMAVLTNYRETDVQDQNHPIHAAKSRGGMVTAWLGTPPEESLKDSVHKLVENDGVKGVGGFSMVCGKLRKQTQGIAIVSNRAGNVEEVPIVAKERGEILGLSNTAFDATGNQEEWPKIAMGKKLFREAIDKSVSDKKSKDDFVSDLFDVLSHDTLPRNENASLVEYIHELKKSVFIPLIGDEKHRKAMEAAMAKGPGEWTDDQAAAEELMSEARPDPSTTPIMGFETGMYGTQRQTVVLVDWEGNVTMVERALWDGNGNAVPKGEGDFKFEFEINGWNDEFCNGSTNGTNGETNGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDE4</accession>
    <name>S0EDE4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434718.1">
        <property type="nucleotide sequence ID" value="XM_023582140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDE4"/>
    <dbReference type="STRING" id="1279085.S0EDE4"/>
    <dbReference type="GeneID" id="35405979"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12523"/>
    <dbReference type="HOGENOM" id="CLU_1326465_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485799" evidence="1">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="207" mass="22678" checksum="5FCD6F2DF9030504" modified="2013-09-18" version="1">MKLLPPILLAFNSVTAAFAAGPVNGTALPKNWGYLAFSLQPNLALIAPSLSQVWVKPVDPALNKQDLSFWFSVNPTHTYADPPKDIEVLLVPGGPGSRMGNIDEVIAFVKKTYPGLKYLMYWGRDRSQSWSIGRQKSHDEQKGLENSYRDGSGCEVGITSEVTSGPDLIFAFIEEVYAIELNRVKDACDDSFAEEHQVPPSGDCSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEA1</accession>
    <name>S0EEA1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to transcription activator amyR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434250.1">
        <property type="nucleotide sequence ID" value="XM_023581570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEA1"/>
    <dbReference type="STRING" id="1279085.S0EEA1"/>
    <dbReference type="GeneID" id="35407280"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13826"/>
    <dbReference type="HOGENOM" id="CLU_016574_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="668" mass="74634" checksum="3FDF8A8BC7837D10" modified="2013-09-18" version="1">MSTASKSAMTAVKRACDGCHRRKVKCDSGITCRNCATAGIECTYLAIPQKKGPKGSRAKVITELRDNQRQASLAAKVQNRLAGQTVDTTIPALNPTAGMLSNDLIKACVNYYFENAYSTLPFLDQNQIEHMMLNMEVGRDRYCLFAALCAYVVLQPGMMLPASSAEESFSLQNHPGANIAASSLLLEECLRVRKGSDYFETPNFNIMVTNIFIYSCIKIIDGPDRAWYYLREATTMALLANMDKEENYSQFSQAEAVRRRRFFWFLFATERVYFFNRRRPLSLYATIAPSQMHDDPNDALYPELQTFFIMCNIFRPMDDSFLAAWRKGCDHLDCHQITGLKNHLKEWQATNPYHPDTAYMASQQFLNNAIWQLNNNQNQYHSDLARQMTSKMASSFAGQPLELAKSCLFPKLFEICLNLTTYLANMPSDRHPLAVGPHQWLRDLYASLDPARNGDFAFTPLLLAKVNEILPRLADPQLRNAPENGSFHMSADIFDGFGNAGMASMPQMNDFNQGMVVDENETKYDLSGSSPDTIPNSNYSNGTPPGTQPGSDIASAFVGSPANVMSPGIDYNVANVGMGGFDMSEMGMNSFTASQPNPLSNIQHQQRVGSQPPLQGLQNQNVNSSTMNPTINSIYGIQQPQRQNSYQMQNQTPLSQMGSMSDMDFSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEE5</accession>
    <name>S0EEE5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_13760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434310.1">
        <property type="nucleotide sequence ID" value="XM_023581643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEE5"/>
    <dbReference type="STRING" id="1279085.S0EEE5"/>
    <dbReference type="GeneID" id="35407214"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13760"/>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="34"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT72232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="329" mass="34431" checksum="ECA8F7F41AE42A43" modified="2013-09-18" version="1">MQSFARATRASALQNVGRRAYSSSQYAQTINNLRINADTKVIYQGFTGKQGTFHAQQAIEYGTKVVGGTNPKKAGQTHLGLPVFKNVGEAVKETGATATGLFVPPPLAAAGIEEALEAEIPLVVCITEGIPQHDMVRITDMLKTQSKTRLVGPNCPGIIAPEQCKIGIMPGFIHKRGRIGIVSRSGTLTYEAVNQTTQAGLGQSLVVGIGGDPFSGTNFIDCLKVFTEDPDTDGIIMIGEIGGSAEEDAAEFLKQANTVNGGKPVVSFIAGISAPPGRRMGHAGAIVSGGKGGADTKIKALEDAGVIVERSPAGLGKALYNEFVRRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEL2</accession>
    <name>S0EEL2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432917.1">
        <property type="nucleotide sequence ID" value="XM_023580078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEL2"/>
    <dbReference type="GeneID" id="35402617"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09143"/>
    <dbReference type="HOGENOM" id="CLU_107674_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="152" mass="17880" checksum="9D2E49DF59BD2EEF" modified="2013-09-18" version="1">MYNRYVETGRVHFIRQHSLDAAQHHKAQWDDLVTPRSLGLILKSITTEYKFPLEFPDHITVLYKLLEAPTNESTSLKMEAWILSEQYRRLAARCIDDTAIYDYTTAKKTVLKPFMVEKFQQTFSMQQANQIKYTDQAKQAIEAARELQKKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF54</accession>
    <name>S0EF54_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_09908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435482.1">
        <property type="nucleotide sequence ID" value="XM_023568137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF54"/>
    <dbReference type="GeneID" id="35403375"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09908"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF62">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="56"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="491" mass="54027" checksum="9203A611731FFB41" modified="2013-09-18" version="1">MSTKLSEAYSAAADGKTLELSPSKNTDNEVGISSEVDDPSYDSVQKSLVRKLDMTLMPMVFILYLFNYLDRNNIAQAKLDSLEKDLGLSGNDYSSALAILNVGYMLMQIPSNMILTRVRPSIYIPSWVCLWSVVSAATAACNSFTHLIVIRFFLGICEAPFFPGVFFLLSCWYTKKELALRYAVLYSGLVLATAVSGLLAAGIFAGLGGVAGLQGWRWLFILEGAVTFLLGLVAFVMLPDFPATKSQSWLFTAEEKEVAVTRMARDAVSEEEHDQSVMHGLRLAVTDIKVWAFALLLLSNQSAYGFNYFYPAIVRGFNLGSRTITLVCTAPPYLLGSFISYFIAWHSDRKAERGWHISVAILFAIVGFIISAATVNIPARYAASFLYICGCFGANAALYSWAASSVGQTPTKKACATAIINVTGQLGTIWSPYFFDSNDEPRYTRAMILLLAFAVLEICVCFLLKFILRRANKKIIAEHEGTGRVPTLFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFH5</accession>
    <name>S0EFH5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to 5`-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435587.1">
        <property type="nucleotide sequence ID" value="XM_023568380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFH5"/>
    <dbReference type="STRING" id="1279085.S0EFH5"/>
    <dbReference type="GeneID" id="35403157"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09689"/>
    <dbReference type="HOGENOM" id="CLU_005854_7_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07406">
        <property type="entry name" value="MPP_CG11883_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041821">
        <property type="entry name" value="CG11883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="326"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="585"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="675" mass="75784" checksum="B5C0DB7D828E0D4A" modified="2013-09-18" version="1">MVKDTAPAEAGEPTAEPQVTYASGRVEHQGQADSPSDLRLIHYNDVYHLDPSSAEPVGGLPRFISVCREYQEGEKFKDQPRALTLFSGDVFNPSLESTVTKGQHMVPVLDLIGTDCSCVGNHDFDFGVRQFEHLSSQNKFPWLLANVIDHDIGGDTPIGHAKKTHMITTSNGIKVGLIGLGEREWLETINSLPPNLEYRSATAVAKELVPKLREDGAEIIVCLSHMREPNDNKLAEQTEGLIDIILGGHDHFYAHSLINGTHVLRSGTDFKNLSYIEARRKEDDPSKWDFDIWRRDIVSSIEEDPSTLKKVDELTSKLNQSLARPIGYTATPLDARFSTVRLKESNIGNFVCDVMRQHHGADCTIMASGTIRGDQIYPPGAIRIKDITTCFPFEDPVVLLRVTGQAIFDALENSVAMYPALEGRFPQVSNIRFEFDPSRPRGERVLWAEIGGKPYEPERLYVLCTRGYMGRGKDGFTSLLVKSEGGQAAEIIEEENGILISAMLRQYFMGLLTVGRWKNLAQHWVKVAQKCETPVSPVRTTFNTDFPSLKSVAENLPKDKRTESVTKDAKDPWGRFLKRRFSINMKPHDDNETSDEELHEKDREEEEFEDPDGARLDFEILLMRKFFTKWALKAKVKTSICDPLKEGEYTVDWTTCIAPVVDGRIIMTGASTPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFV1</accession>
    <name>S0EFV1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short chain type dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435959.1">
        <property type="nucleotide sequence ID" value="XM_023568822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFV1"/>
    <dbReference type="STRING" id="1279085.S0EFV1"/>
    <dbReference type="GeneID" id="35402761"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09292"/>
    <dbReference type="HOGENOM" id="CLU_103010_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25420" checksum="BAC79B2EAB73C5DA" modified="2013-09-18" version="1">MAAKSPIVLILGSGPNIGQSVARKFASRGFRVAIASRSQKEADSTDKQLNIKTDLTKPLEVADAFSKVKTTFGTPSVVVYNASAAAFPPADDPLSVSYTDFTNNTAINIHSAFIAAQQAVAGFAQLPESAARTFIYTGNILNVTILPKFLDAGVGKSGAAHMMWAAADAYKSKGYKFYYADERKPDGAPKYRVDGDAHADLYWELSQGKEQGHWMQTFVKGEGYKKFDTLYTPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EG36</accession>
    <name>S0EG36_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433437.1">
        <property type="nucleotide sequence ID" value="XM_023580703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EG36"/>
    <dbReference type="STRING" id="1279085.S0EG36"/>
    <dbReference type="GeneID" id="35402055"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08579"/>
    <dbReference type="HOGENOM" id="CLU_057721_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="202" mass="23002" checksum="AD06EE88EA53E03A" modified="2013-09-18" version="1">MEEQQHIDELLERYLSLLDEYSQLRQNLSRIQSDVFHNIARANFAGERGMRYGQDHYDERMQATRLLAIEQHVSPSPTFSIFPAPEEDNVADKKETSSAEKSDDASTIDAKEATSPTEKKRKQNKNPLRWFGLFAPMPLRTAQTHSVEAVEEIIPRLVSVNAEMLHVEIEVRRARKRRAKAEAAEKKTSQTAVATQPQSTAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EG57</accession>
    <name>ME178_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase FFUJ_09178</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DMATS1 biosynthesis cluster protein FFUJ_09178</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">FFUJ_09178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="ChemBioChem" volume="18" first="899" last="904">
            <title>A Fungal N-Dimethylallyltryptophan Metabolite from Fusarium fujikuroi.</title>
            <authorList>
                <person name="Arndt B."/>
                <person name="Janevska S."/>
                <person name="Schmid R."/>
                <person name="Huebner F."/>
                <person name="Tudzynski B."/>
                <person name="Humpf H.U."/>
            </authorList>
            <dbReference type="PubMed" id="28295904"/>
            <dbReference type="DOI" id="10.1002/cbic.201600691"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Methyltransferase; part of the DMATS1 gene cluster that mediates the biosynthesis of a reversely N-prenylated monomeric L-tryptophan (r-N-DMAT) (PubMed:28295904). Does not seem to contribute to the final DMATS1 product (PubMed:28295904).</text>
    </comment>
    <comment type="induction">
        <text evidence="2">Expression is negaticely regulated by the global nitrogen regulator areA.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Does not alter the amount of produced r-N-DMAT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436064.1">
        <property type="nucleotide sequence ID" value="XM_023568949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EG57"/>
    <dbReference type="SMR" id="S0EG57"/>
    <dbReference type="STRING" id="1279085.S0EG57"/>
    <dbReference type="EnsemblFungi" id="CCT73986">
        <property type="protein sequence ID" value="CCT73986"/>
        <property type="gene ID" value="FFUJ_09178"/>
    </dbReference>
    <dbReference type="GeneID" id="35402647"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09178"/>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000452658" description="Methyltransferase FFUJ_09178">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="28295904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="28295904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="28295904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT73986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="351" mass="39330" checksum="F0BFA40466B4E43A" modified="2013-09-18" version="1">MSQKSPKSGSPRSPRSPQSQGPVATAAQALEVDDLPEGEEDDPGLGEDFESSTASITSSILHYRTINGRTYHSERGNAAYWGSNDERQSEAMDIAHHMFTLSQSGELHLAPLSDNIQKVLDVGCGTGIWAIDFADKYPGCEVIGTDISPIQPSWVPPNVKFEIEDFNQDWTFPPESFDYVHLRYLVGCVPNWDNLFEQAFKVLKPGGWVESFEASAIIESDDDSVKPDSALAQWGPIFIKASKTIGNTFTVVGDNLQRPGIEKAGFIDVEQWDSKLPLNPFPKDPKLKEMGQFGELFSTRDTEGLVLFVANTLGWTPEEVHVYIAKFRREIRDRRNHPYIRLRTVWARKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH03</accession>
    <name>S0EH03_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to isovaleryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433747.1">
        <property type="nucleotide sequence ID" value="XM_023581084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH03"/>
    <dbReference type="STRING" id="1279085.S0EH03"/>
    <dbReference type="GeneID" id="35401714"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08238"/>
    <dbReference type="HOGENOM" id="CLU_2574060_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="81" mass="8806" checksum="BF80558A2BAFE7DD" modified="2013-09-18" version="1">MNQAIAHPLADAYMKLEAAKLATYHAVRLYDESGEVREDKIRVAANSVKYMAAEAAFAACERAVLTLEGSGMRLSMMLRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHA0</accession>
    <name>S0EHA0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_08143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433832.1">
        <property type="nucleotide sequence ID" value="XM_023581190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHA0"/>
    <dbReference type="STRING" id="1279085.S0EHA0"/>
    <dbReference type="GeneID" id="35401619"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08143"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF77">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT71753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="480" mass="53834" checksum="264210456848CE99" modified="2013-09-18" version="1">MTFSYVSDLSTSSNIGIAAFCFLSSWWLGTSFLAWYRLRHVPGPWFAGLSYIWNGWIAYSGKQHHVFVALDQKYGSLVRIGPQVLLTSDVELVKRMSATKSSYGKSSWVDGVRFNPYHETMFAVRDPRQHDRAKARVAPAYSGRDTPNLEGAVDQQVHNLISLIRRRYLSEPASGVFRTLPLLNVLSYFTLDVISKVALGTEFGCCASDSDPYRFYEGLDEHMPLMALTSDVPWIRAIMYSTTFLKYFGPRETDTQGIGPLMKVTNDNVRQRYSQDQTEKTDMLSSFKVHGLSEGNAQSETLFMFVAGSDTTASAIRVTLFYLMSSPRVYRKLKEEIRSTIREGRASSPITAAQARELPYLQAVIYEGLRMRPVTTGQQAKEVPAGGDTINGHFIPGGTSIAINFSAILGSKALFGPDADVFRPERFIGLSASDLAEMRRNVEMNFGHGRWMCAGKPLAFMELQKVYFEVCCKTEFVPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHF4</accession>
    <name>S0EHF4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436524.1">
        <property type="nucleotide sequence ID" value="XM_023569289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHF4"/>
    <dbReference type="STRING" id="1279085.S0EHF4"/>
    <dbReference type="GeneID" id="35403963"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10499"/>
    <dbReference type="HOGENOM" id="CLU_1461427_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="185" mass="20711" checksum="75698C39B0488160" modified="2013-09-18" version="1">MPLDMEPTKLGTSRKLSHTKLSRFALHADKEGLGVLDDILLCLNPVFSLKDVLPKDAVLKLDLPGLGGQNIWAKDASVYLAFLKFITKESKCNFDDYLSLAAVFHTLDCIYLMAPNGEHMAYGKALSREDERVAESHFNDHRAGSKPLIRQSSGDLQKLIEHLSLFFPGTIKKLLVFRRKGLTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHX2</accession>
    <name>S0EHX2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436333.1">
        <property type="nucleotide sequence ID" value="XM_023569067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHX2"/>
    <dbReference type="STRING" id="1279085.S0EHX2"/>
    <dbReference type="GeneID" id="35403765"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10300"/>
    <dbReference type="HOGENOM" id="CLU_055153_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="431" mass="46329" checksum="DE6405C9DDB359D1" modified="2013-09-18" version="1">MSTATTSTSPTDVGQALINALNSPTGNLTRLLLLADEDGNITGKKGSRFILQSNGYLDLRASLVASQNFPLDAPSFETLYPNSSLQSLNNFDPLLYKETETAILDFWNACSDFNQFALSSFWTIFIETQMVCQALIDQLTGAGESSLQGVINTLTSQTYSEPGSENDPEFKSLAQSASEMLLNLSQVVNQRTNSIQALAGTISAQGSKIQATKTEIDAVVEKFGLNDGDHFISTLDETTPMNLIVLNNHFEAALAAKADWDHEMMESSTTISYIWMPVAGWISGSNAIVEKQRDARLAWDNYQAHIAKKSTDANKTAYALVGAVNLLSFQNEALCDKLQSVERALGEIQSTFAAIGSNLGQVATMMAAADGTVRTSLIANQQAIQAGIANAVKEFQNTLSAVNSLVTIDSNFQTTGVTADINAPSVFPENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHY0</accession>
    <name>S0EHY0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Carboxypeptidase M14A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_10647</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436669.1">
        <property type="nucleotide sequence ID" value="XM_023569455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHY0"/>
    <dbReference type="STRING" id="1279085.S0EHY0"/>
    <dbReference type="GeneID" id="35404111"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10647"/>
    <dbReference type="HOGENOM" id="CLU_019326_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485278" description="Carboxypeptidase M14A" evidence="16">
        <location>
            <begin position="18"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="119"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT74591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="423" mass="47592" checksum="F639F8019E6024AF" modified="2013-09-18" version="1">MLFSTICAGLLLPIVAAKVSYDGWKAFSITARPSDKDIPSLLKDIDHVSLSCGQNRNVFEVAIPPEKLDAFKRLGLKTAVVSDNVGAEIAQEGSFGLYKATTKLPGDKAKLPDKSYFKSYHSFEQHLQFLSDLQASFPKNSEVFTAGRTVQNREIQGIHLWGKGDKGRNPAIVWHANSHAREWISGMTVEYMTWKLVQGYQNKDRLVRDTLNNYDVYIIPIANPDGFVYTITDDRLWRKNRQKRAGKKCIGTDLNRNWPHEWDIPGGSSTDTCNETYRGMKAGDTPENKALVKHTKSVAQKNGIKSYIDFHSFSQLILLPYGYTCDTNITDINEQMELAGGVTDAIKQVNDLNFYYGPTCQTIYQTSGGSSDWVYDVAGAELAWGMELRPQRLRGNGFVLPPKQIVESGEEIWAGMRYLFENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIA9</accession>
    <name>S0EIA9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436829.1">
        <property type="nucleotide sequence ID" value="XM_023569644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIA9"/>
    <dbReference type="STRING" id="1279085.S0EIA9"/>
    <dbReference type="GeneID" id="35404281"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10817"/>
    <dbReference type="HOGENOM" id="CLU_070319_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT74751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="239" mass="25692" checksum="83C77FF52DA9CF4A" modified="2013-09-18" version="1">MSPARRALISVTSASATLFDGKETTGLFISEALHPYKVLRAAGFEVDLASETGTYTPDWLSQQPDFLNGEDLAIWNDTNSEFRKKLDNMPKASELDPSKYGLFYASAGHAALIDYPTASSLQNIAAQVWASGGVVSTVCHGPAIFANLIDPTTNEPLIKGKKITGFTTEAENTMKIMGELRSWGSELVEETAARLGATYERAPGIWDDFHIVDGRLVTGQNPASATSTAEAAVAVFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJW7</accession>
    <name>S0EJW7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437013.1">
        <property type="nucleotide sequence ID" value="XM_023569857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJW7"/>
    <dbReference type="GeneID" id="35404473"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11009"/>
    <dbReference type="HOGENOM" id="CLU_015639_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="714" mass="78571" checksum="C82239F02C1F7E0E" modified="2013-09-18" version="1">MAQYEAILSTDTTDLPSGSPEQDMRLEETTPPPPGRYESFREADAVSLPRADTDFEPALLKTAHEENVSGKSQPPGPISWNKYAKHRWWHKIGLLGLITLMAGTLSFATATKVITICSAAIRVSIGLHISLVAAAVAALMLETTGTRFCDVAAVSIQRASGSSPYTILPASLRLTRLSTFGVLHASIMILGTIILVASTFTSTILLTDLKNVNIAGPTQTKLLPIRLGPNTTLSANGVLHYRSSPSANWRFGEMKSGNVASTAEIADTGNTYRVLLPYMKEESRTTLEHYSGPGLVSNFRTVCFSPNLERIRFGLTASKSGLQTELDIRSTKNGPEFLKNWSDSRFTFYAQLPTKWNESDRATLPLSLANNFHAGPRGDLGLQDHPSGRNFTFIPLMLLKSSPILLRGFGHLDLGGETDESEAMDKIDQLKGLKTNMDGRWTIASLKNGTQVLSATLCFVADNAPELYEITMTGMTIPSEPTVGWQRNGTSKSSAQLQKQLGIGVSYKDYRDRHIMQLKEPRNLALIQALLGYSPQGGWATTNYKDLYEEDWIAWWAAHAVHVSLIQDILRVTGDPALAIQALAFRFHSMIFYDSITEFDLYKPVTTISSVEMLISVRWTGLAVVLSLILVHLLLLCSTMVLFQLKTRASGLGNAWQAIAQVVSTETRAVMEEASAVRDKEVEAWARSSGVSRRSYAVSMSDVRNRMEIMEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKG3</accession>
    <name>S0EKG3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to purine-cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_11163</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437158.1">
        <property type="nucleotide sequence ID" value="XM_023570031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKG3"/>
    <dbReference type="STRING" id="1279085.S0EKG3"/>
    <dbReference type="GeneID" id="35404627"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11163"/>
    <dbReference type="HOGENOM" id="CLU_026016_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="494" mass="53713" checksum="D0A2C054288088BE" modified="2013-09-18" version="1">MGKSEKTGVAAADPPVDVSEAESQALSRSTIWLDRLKRWGLETRGMQPVPLEERTDTRFINIFFLWFTMNVNILPIVTGMLGTLGFGLSLKDCSLLILFFSMLCCAFPAYCSTFGSQTGLRQMLISRFTFGYYFIVIMVILNLCTNAGFGIICSVTGGSTLAAVSSGSISSTVGIVIISIIAMVVSFIGYKFLHQYERYSWIFNLVAIIIATGVGGKHLSNQVEQPAASASTIVSYGGVIAGFIIPFSALAADFSVYCHPKVSTWRIFAYTYAGIFFPVVTLMILGAAIGGATPNVVSWKDGYDRFTVGGVMQAMLLPAGGFGRFVAVLLSLSVIGNLAASIYCISLNFQLLAPFMLKVPRSLFTIVYTVVAIPVSIQAAKSFFDSLENLMYLISYWAAGYVAVIATEHFVFRGADFSRYNPDHWDQPTKLPTGLAAIGAMGIAFGLTVPCMSQEWYTGPIAKTTGDIGFEVELVLAALLYVPLRWVELKFRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKN7</accession>
    <name>S0EKN7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to NADPH-dependent aldehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437447.1">
        <property type="nucleotide sequence ID" value="XM_023570318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKN7"/>
    <dbReference type="STRING" id="1279085.S0EKN7"/>
    <dbReference type="GeneID" id="35404883"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11421"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="345" mass="38304" checksum="113630AD88D11602" modified="2013-09-18" version="1">MSSPSTAIPTGSWVLVTGATGFVASHVTRQLLQRGYKVRGTVRDQGKAQWLIDDHFKSYADSGSYELVTVPDISAAGAFDDAVKGVSAVAHIASVLDFDPNPNNVVPQTVAGVTSVLESASKEPSVTRFVFTSSIVAAVFPTPDSDGVVDRNSWNEFAIKAAWAPPPYEPSRAMLVYAASKVAAEQALWKYIDENKPHFVANAICPSGILGEPLHERHATSYGNWIYSLFIEKRGMIDTFQTAFFVDVQDVALLHVAALLDPELKDARLQTWGHKAHWNNFLPILRELRPQRKFIPDYPETFYLKLSTDQSESVALLKKWAGQEDWKPIRQIITEAINNPYWKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKZ5</accession>
    <name>S0EKZ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to 15-hydroxyprostaglandin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437734.1">
        <property type="nucleotide sequence ID" value="XM_023570654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKZ5"/>
    <dbReference type="STRING" id="1279085.S0EKZ5"/>
    <dbReference type="GeneID" id="35405183"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11722"/>
    <dbReference type="HOGENOM" id="CLU_010194_13_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000643">
        <property type="entry name" value="Short chain dehydrogenase/reductase family oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="339" mass="36418" checksum="9BC399067EAE6236" modified="2013-09-18" version="1">MSHSIRGKTAIVTGAGSGINLAFAEQLLNGGCNVLFADLALLPEAQKLVDAYSGGAESKGQAVSQQTDVTNWSHLERMFERAEEEFGDIDIICPGAGVYEPSFISFWYPPGTPQSKDTLHDGRYASIDINLVHPIRTTQLALSRFLRYEKKPRTIVIISSTNAQDTYLSTAIYDATKHAISGFVRAMAKIDQVGVRIAAVALGIIKTPLFMENPDKLATIDTSKDVLVEPSEVATVMVALIERDSICSTIDQARTGPQDIEIKSGSIIEVTKNRARVVNAYHDPGPSGAGAVGSNFATSEYTTLALLLTPGWGDSSVKASSNLSSDHQNKSILAESRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELZ7</accession>
    <name>S0ELZ7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437897.1">
        <property type="nucleotide sequence ID" value="XM_023570844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELZ7"/>
    <dbReference type="GeneID" id="35405355"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11895"/>
    <dbReference type="HOGENOM" id="CLU_040838_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38568" checksum="8E94F9E6DBAA9FDE" modified="2013-09-18" version="1">MADAAVPVFFELSWSILMTICMGNVLLGCLVCGITNWTLLAAVPMFSSAAGAIANGLCYYVYYQKHPAMMLAIASVFADIFWLLQEAGLLFYSYIILKRVLRGTRWRVFMSIFWSGIAGICVVRVVIITFRVKSILAGNEDLLATINHIHIAYFGLIASLECLSAYFLIVLFTSAKTSSAEIARSGGLFQYLARSTEIRVALLALQGTLRAVTHSFKTAGQTAENIATQLDRFFYAVFCLYSMVLYIDLLSSKLKFNGTQDYPSSRDRYVHQSSQPGRFTSTQKDDFAQNRTEHVVGVNGGTRTHKTRNDSTDHIIEGGSSQGDGSINLEDMDLKGNVIKKTVEFRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENX4</accession>
    <name>S0ENX4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to pathway-specific regulatory protein nit-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436521.1">
        <property type="nucleotide sequence ID" value="XM_023569284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENX4"/>
    <dbReference type="STRING" id="1279085.S0ENX4"/>
    <dbReference type="GeneID" id="35403959"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10495"/>
    <dbReference type="HOGENOM" id="CLU_007003_8_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="649" mass="73539" checksum="0C5D16023EAA067B" modified="2013-09-18" version="1">MDPQEARRLVPILPAQQTSGYIFGEDHSPGPSSPPHRLRKRVLVAVACEGCRRKKAKCDGRKPTCSRCFSKSEACSYETPSVPVAVQKKYDILLVENQQYRELFDAINKKSECEAQEIFNRLRSSDQPLAVLESMRQAEVLLPKPSTNTWGSDPRLAFFDQKAFESSVIQVPARPWTTVAGDGIVSELITDFFTWDNSYMFPVLDRITFVDEMRAGDDTEVKWCSPLLVNAICAKRCLMVERGKQFGVMTGRNLSEAFLAEAKSHFESEQGRPSIPTVQALLLIYLTMAATGKDRAGLIYRLTAYEMLKQLRLEARYKTAKNNVPPQTHDMMLTSKTLWGIFLLESRIAYFYNRPSTIPPPQVPKPFLSILTFTHKGNLDVLDRPWKDSSDLVPRPPGVLAAACSFSELLYEIMQYLTTSKFRRGSEEDIHARRLFFSRLIQLKHDIPRQLVVEQNLTPVTCFLRIDENLILYTLLQDMPIDIPFGVPYSSTVKDLCIQHCRHDTEIIGSFIKKWPTNLMIAHQLYISMQTMVPVLDDIAVQDLFTKSCRMAQLSSGSVRLSGVLLQATQAFVWAMEKFIPESARQHLEGLTQETVEKDLPMSFALPPRGEVMEVLASDENDQECSIWNLGTLIEKWAMLSMAGSRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPK5</accession>
    <name>S0EPK5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437356.1">
        <property type="nucleotide sequence ID" value="XM_023570213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPK5"/>
    <dbReference type="STRING" id="1279085.S0EPK5"/>
    <dbReference type="GeneID" id="35404789"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11327"/>
    <dbReference type="HOGENOM" id="CLU_011226_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="CDD" id="cd03038">
        <property type="entry name" value="GST_N_etherase_LigE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="275" mass="30953" checksum="20C27AB23E4000B7" modified="2013-09-18" version="1">MSESSKKIVFYDIAARPPVEKNVFSPNPWKSRFALNFKQVPYSTSWVALPDITKVRTGLNVPACRKFNDGKDFYTLPIIEDPSTGSVVGDSFDIAIYLQKTYPTSGGGDLFPTQTLDFDFKHPYILVPLSEWRDKQNPEYAKFNLNIDAAFTAHVQLGVQGMPFDPASEEESKAEFVRRAGMKQWDDFALVGEARDKVMESLREMLGNLARLFTRDVSGPFLLGDKVSYADMVVGAWLRMLHATLPKDEWAQIAGWHDGTFGKLHEALDAFAEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPQ7</accession>
    <name>S0EPQ7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437616.1">
        <property type="nucleotide sequence ID" value="XM_023570513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPQ7"/>
    <dbReference type="STRING" id="1279085.S0EPQ7"/>
    <dbReference type="GeneID" id="35405058"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11597"/>
    <dbReference type="HOGENOM" id="CLU_001305_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="572"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="884" mass="97488" checksum="599C1FB25ABF27F7" modified="2013-09-18" version="1">MSQQSENRSLLDDLDAFIDMAREVVDVAPADDPDRIIWVHELGNTLRRRFTVTGVLADLEDSIKLGQEAIDTAPNDYIHRGVLLDSLGVHLAIRFAQTGSLADLERAIQVTREAIDVAVDSDDRAFRLTHLANHLGERYEGTGSSIDLEEAIEVAQSAVDLTPLDSPKRPGRLNTLANQLHERYGRTGILAELDKVIDICRGIAKAGVEGSPDQALFKSNLAGHLGDRYLRTGDTNDLDEAIQLAQEALTTLPQSHADIPNLSSNLSIWLAKRYIRNREAKDVEEAIKMGHQSITVAQPGNPSLAQYMSNLADCYWNRHTLTNYMDDFDAAVNLYRSALNHANSNIQTRIAAGKFLFETYAHASQWQHALDASQTTFDLLPQLTPRSLGFADKQRMLGRIVDLACDAAAVKLHAGEKPFLALSVLEKGRGVLPAAIEQIRVDVLDLEEIHPDLAGRFLELSQILDKPIQGGDSVSAQAIANRRGEASAELDSLILEIRKHPGFSDFLESSNEDDVRAAASLGPIVVVNLSKFRCDAILVETHQITSLSLPNLTNDKMNEKESQNSLTSPSMLEWLWDVAANPILQALGIQGPPPGDDWPHIWWIPTGRLGRLPFHAFGHHYLGSTQTVLDRVISSYSSSIRALINGRKLRSDSVQDKAVLVAMEETTAQIKLPFVKEEVSAIVKICKSMNLESRVPEQHKQAVLEELQNCKVFHFAGHGKTDGNPSQSGLLLTDGILTVSELMDINLRKHAPFLAYLSACGTGQVGGDAFFDESIHLISACQLAGFRHVVGTLWEVSDKSCVEVSQTVYESIRDEGFLDRSVCSGLHKAMRQLRDKWLSGPEQCLNGMASGEREDAWTRDILSCDEGDEEMEKLVWVPFVHFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHF3</accession>
    <name>S0DHF3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to tol protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423570.1">
        <property type="nucleotide sequence ID" value="XM_023577783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHF3"/>
    <dbReference type="STRING" id="1279085.S0DHF3"/>
    <dbReference type="GeneID" id="35395515"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02032"/>
    <dbReference type="HOGENOM" id="CLU_002639_8_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="125"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="590" mass="66686" checksum="78526D8FA3B14FB8" modified="2013-09-18" version="1">MAELHWSTNQYIGDLENSWEARKGNFNDGETIQITAPADSLYGAHGFVPLTDVEPASSERNYRVLRKWLSTCISSHQGCRVSHSMTEKSTQETTVLPTRVVDIGDLKEHRSKPRLFISNKASGQYIALSHRWSKSIVTKLKGENLSQYQKELPVNDMPPTFQDAIEVTRQLGFRYLWIDSLCIIQDDEPDWSKESHMMGSIFEEASCTIAAVDSVDDNGVDHGLFLPRDTNSPSVKLTIPYNKEPLSKLSQRVFKTHAAVYVWKMRWLREIPTKKICDKNTITIRPRIVSSRRRIPRSNWHKRGWVLQERCLSRRLIYYTKSKLSWSCFTQSGEEEGGDPQEADRIPLIPLRRESDDSLFNIWQGIVSDYQGCQLTFSKDRLAAVAGISARLEAKFPCKIYAGILFHSPGDAAENLLWYASKTPLRTFNEFHAPSWAWVAFNGEISFFMPTPRGAGELLVDRLDFKIRNQCESVDPSKDCKGTCVSGSVSFEGPAGKLTRGGKLKDLKVAGGPVDPINERKILAKILGHSLMPGMAIPRFDELGSMVRMPYNLPVPDHTEILKDECGCIIGFFIPDLEEELEQATVETYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI20</accession>
    <name>S0DI20_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to MAK21-protein required for 60S ribosomal subunit biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424050.1">
        <property type="nucleotide sequence ID" value="XM_023577706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI20"/>
    <dbReference type="STRING" id="1279085.S0DI20"/>
    <dbReference type="GeneID" id="35395013"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01528"/>
    <dbReference type="HOGENOM" id="CLU_003417_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="592"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="873"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="906"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="942"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="981" mass="108975" checksum="37B38221BAF08B8F" modified="2013-09-18" version="1">MAKPSKKPKGKGPRSSSKGPNFDNSALDNLTSTIDKQLGKRKQPPTKSNGEQHQKRQRNSEGSPGEKSGKIDEKTLLEEIKALGGDESDLALIQDVDSDDEEYTQGPKDSRAVDKSLKDELAAFSKQLGFAEVEMSEASDQEEEEEDDDDAEDNEVEGVDDDDSEEEQAVAPKEPTQKKSNMAFEPRADWHDSELRKLPAPTTDEPTPPRAALDALKQHAQALLEEDATKYRTSVFAQSSHKFLSTIMTSGTLSDKVSALTLAVQESPVHNIRAFDALMSLASKKSRGQALGAIGALVDLLGPGTLLPADRRLRAFHDQPGLVGTLQRNPGKPWAPGNALPGKITPAHLIAWIYEDWLKATYFRLIQLLESWCSDEIEYSRTRALDFVYGLLKEKPEQESNLLRLLVNKLGDRDRKISSRASYLILQLQNSHPGMKPIIVRTIEQDILLHPSQDHRSKYYAINTLNQTILSNKEPSLAEALMRIYFDLFTIILKIGSLGITAPTDSKPGKDDDKKGDVKRNTGRRPQRPRGGKPAKPSASEPETEAADKLVSAILTGVNRAAPFMVGNDAIMESHLDTLFKIAHSGNFNTGIQALLLIQQISSSRSLANDRFYRTLYESLLDPRLVNSSKQALYLNLLLRALKNDVDSRRVKAFAKRMLQISGLHQPSFTCGLLYLVGHLRESFPDLSTLLEEPEESIFDDEPANEKQRYDGRKRDPEYSNANRSCLWEMIPLQCHYHPSVTVYAMSILERNKKSLKPDLDSHSLIRFLDKFVYRNAKVTDSAKGVSIMQPLRATKDVDDIWLGSRGAGGAVPSVNSSAFWKKKAEDVPAEDIFFHQYFQQIDKEGKETKKNAAGNVESDDEQEDEVWKALVSTQPGVDPDDDGSDVGFDLDDSEMASDDDLQALSLDGELGEDDDDDMSVDIEGSDEEMGGALISEDEEGFEVKEAASEKPKSKRRKLKDLPMFASVDDYAELLAGEEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJV8</accession>
    <name>S0DJV8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_00544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424940.1">
        <property type="nucleotide sequence ID" value="XM_023573175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJV8"/>
    <dbReference type="STRING" id="1279085.S0DJV8"/>
    <dbReference type="GeneID" id="35394029"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00544"/>
    <dbReference type="HOGENOM" id="CLU_026654_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT62859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="43014" checksum="F66C86F3AB4F5D2F" modified="2013-09-18" version="1">MCFGSKKETSNDPAPRPAQRPASSQSQGDVKKSKYNPQNDPNQYAGESSYSAPPGPPPDRKQASDFAPPPGPPPGQSSSQQYSAPLGPPPGKAAAQYDAPSYSAPPGPPPGQGDYAPPSGPPPKHDWEVAVPDTSLFPPPPAIFSGYDRSPTSNATEEEANAGEDWCQSYPLTAPINLDQTGKTALRAGNIRLMEPVGFSGKLTWMEPGHWQGWSKKNSPDRCIIGYPPLYSVTEHDPIRLGQPKTIYYEVKLARDSPEVFIALGFTALPYPSFRMPGWHRGSLAVHGDDGHKYVNDRWGGRDFTQTFKRGETYGIGMTLRSVGGPKPQVDIFFTRNGTMTGGWALHEETDAEQDLPVTGLEGFHDLSCAIGTYDGIKFEAIFEPSKWLYNPFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKI3</accession>
    <name>S0DKI3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Meiotically up-regulated gene 190 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_00499</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424982.1">
        <property type="nucleotide sequence ID" value="XM_023573224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKI3"/>
    <dbReference type="STRING" id="1279085.S0DKI3"/>
    <dbReference type="GeneID" id="35393984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00499"/>
    <dbReference type="HOGENOM" id="CLU_002125_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF2">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="305"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="542"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="763"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="709"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1104"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="710"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1156"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT62901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1224" mass="137728" checksum="998A5A7CF9C7F301" modified="2013-09-18" version="1">MSGRDDAEEHRRYTAPYSARHPIPTISKYREERAARQDAAVGKPDPSEAAGSNDYQFQRKSREDDGPHLESVEDEKNDDSRKDENEETGNGEEMTDTSQVGPQSSDPKQRRKEIKKSKRERAEREVTDPVTHLPVTIHDFTDEALKEIDTNEPPFGTTQRTATGSENKNKTDEQLRDEHRDIQQSHDAMGDLFPPPDFDALRLELSSISKRGVTFGLAGVATIVAGAFAVERLVRELVLQGGKTKSSLLVGASLWLILTAATMGAVWFLVVSVREWMSKKVNNIFEDEVWDAHRRGVVKASKKNDTETTVWLNSLIGSVWPLINPDLFASLADTLEDVMQASLPRLIRMVSVEDIGQGSESLRILGIRWLPTGAAARAVDEEGQLMTKKQSENDTEEKDGENSDSSAMIQDGMEAEEGDFINLEVAFAYRTRSSSKSLKERTKDMHLYLAFYLPGNLKIPVWVDLQGMIGTMRMRLQLTPDPPFFSLCTLTFLGQPRVNLSCVPLSKHAINIMDVPFISNFVQSAVDAAMAEYVAPKSLTLDLKDMLAGDDFKKDTNAVGVLVVNIKRGYEFKMGDSGIPLIKEGSSDGYVSVGWAKFGKVMWTTRVLENEMEPVWDETCFVLVTPQELNIDERLRVQLWDSDRLTADDDLGRIEIPIKELMRDDKSNGKMSHRKDGFRALKSGDGMPGKLEWSVGYFSKTRIQQCQFEKQTHDPEIRTMDQLKEKVRESSERKLRETMFKEGKKERDASELEQQTAQELKAEQDAMIISAPPPDGYPSGLFSIQVHNITGLELERLNKRKAENDAEATDEEDSGDGLPSAYCTIILNHRKVFKTRTKPQNSKPFYNAGCERFIRDWREAEVFVTVRDARLKEDDPLLGIIHLPLGEIFRERSQVMGFWPLSGGIGYGRVRISMVFRSVQLQAPRNLLGWQYGTIEVQPAVTVVDCPKELRSSKLKFRTSISSAKMYTEDGADQGTVTWKSKRGRSLALAVAKRYSSCMSIAFREKGFFGDGTTAFAVLWLKDIADEEETELELPIWKGDFQRATACCLEECGERLGTIKLKLTFWSGLGSAHSRWASRDEHLQNVVEVIETARDNLEVGHQEREAGIVESDDSDDEGCSQRVRRAGSIGSNSDSSSSSSDTEDEDGQVSSVPDGSADHKQGPIDQLRDYRRRDKRLHRQHRGLMQWKIPRTAKWIKNKMYRVGDKASGVFDHSSKQPGIETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKK0</accession>
    <name>S0DKK0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425031.1">
        <property type="nucleotide sequence ID" value="XM_023573286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKK0"/>
    <dbReference type="GeneID" id="35393930"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00445"/>
    <dbReference type="HOGENOM" id="CLU_062863_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="331" mass="37538" checksum="C27BF2C589E0C995" modified="2013-09-18" version="1">MMLKYLTKPTRKNISDALLILGVIGSVISVILASIVFIAGTTIIRGDPDHLLWKPLALVSFEGIIPNNDTSHFLVHLNWFASSFGWEHPTAPKGIPKVGITSSGLRYHSNIVNDLNQIATELRLPEDTFNCPKPGPYEDPCGNIFFEAWRSYMASGGLPISSWIVWINIYVALVFSIMDILREWVIPNRPHWMKCRCIIGKRWCPLPKGSREEIEQFDDYVWDKVRLTYWAISAAYFGIAAGHTCINSVFFVRYLGYFEERLPDGISMHGRRRLASEILLWVAFGIKTFGALCMAVRWKLSRRPKGWLDGQSLGRLERTKPNGADGGKYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKR1</accession>
    <name>S0DKR1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_01543</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424038.1">
        <property type="nucleotide sequence ID" value="XM_023577539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKR1"/>
    <dbReference type="STRING" id="1279085.S0DKR1"/>
    <dbReference type="GeneID" id="35395028"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01543"/>
    <dbReference type="HOGENOM" id="CLU_031223_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="15">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="14">
        <location>
            <begin position="143"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT61957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="438" mass="47328" checksum="E1FA38370ADE41B7" modified="2013-09-18" version="1">MAVKKVFARSVYDSRGNPTVEVDVVTETGLHRAIVPSGASTGQHEACELRDGDKSKWGGKGVTKAVENVNTVIAPALIEKNLDVKDQSAVDAFLNELDGTPNKTKLGANAILGVSLAVAKAGAAEKGVPLYAHVSDLAGTKKPYVLPVPFMNVLNGGSHAGGRLAFQEFMIVPTEAPTFTEAMRQGAEVYQALKGLAKKRYGQSAGNVGDEGGVAPDIQTAEEALELITDAIEQVGYTGKIKIAMDVASSEFYKVEEKKYDLDFKNPESDPTKWITYEELANLYSELCKKYPIVSIEDPFAEDDWEAWSYFSKTQDIQIVGDDLTVTNPLRIKKAIELKSCNALLLKVNQIGTLTESIQAAKDSYADGWGVMVSHRSGETEDVTIADIAVGLRAGEIKTGAPARSERLAKLNQILRIEEELGDQAIYPGANFRKSVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKT2</accession>
    <name>S0DKT2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable Putative DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425081.1">
        <property type="nucleotide sequence ID" value="XM_023573344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKT2"/>
    <dbReference type="STRING" id="1279085.S0DKT2"/>
    <dbReference type="GeneID" id="35393878"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00393"/>
    <dbReference type="HOGENOM" id="CLU_109462_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="121" mass="13883" checksum="F6C71B9B9009C04B" modified="2013-09-18" version="1">MSNSNTPVEDLIRAKITAAFNPQTLEIYNDSHLHSHHKAMEHTTSSETHFRVVITSDAFNSKMQPARHRMVYALLRDEMAQENGIHALQLRTMTPEEEARQRKKKEDEAATRAARAEAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL93</accession>
    <name>S0DL93_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to UPC2-regulatory protein involved in control of sterol uptake</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424193.1">
        <property type="nucleotide sequence ID" value="XM_023579506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL93"/>
    <dbReference type="STRING" id="1279085.S0DL93"/>
    <dbReference type="GeneID" id="35394853"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01368"/>
    <dbReference type="HOGENOM" id="CLU_024934_6_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="491" mass="54172" checksum="286788126BEA075F" modified="2013-09-18" version="1">MPPRRSHKKSRAGCRRCKNRKIKCDEVHPRCGNCAKHGVPCDFSNPDVLEKLAISTNTSTESIGAPTPSPAPTVNFNSAPRTPLPRPRAPSSPARAPRPNPSPPTSVYSQPSISSSNNTIDHGERMLELRLMHHYTNVTSKTLLTNSPAAEDIWQRAVPQMAFSGNGKTYLADAILSVAALHLRSMSPNDKALVRASHAYSASSLSAFGASLGSGITPDNAEALFLTATLIAFQASASRIFVKDDGDSAPGDSTSRYVPPLSWFHAFQGVKTVVANSWQWIHHSDIVKVVIDSQPGFQLNLNPRSPDSFFGHMLEGLNDELMNEDPRLLSSTTQAYSHAVSVLNWAHKNYHAAAALTFPATVSKRYVDLVDARRPRALAILACFFALLKRMDNVWWLQDVARREVMGLVSLFEPRSKWWRHLEWPIRIALLDGSSIPQDIWGTELEEQAPEQQTVGSMTQHIEIFAEMLHQHAQPPIPIADEDLIVPDSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLF1</accession>
    <name>S0DLF1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425332.1">
        <property type="nucleotide sequence ID" value="XM_023573644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLF1"/>
    <dbReference type="STRING" id="1279085.S0DLF1"/>
    <dbReference type="GeneID" id="35393608"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00123"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="10"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="353" mass="37546" checksum="10F6D9445D38AE1D" modified="2013-09-18" version="1">MSSKINKALYVTEDVQFVTRDDLQHEAAATNELLVETSYSGANPADIKHATLLGIRPTVLGYDFAGRVVRAPPASGFKEGDAVAGYTPSGLGRPLKYGTHQGFLAVPCDMVFKIPPNLTEAHAAALPIVVMAAADVVHNLFKLPLPTNPSYSSDPILIWGASSAVGLSILQLARASGCKNIFVTASPARHDILRGLGATHTFDYSSTNVVEEIKSAVSALGKGPITHAVDAVGTEGKPSSADLVAQSVGEQTVLCSVVLRPGTAFQLPLSMIKDGWNIHPTGAPAPITVPPRAADHWNSWSVLQWVITNYGKEFEFPSIHVLDVTAEEALGELMKIQDGKRGFGKVVFKHPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLM3</accession>
    <name>S0DLM3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_02081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423524.1">
        <property type="nucleotide sequence ID" value="XM_023580338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLM3"/>
    <dbReference type="STRING" id="1279085.S0DLM3"/>
    <dbReference type="GeneID" id="35395564"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02081"/>
    <dbReference type="HOGENOM" id="CLU_937021_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF57">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="6">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT61443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="297" mass="34002" checksum="8BFB65E40939C614" modified="2013-09-18" version="1">MASNLYPHRGFMLDTGRKFFPVKAILHLLTLLHQYNFNVFHWHIYDAESFPLLWPGGEGLTNASVKYSQTHTYYTPSDIQNIVSYAENLGIMVYPETDMPGHSDIWGIWKKNLVVGKASLTKPDAQLDIRQNNKAVYDNITSLVSTVDGYFGSPYHHFGGDEVAYMWNTKDDNKLFNTFLNWLKTLTPKKSVILWDDPLTDSEKSITLAKDWIIQTWHKGTTAKILKKGHRVIVSESDTFYIGNADADKISKFVFPKDSKVLGFEIAWFTSQDDSPSDLDQDWILDPLKAASKIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0DME9</accession>
    <name>S0DME9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein ZIP4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_01773</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423824.1">
        <property type="nucleotide sequence ID" value="XM_023574984.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DME9"/>
    <dbReference type="GeneID" id="35395257"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01773"/>
    <dbReference type="HOGENOM" id="CLU_001453_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ERT1/acuK family PAS" evidence="10">
        <location>
            <begin position="460"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="275"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT61743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1465" mass="164035" checksum="9C784E642B5749B2" modified="2013-09-18" version="1">MTDRNAATMGKSAKQEPVKGDDGKAVNRDKSSNATASGNHKAPTKKRRKVNHDVVLRMCSRGFALGFQAVDSSTPIPGAWLNMAHESIYRNKKSIGLTSLRRFIIACVYCRRSERPCTRCIKRNIGHLCHDEPRDADSKKAKSVQSTQSIQAPSVVDESDAQSDMARSSISSTMGPPPPTFDTTRQRGSKSFGGVLGQGSPLSIVQPGQVSGLQGNALNNGNSNANQFAGFQDAWMTAQNHFHDMNSYHPNYMIASEVTHEFNLLNDFLHTSLLDDGSVPPEEQQSPAFKRSSQSQSEMLPMFGNNNTNTSMGVGGSNTMSNMTEGSMLPPPPNVEGKNIPRPGSVVPADKAREYYLQAADPSGNDTPEERMARVLKAKYDAGLLKPFNYINGYSRLGAYLNSHITTASREKILRTIARFRPAFREKAHALTDIELVYVEMWFEKQLMDYDRVFASMAVPACCWRRTGEIFRGNKEMAELIGVSVAQLRDGKIALHEILTEESMVRYWEEFGTIAFDPAHETLLTACSLKNPTPGSTHPVVKCCFSFMIRRDEHKLIGTEFATDLLSKLPTSCDSSSTDVLLSDLNHHIATANVLAENRIAPPLEVSRNLKDIGRKLWNECIKERRKRANLLQSASRTQLLVRTRVLAFLAHALAREHRRGKRRDNLEEIIYMMGLSLTLARVCVESSDLDGALLSMAKAADYIGQLKNINNLTTEDRAQVQKIEAEYLTMRCALSWKQGRLDVAEHMYAKADVLLHNLDPISAEHLADTFHGIGGDLLSKGDNEMALKWLRRALDLINDQALERLSTEGLELRISIYHELIQAFLATGSQDGLQEAENLVSHVESEIGDKPVVLHWRLEILQRSPSEVFNADACASILRRMIRSLDLSDAGLGFLLHGISELRIRGPRLAIGLMDELLLRKLMPSCNMDWIGKAIVRRVWMGTMEADASVSVADLTQTLDQLVQEAGQCDVEASTAALSLIWKKLDTSYSKKQYKESQLWCQLALHSIFANSGEACQGKFSRRLVLCATSCSDAETAFSAFHSMPKSTQDEPLTRYLMFRVSLLNWDHDLGRQCVEFLGKFAEKSQCRDILYACIRDAQHVGDKLMTLEALKAVAETFDDEGSLTINLPSILRCTIRLIHSLESQGGSEGDASPELAEETCRIFERACEHAKLDPRDEQGCKVFTGLWHLIRIFRVCLAFVDCYPSDLPSEDDTDLRLMSVRCHFVIAAALVSQARTEDKVDEQLQQYLETRRHISEFDTLFDTHFRNDPKSQIYPDLLAKLSTLFVFDFESAVCLKSWDDLSQIIRKAQICQNETMYKAMGDCLLRSEASGNVVYGTMRLIINEIFSLEQFDNQQLAKYMRCMFQAILPLDDNLAFQVVEQAVQIAREGSQVQKPFPAEDLDWIIATTFNHAIDILARGDEDLCQQWAMKALDLTKYMDDNGDMRDMLQERVVKLGLSKGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMK5</accession>
    <name>S0DMK5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425747.1">
        <property type="nucleotide sequence ID" value="XM_023571443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMK5"/>
    <dbReference type="STRING" id="1279085.S0DMK5"/>
    <dbReference type="GeneID" id="35398663"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05182"/>
    <dbReference type="HOGENOM" id="CLU_053383_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="352" mass="40811" checksum="C8B731F21ADD7F7C" modified="2013-09-18" version="1">MADKTELDSSLLDLPLQQLTKTTIASEYWVLQHQNQRLNSVDFDLQSFWTYYNKECTRALHNGGRYVALRSHRDVVDCIRKLKRGMLRHDIKEELREKLTALHDNEDEMLDNSIDLAASLLLMISFCSFTYGFSGRSHLRWSHGSLESFVSTYFDPGAPQLAKENAKMEKIFTARNLCRIAGLDIVWTDNLVDHLRLTDDDRRVHVFHHASFLHVQQQSADSLLPKGLADETLQTLALLFPSSDVETRKWFSKLDADIDRRAIQCGQLKTDHRQTEKFRFWNDRLVVLKQVFDEAQPKSLSQWWHDRRNGVQWYTFWVAVLVLVLTIFFGLVQSIEGALQVYASFKGLDGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMR4</accession>
    <name>S0DMR4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425812.1">
        <property type="nucleotide sequence ID" value="XM_023571520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMR4"/>
    <dbReference type="GeneID" id="35398594"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05113"/>
    <dbReference type="HOGENOM" id="CLU_866119_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="321" mass="37053" checksum="1DEC251BF17EA4BF" modified="2013-09-18" version="1">MPITETFFPAFLKACDDDPNDILVIQLTCGTCHEQMTLEDGADPQLRAFALRCMHIYCKGCIDAMVAHSKNDDESHHACPTCRACLHCATCLAPCEKGSLIHRDEGKSIALIEDILKLRRNRWYCFNCDADVFTTWLQMLMKISMDCTDVVNDGQFLRICVEYEGRTWGGPPPDDELWLVNQAPLPMDLEVPIKMIEKGLLKAHGIAVPDDGSTVFNYEIRLYEPRDKQDMFLVWERRHIEKMEQEIRDNWLGSRKLMVLDLAYDLRDLWSDENVRRKMEERVESGKRSMMDYIDDVEEAARDDEEAAGDDEDEEPDVYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMT7</accession>
    <name>S0DMT7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">Plasma membrane ATPase</fullName>
            <ecNumber evidence="4 18">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_01631</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Cell membrane</location>
            <topology evidence="2 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="4 18"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423954.1">
        <property type="nucleotide sequence ID" value="XM_023576562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMT7"/>
    <dbReference type="STRING" id="1279085.S0DMT7"/>
    <dbReference type="GeneID" id="35395116"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01631"/>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000011">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 18" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="815"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="850"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT61873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="910" mass="98227" checksum="8D20AD31529A8719" modified="2013-09-18" version="1">MAEEKAAGAPALDTNIETGGFDEKRGQAAPPTHAPKAPVAEDEEPDEDMDALIEDLESEDGHAFDDEEETQPGGGRVVPEDQLQTDSRVGLTEAEVLNRRRKWGLNQMKEERENMILKFLMFFVGPIQFVMEAAAVLAAGLEDWIDFGVICALLLLNACVGFIQEFQAKTLALKAVVLRDGTLKEVEAPEVVPGDILQVEEGTIIPADGRFVTEGCFVQVDQSAITGESLAVDKHAGDNCYASSAVKRGEAFVIVTATGDNTFVGRAAALVSQSAGGTGHFTEVLNGIGTILLVLVVATLLVVWVSSFYRSNGIVDILRFTLAITIVGVPVGLPAVVTTTMAVGAAYLAKKQAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLAEPFCVAGVEPDDLMLTACLAASRKKKGIDAIDKAFLKALKYYPRAKSVLSKYKVLDFHPFDPVSKKVQAVVESPQGERIICVKGAPLFVLKTVEEDHPIPEEIDAAYKNTVAEFATRGFRSLGVARKRGEGAWEILGIMPCSDPPRHDTARTINEAKRLGLSIKMLTGDAVGIARETSRQLGLGTNVYNAERLGLGGGGDMPGSEVYDFVEAADGFAEVFPQHKYNVVEILQQRGYLVAMTGDGVNDAPSLKKADTGIAVEGASDAARSASDIVFLAPGLGAIIDALKTCNMYAYVVYRIALSLHMEIFLGLWIAILNKSLNIELVVFIAIFADIATLAIAYDNAPFSQTPVKWNLPKLWGMSVLLGVVLAVGTWIALTTMYANSEDGGIVQNFGKIDEVLFLEISLTENWLIFITRANGPFWSSIPSWQLSGAILIVDILATLFCIFGWFVGGQTSIVAVVRIWIFSFGVFCVMGGLYYFMQGSTGFDNLMHGKSPKQNQKQRSLEDFVVSLQRVSTQHEKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMU4</accession>
    <name>S0DMU4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424773.1">
        <property type="nucleotide sequence ID" value="XM_023571818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMU4"/>
    <dbReference type="STRING" id="1279085.S0DMU4"/>
    <dbReference type="GeneID" id="35394214"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00729"/>
    <dbReference type="HOGENOM" id="CLU_028484_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000002">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="508" mass="59098" checksum="DE99F8BE334DBD8F" modified="2013-09-18" version="1">MDSPIVAQIFRQLFHHRPPGCKGVRNLAGLRNGLRTTTIVSHQSRFYVAGRPSSDRGMKKNESRWQQRTNILPQDRSTEFAEYPYISIDELKQRTERPRKVKMLLRDFIDGMTLDLYNPSYGYFSKQAVIFSPGEPFDFNSMRDEIEFQAELGRRYTEFEDILDEREGENPTRQLWHTPTELFRPYYGEAIARYLVTNYRLTTYPYHDLLIYEMGAGRGTLMLNILDYIREVDPQVYARTKFNIIEISSTLAALQNRHLLSTAASRGHADKVEIINRSIFDWDQYVPSPCFFLAMEVFDNFSHDGIRYDVATEQPLQGHVLIDGDGDFYEFYSQELDPLAARYFRVRHAATGGNYPKPYPSNVVLRYLSTKIPFAANLSDPEFIPTRLMQFFDVLEKYFPGHRLVTSDFDWLPQAVKGMNAPVVQTRYHRKMVPVTTPLVHQGYFDILFPTDFRVTEAIYRAITGKLTRVMSHGDFMRKWAYVEDTETRSGENPLISNYRNASVLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNI0</accession>
    <name>S0DNI0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to putative arabinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426215.1">
        <property type="nucleotide sequence ID" value="XM_023572006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNI0"/>
    <dbReference type="STRING" id="1279085.S0DNI0"/>
    <dbReference type="GeneID" id="35398160"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04679"/>
    <dbReference type="HOGENOM" id="CLU_010779_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF8">
        <property type="entry name" value="ARABINOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484762" evidence="1">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="335" mass="37195" checksum="0AD196EF9497AC73" modified="2013-09-18" version="1">MRVITLLATALSASSFVKAIPADSPRSANSKYVGYLISTFSDPTPQVQWHLSDGNSASTFHFLNGGKPVLTSNVGTRGVRDIFLTTNTARSEFFTIATDLDINAPGFSWDLVTRNGSRGLVVWSSKDLVNWSKPSLRIVESDTAGMAWAPSAVWDDSTNQYYVFWAARHYSASDTEHKGTATLDRIRYATTKDFKTFSAPKDYHAPDDTGLIDQEFLYLGKPGHFARFLKNETINKVYQETSTTGLFGTWTRVPGYVRPESPLEGPGAFADLRTPGLYHLLLDDYTQYIPFQASNILSPNWEKSDFPNFPKGLKHGSVTPLTKKEYDAVATKFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNN6</accession>
    <name>S0DNN6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426285.1">
        <property type="nucleotide sequence ID" value="XM_023572098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNN6"/>
    <dbReference type="GeneID" id="35398079"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04598"/>
    <dbReference type="HOGENOM" id="CLU_589297_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484342" evidence="2">
        <location>
            <begin position="19"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="400" mass="43024" checksum="3B100F09A25B2570" modified="2013-09-18" version="1">MVRFTPLAALALVPLAQARFDWLYSRDTIAQCPPCSLESEPKDCSHTVTVTKPSGPYETVTVSDPNGSYRTVTVTEQDGPGKTVTITQNYQNPQTKVVYISQGETVEPAIETITVTRPGKTVTVTATETETSEHIITKKIDSYPGPKTVTISNGYGHEEVVTVTGKDQYEVTKTVTMENGNKVVETITAENTNNYVVTKTIQQGGKYYTVIVKPEPAVSTITKENGDCITTVVEVDQTYTLTAPAKYGTATVADDDCDTYTRTATYTGKPEVEVIVYDPETGDSTCTKEDGKPCNPGYDNGGDGSKGQYEDPTNTKGRDGSGNYNSNAPVYTKIRTYGNGDVYTEVHGAEPTGCESAAVSTSIATVYNTVVVTADASPSKAPTAERRAANKVRSPLSVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ19</accession>
    <name>S0DQ19_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to putative C2H2 zinc finger protein flbC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_04251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426602.1">
        <property type="nucleotide sequence ID" value="XM_023572486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ19"/>
    <dbReference type="STRING" id="1279085.S0DQ19"/>
    <dbReference type="GeneID" id="35397732"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04251"/>
    <dbReference type="HOGENOM" id="CLU_053582_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT64521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="301" mass="32870" checksum="9554E6ABBC964791" modified="2013-09-18" version="1">MPNQYNQQETPFFTRRDQYQPPSPPMEEQKCSLPSISNLLGLADAGSPTSESSPTSRQHSPRFEVPPPSHGHSRAGSEWAKSSHRGLPPTPPMSTDASFEGYSSPTRKSSNQAYAGSAPRPYYYETTPPLEADAQRQASVPAIPRATPPATAPYPQQAHPTVYANPAPVGAYYQTAPVPSAAQSQEMNPYYQRPLPQAYPPPVSMPAPAPSGANPWQHHHYLNPTGAAAFPQSQDRYICPTCNKAFSRPSSLRIHSHSHTGEKPFKCPHAGCGKAFSVRSNMKRHERGCHSFEFNGSVIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ63</accession>
    <name>S0DQ63_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein PTH11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426805.1">
        <property type="nucleotide sequence ID" value="XM_023572734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ63"/>
    <dbReference type="STRING" id="1279085.S0DQ63"/>
    <dbReference type="GeneID" id="35397509"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04028"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="378" mass="41604" checksum="13D1D0E3826C3834" modified="2013-09-18" version="1">MAAATPSPEYLAETRGPMIRTVTWLSVIFPILFVGLRVYTRLFVRKVFGLDDWVIVLSLILLICYGAIIEAAVQKGLGRHIEWVLTFAPQDAVPVALLGQVSQPFVVMSCALGKTSFSISLMRLAAQRFIHRFLWFIVVTMLTLHILISIIVFVHCEDPRTTWNPAIVSKCWHPNAYLGVLYFIGAYSAATDFILALLPWAMLWNLNMKNKEKFGVAVAMSLGVFAGAIAVIKCTKLKANATSTDPTYDVGELLLTACAENALIIMAACIPTLRPMLRKVFPSSAKSSENSHRLKNMNNIMFVPKNKAGQWSALIETEAHPDHNSDNQSDKSILKEHRGTMNGQSNAGPAGGPASPALSPHIRKTMSVNVSYDRSNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ88</accession>
    <name>S0DQ88_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425633.1">
        <property type="nucleotide sequence ID" value="XM_023571303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ88"/>
    <dbReference type="STRING" id="1279085.S0DQ88"/>
    <dbReference type="GeneID" id="35398788"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05307"/>
    <dbReference type="HOGENOM" id="CLU_1147262_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27398" checksum="88A64C83CCDD3226" modified="2013-09-18" version="1">MDGLSAAASIIAVVQLTAEVTKYIIGVAGASKDRQRLLDEIFACEAILMRLRDYSKETDGLDIEDWNADQTKADSAQMCGIQKVKAALKWPFNEKEVIKLVDAFQRERSLLHFAMTHESTQLVKHIKATSDDNRRQLADLVRLIKSKATEDEQRVARLGRILTDLQLSSLHIAEGIGHLQHSQISVHQKEVLDWISPVDYAPQQSEIFSRREPGTGEWLLESDEYNSWVKGDSRSDRSLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQZ9</accession>
    <name>S0DQZ9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histidinol dehydrogenase</fullName>
            <shortName evidence="6">HDH</shortName>
            <ecNumber evidence="6">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_03752</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 11">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427060.1">
        <property type="nucleotide sequence ID" value="XM_023573041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQZ9"/>
    <dbReference type="STRING" id="1279085.S0DQZ9"/>
    <dbReference type="GeneID" id="35397233"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03752"/>
    <dbReference type="HOGENOM" id="CLU_006732_3_3_1"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000026">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF14">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT64979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="438" mass="47107" checksum="A736BA6447F15966" modified="2013-09-18" version="1">MARTHLKRPASAKSTSKATNGSLPDVPRIVKDVIDSVRREGDAAVQRYSEQFDKWSPSSFKLSKEDIDQVIARVPEQVIKDIKAVQSNVRKFAEAQLNSIKEFEIEMAPGVFLGQKNNPIDSVGAYIPGGRYPLLASAHMTILTAKVAGVRNVVACTPPAAGEIPLATVAAMHLAGADEIFILGGIQAVAAMAIGTETVPKVDFIAGPGNAFVAEAKRQLFGQIGIDLFAGPTEVLIVADETADPYMIATDLLSQAEHGPDTPAVLICTSAEVAESAIKYCDDQLASLKTAAVASVSWRDYGEVILADTVDEAYQIADEFASEHVQILTANPREALIKMQHYGALFLGPMTCVSFGDKCIGTNHVLPTKHAARYTGGLWVGKFLRTVTYQEVKSAQASGELGQLCGRAARVELFEGHARSGDIRAHRYIGDKFEWIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR21</accession>
    <name>S0DR21_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426981.1">
        <property type="nucleotide sequence ID" value="XM_023572945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR21"/>
    <dbReference type="STRING" id="1279085.S0DR21"/>
    <dbReference type="GeneID" id="35397319"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03838"/>
    <dbReference type="HOGENOM" id="CLU_061887_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="268" mass="31143" checksum="E21D88A22544FB7B" modified="2013-09-18" version="1">MSSMRNAVARRPHRERAQPLERRRLGLLEKHKDYSLRAKDFNKKKAQLKNLKEKAAERNEDEFYFGMMSRKGPGSRIQDGKRWSGTVEGDRGNKAMDVETVRLLKTQDIGYIRTMRQVVAKEVARLEEQVVLTRGFDKLDEDEDDADEGSDSEFDFATAPSRPKAPRKIVFMDDEEQREETILDLEDEEDADKTFEGFDDDKKKEEDFERAKALRRLRRQLENARKKLKALTDAEGELEIQRAKMAKTATSGGTTRKGKKIMVRTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRD7</accession>
    <name>S0DRD7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.12</ecNumber>
            <ecNumber evidence="10">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_03844</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="13"/>
    <dbReference type="EC" id="1.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427205.1">
        <property type="nucleotide sequence ID" value="XM_023572938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRD7"/>
    <dbReference type="STRING" id="1279085.S0DRD7"/>
    <dbReference type="GeneID" id="35397325"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03844"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="17">
        <location>
            <begin position="10"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT65124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="353" mass="37455" checksum="B8BFB2D9B976E840" modified="2013-09-18" version="1">MASNLSFVLNKPNDVSFEERPKPTLSSPHDVLVAVNYTGICGSDVHYWVHGSIGKFVVEDPMVLGHESAGTIVEVGSKVKTLKVGDRVALEPGYPCRRCQNCLAGKYNLCPDMVFAATPPYHGTLTGYWTAPADFCFKLPDNVSQQEGALIEPLAVAVHIVKQARVKPGDSVVVMGAGPVGLLCAAVAKAYGASKIVSVDIVQSKLDFAKDFASTHVYASQRIAPEENAKNICELADLPEGADVVIDASGAEPSIQASIHVLKNGGSYVQGGMGKADITFPIMAFCIKEATASGSFRYGAGDYPLAVELVATGKVDVKKLITGVVEFKQAEEAFKKVKEGEAIKVLIKGPNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRF4</accession>
    <name>S0DRF4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable NADH2 dehydrogenase (Ubiquinone) 9.5K protein, ubiquinone-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425209.1">
        <property type="nucleotide sequence ID" value="XM_023573499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRF4"/>
    <dbReference type="STRING" id="1279085.S0DRF4"/>
    <dbReference type="GeneID" id="35393738"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00253"/>
    <dbReference type="HOGENOM" id="CLU_166990_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="76" mass="8436" checksum="59D17EC6219C6ED2" modified="2013-09-18" version="1">MSAAPLFWQTPLKYCRWAARERPALFWSVIIGAAGPVAMPIVPPIRHYFGDIDAPPVPVTYPIPSGPRKQLTGYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRL1</accession>
    <name>S0DRL1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable NADPH2 dehydrogenase chain OYE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_04688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427162.1">
        <property type="nucleotide sequence ID" value="XM_023571997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRL1"/>
    <dbReference type="STRING" id="1279085.S0DRL1"/>
    <dbReference type="GeneID" id="35398169"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04688"/>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="375" mass="41102" checksum="584AC712B667E250" modified="2013-09-18" version="1">MRLKETKKLFTAVKVGKVELQHRVVLAPLTRRRADETTAVPAPYAAEYYAQRASSGGLLISEGTFIAHEAGGMSRVPGIYSQEQIAAWKTITAAVHAKGGFIFCQLWALGRVANPKIVPHVWSAGSVPFDAKGTGSAEPPAKFTVMTESDIDRFVGHYRQAALNAIKAGFDGVEIHGANGYLIDQFLQTNSNNRTDSYGGTLENRFRFPLKVLNAVCEAIGSDRVAIRMSPFSRFQGMRETEPLAVFAPWAEAIIKAQPSLAFIHAVEPRIAGGSDSPDKILEENENLAPIRKIVGSSEIKFIVAGGYTPETAVMHAAQTDDLVAFGRFFIPNPDLPARIQNGWPLTKYDRSLFYTPDEHGYTDYPAYKPEASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRS2</accession>
    <name>S0DRS2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427221.1">
        <property type="nucleotide sequence ID" value="XM_023573050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRS2"/>
    <dbReference type="GeneID" id="35397224"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03743"/>
    <dbReference type="HOGENOM" id="CLU_061413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT65140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="232" mass="26392" checksum="353FC02EB10B715F" modified="2013-09-18" version="1">MIANYVEEAIKELERNPKYHDEINKLASAHVLTMDVDEEETFDACGAKFTRDGKLAIVFGADRLGSNTGDAFWHKNLEKGISLAPTTDTLSFYARKSIREDYEPDIADVQSELKDILHKDITLHPHFEEVYEKLKQTKDGTDFDQYLGAFILNYFRGLVSTLKWRKFDSDDMLQEALNEAMEKGEVHFRILDTVEGSSGEAAIEDGILYLQTSPDKWGSNIDDISNNIMDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DST5</accession>
    <name>S0DST5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425714.1">
        <property type="nucleotide sequence ID" value="XM_023571403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DST5"/>
    <dbReference type="STRING" id="1279085.S0DST5"/>
    <dbReference type="GeneID" id="35398698"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05217"/>
    <dbReference type="HOGENOM" id="CLU_067153_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="355" mass="39626" checksum="CF4F920A51F0140D" modified="2013-09-18" version="1">MHAKRNIPGRVALSSVSLLLLSLLLLHYSFIPSFPLSSWNSPVVGLDDDFHNSLPLDPLIKREDAKVDVFKKAFDKGKGLLCDMGKSQEELEEEYGKSMESPSYLQKSGIEENEGWEIESDPQPSFKDYLNEALTALGVSDDLHHQSWMHTSGGIISTTNPGDLASGTSGEDTGAYFRNSFAVNPGVIIADVNYAVSATGNDDGKKLVTHVKKWSDATWMQWDRVCTEADGDVKDLKYFIRSKIANYATLEIILRAILSRHERNPRRNKNTIGTWKNKITFTSAKDKEEFPAILGSPNGAGAAFMLINHKKRLGVKTIKRIDVFVPEGSFEVTETEVGENHEQWNVMMLMYIVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSY0</accession>
    <name>S0DSY0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to negative-acting regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425779.1">
        <property type="nucleotide sequence ID" value="XM_023571481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSY0"/>
    <dbReference type="STRING" id="1279085.S0DSY0"/>
    <dbReference type="GeneID" id="35398629"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05148"/>
    <dbReference type="HOGENOM" id="CLU_008871_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF27">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="5">
        <location>
            <begin position="570"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="4">
        <location>
            <begin position="712"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="6">
        <location>
            <begin position="854"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="911" mass="100539" checksum="AD8C16A717EBDAE3" modified="2013-09-18" version="1">MAGVKRSLGTFLGHEDTLLRPNGHSRPKTVHYNHGIPRDNLDNSTPQSQSFKLSDVLQSQPPSRATSRANSRANSQSAAPSNTDQHDGLTRTPSPTFPPLTGQVPDFSPDASMILVGMRGAGKSTLAIMASSAMDRKVIDLEPAFQRSMGLSSAAYKSEHGSSECYKQQAKILQSILQRHSTGCILVCSWMESRVQSLLREFAATNPVIHIVRDFDAIKNHLKIRDGSKVQSLLDVSNAIFRSCTNFEFFNVTEKASKSSLSRESLTQRSPAPYLTLKHVERHFLKFLSLVYPAGTIPFTDSAFPLSRIPAEERNFTYATSIPLSDVIKDSVDVEDHVIGADVVQIVVHDLAEHAEQGTLTSEASGKLLANITKGVGIVRRSTILPIILHLFLPYTASDEVLRVYLDLVHHSVRLAPEMMTVDLRLEDVHISRILSIRKRTKMIGNCFITTDPPSWESPIWMSWYKKANNLGCHLARLIRPAVTIEDNFRIHHLKTSVAALQGPKIPLISYNSGPLGRNSQAFNRVLTVVRPDSLERVNPRPPITPSITTVGATEALFSSFIYDQMKLYVFGANVSYSLSPAMHKSALKACGLPHTYEPVSCASLRGIKHLIEDPEFGGGSIGLPFKVEIITLTHSLSKHARAIGAVNTLIPIRFLNEDGTIPTGAAFFDSVNRSGPIKALYGENTDWIGIRACIRRGLSPANAVVSSTCGLVIGAGGMARATLYAMLQVGIKNIVICNRTPKNAEKMVSHFTQVLERKDHGLLSAGSEHSRFHVIESIEDAWPTEFRLPTVIVSCIPTHRIGNVPAPDLTLPNEWLGSRTGGVAIELGYKTLDTPFLAQFRAESHRGWVSMDGLDMLPEQGFAQFELFTGRRAPRRLMRRMVFEAYPNEEGKSNFEELQPRLQSLDEQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTE7</accession>
    <name>S0DTE7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425934.1">
        <property type="nucleotide sequence ID" value="XM_023571667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTE7"/>
    <dbReference type="STRING" id="1279085.S0DTE7"/>
    <dbReference type="GeneID" id="35398463"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04982"/>
    <dbReference type="HOGENOM" id="CLU_021695_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="464" mass="51451" checksum="AB1804E7BD79BEFD" modified="2013-09-18" version="1">MDEIAPEYDVIVLGTGLTECILSGVLSVKGKKVLHIDRNDHYGGEAASVNLETLFKKYGNFREGEEPWKQYGRLNDWNIDLVPKFLMSSGELTNILVSTDVTRYLEFKQVAGSYVQQGASNKATVAKVPSDAAEALRSPLMGIFEKRRMKSFIEWVGTFDLKDPATHKGLDINKCTMKDVYDKFGLEATTKDFIGHAMALYLTDDYITTPGQAPEAIQRIRLYGNSVARYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLNTNIDEIQYDGDKAVGIEATMTGVEEMKFKTKAKMILGDPSYFPNKAKVVGHVLRAICILKHPLAGTNDADSAQLIIPQSQVGRKNDIYIACVSSAHNVCPKGYWIAIVSTIAETSANHHVELQAGLDRLGKIEEQFMGPPIPIYEPLEDGTKDNIFISKSYDATSHFETTTDDVKDIYHRATGEELKVEGLREGIQVAEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTT8</accession>
    <name>S0DTT8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_02835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427936.1">
        <property type="nucleotide sequence ID" value="XM_023574613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTT8"/>
    <dbReference type="STRING" id="1279085.S0DTT8"/>
    <dbReference type="GeneID" id="35396317"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02835"/>
    <dbReference type="HOGENOM" id="CLU_009834_22_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="70"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT65855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="504" mass="56143" checksum="073D9F217D5CABDE" modified="2013-09-18" version="1">MSFRTLTVRACASANVANRSSPRIFNMVQQSKILSSSLGARQLSSEATNIREKRGDSSNDVVFESKYGLRTVMLNRPKKLNSLDASMIRKIVPRLIEWEKSDLANVVVMKGAGEKALCAGGDVTALAHLNSESEDGWQKSAQYFALEYKLDHYIATYKKPYIAFMDGITMGGGVGLSAHAPFRIATEKTVFAMPETTIGFFPDVGASFFLPRMNGSVGTFLALTSERLTGPNVFYSGIATHYLHSTSLPDLEARLAELRFRDSDGLPERLALINRTLEEFCTGLPYDQPITLSGEIRKAIDRCFNKHTISEIIAALQAERGPTEEWAQKQLKTLHKRSPTAVHVALRQMRVGGEWDIAQTFKREHQIATKFMQHPDFTEGVSALLIRKEAPKWQPESLEAIGGTNVAKPFFEYDSNNELALFTDRTFKEYPHRELGVPSEKEVEQTLSRGTYTQEQLANKIVSSRNGRQGIAEVAREIIARKTAVDDQGKAVWMADESLPGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUE8</accession>
    <name>S0DUE8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04626</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426259.1">
        <property type="nucleotide sequence ID" value="XM_023572066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUE8"/>
    <dbReference type="STRING" id="1279085.S0DUE8"/>
    <dbReference type="GeneID" id="35398107"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04626"/>
    <dbReference type="HOGENOM" id="CLU_022829_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF37">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="293"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT64178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="627" mass="72070" checksum="756A04F6B9476397" modified="2013-09-18" version="1">MGALCSRTEPVEGAQDDYDQHHRKDHSHTDFMTRLSKRAKISRMGEPALDDAAAARNHIQAHDAEILARGVLIEKAEITDAVTQEPGVVGEYFKLRQQMVAREKALDFDHGCRMRSTPSERRAEAILQRLRSEDEENVYAQAAPRTGYGGQQHPRFPGDHFLSNKHLIDSTSLFRVAQHMPKGGHLHIHFNACLAPQVLLNLAKEMDRMFITSDIPLVSDNDFINFDRCEIQFSLLSPEKETPGDLFSEAYQPRQTMRFRDFLDRFPGYYAKDSTNVDEWLFEKLMFHEGEAHNHLQTASGAWEKFNGRTRMMKGLFNYATAYRRYTRLCLEDFMKDNISYAEIRPNFMTSNQLWSDDGTQLIDNKGIMELIIEEVKNFQTDMKKQGKFFGGLKVIYCTPRSFAPAQIDAALKECLKFKQIWPEWIAGFDLVGEESKGRPIKDFIPELLKFQEDCDRDGVEIPFLFHCGETLDMGTDTDGNLVDALLLKSKRIGHGFALAKHPYVMQHMKERGVCLELCPISNEILGLTPRVSGHTMYQLLANNVHCTVSSDNGTLFRSSLSHDFYQVLVGKADMGLFGWKQLALWSLEHACLSKSEYNRVFSDWEQKWKEFVKWMIEEYDEQPKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVA6</accession>
    <name>S0DVA6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to general amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_02267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427413.1">
        <property type="nucleotide sequence ID" value="XM_023573977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVA6"/>
    <dbReference type="STRING" id="1279085.S0DVA6"/>
    <dbReference type="GeneID" id="35395749"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02267"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF3">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="89"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="438"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="242"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="561" mass="61275" checksum="8BEB087637A6E761" modified="2013-09-18" version="1">MPATTTNWKTIAAEHREKQRDAVPTEWLLSEKQLQGLKNTGDGGGSKLIESKAVQRSGLLTEKEIAITERHTAAELLSKIHSQELSSEEVTVAFSKRASLAQQLTSCLTEIMFKEGIQRAKELDHQLKTTGKLTGPLHGLPISLKDSYRVKGHHATVGYVEFLRQPMPDHNSALVDLLLDAGAVLYCKTNLPQTMMTADSENNIFGRTLNPHNTSLTAGGSTGGEGALVAFRGSPLGVGSDIAGSIRIPSLCCGIYGFKPTSERVPFGGQSEYPFPKDHLPGIAPVGGPMANSIEDLELFMKITLAQRPWNYDPTVADIPWRDLGEADTKLTIGVMAEDPDYPLHPPVRRALAKAASALENAGHKLVYLSQDPKRNAGLGGRIGFQLFSIMGPDLDTVSREIGEPLVNSVAIAVHPFTNGNFPVPPDLDTPTKLSRLNEVRFEYLKAWQETYRDNKLDVILAPGAATTAIPHDTYGVPIYTLMWNVLDFPAGIIPFGNSSKFEDSEHVKAKAPFDPDYIPEATDGAPTAIQIIAPRYRDEECLRAMRIVDKTIRNSRAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVH2</accession>
    <name>S0DVH2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_03515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428562.1">
        <property type="nucleotide sequence ID" value="XM_023575371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVH2"/>
    <dbReference type="STRING" id="1279085.S0DVH2"/>
    <dbReference type="GeneID" id="35396997"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03515"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT66481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="317" mass="34008" checksum="FDCDF4E8971579E6" modified="2013-09-18" version="1">MSSKLYDVLIIGGGPGGLAMASALARQVYTALILDSGVYRNAPTKHMHNVLGFDHVEPSVFRNKAREDLEKRYESIEFKSTTIATVRKTDAGVFEAVDQDGNVYQGKKLGLGTGVKDLVEEQPKGYAECWGKGIFHCLYCHGFEERGADSVGVFAGGMVSSADMLAHVTPMAKRLSQSVTIYTNGDTSLPSTIKTKVHSSKVHYDARKIASFALINGGPAVKITFDDGSSKTEGFVVSHPNVAQAAPFAEQMGLEKTVTGEIEVSVPMNETSVKGCFAFGDAATVMRSALQAMHMGGFAAVGMAMQLQHELDEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVW1</accession>
    <name>S0DVW1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to ATP adenylyltransferase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428717.1">
        <property type="nucleotide sequence ID" value="XM_023575552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVW1"/>
    <dbReference type="STRING" id="1279085.S0DVW1"/>
    <dbReference type="GeneID" id="35397159"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03678"/>
    <dbReference type="HOGENOM" id="CLU_049915_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="98"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="194"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="312" mass="34057" checksum="2EFDA08BD0C8A5D4" modified="2013-09-18" version="1">MTYDRPAPTTDGSALLSTFDALTKSGLVLYDESQKVVEHTDGGLKVRSFHFVLTKALIKKPTLSTPDQSSASGSGLSKQLTPGSDIDTNGFEMGHSESSTHFLIANKFCFSRPHLMMLTRDGYCRQYEPLNKTDFEAAWGTLASLNDATKDYVVFFNCGKDGGCSRLHKHVQLMPLPASGFAVDFLNSDSTKEPKVPFEWFYQRFQDSAVSASQVAETYLKLLQQATETWKASTGKDVLDGQACPHNVAFTSRWIVIIPRRKAAVNKEAGVNSLGMLGIIAVATEKEIENWVKLGLTNSLSELGVSSGVGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWJ0</accession>
    <name>S0DWJ0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to WW domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427843.1">
        <property type="nucleotide sequence ID" value="XM_023574500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWJ0"/>
    <dbReference type="STRING" id="1279085.S0DWJ0"/>
    <dbReference type="GeneID" id="35396215"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02733"/>
    <dbReference type="HOGENOM" id="CLU_003963_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000028">
        <property type="entry name" value="WW domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1182" mass="127947" checksum="6FB05BD326FE4B9F" modified="2013-09-18" version="1">MERSRGVPDEEMFLSKPAPEDCDSPTVEPLRIFKPQSPQPTKDGRSSAFRYPAPPSSTSPVSKHSFPLPPGASSSAAPLPFPDDDDVRKPTPAKPFGSAYNDTSPRLETSPPGKKPGLAERRGAAPKPISSPTSPDADTDLFQRPLADSHRPGSSNNNYPSYQKTYYPPPGAASGSSSNAPAKPAAVQQLKMNDQGVNRFASTASTSTTRASRGSPPPPETPIVEPGQAPADAIEARYAAAGISGTATLNSLGAPSAAASQRLAQYGNQPPPQRPWTPTETPDQAPSGPPTVYQGMNAISSPAQSHQSFSPPPQPEQQQQQKPQPQGQGQGQAQVSVLEQDFQRMNTNSPPPAYSSLNPGGNSSYPNEKQRPQQAGSSSAAAQPNQQVTASTAPTKAAAVAAASTIAGGLASPALQHPGHPAFANDPHPAFANEPHPEQNGQPSQQQVVAPAQTFEPQNPASPPPLPEGWIAHLDQNSGQYYYIHLASQATQWEFPKGPNPISHEQAPLSPTASTYGNPLASPMFGKQAMASPMFPPHTPGYAESIMSVAASATPTAAGFTGPPPSAGVDMYRIQPTNGVYFGPYLRYVNMDIEKGLWLGSILIVTDAPQPPTIHIHLSHDLAPNPRQAEPRPIFTHQRWKFYKYDLELPMSEAGTERWTYAVTSHLGCTRYEFVVAGRQETSWRFIAHSGNDFAAGTSQNERAKLGGVGFMWKDVLQKNVDCGGFHVQLGLGDQIYGDRLWKEVPLLKQWLAMSGRDNKKNVQWTARHEEDVAHAYFHYYTSHFDQPFLREAFAQIPHVLQIDDHDIFDGYGSYPDYMQSSPMFKNIGRIATEMYLLFQHHTTVEMLRNVSTDHDIFTITGTGWHFVKYLGPAVVVVGPDCRSERTQAQVMAGPTYQGIFPKVATLPPSVQHCIWMISVPLVYPRLDTVESLANTMAAGKKAVNTTYNILGKVTSSVAGVVGGKDVVAQGFSQVKKAVGKTGLMGNVLNQFGELDIQEVLKDMWTHDTKDLERTYLIRTLQDVNASGAGLVHDPTHPGDHKTMYQIISSPIVAAPQSNYVLKMLHNQKTLYVPQNGKKSTHEVSDTKEDMMEIFHSDASGAARELKKLMGRRNYVAFVSYDQDAAAAVPQTPFSPNPSLNGSQQGLSKVSLAVDFVVQGDGAFTAPTKYGPVIIPHLEYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWP5</accession>
    <name>S0DWP5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to Pst1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_02799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427903.1">
        <property type="nucleotide sequence ID" value="XM_023574574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWP5"/>
    <dbReference type="STRING" id="1279085.S0DWP5"/>
    <dbReference type="GeneID" id="35396281"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02799"/>
    <dbReference type="HOGENOM" id="CLU_005863_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="3">
        <location>
            <begin position="237"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="4">
        <location>
            <begin position="387"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="2">
        <location>
            <begin position="905"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT65822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1233" mass="130822" checksum="1114B22825596145" modified="2013-09-18" version="1">MRLPFQRRSPSARQSHSLGPVLGPSLAVLAALAPSLTHAITFSPVPSPNLDFSNLGRIGIVGDYDGISLYEYEGQKESTRSSNGSESLLAQMPNGAFVSILSTDASIRAMCSFQLSNGDMQGVVIGGNFTSLDGTQSKAVALFNPNTTEITPLDGIEGEVNALYCDQERDTVYVGGNFKGANSTNAIAWVGTDGWTNLPFAGFNGPVKAITKASNGHIIFGGTFTGLGNSSTPNSSSNQVINLSTANITDENGSSGTDPTDIVCPGSSSTPWLLQDDTPGYWEADFSFGFAPTKLRLRNTRQDGRGTKTFRFLAYPINGIMNLTYVDSESGNNITCTSECPLRDDEDYQDFTFVNRVGMNKFRIAISDWYGSGGGLESIELFQSDIFAYAITDFNEPKCGGVKNPASATHTGPWKVSPSLESSSEYLTAELNGDYDPEKISVTFFPNIIESGNYSVNIYTPGCQADDTCATRGRVNITGVMSGDDDKDTNFTSTLYQTNDFDKYDQIYFGYIEKSSGSFTPSVTLRPLAGQDVDTLTIVAQRVEFTLTNSTGGLNGLFDFDPEQAVVNATSIVNSPINKLGASFDRASGVSVLVTDSNTTYVGGNFTSKDHDNILAIIENDDVKEPGGGLNGEVFAMYLNATQLYVGGDFSNTDSGPVTGLDNVAVYDTKEDKWGALGAGLNGPVMRAVPLMLNITADTPELVIAFTGEFSSCNSFANHDAIFVDGFAIWVASQGNWLQNIDGNYPAFDGSLTAAVLDIPMDGGSLYAGALSSAQLGTNGAATLSDDGLGQFPLKIRAATPSSSSSALSRRDVTSFNKNTTGVVTGIFYDENDYNITILAGHFTTESTEGDKLQNIVLLEDDNVAGLGSDISNGSTFVALAVRNGILFAGGDISGTIDGTDIRGLVSYDLEAKSFNSQPASVSGANSTVAAIAVRPGDSGDVYVGGSFDTAGALDCPGLCTYNVNSGQWNRPGSELEGTVYSLLWLSNNQLVVGGDLRGNGSDQRFLASWDANSESWSNFPGSEDIPGPVAVISPGSIDYDQLWVAGTSLKDDSVYIMKYDGEKWHAAGPSLSSSTIIRGLQVFSVTEDHETADLLDKNQVLMLTGSIDITGFGAASAALFNGTTYQPYAMTIKAGDGPGTIAGIFTQRDSFFKEEKHMALGFVVLIGLAIALGLMLLLVLCGIILDRIRKKREGYVPAPTSMYDRGSGMRHIPPHELLESLGHGRGGAPPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWX4</accession>
    <name>S0DWX4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427074.1">
        <property type="nucleotide sequence ID" value="XM_023573057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWX4"/>
    <dbReference type="GeneID" id="35397218"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03737"/>
    <dbReference type="HOGENOM" id="CLU_1115788_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT64993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="249" mass="27843" checksum="E42F4D73AE9ABFB3" modified="2013-09-18" version="1">MSQTSLVGSSSSGEAPRNALSLRLETPLFSQAPISPSKQSFSIQGRYVYETETSPATPTYHISNRNTQAGNPWQIQICRLLPSEVRRLSEASGNDAFIRYDDDLTLYSGEKMNIPFSFAAGLGPTPLIVIRGQKRGTIQGSIVMEKSGRSCKFQHMIPIKRALTKVEEDKMQALMHKRGYRDSDDWKKKLLLTVQENSAKLVEWADEYGTIVAVEKDDKLEFSGEILTEKKDLVVACWACKGFVLEQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWZ7</accession>
    <name>S0DWZ7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429150.1">
        <property type="nucleotide sequence ID" value="XM_023575915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWZ7"/>
    <dbReference type="STRING" id="1279085.S0DWZ7"/>
    <dbReference type="GeneID" id="35406705"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13251"/>
    <dbReference type="HOGENOM" id="CLU_033002_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47599" checksum="11A4872A26D176A5" modified="2013-09-18" version="1">MAPSEDEIEQALLDATYQVYQATPDETTVNKVRKQTEENLSLDDGFFSSAEWKQKSKSLIKDRVEKLMDGWVPDSNKNADSDREDKAGVKRSSPDAESPEPKPKRQKRVTKPRPKPKSKKAKKKEESDIETDLESKPSVSSELSELSDLSEEEKPQKKRKRAAPKHKSKAVELEEEDEEDAIKSESEVSGDDDDEVENGELASEKATSSTIPQNSEDGEEGSKGDENKPVVDEEDEYSDVIDEPVKPKRKRKEKKEAGSKPAKATKVATKKAATSDDPNTEEIKRLQGQLTKCGVRKLWHNELKKYGDDAKAKIRHLRKMLTDIGMDGRFSEAKAREIKERRELLAEVESAQEMSALWGVEGRGRASRSKSKSAKVVESGGSDAEENDGDEHNDDEEDEEETYAARRKRARADLAFLGDDDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX17</accession>
    <name>S0DX17_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_13209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429112.1">
        <property type="nucleotide sequence ID" value="XM_023575866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX17"/>
    <dbReference type="GeneID" id="35406663"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13209"/>
    <dbReference type="HOGENOM" id="CLU_2210268_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="107" mass="12401" checksum="F23E730B9077D877" modified="2013-09-18" version="1">MLRFADSLMWFDCKNVLQNRKGFNLRELDLPPYEGDLYHNLHSVCIVVPALYMRQVGQGDTLKSASVIRKQQISEAWGSEEQRRVYQDNGRRTLISHLFALKSSEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX79</accession>
    <name>S0DX79_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_13313</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429207.1">
        <property type="nucleotide sequence ID" value="XM_023575985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX79"/>
    <dbReference type="STRING" id="1279085.S0DX79"/>
    <dbReference type="GeneID" id="35406767"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13313"/>
    <dbReference type="HOGENOM" id="CLU_016624_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF9">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484626" description="rhamnogalacturonan endolyase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="13">
        <location>
            <begin position="361"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="12">
        <location>
            <begin position="450"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT67126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="670" mass="75345" checksum="B87096C3FC7EBCF9" modified="2013-09-18" version="1">MKFRKLSAAFLVSLLQAPQLVAATLNATETDTQLVISNDRLYAAVQKKGGAIVKLTLDGTNLLGSPSGSTGIGPYLDCYCTPKGFWTPGSVAPKYKLFKGKDGKGKDYGGIVMSDTYTETGQVLEQYWFLRDGETGLHTFSRVAYHNEEQPFLRNLQELRTLFRPNNDMWTHLLTNTKQYAPLPGKEAKEKQVVVQDATWYLGNTPNDPYVEQEADYFTKYTFQDSWRDIDAYGLFADGSKTEDGDAYGAWLVMNTKDTYFGGPLHSDLVVDGILYNYISSNHHGDQTPNITNGFDRTFGPQYFHFNRFPGETDILKAQADAAQYADPEWNADFYDSIAKHVPNYVPTKSRGSFEVKVDLPKGAKNAIAVLAQSGVDFQDNVFDTKAFQYWANLDESGRATIPRVKSGTYRLTVYADNIFGQYTQDKVKIKAGKTEKKNVRWREESAGKELWRIGTPDKTSGEYRHGFEPDTSKPLQPEQYRIYWANWDFVKDFPDGVNFKVGESDVGKDLNYVHWSVFGGKGNSVRPDQYVGDGNVNNWTIAFDLKESQVKHKKHATFTVQLAGAKTAAGNTDIYNASEPHSNLKYTVNINGKDLEPWVIPYDHSSSCAVRSSVSCYNIAHKFEFDAKLLKKGDNEIILSLPYNATNYESAVLPTSVYVQYDALRLEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXU5</accession>
    <name>S0DXU5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_03211</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428283.1">
        <property type="nucleotide sequence ID" value="XM_023575033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXU5"/>
    <dbReference type="STRING" id="1279085.S0DXU5"/>
    <dbReference type="GeneID" id="35396693"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03211"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="259"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="515"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="182"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT66202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="571" mass="64186" checksum="8A6A7CDA8104526B" modified="2013-09-18" version="1">MPSLGFLKKKRTREGNSDPSASSPTSPVTPTTSRSKSISKAFHLPRTSRQSTSAPSAQPTNGQSQQQQQQPDQIQEGAVSQSNQSSAPNEQTTAATDGQQQEDMSAINLHQPSYGAGSPMNHDHQNLPSINNLINPPQQQQQHNAQGNSYNNGQTNPQYLAATIDSHRPQTVSPGTDPAALQQQQQQALPQPSMPPQQQQSQAQQQHQQPPQQFQHQQNQSQNQAQQQQQYQHQPHHQQNASTGSVMRVTKGKYSLGDFDILRTLGTGSFGRVHLVQSKHNQRFYAVKVLKKAQVVKMKQVEHTNDERRMLADVKHPFLITLWGTFQDPKNLYMVMDFVEGGELFSLLRKSGRFPNPVAKFYAAEVTLALEYLHSKNIIYRDLKPENLLLDRHGHLKITDFGFAKRVPDKTWTLCGTPDYLAPEVVSNKGYNKSVDWWSLGILIYEMLCGYTPFWDSGSPMKIYENILKGKVKYPAYVNADAQNLLERLITADLTKRLGNLYGGPDDVKTHPWFAEVTWDRLARKDIDAPYTPPVKAGAGDASQFDRYPEDPEKYGVVTAPDEYGHMFTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYI1</accession>
    <name>S0DYI1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to D-arabinitol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429581.1">
        <property type="nucleotide sequence ID" value="XM_023576432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYI1"/>
    <dbReference type="STRING" id="1279085.S0DYI1"/>
    <dbReference type="GeneID" id="35407170"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13716"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="300" mass="31754" checksum="5B5F3CB6A886B95D" modified="2013-09-18" version="1">MSDPAAREDLTKRQLPSMTLARGIESLPSAAQARTALTSDDSLTRFQVQGVAVVTGGLGTIALTVVRALLQHGLTALMLLDLDVTSESAMSKVDDLRKDFPERKIEAASVDVTDEEAVGQAMASAVEKLGGLDFLVCFAGIVNCTHALDLSPKVFRKLLDVNTTGSFICAQAAAREMVKANTGGRVVFIASISAHRVNYPQPQVAYNTSKGALLMLKSSLAAEWARYGITVNSISPGYMDTILNEGEGLADARRSWAERNPSGRMGMPEELSGMVVLLCSKAGSFINGSDIVVDGGGIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYJ9</accession>
    <name>S0DYJ9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to hydrolase related to dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429702.1">
        <property type="nucleotide sequence ID" value="XM_023576518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYJ9"/>
    <dbReference type="STRING" id="1279085.S0DYJ9"/>
    <dbReference type="GeneID" id="35407950"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14569"/>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="251" mass="27435" checksum="88FAE32A74D47F61" modified="2013-09-18" version="1">MASNQPAKCCTEGVRHEGEPTGKMIKLDSGLDAYIATAPADKAHKGTGIVYIADIFGIWTNSKLMADQFAANGYTTIIPDLFNGDVMPMPMPEGLDIMSWITKGAKGDNPHTPAQIDPIIAESIKTLKAQGATKIGAVGYCFGAKYVIRNYKAGIDVGYVAHPSFVEEEELKAITGPLSIAAAQTDHIFPTEKRHQSEEILIGTGKPFQINLFSHVEHGFAVRADLSDKRKKFAKEQAFFQAVQWFDEYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ68</accession>
    <name>S0DZ68_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428768.1">
        <property type="nucleotide sequence ID" value="XM_023574120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ68"/>
    <dbReference type="GeneID" id="35395877"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02395"/>
    <dbReference type="HOGENOM" id="CLU_151392_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9698" checksum="90ED389B4AAFC657" modified="2013-09-18" version="1">MVLLNLLTLGLWSKVGRLTHYAFDAVLFSAFLAGMKRSTGLTFKTDKVAGENKEFTGWIDRYLGVGEWVMDQSVAIAGSSGYFERTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZA9</accession>
    <name>S0DZA9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429994.1">
        <property type="nucleotide sequence ID" value="XM_023576820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZA9"/>
    <dbReference type="GeneID" id="35408210"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14832"/>
    <dbReference type="HOGENOM" id="CLU_2454900_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495349" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="89" mass="9535" checksum="E5374468EC776406" modified="2013-09-18" version="1">MWSLTSTVVSVLALSSIALSAPAADIEAVSTLETRKSKACTKGNYYTCVNSWAGPCQVGCLREGPTIGKQVCENECAFEASKNCEKWCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZD8</accession>
    <name>S0DZD8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430024.1">
        <property type="nucleotide sequence ID" value="XM_023576762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZD8"/>
    <dbReference type="STRING" id="1279085.S0DZD8"/>
    <dbReference type="GeneID" id="35408158"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14778"/>
    <dbReference type="HOGENOM" id="CLU_051118_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF4">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="7"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="308" mass="34922" checksum="F01D6B0780CF2679" modified="2013-09-18" version="1">MTHPTGFEKLAAWTASIPDYEGFVFRRFDRLSARNLQHLESELTFLETKLDGLDQEAAASSDVNSLRTRYNWETFEELSKVQNSLTAERMEASKNISRKLKNYYEMLVLQSKIAAMEQPDKLQLAVVRKHFNHGIHPTEFLPNGRRNLEGQDYFRLDKDRELVALNPTSDKDLLSRFLRRHPGMLKVRLTLYQAPYRSWRYVKLANRTQSETLSTGEEYFDEKYISFAVSIVSIALAAILLLGAIISLRLVQDEKARIGMIVGFTVLFTASVSFLTNAKRADIFASGAAYTAVLVVFVSGDLGGSSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZG7</accession>
    <name>S0DZG7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_12962</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428878.1">
        <property type="nucleotide sequence ID" value="XM_023575591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZG7"/>
    <dbReference type="STRING" id="1279085.S0DZG7"/>
    <dbReference type="GeneID" id="35406418"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12962"/>
    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000009">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="137"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT66797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="429" mass="46901" checksum="B85378204B6208CE" modified="2013-09-18" version="1">MSSWLPIPSKSHFSLVNIPFGIISTSAEPTHRPAIAIGQHVLDLSAFAQNNGFSKLADFPADQLKVFSQTTLNDFAALGRPVHRATRAYLQDIFRQETPYPEILKDNESLRKQALIPIGDIQSHLPLSIGDYTDFFAGRNHAHTVGTLFRGAANALQPNYNHLPVAYHGRASSVVVSGTPLHRPWGQVLPNPQAKEPVFQPCARLDIELELGMFISKGNKLGAPVDVNSAEEYIFGYVLMNDWSARDIQQWEYVPLGPFNAKNFGTTISPWVVLADALEGFRGKGLENEVPPKKYLDEKREDSILDINLEVSITTAKGNKTKITQVSSQNLLWSWPQMIAHHSVSGCNLRTGDLLGSGTISGLEPGTQGSLLEQTMGGKQFVKLEGGEERKFIQDGDSITITGWSGTAEDGIVGFGECEGTIIAAVPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZT1</accession>
    <name>S0DZT1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_06867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430184.1">
        <property type="nucleotide sequence ID" value="XM_023577056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZT1"/>
    <dbReference type="STRING" id="1279085.S0DZT1"/>
    <dbReference type="GeneID" id="35400344"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06867"/>
    <dbReference type="HOGENOM" id="CLU_344533_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF14">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="29"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S12 Pab87-related C-terminal" evidence="4">
        <location>
            <begin position="389"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT68104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="821" mass="90893" checksum="C6CBF6669A3A3D0F" modified="2013-09-18" version="1">MVSYSRTNIHDAIVFLEPQMDYICKVSGATGLSLSVVSGGEEAYAKHLGFRDVEVQNTPDGDTTYFIGSVTKGIVAVLVGILVEEGKLGWSTRVASVLPELQDAFEGRGSQITIADLLSHRTGVARSDAIWISRAGNILLPKDFRNDFLYNNYAYDVEKVWEPMGMHRTSVEDLAGNSNAAKAYYALEDASSYEVPIPTISHETIMGAGGAIRSCTNDLAKYYCSFMKAVNHQFNNNTTSTPNSPFKQLTTILRPHNQLGVISLGEQSYALGWGRAQLPCPLGTLNYNYLLIPLMPVIGQGAPSQLTLYHGGSIQGFNTAAYLLPETETAIIAMQNSSGLGDACDWIPQIIMHTLSGSTERIGFLHLATVAVRAALSLPEKIDDELETRRERGTRHMNLEAYTGRYWNALQNFRIDVKILNGRLSMTFQGILNETYELRHYHHHLWTWNVSHNETAKQGRYPTKPWISYIIELDCGENKEAQVLLWKYDEEHPEPGVFRQALAQPRTPYSGRQGLRFRNHGSDLVDETTNPTAGQAQASAPANSDSQDVSTKLKIFSFWIKVYEEILADKDEQLKKILDAYDVLLERAAGTDGGIASSNTIQNQGDDVGFIKDSSSAEADIGDSSSSELSDSGIHLLPSARRVVGDDAKMKAIVKIKLDEMQQKEWVLKWPGHVFKVQTAALNPYAGLAWAGATELVARYKIVEEDYIYGKHGKHEDFEKILVAMYSKITLFYIKAACYFAKSTLKRMLRGVATLDDWKSTLTNLTKADEECQAFVVSLGISASLKKGRSDLGKAEQSRPALKSTESRHGFSMTSTSISNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZY5</accession>
    <name>S0DZY5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430171.1">
        <property type="nucleotide sequence ID" value="XM_023577042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZY5"/>
    <dbReference type="STRING" id="1279085.S0DZY5"/>
    <dbReference type="GeneID" id="35400331"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06854"/>
    <dbReference type="HOGENOM" id="CLU_057547_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="201" mass="22776" checksum="1A99C2FEF80D1D94" modified="2013-09-18" version="1">MVKEYFLAPHFNAPAPPRGVVKLGTILGRLDNFDPFNLEEFQPIPAAQLLPVETQDSVDIDIYGLHADRHPLTERALGLIGRGPRAPDRRPEGDHRVTSCKHLDTLAFIPIESYVRDTIDNLDDESYKPSSRSKRPVYMATGLKIAPEDFIVAFKVVQVWLDRKGEVKYKEYNKKAVMEFETSAEDDTATPFLFTSYPLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0M8</accession>
    <name>S0E0M8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428334.1">
        <property type="nucleotide sequence ID" value="XM_023575093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0M8"/>
    <dbReference type="STRING" id="1279085.S0E0M8"/>
    <dbReference type="GeneID" id="35396748"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03266"/>
    <dbReference type="HOGENOM" id="CLU_043473_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="308" mass="33971" checksum="8F78E19855019DD8" modified="2013-09-18" version="1">MASSPKYISGDAAAVSEFIDKFDVFLLDCDGVLWSGDHVYEGVPETIKYLRSKGKRTVFVTNNSTKSRDEYLKKLTNLGIPSEKDDVFGSSYSAAIYISRILKLPENKRKVFIIGEAGIEHELDSEGVPHIGGTDEAFRRDITNDDFKGIADGSLLDPEVGVVLCGLDYHVNYLKYAHAMHYIKRGAIFLATNVDSTLPMHHDFFLGAGSCHIPVVHATGKQPLALGKPSQAMMDAVEGKFQLDRSRTCMVGDRLNTDIKFGIEGRLGGTLHVLTGVNKKEDWEKADAIAVPSHYADKFSDLRLAEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0W9</accession>
    <name>S0E0W9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430390.1">
        <property type="nucleotide sequence ID" value="XM_023577298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0W9"/>
    <dbReference type="STRING" id="1279085.S0E0W9"/>
    <dbReference type="GeneID" id="35400562"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07085"/>
    <dbReference type="HOGENOM" id="CLU_036929_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="332" mass="36982" checksum="9E32F97FA6F46126" modified="2013-09-18" version="1">MSVAFEPRNFIHDGSYPPIGDDHDHGADQRFTDSDVAEQLSHYTTEASMLPDTTGVLGDDRGMMPEDAAAVQEATRLDLGPHSFPSPIEDALQAPSLDPLPDDKDLSPSIESPPPLSSRVKSIPKPERDAVKGADGKFHCTLDDCKEEVRVFSRKCEWNKHMDKHERPYRCPAEGCENLPGFTYSGGLLRHEREVHGKHGGPKNTVNCPHPNCKRHTGKGFSRQENLNEHLRRVHTNPDGSTPTEIVQSPGDNDSEKTGMKRKRHSSEQATEELTELREEVKRLKEENEKLRAEMNQNSQHSLSMMAQIAELQDALREGLGHPLGAPTAQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E109</accession>
    <name>S0E109_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_03398</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428454.1">
        <property type="nucleotide sequence ID" value="XM_023575242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E109"/>
    <dbReference type="STRING" id="1279085.S0E109"/>
    <dbReference type="GeneID" id="35396880"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03398"/>
    <dbReference type="HOGENOM" id="CLU_015631_0_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT66373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="485" mass="54789" checksum="718FC3EA40101AAB" modified="2013-09-18" version="1">MAVKDKQPASEEQHGYEFFGPPGAFVISFFLPILVYVFNFVCNDISGCPAPSLLHPKTLSLDALKHEAGWPSNGVAGLVSWKGTAAVIGYNVLSLILYRVLPAVEVEGTELRSGGKLKYRFNTLYSSTFTLAVLAAGTAAQGAEFPVWTFMSENFIQILSANIIYSYLVSTFVYVRSFSVKPGNKENRELAAGGHSGNMLYDWFIGRELNPRISIPLIGEVDIKEFLELRPGMMGWIIMNCSWCAQQYRNYGFVTDSSILITAVQALYVFDSWWNEPAILTTMDITTDGFGMMLAFGDIVWVPYVYSLQTRYLSVHPVSLGPLGLAGMLGLIGLGFYIFRSANNEKNRFRTNPDDPRISHLKYIQTQKGSKLLTTGWWGIARHINYLGDWIQSWPYCLPTGLAGYQILSAGTHAEGAWVMRDGREVIQGEAKGWGMLITYFYILYFAILLVHRERRDDDKCHRKYGKDWEEYRKIVRYRIIPGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0E120</accession>
    <name>S0E120_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to folate transporter/carrier (Mitochondrial)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_07153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430455.1">
        <property type="nucleotide sequence ID" value="XM_023577374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E120"/>
    <dbReference type="GeneID" id="35400630"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07153"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="49"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="154"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="282"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT68375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="412" mass="45186" checksum="A6831BACDCC8ADE6" modified="2013-09-18" version="1">MSSTDQVPPEAAQSPSSDYAASSYGYASSNAPMHSTTVTPLHRWALNASDTQFNAVAGAVGGFTSGVVTCPLDVIKTKLQAQGGYAALNKGRHVGHPKLYNGLVGSAKVIWREEGIRGLYRGLGPIVMGYLPTWAVWFTVYNKSKGYISQHSDNSHIVNFWSSIVAGASSTIVTNPIWVIKTRLMSQSNIRHNTQDHHSTYYPKAVGTPTARPTLHDWHYRSTLDAARKMYTSEGLISFYSGLTPALLGLTHVAVQFPTYEYLKTKFTGQGMGESNEGDDKTHVIGILGASILSKILASTATYPHEVIRTRLQTQRRPLAGEEFVQGMGVTSSGPRNRTPVEKPKYQGVVHTFRTILAEEGWRAFYAGLGTNMMRAVPAATVTMLTYEYVMRQLYHARAEARHLLLDPTAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1C7</accession>
    <name>S0E1C7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FFUJ_07334</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="11"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430626.1">
        <property type="nucleotide sequence ID" value="XM_023577575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1C7"/>
    <dbReference type="STRING" id="1279085.S0E1C7"/>
    <dbReference type="GeneID" id="35400811"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07334"/>
    <dbReference type="HOGENOM" id="CLU_030988_6_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="19">
        <location>
            <begin position="31"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCT68546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="185" mass="21080" checksum="62A26BE0CF806384" modified="2013-09-18" version="1">MLKIWSMKKEQKEAENAEGQATGGKKKKVTAAQLRVQKDLSELSLGSTMKTEFPDPDDILNFVLTIDPDEGMYRGSRFTFDFTINQNFPHEPPKVRCREKIYHPNIDLEGKVCLNILREDWKPVLNLNAVIVGLQFLFLEPNASDPLNKEAAEDLRNNREGFKRNVRTAMGGGVVKGRTYDRVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1E1</accession>
    <name>S0E1E1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to phosphoesterases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430754.1">
        <property type="nucleotide sequence ID" value="XM_023577738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1E1"/>
    <dbReference type="GeneID" id="35400958"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07481"/>
    <dbReference type="HOGENOM" id="CLU_041441_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="302" mass="34647" checksum="9C6BE3EAC21832FE" modified="2013-09-18" version="1">MLFGTQRTGLDVLLNRPRPNKWQQFWSKPYVFLAHFFYSLRHIAHEPPVNPVSIVCISDTHNSQPHLPFGDVLIHAGDLTQSGSLGELKATIAWLNSQPHTHKIIVTGNHDILLDKGCDRREESAAERECLDWGDCIYLQNETTTVTCRNGRTLKIYGSLLSPRHGNWSFQYSRSQNVWSDTTPNDIDVLVTHGPPFAHLDLNLGCHYLLKELWRIRPLLHVFGHVHEGYGQESVVFDRLQNTYEKALCDGTFWSLMRVFKEFLRLLPMRKKPAMTICQLVNPAMVGGLRDDEKRKAIKVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E213</accession>
    <name>S0E213_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to monooxigenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_14686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429778.1">
        <property type="nucleotide sequence ID" value="XM_023576647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E213"/>
    <dbReference type="STRING" id="1279085.S0E213"/>
    <dbReference type="GeneID" id="35408066"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14686"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF8">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT67697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="572" mass="64519" checksum="97983E8044B08BD1" modified="2013-09-18" version="1">MDPPKAEAIFNERFVKIICVGAGVSGLCLAYKLRRSFHNYSLTIYEKNSQVGGTWYENTYPGCACDVPSHNYTYSFEPKADFSSVLASSDEIQEYFEGFAVKYDLLKHIKTEQQVVETSWDQPKGQWNVRVTDLKSETVAEDWCHILIHATGYLNKPAWPSVSGLEKFKGPKLHSAKWDNSVSLDGKDILLIGSGASSVQILPTIQPRVKSAKVFVRTPRWTLPSVNSKKGKFSLEEIEKFVSDPESVMKLRLENERTLNSFFTMYMKGTILQKQAREHLESEMKKVVIDEEVQKKLVPDFPVGCKRILPSGDQFLYAIKNDNVQAIYSGVKEITETGCISDDGQHYEGDAIIAATGFDTSFIPRYPIHFKGHNLQEDWSTSITGYMGVGISECPNSFTLAGPWSPISNGPVIAPIEAQADFVCAFIDKYQTEPGMHSMSLKAAACYDFKSYMARVTKKMVWSDNCRHSHNIKPNWGQSSITWPGSTLHYLEAMREPRFEDYDFEYSGNRFAWLGNGLSQTEWDPTADLAYYVRDEDDGRHLSRGARTKVISKSGSQPPRELHRQAKLAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E378</accession>
    <name>S0E378_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431346.1">
        <property type="nucleotide sequence ID" value="XM_023578122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E378"/>
    <dbReference type="STRING" id="1279085.S0E378"/>
    <dbReference type="GeneID" id="35401302"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07825"/>
    <dbReference type="HOGENOM" id="CLU_007183_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="2">
        <location>
            <begin position="659"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="901" mass="100323" checksum="01579B8647A92CD6" modified="2013-09-18" version="1">MPGAPDVNKPTDIKTKEADVNRKLQVYGIISAFQNGKVPSNDQIDVALSSFLASRALSGRHEKLSAEGQELVKDAANAIKQAKHLLLSKNEGNLIQDFIWQTTQFDPKSVNTPNAPISKDAAKQDGDQALEGLRTLGQLLITNGQFRKLLSDATVLFRDMAGDAATNAAARVRPSQEQLRQIDEPAQDNVWHEAPDFSKDTLKQQAKGFYSGNPKEDAKDVASAGINAAAPGQLQQNQQSNAQQGTYPQVTTGTETGNVPASSDAARGAARQTDPQAGKSAAKQAAEAKIDNKIDPETKENILQRNEEYRRKARNYFDKKMPQERKDQTIWRLKKMILECQQHEDYSQAIQTLLRLAENYSRHGRTLGQGSTDTAKEARGGLAAAERDLRTIIERFANGTSTEDLWEAIGQIYRDADNDRELKDWFKAMDSYIRRCLLQQGYILEDESTREWDQLYDKGRYLLRNKYRGHTDRVVDEIKFLADQFDQDPQNHAFAESLQKLFKDLGNDQDGKPVFKPHLLKDLRDVILPAALENIAYIPIPRIEYTDSQVDAIIENLVLESDNFAPNIFEVSSEHYFRWGRKKIANKNHQTVEVKVAGIQMDLRDVSFHIKRKQGFPTITDTGVADIILPGDGFSFKMKVSTADKKDRQNYFKVEKVDVDFNKLQIKVKKSNHKLLFSLFKPFMLKVIRPPLQKAVEKAIKDQCNKFDQLLFQVKQEADRAAAEAKNNPENAPNIYNRYYTAAQQQFTKGKKKAEAAASDKKANIAMTKEDSIFPNIDLPGGISTKATEYKELARKGDKWESPVFSIGSAKKSTDIPSAPKIQRKAHPVSDLGSKNTSNADYDFYPAGGNTHTGNGALNGGNGLQIGNGAVNGKHPAGYTNGQTGLPTSQAPLTTGQINPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3A1</accession>
    <name>S0E3A1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_13376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429264.1">
        <property type="nucleotide sequence ID" value="XM_023576055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3A1"/>
    <dbReference type="STRING" id="1279085.S0E3A1"/>
    <dbReference type="GeneID" id="35406830"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13376"/>
    <dbReference type="HOGENOM" id="CLU_033441_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="156"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="280"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="573" mass="62973" checksum="1EA5570690484968" modified="2013-09-18" version="1">MDVQLFVYDLSRGLARQMSMGLLGFQLDAIYHTSIELNGREYVYDGGIIAIRPGSSHLGQPLEKIHLGTTNLPMDVIEEFLDSLRPIFTLEAYDLFHHNCNNFSDSFANFLLGKGIPEHIVKMPQAVLDSPMGRMLLPQLTQGINAGRQNGSILGLQQSAQTPSAKHGVKIVSNSAEFDRLMNGAKNSCAVVFFTSATCPPCKVLYPIYDELAEEVGEKATLIKVDIAQPQAHEIGSRYSIRATPTIVTFLRGEEENRWSGADPAALRGNVQLLVQMAHPVHPHERLRLPTFADSNAKPVLYAKVPPLDKLLVKMGDAVARKSEVQALKKYLEDRAKDGPSSAVIPEMNHLSSLVRDSVTTLPIDILFTIVDLFRCALSDPRVSGYFAEEKNHETVRTVLDFVNQQSGCPYALRLVTLQMACNFFSTPLFFDEIMRDNSLRASVILLISSSFLDESHNNVRVAGSSLLFNLSVANRRARQESKATLSGDDEIELAASVVEAIALEEKSAEALHGMLLALGHLVYGTPLDGDLPDLFQTVGAGEKILGKKSKFPDEKLIPEVGKELLGKGLRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3J5</accession>
    <name>S0E3J5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431484.1">
        <property type="nucleotide sequence ID" value="XM_023577630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3J5"/>
    <dbReference type="GeneID" id="35400861"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07384"/>
    <dbReference type="HOGENOM" id="CLU_1875603_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="136" mass="14802" checksum="CBBEFAA3E9587860" modified="2013-09-18" version="1">MSSLFAFVCLTPEKLRQFSIIQLSTLNPQLNHITSRHKTSSSQPQLPTQKPPIKMTQSKDQKIAETQANLPLPDQPPKASDWQSADARTVNVGAGKQEGPIGTDSAAQSGLREPATKGEEVDLSNVGREGVEKRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3P0</accession>
    <name>S0E3P0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429409.1">
        <property type="nucleotide sequence ID" value="XM_023576227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3P0"/>
    <dbReference type="STRING" id="1279085.S0E3P0"/>
    <dbReference type="GeneID" id="35406986"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13532"/>
    <dbReference type="HOGENOM" id="CLU_333455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="960" mass="98670" checksum="00BE4E55425C0132" modified="2013-09-18" version="1">MALSLLLTAQSAQAGPMWTGRMYGETHNASATTVSNSGDREKRNPGAFLDVRMENSQAPTAAHDGYGSGSGDQTTPRPVFETLNSTPEPNPLLSENQGDDKKKSPYSDLPEPIEVIPVQPTSDASEPTSEAQESTQEPGTKPTFTQNPSAPVFTTSIVPKDPTTVVEKPTSAGQSDYEPPKDTSVVSETDPVTKEVPTSGNEAPTSQPVNNATTAVPEVPTTEAAQKPENTETQSLSSTLDLGTLRPSDGGKTQPGAVEETTAPEAPSAPATTAPGNEQPTSAVEEETTTFAYQPTPTGYLTTKVPSDTAFPVNPKHPTQVYPKSPTTSEGPLKETSAPEAESSAGTTQIVSVVQPGEPQSQTTSDAQSQPAPTSDAAQPETQTPVSEPAQPSNPAPTSEVQQSYVPVETPGSQQPDTPAATTAPAQPQNPVPTSQPAQSQPGNPVSTAPSQPQNPAPTSEPAQAQPETPVTSQVQQPEAPAVTSAVQQPAPVPSNGQPQHPAPDSNTQPAVTAAPPTSTVPVSDPSSPVTTSAPKVVPPGTSANGVPTINPGVPTGTSAIPASAYASNVVDARTYNEEFAKLTPESSCMKGQAACINGQTGVCDDTGKFQLTPCNTKGEKCFALPLYNFEGGIKIVCEDPATAAKILGGTPSSGEENSVPGNGNGGKEQPATTSAAEKPAVPVVTVTTIVTVDDGATPEPTGEPAKDQPSQPAQQPSQPQPVPEQPTKPAPEQTSQSAPEEPSQSQPLPEKSTQPAPEQPSQPAQTQPAEAQPSQPSEEKPSQTNPAGPSNPQPTKAYEDLPPTSAPVAEQSTTSVPLPGGTTLTKSIKKPDEAKPTGSPDDDDNKGKDGNGKGKDGHDGDDDNDDKPTSVVLIPIPDKPTDAPSPAATEAKVDNQGSKNDKKPAAGTRTGDDAHATTIVVDGTPTVSVYFTVTVTEKDQATVTVTEKEKETVTLVISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4C9</accession>
    <name>S0E4C9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to vegetatible incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_05483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431666.1">
        <property type="nucleotide sequence ID" value="XM_023578699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="35398962"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05483"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_7_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="288"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="568"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT69586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1410" mass="161568" checksum="27936798DEFFCDB6" modified="2013-09-18" version="1">MTSSSCLWTKARENLPADVKEWLASLEYGIQPSATATEQIDALIEQTTTKQKDLEKSNHRFRKYFDKIIYWLDKVKGIGDVISSFDPVHAALPWAAFRFALQVILAEREQTDSVLQLLASTPHLVFSGRVLERVYTNESINSQGPQEEVEIGQQCIDSLHDELIKLYCALLGALKYCHSIVSQHKVKRKATAIFNSSEVASIHKDLAAQHTKVLSCGETCHKFLSHVLSRKSLDLLAQVQPSLAELGDRVRELLVQIDVSERRKTLGAISSVMFRSHHEEVSRKRTKGTCEWILRKNKFIQWEESDSCIAILYGNPGAGKTFIISRVIDYALEKAETSEGLAFFYCKRDEENRRNPQDILRSILRQLSTPVRDIESGTIHAALKNLPNKLALKGTTINVSTCENLLGELVEDYPRTTIILDALDECDRNTREELMRVFSNLASRSSKVRVFISSRHDEDIQRHFKNTPIIEMLATDNEEDIASFVEEKLLRDSRWVEISPELQKEIKARFHEKSLGMFQWAALQVDQIRRLKLWSEANIRQQLSISPTGLDAAYEVVWNQIHEMSSYEQQLARRAFQWTLCAFRPLETPELSLMMHIDPDSGKKESDTVLEAETIQCICGNLLVYDLQSEVWRFSHLSAREYFENYHFNILQCHYQVTISSIKFLERDLVWLPPDEKTQIVSPFRIVAPIRPDPNSRCVEYTATCDYIVTNVFRHAHELDTPEFRHIELSNLLQNFFEPISKGSSSFQAWRRLSIEKESSRSFLNTTSRGSPIWEGLLATPLQVMSTYGLFYILRGLWEKSEGEWDSFPKWLPSPLTLAIDHGHEYIWNFMLLAKANVNSGIPRPLTAAIRHEDMEAFEALLEAGADVNNVFLQPSSLEALSDLRNSCHMEPDEPLKTALWVFNNESRRYFIERLVDQGADVKLRTQFESVLEIAVEYADEETVGILLNANTEEYSPDHLLRLAAQNKIFNLVPLFVKLGANIEKPWEGVLPSVWALRQGNLPNVRSLLEMSDTQMDLSCHKTREAFLSALKTNCGTEIFPVLSNAGVSIDGRKVEADVFDRALTLYSRYERKLRLYPAHGPLPSPYLKAKSHHELSFFGTLLEALANFSDRTDVGFGSVLAGAAFHGRIYHCRAVLDHGEFHTEQERQDQFRNALFAVIRGHLSFRSRQSADDWWRPLGYEILDPRHRRVLRLLFKRGLEVYMPIYDSLAPSLPVVQINLAGYEVSEPCLMYGRDHYAYFSRFWLFIMWHLQNSTSPQLPIRSQLRRWQFPGMLSPTFTIVANLTAASGAQSNYFIKLFIRGNHSQFIISPASTEARRSLSHISDDKRWKRYKPESFGVIRYSYHDLGVETSNTEDAIASRKFEAYQDSLRGNNMVWIFLALIVGLFSCFFCSTSVDQGILVSISNVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E529</accession>
    <name>S0E529_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431875.1">
        <property type="nucleotide sequence ID" value="XM_023578954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E529"/>
    <dbReference type="STRING" id="1279085.S0E529"/>
    <dbReference type="GeneID" id="35399190"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05711"/>
    <dbReference type="HOGENOM" id="CLU_027206_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF51">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="130"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="470" mass="52248" checksum="A6DCC067CD0D11BF" modified="2013-09-18" version="1">MSTAQDYYSDEWTDTDSEINSDDLMAIDSDDGSDDGSDAGSDDSSDDDSDDGSELDRDVFGPLVDITEESIIALATRVAKDVLHVVPGKAELLNTVSGSYNIVHIVQLETVKLVIRIPATGWGDGMTKAAEDALSSQVATMRFIKEQTGAPVPEVYSWDPTNNNEISAPFICMSFVTGETVSSVWFKDSMDDEAREQLRLNILTSIATIMAKFSSMTFDKMGSLMQAEDGSFFLGPMFEWVENDDDSVHAKATRTYFSMDELFACSIESGSTGNAWDRAEDKLLKVFLENSPLLHYHSRFVLCPPDFDSQNVLVDEKGNVTGLIDWDHCQTMPPHLGYAAYPGWLTRDWDPLMYGWPHYQKTEDSPETLQRYREHYNKEMCKALSGQGDCGVTQDSHIAEAIAIAAFNSMNRLEICCKFVQVALGIDKDDSISVVLDIGEDDYDKGKWNELEDKLKALVCPSTTPSRQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5H3</accession>
    <name>S0E5H3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to pig-c protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_05944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432090.1">
        <property type="nucleotide sequence ID" value="XM_023579212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5H3"/>
    <dbReference type="STRING" id="1279085.S0E5H3"/>
    <dbReference type="GeneID" id="35399422"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05944"/>
    <dbReference type="HOGENOM" id="CLU_024002_1_0_1"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT70011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="456" mass="50662" checksum="2AB48234160753FB" modified="2013-09-18" version="1">MPPPTDDETPFPSLDHSALHGFGRSHLSPDDAFVSPPRGPRGRSRRRKRPWKKLMWVKQSYPDNYTDQATFLENLQRNPRLKPYDFWPLVADSTVILQHVCSVIIFVVCFVGIFQERVSPVAVTSWSSFATFVGWILWERWLSEIEDTDDPSLGVAANVMGRAGRTGSLRRPTRTGSIRRPPPLRVESAPSTAAPSAVASAASSTTNLHAPSTMHRAQSASKTSLASGIAHTPRASQEHLPELPPPLLAEENRYRQRMETVKSAILIYCTLLGLSPILKSLTLSTSSDSIWAMSFWLLAINIFFFDYSGGVGAKFPASLSTNAALMASTVLASRLPSTKQVFSLTLFSIEVFGLFPVFRRYVRHRSWRFHILSAILLVLGASFGVGLILGYDKNTVGWPWKSGLVGMIVGMLIAILATGGCSWWLIGLQKYKNEIRGPWDPARPIIMNRPRWDDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6A7</accession>
    <name>S0E6A7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431347.1">
        <property type="nucleotide sequence ID" value="XM_023578125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6A7"/>
    <dbReference type="STRING" id="1279085.S0E6A7"/>
    <dbReference type="GeneID" id="35401305"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07828"/>
    <dbReference type="HOGENOM" id="CLU_041307_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="456" mass="52017" checksum="F36A2F0E16BC85D9" modified="2013-09-18" version="1">MSWTQRSNPYDAFAQEATQTPLAVAFPQWMLNIWEVTHDHPEGRWYLEPNARCLRQRASLRIVFAPLDLPRRDALSQFVELFSILNIPSDFTKERLQSVSHSFGRSTDAHGSSSWFHFLCKNIDIKQTHGNAPEIDNRAATMGYHISTLPQADYSWHRAGFFLRVDNNGCITLVCFGVMQKVRERINEFVAAKAWQHVATDPYILFDLVFEALYFEVDNTVWKMNTVFGPLEHLILEYANSKNIRKMSSKVPFSAMHNCAKHIIHIAEAIDSCILLVDATLHNVGNHQHSEQPTLREPIIKQLRETLQYRRSLFMSSQLRLSSLQKRIDNAITLSFNLVTQQDSMVMIQDSNSMKVIAAITMIFLPTTGVATVVGSQLFTSEILKDGTSWDVRLTPLFWTMLWISIPLTVFVVLLAIIWHWWVHTESPTGEVVQVVKRAATFSSSGTRTPPNGNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7A6</accession>
    <name>S0E7A6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432820.1">
        <property type="nucleotide sequence ID" value="XM_023579029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7A6"/>
    <dbReference type="STRING" id="1279085.S0E7A6"/>
    <dbReference type="GeneID" id="35399257"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05778"/>
    <dbReference type="HOGENOM" id="CLU_094004_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="151" mass="16973" checksum="C612BE9FAFE5C11C" modified="2013-09-18" version="1">MASASGVLIDQDCITAANDLRFAKGSSKIKFVIFKITDDEQRVVVEETSPDAEYETFRQKLLSAVDKSGKSAPRYALYDVDYDLGEDGKRTRTIFISWVPQTSSIKLRMLYASTMEYLKKAVNMSVFIHADNQEDIEWEELVKTASGGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7F9</accession>
    <name>S0E7F9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_05381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432880.1">
        <property type="nucleotide sequence ID" value="XM_023578586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7F9"/>
    <dbReference type="STRING" id="1279085.S0E7F9"/>
    <dbReference type="GeneID" id="35398860"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05381"/>
    <dbReference type="HOGENOM" id="CLU_009184_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="343"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT70801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="842" mass="92889" checksum="337E7720DA8AC723" modified="2013-09-18" version="1">MGIRFKNNRDDQVRSRVSDALNGRRNVTVKDPAMAAFGSDCAYPATENINDWGPNEGASPTEQSFLPSSAQEIQEQQHESMAAQAEDDTSPFQHETRSESLSLGGSAGTVPLPTTSTVDQVHGSQITDEDCHAGPFYILDDEPTISPTIDIPQPFNVLPVDPTHTVFEDTFALSPSSILPGQTSFRTGGFDWLNFDIGNSPQGFQLETFYNSYIPEFWSSSTAQQVPESGEPGSGDVGNGVQHKMGNGNSSRDSQDEGQPDIEQNTLAWPFDQAHKQSPHRYQLPPLRDILNGYCPTDRPRPVQTTLVKGFIQILSENPLPQLETLRDPHSIQAFCSLQRLVDSYFSRFHDIQAIIHKPTWTMSACPPILLTAIASVGALLSDSQSDYELSVALSEICSTMINWMVGFHFLPTGASDATNYSDVSYLNALCLYQIYSLGSGKRQLYQNADRSRGLLIGGLRGIGLLNPRSSVALSQDHETIRGYEDDHVLMKDWKEWIRIESGRRASWAAFEYDCSLCTLTSRRGIVDLSELPSELPCPESMWNATSARAWFALMSRLGQDDSKPNLSRVLKQALAGKELPSSLGSWAKRLCAQVIGRLLWDLWQIEVVAMPEYLGLGSIVAAHQDTKRSLLKGLNNLVESLSSPLSTSDLTSYNIASLLCHYSHLCAANGVLDLILSIVRGLISTEPRVHDGIKIARNRLKLTFARDPKTARRLCWHAAQIVAIANEYLVSAPCEIMRVFMGYIFIIAYSAYGDHTRSSPMEVTQSVRLDLHDQNLSHRRVVVRWIEVGGPASSGSVPDIGADGCVPAISSDAQEILKKLQCWGLAHKFTKVFQVLEAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7T6</accession>
    <name>S0E7T6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to cyclin-dependent kinase inhibitor 1c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430593.1">
        <property type="nucleotide sequence ID" value="XM_023577536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7T6"/>
    <dbReference type="STRING" id="1279085.S0E7T6"/>
    <dbReference type="GeneID" id="35400777"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07300"/>
    <dbReference type="HOGENOM" id="CLU_577524_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="489" mass="53539" checksum="7FBD239318B0A32A" modified="2013-09-18" version="1">MRYNALAFMALVNGLAQANRFDWQSESKADVAKHEHKNAADPVFKVEVNKGQLEAGKLKKEGEKAEQQAKKLEEKLQKKEDELELKAAQAGGNRHHHHSHSSYSPDPTYDPATKTTGYHHHHSGHLQKGPYTLDGEKYDYIHKPKVHFHTSYTTHAPTLSPGCVGDKCSRKPCKECHGNWAQPGCWHCKALGATGEEVAEQVAKTTKHAPKETKAKEEEEEKKEKDPHAKTYTHGDKTVIVPKETKAPEATRPEAPQIEQPHKEGPKVIVIEDPKKKPEEKKSEEEKETYHDEKPKHEHPKEEPKKEDICDKVHHHGQPSICDKIEHQHHKVDEPKKENICSKPKGCHPHQAPVPAPAPAPAPAPAPAPAPHNEVKPAPAPAPVPHHEVKPAPAPVPAPHHPEQKPEIPPVPIPAPAPQQPEQKPGEVQPAPAPAPVPAPAQPEGAKPEEGKYGNAPSVPVTVPKSGATYNRVSVGVAVFAGVASMMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E847</accession>
    <name>S0E847_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_07447</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430723.1">
        <property type="nucleotide sequence ID" value="XM_023577701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E847"/>
    <dbReference type="STRING" id="1279085.S0E847"/>
    <dbReference type="GeneID" id="35400924"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07447"/>
    <dbReference type="HOGENOM" id="CLU_1408877_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT68643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="193" mass="20830" checksum="EAC1B6B13A1B9108" modified="2013-09-18" version="1">MFILEDGATLRNVIIGPGQTEGLDCKGTCTLENFRPAPPPSVEEVLFTPPIRLFSSTAAALTRSPTFKQGKLVRSCGNCKDNYGPRNVVTDNVAAVNGGVLCGINTNYGDTGTISNACQDSGKNCDLFDNFDYTLKGFNSLTAFPSSHPVFSNFMKDVQINEAQEAIDPVAEFPFEDSFKSATNIKSREKVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8Y3</accession>
    <name>S0E8Y3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_07760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431013.1">
        <property type="nucleotide sequence ID" value="XM_023578048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8Y3"/>
    <dbReference type="GeneID" id="35401237"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07760"/>
    <dbReference type="HOGENOM" id="CLU_004495_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT68933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="528" mass="56305" checksum="0E622CD708C6A9F2" modified="2013-09-18" version="1">MESATKSGDADQALARLGYKAELPRNLSMLSVLGLSFAIMAVPFGLSTTMYITLTNGQAVTVLWGWVLVSLISMCIAASLAEICAVFPTAGGVYYWSAMLSTPRYAPIVSFVDGWLTLVGNWTVTLSINFSGAQLILSAITIFNEDFVANTWQTVLCFWAVMLVCALVNAFGSRYLDLINKVCIYWTGASVIIIIVTLLVMAPSRRSAEFVFTHYDASASGWPTGWSFFVGLLQGAYVLTGYGMVAAMCEEVQNPEREVPKAIVLSVAAAGVTGIIYLIPILFVLPDVKMLLSVANSQPIGTLFKVVTGSAAGGFGLLFLILGILMFAGIGALTAASRCTYAFARDGAIPGYKLWSKVNHRLDMPVNALILSTVVDCILGCIYFGSSAAFNSFTGVATICLSSSYGVPVAVNMVRGRKIVKHSPYPLGKFGPLINGICVVWIVFSIVIFCMPVSLPVEPGTMNYASAVFAGFAAIAIVWYAAYARKNFTGPPVHDDGSFEPGVQVLKGQEGSAPVHEGASDIPEKDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9D9</accession>
    <name>S0E9D9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433364.1">
        <property type="nucleotide sequence ID" value="XM_023580618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9D9"/>
    <dbReference type="STRING" id="1279085.S0E9D9"/>
    <dbReference type="GeneID" id="35402132"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08656"/>
    <dbReference type="HOGENOM" id="CLU_397425_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="666" mass="75877" checksum="CE307BF34EEB24E8" modified="2013-09-18" version="1">MAGLPPVRAMPQNTPAPMHHTQAPQTRSSMPQQNGAPAGLPAFMPANTRPYSHPPQPPMDLRLQDPAEIKNARSGELPMYRALRLEKTPGASGGGKARDTEYDWETITRTDKNMSQSRIKERIEHLDRTTRSVSKKKQDKNETIQLQLDRAQADLTKEDRDFRFYYKLAQIESEWRAADDPRHWDDRSVRSSRKHRSHSKRSKSPRLERVAINAYFQRMPASGRHGSRAIDTHVSMRQPRQIQQTPTQPRMRGLPPVTLPQGFVHPPPPAPTAAAPVRPAPPPATDPRLNGQLRPPMGEQNVPRMPQAHSLRQGPFNNAQQSGMPPAKPGNGVLHNAGVVPPIPVPAPAQGQVPARPPPRLPAINIPIDRPPHGPLPGAKAPPQMPSSSPSAPKTPFEADNRSPKKMAPEPGFKFEDKVKVYDNSGRSSSPSDGDSDEWSEDESEDTRPSSVDSGSSPQRGRGRSPNPKRMPSDHHENIIIQDSRNLRKDAKHMADDRSFRDSDQQHVRFNSPGRRYRDESCSPRGGYHSPREQPWKGEPPRIIQAARPSVRHVRGTAPRRDNSYDIRPSHSDKPLERARLDDGHRERDVRRDNDRFKHLEEDLWRRRELKERREDGRSDDYKYADPEPRWSNQRAREYMSHREPRYSRQHHEDREAFRRYSGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAY8</accession>
    <name>S0EAY8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433011.1">
        <property type="nucleotide sequence ID" value="XM_023580191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAY8"/>
    <dbReference type="GeneID" id="35402515"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09041"/>
    <dbReference type="HOGENOM" id="CLU_813936_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="341" mass="37955" checksum="F26A1DD94FDC2A8F" modified="2013-09-18" version="1">MLKNKKRRDMSRTQDALLRQPETLPVALIVSERIKRANCPRKRRARSSRRMRSDVCFPSRTSTKVFCCIDQGPPKMHSYSLASIRHDEVDSLEDPTSYDGALDVDSSHQPEAALHEIMEKEKVYRHDRRSSRPRVALNATGALQCLQVHSATQTSPEASSIAIQSLIHDTELQIAADDIPFNQLYTRPESPPFDDSFAATRFHLGHLSHHHHTRTEISVQYETSPSTKPAKFTPHACPSPAFSTTANRGTHDSDVNSLLLHLRFNLRSPNLLTIAIDPAMNSQVADGMQQALLMRSATLVSPNATILSTRPSLYKTTLLNGGPSMILAALVEAPHHPANRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECR5</accession>
    <name>S0ECR5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to amino acid transport protein GAP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_08308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433681.1">
        <property type="nucleotide sequence ID" value="XM_023581007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECR5"/>
    <dbReference type="GeneID" id="35401784"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08308"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="62"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT71602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="561" mass="61138" checksum="F6AA5FA34A7C57B5" modified="2013-09-18" version="1">MRRESIHDVNIPAGTTEKSRGSMTKDDGLDLAASRSIDEVQAIEMQEGKHGQFHRSFTPRQVHIIALGSNIGSGVFIATGKALATGGPGNMVIAYFMVCTCVWAVLQSLSEMTIAFPVSGNYIDYADRWVDPALAFGAGFAEWLGWTAIVSAEAGFFHILVGYWSGGSFPLAASLSIFMFACLVIFLLPNTVFAWFEYVTSLIKIFLFLIIITLSLALVLGAGPNGYVHHGETWTDLPAFLNGFSGFANCALLATWAVGDQVFIGIMGGEAESPRFSLAHATKLVPFRVNFIYMLSVVFITILVPSNDPRLLGGGGVAASPFVVAVTDSGIPGISSLLNAGMICGVLAIAAESVYLSSRVLRTMAHQGLISTRLAHVDDKGRPRLALIITSVVAVVLGYIQLSAGGLTVLNWLISITSASFFTNWIIISFTNYRFHCALKAQNDKLFSETYAWRSSAWPIAPAWLMLISVMLLVCCIYSGIKPVGGAGFSASNFFQYMIGVLVIFGFTAGYKVIFRTPWRDPATADCLTGRRHLSVEEIKHLDEYYAKPKWRRFLTYVQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECS0</accession>
    <name>S0ECS0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434824.1">
        <property type="nucleotide sequence ID" value="XM_023582268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECS0"/>
    <dbReference type="STRING" id="1279085.S0ECS0"/>
    <dbReference type="GeneID" id="35406094"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12638"/>
    <dbReference type="HOGENOM" id="CLU_011786_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04842">
        <property type="entry name" value="Peptidases_S8_Kp43_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034058">
        <property type="entry name" value="TagA/B/C/D_pept_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="206"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT72746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="653" mass="70151" checksum="0BC4276681549D9B" modified="2013-09-18" version="1">MSGPTINGNAFSVSSLPDGPEQPGGDEMRVNHLPENTNYIVLETQDPLKRPEKRTLQDLHVELHEYLGGNTWLCRYEPTDIKSLRDLAFVKDAKPLQPELKLQPALKDGAAESRTVDIVLQNRADDSAEDISQRIQDSLGISPEDITIRDGASVIRLTGNNDKLQEIAKIDSVGSIQEVHKLTFFNNVAREILHADVSGSNTVFKGANQIVTVADTGFDTGDENKTHDAFTGRVKKLIPIGRSDKTNDPDGHGTHVCGSVLGDGHSEKMGGSIQGTAPKATLIVQSLLDRRGGLFGRSEKTLGDLLKEALDHQSFIHTNSWGPVWARQLEYNNASTDLDTFVSNHQDMTVCFAAGNDGGEETDLGHIGAQAAAKNCIAVGSSDNRRKAKNNRFDAFKADGVVEGNPNSISWFSSRGPTLERRIKPDVVAPGTMILSAMSRVAQPNATYGRSSDPAWTFSSGTSMATPLVAGCVAVLRESLQKDGVTSPSAALLKALLVNGAVDTGNSFEAQGLGRVDLANSVILNGITTNKGYLEAEVLDEDDQDEFTKTLTLGDLLMPDGPDSETVTLKVTMVYSDLPGAALQNNINLQVAVGDAPSRFGNLGDRPDDVNNVEQVIWSGIPAERDTKITLSVTAPRTMCGDKQAFALVWSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED35</accession>
    <name>S0ED35_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to 4-coumarate--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434929.1">
        <property type="nucleotide sequence ID" value="XM_023582388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED35"/>
    <dbReference type="STRING" id="1279085.S0ED35"/>
    <dbReference type="GeneID" id="35406202"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12746"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF265">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="448"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="543" mass="59501" checksum="50CA39E6F3F56378" modified="2013-09-18" version="1">MFSSPIPSVSIPSTDLLSYVFGGSDPVDPCLPILISAENPDHENISKPQAKDLVQRLARGLQVAGFQPGNTICLFSSNNIYQPIISLGSVAAGGVWTGMNPGLSDGEVKRHLTNSNTRFLFCCPTLLAKALRGASECGIPKANVFTITPLTTKDPTQNPWTSLLAHGSSPWTAFDDETKAKSTTACLYPTSGTSGLPKLAMLSHHNVISAAVLLNEVERRDYQVRQVMLWPMFHAASLTWSHITPLRQGWQTYIPSRFDPSKFLDIAGQFQCTDTGLAPAMMLAVLHNDLPDHEKRRKLSSMRYGVCGSAPVGPELERRWREIIPSNCPWSTAYGMTELSGVVSKVHYPVHDNTSSVGALIPNTEAKLFDDEGIEITAYNQPGELFIRGPTVFKGYYKNRVATDECLESGFIRTGDVVYIESESKKLFILDRKKDLIKVRGFQVAPAELESELFSHPGVAEAAVVGITNASGMECPRAYVVRRQGSMVSAAELVNYLGSRLPSYKRLTGGVCFMEALPRNANGKLLKKELRELAAREHRSSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDA4</accession>
    <name>S0EDA4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434663.1">
        <property type="nucleotide sequence ID" value="XM_023582075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDA4"/>
    <dbReference type="STRING" id="1279085.S0EDA4"/>
    <dbReference type="GeneID" id="35405921"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12465"/>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="53"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="239" mass="26445" checksum="F9AD8E566055CC99" modified="2013-09-18" version="1">MATVQFGILAFAYQVIDASGPMDLLNSANKTAFRINREYGPVSDELISQAPQFTFHHIGVTRDPVKLGTGQMTIIPTATVDDCPELDILLVPGPYLGNFDLHPKHADFIRKHVAAGKLLFTSCTGASLVASTGVLNGKTATVNNIEFDWVRNRWPQVNWTREKKWIIDGNIWTGSGAVAAMDMVAYWLKENYGLPVLVQAASTLDYEPRDSDGLFCVLPQRCDSKGEKTSTHVFKYYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDJ0</accession>
    <name>S0EDJ0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to phosphoribulokinase/uridine kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434778.1">
        <property type="nucleotide sequence ID" value="XM_023582214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDJ0"/>
    <dbReference type="STRING" id="1279085.S0EDJ0"/>
    <dbReference type="GeneID" id="35406047"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12591"/>
    <dbReference type="HOGENOM" id="CLU_067202_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="229" mass="25870" checksum="3B0366A63B80E1F2" modified="2013-09-18" version="1">MDAIYAQLERRALSLLHQLHQQSPDARAIIILAGPPGSGKSTIASQVVQRINSLHRTPIAKVLPMDGYHYSRSHLDSLPNHVEAHARRGAHWTFDGQAVLGMIKQLHESRERPLTTLYMPSFDHDIKDPIPDAIEISPDVKIVLVEGNWLLYNEYPWNQIANFADDTWFVDVEPQLALQRVAKRHVACGIERTLETAMGRARNNDMKNGEDIRRGLIQPNIIVKSVQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDM5</accession>
    <name>S0EDM5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435042.1">
        <property type="nucleotide sequence ID" value="XM_023582518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDM5"/>
    <dbReference type="GeneID" id="35406318"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12862"/>
    <dbReference type="HOGENOM" id="CLU_1749807_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="149" mass="17010" checksum="AF4340D1D962F6DF" modified="2013-09-18" version="1">MSNGSLSNASRGRAPLSSTHATLVHLALFLLWYTLTSLTLLLPDKHMNTTPGHPYAWQLLITSLQEELSRLCTQIPDGRLEEYLYIVAGQRCIDAADLTPELFAHYERAKNIRMFSLRERGIMAVRVSLYLDLLLYTKKTVYMAKTYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEU3</accession>
    <name>S0EEU3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(II)2Cys6 transcriptional activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432982.1">
        <property type="nucleotide sequence ID" value="XM_023580156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEU3"/>
    <dbReference type="STRING" id="1279085.S0EEU3"/>
    <dbReference type="GeneID" id="35402547"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09073"/>
    <dbReference type="HOGENOM" id="CLU_013866_5_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46746" checksum="A437F6BA2D7ECD7F" modified="2013-09-18" version="1">MQKALVQRRASRLPYAPQWSPDVSSRHSFLSLFIGTYSSAFDILPALLADSVPDGSLQLSVDAASLAFMAFQLNRFDLIPLANKYYFRAIRSLAMAVQSSIQPTSNAPSQSLSAMALQSVLLLDFYDKMAFQHYQPSEAPGLLQIHAKGSLSILRSLPKGELRNPATLQLATQSILVTILSCGADATDFPEHLIGLYNELGSYIQSDRWHLIGHYIRLVNIHINVRNGKMGLSDALKRAREYSLDIVEEENKMSRLWRPYRRDTCEARAFDSHYDAYPNHKVAQALNKYRIMRLGVASFVHRLTGSVEVAEDVEQLVRTICASVPQIILPEARPQNTLPFSPLQILECSAVLSPLYLCARHTRDPAMRAWILQTLEYMADNGVKMAQTLANIIESPLKPEIWDWFRMVGSYTCSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF30</accession>
    <name>S0EF30_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to GS1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435634.1">
        <property type="nucleotide sequence ID" value="XM_023568435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF30"/>
    <dbReference type="STRING" id="1279085.S0EF30"/>
    <dbReference type="GeneID" id="35403108"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09640"/>
    <dbReference type="HOGENOM" id="CLU_045011_13_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000131">
        <property type="entry name" value="HAD superfamily hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="310" mass="34655" checksum="269103FBB9C4D62A" modified="2013-09-18" version="1">MAPRTDFPPVRACLFDMDGLLLDTEDIYTKCVNIILEKYGKGTLPWSIKAKLQGRPGPQANKIFHDWAQLPITSEEYVAENTMLQKQLFPHTKPLPGIVDLLGHLGRTRYWEVKDGATTEAKDKSSSEPQRVHIALATSSHLGNFRVKTNHLEELFSVFPSHRRVLGDDSRLTPGRGKPLPDIFLLALKTINDSLSAGERPITPEECLVFEDSVPGVEAGRRAGMRVIWCPHPMLKKEYDGREAEVLAGRTGEAGEVDLHQVGEIDDGWAEYMLSLADFPYEKFGIVVPPVEVEKEDCMKEVPQEVVAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGC0</accession>
    <name>S0EGC0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable starvation sensing protein rspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_09331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435922.1">
        <property type="nucleotide sequence ID" value="XM_023568779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGC0"/>
    <dbReference type="STRING" id="1279085.S0EGC0"/>
    <dbReference type="GeneID" id="35402800"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09331"/>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT73844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="383" mass="42769" checksum="A1A0D13B4ABEDD06" modified="2013-09-18" version="1">MAKITSVKYYRVKPRWLMVKVVDENGQYGWGEATLEGHDLAVEGCLDEMIPRIIGQEANDIENIWQTFWRHGFYRGGPVFMSAISGIDIALWDLKGRNLKVPIYELFGGKVRNKVQVYCWIGGDRPSDIEAAAKKRLEQGLTCVKMNATEDLGWIDSPSALDSTVERLKQVKALGLDAGLDFHGRCHKAMAKQLARALEPHRPLFIEEPILVEHPEAIKKLSDQTVIPIAFGERLYTRWDIKRFLEDSSVDILQPDIAHAGGISETKRIVNMAEAYDVAIAPHCPLGPVAFAASVQVALSSPNFAILEMSLGMHYNTEAGDIDLLTYLKNPSVFDLEGGHVKAPTGYGLGIEIDEEMVIRIAKETEPWQCKTFHGPDGSIREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGM4</accession>
    <name>S0EGM4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_09373</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435883.1">
        <property type="nucleotide sequence ID" value="XM_023568732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGM4"/>
    <dbReference type="STRING" id="1279085.S0EGM4"/>
    <dbReference type="GeneID" id="35402842"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09373"/>
    <dbReference type="HOGENOM" id="CLU_031730_4_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495992" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="21"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="244"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="266"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT73805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="357" mass="36776" checksum="4398EA5DF60A5024" modified="2013-09-18" version="1">MRSSFSTALALVAALPTAFAHYNFDALIVNGKVTEPYEYVRKTTNNNSPITDVTSKDIICNAGGLDKDIRAATKTHAVSPGDEVGFTVANDMGHPGPLAVYLSKAPDGTEASDYLGDGDWFKVYEMTWKTIGENGIEWANYMNGQSNGITNFTFTLPKETPKGTYLMRAEHVGLHGAGEKNGAQFYIGCAQLTVDGTGAGKPSPVVSLPGAYTATDPGLLLSIYYPPVTNYTAPGPKVWPSGCEDHTPNFAGQASDGDCTNDKGSDSGSGSGSAAPVASDAPATEAPAASSPATDAPAASAPATTEAASAATPTEAPIEQPAETSAPVATKAPSTGGKCKAKRAAKRALKAKRALKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHT7</accession>
    <name>S0EHT7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to tol protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436432.1">
        <property type="nucleotide sequence ID" value="XM_023569181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHT7"/>
    <dbReference type="STRING" id="1279085.S0EHT7"/>
    <dbReference type="GeneID" id="35403867"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10402"/>
    <dbReference type="HOGENOM" id="CLU_002639_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="221"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="749" mass="85240" checksum="9B9F536E78FD1C2E" modified="2013-09-18" version="1">MSSKICTPCRQAFASEPRPLDRDSTIAGTPFHEAPWKAFQTGADISESVKGCDFCSFVVAFAAADQALGRHGNGSFADSAGKTSWRTQGDPMLALWQYNEYTYEGHLSADLGLSRSNLRHMDRLDIRLFGTEDPRVKCHRPIKKTSTSTSSETSFECLCKWIKNCSENHKSCNKLHARTGENKNWLPARLVKIIPDTDSVPEIIKVVETNTDDGIHQSIEYATLSYCWGREPFTKLLRSNIEKMTTTGMSIQDLPATFRDAITVANRLGMEYIWIDALCIIQLDAEDWGLHSVTMAKVYSYSAITLAAAASSDAHGGLFRQRNPAGINGVKLNLKWSSQDLEGEFHLVPTDPWEKAVGNSPLLKRAWVFQERLLSRGAVYFAHDMLCWECGELYASELYPTGGPWDLQYRYKRFDISDRLPPGVQSVEDYRFKHVYTELLTRELNAEKTVTDEEMFLYVWASVVTQYSVGKLSKESDKLIAIDGVAEQLTTIVPREQYLNGLWRKDSLPLSLLWCTQTEDEPPSIRVAPSWSWASVYTPVDFNFLFRAQTEPKVVTKVIDIIIPDDEPESIEMSRPTALILQGPLTEVRFRSASRSALGPLHSNWWMSHKTMEDRIKFLNPIDLAPMLVFIGKGLKADYPCAISLDREVPKNSRMFALKIAEADIRHPWQQRLPSECGLLLIADRERGTFRRIGMFEIAAEKMKRDWADQKTPFTSISKLREEIWRDSGIERRFYLERDEKDGYTIKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHZ3</accession>
    <name>S0EHZ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to transcriptional activator Mut3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_10669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436689.1">
        <property type="nucleotide sequence ID" value="XM_023569479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHZ3"/>
    <dbReference type="STRING" id="1279085.S0EHZ3"/>
    <dbReference type="GeneID" id="35404133"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10669"/>
    <dbReference type="HOGENOM" id="CLU_011099_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT74611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="607" mass="68386" checksum="AE8C935BB0E8848B" modified="2013-09-18" version="1">MRVASHARRRKACDLCVSRKIKCDLAKPTCSNCKLYGVDCSITEVKSPATTSRRKAPASETSPADLSSTLHRNDTIESRLTHIEARLDQIAAEKPSGSASHNATTLNFQNFPEIRVYKASDMWNEATTLPCLGISPQFPTGAILAQTGKLELPPLQEVMGVLERYFDSYGCYMPLFDKGSFMKMTVDWYSENERKDLIPWAAINLVLAMTYRIMDDVPIEQPKLAQCMSNVQSVTTELMAWSDDILGLQVLLGMIILFQGTTNPQLAIVLIGSAIRLAQSMGLPSARASDDPDGSAQRGRVFWIAYILDRDLALRAKAPYTQFDAETDLELPGQFGDDDMGILESCTGTIRFNYLRARSELAIIQGKVHNFLYSRTAQRLSQEQRAETKVRIEQMLSNWRSALPQELLRSDKLFQDFSTISVHLVMNMYNRYLECLYRIHGTFAFDETWTDRALCYLSPTVIPTGDDGIDGKINQKEISPMPSAWSDCVEHSRLGLELAAFGRETEYSTWLHACCNLSGLIVLLVNIIEFPDQPSVMSDWSLIVRILSKFDQMNDKASNEPFFLLQVAHELDRKASRQVKRVAHMPSLSHQEAAFSEPWANPDLMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIQ9</accession>
    <name>S0EIQ9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to ThiJ/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436737.1">
        <property type="nucleotide sequence ID" value="XM_023569535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIQ9"/>
    <dbReference type="STRING" id="1279085.S0EIQ9"/>
    <dbReference type="GeneID" id="35404183"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10719"/>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="210" mass="23155" checksum="67D1BB0AFCBDC111" modified="2013-09-18" version="1">MPPPTKYAVALFPGFQALDVFGPLDVLNFTSKRQPLQLSLLHTDLNPVSTLEDDSPGRIGQSVVPTHTYDNAPEDIEVLLVPGGRGSRNPENVKRVREFVKERYPKLKFLLTVCTGSAIVAQSGLLDGKEATSNKRSFDWVETQGPNVKWVRKARWVVDGNIWTSSGISAGIDMIYAFIAEQYGQEIADDTADGSEYVRNTDPKSDPFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIR8</accession>
    <name>S0EIR8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to 3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_12129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434356.1">
        <property type="nucleotide sequence ID" value="XM_023581699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIR8"/>
    <dbReference type="STRING" id="1279085.S0EIR8"/>
    <dbReference type="GeneID" id="35405585"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12129"/>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="188"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT72278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="287" mass="31779" checksum="9DC4DFD59470A4A9" modified="2013-09-18" version="1">MVLTSASRTSVTLIGAGTQGRRLAFMWSSRGNDVHLVDGQEAQLQASIKAIEEFRQSASNRNASWGKIITHSPESLREALQAAWLVVECVPEQIELKTKVISELDALAPRDTIIASNSSSYSCSEILKGLNLRNETRFLSAHSYWPPETPEIEIMGHETTNPSYITLMMEQCKAHGFSPFHVKSPSMGYIYNRIWAAIKREALLAASEGAATPEEIDNIFKGVLKTPKGPFEQMDVVGLDVVLDIEQHYADARGNIPSAPREYLQKFLEEGNLGVKSGRGFYDYGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ17</accession>
    <name>S0EJ17_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436683.1">
        <property type="nucleotide sequence ID" value="XM_023569471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ17"/>
    <dbReference type="STRING" id="1279085.S0EJ17"/>
    <dbReference type="GeneID" id="35404126"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10662"/>
    <dbReference type="HOGENOM" id="CLU_035734_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="51"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="442" mass="49210" checksum="9418CF78B78AC0EC" modified="2013-09-18" version="1">MTVDLEQQSSSPAPTLHDEPAVMEDTQRHGINSTTWHGRRGLVVKILTGVMVAILVVFLADLSYVFGSTFEVGNRVSGLKILVVDYDGGAVGESVASAYKNFQDKTFPTLEFRSADDYPETKDVKHGVCHADYWGAIYINKGSSDKLAAAYEGGSAAENYNPADSITYIYNSARYPTVASGYLVPNLQKIIGAARGTYYQSQQGRSALRSVNSSDPAAVEAFLNPIQGTADIIMPTNQGSRNLYNTINIVMAILGQFFYVLAMNGIYDKFGLHKNMRIRDLFIMRLINGMVFCALFALIVTGYIWAFREDWDVSGGQFALSWLTFWLFMDVNFQVLETLIGSFIPMALTPFFLLTWFMMNVGSVVFPFELTAGFYRIGYIFPAHSLWIILIQVWSGCGNSLHIGLPILFAWFVVGHVTAFFGIRKRCLDQLENLKTAEGKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJG0</accession>
    <name>S0EJG0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein CAP22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434586.1">
        <property type="nucleotide sequence ID" value="XM_023581985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJG0"/>
    <dbReference type="STRING" id="1279085.S0EJG0"/>
    <dbReference type="GeneID" id="35405841"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12385"/>
    <dbReference type="HOGENOM" id="CLU_093536_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485980" description="Protein CAP22" evidence="2">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="22921" checksum="D1776CBB57C9E178" modified="2013-09-18" version="1">MYTSTIALAIAPLLYLARADISLDRDDIPRECDTICDPIVQLTKTCDTDLRGDRDREEDRLEAQCVCTNDSFNVSRVAALCAGCIHQNAQNNRDNDDDDDDIRDDTEEIDDLMYTCGFSSTTYVASAASAAVSGVSVDATRPTDASQLTTTIVGGTRTQNSNEPSATGSSGGNGGSGSNDDNNDASATNDASNPDETNAAAAMAPYGVVGAVVGAAMLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJJ4</accession>
    <name>S0EJJ4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437037.1">
        <property type="nucleotide sequence ID" value="XM_023569884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJJ4"/>
    <dbReference type="STRING" id="1279085.S0EJJ4"/>
    <dbReference type="GeneID" id="35404497"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11033"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="270" mass="28168" checksum="C32E95DEAE95E35E" modified="2013-09-18" version="1">MDVPGYAIIVGGGSGIGRACAISFAKEGASGVLIADINVRPAKDAVSECKAAAVNKEFRCEAIHVDVTREDSVQNLMSHAVQTFGRIDYCVNSAGIGVRQAVDIANTSLSDFERFLRVNTTGMFLVTREASITMRSQEPVATSAGRGVSRGAIVNIGSASSMVASPGVLPYTTSKHAALGLTKNSALDNASHGIRVNCVCPSWTDTPMTRQALEGVQGLVEFVHAAVPMGRIATPEEVADAVIFLCSSRSSYITGTALIVDGGTTLTAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJY6</accession>
    <name>S0EJY6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437389.1">
        <property type="nucleotide sequence ID" value="XM_023570250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJY6"/>
    <dbReference type="STRING" id="1279085.S0EJY6"/>
    <dbReference type="GeneID" id="35404823"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11361"/>
    <dbReference type="HOGENOM" id="CLU_053883_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="515" mass="57464" checksum="9D6601076EEA1CC4" modified="2013-09-18" version="1">MEPSQRRRAGCTECKRKKAKCDEKRPSCSRCYKYPHLCSYELSVKTFRVAKRKPASNAQIKTQPLFTDVTAGGQQVSLAPSSAVTSNQLISYTDTSDTFDSSFLSSSMLDDSSDFLISFPAVSPPRLSVSISLPSSPPLRSDPRRIYFQHFVAHTAIVYWPLQPDMALNLIIPAADFSPCIMGAMIAASSSQLFRMARNPESKSAAISATVECLGNLREAITTPGFGNLGVTILPTTLMLATTCVCAGDTTTFRKHLNGALHIVQRDKSKYSLDPLWWMSLKWLVHLLLMNRLSGLPLPSRQTKGFIDWDYLLTCMPDLGRIDLTSGFSRELVTALNMVCELSEPRCTDVEASSQLYGNDLARSAYSHELELRLIELRKKTASTIADVVLRTELESSHRLFTDATLLCLYRRVDELPKDNPKVQATVNSIINSLHSIDKHSPVHAQLLWPLLAAGCDSIIYAERTIVVETMESMTARGMGSYENVLEFMRDYWKNGGDMRWDLFAKQTGKDLVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJZ3</accession>
    <name>S0EJZ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to NPP1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Necrosis inducing protein (NPP1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436270.1">
        <property type="nucleotide sequence ID" value="XM_023568994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJZ3"/>
    <dbReference type="STRING" id="1279085.S0EJZ3"/>
    <dbReference type="GeneID" id="35403700"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10235"/>
    <dbReference type="HOGENOM" id="CLU_062263_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496130" evidence="3">
        <location>
            <begin position="25"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="253" mass="27240" checksum="21F4808C640B2826" modified="2013-09-18" version="1">MHPQTILNALVALAATGMAAPSEALNNIHARAVVNHDSLNPVKKTIEGGAIGAAIDRWQPLLHIADGCQPYTAVDTNGNVNGGLQDSGSKTGGCKDTSKGQTYARAAMHNGKLAIMYAWYWPKDQPADGNLVSGHRHDWENVVVFIDNYQSPGATLYAAAASGHGDYKKTKNPQRSGNNVMAEYFTSFGKNHELQFKTSPGRTYWIYDWAAMTPAARQGLITGPSGDPKKPWGSANVPFIDANFGNNLNKAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK10</accession>
    <name>S0EK10_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to mitochondrial Fe2+ transporter MMT1 and related transporters (Cation diffusion facilitator superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_11188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437182.1">
        <property type="nucleotide sequence ID" value="XM_023570058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK10"/>
    <dbReference type="STRING" id="1279085.S0EK10"/>
    <dbReference type="GeneID" id="35404652"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11188"/>
    <dbReference type="HOGENOM" id="CLU_013430_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="108"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="308"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="394" mass="44127" checksum="3DE4622A1833455E" modified="2013-09-18" version="1">MSNQTDKIAMSSVHTRAHVQGKDVEVQHDIDDPLGLSAHIKLESDMPRANTSRKRHLGLKKNHPLQEFYETQNQSIRAMLKSVEEHEQEVTDAHGANTLMYGICVKGSLVANIILSGLQLYGAISSSSLSLFTTMADSVFDPMSGIMLYMAHRAVNKVDPTKYPSGRARISTAGNIVFSFIMFSVSLVLIVMSARDLAAGSEEETNKFHLPSVIAVTVAFATKLGLFFLCWTVKDIYSQVDILWRDHRNDLFINGFGILTSVGGSKLKWWIDPMGAIILSVLIAGLWLHTAYDEFQLMIGVTADKDLLQLITYISMTHSPLIQQVDTVRAYYSGPRLVAEVDIVIDRNERVEVAHDVAEDLQIKLEKLPVIERAFVHIDYETSHKPEHYLKKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK89</accession>
    <name>S0EK89_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437292.1">
        <property type="nucleotide sequence ID" value="XM_023570136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK89"/>
    <dbReference type="STRING" id="1279085.S0EK89"/>
    <dbReference type="GeneID" id="35404721"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11259"/>
    <dbReference type="HOGENOM" id="CLU_041815_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="446" mass="49597" checksum="28AF37DE1159A7CB" modified="2013-09-18" version="1">MGVSAPHPSQRRFSCDVCRKSKSRCQRIKPTDEKCARCSMLGVKCEIGQQKVPGRPRRKQAGKGSPPAVQHLPVSKPVSPNALSQNATLMDDWSPFDWTGMLSPKPSPPQMPATAIQDGIATSWGIGFTDIFDQSQTSWNLGGDLEYTNTPLCTDLDTITNLYPVSISPDSTITYETFFPLTNCLTTHQPRKEDPGAFMADLSTINLGLHIRLEAMKKTKPSLDFDLMIYQHGPLFIDGITLAEYIIKVAQEFLYILTKLYNTRHCPELLCDSQPMELICPCHLSSELREKSRNLFDVSLPRPTVTSEPLPTPIALMITSIFIQLITIYELILDNIATRVERIATDPIEPVPGLIVCGRPLERPCTQGMIFCEVSVSLIENIERVLGVGRGLDGKEVGLLSLRQVDVLGKELDERPRVIPDHAMMTPAMLRKLLGKVADIFRSIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELK5</accession>
    <name>S0ELK5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_11516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437538.1">
        <property type="nucleotide sequence ID" value="XM_023570424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELK5"/>
    <dbReference type="STRING" id="1279085.S0ELK5"/>
    <dbReference type="GeneID" id="35404978"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11516"/>
    <dbReference type="HOGENOM" id="CLU_024655_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT75492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="413" mass="47148" checksum="34165A00056EEDAD" modified="2013-09-18" version="1">MSRIGLTRYEVKACKACQSSKRKCTKQQPKCRRCDLRGLDCLYEPLPNTFVYQATQNCGGQASPLADLPEPQLLQSGQDDSWSELVDIGVDSHMNHQSTPGTISLEDLKLAWFLVPESWRVVPVRESNRAHLTTDMIRGLLYQTRDWLEDWTKSGSNVFVHHEIYKNSLPDCISDAFTVLYSYFSRTPETSEMVLRIAEQKAERLLVSEGNRNTAGDILSSLSRVQALLVYCTIRLLDGDLRQRHKAEQHLRTLQDWTKEMMNNALEATNNGDMIVKNHLTNVSPQYFTLPLLLGQFSPEQLLWHSWVLSESVRRTWCVSMGLQSGYELLKTESGPCYGTLPITTRKGLWEARSAFAWTKMCAESNIGFMCRNDHEKVMLNMEPADIDDFASCMMELDVGPDRMARWKSERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM16</accession>
    <name>S0EM16_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyranose 2-oxidase</fullName>
            <ecNumber evidence="5">1.1.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">FAD-oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucose 2-oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Pyranose:oxygen 2-oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_11715</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose + O2 = 2-dehydro-D-glucose + H2O2</text>
            <dbReference type="Rhea" id="RHEA:10552"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16609"/>
            <dbReference type="EC" id="1.1.3.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.10" evidence="5"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438114.1">
        <property type="nucleotide sequence ID" value="XM_023570646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM16"/>
    <dbReference type="STRING" id="1279085.S0EM16"/>
    <dbReference type="GeneID" id="35405176"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11715"/>
    <dbReference type="HOGENOM" id="CLU_023699_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050233">
        <property type="term" value="F:pyranose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012814">
        <property type="entry name" value="P2OX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051473">
        <property type="entry name" value="P2Ox-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02462">
        <property type="entry name" value="pyranose_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784:SF1">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="14">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="13">
        <location>
            <begin position="273"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="15">
        <location>
            <begin position="410"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT76068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="545" mass="60735" checksum="A96F7B3BD6D9A1DF" modified="2013-09-18" version="1">MVHKPTPSPSSASDTFHLEKTDVLIVGSGPIGATFAHTLVKKGIKVTMIDIGQQETRRVGDHKKNSVAVQKDISLFTNTVKGELHPLSVPTNSARPVIEPASWSRRPTDSAYVLNGQNPEQKAYGNLPAAAATRVVGGMGSHWTCCTPRQHKGIERSDLFSDSEWNALYSRAEKLFKKTDDAFDDSVRQRLVKRVLTEAYPDREMKSMPLACKRKQGNKEYVEWSCTATILGELSTPEYFYKGEERLFDIRPNTQCDRLEVDALGQIHYAVINDLENNKEYYIEAKKYVVCAGAVLTPGILYKSKLKGKLPMLGHYLTEQPMAFCQVVLDRTLVNSVRDEEAVKTHTAAHENDPLPFPFNDPDPQVYFPVSEKYPWHTQIHRDAFGYGEVPSNIDQRLVVDLRWFGYMKPEYENCVTFSTETKDQFGMPQPIFNFILDEEAEERCKRMITDMIDVARKLGGFLPGAEPKYLAPGSALHICGTYRAGSTSADSVVNKNGKAWGVDNLVLGGCGVIPTQNACNPTLTAACFALAAADKIIEDLQVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM92</accession>
    <name>S0EM92_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_11082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437085.1">
        <property type="nucleotide sequence ID" value="XM_023569939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM92"/>
    <dbReference type="STRING" id="1279085.S0EM92"/>
    <dbReference type="GeneID" id="35404546"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11082"/>
    <dbReference type="HOGENOM" id="CLU_008198_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clr5" evidence="4">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1078"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1113"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT75007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1277" mass="143331" checksum="323360ABF92C4F4C" modified="2013-09-18" version="1">MSTAKPQTKKGQWLQHKDFIRYEYLVRNTSLTDLLVLLAGRGLATTKAQLEYRLKLWRFSKNLDQEIWRSVGRKIKRRSDVGKKSEVIYDGNRIKHSKVTKETARHSESFYHGLALRPRSPSPINPRLVVCSPLPIKQDTIWPLSIPWLMLRDVLSDNTTSFVSPSAIGVYRSTDSYALLSTIVQALRQSRTNRPYWSFQELAVSIGASMPEWYLGESTHTASILLGNQANEILPEYIKFVIYALSNGTRSFDRAQWDIFSSILRENMSDLQPKLRQLQSHSITIRAFLEKVFQMEIYWATHIDGPANRRKDYLPDRSLDIIQMLLESGLDPNYRLTGHNGPLVTPIGRALNIGHIDLSELLLSFNVRIDNTQADFDGYTAIQAILRGRLSNAVQSRLLNLLKEYKAVSLEEVLCGALRLDDMELIEGILQENIDVTKVHFEARLLQSYELGDKSNILSYESPLTTSLGGNCHWTEKLLNHHSVQKAPSEVLTGEIFIAAAIRGHCQIIGQLQELSPTGLARKWNGITCMRAAVAYDNVPVAQLLLERSHCTSPDLLLIAAHYGYEDMVKLLLQYVLSPDEMVSEGDVKWLHYFTAGPPMPKNCGSILQTLLRSHFTPWNASKANCLVLLIERGVRFLGGEIARLAEIGFREPLRAALARGGSPNDRDKYGRTAIQCALYPKGYLRISRSRHANTSCEVNKRYRTIRLLLEAGAEQSGEIVNAIRESDYNVTKLLLEHGGTLEDINERGASCLEALIMNSNNISFMGANSHYFHDHYPSLNEGTMRGYHSARFGVQDNTTIACSTCAARCFDGSDERDFLQALLEAQDDPIDAGPICAAIQVEDWELLDRLITRRHKETNCHLLEGTAIGLAARAGQMEILEKLLTRFHHPSAVQSGFIPFYVEEGQLVLRPSDDSSLKFNGRPWVYDTNDFWRKDPVLGLRGVASPLALAALGADPSGSEALLAHGCCADKTTFTVIAQKESAFVYLGLLRKHSQQLDTPFPSQSTLCSILLGPIENGNVELLEGLVDAGSDVNDHNATLDSSRSPLQLSAQLGDLGMVHYLIEKQADVNSPPSFSRGGTALQFAAIGGYMGIASLLIDHGARINARGSRKDGRTALEGAAEHGRLDMLELLLQRGAAWSNYGRQQFISAVRLALQNAHYAAVHWLKNRYGWTEEDEDFQEDGVDYWFRWDERCKNCRDFCCDEIHGTEDNCIHYYSDDTEEKWAAECYYCKLKAVEDDGSQSEGEEVLYQGPGQKLDDYDIFFEPWVSDYSLLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMJ6</accession>
    <name>S0EMJ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2264 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437185.1">
        <property type="nucleotide sequence ID" value="XM_023570062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMJ6"/>
    <dbReference type="GeneID" id="35404656"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11192"/>
    <dbReference type="HOGENOM" id="CLU_028269_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF2">
        <property type="entry name" value="DUF2264 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20938">
        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="1">
        <location>
            <begin position="14"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="384"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="81313" checksum="20633965472ADC14" modified="2013-09-18" version="1">MPGLPGFSDNPFRDRHDLIRAATAIIKPLGQYRSKSNARVKLFPSTAAAFDDVAAQLEGFARPLWAISSLVDKSTDPSLRSWLRGIEAGVDPENPEYWGHLGSFDQRMVEMESIAFALLTEPHVILSFLNPESTKNLEKWLQQINKFDMPRNNWRWFRVLVNLALMKVLGSDKEKARQAMDADFELLDQFYLGEGWSSDGAWGEDRKQADYYSGSFAMQFAQLLYVHFAVDDVKRVAKYRQQAIEFASEYWRYFDTNGAAIPFGRSMTYRFACGAFWSALALSEVQSSEPRLSLGTIKGLLLRHLRWWAKHPEIFNSDGTMNIGYAYPNMYISEDYNSRQSVYWCLKSFVVLGLPSDHPFWTVQEEPHPIYGLIPSARHPDNARTFPAPHQIVCHSEEHHYLLSAGQMTTKMFKAREAKYGKFAYSSAFGYSVPTGMELHQIAPDSTLTVKLDEDGPWRVRSQPVDVRFDTILIHSAKGRGHLPSTTSTWRPVESVDIAIQTTLIPLTYHYPGWHLRIHRIRGLGAVNGIPWFNCFEMVDSSFAVDALTDAGYHIPANDTSKIKHHGQFAEGYVTEQASVLVKSRRGVSGIVDLTPSIHLKGGLARDQAKLGRRGYLIQADPNTNLVSQKTLIPSIRYSGAGAAGNQSNMPVASEAPLSAFVVTAVFGVSNVNQSMEHVPNDWYYLQDDWAYKNMLEIDVTAAGETHISIQQVTPRGASGRGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN16</accession>
    <name>S0EN16_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to 2-deoxy-D-gluconate 3-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435921.1">
        <property type="nucleotide sequence ID" value="XM_023568778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN16"/>
    <dbReference type="STRING" id="1279085.S0EN16"/>
    <dbReference type="GeneID" id="35402801"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09332"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000398">
        <property type="entry name" value="Probable 2-deoxy-D-gluconate 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="261" mass="28034" checksum="4AA7B442DF246132" modified="2013-09-18" version="1">MSILESLFSLKGCEAVVTGGTRGIGQAMALSLAEAGADIILVQRDERNTETKALIEKLGRQAFVYTADLSNQEQVENLSKRILADGHDVSILITCAGIQRRHPAHQFPMSDWDEVLQVNLRTVWTLCRDLGSYMLTRKPDASGHRGSIINVASLVSFQGGLTVPAYAAAKGGIAQLTKALSNEWASQGVNVNAVAPGYVATDMNEALINDEKRAESILSRIPAGRWGCPEDFKGVTVFLAGRGSLYVSGELVTVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP03</accession>
    <name>S0EP03_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438090.1">
        <property type="nucleotide sequence ID" value="XM_023571087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP03"/>
    <dbReference type="STRING" id="1279085.S0EP03"/>
    <dbReference type="GeneID" id="35405570"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12110"/>
    <dbReference type="HOGENOM" id="CLU_021598_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="529" mass="60718" checksum="8C81D572AD1EE276" modified="2013-09-18" version="1">MASPTPFILPTLPEEVREAIYAHLESGDVKNLRATCSAMAKLIPLSFDRVYISANSTNLKVFRAIADDETIRHQVTEIVWDDARLTAGPELEEDRMEYEEDGVDPDDVVTNNGCPLWFEKGRSDYRNDGSYILPDYLMGIEESWAYYKGLLEDQRQVLASNADIKAFKYGLQRFPSLKRVTITPSTHGRIRNPLYRTPMIRAFPRGFDYPLPKAWPWYTNELSSPVDVLPWVSDDSSPHQEMYGPDCTVENYRAKWRGYRVVTRALVEHDDHSITELSIGGHEIGSGLNCRIFDQRCVEYDDLVTLLKRPGFRYLSLDLFTGVLEREDWESYKSGLLHDALAQAKDLEHMCLRSTMGITGGSSEQLDWKDIEKYAFPLRTIFPVDQWPRLRHFGISNMLVQHDDLIELLSALPRTLRSVELRYLAWGSLDHGTRELLPSMRDVLDWRSRPVEERPTVHMIVSGMPYGQGDARGWYVEIDELVQSVLYGEGGNPFVEHPDIIYPGQGGVKRDIFNPTFKVPHVDKNLWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPE7</accession>
    <name>S0EPE7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437066.1">
        <property type="nucleotide sequence ID" value="XM_023569916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPE7"/>
    <dbReference type="STRING" id="1279085.S0EPE7"/>
    <dbReference type="GeneID" id="35404525"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11061"/>
    <dbReference type="HOGENOM" id="CLU_434023_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="680" mass="75457" checksum="090ECEBAAC43883E" modified="2013-09-18" version="1">MVSFNILRALTCFNSAQRILHPSTPSQPVTLKLTGDPCIQVDGVWQITEDCIDPLYSRPVIDSETHVTLTIPHLRVSGHFEGTFVDFNIYLPKNGWKGRFFQLVYPLQNSSASDREIGFGAESGGYTVRASGLPTYRGDAAAAKFGMMIAREHYKPKNNKIHGYVYGGSGGSLITVGAMENTIGIWSGAVTLVQAVPVSINNWSVRALAGLVLQTKSAEIEEVLRRGGSGDVYSTFSHTERKVFEEATALGVPIKGWETFYETGASESLWESIRSVSGSAVMRMDPTYVEDFWNKPGYLGTEKSKLGDMFREEMLDYETLITSIKYDVNNVPVELTFGEAPKSTRTYWLDIIIMSKDGEEIGKITAKGQDNRDNNTVTLHPNNDTAALSLLQKGTQVHISNRMFLAMHALHRYSVPKRAGFYGYDYLRDSMRTPIYPQRSALVAEQIARSGSGGATFSGKFNGKMIAMDNLMDVDALPWHADWYKNQVKKAYGDEFDNKFRLHYTENADHQMGLVVDSKSSRIVDFTGMYEQHLRDLSVWCETGTYPSTSTNYTISNSQVRLPAMALERKGIQPVVSLSVNGSKQVEVKTGTTVTFRVHAEVPPGAGKITSLQCDFEGTGNFVKKSFREVRQSAGTMVSYTYYRQGTFFPAVRAASQKKGNIDSPYGLALNLGRMKVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ05</accession>
    <name>S0EQ05_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_11433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438106.1">
        <property type="nucleotide sequence ID" value="XM_023570332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ05"/>
    <dbReference type="STRING" id="1279085.S0EQ05"/>
    <dbReference type="GeneID" id="35404895"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11433"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT76060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="427" mass="47427" checksum="6F3E402AEE008B7D" modified="2013-09-18" version="1">MDVKKQRIVIAGGGLGGLTAACRLARDGHEVDLFERSPSLSTASGAIFVRSNGVRCFYRWQMREAFEAVTARIKVHETRNGNTNELLHTLNPGIYSKFPEWSTDRQALQTVIYDEACKAGAKVHFGNEIITVEEDDQAAYATCKDGSRVTADLILAADGISSRLRSQVLSHVDPSRLTVIRAPSTHYPTEIPAEMLANDERTKSLCQQPESENGIMWAGHGGYAIGKYNHHRGLFNIMFSIQHGAADSEASEKRLFDATDDSEVVKSFFSSFNPTVVALANMVQSCSRWRLARLEPLDTWSSPKRRLVLLGDSAHAMLPNLAEGFSSIVEDIDALSILFSESSRDVPTTIETWEKIRIPRVTRLQNGSTWNYKLYNSGKPPGSELTDEQRALLMGEGDGNAPFNTLPFDKWMFDYDTAKEVRVAMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHY8</accession>
    <name>S0DHY8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_01847</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423756.1">
        <property type="nucleotide sequence ID" value="XM_023574173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHY8"/>
    <dbReference type="STRING" id="1279085.S0DHY8"/>
    <dbReference type="GeneID" id="35395330"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01847"/>
    <dbReference type="HOGENOM" id="CLU_057784_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045015">
        <property type="term" value="F:HDEL sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT61675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="215" mass="24981" checksum="63FC7352CBDADD82" modified="2013-09-18" version="1">MPLNVFRVAADFSHLGSIFILLHKMVQLNSCSGISFKSQTLYMLVYITRYLDLFKTDSIYNFIFKIMFLGSQGYIIYLMTNAYKPTNDPNVDTFRVQYLLAGAAVLAIVFPYHYTISEILWAFSIWLESVAILPQLFMLQRTGEAETITTHYLFALGSYRALYIPNWIYRYFAETNHKVDTIAIVAGIVQTVLYSDFFYIYYTKVMKGKKFKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI17</accession>
    <name>S0DI17_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423811.1">
        <property type="nucleotide sequence ID" value="XM_023574840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI17"/>
    <dbReference type="STRING" id="1279085.S0DI17"/>
    <dbReference type="GeneID" id="35395270"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01786"/>
    <dbReference type="HOGENOM" id="CLU_044378_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="65"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="384" mass="44363" checksum="72F12A035DB28917" modified="2013-09-18" version="1">MISVRALDHFREQFCGEAVPISDDNNNTKAPSTSGDEEDVQKKTAPQLFHELAKGDNSLIAFNTENELLRLPAELQLMILQHLTFGEVESLRRTCRLLRYTINKPFIREVFPSIKFELLSTCFRCLRYDAMRDHLIHADESDARYPLANECLDCVSSRGGFVVGRIYTLGTFATVCVCRYCGFPVTSDAAWKEYEFHRVCYRRYRMILLYYFLVGCAQSTITIAAASLCWKYYKKDKLVLGPTVVNFLMACWVFCLSMVRGTEMRTYHWSLLLEMSIFGLWIPPLTGVVRTMGIRSEGVRAADIATIFFIACNMIFRFINVLGNTLLVSEYKLWRRYMPNQSRPARILNKVIAFLIFWTYPPSIEQKFPGKWWFSRQNTQAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIM9</accession>
    <name>S0DIM9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to anthranilate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_01120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424420.1">
        <property type="nucleotide sequence ID" value="XM_023582272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIM9"/>
    <dbReference type="STRING" id="1279085.S0DIM9"/>
    <dbReference type="GeneID" id="35394605"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01120"/>
    <dbReference type="HOGENOM" id="CLU_034315_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000010">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="3">
        <location>
            <begin position="109"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="411" mass="44620" checksum="9FE612FA84F692EA" modified="2013-09-18" version="1">MASQSQDGGQNALSPVDIKPLLTKLWPNGSAVSPQEIAEAISHFFTNQVTEAQTASLLMALHFTKLDFRADVLAECARVMRKAAASIPVEELKEVIERRGRKEGDYNGGLCDIVGTGGDGHDTFNISTTSSILASALLMVSKHGNKASTSKSGSADLVACMKPQPPIISAVRPDTLVKAYSETNYTFLFAPVFHTGMRYVAPIRKQLPWRTVFNNLGPLANPVEDVLEARVIGVGRRDLGPAFAEALCMAGFKKALIICGEEELDEVSCAGNTLCWRVNETSTGRLEVEHFTVHPSDFGLSTHPLDTVSSGKEPSENAEILSRILHNELPDDDPILEFVLLNTAALLVTSGICESDTSNMGEGDDGKVITERGPGGQRWKEGIRRARWALKSGEAWRQWEKFVKVTNEIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJP0</accession>
    <name>S0DJP0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centromere protein H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424626.1">
        <property type="nucleotide sequence ID" value="XM_023569962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJP0"/>
    <dbReference type="STRING" id="1279085.S0DJP0"/>
    <dbReference type="GeneID" id="35394381"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00896"/>
    <dbReference type="HOGENOM" id="CLU_078299_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040034">
        <property type="entry name" value="CENP-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT62545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="232" mass="26135" checksum="285731C4358328DD" modified="2013-09-18" version="1">MADSKDVSMMDVQKEMPHLPISEDEAKILELYDRIQELRLEIAIINAQKSHQPDETSSFTAEETEKAQSELMESRAQYILRNEVTEAVMTANPILRAVHGGPEAALIERELLPYIERRDDTSISVATQAAETNKVLSVLTNVQSNTLRKSRENVTSAAEMLELAEQVKLKKRVPPNSKMIQEQEELEADVKASKQRWRVMKGVASGIIVGSGIDWVHDDELQDVVLDPEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJQ3</accession>
    <name>S0DJQ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424880.1">
        <property type="nucleotide sequence ID" value="XM_023573098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJQ3"/>
    <dbReference type="GeneID" id="35394098"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00613"/>
    <dbReference type="HOGENOM" id="CLU_062870_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="222" mass="24631" checksum="5C7856C06E53E031" modified="2013-09-18" version="1">MAIANVEKTIFTAPPSLPIPQQKPSLGDLRLPTLTPDAPNIRTHISRVFPSEPKDYASGVATWVLLDKLNQGQRYEFRICWAAIQPTVFNLAVYELDTVWQTPELIQSLANYSFSRQDQEAVLTKESTQTEGREREASVLLLQIKSSADYFTNDAALMKDPSPVHVDLILDPYLYGIVPRSLVPAAGYLVLVGAVAWFVSRSIASRLQTITVTTDGANKKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJW1</accession>
    <name>S0DJW1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423658.1">
        <property type="nucleotide sequence ID" value="XM_023573140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJW1"/>
    <dbReference type="STRING" id="1279085.S0DJW1"/>
    <dbReference type="GeneID" id="35395421"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01938"/>
    <dbReference type="HOGENOM" id="CLU_037536_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="461" mass="52063" checksum="48848BD18C687D08" modified="2013-09-18" version="1">MPERSLKLDSAANTFLGEPFELKPLVSEILRTKYCIPGSIFLVEGVDRISVSRSGRWQVIRFILGDGEVCIQAILAPDMHRFVTTGDISLGAYVRCEKFDVKWKDIGEESMVMLLVKDLITIGWNEAYRALQKKDEPLPEQIPAPALQAKSVPQSKPAPEPEPEVRLAPDQPELPKGPSKPVFEDYMEFDDVDEAAAEEAFEAFERLMDANRPQTAQKPPPLRKIESPRKTAALPKPQTPTKGTLWQKPRTPQKTETLQKPKTPQKAEQSLKPQTPQKVQALQKPNTPQKTEVSRRPQTPQRTAITQDTPTSHQAIALPRDWHDPQTPLKLTTLRQIPHLPYAQNWSCNVLAIVSHLSAVEPSSLPPYRQRIARLADPSTSKQVHLTVFLDPEAFTPRVGSAVLLVGVKNHRFDGGSLKKYESDRKNGRWWFENPIEMDWCDVEGINDWWVQVTAATQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKM5</accession>
    <name>S0DKM5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_00449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425027.1">
        <property type="nucleotide sequence ID" value="XM_023573281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKM5"/>
    <dbReference type="STRING" id="1279085.S0DKM5"/>
    <dbReference type="GeneID" id="35393934"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00449"/>
    <dbReference type="HOGENOM" id="CLU_006421_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14096">
        <property type="entry name" value="STKc_RCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="102"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="230"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT62946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="575" mass="65194" checksum="600F77EBDBD2910C" modified="2013-09-18" version="1">MSTIQQLKNFIRHGKQARAAAPEEAPRKTEQQQAPTVQHKTASDPSNTHYARAQEPGNEYGDDDYSRSKSKKRIDDEKLAKLIAEENASKSKFPRYPGLERWELVDKMGDGAFSNVYRARDTTGQQGEVAIKVVRKYEMNSMQRSNILKEVQIMRQLDHPNIIKLVEFSESRQYYYIILELAPGGELFHQIVRLTYFSEELSRHVIVQVAKALEYLHEEKGVVHRDIKPENILFEPIPVVPSKHPKPKQPGDEDKVDEGEFIPGQGAGGIGRIKIADFGLSKIVWDNQTMTPCGTVGYTAPEIVKDERYSKSVDMWALGCVLYTLLCGFPPFYDESIEVLTEKVAKGQYTFLSPWWDEISKSAQDLISHLLTVDPEKRFTITEFLAHPWIAGNGPTPREEMKKSDGMLRAFDATKFEESGKRYDFRSPGAVNLREVFDVGYAVHRQEEEGKRRAQIGPKGTPARFLGGLNEEDEDDDVMQIDGQDNTAAKPNAATQALEQSMRKANIRDQEQQQQSRGRERERAERGYGQHSATVAAAARQQVRERNRQRGAFELNLDNATLLGKRNKKVPVMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLB1</accession>
    <name>S0DLB1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to vegetatible incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425271.1">
        <property type="nucleotide sequence ID" value="XM_023573572.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DLB1"/>
    <dbReference type="GeneID" id="35393673"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00188"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_7_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="299"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="554"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1369" mass="155534" checksum="3401ECE28F23EADF" modified="2013-09-18" version="1">MSRKPCLWEEAREGLSQEVQDWLQTISGGLGLGLTATQQVDEIIGHARQKQGQLEKNHHRSLVIETTNHKWDLASYFDRMVHWLDKFKSIGDVASSFDPLHAALPWAAFRFVLQAILAGKEHTDSLVRLLSLIPHFVFSGYVLELVYAQQPICYKQATKVADLGAKIIVNLEDQLLKLYSLIFDALWYCHLAQTRGKTKQRIVALFNFREPTDFLDGLKAQHQQVIECGEECRRISDFSMSFEYINLLEELQGSVADLDGHVLKVLVWVDTQERIRTLRKISDVLFRKHHEEIKRKRTEGTSGSGKTFLISRIIDHCVENAQDDEAIAFFYCKRDEGTRREPQNILRSILRQLSTTSKQSQTGRIHRALRGVPDRLEAIGTTFDIPNCQRLINIVTKDYSRTNIIVDALDECDRDSRWELLEALAAVTNENQGVRLFVSSRTDDDIQRHFQQQPIIRIFAADNNEDINLFVRQRLSKDSRWNDLAPHVHRDIESVFRNKSEGMFQWAALQVKQLCQAASWNESSIKLHLSSAPKGLEALYAIIWHQIERKSEYEKQQAKNAIQWVLCALKPLQTGELSTMMQIDPEANVIGPIEELNDREIQSICGNLLILDKQLHVWRFCHLSALEYIEKNHYSLAEAHYHTSVCSLKFLQRGLRLSSTLSLDGSPSQEDGTDNPSRKARAKVWDGSLVRNDYIIIQGLRHVGLADSPAITNTELAYQLRQFLGSAEVQSPIFQAWKSVLSTFKYRKPHETGFVSLASPPLEVAAIFGLFHSLRDWWDTLDTSVGSNSSALALAIRFRNENIWKHLIERGFGINTGSPRPLTVAIKSGYATAFDTLMNANSDVSYSEDSSGSDTPLKLALRCSNSKHQRRFVRRIVDRGAIINDKTTQQHQSALKLAALYACKDTMQILLVPDRGLCSPNSLLNIATWNSNASLIPFLVKELGADVNKRFSGISPLIKALERMCVPNIQALVALGAQLDLTNHQDRVAALRAVESDPGNGVWRLLLQSGMIINRNDNKESLLSLAIRLHTPSSERLWRILHSRADVNQILQSSVLPTPLAWAAAVQTPEVIDRLISYGANPGLSVDNGLSNAIFAACFHGRPRASRLLLDRSGIDVNQGYRGFFRNMLFSVIAGHRDYLDSKRPWYQRKWDLESRLGYTIWKPEHRKVLELLVTRGLNTYFPLYSHLESSTPVLETGIEKHEISVAWMHSKGDYVLLPLSWFFIVWSLHMASAPQPPLRYRMKRWQFPGILPRKFSLIAQVSVASRKRPGYFLMITVNDDYHSASTFTVRHRIRNATCSMKTNSLWKQYSFKDFYGKNGSEGDTNVSQTKRLQSSLLCRNQYNIALSAYTLQHRGHLGTVGDTDTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLQ7</accession>
    <name>S0DLQ7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to D-alanine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423559.1">
        <property type="nucleotide sequence ID" value="XM_023576561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLQ7"/>
    <dbReference type="SMR" id="S0DLQ7"/>
    <dbReference type="STRING" id="1279085.S0DLQ7"/>
    <dbReference type="GeneID" id="35395526"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02043"/>
    <dbReference type="HOGENOM" id="CLU_020844_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000002">
        <property type="entry name" value="D-alanine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="320" mass="36015" checksum="8EE7978468F2BE86" modified="2013-09-18" version="1">MATMDEVFAGYAKRQATLKASTNILSQGIAWVEGELVPLQSARIPLLDQGFMHSDLTYDVPSVWDGRFFRLDDHLNRLEASCKKMRLRFPIPRDEIKKILVEMVAKSGIKDAFVELIVTRGLKGMRGAKPEELLNNNLYMFVQPYVWVMDPKDQYHGGRAIVARTVRRVPPGSIDPTIKNLQWGDLVRGLFEANDRGATYPFLTDGDANLTEGSGFNVVIIKNGVLYTPDRGVLQGITRKSVIDAARSCGYEIRIEHVPVEAAYQADEILMCTTAGGIMPITTLDDKPVNDGKVGPITKAIWDRYWAMHWEDEFSFKIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLZ6</accession>
    <name>S0DLZ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_00382</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425542.1">
        <property type="nucleotide sequence ID" value="XM_023573356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLZ6"/>
    <dbReference type="STRING" id="1279085.S0DLZ6"/>
    <dbReference type="GeneID" id="35393867"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00382"/>
    <dbReference type="HOGENOM" id="CLU_015741_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="57"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="299"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT63461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="396" mass="45973" checksum="4C48DE80AF70996A" modified="2013-09-18" version="1">MSEENGKRKAEEEPSSPTPSKRIKQDDSAEPPEKKPEIKRIPFPEKPAVIEERNGEIEFRVVNNDNERESLIILTGLKCIFQKQLPKMPKDYIARLVYDRTHLSIAIVKKPLEVVGGITYRPFKGRRFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSDVMHFLTYADNYAIGYFKKQGFTKEITLDKKVWMGYIKDYEGGTIMQCSMLPRIRYLEMGRMLLKQKECVQAKIRAYSKSHNIHAPPKEWKNGITEINPLDIPAIRASGWSPDMDELARQPRHGPNYNQLLHLLNDLQNHNSAWPFLVPVNRDDVADYYEVIKEPMDLSTMESKLEADQYLTPEDFIKDAKLVFDNCRKYNNESTPYAKSANKLEKYMWQQIKAIPEWSHLEPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM12</accession>
    <name>S0DM12_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable translocon subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_01737</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425561.1">
        <property type="nucleotide sequence ID" value="XM_023575384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM12"/>
    <dbReference type="STRING" id="1279085.S0DM12"/>
    <dbReference type="GeneID" id="35395222"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01737"/>
    <dbReference type="HOGENOM" id="CLU_133423_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT63480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="140" mass="14616" checksum="AABFB3D5EAA48D4C" modified="2013-09-18" version="1">MSSPRPSSPVNGGAAASGANIGRPSSPAIPGGPRTAIRRRAAADQKEKIANARPSSTRAAGAGGSSSTMLRLYTDESPGLKVDPVVVLVLSLVFIFSVVALHSTSPLDPLSLQFYRQDYPKVLQLNCTTTKGKLDGKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM25</accession>
    <name>S0DM25_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to putative snare protein syn</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425567.1">
        <property type="nucleotide sequence ID" value="XM_023572685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM25"/>
    <dbReference type="STRING" id="1279085.S0DM25"/>
    <dbReference type="GeneID" id="35394136"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00651"/>
    <dbReference type="HOGENOM" id="CLU_042423_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF380">
        <property type="entry name" value="SYNTAXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="219"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT63486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="378" mass="41423" checksum="CF3FDE0216DEB31A" modified="2013-09-18" version="1">MSYGYGGQNPYDSPDQGYGGNNGYGNGGGYNSPPAQGYGGIGSVEMAPLAHNAGGFGQGDPNAILNECRDIDRGIDTVEQNLEQLRMIQQRTLDDADSSGSSAASRQLDSLSADTMSLYRELTERVRTVKSNPEAKSPKNNPHVTRIDRRLKAAITQYQQVESQFRKRTQDQMARQYRIVRPDASEQEIQAAVEDTTGGQVFSQAMMQSDRQGRARAALSAVQDRHQALIKIEQQMVELAQLFQDMDTLVVQQEAAVTQIEQKGEEVVENLDKGNEEIGVAVNTARKTRKKKWICLGICVAIIVVIVIIVLIYIFVIKGQNNNNKKRSIEAAIGSLPVMHTAVLPARLARRVAADNTASSLLNSVGGGRFHLPQLPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMA8</accession>
    <name>S0DMA8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425845.1">
        <property type="nucleotide sequence ID" value="XM_023571559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMA8"/>
    <dbReference type="STRING" id="1279085.S0DMA8"/>
    <dbReference type="GeneID" id="35398559"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05078"/>
    <dbReference type="HOGENOM" id="CLU_548642_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="488" mass="54995" checksum="71BDCA0DC7BCA179" modified="2013-09-18" version="1">MSYEDTQHLLDSITDPDFDQRLMGHTSGQATKEVDEVDMFTGLNNSTSQNPHAELGIENEDLLASNPFEKEFMEAYEAENVRAQASSESDAQMSGPNNNGSTIADDDSQVPVSTAVTPATQFSSPMNPEDYLSESFQTQPYPPLNNQPQPYPAPMGQPFYDQAALQQMQPFQVRQPTGLGGRQMRQAQYPQQQFFFSMNNQLHQPLSGQASHPAFQSRNPPPQGPPRKGPAPSEPTRHKIPTNPANINPHTVEQQSLLLELQHFTHEYQGYITNPVQARQIGNLFLSLAHHEVTVTPPDMDPTFPRTNEAYRARVQELFMAIVDWSNPRGWRTKMGTKLAVQWVEEVKVYRKSVGLSVEPSDMLDHQIEPPLERMPPVNEQWKNVVHRQLSNIEIEILSSKILDSAMLSQQDRNFDNKVLIHSALRSSWLSRITNSPVAELVRKENNKAGNDKKRNAASRLSGKGAKRLQNEGSEGEEDGRKTKRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMK2</accession>
    <name>S0DMK2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425742.1">
        <property type="nucleotide sequence ID" value="XM_023571437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMK2"/>
    <dbReference type="STRING" id="1279085.S0DMK2"/>
    <dbReference type="GeneID" id="35398668"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05187"/>
    <dbReference type="HOGENOM" id="CLU_011409_12_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="366" mass="42408" checksum="08FAF5B76DF75974" modified="2013-09-18" version="1">MHYNKAISILTRDTKPCVDTVLLVCMMFICIEFLRGNREAAVTHASHGVQLLNSEGHRSRLANTFAQMSVCPLFFIEVGTDFPLLQGDEGADLKNPVFYTISEAQHALEHLSIRIIKLVRDGNAFRLHVVDEVPQEWILDEQAEAKQDLEAWGFAFERFQDNRPFGEDSEDLPTLALITRYRLMKTWVVNCFERGEMGFDRMKDDFVTIVDCARRAAEYHEAQRTTPGKFMFNVGFNPMLHFTVWKCRYLSLRVEALSLMRRLSSQQEALWDAALLYNVSRRIIEVEHGIDLSGDYDLYDERLPPDENRVKGFFFREGPEAESIMWDKNAETVYFLMAHPEGGVLFRKDYVKNKDLVSDCGQTFWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNG7</accession>
    <name>S0DNG7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_00448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425028.1">
        <property type="nucleotide sequence ID" value="XM_023573282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNG7"/>
    <dbReference type="GeneID" id="35393933"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00448"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="58"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT62947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="497" mass="54760" checksum="D2BE5B5CA716E33E" modified="2013-09-18" version="1">MSSDVEMEKVPIPVPFPPPAAVDDVDSTLGKDVDAHIHYVEAISDLEKQLLRKQDLRIIPLSSAIYFLSFLDRTNIGNAMILNSSTDNDMQRETKMTDHQFVISLMLFLVSYAVFEVPSNILLKKLRPSRWLAFLMFCWGAMTILTAATNSFGSVTAVRFLLGVFEAGLFPGLVYYLTFWYKHDERSVRVAFILASATLAGAFGGAIAYGIGHMNGTAGLSGWRWLFILEGIPSCLAAFLVLFFLPDWPERAKWLSEAEKDMAIHRMYHEGSKESHPTMTWAEAKETLMDWRLYAHYAIYFASGPAFASLSLFAPSITVGLGYYDLKAQLMTVPPWAIAYACQVLVAWSADHFNARGVHTAMAAAVGAIGFIISAALPADAYAARYGGLIMATAGSFACMPPMLGWLSSNVFTTASTGLAIALNVSLGGGIGQIPGVWIYQTSQREGGFTTGHWVNAALLLFVSVVALGLRMFYGWKNRKLREYAESRAVPYRCYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNQ6</accession>
    <name>S0DNQ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_04578</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426305.1">
        <property type="nucleotide sequence ID" value="XM_023572120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNQ6"/>
    <dbReference type="STRING" id="1279085.S0DNQ6"/>
    <dbReference type="GeneID" id="35398059"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04578"/>
    <dbReference type="HOGENOM" id="CLU_003041_13_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="228"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="462"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="80"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="666"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT64224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="749" mass="80944" checksum="16240C4DFC8CE98D" modified="2013-09-18" version="1">MVLPSKKRKLPTATGPASKRSKNISKKKSGGKESRRAVDATALAWSSVGEDFGGLEVIEGVDVVKDGSKVQFLVAGDKSNIIDPQQEVLDGDESFEGFGDDPVEVGDIDSGEAGSGQGGLESEKPQGKNKGKAGQGKAEQEKTKKNKNKNKLDGKNSGAEKEDEQLDKASKVVQKSSARGGNTFGALADANDYADQEDVDMAAWVPLNLSPQILSAIAKLKFTKPTLIQEKTIPEILAGDDVIGKAQTEQGVKRTGPMAVVLSPTRELAKQLGDHLKALCDGLPSAPYVCVVTGGLSIQKQQRQLEKAEIVIGTPGRLWEVLSGDRALQSKFAKIKFLVVDEADRLFKVGQFKEAEDIIGALDGKSPGDDAESSDEDEEEDEEDDESSARQTLVFSATFDKDLQTKLAGKGKSTGSDEEKMAYLMKCLKFRGEPKFIDVNPVSQMAQGLKEGLIECGAMEKDLYLYTVLLLNPGRRTLVFTNSISAVRRLTPLLSNLNLTALPLHSQMAQKARLRSLERFTAARNSILIATDVAARGLDIKQVDQVLHYHVPRSADTYIHRSGRTARGESSGVSVILCSPDEVLPTRRLASKVHAERSLGAKREHFIQTLLIDRKMASRLKPRVDLAKKIADTVLAKEKAHSDDTWLRNAADELGVEYDSEDLEAVNASGGKGGRGGGRRRKEQAAKSLSKAEMGALKAQLREELSRRVNLGVSERYITGGRVDVGALLREGKNGGIFLGNTDGLGFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNX1</accession>
    <name>S0DNX1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425163.1">
        <property type="nucleotide sequence ID" value="XM_023573440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNX1"/>
    <dbReference type="STRING" id="1279085.S0DNX1"/>
    <dbReference type="GeneID" id="35393791"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00306"/>
    <dbReference type="HOGENOM" id="CLU_008702_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="388"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1116" mass="125967" checksum="66410EE8ADFDCAD2" modified="2013-09-18" version="1">MDKIPAQDAPAAWPPKKADKPRIFGLTQVYPDPEDALATEEKEIDIFVLHGLDARSDKTFIAWRVDGDKSSGDVHWLSDEDMLPSQMPQARVITYDWNANYDKTASKETMRNHADTLLERVHLNRDALKRTQVPIIFIASCFGGVLLIPQALVGALELQHARSEQRRQIFDSCIGIIFLGTPFGGSWDTGTKAARLRIEAAKKANLEDNIQYSMELVQYLKEGTDDNPSPLDDLVHRFKESIHNPKFRIPCGYLYETQPAQYAGPLSRLTSEHRKSQTVIDKHGQGIVVSHKSAVVGGGDGSAQPMRHNMMHKYNSPDNPAFQSLCLRLREFAQKADDTIDLRDRARLSDLENLARNDLKSWSELFSFPNMNRRHIDLGFKENKAAPGTCEWLFDQDAYKAWESNDSSNSTLIIQGKAGSGKSTLIYEAVARGQTMHKTICLSYFFDAAKDEGLPIQISPQGLYRSLLSQLLSKLSRSPAVVAILREWGPAKEARQETVEDVVILKHRIACLLAALRGRTVRICIDAIDKCGSGRDDGTDSTIDMLRYIQGLNGKGAKLLVLFSIRDRAQYGSYLSAPTIEIGSHYQQDIYKYLNNELKYSRDPATREQIIWTLLRRSSNNFLWVKLVVASLNAKTDAGLADGKWRDEMDRLPKELGSLYSDLLNNLDSEDRAEALILLQLTQVRIRPLEVMEMHSALEYARGTDNRPDKDGRSEEVFEAHIRRIGRGFIEIQVIEDPHGLSHRWGLRSIQAAQDFEDLGELLEEEVWIPPAPKRLVQFTHDSVRDFLDKYVFTENDIKPCDGSSGHRAHFEITKLCMRAAGHGSKQECFLPYAAHFWTVHARKANEAIVDKFQPPKFITSCDYKTKGILARYKEHATEPYSLYHLPRSEIPNTGWLTAKATMLTLLAFEGCGALITKHGEMCKRKDCREDESTVHDAFALALLRGWKAGVEAVRDLAEKRSIALDPTIKPHFTKGICPLRRVCTRNQHEILESVMNIGWDTTCRAARVSFCEGVKFGHERIVELFLENAGENTMDLLSWQSGQGYTALHFAASAGRWRIFDMLLVSLDDIPPDLLNLKAKGGETVLDMAQRGKIKHGMRRDSDQIIEILQEILEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPB6</accession>
    <name>S0DPB6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Peroxisomal hydratase-dehydrogenase-epimerase</fullName>
            <ecNumber evidence="5">1.1.1.n12</ecNumber>
            <ecNumber evidence="6">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Multifunctional beta-oxidation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">FFUJ_04513</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.n12" evidence="5"/>
    <dbReference type="EC" id="4.2.1.119" evidence="6"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426361.1">
        <property type="nucleotide sequence ID" value="XM_023572191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPB6"/>
    <dbReference type="STRING" id="1279085.S0DPB6"/>
    <dbReference type="GeneID" id="35397994"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04513"/>
    <dbReference type="HOGENOM" id="CLU_010194_18_0_1"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000410">
        <property type="entry name" value="Peroxisomal multifunctional beta-oxidation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ketoreductase" evidence="22">
        <location>
            <begin position="315"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCT64280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="899" mass="96973" checksum="8A0925AAA8519C74" modified="2013-09-18" version="1">MADQLRYDGQVVVVTGAGGGLGKAYATFFGSRGASVVVNDLGVTSKGEGNSSKAADVVVNEIKAAGGKAVANYDSVENGERIIETAISAFGRIDILINNAGILRDISFKNMKDEDWDLIYKVHIKGSYKCARAAWPHFRKQKYGRVINTASAAGLFGNFGQTNYSAAKLAMVGFTETLAKEGIKYGILANVIAPVAASRMTETIMPPDVLANLKPEWVVPLVAVLVHKNNTQETGGIFEVGGGHVAKLRWERSSGLLLKADESYTPGAIIKNWNKVVDYSNPQYPTGPNDFLTLLEESMKMGPSEQGEKLDFTGRVALVTGGGAGIGRVYALAFAKHGASVVVNDLADPEPVVAEIKKLGGKAVGVKASAEDGEKVVKAAIDAFGRVDIVINNAGILRDKAFSNMNDELWDPVLNVHLRGTYKVTKAAWPYFLKQKYGRVLNTTSTSGIYGNFGQANYAAAKCGILGFSRALALEGQKYGIYVNTIAPNAGTAMTATIMPEEMVQAFKPDYIAPLVLALCSDKCPNPTGGLYEVGSGWCGQTRWQRTGGHGFPVDVTLTPEEVLKNWKDIVTFDGRADHPSKSQDSIGKIMANLENRSKPKESSGETNYLKVIEETLKKEGKPTEYKYEERDVILYNLGVGAKRTDLKYVFEGSDDFQVIPTFGVIPPFNAEMPFEFDNIVPNFSPMMLLHGEQYLEIRKFPIPTNARLITRGRLLEVIDKGNASIARTSTTTVDANTGEDVFYNEANVFLRGAGGFGGPKRGADRGASTAANKPPARAPDVVVESPTHDDQAAIYRLSGDYNPLHIDPAFAKVGGFKAPILHGLCSFGIAGKAVYERFGAFKNIKVRFAGVVIPGQTLITEMWREGNKIIFQTKVKETGKPAIAGAAAELRTDGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ26</accession>
    <name>S0DQ26_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to C-term. of A.nidulans regulatory protein (QutR)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426611.1">
        <property type="nucleotide sequence ID" value="XM_023572499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ26"/>
    <dbReference type="STRING" id="1279085.S0DQ26"/>
    <dbReference type="GeneID" id="35397721"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04240"/>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="275" mass="30592" checksum="C1C3C6101015E6A9" modified="2013-09-18" version="1">MASNTKYQPAPQSDPDDYTHAPPAYAEGSAARDETQGLFGAPRDSEDNLPDDFKFGGSVAEATVDIRNQFVRKVYTILTVQLLATAGVSSLTFFSTGYKDWIQSHPGVVWASLFGAMIFMGLTYWKRKSYPTNLLFLSLFTLAEAYTISVIVSFYKTSIVLNAVVLTAGIFVFLTLFACQTKYDFTSWMPYLFGALWGLVIFSFMAMFFPYSSTGELIYGGLAALIFSGYILVDTQLVLRHHHVEEEIAAAISLYLDIINLFLAILRILNSQSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR23</accession>
    <name>S0DR23_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to KH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425948.1">
        <property type="nucleotide sequence ID" value="XM_023571684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR23"/>
    <dbReference type="STRING" id="1279085.S0DR23"/>
    <dbReference type="GeneID" id="35398447"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04966"/>
    <dbReference type="HOGENOM" id="CLU_012058_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="231"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="441"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="511"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="596"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="857"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="829"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="932" mass="103458" checksum="8709DCB32A809433" modified="2013-09-18" version="1">MAPNFVMGRPNMPMNALNHPKNAAQPGQPMASPQAADATILYSFNIPFASDLAGPDTEDILHATTDAVLRWTHPEDAPDDVQIHELPIHVQNLNNLHRMCQEITNGPLPVEAYVLSTMLKGGKGQQVATVCLSGSPELVHKSRETILNDTPISLRCTTIDIDGQLVCDLNAGVLKKPVTDTLDYISTFCGVDIFLLGPKLTPVVDGMTGDAELRMDQRWRVAIYGDILSSEHAKARVLIHIDTLLGRIVDGTKLEASLHQLVCGRHRKNIKLIESSTGTAIYFPPPFSEQKLHETVQRIRLYVKDVTIPAAKIDSILLGRLDKVRKILEANGTFIMFPPLATQRNMVRVQGSEGLHVERTVREIMSLAGQFYSAGWFIQPADARQFPHPNDIKSLLVDICANSDADLSFDKLSFTITGSDDAVKTALQVISEMKFISQSQYQIRVKIELANEHKEFVSGKKNGKINKIMGQSNVQIIFDGFNEYNFNIDVMAATYESMKQGLTLVEQEMPASISFHVPDQYHKRIIGIGGQHIQRIMKKHSVFVKFSNAMDRGGMGREDDDIKVDNVICRTPARNAQNLDAVKNEILEMVDRADSEYTSQIVSVDRLYHRQLIARLPEIDDLEQKYNCKINFPSTEQASDEVTVNGPQWQVPHCVDEFLGMVPDKHELVLARTPELVKFLESPEFAHDLVPKLKAQHEVELSVRQNPDELTESGEPTVTLLWGFTRNNAGGLRDAMDFIQSQFATSGAEINVVKGALPRPKSDSFEDSLQYFDSKLLQHAPAPVATDSPIKTGFGDEVARERSSILDRLRKPGSMTSISSFLDRRKNSSHSGNSNFFKGSSNVSKSSLISIESTRSFNADRNPWNDSGVNLPDDDNPWAPRTFGTHMDNKLSIPQPGDVTPRHSTRASGDSGRPSTSHSMNSGYPAPIGPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR77</accession>
    <name>S0DR77_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427042.1">
        <property type="nucleotide sequence ID" value="XM_023573021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR77"/>
    <dbReference type="GeneID" id="35397251"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03770"/>
    <dbReference type="HOGENOM" id="CLU_2146070_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT64961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="112" mass="12159" checksum="FBC8981564061C92" modified="2013-09-18" version="1">MSSTPIATRYYNLVNDGVGITIFPKILTPGGDKLWDGRNHDGYTVNVGESRSVDLTVFGIDIGTLFVLSESTRFGEDETESSQVFSFDPTCTVTANEVRGGSACNGSLEYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR90</accession>
    <name>S0DR90_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426013.1">
        <property type="nucleotide sequence ID" value="XM_023571764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR90"/>
    <dbReference type="STRING" id="1279085.S0DR90"/>
    <dbReference type="GeneID" id="35398377"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04896"/>
    <dbReference type="HOGENOM" id="CLU_038171_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13527">
        <property type="entry name" value="Acetyltransf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="172"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="378" mass="42625" checksum="8F7C945B95B733D5" modified="2013-09-18" version="1">MASTEALPPVTSPSLILTNPTSSERELVWKGTQPHWGAALSMEDYIAREYDNLEAPLARDGGVTSWILTDGDKKPGERPLLSSCETYNKRAFVRTKDGKARDGAAHGVASVFTFPEYRGKGYARKMLSLIADELKSRQQKNEGAADFSVLWSDVGPKFYQTVGWEPFKSTYLEFPVTETEPTTDSSLKPIALDDIPDLAARDEQLLRDRISKSSQVSASVVPDITTIKWHIHRENFMCKHIFSRTPTVHGALYTPPDTPSSRIWALWTCSFYGMLDQPEKNVVRVLRLVIEDESISDETLTKGIQAIASFVQKEAKEWKCSKVEVWNPENRVRRVTEGIQSLGAKFIVRENSNIASLNWFNGSDQEVDWIANERFAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS01</accession>
    <name>S0DS01_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to DAL5-Allantoate and ureidosuccinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427296.1">
        <property type="nucleotide sequence ID" value="XM_023573841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS01"/>
    <dbReference type="GeneID" id="35395626"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02144"/>
    <dbReference type="HOGENOM" id="CLU_351255_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT65215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="801" mass="87388" checksum="CF38D1BAC6F784CB" modified="2013-09-18" version="1">MDLKEGHNLSGPNKAAIELATMDASASVGETNSTFIMTPAEERKLVRKIDLHLMPLMFVLYLLQYLDKTSLGYTAIMGIIQDAASQPIPISIRNLNANNNVAEPQWYPILLDFELLLRGISRSQSSIFNSLGEILSIQMVMAAGKSFASLAVLRILLGAFEAAISPGFTIITSTWYKPSEHALRHGLWYCGASVAYIIGGIIAYGISHINSAIKAWQFLFIIFGAVTFIWGLVVWWLLPTNPQSAWFLNEHERKLAFERVQGARHSVETGEWNYAQMREAFMDPRSWLFFLICVFSTIPGGGMTAFGSIIIKDFGYSVLQTQLLSMSVGAFLLFFVIMTVAISMTLKNSRCLSISLLNFISLAGVLMVKLLPESNKTGRLGGLWLVCAHASAFPTILSLVSSNITGHTKKATVNGMLFIGFCTGYIIGSLTFIAQEAPAYKTAFNIMVACFVLNIAIIISMRQIMAKWNNQRNQEYGPKPVSDGLILEHGRQVDLDETDWENKDIRYFDFSERTLKLLCIGIEDVLIPAHQTRGTSSLDGKTAIVTGGSRGIGQAISINLARKGLSKLAITYSSNIKAAEETLKICQELGVKQAVAIQADALDPEFGPKTVAQALERLDTTVINILVNNAVLADHTKVLSIKDTTLNIFLEIMQANVYAPVSLTTSLLPHLPEYGGRVINISSVLAYQGNADPTVAYGASKTALQSYTRSFAENFSKYKNATFNSVVVGLTATDSIKASQHMMPPGFLDGQIRDTTAGNRIGVPDDIVYVVGFLAGEEGRWVNGAAVSANGGNRLLIPVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS49</accession>
    <name>S0DS49_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425474.1">
        <property type="nucleotide sequence ID" value="XM_023575872.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DS49"/>
    <dbReference type="GeneID" id="35395178"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01693"/>
    <dbReference type="HOGENOM" id="CLU_004198_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1370"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1403" mass="159553" checksum="BCBB721D8514BEEB" modified="2013-09-18" version="1">MAEPVDEGCPSRIPELNLAGNPPLDDAPASASSPTLARRSDRIQDLLEIILLTFRFDFERLPPEAQRSYNRFLENKSYHEFAARLKRLVLGRRLDGFMEGSSSCLIAVTKLFDSRYPHLGLKKLRDDLVSGRKRAGLGAVSRRRAQKKTLRETRNEQAGESSRRSSQANLASTITLPGRVRTRARPEGRVVHWARIEPSSTQADPETAGPSSDIPPTPIDAVEAADNLEDRSAPTQRPLIPGFAISTRTAPVDQGSNQPAVEGSGREQTHQEENIAWLKDYNEALGGPKYDFNLYPYKGWKIEPPEILLPRAINFLADEDIDRTLNWGQKIAELTEYFSYLLHNWQGEEWGTELHEAIDMLHTHWLFEQYHYGKPKLNLKFDNVWPKHSKRLPPILGVETTVEKPQSEMGERRLLLNEIRPAIDIHYELPGDVLEKYIDLYASKASNYWESAPHSLFSRHELVKIENNAFEKCIFSGMSTTDRLIRASEAKFKSESHRKNFSPGALQAFATLRGSQRAAFQQTLNTLDNSENLAVCNIFRTLILPPPKIPEKPDAGVLLPTIQVADVPEEESRDPFSYTVAHRWYLEAERFWKDWSNEHAVKQCYSHKQWAEREQPIMDLPKNWLGPFVHDFLDHDMKKTLEFLRRCETLLRRIFLQDERVPRPFLAGMKQLMLAGLSGRPWDEIELDFKGEDFVSDSQDLAHIRPLEEGFLRLLGMESIHSNTVDPEINHDGTSPLSSIFEQRVREIMYPRGSSTVASYDFANFMVLLNEVCDGPVKRWRFSNEEALEELELLERRGVVKLNENNSVSSSVPNLHPEQRVRWLDTDDDLDAFMRGVQATRADQPDNDDSDDGDDSDDSDDSDDEDEIMTISTDVSVPKSEDLGNYMFGLPKIENLHSWVELGTAGGREASEEDMPRTHRFFQRLCFRLGRTIKDLRERMETYKRQLTPEQQDRNRCFLDTMVNEWESNTRTRPELRRYNPNKPVDEVFAQTDYAEIMHVCQHEHDFGKSGYPEITYGCQNESYRFSVDVVRKAILREAYENKSMLLPNRIDRSVDEKGLRTRSPLRREPVWSFAHPDRRGKAPRFWDINRWPLYLQSESTAESIRSGRCYKPVPSPLAPGSNKGPRISVRFATPPVSPISSGLPTFQRELHGEVQPEATTMASDMIESQIYRFPGFGEKFTVTFQDLADSRRTFTTGSSQYLLGDTPLQKKHIEDLIKSGIQTEEPPTWTQRLSALFGRKNDPVDPGALPKVNPRDVPKSKPRSEPEDSSDEPAQGEDSSAGSEDLEMDESAIQLWEESQAGPSSERRSSSAQAPSPIDPSLPTEPGPSSVSPTEPGTTQGGSSSLWGRGLPGALPKRLRLRQATTEIQSYPVELEVIEPESGLPEQQEEDEKSDNDSLFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTB7</accession>
    <name>S0DTB7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to krueppel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_02801</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427905.1">
        <property type="nucleotide sequence ID" value="XM_023574576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTB7"/>
    <dbReference type="STRING" id="1279085.S0DTB7"/>
    <dbReference type="GeneID" id="35396283"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02801"/>
    <dbReference type="HOGENOM" id="CLU_036835_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT65824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="349" mass="37344" checksum="3EB262A650219FFB" modified="2013-09-18" version="1">MTMTLDTTQQRFGPSLNFDYSAPAQPPAFSNPWSSSPSQHPPAGSSLFVGSQPALNPSIMAGKPPQSRASTSSTSSMASYGGGMPVPNTSADLLSINRMQTTSAAYGDPTYTTSASPVNHQFAPTSAAPYDTLGYAPAPVRPPPFGLAPADDHARRYSQHSIQDERRSFADALDASHGMLAMSQETPRPIYGARSDRSSVDSYGFPSTHSTSSSISSSGNFSSYYGDSVSDYSTAGSDIESVSSRTLPRPQGLMGSQIPPAPQSMMGQFSSKVSSSTQKKHKCKVCDKRFTRPSSLQTHMYSHTGEKPFACEVEGCGRHFSVVSNLRRHRKVHRGDARSEAGSEDHHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTT6</accession>
    <name>S0DTT6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
            <ecNumber evidence="13">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_02972</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="13"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428060.1">
        <property type="nucleotide sequence ID" value="XM_023574765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTT6"/>
    <dbReference type="STRING" id="1279085.S0DTT6"/>
    <dbReference type="GeneID" id="35396454"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02972"/>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008442">
        <property type="entry name" value="Propeptide_carboxypepY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05388">
        <property type="entry name" value="Carbpep_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13 15" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006530141" description="Carboxypeptidase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Propeptide carboxypeptidase Y" evidence="14">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT65979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="541" mass="60366" checksum="59592B3542B9083E" modified="2013-09-18" version="1">MRLSTSALVLGAASSAVGLQEQQVLGGDSKPLVDIDINAWTKPLEKFFGEISSEAKAVWDEVTLLAPDAVEAFKKQVLTQPKKANRRPDAHWDHIVKGADVQSLWVEKNGEKHREVGGKLENFNLRAKKVDPSKLGVDKVKQYSGYLDNEEEDKHLFYWFFESRNDPKNDPVVLWLNGGPGCSSLTGLFLELGPASINKKIELVNNPESWNNNASVIFLDQPVNVGYSYSGGSVSNTVAAGKDIYALLTLFFHQFPEYAKQDFHIAGESYAGHYIPVFANEILSHDDRNINLKSVLIGNGLTDGYTQYAYYRPMACGEGGYPSVLSDSECQSMDNALPRCQSLIKGCYESGSAWSCVPASIYCNNAMMGPYQRTGQNVYDIRGKCEDSSNLCYPGLGYIADYLNREEVKEALGAEVSSYDSCNMDINRNFLFAGDWMQPYHQLVPNVLDKIPVLIYAGDADFICNWLGNQAWTDKLQWSGQKDFSHAKIKNLEHDGKEYGKVKSSGNFTFMQIYGAGHMVPMDQPEASSDFFNRWLSGEWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU36</accession>
    <name>S0DU36_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to rat omega-conotoxin-sensitive calcium channel alpha-1 subunit rbB-I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428052.1">
        <property type="nucleotide sequence ID" value="XM_023574756.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DU36"/>
    <dbReference type="GeneID" id="35396446"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02964"/>
    <dbReference type="HOGENOM" id="CLU_000503_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001484">
        <property type="entry name" value="HEAT repeat containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1882"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2060" mass="223168" checksum="C2389EEDF4733F8C" modified="2013-09-18" version="1">MSSTQEPEGPAPAPARNPEAQAPSDTATTNPELDLPKLQSLPAEQQDLFLLTYVSSLTKHVLDLAADDCTAQQFYLKKEIFQIINLSSPQPSRVVRNNLGKCLAHIFGVGDRKLLFETINDLIAIVSSGKSKSDAEIRTKHAAIVCLGDVFASAGDSAIGLHPLACSTLLKLLKSSSNNAGIRAACLTALGKIVGMVEGSMDEVIARDIWKQGRNHASSDKGHLVVASACWALKTLFRHTPYFLYSSDLDKLEAATSKAFDSPSVQVRLAAAECFAEALFQGHSEGGPPEVASPKGKKTKKALKRQSTIPNIADDELDIPSRSASPAPSGKRSQVLALSLTDILKNLASQYVKSTASNRIRAAIGVCYGKLFRRLGEKLVETNYLKIVESLAIDVLGHSTIASNRYRLLISRNIVDVVIQDVIGRKILGESGQISAAKSLINNIFKNYPQALAERPEPSKHTLIATLSAVSSLIQSLGSAANTFAESCRDGLLQVLQHSSYTVQVFASHCMKTLVLACPQQLLPCLSVCMNSLNRELSLLGSGRNSPRRCIGFAHGLAATLSASPARPLYGSVEINSRVLTIATNMLKSSSQAQLRVASTQIQVAWVLIGGLMSLGPNFVKIHLSQLLLLWKNALPKPLAKDNTSARSFLEVSFLTHVRECAMGSILAFLEFNSRLLTVDVSKRIAAMLQNTTAFLRTLPSKKISDDVSQRLAPALQLQDLEMMVQRRVLQCYVKLVNLSPAGGSEALLQSNLLTLAISLFADPENYAPNSLSASIANAAATFESVWDVGDNSGFGITGLVAGPRVRKLPGQQENSDDGNTDELDSPEDMINNLLRSPICGSLEHDASVLYIGSTDSFSSPDPPATEVINAAIQLFAFAFPLTPGKVQESILEQIRTFASAGTLIRDPGRKAAINVNLAAAILATMRVAVKETKSPSGDISNQAVEALLQDIVRDFVLDPDEHVRSLGYAATARLCNVYGNGFTNNEIKYLVDTIVGNREPSARAGCAMALGSIQTQVGGMAAGYHLKTILGILMSLCNDPHPVVHFWALEALSLAADASGLSFAGYVPSTLGMLVQLYVSETHHAEISSAITMNLELDLSTTSAIARCVDSLINVLGPDLQDATKSRELIFTLVNRFREEDDWLVQRAALGCLEHVSLYAPGHMQFADYVKLLQKYLMSESTTLRDVSVDGIHNMMKRNPQDVLREAETGFEEQLWLVLDTVPSHDGIRNIIRNWMHHTCLTETNAWLQRFQAVLKMTRARPKTEDSQSGSKGSGLPDLQDEEVAGFAAAAGAAKDEKESKATSEVEPLRWQVTTFALSCIDEMFLIIAKDVTANGESRAQSDLQGKVADVVRMAFSASTSGVLELRIWGLKIIGDILKMFGKTPDPDFEEAMLLEQYQAQISSALTPAFAADSSPELASEAVNVCASFISIGIVTDVDRMGRILKTLVSALENFSKDSENAAIGDLKSLSSNAQVMVKISVFSAWAELQVASSEQKYLLDVLRPHIGTLTPLWLESLREFARLRFEPDISMTLGPPSLSGSLDTIYAALNRETLLRFYQDAWLKLVDAIASLIEQDSEFVFDALDGKESDGPSASGKSKNSDINYRDEPVAFFFVLFGLAFEALATRSGQSDSLATHEQTLAILQALKKILHPSVSGHAIYRPDVFSETMDLLDRLVLTESLDVQGVIVEIASVLCIAHPSARRHATEEGDLSDDIDQLFELTRIIVLVLTGLLPNLSEGNQPARHQMNEEAILLVRSSLNALVDAAEVFPAIIKTDLHACIIHIFATILSTPGCQELIVPQSLSTLKRFVGSMSKSRRNQSNGEPSSTDIQLQGCLRRFLSIYLNAQKREAPQSLTCVKNCLLATTILFTGGQNHLPASEALVARYLEELMDCLTDRMTAKIAANCIKSLLLQPSQTSADLSIARYLFPRLVAFVTDTDPEDPENARSLIAQTLCQYVGTGVRGRHLAAMAVVIPTLMARATAEGEEVYQETSARLLELAAIDQETFRAVVGGMTDGQKGFLEEVIRFGRQTTGQVSKAATGESGQPSIALKMDFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU50</accession>
    <name>S0DU50_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426139.1">
        <property type="nucleotide sequence ID" value="XM_023571914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU50"/>
    <dbReference type="GeneID" id="35398242"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04761"/>
    <dbReference type="HOGENOM" id="CLU_154723_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="109" mass="12084" checksum="189ADBCDE3667781" modified="2013-09-18" version="1">MHISDDFQTLCERVQTMVRQRRRKEKRHMEISAPFGFEKNPVNLPGVSEEQLSMLREQAAASRIGIADPPSPTAPRSPCSTSSLFSHPVRPPIKTAPTSTSLSSTDSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUA4</accession>
    <name>S0DUA4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable ribosomal protein S15a.e.c10, cytosolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_03166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428245.1">
        <property type="nucleotide sequence ID" value="XM_023574982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUA4"/>
    <dbReference type="STRING" id="1279085.S0DUA4"/>
    <dbReference type="GeneID" id="35396648"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03166"/>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT66164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="130" mass="14828" checksum="F2978DEC12708CF6" modified="2013-09-18" version="1">MVRTSVLHDALNAINNAEKAGKRQVLIRPSSKVIIKFLQVMQRHGYIGEFEEVDDHRSGKIVVQLNGRLNKTGVISPRYNVRLSELEKWVVKLLPARQFGYVILTTSAGIMDHEEARRKHVSGKIIGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV85</accession>
    <name>S0DV85_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to zinc finger protein Gcs1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426494.1">
        <property type="nucleotide sequence ID" value="XM_023572357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV85"/>
    <dbReference type="STRING" id="1279085.S0DV85"/>
    <dbReference type="GeneID" id="35397847"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04366"/>
    <dbReference type="HOGENOM" id="CLU_023062_3_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT64413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="559" mass="57322" checksum="02731624716696CF" modified="2013-09-18" version="1">MSRRAPNPAAERAAQNQATIKSLLKLEANKVCSDCKRNKHPRWASWNLGVFICIRCSGIHRGMGTHISRVKSVDLDSWTDEQLQSVLSWGNARANKYWEAKLAPGHAPSEAKIENFIRTKYELKRWVMDGPMPDPATLDADGDDDVPLSIVKEKQVIERKESIRKASLGNSQAPKSIPAPQGDLIGGDPVPVRSSSAAPHAAKVAPKAEPAPPRATSTKDSLLGLDFFGEPAAPPRPASTTGTAPSGQSRPDLKQSILSLYATAPKPQPPTQPQQQSSAGGFGGLASPTFSHQSQGSVGRFNDAFGGLSISNPPKPAAPDPFASLSSASRTTSSSDAFGGLGGGSFFNNNKPSQPAAPTHQQQSSNFSNFGGFSSPPPAASAAPVPPKPAQSSAMGDLFDLSAPVTTSPPPPQPAVASTNSVFNLSSPQSPPAAAPTSTTTTANAAGSMGGFSGADVWGGSDWGAPAAPAPAPIQKAPEPTKPAASDFGWGNTGGAFANTPIVPGASGGFNPIASPKVSADEEFGGWTSSGPAAGGSGGQTKPSGGFGGDEDLFSNVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVR2</accession>
    <name>S0DVR2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin prenyltransferase PAD1, mitochondrial</fullName>
            <ecNumber evidence="6">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PAD1</name>
        <name evidence="8" type="ORF">FFUJ_03691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="6"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVR2"/>
    <dbReference type="STRING" id="1279085.S0DVR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03691"/>
    <dbReference type="HOGENOM" id="CLU_074522_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000001">
        <property type="entry name" value="Flavin prenyltransferase UbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004685">
        <property type="entry name" value="PRK06029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="7">
        <location>
            <begin position="70"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="154"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT66649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="271" mass="30080" checksum="337168A243EDAAED" modified="2013-09-18" version="1">MRKPTQFLRIHSPSKLLSARGLQYQQRQSPLFPHPKQTSGRSFTVPSKPLNPLTTFIPSSIQQAPSRPRRIVVGITGATGAPYAIALLRLLRQLGIETHVVISKWALATLKYETTMTEEQIRSLAYANYTARDVSAPIASGSFQHDGMVIVPCSMKTLAAVRSGYCDDLISRAADVTLKENRRLLMAVRETPLSDVHLDNMLFLRRAGAIIFPPVPAFYTNPDSLEDVVDQSVGRMLDLMGIHTDGFERWDGFKQNKSVVRPAQANKATHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DW89</accession>
    <name>S0DW89_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_02502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428852.1">
        <property type="nucleotide sequence ID" value="XM_023574242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DW89"/>
    <dbReference type="GeneID" id="35395984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02502"/>
    <dbReference type="HOGENOM" id="CLU_182424_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT66771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="67" mass="7576" checksum="096266A328A0CF48" modified="2013-09-18" version="1">MAQTPQQRRRNEAFAKGNEAKMGKSEGQIKKRVEKVQKSPISLFWLSILGFVIFGGLVFEGISRFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DW90</accession>
    <name>S0DW90_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_02614</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427733.1">
        <property type="nucleotide sequence ID" value="XM_023574366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DW90"/>
    <dbReference type="STRING" id="1279085.S0DW90"/>
    <dbReference type="GeneID" id="35396096"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02614"/>
    <dbReference type="HOGENOM" id="CLU_009919_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02670">
        <property type="entry name" value="Peptidase_C19N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="136"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="613"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="823"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="840"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT65652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="858" mass="96363" checksum="D9DF5F5628320DFB" modified="2013-09-18" version="1">MKEFPRKFLSKREKNGRRSKSATPAPVVPTVPDSTSNKNKPRPLSAGAFMALFKNDSAKQGAKAEAEKEKDTAQIEDILRRLDELNITNVTADHVTDIMATKFADHDPNKTVEFIDMEQKAAAGIIIPYDPSVDMVGAENRGNVTCYLDALLFSMFAKIDAFECMLKNDFPEEDNRNKLVNLLRMWVNMLRTGKLVHTDMTKLIQDALADCGWSDARMLEQQDTSEAFAFITETLQLPLLSLQVDLFHQGKKDKDDHKVVYERLLNLAVPPDPEEKGLKLEDCLEEYFNAQVDVKRDSEDGKKLGVEEKSRSETPTLKHRDTIRIITEERGEASTPTSPLVNTPLEITPTSEKGVPLLLADPNVKDGSTPDDEEEGEVTTVEIVKNKPSMRTRSTSVIQRVVLDEDGRPSTPDNVTMLQKAMRKGSTVVKAVTIPAWQFFRLIPWHALSSSEPRNNTEVALNFEQRPVVGICLKRYAMTESGQPKRHNTFIDIPDSLRLPHFMLADEPKAEEDMNVLNTDYKLVLQSVICHRGDSLQSGHYVSFARVAPKLLKDNRRHNFDPPPDYEEAQWVKFDDLQIENRVSYVEDIRSALKEEMPYLLFYQVMPMVEVSPPSVDETETEPPSYNDSKISIELPPTPSRSNRLGSLEEGYFDSTPTLENSQLLSSKPPSIRLSMEGERPRRSEDIDRNPGSLAGDSRRPSAIWTDSTIHTPNSHSPAVTPNEESTASRLSRAASRFTLVNRSRPSSQNGENRISFSMSRLGGLMRPSKEPLTEPKDEANGIGMSSANSTGVLTAEISKESKESKDAVDGTEQLAEPEPEQHHHRHHGHKHGHKRVKSKDKVKNKSGDQPERECTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWJ7</accession>
    <name>S0DWJ7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to endoglucanase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428921.1">
        <property type="nucleotide sequence ID" value="XM_023575641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWJ7"/>
    <dbReference type="STRING" id="1279085.S0DWJ7"/>
    <dbReference type="GeneID" id="35406462"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13006"/>
    <dbReference type="HOGENOM" id="CLU_051064_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485355" evidence="3">
        <location>
            <begin position="17"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="244" mass="26308" checksum="32F368AE18513A81" modified="2013-09-18" version="1">MKFFTAFSALLAVASATPTTSPSKTLDKRATTWCDAFGSLQTEGYTVYHNNWGSGQATSGSQCTTFNSVKNKSFSWPTKWSWAGGNIHVKSYSNVALENINKKVSAIKSIPTKWTWRYSGTNMVSDVSYDLWLAPSVGAANKYEIMIWVGTYGGAGPISDSGSTPLATLTINGAQWKLFRGPNGDTTVYSFVATKNQGNFEGDLLPFLTYLTKSQGVPSSYVATSFQAGSNCVFSTSAYSLSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWK4</accession>
    <name>S0DWK4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428962.1">
        <property type="nucleotide sequence ID" value="XM_023575689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWK4"/>
    <dbReference type="GeneID" id="35406505"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13049"/>
    <dbReference type="HOGENOM" id="CLU_1219769_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="227" mass="25176" checksum="C63F1673995317A8" modified="2013-09-18" version="1">MTQPHTQGNIFYHQAVGHSVPANNELLPNNAGSGGFPVNHQLAGHFELEGSPICRSFDSDSGDLTRNIADHKDQVNPFQGFLTNQRNRAQSSPIEPNRASKIPSPHSLTTVLHKSHSSDEEMMEEQLEHAPVVPQAPGGRRRKRKGQRDKAQDRNQKRKFQAKKGRERRHGQGGQPHPLGPQRQGGSQGEAWRDTGNPPQPASRFNPPTGPRAWRQQHGGRGTVSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX99</accession>
    <name>S0DX99_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Related to multidrug resistance-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_13339</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023576014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DX99"/>
    <dbReference type="GeneID" id="35406793"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13339"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="904"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="944"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1013"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1042"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1126"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="280"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="620"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="933"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1223"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="848"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="848"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT67151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1467" mass="161458" checksum="B60EA28D90322CA3" modified="2013-09-18" version="1">MDGYNSTACGDSLFGPSVWTKGCRGGFDFTLSFQESILSILPSAIFLALAGPRAFYLFRSPDKTKRHATYTPKLITSALYATLQVVLLALVPSAKKLNTRFSLAAAILNLAAAFAILLLAHVEHVKSVRPSFILTAYLFVSLLFDAARLRTEWLMSLNIAYAATLSTSTIFKLALLVLETVEKRRILISTEKPISKESTSGPFSRGFFVWLNSLLISGWATVLTNNDLPTIYEKLSSEKLAVRFGKSWKKATSKSKKPSLFLTTVTVLRWELLGIIPPRVGMIALSISQPFLVSNALRFLTMPESDSTMNLGYGLIGAFAFVFIGSALLTAWYEHLTFRAGAMVRGGLMTMVYGKIFQLPTDDLGESSAVTLMGNDVETLIEKLHMLLVESWANTLTVGIAMYLLAAQLGAVCVAPIVTAIISLLLTGSIGKMMVARQIKYQKATQDRINLTSEVLGSMKPVKMLGLSERFSSLISQKRDEEIKASKHYRVINVYLNCITNCNIGMTEAITFGAYALAAKFGNGEPFSAAQAITALSILGVMMDPLSHLLGSIPGSFSVFGCFRRMEDFLNLEERIDRRQVNGRSKNTSRSSAESSQPFQETIEATPLKTIPVGADGTRIAIEDGNFHWGENAVLQDINTTFPSHKNGSLTMLVGPVGSGKSSLLKAILGETTSSMGNVFLNTSEVAFCDQTPWVMNATIRSNIVAESKGYDSAWLETVIDACDLTIDLGRLPEGDLTQVGEQGVKLSGGQKQRIAIARALYSRKPVAIFDDVFSGLDKVTEQIIFTRVFGKDGLLRKNGTTIILATHAVNRLPESDFVVVLEKGGRLVEQGTYHELRSGNGYIHDLDISSHDDHDDQPSAKTKPGEESGKTDNKDAVEDEPIEVPSDRSVFMYYFKANGIHNMLTQILLIATAGVITSFRYVWVTWWGDGKGRDSRDIGYWLSIYTVLSAFEGILITLAIAMFLLVCAPVSGKLLHSRLLSAAMGAPLSFLHNSAAGSLINRFSQDLRHVDIILPMAFSIFLFEVAACFGAAGLAMAAVSWFAISIPFVIVVLALIQRFYVRTSKQLRLLEIEHKAPLFSHFLETIDGLATIRAFGWIQPYTDKALSRIDDAQKPAYLLNCIQRWLTLVLDMVVAFLTVILVVFAVTLREKIDPSLLGIALVNMMRLGTNMKGIILNWSLLETSLGAIARIRMFCSSAPNEQKSTEDNDPGELWPRQGSLEVKNLDVQYEQTNEPVLRGLSFSIRPGQKLGLCGRSGSGKSSFVQALLRMAEIVNGQITLDGQDISTVPRYLIRQRLSCLTQDPFVFGDTMRTNLDPCNTASDDEIKSALERVGIWSAIEAKIGDNKDPLDEKMDENFLSHGQRQLFCLARALLKRSSLLVLDEPTSSVDTQTDARMQEVIRTEFSDCTIIMIAHRIDTLLDFDKVAVLDRGSLVEFGAPQELLKDEAGVFARLYRANKGRKTEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXF2</accession>
    <name>S0DXF2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_04599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427229.1">
        <property type="nucleotide sequence ID" value="XM_023572097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXF2"/>
    <dbReference type="GeneID" id="35398080"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04599"/>
    <dbReference type="HOGENOM" id="CLU_108580_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="216" mass="24121" checksum="5FFFA1C1381574DB" modified="2013-09-18" version="1">MGACASCLGRGDGNNYDEEEENRLLYDDANGMQYGSFGDQAINGENDTLEAQRENEALQRVIAKTSDNMVDIFDIAPQENTNRGATTPFAYAGQGARLARYQHLVSKLSNQGDNNPASGIKVDWLPEDETIEMQKNGPASIKTLESDEGPLRKFPSLTMRKRKLRAPRVGSQQLRHETVMQYSRYTTDDDTHIRFGVQDRCDCPDLNHHPLVAQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYM2</accession>
    <name>S0DYM2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429755.1">
        <property type="nucleotide sequence ID" value="XM_023576612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYM2"/>
    <dbReference type="STRING" id="1279085.S0DYM2"/>
    <dbReference type="GeneID" id="35408034"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14654"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF124">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="274" mass="29206" checksum="BEBD7AA9405D5EC6" modified="2013-09-18" version="1">MATSTFGPRLAGKVCIVTGSSSGLGRAIALAYSHEGAHLVCADLQPAARASVNGEEEVNTDELIRSNGGQAIFVETDVTKTAAVEQLVSRAVIQFGRIDVLVNNAGISVEAGKEPRRVHETPEDWWDLTLAVNLKSIFLVSKHVIAQMLKQDKSETGDRGWIINMSSIFGLVGGYTNAAYAASKGGVTNLTRTIALDYARDGIHCNAICPGFTETAIFADTIKTRDRDLIRSRHPLHGTGSPQDLVGAAIFLASQEARWVTGVNLPVDGGYTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYQ2</accession>
    <name>S0DYQ2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to maltose permease (MalP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_14671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429767.1">
        <property type="nucleotide sequence ID" value="XM_023576631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYQ2"/>
    <dbReference type="GeneID" id="35408051"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14671"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="86"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT67686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="573" mass="62069" checksum="AA69211D2D021D16" modified="2013-09-18" version="1">MSYHDRKGSDPQEGSIAPSYHELETTRRWQTIPQEDEDITAYDPYTSQTTTQDSTTKQDPPPQQDDEEAQMPLRQALKKYPKIAGYCLAMTIPVIGWGYDLVIVGAVASVDTFKADYGSKIDGEMDIPGNWLSLWLGLPPAGAALGGLLGGWLQNRIGRKLSLLFGTIISVIAIACIFFSHMPEPLNMKRTLLTAGLTIQGFSVGVIKTTCVTWVSENTPTALRGSAMALFPVFTLLGQLIGLIVIKLINDIENSSGYLGAFASQWILSLGPFILSIVMPESPAHLIRTGQEARAIKSATRLFAPKVSPYGAIERIRATIEEEKAITASVNYWSCLKGTNLRRTFIVVLASIMPALFGLELLSNASVFLTSMGMKSGYAIMFTLAGIVAGMLANGIGFWLLSRAGRRSLTLFSLAASTLLYGAMGVTGFWRSETLTWATGGIMTAVIVVCGMGAWPAGYAILGETSSLQLRSLTQGLAGIAEKGFSIMLAVVLPMLFSRDKAALGGKTGFLFCGLCLVGTVLTWFFIPEMKGRSAIEIDHMFEMRLPARRFKGFKMEVHEVQEASPLASHASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ45</accession>
    <name>S0DZ45_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_14670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429766.1">
        <property type="nucleotide sequence ID" value="XM_023576630.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DZ45"/>
    <dbReference type="GeneID" id="35408050"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14670"/>
    <dbReference type="HOGENOM" id="CLU_005594_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485078" description="SGNH hydrolase-type esterase domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="488"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1436" mass="157421" checksum="FDBAF80D1681CF39" modified="2013-09-18" version="1">MQRLRYALALCAAAGSAVARPSLINFGSMSMNNIFGREATDFFNPDDLTFIKKLAAVGDSYSAGIGAGDGLHGEGDENCRRYDHSYPYLINQDERLGDTANRKFQFKSCSGAVIKNVIEDQLPSIDSDQQIILLSAGGNDAELVNILNQCVYQWFALNDQHSTVGKVAEMKGEPWAKGWDWDAASRGCLGQLQYSKNIINTDEFSERIDSMIEATKKKLSSDGMIYYTGYAKFWSTDYGSACDKVSWSTWIFKSYNIWQPAARLEELRRREMNRLVDLINDKIEAAVKRAGDKVTFINYDEYVGHFKGRYCEDGVDESVVDSNTRPELMFYELDTFDPWGNRPWKRSTVEHTNGSFSGDMNTMARAAEFVAPDVTFRQEHKIEDDSEIQGLQAAAKEGATEDVPNLLPDGYGRVFHPQILLHELIANLVLFEVSNRRMEENNMTPESLLDTSVAQCPINPSGNIVLKYKETEPGEAVKKGTELRILPVGDSITVGYLSDRKGGDGNGYRGQLKKDLSGDKVLFAGTESSGTMSDGNYAAWSGKTIQYISDHVDPSLKQRPNIILLAAGTNDMNPNRGISKEGNDPKGAADRLGKLIDKMVKACPDATILVAMIINTCDEKQSPATKEFQKLVPGVVKSRHDDGKHVLAVDFTNFKTSDLQDCIHPTNDGYKLMGDYWYSFIHQIPSSWIKKPVGPDPNGGDGTNGGIDKNIPSPDWGKSPIQVTSKKTVADAAEHATGGKDKCVICNGNPWYKGTGKIAQGGVGKNGDWKYHKDWKAEGEVAEGLGLENQYVRLHDMNGDGKADYIWIHPKTGEITCWLNNLPKPWSKAGKNNGIIGSGVGPAKTIYLADMNGDGMDDYLVVDPDNGSVRVWWNYGPDDSWDNGWKFVPGGEIASGVPHANLETLRFPDINGDGRADYVYIGEGGSLKHHLNTGSVGGRDVLFHAMGGIATGAVSDISKLVFADMNGDGRDDYLIWDEDGGLTGFLNQPTNREGVPLFVNQGPAKTIADGIKKKPSTIRLADMDGDGKDDYVYVGDHGALSVWYNRGTTDDSMAIDGLRFADMDGDGVDDYVWLDPKTGAPTVYLNSGVNDGDSLGWAWSPINGGKPIASGAAPANQVVFGDINGDGLDDYLDLDPKTGLLKAYLNLGRESEWKFRPIGTIASGLGPGKRVRIADIDGDGRDDYIFLKDNGGTTIYRNIYGPDNDGDKYAPMSDADASGINQSPDEIDFIDMNGDGKADYVWTSRLDGSVKVWYNDYPKKPTWREAGEIAGGVGTSGANIRYAKLQKTGRYDYVAVDPKTGAIAAWLNGCGDPDTSKKKHRITIARYLTTVWVIAEKPEDKDFSSNTCFKTGKNGDTRGTPILNTTADDKFPAALKSGDTMEKLYGHTCFYEGSTERVGKLVCDGVSGIRCYKDENFGKTQKCRFGSYTYALYCEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ80</accession>
    <name>S0DZ80_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to transporter (Major facilitator superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_14710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429796.1">
        <property type="nucleotide sequence ID" value="XM_023576675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ80"/>
    <dbReference type="STRING" id="1279085.S0DZ80"/>
    <dbReference type="GeneID" id="35408090"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14710"/>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="110"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT67715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="594" mass="67015" checksum="8DC3A5BBAA6748BF" modified="2013-09-18" version="1">MDRKSDIEDQVKHDVEHIDHLTPQDFTRNANAKIRNPLAGISRADLRTQVNAFCQDYDFQDKIDVFYRGALAAQNPTSYENIEELTNDDKRVLQREVTHKWHLPRSLYYGIALCSLGSAVQGWDNTGANGANLSFPQEFGIEHKTTLIGVINSGPTLFGLLSAWAADPINNRIGRRGAIFLTGLFCIFPVLAQAFTQNWWGLLICRLFMGLGMGIKISTIPVYSAEIAPASIRGGIVTSFQLWVAFGIFVGFCSNLIWYRIGDLAWRFQLAAAFVPAIPVVIFVWLCPESPRWLIKKGRYQDSFKVFCRIRNTEILAARDLYYAHRQILEEKDAFGGKTLARRMWELVSVPRLRRATVASSWIVISQQFSGINIMAFYSSTIFAAANYSTRDCLLASMGFGLVMFIFAFPAVYMVDTFGRRNLLLVTFPNMAWCLLAAGFSFQIDKDSSARVPLIAFFIYLFTAMYGPGIGPLPSIYFSEAFPLSHREIGSAFTICVNNAVGSALTLTFPSLLDRLGPTGAFGFYAGLNVVAFIVIFLIIPETKQRTLEELDYIFGVPTRRHVAYQLRQWLPWFVNRYVFLQKSAKLDPLYQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZJ1</accession>
    <name>S0DZJ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427979.1">
        <property type="nucleotide sequence ID" value="XM_023574665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZJ1"/>
    <dbReference type="GeneID" id="35396364"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02882"/>
    <dbReference type="HOGENOM" id="CLU_2184190_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT65898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="109" mass="12218" checksum="4BE6C53A5EE2A072" modified="2013-09-18" version="1">MAMATIPNHELPTIGNVSSGVQWERNIRIAIVALGHRFSGQGRPLQDPTELDSMSNQSILQIDLQLSLLILLTYSRLLSHFHSEDEQKWGEHLKGATMNHSELLFSVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZJ4</accession>
    <name>S0DZJ4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429906.1">
        <property type="nucleotide sequence ID" value="XM_023576865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZJ4"/>
    <dbReference type="GeneID" id="35408251"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14873"/>
    <dbReference type="HOGENOM" id="CLU_030671_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="37092" checksum="C0BD34B442D524C0" modified="2013-09-18" version="1">MTAQHPDFDQLPLDKTGPRGNAWGLLGKDDQLGTLNYLTDEVVGQAARENFKTGTRLSLNWSMKGASYPKFARKNLELRLINKAPLKHAHDDEWSFNSQCSSQWDGFRHYAYQNEALYYMGRKAEEFAASDHPNSIHHVSAKGIAGRAVFIDWYSWALAQGLEIDAMSSYEIPFDQIAKTLEFQNMSLDFLRAGDIIVIRFGYLYQYENMDAAKREYLDKLYQTQKPDNIGLKPSEELLKFLWDTKIAAICGDARSLEVWPCKDLEWHLHEWLLAGWGMPIGELFYLEELAKTCKTLGRYTFFMSSSPMNVPGAVASPPNALAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0D1</accession>
    <name>S0E0D1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_07106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430409.1">
        <property type="nucleotide sequence ID" value="XM_023577321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0D1"/>
    <dbReference type="GeneID" id="35400583"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07106"/>
    <dbReference type="HOGENOM" id="CLU_180200_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="101" mass="11579" checksum="76FC0F3BBF43DBBD" modified="2013-09-18" version="1">MTPEYETTFSRTLPFTTHKIPQEFYKALCDKFGAWTWICEKKEGNYIVETNKEAPADLKKDLQEKGVLKGDEHLIQAASRYTADMDMRVGAETIESPRSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0H6</accession>
    <name>S0E0H6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430381.1">
        <property type="nucleotide sequence ID" value="XM_023577288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0H6"/>
    <dbReference type="STRING" id="1279085.S0E0H6"/>
    <dbReference type="GeneID" id="35400553"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07076"/>
    <dbReference type="HOGENOM" id="CLU_084521_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="1">
        <location>
            <begin position="48"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="249" mass="28550" checksum="190E811B14878F6C" modified="2013-09-18" version="1">MGCNNSRHILEMESRPIRPVTISSHSVGSVMAPSSIFQDFPETSELSRQQIIDAFQHMAEYLNECGTYVNCVVVGGVVNTLYLRHRETTPDVEFLLHDPASKEYITLSNAASFANKKAQGTLGEQWFNNSMQFFVPRNVQVDILQWAKDQHEVIFEHRGNYGGLTVYAAPWDYALCSKLNSLCDNIRADDMEDAVAYLHRYLTLTRQESLNGNQVNDWCRKYHQDVSREVLNRLGEAYARKHGSWPLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0J8</accession>
    <name>S0E0J8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FFUJ_13369</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429258.1">
        <property type="nucleotide sequence ID" value="XM_023576047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0J8"/>
    <dbReference type="STRING" id="1279085.S0E0J8"/>
    <dbReference type="GeneID" id="35406823"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13369"/>
    <dbReference type="HOGENOM" id="CLU_043308_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="174"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCT67177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="404" mass="45015" checksum="9FEBB97F81A32DA8" modified="2013-09-18" version="1">MADTAEQIEMAPVVEQEEQNMAVATTNTEVAAPTGKKVVKKIIRKKKRPARAQVDPDFVTSEPPPQTGTIFNIWYNKWSGGDREDKYLSKTKAKGRCNVAKDSGYTKADAMPGSYFCLRFARGVCPKGQDCEYLHRLPGPYDHFNPNVDCFGRDKFSDYRDDMGGVGSFMRQNRTVYVGRIHVTDDIEEIVARHFAEWGPVERIRVLNTRGVAFITYVNQANAEFAKEAMAHQSLDHEEVLNVRWATADPNPMAQAREARKIEEQAADAIRRALPAEFVAEIEGRDPEARKRRKIESSYGLEGYEAPDEIHFARGTQAVNPLGRKGFEVEYQERPMIENGESGEPPFQIEEQQPQTQQETGGIFSGSTLAALNKAKVSVASKPKATATTGPLVAYGSDSDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0K0</accession>
    <name>S0E0K0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to USO1-intracellular protein transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430401.1">
        <property type="nucleotide sequence ID" value="XM_023577312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0K0"/>
    <dbReference type="STRING" id="1279085.S0E0K0"/>
    <dbReference type="GeneID" id="35400575"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07098"/>
    <dbReference type="HOGENOM" id="CLU_016578_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF60">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="583" mass="64348" checksum="8C31A6A9D1A77872" modified="2013-09-18" version="1">MADAEEKARKEKIAAAKKRVEQLKKKNNKKATPAAKQTKTEPAETPAPEPVAEKAEAAPASEEKAVEEPKKKAQEKPSAKEPAQPLKVETQESSDEDDDSDEDSSSDEETSASATPSLAQQSKLRSTSFRAGAIASGGAAPGSPFSPDGETAPDIYRKHMARIEELEKENKRLSKEAADSEKRWQKAENELADIREADGEDAVKAGGQEDGLLDSLKSQVASLQRQNTQLQQQVSRGPGHGHRPSMSVASPPADLKAELEAKTATIESMEIEISKLRAQAERHASGSSSDKEQVTALEDKLARAEAAAGKAQRELQDLKHNLERTAEKAVREGSERTSAETKIKTLEHELEEVKSARDELEKKVEALDKKATTLTTLHKEQDSRLQAIKKEKEKAEHDVTELRAQVEKLESENAKLRSRKSMEGGGGLDDEGVDELEDEERQKLERKIRALESEVHELRSGAWIEKRRELEATSPGFHDVDLSPGHAMSPTQRRKSGPGGGIGDFFTSGLNALAGGNDDDFLEDDDMDFDEDAFRKAQEEESKRRIERIKEIKRSLKHWEGWRLDIVENRRGGNEGVGEIFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0K3</accession>
    <name>S0E0K3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_13375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429263.1">
        <property type="nucleotide sequence ID" value="XM_023576054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0K3"/>
    <dbReference type="STRING" id="1279085.S0E0K3"/>
    <dbReference type="GeneID" id="35406829"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13375"/>
    <dbReference type="HOGENOM" id="CLU_010246_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="272"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT67182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="545" mass="60132" checksum="88ABD9AFD91FE100" modified="2013-09-18" version="1">MRTPTSPPSSKFPVFDPHEKPDRYKFKPKRQGIIGRMKESWMTQSQRTRWIKTAAIVFAIVTLFYFISPKGVEVYHEVTHPAQGNNGQSPSDSSYGTDRCTKSFSKDKPIVQYVLMIDAGSTGSRIHVYKFNNCGDTPELEHEEFKMTEKDVGGLSKYNGDPVAAAKSLDPLMKVAMDTVPNALKGCTPVAVKATAGLRMIGKEASDAILAEVRRHLEQDYPFPVVDKENEGVVIMDGSLEGVYAWITTNYLLGKIGGPDKSETAAVFDLGGGSTQIVFEPTFKGAAHGGMPEKLAEGDHKYDLDFGGRHFELYQHSHLGYGLMAARKAIHGALIKDIESKNTDKAWVKQPIVNPCIAPGMNKTVEVTLDGSEEPVEVTFVGPSQPAPAQCRNLAEKILNKDEECKLAPCSFNGIHQPLLSKTFTKEDVYIFSYFFDRTKPLGMPDSFTLREMHDLTQTVCMGKSGWDVFTTIPDAMAELDGRPEWCLDLNFMMALLHSGYEMPIDREVKIAKKIKGNELGWCLGASLPLLAGGSGWSCKVNQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2S3</accession>
    <name>S0E2S3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431224.1">
        <property type="nucleotide sequence ID" value="XM_023578411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2S3"/>
    <dbReference type="GeneID" id="35407817"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14365"/>
    <dbReference type="HOGENOM" id="CLU_1343350_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="204" mass="22830" checksum="B371543C9BF6FA90" modified="2013-09-18" version="1">MPIIKRWASTNAVGTEKLVFRHEFPVKRFCRMEKLRDALGDIFGSDEWVVEYDGDNLVIKVGSRVDLKKELKARGIIYKSMCTARASLWPRLVPVIVHFPAVAFESDVLAWSSFIVSHHPLHATLRDAVPAARSDPATAMREPGALCGPSTVDPKELEVDENIFLIPTSSPQPTTRRLNHDWPAITGVAFLRQHKIDPVAPDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2Y5</accession>
    <name>S0E2Y5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to NPP1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Necrosis inducing protein (NPP1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429114.1">
        <property type="nucleotide sequence ID" value="XM_023575868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2Y5"/>
    <dbReference type="STRING" id="1279085.S0E2Y5"/>
    <dbReference type="GeneID" id="35406665"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13211"/>
    <dbReference type="HOGENOM" id="CLU_062263_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495493" evidence="3">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="235" mass="24756" checksum="C3B7FFB16751666C" modified="2013-09-18" version="1">MVLITQLLSGFALASGILASPIERRAVINHDAVVGFPQTVPSNTAGSLYLKYKPYLKVFNGCVPFPAVDSKGNTGGGLATSGSSNGGCSSSTGQVYVRGGTYNGRYGIMYSWYMPKDSPSPGLGHRHDWENAVIWLSGESTSATVVGMAVSQHGGYDKRTSGTFSGNSPLVGYTAIWPTNHQMIFTNDQGGQQPLIAWESLTAAARTALTNTDFGSANVPFKDGSFESNLDKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E310</accession>
    <name>S0E310_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_13255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429154.1">
        <property type="nucleotide sequence ID" value="XM_023575920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E310"/>
    <dbReference type="GeneID" id="35406709"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13255"/>
    <dbReference type="HOGENOM" id="CLU_1547715_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="173" mass="19494" checksum="AEC76D8906A5F2AD" modified="2013-09-18" version="1">MSSYSSSLSSSYSGSPTSSSASLSFHHHLSSSGRDTGKIGDEMGIIRTWFSVLDDSERSSALHSIAELPSLREIEPLIQALKDRKRELWRQQENLIIQPPVKPKWIMPVFPHNSQDPRWAAKWLRALRLHKYERCLSGMSPAQVSCLEDEDLQQLGIDTVGARAKMLRAIHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3B1</accession>
    <name>S0E3B1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_06906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431414.1">
        <property type="nucleotide sequence ID" value="XM_023577099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3B1"/>
    <dbReference type="STRING" id="1279085.S0E3B1"/>
    <dbReference type="GeneID" id="35400383"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06906"/>
    <dbReference type="HOGENOM" id="CLU_086812_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="7">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT69334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="148" mass="16584" checksum="E4CF018311B576D0" modified="2013-09-18" version="1">MLGIDFVPFYPQSLSQPRGSPFHFLVAFRQWYITTFSDPYYGIDIPGHFFEFLVYVELVVQFPLAIYLTRALLSKQKMSAPAELAGVIYGAVVGLCTAVVCNDMWYLGSEFINREAKQTLLGIYLPYAVIPSDLDVIGYAKAVARPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3I6</accession>
    <name>S0E3I6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431325.1">
        <property type="nucleotide sequence ID" value="XM_023578092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3I6"/>
    <dbReference type="STRING" id="1279085.S0E3I6"/>
    <dbReference type="GeneID" id="35401277"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07800"/>
    <dbReference type="HOGENOM" id="CLU_002517_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="927"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1206" mass="128918" checksum="D7CD8A828D04413C" modified="2013-09-18" version="1">MATEAAVDKAADATASQSQPSPDAENVDPVRSNLNGSAGNDDYENKHITNVEDQLTSADASASGGSDTEASRADASKTKDGEKVHGRAGSTVKKPAFKAVSVNKTFLAAKATANSAATKAAEKQPAGSSTPPTTSATLSSSRPRLIAKTGSSTRDSSPRFSGGVNGGKPGSAPDANAVWNKNRPVPPPEPKKFTDEELKKYGIHMASRLNEDDAPGQNKWADIDDDDEDWAPEAITWGDGTKTTLPHPDEHPPPPSDSGSVASKGKPLDKPRSPAPPVAVSSPLTKSSNLAQGKGLILKSGSQEKPTLVAKPPAPPAPVKSPWAPLPPVEKASPIPEPAGLARPPHHKGMTPPPPKEFAADDFNRWKDSSSHGGRELFNSHSGRYEPVHDNRRGSMRMEQHPRHHPSLLQRPAQPDYPAEPSGAFQTNRVSQEPPFARRRGSSNVSGGSGSFMQRMNKGGEVPMPPHELQEGRRPSFVGSVDGLVSPNLSASVHGPTRGQHHSSWMPPRSSPNPAFAQPHHPAPLPEQVAGPPPPLQPASEEVEYQKKLMRERVELARKRRQEEEAREEAERRERIQKKLDAMGPAPEKKTEKKEPAEKSDDVSHPTHIQQREHSSVANQIPTQLQQDGDHSVTASSARQHPQDSDAKVGHTQGTAPAARRVSHSQEAKPSELWGAAAASRQDRAVSNWGTGSQPRNNVWGSPNNDRGLGNGTFNTDIGRAPLDNRPGSQGNKGPSPIAPPNNQRQSSQARPQPPAPIGSGPSRYGSSGPHPPAGSDVASKWITAVGEKDKQLSASRLAERVERDRLLAERGVSLEDAQPVIKDTWRQVHAPGDGTRRAIGPQEAQPAGPWRSHDDDAKEDPTNVGVVGSGVPGQAGASQNRTSRFFPMRDSHDRTNENEPSRSKSPTPPPPTMEGHPAYEGDVMKPHVSLPKPHPVVKLPPSMMASQPSSNRGQFGWAHPPSFKDVVRGPVSPNRVPLTAGESSQEKWQNKINSLLGNSSRSPPQRSIGVDPASKSALDHVAHHDSATVSLPRNNVSAPAHFDQGLSSPVTKPMAEECFEEQEMGSLPQIRLPHKAPEAAWQPALAPNKPLPKKFAIQPTVMEPYYFSAEVVGGGNVMRIMFPNMQEARTVTIPFSATRGGRGSQGRGGPRSRGSGYERRGGKRDVSSSRGEHPPTSSGRGGRGSYRGRGSDWGRTPSNPASLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3Q1</accession>
    <name>S0E3Q1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_05346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431539.1">
        <property type="nucleotide sequence ID" value="XM_023578546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3Q1"/>
    <dbReference type="STRING" id="1279085.S0E3Q1"/>
    <dbReference type="GeneID" id="35398825"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05346"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT69459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="321" mass="34126" checksum="2693B93D131675B9" modified="2013-09-18" version="1">MSTANTTFDALVIGGGPAGLSVATGLVRQVYKVAVFDSGVYRNAASNHMHNFAAWDHKSPAEFRSKARQDLLDRYADLFQFVDKQVDVARKTDSGFELVDADGTTWTGKKLFLATGWKDLFPDIPGYSECWARGIFHCLFCHGYEDRGKPSAGVLGMNFSGSSPMALHLARMVLRLSNKAVIYTNGGDSLGEQIKSDLTATGTDGAKSRITVDNRKIVGLSMKSTDSSDIVIKFEDGSEVVEGFLAHGPMGQINGPFAEQLGLELTPTGDIKTEGQMFETQVKGAFAVGDCATMMKAVSQAVGMGCLAAGAAAAQLGAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3Z2</accession>
    <name>S0E3Z2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_13654</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429524.1">
        <property type="nucleotide sequence ID" value="XM_023576364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3Z2"/>
    <dbReference type="STRING" id="1279085.S0E3Z2"/>
    <dbReference type="GeneID" id="35407108"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13654"/>
    <dbReference type="HOGENOM" id="CLU_021259_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="113"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT67443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="449" mass="50152" checksum="0CBB80AFE7263148" modified="2013-09-18" version="1">MENAMANVDLGRYRRIVQMFWDPEPTNDVAHDHPVWCLGRSYKLSDKKNTKSDEQNPQTPPPAPKSDTEDQDTTRSPNIPTNAPETPPESISSSFSSSLAYDDQSNDGGWPSGFITDFESRIWMTYRSEFEPIPRSTNPEATSSLSLSMRLKSQLGDQSPFSSDSGWGCMIRSGQSLLANTIALVRLGRDWRQGQSLEEECRILKDFADDPRAPYSIHSFVRHGASACGKYPGEWFGPSATARCIQALANSHEPSIRVYSTGDGPDVYEDDFMKIAKPSGEAFHPTLVLIGTRLGLDKITPVYWEALIAALQMPQSVGIAGGRPSSSHYFIGSQGSFLFYLDPHHTRPALPYHENPMDYTREEIESCHTARLRRIHVREMDPSMLIGFLIRSEEDWKDWKRSVKHVQGKSIIHVAQQNAVHGGSSEGREGAIDEVETLSDDDTDTIQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4D1</accession>
    <name>S0E4D1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431671.1">
        <property type="nucleotide sequence ID" value="XM_023578705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4D1"/>
    <dbReference type="STRING" id="1279085.S0E4D1"/>
    <dbReference type="GeneID" id="35398968"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05489"/>
    <dbReference type="HOGENOM" id="CLU_040048_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="71"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="379" mass="43257" checksum="4133F2CCF64ECAC2" modified="2013-09-18" version="1">MASISAPNTNSVPGPSSIPQDIIATRSQILSTCFYKRTKYYFPHHDSQVEQFSKDVYRLFSHCYKTEVPNLGILARLPQDILEGILLQLDIDSFRRFRQVSRRARYLATALLFYQRVLRHAPDALNALRRTDLSGYVSYSDVYTALMTTKCTFCGQFGDFLFLPTAERCCFQCLRTSPETALVNPARISRRQPWKGLYTDHADVITNTVESMGVRSFKTHNWDDVQKMSKTRGVLAKDLLAAYIKVDSTLEEPGRALLNPGWLHYRLAASIIFPCLSLRRGKVKTGVSCIGCHRKIWSQNDASLISVSNANISSNPCFRARDRSYSEDEAVSHFSRCAESQRVWWASGRNSVRCMFIQQGGIHYYKANKWRRDEENLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4M8</accession>
    <name>S0E4M8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_05758</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431919.1">
        <property type="nucleotide sequence ID" value="XM_023579007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4M8"/>
    <dbReference type="GeneID" id="35399237"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05758"/>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="63"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT69839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="530" mass="59890" checksum="BA59BF613F74185C" modified="2013-09-18" version="1">MAEAKQTSAVAVDDRRDDRDTDNSATEYEESEKSGKSWKSYVWDTWELPKEQRWLLFKVDAFVLTFASIGYFLKNIDQTNVNNAFLSGMKEELNMYGNELVTSTSIWTVGYVVGQIPSNLLLTRVSPRWVIPSLEVGWGIATICTSAVHSYKALYALRFLVGLFESGFYPGIHYMLGSWYTPREIGKRAMIFWLAGSIGNMFSGFLQAAAYTNLNGVHGHAGWRWLFIIDGIITLPLAVAGYFFFPNLPQDGVKTWWTTEREHEISIERMNAIGRAGKEKWTKAKLKSILLSWHTYFLPMIYVLWNNAYPQQAMGYWLKSFNADPPPVPGTSYSVAQINNLPLPSTAIFIVMALFWGWLSDGPLKGLRWPFIYAGAIIAMAFNIALLKMPLYGNNRDRTLVYWFANIGNGAGPLILSWINEICSADAEKRALLVAAANDFAYVVQAVAPNFVWKTTDFPRAAKGYTWSTVLNALLIVWTAIVQLLLAWDRKRQAKARQVMSEDSEANSQEEFHDDGKTLEYPVEKKGAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4T1</accession>
    <name>S0E4T1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to phospholipid-translocating ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_05810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431969.1">
        <property type="nucleotide sequence ID" value="XM_023579065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4T1"/>
    <dbReference type="STRING" id="1279085.S0E4T1"/>
    <dbReference type="GeneID" id="35399289"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05810"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="301" mass="33388" checksum="97A2B244192F3DEF" modified="2013-09-18" version="1">MSHTPLPGGLISFGSDANCTLELCPLESSILRYQPNVPANAIFIGVFGLSMALHIFQGIKMKTWGFMASMMAGCILEIIGYIGRLIIHDNPFDFIGFLLQIIMITIAPVFFSAAIYVLLSQVINFVDPSVSRFSPKYFYWIFIPSDIISLILQAVGGAVSVVSTAQEDVKTGEDVSIAGLVFQVVTLLCFVALFIDYVIRASKSPARYRLTKPILTFLFFLFLSTIFILIRCGYRIAELNGGYFSAIFRDEGLYIALESCMMCIAVLLLNAGHPGYAFKETPEFTKEMDQMDQDDNTVFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4Z9</accession>
    <name>S0E4Z9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to multidrug resistance protein fnx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_14693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429784.1">
        <property type="nucleotide sequence ID" value="XM_023576655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4Z9"/>
    <dbReference type="GeneID" id="35408073"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14693"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="49"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT67703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="542" mass="57768" checksum="8CA0D7742A40AE32" modified="2013-09-18" version="1">MSERTPLIGSDHENQSYGCSPRDVAETSEQDGEVAIICKELSFARLAMIMSTAWLGVFLGAADTTVIATLSAQISSEFNSLSLLSWLATAYLIANAASQPISGRLTDIFGRGPGLAFSNIAFAVGNLICGLATSQKIMILGRVISGIGGGGLMSIPTFLGSDLVPLRKRGLVGGIANIWYASGAMVGAVFGGFLNDYTSWGWRMAFLIQVLPSLLSAIIVYSLIKVPPKQSDKSYVKRIDFGGVFLVSSFLAALVLGLSSGGNIVPWLHPLPIAAISLSILLFLAFVIWELRASQPIIPVRLLLNPTVLASCLASVFCSAIALTSIFYVPLYLQARGDSATNAGLKILPASVGTCLGGLVPGYLMKKTGKYVGLVVSSILLLVTGTGIFAFHNETTPAWMTCLAFFIVGLGYNAVFSITQVACVAAVGHAQQAVVTSTTYLARSLGGTIGITLASVLYQSSLDMSLQARFGHQPNAVEEIRRIKDDLTEIRRLPEGWYSGVIESLMQAFGHVWLMMLAWAVLALISISPIKQHKLFSTLDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E540</accession>
    <name>S0E540_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429814.1">
        <property type="nucleotide sequence ID" value="XM_023576704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E540"/>
    <dbReference type="STRING" id="1279085.S0E540"/>
    <dbReference type="GeneID" id="35408117"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14737"/>
    <dbReference type="HOGENOM" id="CLU_002639_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="127"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="595" mass="66386" checksum="91DDCB947CCBB530" modified="2013-09-18" version="1">MPEVLYESILVESKPPKHPGPMVVHLYPEPVAHAVSEKTFQLYTTENDVSLPWDLIGRGYHIPEYGLAPSCVSLAREWLDACGHAQGKHANCTKTTISTLPTRVISVGNDKVSPRLVVTEPNQQAHYAALSHCWGGKTPTMTTVSNLEAYTISLPNDLPRTFLDALKVARALEIPYIWIDSLCIIQDSPEDWKHEASRMAQVYANAHVTIFADAAPDSTSGFLSPPSRNAPKRFVVPYRNDQSSSGVVHIRERGFLAQQLPYHTWSSRRSGLGQSKLSTRGWVFQERLLSPRTLHFSRNEMAWECRSVCECECSATSLRTLRTTSVMKHFLHPQDPDVSLAEANWRSEIVPAYTELDLTFATDRLPAIQGLANATQRLRGNDEYIAGLWRKTIKADLLWHRNAGDGNAQRIKDGGAPTWSWGFVTGPIYYSDRILPSDSDLQILDIMTSEEKSPILVIRGHLVNVKLEDPYSDTVSLGPDDSLRVEWDSEGLQTESNKISPYFLVFEADDGGPFGLLLNADRNDPTGQQFRRIGYIHGHSISKWRRSWGSGGWASSPDSSASDTSGGIWEDAGKEGAREWVDEIFKGEPVTFKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E575</accession>
    <name>S0E575_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_05840</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431996.1">
        <property type="nucleotide sequence ID" value="XM_023579098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E575"/>
    <dbReference type="STRING" id="1279085.S0E575"/>
    <dbReference type="GeneID" id="35399319"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05840"/>
    <dbReference type="HOGENOM" id="CLU_022477_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="14">
        <location>
            <begin position="38"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT69916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="503" mass="55446" checksum="B23852B017B3391A" modified="2013-09-18" version="1">MMNLRLLRQQCLRTKPSLASRVTTRTFASQSDLLGANLEQGDPEIHAILKREEKRQNHFINLIPSENFTSRSVLDALGSVMQNKYSEGYPGARYYGGNEHIDEAERLCQRRALETFRLDPEKWGVNVQPLSGSPANLYAYSAILNTHDRIMGLDLPHGGHLSHGYQIPNKKISMVSKYYETFPYRLNEETGLIDYDKLRENALLYRPKVIVAGTSAYSRLIDYERMRAIADEAGAYLLSDMAHVSGLVAAGVIGTPFEDSDIVTTTTHKSLRGPRGAMIFYRKGVRSTDKKGKQIMYDLEGPINASVFPGHQGGPHNHTITALAVALRQAQTPEFKQYQEKVLENSQALAKQLSEGLGYKLVSGGTDNHLVLVDLKPKGVDGARVERVLELVGVASNKNTVPGDRSALKPGGLRLGTPAMTTRGFNGEDFKRVADIVDRGVQITLAVDKDARAAAEAKGAKNPGTVKNFLEFLGDGSNVKEIKALRDEVAEWVGGFPQPWLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5N2</accession>
    <name>S0E5N2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429984.1">
        <property type="nucleotide sequence ID" value="XM_023576792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5N2"/>
    <dbReference type="GeneID" id="35408185"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14806"/>
    <dbReference type="HOGENOM" id="CLU_1402542_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="194" mass="21278" checksum="CC8E79D7C9962E38" modified="2013-09-18" version="1">MDCLCGAGQRRTHRRIFSHRCCYEHCDGIFLTLDGSVSDCENHWAPWQGLTWLNASMPLCCDTGNGAPGLEGSLAPHMDLTIVIILYTPTNPTQPALPHGLARVDAQTGRSLHPRVSVPIPATNNLVAIHILESDMTTARGGLKASSWATPSCQAVPSSITRTMPWLPNLMLQYDLLALHLVFLLQKIFSYGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5U9</accession>
    <name>S0E5U9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable oxidoreductase, short chain dehydrogenase/reductase family superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432363.1">
        <property type="nucleotide sequence ID" value="XM_023579545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5U9"/>
    <dbReference type="GeneID" id="35399719"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06242"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF2">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G13450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="258" mass="27695" checksum="BB7B233D2570FEC7" modified="2013-09-18" version="1">MAVILIVGATRGLGASLTKKYAEKSENTVYGTTRSSEGPKDSPSGVKWLSDIDLIQSNAGQKLASLLDPAQPIDSVIITAGYFATEDLTLDKGPKWEEEQRMYTTSSIAPVFIVHQLVHKGLLRKGSKVVLVSSESGSITLRHPKEGGGNYAHHASKAALNMVGKLLSLDLKDQGVIVSIVHPGFMRTEMTKGVGFDKFWDDGGAVTPDKAAASLISWIDSLDISKTGEYWAPRGPRDIGTAEVVLGEDLATPLHLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6K5</accession>
    <name>S0E6K5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432588.1">
        <property type="nucleotide sequence ID" value="XM_023579819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6K5"/>
    <dbReference type="STRING" id="1279085.S0E6K5"/>
    <dbReference type="GeneID" id="35399965"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06488"/>
    <dbReference type="HOGENOM" id="CLU_1042246_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="267" mass="30438" checksum="353FC9D79DE58377" modified="2013-09-18" version="1">MSDFNQAVTSAQLRGARLVALFNDPDVVYKASEEEMLKRPSPDQRSGLNRWREAEMRTVWNNFWTQLLNPYPMDPTIFLPSSASLPWSFQDVLWYLFQIYDSKSSGLNSDAVFASEHSSTQYGALGPKLERKNCFNGSESSKNTGQGDNLVPWTSSLMNTIQRAIWRSHVGHKPASNVYICAVNTRKVPQGQFARDMWLLDTSAYPRSNWLRLENPEYDNREYLSQGVIHHGGRSSTFSLQDLVSSGLYKEYPEQSSTLKVFGRIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E894</accession>
    <name>S0E894_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433160.1">
        <property type="nucleotide sequence ID" value="XM_023580375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E894"/>
    <dbReference type="GeneID" id="35402351"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08876"/>
    <dbReference type="HOGENOM" id="CLU_021768_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="296" mass="33903" checksum="742E2AC13550407E" modified="2013-09-18" version="1">MSSTTKAEQDEQIDSEPEKEDITDGKLPKYLKCSYLDAVVGKEIHNYWGNRVLEHTNSHGEVLALKVSNPDGIDRAQADMMHYAATHGVLAPKVRGVYDVITRRPIARVMISERVPGVPLVDVWQNMSQAEQASIKEQLRAQIKQMRTLIQPYIGRIDKQPTRNIYNTTFVRHCGPFEDEESFDEWCLARLPGGSFQRWKWKRVLEKQRRKSTGRFVLTHGDLSPRNIMVDGSTITGIIDWELSGFYPEYVEYAVAMGLGPGIEEWWVPVLKEVLEPCSTDLVKFTELIEERMGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E974</accession>
    <name>S0E974_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433284.1">
        <property type="nucleotide sequence ID" value="XM_023580520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E974"/>
    <dbReference type="STRING" id="1279085.S0E974"/>
    <dbReference type="GeneID" id="35402220"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08744"/>
    <dbReference type="HOGENOM" id="CLU_2454902_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484978" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="89" mass="9226" checksum="BF3B91937546C152" modified="2013-09-18" version="1">MFFKAIITASAIVGLAAAGPFRTNTTTSACPTLCVDAINDCGVMYGACYPVCSPELYPTPPPCTRSTPITTPTISLITPTPDPITNSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9N1</accession>
    <name>S0E9N1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_14324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431263.1">
        <property type="nucleotide sequence ID" value="XM_023578457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9N1"/>
    <dbReference type="STRING" id="1279085.S0E9N1"/>
    <dbReference type="GeneID" id="35407776"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14324"/>
    <dbReference type="HOGENOM" id="CLU_013387_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014390">
        <property type="entry name" value="Acid_Pase_Asper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000900">
        <property type="entry name" value="Acid_Ptase_Asper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005146081" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="8">
        <location>
            <begin position="71"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="276"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="7">
        <location>
            <begin position="533"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT69183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="651" mass="70133" checksum="2114F71D2D1B49E3" modified="2013-09-18" version="1">MKSLAAPSLLAAFLTTPALSKPVVDEKYPYKGPAVPVGDWVDPTVNGNGKGFPRLVEPPAVKPGSSNPSNNVNVISTSYTPGGINIHFQTPFGLGAAPAVHWGTSASELKNKATGSTTTYDRTPPCSAVKAVTQCNQFFHDVQISDLKPGKTYYYQIPAANGTTKSDVLSFTTAREAGDKSEFTIAVLNDMGYTNAAGTYKYLNKAVSDGAAFAWHGGDLSYADDWFSGILPCEDDWPVCYNGTSTSLPGGGPIPDDYKTPLPEGEVANQGSPRGGDMSVLYESNWDLWQQWLNSITLKIPYMVLPGNHETTCAEFDGGNNTLSAYLDNDKSNATQANMTLNYYSCPPSQRNFTAFQNRFHMAGDKSGGVGNFWYSFDYGLAHFVSINTETDYANSPEKPFATDLKGDETHPKANETYVTDAGPFGAVHGSYNDTKNYEQYQWLAKDLESVDRCKTPWVIVMGHRPMYSSEVAKYQVNLRAAFEDLMLKNNVDVYIAGHIHWYERLQPMGHNGTLDSGSIINNNTYKSNPGKSMVHLVNGAAGNIESHSVLDGEPRLNMTMFLDQTHFGFAKLTVHNETALSWNFIHGDGGVVGDELTVLKESASKCAASGNSSSSGGASGTKAPVATPTSAGTKTFVSGVLGLLVLALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAK5</accession>
    <name>S0EAK5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434019.1">
        <property type="nucleotide sequence ID" value="XM_023581302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAK5"/>
    <dbReference type="STRING" id="1279085.S0EAK5"/>
    <dbReference type="GeneID" id="35407520"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14066"/>
    <dbReference type="HOGENOM" id="CLU_018104_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="547" mass="61778" checksum="0C5FE35505BF2140" modified="2013-09-18" version="1">MADTSDKAPFSPGARPLSPRVVTRQACDNCRIRKRKCSFGSDKGIRWATVPCAPKPGTRCRNCIKADSQCTFLLPSKARGPKTRRNLHHNAAQHSVSPENSLNLDSELVNQLSPFTTESSPSTGITAYATDILFPRELVRFILSDYVTYVYPLIPVIHQPTFQLDFDSDRDMHDVDFLALIISLCAVTVSLLPSRFKTYRSFSSPLPFETRTEMADQCHKLNQSFRDTTYFDTVSHQKWASTFLLGVAFHQTVNNNLWRMLEVESMQLLRLLEVQHLSSYSGLDAVEIQLRKKAFWLMFYGYVHQMYNLRNERLMFLDPATLSDLDIEGLMPYAVDDEFISCTGVLTCPEDVSSKSLTAGFNIHSRVFAAAVISPRLTTHPAPDLCHPKDPVSRLDSLKNRLHHLKYMLDTIVPAYRPWLPRTHNPDPEGGTDVVNVQREAIRVNIHVTHLWLQSVLLDQIDLLAGEKHLSSLVTPSLVTSSLTPTSRLQILNPVLWDEREHICRQLLHFLHSMSHSGLESNGISLVSIFISPQLSQTSQESAAQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB84</accession>
    <name>S0EB84_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to cytochrome P450 7B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434217.1">
        <property type="nucleotide sequence ID" value="XM_023581532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB84"/>
    <dbReference type="STRING" id="1279085.S0EB84"/>
    <dbReference type="GeneID" id="35407314"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13860"/>
    <dbReference type="HOGENOM" id="CLU_018012_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT72139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="550" mass="62693" checksum="A9534400263CFF05" modified="2013-09-18" version="1">MPSLRMPSRVLKDMFDFDMMNAPLFNVSASSIALVAVLLLLSTHCITTIRYSIQRFYDRRYKGKEPSTLPYVLPGVGSALSLIRNPHGFFNSIVQKVDNGEPIRMRLGNVHAYLIHGTRNVQQVFRCSKELTFEEFALRVAQKVKRLPAKDAALVAKDISGSSRLPLTETREEDRIWRRFHEIYESHLIGANAVSALTELFINTMIDELSTVGTQGPIEIGIDEFMKHHMFRASTIALAGRKVFDIDPNFADVFWDYDEDFMSLLYGIPKFLCRKGSNARDKCLETVKGYLDQGWQNLDWRACHEKNPDWESNFGSKLVREREVAMEKYGIGLDGRASFQMGLIWSINSNAIPMTSWIIIEILRRPEIFKQIREEVPAVFDKDTKQVDIVALKKLPLLNSVYFECLRLRSSVFVVRKLRNSIELDGYTLKEGNLVLAPSYLAHNAPEVWSSSTHPPEEFWPERFIRKGNSGISAGNYFPYGGGAAMCPGRNYAKQEILSAVVLFFAHFEIEPLRFVDRDGKTSDRGPEVGHEARGVARVDRDLLVKLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBF5</accession>
    <name>S0EBF5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_08888</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433151.1">
        <property type="nucleotide sequence ID" value="XM_023580361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBF5"/>
    <dbReference type="STRING" id="1279085.S0EBF5"/>
    <dbReference type="GeneID" id="35402363"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08888"/>
    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF5">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="16">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="15">
        <location>
            <begin position="117"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT71072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="412" mass="44394" checksum="DDF0255A949C53C5" modified="2013-09-18" version="1">MAATDFAHHFTEKNIPFGIASSESHNTPQAVTRLGNTVIFLSDLVEQLFKDVEGLSRGVFNEETLNSFAALPKTVHQNVRKQIQQAHRHKGLDGFPTSSKEDITAVTMHLPVEIKDFADFSCSLDHVINAGRIVVNNGTPPPGFFKFPVGYQGRTGSIVVSGTDIERPYGQFKNPAAAEGDDPITYAPSQKVDYEVELAAVVGKPLAMRQRLHAKDAEEHIFGFVILNDWSARDIQGFEMFPLGPFNGKSLGTSISPWIITLDALEPFRTKAQEQKAISASYLQHPSPSTFSITLKVDVLANNTTTTLGVCPVESLYWTPQQMVAHSVSSGSALRTGDLLATGTVSGSEETSRGCMLESTEGGTKPVTLSDGSKRGFLEDGDVVRITGSVGGDESGVGFGECIGKLTPARSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED28</accession>
    <name>S0ED28_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434867.1">
        <property type="nucleotide sequence ID" value="XM_023582317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED28"/>
    <dbReference type="STRING" id="1279085.S0ED28"/>
    <dbReference type="GeneID" id="35406138"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12682"/>
    <dbReference type="HOGENOM" id="CLU_924480_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="116"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="372" mass="41613" checksum="BAA308A8EB1B0E53" modified="2013-09-18" version="1">MTDYNTMFEDTRLTAYLILLKYYVIPRTRLRALISRILGKQEPTLQHMLANATIRWLSSKLSIHQFRALSSGQCNAIALLQNCPTLLEEKATAETIVGDDYRGHYLAKYPNPTYIIFYVYGGGFVSGSPGSVMPYLLQLSVELQARGLKADMFVAEYDLAPEYPYPGALRQVVSAYRYIASRNLPIILAGDSAGGNLCLGLLRHLIKPHPSIPPIVQAQGETGSIAATCLNSPWVNLQNNGESYRQNANQDCLDKGALDRWRKAYLDGKPLDEYVNPIDCLNGWKEILPKNTLFIAGDLELFVADIQKLAQNQSGYNDLEMHVEPKKGHVWSLVDFGSTQPGLPAARHEQEEDHVYSGIHLQADWIAEKCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDD8</accession>
    <name>S0EDD8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435024.1">
        <property type="nucleotide sequence ID" value="XM_023582498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDD8"/>
    <dbReference type="STRING" id="1279085.S0EDD8"/>
    <dbReference type="GeneID" id="35406300"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12844"/>
    <dbReference type="HOGENOM" id="CLU_051290_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="298" mass="33600" checksum="A72FE5338D2AF210" modified="2013-09-18" version="1">MSRPASLNPYDKIIDSLAGNPTRIQALFEEERNDRNNEAKEKLLGEEFQGVNVDEILVNTLKNPKYQDPRNCLCIWARPSFQVKDIALQCQLMLKRLSPNLWLTPQDCLHMTVIVVALSITPKELVDKTIKFKPCLKKLASIFHGQQIRLVKPKLSFNEGGVALSFVPAADEETQDSRTKTTDYTYLHLRRDIFALCSEKGVDAETQKGATACHITLARFITQEDHSRNGNPSQEAMAFWVTGIEEINEMLAQKYWPHEGSVPPDSGSWVIDGRRSLDIRAGTIWYGGGQSLDLESEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDF3</accession>
    <name>S0EDF3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434728.1">
        <property type="nucleotide sequence ID" value="XM_023582152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDF3"/>
    <dbReference type="STRING" id="1279085.S0EDF3"/>
    <dbReference type="GeneID" id="35405990"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12534"/>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="265" mass="29937" checksum="330FC0B7F1A71F67" modified="2013-09-18" version="1">MGQSSSKQATSEQYLAKPSGSCCLKGTIHEGESRGTWETIADVETYISKPAPEKANGNILLYFPDVWGMFSNGLLVMDAFADAGYLVLGLDYFRGDPVWKHRKDRHTQNPDFDYEAWKRKHTAFADVAVPKWVAAVKKSYGTNTTKFACVGYCFGAPYVCNELKGDTVTVGAFAHPAFLKEHHFTDLKKPLFLSCSEVDHTFDVPSRRRALDILQTNKKVFHYQVFSGVEHGFALRGDPKDPYQRWVKEQSLAGIVAWFNYWLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE39</accession>
    <name>S0EE39_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to ribose-5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434175.1">
        <property type="nucleotide sequence ID" value="XM_023581482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EE39"/>
    <dbReference type="STRING" id="1279085.S0EE39"/>
    <dbReference type="GeneID" id="35407359"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13905"/>
    <dbReference type="HOGENOM" id="CLU_091396_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="164" mass="17325" checksum="E155F2936FA476F6" modified="2013-09-18" version="1">MPSGLRIVIGGDDAGFPYKSIITQQLLTDPRVSSVVDAGPSSEEDKTAYSHFAIAAAEKVAKGEADRALLICGTGLGVAIAANKVRGIRAVTAHDSFSVERSVLSNNAQVLCLGQRVVGIELAKRLVKEWLGYQFDPNSSSAAKVKIIEDYDKEQLIAAPVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEY9</accession>
    <name>S0EEY9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435407.1">
        <property type="nucleotide sequence ID" value="XM_023568051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEY9"/>
    <dbReference type="GeneID" id="35403452"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09985"/>
    <dbReference type="HOGENOM" id="CLU_013296_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="234"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="564" mass="63237" checksum="3FE74855F7926F83" modified="2013-09-18" version="1">METPVPTPPFFGRAGHNEIFEEAKNCLSQLDSSDLDSQEACTPCSHSNKPIRFQELPPSIKQSCLALLGCVFGPSYEHMISQGTKNENRLWSNLTVPAVINSLEATFGTKLERRKLNLELIAQQICNNTAQPFQDIDTSSQEWVNQLCGPNLRWESIGLLWSVLRRIPGSFDPIEKNQFHVLESGTANKPVLAFLRHSINLARHFTLANVIILDLLFQKAIMESMVVGDASLICWSSFADAVSVMTYLGVHAEKLTGHYRPSLSSEHKRRLFGRVYNLDKAIVAFTGRPPLLNPRFCSTPPPLDLSDEDLLAGGAALERVVSELDSRGWNLRGGVYPSSICRAGYLMAQILNEIIDISLASGANATVETIRNLKQRQLNIFAELPRCLVYDPDDPTDLPLPKAEIRSYDKDLSDPPVEANVVSLKIFIRLTHLQNMFLLERLLLQYGCPDEGDVLLVSYEMITLTLMFWMHKDRFRDIRRDMEWLLMAFAVPGGGILCLELLSPTFQGKHPKDSRLSRSSIVQQLSLLVGFLDWVHPSAPNGDLCASCKTVIQLQFWFNGEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFE7</accession>
    <name>S0EFE7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433162.1">
        <property type="nucleotide sequence ID" value="XM_023580377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFE7"/>
    <dbReference type="GeneID" id="35402349"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08874"/>
    <dbReference type="HOGENOM" id="CLU_794632_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39958" checksum="BE95AC2888A93DFF" modified="2013-09-18" version="1">MAEILGVAASATQLGVACFSLIDVMRKIKGGASTLKRYHEQLQELQSISTSISENPLLQTPEIGTQTDALLFIINNNCLNSLLRKGRVLRTWGFLYREQDLLDIFVRLERQKSNLSLAIEQIQSKALYQIQTDIQIMSEKRPLNYSCSQSSSETIAGPLVSRESTETTHPPSVPRIPPDLESLYLYDRYERSFLSLTMATNPFPNQHPYSHTKASTGSPDDQSASQPEQPSDHTDRYSMGTHYINAVAGPGHDQFNGDLFKGDGKLSQEIQKNRPVRSNTTPTFHKGPRKYGAGNQYNGGKYVFEGDPTGATVPDMNGYVFMNPSTAPYPSADPGDVRYGAQYNGHVISQKGVEDQEKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EG11</accession>
    <name>S0EG11_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">beta-glucosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_09224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 10"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436019.1">
        <property type="nucleotide sequence ID" value="XM_023568899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EG11"/>
    <dbReference type="STRING" id="1279085.S0EG11"/>
    <dbReference type="GeneID" id="35402693"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09224"/>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="389"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT73941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="811" mass="88849" checksum="CC161EB945EEA877" modified="2013-09-18" version="1">MDIHATLKTLSLQEKVRLLSGTPDDFVSIAGIPEKVIAPFKTADSINGIRPSEFNSTLTTACFPNTACIASTWNTELLEKMGAELTRQAKIKHAQMILGPTINIQRDPRAGRNFECFSEDPLLSGYMAAAIVNGIQSKGYGACAKHFVCNDSETQRRYYNVDESPNGRALREIYLAAWSFLLKKYNKVDGSFCCDSKTLIEDILRKEWGYKGIVMSDWFGTRSTVASMKAGVDVEMPVPVFRGERLIKAVGSGEISEEVINASVTRLLDLRNRTQAAQSEGPEKSEIIKETNDIARQLAQEGIVLLKNEKQTLPLPASSGLRIGVVGEYAKKAVFTGGGSASCNPQYRQVPLDLLREALPDENIVSYSSGVRMRRIIPTVPVDIATTDKGKKGVEVAYYNAGEDEPVLTETLQDAAINLMAQGKPGLKTPGSRVKMTTNLVPTTTGTHTLALRHSGSFNLEVDGVSVFKGDAPDITTEQFLFNLIKLESRVELQMEAGKSYHISVTMQSREPVVGEPTPYGLTMAFEEEYSEEQAISDAVEVAKSSDITIIHAGRSEQYESEGFDLEEITLPANQVAMIRAVAAASKKTAVLLHCGNPIYISSFVDDVDAIVNMHFPGQEGPQAMVDILTGKVNPSGRLTATWFKTLEDWPSFGNFPAQKYEAGDFTIKYAEGLEIGYRARVSENRVQFPFGHGLSYTSFSYDSLQAKLDASSTPSTLTVSVNVSNTGSLSGKEVVQVYISAPKNGAHWRPTRELKGFTKVQLSPGETKEVSMQIEVDTFNSHWSEDSHAWVEDKGEYGVEVGDQRVTVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGB9</accession>
    <name>S0EGB9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable Protein GET1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GET1</name>
        <name evidence="11" type="ORF">FFUJ_09863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGB9"/>
    <dbReference type="STRING" id="1279085.S0EGB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09863"/>
    <dbReference type="HOGENOM" id="CLU_089418_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000006">
        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT74031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="207" mass="23301" checksum="C56C20A25D3C8DA9" modified="2013-09-18" version="1">MASLMLSIFVVEVVVNLVNTIGAAAINNLLWTIINFLPVSTAKAAGEQRKLQTDYLKVRRDLNSTSSQDEFAKWAKLRRQHDKLLEQLEKTKKTNEAARSNFDKILTVLRVVVTRAPQYFLPFWYATEPMFWLPYGWFPYWAEWILSFPRAPIGSVSIASWQLACTGVIALFSDLIVGIAGLLLNAKQAKEAPVAAQKVAAEEKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH75</accession>
    <name>S0EH75_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ceramidase</fullName>
            <ecNumber evidence="1">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.23" evidence="1"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435270.1">
        <property type="nucleotide sequence ID" value="XM_023567892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH75"/>
    <dbReference type="STRING" id="1279085.S0EH75"/>
    <dbReference type="GeneID" id="35403596"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10130"/>
    <dbReference type="HOGENOM" id="CLU_051035_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029130">
        <property type="entry name" value="Acid_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF1">
        <property type="entry name" value="ACID CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15508">
        <property type="entry name" value="NAAA-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acid ceramidase N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="412" mass="46706" checksum="FBDD16EACA1FE9B6" modified="2013-09-18" version="1">MSEHREIPKFTVDLSLPPETRYGHIVPHFKTAVDSCDLPSLFYALLNELAGESAGKIIAAVSPLLMRRLHSDEENAELVGISKAIGIPMHILVAFNVLLDLLLGCTSGGVRTLDPDSAVKTTRMLHFRTLDWGMHELRNIIVELDFVRTPQGPVIATTVGYLGYIGALTGVRKGMSLSLNFRPHHARETLRQRLSYRYHQVMVVLGQRQSISSSLREILLDNSTTLGKQSNEAHELDNISPDLQNQYVQQVLTKLSISSSTAAYLILCQPDRVLVVEKDHRSASIRESDTFLTAYNHDFKDEDNPAHLQQAAAELAEGEDATGMADLVAYSIERKQDLDKLWRKCVRACKRRYRLRNDIVTREDVVKFLQNDMIRNEETHYAVIMDPKEGKVMWRRAYEYVSESERESTEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHB5</accession>
    <name>S0EHB5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436489.1">
        <property type="nucleotide sequence ID" value="XM_023569247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHB5"/>
    <dbReference type="GeneID" id="35403925"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10460"/>
    <dbReference type="HOGENOM" id="CLU_1917228_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="132" mass="15749" checksum="2797D0BF8ED33A41" modified="2013-09-18" version="1">MHATQTRDFNTWLCLVEVRTKDIHGTLNNLRQGPPRPLSEEEISRLMFILGHVFHATEMAQKLVDEHDEDQKRDLQAVCQEAKEFMIAVDCMQIAIWRLNPDRLCLSHKGRVRYNPYEEPIDKRRDSNWWYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHW3</accession>
    <name>S0EHW3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436323.1">
        <property type="nucleotide sequence ID" value="XM_023569054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHW3"/>
    <dbReference type="STRING" id="1279085.S0EHW3"/>
    <dbReference type="GeneID" id="35403753"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10288"/>
    <dbReference type="HOGENOM" id="CLU_1086046_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="256" mass="29385" checksum="561C13A0870941A7" modified="2013-09-18" version="1">MLTCRPAEHPVDKSVMKAFYVDAARGRLASGGQASSGPIPLIFFENMPGIGELDRYRNGFTLISGNANLGDSNLFNRIMECLGSREHTDPFIVTEETLNWVKGELMQHNQPMNYKDRLDTMETNPLYALGILRASIATFDYMNTRSGPDVYGKTTNVLQDIYNQLISAQAMWELENPNEPVNIVQFFIEWFPDWYQTALVKARDFVRISIAEMRNIWEHKSGDDETRNIVLETLDSLEPRIIRMHIDTDWPIQFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHZ8</accession>
    <name>S0EHZ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_10674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436694.1">
        <property type="nucleotide sequence ID" value="XM_023569484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHZ8"/>
    <dbReference type="GeneID" id="35404138"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10674"/>
    <dbReference type="HOGENOM" id="CLU_028200_6_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485951" evidence="8">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="9">
        <location>
            <begin position="94"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT74616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="409" mass="45605" checksum="B98291E084C0EFD2" modified="2013-09-18" version="1">MRLLSFSFFLAALLGLVNAASFTELAAQLPDCDVNQTFAGLTQACVLKNCTVKDSLTLMRVQNLACGVPVKSQQMKFRLNALVACILAEICVILRIYSKLKIFGKLGPDDYAILIAGFATVPYIWLACRLADLGFGLNIWDITPFERLYELLKLFWIDQIMYSVHLYSTKISILFFLRGIFTTSEFKKLTVSIGIFVCLCGAATMITTSLQCLPASYNWTSWDAEHKGHCNDLNSQTYAFGGINMACDIVILVLPINHLWKLQVKGRQKIQLFVMFSLGIVVTVFSIIRLPFLITLGKTTNPTWEYVEVTIWSIWETELGMVCASLPAIRHLFKHLWPNAMATIASKMSFSSTNKDSTLDKSAGSWGGSRGTRSKTDNKEYYELDERSLIGKGPDPATNVSSTNVHSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIJ3</accession>
    <name>S0EIJ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435750.1">
        <property type="nucleotide sequence ID" value="XM_023568572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIJ3"/>
    <dbReference type="GeneID" id="35402984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09516"/>
    <dbReference type="HOGENOM" id="CLU_2454901_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="89" mass="10472" checksum="E0BED969DE11812C" modified="2013-09-18" version="1">MFWDAYTHNMPGAEWFGELSLWLLLFLALRYGLTIHRIPNPDRQRGVNVRRVDGGFQLDLMCRRPLSNDVAKHYPESHSLRFLFAPTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ75</accession>
    <name>S0EJ75_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434511.1">
        <property type="nucleotide sequence ID" value="XM_023581897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ75"/>
    <dbReference type="STRING" id="1279085.S0EJ75"/>
    <dbReference type="GeneID" id="35405762"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12306"/>
    <dbReference type="HOGENOM" id="CLU_000690_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000034">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF128">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT72433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="848" mass="98124" checksum="5226A99E28D547F4" modified="2013-09-18" version="1">MADHKKHESSGSMSSMLDKLKLSDGLHDAKVHLVHQKHKIGKLANLFNKNHRHDEEHEQRCDNKRTSIAEQNRFKSYFPMRAGNHVKWYVDGRDYFWAVSIALEQAKESIYIADWWLSPELFLRRPPYAAQEYRLDKLIKRKAEEGVQIYVCVYKEVEQALTCNSAHTKHALRRLCPKGSPGHGNIHVGRHPDHNVFENFGDMTWYWAHHEKFIVIDYEIAFVGGLDLCFGRWDNHQHPLSDIHPTNVQDEIWPGQDFNNNRVMDFQNVSSWQDNELSKADYGRMPWHDVAMCIQGPTVYDVAEHFILRWNFVKRDKYKRDERFDWLVLENRENEDEDLIGVQRPKHPVGEYVKHPYTPLSTKNLENRGTVNCQLVRSSADWSSGILTDHSIQNAYIEIISKAQHYVYIENQFFITATGDQQAPIKNTIGRAIVDAVVKAAKEGRKFRVIVLIPAIPGFAGDLREQAATGTRAIMDYQYKSICRGEHSIFGQCRAEDVDPEKYIFFFNLRSYDRLNKTPAIIKAEKETGISYQQVQRAEAEEIMGEGIHGSYDPEDSEGDEHMRGDKKQKDLDEDIKKTMEARKKFEAAMPKEEVHTTSSVAHHAMAGTGEGLKGESWFEGDPESEIKNWVQEELYIHGKLLLVDDRIAICGSSNLNDRSQLGDHDSELSVVMEDTRLIPSTMDGKPFEAGYHAATLRRYLWREHMGLLPPQPHDASQDINAMPPTVNPNNDIYDQDESYKFVEDPLSDELWEKWTSQADKNTELFRHLFHADPDDHIRTFDDYDRYLPPRGVKAGHIFDQFMPPEDAREKLSQIKGHLVWFPLRFLEDAEMAEWGLQVNSVTESIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJK2</accession>
    <name>S0EJK2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437047.1">
        <property type="nucleotide sequence ID" value="XM_023569895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJK2"/>
    <dbReference type="GeneID" id="35404507"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11043"/>
    <dbReference type="HOGENOM" id="CLU_153353_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="143" mass="15698" checksum="1B21FB4B55ACBBCF" modified="2013-09-18" version="1">MSKLVDDVKSGLKGIRGAGDALRGEVLDATDQAFDTNPQHPETVKDRVDNRAIAEKGKQDMHGADNMIARREWEHKGVEPPAHVGRRENEKPLVAQTEPPSRTAAHDRPNEGLSREPEMGHFGSRGTEGGVVKDPDAYLPRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK49</accession>
    <name>S0EK49_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to RNA EXonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_12660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434846.1">
        <property type="nucleotide sequence ID" value="XM_023582292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK49"/>
    <dbReference type="STRING" id="1279085.S0EK49"/>
    <dbReference type="GeneID" id="35406116"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12660"/>
    <dbReference type="HOGENOM" id="CLU_690879_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF114">
        <property type="entry name" value="EXONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="182"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT72768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="399" mass="45227" checksum="A47D5604A0A6906D" modified="2013-09-18" version="1">MASKATIVWKSSVDPELTWKGIWPMIDLWLRAYSSRQNLGGLPSGVNSPNCFAFSIPLPSLYKSTKTPQYQMFSSTKVLTQHNKAKHGKLPKTIPVQKQEIKVPIPQPLLEYHFKDPSYRRFPLLNMAVIHDRLILQCHSSQRLKKEGYNMGQENCNNGTKAAIRNKRIRAPNPDPLWPKRKAVALDCEMVWVRNGGREILSISVVDFFSGEVLVYSLVEPQEPIVDWRTHIHGIGPESLSMAMSQGRVLPGWAAARQQLFKHINTETVIVGQSLQHDLKWLRVSHVRIFDTAIVAAEAVSGTDFGFGRRWSLKSLCADLLKLRIRQGPEAHCALEDAMAAREVALWCICYPDKLKQWAKRAHKKSRTERPKEADHKKNGRRKVYHSHDGGEGNVGVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKF6</accession>
    <name>S0EKF6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437148.1">
        <property type="nucleotide sequence ID" value="XM_023570017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKF6"/>
    <dbReference type="GeneID" id="35404615"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11151"/>
    <dbReference type="HOGENOM" id="CLU_1749811_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496152" evidence="1">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="149" mass="15559" checksum="5BCB9534D618D094" modified="2013-09-18" version="1">MMYSLTVLIAACTALSAGSPTRPNSAGLQARDDLLGPATCPGGDKFALNEEDAAAGAEGFKLWVEQGADGKIDLSGNFKGQISKTHKGVTFFACDYKSGGKGSYINGNLVQSVLRKDGYLDSKCGSGRGGYESSNDLSIGRTFNGDHYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKT3</accession>
    <name>S0EKT3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Related to ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_11260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437293.1">
        <property type="nucleotide sequence ID" value="XM_023570137.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EKT3"/>
    <dbReference type="GeneID" id="35404722"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11260"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1118"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1147"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1189"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1222"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1254"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1377"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="85"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="779"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="733"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT75237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1412" mass="156404" checksum="17EA3BCFCEFA46AA" modified="2013-09-18" version="1">MSVNSSTTEDGSITATEQPPPALIDKPPLEKTNTTTQWHLAPELQAMRDADEEIGQKPRKLGVTWQNLTVKGIGSDAAFNENVVSQFYPFHQSAKDAPMKTIIDGSYGCVKPGEMLLVLGRPGSGCTTLLSVLANNRRGYEEVSGDVHYGNMSADEAKAYQGQIIMNTEDEIFFPSLTVEATVDFAARMKVPFHLPPGIKTREEYAQFYKDFLLRSVNISHTAHTKVGDAFIRGVSGGERKRVSIVECLTTRASVFCWDNSTRGLDASTALEWVRAIRAMTDILGLTTIVTLYQAGNGIYEHFDKVLVLDEGKQIFYGPQKDAVPFMEDLGFVRDSGSNRGDFLTGVTVPTERRVAEGYENTFPRDADGVRAAYDRSAIKARMVEECQAYPISTEAAENTAIFKEMVTREKQRYVPASSPVTANLAMQIQAAVTRQYQIMWGDKSTLFMKQGATLIQAFLGGSLFYNAPANNTGLFLKGGALFFSILYNSLLALGEVTDSFTGRPILAKHRSFALYDPAAFCIAQVVADLPILAFQVTQFGLVLYFLVGLKTTAGAFFTYLVTNYVTALSMTAFFRFVGAAFPTFDAATKVSGLSVVALFVYMGYMIIKPEMHPWLSWIFWINPMAYGFEALLGNEFHDQEIPCVGPYLIPNGPGYVGGNGGQACSGVGGAEPGATFVTGDAYLANMSFSHSHIWRNFGINCAWWVFYVGLTIFFTSRWKQVGEGNRTLLIPREQQHKSKHLLPSKDSEAPTEKTRGDNGAGASDGEVDTNLMRNKSIFTWKNLTYTVKTSDGDRVLLDNVQGYVKPGMLGALMGSSGAGKTTLLDVLAQRKTEGSIHGSVLVDGRPIPVSFQRSAGYVEQLDIHEPLATVREALEFSALLRQSRDIPTEEKLRYVDTIVDLLELNDLEHTLVGRPGNGLSIEQRKRLTIAVELVAKPSILIFLDEPTSGLDGQAAYNTVRFLRKLSAAGQAILVTIHQPSAQLFAQFDTLLLLTKGGKTVYFGDIGDNAATVKRYFGRYGAPCPPEANPAEHMIDVVSGEDGPYKDTDWNQVWLQSPEHDQLSKDLDQMIEVAASQPSSTNDDGNEFAVSMWTQVKLVTHRMNVSLFRNTEYVGNKFAMHISLALLNGFTFWQLGDSLTDLQQNLFTVFNFIFIAPGIIAQLQPLFIDRRDIYEAREKKSKMYHWAPFVTGLIVSEVPYLLICAVLYYVCWYFTAGLPTGAGHAGSVFFVVVMYEGLYTGIGQMIAAYTPNAVFASLVNPLVITTLVSFCGVMIPYSQIVEFWRYWMYYIDPFNYLMSSLLMFTTWDKPVHCKPHELAVFDPPSNTTCGDYLSDYQNGMGKTTNLLNPDAFADCQVCQYTSGADYLRTLNLKEEYYGWRNAGIVVVFVIGFYGLVYVMMKLRTKATKKAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELH6</accession>
    <name>S0ELH6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to YSP3-subtilisin-like protease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_10080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435316.1">
        <property type="nucleotide sequence ID" value="XM_023567946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELH6"/>
    <dbReference type="STRING" id="1279085.S0ELH6"/>
    <dbReference type="GeneID" id="35403547"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10080"/>
    <dbReference type="HOGENOM" id="CLU_511951_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496133" evidence="7">
        <location>
            <begin position="21"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="190"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT73238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="532" mass="59556" checksum="6DA4CE67A7720BE2" modified="2013-09-18" version="1">MMKEFLRYTLLGLLAQSSHGFLAPRSEQQAKYRIPSNKTSIIPHSYIVRLHDNHTIEDHYANIGVNISDVASEFNYLAPLDLYYFQLEAQNSTLIHELIRRDPGIKRVGHDYYGETEIDPIHHNPDGSDHGGSSSKQPVDTPAVSKRWDEMFFNAQWHLAMIGLWNKIRLKGDTVYPHADFRIPWLEDAGKGVNIYIFDSGIRLRLSAFGSQDGKMWNLNSLKEEDKAPYCDNETMRDTEGHGTKVAVVAAGYNNGMLSPAWRANLVSVKVKCKPNGGGRLSQILRAVSDVISEHKKYWGSPPDGWRGSVINVSMGFPKHATDPDFQYAWDAARAAGIPIAAAAGNTGENWLHAPARFKSTYSVGAIDARYQRWEQSHYHRKLNVFAPGVRVPTADHITGKPITGDGTSLASPLVAGVMAMMVGYEGAWNIPDGKNIYARLDANLVPLVTMDENMTKAGVEPNLINTGFFNPDREFDRHPYAGIPWTEPPEIGPGSFLDKRQGNPYDKQRGDYWNKNYYDGPQHTVEFGKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM56</accession>
    <name>S0EM56_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_11959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437957.1">
        <property type="nucleotide sequence ID" value="XM_023570916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM56"/>
    <dbReference type="STRING" id="1279085.S0EM56"/>
    <dbReference type="GeneID" id="35405419"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11959"/>
    <dbReference type="HOGENOM" id="CLU_007641_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="494"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT75911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1254" mass="142650" checksum="98476DC2BB904A24" modified="2013-09-18" version="1">MDPGIPDRPKKRDDFEVAIICALTLEADAVITLFDHHWEDDGFSYGKARGDPNAYSIGAIGQHNVVLAHLPGMGKVSAGNIAAFCRMSFPNIKLALLVGICGGAPTYNKGKSRIRLGDAIISTGIVQYDFGRRFPDQFEIKDSLNDIPGRPNLEIRSLLSKLMTTRESDRLQIESWKYLNKICQDAKRRATFPGRSKDLLFPVDYRHKHQDSLVCTICASCHQETDPVCDIALTSSCEQMGCDTSQYLQRDYREGDELHPLVHFGTFATGDTVMKSAKDRDHIAKQTQALGFEMESVGVWEVFPCVVIKSVCDYADSHKSKDWQSYAAACAASYTKGFIRYWDSTRHTESSSEPQQFRKRIIKSLSYVDMNERRNNIQSEAPSTFNWIFEGSVEYPGEQSPDWLSNQDYDTDRHSEPEWETETASNTEAEQEGSIEAHKDNGAGWETVSDENPREKDFPESDDDTEAEWGTESDERSETTDDCTRNHQRWRHWDSFVNWLKSDLPVYWITGKPGSGKSTLMKFLISDSRTPTALKEWKKNTIIIAHFFWEPGSTMQHSFKGLLCSLLCLILKNDKSISHSVLQRTIKDKDGKESPSDWDQRELRDLLLYYRNHSSQPICIFIDALDEISPEQDTLDALHMLRALISPTIKICVSSRPERLFRLHLQDEPSLEIHKLTGPDIEQYSKVSIRDSILLEPQGLKVSDLARRIGEMSQGVFLWAVLVTRSLIRGINNGDSKRDIYRRLNSTPQDLMDLYRDILMRSAADRDIYQQSASMIFNLVLILNKIPMPLFEATVATDGPLLDQLVVQGKGIHAQDLVTKGLRMVNTLEVGCAGLLEVRSSMNENSPTFRLKPLIAWLRTTITFIHRSAEEFLIDTEDGRKLWESCPCSQEELLIRRAKAKLAWYELYSSLVIVSEMKSCELPSVLETLTRWIREASLPRAVSTTILILAQKMYERGSLLTPETCRELLPLHSRRGQFLIYAVSFSHTTFVFNNLATFPTSERYETAYYIFYNACAELHSPDDDGNMMHEPGVVKFMIENGYSPNWPGSSETTTYKFGSPWLRYLLALHEKLTGRVKAILTSTQALAVLDTIRMFLKSGASVQSRFKIVFSWCRVPERRLPAHISLEALCIHPYKRFPCPDNSGFLILEINAKVLLESILVQVHGAIRPVSRLRLPEAASHTKALAFGNWNKKEYFIVDRNWVSELLVEGVKLWFRHATSKGDDTKLNNTVMKMCCCVTDKVSEASCRQGAWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMQ7</accession>
    <name>S0EMQ7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_11974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437968.1">
        <property type="nucleotide sequence ID" value="XM_023570933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMQ7"/>
    <dbReference type="GeneID" id="35405434"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11974"/>
    <dbReference type="HOGENOM" id="CLU_029871_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF16">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485470" evidence="8">
        <location>
            <begin position="18"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="435" mass="46882" checksum="36E35BAA7B40584C" modified="2013-09-18" version="1">MQWHYFLSLFLCVGVYGFPSYLEGPVGKVVSARLSGKVNDAVRSHDKRLSLGLASKPIKVTGEHEFIPPNFEKGDQRGPCPGLNALANHGYISRKGVTSLVEVAGAINQVYGMGVDLATILATMGTVFVGNPLSLNPGFSIGNTASGSQNILGNLFGLLGTPRGLNGSHNIIEGDSSNTRDDLYVTGDASTMDMKLFQSLYDMASEEGTYDFDAFAKRAKLRFHETVATNPNFYYGPFTGMIARNAGYFFACRLLSNHTVGSTEDIMDLGTLKSFFAVHEKDGKLVYKRGWERIPENWYRRSVDYGLISLNLDLLNLITKYPELGSIGGNMGEVNSYAGVDVSNITGGVLNLTKLLEGNNLLCFVFEIVKTVAPNSLSTLFSIIATPLELITDALGSALLNLACPAFKDLTVGGQSFEDGIKDKFPGASLGSSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMS5</accession>
    <name>S0EMS5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_11994</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437988.1">
        <property type="nucleotide sequence ID" value="XM_023570955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMS5"/>
    <dbReference type="STRING" id="1279085.S0EMS5"/>
    <dbReference type="GeneID" id="35405454"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11994"/>
    <dbReference type="HOGENOM" id="CLU_031922_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000012">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF69">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="397" mass="44076" checksum="5371799696C29683" modified="2013-09-18" version="1">MSAHASTRPNGTNGSTASVKGQLDASKLKFDLTTALKDVPKPGSAELWEQNVATDHMVTCRWTVQNGWEDPVIKAFGDLTISPLASCLHYATQCFEGMKVYRGYDNRVRLFRPDRNAKRLVMSAERVSLPGFDPEQLVELIKALVRVDAKRWLSEPGSFRYIRPALIGTGRQLGVQIPKEAILMVTLVCWPDFSTEVPPGVEPRSDLRLITSRNDTIRAWPGGFGYAKVGANYGPSFASHCEAQQAGYDQVLWLLGEEGQVTEAGASNFFAVVRDEKTSKPVLLTAPLTDRVILDGVTRRSVLDLVGSRLSEELEVREAKFSIKDIEKTWRNGLLQEAFVSGTAFFIKNVSTIRVGDFNIDLPQKQDDGSAFGPRIKNWLKDIMFGAEDHEWGVIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMT0</accession>
    <name>S0EMT0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_12098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438152.1">
        <property type="nucleotide sequence ID" value="XM_023571071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMT0"/>
    <dbReference type="GeneID" id="35405558"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12098"/>
    <dbReference type="HOGENOM" id="CLU_026304_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT76106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="475" mass="54465" checksum="EBEFB10F779836CC" modified="2013-09-18" version="1">MSVDDGRPRRVSSLVVPDAALAEELASLYFRYMHITFHNIFHRATFIAQVKDSSIPKILFFGVAGLSARYSTHPVFASITPWDRGRPYRDECKRLLDLEDTSLISIQACMLLAANASVEGDSRAESVYQAIASRMAMLLDLPNLPTESVLEQEINRRVWWSLITTETWSSATQSLPRYIKPRNTVPLPMDEGRFASLTYNMPEIQYDSSPGSSPICNFDPHSLVAQMIRLNLLLYDIIVFLNSRVVDTQDEHSVSESCDHQLRHSLDEWADNLPPRLRYSEENVIYWADEGFGAIFITLHINYNHAGQLLFYQNLQSAQEQDAGDESRQGFAQRCKQHATNLCDLIYEAKWRPDTVVLYPLAGHILCLASTVQIHTLLFGIDDDEIMAAKTRLETNFEMISSMNNYWPMNHMSISRLQHFHNACLRSKDDSFRLDAWMLQFLLGFTQDIKDRDAIWTYGHRALGEFDPLRDLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMT3</accession>
    <name>S0EMT3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_09454</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435806.1">
        <property type="nucleotide sequence ID" value="XM_023568643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMT3"/>
    <dbReference type="STRING" id="1279085.S0EMT3"/>
    <dbReference type="GeneID" id="35402922"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09454"/>
    <dbReference type="HOGENOM" id="CLU_030284_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496249" description="Proteophosphoglycan ppg4" evidence="12">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT73728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32082" checksum="510604C3A7B1A5A6" modified="2013-09-18" version="1">MYTSTLLLTLVASANAHIASWNKGMYCKGGNDSSVDNANTNLAVNPLYDLPKSKWWMQADRGCDAVPPPKGEFLELPAGKSFMTELANNRAFTTLSYKGELTTEWQDGKNRSMPWRGPEGGCLMDGGDGSGGELHTKNIESTGGTAWAISYESDISKVTMDNLVVFSVRYYSPFFRETWYDVPADMPACPEEGCYCAWLWIPDGCGQPNMYMQNHRCKVTGSTSTKKLGKPKPPVYCRDNPTKCVPGPKQMMAWNQAEGNNVNPPNGKTPTYNQRMGFMDGAQDDIFVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMV5</accession>
    <name>S0EMV5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_14223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438192.1">
        <property type="nucleotide sequence ID" value="XM_023571131.1"/>
    </dbReference>
    <dbReference type="GeneID" id="35407675"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14223"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="1182"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="842"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="851"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="885"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1041"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1105"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1116"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT76146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1317" mass="148263" checksum="2E5EED9ACC2042B4" modified="2013-09-18" version="1">MESSIRDTGISIAYEPEKSAPVVDILFVHGLGGHPRKTWTCSKGPPAIHESLSASEPSRKNSRRSVLGRTLGRLHRTSRTTVVEPRRDALRDDANPAVVFWPVDLLSKDFPDSRILVFGYDSKITKYSAGAVSENSVFSHAKDLLFALALERPLHRPLICVAHSLGGIIFKETLSRSSSSTRREHQNILESVEAVIFLGTPHRGSVDIAAKGEVARSLLSALGVATTPVILDSLGLKNTDLERAQEEFSRLWHTSNFRVKTFQEGLILPKLGKKVVPEYSSLLGNHREHAETLQADHLEMCRYSGKDDPNYRKVAGEIRSTYLLVTATNKLESLGRWEEKSQSPVPSVGASQYSRNDFQDQAGRAWLQSLWFSAINRRYESLGSPAEHTCHWLFDDENFHNWLHGRNQERYQGLIWIKGKPGSGKSMLMGEAFRRANRRQAEASTPSQTAAFFFSGKGDEPEHSVVGLFRSLIYQLCSKNALFMQSFQEICDAKTKTGCFMASEAIAWQEAELKAALENMILQKTSSKLLIFVDALDECDSGSVRDLAYFWRKITKSAFASGIDLKVCLSSRHSPSVTVSDCPEIIMEQHNGHDISTYLKQRIEIGIGIHNAQWQILEEKIRERSDGMFLWVVLVVDELLRSWDEGRSLEYLTKRVENTPQALETLFSEMLSHFAPERKNVAVKLFQWATLSMKPLRLHEWHHIMGFIRHPTPTSLAEWRASDYFTETDEQLVKQINSLSLGLVEVTGAIEVPPHGSGSDVSSVGVDAGSLTPEHGGTRIVQVIHESVRDFFLRGNGFSALDTSFSTHPIGRGHLSIMATCLDYVNIGELDALVGARQRITHQGKDKNEEQSPTSLTESSSDCSLGHEEHPLQGTITLPLRHKTIPGDDSRPEKAVTDSPESDPFVAVHRWLKESTDSTAESDLLIDIPRAPFSDVSDTPRSQILEDHPALLSYATFALFEHARLAYIDRADVTPILDRLNDETTWARWKSLREDVPQAVKLLDFLEDVGLVSWISAFHDRFSPGQKRQGSPLMKDLPTSPIDTQRSTLYPSHQLSGGETRRSSLPVPLSIPQVDPQEHPPPMSRPRWRGESPQSLNRVPRRQVSVASFGSASSHDGYDRFSPRLESPRPVNSKDFRGTPVNSQDLGRTKVIGFFVCECCPKKPKRFDTQEELAAHESEKQFECSYCGNRFKSQAEAERHQNSLHIRKQSWSCSNLLGYDSAFQESSQRPEKCDTCGYCGDDFPRSGTAGNETYATEQDWDERIRHLQEVHKFRECNSTKKFYRADHFRQHLKHSHMATRGKWTDKLGELCCKKEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN12</accession>
    <name>S0EN12_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_09338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435916.1">
        <property type="nucleotide sequence ID" value="XM_023568771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN12"/>
    <dbReference type="STRING" id="1279085.S0EN12"/>
    <dbReference type="GeneID" id="35402807"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09338"/>
    <dbReference type="HOGENOM" id="CLU_065993_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005071">
        <property type="entry name" value="PRK06489.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485802" description="AB hydrolase-1 domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT73838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="361" mass="40084" checksum="87B99D24D1EFA449" modified="2013-09-18" version="1">MKTWNKAILTMGFFSPLMYAKASWPMPNRGSFNIEDFKFDSGEIIDSLNISYQTIGELKVNPDGSNNAVVLLHGTTGSSAQFLVEEFAGALFNPGQPLDADEYFIVMRDAIGHGNSSKPSNTDLRASFPKYQYPDMIRADHLLMTEHFKLNRTRLTLGVSMGGMHTWMMGEEYPGFSDALMPISSSPVEIAGHNRLFRKFITELITIDPAWKGGDYEKQPAAGLGGALMIQLVLLSSPSYWQRAFPTREAVDKYVDEHIIPRLEDFDANDQLYAWNASQTYNPKASLKNIKVPLTAVNTADDLLNPIELGLLEDGVANDMTPGYGRAVTIPASNETTGHDSYIMADIWKDELEKLLARSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENA5</accession>
    <name>S0ENA5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to channel proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437495.1">
        <property type="nucleotide sequence ID" value="XM_023570372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENA5"/>
    <dbReference type="STRING" id="1279085.S0ENA5"/>
    <dbReference type="GeneID" id="35404932"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11470"/>
    <dbReference type="HOGENOM" id="CLU_020019_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF24">
        <property type="entry name" value="MIP AQUAPORIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="551" mass="60715" checksum="955F09C7169DF6F4" modified="2013-09-18" version="1">MTGHQDQNHDYFSKPATPSTPGQVHLGNVASRIPSTISDRETGQPDHAKSTHSRRRGLHGLPSSFMSRMSKRPMSSRRFTRMSSGHSTARPTVQQHASQYHTYAPAEEGYYEENPWFGEAGKKPIFSLGKPLPHRVRRKVVKPIRPDGKVDEEMAIVKEDSEDTPAGYASRTTSGQPYRMHTQTSIGSRDMQNQQSRTTAAGVAHNEKRNDAGQPVFDYVPGEATPAATPVHRDPASRVASHQQSNNQPDYKIDSEPLGQQEKPEVEAGETDPNEMRNWWARIRAKHPEPLAEFLATSVAIFLGLTGTLSVNLSAKQSQTYGTYETSCWAWGFAWMFGIYLGGGVSGAHMNPAISISLSLFRGFPWRQCFIYILAQFIASIVAGALAYGIYADSIHYVDPEMDGMSKTFFSTPREWVSLQSAFFNQVVGSAIMMIAVFALGDDQNNPPGAGMHALVLGFLVTTLKFTLGYNIGSALNPASDFGPRVVAYAVGYRGSNVFHSGWWFYGPWAATLIGSVVGCALYDGFVFVGSESPINFRFSKEIKHRANKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENV4</accession>
    <name>S0ENV4_GIBF5</name>
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        <submittedName>
            <fullName evidence="6">Related to phospholipid-translocating ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_11968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
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        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT75919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="313" mass="34732" checksum="9FD375FA9AC4930A" modified="2013-09-18" version="1">MSDPLICTHVSKECPIELTTYGYRPNLGGNIFLAVIFGIAFVANIVLGIRFRIRAYAIVLSLGCLAQVLGYVGRVGMYFNPFDAIPFQAQICCLIIGPAFNSAAVYLMLKHIVALFGAKWSVLEPKWYTIIFITADVVSLVLQAVGGGITATSDFRTDHDRIEMGNNIMMAGIAFQVVTLSIFAILATLFCVRRIRALTTNPLEGNSLQAWRTRRFRLFLGGLATAFMAIYIRCVYRIAEMRGGWGNKLMREQIPFIIFESVMILTATLAQTILHPGYFFPWFADQTPKLDAESSYTELSIVSGSRTGFEGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENV5</accession>
    <name>S0ENV5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436476.1">
        <property type="nucleotide sequence ID" value="XM_023569232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENV5"/>
    <dbReference type="GeneID" id="35403911"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10446"/>
    <dbReference type="HOGENOM" id="CLU_2049877_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="120" mass="14599" checksum="52B422C10A96BDC8" modified="2013-09-18" version="1">MPSRRHRKESNDPQPSGPRSNTEGPNQQEIKNLSERLAAIRLEIEQTFLLKEERVKRAKSQWQRIERMERERRPKEEIEKEKKELKYRVADMEGIIKVLEQTRVGEEEIFLKRWHLQHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPH0</accession>
    <name>S0EPH0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3500 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437181.1">
        <property type="nucleotide sequence ID" value="XM_023570057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPH0"/>
    <dbReference type="STRING" id="1279085.S0EPH0"/>
    <dbReference type="GeneID" id="35404651"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11187"/>
    <dbReference type="HOGENOM" id="CLU_033093_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489:SF1">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47882" checksum="5AAA0FC20F62378C" modified="2013-09-18" version="1">MTQIRSPAGFRNYIPPADIPRSIQLAESDTYQWANHRCSEPFMIGWMKAWKERYGQPYKGIITDGKVIPKLFRLANKIENFGAPKNAVKAAQNAINVASEEERQKLPRPVGAPEWRFWMNPEIYVFKHGVRLEEASKDLIAALHGLMQSSLSAKGYEKAHGCMKVNQFLGEVVNGTKVLNENSYNFVIFGTPSPEEPWGWQIFGHHLCMNFFMVGTQMVVSPVFMGAEPNIIDAGPHEGLDLFVDQEQTALGLMQLLDPEVQKDVQIYKKLSGDEYPPGRWHRADQRHLGGAFQDNRIVPYEGVRVTTFSEPQQDAVRKLVELSLNYLPENALASHLEQIASHWDDTWFCWIGGFGDRDAFYYKVHSPVIMVEFDHHSGVFLNNKEPLPFHIHTLVRTPNGNDYGKQLLRQYQGRKDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI16</accession>
    <name>S0DI16_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to steroid 5 alpha-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_01841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423762.1">
        <property type="nucleotide sequence ID" value="XM_023574240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI16"/>
    <dbReference type="STRING" id="1279085.S0DI16"/>
    <dbReference type="GeneID" id="35395324"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01841"/>
    <dbReference type="HOGENOM" id="CLU_065395_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016636">
        <property type="entry name" value="3-oxo-5-alpha-steroid_4-DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015596">
        <property type="entry name" value="5_alpha-SR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="117"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT61681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="290" mass="33459" checksum="958C9E3CA1BFB798" modified="2013-09-18" version="1">MAIIEGWLPPTRENYDLMLKVWQISYPIIGSMQWLTSWYGMGKTSVTSRLNLPGRIGWLTMEAPGFLTLLYLMKVLPEQYGIDDLPWQNKVLAGLFVIHYSYRAVMFPYLQPSMSPVHIAVWLLAFSFQICNATCIGSWLAAYGPTTEAAWSSQSSILQFSSGILIFYLGLSGNFFHDEELRDIRRREAQRQERAKLDGHAGNKGGVEKHYQIPQAGLFRYMLYPHYLCEWVEWAGFWMAAGWGCAPARAFVVNEMFAMFPRAVRGRRWYLERFGEDKVGRRWAVIPGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIF6</accession>
    <name>S0DIF6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_01282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424270.1">
        <property type="nucleotide sequence ID" value="XM_023580462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIF6"/>
    <dbReference type="STRING" id="1279085.S0DIF6"/>
    <dbReference type="GeneID" id="35394767"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01282"/>
    <dbReference type="HOGENOM" id="CLU_041217_13_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT62189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="216" mass="24482" checksum="CB531D05EE2C2C8C" modified="2013-09-18" version="1">MAEQQTPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYMATLGVEVHPLGFTTNFGQIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPQLEFVAAPALAPPTAQVDEKLLEEYRKEMDEAAAMPLPGELSDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIS7</accession>
    <name>S0DIS7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoserine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424251.1">
        <property type="nucleotide sequence ID" value="XM_023580216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIS7"/>
    <dbReference type="STRING" id="1279085.S0DIS7"/>
    <dbReference type="GeneID" id="35394789"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01304"/>
    <dbReference type="HOGENOM" id="CLU_056574_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd01427">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF1">
        <property type="entry name" value="COLD TOLERANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT62170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30033" checksum="D2BC5EBE4EB36BFA" modified="2013-09-18" version="1">MHLVFDFDGTITQEDSIGELARSALEIQRNKYGHDLQTSWDQVVQSYVADYRHYKDNHPSPEVTRTSVDHEIEFLSGMKDVEETSLRRIADSRIFAGLDAETLSQAGADAVKAGRIKIRDGFTDLITLARQRGWDVSVISVNWSRAFLRGALLPHKIEVIANEPASDGTIKGPEFFEGRMTNVCEKKKALKHIINEKDGEVIYFGDSTTDMQCLLTGGVVISDNEESSLLKTLRRVGIEVPHIGEKRNGKISWARNFREVLDSGLLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIU4</accession>
    <name>S0DIU4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424177.1">
        <property type="nucleotide sequence ID" value="XM_023579328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIU4"/>
    <dbReference type="GeneID" id="35394869"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01384"/>
    <dbReference type="HOGENOM" id="CLU_1835323_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="140" mass="15196" checksum="CE8CCE0F2E910A36" modified="2013-09-18" version="1">MGKWEDGDGWALTPCFLVPAPPSKPKPASPRQCTSRPAHGAQVTAEGVEQQSKQRVALSLTSEHLSRRIESWWKTANPSKGGVQFKVDRAFDLYVPAEVVTTTITVVVGQTALPGILGVSPWCVLCILRLMPRSIFPGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJA6</accession>
    <name>S0DJA6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable RAS GTPase-activating protein sar1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424655.1">
        <property type="nucleotide sequence ID" value="XM_023570330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJA6"/>
    <dbReference type="STRING" id="1279085.S0DJA6"/>
    <dbReference type="GeneID" id="35394348"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00863"/>
    <dbReference type="HOGENOM" id="CLU_009455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="143"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="737" mass="84750" checksum="89450796D3FFBE6C" modified="2013-09-18" version="1">MSSYDGSRSARQSKRYSMSALYMSISANEGDLQIEDELAKAQKALRDLKSKISSQSKKNFVLEKDVRYLDSRIALLIQNRMALEEQNEVASHLEDALEMQQGVFPNDDKTQKYGNLLLVSMSEIDSLLQTVMFTIYGNQYESREEHLLLTMFQSVLTYQFDNTPDYSSLLRANTPVSRMMTTYTRRGPGQSFLKSVLADRINGLIELKDLDLEINPLKVYERMIEQIEEDTGQLPPHLPKGITGEQAAENPQVQAIIEPRLTMLTEIANGFLTTIIEGLEEAPYGIRWICKQIRSLTKRKYPDANDQVICTLIGGFFFLRFINPAIVTPKSYMLIDGTPAERPRRTLTYIAKMLQNLANKPSYAKEPYMAKLQPFIHQNKDRINKFMLDLCEVQDFYESLEMDNYVALSKKDLELEITLNEVYAMHSLLDKHHDELCKDDNSHLAIIMSELGSSPPQLPRKENRVINLPLFSRWESAIGDLTAALDITQEEVYFMEAKSIFVQVMRSIPATSGVARRPLRLERIADAAATNRSDAVMVRKGIRAMELLSQLQELRVIDKADQFSLLRDEVEQELQHLGSLKEGVITETQKLQEVYKTIRDHNVYLNGQLETYKSYLHNVRSQSEGTKRKQQKQQVLGPYKFTHQQLEKEGVIQKSNVPDNRRANIYFNFTSPLPGTFVISLHYKGRNRGLLELDLKLDDLLEMQKDNQDDLDLEYVQFNVPKVLALLNKRFARKKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKH4</accession>
    <name>S0DKH4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423948.1">
        <property type="nucleotide sequence ID" value="XM_023576484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKH4"/>
    <dbReference type="STRING" id="1279085.S0DKH4"/>
    <dbReference type="GeneID" id="35395123"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01638"/>
    <dbReference type="HOGENOM" id="CLU_015126_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF1">
        <property type="entry name" value="VTC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="818" mass="92308" checksum="C690147881D89537" modified="2013-09-18" version="1">MTDQGEKKGLWSMLRRASSRRHSTKPPPKDLEPREYHRPRRASNGDVGHAPFRQSIGSAPDLTYDSQRPPTAEDESNMRRRPKRGQPEPEPEPRSSPIRSKSSGFLNKSRASNGSRPSNGRPVRARDPQSAWPPYGISMNDELPHQHALELVARGAPSHKGHKRPIPHQPEEFYALYTTSSGNRGDGKSSDTTDVSNLHDSMTQLMTLRMIGHGYADRPWETLEQPSFAFFFGHLPGTITLNEWASMSSVLPPTIALRDAGVMPRTMSLESIFDRLQELRHGIEDDDESLLYRVLYKRILRDPEKFLNPHKTLDKQITDLIMVLSRPDWIDFSNPRNQVATRFIFDRSPGNEEQFHKFFHQLLLSLELELRIQSDQHSDWAKEKLTSQIPPSIQWNLALARRWQDFVRVDDVGKTPEEILLRYKLKKRQIRMLRRFAQMMRWPNLADTLDNMKQKDSELALDEVSSDAFAFFSGLVLPGQTFPFLIMNTLLDLDPDSATDNLALLSHMHPHCGFQYKNSYTYWSATSIVGKVLAPTCHAVAGWIGPARPTKDLDTTQIARIRSRKPIQRMSPQDVESMAERSDPLGPAADAYPVEDYQPVRPKGGPEDAIDTVRIELLSLKPADGPGDAPTAAGLSRLFDATVQFAIDGVSWPLKLMYDVSFVAAWPCSDGPHPLFFDYIYTSIRVDAIVGVRDWGGLYGGPQLHSVRSSPGPGMMRGPYRDMFSQSFNHNHAPLNGFMQTGALEEEDENDDEKVLVVEAFGVRDNEVLARAWCSHWGLSAVVADIRRTCVACAIREAYAATLTVVILVEGQEYPNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLE8</accession>
    <name>S0DLE8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to putative venom metalloproteinase jararhagin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_00834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425520.1">
        <property type="nucleotide sequence ID" value="XM_023570652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLE8"/>
    <dbReference type="STRING" id="1279085.S0DLE8"/>
    <dbReference type="GeneID" id="35394319"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00834"/>
    <dbReference type="HOGENOM" id="CLU_012383_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485047" evidence="3">
        <location>
            <begin position="24"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="677"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="5">
        <location>
            <begin position="268"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="4">
        <location>
            <begin position="508"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT63439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="756" mass="81700" checksum="586C26B7BB163077" modified="2013-09-18" version="1">MVSLRSIATAIAGVALFFETSLASSVKRNAVNYISFINEPVINTPSHRIRADSHFDLLFSLHNGQQKIRLKLEPNHDILHENFAITHIGADGAVRSVETVNREDEKVFKGHVFIQRVGREGWTNAGWARITMHRDGKEPVFEGTLRIDGNHHHIHTGTNYQQVRHEDDPILSTADARDDVMVVWRDSDIMSFNPTELKRRGASAALCDSDTLGFNSKFHELQDFDTFGAANTKSLFGRQSIDTGTGNDGSSVDLESTIGSVNGCPTSRRVALLGIATDCGYTSTFNSTEALRKNVIRMVNDASEVYEKSFNITLGIQNLTISDGSCPGSPSDTAPWNQKCSNSVDLSDRLNLFSAWRGQNEDSNAYWTLLSTCNTDSAVGLAWLGQLCRPGASANSNTGGRNETVAGANVVVKTSAEWQVFAHETGHTFGAVHDCTSQTCPVSSDAQSCCPLSKSSCDAQGDYIMNPSSREGINEFSPCTIGNICSGFRRNVNTECLTDNRNVKTISGQQCGNGIVEEGEDCDCGGEASCGDNPCCDAKNLQIQGFASSGTVCRSSTGPCDPEEKCTGSSATCPKDKHSDDGTDCGDSLQCASGQCTSRDEQCRANYQNTTSSSVKACTNSCLLSCQASGDGFCTQRNQNFLDGTPCGGGGRCQNGSCEGASTWKEIENWFKNNKNIAIPVGCVLAALLLLSISCCCFSCIKRRIARRRAAKQPAMGAWPGYPRGPAPNQQGPYMYAPIDNNSGWQQQRTRSMRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLF4</accession>
    <name>S0DLF4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425336.1">
        <property type="nucleotide sequence ID" value="XM_023573648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLF4"/>
    <dbReference type="STRING" id="1279085.S0DLF4"/>
    <dbReference type="GeneID" id="35393604"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00119"/>
    <dbReference type="HOGENOM" id="CLU_083352_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="230" mass="24430" checksum="FC98CE6D0AB2097B" modified="2013-09-18" version="1">MVNKFTIVINNRSGSSQNYTLFTEKPEVTGISKSSIWTNAYQTADGTPDGATAEFELWKNYYAIVGKWKGGAKDGAKAFVSQAQPVTLGSTAGDGSLVSGTTLSISVANGNASIDRAANNDTARSGAFEVDTKNDFTLEIATENNIFVGVASSPDGNDRVATATFRPEPGNQYQIQPSNVFYVATGPSFQTGQLLDPAKLGRQPIKIDFNVRSPVVTINHTPDGQLVVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN92</accession>
    <name>S0DN92_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_04922</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425987.1">
        <property type="nucleotide sequence ID" value="XM_023571734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN92"/>
    <dbReference type="STRING" id="1279085.S0DN92"/>
    <dbReference type="GeneID" id="35398403"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04922"/>
    <dbReference type="HOGENOM" id="CLU_015166_10_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="59"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="158"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="305"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT63906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="396" mass="43023" checksum="B71A5C86B841B460" modified="2013-09-18" version="1">MSSADAAQMEHTSMADVARNRNIQSHVSSHTLSKSPKEPPVCPTDQEAVAPKAQMNSFEYVWKSGVAGGLAGCAGKTVVAPLDRVKILFQASNPRFAKYTGSWVGVASAMKDIHRYEGITGLYRGHSATLLRIFPYAGIKFLAYEQIRAIIIPDKHHETPMRRLLSGSLAGVTSVFFTYPLEVMRVRLAFETKRDGHSSLSSICRQIYNEQPVQKTTATRLPNAPATVTAAAEATAATVGAIAPQTGLINFYRGFAPTVMGMLPYAGMSFLTHDTVGDILRSPRFAKHTTLPKKANHPEGKPAPLRSWAELTAGGIAGLISQTASYPLEVIRRRMQVGGAVGDGRRLRIGETAGMIFRERGVPGFFVGLTIGYVKVFPMAAVAFYTYERMKLVFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNX9</accession>
    <name>S0DNX9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04504</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426370.1">
        <property type="nucleotide sequence ID" value="XM_023572203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNX9"/>
    <dbReference type="STRING" id="1279085.S0DNX9"/>
    <dbReference type="GeneID" id="35397985"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04504"/>
    <dbReference type="HOGENOM" id="CLU_012079_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000162">
        <property type="entry name" value="Beta-1,4-mannosyltransferase (Alg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT64289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="481" mass="53033" checksum="03634E6A6FD37C9A" modified="2013-09-18" version="1">MSAAFIVSVFAGALSCVFLVWLIRGLAILIPTCYQPSQKPEDDHIQILVVGDVGRSPRMQYHALSVAKHGRNVDIVGYKGMVPSPAYRDLCAHPNNGAETSRHPDLIGNPRVTMYALPPQPEVLQWGTLPFFLSIPLKVLWQFWGLFSTLMYDAPAAKWIIIQNPPSIPTFHVALLVSFLRGSKLVVDWHNYGYTILAQGKWYVKPLVPVYRWYETGFGRYLGDINLSVTDAMARQLKERPFNLKRSVLTLHDRPAQVFQPILSTTKRLAFLSRLAETKDIAKDIVDGAVRLIVSSTSWTPDEDFGLLLDALVSYASSAEASPILAIITGKGPQKELYLEKIKTLQEGGKLPGVRIITAWLSTRDYASLLASADLGISLHKSSSGVDLPMKVVDMFGAGLPVAAYSAFESFSELVKEGQNGCGFETSSELAEILARLLSFSGQEELARLKKGAVSEGSLRWDQEWDRVVGKVIGLVGEESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPP9</accession>
    <name>S0DPP9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_04358</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426502.1">
        <property type="nucleotide sequence ID" value="XM_023572366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPP9"/>
    <dbReference type="STRING" id="1279085.S0DPP9"/>
    <dbReference type="GeneID" id="35397839"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04358"/>
    <dbReference type="HOGENOM" id="CLU_000288_26_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000007">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="582"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="371"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="491"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT64421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="862" mass="94044" checksum="5439346D1FB3EECC" modified="2013-09-18" version="1">MDGPGYTSASSASAHTATSHRRKLIKKPPTYAYARSSSGFDGGAFDAQSLESKRSSQSLRRAPSAPPTRSNPATVSDWQDSDRSHPQLSANSNTLRPIPSPISPQGDFTPANHWAPVPRHPDRLSDSHLRPLSKTAVPDDLIGAPFDGAAILNRIESIKIPSPKAAAPRQFPPQIVKVPTDSRLASPALRTSTSFSAMDSSLNEKSLGPRAPTDGPSINPKRYSDDGKDLKPAVLRKKSGFSGFMNSLVGSPKKPVISAPENPVHVTHVGYDSSTGQFTGLPKEWQRLINESGIPEKERRENPQTMVDILQFYKETTERPPEDQVLEKFHHAGQYATSPATAASPGMYPSNYMGMSPNNISPTNPRFPTVNHEGSFENPRAPPPVPRGQVGKDLMPSRPAPKPPVSMSNRHMPQGAYSTKDSGIGMSQSGDESYGMSKDAGPMLPEEHRSRSNSRVAGPTYAPTAPQPNPQLAQAQAAAYQQQLMQQQQEQAMAQAQAAMSGSIGRAPSKRTPHPQNPNMQAAPGYGRAPESNGVHNAPRQQAPGAAVPGARPRHRARQSAGLDIVAALKRICSEGDPRDIYRGFNKIGQGASGGVFTGHERGTNRLVAIKQMNLEQQPKKDLIINEILVMKDSSHPNIVNFIDSYLCGGELWVVMEFMEGGSLTDVVTFNIMSEGQIASVCRETLLGLQHLHSKGVIHRDIKSDNILLSLEGKIKLTDFGFCATINEAQNKRTTMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALWLIATNGTPHIKNEQDLSPVFKDFLYFALKVDPEKRASAHDLLRHEFMKQCVDLGQLSPLVRAAREQRAQEKARKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ67</accession>
    <name>S0DQ67_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable Identified by gene-trapping, microarray-based expression analysis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425613.1">
        <property type="nucleotide sequence ID" value="XM_023571279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ67"/>
    <dbReference type="STRING" id="1279085.S0DQ67"/>
    <dbReference type="GeneID" id="35407850"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14399"/>
    <dbReference type="HOGENOM" id="CLU_112614_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="89" mass="9955" checksum="A5C1F86679EDC1D3" modified="2013-09-18" version="1">MVCIHTENQNQGDFYPFVLLEISVLHEPPLGHLRYGLTDVPPQPNSPPDNVFNPARPAKDLKTRSWTGISPAPKLPPILHLLCLFTMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQI3</accession>
    <name>S0DQI3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to light induced alcohol dehydrogenase Bli-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426920.1">
        <property type="nucleotide sequence ID" value="XM_023572875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQI3"/>
    <dbReference type="STRING" id="1279085.S0DQI3"/>
    <dbReference type="GeneID" id="35397383"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03902"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT64839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="344" mass="37209" checksum="F410DCE26ECE1CE3" modified="2013-09-18" version="1">MVDHKEILRPKYSFDDNPSLAGKVALVTGANTPDGVGYHIAHQLALKGAKVYIGARNLQKATKAIRTMVAESPQLKPESLVPFAVDMGNFKQVQYAARKVVAEEPRLDILVNNAAVLARPLDKDGNGISVSFGINHLGPFLLTRELLPLLNKTQAEHPGVRIVNVASTAHYDVPAGAKFGSLEDFNATYGSEDEPSANYLRYGYSKLASILHTKELQRRFDQEGVDILALSVHPGGVATNGAAGYLGGRDNDIFRSNLSPFEGAITPLFAAAHPEPAQHRDKYAGSFIMPFGGLKEPTEDANNAELAKQLWTTSEKVVSSVLDCFIWDSILMPMGGIFNIGQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQR8</accession>
    <name>S0DQR8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425838.1">
        <property type="nucleotide sequence ID" value="XM_023571551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQR8"/>
    <dbReference type="STRING" id="1279085.S0DQR8"/>
    <dbReference type="GeneID" id="35398566"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05085"/>
    <dbReference type="HOGENOM" id="CLU_062856_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="297" mass="32307" checksum="9E995B5525897175" modified="2013-09-18" version="1">MAAKSTVKVPHLGGIDAGYRVSGSGIDSSKPTLVLVNSMCTTSSLFEAQFSAPELTDKINLLAIEPLGHGATSSKSEHFTYWDSAIMNLQVMEALGVDKAFALGTSAGGWIVVRMALLAPEKILGVLPLGTSMDYESAESREKGCWDPKTQLGPFYENWHSTTPTPDFVVDDVWRGLVSSVGFGSNPSPETLAFWDETLKQVYRGDEGRKKLRIAVVNLFERDGLLLRLRDVKCPVYWLQGTADPVFGTTVPTEHIKLFTSSPEATLGFVEGGGHYLSATNPKEINEAILKMVTKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRV5</accession>
    <name>S0DRV5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427257.1">
        <property type="nucleotide sequence ID" value="XM_023573789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRV5"/>
    <dbReference type="STRING" id="1279085.S0DRV5"/>
    <dbReference type="GeneID" id="35395579"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02096"/>
    <dbReference type="HOGENOM" id="CLU_1454496_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT65176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="190" mass="21539" checksum="853F44600E680A85" modified="2013-09-18" version="1">MREGAGTDALSKLAFHAERIVLLDIVSPRSQVSDQSREAIKGLQYVIEPVQDAEEIALKAEIPPLLPPSALSACQLHDKEIRSREAGRIHARNSFPTTVPWLRRLGSDLHLKDIGRKKDFLRNLIGLEYEVDPNNPDESDDSQLGFIHITFDWMINYAKAVITLDIISWNALFEVNRKELDKDRGMLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSE7</accession>
    <name>S0DSE7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427565.1">
        <property type="nucleotide sequence ID" value="XM_023574156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSE7"/>
    <dbReference type="GeneID" id="35395909"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02427"/>
    <dbReference type="HOGENOM" id="CLU_045148_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="314" mass="35462" checksum="E25E149A8132999C" modified="2013-09-18" version="1">MHLSVIYRREDGLVYSPKAVLVIATSTLALYNACELLALIFTTFKQHHGLYFWSLLLTTLGVFPYALGWLFGYLDILGTDASKAIASLGWIVLVSGQSVVLYSRLHLVLNNMRIQRAVLWMIVVNGTIWHTTQTALLFTIGPSVDGNNPTRIFVAIEKIQMTIFCAQEFVISGLYLWGTIDILQTSLGNKQKTMWYLLIINLLIVAMDIALLIIMYKDHYTIEQGVKLVIYSTKLKLEFAVLGKLVDVAQSRGGSSVSETHPSRFIEMHARGHGRSDNFPEIVHFENTAARRMADDEESMRHLYDDAIKQIYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSQ0</accession>
    <name>S0DSQ0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426513.1">
        <property type="nucleotide sequence ID" value="XM_023572380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSQ0"/>
    <dbReference type="STRING" id="1279085.S0DSQ0"/>
    <dbReference type="GeneID" id="35397826"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04345"/>
    <dbReference type="HOGENOM" id="CLU_074183_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="237" mass="24497" checksum="1FDFA04976E30B62" modified="2013-09-18" version="1">MSISHPTPPLLLTKRLTAFLNANRTPQLPTLLLTSPHGKLLAHASPHPVAALRTHATVAASLLAIHSTSAPALAASLPGSRTPDPIGSSPPEEDDLEDETDRLSQSQQLDSHKSGKGRGIKPATVTVQLTSGTVVIRRLKCGLLFVCVGPANPDVTEHGVPNVHDLHVPAGESSHVGSPDGADSILSTGGQTTASLESNAGSAAAVTALRRHATELARWLDDKLGTLTVPEEGVGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSQ3</accession>
    <name>S0DSQ3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_02408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427546.1">
        <property type="nucleotide sequence ID" value="XM_023574134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSQ3"/>
    <dbReference type="STRING" id="1279085.S0DSQ3"/>
    <dbReference type="GeneID" id="35395890"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02408"/>
    <dbReference type="HOGENOM" id="CLU_103791_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990593">
        <property type="term" value="F:nascent polypeptide-associated complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061770">
        <property type="term" value="F:translation elongation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="163" mass="19182" checksum="C683302B87E50F89" modified="2013-09-18" version="1">MDPLDNMAGAPVPKNFDAENAQNNEDIEKQFAVKVVQHMQTYWSILERVKGSSLRLTKIDDEIMEHLKTDFPEFDPAAKVDEDEMKSKAGKERWRKFMMAYEKKVDDYNFGTMVRDRPDVEYEEDTTIFVPRMQFYALEIARNRAGLNDWIYEQAQAQKNKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSU0</accession>
    <name>S0DSU0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427576.1">
        <property type="nucleotide sequence ID" value="XM_023574169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSU0"/>
    <dbReference type="STRING" id="1279085.S0DSU0"/>
    <dbReference type="GeneID" id="35395921"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02439"/>
    <dbReference type="HOGENOM" id="CLU_1415279_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF166">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G01210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT65495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20077" checksum="7AC5B79066892946" modified="2013-09-18" version="1">MSDASLIIVDSPAHAPGVSVITLNRPEKRNAVSKAMIIEFLGALSRASADSNTKVIVITGYGSCFSGELSSKPRFLGSLLTCSTAGADIKEISTMDAEAARSCRYLEDLCHGMAAAMKAILLGTPISSEEALSCGLVCDMFKDGQVLDKTIEAAAQLAARGGVAVQLAKKAICRGLLTYFVSYCGLELMVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTC8</accession>
    <name>S0DTC8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to intermediate filament protein MDM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426713.1">
        <property type="nucleotide sequence ID" value="XM_023572624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTC8"/>
    <dbReference type="STRING" id="1279085.S0DTC8"/>
    <dbReference type="GeneID" id="35397608"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04127"/>
    <dbReference type="HOGENOM" id="CLU_002131_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="414"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="880"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="773"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1231" mass="137801" checksum="41F9736D5941B6E7" modified="2013-09-18" version="1">MALKRRDVIVAGLAAFIAWGFAASWSPVLRWAGHAFVAGSLVTLVALLAGLFLVSRRPSDRKLQPHGVTFLDRKSWRLEVQALRQRQSYTPTPINPESPRVSEAIDNLLGLITRDFVNSWYSNISRNPSFSNQVDQAVRQALLSLTDSLRHKDLAELVTSRLVPLLTAHFRDFYEAEKSVRGKKLNRSVTESEELDLAIASKFRDGRLHPAASLSFPDTKMVQQDYLRSLVAKIVPKVLPENMLSSRAVSIIIREIVACAVLFPVIQLLSEPDTWNQLMENLGRSMLQDRSTVRKLRAALDQHAPSTPKASKLASMPRVAPGDSERKFEKFIRAIRKVNNLSDARRFRSEVASQLKRDSLEDNQDQVYLRRLEMGKRLLDQRVNHLAAGGERRPPGPLPLPSTSSSQSKLESAPLVDILRDSSALSYFMEYMDRQNLMPLVQFWLVVDGFRNPLEDDGPDDELPSTLPMWTDADRQDLQQINQAYLSRPELKVPEHSRNEVKDFIKAGKSATPLQYYRARRAILKAQSAVLEEMRSRFFQSFKKSDLFYKCLAAEEASNIQTLRSTPQPEVQAQAQAQASATNRASKTLPAKPRPVSRLTPQLSNAGKRTGSASDLKSLTSNGNGHGHRARRSLDEGSVNPLFDDDDVDTDGLGDSVQSLDPETNSQQLPDTQVVKAVEQAFTDIMEDDRPQTAEALRASLFGGPGGSSIGGIDDNASSLFSGNDNESHRGSLDMGIRPAMANKEGEKPSLSSLGLVSAASRIGVFVDDDLFGDNNKDLPDDGDPDDGPPPDDEDEVHEAAPGDLGLAEAITALSNDIDRLVAQEAVVESLTRKAELTNNTAELRILRKSKASLHREIRRKELQRQQYVIQESDNSLYGRSTIKIKSIQVGREEDGREFALYVVEVQRNAGEQMPAASWVISRRYSEFHELHQKLRSRYPSVRNLDFPRRRMVMKFQSEFLRKRRTALEQYLQDLLLLPEVCRSRELRAFLSQSVITQGQDILDREDKKDMMTRLYDSVADGMDDILGNIPVLDQISEAGQNLIAAATNQLNAVPLNANEDTFPAAEAEAELNAFENKELEPFIKPICDIFLEIFELNKGNNWLRGRAVVVVLQQLLGGTIERKVRDNVKMLVQDENILKYIGLVQDSLWPEGQLQRDRKPRTAAEKKKTRTEASLMLATLVPDLAGSVVGRVNAQTASRRIFATLNNSRLNAHLVFTMIDEIVSVLFEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTD6</accession>
    <name>S0DTD6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pectate lyase</fullName>
            <ecNumber evidence="5">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_04117</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426723.1">
        <property type="nucleotide sequence ID" value="XM_023572635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTD6"/>
    <dbReference type="STRING" id="1279085.S0DTD6"/>
    <dbReference type="GeneID" id="35397598"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04117"/>
    <dbReference type="HOGENOM" id="CLU_021894_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000036">
        <property type="entry name" value="Pectate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013402418" description="pectate lyase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="14">
        <location>
            <begin position="53"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT64642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="328" mass="34291" checksum="AAC613B59846C9C3" modified="2013-09-18" version="1">MKFLGLLNLAALVSAVPTPTFQEAGKTLGKRAAITDAANIGYATQNGGTTGGAGGATVTVSSLAEFSKAAESEGKQVIYVKGQISGNNKIRVKSNKTIVGAAGASLDNIGLYINKQKNVIVRNLKIKNVVAANGDAIGIQKSTNVWVDHCELSSDLSKDKDFYDGLLDVTHASDFVTVSNTHLHDHHKASLVGHSDSNGSEDKGTLHVTYANNHWSSIGSRAPSVRFGFVHVFNNYYEDISVTGVNSRMGAQVLVESTTFSSAKKALTSKDSKETGSISVNDVNLGGSTNDAPKGSISKSNIPYQYSLVGSSKVKSAVVGVAGATLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUH4</accession>
    <name>S0DUH4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_03077</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428161.1">
        <property type="nucleotide sequence ID" value="XM_023574882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUH4"/>
    <dbReference type="STRING" id="1279085.S0DUH4"/>
    <dbReference type="GeneID" id="35396559"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03077"/>
    <dbReference type="HOGENOM" id="CLU_000288_17_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000440">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="617"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="916"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="917"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT66080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="994" mass="113071" checksum="1822D6FA573D429A" modified="2013-09-18" version="1">MENASKPPPRRRHAAMRDEREVNDQGERARHERGMKSSQRSRSPRQVRDSRHDSDTRRNRPLTRPDSHSSRRRRHSHDRSRDRASRLSPEQSRRAPEVEDLIPRYRERHRETEEKPPRRSQSRSPGHDHIGRGSPSAAKRHRSRSPSLTISNRKRSRRNRSPRPRTRDISLESPSRKHARPSSRDRRKSSPRQQARSSKSPTRSRPRSPAKSDSDSRRADREAQSQLDRPLPRSRSRSLTSEHHLASSRRARASSREDQRTSGLGRTSSRRQLPPRSPQASRERRSREGSPGWRHSSRSDIDEDMASRNNLRGGYNPKYHQKSHISNDPYSPSPQHASYHNSPSRSPYGPSRGGWNGHQAYPPQYPQGSSHGPPSGPSSHYHSNATRSPPYAAPTGPMQQYPQGGAYRGGYRGGGFRGRGRGGFKNSHWNSGPPSRGHHDDLGNERFSNVDNHGNTGPEPMDVQEEVFQSHNELGEDTSQVVQDRANPLTTPNRPPPSGPGGSSGSKFSFAFKPSSKPAVTAPKPEISQKLNAAPRREPQPENRDRDRTRDQEREPPRTAPTEPASSRPRHERRHPPEGPRVAPRMRKVTKIMKRPKPRPTLPADLVDSESVFFRKPGNESVVGSGTYGKVFKGLNVYTKGMVALKRIRMEGERDGFPVTAIREIKLLQSLRHVNIVNLQEVMVEKNDCFMVFEYLSHDLTGLLNHPTFKLETAQKKDLAKQMFEGLDYLHTRGVLHRDIKAANILVSNEGVLKIADFGLARFYAKRHQLDYTNRVITIWYRSPELLLGETKYTAAVDVWSAACVMVEIFDRNAIFPGDGTELSQLEKIYNVMGTPNLKDWPNLVDMAWFELLRPTVKRRNVFAEKYRDKMSPAAFDLLSAMFHYDPAKRPSAAQVLQHAYFTEEAPAARQATELATHNDWHEFESKALRKENDRREREAKKLAKENAGRDKEKDKKRINEGTDQRDTKRLQVDKNGGNKPKPAVAPSNSTSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUY8</accession>
    <name>S0DUY8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428351.1">
        <property type="nucleotide sequence ID" value="XM_023575114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUY8"/>
    <dbReference type="STRING" id="1279085.S0DUY8"/>
    <dbReference type="GeneID" id="35396766"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03284"/>
    <dbReference type="HOGENOM" id="CLU_011833_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF5">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="360"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="797" mass="88731" checksum="83517EE4D93D2E78" modified="2013-09-18" version="1">MASVHSRPSPNSSSSYEFESVPDDESWQYIDYTATGSGPSSIGFLSDPASGSLGSFAMVGNVHGTPSPFIPGNTPSPYAAGNTPPPYTSANNSSPFMLGNTPSPTAASPLLLEEMDPSAFFAANASSFQSQPSNTNTDIFASTADGGFTQPQDFLTPQQYFFSQQNTNQFQPQGLNGMLKRRTASPQGQDTDAAADMALMQNFTADMFSIDANEQVQVPQVNFNMQQPLQSDPNVPPWNPTNTRGNDAIFIMDDFNNSPSPVSNYSPSSMNSSKASPSGAKSPVSIPIRKVKVGKVEKKKKAEQSGKFVIVTPNSISAHAGRENPFECFEAMNRTSQRGRKGPLANATKENALQVRRQGACFCCHSRKVKCDLERPCKSCKKLMVQVPQVVCWQFSDFVTILFPVYIRGHLESKAMAKFTRENIAGFHIQGVEQVCSVELFSGPRFSTVLALQAKFFTPTNAEVQNHWQLHNLGQNKVELRANKAANLGIDLEKSAERDNLRKRTKRYIQDLLNEPEFVAQVTDSITSTYLPAKLLRIVKEYADETESLMVKRALSIYCMHYIMTRQLCLTQQTTDSLRSVGMIEQGPNYVTPRVLARQIKSIVDELMHREVQSLFELFNRSLKPKSRREWAPCTAAFLVLCLFMEAVETAADTFVLAQNEINMRNSARPEYERSLALNTCAEVENMPFKQFAYQFHQVYQTHSKEANSKGFNPVLDISFAEKGELDGPAVRFSAQLRELLFGDSWQELQFLAATDMIPNTSTHPFPMDPQTLYTGRLVARFLISFQDERSIFEDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVG7</accession>
    <name>S0DVG7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to ZFR1 regulator of fumonisin biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_03510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428557.1">
        <property type="nucleotide sequence ID" value="XM_023575366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVG7"/>
    <dbReference type="STRING" id="1279085.S0DVG7"/>
    <dbReference type="GeneID" id="35396992"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03510"/>
    <dbReference type="HOGENOM" id="CLU_014095_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000001">
        <property type="entry name" value="Fungal specific transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT66476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="751" mass="84239" checksum="E0C7CDC873EBA529" modified="2013-09-18" version="1">MAENPSPDERVAIDDLTPEEANRIIHSHRKVRYGTACWPCRQRKVKCDNKQPCENCVKREHPRLCSYKPNRSSTSKPSGSGAPSEASQGIASRKRALSFSEAPRDEGVRKVERQDSWPRTLASIDEPEVAADRYVGQNSIPALLREQSSPVHKGDGLDIRQDMRSILGLDTSAPFPLMSSHHLQKLTQDISTELPSDREVMKLFRTYKEIPQPFWGFVMDIDDLEAKLMTYLEDRSRNATSGSKSTKPVTASWLAILFAVLAVGSQYHESPYHIRTRDSQRFIQISFHFLRLGNFLLRPSFDSIQALLLTCFVLLNDMKAEASWALMGLTCRLAQSLGLHRTPRNESRDCTPPNTQAKEMVRRRLWWSVVWHDTLTSLSFDRSPMTNFPCCPIPVMAPTPNGNYSYLETMYHLMEIISRRLNPDDMMSASYSQIIDDCEAVETLRSRTAPQLRNKEICKTALDRLQHYAIRLHTSFVISVACRPALRKDSEFEPEQRKTLADRCKDNLTETVRMFLAMHQLSSIPTRSWAFTYHGLSSALLLGILCETKTDPEVRQLQGDLIAALSATAAKDVSSPEPHVMTTDKDIELSGPLYRALTALKNIYDHGSIVPSHLKKEGDASAAGSGSRTPLNPFGNPGQLPGNGNSMFRNVSQSADPREDAALAMAEMQNGGASIQDFPGLAYGQQMPNGSLNLDSMNAMNVDPTQYMAPMDLYESIWGESPDPWNTGMDSLNFDFLAQPPPGQPQQQFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVN2</accession>
    <name>S0DVN2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427558.1">
        <property type="nucleotide sequence ID" value="XM_023574148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVN2"/>
    <dbReference type="GeneID" id="35395902"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02420"/>
    <dbReference type="HOGENOM" id="CLU_006866_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="854" mass="95942" checksum="1BE8C6EBCB5CD735" modified="2013-09-18" version="1">MAGLKNIMQVSDPSATPLFLLQAKQYEEFGRDVRGLGENLDILSRVVAWADNSLQSQRRQGAPARLRWDRTSLIQIIGDYEMTLRECNELLRSNNRYRVGTNPLRNLEWNVLVQPAADQLRQRIMLHNSKILHVLKPFEVDLLLRVRQDIERMHRDLADRITAAHHDIRRLMGVLIPDLDEALDQRVQRSVILLEVPVDLDEQFRFAALTGHPEYRIEEDFELTELSDAFILNFHKSTINFKSGMVVEERVPTVDQYLNLLKCVWIFKRIQAAPALREADKDTSHWPSYARQLEDDLSSQCARFGRELVTPRIITSTLKRDMFTIWPEKEPAPLVDLVTKDEMMEQLLEVNLQSYSPGIEKKAKLLRRLDADGRRFRIIMSGSAQAASGKPRQQTEKFDFDITTMVFNPQYALPTGSHMTQEIIVRQNERIARLDFMDGADILKFQQAVTGFKPWASATQYDCQVIFVLGGVKETIMENACLQLWIPKSTEGSLVTNSDAAVNNIKTSSSRQNSISTLASGAMPSSPLSGSRPFASPAQTLSSYGNGGDGFAMGPPGRHPSLPTIPQRQPTGPGFYGSWPGRTSPEPIGSSPVERQSFFPIPGPPRQSPPRKPVGSSPSPRRSSSLFPPPSSTTTMTNNGRSFSISSGVSSNSNSSNSDVRSVSISTGTNSTGLLHKRPVKPMLVLFTQNRQGDKFSFVTVQIDDETNMNPERCNCRRSGRDGASCDIAAIEKKKGDAPISARRYEQSPSDGEMDWNLARLALNNPASTSDSVNWPNLKRLSIKFPTPQARAKFCGTPNVCHCKIKKEGDLLKCIQERHRGLWGEVQENYRRQMNSFHKQRYESRSHVVYGVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DW48</accession>
    <name>S0DW48_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426799.1">
        <property type="nucleotide sequence ID" value="XM_023572727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DW48"/>
    <dbReference type="STRING" id="1279085.S0DW48"/>
    <dbReference type="GeneID" id="35397515"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04034"/>
    <dbReference type="HOGENOM" id="CLU_059021_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="122"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="305" mass="33508" checksum="FCF08962212BC958" modified="2013-09-18" version="1">MTRVLATFRSAIESRPSTLHARKCLITAPSSSTMRLNSSAATAAKPAFSAVQPIANFEETIARRPDFDHSGKPIEITKSPDPSWSYGDGVRTGQSPTDKIHREIDPYSPDRSVGQNYRLLISGIAPRPVGFISTISGDGETKNLAPFSYFQVIDHDPPMFIISFSSRFGSAKDTYQNLKDTGECVINTVSENMIEAVNASSIDAPYGVSEWDITGLTEAQTTTVKPSRVKESVLSIEGQVVDIKEFESHKPGMSNYGMVLIKATRFWVQEDAANEDFSHIELDKLRPIGQLGERDGPMSNPEVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWU1</accession>
    <name>S0DWU1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_13101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429011.1">
        <property type="nucleotide sequence ID" value="XM_023575746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWU1"/>
    <dbReference type="STRING" id="1279085.S0DWU1"/>
    <dbReference type="GeneID" id="35406556"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13101"/>
    <dbReference type="HOGENOM" id="CLU_012437_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070199">
        <property type="term" value="P:establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="590"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT66930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="659" mass="74659" checksum="77CEE3417FC4FDB4" modified="2013-09-18" version="1">MKRFSQRVLSRGKDPNKSSKKNKDSKDGTASPSSRDSNQSPVLTPSSSTSTLNDPRNKPLPQNNAGHGGEHGSGSQPSNLSNVTQAGSTPDRFATGGASSPNGGSASSRLPPTVVISPTPGHVPPPGAAETMPHDLAPPKAGQKSLLIHRGIDNRDAIPEGLRTPKRQHSSRFDISAHRELEKLPGFHEVPPNRRQELFMQKIDQCNVIFDFNDASGDMKSKEIKRLALHELLDYVANNRQVITEPMYPKVVDMFAKNLFRPIPPPMNPQGEAFDPEEDEPVLEVAWPHIQVVYEFFLRFIESQDFNTNIAKAYIDHSFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLNLRSFIRRSINNVFFQFTYETERFNGIAELLEILGSIINGFALPLKEEHKIFLTRVLLPLHKPKSLSMYHPQLAYCIVQFLEKDASLTEDVVLGLLRYWPKVNSTKEVMFLNEVEDIFEVMDPAEFAKVQEPLFHQLAKSVASPHFQVAERALYFWNNEYFCNLVSDNVEIILPIMFAPLYENSKGHWNRTIHGMVYNAMKLFMEINPQLFDDCSHDYTEQQNSAAAREALRERKWAALSEKANQQRESNGNGTAEAPSAQNHVNPMPRVDEVDPQTEDNSKRLDSLKLQDGRPNLHERQESVGSTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWV0</accession>
    <name>S0DWV0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429021.1">
        <property type="nucleotide sequence ID" value="XM_023575759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWV0"/>
    <dbReference type="GeneID" id="35406568"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13113"/>
    <dbReference type="HOGENOM" id="CLU_152686_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495303" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="42"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18393" checksum="2ED6275FA91FB7B3" modified="2013-09-18" version="1">MSQKSPGYTAPPTTITSKYSYPVKIMHSLLVLVSLLSLTTASHVSRSAPDTDGEYSWDCGHMAPFSVSDCNELLDWFKTISKTGWFGIGKANGLAKYWGSCQLYIQPGPLGYFALEIQQDEFVGVVRQGLVDKCPDKLTRTTVKPNNNTWVAYVTEKGWEPRNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXP1</accession>
    <name>S0DXP1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429415.1">
        <property type="nucleotide sequence ID" value="XM_023576236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXP1"/>
    <dbReference type="GeneID" id="35406993"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13539"/>
    <dbReference type="HOGENOM" id="CLU_531042_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="516" mass="56979" checksum="CC1DA33F1084B58B" modified="2013-09-18" version="1">MPNPLKAIHASFNLLTWALDHDQVPNDIRRSLELVRTCDSDLQHLIELRQECLHLLQRRPKVLERVHSIIESAQRGLQEVCEIVERCRPEADRGGKTTFSKRMAWVLVDASEFKSQEPIVSRHHAAVLAELNFLRQIALLAPVPEPVKVKEKRGVRDEAAVFDNVALLGDLLGDATGKKPQIVQSIDAPTPTIVFNTNAESATPTTQSLLQVPQSLHRSTSSQTMHIEHASESLPELVPVNMNSTALPKSFTSSATYDTEALAGLSLLLGDPLDWRHSPPLAPANNGQLNRPVTAPSQRRLAHFTNNDSDQHLPLHSPYDSVSDLSQTSQRASLNYTPSRLSPSISSPYHQHHSLSRPPAATRSASQLHHMPSGHYPGQLTWSNSSSATISSISSGVTSLDYSRIPPIAELDSSPHHMVPIVGALSHLNRPNEVPMDQKLAIQINTTPVELPAEENLSTNINPYCQTFRPGSNRRGRAISQPTSTLHQQITRKSTLNQGKEVVRDYNGVPKDYATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXW9</accession>
    <name>S0DXW9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428313.1">
        <property type="nucleotide sequence ID" value="XM_023575067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXW9"/>
    <dbReference type="STRING" id="1279085.S0DXW9"/>
    <dbReference type="GeneID" id="35396724"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03242"/>
    <dbReference type="HOGENOM" id="CLU_021599_8_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="527" mass="58208" checksum="7FB9A527A1ED7831" modified="2013-09-18" version="1">MVGVPRSTGCRLCRTRKVKCDTLKPSCGNCIKYGAECPGYSRGLKFVDEKHQIRQRGRRQGKSEQVSTSSSSSTTGSDIAISDSETWSLVRPSPTLLRLELPRGPLLLNMIESSTNYTRSTDVFILLSWLNIDRLGKRALLDGAICSFALHLTGKANSNADLVAKSRTIYGLALTELQAALQHSTEWKASETLCAAILLCYFELFAGTAVPDTWIQHAKGIGTLMEQRGPAAHAEGWDAAMLLSCRGILVCPTFLLDYCNKAKDKELALSPGQVTELCECLPTISDMFYPGKDQLFLSRPAWRHVTSDGGRRLIYAPDAPIEHIRVGDGFLANLAQLTPILHGAYLLREANKAGMFVEPDKISALAHLATVEHARFARWFDDFDVLEFPRPVEVLPTDPANSLFGTVLEHKSAAAGSLLLGYWASMLILEETLVECGTPRANSEISIRYFVERILRSVESVGRGTMGPYRIGFAIRIVYEFATGQEQRWIASMLDKFSQGYAAIDKKTYPKPKDDDAQPTRFVQSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY15</accession>
    <name>S0DY15_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED10</name>
        <name evidence="11" type="ORF">FFUJ_03307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY15"/>
    <dbReference type="STRING" id="1279085.S0DY15"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03307"/>
    <dbReference type="HOGENOM" id="CLU_096169_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF13">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT66292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="167" mass="18454" checksum="B0D6E55115716A88" modified="2013-09-18" version="1">MAPVDRVDHNALEQQLKDIIQDLYQIMVQVSTYDSVGRSSREVLINEIKTLSDSLRTVHSSASPPNNLPSVPPELVEYVEHGRNPDIYTREFVELVRRGNQLMRGKLNAFGTFRDILAENITTAMPELRDDVAQVVEATGGVPPGRRNGEQSQQNGNATNHASSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY24</accession>
    <name>S0DY24_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_13562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429436.1">
        <property type="nucleotide sequence ID" value="XM_023576261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY24"/>
    <dbReference type="STRING" id="1279085.S0DY24"/>
    <dbReference type="GeneID" id="35407016"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13562"/>
    <dbReference type="HOGENOM" id="CLU_009024_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000174">
        <property type="entry name" value="YIR007W-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="65"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="642"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="768" mass="86922" checksum="3CC99BBBAB4F5D43" modified="2013-09-18" version="1">MSSFRLLIEDGQFRDGYGRQVVLRGINLAADAKLPSEPDQPSHIPTDFFDGDNVSFHQRPFPKEDARSHFARLRRYGFNTIRYIFTWEALEAAGPGKYDEDFIQHTIDVLRIAKEYGFYIFMDPHQDVWSRFTGGSGAPLWTIYACGLNPQSFAATEAAIVQNTYPNPDEFPKMIWSTNYYRLAAGTIFTMFFAGKDFAPKCIIDGVNIQDYLQDHFMRACGQLAQRIHEAGDLEEVVVIGWESMNEPNKGMTGYKDLTVIPKEHPLKKGTCPTMWQTLLTGMGRACEVDTWEMGGLGPYKTGTTLVDPHGEVAWLPADYDDSRYGWKRDPGWKLGKCVWAQHGVWDMETDTLLRKDYFAKNPNTGKVIDYPQFTNTYFMDFWRKYVKTCRALHKDCIMLMQFPTLELPPEIKGTEDEDPRMAFTPHYYDGITLMTKHWNSTWNVDVVGVLRGKYWHPALAIRIGETAIRNCLRDQLATLRQEGLDRIGKHPCVLSEFGIPYDMDDKKAYKTGDYSSQSAAMDANYFAVEGSQIEGHCLWTYCARNDHLRGDFWNGEDLSILSLDDKPLPESPVPEYSQSSLDLARTATTANTKKDVADDRNVTPDNLKRTLTNPSISSAPSAKDPQLTNAPGFRAAEAFVRPTPTVVYGDIVSTGFDLRQCTYLLKVKAPKAAPDEAPTIVYLPEYHFPKEQCEVAVSSGKWELSTDDEEGTTLQKLKWWHAEGEQSLKISGLVRKHNVPVGSEEDAGYLEQCQQGYGFNFGSCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY38</accession>
    <name>S0DY38_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">(S)-ureidoglycine aminohydrolase cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427454.1">
        <property type="nucleotide sequence ID" value="XM_023574026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY38"/>
    <dbReference type="GeneID" id="35395793"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02311"/>
    <dbReference type="HOGENOM" id="CLU_1001327_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40943:SF1">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40943">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="1">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="1">
        <location>
            <begin position="215"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="274" mass="29586" checksum="BF3D8650C14F9123" modified="2013-09-18" version="1">MGSVHQLEHGSRSTTGTWVPFDWEDPVYGQQSKGEVVVIRSGGTSGSLSAGLWRTGPGIPGCNEDGTCDVVYSAPLGDETMLLLEGSTEVTIKSTGKKYQLRAGDIICHPKYVQLSWHTSAPFLKKFWVMWDGSTPGSAKDDLIIGNINDNPQVWTSYAWDEPGKGQQQAGEFHLIRDTGSTGTLEVGLWRTGRGMPGCDSDGSVSFEYSAPIGDETIMLLEGLVTITEHDTGKTLKFQAGDIIALPSGLKVTWTSEAPFVKTYYVLTSDKSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY70</accession>
    <name>S0DY70_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin-sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429575.1">
        <property type="nucleotide sequence ID" value="XM_023576425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY70"/>
    <dbReference type="GeneID" id="35407164"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13710"/>
    <dbReference type="HOGENOM" id="CLU_063074_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="268" mass="30270" checksum="A9BB56655B3F9E7A" modified="2013-09-18" version="1">MTSRPMKHIDREDLYTNLEARVQYLHSFLDFSSRDIEALITGAKYVKALIPAVVNIVYKKLLQYDITARAFTTRSTSFEGPLDEVPDENSPQILHRKMFLRAYLMKLCSDPSKMEFWEYLDKVGMMHVGLGRKHPLHIEYVHLGVCLGFIQDIMTEAILSHPRLHIQRKTALVKALNKVIWIQNDLMAKWHVKDGAEFETGDSDIEIEREGYLHGKRILGEGSGSGTEDDASEHPQNPPSRIPHPSGMPAGGVCPFSGMGAPAEDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYC4</accession>
    <name>S0DYC4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427549.1">
        <property type="nucleotide sequence ID" value="XM_023574137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYC4"/>
    <dbReference type="STRING" id="1279085.S0DYC4"/>
    <dbReference type="GeneID" id="35395893"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02411"/>
    <dbReference type="HOGENOM" id="CLU_027502_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="57909" checksum="3DA1D8E88D5AAB3E" modified="2013-09-18" version="1">MIGTSFGEWVFIRLSIAFFRYTPLIYIFLILFLPLIQPVSVVFPFACVLLAALLAEVVFYLFMYRPYLQRLKRDAAHPPALSRQDRNALFERCFGNVPSLEIYLRWWFLDADPKEIRRGNVREFILWAFFERGDGSGLVDDEEAVEEEVEHYLSLVEQRLGRKFEEGRGHVKSLRLTIDGITTTYRSLVWYIIVFFLDQATHLAFRWHGFDFHRRPRSSALRVFPPRPQELFPGPKSPSTRLSYWHRPHTAEDKLPVVFFHGIGIGLWTYVRFLAGLHKTGDGNGSVGVIALEILPISFRLTPAILDKAEFLAHMTSILEHHCWHKFALVSHSYGSVLTTHMLHEPNFQHRVPSVVLIDPVTIMLHLPDVAYNFTRRKPRRANEWQLWYFASTDPGVALCLGRHFFWRENILWKEDLLGTQSDGHHARHVAVTLSGRDLIVDTTAVAEYLGVDLSSGRNGMVAESHNGVEVVMFPKLDHAQVFDDRVSRESVIQMVRSRCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZC4</accession>
    <name>S0DZC4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to TMA16 Protein putative involved in cytoplasmic ribosome function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427914.1">
        <property type="nucleotide sequence ID" value="XM_023574587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZC4"/>
    <dbReference type="STRING" id="1279085.S0DZC4"/>
    <dbReference type="GeneID" id="35396293"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02811"/>
    <dbReference type="HOGENOM" id="CLU_106785_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="183" mass="21092" checksum="0A7DD4B3AFBC14D4" modified="2013-09-18" version="1">MPTTLHKTRKQISKKRNGVVNALHEKSRDSMRLHKAGVRDQRIEKLAAARSKKEQPLVDRVAFFQQALRLKDRDSKGAPEIDEVQRMIHSFVHQYDEEYNETKKTRRPGRPASVKEDLLKAKINILEEEYKSGFVMPDLLDNANVNALHLWEGSWSYLTQLKWVKVNSEGKVRPTSFPSGGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E055</accession>
    <name>S0E055_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430271.1">
        <property type="nucleotide sequence ID" value="XM_023577159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E055"/>
    <dbReference type="STRING" id="1279085.S0E055"/>
    <dbReference type="GeneID" id="35400437"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06960"/>
    <dbReference type="HOGENOM" id="CLU_111225_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="136" mass="15771" checksum="286D4B4E3E18D682" modified="2013-09-18" version="1">MYRENHPGPLSLPGMWSPPSDEAIPLPKQSHHDNHRSRQASTCSERSCEGMSLDETRELWRCMLELQLRYGCYNSTRIDMAIDAGECGVDLMPNRFIIDTLNESVIDLPDEGRELLNRYLCPSSPTKQKWKFWKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E067</accession>
    <name>S0E067_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to DUF1264 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430286.1">
        <property type="nucleotide sequence ID" value="XM_023577178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E067"/>
    <dbReference type="STRING" id="1279085.S0E067"/>
    <dbReference type="GeneID" id="35400454"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06977"/>
    <dbReference type="HOGENOM" id="CLU_071931_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="244" mass="27989" checksum="3B2643A5634C53D3" modified="2013-09-18" version="1">MAEEKKIPVTNEGMGNPLSAKNQVLTAGAAVTQEFRPVKHICAHLNAFHAYADDPSRFVETNHYCAHLSTSLTNRSTRSLTPADEDVRQCLLYDSDEPNARLIGIEYMINPKLYETLDKEERKLWHSHVYEVKSGMLIMPNRAVPESAWQVAENYEMNQVVQLYGKVYHLWQTDRGDTLPLGEPKLMTSFTGDGQFDFEKHVGERDWKFGTDWRVKKEARKDIPSPAVHEGEYEWSTRDCANDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0M7</accession>
    <name>S0E0M7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430426.1">
        <property type="nucleotide sequence ID" value="XM_023577341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0M7"/>
    <dbReference type="STRING" id="1279085.S0E0M7"/>
    <dbReference type="GeneID" id="35400600"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07123"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="331" mass="35998" checksum="6A98147023380828" modified="2013-09-18" version="1">MSSPKLITVFGATGSQGGSVVQSLLQNKSQSFRIRGITRNPESEKAKALAEHGVEVVKADGLVKGEVIEAFRGSWGVFANTNSDDPSMNQEDGPTELDIGKSLVDAAAEAGVRHFVHSGMASASETTGGAVPNKAFDMKHAVGEYAKSRGFETVNVVSPGWYLENHLVEEFAPALGGFPFTTDEESYLTLRVPRWGGNEEIPFISIGDDYGDLVHGIFLDPKKHNGRLVQGISASETTEKLVSEFEKVTGKKARFVPIEDWTTMETYGDQSFETVKYMFGFCQYSDGLYYGVPNDMIPATELKAKAAEAKGQSGDAKLMTLEGFWEKYFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0U1</accession>
    <name>S0E0U1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional regulatory protein RXT3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430355.1">
        <property type="nucleotide sequence ID" value="XM_023577257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0U1"/>
    <dbReference type="STRING" id="1279085.S0E0U1"/>
    <dbReference type="GeneID" id="35400525"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07048"/>
    <dbReference type="HOGENOM" id="CLU_005227_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1142" mass="125286" checksum="9182B4FB4B0CA548" modified="2013-09-18" version="1">MDPRHPPKLPFSPSPYAIVSPFPQVPVPVPVPVPNPNSAPFPASPTTTKQPSSTPNGAITISSAGSAPATATAAVFYPIASPPPHSYRIARAESYHHPHAENLSPDQNPAYAAPHSLAQRRPSDTSIYAPTIRHTSHESNHARFRNSTAINSLGTLNREMPPPTSPPQPGAKPPQPQPQQVHSMMGYGPPPPQPGPPVAVGPPMSFPSGRELPALGALARSGSSNSSMSISSMLGGPPPAMRESQPPPSHYPPHSGPPVSGPGFATAMHASPRMHSANSSYPPFRRPHTPDHQRPYEPRNSPPGHYPTPEVPRYSTPSAYSRHPSGSADHAREPSRLPPGPPPRPSSQPKYPGMPRPMEMGRPPGPEEAYGRRDEMGRPPPGMEYNPERVGLRPNPYEDRYRAERERMGEVEQRERDRRERAYSGSDSGRHSIHPGDYGHREPPRNPLPYGRPPDRDPRDIRDPRDSRDPQNRDPRDMRERDPRDAQWGRPGPDPSYRAPMDHQRHPDYPPGAPYPPHGHSYQGPPPDRYAPSSHPPAQNMPPGPAPYESPDRARMTLIPTQQPQQPHRRPEEGPPPPTIAYNGAHGPGQYDSPRHRNSDDASAPNGQRNLLAIQEMNRKGRISPLPQAVQGAQLQQPGPTGEPGIKSEFGRMFAGIGNGVMGVSSPIASAAMPFTNASLAKREDSENITPDSGTEAGGKATKGRRRKLKDDDGKGDDDSSGRATPANRAKRPKTHQHHHHHHHPHHHHHHPADSAPLTGTAPFKNFKTGAPPPGEKGLPVPHHHHPPRPVHTHQHQPAKQAAMNSAPVIPPKSKTIISSKAVLESVSDRPRHHLGDFIYDPGLKPGRLVPSTSTHRAFASNPKPLPWDMIKNKENCILTVKVARIHLSPIAREEITSRGYLWGTDVYTDDSDVVAACIHSGWIKGEWAEDVDNSVLDIDQGVTDKRRKKPANSTVDLESEDLIIAPPPSGPMSIPAQRDLHVNVLILPRLVKYYSSTRHGISSREFGGDYGHRHSVHDGISYMIKSVRWVENGAQPQARLRGKARRERMRKAMREVKWGVDNGTDLDKDKEGQLRGGISATWRKKEPEPSTSKSNDPVAEGDKENQPSANDEEKEKSEEKAKDVDMDDVAETPATEEKTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0X7</accession>
    <name>S0E0X7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF726 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_13519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429398.1">
        <property type="nucleotide sequence ID" value="XM_023576213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0X7"/>
    <dbReference type="STRING" id="1279085.S0E0X7"/>
    <dbReference type="GeneID" id="35406973"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13519"/>
    <dbReference type="HOGENOM" id="CLU_007407_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT67317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="71806" checksum="4B786B85D480E097" modified="2013-09-18" version="1">MARGGRGSPVPRRPVDLTGVISIAEKNDLNTLITAITEKLHNDISVIFDSPPVTPTLGDLGDIGHHHWLALSLKTNGKENVKPRAPSICKPVAKVSQKTADTSQSPDTENSENSMPQLRELKKEALIFFRKWQSIFLQRLRDISVMESNGSQSNSRGRGRGTARAVRGGRVARGGRGGGRGGTGGVEGLTLATGGLTQVPWRTPRTPSNHVDRELSRRFPPVPTSLWTLPLDKRKLLLHISLLILISLQEYTAYARMTLLNLTSSLNLPLKVLHEEEKRIAEGFSQLAVDAAIEQASEPDQDENKPVLKSKARIAAMTGPFRLGTQLIAVGIGTPHGGLGLRLPNAAGLLGPMADNGPSTGSMLGIYMARPTEKMIESFSRDIQDFGLVPTRGGLQGDYVDAKAIPASCRRLRLVIAMNGWVTDKDNLIGPWKILGDNGEVYVLRWEMNVLNNIGTALETVVKSSAWAAAKKAISSRTIFTSLIEATWPMELMKVSKIIDNPWSMGMVRAEKTGAVLADAVMRSKIQGDRPVSLIGFSLAARAIYVCLMILAERRQFGLIDSVVLMGTPAPSESRVWLTLKSVVSGRLINVFSESDYLLGFLYRTSNIHFGVAGLQRIQGADGVENHDVSNLVNGHLRYSTLVGKILKDIHWEDLDLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E265</accession>
    <name>S0E265_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to diaminopropionate ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_07761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431014.1">
        <property type="nucleotide sequence ID" value="XM_023578049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E265"/>
    <dbReference type="STRING" id="1279085.S0E265"/>
    <dbReference type="GeneID" id="35401238"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07761"/>
    <dbReference type="HOGENOM" id="CLU_021802_2_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF32">
        <property type="entry name" value="ARGE_DAPE-RELATED DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="192"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT68934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="443" mass="48037" checksum="8258C11E7CADDD55" modified="2013-09-18" version="1">MPQKQSFLQALAADEHNQTSFLQKFVQAASPNPPGDTIKATAVIGGYLSSKNIPYEFFDVNGDGKVNVISDFQGRKGPGPRVVLNGHVDVFPVGDGSGWSRDPWSGDIVDGRLHGRGVVDMKSGTASLIIAYAFLYERRHLLSGSVALCAVADEETGGKWGTKYLIEQDKHRWGGDLMLCAEPGGLETIRFAEKGTLRLTCAVKTKGALGPYLHLSKGAIRTASAFINEVIESVEALPVDLPVEMERHLEKPEVKRAVDQAMGPGTTTIIARPTVNVGTIQGGLKVNMIPETCIVELDIRMPVGMREDTILDLIDTIIPQHEPASITIKKQAAASNPFNYSVIDHPIIGHLKDNAKSLRPDSDSPIPIPSMGGSDCKHYRYAGIPAYIFGCSPDTSEYFLLNKSESFIDGSPVASVDESASIAEFHHVTKVHALAVWDYLHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E383</accession>
    <name>S0E383_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_07888</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431394.1">
        <property type="nucleotide sequence ID" value="XM_023578191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E383"/>
    <dbReference type="STRING" id="1279085.S0E383"/>
    <dbReference type="GeneID" id="35401365"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07888"/>
    <dbReference type="HOGENOM" id="CLU_000288_172_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT69314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="634" mass="71614" checksum="A8A424402F1F8EED" modified="2013-09-18" version="1">MECLKDKFVGGALLKGRYQTISPLNHGSFGMVFKAQDLVTNEPVAIKCLTKRSACPDADSDFAIDEKSEEQALHSRLGTHRNIVNLIDSFETDSHIYLVLEFCGQGDLYEAIRKGHGPLETEHVRQFMIELIDAVDYMHSKGVYHRDIKPENIFLTQDGAMKLGDFGLATTEKWSYEMTVGSDRYMAPEQFDSAGAGYSPAEADIWAIGICLLNILFSRNPFTTPTEADPLFLDYSRDKQSLFDVFPSMSQDTYEVLVQCMNLDPRRRSLEGAREALLRVVTFTTDDEDDDEYCGAESPNVATANREPLRTPSIQSPAVDTGAFPWAKALHGTTHLGRQLSVIPDDESYTEELFPKSEATTTDWCSANMQTPMSSVYDSHLGASMKSLAIKPTARFNRSSATAGSLPINMAKPMPAMSMVFGRRQETVSKSWSDMWDEDEEEEEMEQQRQMLQELNARTWSQESKEEKKVVEEEEQAMKVDTAQPESEPASHTHDIKGDVDDDLVADGFFFQEAPTPKPQQITITPHYSQSPMSKPKSSLDKWAALGERRRGQTAALDSIKSVDFSKPRRHNFGFGYNKSYEAGVWDHSNYHHKFGAAKERSNSKECPWNKGRDWNWRRDRRTDLGDVEWVGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3G1</accession>
    <name>S0E3G1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429329.1">
        <property type="nucleotide sequence ID" value="XM_023576131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3G1"/>
    <dbReference type="STRING" id="1279085.S0E3G1"/>
    <dbReference type="GeneID" id="35406898"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13444"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="263" mass="28937" checksum="E9F5A9F651CFC78C" modified="2013-09-18" version="1">MFRNNYDNDSVTFSPQGRIFQIEYAAEAVKQGSVVVGIASKTHAVLCAVKRNAEELSSYQKKLFTVDEHAGIAIAGLTSDARVLSNFMKQQCLGHRLTYGRAIPLRSLVDMIGEKAQMNTQMYGKRPYGVGLLVAGVDERGPHLFEFQPSGMTEEMLAFAIGARSQMARTYLERNIDEFADCSREELVKHGLKALKESLVQDKELTVENTSVGVVGINTKDGKKKVEPFKLYDGFEVQPWIESVGEGQGGAEEGEGEGMDVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4F8</accession>
    <name>S0E4F8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431610.1">
        <property type="nucleotide sequence ID" value="XM_023578631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4F8"/>
    <dbReference type="STRING" id="1279085.S0E4F8"/>
    <dbReference type="GeneID" id="35398901"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05422"/>
    <dbReference type="HOGENOM" id="CLU_036330_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF17">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="436" mass="48682" checksum="CB69864E8C3BF52C" modified="2013-09-18" version="1">MPRQKGKGCSICSRRRIICDLGQPSCQKCLGRGFACPGYGPRLRWVQGVALRGHLRGIQFPIPESPASDSSPSLDNNTQQLLDYYDKNIAGLMVWIDSEKNYYRQKVLPLAQTNEAVRLAICAVSAQHAARDFTPSTVYEKDRDHVLSMIMQGVDDMTAHPQLTVTADTAEWMLSSMMVLSSYELAHAGGAEAADFHRKAARALVNTLSTLDFPKSSLFNFLQNQLSMYDIFACTTIFDTTDVQDAIRPIEFGEDRSFSAYLLLLRDVTLISRSGSAQGPTRDWRGEFVQARGETLMEVGSSGLCSSADRGDFIRLVDAYHNAALLYTARCLGHQCCPEETVSLLDLFQLLTGMENLHACIHNLAWPIFIAGTECYGDDDRQLIVRDLYQSLSDVTGFKHHGDVLTFLETFWSGRDPDWRVLANQWEGLGRRILAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4P2</accession>
    <name>S0E4P2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable aldehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_05626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431801.1">
        <property type="nucleotide sequence ID" value="XM_023578858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4P2"/>
    <dbReference type="STRING" id="1279085.S0E4P2"/>
    <dbReference type="GeneID" id="35399105"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05626"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="326" mass="35843" checksum="0B11BC5232D09454" modified="2013-09-18" version="1">MAPSSFKLNTGQEIPALGLGTWQSPAGEVEKAVTYALKDGYKLIDCAYCYGNEEEVGAGLKAAFEAGVKREDIFVVTKVWATYNTRPELGLDKSLKALGLDYVDLFLVHWPLLLNPEGNDDKFPKKADGSRDVIRDYNHVDGWKLMEKLPATGKTRGVGVCNYSKKYLEELLPHATIIPAVNQIENHPSLPQQEIVDFCKEKGIHIEAYSPFGSTGGPVMTAEPVVKIAEKKGVSASTVLLSYHGKSHEPDSEKCVANSLLVARGSTVLAKSVTPERITANKTIVDLDDEDMKDLNDYSEDLVKKGEVKRYVYPPFGIDFGFPDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5D8</accession>
    <name>S0E5D8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_06035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432173.1">
        <property type="nucleotide sequence ID" value="XM_023579314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5D8"/>
    <dbReference type="STRING" id="1279085.S0E5D8"/>
    <dbReference type="GeneID" id="35399513"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06035"/>
    <dbReference type="HOGENOM" id="CLU_043048_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT70094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33125" checksum="1BA1376FFD12F670" modified="2013-09-18" version="1">MKTQQEYDVSLILAMPRSNPNVERGNFMITLHMVDTQADAGLHAAAERHASLHQGLEGANVLFTSRRPALFPYVDPLVSVASRVLFLLYHLFTPGSSTNSIVIPLAERVLFSKASDLPRSAYVEVEAGQTIQIYHAYLQLTAQLRGLRWMMVHYRISTFIALTLVFWAFEVIFMGVAWGLWSMTSGSPPGDADDKTRRLEAEGYEYEDEDTDRAETFPTYGRQQPLKYEPDIKPEADPEQPLSEIPRAGADADDEDEGSFDDDDDDVQHKDSGIGTSYSEEGVSSIRRRTSRNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5J6</accession>
    <name>S0E5J6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GMP synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
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        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
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            <end position="129"/>
        </location>
    </feature>
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            <begin position="183"/>
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        </location>
    </feature>
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            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
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            <end position="262"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT68982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="42801" checksum="38A84DDA83417F4D" modified="2013-09-18" version="1">MSKYKDIMKNGWHPEKPGSSLKGQVKGLVGRGKSEDEDRGSHVSVPLSQLKDPSSFAPPPKRTGSGLLPPPPKAESAPRKVITAPSKYQDPRAPAPQEPVHAEPEEEYEEQPQHRGPYRTNTTGLSTDNLPKPPGRRDGADGRSGQPPSYQSAMAGVGGGGRAAPPSLPPRLPPRTNSGSTIASSPAASPAPTGNGLLNQGAVNRLGAAGISVPGFGIGRSSPAAEASPSPPQPPRPGVASPPPAPAASHMSELQNRFSKLGTSSSASTAPPPPPSEGTTWAQKQAALKTASSFQKDPSSVSLSDARAAASTANNFRQRHGEQVAAGAKTANNLNQKYGLLDKAQNSYSRFQGNQTQSQNEETPSAPASPGLASVVGKKKPPPPPPKKKPALLGASAAPANDEPPPIPMATRPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5U0</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">FFUJ_05976</name>
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        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
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            <taxon>Sordariomycetes</taxon>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="127" mass="13747" checksum="5519F8BAD88901DA" modified="2013-09-18" version="1">MASRISRRFLSTTARRFQEHQKAELKKESRRNPEILILGGVMVAALGGAGYYLGRSPTGATSESPVTIATHPWESGSSGKYQYHPGGDPNAAPKDAPSALNVVVVPNVTLPAELHEKYNKWGKDGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5Y1</accession>
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            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_06157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
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                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
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            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
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        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023579449.1"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_109098_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
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    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT70206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="158" mass="17759" checksum="264DB180B93040AA" modified="2013-09-18" version="1">MPKNKGKGGKNRRRGTKENDDQRRELTFKEDGQEYAQVVKMLGNGRLEALCFDGSKRLANIRGKMRKKVWINQGDIILLSLRDFQDNKGDVILKYTADEARTLKSYGELPENAKINETDSFGQGEDGEAYFEFGDADSDDESDDGAAGNKKEVDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0E616</accession>
    <name>S0E616_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable endopeptidase K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_06749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT67998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430078.1">
        <property type="nucleotide sequence ID" value="XM_023576924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E616"/>
    <dbReference type="STRING" id="1279085.S0E616"/>
    <dbReference type="GeneID" id="35400226"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06749"/>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495605" evidence="8">
        <location>
            <begin position="20"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="160"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT67998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="413" mass="43269" checksum="6677E5BA36B9D2BE" modified="2013-09-18" version="1">MKPALFLFSLAELVRLTLAQVKVQNANIEPELVVPDSYIIKYKPKVSSSSKKKHEEVIHKKAKSKGKEGIVENIDLDGFKGYVAEIPSSELREVIDSDLVDYIEQDTIVNVSAVAAPSSGPITKRGLASQASAPWGLARISQVYSKKGVDARYNYDSTAGSGSTVYVLDSGIRTTHKEFGGRALWGTNFVSGSPDTDELGHGTHVAGIVGGKTYGVAKGCRMYAVKVIDKDGLSSMSTTLQGLQWAVNHAKSRGITKKSIINASLGGPYTKIGNDAVKAATDLGITIVAAAGNDGSDAANYSPGSAPSAITVGAIDSSGYRTMWSNYGKVVDIFAPGSDILSAGHMSDSSSLYMSGTSMAAPHVAGLAAYFMAKEGLRGSSAVTKRIIGAADTSGVYYAFDSPQRVAYNGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6F5</accession>
    <name>S0E6F5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-dependent oxidoreductase-like enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432475.1">
        <property type="nucleotide sequence ID" value="XM_023579682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6F5"/>
    <dbReference type="STRING" id="1279085.S0E6F5"/>
    <dbReference type="GeneID" id="35399842"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06365"/>
    <dbReference type="HOGENOM" id="CLU_018105_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="62349" checksum="D614AC32D1563A13" modified="2013-09-18" version="1">MTSPTEAAQASQTSQGDTIVVRHPRERQNPTTPQPQEAGPQDPAAVTLPSTEIPNSPIDSNESFRTEINEDRPAVTVIPSSLTPPPSTQINSHASQAGPGPSKRKFSGSQQSSTLFSPPATVPNNVRERPVTTEFLPPAPHQVLEASADELRVMLQAALAEQQKLKMETAHHKLQYNLLSIQADDDAKRAAVEHEMMRREVDALRNAEFTRMARKEFDQPSEALQTKYLQMKTRYEAMLQENEILQRRVQTAKKVIKQSEDESIALHEERDMLLRRIRENREHMQMLCRPGGIFHAVLTPRQKVSAVTQGHRNSQQQTSRSQGEHGLSALLQAMSQDNNSAPSTPMHSHRPAPRVGKHHRNSQSMSSLPTTPMNRPVGTNVGLLPSVDLVPHSEPHRYSQRQFIPTTPVAKTDRRRRSRESTISADDNEELARQALESVAAAQSFTSQSRNRSDQDGEVFDSQASQAAAEMLRRDPRQSFEVAETLRNTPGPMEKTVRMQERFLSHRNGDGDKRKFSGNHSSTEEIRLNQASPAKKSKVVEPVADGQDKLGLGIQYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6G3</accession>
    <name>S0E6G3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_06230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432354.1">
        <property type="nucleotide sequence ID" value="XM_023579532.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E6G3"/>
    <dbReference type="GeneID" id="35399707"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06230"/>
    <dbReference type="HOGENOM" id="CLU_001366_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8 12" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="10">
        <location>
            <begin position="481"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="11">
        <location>
            <begin position="1073"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1290"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1299"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1336"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT70275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1376" mass="156234" checksum="CF8707C480B4288B" modified="2013-09-18" version="1">MSSKRPPDGLSRGFQQTPKHQRRSKRCRPGKPKVRRNHAVNIDGLAPQLHEQWKAWPELTIHLEGLPTSVTTSNLWDWFSHEGEIAYMDIYETQRNPNISNAKIRFEPPPERNFWYTGSYIVRHHDRKQHPKEIEISIKLSNHVPPGFLKSPVHPDRTCPVKLTLYPAAIHFGSLTGENSMKIMKSIPGMGNGRSLKLEVNPKYQRLTAFFPVPSVVGGNRTERQHKVVIDFASMKNVYQTATADNCCTFVVPLKIPPQYYWKAPNIHLTFSDEAKNWSVMESWNRATNIVQHAGLPMMHPVTLHNDFQDPEFVDIGRWTTIGFVLDGGTEIASQVNQQLVTILDDFNISTKVQDDFKTVDGTKAKMWEYIDHQAPTEGHNALQMLQYSRDSVIHLPFDIRYQLEVCLSRGYLNEHMIEREFLERLANMKPAKARLCLETVADNAQVVVDPMAILEESQLDGSIIMSRVPSHCCLIRKAVITPTTIRYTTPTVEMSNRVMRRYKHYEDRFLKVQFTEEMEKGRIAVNKDQNDEIYKRVLRSMYKGVRIGDRLYEFLAFGNSQLRVNGAYFFCPTEHLSCDDIRRWMGQFSHIKVVAKYAARLGQCFSTTRELHAISAPATRQIPDIERNGHCFTDGIGKISSFLAQLISEDMILDVIAQPSAFQFRMGGCKGVLAIWPNDTKVMEVHIRESQKKFESDSKGLEIIRSAAMATATLNRQTITILECLGVPIASFTNLLDHQLRSYELAMEDNDVAIDMLTKFVDENSISDLLRAGFKTDDLQEPFVVNVLKLWRSWSLKLLKEKARIQVQKSAFVLGCVDETGTLRGHSSETEGSEDKDIDRLPQIFIQLSDATHYNKTQIISGVCIIGRNPSLHPGDIRVVEAVDCPALHHLRDVVVFPSTGDQPVPNMLSGGDLDGDDFFVIWEPTLIPKRWNYPPMNYSAPKPIELDRDVTVDDLRNFFVKYLKNDKLPLIATSHLAFSDELGPMSSKCLELAELHSKAVDYPKTGDPAVLRRDQQPRKWPHFMEKKNSYNSRKALGIIFDKVKGKQVKFDPIWDSPFDQRIITKFELDRDILKSARKIKTQYDTSVRRLLSQHALKTEFELWTGFAMSRPAVGSDYKVQEELRREYTNLKGAFRQLCIDTAGSKSAEKLEPFVAAMYKVTDEEMKIALYEHHRGVINDTGTLLQPRKLEPKSMPLISFPWIFHREMCRMANSSDLELRTLLAAGPRQGEMPGVGEHLEPTVKNDATPVKHEVPEVSDLAPEIHSRLPDGTVLHRGQPLAIFPLEDDAVSDVDDDSPNGISGSGQSSSAGIDSGMVSDEQPDISSENVMQVEVPSDDDDVVEDDTDSIYSDELGEDEEEAMDRLVNLMSQVDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6G7</accession>
    <name>S0E6G7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparaginase</fullName>
            <ecNumber evidence="2">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_06887</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430203.1">
        <property type="nucleotide sequence ID" value="XM_023577078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6G7"/>
    <dbReference type="STRING" id="1279085.S0E6G7"/>
    <dbReference type="GeneID" id="35400364"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06887"/>
    <dbReference type="HOGENOM" id="CLU_019134_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006530">
        <property type="term" value="P:L-asparagine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000001">
        <property type="entry name" value="L-asparaginase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00520">
        <property type="entry name" value="asnASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484900" description="asparaginase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="11">
        <location>
            <begin position="46"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="12">
        <location>
            <begin position="261"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT68123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="369" mass="39416" checksum="3414E5C419E848BF" modified="2013-09-18" version="1">MSPSLQSLLALTTLVGSALASPLPEIPQLLTRAVSDFECYNASLPNITIYATGGTIAGSAGSSDQTTGYKAGALGIKTLIDAVPQLCNVSNVRGVQIANVDSGDINSTILTTLAHRIQDDLDSDHMQGVVVTHGTDTLEESSFFLDLTVKSEKPVVLVGSMRPATALSADGPLNLLSAVRLASSKSAMGRGAMIVLNDKIASARYTIKTNANSLDTFKAEDQGYLGSFENVEPIFWYPATRPLGHHYFNISTSSTKTALPQVDVLYGHQETDPKLFQEAIENGAEGIVLAGLGAGGWPDKAVDEIKKVLNETEIPVVVSRRTAWGYVDERPFGIGAGYLNPSKSRIQLQLALEKKLSIEEIKDIFEYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6J0</accession>
    <name>S0E6J0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferulic acid decarboxylase 1</fullName>
            <ecNumber evidence="1">4.1.1.102</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenacrylate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FDC1</name>
        <name evidence="5" type="ORF">FFUJ_06913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-4-coumarate + H(+) = 4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33227"/>
            <dbReference type="ChEBI" id="CHEBI:1883"/>
            <dbReference type="ChEBI" id="CHEBI:12876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-cinnamate + H(+) = styrene + CO2</text>
            <dbReference type="Rhea" id="RHEA:46920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:27452"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29749"/>
            <dbReference type="ChEBI" id="CHEBI:42438"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>prenylated FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. May form higher order oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family. UbiD-like/FDC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.102" evidence="1"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6J0"/>
    <dbReference type="STRING" id="1279085.S0E6J0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06913"/>
    <dbReference type="HOGENOM" id="CLU_023348_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046281">
        <property type="term" value="P:cinnamic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033494">
        <property type="term" value="P:ferulate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01983">
        <property type="entry name" value="UbiD_FDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032903">
        <property type="entry name" value="FDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="2">
        <location>
            <begin position="120"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="4">
        <location>
            <begin position="302"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="147"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="169"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT68148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="481" mass="53496" checksum="DAA91A14C3E148D6" modified="2013-09-18" version="1">MDHSFRDFVEQLKADDDLVEINDEVDPYLEAAAITRLVCETDDKAPLFNNLKGQNDKGLWRILGAPGSLRRSKKDRYGRIARHLALPPTASMREIIDKMLLASELPPIAPRIVAEGPVKQNSLTDGGKFLQTYGMHVLRSPDGTWTNWSISRAMVYDRNHITGQIVQPQHIWQIHEMWKKEGKDVPWALCFGVPPAAIMASSMSIPEGVSEADYVGAVTGRPLELVKCDTNDLYVPANAEIVFEGTISITELVDEGPYGEMHGYVFPGVKRKYPLFTVNKITYRDNAILPMSVTGRITDETHTLIGTLAAAEIRNACQKAGLPITDAFSTFESMVTWAALKVDTVKLSQMKWTPKDFQKKAGDVVFCTKAGLLIHRLILVGQDVDIYKGEDVIWAFSTRCRPNDDETFFDNVRGFPLIPYMGHGTGSPVQGGKVVSDALMPSEYSTGKGDWQAADFKNSYPNELQDRVLSKWASFGFSSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6M2</accession>
    <name>S0E6M2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit STN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of cdc thirteen homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_06300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432414.1">
        <property type="nucleotide sequence ID" value="XM_023579610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6M2"/>
    <dbReference type="GeneID" id="35399777"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06300"/>
    <dbReference type="HOGENOM" id="CLU_054798_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03524">
        <property type="entry name" value="RPA2_OBF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF33">
        <property type="entry name" value="CST COMPLEX SUBUNIT STN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="10">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="10">
        <location>
            <begin position="120"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT70335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="253" mass="28788" checksum="EA548B27F6F6D720" modified="2013-09-18" version="1">MSEPATPPIYPRYCFHLAPTVNQWCLFRVTDIHNLGENFYFYGNLPIKWVRVVGLVVAIDDFASRRVYTIDDSSGSCIECTISIPISGEDDSRATTGDAAPKKADIDPPQNPDPFPNIDVGCVVDVKGGLSTFRDERQLTIEKMTKVRGTAQEVTLWEKRVKFKSEVLDKPWVLRSSEIRRCRKEAERSEEEVEKKQKRIRAMVEPRASKQTSKSAGHAEQPIRQQKPHKEMRLDLRQILEQGGRGKYDALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E773</accession>
    <name>S0E773_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432833.1">
        <property type="nucleotide sequence ID" value="XM_023579291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E773"/>
    <dbReference type="GeneID" id="35399492"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06014"/>
    <dbReference type="HOGENOM" id="CLU_205482_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495613" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="54" mass="5554" checksum="6F394ECB74B536ED" modified="2013-09-18" version="1">MKTTVFVTLLSAAASLVSAGIVVTPVFFNQIVEKLSGDCPFGVVTPQGCAPQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7Y3</accession>
    <name>S0E7Y3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable clathrin assembly protein AP47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_08990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433060.1">
        <property type="nucleotide sequence ID" value="XM_023580248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7Y3"/>
    <dbReference type="STRING" id="1279085.S0E7Y3"/>
    <dbReference type="GeneID" id="35402464"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08990"/>
    <dbReference type="HOGENOM" id="CLU_026996_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT70981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="448" mass="50590" checksum="8CA41B90290DA2E4" modified="2013-09-18" version="1">MASALFFLDLKGKTLLARNYRGDIPMSAVEKFPVLLSEAEEDSSAVPPCFSHEGINYLYIRHNNLYLLALTKRNTNAAEILLFLHKIVEVFTEYFKALEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLEIQARPPIAVTNAVSWRSEGIRYRKNEVFLDVVESLNLLVSANGNVLRSEILGAIKMKCYLSGMPELRLGLNDKVMFETTGRATRGKAIEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECVVESHSGSRIEYMLKARAQFKRRSTANNVEIVVPVPDDADSPRFRTNIGSVHYAPEQSAIVWKIKQFGGGKEFLMRAELGLPSVRGDDEQGGGMMGGFGGSMGGVGGVGKGAKRPIQVKFEIPYFTTSGIQVRYLKITEPKLQYPSLPWVRYITQSGDIAVRLPDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8W6</accession>
    <name>S0E8W6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to ornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433403.1">
        <property type="nucleotide sequence ID" value="XM_023580663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8W6"/>
    <dbReference type="STRING" id="1279085.S0E8W6"/>
    <dbReference type="GeneID" id="35402091"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08615"/>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="459" mass="50219" checksum="AB3F77232BF78A53" modified="2013-09-18" version="1">MAHPFVSNSNILHRSFARQPDRVVSASGVSLFLESGREILDASAGTAVSCLGFGCPEITEVVANQMNQLPYLYSGARFTCDVTEELASMLLQGQPGGLSEAIFVNSGSEATDAAIKLATQYWHERGMPQKHHVIARKQSYHGNTIGALCVSGHKSRKAMYRHWLSHNVNFVDPCFAYRLKRNESDQDYVKRLADQLEAEILHIGPENVSAFVAETVSGTTLGCLPAVPGYFKAVREICDRHDVLLILDEIMCGMGKTGTMHAWEQEAISGPDIQMIGKALGGGFVPLSGVLLRNKIFDALADGSQGLAHGHTFQAHPVACAAALEAQRIIRDEDILTNVREMGKVLERLLRTNLGHMEYVGDIHGRGLFWAVGFVQDRGTKTPFPADRRLCHQIVDKALDLGLNILGNLGETGDIHVDHVIMSPPYVVTESELGRMVGILRESIQTVMSEVIDIQGAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9W1</accession>
    <name>S0E9W1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433519.1">
        <property type="nucleotide sequence ID" value="XM_023580809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9W1"/>
    <dbReference type="GeneID" id="35401961"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08485"/>
    <dbReference type="HOGENOM" id="CLU_057889_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="307" mass="34465" checksum="FB3A18F08428788E" modified="2013-09-18" version="1">MLRLQPTTIKIATRDISDAERRSRYRKHLISRQKVDKRRNDLIQHDQEAVLEDALNSRIVTPTTDSSIGHDTPVSDGRNESDGEEELGTRVPQLDYGTASSEETTYRDVDHGINRLHRQPDQHRLPFRPRQSLDDHGDADTAPAHTQPHDNGRDGSVTDEDERDTIEQLLAATLDGSTYETEEVNDDLSQSLGEVVETPEDAGELSISPADEGFEPMTPQRHFPVYNDRLPVEGQPRTPRQLPEARHQSRFDGAYTAPVRGRRVRVEIDDAPVTVRRRRAGRNTSPVGLRTPGFQGLYGGSENADDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBC4</accession>
    <name>S0EBC4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable sulfonate biosynthesis enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433111.1">
        <property type="nucleotide sequence ID" value="XM_023580312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBC4"/>
    <dbReference type="STRING" id="1279085.S0EBC4"/>
    <dbReference type="GeneID" id="35402406"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08932"/>
    <dbReference type="HOGENOM" id="CLU_062679_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413:SF1">
        <property type="entry name" value="PROTEIN HEAT-STRESS-ASSOCIATED 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="(2r)-phospho-3-sulfolactate synthase ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="317" mass="35611" checksum="A7EB47C3D3735C65" modified="2013-09-18" version="1">MSHANSFRAARQVWRASAAIPKAAIRPFSVSPRLETPPILLEDKDKGFGFIRHNSRPPKPRSVGVTEIRGPYYSVMGKRYLQDVLETMGHHVDGLKFAGGSFSLFPEDKLKELINLAHEYNVYVSTGGWMEHVLLQSNPVWAVDQYLKKCKQLGFDVIEISSGFLSIPQDDWLRVVDKVHSVGLIAKPECGIQFGAGGDTEASELSSLGTSDPSKIIHMGKRFIDAGVERIMIESEGITENVKSWRTDVIQQILRELPQEKVMFEAADPKVFNWYVREFGTDVNLFVDHSQIVQLSCLREGIWGQSDTFGSVVNYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBD9</accession>
    <name>S0EBD9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434334.1">
        <property type="nucleotide sequence ID" value="XM_023581670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBD9"/>
    <dbReference type="STRING" id="1279085.S0EBD9"/>
    <dbReference type="GeneID" id="35407189"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13735"/>
    <dbReference type="HOGENOM" id="CLU_077182_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34947" checksum="E4516F152309A8D9" modified="2013-09-18" version="1">MEARVPDDDLLFMSEEDFVVDFASHDLDNLPWNAPYNTNDAAFADVHQGTAFADAIDSVNTNSFGIYSNHTNPILYNTQELPALDTTYLDILPTNWDFMMMPTDPITTTIAGSITTTEQSDYSTTYTNSSSPTTQSSPTGLSQSQISDPLSAKNAENASSTSTRRRRTKMKPGTRPCDLKRQKRKEDKPEKCHICGKGHQWRRDLERHYWSNHPDEAVKMGLIRSESKLTVTQAHQSPSNDPGTSALVSTTCATMSSTSEDTPSIMSLDDEPLYRAPEGYYVGDECPNEEEQFTFTCPYIHCDGWIFASAEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBY0</accession>
    <name>S0EBY0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434203.1">
        <property type="nucleotide sequence ID" value="XM_023581515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBY0"/>
    <dbReference type="GeneID" id="35407329"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13875"/>
    <dbReference type="HOGENOM" id="CLU_542954_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="495" mass="55031" checksum="1947D0663BD51556" modified="2013-09-18" version="1">MLSAILLPRHWRLNTNDSDGSTCSGSHKRFTKRLLHFHRHKRNEPDVKDIDAKQPCAATSLIGNDDDRSIHHEARGRTCNSLVLLCNSSYPKANILSRARLHIQQNVLSLHRGYLGTLGLSLRVPFLIDPVPKLRIGTFSSDHRGATKGGPSQKRPPGSPGKSPADSTCKKQCRGSKNSDKTQNDRGSDDKEGKDKHRKRRKRRKEKDGPRFPWPEDSADRKRFLCPFYKAQPDRYCPCKGLRITSISYVTQHIGRCHVLNHVTLGAQGTGQSTNDNPTVPRTTTDPDEIVIYCPICRIEFYGPGADNRWDSHKNTGCVAQSIAQTGVLLPGEFQKLKLAVAAVSGDHEKWKKIWTACFPRESTPSQYNGAEITDTVASIGDGSQPQMLYQGSANEIRHPNHDPLQVLAPQTPDYTDTQDSSVLFNFFTDPWDMPHNIGNLGYATSDIPNPAPTGLGMTRTGWHDPGLMQPVTTAAQNHTFASDDWGTNNYNGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC14</accession>
    <name>S0EC14_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to URB1 Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434502.1">
        <property type="nucleotide sequence ID" value="XM_023581882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC14"/>
    <dbReference type="STRING" id="1279085.S0EC14"/>
    <dbReference type="GeneID" id="35405750"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12294"/>
    <dbReference type="HOGENOM" id="CLU_009575_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="97"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="629"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="887"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1130" mass="127134" checksum="7712C2E394426C9C" modified="2013-09-18" version="1">MGKRDFNSGDGADAFRKRQKVVHETPTSEEVTSSDQLRNLLSFDQDLRNARHGLQSFKNLLDQIVHEEGDRRANLDILHQYLEAVKPRDASEDAVFLNDIMEMWSFAVQVNNDGVISSVAVVLALLLQILSGSLQLVKHGLGICQTLLQEQQLKSLAKNLSAEKSKGFIISPTLRLLREATCLDGGAYAKRIFRARNFTLTSFGRNLEIGHIGDTQEDVRKASVRTNAVRFFLSLLKFLGSDGRKELVSQKELLSHVTYMIKSDPAYLVVDILDSLKLYVLKDDKIPREVKFRCFNTKSLVRFLALYTYTSDGEDVDEKSTVSHKAHQLLIYICTTPTAGILYPSTGLYPKESEDDPAPSGRAKAGTQGALFAERYKQDIPVYNFVLAEFAQKLRPWSSLKHSELLVAIFTSAPELTAKYFLSNRSFTFEPKLSMTWIGYAAFLFNTMQLPLPPRFGDRSRSAKAPPPTSILLDNIIPLPINQKVLIRCLSSKSNLTSFFATRILIVAIEKLAEAIKMHEEVSKGSDPVWAEASRRLIDAFCQRIPDMKEIVRSYKGTPAENILHKTMASRLLRLYYEVIPQVALAANFDVSPFFTEVLKSLNKKSERHEDESLRVMELENLVSIASYSPGMRWFSRIDNIIDGAGSSPYTALLRLLCDKKRDLSFQQLKKVLGEVAVENQMVTKASLMSSLFEALQTTLADVKAKPMEKVWSYVDNCVNRCASSPIKYLDLIETYAQEDGVSSGSETALVDVTLVEQLSFAMGSASSDEEAALGQFLSFYFSISYKFKPGKQLTKALYKRILEQFSSSKVKMKKIKEERSDDADADEDMPDADTVDANGSKDGSTIDSSRLEAMLLVPLPEDEDTTALTKWAGKNAEDLVEDGWAAALIRLLSSPHTNIRKESLTSILKMAAKLKDSSYEEKEQVWLLLCEIAESSRDEVEKGPVPSAFTAFAIHALDVLKNPLHPLYPKINSFLTRSPVWSADKLPLAHDILHGEPSEDDKYYTEITWLLTYLLDSLRTPSDLGIFHRKRWFEKILALDANPYLRVNLRTRLLRLLYRTTCIEGGSTTLTTRFGILSWLDSQRAAFEGCEEADVMVALMKRVWETCDQEKVKVWSKGGVERLLARHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECV2</accession>
    <name>S0ECV2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434849.1">
        <property type="nucleotide sequence ID" value="XM_023582296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECV2"/>
    <dbReference type="STRING" id="1279085.S0ECV2"/>
    <dbReference type="GeneID" id="35406119"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12663"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_7_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="41"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT72771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="359" mass="40420" checksum="76E8BB7074F34EB1" modified="2013-09-18" version="1">MAANGDEVTYDPAFLNESRQNEVYATHIAFFIVMMIIVPCRFFSSRLTKKTLSWDDWLAYFAAFNTVGVFITSMLWLRFGLGRHLAWVMQDDLKNIENFFKAIVANEIMYTTALACARLSLVAFFYHIFGVSSMRYFLHGFVAFIVAWAISTYVPSIRTCWPISSFWDGTNQNCIDLSKFYVGVAIGGIITDIGLMIVPLPYIWALKVPLYHKILIAIMLVFGSFACFVTIIRLTKVITVDLTDPTWGTVDLMIWTGMEVYSAVICCCLPTMRPLIKFVWKKLGLKQLSSSGNTDPSKPTSNGTAMWGSKSRQNSRHLGDGILASNADEVELTKHAYYELHSDNAHGRSQDSIAVHQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECZ5</accession>
    <name>S0ECZ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to DUF1479 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433776.1">
        <property type="nucleotide sequence ID" value="XM_023581121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECZ5"/>
    <dbReference type="STRING" id="1279085.S0ECZ5"/>
    <dbReference type="GeneID" id="35401681"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08205"/>
    <dbReference type="HOGENOM" id="CLU_011148_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="477" mass="53196" checksum="E1F296B72472C581" modified="2013-09-18" version="1">MLRASLAKPSPPVLRRCMTSLASKKEGDISDAFTSMSGVKREPLADRYRQLKLTLLQGREDKIVQSWNKLLRELRRENEIVAKKGPGVVPQIEFKDLERSSDALREEVKKRGVVVVRGVVPEGEARAYKAEVEEYVARNPSTRAFPPHDPQVYELYWSPPQLKARSHPNFLAVQHNLMSLWHTTTPTSISLSQPFSYADRLRIRQPGDASFALGPHIDGGSVERWEPEGYGAGHVFDSILQGNWESYDPWDASGRVDAVNNRYNGLGACSMFRMWQGWMSMSHTKPGEGTLLVNPLVKLSMAYVLLRPFFQARREGLGQGFLDEGNWELMRDVDSELQGATPGTGQELTGELHPHLELEKTMVHVPEIRPGDFVAWHCDTIHSVDKVHAGTADSSVMYIPICPITAQNAEYMVRQREAFLRGTPGPDFPGGAGESGHVGRGTEEMLDGAARRAMGLSALRTEGEDEVVREANRILGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDG9</accession>
    <name>S0EDG9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434997.1">
        <property type="nucleotide sequence ID" value="XM_023582467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDG9"/>
    <dbReference type="GeneID" id="35406272"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12816"/>
    <dbReference type="HOGENOM" id="CLU_024516_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="298" mass="33105" checksum="2801A1C95BAFA5A8" modified="2013-09-18" version="1">MTAVFYFFTKVTNRRYHGINDPATGEKLTEKARKFEYRKVLELPWTFWVVMGFSLFETSAAIVFLQNATELAEQRFGTDSIAAGWYSSVLQYSGFFVVPLLGVFLDLYGSRISVLVFCGIGMFTSMLLVCFSGAVKGTAASFGDFAFAYCFGSTTIIDSTRTSMWDNTVFGSAYAIKITMNNAMNIIVRIITGKIQDADNNSYDKVTIIYVVLAGLSVVVSILLAIGAWKSVDLGHLQWSRKKRIAQGSLLNERKEIFTKKNGEKNRRVSLACFATLILLVIGSWCGHFWGVATGNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDL7</accession>
    <name>S0EDL7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432567.1">
        <property type="nucleotide sequence ID" value="XM_023579794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDL7"/>
    <dbReference type="STRING" id="1279085.S0EDL7"/>
    <dbReference type="GeneID" id="35399943"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06466"/>
    <dbReference type="HOGENOM" id="CLU_576242_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT70488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="474" mass="53926" checksum="BAFFCB563948B9C2" modified="2013-09-18" version="1">MGGEDQPPFQDEIGVPKLAFKGENVEDGLGYLNTLCSLKPGPSSANVEELGEDSSPNSESDESSSITDTCVDDQKSLMVEKIVFIVTQWLRPKLDAWRRNAADNSKTAPKTSEALSGSYLHTETSNTVNCRNEKRKATERDDCETDDEGEGRNRGDQGSSGMSIRGHEKPKYACPYFKYHPAKYRDWRTCPGPGWNDVHRVKEHLYRRHKQPQYRCARCWQPFTDQQGLTHHQRADEPCPLREMGYVEGFDATQERSLKSRKRVNQKLSETEKWRRVFKILFPHVLDDDIPSPFYDYSQTPQKDDACRHSESGSLAQCEQYMLREVPQRLRQALGRELDRDLTIVEDNLRRRAGDCVRTLIEEVFQELRQIRRLSSPDPRLEANNDISALAEGPRLLISELPSGEDANPHFEGQGEAWPTNFDLDFFDPSSIFEELQLSFDNGGLIEDLLRPGEDGANESMKQSDSGYVSNSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDW0</accession>
    <name>S0EDW0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435184.1">
        <property type="nucleotide sequence ID" value="XM_023581786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDW0"/>
    <dbReference type="SMR" id="S0EDW0"/>
    <dbReference type="STRING" id="1279085.S0EDW0"/>
    <dbReference type="GeneID" id="35405663"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12207"/>
    <dbReference type="HOGENOM" id="CLU_061288_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000058">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000257">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000027">
        <property type="entry name" value="Calmodulin (CaM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="149" mass="16997" checksum="391C14BA2C533A89" modified="2013-09-18" version="1">MADSLTEEQVSEFKEAFSLFDKDGDGQITTKELGTVMRSLGQNPSESELQDMINEVDADNNGTIDFPEFLTMMARKMKDTDSEEEIREAFKVFDRDNNGFISAAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDYNEFVQLMMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE65</accession>
    <name>S0EE65_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to phosphoenolpyruvate phosphomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432777.1">
        <property type="nucleotide sequence ID" value="XM_023580044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EE65"/>
    <dbReference type="STRING" id="1279085.S0EE65"/>
    <dbReference type="GeneID" id="35400167"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06690"/>
    <dbReference type="HOGENOM" id="CLU_027389_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF7">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE PHOSPHOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="404" mass="43934" checksum="2907DD1833A0F569" modified="2013-09-18" version="1">MGSLHTELSPSPAFSSVRSALAQNNNRIILCESHDGTSTEIIRATVGKNGQKFDGIWYSGLCQTTYLGIPDSETLSPLQRASLLALDGELKRKTSNRSLCAAFDADSGGDIADIPALVALMNLVGVGMVVIEDKAVSAPGQKVNSLAASSASQALANPHEFAEVIRAFREVNAKAKGGPMITARIESFCCRVSKADAEEESRSYEAAHQDALNRAKVYHEAGIDAIMIHSKSKSPHEVTRFLREYREFDSQTPLVVVPTTYSEIPKDALYEAGANVIIYANHLMRAKISAVGSISDKILAKNLDLFYNDAEIRAMIQARNYGCLLRKLRNRSAWGEESNEARMYRIVAEATASENIQATVIDLLEGKLAGCEADTRIVSVKELLKINAKQVVPVAELVTQVDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEB0</accession>
    <name>S0EEB0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_13814</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434260.1">
        <property type="nucleotide sequence ID" value="XM_023581583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEB0"/>
    <dbReference type="STRING" id="1279085.S0EEB0"/>
    <dbReference type="GeneID" id="35407268"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13814"/>
    <dbReference type="HOGENOM" id="CLU_063084_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485537" description="CFEM domain-containing protein" evidence="11">
        <location>
            <begin position="17"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="12">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT72182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="195" mass="19216" checksum="71713B502A98C9A3" modified="2013-09-18" version="1">MKYSFAIAALATAVSAQSLSDVPKCAIPCLDDAITSKTKCETTDLACVCKSFDDVRSAATGCVITKCGSDVAINEVLPATEKLCSGGSGSGSGSAEESSKADTTKVETSTKVVVTTSAVETTAVETTAVETTSVPPVVESKTTAVPPVIETPTTKSEAAGGATSTPAPSGVGENSAAGLKGLGAMAMAALMALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEI1</accession>
    <name>S0EEI1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to heterokaryon incompatibility protein het-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432902.1">
        <property type="nucleotide sequence ID" value="XM_023580060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEI1"/>
    <dbReference type="STRING" id="1279085.S0EEI1"/>
    <dbReference type="GeneID" id="35402633"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09159"/>
    <dbReference type="HOGENOM" id="CLU_004184_7_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="111"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="663" mass="75607" checksum="30AC25F1C11C55C3" modified="2013-09-18" version="1">MSRGTSSSVSDLGLGPGYTPTPQNNCTNRHHYILPKEAKIILALAPTNHSSPLFRFWLRPDGPAFSQIIMNIAYPPLSRDDIRILDVSINGEDSEPICNFRVVPLENPPDYTAVSYCWDNSTDIARIKFQNGDSLPLSQTLLDLFNSLKERTSKFTVWIDAICINQEDTTEKEFQVPLMGKIYSRSKEVLVWLGNSDDITKNAFRFMKQEENDVETRPEPLVRSSSFYDKFRSLYRKVSQPSRQENDEYGLESMLLLLQRPWFQRVWVIQEVVAGGNIQVICGEDCVDLSHFSDGVSAIWNSFTGLGRYEDDHPAILGFWCVTRMLGIREEYQNKVNRGESGVCYETLLQAAYHCQATRTCDKVFAFHGIADSRPVPKANYRITEEQVFVETAEALLCNGDSLDLLALSWMGYMRQHSSIPTWAPDLRCHAYDEPLVLCDSAGWDAGGRLNTPPKIDAESPRRLRLQVKQLDTIDVICPPFASWVVEKQRAAVKSILALRSRLAGNLSREAWMDRLAESLIMGLDIDDSPLRVGMPGWDEHRRQFNEWLQWVQSNSRQKNLHKIESNMHHRIIRTRIDTMKTFASSRGFFGIGPEPTMEGDVVYAVPGCRVPLVLRPDPLTADEEMRSLPVQTWTLVSWCYVDGSMFGEAMDQERPFEELLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEM1</accession>
    <name>S0EEM1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435494.1">
        <property type="nucleotide sequence ID" value="XM_023568265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEM1"/>
    <dbReference type="GeneID" id="35403261"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09794"/>
    <dbReference type="HOGENOM" id="CLU_010409_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1128" mass="121768" checksum="F37B8CF7184D1F35" modified="2013-09-18" version="1">MSSRQPNMTNMAQRNIQQGAARQQNQPFMEQNGNAFQFNNLQQQQFAQFMQSQNGLGQMQNQNQIIGGFTSPSDDTNNNTNFGSPMVVGTHQFNPYWAQSSSSTPNMASGNPSFESFTQSQTPFMSNSQNQFHGSMQNSFMGNIQMPFMSDLSMQPPFFPTPPMGNAQTPFMSNTQDSAMSDSQGQGFVQHMSGLRATAPSFIPTQNSPVPQKSAVSMANMTPQMHAQMQQMEMRINQQQAIINSMMMRSSGSSAQSNSQHGPAFQMQQTPTTQVPSPRASTPATPPAQNPTAQFLSVQSPIAQAPTNEPVAVHSPTAASLTTESSGSQGGNTAQTVPALSANPDSMTEQGSRVNQRDSSLTQISSVMNTDLATNPRTRLLLQDARPHATPPPQHKLQDFLGDDAHKVVTQELSGDQSSTSQTSPKQDSSAEEPSTPASSNGFSSFEDWSKERVYAPGIFAPRRSDGPEKITQKEKKLREAEDKGQKVFPSKRRVVRIDPEDPRLVRDANGLPITPQGDSYNIYYLPGPKVLDTAEINRMLAEIRAEKKTAMDEAAKTGEPIQYSKSTKRNRKSKTRVLKTPSENIANKRRRKTTNTTTTTTSTPKVVGDAQLATTLAVQPSLNNGPIAQASDDPFTIKSNTAISAQFTGGDVFNQQASMSFFPPQVILGSDLIQSFTAGNTQPPTTGSDLTLQVARENSFTSQTTFEQPTANLTGNDCTSQPCNPWEDNALQPAEDFTNTNDPMFVDNRNTLDEDLPLDAEPIAQLSLTQCDSSHPPSTPVSESGAAMTPDHCLFPLLTWLAANSENDSTAHTVDPSLSVPCPDIFKTCQPDVTLGHKDTLSEPFDEITMFPQDDEQGTQLRKVSNELDRPLPGQPDTVVYVADIPNPSNRDLNAEHAAVIDRFRAGDESIDVDAVNRQTAGVTEGMSPADIPAFGDDVLLHVFASLEDIPENNLQDPNATTGNDNTMFPVTGCSDFNSSNATGHASNWPPAAPNVSLTDMPCSPVVASQETQDAPFQLPQSPEFHPQDPNNSLFGDLDQDNNTTNAAPEGVFLNPAVLNQTTATTLSTSATATAAAANTTKTGNNKRKAGEDASAAPNKKARTKKAPVPQLALPQCEVRFGPGAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEP7</accession>
    <name>S0EEP7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432942.1">
        <property type="nucleotide sequence ID" value="XM_023580109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEP7"/>
    <dbReference type="STRING" id="1279085.S0EEP7"/>
    <dbReference type="GeneID" id="35402589"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09115"/>
    <dbReference type="HOGENOM" id="CLU_060131_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="215" mass="24504" checksum="1F7630251F0099CD" modified="2013-09-18" version="1">MERTIDQELRMRQATVDDLDGITKLAIEAFPDDPERDYRFPYRHEYPEDQWKWTRVEYEGFLKQPESYDILVIEAGQKIVALGIWDVSGLTGVKPVKPGVLGDNQRRDANLPHLRYFASRVEEVYDMHLSQFGSKQLHLVNLATHRDYRRRGCGAALCKYGMEKAEREGFVATVFGSPMGIKLYTSVGFKVIGAEPMIMPGDEEGLTTTALVWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EG51</accession>
    <name>S0EG51_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable protein phosphotase 2A A chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_08560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433452.1">
        <property type="nucleotide sequence ID" value="XM_023580724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EG51"/>
    <dbReference type="STRING" id="1279085.S0EG51"/>
    <dbReference type="GeneID" id="35402036"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08560"/>
    <dbReference type="HOGENOM" id="CLU_015533_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030952">
        <property type="term" value="P:establishment or maintenance of cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990813">
        <property type="term" value="P:meiotic centromeric cohesion protection in anaphase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="13"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="206"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="247"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="280"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="286"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="325"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="364"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="520"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT71373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="623" mass="69337" checksum="909FEF01C6EBF7BD" modified="2013-09-18" version="1">MADAPNSGDELYPIAVLIDELKHDDVLLRLNAIHRLSTIALALGAERTREELIPFLDESVEDEDEVLVALSEELGGFVEYVGGPQWGHVLLSPLENLASIEEPVVRDKAVESLNKICTELSSQQVEEYFIPLTIRLAKADWFTSKVSGCGLFTSPYNKVSPPVQEQLRQQFGLLVHDETPMVRRQAATNLAKFVKEMPATIVVDEMIPLFQHLAQDDQDSVRLLTVEVLISIAEAVPKEQQASHGVLLTALRNLIEDKSWRVRYMIADRFEKIAKAVDEEVVSRDLVPAFVKLLKDNEAEVRTAIAGQIPGFCALVDRNVLLNDIMGSIEDLVSDTSQHVRAALGTQISGLAPILGKQETIDHLLPMFLQMLKDEFPEVRLHIISKLELVNQVIGIDLLSQSLLPAIVQLAEDKQWRVRLAIIEYIPLLASQLGVQFFDEKLSNLCMGWLGDTVFSIREAATHNLKKLTEVFGVEWASEAIIPKVMAMGNHPNYLYRMTTCFAISTLASVVSMDVIAKSILPMLDKLVTDDIPNIRFNVAKTYRVLINVLRRLPDEGTLYDLEKQGSEITPSPRGSELIQQRVVPNLEKLQKDDDVDVRYFATTAAAEISGPIAGGEPMNTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGL9</accession>
    <name>S0EGL9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436012.1">
        <property type="nucleotide sequence ID" value="XM_023568888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGL9"/>
    <dbReference type="GeneID" id="35402703"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09234"/>
    <dbReference type="HOGENOM" id="CLU_084522_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF2">
        <property type="entry name" value="CUPIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19688" checksum="7A68F408F2DA8BF7" modified="2013-09-18" version="1">MSSSVECYLVPRTEDAPNSRLPILVYRDVLPQPRIEETATRFLTTHRWEKRGTWGHIAIRHFHPNSHECYGIFRGSSTLLLGKIQKGMGVEVPVRAGDVVVLPAGTAHSSLESSSDYRYIGVYPKGCPKWRNEMGKKSSSVFLNAIDEVDMPEDDPVYGPDGPLPILWSQAPRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHI3</accession>
    <name>S0EHI3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10008</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435385.1">
        <property type="nucleotide sequence ID" value="XM_023568026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHI3"/>
    <dbReference type="STRING" id="1279085.S0EHI3"/>
    <dbReference type="GeneID" id="35403475"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10008"/>
    <dbReference type="HOGENOM" id="CLU_026278_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495962" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT73307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="360" mass="39094" checksum="3D0B42DF8B65E43C" modified="2013-09-18" version="1">MQFSLLFLSLVGAGNAILLPKPSGPYGTALRIEGMTDKSRIDPYDPKKGHRQVLASIFWPVDSSSCSNKVVPYMPPATAKAYGQQVAQLGLSNDTFSALEFQVCKTPISQKGCETEKKSFPVAVFSPGAGNSRLIYSLMARSLASYGNVVVLIDHPYDPPVVEFPDGKIIKGGNIPDDPKSNQQLGSVKAKDISFTISELLRPSFQKKVFKGLPGSIDNKKIVALGHSLGGASAAIAMLSDNRIRGGMDLDGQIFEPALSKGLDKPFFLIGRPNHSKEDTTWKTFYAKLRGPKKEIAVKDTVHGSFTDYPQVLKALGLPEALMKAIEQQVGTAEPSYLQNFLSKTVVDYMKLSFAYKGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHS8</accession>
    <name>S0EHS8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable phenylacetyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436422.1">
        <property type="nucleotide sequence ID" value="XM_023569170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHS8"/>
    <dbReference type="STRING" id="1279085.S0EHS8"/>
    <dbReference type="GeneID" id="35403857"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10392"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="467"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="568" mass="63127" checksum="423B0E0E4F6F0026" modified="2013-09-18" version="1">MVFYPPSWVPDLPIDPPDSVSVAEFMSSEEYGRYPIATARHPYTCGLTGKTRTVEEVILREDFLARGIGKALQLDSQAGSEWDRVCVIFSLNTIDYIPLTHSIHRLNGIASLSSAALSTSELEHQLRASRAKAIFTCAPLLDTALRATDVVGISRKNVFLLPVPNATSRHGFKTIDDLIKEGERLPELPPLQWKKGQGARQTAYLLYSSGTSGLPKPVMLSHYNIISGIIQTCTFDSVSRKTDGVETQVMLGVLPFSHVFGLMLIAHLGTYRGDEIIVMPRFEFEPFLSAVSRFQIHQLPIVPPIVIQMLDRRELCRKHDLSSVRFVYTGAAPLGKETVDDLLSLYPNWRLGQGYGMTETATVFIQSSEHDTEVGTTGSLLPAAKAKIVDPDGKEITEYEKPGELLIQSPTVSLGYFNNPKATAETFFVEANGRWIRTGDEVLVRMSESGNEHFVVVDRGHQVAPAELESHLLTHPAVSDCAVIQIPDARAGEAPKAFVVKAKHTSQSEEELVRDIQRYVEEHKARYKWLKGGVEFIEAIPKSPTGKILRRKLRDREREARKSEGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHT9</accession>
    <name>S0EHT9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_10263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436298.1">
        <property type="nucleotide sequence ID" value="XM_023569026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHT9"/>
    <dbReference type="STRING" id="1279085.S0EHT9"/>
    <dbReference type="GeneID" id="35403728"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10263"/>
    <dbReference type="HOGENOM" id="CLU_003864_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT74220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="789" mass="88735" checksum="99511A4FEEC88B00" modified="2013-09-18" version="1">MTFACHECWAVFVRSEHLQRHMEGHMGMRPFSCGECTASFSRKDILVRHMQIHESPETPPAKQHRTPYVAQACLKCAKSKQRCDGQLPCGRCTSKRLQCSYPPSKSRRATQNTPGSVASQNQGLQNEANHTGFCDQPGLNQQLQSSTESDTTSLSYWPPSNNESMTGLSSQPSLAPDQNIGSVFGVYGDFEWSGPSDAGAFWGLETYLSLGAMPTLSSPSALESSQSLADATPNLQPPASSGPEVGRPETDKLAPRVTQTLESPHSSNGRLSDRSLSATNDCIDPDSDAWRAEDYCHVPRLSEDVYQEMIKHFARYNRDDEYWSIFTSSDFPPITHINTFIQVYFEEFHSLLPFLHKASFAPTKDQWILSLGVAAIGSIFSRVANSSVASFNLVELLRRAIHVQSERVRSSQPDISFVQAVLLNQLGMMFGPETTRIEAVPVTRALLETLCRKTACYTNFDAFCQPLDSENSGEDNWADWIKKESLRRLFYSVWILDCEYNCFWSGLGIVTIDCLQLPAPLHPKLWEAPSQETWKKHKTLHEPVPFGTVLSEFYRTRKIDSSDPFNTLLLIVGVKYHAERLNRAPIYLGILQDHAKTLPPSRLSGAVESLSHLLSMLIYSPVQELYAFSGWRVDTAQRAIVHAKLRTWIQSTSEARTALMHACNAWSMIRRSKTGAQHETMGFLVATLLIWAWIKLGNRPEVDDMDLLLTVRLDEGKDHIKEWINNNEERRLYLGGVGCLWDMGADRRLLQESTNTLDSFDWPAAHTIASILREHYRSFDQVATVSPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHY8</accession>
    <name>S0EHY8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436482.1">
        <property type="nucleotide sequence ID" value="XM_023569239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHY8"/>
    <dbReference type="STRING" id="1279085.S0EHY8"/>
    <dbReference type="GeneID" id="35403918"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10453"/>
    <dbReference type="HOGENOM" id="CLU_010194_17_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27691" checksum="16E633943C3825D1" modified="2013-09-18" version="1">MAPSGLAIIIGAGPTSGRGIARVLARNDGGNLAVALLARNPNNLNSLRDSLRKETNGVLHSFPTDTQPENLRKAFKDIANHPDFKDLKLKLAIYHVKHASKKPFLEETPEGFNESMQVYTTGAVVFAQEALKLMYEQNGGQTLLADTNGAKKGTIIFTGTLGAMRTNTGYAAYGATRASARMVAQAIAKEHSRFGVQCVHAIANGRITDEDTEETRTGKHMRAEDVGQTYLWLSQQPSSLWVHELDLRPAQESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI16</accession>
    <name>S0EI16_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to ROD1-O-dinitrobenzene,calcium and zinc resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_10486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436512.1">
        <property type="nucleotide sequence ID" value="XM_023569275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI16"/>
    <dbReference type="STRING" id="1279085.S0EI16"/>
    <dbReference type="GeneID" id="35403950"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10486"/>
    <dbReference type="HOGENOM" id="CLU_018982_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="186"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT74434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="503" mass="56444" checksum="70A26218CDC4909D" modified="2013-09-18" version="1">MQASSTNQHNNQPLAAAFSGVASTPYSLFEIRLEREFVVFWGSRYESTDQLLKGVVVLCLQSPLKLDEVRLRLDGTVRHAWLNDPGVAHNTSIMKHKWPSLLETGGRSVTLPAGNYEWPFELMMAGDTSESLEGIRDASITYGLRATISRGKLARHISCTKKLRIIRTFAPTALEFMHNMSVEQTWINKVDYSVSIPTKAAVFGGSIVLETRFTPLVKRLEIEKIVVTLVEFQEFSMHSRHYIYTREHKSKREISQWDFEMSREQYWQDTIEETGQEGWVMKKTLQLPKRLSECIQDIDTQGIRVYHKLKIHIPIRNQDGHVSHVSQPFSRYRAQGLTSQLDLGIPVNIFISPSITLDDQGNLIDQAPTTQGPPNELIGPPVYGEHILDQLYDSLEDWQIPGQGTHQGEGEGSGTSTPHHADSNESQIYESSNTLESSQSSQSHNPSRSSSETVSTDPEEFAELSKVPTYRTALRTPLQPHAQQGGALPPDYRTASATAATDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIC3</accession>
    <name>S0EIC3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein HSM3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435660.1">
        <property type="nucleotide sequence ID" value="XM_023568465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIC3"/>
    <dbReference type="STRING" id="1279085.S0EIC3"/>
    <dbReference type="GeneID" id="35403081"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09613"/>
    <dbReference type="HOGENOM" id="CLU_064433_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041335">
        <property type="entry name" value="HSM3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18795">
        <property type="entry name" value="HSM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein HSM3 N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="369" mass="40312" checksum="299570B845115805" modified="2013-09-18" version="1">MSERVVPQNSDSAPVTGLAELLAHLTELHEPGNGSAPLNNKLFDDVELQLTPSNIPIIQPTLLPPLMSLLKTTTQDPTSLSVVFSLTTKLLSPFSFTQCLSLGGAESLVSALQSPLPGANLLALNIIQKAASSPAEVDSLASLPEVVEELLRIWLSSPDADVGGRSTRVLGSLLETDCDIIPETTMSNGVNGTSPPETQLIKRRIPGHASLWRLVIWDRHYLELIASLCRPAIINRQATFAQDRLLRLIPRLTALHPRAMAISPFPDLFPLPEYADEFIGHGLLQWAALNMVDTSDVLMHQTLIVFYESFVSIMRIAGDSADKDAIVRNVVKAATSQDQELKQVLRTLPDRTIQEEAEPLASYISRILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIU5</accession>
    <name>S0EIU5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434381.1">
        <property type="nucleotide sequence ID" value="XM_023581727.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EIU5"/>
    <dbReference type="GeneID" id="35405611"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12155"/>
    <dbReference type="HOGENOM" id="CLU_002714_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1459" mass="158533" checksum="08CC7C5E66EAA953" modified="2013-09-18" version="1">MGTEPGVISNAPKPLNRSGRREEIPRPLPKPSSISRPSARPPQPSTTRRPSIPQPVPRPSLNQQAQSWGSSSTSASTRSTVNHRGGSGSSSSAQSMDNPRSNPNVLRRKKSSLSGDVKTTRTGSSRTDSSSSSSQHKRQGSLDPAFGFHLDRELTSSPAEIQIAEVVEVKKPSKSPVIYPELDRYRNIRRPSDSSDHRIEVPFRLATHDLPPPTPASLLFSGTSGSPSTRFSESPGPGSYSRDTTPTSIASQSPGLVAPLRTQNKNRLQSPILNRPPVTRRAGGSFPNEVDAITVDPHGLAAVRESLTSSSSNSTVREATIKKKTKNLPPPPPSPPPRKSSQYFREETSLPKSVRKVSRPVLRSPSPERSAQSSASPRAVPPSRPSRDGTPDMQSQLFNPMPVIHSNLSTQSLPSTERRGSESANTTALSPPKPQYTHGGRTASTSQLPIRGELYAQPAAKATAEPKKGKGLEPPRMTRTPSPNVATPSISRFPFFSRKKHANGAQAEKNEKEKKTLRKGPVAGTGHEGYGRIGASKRRSGSISNMTRNSPGSQTTQEPRSSNDSFFADRVNPVVIAGGAVIENRNASSEISRSVSSQSLATQESRFGSTQSLAASQDQPRNTLWPSPMLRTPHPAFGARRPSESSDSEGPTMKSTLAFRRSVHRLRSSPDDPLKLPQPINTSGYASSPMTSFDTSVMSDESHFELQREISHEAKSSHPAPKKLVKRPRSPRKWNLFGRSTQTQQPKQSEKVSATVKPVEKKPLAFYAMMDSSEQEDSEPMDIQDVLRFAEVYGKSPSVGGTPELSQGTPEMRSSTNSPVRPAEPTQLPRRESVEMKTKPRLPVPQQTLMSKKPTLQPPSTSTTASRRSRLPQVGRIPKVVSNRTEHVSPMSFSRPFRASMQLAPENLEVYDPESIAKGPSPSRPSTPVPDLTTDGSTAGSTNNLSSRDSNPPALSRVEKEFLAFSPRKDSEGTIGTSSSSCSGILAFSGSTAVIPQPYDPPAEDEVWDEYDDLLGEDAGKALPSATSSRGTPFHLETYESKLASKEKPLESPTVVFDKKASRQSKATTISSTCSADMTERLRAAFQPHPSPSTPFSVSKFVSGYEDRNTNTEVPAAGEVSRRSSRSSRKTRRSDASSSSEDGSPLAQVNLRVGSMTVSKWLTFGHVLFSDVRHELVPVEGSLKRHSILVIDGLGNDDWSFYAAETYPAATFFNLSPRAPLPEELKSSSSSFPLSPPNHHQIQYVSHLDKFPFAPQSFTAVVYRFPVAAPEAYYRSILTEARRVLKPGGFIELSILDVDLNNMGNRGRRTVRRLKERINEKTPDTSLGSTADLIVRLLGKVGFTTIKAARVGVPVASSVTRSDSKADKGKAITEKKKDPPSLSEMMSDNSPLADEGITKMVSRVGRWWYTRCYENAAGNPSGKSLWSDKSLLSEAEELGTSLKLMVCCARAPLERITSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ72</accession>
    <name>S0EJ72_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to AM-toxin synthetase (AMT)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436753.1">
        <property type="nucleotide sequence ID" value="XM_023569554.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EJ72"/>
    <dbReference type="GeneID" id="35404200"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10736"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056896">
        <property type="entry name" value="SIDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24895">
        <property type="entry name" value="SIDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="759"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1549"/>
            <end position="1625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2067" mass="228038" checksum="7D658C4135BBDBB0" modified="2013-09-18" version="1">MGDVQSSAQPRAKGVRYEVPALRKQQDQDSYDLEILLLAWTLLLYRHSHGNHVEFSWGLSEIGSSTCRTFTLNTSKLEWDGGDSVASELKVFRNYLQQELQSEQPFETKEYKFFFNDEAATGEVVTNVTEDGELSVNWGNVQIEATVEDDVLWLRPTWREPLGAEFLANHFAQALVEVLNTTLTDSTATISSVLPLGELDKSVIWNWNKDLPPPVPMCIHTLIAEQVRWRPDAPAICSWDGDFTYADVDRLSTLLAQHLIDLGVKVGDIVPLCFEKSRWTTVAVMGIIKAGAAFSLHDPSQPMQRRQVMAQQVNATHILTSRDQAKYGPEIAPDAKHVIVDTATLDSLAKTIQDPLRKLPDVPPNSLLYIIFTSGSTGTPKGVMLSHETYTASALARSTGIGYSSTSRSLDFTSYAFDVSVDSILCTLIRGGCLCIPTDQDRVNDLSGAIRRLRVNMVNITPSVARILDPDIIPSLNSLGIGGESCSAGDIAIWGQHTRIVVGYGPAECTIGCTVNPSAAGKPYVSIGPGTGACIWLVDPDDHNKLVPVGAVGELLVEGPIVGQGYLGDAEKTNAAFIHDPDFLLAGAGGIPGRHGRLYKTGDLVRYDPDGEKGFVFVGRKDTQIKLRGQRVELGEIEHHIKNLLPAGAEVVAEIIAPRNQNKESMLVAFIADREAKDDGDARQIDFPPRLRDSLETLNERLSKVVPVYMVPATYITLSKIPYLVSGKTDRKSLRALGAEISANLQASAAANESSEIREPESEAELFLRDSWCRLLGLEATQVSTTHNFFTSGGDSVLAMKLVPVIRDWGYTLSVADIFNYPVLADMAKSMQKGDKSKGVDMQIPEFSLLKDNMDRDALRAEAAEQSGCDVSAIEDIYPCAPMQEIHMAFYTRSKENYVAQRIADIPASSSVDKLKSAWDVVYKESPILRTRIAEFKQHGFMQVVVNESLQWREVESSLEEFLEEDKKEPMSPGAPLSRFAIVTDKALDKRYFVWTAHHAIYDGWSTDLIVEHARAAYKGEEVSRPAQFKHFIRYLAEDSRESSKDYWKTQLAGATGPQFPTLPSRSYIPDPTSLTERFIKLDKAAKSDITIATVIRAAWALLASQYSMSDDVVFGETFMGRTIPLPGAELIEGPILATVPVRIRLDRTTTVQEFLRAVQEQSVARSAHEHLGIQHIRRLSEDAQIACEVTMGLVVQPQDPEPSETETDELPSFRGGDAALEALHFNSYPLMLAVSLQKTGFRLLASFDSELLSPVQVQRVLSQFEVAINQLRGDVSRSLSDITCLGEEELGEIWEANKQAPVSPKDISRFLSSGDKYPTVQYVPWIVQPGNEKLLMPLGSTGELLLETASVRDDADVVDAPEWLKEGALGYPGRQSKLFHTGDLVKYTDDLSLVFVGRRDDMASVDGRVVDLNATNLELKRLLPATAEAVSRLVVPKGSSSQTPVVVAFVKDTPARDAQLLKVGVDARDASLPLAEEVSVELAAAIIGLNKAMVETLPPYAIPSICIPLTSSVDINSIETIASETSLSLIVELRKSFVFLKKTIADTTVLTTKERVLRASWSKFLGIEEEKLSLDDNFFRLGGDSIVAMRMVSALRQDGYRLSVASIFQNMQLRGMAKSLVEISPEASESTKRYTPFSLLGIKDVDGFLAQAIQSQLADPTWKIQDVLPATGPQSGDVKQTVSAPRSSLQYNMLYLDQSIDTARLVDSFQYLVSQHAILRTVFVQHEGQSLQVVLSDVTVPVTEQSVEGSIDDAAKQIAESDANNSTDLAFGTSFIRLFVLRSETENAFMIRISHAQYDGVSLPELLRQLELRYRGLEIPASEPFETYIQHLSTAKSQNVDFWRKTLEGSSYTEIAPAAEPQQKTAFMTKDVDISGASPDTTHAMLLTAGWAKVLSQHLNVSDVTFGGIVSGRDVDVAGIDTIMGPCYQYQPVRVKFEQSWTASQLLDYVRSQSVEGSQHATLSFQEVLKECTDWPAETPFYGSFTNHLNKEFFDSIPFAGTKCRVDYSIPHPEPATPPRIVSFVENGRTQIGIEADEERRDFWEARVEELARVIEGFVKNPNVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJB6</accession>
    <name>S0EJB6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GLO1-Glyoxalase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437159.1">
        <property type="nucleotide sequence ID" value="XM_023570032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJB6"/>
    <dbReference type="STRING" id="1279085.S0EJB6"/>
    <dbReference type="GeneID" id="35404628"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11164"/>
    <dbReference type="HOGENOM" id="CLU_046006_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF19">
        <property type="entry name" value="LYASE (GLO1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="27"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="208" mass="23239" checksum="86F7A1F211AC4465" modified="2013-09-18" version="1">MPVGQFMANGLGTDQPLTPDDPTIGYTLFHVMLRIRDPVKSLHFYIDLMGMRTVFTMNTGPFTIYYLGYPQTEEHRADPAKFGRDTLSQLAYTPGLIELYHVHGSENEPEGYYSTGNEPPNLGLGHIGFSVPDVPRAVERLRNHGVVVIKDLGAATRQDVPLSQWEAEKKIGLGNLHPAYQLVFEQIAFVKDPDGYTVELVPQKLQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJZ0</accession>
    <name>S0EJZ0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to hydrolases or acyltransferases (Alpha/beta hydrolase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434786.1">
        <property type="nucleotide sequence ID" value="XM_023582225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJZ0"/>
    <dbReference type="STRING" id="1279085.S0EJZ0"/>
    <dbReference type="GeneID" id="35406057"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12601"/>
    <dbReference type="HOGENOM" id="CLU_034451_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485990" evidence="2">
        <location>
            <begin position="21"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="251"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="452" mass="50270" checksum="744A01333216336C" modified="2013-09-18" version="1">MLSFSCIITWGTLLAAVTNAHETEAYPPNVTISNTTTSMFQLSNDTEFSFILSEYLSLANEGGSATGEVLRAAAVIEPNNPESWYHEFKFLADKIREQAVAAEKKKDWVSARSAYFRSSSYYRGADFFLHGNQSDPRIDILWQKQNASFTKAVNLLPNPPTFVELKATKFTVPAYFYPGDAQLPAGKHLSYGKKIPTVIVGTGYDGSQEALYHSNCREIIQRGWNCITYEGPGQATVRRKQNLGFMPEWWEAVTPVVDYARNRHDVDPDRVALIGMSFGGLLAPLAATHEHRLAAVLAIDGMLNLQRSILEQFPPALTKLFLSGNSTAFDGEIYSLLKNPKLPTALSWPINQGMWAWNTKSPFKWLTMVGEFNLDKQSLAKIRCPVFVASGQDDMTAPEQPEEMARAFGKQAHYFLFKTKLGSGVHCAIGAENQLAQETLGWLEGVFDKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK18</accession>
    <name>S0EK18_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436300.1">
        <property type="nucleotide sequence ID" value="XM_023569028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK18"/>
    <dbReference type="STRING" id="1279085.S0EK18"/>
    <dbReference type="GeneID" id="35403730"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10265"/>
    <dbReference type="HOGENOM" id="CLU_012494_9_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="3">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="238"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35729" checksum="BD4EA471ADF64229" modified="2013-09-18" version="1">MSALSYFSAVYKTVEGEDITALIYLPNSATLKPQPCPVIINIHGGAFIVGSARMVNQDQIEHCLERGWIMVVPNHRLCPGVDLLEGPITDCRDLLSWIYDKGLETEIAKNSPPNTEIRIDYDHVFASGTSSGGHLSLCLGFDVPRPPAAIFDIYGPCHFQHPFWKSKLDHIASMIPKGLTPVFMNQVYQQRPVPTEAGISLEGQAKGPDFNDPRQALCFSSLADGKLLDVVFPSGDWKKVDPLLNISESFPPTFIVHGDADTMVPLHLSRGLYSALQRSGVECGLRVIPGEEHTFAAKMKKGSQTWNLHLEGYEFLESILERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKM6</accession>
    <name>S0EKM6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable lactonohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437437.1">
        <property type="nucleotide sequence ID" value="XM_023570305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKM6"/>
    <dbReference type="SMR" id="S0EKM6"/>
    <dbReference type="STRING" id="1279085.S0EKM6"/>
    <dbReference type="GeneID" id="35404872"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11410"/>
    <dbReference type="HOGENOM" id="CLU_036110_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485728" evidence="1">
        <location>
            <begin position="23"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="207"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="401" mass="43320" checksum="FA3ED45F5BB82DA8" modified="2013-09-18" version="1">MPSTISVLAAGVLVPVLGAVAAKLPSTAQIIDQKSFNVLKDVPPPAVANDSLVFTWPGVTEESLVEKPFHVYDEEFYDVIGKDPSLTLIATSDTDPIFHEAVVWYPPTEEVFFVQNAGAPAAGTGLNKSSIIQKISLKEADEVRKGKKDEVKVAVVDSNPQVINPNGGTYYKGNIIFAGEGQGDDVPSALYLMNPLPPYNTTTLLNNYFGRQFNSLNDVGINPRNGDLYFTDTLYGYLQDFRPVPGLRNQVYRYNFDTGAVTVVADDFTLPNGIGFGPDGKKVYVTDTGIALGFYGRNLSSPASVYSFDVNQDGTLQNRKTFAYVASFIPDGVHTDSKGRVYAGCGDGVHVWNPSGKLIGKIYTGTVAANFQFAGKGRMIITGQTKLFYVTLGASGPKLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKT2</accession>
    <name>S0EKT2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (fumarate)</fullName>
            <ecNumber evidence="11">1.3.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_11467</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-dihydroorotate + fumarate = orotate + succinate</text>
            <dbReference type="Rhea" id="RHEA:30059"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="EC" id="1.3.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.1" evidence="11"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437492.1">
        <property type="nucleotide sequence ID" value="XM_023570369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKT2"/>
    <dbReference type="STRING" id="1279085.S0EKT2"/>
    <dbReference type="GeneID" id="35404929"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11467"/>
    <dbReference type="HOGENOM" id="CLU_036010_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04741">
        <property type="entry name" value="DHOD_1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="entry name" value="Dihydroorotate Dehydrogenase A, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033886">
        <property type="entry name" value="DHOD_1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (FUMARATE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="13">
        <location>
            <begin position="85"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT75446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="335" mass="35712" checksum="62E8A59C9EB21BE4" modified="2013-09-18" version="1">MAPPQLTINPPLLNSATPWATDINDLLAIASSPSTGAITTRTSLINGFNHQHERHQYLFFNPGTVTPNQGTSSSQIPPKGHSEDAMASLNNLGYSPITLDGYLGFLAEIARRLPEMRKTFIVSVTGSPEDIQQSYTRIEAASKTLPFPLAIEVNLSCPNIPGAPPPAYGGAALEKYLDLLPSNPTLPVGIKTPPYTHHGQFATLIETLLPTASSLSFITATNTLGSCLILENDKLDPQLPGTGVGGMAGPPLHPLALGNVSTLRKMLDQVPELSHIKIIGVGGVRDGDGYRRMRSVGAYAVAVGTGLGKQGPGVFERIERDLKGEWRVSLLKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL53</accession>
    <name>S0EL53_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to pyrroline-5-carboxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_11795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437804.1">
        <property type="nucleotide sequence ID" value="XM_023570734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL53"/>
    <dbReference type="STRING" id="1279085.S0EL53"/>
    <dbReference type="GeneID" id="35405256"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11795"/>
    <dbReference type="HOGENOM" id="CLU_042344_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF27">
        <property type="entry name" value="HYPOTHETICAL PYRROLINE-5-CARBOXYLATE REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="6">
        <location>
            <begin position="192"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT75758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="307" mass="32331" checksum="DD3F9343BC58544A" modified="2013-09-18" version="1">MAGLSNATLTILGTGNITKPIVQNLLPAIKDGKTDLPFTKIIACVRSEGSQSKLSEQFSEYSSILTVSRGDNVKAVQNGDVIILGVDPADIADALTQEGIRDALSGKLLISVAAGWTKEKLESTLYGSETTKENASGRAWVIRTLPNIACMVSEGLIAIEKSLTEPQVPAELMDLTKSLFNTIGRTTEVAPRLMNATTAVGGSTPAMWAIICDAFIDASVAVGVPRATAQTMIYQSMKGSAAMLQSGLQPGDLRDQGTSPEGCTIGGIMVLEEAGVRGHLGRALREAVTLARLMETTTHVNDTRPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELA6</accession>
    <name>S0ELA6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to Transaldolase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436765.1">
        <property type="nucleotide sequence ID" value="XM_023569568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELA6"/>
    <dbReference type="STRING" id="1279085.S0ELA6"/>
    <dbReference type="GeneID" id="35404213"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10749"/>
    <dbReference type="HOGENOM" id="CLU_047470_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF39">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="356" mass="39552" checksum="B39BD4FBDB44B904" modified="2013-09-18" version="1">MSTVTWLDKLQEQVKIDIDCMDPEEAKRFLPFKPHDQTSNQRLVYEQMVSPENRELFLKTVKKGKDERWEVILDRMSALLCARNIENIQGRVLLQTSAFHAYDTTKVVAQARSYVCELEKLGISKDRICIKIPCTGPALNASPILLREGIRTLGTSLFSVAQAIAASQAQTLSISPYYNLPWYHTDREQWPDAQDPALDHPMSPRVVQIQQVYKRLREETGKTQPLLKPASFISAREAMAMAELGCDHATLPEDILLRLSQLDADANPPPGSDSGMKTGAPSQRIAHLAQTDPLAGSNWSGLPALDIDYLADNGAALTEAIAADTVAQRGLDQALEAFKANELQSRDAIEEVLKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMM0</accession>
    <name>S0EMM0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437215.1">
        <property type="nucleotide sequence ID" value="XM_023569624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMM0"/>
    <dbReference type="GeneID" id="35404264"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10800"/>
    <dbReference type="HOGENOM" id="CLU_1023215_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29521" checksum="625B10146CFAAE25" modified="2013-09-18" version="1">MASELPPNALGKLASSVKNIVTGVPLEDQNESNAPATKQVGKSLDKTVDKTVETTDDATIHKEKQAPVVHEDVKSHEHERVDTEIDHEVHQDHYHTTIQPVKDKNVLPTKHVYKENEFEEEIDHRNNEAKMKAKEEAAKIKNEKNVEDTTQSREYAPTKENEHIHHHLHENIQPVIERETVQQKVIHTTNRIHEKEQLNDEYHEATVAPAISMDEFKNGGAKTGTTVTKDIEMPVSGIKATAKKREALGDVDVEEGSKVESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN07</accession>
    <name>S0EN07_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to SKI2-antiviral protein and putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_14135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438277.1">
        <property type="nucleotide sequence ID" value="XM_023571228.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EN07"/>
    <dbReference type="GeneID" id="35407587"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14135"/>
    <dbReference type="HOGENOM" id="CLU_002305_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18025">
        <property type="entry name" value="DEXHc_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="736"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1152"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1134"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1667"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1667"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1702"/>
            <end position="1722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT76231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1761" mass="199001" checksum="2776786403ABF71C" modified="2013-09-18" version="1">MASTDMKPFEEALLNWYKGLQPLTVDIVGDFAGRELFLIHGEALMQYCLIEARVDFDRGFQLLHAIQAVEKFLVNLKNGDCNFDIVFFRDFENVCAYEGSAGSKYPYKFKLTRRILIQHLTRGIADFKILEFDSFDSQECRMYLANNAIHFMLCDDGRGASLDQSVRLQHLIWKVISSGRNVALINSISWKSSKIFMPLLSGSKGALPDLHIDTPVCETEPLADFSKQVLDETLRLSNETLDISAREKFAAVFCRVFLERSSKEGEISGVDLELVEALLLHMATLRVCHLQNRNVHPERLSKHVFDSYDTGFVQLFCTASQTLAENGYAVRGQAEWDLFDLFDGHIFFYILHAIRDGSEFPIPIVDRGKALSAKVLGQRSMNGRSLFMALKTLESNLPPVPPHSTPTVLSFNHPVLNEFLEDVWVKEVPDDVDPVAEIVFQDLRHWHAYKPITTSTRMTHEKVPVWLENYRRKRLQRQMADVILYAASLSNSVGKVFSRETIVVGAPTKQKLARGGVDADTNSKRLAKVGNQSPRGGKQKALLAACALNEKRALAKQNDALHLWAMKCAEIENTDNPVKQYLKALDYLSDGSPGSHISVKPEVLLYLCHILRRIWDQTRKQVDEDSPKGLYLISMVWNWLRVISISDKCTPDVASAAQGIMKALAISRLSITVQEPPRKLPFTILPWITMKDVPRLVQDHRLLQLRHGGPHMDRRFDSRPDERVPFEPDAWQRDILDSIDADESLLVVAPTSAGKTFISFYAMKKVLEKSDDEVLVYVAPTKALVNQIAAEIEARFSKRFRTQEGKSVWAIHTRDYRINNPARCQILVTVPHMLQIMLLAPTNASSPTAWSRRVKRIIFDEVHCIGQAEDGIIWEQLLLLAPCPIIALSATVGNPDELRDWLSKLQAKKGFKMKMIVHEVRYSDLRKFIYEPPHDFSFKGLAKVSRLPVPGLDEGDSISPNFKNIAALDDVTLEARDCLTLWNSMQNTFPKDLLGNRSELDPLKVLPEVIEKSHIVEWEKSLKRKLKEAMENPESPFYDLQESLDPSVQNERTSKISHDVHSDSVDHIDRLFTLACELHSQDALPALIFNYDRSECEMAIRSILSKLNDAEKAFKGNDTTWKKKLRDFEQWQRQKGNDRGIRFPKRSENGERNPSKLEIAREEGSVETSPWESFDPEAPLDHFSFADTKKMQQKDLDDLVLRLDPMKVQPWLIDALRRGLGVHHAGMNLHYRRIVEILFRKGYIRLVVATGTLALGINMPCKTVVFSGDSVFLSPQNYRQASGRAGRRGFDLLGNVVFNGISRDRVHEIMSSRLPALKGQFPISTTLVLRLFVLLNGTNNNEFAVNAVKSLLSQTRLYLGGPDAEMAVKHHLRFSIEYLRRQNLLSVKGVPIHFAGLVGHLYFTENAVFAFHSLLRGGYFHKLCKDIDSDRERVLREMMLVLSHLFSRIPIQQKAKALEIVESSSSDIFLKRLPVAAEQLLVRHNRETLLTFKDYVSSYINAHLHDLPDCTLPLTKIPIGPEKGRGCSLTSDPPPVIRSPFVALSGFTDDFNSIKELCSTARDGVFLEESSIPYLPIWPIDTTVELNAYLYDFFKHGSLKVLVRDNHIKRGDVWFHLKDFSLVLKTIVTSLKGVIDSGGGFFMEDLDGDDNMSDMSEGDHEAISEVFEVQKPDKAPEETEKSLAKDKAKPEVPDSWEDESDASTSESEGPMPGSGVSGSSASKDPAGMQSGFDNGCGLMQVLRAFELLEAEFADKFYKIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN46</accession>
    <name>S0EN46_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to proposed vacuolar iron transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_11393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437420.1">
        <property type="nucleotide sequence ID" value="XM_023570286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN46"/>
    <dbReference type="STRING" id="1279085.S0EN46"/>
    <dbReference type="GeneID" id="35404855"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11393"/>
    <dbReference type="HOGENOM" id="CLU_038957_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT75374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="255" mass="27347" checksum="EFE086810A5C2F6B" modified="2013-09-18" version="1">MKSSQSPAFKRFLSDFTLGFSDGLTVPFALTAGLSSLGKTDTVITGGLAELCAGSISMGIGGYLAARDECAPCKPRNKDLENLRESYERNSESDCMVEQSEKIQMQAEELVRQHLEPLDLPSSTVTTILNTIQQEPSDLQRVVSRLNTLKDDVSPSQPTPQSPILSGLSISLGYTIGGIIPLFPYFFTSTVGLGLQWSSCLCLLVLFAFGAGKSYILQTGDASMRSWMIEGFQMLILGALAAIAAVACVTWVGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENL4</accession>
    <name>S0ENL4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to potential drug facilitator PEP5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_10240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436276.1">
        <property type="nucleotide sequence ID" value="XM_023569001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENL4"/>
    <dbReference type="GeneID" id="35403705"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10240"/>
    <dbReference type="HOGENOM" id="CLU_000960_25_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT74198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="570" mass="60660" checksum="6D2464C51455149C" modified="2013-09-18" version="1">MEDGDKASISHNEMPVTLEPNASPLVEEEPAGGYHVRWKTLMAVFALSMANCCAAIANTTNTIIHFQVMDLGGADKQAWISNANLLVTLVFGPVLGSLSDRFGKKWFIVIASIIGIVGSVVSGSAQSITTIIIGNILTGLANAGCIMGVPAGQEVTPNKLRPWTMGFSQTLASCAVIAGTLGAGAFVKYQTWRWSYYLNAFVYGTTTVLVTCFYHPPPTTLRRQQSRLDDLFAQVDYFGIMLFVGSIASIMIGLTWGGNTYPWSSSQVLATLIVGCIGLVAFGLYERLFTRQGIFHHDLFVSRNFPILLFVCVVDGMLLLGVNILFSQQIAAMFTTDAVKIATILTPYLATSAFGCLPAGMLMARTKSYRTILVASLIWCSLFVGLMALLNPSRLSWAYAFSAMFGCGTAVTTVIPVVALSLSVPSYLLGTAGTLSVSGRALGGAIGITIFTSIYHNKMGTALPKAVGSVLAAAGQSSLLPDVLSAINSGNPTALSNVPGLPASLIPKVLAANDHANTYSWRFVWIAISVVVAANALAACFLKSVASQMNSHVESALEDSDVRRKQMRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP93</accession>
    <name>S0EP93_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_14127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438285.1">
        <property type="nucleotide sequence ID" value="XM_023571237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP93"/>
    <dbReference type="STRING" id="1279085.S0EP93"/>
    <dbReference type="GeneID" id="35407579"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14127"/>
    <dbReference type="HOGENOM" id="CLU_642580_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="79"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT76239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="472" mass="51792" checksum="F9EFA5129A0E3275" modified="2013-09-18" version="1">MDLPRRSKRLARKDPVIETASSWDTPVPAPRLQQIPHQLSGPSSAPGKHAQQLVEQRYQEKDELATCPSITQTTQNIEWSLLQRVAGFQHADQVEASVLSPISVLIAVAMLAGAADSHRRSQLQQKLGVAEGLEAHVSLLHADLAPLAKQDIISLANAVFVDQSVEIATKYKKYLEAFQAQSWQFPSLADSVKDINSWISQNTLGRITDLLSSRALRKCHVVLANATAFRGTWKTKFNRDNTVLEHPFHLENGSIRAAEMMFLYKEYVETASSSNYTAVRVPYATESDSSPAALVAWLPNPGITIRSLVEQLSTTKSDGPSFRRRKLSKFGFPKFETRSKVSLMDELAGLGFPIKGNYPEMGSGPTEVTAISHEASIKVDEEGAEATAATVVMVARKRSTVVSEEVLDEKRSVPTAQNNTEPTPPTYNLDLTNSSTFLYGFPSRAVNTTTGMSPDLINLQAEQPSEDDDAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPE1</accession>
    <name>S0EPE1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to 1-acyldihydroxyacetone-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_11032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437036.1">
        <property type="nucleotide sequence ID" value="XM_023569883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPE1"/>
    <dbReference type="STRING" id="1279085.S0EPE1"/>
    <dbReference type="GeneID" id="35404496"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11032"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF3">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE SRDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT74958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="289" mass="32395" checksum="6BC6B4F8B48E88D6" modified="2013-09-18" version="1">MARPKFALVTGCGQGGIGEALVMEYKRLSMHAIATVLPHESSVHLSQAGITCFPLDVKVEDSVSELKLKVQELTGGHLHILVNCAGIAYTMTAIDTDVIVVQRMFDVNVFGPMRMVHHFHDMIIEASGTIVNIGSIGGTIPFVYGSSYNASKAALQHWSNTLRVEMAPFRVKVITVISGEVNTNILKADAHRRLPEGSYYSALAKEFEQHVLRKPKNATDRLELAENVVKESLKSRPSAWFWFGSFSTLTRFLDTFAWRAIWDSILWRMFDMKKLQRAHAARFQEEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPU1</accession>
    <name>S0EPU1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_11776</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="2"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437786.1">
        <property type="nucleotide sequence ID" value="XM_023570713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPU1"/>
    <dbReference type="STRING" id="1279085.S0EPU1"/>
    <dbReference type="GeneID" id="35405237"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11776"/>
    <dbReference type="HOGENOM" id="CLU_023643_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="377" mass="41821" checksum="ECC1A833C2D7E4F6" modified="2013-09-18" version="1">MASSAPKVAPPERRDPLDVIDKQADEIVALIKKSKHFIVFTGAGVSTSAGIPDFRGPEGAWTLRAQGRARTGKATSTLQAIPTPTHMALVELQNQGVLKYLVSQNCDGLHRRSGILRDRISELHGNSNRECCKDCGKEYIRDFRAVASYEKSVHDHRTGRKCTACGGNLLDTIINFGEFLPEEPLKLARSHAKKADLCIALGSSLSVPPASGIPETCGKSKKSKLIICNLQETFMEGIADMHVWAESDVLMTRVMDKLGYTIPNFILKRRLVIKVERDVYNRQVIVLTGVDDDGTPVTYLQSVKLEDSRRIVRSEPFSFVFREGLSTGAEVKFALEFMGHYNEPNVVIDYSVPEEEGAETVYDLSYDPSTGEWVIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPZ8</accession>
    <name>S0EPZ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to hexose transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_12087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438071.1">
        <property type="nucleotide sequence ID" value="XM_023571059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPZ8"/>
    <dbReference type="GeneID" id="35405547"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12087"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT76025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="515" mass="57449" checksum="D062B270056B50EA" modified="2013-09-18" version="1">MADALGPSTHWWNDAGLRKLYLWLPVVILSSSYQGFDGMIMNGLQLLPSWQEEFDHPEGPVLGLLNSIQTVGAMLALPFIGWVVDKVGRRKSIAFGASWTLLGAILQATSKHIAQFVISRFIIGFGLAFTVVGAPLLLAELALPKHRGTILSYFPTAWYTGAIIAAWTTYGTQFIEDSRSWRIPSGLQAVPAVIQITLLWFIPESPRWLISKGNGAAARSFLVEHHANGDESNPIVEIEYTQIKQAILQDAQYKEQGSYLDLIRTKPNRRRLILVTFCGLFLEISGNGLVQYYLHSVLNSIGITKTIEQTTVNGCLSIYNFVLALGASFLVDRIGRRKLFIISTAGMFFAFILWTTFAALYTEHGTRNYAIGVIVSIFLSNGAYDLGWTPLWAYPAELLPYEVRARGVAYMTGIMHAAGFFSSFVNPIGLKNAGWKYYIAFIVYTFLELIAVWYFFVETKGYTLEEIDTIFETPGLTWKQRRNLKAPSLVRETSSIEESGDAARKSDVAVSKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ43</accession>
    <name>S0EQ43_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="9">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_14115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="9"/>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438296.1">
        <property type="nucleotide sequence ID" value="XM_023571251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ43"/>
    <dbReference type="STRING" id="1279085.S0EQ43"/>
    <dbReference type="GeneID" id="35407567"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14115"/>
    <dbReference type="HOGENOM" id="CLU_029332_3_0_1"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23399">
        <property type="entry name" value="beta-trefoil_ABD_ABFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000059">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027135809" description="Alpha-L-arabinofuranosidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B catalytic" evidence="11">
        <location>
            <begin position="24"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B arabinose-binding" evidence="10">
        <location>
            <begin position="357"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="85"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="407"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT76250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="506" mass="53526" checksum="D0FF1B78A53D39C3" modified="2013-09-18" version="1">MTFRKTSYLLSGLAAAGTRALSGPCDIYADGGTPCVAAFGTTRALYGSYSGPLYQLQRGSDGQTTNIVPTSPGGVADVSVQDTFCANTTCTIPIIYDQSSKGNHLTRAPPGGGSKGPAPGQYDDLAAAYGAPVLVNGKKTYGIFVHSTVGYRNDKTTGVAVKNEAEGLYAIFDGTHYNDKCCFDFGNAETTNHADDNGSMEAIYFGDDTEWGSGAGSGPWVMADMENGLFSGQGAGYNPGDPTIESRFVTAFLKGNSTNLWALRGGNEKSQSLSTYYSGPRPNGYYPMDKQGAIVLGIGGDNGNLDQGTWYEGVLTSGYPSDETEDAVQANIEQAGFTATSLANGPPLSVGSTITIKATTPGFTNRYLAHDGSTVNTKVITSSSDASTKQKGSWIVRQGLVTSALGCVSLESFDTPGSFIRHSGFTLYPNANDGSKQFSEDATWCPQQSFDSAGSNALRSWSYPTRYFRHYDSTGYAAMDGGWEVFDASTDFTDDASWFISSSFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHL0</accession>
    <name>S0DHL0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to dna mismatch repair homologue (Hpms2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423765.1">
        <property type="nucleotide sequence ID" value="XM_023574273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHL0"/>
    <dbReference type="STRING" id="1279085.S0DHL0"/>
    <dbReference type="GeneID" id="35395321"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01838"/>
    <dbReference type="HOGENOM" id="CLU_005415_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="606"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="858" mass="94246" checksum="A8C48A66CBE8AD62" modified="2013-09-18" version="1">MIIRQLPQDVVDKIKSSVNITSLNGVVCGLITNSLDAGASKINISIDYSRGNCTVEDNGSGIPPEEFKDGGGLGKLHHTSKFPSRSSVHGKHGNFLASLATFSLLAITSHHQRHISHNSISFHNSRILARHLPSLPESRLVNFDHGTRTTVRDLFGNMPVRVKQRVTFAERSALDKEWSRLVRAVVALLLAWPFGVSVSLKNTGTQRELRFRSSDKADIMSRTSRLLTQAGLADSDDADTWVPISASCGPISVKGAISTNPVATRRSQFISLGIQPVSNDFGTDVLYEEINKTFGNSSFGVIDGDEDHNGNSPKLEEFTGRDLKSRKGIERWPMFYLKISTTGSEGLGNPDRLDSQGQTLSAIIDLLKATCYGFLKKHHFRPQKVRLAPEESLFSTARTLGRSKKPKKQPASSSNSSRASSATPVSRSGSLGARADSPFEGWHRVKVGRATPLSATSKAADVRTKMRDESSLGRLVGEGGKLLRKPFDEPFPEPEDEKTGSSANSGVMLDACTIDDTTGGSDTSSSVTCQGAQKRDKHPSKWLQSVISSWENPIFHPAEALVPCIDGSAQDQLHTCGHGGVHVGFETGSMSLSGRISRHALAHATVIEQVDRKFILVKLPLERAVSGTLAHEKQSSALVMLDQHAVDERCQIEDLMASYFTHDPLTNQTSPVIENLDRPVIFEVSKEEWFLLEQYRDYFAAWGITYQTPISSQNKIIVTGLPPSIIERCRLEPRLLIELLRTEVWRSVDSSVPLVRPPTTTTTPDKPLISRFNGCPRGILELLHSRACRSAIMFNDVLSVNQCEDLIDRLSRCAFPFQCAHGRPSMAPLIDLGNGGKFGGWQESKRQKAVSWKSWLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHM2</accession>
    <name>S0DHM2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423576.1">
        <property type="nucleotide sequence ID" value="XM_023578450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHM2"/>
    <dbReference type="GeneID" id="35395509"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02026"/>
    <dbReference type="HOGENOM" id="CLU_1057863_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="274" mass="29912" checksum="0119B3C7BCEA7C57" modified="2013-09-18" version="1">MSNYPNYYPPPGHPAGAKTYHPSPMDPPYYEAPPHAPPPGYQQPIYPPQPGSSGIQGPPNYYTRVGFTRLPAKFHIWNVVTSSGASCLELGPQLKGPLAYSAKMFSSNRLKIKEGPYASENLPICTIESRHMFSSKSTITFDGFQANFVETSVFNDGATWPFDVEVNGSSQGWQWRRKKTQKQSTVGQIVEAFSDSDFGSWELVPGLGQSWPMATFEATGGNTFEDNAALGVFEFHGPAAIGQLGDIFVNVSIAILLRIISQHYISRIAALAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI49</accession>
    <name>S0DI49_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED8</name>
        <name evidence="11" type="ORF">FFUJ_01710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI49"/>
    <dbReference type="STRING" id="1279085.S0DI49"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01710"/>
    <dbReference type="HOGENOM" id="CLU_074399_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT61800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="261" mass="29697" checksum="9D8ABB78C786390B" modified="2013-09-18" version="1">MATLNLDDDELKALEQTLSKVAQLSSSVQSFRQDLIKSNPLPPPKSIQASAKILQKNLKSLLESTNENADLFNRMAIRPSTNYPGRTQENVLLQLLRKKLEPDVEEFVSQGLETARLATPEGLESLEQIWRELRSWLSDRVIHFISTENSDPYTAEERANGVKNVRTGLRRPIDDDEEEEDEEEGDEEEDDDEPEKPDVPEVKVRGAEPETLLWFAARGDFEVPRNVEYERKVDVYKGLQGVNIPPSDQQQQQPQQGFVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ98</accession>
    <name>S0DJ98_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_01090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424446.1">
        <property type="nucleotide sequence ID" value="XM_023567808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJ98"/>
    <dbReference type="STRING" id="1279085.S0DJ98"/>
    <dbReference type="GeneID" id="35394575"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01090"/>
    <dbReference type="HOGENOM" id="CLU_063073_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494886" description="superoxide dismutase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT62365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="265" mass="27992" checksum="F94E141BEC342902" modified="2013-09-18" version="1">MRTQAMVAVLFSALAGQVFGQDDSHDAPRVNDNPIGVKYKATLPKEPFFKDAAIDGNVKGFIQAEAPSDGHGVQFKVQFSNLPKEGGPFTYHIHVEPVPENGNCTATLAHLDPFARGEEPPCDPEKPASCQVGDNSGKHGKITSDPFTADYIDYYASTKEGIGAYFGNRSFVLHYANKTRLTCANFVNLNPGVIDSNYTAPAYLPTPTETVNPETNTPTPSSTGSGTGGKPISTETSVVSPNGASSATLPINFALAGVLALILAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJM0</accession>
    <name>S0DJM0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423568.1">
        <property type="nucleotide sequence ID" value="XM_023577561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJM0"/>
    <dbReference type="STRING" id="1279085.S0DJM0"/>
    <dbReference type="GeneID" id="35395517"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02034"/>
    <dbReference type="HOGENOM" id="CLU_093550_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494894" evidence="2">
        <location>
            <begin position="19"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="265" mass="27926" checksum="FED2C07718B89CD0" modified="2013-09-18" version="1">MHSLAAYTLLASASLAVAIDPRFEFPDTVPLVKRQQPGTPQYACHEDCGLLITLARDDSDYCDSDEWNERYGRCMSCANTYDIWKYYGSGVGRVAQSCGLTPKPSPSGSSGAASTTAEEKPSSTAAEAKPSTTAVEKPATTAVEEAETTKAEEQTTATEEAEAEATSEHEHEHEETEHAHTSTEAGHSEAHEHTTLATHAAETTHAANPTKTHEAGHTSVDEIGTVGVTATSTPLPSTVIVNGAAKQIGFSTAMAVVALAMFGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK79</accession>
    <name>S0DK79_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424852.1">
        <property type="nucleotide sequence ID" value="XM_023572774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK79"/>
    <dbReference type="STRING" id="1279085.S0DK79"/>
    <dbReference type="GeneID" id="35394128"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00643"/>
    <dbReference type="HOGENOM" id="CLU_060561_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056143">
        <property type="entry name" value="DUF7726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339:SF1">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24852">
        <property type="entry name" value="DUF7726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7726" evidence="2">
        <location>
            <begin position="178"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7726" evidence="2">
        <location>
            <begin position="285"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="418" mass="45705" checksum="BA94523DDD67DE58" modified="2013-09-18" version="1">MSGWSWSPRQAMLQMSQPEMNHQPHPTIPPQSLPSMPALNLPHPPAPNPALPVYNKPGPLPVSNNPVPPPIPVPVPVPGPIPNNSTSPAYYNPPPPFVPHSSGAQAPGGPPPLVNTSSMARGNPSGAPPIPAPAPAATTKSSRKRRSDVGPDNAQENLFPDNVPDIDSEDERLALHDSDTCNAIRRKIRNWIDSGAQKVGEFQKTIGVSGKSYNSFMNRTGTWDGENTDTYIKAHLFFKKRELQGLPLKANKPKKAKTAASAKALEEILDVSNVDPLPGEADGTVPVYDTCDEIRKKIRPILAKEGMTQAAFIRALNKNLPEGKSVSPANMRYFMGRKGVRDGNTNITFYAAYVFFEKKRIQAGKPKTQFRQKMEKAWGNKGFDIEHGANQQYTCFAGEEPVVDEFGKIDFVVTGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKH3</accession>
    <name>S0DKH3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425155.1">
        <property type="nucleotide sequence ID" value="XM_023573429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKH3"/>
    <dbReference type="GeneID" id="35393801"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00316"/>
    <dbReference type="HOGENOM" id="CLU_1261605_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="219" mass="25487" checksum="B6CD215D68879C90" modified="2013-09-18" version="1">MFGTQRFPIISIENHMITSPLDRYFPGVLDTIQQGRPSKRFYGGFQQPWTLWMARCPRCTKWQELRAFRFDAGAGPGFQAWEPDMGRLTWDGVILTQEIFDKACCNACFMEQNGQSALAEYLCRWFVFLVKQQPEDVQSELLSEASRFMTNYGAIIHPTAFQDWNQTCLEIDSSRSQGESPWHLSPRSQLLFKHWFRIFGLAADAFPDDPRGQFHKQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKK4</accession>
    <name>S0DKK4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_00474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425002.1">
        <property type="nucleotide sequence ID" value="XM_023573254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKK4"/>
    <dbReference type="STRING" id="1279085.S0DKK4"/>
    <dbReference type="GeneID" id="35393959"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00474"/>
    <dbReference type="HOGENOM" id="CLU_032067_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT62921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="492" mass="55303" checksum="0CED34D79EF937B0" modified="2013-09-18" version="1">MEESSEHHDILVIGAGLSGINTAHVLNQRLPHRSYTILEAQSAIGGTWRFFRYPGFRSDSFMTAFGLPWYPWKHKHKMAQAGEIVDYLEEAVDAAGLRDKIRFRHKMLACEWRTDEQNWKIEVDADGQPKTFIANFVISCVGYYAYDKAFPTTIPGLKGFGGQVVHPQWWPEDLDYSGKRVIVIGSGATAITIVPSLAEKAGMVTMLQRSPSFVISRPTTSSLDSCLKYLLPFSLAHWFVYWKDVLLEVFSTQFLLNFPALGRKVLMGEMQKALPKDIDVNVHFNPRYNPFQQRLCMCPDEDFFKALHQDNCEIVTDTIETVTKDGILLKSGRKLEADIIVTATGLYFQLFGGIAPLVDGQPIEVGSHYAWRGCMVDSVPNMGFVMGYVTTSWTPGADIMAKTLISVIKEMEKTGSTSVMPVLDEKDRSKPQKLPVSATSSYFVKAADRMPKVTDEGPWYGRVNLAKDWWAWLMGDMSSGLLYSGGQRKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLH1</accession>
    <name>S0DLH1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425357.1">
        <property type="nucleotide sequence ID" value="XM_023573682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLH1"/>
    <dbReference type="STRING" id="1279085.S0DLH1"/>
    <dbReference type="GeneID" id="35393576"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00091"/>
    <dbReference type="HOGENOM" id="CLU_297720_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1011" mass="115073" checksum="AE5EF0D0895B9A4F" modified="2013-09-18" version="1">MAYYSSQPPPLPKIEASQSVSIPKNAQRARREITTLQAVEEPEKQNFPTLCSSEDTLLRLGHLLQSFHCGRVPIDLLTRACGPKMTWSSAGEVVEKHPGEREVPEWLVDFYQANKPWLRDLGQEPPNRIFKIISDNNIRYLQARGDGSPISGHEQHSPLVNERKLAHVRIAMALHAFPSINSEIIGEEMVDRLMDTAKTSVLPLLSSLTEADIQDWLLPERLDETNAMILYTLSMLLPDDTILAGTGAVTERLSNALPNWRALSPTDRSTMEFLTEASLSGNSQLNVNRRFIFKTVDAQALYGFQLSQHKQYDKAIMFLRATIADVTSKYGETSMQVGLVTAELANCYNILRKEEKAEECILTTIQTRKDWRLSTRRDGIYLRLALADSFIGQALYSEAVPMLESIIQTHDISATFRMMSVLRLAKSRRRMHESAEKAFEHDSPLWTGSTLLSHVSQVLEMEYVEELACSISEMHNLPQNISEVACELLEAVDSALCKTASLNDSPSWGWYSKVKKEYLGRIEKDTELKKDKGKGKGADEDTEESGKNRECSPVSSLFYSLREEADMYRERPWSEKLALSFDLGGVRTLSSLLILKRIMHRIRELENDHPDGPVYSSSSYPWMGDQSGIPSEPGRPDQIDEFLPCHYFDYIAGIWSAMMLGRFRMSVDDAINSFISIISHVFSQSRLFHQMPLFPFIERAKYSIEEAREVHERLGMQYQRRWEREDTKDAFDGKDQLFWQPRYGTKVMVMSFSVRNGVYEEIIFTSYDDPYNYHFTAGLRPIHSFTAWEIMSATSAGLPYFDATRIDNVTFGFTKWLPHNPTQNALKRISSLDGKWPAVLVSLGAGGSERIPSLLLKPDRRLKGDKQPKDVFPTFGGVMGIQHSYRLNVQGILGQIPFDDWQPRESGETTIQVIKDITERYLDTAEVEVDIDLIAEEAVRIRRARAQTERWEAFAINVEYTCSLCPRPTSLVTTDRADLRGHLEACHKGWSMSNQEVESLLDENRTYRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLV6</accession>
    <name>S0DLV6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423599.1">
        <property type="nucleotide sequence ID" value="XM_023581005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLV6"/>
    <dbReference type="STRING" id="1279085.S0DLV6"/>
    <dbReference type="GeneID" id="35395486"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02003"/>
    <dbReference type="HOGENOM" id="CLU_585317_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46359" checksum="CE6EB9B80E943EBB" modified="2013-09-18" version="1">MLICIPFLVPNEDIFLDRFLIDLKDNGFSTQAASLNGVILQGGKLSQRPDTPIFISRNQKNRSGLSSEGLRLPPSVSSNQFLKDEEKQSPQFPSRSSTPSKRRRTAGLSDDLYDLDEDGDNSPNEIVKRFACPYFRKNPERHLECINLKMVRISDVKQHLKRRHTARYHCPICCEGFSSLNLQGNHILQQTCVQGSGANWDSVSPASQKALQARFGKTLSPEAQWYGIWTILFGERRPMPNPHLDGVVKEVIGILRGIWLDEGRRLISEFVEAKDQPTSYNDQLYQLLAGVLDEVEARFEQESSEKISSKTSVVSEPSPEESAGVQLDTVSRYITEGPDSQSLVAPYDTTSLFFDFSAAPSEVSEVSYQASEFGFSGTQLLQTRYSYPDNPVSDFNLWDCNQQQPIPMDGAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLV8</accession>
    <name>S0DLV8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_00918</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425511.1">
        <property type="nucleotide sequence ID" value="XM_023569718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLV8"/>
    <dbReference type="STRING" id="1279085.S0DLV8"/>
    <dbReference type="GeneID" id="35394403"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00918"/>
    <dbReference type="HOGENOM" id="CLU_153999_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT63430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="74" mass="8135" checksum="E4BFB73AEFB321B8" modified="2013-09-18" version="1">MPTSPHSTYYDRRLRQGPALVRARRPYLVKNAVTGLGLLAVVGSIYWYTLNAVGQDNFEDVKVPDAPAKSSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMM9</accession>
    <name>S0DMM9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_04970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425945.1">
        <property type="nucleotide sequence ID" value="XM_023571680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMM9"/>
    <dbReference type="STRING" id="1279085.S0DMM9"/>
    <dbReference type="GeneID" id="35398451"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04970"/>
    <dbReference type="HOGENOM" id="CLU_040936_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="325"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT63864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="382" mass="43341" checksum="4100895B6FAF5FB8" modified="2013-09-18" version="1">MSEQPPQPGPQPGQIPMPQPGQRPTPEQIQAMQRQLAIDAEKNGMTVPEFIEHIKRQAQEQMRMRAQQQQQGHDHDHDHNGHSHDHGQPPQQGRAQPITPGPPNPKAIALASFLRGQDLKPRTVILNGERKDMFRVKRALRALQSPAYEKARKKNPLLPEITDRASLENTFKLLPLSMLALRVSKVEPQAGPNGKKPKRVKGQWTVKIEQQQEAKEDMYYCWLWEGSQLKRKIYAGLALLAIFAIVLYPLWPLVLRQGVYYLSWGLLGLLGLFFLMAIFRVILFCITYFTTPPGLWLFPNLWEDVSFMDSFRPVWAWHETEKKKKKKKSAAPGTTPNPAFAAATGQVNTSATTTGTDTQVKTGGVQQRHYEAPRVEELDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN57</accession>
    <name>S0DN57_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to inorganic phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424069.1">
        <property type="nucleotide sequence ID" value="XM_023577961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN57"/>
    <dbReference type="STRING" id="1279085.S0DN57"/>
    <dbReference type="GeneID" id="35394990"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01505"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_13_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="637"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT61988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="670" mass="75866" checksum="985572BC08F03AAE" modified="2013-09-18" version="1">MVHRHHHHESTIPGEIPVPHGPPDSDSEHVSDEPIAYATADERRIFSHVTRPDDSYTEDGVYWADLPLAQRYRFVSKVDNEAAKEEAKTAWSMFKEDPLSPFSWYFRHAVIPGAGLGLEGYVLFSIGNLEPLFKAVWPDCWGKEPTTCSHNWIASVTYLEIIGIMVGQAVVGVMGDWVGRRWGLIQDAAIMFIGLLMLTASWGLTLQGWVICYAWSLFFYGFGVGGEYPITATSSLEGVSSGGRISTREDRLHRGRRVTTAFLMQGWGQFVNQVILIVLLAIFNNGKSSPPYSKSAAQYTFRLSFAFPAIGTLWLLYYRTYRMRSAGKQLAEAKKRSNVTGYDVNALRHCFTNFGGRLFATAGTWFCNDVFFYGNKLFQGQFIKVISPDSKSIFTTWTWNLVNITVSLAGYYLASLLIDNKMYGRKMMQQVGFFMCFLMFIIPAFKFDYYTSPAGIHSFQAMYFISSFFNQFGPNSVTFLVAGEVFPTPIRATAHGFSACIGKSGALLASVLYNYIDDQTKFYVVPWFGLAGMLLTWIFLPDTTGLDLKEQERRWYYIRDGKESEYHGVAVNPTHLSLWERFRGLGKSYDPEADWRAKVQDMRTEWELVQASRGPKDTEGAMPDDGEFSPEIHEFFKRSSPKHIGRRDESLMVDPINEKTAVPSDDSNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPC0</accession>
    <name>S0DPC0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_00127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425328.1">
        <property type="nucleotide sequence ID" value="XM_023573640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPC0"/>
    <dbReference type="STRING" id="1279085.S0DPC0"/>
    <dbReference type="GeneID" id="35393612"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00127"/>
    <dbReference type="HOGENOM" id="CLU_050461_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="273" mass="30290" checksum="C258AFD9E0E6074D" modified="2013-09-18" version="1">MISKLYKPEEEVCVSIPTRLNYTFLRKTTQYGDGREQQLLDFVKSHPRLNLMENNPSEALSAIDEFGHQENFLMNVGKNKGAIVTNIIAERSPALMVELGGYIGYSAILFGDALKKAGGQKYISLEINETFASVASSLISIAGLNDIVEVRVGPCVASLQRIREENLNLQIDLLFLDHQKSAYVADLMLCEELSLIRSGSIVVADNVISPGAPFYLDYIRGSQQEKEQLRGQLAKEDERLLRIGNCSLKYTSRLHKGFEPTGEPDGIEESVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPN7</accession>
    <name>S0DPN7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426491.1">
        <property type="nucleotide sequence ID" value="XM_023572354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPN7"/>
    <dbReference type="GeneID" id="35397850"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04369"/>
    <dbReference type="HOGENOM" id="CLU_057363_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="388" mass="42890" checksum="1F36F7B391F993BC" modified="2013-09-18" version="1">MTPPSRQRNPALAGRPGRLKLSVEEAIRQASPRSRSPSTLSPISKDRSRRRSSSSTTSHTVESFRRRARSDRYFDPLGFQTQTNQPETCITFPPLGSQDSSPFPRLSVDESAVFTDEEPPSQGQSPISPLSGPNWQMPAQPLRTQSARVKHEQMIRVTLKTQTTEVPCIAKCYLTRDSSVVDNDFARNWGVKIHPVPKPRWKDARHWCELDVIDVETIGSVQKQLSIRLGKLPDQRVSVELGIDALKALHLVDETANPKIEQLSRSAPPSQYLSWTGISPPYMQQPQDILGPYVLTPPVSQQYTTGRNRALTVPSIPSIRIDTSFDTSLSVPNSVGDSGSCEDSSSPWDWDALSIASQSYQEEDPSAAWSPAVSDCGGLSSSFDTCMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPY5</accession>
    <name>S0DPY5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to acetyl-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426695.1">
        <property type="nucleotide sequence ID" value="XM_023572602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPY5"/>
    <dbReference type="STRING" id="1279085.S0DPY5"/>
    <dbReference type="GeneID" id="35397628"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04147"/>
    <dbReference type="HOGENOM" id="CLU_027519_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="157"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT64614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="477" mass="53025" checksum="B4DD608051E72B22" modified="2013-09-18" version="1">MDSATLETVRTVVPLLPLIVRQGLAHLLNLSDSSKYLDLRSAIIIACLRVILTPKAPRSISSVQRLTLRDSGVKGHIWVSKYASPQPPETSVRDALISTLEHLGGSTCRVPVPDLVDVEAEWTGYRSGVARGAPLPDVSERERYHGMMQECKKPTTVLYLHGGAYYLCDPATHRPTTKKLAQLTGGRCYSVRYRLAPQHPFPAALLDAFVSYLTLLYPPPDAYHDPVQPEHIVIAGDSAGGNLSLSLLQLILELRRQDSPILWHGELRQVPMPAGVALNSPWLDITQSSPTWEMSTPTPCDYLPKPEATKKRTVPPCEAWPANPPRRNMYVADDLAAHPLASLVMARSWKGAPPIYLCTGWEILAYEDKFLARKLEADGVRVVFEEYEGMPHCFAMMLRNAPATPRCYNGWASFIRAAVEDPDSIESSAVMIRAKTCEEVPLRFDQLSDVSEEHIQQRVLQKTGLEDRIIETPVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQF3</accession>
    <name>S0DQF3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425713.1">
        <property type="nucleotide sequence ID" value="XM_023571402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQF3"/>
    <dbReference type="STRING" id="1279085.S0DQF3"/>
    <dbReference type="GeneID" id="35398699"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05218"/>
    <dbReference type="HOGENOM" id="CLU_037438_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="51246" checksum="A53F28A4F3456BB2" modified="2013-09-18" version="1">MPSCTMYAPVIQQAASLETLPPEVLLPIVKNLPGLDTLWYLMRASPHVWRLFNDHDVAIVNTILYGPNAILTPEIANAVRAVLLVRSNAHPFRNLYDLQIRFLRSLFPRSTLGDSGSNPDPILVDREMISAAAPPTVVVRSVVATAAHINALAQAFLTSCLQRLRDPGFRPLHLVNPDDRYTSLYRPDPDGKRVRAWDQVFEGEPVKVTDAGQPTWVEEMRAVRALWVLQLIGEIKSQKESLGWSTEDCEKLGRMEAADFAGAVEGNPAMASEEVRSVMDYLGTLEDLAQDTYCRLPRPPMFTRWITATPNLSPQFAKVTHRRKNGSTFTRIEKTEDYSWGRTKENLGYDAPGMSIFKSLSKPRHHPTGGASPIEGVKFNSFRPLGFAFWDAWRMYLLGMHSPVGKHWYGNDTFYFFAWESVLPYDEVASIKAGLRKRWKEELEERREAQRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQJ3</accession>
    <name>S0DQJ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to ketoreductases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_03892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426930.1">
        <property type="nucleotide sequence ID" value="XM_023572886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQJ3"/>
    <dbReference type="STRING" id="1279085.S0DQJ3"/>
    <dbReference type="GeneID" id="35397373"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03892"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT64849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="292" mass="31669" checksum="5B58F4A288E24355" modified="2013-09-18" version="1">MSSPVWFITAASSGFGHDIALHALNLGHTVIATARSTSRVQDLADAGAHTLAFDVTSPLSDLEAIAKEVFSKHGRVDYLINAAGYILDGAVEEVSQQELYDSFNTNVFGIFNTIKAFLPGMREQSIGQNGKRGTIATFGSIGSWRGGATYSVYSMAKTCVSSLAESLRYELEPFSIVATVVEPGYFRTSFLNPGVRAVTKKRMDVYEDESTPTGKTRKALEKTDNNQPGDVKKGTKVIVEVLTGTGVGEGRDVPVRIVLGSDADVYIRSKCEETLELLNEWKDVTVSTDHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQV7</accession>
    <name>S0DQV7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable suppressor of mrs2-1 mutation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_03923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426902.1">
        <property type="nucleotide sequence ID" value="XM_023572850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQV7"/>
    <dbReference type="STRING" id="1279085.S0DQV7"/>
    <dbReference type="GeneID" id="35397404"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03923"/>
    <dbReference type="HOGENOM" id="CLU_008958_5_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="247"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT64821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="552" mass="60759" checksum="4F7F26E452C78EBB" modified="2013-09-18" version="1">MSASSSVARRAVARNPLMGNARALSRGVTPALLGRHVSRNVKVPAIALLIPRSMSTDHHRHDPSSSGPPPGFNAEQAKKPLPKDSAGSVVAKKEDKKLDPNTKDAAVLKPADASAAAKADTEVVATKEGVMEKGDAAQKAKEEKKLTLWEKVKKEAHHYWDGSKLLAAEVKISWRLALKMAAGYELTRRENKQLQRTVQDLGRLVPFSVFIIVPLGEALLPLALKLFPNMLPSTFEGQKSKEAKATLLRSTRKEVSQFLRQTLGESGLPVSQATTQKEEFSNFFRKVRATGETPTAEDVIKVCKVFRDDLTLDNLSRPQLVSMCKYMNLNTFGTDMMLRYQIRHRMRQIKRDDKAISYEGVDSLTVAELQAACAARGIRTHSVSPARMRADLQTWLDLRLKEGVPSTLLVLSNAYMYGQGSGEGYNQVEALIGVMSAIPEELYHEIELEVHSAEGAATNKQRLEVIKEQQDLIEDEAEQDQASQSSGFATPRDTDDIDEKEERLAQAQAEGLGKKQVSEMVEAEMELAKAAESAASLEREINASSGSSKEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR70</accession>
    <name>S0DR70_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427036.1">
        <property type="nucleotide sequence ID" value="XM_023573014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR70"/>
    <dbReference type="GeneID" id="35397257"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03776"/>
    <dbReference type="HOGENOM" id="CLU_160832_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495062" evidence="1">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="111" mass="12235" checksum="7173A0994F9AD796" modified="2013-09-18" version="1">MKYLLTLSLAIPTILATPAPVPDATASREVQACACINAKGETTVNGYCGYIRGRGERVSGGELCYPSDKYSDYMPDYFTADFCKSYYPGYNDRVCKTKTVCPLIGDYWVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRM1</accession>
    <name>S0DRM1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to meiosis-specific protein NDT80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_04794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426108.1">
        <property type="nucleotide sequence ID" value="XM_023571877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRM1"/>
    <dbReference type="STRING" id="1279085.S0DRM1"/>
    <dbReference type="GeneID" id="35398275"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04794"/>
    <dbReference type="HOGENOM" id="CLU_026383_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495082" evidence="4">
        <location>
            <begin position="24"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="NDT80" evidence="5">
        <location>
            <begin position="126"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="126"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT64027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="581" mass="63371" checksum="6284E28A6FD1CA2D" modified="2013-09-18" version="1">MAIQHLCGRVLLPLLLPLPTATAVPYPQEASTSLTIEPSQPSSLLNLFHPPVLSSTAQYPQDGSAFFQSQAAGHHHLYPGIDVRSRLGSNNSSTTGMAHPYPPSHRTPGLPHPGPPISTREQYGPATPGFRRPSEHSVRSPSFATQPRGRHPLSPTTSPNAGFSAPSMASNGYGGRPAQNNIPPLQAVHMLGSLQYNDGAGTPVKVDISGIIDKGFFLSENEWTCYRRNYFSCVCSFSLSPHIPNVTIQYTASGSSQPVPIFGFAMSISAVVSDNEQHNIELVQHTPKRDKGPIMKPEKVRLSNKPPQTSHHHHMGMFSESVVPNRPVYPDNFSNQPGSQQLPTEHTFERIQFKQATQNNGKRRAAQQYYQLVVELWGEVANQSSGDQYVKIATRKSAKMIVRGRSPGHYQNDRRGSQSSGPGGSSGNMGGYTVSGMADFNNPMMGGPSYATGGFDARSSLYGVRHHDIPHESIIPQEDSKAIVTTREYQYYPAPMYEAQSDRIELFNPRGERDHNVVPHMATGMDMSGKIKHDYDGAALPSIFHPPAQINDRPPGPFEGKPTSSGYYPIPSSGINMAMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS52</accession>
    <name>S0DS52_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_04585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426298.1">
        <property type="nucleotide sequence ID" value="XM_023572112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS52"/>
    <dbReference type="STRING" id="1279085.S0DS52"/>
    <dbReference type="GeneID" id="35398066"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04585"/>
    <dbReference type="HOGENOM" id="CLU_655585_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT64217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51739" checksum="A43CE7D1CB1F6257" modified="2013-09-18" version="1">MELSAISRNPLGAPASLLSTLRSYHHIQVDKHFHRREKTSAIPASLEPSMSIPQSICVGIELEFMVALQIPNSDAVTGETRWTCPTTPEAFLGLVMGDYKDIEPSCIHKVCELIASSGVSVSCSLTPSPSSPAQIPGTTILPLTDNSGDIRAWNNKSVSGPVSKTDFWFIVPERHITRDCVSKSGMTPSSKYDWYGTELNSPILTRPEEFSQGLPTLRKCLAAVQGDMVVGLNSGCGLHLHVNEDGSMQLETALRLASLVWLLEDSLLYPLCHPFRSTSPYSARISVDSRIAMERGEPTVYGEGAALVEALGEVMRQLHWRTKVDRGLLGAMKRLWSETSLISLGIALRKFDEGSLHTTTRCALVVSKYDTIEFRYPESTFDVDFIAGWADLVRHLYAVAMRPQVEFHQILCRVYELVTRDQMPGWSAMLGAIGFKGDVSRWQRHINEYGDTLRNLDKQGILSNIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSQ9</accession>
    <name>S0DSQ9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426523.1">
        <property type="nucleotide sequence ID" value="XM_023572391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSQ9"/>
    <dbReference type="STRING" id="1279085.S0DSQ9"/>
    <dbReference type="GeneID" id="35397816"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04335"/>
    <dbReference type="HOGENOM" id="CLU_047590_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="48924" checksum="4E51572430F5D7A3" modified="2013-09-18" version="1">MEKAKQAVSSFLSNDGKHRTTVDEDVKPHVTQEHVMPHQHERVTTALDKEVHQEHHHTTVQPITHKETLPEQHHHNLIPVEHKTFHHGNEQDTRATLDREAAKYRDTTETYSTTHSTEAAPVVTGERIHHHVHEHVQPIINKETVQPHVVHTTIPIHETHHAAPVHHGTSTLPAKTLEEFTQERGGLKERAAQKLTEFEGCPKPYRRELQGEQLEGDKSMHLHGHGDNYGENQAFAGREGHGMGRNTEGLAAGAAAGAGAAAATRKHRHGIGHKDRRGSASSSSSLSSSDEESRGLGKSSKTKNRGLGSSTGTGVGAGAAAAAASAAHSHHQNREGAAAAPSTLEGNRGIGSNTGLQSGSGIPGTAGAGSGVESMGTTGNMSNFGSSNRGIGNTNTAGLNKPHTGDYDQVKTGGLHNDPLNSQHSRGDSGVGMQTGKKPSLLDRLNPMKDADGDGKKGLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSR0</accession>
    <name>S0DSR0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425684.1">
        <property type="nucleotide sequence ID" value="XM_023571368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSR0"/>
    <dbReference type="GeneID" id="35398730"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05249"/>
    <dbReference type="HOGENOM" id="CLU_052707_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484898" evidence="1">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="297" mass="32076" checksum="902F088E4C89491E" modified="2013-09-18" version="1">MRSLTSILLFLSTALAADFQVTWRLEKDTKASSVSATGSDGKVIAEACGSIIHAKYPIDFSDVDDTGSGNFTVGDASYLVHSLPEWSGGPACSRIFNPQYTLVQCSNFTWDSTDVVKDKADACFSDSTTDGELQSLQRRSLSHEMHSPGAELEKRQTFCSGWFTRTRLVGDGDPHQNYYHKQLSENINCANAASCSVGQTDSTSYTIGWTANASPASWISGGFSVSESWTTGNSYTCNGDTVQEYTKNTCTEGSGGTPYVMYSPNENNRGGGYYCVIGTCRSKGDGYWDYNGRAGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUC6</accession>
    <name>S0DUC6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_03041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428127.1">
        <property type="nucleotide sequence ID" value="XM_023574843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUC6"/>
    <dbReference type="STRING" id="1279085.S0DUC6"/>
    <dbReference type="GeneID" id="35396523"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03041"/>
    <dbReference type="HOGENOM" id="CLU_003442_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10812">
        <property type="entry name" value="GH38N_AMII_ScAms1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="553"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT66046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1080" mass="122675" checksum="AC8D726250F6649C" modified="2013-09-18" version="1">MGGGSENKGDGSSYPLFAERPVGVPKTSILKGRIEPFYKSGQYYKVNLQANMYNGRYSGKPHVQLSVWDAPDLTRPTFEEATSHEFKETHTGTSFGPSWSTHWFKVVLRIPDEAKDEELIELHWDANNEGTIWTEDGVPIQGLTGSGERIEWIIPDSFRDGEEHTIYIEMACNGMFGNAPNGTTTIAPPDPNRRFNLSKADIVAINVPARKLHLDMWEIGDAARELPENSAEQNHALSVAMKIINTFEVNNQESILKCREIAREILGPDVDSHKVYERGKEPVVFGIGHCHIDSCWLWPWAETKRKVVRSWMNQCDLMDRYPESNFACSQAQQYKWLKTYYPAAYKRVKQKVKEGQFHPIGGSWVEHDTNLPSGESLVRQFFYGQRFFEAEFGSRCRTFWLPDTFGYSSQLPQLCRLAGMDRFLTQKLSWNNINNFPHTTFMWVSPDGSQVICHMPPSETYTANADFGDLKRSIANHKTMRVDSSSLLVFGKGDGGGGPTWQHFEKLRRCAGISNTIGGIPKIKMGLTVDDYFDRLSRKASEFPTWYGELYFELHRGTYTTQANNKYYNRKAEVMLRDIEQLATFASIKNESYKYPTKDLDDMWEAVLLCQFHDCLPGSSIEMCYDDSDKVYAEVFETGKRLLKDLYESLNISSEFSTCLNESVAINTLPWHRKELVELSDTEVGVACGDGQLLNLRTFKTQEEKPAVTVMEQSTDVYVLQNEQLRVVVESGVITSLYDVVNDREVIEKGGEANKFVIFDDIPLYWQAWDVEVYHLDARRKVEYGKTKIFEQKPHRVTLVTDVKISENSYIKSYTTLSAALKGQPSRVDVRADVNWHEDSKFLKVEFPVNVVNTEASYETAFSITKRPTHYNTSWDMAKFEVCCHKFADLSENNYGVSILNDSKYGFATAGKTMRLSLLRAPKAPDANADMGRHSIRWAILPHKGCLSSTTVKAAYAFNNPLKPVTASKAVLESVSSAPIKLVNIDESDSLVLDTIKRGQDDEDVSRDDGLRINKGQSIVLRVYESLGGRSRGVIETSFDVKRVTKTNILEDELEEIQKEDGKFPITLRPFEVATFKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUD5</accession>
    <name>S0DUD5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_03213</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428285.1">
        <property type="nucleotide sequence ID" value="XM_023575035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUD5"/>
    <dbReference type="STRING" id="1279085.S0DUD5"/>
    <dbReference type="GeneID" id="35396695"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03213"/>
    <dbReference type="HOGENOM" id="CLU_141397_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT66204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="85" mass="9450" checksum="361D75A6C111F3B6" modified="2013-09-18" version="1">MDSTQVKAAVIKQVQQEANLVNARTLIEKLQETCFEKCVPKPGTSLSSSETTCMTSCMEKYMAAWNMVNAAYIARLRQESASLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUT4</accession>
    <name>S0DUT4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_03367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428425.1">
        <property type="nucleotide sequence ID" value="XM_023575207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUT4"/>
    <dbReference type="STRING" id="1279085.S0DUT4"/>
    <dbReference type="GeneID" id="35396849"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03367"/>
    <dbReference type="HOGENOM" id="CLU_090389_14_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484553" evidence="3">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="15"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT66344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="161" mass="17272" checksum="5493BDD45285B2EE" modified="2013-09-18" version="1">METIYIVFGLLALFMIAQAVFADRSPIPETSGKVYKISAPSELDSVFASNTHVVVDFYADWCPPCRAIAPVFSNLADAHASEGQLAFAKVNTDHVKDVAAKYGISAMPTFVFFENGIAKGVQVEGVNSRAVAFTKDGRVDRIRGADRGALEAVVKALASEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVT1</accession>
    <name>S0DVT1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_03609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428651.1">
        <property type="nucleotide sequence ID" value="XM_023575476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVT1"/>
    <dbReference type="STRING" id="1279085.S0DVT1"/>
    <dbReference type="GeneID" id="35397091"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03609"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485331" evidence="6">
        <location>
            <begin position="17"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="307"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT66570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="421" mass="46557" checksum="A45AB3FCD35FE9A0" modified="2013-09-18" version="1">MHIVIIGAGPAGLAAALALSQTTIQGSPTQITILELRPKVETLGGTILLTPLALRYLDDLGVGSRLRKLGIPVRGVDVVALRTGRTLGQMLPGTDALRVIRHHLVQCMSDVVAELPQDRVTLRYGATVTGIQQVGDQGEDEGAVRVDVQFDAGKSEDSISCDILLGCDGIHSFVRTTVVDCERKKTYSGRAIAYGYVNCDSTGDIGLTTSDGKLRLRDSTMIQGQHGSFLMTYFEPSRGKVYALAIMPMAENQDAREGWKALGEDKVAIKRDIVDRFKEGGIKGLEPIINESDWYFYPVYMLPVEGRWSKGRVFLLGDAAHAMPPQGESTGIAIEDSVLFAHVLSEGISRGIPYVMEAYETLRRDDITKLHSETIFRWNTGSSSSWLWSIMMEFATWVYLLLANYRQEDYFKRDVRSFKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWC6</accession>
    <name>S0DWC6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock factor binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427778.1">
        <property type="nucleotide sequence ID" value="XM_023574421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWC6"/>
    <dbReference type="STRING" id="1279085.S0DWC6"/>
    <dbReference type="GeneID" id="35396145"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02663"/>
    <dbReference type="HOGENOM" id="CLU_168441_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000006">
        <property type="entry name" value="Heat shock factor binding 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8603" checksum="B6640A03DB45D5F4" modified="2013-09-18" version="1">MASNEPQPDPTANSKTENPSDDARADVTAAVEELLNSLSNKFAGVSSEIFAKMDEMSRRLDNLEAALQESKAKDGGSTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWR5</accession>
    <name>S0DWR5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_13116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429022.1">
        <property type="nucleotide sequence ID" value="XM_023575762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWR5"/>
    <dbReference type="STRING" id="1279085.S0DWR5"/>
    <dbReference type="GeneID" id="35406570"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13116"/>
    <dbReference type="HOGENOM" id="CLU_019706_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495278" evidence="2">
        <location>
            <begin position="21"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="94"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="4">
        <location>
            <begin position="422"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT66941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="574" mass="62538" checksum="1A5FE99DFF610F4A" modified="2013-09-18" version="1">MKIPVQPLPLLLLLTGDVLAAKNYHCPPIGPVLPAPTNPSSHQNVKIAIEAITETIKAYSSLLHSTAVSVGVTSIYEDKPLLDFHHTPENLDPRGASKIDADSVYRIGSISKAYTTLAALKLQGVGMHDPVTKYVPELRKLNKQQSENNAITTVDWDKVSLQALASHMGGMPADLVTDLTSFRNWTDLGLPAAHDVLGCAGLVGIPPCDVQDFWDNFGKRPPTFAPWGNPVYSNVAFFVMSLVIERVSGESYEEFVQKNVLDVAGMNSTTYSKSDDSVGAIGPDDTFWNSSIGILSPAGSFYSSTKDLLSFGSSILKHEFLDLAETNEWLKPVTFTSGRGEFIGAPWEIVRSNKLTSDERVVTVYTKGGDIGTYHSIFAMIPDYGIVISVLVGGPESAGGLPLVFFSMITKVLVPALEAAGKDQAKKAFARTYINEDTNSTLVLDVDDDGPGLSITKWIVRGTDVSTHWLHYLSVLNPNVPKISLSGRLYPTDLKAGNKTAWRAMFRIGTATQIGMQEGLLFWEDASCMSWAMVDRAAYEFLGLDEMLFESEDGKAGKVELVGFKTTLRRSEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWZ6</accession>
    <name>S0DWZ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Related to PAN1-actin-cytoskeleton assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FFUJ_02918</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428013.1">
        <property type="nucleotide sequence ID" value="XM_023574705.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DWZ6"/>
    <dbReference type="GeneID" id="35396400"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02918"/>
    <dbReference type="HOGENOM" id="CLU_001963_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000349">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF173">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="18">
        <location>
            <begin position="187"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="18">
        <location>
            <begin position="455"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="488"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="287"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="840"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="885"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1148"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="288"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="840"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="885"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="975"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1036"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1085"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1124"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1155"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1171"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1197"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1250"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1279"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1337"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCT65932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1412" mass="152947" checksum="D264FD1D20F61182" modified="2013-09-18" version="1">MYSNSNAFLGGNSQRPGGQQQQYGGGSFGNLGAGQQPGQPSPFAPQPTGFGQAPLQQQYTGFPMQGQGLQPQQPLQQQFTGFPGQQQQQSQPQQQSFQTGAPAMPSIPPQFQQQQQQQPTSFSASPQQASGPSNPPPAPMKPQATGFTEMAASFQTGGTAKPRGRRQEKSQPNKIPNIRLSFITAQDQAKFETLFKSAVGETGMTMSGEKARDLLMRSRLDGDSLSHIWTLADTTRAGQLYFPEFALAMYLCNLKLTGKQLPPALPENIKNEVSSMVDIISFSVADESAPGASSSSAPDIRTNTATPPTIQQPQPQPQASNAQLLQAQMTGFPGQQTGFGQQQGLQNQQTGFPGMANNPQATGYSGPRPPMPPMPTGFGQSLAPGPAGGMAAPLNAQPTGRPGQWGLVNAPSTGLPNIDALQAQMMPQQGREAGNFTTQGLRGNAVIPWAITKEEKTRYDSLFKAWDGLGKGYIGGDQAIEIFGQSGLEKPDLERVWTLADHGNKGRLDLDEFAVAMHLIYRKLNGYPLPNNLPPELVPPSTRNFSQSIGTLKSMLHDESEFRTKSGAALLPQKTGVSYMKNRSFRGAPAGAVAGRKDATVFKNEDEQFGYRSSARRRVGNNSPRPESPASVASNDDLTLDQLKKKIKEKEVLLDAMDFADEKNHEEDDILDRRDRREAEELYRRIRRIQEDIDSHPDAALASGDSDAERRALKRQLQSLTDKVPELASQVRRTEKAIMDARLELFRIKDAKAHPGSGAPIVGTGPGGTVTESDRLKARAKAMMQQRTAALTGKKVDVGTEDLDAPKRLEEESIKVKNEKESNERMVRDVEESVRDFAHGIEDSLKEGGRDNTSEHEKRRWEDALGVEDEVRDFIFDLQRESRSVRIRAQDKRPARASARTEESRPERVASPRVESPVSTSRTATPPAGGSYSSYKTPEERAAFIKQQAEQRMAERLAALGIKAPTKSGETAAQRIERERAERAAKLRQAEEEDARREADRQARLAEEQGIPPPTPEQSKAEAKRPPPPPTRHRGKPEADQEAAKRVEEDAAAKRAEEARLAHEHEQQQRETQQMEEDAKEQEDDLAKEREASEARLKALEEQVRQGKLRKEEEKKRKKAAMAEAKEKEAKLAARRAEIEAARQRELELQRQLEAMEDDDSSSSDEDAGPQQITPQASTPTRSDSQVASQELDKKASPPPAAEAVSSPPPPPPPAVVTSPPSETESKNPFFRMMSQSTEGTPAAAPPAPSATNPFHRMTQNQEGKAPSGPVSRRRADTDDWGSDNDDKDDDSDDERPGGGSAAQLASMLFGTMAPPRPLSAAGRESATASPVAANAAPPPPPPMPSVGAPPPPPPPMGGAPPPPPPPGDAPAPASGGGRPAGFLSEIQLGKALKKTTTKDSSAAAVAGRVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXC4</accession>
    <name>S0DXC4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_04108</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427194.1">
        <property type="nucleotide sequence ID" value="XM_023572646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXC4"/>
    <dbReference type="STRING" id="1279085.S0DXC4"/>
    <dbReference type="GeneID" id="35397589"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04108"/>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT65113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="323" mass="34771" checksum="D39A66B96FDD8A5B" modified="2013-09-18" version="1">MLDQMANEIKLISGSSHPEISAKVASRLGIDIANTMSLNYSNRETSVSIGESVRDEDVFILQSTAPGDVNDGLMELLIMIHACRTASARRITAVIPSFPYARQDKKDKSRAPISAKLIANMLQVSGCNHVITMDLHASQIQGFFNVPVDNLYAEPSVLRWIRENLSVDNCVIVSPDAGGAKRATSLADRLNTGFALIHKERPRPNVVGRMVLVGDVSDKVAILVDDMADTCGTLAKAAATVNEHGAREVYAIVTHGILSGKAIDTINNSCLSGLVVTNTVPLGDKIERCPKLKVIDVSGTLAEAIRRTHNGESVSYLFNNVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXG3</accession>
    <name>S0DXG3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_03057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428143.1">
        <property type="nucleotide sequence ID" value="XM_023574860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXG3"/>
    <dbReference type="STRING" id="1279085.S0DXG3"/>
    <dbReference type="GeneID" id="35396539"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03057"/>
    <dbReference type="HOGENOM" id="CLU_004390_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="794"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="898"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="951"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT66062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1140" mass="130493" checksum="B51B693A6EAEEB45" modified="2013-09-18" version="1">MELADGSTDIVHPEVRAHINSLVSALGGISADDDGGYQLGDDALEVLRDLKRWIRFYDEKTNRMDVARCIHEANLIEGDLLPILSTWPENATDSKFKSRIALACFELMVPLTWPMARDRERMTVNHHRHMPVLELAQVGYKRAVINYDGARVLHTAVRVALPSMAIPIGDRTQRDHGIIKLVLFFLRNIAMIEPPPDVKYEGDESQISRSATIDAFSYQDIFLVLLTLASNMGEDFRTEDTSVMEIIYHLVKQVDIEKLFMNEQQLSKAKAGELADMMSKESSMLKAYNRKGPTRHNRFGTMIWVKRDDGKMSSLSGQDALADASMRNQKMDNSKTFRPPRRARKGDKDEKDLGLPTKLNSRAYDQLRLFVEDFLDSGFNPLFQHVRKTIDREAPHVMQYHRRQFCYLVAWFLEAERMRRKAGKQSTKNPSEDISSFNLVAGVLNQEMFITLNKALHESLEMKDWHELTAVMRCFTQILLTVQEMSESGNEDNEEIAENVLSRLFYEEATHDAIATIIRTYKDQSFNYLDAATELVHHFLRILEGYSKQNIDMQVRSRKRTRRKKKAAQDAAGIENDNDENDGSDNDAASAERTTKERKFDFHRFATRFTPQSVVDTFVAFTKYYRDLTDSQLKRAHRYFYRVAFKAEASVMLFRVDIIHLFYNMIKGPAALDKSSRVFKEWEELVKQILRKCFKKLEQRPELLVEMLFSKGSSTAFFLEYGFERQTVTAASKAKPAAELVFKNTEELDRQIAIVVGAMLDKNQVNHVAWIKKILGDAESERKAFMAAEEAMASVEPVQDDAEEQPTESGPKAPPIFFVRPDDKDRRNAMFKNSHMRLLMKLVGLQLLGPASDETPESAWIIPSDVSADVLTDAIHYINQAEFSPPTFDEGVLAEHQLKRKSAPRKKADFDDDEEGELDDPMFGPLGPTVRKPIDEEDDPKKSPRKRRPRKELTEEERQKKREERRRKEQEKVKRLRSEKYVRPEDDETDSEYDELFYAREREAEAKASAIRHVAERLIVSKKPTRKRGIAATESASSSEEHQGGDDSDSGDDFILRAMNTTLEEENGGQPEGVLPDGSDGEGCKRRRISVEKTQPDEDEEMGGVNRNGDGNEDEDEAPVVTRRPRVRSGFVVDSDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY62</accession>
    <name>S0DY62_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to HOL1 protein (Member of major facilitator superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428428.1">
        <property type="nucleotide sequence ID" value="XM_023575210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY62"/>
    <dbReference type="STRING" id="1279085.S0DY62"/>
    <dbReference type="GeneID" id="35396852"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03370"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="559" mass="61216" checksum="C5B38AA6DBB54E51" modified="2013-09-18" version="1">MDEKSDFPDLATIASADHIEDEKKAHTAHDGGHIEGNALLVNRQGEIRKIPVPSSDPNDPLNFKPWEKYGLVFCCCWFSVMGLSVASGLGAILNVFFEMYIPKGFNSDQVVLLITLPTLFIGLGNYIILPLSLAYGRRPIFLISVVVLLAASIAAATQNSYYGHLVSRILQGIATGASESLLPLMLTEVTFLHERAFIFGLYWMVQNAISSSLNLASSYVNADLGWRWYYWVFTITVGVGLIIAFLLGFETQFTRPAASLDGQLVITDEFGVTKVIPDSEAQAYLEEMSSSGLTAPNAGNPAQVIERKAYVERLRPWSKPSSQPLRVILLSWKYMLASFSSPGILYAVLTSSIALGCGVGMSLTYNQVLMQYYHWEAKDIGLINIGGVVGAVLGMLYCTFLANPFVLWMARRNRGIHQPEHHLITMAPPAVVGVGMLLLYGFTAGGGATWWGPYLGWTVFQYSFTAVIIISTTFASEAAPKHPGPALVTVVGTKNIISFGVTYGLTPMIEEHGYKWAFSVLAGLFGGIFMLGIPVCIWNPKWRAYVAEREARKGTTTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYD8</accession>
    <name>S0DYD8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429640.1">
        <property type="nucleotide sequence ID" value="XM_023576435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYD8"/>
    <dbReference type="GeneID" id="35407173"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13719"/>
    <dbReference type="HOGENOM" id="CLU_169137_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="79" mass="8997" checksum="4932385AB393AAD0" modified="2013-09-18" version="1">MPISKKDRRNKEHKRADAAGTRAPVKPNGLPVKAPKPTSICQNCRKEIVNTNKLQLEVHASTHDAKLWPKEKCWPNDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYV6</accession>
    <name>S0DYV6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable FAD carrier protein FLX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_02603</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427724.1">
        <property type="nucleotide sequence ID" value="XM_023574354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYV6"/>
    <dbReference type="STRING" id="1279085.S0DYV6"/>
    <dbReference type="GeneID" id="35396085"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02603"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="112"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="219"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT65643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="307" mass="33713" checksum="024ED033DDC5FC28" modified="2013-09-18" version="1">MPDSDHAGLSPATIESIAGLSAGTVATLTVHPLDVVKTRMQIYRSAAPDAVRPTTVSILRALTSTPHPVASLYRGLTPNLVGNASSWASFFFFKSRFERALATWQGRLGGRPSGGDYFIASALAGAATTTLTNPIWVLKVRMVSSDRGSHGAYPSMLAGARSILQTEGIRGFYRGLGISLIGVSHGAVQFAVYEPAKKWYHARRRERHGIEREHMTTEATVGLSSLSKFVAGAVTYPYQVLRSRLQNYQADERFGRGIRGVVVRIWTEDGLRGFYRGMVPGVVRVMPATWVTFLVYENVKYYLPQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ18</accession>
    <name>S0DZ18_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429746.1">
        <property type="nucleotide sequence ID" value="XM_023576599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ18"/>
    <dbReference type="STRING" id="1279085.S0DZ18"/>
    <dbReference type="GeneID" id="35408022"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14642"/>
    <dbReference type="HOGENOM" id="CLU_010194_38_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="354" mass="40180" checksum="0D11A108828F88DC" modified="2013-09-18" version="1">MNASFYQSLPTLYFELLADNLAQLATIDYFHYLRAFKKEIITFLALVGTARFVTWVLCASFSFYTYCLHRSELHRYNHVSPDGSAAWALVTGASGGIGYEIVREFARKGFNVVLHGRVEQDLLAAMMRMHEEFPDRNFKILVADPTVLGTKEFWYRKSYGDWKLERKLDLEAIKNELSKLNLTVLVNCANAEAKHTDLGRILDENEKSIWKHINSDALYPIQLFRALLPTLIGNAPSLIINVTSLSDKGIPLKISASASRSFLSRMTESSALEMKLDGYDVEALCVRVSRCMGQTDSTLARAIIARVGSRRSVVVGHWYQFLYKGLIDLLPGRLWDWCIIHYIRGMTDIKCKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZT8</accession>
    <name>S0DZT8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430000.1">
        <property type="nucleotide sequence ID" value="XM_023576842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZT8"/>
    <dbReference type="GeneID" id="35408230"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14852"/>
    <dbReference type="HOGENOM" id="CLU_829091_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="323" mass="35710" checksum="A5AFB3461C2B2785" modified="2013-09-18" version="1">MGREEMQDRLKELETEKSVLEWALEASLHEKGVDTDEEDSKFDSLSTYTMADYPASNPQVDEPLVHVYPTEPISDTESAISLHSTEKSVVCSEASTMARIKFTTTMPVQQVVQSDPASYRYDGTGMSEDGWEDEETVRGSTVGIGKGKEASEDANATDPNSPLIITNPHPSLSISTEFLQKAILDSRKPGSPFLRSFIHREPVDGKSGEYTDWKWIPFLVFGAAAELVSTNIAKGDIEIICMKDTQFTNLIQNNENMFEDPGSLAAKSALHGELKPAFNGPESWGFRVLVWRLQSSEKTVYMDREGHPIPGKAGALPWDEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZW0</accession>
    <name>S0DZW0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to ascus development protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_06909</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430224.1">
        <property type="nucleotide sequence ID" value="XM_023577102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZW0"/>
    <dbReference type="GeneID" id="35400386"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06909"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT68144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="497" mass="54272" checksum="09749BD2AD450CAF" modified="2013-09-18" version="1">MKSDAWLSKPFLTSIFLGIGGFLYGFDSGIITPSLALSSFLTYFGKPDPPLRGAIVSMYQAGAWLGSASVGITSDKLGRRKAIAFGCIWGVIGGAVMAGAAHVAMLIIGRLLVGFAVGTITGVSPVFGAEIAKTHERAKVTAVNQMMTAWGFFVALWIGVAEGKWHNANQWRLGFAIQSIPALILGVGVLFLSESPRWLCLKGRHDEAEKAFRAYHYDGTNDDWCRTEFTVIQVNISEELQAQGKLSWAQLAKTPAFRKRLFVGTFVWAAAMLSGISFVQYYQTAIYATLQFSEDRQLLVSGLYGSVGPVACFLSLFFVDKIGRKKILVISSSLLSLCYLIITILAAEFPAIPGMPTNAAAQRGLIACIFAVSANYSALLGPMTWIIPPEVFTTELRAKANAIVQVVHYSISLIITQCSPIALAAVGWKYYILFVLTNALCAIIFFFVYPETRGKSLEEIDEIFGDVKIVHEEDVRFSEKTGVEAIETRDQRIMQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0G0</accession>
    <name>S0E0G0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_06884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430200.1">
        <property type="nucleotide sequence ID" value="XM_023577075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0G0"/>
    <dbReference type="STRING" id="1279085.S0E0G0"/>
    <dbReference type="GeneID" id="35400361"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06884"/>
    <dbReference type="HOGENOM" id="CLU_006462_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF222">
        <property type="entry name" value="MALTASE MALT (AFU_ORTHOLOGUE AFUA_8G07070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="26"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT68120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="606" mass="70055" checksum="E77AEEABC1DDB50F" modified="2013-09-18" version="1">MGSIVWDDEHQYIGKQPWWKAASFYQVYPASFKDSNNDGWGDLPGLISKLDYLSDLGIDVVWVSPIFESPQKDMGYDVSDYQKIYEPYGSVEDVDILVKECHARGLKIILDLVVNHTSIEHEWFKESRSSKDNPKRDWYIWKPARYDENGVRHPPTNWRGYFACSTWTWDEGTQEYYLHLYAPDQPDLNWDNDECREAIYENTMRFWLDRGVDGFRIDTVNKYSKRRDFVDAPITDPASPHQPAPEMWCNGPRIHEFIHEMYEKVLGPYNAVSVGELSNTPNPSQVIPYVSAAAKELDMVFEFSMIRLGNGNGFGDKYIYQPFPLSKLKAFVYKWQSFIEGTDAWATAFCENHDNGRAVDRFGDASTPEWWLKSAKTLAIWQTTLTGTLFLYQGQEIGMTNMPRSWGIEEYKDIESSNFYAEAVASGDEKRVRDTMHGLQIMARDHSRIPFQWDDSPNAGFADALAKPWMRVHDDYRDINVAKQVKDPNSILSFYKAMLRLRKQYQDIFVFGSFKLLDPEDESLFSYIKESSVPVKGRRLEKRKAVVVLNMSREDKLGPDVPTVLGCAHEDVRLMAYTRETASGLKGGRPMLAGWESRVYVNFELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1U3</accession>
    <name>S0E1U3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428709.1">
        <property type="nucleotide sequence ID" value="XM_023575543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1U3"/>
    <dbReference type="GeneID" id="35397151"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03670"/>
    <dbReference type="HOGENOM" id="CLU_109886_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495428" evidence="1">
        <location>
            <begin position="19"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="173" mass="18862" checksum="BD060AE388404747" modified="2013-09-18" version="1">MVKIQLLYSLAFVASTLAAPSGVLSSLFSSLDKRACTNPSNMLQNPGFESKSIKPWVYAPYYPKLTSQKLVTPGYKSDKALQIAGIATTQNEYGYSTLKQNFTNCKFGKYQLSWSMYLPKGAAQGLDPRIPGMNIWVYDPAGQGQVGTLAFGPNSFNSSLGYPVKQGTHKANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E284</accession>
    <name>S0E284_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431029.1">
        <property type="nucleotide sequence ID" value="XM_023578066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E284"/>
    <dbReference type="STRING" id="1279085.S0E284"/>
    <dbReference type="GeneID" id="35401253"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07776"/>
    <dbReference type="HOGENOM" id="CLU_037787_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="359" mass="39288" checksum="40728AD2E6E7BB21" modified="2013-09-18" version="1">MLEVHCSGTPYEIGHRHGTAAKDRVVGSIAFYKDLFQESCAMNWETVRQEAQQYIQPLRKLSPRYVEELQGLADGAGFELVDIVALNVRTEITFGLYTRVPSAPIQTDGCTSAAYRQPNGEVLLAQNWDWQPEQAPNLFVCHISQPGTDIPDISMVTEGGVIGKIGINSSGVGTCLNAIRARGVDNTKLPIHLALRTALESHSAHEAADKLYELGTAGSGHILVSDPSEAIGLECTSIGIKEINFDGNGTLIHTNHLLLDHPGVDEPGWIPDSTDRIKRIAQLLDERLASLTIDHSSFFDFFKDEQGYPTAINRDQFSPGNGKATLFTINMDLAKRKAIVTMGRPTNWTERIELSPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E344</accession>
    <name>S0E344_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_07849</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431364.1">
        <property type="nucleotide sequence ID" value="XM_023578148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E344"/>
    <dbReference type="STRING" id="1279085.S0E344"/>
    <dbReference type="GeneID" id="35401326"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07849"/>
    <dbReference type="HOGENOM" id="CLU_009902_5_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="60"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="213"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT69284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="565" mass="61641" checksum="2AAA823C1F7B8B10" modified="2013-09-18" version="1">MLRPFTQYLPTRARASCSRVLGQASKLSLARKSMATVHVKGIEKDPTELDRVTTLPNGLRVASEALPGSFAGVGVYIEGGSRFENDSLRGVSHIMDRLAFKSTSKRSADDMLEQVEALGGNIQCASSRESMMYQAATFNNAVPPTIELLAETIRDPQITEEEVAEQIETARYEIREIWSKPELILPELVHTAAFKDNTLGNPLLCPEERLGVIDRNTVLAYRDLFYRPERMVVAYAGVEHGEAVRLTEKFFGDMKKGSERVQEITGSETSESELSDSEASSSSASSSPQSSSGLLSRFFKHTPSASQNLQNLPSQNDITKPSKYTGGFLSLPAQPANLSGLPTFTHIHLAFEGLPVASDDIYALATLQTLLGGGGSFSAGGPGKGMYSRLYTNVLNQHGWVESCMAFNHSYTDSGLFGISASCLPGRTANMLDVMCQELRALTLTTGFSRLQETEVARAKNQLRSSLLMNLESRMVELEDLGRSIQVHGRKIPVKDMCRRIENLTVDDLRRVAKMVVGGKVKNPGGGSGAPTVVLQEAQAYGVSSHSMSWDQIQDRIDSWKLGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3M9</accession>
    <name>S0E3M9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431375.1">
        <property type="nucleotide sequence ID" value="XM_023578163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3M9"/>
    <dbReference type="STRING" id="1279085.S0E3M9"/>
    <dbReference type="GeneID" id="35401339"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07862"/>
    <dbReference type="HOGENOM" id="CLU_012066_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="97"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="603" mass="69396" checksum="93E78F7949AA127D" modified="2013-09-18" version="1">MPTPQEIQLPGFGLPISHAGAHFPAVLGTEDGDGEGDWRASTLTIREVCMIKVIEDLTNKPEWWIKVNDDEITAKWKKEAMEMPWGEYRVYGDFTQAMADACIRELRKKADIYQKTGLIPVMDYASAAIKSDNLVPKDLRDALISAVSPLENVPEKHKDWHPGSDGKVLDIVHPSLWPLVYGRSLILPDKRINLEEALPHCGKGVVIPVDDSDVSKRHPSAFSKRFQWLPCDVDLTGEHPRIDSYINNVHPVKHAELYPVIEKFVEKSLPAWDVIYRWHKDFEVQRVFTNNVRPDCKVPEICGDEWCSAQNRPLDDDEEPRREDEDYEEDYEESDRNKRDEEWFRETHVPELPDPKTELEELVKIDPRDVKTSGFFGNASRVQVIVKLANIHLTPEKPTYDGGSWHVEGQLNEHICATALYYYDCDNITDSRLDFRTVANREDQTLDLSYEQGDFDSIERVFAIDPGADTLQNIGSVLTRQDRMLFFPNVYQHHVSPFELVDKSRPGHRKILALFLVDPQIPIISTANVPPQQRDWWAEGLLRNDRFNNLPPELTRMVVDNLDFPIDLEDAKKIRGELMAERTGMQGTLNTNLKNLEWNFCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3P1</accession>
    <name>S0E3P1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431529.1">
        <property type="nucleotide sequence ID" value="XM_023578535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3P1"/>
    <dbReference type="STRING" id="1279085.S0E3P1"/>
    <dbReference type="GeneID" id="35398815"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05336"/>
    <dbReference type="HOGENOM" id="CLU_598636_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="504" mass="56107" checksum="CD3033DAACA0BF27" modified="2013-09-18" version="1">MHIESNSDANLQDLFCQLARYFSANEDKISAAEASKCFLCLSLLDSVALIRLFFLLCPSFRSVLSHQGGVSAVFPTTPSRPSDDNDTHRQPDPPEPPPGLRDHQNSHENNSSSIPGFEELQDPVSTNDNGLPTAHSSPAAENGGAQVSGEIDDIYTLESGFLEPNTFYQQQTLNELQHPISNTLTVNPSDTMAFPDNDNAIGKTRLATCSELRFTATLRQLLETCKTDKSLFIRKIEESKASLPNGQGWRAAIAIEQENADMRDLLSIYHRFECYNIYRHVAEAGFHTGEHWIRDKRLELAKRLCDDFPERFHDTKAANKCLNWVDQGWLGILIALPPEIPRSAYTSRCAKEHMSAAAARFVALGINDLVKDLKLSELGDYIARRLEEMTTGKRLEPSQRLQQSSTPRLVSSLGTPTLLQSEQTESSPGAITICEDTAMLDHASFLSPSMFVDDDLSNYQLSSSAYLDLSMDDQLPAFSFPFDELYQHLNNTEVQMVTCSETTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3W2</accession>
    <name>S0E3W2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable mitochondrial ATP synthase subunit f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431516.1">
        <property type="nucleotide sequence ID" value="XM_023578093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3W2"/>
    <dbReference type="SMR" id="S0E3W2"/>
    <dbReference type="STRING" id="1279085.S0E3W2"/>
    <dbReference type="GeneID" id="35401278"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07801"/>
    <dbReference type="HOGENOM" id="CLU_152700_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="101" mass="11319" checksum="D09CDBA8E2777E6A" modified="2013-09-18" version="1">MSFVTRRALSTLIPPKVASPKAIGAAPDAIRMQRVVSFYEKLPRGSAPEVKAKGLLGRYQAKHFGKNPTGKPIIHLIVFLVSIGYVQNYYFHLRHHKNNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E554</accession>
    <name>S0E554_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to monocarboxylate transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_07655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430917.1">
        <property type="nucleotide sequence ID" value="XM_023577932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E554"/>
    <dbReference type="GeneID" id="35401132"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07655"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF230">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="58"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT68837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="456" mass="48751" checksum="2782F4F6D997F5E2" modified="2013-09-18" version="1">MADSTQQEQSVQRNSSQENTNWAAFGLDPITATVSNINPDAEAQPEADSRQDVEKTVSAWICVLGSFLALIPTFGFMNSLGTVQTYLSMNQLHDYSEGEVGWISGLFLFLSLILNVQVGPMVDVHGPNIIGPVGAVLYVAMFLLMAECRNYWHFMLCLGVFGSIGAAMTMVVAIAIVGKLFVRKRGLAMGITLAGSSIGAVIFPIILRSTYPNLGWQWSMRIMAFISAGLLLPAILCFTTFNKIYKSSTNGQPSPKSSTLNLTAFQSPAFCFVTAGIFMFEFVIFSISGLLPSISTRVGFTAENGYTLLSIVGAASTFGRVIPGIIGDKYGHFNVLLATLVFTIIFMGALLVPFGTKSATALYAWSAIWGFGSGSFLSITPVCMGKTCEAKDYGMMNFVTAFALLIALPTSGAMLENMGPQALAGLFTGMTAVGGACYFAARALLIGKWLSPTTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>S0E567</accession>
    <name>S0E567_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_05830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431986.1">
        <property type="nucleotide sequence ID" value="XM_023579087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E567"/>
    <dbReference type="STRING" id="1279085.S0E567"/>
    <dbReference type="GeneID" id="35399309"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05830"/>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="865"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="895"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="935"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="87"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="257"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT69906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113326" checksum="6599DE87DB4855C1" modified="2013-09-18" version="1">MSKLFRRRKNNNDDLESNAGRRASRASRGGRAASIVDDSLGEYPALDHYISNYREDRRRPADDRDGKVKKKHWWQFGSGVDAQEEPPAKKGTPDAWLETDLTAGLASDEVERRRQVTGWNELVSEKENMFAKFLGFFTGPILYVMEVAALLAVGLGDWVDFGVIVGILMLNAFVGFYQEKQAADVVASLKGDIAMRCTVIRDSNEKEILARELVPGDILIVQEGGTVAADARLICDYTRPEDFELYKRLRAEDKLDRSDEEDEFAEGADKEQDHDTSTEHDAHQHSHEQEPHDYRSRPLAAIDQSAITGESLAVEKYLGDMVYYTTGCKRGKAFALVQTTAKESFVGRTADLVQGAKDQGHFKAIMNNIGTSLLVLVMFWILIAWIGGFFHHIGMTEPGSQNLLHYALVLLIIGVPVGLPVVTTTTLAVGAAYLAKQKAIVQKLTAIESLAGVDILCSDKTGTLTANKLSIRDPWMAEGQDVNWMMAVAALASSHNLRTLDPIDKVTILTLKRYPEAREILKQGWVTESFTPFDPVSKRITAVCRLGNDKFWCVKGAPKAVLKLASGSEDESRIYKEKAQDFARRGFRSLGVAYKKNDGPWIILGLLSMFDPPREDTAQTIIEAGHLGVPVKMLTGDAIAIAKETCKMLSLGTKVYNSERLIHGGLSGSVQHDFVERADGFAEVFPEHKYTVVEMLQQRGHLTAMTGDGVNDAPSLKKADCGIAVEGASEAAQAAADIVFLAPGLSTIVLAIKTARQIFQRMKAYIQYRIALCLHLEIYLTLSMIIINETIRVDLIVFLALFADLATVAVAYDNAHWEPRPVEWQLPKIWVMSVILGILLALATWTLRGTLFLPNGGIVQNFGSVQEILFLEVALTENWLIFVTRGGKTWPSWQLVFAILGVDVLATLFCLFGWMSGRGEISHPESNFKQSSNGWVDIVTVVIIWLYSFGVTVVIAIVYFVLNKLSWLDNLGRKDRKKKDTKLENILGHLQKLAIEHEVDEKTGKSRFMLAEKAADEDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5A9</accession>
    <name>S0E5A9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xanthan lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429879.1">
        <property type="nucleotide sequence ID" value="XM_023576815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5A9"/>
    <dbReference type="GeneID" id="35408206"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14828"/>
    <dbReference type="HOGENOM" id="CLU_025277_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498:SF1">
        <property type="entry name" value="COB--COM HETERODISULFIDE REDUCTASE IRON-SULFUR SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12831">
        <property type="entry name" value="FAD_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485600" description="Xanthan lyase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64741" checksum="E11EF278366FE465" modified="2013-09-18" version="1">MASVHIVCLYILASFTVGVISATSHESDVIIYGNTVAALAAAIQTVRMNRTATLVFPTSRIGGLTTSGLGWTDSKDGNTIGGIAREFYGKVYEYYDNDDAWTRETRDDYLAKHIEAQPGPAIGDKVQWTFEPKVAEEILEKWIKDEGIPVFRNESILRTSSGVKKDGTVIKSFQTRSGSTFSGKMFIDAGYEGDLMETAGISYRVGREDKQEFDESAAGIHFNEPRRLAAIDPYNDPDDPDSGLLPGVGRVITKFAALESRGKKDHRLQAFNYRLSLTREDDNKVEFFKPDGYNESDYKILIRYIKTGYLGPFFTTQLMPNLKTDTNAAGQISTDLIGGSYNKTSNYAEYSYEEREAAAKRHKIWAQGLLWTLANHKDVPDFIRKNTSAWGYAKDEWTDNGNWPYEIYIREARRMDGVYTMTQADIQHPKPYDNDTVVAVGYYTLDVHQVERVVINDRIHDEGLIHVPNPGPFSVPYGSIVPKREDATNFVNPVTMSATHIALSAIRMEPVYMIMGQSAGAAAVLAIEDNVAVQDVDRKKLKGRLKDHAQVLESFSIMLKPSQRLLLVGFISCIFYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5E9</accession>
    <name>S0E5E9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432004.1">
        <property type="nucleotide sequence ID" value="XM_023579107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5E9"/>
    <dbReference type="GeneID" id="35399327"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05849"/>
    <dbReference type="HOGENOM" id="CLU_078844_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="73"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="177" mass="19375" checksum="1F0AC404D65F9A49" modified="2013-09-18" version="1">MTEPLSKVDSAVQGLSSSPPAKDDKKTRRQSSAAAPGVYNVNDLEAEGIELELAPETQKTGWKINTSPNTVEDPAILKLHLSKPPVKRIDLHFPLGKEVTARNLKGVTIKDALDAIHKAYKKRADDELDKPYLAGFEWDKEESWTQLVVHLQAQPTSTTLGGPAGGGKKKKNKKQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5I7</accession>
    <name>S0E5I7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to condensin complex component cnd3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_07901</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCT68972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431052.1">
        <property type="nucleotide sequence ID" value="XM_023578205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5I7"/>
    <dbReference type="STRING" id="1279085.S0E5I7"/>
    <dbReference type="GeneID" id="35401378"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07901"/>
    <dbReference type="HOGENOM" id="CLU_004446_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000363">
        <property type="entry name" value="Nuclear condensin complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="615"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="958"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="971"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="998"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT68972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113985" checksum="0B01C8519E18B0B4" modified="2013-09-18" version="1">MPARTTARSSRTSATRSSAASRVSPVAEPVDTPDNALRTKVCAVFRDAQRTTATHRKLVVNLRKIQESCAYEPTNPDQSHADDFDEDAFNHEFIRCVSKIMPIKKSESVGEKSIKFTGLFLQHASAKDNELLGEIDQDASVMPETPSTRLTSQLLEAILPLLTAKDKVVRFRSTQLISHIINSLDAIDDDLFQKLRHGLLKRIRDKEAMVRSQAVLGLGRLAGNQTEGCTNSDDSDDDDTGLLEKLLEVLQNDPNADVRRSLLVNLPILPETLSVLLERARDQDAATRRAVYSRLLPALGDFRHLSVKMREKLLRWGIRDRDENVRKAASRLFRERWIEDCAGVPPQEDGVPAEPAPPNFDGLLELLERIDVINTGVENGVALEAMKGFWEGRPDYRETVEFNDNFWETLSAESVFMARSFNDFCRLEGDGKYLNLLEEKLPEVTKLAFFLERYLHVLTAAVKRVAEADDEDEEEDTVEQEFIVEQLLQIALTLDYSDEVGRRKMFTLLRQAISIPDLPDEVTKLAVETLQSICSPDAAGEREFISIVLESVADVHDTIVDDLPADDAEDSFHSARSEVSGQSTPTKGSKRGGTPELSEEEAREKAVREIVVNMKCLHIVQCMLTHVASNLQDNTDLVAMLNNLVVPAVRSHEAPVRERGLVCLGLCALQDRSLAEENLSLFMHFFTKGHTALQITALHILTDILNVHGAQLLSSTPGLLKIYVKAVKGGGKSPEVQAAATVAASKLLLGRVVSEEEACQDLLKSLVVAYFDPSSASNQTVRQALNYFLPVFCFSREENQNLMRSIALDAIHALFNVRESLEDDDVDVDEDMVSMTTIGACLVDWTDPRKCYRSTNLLESDKKAVNGDVHLDFAMDILEKLQGNITKEEKKLIGTLLGKLHISPGSSEEKLREAYNEVSIAVEEGLLSDATSRSALFKLHVSLGKIVNALDEQQPAYRRTSRSTSVILDHQSPEEEKTVMEEPSIKEEDEESDGTVVPKEEKDERESLVDDLLSDGDDVEMTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5P2</accession>
    <name>S0E5P2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to Drosophila ANK protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432094.1">
        <property type="nucleotide sequence ID" value="XM_023579218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5P2"/>
    <dbReference type="STRING" id="1279085.S0E5P2"/>
    <dbReference type="GeneID" id="35399427"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05949"/>
    <dbReference type="HOGENOM" id="CLU_097653_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="208" mass="23489" checksum="E8EFBB58299FE5A7" modified="2013-09-18" version="1">MAGDEEHDGATVQEILIEACRRNNLDLLNDCLEDKSDAEISKLLNETTTVMGNHLYHEAASRGNYEIIDHLLDQPEFECDPINRSEGDTPLHSAIRWINSEPPAQRPFGNALVEMMLEAGSSTRVKNKARLTPYQLVDPTNTELREIIQKHEYANQNAGDFINVNNSAGHSGAVLDVPDDSDDDAEFSGSDEEERAEWERRRKEKQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5T2</accession>
    <name>S0E5T2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432225.1">
        <property type="nucleotide sequence ID" value="XM_023579379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5T2"/>
    <dbReference type="STRING" id="1279085.S0E5T2"/>
    <dbReference type="GeneID" id="35399570"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06093"/>
    <dbReference type="HOGENOM" id="CLU_015980_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="570"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="698" mass="75810" checksum="FC6AD5F273216026" modified="2013-09-18" version="1">MSHNQQPMSIEAMLDMERKEVLALLENRPRPEPSMPGAMRSASPYATPRSPVRSMLDVDDQPTPSSPRQTVRSMLDTSSPPPPKYRSMLDTDTPLAGPSRPSGTSTTPNSPVMTKATLAPSSVGHTRSFSDAASNPVDFGPRAAAARNDPTAGYQFSDIITRNSGQQLPKRNTQGGRKPSANALSEALRNADLSGLQIPGEGDGRRSWFGGSSSSQKSKSPHNRLGSRSRSPAPVTQVLAPGKAMLDDGRIVDISNAYRRLSDANLAYAGGSLSQLPRRNREDAKSGRMIKDYLSPDGEHLGSSEEDEAYSSDDEDRGRKKAPRSLNPDAIGGSADDPNKERRKSMSLLAAAEEERTTVAAKQPKYRSLLDEPEIKITTPLGENTRLNKGGGVHPKTAYDQMSTVASANDSDEEADMDDIKRAQKLSCSMSGIISTPESHRAIRMIYRGDYNKIVQQAEEEHHRLRKYLVASDLSDESTHALEWAIGTVLRDGDTLLCIYCVDEETGIGGVDNSVPDDPKAMREQAAAINTVASSRSAAPSMSAVPDFVRNSIRGDSSKNNTPNTSPAPSSRGERGRAEEERRRAVKEITDKVLRLLRKTTLQVRVIVEVLHCKNPKHLITEVIDHVNPTLVVIGSRGRSALKGVILGSFSNYLVTKSSVPVMVARKRLRKQGKYRGVKPVNNLSNPAARSLANAKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E749</accession>
    <name>S0E749_GIBF5</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432808.1">
        <property type="nucleotide sequence ID" value="XM_023578759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E749"/>
    <dbReference type="GeneID" id="35399017"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05538"/>
    <dbReference type="HOGENOM" id="CLU_1525231_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="181" mass="19585" checksum="2BFCA56504B9121C" modified="2013-09-18" version="1">MTLNTKLKRKPLPSSPPKPSSPVSESLPSSSPPKARSANAIRSSSKNCPVCKAILVNRNGSLARHVERHAKLAKIEAMNIDLNLPPKEAPDFDVKLAQNMWQSVPARRRATGGVFLDGPLAGKGFFEGMPNVFLPNGRVKPKLAWIKKDLESRVGRGPLRALKNANANAGSLLDSEDYMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7D4</accession>
    <name>S0E7D4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430483.1">
        <property type="nucleotide sequence ID" value="XM_023577407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7D4"/>
    <dbReference type="GeneID" id="35400660"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07183"/>
    <dbReference type="HOGENOM" id="CLU_164903_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="86" mass="9685" checksum="4577B086B6F27AEA" modified="2013-09-18" version="1">MSPIVVRSAARAVQRRQFSLLTAMRNAGRAMESHPFERLPITQQPAKPDYAKMFKRVGSQALFFFPGFAVILGWPLAAQYAFDGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E905</accession>
    <name>S0E905_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to vesicular amine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_08578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433438.1">
        <property type="nucleotide sequence ID" value="XM_023580704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E905"/>
    <dbReference type="STRING" id="1279085.S0E905"/>
    <dbReference type="GeneID" id="35402054"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08578"/>
    <dbReference type="HOGENOM" id="CLU_001265_51_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT71359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="477" mass="50959" checksum="0E105C944D3D1296" modified="2013-09-18" version="1">MGLLRWPHKDKPPVLLKVRSSAGLIVTTCSFAIFTDIFLYGVIVPILPFSLQDRIGISTNRVQYWVSIALAVFGAALLAGSPVWGYLADRIHNRRMPMLIGLIVLCGATVFLCVGRTLALFMIGRALQGISAALTWTVGLALVVDTVDKEHIGKAMGWISTACSLGILVAPLLGGLVYGKGGYYSVFAMCFGLLAVDIALRLLIIEVKDAKRWLDRAEPKAVADPEHVVTEGPNMEKNKDNIAQQTDGQTEDVSDPSRSPIKTLVKLLGQPRFLAALWGTFVQALINTALESTLPLLTHEIFGWDSIGAGLIFLPVILPSFLGPVVGMVGDRYGPKWLASFGFLFATPFVVCLRFVDEDTIQDKILLCGLLAGVGITTACIFGPLMAEITWSVQGEDGTEGAGQIAQAYGLYNMAYSGGSLVGPIMGGMVKDSAGWATVGWSLGIVVFASAIPTVLYTGGPLKVKLRGWGRQNSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9H3</accession>
    <name>S0E9H3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to DUF453 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433399.1">
        <property type="nucleotide sequence ID" value="XM_023580658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9H3"/>
    <dbReference type="STRING" id="1279085.S0E9H3"/>
    <dbReference type="GeneID" id="35402095"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08619"/>
    <dbReference type="HOGENOM" id="CLU_026443_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="374" mass="39395" checksum="EA8EC354C9B04770" modified="2013-09-18" version="1">MTTSTPAPSFPAWFARGGTSNGLVIHRRDLPPESQWHKILPSAMGSPDPYGRQLNGMGSGISSTSKIVILGPPSREDVDVDFTFVQVGIRDGSLDMAGNCGNMSSLVGPAAWDSGLLSAQAKTVEQDENGLQWATVRFLNTNTNKVMSSKFRVEGETLKYTHQGDYVMDGVPGTGSKIIMSFIDPAGAKTGKALPTGNPVDVLQLQDGTKIKASLVDVGNPGVFVSTESLGLADHLSLTPAIVESTPELKEKLGEIRRAGAVLMGLDPNTESVPKIVLLFPSSGSPDVDIRCLALSMGQAHKAVPLTLALCLGAASQLKGTLASDLIGGQSKETICIGHPSGKVDIGTVIRDGKIESAQLLRTARILMKGDLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAA4</accession>
    <name>S0EAA4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432766.1">
        <property type="nucleotide sequence ID" value="XM_023580030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAA4"/>
    <dbReference type="STRING" id="1279085.S0EAA4"/>
    <dbReference type="GeneID" id="35400154"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06677"/>
    <dbReference type="HOGENOM" id="CLU_103814_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485033" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="213" mass="23651" checksum="362676628AE024C3" modified="2013-09-18" version="1">MKFQPSLVLFAAAALCNAKVFDRQALSYAPIPYDIYQPPTDSLETTLLDLIKSRDDLSELLKLVEETPGFAQAFSTSADWQYTFIAPSNEAFNNTGEYYKSFASTPKGRWWSGQMLQHHYIPNSRLYTGNFTTQKTRIQLGSYLYASAQIKDGDLVLNNVATIVEPDIPVTSGIVHISDRILAPDAMVYEADIGTTKQGFIPGSCSNPNLPYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAD2</accession>
    <name>S0EAD2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_06527</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432796.1">
        <property type="nucleotide sequence ID" value="XM_023579862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAD2"/>
    <dbReference type="STRING" id="1279085.S0EAD2"/>
    <dbReference type="GeneID" id="35400004"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06527"/>
    <dbReference type="HOGENOM" id="CLU_002360_9_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF346">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="824"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="862"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="941"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="974"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1034"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT70717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116178" checksum="829222DC15603BB5" modified="2013-09-18" version="1">MSGHLDPKALLDPRQRSISEVGTISSAGDTTVVPSINTAEIPQYLDAGNEKRFPHDPNNPFNHSPEVLNQLLDPKSLDVLKGLGGLPGLARSLNVDLKAGLSVDELNNQNCPRIKVFGRNQLPAKKPKSIWRLAWITFQEAVLIMLTVAGTISLALGLYETFGVSHQPGDPTPVDWVEGVAILGAVVIVVVVASHNDWQKEKAFVKLNTKKDDREVKVIRSGKSMLVNVADVVVGDVMNLEPGDLIPADGIFIDGHNVKCDESTVTGESDALKKTPGAKCFVDDPMRTKEPDPFIISGSRVLEGMGTFIVTSVGVNSSFGKIMMSVRTDIESTPLQKKLEGLAVAIAKLGGGASLLMFFILLFRFCASLPGDDRPAEEKASTFVDLLVVAIAIIAVAVPEGLPLAVTLALAFATTRLLKENNLVRVLRACETMGNATCICSDKTGTLTTNKMTVTAGRFGSSSFTSDIPTWATTLPPETRKLITQSVAVNSTAFEGTNEGDAAFIGSKTETALLQLAKDHLGMQSLSEARANEQIVLIEPFNSVKKYMLAVIKVQAGYRVLIKGASEIMVSFCSTEVNPSTGAVEALDRKAADDAIMAFARKSLRTIGLVYKDFEEMPDLENLGDLTLLGIVGIQDPVREGVPQAVQNARRAGVVTRMVTGDNLVTARAIATECGIFTDGIVMEGPDFRKLSEEELDKVIPRLQVLARSSPDDKRVLVTRLKVLGETVAVTGDGTNDAPALKAADIGFSMGISGTEVAKEASEIILMDDNFASIITALKWGRAVNDAVQKFLQFQITVNITAVLLSFVTSMYDDKMEPILKAVQLLWINLIMDTMAALALATDPPTDSILDRPPQPKSAPLITLNMWKMIIGQSIFQVVVVLVLYFAGDSILGYNTSIAAEKLQLDTIIFNMFVWMQIFNELNCRRLDNKFNVFVGIHRNLFFILINAIMIGLQIGIIFIGGRVFDIDTDGLNGVQWAISILIAAFSLPWGVLVRIFPDEWFAKVVYFFAPPFVWAYKWMGRGWARFMRLFRKSKKADDEEDSSSLEGRESKEKSSVVGPMIVEPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAF1</accession>
    <name>S0EAF1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_08305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433684.1">
        <property type="nucleotide sequence ID" value="XM_023581010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAF1"/>
    <dbReference type="STRING" id="1279085.S0EAF1"/>
    <dbReference type="GeneID" id="35401781"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08305"/>
    <dbReference type="HOGENOM" id="CLU_027686_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="8">
        <location>
            <begin position="112"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT71605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="460" mass="48576" checksum="A456E62262D49D1B" modified="2013-09-18" version="1">MEGRKVPRAPELSAESPSSSSAGFKTYSAAGTASASADRISLVSGHLSSSSYTAASPAQASVPSQARRLSTTTTTMSSQPEHATLLIPGPIEFDDEVLKSMGHYSESHVGPGFVNTFGETLTLTRKLFQSTDPSAQPYVISGSGTLGWDIVAANLVEAGENALVLSTGYFGDGFADCLHAYGANVTKLDGEVGGRPQLPEIEKALSEKKYKILTVTHVDTSTGVLSELKNLAATVRRVSPETLVIVDGVCSVACEEIAFDEWGLDGVVTASQKAIGVPAGLSISFFSGRAVAAALENRKTPIPAYFASLKNWTPIMKNYEAKKPSYFATPSPQLIHALHTGLTQIFTKPLSERFQGHIEVSNKVKKAVTDLGLKVVATKPEDQAHAMTAIYLPDGIGAADVLPKLAAKGVVFAGGIHKAIAPKYIRFGHMGVSALDPSRNHIEKALSALKDSLFEVGYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAM2</accession>
    <name>S0EAM2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434007.1">
        <property type="nucleotide sequence ID" value="XM_023581289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAM2"/>
    <dbReference type="STRING" id="1279085.S0EAM2"/>
    <dbReference type="GeneID" id="35407532"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14078"/>
    <dbReference type="HOGENOM" id="CLU_001305_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="71514" checksum="42ADE75E63E01D4B" modified="2013-09-18" version="1">MENLDQDILEATKNMPTEPEKNDAGKESLEKLADLLITRYQQTGNTDDLRKSLRHKMLLFRSLHIPNEASLWYVVIIDESIGSDVPCRYEETNDPEDLRAAITICWQVFFEEPSNAEHEALRVRLPFILRTITLHLYEKSGNLGDIEMAASYSRQVLPFVPNDIEDRANPLDEFARTLFKKYQVQENPDILTVGIPLSKDAISATPEGHPELPARVANLGAWLLRRYERNGDTNDLQEAIEKTELASSLLDKENFNQLRFLTNLGIMLFRQLELTWDENDPEQAEIMASRAYIGRSLHVNSIAHPLLGIEAARDAIRIFKFHGRLEEANSLTQKAFQLLPMACHPNIARQDQQHAIQQMSRFAAEACSLSLLVGKTQEALLSIEFSCEIILYHLIKYRNKLPLLEQQSKRSAERFDQLRSAAAQPVDTVNQVTIQDRIVPEAQDFAHDYEFELALIRNLPNFQNFLTLPNLHDLVKGVTDGSIVIVNITPLSSDAIIILQSGKGIRSLNLPKATCVGNLFLDKYSKAFGHIRKSQVLEEQHIESDKDLYDEQFLSWLWTACVDPIVKEIAESQSSSLAPRVWWIGTGIASGFPFHAAGKSEGSTLDNVISSYIVSITSLIEPKGSMTCSDKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAV5</accession>
    <name>S0EAV5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433869.1">
        <property type="nucleotide sequence ID" value="XM_023581232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAV5"/>
    <dbReference type="STRING" id="1279085.S0EAV5"/>
    <dbReference type="GeneID" id="35401582"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08105"/>
    <dbReference type="HOGENOM" id="CLU_029538_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013437498" description="Serine aminopeptidase S33 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="165"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="457" mass="49969" checksum="E7D6439DB49F5EB0" modified="2013-09-18" version="1">MLSKLLSIILISSALAASQTHLPYANEPNRCDATCQIAYRQVLAMEAERWVNQDITTDSFYSTPSNVSKYSTGDILKWEKIPSEQAYRRWTVPAGISLIRFFYMSEDIKGKPLAATGIVLIPYSNPQGNKPFRTVVWTHGTAGGTRQCSPSNHRALLYGWSAPFALALAGYVVIAPDYAGQGSEAQGLMYEAGILHAADASLSVQAVRKALGSKITKEWVVMGHSEGGMSCWRTNEREAKPEATGGLIGAVCASPGLVPSKIIAEMIRRAGDGPAGDFLSSLMLQSVSRIYPSIKVKDYASDILLARMPLADQGCFYTSAALYSNLTVSQLYKNTSWIQHPDFIKWETIYNGAGPHKLAAPLLVIQGTEDTLVYADTSEEAFDETCKEFASSTTAEFRLYPGLGHGAVLPASQQYFLSWIEDRFNKVSLKKGCKKLTLTPETDNFSPVNDEWVAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB01</accession>
    <name>S0EB01_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434164.1">
        <property type="nucleotide sequence ID" value="XM_023581470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB01"/>
    <dbReference type="GeneID" id="35407370"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13916"/>
    <dbReference type="HOGENOM" id="CLU_1129088_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="246" mass="26693" checksum="53C2C8B0A22FA5A5" modified="2013-09-18" version="1">MSEDTSNQDQSMVDPSETPPSRAETEVVIADEAAVNGASEVLPSAGEIVEQESSASTPDAEPQSIPEALGLELVGELRLIGIMSPLGSAMAIYVDNHCGDGVYNVMANSNIAVRAVIAQGHFDIMQQVLQAVFPVERFGLLEFTVPFRSVGPELREVPLPAGFSRAYLGLRPAGTVEPRFEIRGRDEGPPRLVRQVERAWAEWLAVNQVPHGDEASWGLVAWPELPYCANGMDLEIVQELEEELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBC0</accession>
    <name>S0EBC0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to monocarboxylate transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_13761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434309.1">
        <property type="nucleotide sequence ID" value="XM_023581642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBC0"/>
    <dbReference type="GeneID" id="35407215"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13761"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="71"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT72231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="468" mass="50224" checksum="8CEA3D3017A5318F" modified="2013-09-18" version="1">MTFNEHNAEDSCLKNQHEKQAIPKTNPDVPRGDAVPVPDNAGLETGGVAYPGEASTDDSEANLEFPEGGLQAWLVVFGSFCGMFSIYGLINTSAVFESYFSENQLRDYSSSQIGWIFSLYLFLVFLVGIQVGPVFDKYGPRLIVASGGILIATSLFILSVCEEFYQILLSYSVVGGLGGALLNSPCYASIAHWFDQKRGLATGVAMTAGSIGGIIFPIFLQKLLPSVGFAWTTRILGFIILGLTVPATLFMRSRLPRSNKVSSVWPDFSIFKDLKFTFSACGIFFMEWGLFVPLTYIVSYAGRHSGDANSSYTLISILNAGSLLGRFLPGLLADKIGRFNVILLTLGLCIISVFALWLPAGDSKAMIIAFAVVFGFASGSNLGLTPVCVGQLCDPRDYGRFISTAFMVASFGTLSSLPIAGAILEAGGKGDTGWTALIVFDGLSYVLALACFLAARVMAVGWDVKSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBK2</accession>
    <name>S0EBK2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to cercosporin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_08815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433216.1">
        <property type="nucleotide sequence ID" value="XM_023580441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBK2"/>
    <dbReference type="STRING" id="1279085.S0EBK2"/>
    <dbReference type="GeneID" id="35402291"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08815"/>
    <dbReference type="HOGENOM" id="CLU_006524_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT71137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="634" mass="72772" checksum="F70A48562980A427" modified="2013-09-18" version="1">MDECLISQDQDRQDVAQKTRACTNCARLKMKCQWPSSGSGRVEKTCSRCLRMKLDCQVPEITQRRKRGKSTRVAQLEKKIDGIVSLLSANQRKGLSPLTPESPQEVQSHAPCQPYAKENPFTTNHDMINQIPDDSVRFSTDVELFPGFRVSQQEASERLDVYRRDYVPHFPFVPVPSSMCASELYVESRVMFWTILAVVSPLNDKAQMEFKAWFRRYLAEHLVVRQEKSNDILQAMLIYLAWNDFHFYGELQVTNIIQMAIGLVIDLRLDKHAGQFLGGPKTLLGDAWTSMSKHPLKMKVHQTAAEKRAVLGVYHITNLLSPYFRKSTIFHWSTHLASCCENLAEAREFESDIYLVSLVRMQHLADRGFSVIPSTDPFDPTPPTFHAVTAMALDTVHRELENYFKVQPEIVKQIPGFRAHYNSILVRLFEPILTMKPSSLVSSDTSLTEPFLRTEYLWKCLEAIQNTLENHVTLPPEKISILPVTVSCVLAFVTVTASRLIMAENSTDWDVKAARRRLQFQDILQRLSDQFAQADEEAQRLNRRRRVMEDGSSVFLKSSFKVRWIRQWYLSKIPEDEQLLLVPQPQTTVENLSVLQSNPDWAANLQFDDEFWAELLNGFDMEAFDKSLTTVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBN0</accession>
    <name>S0EBN0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434382.1">
        <property type="nucleotide sequence ID" value="XM_023581729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBN0"/>
    <dbReference type="STRING" id="1279085.S0EBN0"/>
    <dbReference type="GeneID" id="35405612"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12156"/>
    <dbReference type="HOGENOM" id="CLU_063282_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="253" mass="27242" checksum="73BE086479503123" modified="2013-09-18" version="1">MAEYSSLKVPELKKLLAEKGLPQTGNKADLIARLQENDRTSETVEKPAENKEDEISYSDDEAPAAPAAAAPVAASEPVTEVPSTEAAPAEADKAEETTAEKPAETAEAPAEPEKSYAIGLQSTAADDEAKKRAERAKRFGIEEDEDAKKRADRAKRFGLDEKELATTLDSALPERSRKRGRDRTTEGEGNRPGKRQSLDRRNGGGGRRRGRGGRDGGRDGGARKDKTSTRSGILDDPTEKAKAEKRAARFAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC04</accession>
    <name>S0EC04_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_08607</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433411.1">
        <property type="nucleotide sequence ID" value="XM_023580671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC04"/>
    <dbReference type="STRING" id="1279085.S0EC04"/>
    <dbReference type="GeneID" id="35402083"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08607"/>
    <dbReference type="HOGENOM" id="CLU_030047_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT71332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="496" mass="55483" checksum="1F7AA9E2AB2D0258" modified="2013-09-18" version="1">MRERVTFIHNDYTLDPEQLDNQEAGLLGPQIESVRQDKLTIPFDELPSELTDILQEYEALHIRWASPVRSETLDPFTSRISPGLHVYVTPESPNSCNPTKLCGWLQRFGPLACSKPEAFTEFKQPATSTAPDFSFHQTLEDLHSFITISSREFCPDLDTVCNARLRSLLTATSLDLSFDKSAKALVASVLWPLRPQTVAVPASTERRVEVGIFVNDRSQPNMKENELGVAGVLSVLGDKKKPSPTIFTFPARHRRDESVFTSRFLTPTGLHPTLQLSFSSNKPPSDEGECVPYAFLTLPKAIFADRYQLGDDLFLASKNLTALRYTTLPVDLEAPAYTTETWGSSILLELAPPTSEEGQPWNVEIPLHLRYLKPSVTDQAEADVPYPAVFWACSLGEETLENPFDRLHIGYDNLFPRDTAFWHVNPQPEGGSRLMHRVTVPVLKLEGIDTIRSGTAIAVLLGFAWVLWKLVGVMLKSEEPVLKKTAPKRSKQNKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECA0</accession>
    <name>S0ECA0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable ribosomal protein S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433526.1">
        <property type="nucleotide sequence ID" value="XM_023580818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECA0"/>
    <dbReference type="SMR" id="S0ECA0"/>
    <dbReference type="STRING" id="1279085.S0ECA0"/>
    <dbReference type="GeneID" id="35401953"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08477"/>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="145" mass="15744" checksum="DC1C34DDF77BD2A7" modified="2013-09-18" version="1">MAGGKPRGLNAARKLRTNRKDQKWADLAYKKRALGTAYKSSPFGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECN6</accession>
    <name>S0ECN6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to transcription factor 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433641.1">
        <property type="nucleotide sequence ID" value="XM_023580958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECN6"/>
    <dbReference type="STRING" id="1279085.S0ECN6"/>
    <dbReference type="GeneID" id="35401827"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08351"/>
    <dbReference type="HOGENOM" id="CLU_008321_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="700" mass="79309" checksum="BBAAA8EFBA00A844" modified="2013-09-18" version="1">MSTRQLRKLQKQRDLEEIQILEEKSSGESDKENEPVASKPRVSLFAALGGDDDDEEQDEDEQQQQQSEEAVTETKQPLTSVKRKKKKNKKKKAKAKAAAPEEDEDEIDKAMRELNIKASTPANTSASENTEAQTRRINELLSINPYHLKANNEMRSLFGRDVIESAAAEEEQERNRRPMQREVDLETFLRGPPGAPKLPEISLRRNVFIQGREHWPKQSAGGLTMKEVAKAEDGSFTEYTYVHEQSYDALQAFFFTCVQIGDPQRMIVLLKEAPYHVSTLLQVSSIAKQDQNQALAAELCERALFTFGRVTTNAFRQNIEQGKARLDFRRPENRQFWLAGYHYLKSLMRKGTNRTALEWAKLMYSLDPSDPYAMRHFIHWLAIRAHESQWLIDFVEELEKTTDNRDSIYLRQTLVLAHLQLGNTARATEELEKGMRRVPWLYCGLFQELNLDTPPSIWGINADSNSRSFWVKLYIHQAKDIWNNAQAIPLLEKTAKSLEKVDTSVLPSSDSPPDQGVTRLVYLEGQTSLMGLAPREYLEMQPNYEFDPLPPPEEENIFTGEGTKMPFVKQRGQQSAVETRLNNMFERLAAAGRGGAPGAAPLGPDGEDDEEDAHLAAVQALDDEELMRDLEEHEQGDAPGLVQRIMHVLGIIAGPNAEDHDMPDEADDDQEHEHEPGQDEDDDQERGPNSGLPGAWPGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED69</accession>
    <name>S0ED69_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434618.1">
        <property type="nucleotide sequence ID" value="XM_023582022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0ED69"/>
    <dbReference type="GeneID" id="35405874"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12418"/>
    <dbReference type="HOGENOM" id="CLU_002457_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485790" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="829"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="896"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="977"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1731" mass="165878" checksum="4A9DECAF499E3A33" modified="2013-09-18" version="1">MTHSLIWRALAAITLTVSASAYPHQTYPNIVPRAGCPIPDICAWGSCTNTTIGLDPRNCGKFGNSCEPSEICVAGQCLPLDLGTSDCPTDCKPGQLCNNGECVSIEIAVDPLHCGGESCNSSSLCINQRCQKLDIGSDPASCGPSNTKCDAGSWCLYDTCIPFILGTNVQACDERTSCSLGTSCEDGYCRQIFLSTDINNCGEDSKACTAGQVCVSGQCQSLDDEDADQNCDTPCEPGSWCMSGECIPISISTDTSQCGSSTEPCGKGQVCVSGHCISNLVHRESIPKTACSPSTRLGGFLFGPGGSSDQNNNGGGREGSPNDATSGQGGDQQGGDSTSNSNGSGSSPDETSGGGGQTQGGQGGQGGYPGGFPGSRPGSNSGSGNNQGGPDNFGAGRPGPGEDGNGFPSSACEPECASNFICVSGECLSVSDPLSCGPSANPNRLFHRQNAVCPPGYACIDDRCVRVDGPISCGGSICPANYACIQEACVPLGDPTDCGGERCASDEICLGDTCVSNPALASCFGVVCPPGQVCQNGDCVAAGSPGANGNPQGNGGRPGGDGGSSGGGSGNGGSNGGNGGSNSGGNGGSGNGGSGNGGSGGGSNGGNNGGSNGGGNGGSPGNGSGNGGTGNGGSGNGGTGGGSNGGSPGGNGGSPGGGSGNGPDSGNPEGNGGRPGPDIGGDGSSTGNGGGDGGATVTSPPAGTATRSGAGNFPDSTASSADASDDAPIVNPGPGTTGTDGLSASTTSIRGGPDGNGGSTTSGDGGGDSPTETDAATSDAGPIIGPGSDSTDLSGASTKVTGGAEGGGGSEITLSGTALPTDTSGESPTDGGSSAAGSAGTDTTGIVNPGAPTTDGSGISASETGATGATDSSGATDSVGATDSAGSTGTNVDGQTETASTTRAATATPTETTPCSTDDDCLLNVALCVFNGLNICTCVDGVCTQQPGGPEGSGVTGSDLGTSTAGNGEPTDSAGSTITDDTGETATTTGDPAATSAVSCSADDDCLANAVFCSDGLLNLCICVDGICILDPALASTTDTNNPGQTTTVQDATTTDAEAAATSSAVACTTDADCLADLGLCVDGLINLCICVDAICIVDPALATTSGIDNGQTTTDAAATTTEEAAAATSSAVACTSDDDCLVDVGLCVDGLLNLCVCVDAVCILDPALATTTADATGTATQPAPTETTAATCSTADDCAVNVDLCIIGGLNLCVCLNGVCVGDPDAQETTTANPTATNTGPGATSTAVACSTADDCAVDADLCLDGLINLCVCLNAVCVNPGGGGDQTTTETGAGGGPTTAPVACTTADDCVADADLCLDGLLNLCVCLNAVCVNPGGGNDQTTTETGAGGEPTTAPVACTTADDCVADADLCLDGLLNLCVCLNAVCIVANPGGDPTETTDLPPENTRTPCSTNGDCTANAALCLDGLLNICVCLEGLCIVNPVVNPTETTAPAPTETATTSCNTADDCTANAGLCLDGLLNLCLCVNAVCVPSPGGGGNNGDPCTDDSDCTAAGAICLDSGVCGPNPGNTPTSCTTADDCTANAALCLDGLLNLCVCLNAVCVQAGGGGGGNTGDACTGNADCTTAGDVCTNGVCTAAGGGGTDACVDANDCLLSVNPLCALGLCVCVDAVCTTSPDVDECTSNAGCSAGATCQNGVCVDNTDCTGAADCLANLDICVLPGVCACVNGVCGLVGNGPTPECTAAADCRTLPRCRLGLCLCVAGQCILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDM2</accession>
    <name>S0EDM2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-haloalkanoic acid dehalogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432572.1">
        <property type="nucleotide sequence ID" value="XM_023579800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDM2"/>
    <dbReference type="STRING" id="1279085.S0EDM2"/>
    <dbReference type="GeneID" id="35399948"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06471"/>
    <dbReference type="HOGENOM" id="CLU_114181_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24978" checksum="7CF090ABDDF99283" modified="2013-09-18" version="1">MNAPTDENWQPKAIVFDLLTGLLNSWDIWDASTPSKTHQDGGRWRQRYLEITFGTGSYKPYEDLVRQAAAEVGLPPSAPEALLKNWSSIKAWEEVPSVLQALKAQGYKLGVITNCSKHSGYIAIRGVEEQASVGFETPFTFDAAVTAEESGFYKPVKEAYDAILPNLGVGAEDILFVAGSAGDVEGATNAGMKVVWHNKIGLAKKGNAIPLRQSRTLDDTLKGYLEKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDZ9</accession>
    <name>S0EDZ9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434125.1">
        <property type="nucleotide sequence ID" value="XM_023581423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDZ9"/>
    <dbReference type="STRING" id="1279085.S0EDZ9"/>
    <dbReference type="GeneID" id="35407411"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13957"/>
    <dbReference type="HOGENOM" id="CLU_023231_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485153" description="Beta-xylosidase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="46728" checksum="0E12A7F0436EF074" modified="2013-09-18" version="1">MCHATFTTLVLAIVTNVAAQVQGTATVDLSKSHGPAQALGSGFIYGWPDNGTHVDTSIPDYLVTDIKFNANRGGGAQIPSLGWARGGYEGYLGRFNSTLSNYRTTRKYNADFILLPHDLWGADGGQGSNSPFPGDNGNWTEMELFWNQLVSDLKAHNMLDGLVIDVWNEPDIDIFWDRSWPQFLEYYNRATKLLRKALPGTLLSGPAMAHSPILTDDKWHTWLQSVSGNKTVPDRFSWHQIGAWEREPDTTIPDFTTLRAQYGVPEKPVDVNDGSDLHNWMGNLIYSSTGTSEGTYYPNGEWQVYKYYAAMTGQRFLTKASSDSKFDVFATKEGHKIKILAGTRTVQEKYSIEVSGLGAVELPKKGTVKVRTYRFDWAGPNGKVDGPIDLGEKKYTYSADTLTLSVNPPTNATAFAYEFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE09</accession>
    <name>S0EE09_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to alcohol dehydrogenase homolog Bli-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434978.1">
        <property type="nucleotide sequence ID" value="XM_023582444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EE09"/>
    <dbReference type="STRING" id="1279085.S0EE09"/>
    <dbReference type="GeneID" id="35406252"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12796"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="306" mass="33324" checksum="196F7B43031CBCB0" modified="2013-09-18" version="1">MGPVKFSPDTDIPSQNGKVILITGGNSGLGLETARQLLKHEPSRIFLACRSKAKFDQAVNDLRQGGANTDAISFLALDLASLASIKSAAAEFQTSSTRLDILINNAGIMMTPEGRTEEGYEIQIGTNHMGHAFLTHLLLPILEETTKINSDVRIVFLSSMGESMSPKNPYQFDQFNTTMPSYSSTSRYAISKLANVHYTAALAERYPNIKVISVHPGVVQTNLAAPLINHSLILGTLTRLALSFIAVDASKGALNQLWAATDPKAESGVFYHPVGVTGKGSKLSQDKDAREKLWEWTQQEIKQHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE21</accession>
    <name>S0EE21_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_10137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435264.1">
        <property type="nucleotide sequence ID" value="XM_023567884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EE21"/>
    <dbReference type="STRING" id="1279085.S0EE21"/>
    <dbReference type="GeneID" id="35403603"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10137"/>
    <dbReference type="HOGENOM" id="CLU_010508_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF33">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT73186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="709" mass="78502" checksum="5947F08002837B32" modified="2013-09-18" version="1">MDTEDSPGIPRSSKRRRLNFACNYCRSRKTRCDEQQPSCQACLLAGVTCVTEDRRRPGKVIKRREAGKSTDGGSVTSASPSEYGLQTGAVERRHSVAEPRTIEVVNVTGPIRARSQSPRPSQSRDSSHTDTISNPLPIWRQSAGTTSFQILTEWLDLACFRLSIPYHFGSYPPSTLNPQAASQPQHGIPITPETWVPQTLFDAYAREIHTFYPVVRLDQARADVVQSHPGNLASHAVDIAALRSHLLFAAGGCILQHTERKTYMAETLSLSRNALGYLIGNVSYDTIEVLFLFSVCLRLNDEIISAWTTLGVCLSIAHSLGLNKPGKNRKKPLDLDAWNPAWWALYSYEKLFSFQLGYVSTISDDAFDTLELDVIKSTALEPSRIALSMASVFSKMSRRCATARQLEERASRRALEAVVKEKVTSTGEAFLMLTNWANSVPAGIRPTSDFMRVPENLGLASFVSLHYHNALIMLNRNSLLISKNALHMAVEIIAKDTPWEYQIRNGQSMVANSARKIIHLLADNDDSASHLFAPAYFPLLHAMYVLAVHILKQPHSRVSKIDQSLLVTAADLVRCYCVGISEEDRLNTILNGLLRVVQEAMKPIPAPNNNDSNTPALNSSTSLSDQNVTPLTDQQTFTEAVGQSDPAIASNTHFSMDEGILDPFSGQPFNIPILPDEIGCDWADFENLLQRLESEGPLYPTHEGMIIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEI4</accession>
    <name>S0EEI4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyl hydrolase family 30 beta sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_12945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435123.1">
        <property type="nucleotide sequence ID" value="XM_023567802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEI4"/>
    <dbReference type="STRING" id="1279085.S0EEI4"/>
    <dbReference type="GeneID" id="35406401"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12945"/>
    <dbReference type="HOGENOM" id="CLU_031530_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485845" description="Glycosyl hydrolase family 30 beta sandwich domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,6-galactanase-like" evidence="5">
        <location>
            <begin position="35"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="391"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="52302" checksum="1DD2E91265A2DF6D" modified="2013-09-18" version="1">MGPLARGLAALNLLGYLGSASVVAFPTDSKSDSEVLISVNGHVRYQELDGFGASQAFQRAEDILGKDGLSKEGTQHVLDLLFSKETGAGFSILRNGIGSSNSSDKNFMNSIEPFSPGSPGSKPHYVWDDYDSGQLTVAKEAFKRGLKFLYGDAWSAPGYMKTNHDENNGGYLCGVTGATCDSGDWKQAYADYLLQWVDFYRKSGVEVTNLGFLNEPQFAATYAGMLSNGTQAADFIRVLGKTIQKRGIRDLTIACCDGEGWDLQEDMMAGLTAGPDPAIDYLGVVTGHGYVSPPNHPLSTTKKTWLTEWADLTGQFTPYTFYNNSGQGEGMTWAGRIQTALVDANVSGFLYWIGAENSTTNSALINMIGDKVIPSKRFWAFASFSRFARPGAHRIEATSSFPLVTVSAFLNTDGTVATQVLNNDTVARNVQVVVSGAGRSPHSLRPFLTDNSNDLTALRHLKASGKGSFQTTIPPRSLVSFITDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEY3</accession>
    <accession>J7GLW4</accession>
    <name>FUS1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fusarin C synthetase</fullName>
            <shortName evidence="1">FUSS</shortName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Fusarin C cluster PKS/NRPS FUS1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Fusarin biosynthesis megasynthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Fusarin biosynthesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FUS1</name>
        <name evidence="10" type="synonym">fusA</name>
        <name type="ORF">FFUJ_10058</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2012" name="Appl. Environ. Microbiol." volume="78" first="7258" last="7266">
            <title>Identification and regulation of fusA, the polyketide synthase gene responsible for fusarin production in Fusarium fujikuroi.</title>
            <authorList>
                <person name="Diaz-Sanchez V."/>
                <person name="Avalos J."/>
                <person name="Limon M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22865073"/>
            <dbReference type="DOI" id="10.1128/AEM.01552-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Mol. Microbiol." volume="77" first="972" last="994">
            <title>FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Brown D.W."/>
                <person name="Kleigrewe K."/>
                <person name="Bok J.W."/>
                <person name="Keller N.P."/>
                <person name="Humpf H.U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="20572938"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2010.07263.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Chem. Biol." volume="20" first="1055" last="1066">
            <title>Genetic manipulation of the Fusarium fujikuroi fusarin gene cluster yields insight into the complex regulation and fusarin biosynthetic pathway.</title>
            <authorList>
                <person name="Niehaus E.M."/>
                <person name="Kleigrewe K."/>
                <person name="Wiemann P."/>
                <person name="Studt L."/>
                <person name="Sieber C.M."/>
                <person name="Connolly L.R."/>
                <person name="Freitag M."/>
                <person name="Gueldener U."/>
                <person name="Tudzynski B."/>
                <person name="Humpf H.U."/>
            </authorList>
            <dbReference type="PubMed" id="23932525"/>
            <dbReference type="DOI" id="10.1016/j.chembiol.2013.07.004"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Fusarin C synthetase; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C (PubMed:22865073, PubMed:23932525). Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production (PubMed:23932525). The roles of the other FUS members are yet undetermined (PubMed:23932525). The fusarin C synthetase FUS1 is responsible for the condensation of one acetyl-coenzyme A (CoA) unit with six malonyl-CoA units and the amide linkage of the arising heptaketide and homoserine, subsequently releasing the first intermediate, prefusarin, as an alcohol with an open ring structure (PubMed:23932525). The cytochrome P450 monooxygenase FUS8 participates in multiple oxidation processes at carbon C-20 and is able to use the FUS1 product as substrate, resulting in formation of 20-hydroxy-prefusarin (PubMed:23932525). This reaction seems to be essential before the 2-pyrrolidone ring closure can be catalyzed by FUS2, generating 20-hydroxy-fusarin (PubMed:23932525). FUS8 is able to further oxidizes carbon C-20 after ring closure, resulting in the formation of carboxy-fusarin C (PubMed:23932525). As the last step, FUS9 methylates the hydroxyl group at C-21 to generate fusarin C (PubMed:23932525). Fusarin C can then rearrange to epi-fusarin C, the (z)-isomers, and fusarin A and fusarin D (PubMed:23932525).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="7 8 9">Expressed under high amounts of nitrogen via regulation by GLN1 (PubMed:22865073, PubMed:23932525). Moreover, components of the fungal-specific velvet complex VEL1, VEL2 and LAE1 act also as positive regulators of expression (PubMed:20572938, PubMed:23932525). Finally, expression is induced under acidic conditions in a PACC-independent manner (PubMed:23932525).</text>
    </comment>
    <comment type="domain">
        <text evidence="12">FUS1 is an unusual polyketide synthase (PKS) fused to a non-ribosomal peptide synthetase (NRPS) module to form a megasynthetase.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="8 9">Impairs the production of fusarin C (PubMed:22865073, PubMed:23932525).</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="sequence caution" evidence="12">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="AFP73394" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JX308619">
        <property type="protein sequence ID" value="AFP73394.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="S0EEY3"/>
    <dbReference type="STRING" id="1279085.S0EEY3"/>
    <dbReference type="EnsemblFungi" id="CCT73260">
        <property type="protein sequence ID" value="CCT73260"/>
        <property type="gene ID" value="FFUJ_10058"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10058"/>
    <dbReference type="HOGENOM" id="CLU_000022_37_5_1"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-19357"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000437355" description="Fusarin C synthetase">
        <location>
            <begin position="1"/>
            <end position="3916"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="4">
        <location>
            <begin position="9"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="5">
        <location>
            <begin position="935"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 1" evidence="3">
        <location>
            <begin position="2372"/>
            <end position="2449"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 2" evidence="3">
        <location>
            <begin position="3493"/>
            <end position="3570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Malonyl-CoA:ACP transacylase (MAT) domain" evidence="2">
        <location>
            <begin position="548"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dehydratase (DH) domain" evidence="2">
        <location>
            <begin position="935"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="935"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1084"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-methyltransferase (CMeT) domain" evidence="2">
        <location>
            <begin position="1347"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ketoreductase (KR) domain 1" evidence="2">
        <location>
            <begin position="2092"/>
            <end position="2266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2487"/>
            <end position="2510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation" evidence="2">
        <location>
            <begin position="2522"/>
            <end position="2806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation" evidence="2">
        <location>
            <begin position="2975"/>
            <end position="3385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiolester reductase (R) domain" evidence="2">
        <location>
            <begin position="3612"/>
            <end position="3833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2492"/>
            <end position="2503"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="4">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="4">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="967"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1141"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="2409"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="3530"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="W7MLD7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="20572938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="22865073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="23932525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="22865073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="23932525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12"/>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT73260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="3916" mass="431028" checksum="983533C58D311E9D" modified="2013-09-18" version="1">MAGNQYLPKEPIAIIGTSCRFPGGANTPSKLWDLLCEKRDVQSRIPNDRFNVDAFYSTNGDKNGCTDVKNAYVLSEDIRVFDASFFKINPREAEAMDPQQRLLLEAVYEATEAAGLPMEDLKGSDTAVYVGCMTGDYHEMLMRDPQDMPKYMATGTARSILSNRISYLFDWKGPSMTIDTACSSSLVAVYDAVTALRNGVSKIACAGGANLILGPEMMISESKLHMLSPTGRSRMWDASANGYARGEGVAAIMMKTLSQALADGDHIQGVIREIGVNSDGRTNGITLPSPEAQKVLIRQTYKKAGLDFFKDRCQFFEAHGTGTPAGDPLEARAIHEAFFTDGDTVPEPMYVGSVKTAIGHLEGCAGLAGLIKALEAVKRGIIPPNQLFENLNPALKPYVSNLRLPTESKPWPKLTPGSPRRASVNSFGFGGTNVHAIIEQFDNVHTQTSSSDGIISTPLVLSANSDLSLRKQIAHFAEAIEHNDKGKIDRVIFTLTQRRSQLPLRTYFSGYDLQSLQQKLRDATAENAVLPFISQTVPPGRPPRILGVFTGQGAQWPTMGREILKASPFARAVIASLEESLASLAQPPAWTLTEQIMADKESSRLSEAAISQPLCTAVQIMVVELLRKAGITFNCVIGHSSGEITAAYTAGFLSASDAIRVAYLRGVCAKLAGGENGETGSMIAVGLSYEEASAFCEENFAGLVDVAASNAPTSTTLSGDKASIDDAKALLDAQGTFARILKVDTAYHSHHMNPCAQPYLDKLQAARVKSLPGDESVEWYSSVLGERITASLHGEALCDEYWVENMVNPVLFSVASELVAEASLPCHVALEVGPHPALKGPFNQTYKRATGSPLPYQGTVARNIHDVEGLSDSLGFLWSHLGKSAVDFTAYSQAFSPSITAMADGLPPYAWDHTQSFWRESRKSLNYRQRTQPPHPLLGARSVEDTADSMRWINYLRLDDVPWLEGHKVEGQVVYPAAGYLVMAMEAARAIDTTKGIQLIELSDVYILSAIQLTEGSQALETVFTLQVERNEPTFSTASWTLSTPMSGRNDSWKCNAKGQLRVEFGCSDDAARLPSRNKPIASLTSVNMERFYSALANIGLEYTGEFKQLKSIDRQLGLATAHVSQVVPDFPAMIHPALLDGAFQSIFAAYCWPDDGSLQAPFVPTFFRSLRIANTGHLRHGEDLVVDSFLTNTNERELTADMDVFQSSQGQPVLQLQGLTCTSLLRPGPSNAKELYTKTEWEVDIASGIAQSDTQDQDTASDLELVDLCERLSYFYLRELNNAVGREEVSGFDWHYRRIFEWIDHLFPLIQSGQHATIKTEWSSDSRDWLMQQSARFPGRIDLQLIQAVGENLPSVVRKQTTMLEHMVKDDMLNRIYKFGLGFERANVYLGRISKQIAHRYPRMNILEIGAGTGGATKGIMESLGTTFETYTFTDISTGFFEAAAEAFDHWADKMIFKPLNIESDPTEQGFPEGHYDFIIASNVLHATKSLTVTMRNTRKLLKPGGQLLLLEVTSDIVRVKLMMSGLSGWWLGGDDGRRYGPTIPVSQWDALLKQTGFSGVDKTVNDFVDAEKYMTSVMLSQAVDDRIELLRQPRLTFSDWLSSQSITVVGGYFRDIGRDILEILHQMNHGASQPVIHHVGSFEELALSNIQARSALVLEDLDEPILKDLTDDKLRGVQRLINESRQVLWVSKGCQRDEPFANMSIGMCRSLASEYPHIHLQHVDIEGRVSPMTASLLVEAFLRLVYRASLKSDDLVWSIEAELVLREDKWFIPRVKSDEALNNQLNASKMTIHSQKTLHGDTIEIQQRSNQFVIVDPVPCVPVSVSSPPVAITVTHSLLFPFQVGTKSSGYLCYGYTDSQPRTRVLAISEVNRSKVSVSPFSVWDLSSSEIDAADLLRKTALAITADRLLSDFEAGATVLIHESDELLGAALQWKAAELDLNVIMTTSESSRERSTGAMFIHALAPERLVNHIMPQHTKAVIDLSGKDYSIVGSPLRRCLPANCKFHQLQDILGNASQGVADPIIHGVRDASRSSLQLCGDGPVVKLSDLPSLRASIKDYATVVEFSANTTIPAIVQPLEGSRLFRSDRTYLLIGCTGGLGKALCRWMVSCGVRHLALTTRNVAAIDQVWLEELRIQGAQVNLYQADVSDKAALLQAYDQIVKEMPPICGTANAALLLSDRTFTELKVNDFTKVFGPKVKGTQNLHELLLDQKLDFFIMFSSLASVVGNRGQANYAASNLFMSAIAEQRRAKGLAASVMHIGMVLGVGYVSSTGAYEATLRSSNYMAISETDLLNMFSQAILVGQPNSTHAPELITGLNRFSLEPEAQKYFWRDNMRFCHHTLEEEHQERASATKVSISQRLSEAKGTAEILAVVEEEFCTKLERLLQAEAGFVKTSQSLLGLGVDSLVAAEIRSWFLKELEVDTPVLEILNTASITELCSTVVSHLPTISGEIAPKTEVTKQAIKTLNVVETSTAVSSALPTENEPFTIRNSPNSTQVTSEAGVDEDTSIHSKFDRAGPLSFAQERLWFLQQFLRDHSTYNVTMHYHISGPLRLHDLEMAFQQLIHRHESLRTSFFIDPDTDLPTQAVLKDSSFKLEQKHNSTAKIEYKAMQEMSYDLENGKVTKAVILPDSDGEFDLIFGFHHIALDGYSAQIMVRDLAIAYAGQTLPSKQQDYLDFAIAQKTAKVPDTTLAYWRSEFRELPPTLSVFDFAETKTRTPLTDYTTRALERTISIDQGRSIKAVAKCLDATPFHIHLAALQVVLSDLASTKDLCIGITDANKYDVTHIDTVGFFVNLLPLRLKISLSQTLAEVVANAKSKANSALSHSDIPFDVLLDEVKLPRSTTHSPLFQVILNYKMGSTQKVPLADCQAQLVAFKDASNPYDLTFDIETYHDGSACISVKTQEYLYSESELSFILDSYLQTLALFASEPSRTIDQICRPTAEQIDKALTLGRGERIPSPRLETLCHYFEEFVVKQPDDTALVTDKGQALTWCQLKALVNQIAMTFVEAGAKQDSRVGVYCEPSMYILPTLLAIAEVGGVYVPLDAQNPIKRLQLMVDDCQPDVILIDDSTATTARELETNAIVINVNTIKADPSNTFHMDIRARGNGMGYIFYTSGTTGVPKAVALTHTSLVHHFDGFIHYNNLSKCRMLQQAPLGFDMSLTQMTLAIMLGGTLIVASSETRKDPMQLAQLMLAEKVTHTFMTPTLALSVIHHGYEYLRQCVNWEHASLAGEAMTTRVTREFKRLGLRNLELLNGYGPTEITIIATCGSNELGDTLRDTHNPSIGRALPNYSCYILDENMQPVRPGLAGELVIGGAGVAIGYLNRQDLTEVKFLRDPFSPAEDIARGWTRMYRTGDKARFLSDGRLCFLGRIAGDSQIKLRGFRIELEDIASTIVRASDGKIPEAAVSLRGEGDSAYLVAFVILSQFNSPSDENGYLKQLLEELSLPRYMKPARIISIDQLPMNASGKLDQYALDALPVPHEEDIVDKPLTETQERLKLGWLKALPFIDAAIGPDTDFFSAGGNSLRIVSLREYITREFGVTVSVFDLFQASTLGEMAAKIDGSTTQGPTTMPIDWNEETRIDADLSIVGAQEPLPSETANDLQVALTGATGFLGVSILKTLLEDKRVSKVHCLAVRSSSNTSDPVFSSSRVACYPGDLSLPRLGLSQEQFDQLAKTVERIIHNGADVSFLKTYQSLKRSNVSSSRELARMAITRRIPVHFVSTGGVVQLTGQDGLDEVSVADSVPPTDGSLGYVASKWASEVILEKYASQYNLPVWIHRPSNITGPNAPKADLMQNIFHYSVKTASLPDLASWSGCFDFVPVDVVAAGIAGSIYETQDTVAYKHHCGREKISVEDLPSYLEAKHGKIETISVEEWLERSKAAGFDEVTAALVEKTLSRGGIVPWLRKEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF49</accession>
    <name>S0EF49_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to SEC7, component of non-clathrin vesicle coat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435659.1">
        <property type="nucleotide sequence ID" value="XM_023568464.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EF49"/>
    <dbReference type="GeneID" id="35403082"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09614"/>
    <dbReference type="HOGENOM" id="CLU_000691_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="625"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="570"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1550"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1804"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1822"/>
            <end position="1833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1833" mass="206615" checksum="C45BFA694C399540" modified="2013-09-18" version="1">MSSLKFVVSSLEAIASSKDAQRNKQLADSTTKALDAIKEQDQLPDPEIVFAPLQLASRSTNVQLTTTALDCIGKLISYSYFSVPSNPPEGTEEGAEPVPPLIERAIDTICNCFQGETTAVEIQLQIVKSLLAAVLNDKIVVHGAGLLKAVRQVYNVFLLSRSTANQQVAQGTLTQMVGTVFERVKTRLHMKEARLNLEHLKHGASNATFDQADTPNGANDSNDRDESPSEHSEAVNASTEPPESGVKLTLKDLEHRKSFDDSNLGDGPTMVTRLQPERRETGTPVSDQAGQESSPPEDGEVLDAEDEVYIRDAYLVFRSFCNLSTKVLPPDQLYDVRGQPMRSKLISLHLIHTLLNNNIAVFTSPFCTIKNSKSGEPTSFLQAIKFYLCLSITRNGASSVDRIFSVSSEIFWLMIKYMRADFKKEIEVFLNEIYLALLARRTAPLSQKLQFVTILNRLCADPKALVEIYLNYDCDQTVDNIYQTIIEDLSKFSTTPLTITTINEQVYEEMRLKTTPASEWQLKATLPPPLTVAHIAPHQEAEPDYPKEYAIKRLSIEALVETLRSMVNWSAPIRGDPEPPRSENHDPKASLDLRPSIDPSINDSISRVETPLPPSTPILEDDPDQLEKEKARKTALMKGINQFNFKPKKGIQMLLRDGFIPSDSPKDIAEFLIKEDKLDKAQIGEYLGEGDQKNIDIMHAFVDTMEFAKRRFVDSLRQFLQSFRLPGEAQKIDRFMLKFAERYVLGNPNAFANADTAYVLAYSVILLNTDLHSVKIAKRMSKEEFIKNNRGINDNADLPDDYLLGIYDEIAANEIVLKSERDAAAAAGNTPAPSTGIAAGLGQALSNVGRDLQREAYMQQSEEIALRSEQLFKDLFKSQRRKAGTKYILATSFKHVSPMFNVTWMSIFSTLSSQIQKSHNLEVNKLCLEGMKLATQIACLFDLSTPREAFMSALKNTTNLNNPQEMLAKNIEALKVVLELGQTEGNVLRESWKDILMCISQLDRLQLISGGVDESAVPDVSKARFLPPQRSETSDSRSSSNSKKTTRARAGTASKGFSTEIALESRSDEVIRSVDRIFTNTATLTGESMVYFARALTEVSWDEIKVSGSNDSPRTYSLQKIVEISYYNMNRVRFEWSNIWEVFGEHFNRVGCHNNMNIVFFALDSLRQLSMRFMEIEELAGFKFQKDFLKPFEHVLANSHNVTVKDMVLRCLIQMIQARGDNIRSGWRTMFGVFTVAARDPHESIVNLAYENVNQVYKTKFGVVISQGAFTDLIVCLTEFSKNLKFQKKSLAALELLKSLIPTMLKTPECPLSQKYNNIPPPDGAIQNSEKRSRSNTSVEEGYWFPVLFAFHDVLMTGEDLEVRSNALEYFFETLLKYGGTFPSEFWDILWRQQLYPIFMVLRSRPEMSNVLNHEELSVWLSTTMIQALRNMITLFTHYFDALEYMLDRFLELLALCICQENDTISRIGSNCLQQLILKNVTKFKPEHWNKLVGAFVELFERTTAYQLFTATAINNTASISPPPNGLEFSSTASATTPMDETSLKINGKEELEDDHSVPPPSAEDELQTPTADAPHIALEEFKPSSNLQQQPVVVTAARRRFFNRIISRCVLQLLMIETVNELFSNDTVYAHIPSAELLRLMTLLKRSFQFARRFNEDKELRMRLWREGFMKQPPNLLKQESGSAATYISILFRMFADNAPERLESRPAVEDALVPLCKDIVHGYTTLEEESQHRNIVAWRPVVVDVLEGFVTFPEDAFKKHIPDFYPLAVELLTKDLTADLRSSLLLVLRRVGEVGLGIEGMTQAGQRRDSEVSRATAEPVGDREADARRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF84</accession>
    <name>S0EF84_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to DnaJ homolog subfamily A member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_09566</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="434" mass="48065" checksum="A964C631F91560BB" modified="2013-09-18" version="1">MDENPFNAGAPGAEEVDLYELLEIDRTATPDQIKKAYRKAALRYHPDKVAEEHREESEAKFKEVTQAYEILSDEQKRELYDVHGMAAFDKSRGGPGGPEVDLNDILSQMFGFGMGPGGPGGPGGPGGARRPRRGPDEEQEYKVTLEELYRGKTVKFAANKQVLCGQCKGSGGKEKAKSSSCERCKGNGIVEAFRQIGPGMMRRETVICDHCQGAGQVFKEKDRCKKCKGKRTTQEKKVLEIYIPRGSMQGERIVLEGEADQYPDQTPGDIVFTLVEEPHDVFTRIGHDLSAELTVSLGEALSGFSRTVFKHLDGRGIHIERPQGKILRPGDCLKVPGEGMPMKRGETKGDLYLIVKVEFPEDGWLKSESEYHTLQKMLPPPPANIEAEEVDEVEYEDDADIEKMGENSGDGRFGGDWEDDEDDMGDGQAQCQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFE1</accession>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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            <end position="236"/>
        </location>
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        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT73711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFV7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the phosducin family.</text>
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    <dbReference type="STRING" id="1279085.S0EFV7"/>
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        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="138"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="290" mass="32604" checksum="32E54E24189E9161" modified="2013-09-18" version="1">MSTAAQEEFNDLVAKNTYRETLHPEDRDDPDLKNHQDLSEEDVFRNAQIDNAMRMPTVDRLTGAGASEIKLPPVSFDSGRATGVKGVIADARNYEAARKNKWRHRVRTARNSIFGIEAPTPVKSDTESSDDDAKSASDADEEAFLAEWRESRRRELESEASRSVRNRRTSPSVRIYGRLDEVDALGYLDAIEKVGRETTVVVFVYDHECEVSATIESALMPIVKTNPEVHFVKVHYEEIEFDNAAVPAMLGYRNQGDLFANLTGLIEMIPDDETFGTSSLKQLLQQHTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHA2</accession>
    <name>S0EHA2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to alpha-glucoside transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_10096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435300.1">
        <property type="nucleotide sequence ID" value="XM_023567928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHA2"/>
    <dbReference type="GeneID" id="35403563"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10096"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF57">
        <property type="entry name" value="MALTOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="64"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="539" mass="59406" checksum="0F75A39EECE8CD21" modified="2013-09-18" version="1">MSTNDDNKGISEVKGDGAHIDHAYDVEAKKEMAADMQGAIDAENAEHNMTVLEAVRAYPAASLWAFNMSCTIIMEAYCVFLIGNFIALPAFADRYGIWSDTKGKYVIETKWQSALQVGGPIGAIIGVTIAGPITSRIGYRWATISGLMLLNAFIFIFYFADSLPVMLVAQLLEGIPWGIFIANSPAYCSEIVPLQLRAPATQMLQMFWAIGAIIVGAVAYRYNDLHEQAAFRVPIALQWMFPTPLAILIFLSPESPWWLVRKGRLEEAAKAVRRLGRSTHVDNAQEAIAMMRRTIDLEKTVKEPSFIELFQGTDAYRTAIVCCVYAAQNLTGNLIANQAVYFFEQAGMPNKTAFAMGLITSALQTVFVMLSWILTSYFGRRSIYLWGSLGNTVLLVALGIAATVGDVKSTVNSNTQAALGLIVSVLFTLGPAPASWVIIGETSAIRLRPLTTGVGRGCYYLVNIPCIFLSSWMLNPTGANLGGKCGYVWAGTGFVCLVMAYIWLPEMKNRSYREIDILFKRKVQARKWKKTVIDVHDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHI8</accession>
    <name>S0EHI8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436332.1">
        <property type="nucleotide sequence ID" value="XM_023569065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHI8"/>
    <dbReference type="GeneID" id="35403763"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10298"/>
    <dbReference type="HOGENOM" id="CLU_092028_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="252" mass="28555" checksum="527569AFEA57117E" modified="2013-09-18" version="1">MNIDYYGRIAESLQFDNMPVMIATSACFAIGFLQYTYAIRLLIREGQGPMPFWMQTFYVAHELTFVYLFAEAAPRYDYHWFFVSTSFSLAVWAFLEMFCMWYTIQSPKDRIATFSPLFGRQPATSSILTYTFFLQLAMFALVWILIEFLGAGSFMLIGALTNVLLIIGPTHEYLSRGSRNGLSIGFCLTNVACVIWTFAPFSLGAVVLPEIFDQTVMYVAGFILLAYSVWLTTVVASYPPKTATKGQPTPIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHJ3</accession>
    <name>S0EHJ3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_14905</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436163.1">
        <property type="nucleotide sequence ID" value="XM_023568622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHJ3"/>
    <dbReference type="STRING" id="1279085.S0EHJ3"/>
    <dbReference type="GeneID" id="35408272"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14905"/>
    <dbReference type="HOGENOM" id="CLU_033536_13_3_1"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="9"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT74085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="240" mass="26661" checksum="F4E125862F1F6280" modified="2013-09-18" version="1">MATTKNKYSVILPTYNERKNLPIITWLLNRTFTENNLDWELIIVDDGSPDGTQEVAQQLVKVYSPHVVLKPRAGKLGLGTAYVHGLKFVTGNFVIIMDADFSHHPKFIPEMVALQAKGNYDIVTGTRYAGNGGVFGWDLKRKFVSRGANLFADTVLRPGVSDLTGSFRLYKRAALEKAIASTESKGYSFQMELMVRAKAMGCTVAEVPISFVDRLYGESKLGGDEIVQYAQGVFNLWLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ48</accession>
    <name>S0EJ48_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437099.1">
        <property type="nucleotide sequence ID" value="XM_023569955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ48"/>
    <dbReference type="STRING" id="1279085.S0EJ48"/>
    <dbReference type="GeneID" id="35404560"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11096"/>
    <dbReference type="HOGENOM" id="CLU_000288_138_16_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="511" mass="58766" checksum="C190A72F4BDDAF60" modified="2013-09-18" version="1">MRLINTTTLEVEEFFDVSIPEYAILSHTWGDGEVSLQDWADRKNRRFKPGFQKIVWACTQAAKDQLNHVWVDTNCIDKSSSAELSEAINSMFRWYRRSAVCYVYLEDVPAMTLDECTKPDSAFRNARWFTRGWTLQELIAPPNVSFFSSNWTMIATKSELAPCITEITGIPWSCLLKGRLSKAHPLRRYSVAQRMAWASRRSTTRIEDQAYSLLGLFDISMPYHSFFASRLQYVDFLPRSPWEFSDSQSVVVSSSPQLQRHYTPEDHSYSFHLTNTGLQITLPIVPTLVPNFVFGVLDCWDIETTSTTTTRHVSRIWIPLLRKGTGESQRYLRLIWPQTFFPVKMARKDSIMFQEEEELLPRDDHASADSEEPSDHVDTVSTAMQRSILVKKPYATILSVSTWQPREAGSPFLLCFPRGTADYRLYGIFPSDESDTAWASETPPVLPLIMPRRIHRGSHQVPDIELFGRAETDIYAAVVVFKKKRSKPPRFVAIFLSNIAQRDKKRDGFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ67</accession>
    <name>S0EJ67_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fumonisin cluster-longevity assurance factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_09253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435995.1">
        <property type="nucleotide sequence ID" value="XM_023568867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ67"/>
    <dbReference type="STRING" id="1279085.S0EJ67"/>
    <dbReference type="GeneID" id="35402722"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09253"/>
    <dbReference type="HOGENOM" id="CLU_028277_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="75"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="386" mass="44590" checksum="E7735AFB21E1BAE9" modified="2013-09-18" version="1">MALLFIDFSMPQAAPYTAKFLWLSHRQSSTGLYSIGNGDVCFVLFKVLTLSWLRESCMDYLLAPFAAAMGVAKERKRIRFSEQGWVLMYYTVFWPLGMFIWTKESHFANMDHLWTGWPQRDIDGLTKFYILTQLSYWIQQVISVNIEARRKDYWLNVVHHFITITLILVSYVYHHTRVGVLILVMMDAIEILFPFAKCLRYLGYTTLCDVVFCLFFITWVLSRHVLYLMTCWSVYSDVPRIMEVSCFIGSAGNLHGPLPVPDNWWHLIEPWLYPNGIVCHSNGFRISILVYLLLLQVLMMMWFGFICKVAIGVLDGRVVDDVRSDEESDEGSQITELEKDTNSFATVSSWQESRLQPRRSARSSSAAQIGNDGNGYLKRKAHGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJB3</accession>
    <name>S0EJB3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436957.1">
        <property type="nucleotide sequence ID" value="XM_023569793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJB3"/>
    <dbReference type="STRING" id="1279085.S0EJB3"/>
    <dbReference type="GeneID" id="35404415"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10951"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="355"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56329" checksum="BD833E4FD3853DC7" modified="2013-09-18" version="1">MSTANGRPRRPVSRADFPLAIICALSFEADAIEAPFDPFDEHWDCNVYSKVPGDPNPYSTGRIGRHNVVLAYMPEAGKANGAAVATNCRLSFPHVKLAIVVRICGAVPFSPGPRDAHHEIILGDVIVSQSVVQYDLGQQYSDSFEYKDANAEALGRPNIEIRSLLSKLKSLRARRAFESDVTSFLALLQEDLELAAHYPEPGTDRLYEATYRHIDKDMPCDKCGCNGKLVLWERLRQGVPEPKVHFGRIASGDTVMKSGQNRDDIARKLGVIAFEMESAGVWDSLPCLVVKGACDYADSHKAQATQNYAAATAAACNKAILHHWMVPTCHDPAGEENLPHFLVPFPPNEDFVGRQDILDDLRRQLSPEKSYALAALFGLGGVGKTQIALAYVHQLHAQSLDDSVFWIYASNEERMRQSCVAIMEQLKVPHSEGESDVLELMKQWLEAEHHKPWLMVIDNVDDLDLFYGTGGLSRYLPACAQGKLLITTRNRQVAVRATKGRGFIKYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJF4</accession>
    <name>S0EJF4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437204.1">
        <property type="nucleotide sequence ID" value="XM_023569200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJF4"/>
    <dbReference type="STRING" id="1279085.S0EJF4"/>
    <dbReference type="GeneID" id="35403882"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10417"/>
    <dbReference type="HOGENOM" id="CLU_418018_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="573" mass="66826" checksum="11EFF7D950AAF5B7" modified="2013-09-18" version="1">MLEQLPQEIFDFILNLLSMDDVKNLSLTSKHLHSATLEAVWESIVIPAWNKNGIFGIKLADFPLDRILLARHIYLRFIDEDYSRICLHSQKLQLCREAADESIIARPAAFSSVEEILISLLEECEKDYWKSFRNMYTGKVPETAIDLSAFTHLLDISWRGLNSENLKTLAIALRNNKSHLESLELDLIDWPHMRRELGYQSDSEVVHGLKARDYINEKVFGLDKLSPCIKFPNLHTLVLSQVPLSATLAETVDFEILKSLTIRSCPLWYEFVLTMAQRKIPVKLRKLELQESWPKNDEGSIYMDEDDPIAFLLDSFEGLEEFYLSQVGGMRSILTWHHVCHHKSTLKIFVNHSRFYEERNRRWWDQPDMMLRDWNTTPFKNNPTSTPLYQLDTEFISLSCTPKFPNDHYVLNPLSRKECLRVFHLRQSRSEMGPDSETWAVTIAEDEEPIDNAPAVDEGDNSSKEYLHCAFWTFIQWVFSPKGIKSLEYIVFGDYDRPERTSRGNLLICREGYGSQDFRIIRESYSAPEWDYIKKEYGDALRPCPSDPLFDTPEVQHSKHRWARFIANVTRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJQ8</accession>
    <name>S0EJQ8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436963.1">
        <property type="nucleotide sequence ID" value="XM_023569800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJQ8"/>
    <dbReference type="GeneID" id="35404421"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10957"/>
    <dbReference type="HOGENOM" id="CLU_065839_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="302" mass="34466" checksum="4611008826D71D93" modified="2013-09-18" version="1">MPTEFHLFPALPTELRLDIWDLAIAIRPKRAGVRVFRVFDASQEPSIQLEDVSGFTPNRTPLALGIPLPDKSFASVTGESISDISTQVHDPELWNTCQESRLMMRKAFVSRKGYSFDSMGYYLSGSAPFYVTITKPGHSLFILRPDSLEFDLREIYGAFSETDLVLGIEYKPEWGSQLYAEEQGGEICQAARLITGLGWDQTVSGVCLVDYNLKLKADSPYRPRPEDLGCYYARDRRLVEADPDDERKEEHWEYIDPIPDGDYRKSSFYFAKRMVEALDEVGMDDHEATFGPWIDLLGWDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJZ8</accession>
    <name>S0EJZ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_11034</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437038.1">
        <property type="nucleotide sequence ID" value="XM_023569886.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EJZ8"/>
    <dbReference type="GeneID" id="35404498"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11034"/>
    <dbReference type="HOGENOM" id="CLU_000022_31_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="38"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="926"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2308"/>
            <end position="2386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="926"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1085"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="958"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT74960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2386" mass="260142" checksum="E393F74D00BFB0A8" modified="2013-09-18" version="1">MTKSETITVASGSQTPGSGQGSQNEQKMVYANAATPDEDPLCIVGMACRLPGGIRSPDDLWDFMIQKKSAYGPVPADRYNINGFYHPQSNRSGSTNVPGGYFINEDVRQFDNAFFDINNLEATYMDPQQRKILEVVYECLVSSGTSMEAVAGSNTGVYVANFTVDYQPLQLRDPDYLHRYVTTGSGATIMSNRISHVFNLHGPSLSVDTACSSSIYAFHQAIKAIKAGDCDNAIVASANLILSPEPHIAAAKSGVLSSTGMCLTFDESANGYGRAEGVNAIYIKRLSAAVKDGNPDAKLDVAGTDYVECHGTGTAVGDPIEVEATGRVFDRGSGNQLLLGSVKTNVGHSEAASGLTSVLKVVQSFEKGQIPPTRGIVNLNPKLVLAERNLMIAQDARDWPRSLRRASINSFGYGGANAHIILESAESYLANKHPMGPSMTNAAISRQQRTVALPLSASSPYSLKALADDISSRLPRLGLANEIDSLAYTLTKGRDHLSHRTFILANLDKSGKILRSMRTTGDGDFHAMKPLPLGFVFTGQGAQYPGMAKELLASSELFCSTIRRLDSVLQALAPEHAPDWTLEETISDSSTTLINEVERSQPVCTAVQIAIVELLHSWGVQCNAVVGHSSGEIAAAYCAGIISASQAITVAYFRGYAAGKLTTSGSMMAVGLSDAAAEILIESKGLADQIRVACVNAPESVTLSGSHEGIQVLKQALENDNRFCRLLQTGGRAYHSSMMEEVGGLYEELLIPPFDEKAVRDGITCRPVGAVTMFSSVGPSIREKTPDMPVYWRMNLEQPVQFSSAISSMISGEGNLHLIEIGPHSALEGPIKQIRKHLQLTEASLPYSSALVRKQDADQCVKTLAGKLFSHGHSVNWDAVNTLPSMGLRILHELAPYPWDYTRNQGVLWSEPRASYEMRNRKFLRHELLGTRALTGNDIDYTWRNLLRLGEIPWLKDHCLEDQIVFPATGYMAMAIEALSQILDAKAKPAEEVSFEFRNVNISAALQIPSQERDVYSRDTDLELHTTMSGSKISNTTSSVDWHEFSISSWQAGRTMLHCMGNIRLTKPLTARDKHSVTLSEIDGFDKWSMNKWYAKWHEEGLCFGPHFRSLHSLQTDGGRSRRETIGITKLEPPLDGRGGTRYTLHPITMDAAIQAAALSTAAGHVDSLRAWLPVFISECRIQAPSSSVDVDVEIQATSEETGLSSRSISATVRDSTGKPVIDYTGLRVSLYTGKTATTVDQSTISQGGKNPPSDLYTQRNPTLRVTWKPDIQRLDPSGEDSMRSYITAFVDQQTEDVRDYESLSVMSALLDLAGHKNPRMRVLELGVDELVYKAKHWQSTLSKDTAFSRCRSWHVGTLTADGDVSLEPEDGKDPFDHDTSKQFWDRFPRRLSDLLSDQGIIITRTTSITATEFKASGFDVLDAGNQISLGVRPLQMPGTVPRNVFIVRAENASATVIELGEAISATLSGQVGISHVTSIKFHEVDTAEITDVDICISLLEMENEFLATMNSEDMERLRSITSTTTNLLWITGANMLGPTPNPNLTLSNGLSRALMLEQPALRFSILDVGSLADLNTELICSDVIKVLGRVHDRDDCEFIQMDGLLHISRYCPDIQLNSLFRRRLGLHAGRSLEPLASSHPARLSIDSIGAMDSLFFQTLSEPTSHAALDPGYVDVNVRAVSLNAKDVYAMSGRVDTQNMTTAFDFSGLVTAVGPDVSHVAVGDRVVVSAPHHLGTAVRVPAGSAHKMTSDEEFTVMPSMMVIYPTALYALNDRAHLRAGESILIHAGSGGLGIAAIILARRIGATVYTTVGSDVKREYLINELSVPSSHIFNSRDSTFVQGVMSATSGRGVNVILNSLVGDLMHDSWRCLADFGRFVEVGKRELVDAGRLDMSMFLRNATFTAFDLSELFYSQDQFHRSIWDRLISETLKLYRDGEIQPPPIKVFDVSQIAQAYRSFLGKDRVGKIVISMEDQQARVPVAPPLYLSVFDPEKVYLLVGCLGGLGRSLSRWMMTRGARRFVFLGRSGADRPSARQLISRLEKAGATVEVVRGDVCNLSDVTKAVEACVSAGRHIGGIVQAAMGLSESLFTSMSNEAWHTGIDPKWQGTWNLHNALQVHVDKDQTKEPDFFLLTSSVSGTVGTATESNYCSANGFLDAFARWRRSRGQACVSVGLGMISEVGYLHENPEIESLLLRKGIQPLNEDAFLQIVDLALNSEQGGRIDDSHLLTGLESAAIRELSAQGFDVTSHGVLNEARSSILLASVLAEKEAQDVVPQDGHVAVVTAAEWFKSISSALSPVFASVADSATLHIAIMQLIKTRFSNLILVPTDQISEDKPLPNFGVDSMIASEFRSWFWAVLRIDIPFLDIMSTKTTLGTLAELVEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK25</accession>
    <name>S0EK25_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to acid phosphatase Pho610</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437419.1">
        <property type="nucleotide sequence ID" value="XM_023570284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK25"/>
    <dbReference type="STRING" id="1279085.S0EK25"/>
    <dbReference type="GeneID" id="35404854"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11392"/>
    <dbReference type="HOGENOM" id="CLU_027977_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000064">
        <property type="entry name" value="Probable acid phosphatase Pho610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF15">
        <property type="entry name" value="ACID PHOSPHATASE PHOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485712" evidence="2">
        <location>
            <begin position="18"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="430" mass="48684" checksum="611F2701D6C18501" modified="2013-09-18" version="1">MLFQTATLLAVAGLALGHSYEPPKEHKQHKHETGWETSYTATGTAEVAAAAATAKTSSPTSKVKGKAFDRIAIIYFENENYEKAFGDPNFTWLRKKGITLENYFGVTHPSEPNYMAAIAGDYFGMQNDDFNRNPRNVSTVIDLLEHRGISWGLYQEDMPYSGFEGFSWVNHQNGKNDYVRKHNPAVLHDSIATSEQRLSQIKNLSLVDTEKSVFHKDLKENKLPQWMFITPNMTSDGHDTSVTVAGQWARTFLEPLLEDKHFMQNTLVLVTWDENETYARQNHILGILLGDAVPKHLVGTSDNSFYNHYSEIATVSANWGLDTLGRWDVGANVFKLVAQKTGDKIRKWKSHKLDSYFWNASYAGPFNTNGGNKEYVAPNLDLEHSFSGRKIFEPIRKEWKKSKNPTYYKDTIEVNDGLNPPKGYEPAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKI9</accession>
    <name>S0EKI9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable amino acid transport protein GAP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_11370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437397.1">
        <property type="nucleotide sequence ID" value="XM_023570260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKI9"/>
    <dbReference type="STRING" id="1279085.S0EKI9"/>
    <dbReference type="GeneID" id="35404832"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11370"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="83"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT75351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="587" mass="64850" checksum="F46AAFFF758F0634" modified="2013-09-18" version="1">MAYQREFEMQALPPSPKSRSPEPAVDDPSAWSRLITSFSRAPSRHDSLSSYNSYAFNGRLFNMSKANYNSANTALARELKNRHLQMIAFGGSIGTGLFVASGVALYRGGPVSLLLAFITMGAMQFFTMQALGELSVAFPVGGSFANYSTRFLDPSWGFAMGWNYTLQYLIVLPLEIIAGAFTTNYWNPNASKSIFIVLFFILILGINLLGVKAYGEAEFIFSAVKVTAIVGFILLGIIINIAGSPEGDYIGFTRWHNPGAFHNGFKGFASVLVTATFSFAGTEMVGLAAAETSNPKKSIPAAVKQVFWRISLFYILSVLLIGLLVPYNEPRLLGAKYGSDAAASPFVIAIEMSGSDVLPDIMNAVILISLISVGNTAVYAASRTLAALAEQSLAPKVFAYIDRTGRPLVAIICCGLLGLLAFTANSKIHNEIFNWLLAISGLSTLFTWSSICVCHIRFRRAWHLSGYNVSQLAFRSQVGVWGSWVALAAYGTVLVLQIWVAISPIQAEGEDPLTTPERFKNFFLQILTIPIIFLFYFTHKTWMGTKVVRDKDIDINTGRRYLHVWNEEEEQARRKWPLWKRVYNHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELG4</accession>
    <name>S0ELG4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436825.1">
        <property type="nucleotide sequence ID" value="XM_023569638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELG4"/>
    <dbReference type="STRING" id="1279085.S0ELG4"/>
    <dbReference type="GeneID" id="35404277"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10813"/>
    <dbReference type="HOGENOM" id="CLU_079110_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="32349" checksum="2BFA777FA406D92F" modified="2013-09-18" version="1">MADVYFALNGGGLTGSPPDPAITEPPEPYDKDILKRQNVGTYDVCGYYSIPGQFWVANYCYYSGVSTTTCATSSSHIGCDGYIKTRCFTSLTCTSTSSDELCCASGCVTAISTDSDGDELTLYPFCTTKDMEVAMYQNLEGVSASIETSIESTSEPTSSDGELTTKTGTTGESKTQEITSSAESSSSSGPDSSSKSSAPVGAIVGGVLGGLALLTLIGFGLWFIRHKKRQAGNGSHVVAATDQPPVVPYYQQQPVTHAQGEVNYQPLSSGTLPEPKAYSPSSNMRHSAFNELQSFHHDSTNPAGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELT3</accession>
    <name>S0ELT3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to D-arabinitol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438044.1">
        <property type="nucleotide sequence ID" value="XM_023571024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELT3"/>
    <dbReference type="STRING" id="1279085.S0ELT3"/>
    <dbReference type="GeneID" id="35405516"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12056"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT75998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="300" mass="32058" checksum="FC64068D6D344C78" modified="2013-09-18" version="1">MSPSALDTPTIVPSNGDTAPFPIPIPGTPTETSPTFLSTQPGPDHHWRVTLKDKVIAITGANRGIGLGIAEVCLANEAAAVFSLDLFEPGDEFLALHAANPKRLGYIHCDVTSEESITSAIDAIISKRGAIHGLVANAGMTKHQPALDFDRTQLDKLFNLNVFGAYFCATTVARRFIELGIKGSIVFTASMTSYRPNRAAPSAPYGATKGAVRNMAHTLAMEWAKHGIRVNSISPGFVKTAMTYFVDQAPDWDLKMQYYGGMPRLADPKELGGAYVYLLSDGASYTTGIDIPVAGIVGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM76</accession>
    <name>S0EM76_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoglucanase I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437977.1">
        <property type="nucleotide sequence ID" value="XM_023570943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM76"/>
    <dbReference type="STRING" id="1279085.S0EM76"/>
    <dbReference type="GeneID" id="35405443"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11983"/>
    <dbReference type="HOGENOM" id="CLU_063917_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF11">
        <property type="entry name" value="CONCANAVALIN A-LIKE LECTIN_GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39424" checksum="A0FC7A0A965FC4EF" modified="2013-09-18" version="1">MKVTTFVSYAILAAGASGKEEVKTVCGNQRYGELNDSLSYYPNAWNKKSPKNGFVCLKVDNSTPAFSATWNWTKDIQDVHSFPYVRFNNPDLPVRLSDLESIRLSTDWIYTPGSPSKIPDDFSNEVWEKNKAALEGDGVQANAAWDFFLDDDRNRTLYPQVAAVEFMVWLGRVGDPWWLGRQNNSILSNVTLGETEFSLFYGRNSGGTHVFTAVTKDNSDVLSFDEDFYPLFQYILEQAHKQIDADDLPKDPWLGIIEFGTETWMSRGNATFTAANFGMSLKGNFTSERNSTKKGDDDKDKGDNDKGDAKGGEKGSGDNSTDSKGDEEDDAVRLMSQSMLGYVIAAALVISTVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMB9</accession>
    <name>S0EMB9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438249.1">
        <property type="nucleotide sequence ID" value="XM_023571195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMB9"/>
    <dbReference type="GeneID" id="35407616"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14164"/>
    <dbReference type="HOGENOM" id="CLU_1378227_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="198" mass="22041" checksum="6A36C4213260D676" modified="2013-09-18" version="1">MPPKRRVSSRKRHRSPGVSPASRPTQAARLDNDDPVLSPVPEAGEPQGGPAGAGAEDCVYAEDDSHNVPGIHDQKLTERQLRLNDISENISQYYFALQEAKETLGADSLVVKVLTKVKDEACDLFKRVDAEGESDGKVPGDDVPEEKAEEQAEVPTLLQRQMNLESELFLLRANVFPMIEDLEKRVLALREEIEERQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMI6</accession>
    <name>S0EMI6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438324.1">
        <property type="nucleotide sequence ID" value="XM_023571213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMI6"/>
    <dbReference type="GeneID" id="35407601"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14149"/>
    <dbReference type="HOGENOM" id="CLU_164163_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004486068" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="13959" checksum="86E40503E09016A4" modified="2013-09-18" version="1">MKFFSALTFTASSLVLGTVAAPAPEPAAVGATVSPYSITCAGFNTGSPLSIGDIKWALSNRRDELDLKAGWWNQQDLTCVSTDGRKIQQYAVKFTYNHARSNPQGMTKLAEDRVLCTASNQWRLACSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENS1</accession>
    <name>S0ENS1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to putative tartrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_10376</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436406.1">
        <property type="nucleotide sequence ID" value="XM_023569153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENS1"/>
    <dbReference type="GeneID" id="35403841"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10376"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF51">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT74328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="531" mass="58975" checksum="395FDE691C916248" modified="2013-09-18" version="1">MASSGISKGHGTLDEKTHHVVPDSSSGEPPVKQHYNTVTRGESVPTSGDIDDNIVGYDGTLMGARTRLSSQQEKKLLRRIDWHLIPLLSVMYMVKSIDASNVSNARIMDRGTPRNIMTELNISADDYNFVTMAYYIPYILAETPSNLLVKRLKPSVWQARIMISWGIVLVCHAAVTNAAGLYTVRAFLGLFEAGLWPGMLLQLCYWYRPDEMASRIVLVTILGNFSAVVSGVLAFAFNGVHAQGLSGWKWLILTEGVFTILLGIYAYIFMPDFPDTARWMSEEEKAFVQARLPINAPRAAEKDFDWTEFWNTLKDHKLWLFLLCWAFYTIGTTGLNFYQPTVIANLGFTGIAEAQLLNIPPAIFACVLTIVFGWVANTGRFPLPLIPLSFMIIIEACYVVLYTFPNTGGVYAATVIAGGFSIAWYTMMWPWRVQTTDGATGSAFAIAFANSYGQIGGAVGSQLFNSRFAPRYTTSFGIAMGFIGMAIIMNVITWSFTWKVDVATRRLKRARDAAAKRNEAILDDVDIHAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENZ9</accession>
    <name>S0ENZ9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Saponin hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438080.1">
        <property type="nucleotide sequence ID" value="XM_023571070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENZ9"/>
    <dbReference type="STRING" id="1279085.S0ENZ9"/>
    <dbReference type="GeneID" id="35405557"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12097"/>
    <dbReference type="HOGENOM" id="CLU_446240_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496284" description="Saponin hydrolase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT76034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="68362" checksum="29602D03EBB66A6B" modified="2013-09-18" version="1">MPICPISLIALGATLLAPTVSGQYSPHFPEPPNPESIEIVELPLPPVVSINATGACTAKINPRGTGCIGVDTGGEQDFQSGDFTPDGKHIVANVVFIGAPAAPDPASIYDGEHLILITTDGTNFPNGDPWKCITCGVPSKNAPWLDPQRDYPHVFRSGDKALWGHNIISCGGHSLASDGCTPNNTHIYPIHWTVTADGSGKGDSPREMRLHPDDEHMGWSSFTNTGGQYTYFGRLEFNADPKAGEPLVPRYDLVDVNILVDKNGKPPMYVEGEKLTINHDAITSGELRGFSGSGDEILYIGSPVEANNIDVMAVHLTTGAIRRLTSHPDYTDPITMSHDNQWIVAMDTRVVGRQMFMSGMRWIPPIIDYLVVAIASSTRNNGPRRFFQPILISHDGDSGNYFGQQVNADGDGSDGSVNDPNWNGRADPAVSPDSTMIAYWQALVVSPSCGGTNPLPCPVSTAQGGRNYRVMLARRTSLKPSKPAPVFKAPDFIPWAKPFPAGSTSPKQYEIPAGNYTLEGQLSGIAEVSFIEDPDTGVIQTISASYSNYSDHTGYIIDGYEKVSKWKLLPNVWKDRVEWFSNITQTGVVDGTKVTSEDGFELEIDVSVNIMETNGTLTTILNGIEYVQPAAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP53</accession>
    <name>S0EP53_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436741.1">
        <property type="nucleotide sequence ID" value="XM_023569540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP53"/>
    <dbReference type="STRING" id="1279085.S0EP53"/>
    <dbReference type="GeneID" id="35404188"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10724"/>
    <dbReference type="HOGENOM" id="CLU_024469_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="51327" checksum="99AD6397C907DE2D" modified="2013-09-18" version="1">MTERQLEKIRPLGKLEQLSTIAHHIDFFTNTGLSAHYAPTQVLPGFDLEGTVYGALSQVLTQHPILFAIPVIPEKEEPYWGRLASINLEKVVSFVDRGQPCLAGDQTDDELDSLLERQHNTNFKSEYGTLPVWRLVILKDHDLSKGFTVSFIAHHSMTDGTGLQIFHDSFQKSLCDISSSSTEQAIDHVVFSNDGLIAPSLEELHPLPIPTSPPASNAAELNEWRGVPIALPCNTRYKSLSLPSNTMERFVQDCKTHRVAPTAALPSLVARLLYNNLPATAEVLTCNLPVTLRSDLPPKMVEGVMGNFIDAFKVQLLRSDLDQVSDDSSAGAFGIWNHAKKIQQATRKYFANASPSGEPYANVAALRLIPDIGAALTGSIGHPRGESFEVSKLGTFPQTKNVKGDAKLLWHRGKVLLSRCAYAGGAPLVVCVLNNEEYVGFGFTWQDGSIEESIVQAVINGIKTYLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ10</accession>
    <name>S0EQ10_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438131.1">
        <property type="nucleotide sequence ID" value="XM_023570768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ10"/>
    <dbReference type="GeneID" id="35405286"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11825"/>
    <dbReference type="HOGENOM" id="CLU_3068834_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="53" mass="5860" checksum="0E73529C4DCF9F0F" modified="2013-09-18" version="1">MPGRDPGISYGSSPDTKKMPGVLCPKCTTTEKQVWVMPGHPLLSLLRQRDSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHE8</accession>
    <name>S0DHE8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423565.1">
        <property type="nucleotide sequence ID" value="XM_023577228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHE8"/>
    <dbReference type="GeneID" id="35395520"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02037"/>
    <dbReference type="HOGENOM" id="CLU_013985_24_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="57"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="264" mass="29836" checksum="06E0D7A0DEE04D98" modified="2013-09-18" version="1">METMAPLHHALPPLEVFVSAEDFENLGMTPWFSYSVTLPERPIPSASDRPPLETERLLIRPLTMNDLDAFHELRKRPDIQNHSTARGRATKDKDETERQLHSLVQDDQSHWWFGAFLKSTNELIGEGGLPDVLAMSSSISGWPEAEFLIKPEFRRQGYGTELWTAVMNSWWDLPRERRRHQLVPVVAPGKEPGDKMDECVVFQWEAGNEAAKNFFAKVLSQAPVAAQGGCESIDTRDGKEGNLITWAGTIICNPRPMPEEEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHN5</accession>
    <name>S0DHN5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423542.1">
        <property type="nucleotide sequence ID" value="XM_023574450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHN5"/>
    <dbReference type="STRING" id="1279085.S0DHN5"/>
    <dbReference type="GeneID" id="35395545"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02062"/>
    <dbReference type="HOGENOM" id="CLU_008809_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF6">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="631" mass="67744" checksum="C1ED202DD33A5F22" modified="2013-09-18" version="1">MAIHKLTPILMTGSLFLGLLLAIGHHLYYQYLDGRIIKSQNQQEWFLRVGTGIAFLARALLSAAVGFAYTQILWRTLRSRSVTIEGVNSLFGVLHNAWDFTAWELWTAAPALAVVAIIAWALPLIAVITPATLTVQVSDRPNITVVDAPIPLLDYDNMLNFAQFTGVGGVGYYAPSSYVSRVLLSVASLGSILTIPAPFPNSSYSIDFYGPSISCNTPRNATFAKLLGDTVKNETCCGNSVGYVGFVPSSNTINRTVEGYALAGLRGAMNYSLISTVASIDQTANATSSAKLYVVVPDKPASSSYILANKSIECALYNSSYAVNFIFDNGRQNITYKSKRLNGVTSTDAGLNQDTGSSQFNAAVAYIALMDSLGKLLLGSLGISHYGVMRATQTQIMSSILMDAKEMQVLGGVNAATDHPTAPDSVIGNISMADALEQLFTNATISLFSNSQLLQNDTTASRGNITYLTAQIAFSYEPRNLFIAYGLGVLASAIIVIIGLLCIKSASASYATTFSTILRTTRNPDIDTIVPAAETSGAEPLSKHLGDTRLVLRRQERKLEGMGDDMVTLFAVDSTPDEKGRTKDSPYDSSHPGDRGQQYSDVSIELLSHVDHSVTDARTGNGGRKLFTRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHW4</accession>
    <name>S0DHW4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423667.1">
        <property type="nucleotide sequence ID" value="XM_023573262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHW4"/>
    <dbReference type="STRING" id="1279085.S0DHW4"/>
    <dbReference type="GeneID" id="35395410"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01927"/>
    <dbReference type="HOGENOM" id="CLU_015320_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="361"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="595" mass="63032" checksum="447E8DC0C661B942" modified="2013-09-18" version="1">MSNPEKAPQYSAGDQHGGGLLPTADPSHNQPQDSSLPPAYNQGSAELPGDEKPRVPQNPDQHVQFSGSQSQQQPPPFTSTTGTEQYPSAAEEKRQLEQQYFPPPPPGPPPAQDQHQASAAHPNPLQGNPVAVPQQHQETHQPFDAQQSQQAPQNYAIPQYDPAHPTFAPPPTNQPAQAQAPPQPSPTAPTHGHGFGHGPETTTTQASTSAHPETHKKPGWSEKFSQLGIKAAAPINSLAHKFGSQSFLPETIDKECDKAASILKSFCKNGVYADPSSSQVPTSTDPKAQETNDEIIDPTKEKPKKRVLVNIPPKVIAKAQGLAIFTTLRAGYAFSGATGSGILISRLPDGSWGPPSGIQVHSVGAGFMIGLDIYDCVCVINSREALNAFAKTRVALGSDLAVVAGPYGAGGAVEIGAAMDGKKKDKDNKDEEAPPKPPRPTEDNQGLKPETDADKKKKRRSLSTGAFKPVFSYVKSRGFYAGIQVDGTVVVERKDANAAFYGERVSVEQIIRGEVPRQSGMWPAGARNLLETLKGAEVGSLKVNSVSPTDRDPTSTGPSDPSAPVASGASAGQTQPPGYVDDGVHRPEVGDVKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI36</accession>
    <name>S0DI36_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_01810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423787.1">
        <property type="nucleotide sequence ID" value="XM_023574573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI36"/>
    <dbReference type="STRING" id="1279085.S0DI36"/>
    <dbReference type="GeneID" id="35395294"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01810"/>
    <dbReference type="HOGENOM" id="CLU_015355_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT61706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="574" mass="62393" checksum="51C279CB01B859A3" modified="2013-09-18" version="1">MAVFAQYDYLFAVGTIFAFLDAWNIGANDVANSWASSVSSRSISYFQAMIGASIMEFTGALGVGGRVADTIRTKIVDVEAFDDSPALLMLGMVCAVVASASYLTFATRCGFPVSTTHSILGGVLGMGVGALGGSGITWVGYKEDGSLDIQQGVVQVFLAWIIAPMLSGIFGASIFLFTKYCVLLRKSPAIKGLILVPFYFWATASLIVMLLIWKGGSYEVNLTEEQIPGVIVAAGAGWGLLMAIFLVPWLYRIVIKEDWQLKAYHIFLGPLLLRRGPVPPTPDNFQGVVRNFYEGHLTREELEERRTQRAAALGEDLEAGGNDKKVITEQATEEPAVNPYQHKSMIGPKPDAPWYTGAFMWWAFKFAILHGVDKDIVGSQSEKSVVAGDVEEIHARAEHFDNRTEFLYTFLQVMTAASASFVHGANDVANAVGPYASIYQIWQSGAVPGSKAQVPIWILAFGGAGIVLGLWTYGYNIMRNLGNRVTLMSPARGFSMELGSVITVILATRLKLPVSTTQCITGAIVGVGLCNGDWRSINWRMVGWIYLGWFITVPTAGLISGCLMAFITYAPNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIM3</accession>
    <name>S0DIM3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_01414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424151.1">
        <property type="nucleotide sequence ID" value="XM_023578983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIM3"/>
    <dbReference type="STRING" id="1279085.S0DIM3"/>
    <dbReference type="GeneID" id="35394899"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01414"/>
    <dbReference type="HOGENOM" id="CLU_059964_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="282" mass="30146" checksum="DC833BB140D2C982" modified="2013-09-18" version="1">MMSRLSAMQASNRLRTALLEGKKAFGAWQMLPGANVSRVLARSGVDWVLVDCEHGNLDGLTCQDGAMHDAVPAIAALGVSPIVRLPDMQGWMVKRALDSGAHGTKIVVPLLRTPEEARQLVQSAKFPPLGRRGFGSPIAPERFHPEPSFSEYLQQANDSLLTIVQIETKEALESIDEIAAVDGIDVLFIGPFDLGNALGHPIIEGVMATELKDAIAKILAAGQRAGKKTGVYCTGGEQAKIYADQGFDMMNVVTDYTSLGLVAKEQLSFADGSLAPTRGKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK31</accession>
    <name>S0DK31_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424836.1">
        <property type="nucleotide sequence ID" value="XM_023572574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK31"/>
    <dbReference type="GeneID" id="35394146"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00661"/>
    <dbReference type="HOGENOM" id="CLU_903265_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT62755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="273" mass="31154" checksum="566EE19CA2B349FE" modified="2013-09-18" version="1">MLFPKSKRASAPGFKICFNDNSGAGHRIFHLDIKDVRKWRDAFKPKRLDTKADRRRQDTRASMGQWAIANSSFVICNQEDTPTPEREPVSMDSGSPCESLIFTMEKLDLLGDTKCNGTVDVDRVAERVKTERILEGTLTPDPDRDYEGEFTLLFLSFEEAQRERQPDIVDDGSKGWKFLHGIITAGQRDEPSELPAYHPSQRAFLLARKFRGAFLVTCSIRNIDACSHAELLKLIWQMEMTGWNDMICHREGRGGPLPYRKQEKSRRVGLGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK89</accession>
    <name>S0DK89_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="5">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">FFUJ_00583</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="5"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424906.1">
        <property type="nucleotide sequence ID" value="XM_023573132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK89"/>
    <dbReference type="STRING" id="1279085.S0DK89"/>
    <dbReference type="GeneID" id="35394068"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00583"/>
    <dbReference type="HOGENOM" id="CLU_013299_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="27">
        <location>
            <begin position="357"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="27">
        <location>
            <begin position="604"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CCT62825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="764" mass="86323" checksum="59E37B9F370F0EFA" modified="2013-09-18" version="1">MSEQHDAQMGGVSPGNAHAELAADASNITTSTKDEERASKRVKVNDSIPSQSVPGEDLHDARAPKENQQSSNGDKENEVPRPQSDSKTEYVDGRSKGVAPIKKEYLVDMSTQKDASQDAVNDDDAAEARGTAEGNAENGDRKPGKGRKEKKKKGQNTERDFGKFDDAFRLCNSRAFYPEFSPRECKFGDRCRLCHDIRKYLEEGRRGDVETFEGKCPVFEAHGHCPSGWKCRFVKSHMKEIEHEDGRKELVLTSTSADSGENGEPKDEGSEEQRPAIFNVVSMDKKIDLNRKRTDFKRSDQYITWLNNEAKLSEEFMNRRKNQSTEGIEDLRARFIDPPFKPSEKRRLYFGPETPTLAPLTTQGNLPFRRLCVELGAQLTYSEMALSMPLIQGTKADWTLLKVHESELSPPKFNPGSVPIFDDYDHSKDIKFGAQISGNNHWVVTKAADVLNRYCPHLRLIDLNCGCPIDMVFKSGGGSALLENSGKLERMIRGMNAVSGEVPITAKIRTGIRNSRPTATQLIGKLAFGAREHRERLGAPGCAALTLHGRSREQRYTKKADWGYISECAALIKTYNKQKDSLTDTIAEPDASSLPNAKDGRMYFLGNGDCYSHTEYYEHIEKARVDTVMIGRGALIKPWLFEEIEKCQYLDKSSSERLRYIEKFVRYGLDAWGSDELGIGFTRRFLLEWLSFTHRYVPIGLLEYLPPCLNDRPPKYEGRDEMETLMASNNFRDWIKISEMFLGPVHPTFKFQPKHKSNAYEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKM4</accession>
    <name>S0DKM4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425225.1">
        <property type="nucleotide sequence ID" value="XM_023573519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKM4"/>
    <dbReference type="GeneID" id="35393720"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00235"/>
    <dbReference type="HOGENOM" id="CLU_098389_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="190" mass="20999" checksum="78BB31B8BE976C9E" modified="2013-09-18" version="1">MSLTFRPATPQDVTPLRALVMSAYRGPDSRAGWTTEADLLADERISPTDLLAKITDPNGAVILAFTSSPSSSGTSTPEGDSDPRLVACCEVVQKDSERAYFGLFAVSPKLQAGGIGKQVLGYAENYAVRNWGTKIMTMWVIWTRKELIDWYVRRGYVKTGEKSPFPYEGLVNGKALRDDLYFDHLEKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLE9</accession>
    <name>S0DLE9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425327.1">
        <property type="nucleotide sequence ID" value="XM_023573638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLE9"/>
    <dbReference type="STRING" id="1279085.S0DLE9"/>
    <dbReference type="GeneID" id="35393613"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00128"/>
    <dbReference type="HOGENOM" id="CLU_362919_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="4">
        <location>
            <begin position="244"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="770" mass="87049" checksum="B6FAC9360CDA1102" modified="2013-09-18" version="1">MHVIEAPNCEPNCVAAKNLSITLEALLTLATSKATPQERLEVSETFKQVVKYIQHILKQSHDRSAIDAVCEPIPISMPLPIADPQTRSPAEDAEQDQAGVSESSQTFGLEENKSVSARKFSEGRVVLTRDDMGEKMPETLHRLLQSPGFKNPAKLSFIGEETGKECIRQAMEREKHPDVRYNLLTPRAEGGMKVTKSEPPSGDAAELPIVNLDSSLPYSPLDEAVASRKTRTVCHFAGIIDCDHPIYKNTPLHSGPLLAGMANVLTHANQTYTHFGDAGSATAMHKEDDRFLSYNIVLFGLKKWVMIRKEETEKFENWVSLYNKTCRCDQFVRHLNIFFNPEELQKAGIGYDIITQGPGELVVTQEYQYHQVFNITPTLAIATNFLPPGVQPRVKSEQERLKVCSLCGIGGLYGLEEFYVDWVDDTFRPDGSQKRKLMIGHGVARRRKKTQRWEPAVSARQTRQFTRRHKAEDRVTDDRGTVDRVVSRRLETVVNGTADDRGAVQEDGPANDVMRRAMKELERDGEFVLIPELSNNTNSGTRVNRLAMAVLSKHAIEQFITAIKVSKQKPEDFRRTPIASLQDGNNTEQQIIKLVAERVKLISGDENKGNYYTILTRHNLFQFAARYALLRGERQHIRKDVLDMVAEISGCTKSTIQKRAQIGDKWKMVCGRLTDGAGLLAFLPCRDSPFDVSQSFYLDLAKEKNREDLDMFHRLLDHQYVRELCMIANTWFDAVDGGKELADVEDIDVQVSDKDEIIRYLWRLVQTKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLR1</accession>
    <name>S0DLR1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to monocarboxylate transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_00258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425462.1">
        <property type="nucleotide sequence ID" value="XM_023573493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLR1"/>
    <dbReference type="GeneID" id="35393743"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00258"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT63381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="451" mass="48620" checksum="E1F7583DB640A291" modified="2013-09-18" version="1">MSQTSIELRQDPGREEGFASSGLDLTSTHENEVSSLPPVDGGKDAWLFLAASFMVEALTWGFPFAFGVFQDYYSTNAPFEGSSAIAVIGTCAMGIMYLGLPFTMSLQRLYPRQSRWSPMIGLFIMCIALALSSFSQNTTHLILTQGVLYAIGGSISYCPCILYMDEWFAKRKGFAFGIMWSGTGLAGFALPLLFEKFLYEYGFRTTLRIWAVSLFLLTLPLAYFIKPRLPYSATRHINPLKLGFALRRNFLLHQLANIAQALGFFLPGIYLPSYARTALGAGSFASALTVLLVNVASVFGCVAMGALTDRLHVTDCFMISAAGTTLSTFLLWGLSTSLPILYVFCIFYGIFAGSYTSAWTGIMQMVSSTPSNTRTSGTSFDPAMVLGVLSAGRGIGNIASGPLSGALIKGMPWQGQAAGGYGTGYGTLIVFTGATALASGATFVFRRVGWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMC6</accession>
    <name>S0DMC6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to 3-phytase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425860.1">
        <property type="nucleotide sequence ID" value="XM_023571577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMC6"/>
    <dbReference type="STRING" id="1279085.S0DMC6"/>
    <dbReference type="GeneID" id="35398543"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05062"/>
    <dbReference type="HOGENOM" id="CLU_013427_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003431">
        <property type="entry name" value="B-propeller_Phytase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02333">
        <property type="entry name" value="Phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50956">
        <property type="entry name" value="Thermostable phytase (3-phytase)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51662">
        <property type="entry name" value="BP_PHYTASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494976" evidence="4">
        <location>
            <begin position="22"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="6">
        <location>
            <begin position="16"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="6">
        <location>
            <begin position="393"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="749" mass="81201" checksum="5913BD0FC0106647" modified="2013-09-18" version="1">MVGSSLVGLLAVVFQICFVKAVDVDVAVSAYTSEVESDWTAVYYSDRNPLLIGNDGGPDKGGFHVYDLNSKAPLKEVAAKTPGRSKLVTTVYDVNKKDIIVTIAQPDSIVRAYEMPKFKQIRDADFKVLGDWSALCSWKSPAGNDYVFLFGKGQAVQLLLQETKKSFEFVQIQTFPTDFETSGCAVSRSESRMYISTDDDKSVYAFSLKESTKVPKITKVGKAEDDVTGLAVYVPKKGSDYLFVAQTDKIAVYDSSFKLKGTLSLTGQEDIEVQGLNIYQGATSKYPAGALTYAIESEDVNGFAVSSLENALKKLKIEANTKYDPRKVKTDTKTEPICKTCGGNGYCIKDKKNKCECFAGFAGSTCSSFTCTDKCSGHGKCAGPNECKCDKGWGGLHCSFLLIEPTYETESRLGDGDDPAIWISPDGPEKSRIVTTMKSGKEAGLGVFDLAGNLLQSFTAGEPNNVDMIYGFKAGNRKVDLAFAACRADDTLCLFEMLPNGTLTNIAGGIHPVVDDYKVYGSCTYKSPKSGKQYLFVNEKSARYLQYELTSTSKGELQTKLVREFQGGSGGQVEGCVSDEENGWIFLGEEPSALWRYDAEPDSKDKGVVIGKIGDGKLYGDVEGVTLVYGSKPTEGFILVSCQGVSAYNVYRRAAPHEYVTTFTLVESSDGQIDPVSNTDGITAVGTALNKDFPHGLVVVHDDANQLPNGKTSAEASFKLVSLEKILGSKVLGKKGLLDQVDKNWDPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMH5</accession>
    <name>S0DMH5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424628.1">
        <property type="nucleotide sequence ID" value="XM_023569986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMH5"/>
    <dbReference type="GeneID" id="35394379"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00894"/>
    <dbReference type="HOGENOM" id="CLU_057894_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="132" mass="14884" checksum="518AD7CCE2199963" modified="2013-09-18" version="1">MTGFENLCLDLSGPWTDGPNAALKSFCVEMGKHLKLKTLVVLGLLVRQEYCKLGKDFWAKTLENQEYVPSTVVKSHSEDSGESDESDESDESDDDPDEELVGFPTYIYWLKDCLQPGGQIHFVIQYESETEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN19</accession>
    <name>S0DN19_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_01552</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424029.1">
        <property type="nucleotide sequence ID" value="XM_023577439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN19"/>
    <dbReference type="STRING" id="1279085.S0DN19"/>
    <dbReference type="GeneID" id="35395037"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01552"/>
    <dbReference type="HOGENOM" id="CLU_031900_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="383"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="168"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT61948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="438" mass="47323" checksum="97FA7F3AB71E119F" modified="2013-09-18" version="1">MPRDDLSIDFVKRMPQAEALDPGLILDDWINRVQNLPEEIRFIQEEVADKDRQYSECLRTIEDRDGKIQKWIKTNGSHEPNPKEDLLRKQVRDSFAQADQLSKEKIALCQKMQIIVDKHLKNLDSQIKLLYDRAEPGFTDPDEVPSLLRPSAANHTAPSIRAINPASHMTTAAGPSTPLAAAQTSSNPALARLPNHPNVRHAQSQQHAASAPATPAASMILNRQREGSAGPATKRVARVNPALGTIPTTSSGLARHSSLGPGTPKGSAIVGSGLARAGSAGPRTGSVKSTGPLSGRRGTPTGGIRKKSANKSNLSRVKKASNRNSPAPTNDSELSDVDSGSGEDEDGADGRSRSTPVADGKDVDGDDIIGDADDDDEEAGDDKKYCLCHNVSYGDMVACDNDNCPYEWFHWSCVDLKSEPNGTWYCPKCRERLQKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN58</accession>
    <name>S0DN58_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to FMO1 Flavin-containing monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426095.1">
        <property type="nucleotide sequence ID" value="XM_023571859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN58"/>
    <dbReference type="STRING" id="1279085.S0DN58"/>
    <dbReference type="GeneID" id="35398290"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04809"/>
    <dbReference type="HOGENOM" id="CLU_023116_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="6">
        <location>
            <begin position="567"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="738" mass="82300" checksum="871E2DDADCF6F9A3" modified="2013-09-18" version="1">MAMTVCIVGAGPSGLVAAKTLLHNTAPGEFKVTIFDAQKDIGGLWPTSKRDNGRQVHPFMWANQSRHTMQFSELAWEDSDPQLPQGWMVGKYLHRYLERFLKSNKDFELKLGTRVESAERPEGSSNGWVVNTKSGAGTGSKKFDYLLVASGFFGKPIMPESLEKQTAIPVVHSSHYRDVKSLLGEGRPGGGKILVVGGQMSGVEIAGTIGAHLSSEANSPDPSRITDIDKYSIHHAIQRPIWVFPLYTSPKPAEVAAPFLPLDFSSYNLNNRPRPLTNTQGHIPEATAKVVHSVYKGVLGSDQSEYSPLLKIHGTNDDKQPYLAVSEWYTDFVRSGMISLSKGKVESLEGSTATLSDGTKIEDIAAVVVATGFDASPCINYLPGDVLKALRFSPKHIDQPVALAFHGTYHPEVSDLGFVGFYRSPYWGVMQMQARFVAALWSDNVSPGRESESFKTKLRDDISIQRTLELRDDPRVSQFPMGDYPYLVNEIAEALELKIREPLEPPVPSLPHNNLPLDMLTPARYSNTTDDQDSKDAATKSLEQTHKDATDGLTTSRFVAHAVFRSLLGTWKLERDLVSKLPSHPSGHFSGTAQFLLREKTNDGLRCAGNPSEDSPSDDELGMEYLYIEEGEFKTEQGFGFKATRRYVWRYDELKDVLSVWFAKPEDLKRADYLFHEIEFTEPTSKGWKAKAGHLCIDDYYDVKYNFAFQAVNLKEWGIEYTVKGPKKDYTISGTYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNC1</accession>
    <name>S0DNC1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to IST2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426155.1">
        <property type="nucleotide sequence ID" value="XM_023571932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNC1"/>
    <dbReference type="STRING" id="1279085.S0DNC1"/>
    <dbReference type="GeneID" id="35398226"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04745"/>
    <dbReference type="HOGENOM" id="CLU_010867_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="179"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="738" mass="83539" checksum="D2F79AE1519329C4" modified="2013-09-18" version="1">MSNLKDLYSQSGDESQTSNFGVDFVIHYKVPPSERAEAEAGFVQLVQALTTVGLATEVRHGDNNSLLVFVKVASPDLFAKQVYRARLADWLHGVRVSAPHSDVRQALHDEPVVEAERLRLIYIMITKPRNEGGAGITPSNAKWKYVESIFPLHSHKFNKDWIKKWSSKYILEQSDIDDIRDKFGESVAFYFAFLRSYFRFLVIPSGFGFVAWLLLGQFSFLYTLLCGLWSVVFLEYWKKQEIDLAVQWGVRGVSSIQQARPEFEWDREAEDPVTGEVVKVYEPMKRIKTQLLQIPFALACVIALGALIVTCNSLEVFINEVYNGPGKQYLGFLPTILLVLGTPTISGLLMSAAEKLNSMENYATVDAHDAALIQKQFVLNFMTSYMALFFTAFVYIPFGHVLVPFLEFWRKTAQVVTFSEKPLPTREFQINPARISNQMFYFTVTAQIVNFATEVVVPYLKREALEKAKALKSQPKVQDDHEEEAEFLERVRKESALETYDVSGDYREMVMQFGYVSMFSVAWPLAACCFLVNNWVELRSDALKIATSSRRPIPWRTDSIGPWLTALSFISWLGSITSSAIVYLCSGARGNGNHGEPSPLKAWGLLLSILLAEHFYLVVQLAVRFVLGKLDSPGVQKERKERFLMKRKLLEENIGQGASEESSVPGIDHSEKITREALEEEARQTSIRGHGTPEEMFWQRQRGMNETIDVGRRMIEQQKAAAEKNGKAKSAVPSMKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQU0</accession>
    <name>S0DQU0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427010.1">
        <property type="nucleotide sequence ID" value="XM_023572982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQU0"/>
    <dbReference type="STRING" id="1279085.S0DQU0"/>
    <dbReference type="GeneID" id="35397286"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03805"/>
    <dbReference type="HOGENOM" id="CLU_025711_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="224" mass="24026" checksum="725E8B757B4BCC57" modified="2013-09-18" version="1">MHFLLLGATGRTGKYVVSELLSQHHTAVALVRDASKVASQPGLTVVTGSPLSKDDIRRALTAAPGLVISATIITLNTVRKSDSPFAAQVSPPRFLADSCANACAVLKEAGIKRIAIMSTAGVGDSWGKLPWVSRAFMGWTNIKYALEDHNLLDKEIRSTGMDWTLVRAVRLEFGKETDKEVETLGSAGEGMGMSDSVTPNSVARFLVKVAVERSFVKEAVVVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR84</accession>
    <name>S0DR84_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_04901</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426008.1">
        <property type="nucleotide sequence ID" value="XM_023571758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR84"/>
    <dbReference type="STRING" id="1279085.S0DR84"/>
    <dbReference type="GeneID" id="35398382"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04901"/>
    <dbReference type="HOGENOM" id="CLU_018152_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT63927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="610" mass="69093" checksum="FC5737FC95DA7E9D" modified="2013-09-18" version="1">MAPGTAQQSQQRQFVHPTASHAKKKAPSAYSMQPISAFYWFFGAALVSAWFAPIQDCDETFNYWEPTHYLSHGYGLQTWEYSPDYAIRSWLYIAFHAFVGNVRRIFPHSNKVAEFYFVRFGLAFVCAITQTILFMVTSTTLNSRIGLFFLIATVASPGNFHASTAYLPSSFAMYLVTVGAAAFMNWRGGLKTSQGMFWFAAAGILGWPFAAALCAPFMLEELILLVFGDKTALWEAFVRIGRGVVSAILLLAGDYFVNLFFYKKAVSVTWNIVKYNIFSSNHGPELYGTEPWTFYFKNLALNFNLWFVLALAALPLFILQKIISPSGQGFQTGLRTVVFLSPFYMWLAIFSAQPHKEERFMYPAYPFLALNAAISLHMILTALGNSDPKSLVGKIPAKLKLLIVTLTIILSIDVALFRVYGIWSAYSGPMKIYSPLWDGTDDKEPFGREEDTVCFGKEWYRFPSSYFLPRDMHAKFVRSEFRGLLPGEFAEAETGFGFWSGTWLPTAGMNDHNEEDLGKYTELPACAFLVDTQYPERNDPLPPNEPDYIADEKNWEIVKCEPFLDAAKTHMLARTLWVPDASFIPDKFKRKWGRHCLLQRKKAAEPAAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSD9</accession>
    <name>S0DSD9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427452.1">
        <property type="nucleotide sequence ID" value="XM_023574023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSD9"/>
    <dbReference type="STRING" id="1279085.S0DSD9"/>
    <dbReference type="GeneID" id="35395790"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02308"/>
    <dbReference type="HOGENOM" id="CLU_027371_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="439" mass="48332" checksum="58E2A42E1E84A5F4" modified="2013-09-18" version="1">MDNSLSPSEPRISHLDDYCSQAIDNRQPPESPSLKQLSSGGVADVSTSTSSSSPSSLTSGRPRRRPIPRKGHTKSRRGCFSCKRRRVKCQETTPSCDNCNRLGLRCEYPQTSDKALITLFSPQPAQAISQAQFSMVDLRFFHHFLLHAYPGLPIQGEEVWKEVAKYSHGFDYLAHAMLAVGASHLGLCNGTDYNSDAISHRVQAIKSLNSALSAPCQTKEEGDAQYATLMALTWQSSYMTDGMQEFLSMLRGCTIVFKSSVFQFEDSLFRMFSTEGHVQRVNDINNGFDKGLSDHEAIDAGIASIKAIAPLGQSTLEIGLVANLQNILEMSRSTCVGAFGAICRAYQLFGGASASDYLTISDSENHVAQIIMAHFFAIEYVLASIALAPVSPSFPFRKTIITAWLHRVKQKVPASYEAYTRWPLEFTSKGTSDWGIKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSE1</accession>
    <name>S0DSE1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427436.1">
        <property type="nucleotide sequence ID" value="XM_023574003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSE1"/>
    <dbReference type="GeneID" id="35395773"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02291"/>
    <dbReference type="HOGENOM" id="CLU_1981780_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495124" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14107" checksum="EEB823833D5DD93D" modified="2013-09-18" version="1">MLFNAFTTTAIAVCSLLAVPALANPIDTLPAGLDSHLESRANDITVKFWTTTTCRTSRSRKGYNSGYCIKDLASKDHAVSMQERKRTSCHMIRYREGNCQGYSEKGLNLNDCFNIGDDWKSLKFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSG2</accession>
    <name>S0DSG2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426413.1">
        <property type="nucleotide sequence ID" value="XM_023572256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSG2"/>
    <dbReference type="STRING" id="1279085.S0DSG2"/>
    <dbReference type="GeneID" id="35397937"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04456"/>
    <dbReference type="HOGENOM" id="CLU_135754_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT64332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="123" mass="13698" checksum="B7E9E8A6F722C620" modified="2013-09-18" version="1">MASQADYKDRQFLAVIGDEDSVTGLLLAGIGHVTTGADAQKNFLVVDGKTDTAAIESAFDRFTEDRKDIGIVLINQHIADRIRHRIDTYTAAFPAVLEIPSKDHPYDPEKDSVLRRVRRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT11</accession>
    <name>S0DT11_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">High mobility group protein I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427810.1">
        <property type="nucleotide sequence ID" value="XM_023574463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DT11"/>
    <dbReference type="STRING" id="1279085.S0DT11"/>
    <dbReference type="GeneID" id="35396181"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02699"/>
    <dbReference type="HOGENOM" id="CLU_128368_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16126" checksum="DE32EDF1BFE00C44" modified="2013-09-18" version="1">MARTKEDVASKDDASPRIPKSSSGVTKNTAEAPVKRGRGRPPKGAAPMPKKVYVPTGRPRGRPPGSGKKTAAGPKKVAAVNDDGTPKQGRGRPPRAARGTESAATTPKDGKKRGRKPKAADVSEDEEPNHDEPADEDDAVNESPAKDEDGEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT53</accession>
    <name>S0DT53_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable Metacaspase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426633.1">
        <property type="nucleotide sequence ID" value="XM_023572525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DT53"/>
    <dbReference type="STRING" id="1279085.S0DT53"/>
    <dbReference type="GeneID" id="35397697"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04216"/>
    <dbReference type="HOGENOM" id="CLU_029389_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="106"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="400" mass="43405" checksum="BE110DE5FEF0944F" modified="2013-09-18" version="1">MSYYPGQGYHGGGGGGGYGYAPPPGPPPPQQEYGGYSGGHSGGQRYPPPSYPPPPGLDAYGYRLPQGQHHYAEHARAGPPPPSTPQQFGHGAPEGYTFQYSNCTGRRKALLIGINYFNQEGELRGCINDVHNVSAFLVERYGYKREDMVILTDDQSNPAMIPTRENMIRAMGWLVSNAQPNDALFLHYSGHGGQVEDLDGDEDDGYDECIYPVDHTEAGPIIDDEIHFRVVKPLVQGVRLTAIFDSCHSATVMDLPYVYSTKGVLKEPNLAKEAASGLFDAFRAYSSGDLAGAAGSVFGLAKTAFRGDDAYEKTKDTRTSPADVIMWSGSKDDQTSADATINAQATGAMSWAFISAIKANPKQSYVELLNSVRDILETKYTQKPQLSSSHPIDTDLLFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU82</accession>
    <name>S0DU82_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428092.1">
        <property type="nucleotide sequence ID" value="XM_023574802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU82"/>
    <dbReference type="GeneID" id="35396486"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03004"/>
    <dbReference type="HOGENOM" id="CLU_053359_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="189"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="313" mass="34516" checksum="B8E76B427D32FC1A" modified="2013-09-18" version="1">MHVVDYLSRRPYGDGLCGVWETAGPLFDIQTLASERSSESRVLFWLSSSSFFFSRFFSNARERAESMAGPSPTHLSPRTAGSPILPPNSSLKPSPVNEDSSADEATGFISHTPPLNYNSLNVTSTATSAPQIRKPSLRQRPSSQQNNGAAQNPETTRQANSESGNTSWWQTQAEKFQSIELENKGSVARDHLAIERTFLAWLRTSLSFASIGIAVTQLFRLNTSLESEHGNNSQSNTQTLRHMGKPLGTTFLGISILILFLGYKRYFQSQHWVMQGKFPASRGTIMIVAFVALAIMVVSLVVVIAIHPSEHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUC2</accession>
    <name>S0DUC2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="12">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_04652</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="12"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426234.1">
        <property type="nucleotide sequence ID" value="XM_023572036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUC2"/>
    <dbReference type="STRING" id="1279085.S0DUC2"/>
    <dbReference type="GeneID" id="35398133"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04652"/>
    <dbReference type="HOGENOM" id="CLU_031730_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF17">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495183" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="14">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="15">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="237"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT64153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="339" mass="35115" checksum="4CB2C6127806C5E0" modified="2013-09-18" version="1">MRFSASAAALAMATTVSAHAQVYGLWVNGEDQGDGRNVYIRSPASNSPVKDLTSPDLVCNVNGGKAAPKFVKAASGDELTFEWYHDNRGDDIIDGSHRGPIITYIAPYTENDGTGAIWTKIAEDGYDGSEWAVDKLIKAKGKSTFTLPSALKAGKYIVRQEIIAHHESDVAYASNPARGAQFYPSCAQVEVTGSGTAVPDEKFDFNKGYTSTDKGIVFNLYGSYTTYDIPGPAVWKGTSSGSGSGSGSTPETPAATSAAAEAPAATSAAAEAPAATQPAGGNAGSETQAPAPTPTFATVVRPSEGASAPTEAPSAPVTPPKTGCSSKRRRARRAARRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUF7</accession>
    <name>S0DUF7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C6 zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_03707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427103.1">
        <property type="nucleotide sequence ID" value="XM_023573091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUF7"/>
    <dbReference type="GeneID" id="35397188"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03707"/>
    <dbReference type="HOGENOM" id="CLU_011409_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT65022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55792" checksum="C8E9A24E46793837" modified="2013-09-18" version="1">MVDFLSKVATVGSPQEVRSYRFFLEVTAPSLAGAFYADFWLTEVPRVCMSDAAIWHAVVSLGSAHEDFTEHGQGSRSMFALEQFNAAIRSLTDSRSPRYADRWRALIVSTIFTYVCTIKGLHDQTRLHLQAGRNLLHEVQGVAKKCRTASRETQIQEAIQDEAWISSVPVSIAPIQSILVTLELQLNALDHGGMTESPNLLLRSKTLNTWRYYTAPRPSHRLTPDTVNQAHCAAESLFSGLILFSQEHAMQLGDMQTRKSGPAGLSLLAAQQESHTRCYKEIRKAINVFENKIARSDNTPGHENQGELHTLLPLHLFQAANRLLLIQDPDDNNRSKREIDLPALYSSIVDLAEQIMNLDPAKTRRVTYTQHLFLVAHSGIGQSTRRRAVALLRRPRLEGGWDSLISASLAEAIMDREREAACEYQVEQHPDAATTGEEEKREPVEEEEGEEVNPMFRIFNITFVFTGPREARVVLRTWREKLEDVAGRTRVIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUI5</accession>
    <name>S0DUI5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NWD NACHT-NTPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426299.1">
        <property type="nucleotide sequence ID" value="XM_023572113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUI5"/>
    <dbReference type="STRING" id="1279085.S0DUI5"/>
    <dbReference type="GeneID" id="35398065"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04584"/>
    <dbReference type="HOGENOM" id="CLU_049618_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NWD NACHT-NTPase N-terminal" evidence="2">
        <location>
            <begin position="82"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="341" mass="37618" checksum="3B485A9B9D4F2A32" modified="2013-09-18" version="1">MKTASQPSAPHNAASKVKRLVGKIRRHSHPPSPEASSASPSSSANPSRESSSCPIPHIGKHSQRQSRRGSASDEEDRAHDLELWNAAYDVLKRDGTSSGLVLAYESIISHALPDTLRPGHNGNGNGLPTESERRAELMMMIAKSGLNREVKETSQTDSGDVEARENLIRTRSTIASLLDDQPSAAVAWAGFCSLTPLLLEPLLRHEDIRQGFVHIAHTIPHYMTLHRALHPSSWTSLPEFQRQQPQVHQTLLTLYRRILEYEMNIVCAAASAWNMAARNVVDWHGWKGMADAVRDMDAELMGYVEKNGTDEARALMEVQRKLEPEGGGRGELHDDTSSPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUN6</accession>
    <name>S0DUN6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="3 9">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_03140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="3 9"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428221.1">
        <property type="nucleotide sequence ID" value="XM_023574954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUN6"/>
    <dbReference type="STRING" id="1279085.S0DUN6"/>
    <dbReference type="GeneID" id="35396622"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03140"/>
    <dbReference type="HOGENOM" id="CLU_031304_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT66140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="476" mass="54442" checksum="34849BF0228ADADD" modified="2013-09-18" version="1">MSTPSLSDGQLTPTDTDPDLCFSSSEDDHVWPTPQDVVEMSIMLNGSAVPLSWTRESLKRLPIGTRPIKMVGEGAANVVFELNIPEGNMWGNDFKGWLLRVAKAPASGQPARFNYLKQQEFYAKQITPFLKTHAIQQRLVVLRHTNIIPQLNAFLRSIDHLRKEKFRGSFISESNWGLLVEDMRVSETKNSILIEFKPKWLNQSPSAPQGAIRCRQCAMELFNFLRDPSPSRHRPEQKPCPLTLANPDAPAEISSPFRFAPKLAAQANNPMVRELLAKTADHQVIRDLRWLQNLSDTRGPLRAEKGDPMFSLAMTVRDCTCFVQMNLGHDVPPEQRLRVRLGDFDLKDTDIKFKRWTSAEKDLIDSGCYTADWIMCNGQYYHPPTKCLLEWTRRRDRFVKIIGIKDKDPYLHPLPNKTAHFPTETMTKQALVYWMTTHPIKLTGLLEPGRKDKPKAEVCPFRNEPPDLMKWLSARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUR9</accession>
    <name>S0DUR9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to laccase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_04510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426364.1">
        <property type="nucleotide sequence ID" value="XM_023572194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUR9"/>
    <dbReference type="STRING" id="1279085.S0DUR9"/>
    <dbReference type="GeneID" id="35397991"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04510"/>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495202" evidence="7">
        <location>
            <begin position="21"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="71"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="196"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="417"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT64283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="571" mass="63634" checksum="DB7873A1F3CA35B0" modified="2013-09-18" version="1">MSRLSSISLIALASPLTALPEPINSKFQNQGSCSGNTPTTRDQWCGFDIHSDYYSVVPDTGVTREYWLEISEITFAPDGVPRFAQAINGTIPGPTIFADWGDNVVVHMTSNLKTSSNGSSFHFHGTHQNYTNPHDGVVAITQCPVAPGSSVTYRWRANQYGTSWYHSHFGLQTYDGVYGGLIIRGPASANYDEDVGTIMLSDWSHKTVNQLLHDVQREGPALMDNVLINGTNVYGNDTDKNQTGERFRLDFEEGKTYRLRLINTGIDTLYKFSIDHHTLKVIAVDFVSVEPYETDHISLAIGERMDILVTANRASRASSFWLRAIPQLDCTRNVNPQNALGIVSYASNSTTPTTKGRKHEDHCQDEPYESIVPVVPRNVGPPEMEVIQNANRSWNSDGIIKWALNSTTMIAEWGEPSLLKLNNSASFTKSNAVIRVPKKDVWVYLAIETEQDISHPIHLHGFDFQILAQGPGPYDSNVTLNTENPPRRDTALLPAKGHLVIAFLTDNPGVWLMHCHIGWHAAEGFSLQFIVREDEIPSLVSDQEYKDIEEGCKAWNGFSHKMKMEQDDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVD4</accession>
    <name>S0DVD4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to tetracycline resistance protein from transposon Tn4351/Tn4400</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_02303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427448.1">
        <property type="nucleotide sequence ID" value="XM_023574017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVD4"/>
    <dbReference type="STRING" id="1279085.S0DVD4"/>
    <dbReference type="GeneID" id="35395785"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02303"/>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="401" mass="44611" checksum="2CDAEC1B06105F0A" modified="2013-09-18" version="1">MPTKAPIAIIGAGPSGLTLARLLEINSIDYIVYERESPEPKFTNQGGTLDIHASSGHLALKEARLFDKFKSLARWDASRVFLQNPVGTVKAVFGEDRDAPEINRLQLRKLLLDSIPPQKIRWAHGVKSVEKGEKAVKHLIHFSNGTSASGFGLIVGADGAWSKVRPLLNSAIPDYSGKVFIEGSISHNNPSYTAALEHAGPGNMLAMGQHKIVAVQQLADRSYRFYMGMDAPEELYRRPLSHEDTEDIRQKLLSSPEFFADWAPKLREYLTNAEGPFHAWPLYRLPAWSVIWERVPGATLLGDAAHLATPLVGEGVNMAMLDALMLAKAIIKYCKNTSGADTEDSELESALTEYEEEMFERGQDYIRRCMAREAEFFSENAAEDFINMINRAKYNAEEDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVT8</accession>
    <name>S0DVT8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426684.1">
        <property type="nucleotide sequence ID" value="XM_023572588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVT8"/>
    <dbReference type="GeneID" id="35397641"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04160"/>
    <dbReference type="HOGENOM" id="CLU_1204807_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="230" mass="25614" checksum="6132C11198312683" modified="2013-09-18" version="1">MAAKNQSGQPSYEPLPREDPAAALLSPSEREDRDDGKTPVFRLSFSPILLLRLMIVPIVITDVVFICMPRSSPGSTAAFAMGGIFLVMWHASRVFKSLLPGRKSNKFDLKIGNFFCTIGTTSLASRTSRGAWTYLVSAIDFSFGLFFIGPSVLSFTAYNWYYEDNVSGLSLTVVIMQSAIAVLNLISLFRKMKIVVYRGEDDEDYLYSIPDLDVFRDEVSEPRDSMASEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWR1</accession>
    <name>S0DWR1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_02815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427918.1">
        <property type="nucleotide sequence ID" value="XM_023574591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWR1"/>
    <dbReference type="STRING" id="1279085.S0DWR1"/>
    <dbReference type="GeneID" id="35396297"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02815"/>
    <dbReference type="HOGENOM" id="CLU_008720_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="697"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="723"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT65837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="762" mass="85545" checksum="40625CEF0A67CED3" modified="2013-09-18" version="1">MPKPRTRRGAGREEKKRKRIEEAEQPYETYESENKRQRTYEDNDNTDGLDYQDGQDPQQNGLGEKEFFGMLAEEEQEYFRRADELLELNQFPSTEDRDIFLENVWKEAEGKELKLASSQSCSRLMERLIQLSNTAQKKRLFEAFGGHFLSLVQHRFASHCCEALFLRSAGVVSQELSGYVLDTKGADVDMQKPEASMENLFLATLDELEGALSYLITDRFASHTLRVLLLVLAGRPLEDASVRSLVKSKKKEKISVAGGSATDEANQGLRAVPESFSMAAKKIIQDSTAGMDATALRVLARHPIGNPTLQLLLELDLTLNKTEQKAESEQPTLLFQLLPGAPKSLSDGASEASEFINGMIYDQIGSRLIETLITHCPGKVFKALNQNIFLPRIEGYVRNDVSCYAAIRVLNRLSKDDLVQAVEKITPNVPQLVAKSRLNVLKTLFERCNARGANDEIKKLNKGLKEGCGNTPADLVIFLCGLKDEEKKKKDVQQLSKNEYAIQSHGAQLLTTLLSIPGPTKGVQESLLALEPQTLVRLATTSMPTVTVLTTALATSSSNPAFHKSIASAILPHTHELAISQFGHNLINAIVEVPSKGKERSIPFHMKEAFMARLGDHEAELRDSWMGRSVWRNWKGDMWKTRRGDWKLWMREVDANVPSSLPQRGSKVAEREKPPVKTVPEIVEDHHDQDPAAEVHITEDKMKMDVDDVVEAAVNSEEEESKKNKKDKTKKSKKEKKEKKDKKKKKKKDKSVEAKTDEETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX85</accession>
    <name>S0DX85_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable dopamine-responsive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427149.1">
        <property type="nucleotide sequence ID" value="XM_023571626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX85"/>
    <dbReference type="STRING" id="1279085.S0DX85"/>
    <dbReference type="GeneID" id="35398499"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05018"/>
    <dbReference type="HOGENOM" id="CLU_017452_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="369" mass="40229" checksum="4738EE4103D81F0D" modified="2013-09-18" version="1">MDFDDDAPPELVDTTTNDVDEEITVKVPITIVTGYLGAGKTTLLNYILTAQHGKKIAVIMNEFGDSLDIEKSLTVNKGGEQVEEWLEVGNGCICCSVKDTGVNAIESLMSKKGAFDYILLETTGLADPGNLAPLFWVDDGLGSTIYLDGIVTLVDAKNILRSLDDPNGVVEGHDDHSHGPVMTTAHVQISHADVIVINKADMVTETELSRVKARIQSINGLAKIHVTERSVVPQLEGFLLDLHAYDQFNESDANAKGHSHLDPTISTVTIPVGRLESGQLDTVDRWLRSVLWDSKLPEEEKESDFEIHRSKGRLVFANGEVKMLQGVREVFEINDGPLGDETPKEGKIILIGRNVAGVGFEDSFKKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY10</accession>
    <name>S0DY10_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429520.1">
        <property type="nucleotide sequence ID" value="XM_023576359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY10"/>
    <dbReference type="STRING" id="1279085.S0DY10"/>
    <dbReference type="GeneID" id="35407104"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13650"/>
    <dbReference type="HOGENOM" id="CLU_026944_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF3">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G06020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="747" mass="82730" checksum="720B23186C6C61D8" modified="2013-09-18" version="1">MTLPFVEVSHLAQSSSFYSATLQLIGLRFLNESREQNSSIGTITYGIPAGAGKSGGKRGDDQRGGTPVLQIREVSRPFEPVKLSTLVFAVPSTDAVIGFHDCAFTANPWLSIQTDGDPIYPGGPSPRPRLGFEGGQIPRRATVRDLDGNTIQVVYQQPACPRDYFGRIIEWTYDGTTAQSNRNRSLSQPQLQPIASARSSSSSINGQSPFQPRQSPAKHGPNTVTAAEMTQRAASRADEDEPVSVSPRQSSNNNGLSTTTVVGAILGVAAAGAALTYGFASHNAKERERKPRQEYEPPSLPRRSTFPEKAPTVHKLHNDERRITYADYPPTASQYPPKALPYRGHGGFAPQDMYPEGYPFQKHMQNDYAPRKMHHESYPPRNLGYIEDDSSEDSPDEPVRPIQYLTQAPYDEENPWSNESRARSRSRTRSVAKSAARSVAAKSTARSVAPSRARSRSRAPEEGYDTTRSRRSSRHPPPEDAYEFVETRSRHASRAPDDGFETRSRRASRPPPEDGFDTRSRRSSRPPEDGFETRSRRSSRPPITDKSRSVRARSEAGVSRSKSVVLVDDLRSEAPVGRKYDDRRSHAGSRAPKSSQSVVRGHRPPYDDERTYFSARSRPSSRAPRRSSRTEVEADIMEAPEVPEVPDAPEIPLDPDVYEAPDVPEMMPRSRARSRYNVPRMATGPDYPHMGYPSKAQSYVSARNVSLPMSGIGSSHADWDDDMVSVAPSDSISCVGVKPSRRSRKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYQ5</accession>
    <name>S0DYQ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429800.1">
        <property type="nucleotide sequence ID" value="XM_023576679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYQ5"/>
    <dbReference type="GeneID" id="35408094"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14714"/>
    <dbReference type="HOGENOM" id="CLU_894406_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="318" mass="36570" checksum="35A59EF86A7D1F6E" modified="2013-09-18" version="1">MDDLNTRRHFLLEELAEIDDTIAVYRQLAGDNGDVVNADTVDPTLPSRGDDYEDNYENSNNHIEDDRQIAFDFDGEMMEIFPEGPGSSSLTSDDDSVEIITSSPQEPSKLSLRDTPLVIFDRGPSQDPRFKPDQWLSEKPNESFSRDFLQGIGTQRLCNTLRPEISVIMLAHPYAEGCPANKACHHWELRWDDRPRRDPGTLELELICLDRRDRGDYIDPPGKKFYMLDKDHPRPIKCNPCFLFNGLKPDFSSLDGTNLDVVLFRMLQPDDGEDDDPVEGRDESEENNLDYPFEKIGWTECHRYMDRCGRQLATVLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYQ7</accession>
    <name>S0DYQ7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to calcium-independent phospholipase A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_02544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427669.1">
        <property type="nucleotide sequence ID" value="XM_023574288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYQ7"/>
    <dbReference type="STRING" id="1279085.S0DYQ7"/>
    <dbReference type="GeneID" id="35396026"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02544"/>
    <dbReference type="HOGENOM" id="CLU_429624_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="293"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="297"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="338"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="503"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="637" mass="70864" checksum="E272EFFABF37CEAD" modified="2013-09-18" version="1">MASYSSRTIHSLTGGINATDQASADIVALHGLGGDWNRTWSSFGYCWLKHALIPKFPSCRILSLNYPDMLSILSAHPPDINGLIHDIIRDRRQGNRSKSPIIFLGHSFGGTILKQVYVATHPSNTDDADYKALHGHIRGYVFFGTIHKDRDMSRAKLEVPEFWRALSRGASGTLGGHSHELEKAMYTTFRVNHAFRRLGGENLLINCFYETKGPGGLSGRVLITQEESTLVARPVPTMPLDLDHQSLVCFKSPRDENLARVLDALDSFMIRAMDVETRLHRPIAPESRGLCLLSLDGGGVKGLFSIIIIDRLMQETRRLEGPGAENKKPCDYFDLIGGTSTGGLLAIMLGRLQMDTQLCIQAYKSLSKEVFSRKFKVPFLESFRKASNVALSWPWFDGDKLKEAVCRTVKENLLPSDSAMLRQSGCTVEDLTLITDMKSATYSFVCAVPKYEEKVKRIRSYEPLDQQANAPAERFKIWEAARATSAAPMYFPHIEAGGVSYFDGGLESNNPVIEVIEEAKQEFPDDKISTVISVGTGAYQASDASAGLAGFMNYMINMATSTEKHHRAVLEDPRFADIRKEGYFRLNGTLELGAIDLAAVERMDEIERLAEVYLSSNEGQQQIGMCAERLVERARHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ41</accession>
    <name>S0DZ41_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429935.1">
        <property type="nucleotide sequence ID" value="XM_023576557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ41"/>
    <dbReference type="GeneID" id="35407986"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14605"/>
    <dbReference type="HOGENOM" id="CLU_104282_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="75" mass="8551" checksum="A469DD3DE9FBD445" modified="2013-09-18" version="1">MKSDKVRQLDKAAVEGYPAGQIPRLKKNVPIYISRSTEKDKDKEFIAEVNLWSMGVRYNLNRLVGEGPQLYIVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZI8</accession>
    <name>S0DZI8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT67951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430031.1">
        <property type="nucleotide sequence ID" value="XM_023576869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZI8"/>
    <dbReference type="STRING" id="1279085.S0DZI8"/>
    <dbReference type="GeneID" id="35400178"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06701"/>
    <dbReference type="HOGENOM" id="CLU_1147238_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="279" mass="31096" checksum="FF28B8A042FC743D" modified="2013-09-18" version="1">MGEGGSMAVDSIRNRLGVDAFNTLSISSNPFREQWYSMDQRALPQSAEGGILPSVYRQSEFLFNDSMPTSPTSSLDRLSDPYPAATFTATLTVFQTPFPQTSHQLGILSPPLTTKKEERQKQKRCSNKSSARKSLRQDSSRDSKANTATGGGGTGHSNRPCGTHGHHGTEHSDQQGKKHSQYTKESNRIASSKFRAKKREYMLRVQSEEQEMERTNHDLSVCVANLTREVQELKMKLLQHNDCDCSLIHDYLATEAQRYVCGLSKQSQLEAISPGAAWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZM9</accession>
    <name>S0DZM9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_02924</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428019.1">
        <property type="nucleotide sequence ID" value="XM_023574712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZM9"/>
    <dbReference type="STRING" id="1279085.S0DZM9"/>
    <dbReference type="GeneID" id="35396406"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02924"/>
    <dbReference type="HOGENOM" id="CLU_000288_127_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903329">
        <property type="term" value="P:regulation of iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="219"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT65938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="502" mass="55344" checksum="2FDF98834B511E25" modified="2013-09-18" version="1">MPTASGSSKPPSASSSKPSSVKSQDGVKKSPGLAPQNGATTDNGHPPLDTHLKPTASVKNRLTRMFSSKDTSRVPTPAASTVDLPNRPRASSTNGTSTPAAKASSTEKGSDKVSLKTTDKATTPAKPATKSTSGKEPSQRFVLNPEAQGGHEHHLKSSRRQEKLSDMWRAIIGKKQDAAAEHDLSLVSNWVDTLQQEKEEAGDRKGGPSATTTLVEKYGKCQEVVGRGAFGIVRISHKKIGGSNEKLFAVKEFRRRPEETEKKYSKRLTAEFCISSSLRHPNVIHTLDLLKDAKGDYCEVMEFCAGGDLYTLVLSSGKLEVQEADCFFKQMMRGVEYLHEMGVAHRDLKPENLLLTTRGALKITDFGNGECFRMAWETDAHMVSGLCGSAPYIAPEEYTDKEFDARAVDVWACGVIFMAMRTGRHLWRLAKKDDDEFYARYLEGRRDEEGYGPIESLHRARCRNVIYSVLDPHPTRRLTAAQVLKSEWVREIKLCKAGEEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZQ7</accession>
    <name>S0DZQ7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430139.1">
        <property type="nucleotide sequence ID" value="XM_023576997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZQ7"/>
    <dbReference type="GeneID" id="35400292"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06815"/>
    <dbReference type="HOGENOM" id="CLU_1402543_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="194" mass="21312" checksum="31B4E3C1800B8295" modified="2013-09-18" version="1">MNLSIDTAENLQTLRLSILKRVSLLDQYIKNTKSFVSHQPDDGSDPATTSATELQKLAWGIIVSADNFMNVVLGIKSRFSSRSSLVDTVEIEDSIKSATDVGVAQEKKNVRFALADTSTRHSIQTIRSEIIPKSQNKVENGTSQGSTLGSSDPEIPALSRPQKGHFSLAEIVKYLTHNDDKAKTDQLESTFFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZU0</accession>
    <name>S0DZU0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to heterokaryon incompatibility protein (Het-6OR allele)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430199.1">
        <property type="nucleotide sequence ID" value="XM_023577074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZU0"/>
    <dbReference type="STRING" id="1279085.S0DZU0"/>
    <dbReference type="GeneID" id="35400360"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06883"/>
    <dbReference type="HOGENOM" id="CLU_004184_7_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="156"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="736" mass="82399" checksum="247643142F9D364B" modified="2013-09-18" version="1">MLPSKPKAEAKSSARHSRDSCSSFKVPAALRASSLLSRMNPSLRASSIESYLGGLVSNRLIFDRDSDSRIPLPLFADLEQDSNVEGILLSINNPRSPICRFTPLENNGTPAKSTSGIYHPLPGASTFRVLEILAGEDDVVQCKLHVCSLQTNEAAYEALSYTWGTSGTSSHRKIEIISNGASHSMSISVSLYIALRELRRSNTSRVIWADAICINQEDVKERGQQVVLMGQIFSGAWQVVVWLGEESDRCMCGNTVLETSLSSVSKAFSGVCAVVNDWLAQAGQEALEATYSELSKYDDSTVYRANINDGEDSRSYMMQLFRRRWFSRMWVLQEAVLARHALVQLGSYQIPWEWVGLAAAILVHKPELSPSGFGRDMIPTGAMNGYLMYRLSVSQKCFPRLEFSFAQLLQVSRYFQSKEPKDKVYGLLGIETTDSVGRQIVPDYRETINSEKVFEDIARLMLESANPLTFLSGAGTFGDYDRSRPSWVPSWHKRRPWTILPTKQDQGFQCASASRMEMRSDHKEGELVLKGVIVDQITSMQEHRDYWGIFDENDKSRNNLLNQPRWSTEAWRKCAMILTCGGDGRAYPIDDEATNLADLAAVVLSRSAHWVIRDLIALRDVIEPEDDEMTQAEYLAEIAEGGNARRYISAVEPVRNSYRLFKTASKDFGVGPVDMKIGDKLCVLFGAEVPFLLRPKGDGYLVIGECYVYNLMHGEILEKLTADPEGQLKAEWIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZZ3</accession>
    <name>S0DZZ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT67970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430050.1">
        <property type="nucleotide sequence ID" value="XM_023576891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZZ3"/>
    <dbReference type="STRING" id="1279085.S0DZZ3"/>
    <dbReference type="GeneID" id="35400198"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06721"/>
    <dbReference type="HOGENOM" id="CLU_048766_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="453" mass="52012" checksum="D4A38C63CDF23F11" modified="2013-09-18" version="1">MSSATDIQSLPSEVLRNILFFVRNEKNGQCSIKECRLVSHYFNNAASPLLLTQVSVCLTSKSFNRLEDICNHPVFSKSVQSVRIVTSYYEAELACNRPLFMLEAKARLLRHVETMQRSRSYRNKYPLTQEQSRWLSNMAWRTEPEFEQLFSDQVDEESPTPTQRLFLKLYDMYKELYNDQQQIREGRSHITRLCVALSSLSNLVSFELSDIRNMGGMENLDASDFAHTGYDHTILQHFSPILRKSRWCGSFKTIHTATPPVEMIGTLCSELADKGLRPEIIRLRLVPPPSMQAWQLSPSQQSGVKKLVAQTTKLALYVDFQARSYELKNNPKNEMLALCSITQSWMSAPHLEDMHVEFIGYPPLNIRPTVSLDDILPANLSWPRLRSLSLHNQPFTVMELKYLVARHSETLRDLDLQACWLADGSWDDVKEAVQNQQELERSSIKYPAGGNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E073</accession>
    <name>S0E073_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to pyridoxine 4-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430296.1">
        <property type="nucleotide sequence ID" value="XM_023577189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E073"/>
    <dbReference type="STRING" id="1279085.S0E073"/>
    <dbReference type="GeneID" id="35400464"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06987"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF7">
        <property type="entry name" value="REDUCTASE (YAKC), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="327" mass="36193" checksum="F2F3EE58381C2AEE" modified="2013-09-18" version="1">MVKEIQFGDITVPSPGFGAMGISFGLGSNLSLEEAEPVLLKAIELGCTFWDTAVVYQAGVNEKLLGDFIRKHNVRDKVFIASKCGFDVFGKGGVTNSASHIKEYIEGTIERLGFAPDLYYLHRIDPNTPLEESIPALDEIRKQGKTKYIGLSECSAKTLRKANSIAKIDAVQAEYSAFETLHETDGLIDTAKELGIAYVAYSPLGHGWLVDDFPYKSPDDFAPDDFRRTVPKFQGENFYKNKAIVEEIKKLAVRKGCTLTQIALAWVASQGMIAIPGTTKAHRLEENWASRNVDLTEEEKAEMRRIIDSAKPQGNRYSATHQAMVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0E1</accession>
    <name>S0E0E1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430356.1">
        <property type="nucleotide sequence ID" value="XM_023577258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0E1"/>
    <dbReference type="STRING" id="1279085.S0E0E1"/>
    <dbReference type="GeneID" id="35400526"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07049"/>
    <dbReference type="HOGENOM" id="CLU_065647_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="2">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="324" mass="36484" checksum="BD7F4EEF874CB1FA" modified="2013-09-18" version="1">MSSSSSTSPQATSQGETMAPRRLADYIERIEVDKTSSQTTTRPFNNGTATQPPVIRGRVNRILLFPGSFNPPHQGHIDLLKHVFYNGGADLNIIAAIIITTDDERLAMKMDGRETDVVLSREKRVNLWRGDGIPVDWAWVYDNSEASWPGFRAKLVNALKRDGVDLKFTLLLGPDAITADGGYNPVGWNCGDAITSDISRPVDFRYPNSLRQLAGCTPWVNLQDGRSRFANRISICRQNRVRPRGTIRFVPCDLDRRPQDAPSSTKIRKIIERSPQEEWEEKLKGIALHPKLLVEYLKELPPPTKPAAESKEDLAKKQWESIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0J2</accession>
    <name>S0E0J2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase kappa 1</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GST class-kappa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_03238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 10">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428309.1">
        <property type="nucleotide sequence ID" value="XM_023575063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0J2"/>
    <dbReference type="STRING" id="1279085.S0E0J2"/>
    <dbReference type="GeneID" id="35396720"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03238"/>
    <dbReference type="HOGENOM" id="CLU_069253_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="7">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00083519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT66228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="226" mass="25238" checksum="6BDD174967B84620" modified="2013-09-18" version="1">MGGRIDCYLDIVSFYSYVGYADLRQNMSKLAAHGVQVNFIPVFLGGIMQTSGNRPPWVLKAKGKYLARDSFRAAERLGVPYQGSPPDIVAIAKTVSPLRALHFIKENYPESTYLAAIRYLFHKIWLPPHVNLAEDEKLIAALKEATDELDGGSGKKLFSDEDVEKIMNGRESMKERVKDLTGEAVQKGAFGAPWLVVTRDDGESEAFFGSDRQVVVVLKERKQRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0U4</accession>
    <name>S0E0U4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to DNA repair protein RAD26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_07180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430481.1">
        <property type="nucleotide sequence ID" value="XM_023577403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0U4"/>
    <dbReference type="STRING" id="1279085.S0E0U4"/>
    <dbReference type="GeneID" id="35400657"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07180"/>
    <dbReference type="HOGENOM" id="CLU_000315_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029256">
        <property type="entry name" value="Heliccase-ass-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057931">
        <property type="entry name" value="RHH_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25806">
        <property type="entry name" value="RHH_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14773">
        <property type="entry name" value="VIGSSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="187"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="555"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT68401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1030" mass="117337" checksum="4B214CC6421BEF3D" modified="2013-09-18" version="1">MPPAPSDVIEIPDDEGTFSESEGHTSSFTKTAGKRKHDTEADIEEKVEWTGDEEDLPAKPKKRRGGRKPTRKRKGDDIYGQAEVPKDDYELAGLPDYLIKRRRKFDTKRKLHHDNALMVPPDYSGIHFEETRRLRELEERPRFSESSGIKPSRPYQDIELPQSAGLIPASIAQYLRDYQVAGVSFLHRKFVYQEGGILGDDMGLGKTVQVAAFLAVAFGKTGDERDAKRLRQIRQYPDRWYPRILIICPGSLIVNWKNELDRWGWWHTDLFHGSHKDDALSTARAGLVEIMITTYDTYKNSRSSINIVQWDAVIADECHRLKDRYSETTKALNEINALCRLGLTGTAIQNRYEELWTLLDWTNPGHFGTLAEWTQRVTKPLTVGQSHDATKAQLSLARTTADKLVHNLLPQYFLRRMKSIIAKQLPKKTDRVVFCPLTDLQREAYENFLESADIDLLRSLSDPCCGDKKRGWCCDRLLSSGVRWQNIVFPSMIVLQKMANHLTLLVPQTTDLEGKHESDLNTLRTCLPEDWKYVYDNRDRIKNLVNPEFCGKWKVLKKLLKFWHSNGDKVLVFSHSVRLLRILQHLFTNTSYTVSYLDGSLSYEQRQEVVDTFNSDPTQFVFLISTKAGGVGLNITSANKVVIVDPHWNPSYDLQAQDRAYRIGQTRDVEVFRLISLGTVEEIVYARQIYKQQQANIGYTASSERRYFKGVQQDTDRKGEIFGLANIFTYHNDSGLLQEIVNKTNIAEAKAGVHLVDVNMEQAAKDGEDLAVVKNEETDAEDGGMSQLATLLTAENQQRMIESKKAKKPKSDAIQAILTSAGVEYTHDNSEVIGTSKVEEQLSRRAVMTTYSSGDVDGQSALFADSDDEQGDGLHSMYNPPEEVMLRHFCEMAREFGFRNATDFALVVESWSQEARRNCLDTFYKRRAAKLIQEGIIKEEDVKDTAQVDTKHDIDAKEEVKDEKKDVRLTLKEEDVKKDDTKHALVKTETTKLEAVDTKMEGEKKIKTEAQGSSIRTSIFLSDDDDDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1N4</accession>
    <name>S0E1N4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Manganese lipoxygenase</fullName>
            <ecNumber evidence="3">1.13.11.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_03607</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate</text>
            <dbReference type="Rhea" id="RHEA:18993"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:57467"/>
            <dbReference type="EC" id="1.13.11.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.13.11.45" evidence="3"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428649.1">
        <property type="nucleotide sequence ID" value="XM_023575474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1N4"/>
    <dbReference type="STRING" id="1279085.S0E1N4"/>
    <dbReference type="GeneID" id="35397089"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03607"/>
    <dbReference type="HOGENOM" id="CLU_004282_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050584">
        <property type="term" value="F:linoleate 11-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485498" description="Manganese lipoxygenase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="10">
        <location>
            <begin position="185"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT66568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="583" mass="64814" checksum="0172F4610A4EFCBB" modified="2013-09-18" version="1">MLFNIALLFNVAGAVAAVNGPKPFSLPSSKSPGRAAAIEKTRQGFQYGTDDTLIRVNPWPSGPLGKKAVKAHYSAFETSETPVYKHADEDTAQAQASLNGTLHLDSLEDYFKLYDGQWQKSVPDGLADGVLLNAKSDLSFSMERLSVHPESLRRVKPDERVALRVEDRLARKITTKTQRSLQREGRLFIVDHSDLANLTLTKGRYAGACEALFFIHPVSQEFLPLAIRPNNGSPLIYTPLDEENDWTLAKILLNSNDVWHNQWYHMAAAHISSDLIYMSATRSFSDMHPVWGLIRRLGVNSFAYRVGASASLVNPGGDIEKNFAWNGDQAIEYSKQLWRSECAPWRANYLEEKLTRRGLINCEYGPELKSFPYYEDASVILGALRTFITEYVNAYYPSDDAITADKELLAWFHEAADAADIVDFPASISTKSELVAVLSHHAYLISILHGSLNSNSLVHYSAVLPMHPLSLYRPLPEKKGISSLVPFLPDLEASIQHIALVATFNQAQIADTPDSLRFLFNEAEFYSRINKEARAAAKAYSATLSKFSKQVKGRKIRGDGRSQGMPFVWNVFDPSTGPGILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1S9</accession>
    <name>S0E1S9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430730.1">
        <property type="nucleotide sequence ID" value="XM_023577709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1S9"/>
    <dbReference type="STRING" id="1279085.S0E1S9"/>
    <dbReference type="GeneID" id="35400931"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07454"/>
    <dbReference type="HOGENOM" id="CLU_037529_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="350" mass="34846" checksum="93E746EF0A901181" modified="2013-09-18" version="1">MSGLINKVKDAIHSDKDKSHEHPTGDHRANHGTTTTGGLGSSTHNTGTAGGLTGGSTYSENMPGHTTGRTENLPGHTTAGGLGSHSSGLPEGTTGPHGSRLANAADPKVDSDLDGSRRVGGSNTYGQTATGTSGLSSHGAGAHGGIGGTSAGYSTGPGNTAGPHSSDMANKLDPKVDSDLDGSRRLGGSNTHGHQGGLGGSTGTYGQTTTGTSGFSSHGAGAHGPTGTHTGTHTGTHTGLGGTGSTGTYGSTAGTGPGPAPKTAGPHSSDMANKLDPRVDSDLDGSKTVGQEKTFQRSNNNFAGRDPTDATQVPPSVLQKHVPTEIAHDDPHSDHSRRHSSTHQETHRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S0E255</accession>
    <name>S0E255_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_07751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431004.1">
        <property type="nucleotide sequence ID" value="XM_023578038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E255"/>
    <dbReference type="GeneID" id="35401228"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07751"/>
    <dbReference type="HOGENOM" id="CLU_2812549_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="67" mass="7636" checksum="C1A54BEEF2452B71" modified="2013-09-18" version="1">MSKTAECVNQKPYSESSKERITDVALHGLKSLSEQDTPISMWLRHLDDPYPYSRRANANDGMPKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2F5</accession>
    <name>S0E2F5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429923.1">
        <property type="nucleotide sequence ID" value="XM_023576505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2F5"/>
    <dbReference type="GeneID" id="35407939"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14558"/>
    <dbReference type="HOGENOM" id="CLU_2223497_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="106" mass="11899" checksum="68C98AA2171D6ED3" modified="2013-09-18" version="1">MDSSYSFWPTLEVIWHRHMKASNDQYKPLSYRPAIILCPKAPKGDELILSPKMTKEYVDVGLIVGDVPEKHSRKGESEIPEITKGQGLDIKTLGKAPNSGICQYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2P2</accession>
    <name>S0E2P2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to integral membrane protein PTH11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_14875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430007.1">
        <property type="nucleotide sequence ID" value="XM_023576867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2P2"/>
    <dbReference type="STRING" id="1279085.S0E2P2"/>
    <dbReference type="GeneID" id="35408253"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14875"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF15">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="33"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="366" mass="39941" checksum="C242827FD7DCAE31" modified="2013-09-18" version="1">MAAAPTIEPRGLGLAQLITSILFGILTTVVVFLRTFIRVKNRVFGADDMLMLIGYILFAILVGVSSKSTYYGAGQRDSVLPEGIYPHGRFYVWLFQIFYCASLVFIKASICDALLRIAVIPWHRVVAWMTLAMAVICAMIVFISLFVLCKPLSATWNGDGKCSPPSALAILACFVSASSILTDIICAALPALMLYKAQMKLATKVSISMVLGLGALASVATIIRMPFVLFYFHPNPDYLYRHCHVSLWSTVEAGIGIIAGSLPALRKFVKRWITFDSSARQYSPPKPYGGSNGLGITSHIGTASRVKGYNISRDVENDGKDHWEGLDDGSSRRGIIVTVDVEMHALENNAESIGSRVSDETYARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E333</accession>
    <name>S0E333_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431145.1">
        <property type="nucleotide sequence ID" value="XM_023578318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E333"/>
    <dbReference type="GeneID" id="35401479"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08002"/>
    <dbReference type="HOGENOM" id="CLU_039184_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF24">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25973" checksum="5076679E209DF033" modified="2013-09-18" version="1">MAPTIVLIRHAQALHNVAHKSPFTQSLEYITDNGEEQCALLRENLISTFSDKVDNVDDVAIVVSPMRRTMQTAMLALGWLVERGVKIEGNADWQENSSKPCDTGSPLSSVSPSFPKVNLSSVDPLWPDKTSPAAERYWYTKKAILDRGQHALEGLKKRPEKLIFVVSHAGFLRLGVAGYWFFNSDYRVFDFEDEGIKQREATAAGGMGLSFTEPVELGLDLPEEDPGYDAEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0E373</accession>
    <name>S0E373_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">FFUJ_07875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E373"/>
    <dbReference type="SMR" id="S0E373"/>
    <dbReference type="STRING" id="1279085.S0E373"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07875"/>
    <dbReference type="HOGENOM" id="CLU_090154_1_0_1"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT69304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="176" mass="20771" checksum="6A8656717110AAF2" modified="2013-09-18" version="1">MRAYFYDGLPGDQRLPHNSGMPVSVDDLMNIGVYYYHLPELESVDNLAKERGYKNRDEITVSPQAMGDIYETKVKSFFAEHLHEDEEIRYIRGGRGYFDVRSKDDDWVRVLLEKDDLLILPPGIYHRFTTDESNYVHAMRLFKEDPKWTPLNRGPDVDKNEHRQEYVKQFLGEPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3Q9</accession>
    <name>S0E3Q9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to BolA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429429.1">
        <property type="nucleotide sequence ID" value="XM_023576254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3Q9"/>
    <dbReference type="STRING" id="1279085.S0E3Q9"/>
    <dbReference type="GeneID" id="35407009"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13555"/>
    <dbReference type="HOGENOM" id="CLU_109462_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071281">
        <property type="term" value="P:cellular response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="92" mass="10042" checksum="DD455AF5E062DEE2" modified="2013-09-18" version="1">MSQITDESLREAIKQRLEATHVEVTDMSGGCGQAFNSVIVSPQFQGLNSLKRHRLVNAALKDEIAIIHAWTAKCQTPEEYAKTSAANDTAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E486</accession>
    <name>S0E486_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431764.1">
        <property type="nucleotide sequence ID" value="XM_023578818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E486"/>
    <dbReference type="STRING" id="1279085.S0E486"/>
    <dbReference type="GeneID" id="35399069"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05590"/>
    <dbReference type="HOGENOM" id="CLU_009377_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="283"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="647" mass="71367" checksum="212F778C588E40E6" modified="2013-09-18" version="1">MEPGNANNGPAASDDSARRAIDQIEVRLGNIESLLRDLSQRPVSTPGSNIHFPVTPAAFPGLDPASASTAAFDSSDDESVLGGDSVIAQQTTFASDLLEHAVERTSLNDVSPKMWEALANLRQLAELQSRQSISHGPRFPLQQPIPKGGLGQLPMPPMDIVVSLLKRVRASPPGLFTFVCYFIGINDFSNLCRMVYFPTDDFSDSTFIIVNVGLYYLFLEQHHLTVDNKPLKDEFASHLYTSRVNLETALANMSLFMSTKIETVQALLMGTLYTIDVCRPSVAWHLNCAAAQICQTAGFHRRDLSTRNPEEADIKAILFWYTYTTDKALALRLGRAPAIQDWEITIPRTFGFDGILSLETKAVAGTWLNAATLQGQVYEQLFCPAALSQPPAVLAERARLLAAECRRVEAESFQSREMAISSLEKIGASPLVDVHLKGDEVQLLSTMTLIYRAVPAPEGSHTRFCQDCIDTARKACHAHFACMDLVRKDPHARAIYVHWNLVLTPFAPFFVLFGYVIETSSQDDLQLLKQFSASIEETSDASETMQKLSRLCSIMSNVAALYVEAKSQQVEDRTMVPINDEFDVYLSQLGLMPVMDSTMGNAGDPNAEFGENAQVNQMADWMSGSRNLLGLLEQDISQIGGVQWPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4M6</accession>
    <name>S0E4M6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430717.1">
        <property type="nucleotide sequence ID" value="XM_023577690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4M6"/>
    <dbReference type="STRING" id="1279085.S0E4M6"/>
    <dbReference type="GeneID" id="35400915"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07438"/>
    <dbReference type="HOGENOM" id="CLU_037990_2_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="279" mass="31494" checksum="721A994D78957420" modified="2013-09-18" version="1">MSPTESQSDAAQRMYTERATTYEDSWHPDYSKRFMELVPIKPGDRVLDLACGTGLKAVIAARHVGDDGIVVGVDITEAMLSEARKTLDRDETLHRRMKLVRHSVTDLTGCLNVDRDSFDLILCSNAFVLFESPEEVVAHWREYLKPGGRVAIDITHEYNLRSGLLLEKVARRLGMPFPSNRSWIKSKESFSRILGSCGFVVERVVTLEKIVGLGSTYFGLDKADEQFDYVVNGPLAASIITEELRVKGREYFKEEWHNAAVDGEVEVSDILYVYIARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4S5</accession>
    <name>S0E4S5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_14648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429749.1">
        <property type="nucleotide sequence ID" value="XM_023576605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4S5"/>
    <dbReference type="STRING" id="1279085.S0E4S5"/>
    <dbReference type="GeneID" id="35408028"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14648"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="501" mass="54273" checksum="A74FEB0498FE309B" modified="2013-09-18" version="1">MSLDVQLTAPNGRTYKQPTGLFINNEFVPSSSGKKITSINPTNEQEITSVYAASAEDVDKAVRAARRALRNPAWRDLPATERGKLMNRLAELVEENRDILATIETWDNGKPYSVSFNEDMTEVAETLRYYAGFADKVFGQVIETTGDKFGYTIREPIGVCGQIIPWNYPLAMAAWKLGPALACGNAVVLKPAEQTPLSILYFANLVVKAGFPPGVVNIVNGLGTVAGAALASHMDVDKIAFTGSTPTAKTIMKMASSNLKNITLETGGKSPLIVFDDADIDLAVYWAHAGIMSNQGQICTATSRILVQDGIYDKFLAAFRAQVKNISKVGDPFDEKTFQGPQVTKAQYDRILSFVEVGKKEGAKLELGGQPFKKVGDGKGYFIEPTVFTGVSPTMRVFQEEVFGPFVVVSKFSSEQEAIDLANDTQYGLGSALFTTNLTRAHQVAKRIEAGMVWINSSNDSDWRIPFGGVKQSGIGRELGEAGLAAYSNIKAVHVNIAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4X4</accession>
    <name>S0E4X4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable GTP-binding protein rac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_05727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431891.1">
        <property type="nucleotide sequence ID" value="XM_023578971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4X4"/>
    <dbReference type="STRING" id="1279085.S0E4X4"/>
    <dbReference type="GeneID" id="35399206"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05727"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="199" mass="22165" checksum="E637D123EAFBE93B" modified="2013-09-18" version="1">MAQPGVQSLKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSASVMVDGKPISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSIVSPPSFDNVKAKWYPEIDHHAPNIPIILVGTKLDLREDASTLESLRQKRMEPVSYEQALTCAKEIKAYKYLECSALTQRNLKSVFDEAIRAVLNPRPTPSKQKKNKCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E581</accession>
    <name>S0E581_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431935.1">
        <property type="nucleotide sequence ID" value="XM_023579024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E581"/>
    <dbReference type="STRING" id="1279085.S0E581"/>
    <dbReference type="GeneID" id="35399253"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05774"/>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485292" evidence="1">
        <location>
            <begin position="25"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="282" mass="30817" checksum="DE01E0B73F9E7345" modified="2013-09-18" version="1">MKFFQPIAVFLSLLTSIAPGGVLAAEESATAQHQKGETVRYQGLNLYVSKPGRFNLGHKKPGKRTGVLLLTDVYGIQLKENRELVDDFAKEGFFAVAPDLFRGDPAKETPGFNITEFLAKHPPSVTDPIVAKAINYLRNELEVNSVAATGYCYGGRYVFRSLGENGKVDVGFTAHPSLLATDEIEAVRKPVSIAGAGQFQPVIAIKEKTKADMDIAEDQIFPQPRQAETEAILTKLGKPFTSVLYSGTTHGFAVRANASNPQQVFAKDEAFYQAVRFFNAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5S0</accession>
    <name>S0E5S0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_07971</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431117.1">
        <property type="nucleotide sequence ID" value="XM_023578283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5S0"/>
    <dbReference type="STRING" id="1279085.S0E5S0"/>
    <dbReference type="GeneID" id="35401448"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07971"/>
    <dbReference type="HOGENOM" id="CLU_023360_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034202">
        <property type="term" value="F:glycolipid floppase activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RFT1"/>
    </dbReference>
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        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="96"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="167"/>
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            <end position="437"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="546" mass="59530" checksum="B84FE0EE69C88696" modified="2013-09-18" version="1">MIKGASLLIILQLASRLITFIANQLLLRYLTAPLLGLSTQLEVYYLSVLFFARESLRVAIQRRDSGSQAKEESQAVVNLGYLAIGLGSFVSLGLGWMYLAYANEITLATPYLVESLYLYGFAAMVELLSEPCFVLMQTRLQFGTRAAAESIATFLRCIVVFGSAVWASKHNDIGVLPFALGQITYGVSLLLVYLVSGYRLASSIGFSLLPKTITSKDNRFWASLFDQSTIGLAGSMMAQSVVKHLLTQGDTFLISFLASASVQGAYALANNYGSLLARLLFQPVEESSRSYFSRLLSSVTPVKQGGKPVQEVSEAKQNLQTLLRLYILLASIIISLGPFAAPPLLAIVAGKQWAGSGAGDVLAAYCFYIPFMGLNGLTESFVASVATEAEVHIQSVWMGAFSVIFAASAFLFMRIYPLGAIGLVLANIINMGCRIIWSGAFIKRFFRRHGTDFKIKSLIPESTLGVSIATAILLKQLKVVDNADQPIKSLVKIAGSAIPLLLLMYVYKIPKANFLKTTSNHRSLVLERHFILECLNSVRGRKAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E683</accession>
    <name>S0E683_GIBF5</name>
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        <submittedName>
            <fullName evidence="1">Related to decarboxylase DEC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT68043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000016800">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
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        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="248" mass="27900" checksum="153F5C28CFAFCB9E" modified="2013-09-18" version="1">MVFGSLSVQDDRAIPVFAPPYVSQEPFHFSNMTIVSISYRVQASQIQHLVPQELELEDQPIMTSLFIHYGTSTVGEYNEYVHTVRVKYNNDIYDYSLVLLLDNDSAIFAGREIFGYPKIFGKVNFHPSAGSRVMMGNAERPAGRSLIEFEFAPKALFDVPLGEATPPKVLNLRVIPSTDQAEPALREFVAVDMQFEFSERWSGEGSLKFNKGFASTPWADLDVVSYIGSWMGKSKVVLGNKVDRFPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6F2</accession>
    <name>S0E6F2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable transcriptional repressor rco-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_07891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023578194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6F2"/>
    <dbReference type="STRING" id="1279085.S0E6F2"/>
    <dbReference type="GeneID" id="35401368"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07891"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_23_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036033">
        <property type="term" value="F:mediator complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000879">
        <property type="term" value="P:negative regulation of dipeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042304">
        <property type="term" value="P:regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000111">
        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="395"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="481"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="534"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="576"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT69317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="613" mass="66088" checksum="078D82977C5FD512" modified="2013-09-18" version="1">MGGGPQGNSTRLNELLEQIRVEFDTQMRATENYEHQIAAQVSEMQLVREKVYQMEQTHLSLKQKYEDEISALRHQLEAARKGGIQPGIPGPPQHAAPSQQPPSIAPGNGLFSGIMAGGSQGGLVPPQPGQQQGQQGQPQGAQQQQQTQQGHAPPQEQPLGPQHQMGQGPPGLPVPPPHPNAQQAPYSQNYPPGPVSNGMGPQPQSTASPGPGRRGIGRPPGAVGPATPQVNTPVPYPGSAASPQVSHPTPEHGRMGGPHAPAVGNALGDLEVDSVAPHNKKTGQDWYAIFNPQVQRVLDVDLVHSLNHESVVCCVRFSHDGKYVATGCNRSAQIFDVQTGEKVCVLEDHNASDMSADLYIRSVCFSPDGRYLATGAEDKLIRVWDIQTRTIRNHFSGHEQDIYSLDFARDGRTIASGSGDRTVRLWDIEQGTNTLTLTIEDGVTTVAISPDTQFVAAGSLDKSVRVWDIHSGFLVERLEGPDGHKDSVYSVAFSPSGKDLVSGSLDRTIKMWELSAPRQGNQPGPKGGKCVKTFEGHRDFVLSVALTPEANWVLSGSKDRGVQFWDPRTGTTQLMLQGHKNSVISVAPSPQGRYFATGSGDMKARIWSYRPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6W6</accession>
    <name>S0E6W6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432625.1">
        <property type="nucleotide sequence ID" value="XM_023579859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6W6"/>
    <dbReference type="SMR" id="S0E6W6"/>
    <dbReference type="STRING" id="1279085.S0E6W6"/>
    <dbReference type="GeneID" id="35400002"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06525"/>
    <dbReference type="HOGENOM" id="CLU_1517996_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484923" evidence="1">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="149" mass="16470" checksum="40C751CFE5CA1AA0" modified="2013-09-18" version="1">MKFLPLAVALFATLTVAAPSSPSDIQARSCVCKKVGDDWICTGTKCYDKVKRDLVPRQCSCHKVGDEWLCGGPKCPRDLPEENKLEKRQCSCHKVGDEWLCGGPKCPRSLPAEESGLEKRQCSCKKVAGEWICSGRKCPRDLSHLMGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7M3</accession>
    <name>S0E7M3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mating type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431852.1">
        <property type="nucleotide sequence ID" value="XM_023578924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7M3"/>
    <dbReference type="STRING" id="1279085.S0E7M3"/>
    <dbReference type="GeneID" id="35399164"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05685"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="223" mass="25525" checksum="F47CDD9E9D22E62D" modified="2013-09-18" version="1">MANFVLMPPGASSPIVFTSKWTLEHIDRIYQCIHTDSKSSKLLKILPSLYNELDVGAKAGFANLYMVQLGMPVLYARDTQNNCYYLGAPCDFFAKGGMLVNIPGAPEVIFIHRPEKPAFPAKIPRPPNAYILYRKERHHSIKAQRPDITNNEISQVLGRLWNSETREVRALYKQMADQKKAEHRRQYPDYQYRPRRPSERRRRNNASSDSSTATTTVAQQITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7Q1</accession>
    <name>S0E7Q1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432975.1">
        <property type="nucleotide sequence ID" value="XM_023580148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7Q1"/>
    <dbReference type="STRING" id="1279085.S0E7Q1"/>
    <dbReference type="GeneID" id="35402554"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09080"/>
    <dbReference type="HOGENOM" id="CLU_036096_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="467" mass="52695" checksum="B065C5CA4105830E" modified="2013-09-18" version="1">MSTSHPAVELMFVNIARPQDIKDRKTQRRINSHVMKPIGITRRRARPDDKTEVTLKSLKSLSQHPEVACKGSSVSSNTSSPGIRAPETSWAFRYRHSMNLAPSLCSYSMPRGYPISTRTSTVDQEAPVCKLMRELCFALALADDSAMHLALARLEIDPERTEGWASEETASSLTHYNASIEILRNQLGGAQLMAHEAIIGVVLFTNNLARWKTHMSGLQKMIEYRGGIETLSSPYLQVTTIWMDLTGSMILDQIPHFKACQADPSTADYIQPNFNEAMDPAQRSHRDTETLLELLLKLSNLAAGKSERELSEDSVLLEELQASVYTTLTLPRYSPDMHQHLLASCVMTYEMFRLAVLLYLSGPVTFLAGNRTFNVVTPHLRGRLLRMYREHRLGWMGLEHVELFILVVGTLTEVGQDRQTLLVELQRIIRVQGLRWNGLVDKLRSMAWVDVVWSASLDKLHKDLAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8I2</accession>
    <name>S0E8I2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to mRNA splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430863.1">
        <property type="nucleotide sequence ID" value="XM_023577868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8I2"/>
    <dbReference type="STRING" id="1279085.S0E8I2"/>
    <dbReference type="GeneID" id="35401075"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07598"/>
    <dbReference type="HOGENOM" id="CLU_078549_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12467">
        <property type="entry name" value="RRM_Srp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034403">
        <property type="entry name" value="Srp1p_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT68783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="217" mass="25574" checksum="E0A925EE7BF821A7" modified="2013-09-18" version="1">MSRGGTTLYVTGFSHGTRARDLAYEFERYVNLVHAHAHALAHYTDLESDSYGRLVRCDIPAPRSTSSRLFAFVEYEDRRDADDAYHEMHNKRIGRDDILKIEWARTPPSASWRFESGRDRDRRGGARSPRRGRSPSPRRSTRDYSPRKDDRRDRDRDYDRESRRDRDRSRSPDHRDRERDSKDDRDDRDRRENGTNGDERKALDSPPPAHDDLDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E929</accession>
    <name>S0E929_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to phosphatidylinositol phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432366.1">
        <property type="nucleotide sequence ID" value="XM_023579548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E929"/>
    <dbReference type="STRING" id="1279085.S0E929"/>
    <dbReference type="GeneID" id="35399722"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06245"/>
    <dbReference type="HOGENOM" id="CLU_025224_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="480" mass="53976" checksum="6F1368F25D35A79E" modified="2013-09-18" version="1">MTPPSIDLLYLTFNCAKNLLDIPVFGSHLQTALRQNATGLPEVVVLSLQEVAPLAYSFIGGYFLNPYLSRYEQAINIAAQHIIDDLSSRNSETANTTPTALPSKPYTLVRGKNVGYTAILLFAREPSRLKNIQEAEVGFGAAEIGNKGAVGLRMLYEADGGSSELTFVATHLAAMEWNLPRRNANWAAIMRGMAFENPEVVVNSYKTSVTPSPASTPPAEDEPERARLLDNEHNEQHSQLQQQLHNISVFRPSSFLFVAGDLNYRISTTSPPPSATFPSLDPESENYYPDFFRLDQLTRERNAGRTLHGLSEHEVRFPPTYKYDVLPPRPGTREPEVDVPWKFAVHRYPSWTDRILFLDVPSWLKKGNSQDPKFNVRAYDCLPVLRMSDHRPVFLRMDVPLISPSDMAPPSDLDCGVSKDPRARLPMEIDPEAWERRAAARRKEVMAGWSMYLWSTKQGACILATVLAFGAGVYWLYQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E972</accession>
    <name>S0E972_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable tRNA splicing endonuclease delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433503.1">
        <property type="nucleotide sequence ID" value="XM_023580787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E972"/>
    <dbReference type="STRING" id="1279085.S0E972"/>
    <dbReference type="GeneID" id="35401981"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08505"/>
    <dbReference type="HOGENOM" id="CLU_083361_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="15"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="135" mass="15660" checksum="FD3BDBD8A7DEBD49" modified="2013-09-18" version="1">MDPSSDPVSNVTSTVVYNLQYQHDWVSLKVHETTVQRPLIRGLPPKRLYTHPDDQIAALEREGTTGEPLDQTPELEWVLAVHPEEKWCIKRFSEIFDSIERNGPREKRLVLAIVHNDSTVVYYLMHEGMVKPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA33</accession>
    <name>S0EA33_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_08424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433574.1">
        <property type="nucleotide sequence ID" value="XM_023580877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA33"/>
    <dbReference type="STRING" id="1279085.S0EA33"/>
    <dbReference type="GeneID" id="35401900"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08424"/>
    <dbReference type="HOGENOM" id="CLU_011409_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT71495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="554" mass="63010" checksum="92484562967E956C" modified="2013-09-18" version="1">MARKGKSKVKSGCKTCKLRKVKCDEGRPACQRCLSTGRACDGYGIWGGGSHALTQYSQSQSRPKFTLGPPLETTLVFSLNANEKLYFDWFKCRTSTKISATFSSGFWNTLVFQAGSREPAVLHALLALSSAHKKGVVTLDIHRNSPTSQMSQQEQFTLQQYVKAIAHLQPHFNAKDKESCRVALITCVVFVCLEFFRGHFATAQLHLKNGLDILWQMQGLPEANSGILALKPCHESTDAWIVEALSRLHMQVELFRLLYHHSCVILQPAHSPEKSFLESFANLNDAWKGLELVYNQIFHLTHRARQQTIAATEHIAQQLVKTRLAQWHGMFQDFMKALPGGSNISLQKAYQILRIHYAMTNVMSETCICNNETIYDTCTDKFILLIKELTKLWELSLHYELEDEMPLYIMTTCMPRSIIDMGWIPPLYFTAVKCRVHRIRAEAIKLLRTSPHREGIWDAHIAACVAKKVVELEEGDFYGGVDLGDDFQLNTPMRDLDYQVPLLPESRRMSEVEAKLSGAPMDKILLYCKREQEGVNRRTLISEYNVSEQAWSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA40</accession>
    <name>S0EA40_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to monophenol monooxygenase (Tyrosinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433833.1">
        <property type="nucleotide sequence ID" value="XM_023581191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA40"/>
    <dbReference type="STRING" id="1279085.S0EA40"/>
    <dbReference type="GeneID" id="35401618"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08142"/>
    <dbReference type="HOGENOM" id="CLU_035914_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495752" evidence="3">
        <location>
            <begin position="21"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="316" mass="35397" checksum="77D658EAC2034F51" modified="2013-09-18" version="1">MRFLSLTFPALCAAAAVSKCENPIKRVEWRELDDAARQQYTDAVLCLSTKPSRLGLNTTLYDDFPYVHAHLDKQIHAVASFLPWHRYFVHVYEGALKECGYEGVMPYWDWSLDADDTPKSTIWDPKTGFGGNGSLNKTESIYDGRAVRKCLDDGPFKDLLPAYLTTNYDPHCLARGWNDGSENVGKMLSENYNKEAVAKVQEVKDYDHYRQKLEAGPHGAIHSAIGGDMIPNTSPNGKSCILVPSFSKIIANSLWQQEDPKTRAMEFAGYKTQDQFDGTKPPPASLDDMLLMNGLADDLKVKDLMSTQSSLLCYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAA9</accession>
    <name>S0EAA9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable xylan 1,4-beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_06683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432771.1">
        <property type="nucleotide sequence ID" value="XM_023580036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAA9"/>
    <dbReference type="STRING" id="1279085.S0EAA9"/>
    <dbReference type="GeneID" id="35400160"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06683"/>
    <dbReference type="HOGENOM" id="CLU_016508_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF16">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495769" evidence="7">
        <location>
            <begin position="22"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="344"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT70692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="559" mass="63437" checksum="0A587A895DA771EF" modified="2013-09-18" version="1">MYPLTRFLCGWVVLFQPVAQAIWNPIISGWNPDPAILTVGDDYYIATSSFEYWPGIPIYHSKDLSNWTIKSHALTRPEQLQLYGTPTGAGAWAPSLSFIDGKFWLSAMTRWTYDPVARVWPRVWFISSEDLVNWSDPVWAEPWGIDPELFQDPVTKKTYLNLMAPNNNKDRLWGISQCEVSLASGNCVGPYVSLWNGTLPHNSTARPEGPKMYYKDEWYYLLIAEGGTDQLHRSTIARSKTPSGPFVAGPHNPLLYNGQWGFDNLTVQSTGHATLTKTNDGLWYATFLARRNINGSSPLGRETFMVNIDWKDEWPVFNQGDPVLLSKQIKPEVGPRQVPRQWVDDFSRTNLDPSWYQFRVPYTKNYKLEKGKLVLKPNVFGLSDRDTPAALLRKQKSLNMTFSAELSSFKGDLGPRNRIGISSYLSEFQHQDIGVRGCVNATGICIYTELNKNGTQEYWQTPLNQTSGLAGGFRLHIKAEPLKYRLGYSFGKEAPVYVTSIASSWQAFAPPNWFVFSGASWAIFATGDGEPWPHNGPQVGFNEVRETFHKENIPNYDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAQ8</accession>
    <name>S0EAQ8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434074.1">
        <property type="nucleotide sequence ID" value="XM_023581366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAQ8"/>
    <dbReference type="STRING" id="1279085.S0EAQ8"/>
    <dbReference type="GeneID" id="35407463"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14009"/>
    <dbReference type="HOGENOM" id="CLU_025283_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495726" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="68276" checksum="94ED5C46C4516CAE" modified="2013-09-18" version="1">MLFNAFLLGLFLATRPFLVFGGTSVIHAGNTPDDFVYNTLSLAPRNPTRPGRQPKDSKQKNSTSLDTSWVNAVLFAYTGCVYPYQPIEPLASSPDYVDMCSEQELGSKQGNTSVSASIEITCATCYIKGTATTEFIYDREFNISRAFSNFTNQVRREIDSLADQTADYIENYIDTVADNLDDGFDLDDFDLPPLDYNLNVDIPEIPEFRLQFQFDGVEVYMLIDTVLSAGATYTLNLYTSTTPAGFAVRDNLEVGVIFAIDLILSVEGEINISSGFHLRLDDGVLFDIAIFSKEISSLTMQKVNRNGGDFEFLPVTLESAGVVFKAVLRVGVKAGFEIASPEVSIAGKTIFNVGGGVEVGVFANIAELITNVTLSTDEDDDCSLRVEEVYQIAVGAAAGASVAIDDMTWGPVPETEIPVFYTTLGHACASQRSSDASLSVTTSPALQVREKNDDEVEMETTTISTKATFVVVACQSEGLVNCPMSLQTTSKYTTTRTHVTVVPTDSDADFPESVSHTVTSLIPFGNGAKKLVTMSGVPSSYVPPTTTTSAKENGKNDDPNGTSNGKSGGVSKSVIIGVSVGLGVPFLLGVIAVIWFLRKKRLSAAGTSLAPVEIVESMLPSSKSHGILVHEQRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC60</accession>
    <name>S0EC60_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to small s protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434547.1">
        <property type="nucleotide sequence ID" value="XM_023581940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC60"/>
    <dbReference type="STRING" id="1279085.S0EC60"/>
    <dbReference type="GeneID" id="35405800"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12344"/>
    <dbReference type="HOGENOM" id="CLU_002341_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="214"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="510"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="921" mass="106533" checksum="B5BBAF68D71CED04" modified="2013-09-18" version="1">MAARANVHTVSEFLARAVDVCHAVRGIHSLGYTDRCDTDFARLLEGLTHSVKRVEGEEGEYEKTLIRFACVQIGNDLVVHVNRVLNAFSDSIDVAGFCKLWPLDDVTALNARLRQVLHQCQDTFPSSHSQAVTLILKRLRRRDDAGKSPGQIPVIPRPPRLAPVGLINDFILESLSYKSMHDRESQVTEAHAKTLDWIFDNSPINQSLRQSFRDSFVSWLSTTELGPIYWITGKPGSGKSTLVRYLSQHPVALYHLRRWGVKKKVNTAGFFFWTSGSQQQRSQTGLLRYLLHQLLSSDPELIEKAFPDLWSRLRQMTTKERVNFALEWTVQDLQAAFHSLLDAALPSVNVCLFIDGLDEFDGDHVQIINFFRKLTSSYDGKSLKLCLSSRPWDVFEKAFETSVPNTKLQDLSYDDMYRYAADTLKTNDHIRRLMKQNPDSTHLLITTVVEQANGVFLWVRLAVERMLVTFQKNCEFEVLETTLKELPTELDDLFEKLLFKDQTSLEIMQTATLFQLMRAREIVAGFIKDESSNSLTVWELAFALFKEDDVVALDREVVEATDKEIQRRCGTAVQYIQARFARLLNVHVAKPMGNMRVPKFQDKNANIASLIMTSKVIYIHRTVRDWLMDGGAGKRLETLQSTDFDPHIRHLRSYVLRLKHPLEEIEHHRRLDEWYPDIALAMTHARYIIRDPQGLQRKFLDEMDKTLSWLWLKKPSDPYDHWAKSTFGAYEIRMKAPPIHRPFLCLATKFSLTDYVCQEVEDLSREEPAVEEEEEDGLTPLLSYATEFLCSRNKTIFPMSSPQLVRWLLNNPSRINRGPNHEYKHFITHQSITPWLSVLRHLRDAKRRGWIEYYDINPEGTARWAEIVREFVQFSDVRAVVLKDMWDPEITALGVIEMLEETYGSAEVQRIRVLMERNMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECA4</accession>
    <name>S0ECA4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hypersensitive response-inducing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434644.1">
        <property type="nucleotide sequence ID" value="XM_023582051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECA4"/>
    <dbReference type="GeneID" id="35405900"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12444"/>
    <dbReference type="HOGENOM" id="CLU_150781_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485091" description="Hypersensitive response-inducing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16089" checksum="71E1AD9DECEB9141" modified="2013-09-18" version="1">MKFFTTALLSAAAVSGYAVYEVRDFTASCIPHSTFCDYEFKVIQPGTMETWKNPVHCSAHVQSANYLLPDVKNAKCGDDSSRTFSVKRSKKGLTFTISQPVSPISDTVGKHFIPNKQLWQSKEPNAEIQRYKGPKDFKLNYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECX7</accession>
    <name>S0ECX7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable mfs-multidrug-resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_08228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433756.1">
        <property type="nucleotide sequence ID" value="XM_023581095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECX7"/>
    <dbReference type="STRING" id="1279085.S0ECX7"/>
    <dbReference type="GeneID" id="35401704"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08228"/>
    <dbReference type="HOGENOM" id="CLU_008455_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT71677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="474" mass="51659" checksum="9AE38752A0325638" modified="2013-09-18" version="1">MHNLIANDVENSISLDDSQSPPSIPDALKEEDRPVNWSSSKKWSIVVSTSLATFVVSFGSSVYSAAIPHIQTRFNVTPDTALLGITLYVVGFALGPMAWGPASELYGKRRPLFLGYAVFCICQLPCALAQSMPLLLAFRFFSGLAGSSSLAILGGMYVDFLSRPAERGISTAIFSVATFCGPTVGPIVGNLATLKLGWRWTAWLTLIGGVIFGSVAFLLTPETSEVVILRQRSKGNTSATPSRIYRPERGISIFVQSYLTKPVRMFVREPILIFFTIYMSLAYGIIYLTFTMYPLAFVTVRGWSRMDGSLPFIGMTIGVVLACIGIALHSIYYIQQSRVHVPERRLPPMIAGSILLSAGIFWFGWTSSRSVHWLAQASAGVFLGSGSILVLMSGVVYLIEVYLVHANSALAINNFLRCVIAATFPLYATDLLVDAGLGIGGTVIGSICLALSPVSFLFWRYGLTIRQWSKFAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED02</accession>
    <name>S0ED02_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_12651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434837.1">
        <property type="nucleotide sequence ID" value="XM_023582282.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0ED02"/>
    <dbReference type="GeneID" id="35406107"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12651"/>
    <dbReference type="HOGENOM" id="CLU_001550_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="203"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1447"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1702"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1945"/>
            <end position="1974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT72759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2066" mass="230526" checksum="EBCE8FC07C0E1745" modified="2013-09-18" version="1">MAEAIGLAASIAGLVQLTGSVFKQLIRFCKEAKDAPSKAQDLATQTRDLAGIFENLRLLASALEERDSGPALKPQHLESCQNTLNQIDSKLDKALSDFEGGKSARRFVRRLKWPFSLQETKDFVAELANHRANLHLALSADSMDALIKSLAKQDEIHSMIERRISFETRVELNKRRKEVMNFFLRVQPQDYLDVSRELRHEATGSWLTSDNSTFERWKNGSNSKLWLSGIPGSGKTVLCGLVIETILEQSDDLTAVCFAFCDYKNPDSCLPENILAALVVQLGLQGEEAFDLLEEYFDMLHPDDKLPTKPRLDDLVELVGCMSEVYEKVFVIVDGLDECGDQVTHMTRSLKAIVDGSEIVSSAFFSRKEEEIREQLAEGFEHIEVSAHVKDLEDYTLAEVSKRKVLKSIERTNPDLYKDILHALVHRAQGMFRWVACQIDHICNLPNNKARKRALSELPPTLNETYDRVLKRVMQCPPETQTCIRRALQWTALGSPKMNIASLCEAISFQPDMNVFEADDVIEPEVLSRNCGCLLRKSLDGNYFEFAHFTVLEYLEQTEVGDFRYSEEDAYRSFAQRSLGYLLLPQFDRVPTIIDTVEEAYAKERNQKHPFYKVAAYTPLGIHRSTNSYPMHLKVMEEETVLELLKRLFDIHKGGNFRAWVHALLSGGQNELSTMHQLSNGPLQFAVFLLSPKLCQFLIECGVDVNVVRDSFTPLATTIAMEEEGFLGEKMKDPRLIEQMIFIINVLLDNGADTAFVMEGQSCMAHAIGSLPGHYLLPFIRPSSAVPDDAVKAFSNFECKEKSDDLVLEAILRLAVGEEACPQWKPLAATALSFSRGRGLNLPHMALNPTAYSYSDLEYRQALEIAAKFGLVEELSTLILDPRYSDSIAEPSDFELLSATARSTSANSGKIIELLLESGIDPHVCGTSGQHCLHISCESSNVDTSWHAACYNGQENVISLLQRDDENALVNLATIDKDGRTPFSAALHSSHIKLALVLLDILPCEANYFVSKDSIMHVVAALGSLELLTALRDKGVTDTDVSNAETTPMHHLSATCTPEFARSLAELYDPFCADNSGTFPFQMFFERWLRHNIPVKFDETIPLNPEMLKVLIPKDNDFSHDGKVTHTWQLICAGLAKEEICCEVDTFVPIECYYYFSRDLTTLVKHGFLSSYESTRNTSGLVPLMGSLKDWTRDHFCSTSFVTLLSQVVESSKISISLQAIDDSYHFFRLAMLRASPEVIVKLIHLGVDVHRRVPEDISSSPMSLFEIACKEAGLEAFKAILETVTSQNVNAFRPTGQSPLELVVKGSSPDKTSLIKALDDKGLVQSPTDLATPVIIEAAKQNDLSLVKCLSEIGHDLFAVDVHGWGIPQWAATNRQLDILKWIVEKSSSPSQWQLAPASTWTSTNQAKTQIVDHQVSLLHFVADLPDFLSYFFENQFFDINISTLHGRTVLHYAAMRASMACCSMLLDQGINISAQDKDGKLAVDYALETGFNEVASFLLASGSPLPRGQVAVTGEMIKDLTSIEGLQLARRREFEAAIMNGNLAQCKVAINQGCFINQPLPSCHSCTPIFTAIRAQKPVIVNWLLDEGSSTYSFFCNRHPTQNLFTHAVTAMEPSAYIEKLLTTALKSRSITRAHLVDAICQNIGKRNLHVLKLILNHLKQNVDEYYNAWKGVLDSALGGDSAEQLKSALINYHNPVVFPHRTPLQVAAATGNVEMVKFLIQQGAHINVFDKHHETPLIIAASHNHVLVVTELLRHNAIVETSNMFGNTAMSLAVLMGHLDIVKLLAEERPSSLQYRNIDGSNLLLRASEESSSLATFKYLLSKGLDTHQKSEDGIPMLAFPLLQGRYIDYLSQSRWLDGALASPAPKPDNILNNAIVFCTTSQIKRLHKSLPPRDANILLNMESRSYGTPLCLAVFRCNVATTSLLLDLGADVNKVGSWFGTPLMCAITFGNLELVKLLIRRGAGLEYADENGDMVSGLEKGLPYPNITQWLLVGRFQDQKKLEDKAFYGECAIRPWSGRTEYTTLLKGSHRRRWEESTLDYCKRLAGLKRILRGSRAFVEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED08</accession>
    <name>S0ED08_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432367.1">
        <property type="nucleotide sequence ID" value="XM_023579551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED08"/>
    <dbReference type="STRING" id="1279085.S0ED08"/>
    <dbReference type="GeneID" id="35399724"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06247"/>
    <dbReference type="HOGENOM" id="CLU_028689_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="748" mass="78119" checksum="0C1DDD35A6381007" modified="2013-09-18" version="1">MAQTPYYGGNHPPPLFVAELDSEPGRPGDAPSHHRPDGTPVFEMSGEPVLPQHGQDGNQSSTSHNGPSSLQALGASKPALQGQEDQNKPSKDTPTAPQSVMANPWAYFGPESSDDKPKETQRPQTDTRRPSEPVYRPYPGDSDDSPPEVPHGTRPSTNPSSPDLKNEDYAFYPAPLKLAHRPANATSPPAFKAYVPPVTQDSSDLEPKPVGRPDRTDSQSPTDLNAYRPYRPHSTQPPASPVPTPSTHPATLSPNQNVPPVSPPRPPEQQPPGTVSHQITSTTPPSHNPNPPASGATLPKPAASLPASPKLQTQQSEPQPQIQYGIPNAAPAQPMPPSTSTYLPSPVTPSVQLSSVISSPATPATNAGVPFTQPQYAAHVAAQTYAQTPASAASTGPSHQTGVPFAQPQYATPVQAHNFGSNQSNITVTQAPASVMPTSASNSSQSTPVQFNYGVQQPTYSTPVEPAQSTLSQASAHPPAPYQQSITPGSKVQQTHAQQPNTRPYGIPVPTMISHSPPPPYAAQEPTTPMTGPPVNSGMPLSFGAGAQQSGSGNPTMYQPSPTGPYTSQPQYPTQPTYAPATSPPLPNHSGNSLQPPALPPRPSSSQGFAPTSGFGAGPAGYNPASYPRPPQTYFAPPPALPPRPGLGKLAGGGGKLFGSSSADKWLKKTGQVLESTLAPYLQGQSGQSASYRPGSNGLQGQQGQPMQQAPGQYPPQGHHFHVPHLAPQYRGASESGHPPQGPSAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EER5</accession>
    <name>S0EER5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to quinate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_10161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435243.1">
        <property type="nucleotide sequence ID" value="XM_023567857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EER5"/>
    <dbReference type="GeneID" id="35403627"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10161"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000388">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000451">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF48">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G06730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="565" mass="61271" checksum="24A5F86A43239D20" modified="2013-09-18" version="1">MAGDQISGEEQLAAVPKKGVWRQLRENPYIFGLSMFSSLGGFLFGYDQGVVSGVLTMESFAADFPRIYLDSGFKGWFVSTLLLCAWFGSLINGPIADYIGRKGSILLAVVVFTIGSAFQAGRAVAGLAVGMLTMIVPMYMSEVSSPGIRGTLVVLQQLSITLGILVSYWLEYGTQYIGGHRCAPDIPYSGGTSDKRTFDPRYDVGPNGCTGQSEAAWRVPFALQIFPALVLGIGMIFFPESPRFYLMRHKEDEALAALAQLRQVHVDSEYITAEYLAIKTEVMFDESVSAEKFPGKKGLSLFAAQHVALVSTWPAFKRLAIGCCIMFFQQFMGCNAIIYYAPTMFAQLGLSGNTSGLLATGVYGIVNTLSTLPALFLIDKLGRRPLLMCGAAGTFISLVIVGGIIGGFGSGLADNKAAGWVGIVFIYIYDVNFSFSFAPIGWVLPSEIFNLGNRSKAMAITTSATWMCNFIIGLVTPDMLANLGWGTYIFFAAFCLLAFLFTYFFVPETRGKSLEDMDLVFGDTASHEEKARLMEIASSMGLTEAVPGHKIGLAKEDDTTAEHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEV2</accession>
    <name>S0EEV2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to nitrogen metabolic regulation protein nmr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435288.1">
        <property type="nucleotide sequence ID" value="XM_023567915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEV2"/>
    <dbReference type="STRING" id="1279085.S0EEV2"/>
    <dbReference type="GeneID" id="35403575"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10108"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="305" mass="33358" checksum="489F180FAE61916A" modified="2013-09-18" version="1">MSKILTVFGATGNQGGSVVRAILNDPALSKEFKIRGITRDVSKPAAQALASKGVEVVAADMNTAEQVAPAVKDAHTVFLVTNYWETNSGNGEIAQGKAVADACKTAGVKQLIFSSLLDTKKISNGRLTHIKHFEGKAEIEEYIRQINVPATFVLPGFFASNLFTSIRKNEDGSYGWALPADGDKAKVPLFDVNADMGKFVKAAIKNFPGTINKRIFAATDYYSPNRIISEFSQVIGKPATFNQVPADVFESFLPAPIAKELTENMMLLEDPGYYGDADLKESLDLLDEKPVTWKEFVEQNRAKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF61</accession>
    <name>S0EF61_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435418.1">
        <property type="nucleotide sequence ID" value="XM_023568064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF61"/>
    <dbReference type="STRING" id="1279085.S0EF61"/>
    <dbReference type="GeneID" id="35403441"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09974"/>
    <dbReference type="HOGENOM" id="CLU_057358_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="277" mass="30643" checksum="4F4AFC3486DF7012" modified="2013-09-18" version="1">MSEVPIDDGKLLYFEERNQDQKESIVFLHGGGGSHIEWKLVAPQQSLSSYHLILVDLPMHSGSWDIGRPLTLATAADEVCKVIRKHAHGGKAHVVGLSLGGFIALVLTSRHPDVVLSTFSTGAYPYRGLFKWFFEHPMAMSIVNCIQSIPGVLEASLRRQGIDYEEWVAEGKKNHSPERSKAMNKELSAFSMEDVKAVADSGVRTCVISGGKMDQIDPARDMGVILREGGEKTGVKNEAVVVRDAYHPWHLQLPELFASGIAAWVQEKELPKEFEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFA4</accession>
    <name>S0EFA4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_09522</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435744.1">
        <property type="nucleotide sequence ID" value="XM_023568566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFA4"/>
    <dbReference type="STRING" id="1279085.S0EFA4"/>
    <dbReference type="GeneID" id="35402990"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09522"/>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_1"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901705">
        <property type="term" value="P:L-isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="84"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="267"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="476"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT73666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="668" mass="72553" checksum="383B689A5E4D8698" modified="2013-09-18" version="1">MLRTRQAAKAIRAVANARSFTTTSAVASVQTSKKVASTRNQSTAAAPARDIPSPGFNVEKNQSNVQPLVNPRKNDMDESFIGKTGGEIFHEMMLRHGVKHIFGYPGGAILPVFDAIYNSKHFDFILPRHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVITPMQDALSDGTPMVVFTGQVVTTAIGSDAFQEADVVGISRACTKWNVMIATSGRPGPVLVDLPKDVTAGILRRAIPTETALPSLPSAASRAAMDVTKKQLEGALQRVGNLVNKAKKPIIYAGQGIILSEGGPEILKELADKSSIPVTTTLQGLGAYDELDEKSLHMLGMHGSAYANMAMQEADLIIALGARFDDRVTLSIAKFAPGAKAAAAEGRGGIVHFEIMPKNINKVVQATEAIEGDVATNLKELLPLIESKTMEDRKEWFNKINEWKKKWPLTDYERAERSGLIKPQTLIEELSNLVADRKDKTYIATGVGQHQMWTAQHFRWRHPRSMITSGGLGTMGYGLPAAIGAKVAQPDALVIDIDGDASFNMTLTELSTAAQFNIGVKVIVLNNEEQGMVTQWQNIFYEDRYAHTHQSNPDFIKLAEAMRVQNRRVSKPEDVVDALKWLINTDGPALLEVVTDKKVPVLPMVPVGSGLHEFLVFDGAKDKKRRELMRERTCGLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFE6</accession>
    <name>S0EFE6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable BRX1 Nucleolar protein involved in the assembly of the large ribosomal subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435498.1">
        <property type="nucleotide sequence ID" value="XM_023568270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFE6"/>
    <dbReference type="STRING" id="1279085.S0EFE6"/>
    <dbReference type="GeneID" id="35403256"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09789"/>
    <dbReference type="HOGENOM" id="CLU_048373_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000464">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000465">
        <property type="term" value="P:exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000003">
        <property type="entry name" value="Ribosome biogenesis protein BRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="7">
        <location>
            <begin position="28"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="307" mass="34854" checksum="D94F7E337F9D4DD9" modified="2013-09-18" version="1">MAAVYKSISKSSTTKIEASSNGVKKNKQRVLILSSRGVTYRHRHLLNDIAAMLPHSRKDAKFDSKTKLYELNELAELYNCNNVLFFEARKGKDLYVWLSKVPNGPTIKFHLQNLHTMEELHFTGNCLKGSRPVLSFDGAFDKQPHLRVIKELFLHTFGVPQGARKSKPFIDHVMGFSFVDGKIWVRNYQINEVEATAKEGEEEEETTKSRSGKPDTDINLVEIGPRFVLTPIVIQEGSFGGPIIYENKEFVSPNQVRADIRRTKASRHNARAEKEVERRVRKGDLGLRSVGGQRPAKDELDTKMLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFH8</accession>
    <name>S0EFH8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to a-agglutinin core protein AGA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435523.1">
        <property type="nucleotide sequence ID" value="XM_023568302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFH8"/>
    <dbReference type="GeneID" id="35403227"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09760"/>
    <dbReference type="HOGENOM" id="CLU_030370_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="35"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="489" mass="53789" checksum="E8C1A9A512D9FEDE" modified="2013-09-18" version="1">MSGTSTPNGTIGSRPPSLTEILLDVASPPWTLSAFMAYLSQNHCMESLEFTLDSQRYAAFYNEMITNNPNRAQETNDRVCILWEKLMQVYIIPCAPREVNLPARIRDQLLGLPCGPIPPHPAQLDEAGRILYELMNDSLLLPFLQSVAPMQLDGPVDEHGRGSRRSSNSNTRMGAPVRSMNSMHHTDPESLTDDSDCNSTPGMEPMTPPTTPPTSEWAFTTSPGGLQRAVAAHNKGWKKMGAKLGSQVVSLPESSDEAYWTREISQEALEAEGSYYDHPLHSNSNAADDGWYHNPDLQQYGGFGDGTAAKFDTAQSGAKASLVQRNIRMRRRQNKPPELITNTQSARNKYTGQCQQASATPSYRPDLPALLVSSNYAGNNSIDNASMPMTDVSNYLPTPTTSNEDMRCPLTSSETEAFRYASPIEDLYGWDAELERREASPSRDSISSTEGLDAFALSYRRANGSKHSLLQRVFRVGSSSSMGKMETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFM4</accession>
    <name>S0EFM4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 17">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_09714</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 17"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435563.1">
        <property type="nucleotide sequence ID" value="XM_023568353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFM4"/>
    <dbReference type="STRING" id="1279085.S0EFM4"/>
    <dbReference type="GeneID" id="35403182"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09714"/>
    <dbReference type="HOGENOM" id="CLU_028491_2_0_1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="20">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="343"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT73485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="436" mass="48698" checksum="E5776662C87B24F7" modified="2013-09-18" version="1">MANHDVPDSTDWLTTPLTALAVVESALRCQICKDFYRTPMITTCCHTFCSICIRRVLSNEGKCPLCRASEQELKLRSNWAVEEAVQAFINARPATLDLARNANTKKISSKRKAVQDHHESGDAPDGKRLRSSTRLRNTRSPPSYTVPTEEDETVEFLEGDEDFQPEPEDGLVACPVCESRMKEWQVFKHLETCTGPVQRPRGNPGSSSNTSFSQQRHQTKAPDRLPAINYSMFKDQALRKKMADLGISNQGPRILLERRHKEWMTIWNSNCDAARPRKRHELLHDLDVWERTQGGRAPTTGRSIQNAAIIKDKDFDGAAWAAKHDSSFKDLIANAKRTRLEAKKKAEEAANESKVDGNTTPQENSDRMQDHSADLRAVSIPSSFPSRPAEGIPGRPSHSDSPSPGPSRSQSKGHRGSNRDSSRHPSDTREDGLSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGH6</accession>
    <name>S0EGH6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to isoflavone reductase homolog P3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433567.1">
        <property type="nucleotide sequence ID" value="XM_023580869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGH6"/>
    <dbReference type="STRING" id="1279085.S0EGH6"/>
    <dbReference type="GeneID" id="35401907"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08431"/>
    <dbReference type="HOGENOM" id="CLU_044876_6_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="320" mass="35351" checksum="EB207EFB1AB78FE3" modified="2013-09-18" version="1">MNVTIVGANGEAGLSIIDALSPSPNEFKLTAIVRPASINKPEIQQIKNKGVSVVPINLENNHDELVKALAGQDVVISCLVPFTTGPEIALADASKEAGVKRFIPSAFGPPCPPEGVMLLRELKETIINHVKKIYLPYTVVDVGMWYQVSLPSLPSGKIDYALKFPAAVVAEDGSHATSLTDLRDIGKYVAKIITDERTLNKYVFAYNEVWTQEGIHTHLENVSGEKIPRNSMPTKDIEATIADAQVKYDASDKSLPFIFGLAAPQYLYCEWFRQDNLPEPAKYLGYLSTKDLYPDFEPIQYVDYVDEVMQGKGKSIYANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH88</accession>
    <name>S0EH88_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to KP4 killer toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433817.1">
        <property type="nucleotide sequence ID" value="XM_023581174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH88"/>
    <dbReference type="GeneID" id="35401634"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08158"/>
    <dbReference type="HOGENOM" id="CLU_123452_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.10">
        <property type="entry name" value="Killer Toxin P4, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015131">
        <property type="entry name" value="Killer_tox_Kp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011329">
        <property type="entry name" value="Killer_tox_Kp4/SMK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09044">
        <property type="entry name" value="Kp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55221">
        <property type="entry name" value="Yeast killer toxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485933" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Killer toxin Kp4" evidence="2">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="130" mass="13813" checksum="ABBD96FEA8869E29" modified="2013-09-18" version="1">MQLTALLATALLAAGQAAAGINCKGSSQCAGGTQGEYTSSFVNLARGLDPNRWYYNGQHIMCTQHLCAFLQNTGGMPGSSIKTLISDLDAHGCNKCGSIPVFWPQDNDEKSHGILTINYVSSPKCNWAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHL7</accession>
    <name>S0EHL7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deacetylase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436203.1">
        <property type="nucleotide sequence ID" value="XM_023568546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHL7"/>
    <dbReference type="STRING" id="1279085.S0EHL7"/>
    <dbReference type="GeneID" id="35403008"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09540"/>
    <dbReference type="HOGENOM" id="CLU_074873_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="17261" checksum="182A81E4FBDCADE3" modified="2013-09-18" version="1">MARQRKEKSVKDIKLQQPDRSGPTKETLVDFAKGRDLFAEADRRQRELNGEGPLLSPRTERIFETILWTGVIATVHFTFDVLVQRQYAMEVDWFAIVQRTFTAWLLFIGLFYVLHPHYSHKSFFPLVPQHYQETVRQAIFFVASTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI13</accession>
    <name>S0EI13_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_10347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436378.1">
        <property type="nucleotide sequence ID" value="XM_023569120.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EI13"/>
    <dbReference type="GeneID" id="35403812"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10347"/>
    <dbReference type="HOGENOM" id="CLU_000022_31_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="46"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="931"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2398"/>
            <end position="2475"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="931"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="963"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT74300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2484" mass="273535" checksum="3EB30A3C561327EB" modified="2013-09-18" version="1">MDIPSWSVENANASIIDSVEAPHGDNSTNEQHLHNMENSVRDALEAPQIAICGIALRLPGGISNCEEYWDLLYHGLDARRPIPSSRFNIDGFNDSLGGKDSIKTKHGYFIEGDLSCLDTSFFSLTKNELERVDPQQRLLLEITHECLEDAGEINYRGKQVGCYIGTFGDDWLIMNIKEPLQGGLYATTGGADLMMANRISYEYDFQGPSMVIKTGCSSSAVALNEACRALQRRDASSAIVGGANMIMTPALTATMSSGEVLAPDASCKTFDAAADGYARAEAITAIYIKPLPDAIRDGNPIRAIVKGTAVNCDGKCVSLVTPNGAAHEALMRKAYCDIGLDPKDTACVECHGTGTPTGDPIEATAVGKVFGGEKQVLITSVKPNLGHSEGSAGLSSVIKCVLALEHQMIPPNIKLVNPNPNIPFSKYNLSVPLKPTPFPSNRLKRVSINSFGIGGSNAHVILESYTSEHDRRSTIVDQKGSQSPSLLLLSANTESSLQRQIRNYQEWTARNPNCISNLGFTLAAHRKHLPHRAFIVSQRERPSEVSSLSKIPSGSLSLVFVFSGQGAQWPHMTKELIESDTNFRSDLSAMNSVLQRLEFPPSWNLIDELLEPAENSRINRAELSQPLCTAIQLALVNKFSRLGLTPSAIVGHSSGEIAGAYAAGHISMEEAIVIAYYRGYVTTKQTLRGAMAAVGMGVQGISKYLTDGVVVACENSPESSTISGDADRVAQVVAAIKHADPDMFARLLKVDMAYHSQHMSPLSVKYQSFLESELSKHAVPNSSTKIDMFSTVTTELEDTCLRNPSYWTQNLTSPVKFSSAVSNLLATKQACLFLEIGPHSALAGPLRQICSSSSQPYHYVSSQSRDKDSSAVFLSALGKLYQHGIALNFESLFPNSKAISGLPTYPWDHSAAYWSESRISKAWRSREYPQHCLLGSRNFEGSDLEPQWRNILSLEDVPWLMDHKLKQDVVFPFAGYIAIAGEAIRQVTRSPLGAGYHLRHVISYRALLLSDSVEVSTSLRIHNLNDLDDSVWYNFAISSYDGSGWTKHCTGQVSILEKARTTNWVSEVLPRQVDCARIYRQLAQVGFIYGPEFRGLLDATVFPSRDLVHGRISNKTPQSHSPFTLHPATIDAGLQLLLVSQAMGLARNISELVVPTSIEEVEVSTGSDLMDAKAWRLHGTDLCVELDAGGKVALHASGVQLRALGEDTSFDALNIHATSRLNWLPHFNFVDASKLFVPPAINREECHLQEELTLLCIIETVEKIKSLEPCQPFFTKFRDWLKRQLDIAASGDYKLVSQSRQLLDIPHELRLSRIEDITRKLVGMPQKALTIGLRRLFDNMENLFTGKAVAIETLLKDNVLADLYNVMTFDYSRFLRILSHTRPTLKILEVGAGTGGTTETILRGLAQVRGLPAYAVYNFTDISAGFFPAAKDRFSGAPNMEFNVLDVSQNPLEQGFQAGTYDLIVAANVLHATPSLHETLRNIRQLLKSDGMLVMTEVCSLSRLTNYVFGNFSGWWLGDDDGRPDQPYVPVSRWDQELKKAGYSGVDVAVYDDEEPYRHCAVIVACKEPPVVSRPSYVTLLARHPYSYPATQVSSALETRGWNVTVQRIEDQVPQNQNIISCLDLETAFFEDISQEMFIKFQECAQSLGSSSVLWLMSPSQVGCSNPRSAQTLGVARTLRSELGLNFYTLEIGLNEGRFGILITSVFEKVIRERDSEALEPDKEYIVHDGTVCVGRYQPVYIAEEALDKVQSGEVMKTLRVDKPGSLETMNWIASAIPTKITEDEIEIKVHSAGVNFHDVVSAMGLIPSENPHVFPGIEVSGVVKRLGSTVTGFSIGDRVMSICYRGGFSTHFTAKHHYMHKIPDEMSFEEAASIQCCFSTVIYALLDVGKMRKGTSVLIHSACGGIGLAALQVVQMMEGEIYATVGNKEKREYLVKEYGIPRKHIFHSRDASFLEGVMQQTAGKGVDLVLNSLSGELLNTSWKCVAKSGTLLELGKRDLVSCGQLDMGGFLENRSYCGIDLHYLIGEQPILVKDVMDRTLEFFRQGKLRPLRPITPFPASDAKKAFRYLQDGQHIGKVVLEMPIDASDPEAKVATQTIQFDPLASYFLVGGLGGLGRALAVWSGMTDDDGKFFVELEALGCNAIVVKGSVNNLKDVEEAISKAPYPVKGVFHLAMIQMDCPLLHMKWEDWKEAIEPKVNGTWNLHRALHGQPLDYFWLASSAVTFADQPGQGNYKSGCIFTESFCQYRHSLGLPASVLSICGIEDVGYLAENPSALRSIKLQGLHTVREKEFLECLEASLSNSAPSSHSSAGGSFENLASSEWSPWKNNGHILMGMRSHLHLDDPKNPTNWRRDRRMGAYHNFSTGDQSDTRGERSQLKTFLQSISEGDIGILAKKESIDFLSIEIGAKANDFLLRPDVPIDPNLNLSEIGLDSLTAIELRRWFSQVFGLQVSVLEMLGAPSLREVGKIVATRLGEKLKRRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI30</accession>
    <name>S0EI30_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436527.1">
        <property type="nucleotide sequence ID" value="XM_023569292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI30"/>
    <dbReference type="STRING" id="1279085.S0EI30"/>
    <dbReference type="GeneID" id="35403966"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10502"/>
    <dbReference type="HOGENOM" id="CLU_030805_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA C-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="182" mass="19181" checksum="572A3769E1F5EE7D" modified="2013-09-18" version="1">MATFKHDKRSSETISDIAKDVIRLLKEEKETVGVAESLTGGSIMAALTAVEDASSVCRGGIVSYNTGIKVNILGVSQSIITKHGAVNGEVAEQMAAGARSITTLDTPTTWGLSTTGVAGPGTEEGKAPGTVVIGISRAGQDRAFGPFYFPGDRSAVRKATVVKALKQLRELLRDRDHLDERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIN4</accession>
    <name>S0EIN4_GIBF5</name>
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        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435800.1">
        <property type="nucleotide sequence ID" value="XM_023568635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIN4"/>
    <dbReference type="STRING" id="1279085.S0EIN4"/>
    <dbReference type="GeneID" id="35402928"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09460"/>
    <dbReference type="HOGENOM" id="CLU_909243_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="226"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="311" mass="34439" checksum="88A5ED2C0A2FBC86" modified="2013-09-18" version="1">MMMSSTFLESASDGDGAARFGRMPDDWMNGIDTTAMPFSSLDAPYEASTQQNPLQSPETPSLDNTVFPSPLTDLAYLDRSFGDFSPNGYAIHSTTPGQFPVHPPHRTSSAFSEGYDLSTGSPSLGAVWPAHVSPAATFLPTPPMADELSPAESEPEEDNQDDDEDYDDDSEPASKKRKRSTVTKTRAKGKEGPKRNPTQLRTASRAPKKRVVAQPRHPSETTEEVKARAAHNQVEQQYRKRLNTHFERLLAVLPAPGTEGGIANDRRVSKAEVLDLARERIRALEKQTARLERERRELRGRIAPDTRRCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJC5</accession>
    <name>S0EJC5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434556.1">
        <property type="nucleotide sequence ID" value="XM_023581949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJC5"/>
    <dbReference type="GeneID" id="35405809"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12353"/>
    <dbReference type="HOGENOM" id="CLU_1825389_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="148" mass="16959" checksum="B943C99B1E433E03" modified="2013-09-18" version="1">MPENNKSVSVQLWPWQKRALENGRTPLPESPGERPWLNLSQDAEISATPLSALTNASTPERRNYHLTVATPNQRWWTESEMRRLIQLRNNGETWATITAQFPGRTLQGVKQTYRKRRFATEKQMEKEALAAASANPSLIRDDAEKCNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJD1</accession>
    <name>S0EJD1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_09197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436045.1">
        <property type="nucleotide sequence ID" value="XM_023568928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJD1"/>
    <dbReference type="STRING" id="1279085.S0EJD1"/>
    <dbReference type="GeneID" id="35402666"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09197"/>
    <dbReference type="HOGENOM" id="CLU_028200_12_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF108">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="44"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT73967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="387" mass="43175" checksum="D6D36CFBC2393B20" modified="2013-09-18" version="1">MTKPAMEPPPGKESNFDNPDRELYYICIASNAIAMSVCSIFVFLRLWARYRLAMRLRLDDIACVIGYIGFMGYCTMCLLMLRYGGGLHQWDVPDHLITQYNQTVYATMVNYGPTVFAIKAAILLFLASIFAPYKTYVKWIYGFLGVMGVYYVAMFFLKMFICRPISMFWGATTDGECFNQRVLILVDNIISLLSDIVVLLLPCPLTKKLQVGLIAKLKIVAIFGVGGIACIFSLVRLVFIIHNGESPDQTYVFLQINLTGIAECGIGVVCACFPFMPMLWKSILHKDKPGYSSNYSRSQFEMMSSSKQRSRNTGHTPESVHYNEDMGSDENILIPNGKSYVTTNVRAGDITAEGNTGSIGDGNGGHGASLDDSHILRTVEVRQYEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJE8</accession>
    <name>S0EJE8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437199.1">
        <property type="nucleotide sequence ID" value="XM_023568984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJE8"/>
    <dbReference type="STRING" id="1279085.S0EJE8"/>
    <dbReference type="GeneID" id="35403691"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10226"/>
    <dbReference type="HOGENOM" id="CLU_966596_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="288" mass="25096" checksum="661DBF6568DCF281" modified="2013-09-18" version="1">MKYKVYVAALILTAMPRVSGHPILDHRSKQLDYTSNIEKSQQSSRPQGVSQLIPDKQTIRAVLNIPEIARLPRQVGGAGGSAGGGTGGGSAGGSGGGSAPGGSAGGGTGGGAVGGGGGGTGGSAGGGTGGGSAGGPGGGANSGGSAGGGTGGGAVGGSGGGGNFKRGFLILSRQESPGGAGGSAGGGTGGGSVGGTGGGGGGGSAGGGTGGGSGGGSAGGTGGGNGGGSAGGGSGGGSAGGSGGGEWGWASVGGGTGGGAAGGSGGGNGGGIGWRRDRRWWCWGLWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKI1</accession>
    <name>S0EKI1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to L-PSP endoribonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434986.1">
        <property type="nucleotide sequence ID" value="XM_023582455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKI1"/>
    <dbReference type="STRING" id="1279085.S0EKI1"/>
    <dbReference type="GeneID" id="35406261"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12805"/>
    <dbReference type="HOGENOM" id="CLU_100715_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06152">
        <property type="entry name" value="YjgF_YER057c_UK114_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="140" mass="16051" checksum="A692062F2F8B145E" modified="2013-09-18" version="1">MSHLTYTAYEGYGERAKKDLWYSQAVRVGDIIECSGQGGWDRETEKIDPNVVIQIEKAFDNVECALKAAGSRGWEDVFFLRSHHLPCNSEAIETMVRCLKKYCPNHQPTWTALGVPRLALDDMRVEIEVRAHVPKDREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKK1</accession>
    <name>S0EKK1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437198.1">
        <property type="nucleotide sequence ID" value="XM_023569980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKK1"/>
    <dbReference type="STRING" id="1279085.S0EKK1"/>
    <dbReference type="GeneID" id="35404581"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11117"/>
    <dbReference type="HOGENOM" id="CLU_009030_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="641" mass="72506" checksum="CEDFE7CF7691276E" modified="2013-09-18" version="1">MRKKSKTFTGCWTCRARRVKCDEVQPVCNRCTKARRICEGYGVRLTWTSDEKDTPFRVLIDLDTDAVEIPQEDLDDMIHKCGYTEASLETQTFGPFSVFCVGQGTDFEPSEPRHLDTKEGREEQQLQREAATENLYTPSSNDSLLGTCQPSFSESSNEAISDITIFDIFAHQATGSNQGYVDENDDLVLDELFSAERFFGPSSFELESQVSSWAELDVFPSDMENDSTSTVEMPLEGYSPSDHSQFNNIPFSFCHEVPPPQTSLTPISMSRQQTELIHHWLVHMCRNMVPIDTLDNPYRVTYLRLASEGVNGTSKSHIAVLHGVCAAAAHNLNTLRHDKMNTQSAWNAQVALQNLQESISQPKGMDDTSVLAAIVMCIMQDTMTGHPRGWRTHIQAALRIIVQGKLYQGLDPGSELHVVVLQCLCLVVLGDVDTHYDIADMVSQLPRTEDYVSKHHSVTKDLVGIISRINTFSKQNAARDLGLIDQLELQIYLQVGPTTPHNRFRSAKVNFINQHYASVWHYATIIHFQRRIRHKPAEQLRDIVSEALAHLEAAEDVATELDGCIVLWPCMVIATECDDEEHKMRALNWFKKKDRHAFANVSLASSICLEYWKWRDRNPSWALTTSWQDFVAGTKYDVVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKP0</accession>
    <name>S0EKP0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435041.1">
        <property type="nucleotide sequence ID" value="XM_023582517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKP0"/>
    <dbReference type="GeneID" id="35406317"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12861"/>
    <dbReference type="HOGENOM" id="CLU_1180274_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="263" mass="30032" checksum="357042D2F6972618" modified="2013-09-18" version="1">MSLKRRGSELDHEAKKMKPDDSHGHDEVSSSSLQATTPLPHQSVTDLANLPQTARTQFDYLLQALSDISPETLYEVNILDHINAINSDGDSPPEFTYEPPEIEIMVGHKHGTLFHCSCLKFNLLISLSGSDSTHGCEDPACDKYFAKAKAMPYADGSRYFTVEVVQLRHLKGGKYWLPCREWKYSRSTFEVKPWKEKYLRRIQTLVGKAVVSHNREVLAWWVRKITHAETPLEPFKGREEARGKFLSGLVVWTGPSRDAWYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELS4</accession>
    <name>S0ELS4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436930.1">
        <property type="nucleotide sequence ID" value="XM_023569764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELS4"/>
    <dbReference type="GeneID" id="35404388"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10924"/>
    <dbReference type="HOGENOM" id="CLU_038504_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="426" mass="50241" checksum="4523E21830A526BA" modified="2013-09-18" version="1">MFGRFQESKKQWRNCIVACFAIYALGFLFFYYSFPAFGDFHRPHHHHAVSVTKQSKHVKPDNITVSGLVFYGRQSRVEIMKCYIERNLVENGGWLDEVLWVVNTEQKGDLRYLEEILASNPQRYKKIYSDEIAGTYTYKNIWKKLDRGKYYVKIDDDVVWIDDNAIPSLVTRKVQNPKDFVVSGNIINNPPLGFFHMRMGAIHPYFPEAFEPFSVTNATDYWRPSRHPSWDGPKKYKWELKNEPPSWPNHRWLRVPDDAMLDQTPAAELKYDIWGDSYRNWAIASQMHMSLFENIEKNQLDLYKFEKTWTMYEDRIRINFMCIYSDDILDTDPENWPQGRGDEDMIVLDLPKKLRRPVVIQGDALAAHYQYMDQKKLESTDILRRYQSIAKDKYCLNLDAARDVAEADLKQRSIRGLFSTPSGYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM01</accession>
    <name>S0EM01_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437902.1">
        <property type="nucleotide sequence ID" value="XM_023570849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM01"/>
    <dbReference type="STRING" id="1279085.S0EM01"/>
    <dbReference type="GeneID" id="35405360"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11900"/>
    <dbReference type="HOGENOM" id="CLU_110344_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20018" checksum="76F9809FA8D0A928" modified="2013-09-18" version="1">MSQSLAAFRSGRSDELRKLAEEHFQHDLNENDRDILKTAGSKVSTHATVGSLLGLGFGVLCAFRLRKMRLAYFNAFRAVEKPVEVKFADGRTQPIPDLTAQLAPSKWGDAATYFFFSIGGLFLGGETGLLSGTASASRTITKNPEAKERIEKAWKNYRIDVMKQEIKQLEGKSKLEQLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMH0</accession>
    <name>S0EMH0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to regulatory protein for the arginine catabolic pathway</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435636.1">
        <property type="nucleotide sequence ID" value="XM_023568437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMH0"/>
    <dbReference type="STRING" id="1279085.S0EMH0"/>
    <dbReference type="GeneID" id="35403106"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09638"/>
    <dbReference type="HOGENOM" id="CLU_008719_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF40">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="784" mass="88242" checksum="6B8D19F3065045AA" modified="2013-09-18" version="1">MPFPAEWQGYSPGPYAIENNIDFEMFDFEVQHHSHMGATPISEPPNISQDPKGLSMENPREMTFQSPMPSSNPTPVKGKRVRTGCLTCRERHLKCDEAVPDCMNCRKRGRECKRGVRLNFLDVNLHRPPDIPSPGGWEVEFQDESRDIASEYQGGLGRYAPYASEIVEDSDGRHETVYPATATHIQGIDASADRLQPGAQHRFNYSQDNAAAGPSKNSRFKTDTGIKLELNENEHGTLSDASHIATPSSSTKAVVTPRAEVFPEQLMAMRNRPLARQTLSEEAENLIIPQLDTPPRIERPLVEQAFEDDHMQPKATQSNESVGRNILTSAEEIHYMQVFVEEVAVWMDSFNREKHFTRSIPYHALRSTMLLNALLACGVKHTSLAAPDNHEKALFYYNTATTQLLRSLQNPDRNTAECATTAIVLNVYEIMCEKPAQRMSHIAGSRALVRECGWDARSTGIGLACFWLNIGIEVLNCLATNWQTTWSPDEWGMSLGSRSNNQDDEDEDEQVWVHRALYIIAKVANFRATASRPDDISPHNEQTWVRNRLSQWYELRNLCEGWNIHCPRKMRPFGYVKAEKSTSKSLFPGIWMIQREATIGQLLSHTAHCILSQTHPLESPGSSERLRFLQLQHAYQVCGIVAHTTDKGVATVAIRCLAIAAAVLTNPDEQDEILEVLDRFNSTNGWRLGAVEMELKREWGWERMKMPTSSPKTENSQDSVISAVRRASMSLTPSRILTPPVMGPVGTKTPVNPLSFADFKLPNHPYQNWYEPPSRSSSFNPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENR8</accession>
    <name>S0ENR8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reticulon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437860.1">
        <property type="nucleotide sequence ID" value="XM_023570800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENR8"/>
    <dbReference type="STRING" id="1279085.S0ENR8"/>
    <dbReference type="GeneID" id="35405315"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11854"/>
    <dbReference type="HOGENOM" id="CLU_479824_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="64"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="595" mass="64380" checksum="45BBDD0B9D8EF625" modified="2013-09-18" version="1">MSGLRDNFQPVLAEDAPRSQNNVERRDSGPLKDIIGKRMPVIEQKSHVSDFRATAQQDSLYKYISWEDPARTIVSYFAALGFMLAVHNMHLTQLVLKTMAIGLGVMSMAEFAGRSFGPNNFVSRMRPRQYKTVPESTLNATLRDIHDFIQYAVVQAQKIMFAEDLEKTFGAFVATGSLYFLIQFMTPFGIAILGLTTIYIIPLVTSPRGRGIARDGMARAQEISNAAVDQASSIAQDPKGTVASISSMAQDTAGNLRQRAVNMVPGSKQTENRDDVTSTVPHSSSGPTQARDISSKFPQDDSKSSEQSKHLASMGSRGTSGSFDRSPIKTAHVDPNQSKDFSQSSFDSSSSQSKDNPSTFSHGTTDDFPSNTQPALGKSKDNTPSFSHGATGSLPSYGQATFSKPQDPTPSYMSSKAKEATSTYSSSRTDDKTSSFGSSMNKDMSSSFPHGTTDDFSPSSKISSNFPPSKDQGMPEYAQHRKSLNYSKFPHVSSDNSGTQSSSNKPSGSTTLFGNQAPAGKKPSIDETNYSLQNKRDMTSDYQHFVPREAPNRGMLSSQADTSMGKMPLGELVDEKEQAGDKAPPISGGGLNAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPF1</accession>
    <name>S0EPF1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to formate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437086.1">
        <property type="nucleotide sequence ID" value="XM_023569941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPF1"/>
    <dbReference type="STRING" id="1279085.S0EPF1"/>
    <dbReference type="GeneID" id="35404547"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11083"/>
    <dbReference type="HOGENOM" id="CLU_036896_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000011">
        <property type="entry name" value="Formate family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="343" mass="37494" checksum="96301A976F3C6C30" modified="2013-09-18" version="1">MSNPLVVSISNLAAYTPQETIELVSRSGVKRGNMRPDKVFLSAVSAGCLLGFGCGVSLCAMTAPWYTENAPGLVKLFGAGVFPLGLVLVVLTGADLFTATTMFTLTAVLQGRLPIRKMLLHWFLCFFGNLAGSLFVMSIIMGCKSRQPLNAKVAIDIFLDGGVFDASPYKEVVMSFASKKQISPQVHQIFLKAIGCNWLVCLAVFLGIQAKDLASKVIGMWWPIFAFVVLGLEHVVANMFYMSLAIWLKTPDLTVGLYIWKGMIPATIGNIIGGGMFVGVYYWYMYLFNEDPVKVDGVEYQGPHVDSHMHMHFLANRNKSTVTDEESRIESAPVSVPASVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHQ4</accession>
    <name>S0DHQ4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423855.1">
        <property type="nucleotide sequence ID" value="XM_023575373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHQ4"/>
    <dbReference type="GeneID" id="35395223"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01738"/>
    <dbReference type="HOGENOM" id="CLU_1421510_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="191" mass="20502" checksum="45FBAE48D8174571" modified="2013-09-18" version="1">MSDIPRVNSGYKRKKSEGHQVMQNLEASSLASFKTTEDSENISGAAKKGGNSSDNGSPPTKKKKRTHKPRKVIKGQPPTMASACYDCAHIRSSCKVPVGQAVELGQQLQNFALHIVDSQSADERATQVEWLQRAKAAKASLTADQEMPSVAPNQGSQSASEELDPASSSNMPPVGRMERFSTVPTHPIQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIL0</accession>
    <name>S0DIL0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_01444</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424126.1">
        <property type="nucleotide sequence ID" value="XM_023578639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIL0"/>
    <dbReference type="STRING" id="1279085.S0DIL0"/>
    <dbReference type="GeneID" id="35394929"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01444"/>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="87"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="346"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT62045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="753" mass="85290" checksum="1692DB98D52929BC" modified="2013-09-18" version="1">MSSDQADAAKAAEGASEKSLPSRPAKQPKEKQPKDKSAKGGKSAGLEVGVPFLAALPETPEFIQHRLDLFDKIKARQDAEIAAKPREEITISLPNGKEEKGTSWETTPGAIAKGISKSLFERTVISRVDGELWDLTRPLEKSCKLELLDFEHTEGKKVFWHSSAHILGEAAEKRFGCYLCNGPPTEDPPGFYYDMANMGEQVVTDEDKKALEQLSNNIVKQKQPFERLEMTKDELLEMFKYSKYKEYFIQQRVPDGTKSTVYRCGPLIDLCRGPHVPTTGNIKAFSVLRNSAAYWLGDSNNESVQRIAGISFPDKKALEEYKHFLAEAAKRNHRKIGTDQKLFFFDEASPGSAFFLPHGVRIYNALMELIKGEYQKREFDEVMSPNMYKADLWKTSGHWGHYEENMFTFEVEKEKFGLKPMNCPGHCKIFAHSDVTYKDLPWRMADFGVLHRNEFSGALSGLTRVRRFQQDDAHIFCTVDQIREEIESAFDFLSSVYGIFGFTFKLKLSTRPEKYVGDIATWDSAEKKLEEALNSFSEKTGAKWEFNPGDGAFYGPKIDIALFDALKREHQCGTMQLDFNLPRRFKLRYVANKGETGVSDGSNPEEDLPAGYARPVMIHRAVLGSFERMFGILTEHFGGKWPFWLSPRQVLVVPVMPAANDYAKEVQQIFRAKGLYSDVDLSSNTFQKKIRTGQLEQYNFIFVVGAEEASSRTLNIRNRDDQATQAKGELVPIDEALEKMVQLKSSRGLVNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJG8</accession>
    <name>S0DJG8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to F1F0-ATPase complex, subunit h</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424541.1">
        <property type="nucleotide sequence ID" value="XM_023568930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJG8"/>
    <dbReference type="SMR" id="S0DJG8"/>
    <dbReference type="STRING" id="1279085.S0DJG8"/>
    <dbReference type="GeneID" id="35394474"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00989"/>
    <dbReference type="HOGENOM" id="CLU_122989_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="128" mass="13997" checksum="42E0547F6360623B" modified="2013-09-18" version="1">MLIQLSRASRARSAVAAVSRVARPNAVQVRGFIAPTVSRKADFVQELYLKELKAYKIPAVKESDAEGNVQTFNVPKTPASPEETDLAGNLKEYESMAVEIEGQDSSAQSGTPEVADWLEAEEEDEPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJH6</accession>
    <name>S0DJH6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable calcium-binding protein cnx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_01010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424522.1">
        <property type="nucleotide sequence ID" value="XM_023568696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJH6"/>
    <dbReference type="STRING" id="1279085.S0DJH6"/>
    <dbReference type="GeneID" id="35394495"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01010"/>
    <dbReference type="HOGENOM" id="CLU_018224_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="523"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT62441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="561" mass="62551" checksum="3EBA4820CDF6FBB4" modified="2013-09-18" version="1">MKLNAVAAAMSAAMLTGNVHAEDIKEASPSVPDKLPTFTPTVVKADFLEQFTDDWDQRWKPSHAKKDTSGSEEEWAYVGEWAVEEPVQYKGIEGDKGLVVKNPAAHHAISAKFPKKIDNKDNTLVVQYEVKLQNGLECGGAYMKLLRDNKALHQEEFANTTPYVIMFGPDKCGHTNKVHFIFNHKNPKTGEYEEKHLDSPPTAKITKTTELYTLIVHPNNTYVIKQNNEEVKTGSLLEDFTPAVNPPAEIDDANDKKPEDWVDQARIPDPEAKKPEDWDEEAPYEIVDEEAEKPEDWLENEPATVPDPEAEKPDDWDDEEDGDWIAPTVPNPKCADASGCGPWTKPMKRNPDYKGKWTAPYIENPAYKGTWAPRKIKNPDYFEDKTPANFEPMGAIGFEIWTMQNDILFDNIYIGHSIEDANKLAEETFGVKHPIEKALFEADKPKQEDKPKSPSDLKFLDDPVHYITEKVELFKAIAAQDPIEAIKFVPEVAGAFVAIIITAAGLVAVLFNLGKSPAVQQTAEKASDKAKQVKDKAAEATATGAEQVKGAVNKRTTRSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJL1</accession>
    <name>S0DJL1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424596.1">
        <property type="nucleotide sequence ID" value="XM_023569585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJL1"/>
    <dbReference type="STRING" id="1279085.S0DJL1"/>
    <dbReference type="GeneID" id="35394415"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00930"/>
    <dbReference type="HOGENOM" id="CLU_606968_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd00385">
        <property type="entry name" value="Isoprenoid_Biosyn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="451" mass="50842" checksum="81511329EF5A9BD7" modified="2013-09-18" version="1">MDRSTPPTKFEKDYNTLLDGISKFPASPNHPSGSEAQDNHQSHTGPMQAGNTPEDWTVEDILKVQQENNAAILDSIRLISSNERSTLAQVVHSEFQNGMDRICNYVKNLVPQPAQASTASTITDLRAQLKKETNYTQKLSADYNNLLQHSHKQRQDLAKVNAKLDDALRERDQLRQLLGGGSLANSDKATDDSIRGKWKVLAYNIRCLARHLAHNPPQQQLDDLAKDRLRFVARDYCTLLEDKDYRELILMSYLWVTVQDDVFDAGHTVWGGPELKSFKAVRDHIISRFGDDVSIPNCDDPIAHAARWLAQGSVMMSNLWGRDDRAMRRLVLAEAKRLRSFHSTPQSTADRCDKKVTDQLRDILDSAIELDQMMMSSKATFVTHWRDRSQSPGTAEMWNEGVMNSEASTNTLSPKSRVLFFISPVLHKFGTADGQRYDSSMVLAKGLVVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJP6</accession>
    <name>S0DJP6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_00880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424641.1">
        <property type="nucleotide sequence ID" value="XM_023570141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJP6"/>
    <dbReference type="STRING" id="1279085.S0DJP6"/>
    <dbReference type="GeneID" id="35394365"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00880"/>
    <dbReference type="HOGENOM" id="CLU_034705_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061852">
        <property type="term" value="C:retrograde transporter complex, Golgi to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="141"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT62560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="439" mass="48511" checksum="213AD7C8510D4EF2" modified="2013-09-18" version="1">MPPKSRFTRLDAFTKTVDEARIRTTSGGIVTIVSLLVVLFLSWGEWAEYRRIEIHPELIVDKGRGERMEIHLNITFPKMPCELLTLDVMDVSGEQQHGVMHGVNKVRLQPANQGGAVIDIKSLALHDESADHLDPSYCGGCYGAQPPANARKAGCCQTCDEVREAYAQSSWAFGRGEGVEQCEREHYGEKLDAQREEGCRIEGGLRVNKVIGNFHFAPGRSFSSGNMHVHDLKNYWDVPKGKAHDFTHYIHSLRFGPQLPDNIAKKVGTKSSLWTNHHQNPLDNTRQEIHDPNFNFMYFVKIVPTSYLPLGWDSKGIKIAGLLQDDNAGLGAYGYSEDGSVETHQYSVTSHKRSLAGGNDAAEGHAERQHTSGGIPGVFFSYDISPMKVVNREEKAKTFSGFLAGLCAIVGGTLTVAAAVDRGLFEGAARIKKMRTKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL80</accession>
    <name>S0DL80_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425455.1">
        <property type="nucleotide sequence ID" value="XM_023572073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL80"/>
    <dbReference type="GeneID" id="35394191"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00706"/>
    <dbReference type="HOGENOM" id="CLU_1086043_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="256" mass="29724" checksum="B67F19E235A8A67D" modified="2013-09-18" version="1">MTSRRSQFAKEAPPGAYFQDPPYVYTVHQDPFRKVPARMAEDYSPMYPPSSAATNIFVPGCCRHRRRASRYSKTYESEGSTKSYASYEDVQPAQPVDRLPPRIALKQLSDFLHEAGIFYNTQLMDFAREHQRQGHDTSNEALRQWLWNDWTRSRDNPTRENFTSTKASITLLLRQVETAIATPWLENADRNVRFDFSYKVLKSSCDEVVRLSGKVMSDWQTCRFLAVELKNARVYADPEGPVLRHLFVGWEKGEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM01</accession>
    <name>S0DM01_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423629.1">
        <property type="nucleotide sequence ID" value="XM_023569751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM01"/>
    <dbReference type="STRING" id="1279085.S0DM01"/>
    <dbReference type="GeneID" id="35395455"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01972"/>
    <dbReference type="HOGENOM" id="CLU_006632_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="324"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="640" mass="71796" checksum="6864AC08B21F4813" modified="2013-09-18" version="1">MDHSHSQAEASDRERATSSSSTATPRKFSIRSNFAHRPTSGPGPESSRSHDALSPESASASVSASGTSAISPSAPSEATRHRSESAAVVHNGLVRHPVPVPGEASLDRSISLDPPRLEPNQEVAYALEDVPGRTAHAMALGSEQDPYFLDAFRSVLLSEREGIDANFVQVYHGGPDVDDYPMHFLLLLDEFPDHRNEAKQMASDAIGRIVWPHGPALVRLYFRHVHVGLPVIHKTRFLRQYATAKLDIPTSLRGAVYALACVFWKQDATLARIPCPFEQHELVNHAQEALRRELEAPNLSRLMSALLLMHMVPPDIDSVETPYIWVMACQATAIAQMLGLHQDPDKWNIAPWEKRLRKKLWWAVFYTDCWSAVSHGNPPHISYESFTTPPPDMDDLRSGEDIPDDLRYMIDPEDATFRVSDGARFLEMITVSREMRAILDCSFGVRSTQQTRTQLIPIRDTLKEWPSLIPSCLAVRPYAHNGPLHISFFATQVLLFRGLMFPATRAAKVTPGSNLQRWLSTALAEFELFTTFMAYITEEELTSFWGRFARTQLILCGNFLIYLFLLASDPRDIEAAYRLLEKFHSSLQRLGGTDDIAARVFLRPVILRIDSFFMQATELIKHGRTVVLEPPITTVPRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMZ3</accession>
    <name>S0DMZ3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424004.1">
        <property type="nucleotide sequence ID" value="XM_023577140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMZ3"/>
    <dbReference type="STRING" id="1279085.S0DMZ3"/>
    <dbReference type="GeneID" id="35395064"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01579"/>
    <dbReference type="HOGENOM" id="CLU_025210_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="433"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="538" mass="64361" checksum="797539E89BD102FF" modified="2013-09-18" version="1">MSRSSYSYDDEDDYDIRYQKRGPSPGIRYVANPQRTQNYYDAPPGPSYIGADRLNITTMHRSRSRSRSRTGELSRTRERRASSPPAPVPVIINNKIYNDLSSDDEDTRRKQVARSSRRRRSRSRSRSSSSRSRSSSYMTREEWEAEKTRKELEDLRLKTAREKEERRLVKQYRDEWEAEQARKDLEKNRLASSRERDERQREKDERQLVKGYREEWEAEQSRKELEKMHLAHARDDEERRRLREFKEEEELKQAKRELEKIKGRKARADEEERIKKEIELRRLKEEDAATEERQRREKEANSAVEDYKRRELERAAKEKKLKDQKEKEAAEAVERYKQAEKDRIAKEKADREAKDREYQDRLKQDLAKSGLDDKTIEAILKKEKIKKAQPQHPQPLPHHAMAGPAHHYAPMPVAVNQIATIPPPPPAGQVARPTYTRMSRRHLSIESLREFGVEFDFDTDPDYLLIRRWVPEWEQDRLWKHTKLIREKRTKMLMVEEKRHGREEPDFEWVRKKDKDKHSRRRSKSPGLLMYLAGARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN96</accession>
    <name>S0DN96_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426001.1">
        <property type="nucleotide sequence ID" value="XM_023571749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN96"/>
    <dbReference type="SMR" id="S0DN96"/>
    <dbReference type="STRING" id="1279085.S0DN96"/>
    <dbReference type="GeneID" id="35398389"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04908"/>
    <dbReference type="HOGENOM" id="CLU_061288_13_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071341">
        <property type="term" value="C:medial cortical node"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="147" mass="16377" checksum="344388292154EB2C" modified="2013-09-18" version="1">MSSNKFDSQASTNYKEAFALFDKRGNGRVTVDSLGDLLRACGQNPTLAEIQDLEKNVGGEFDFETFQRVLNRPGGFRDPGEPEEYCRGFQVFDKDMTGFIGVGQLKYILTNLGEKMTDEEVDELLKAVDTSSGQVNYTDLVRTILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNA4</accession>
    <name>S0DNA4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426130.1">
        <property type="nucleotide sequence ID" value="XM_023571904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNA4"/>
    <dbReference type="STRING" id="1279085.S0DNA4"/>
    <dbReference type="GeneID" id="35398251"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04770"/>
    <dbReference type="HOGENOM" id="CLU_006320_4_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="719" mass="80398" checksum="CEDF835E2CFC2729" modified="2013-09-18" version="1">MFLAYMPPKSLYDGPRLNNIQGKVAELRLELNSGGKKDKAYTGKKIALKKIVANMTMSNNDMVALFPDIIGCMGIQSLEIKKMCFLFLVNYARIRPEIAVKAIPVLEHDMEDHNPLVRALALRTMSYIHVREFVEATVPIVKHMLKDNDPYVRKTAAFCVAKLYDHDRHMVENSDLIDRLNSLLRDDNPTVVASALAGLMDIWERSDAIKLTIDYSNASKMVAILPDCSEWGQTYILEALMSYVPQESGEAILLAERISPRLSHSNSSVVLTCIRVILYLMNYIADQKQISALCRKLSPPLVTLLAKGPEVQYLALRNALLILQRRPEVLRNDIRVFFCKYNDPIYVKVTKLELIFMLANEDNIDEVLTELREYATEIDVHFVRKAVRAIGKLAIKIEPAARRCINLLLELVATKITYIVQEATVVIRNIFRKYPNQYESIISTLCEHLDSLDEPEAKAAMVWVIGQYADRIENSDALLEDFLYSFAEEPVEVQLALLTATVKLFIQRPTKGQELVPKVLKWATEETDNPDLRDRAYMYWRLLSTDMNAAKQIVMGEKPAITAESERLDSTTLEEMCLNVGTLATVYLKPVQTVFRSARPRKLQDSPALQKQNLLVAADSQKSISMFGNAGAATDIDPRSRNPTSGNGQGDLAQAVNDADAYFSSIGTQQQMQPMHDQGDDVFGGGNGHSTGYVVSAHAPQAVLQPAQGAGSNGDLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNP1</accession>
    <name>S0DNP1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable BRT1 protein, down-regulated by mating factor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426290.1">
        <property type="nucleotide sequence ID" value="XM_023572103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNP1"/>
    <dbReference type="STRING" id="1279085.S0DNP1"/>
    <dbReference type="GeneID" id="35398074"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04593"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="173" mass="18928" checksum="5E3BD22D5817A9FA" modified="2013-09-18" version="1">MTLSTRCIAPVLSILRPAAHIPQINIHPRTFNYGCSRAFSASIRSFAAMEHVFSPKAVAQVPAIGPYTQAIKANGMVFLSGQIPADSQARLIEGTIAERTHKMCQNAKAVLEEAGSSLDKAVRVTVYFQNMDDMKEMNEVYAEYFPHKPARSACESPRLPAGASMEMDIIALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPP2</accession>
    <name>S0DPP2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_04253</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426600.1">
        <property type="nucleotide sequence ID" value="XM_023572483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPP2"/>
    <dbReference type="STRING" id="1279085.S0DPP2"/>
    <dbReference type="GeneID" id="35397734"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04253"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000697">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000525">
        <property type="entry name" value="Serine/threonine-protein kinase KIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="7"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="390"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="490"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="659"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="306"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="540"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT64519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="719" mass="80920" checksum="2F223D625A1AC457" modified="2013-09-18" version="1">MSSEDKYETLEKIGHGSFGIIRKVRRRTDGFIMCRKEISYLRMSQKEREQLHAEFQILSHLRHPNIVAYYHREHLKVSQDLHLYMEYCGNGDLGRVIKDLALKGQRAQESFVWSIFSQLVMALYRCHYGVDPPEVGANVLGLTQGNAAGGPKVPAGTMTILHRDLKPENVFLGEDNSVKLGDFGLSKMIKSHDFASTYVGTPFYMSPEICAAEKYTLKSDIWSLGCIIYELCAREPPFNAKTHFQLVQKIKEGKFPALPDVYSPELYQVIKDCLRVNPDRRPDTSELLNLPVVKLMRKEKEVVDLNKSLRLREDALRKKERDLNERLANMEREKDVIREELDSSLRREWEVKARLEIDRLANAEIEQLQSRFEAEVQARVEAELQKKTVTFSGSRPESREDEYASSMGKSDYKSDYPHSSIGGSEVEFPSTTDLTEYSIDSPEAPRETKKTARTPFSRAQTMFVGNPAGTPMDIEMNSPSPIAIASLSLSPRRNGNTKAPTTANANIFTANANRNSADSRWDHPRDTLSDSEDEDVVPSPTRNIKSSKNPFTSKTRPVLTSQKSCPMNRLKTQPSTSGFVSKQMPPPEAPRSPTRRLSKIPSAANLQSEANSQGLTRASSLNNKKNSSSTDDVLGKVAAKNNIRGRTLVELQQARAGGRPMSAIVMPSTGENVSPKRAFRDRIGIERKSSGDEPVAVWDPERDEMPSPFLVRQRRIARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ49</accession>
    <name>S0DQ49_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_00718</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424784.1">
        <property type="nucleotide sequence ID" value="XM_023571940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ49"/>
    <dbReference type="STRING" id="1279085.S0DQ49"/>
    <dbReference type="GeneID" id="35394203"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00718"/>
    <dbReference type="HOGENOM" id="CLU_087648_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="164"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT62703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="213" mass="24734" checksum="553B046CBC3EEA3B" modified="2013-09-18" version="1">MTLYYTLVFMLLVFEMALFMLLIVPMPFNVKRKIFTFISENPVVAKIQYWMKITFVFILILFIDSVNRVYRVQLELAAASEQSKQGGGAAVMGHERLEVQARKFYSQRNMYLCGFTLFLSLILNRTYVMILEVMRLEDKVRDYEGTKSNTKEAEKLAVAGKPGELARLRKELEQKDQDLKTLKKQSEQLHKSYDELSDKYAATQQTGESRKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRB1</accession>
    <name>S0DRB1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to ketoreductases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425149.1">
        <property type="nucleotide sequence ID" value="XM_023573422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRB1"/>
    <dbReference type="STRING" id="1279085.S0DRB1"/>
    <dbReference type="GeneID" id="35393807"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00322"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="267" mass="29299" checksum="7B22A8DB8609E3AB" modified="2013-09-18" version="1">MEALKGQTAFITGASMGIGEAIALALAEHGVNIALVSRSKDKLETVRDKITSKFSEVKVGVYPVDIQNQPDIEKAVKSAISELGQIDILINNAGLALGAPGRFWEIPIDQVAQMSNTNINGVMFTTHAVLNHSMWKRKKGTIINVSSVTGLECPPFNGEAVYHASKAFLEGFSNSLRMETAGSDIRVLVLRPGVVQTHFHLQRVQYDQSAMDDFVEGYEPLVAEDLAQSVLYMLSLPPRVSIKALDCVPTAQRALTNFDREWNSRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSG8</accession>
    <name>S0DSG8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425584.1">
        <property type="nucleotide sequence ID" value="XM_023573212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSG8"/>
    <dbReference type="STRING" id="1279085.S0DSG8"/>
    <dbReference type="GeneID" id="35393995"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00510"/>
    <dbReference type="HOGENOM" id="CLU_027981_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053238">
        <property type="entry name" value="RING-H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155:SF627">
        <property type="entry name" value="OS06G0192800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="352"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT63503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="590" mass="66296" checksum="15E43F36C1C2CAC1" modified="2013-09-18" version="1">MSLTEIRNVVLLFSNPVWSGASTVPSTIIRNLTALSSDIAYKERISTNITTLTSTNADSSNGLITGLLYVPDLDNDRECDQQQYQFIPRNVTRRDNLPPTNYNLIALAPWFSIDCTLAYLASARLDPIRAFIFYKPNNSSNQPQDADSPVWNLEDGGAWMTVNKYPIYAISGQEGQNMMRQLSYYSGSVDDIPYGENISTLYGPNPKDYVRIWTELSVQDESDIPPLWAFFLIVIGALLAIFAFVSITMHLVQRRRRISLRKRVESGEVDLEAMGIKRLTVPATHITSFPLFTYNADPDSAAPPPTPSSTRRMRSSRGFDQRSIRSGASVRSKRSNIGASGDNAATNFQPSCHICLTNFEHRVTIIRELPCGHIFHPECIDEFLSKNSSLCPMCKHSMLPRGYSPRITNGMVRRERALRKLRQRVDLEDLSEEGDNTTMKDWSKRLFRTSPSPSRPSSSPLVNLKLPNFRRQPATNTATNDEGRVESPPASSTPAQSQELEPEAEANTRPPAPAQIPKTRRPRPRLLNMLPTQPENSELNTDPTPRRGSPSSFARQRMREIAAKNAPFDDPDSQRAIWLRALSKVFPGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT54</accession>
    <name>S0DT54_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427666.1">
        <property type="nucleotide sequence ID" value="XM_023574285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DT54"/>
    <dbReference type="GeneID" id="35396023"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02541"/>
    <dbReference type="HOGENOM" id="CLU_1004882_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT65585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="298" mass="33533" checksum="D5232272E6567250" modified="2013-09-18" version="1">MSNSEIDLDLTETHFDFFCKVGGTPQMLHALIAAQEDDVRRWSSCPSFGPFIHKLFIQPHDISRLGLIHPIGCISIEKCGRSSCLGAVEVPIDGAASITLHRPSDGEPFPFPIRYILAKFYEYGQYELHKVRMAIRFDNKTIKYVDVQAFPSENFPEARNKNQLQKFNAADGLKYSYLELLNGRGSVEFNTETAFQEHLEVIGNRMRDNGYNIKIHVPDEVIASEVEKLERFASNFDYGSFNLGAYMDMYYFMPLISGAVFGAIKNGEFAIFELDGTGDVRLRRNHQKAVGAPPGAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT67</accession>
    <name>S0DT67_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to finger protein AZF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT65646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023574357.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1279085.S0DT67"/>
    <dbReference type="GeneID" id="35396088"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02606"/>
    <dbReference type="HOGENOM" id="CLU_028814_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000260">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT65646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="496" mass="55464" checksum="78EC827E1C7FCC6C" modified="2013-09-18" version="1">MALAAQSSDAPNWGRWSQQLPGDYTMMESPHMIPFDSRATTTGPLQRPVMTPYMVQPPYSSGPVNSLTAPHYQVPNPYQFGGYQGPPTPPHHSTPFKIEYNDRRPMGHDNDHGRIPSYSREMKYTYAEQAPSPARSDSQASTVRSSCTNPSMGSKTITSNETLNPGDQINFETEVDELMKAIQRKADLQADTVQQPLTPGMSPVSEASFESQGTPGPMDSKTSRKRYRCDGPNCQKSFTQKTHLDIHRRTHTGIKPYNCDFPGCDLTFSQLGNLKTHRRRHTGERPFACDKCDRHFAQRGNLRAHLQTHQGLKPFVCILDDCNKTFSQLGNMKTHQNNFHKKTLKKLTMKFAKIIASGEEVTEADRELFEYFATHYKNSNKGIKGRGKARTVAERKTKASQSPPANTMTAVPQYPLPQIASTPVTPHGLPVSGSLASYSVTRGHPAPINQMSRQTHNGGYEVYDMHGHHHIQPPNNNGMLYATGSTREMGYHGRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTA9</accession>
    <name>S0DTA9_GIBF5</name>
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        <submittedName>
            <fullName evidence="4">Related to C.elegans ZK688.3 protein and E.coli hpcEp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023574569.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1279085.S0DTA9"/>
    <dbReference type="GeneID" id="35396277"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02795"/>
    <dbReference type="HOGENOM" id="CLU_028458_5_0_1"/>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="235" mass="25282" checksum="10EFDE80BFD2A350" modified="2013-09-18" version="1">MAPQATSSLKQAGKVVCIGRNFAEHIAELNNTKPKQPFFFLKPASSIVLPGEGPVLRPKGIDMHYEVELALVIGKLTRDLQASDTQGALDAIKAYAIAVDFTARNAQNEAKKKGLPWDIAKGFDTFLPLSNIIPKTAIKDPHNVELFLQLNGETKQQGSTNLMIYQIPRILSDISKVMTLHPGDIVLTGTPAGVGPAVPGDVVRAGVRIDGKELEEGAIEIPVEESPSSYSFAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTJ8</accession>
    <name>S0DTJ8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LPXTG-motif cell wall anchor domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427980.1">
        <property type="nucleotide sequence ID" value="XM_023574666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTJ8"/>
    <dbReference type="STRING" id="1279085.S0DTJ8"/>
    <dbReference type="GeneID" id="35396365"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02883"/>
    <dbReference type="HOGENOM" id="CLU_003899_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1165" mass="125341" checksum="AE073C069D9C8362" modified="2013-09-18" version="1">MTVKGGFTSAGQPGPDSQHQHQEPASGNMPFPMATADLQSDASSSTVIAHADSHRQSHSSSKLPAFRFTDRRSSSCGSVPLAHKGDPLSLSSSNQYNHNRNQNLDSRNNNKDGRTDDYLDHKPTTLASATVTASASTPTSPLANTLNSASAALPLQSSIVPPIVSHNSDPSTITPTVSVAPTTVSPVSAEPGPVPPPSATVSGPLTAPDPGTAPATLATTHSHTSHPTTHHCDEKHAVSALTSAPASASAPTDPSTNTASSFSQPNESKSSYESDTTLLSQTNSKTSSVHPSSSVIQLSPGVKRPASFEAHAPDAISPHPAPPTSKSRTRRPLVSRRSTAGTSSTGPPPSLNSERLQAIEAAQEGQSTFPSSSDNSPQQSPSGQRELILPKTLSRTNSDERRASASHRPPVSYRPPLTSNSSTDSSPSTAVRVPPIRSFRSSGSRKSLTLDMNSRPRFHDSGDEVEDTNHDRTLRALEGRGNDDALRSAPLASSRRGAFDNEDTGDVFLKIAREETSQRQTDEQSQEDTRSVVSRSTRFTHRRPLSSVVPIHQPTSPPRVRRRLSDQQDTARSRSRGYEDDRATEISRMSTYRTLPREKAASAHPGEDTGRLRGSTSTMRPSPVTPRSIVFQEPSSENSMYSRRRSSVTDNNVSGQNRGSAYKFMGHGHNKTYNSSPLVRSFDFQRQANQEAGNGAEGTESTLSNTAPSTVWDELDDLKSRIHRLELTGKLPSTSGAAVSRLSDDRPPTATTTATTMSSSPKRVENGHQNTNADAVSTTSSHHRESHSILQSALAKSKVLLDTEVYQALESAANDAMALASMMGTPGLPGPISSGASTIGSNATVTDRQLRRKAESVCRSLTELCLALGEDATQTRVPRQSIEVPPPAQNDAPTTPTIGKTFSGFSQRRQSIGRNDQGAAKEHLTSPRTLSKFEERRLNILNGSSLPTTSRVSNSIPSTPIEPISNRRSSLLVSRSRRAGTEEPDEGRKSSLLLRTRRAGTEEPDEGRRTSLFVRNRRNTVGEEGEEESRFRAPSRAPTELGSTIRVVTQDQTPQQQQQQQQQYSPSADTTSAIPRRRFVSSNLGVSRLATPSVNTATPPRRYMERPAQQEQGHGAVDKLAEERAQRYTSLGQTTMVNRTSSMIRRPKRDSIASANPSAAAGSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTW3</accession>
    <name>S0DTW3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_02867</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="9"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427966.1">
        <property type="nucleotide sequence ID" value="XM_023574648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTW3"/>
    <dbReference type="STRING" id="1279085.S0DTW3"/>
    <dbReference type="GeneID" id="35396349"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02867"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF4">
        <property type="entry name" value="D-XYLULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="63"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="215"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT65885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="398" mass="42647" checksum="7F4C362E1AD8F4D9" modified="2013-09-18" version="1">MCSLAASQPLTHDVAPIVDELKVMLNGYSSDTQTLKAPLPNPSLQVTADHNLKRVDAPVYAPKPGEVLVHIKATGICGSDVHFWKTGCIGSLVFEGDCIIGHEAAGVVIRVGEDVADLQPGDRVAVEPGVSCGHCFLCKDGRYNLCEDVQFSGVYPYAGTLQRYKVHPAKWLHKLPDSVSFAEGALLEPLSVVLHGINSAPITLGTPAVICGAGPIGLLALAAARASGAHPLAITDVEPKRLAFAKEFVPTAITYQVDISKSNEQNGKSVRKLFGETEYVQPRVVFECTGIESSVCSAAYMVRRGGVLMVVGVGRSIMNNLPFMHLSLAEIQLRFINRYKDTWPAGIACIEGGLIDAKKLVSHVFPLEQALEGLSLSADPKNGCIKVQIVDETETTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU14</accession>
    <name>S0DU14_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_03027</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_023574827.1"/>
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        <property type="component" value="Chromosome III"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
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        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
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    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="489"/>
            <end position="593"/>
        </location>
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            <begin position="1"/>
            <end position="27"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
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            <end position="364"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
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        <location>
            <begin position="470"/>
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            <begin position="552"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="7"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="15">
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            <begin position="39"/>
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    </feature>
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            <begin position="82"/>
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    </feature>
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            <begin position="486"/>
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            <dbReference type="ARBA" id="ARBA00004567"/>
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            <dbReference type="ARBA" id="ARBA00004620"/>
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            <dbReference type="ARBA" id="ARBA00081079"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT66034.1"/>
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    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
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    <sequence length="711" mass="69153" checksum="79DFC8F7D3FA1D49" modified="2013-09-18" version="1">MSFSFGNASSSSAPNNTTSTAPASGSLFGAATGTPSFSFGSIGGSASNTTTPTSSATNMFGQQSGASAPKPASNLFGGGANAINTSTTPSSGGIFGAGGSTTPATGGLFGGASSTTPAATSAPSSGGLFGGGTSNSTAPASSGLFGNNGTNANKPATGLFGGGSSSTTTSNGAGLFGQNNANQAATATPSSAPTNLLGNAASGAATPAKPTFALPSTTPAGAPPADSSKPAGGLFGNTGAQASSGNSSLFGGAKPASTSAPSAQPSTTAAASPSGLFGGAQSGSAAPTGGLFGAKPASASTPAAGGLFGSKTEGAPPAATSQAGSTASLFGAKPAAPATTTPGSTPASGLFGGGATTSAASGASATTTAGGLFGNKPATTATSTAAPATTSASAGSLFGGAPKPSTESSTSKSAGGLFGAPASSQPAGSAATTTATTGATTTTTAPAVGSTPAAASSLFGAKPATDASKDAAKSATSSATPGALGASTTGPTSQMARLKNKTMEDIVTRWASDLSKYQKEFKEQATTVSTWDRSLVDNGEKIQKLYLDTFEAERASHEIERQLAAVESQQDELEAWLDRYESEVQDMFAKQLGPGEQLAGPDQERERTYKLAEKLTQQLDEKSRDLSKMVKEINDISGTLNKGAKPEDPLSQIVRVLNGHLTQLQWIDANASSLQAKVAAAQKSSSNLGSHYAGSDNDAAESFYRSYMGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUL6</accession>
    <name>S0DUL6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_03117</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CCT66120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023574928.1"/>
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    <dbReference type="HOGENOM" id="CLU_001042_5_0_1"/>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="11">
        <location>
            <begin position="522"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="323"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="399"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="736"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT66120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1201" mass="137084" checksum="F368440E6A1E2386" modified="2013-09-18" version="1">MYIKQIIIQGFKSYKDQTVIEPFSPKTNVIVGRNGSGKSNFFAAIRFVLSDAYTQMSREERQGLLHEGSGSAVMSAYVEIIFDNSDDRFPTGNKEVILRRTIGLKKDEYSVDRKVVTKADVMNLLEAAGFSRSNPYYIVPQGRVTALTNMKESDRLNLLKEVAGTHVYETRRAESLKIMNETNNKREKIDELLEYIKERLSELEEEKEELRAFQDKDRERRCLEYAYYHNIQLGIQANLDELDNARQDGIDSSDTNRAEYADGEKAISRLDSEIHKLQREMELLQIERRQVEEDRRDGAKALAKAEMKVKNLREGQSAQEQARTQHAAELESVQNEIASKEQQLSTISPAYNQKKQEEDEIRRQLDHAEATRNRLFAKQGRGTQFRNKSERDAWLRKEIQELELNISTQKANKIDADEEVERVQQSIAQAEQDVADLRSRLANFPDERIALEEEAAKARDIIDKLNDERKLVRREDDKLNSVIANARQEKETAERELAHAMDGSTARGLATIRRLKQERDIPGAYGTLAELLEVSDAYRLPVEQIAGASLFHYVVDNADTATYLADTLYRQQGGRVTFMPLAQLRPRQIKLPRSNDAVPLLSKINFNEEYEKAFQQVFGKAVVCPNLTVASQYARSHGVDGITPEGDTTNKRGAMTGGYIDPRKSRLHAVQAVNKWRDEYERLLAQSRDIRKQTELKDQEITAAMSDLQKANERLRQAVDGVEPLNHELFNKLKHLNKEQSHLEAAKKRRDAVEKNMNSFLEDLAAHEAELGSDFKKTLTAAEERQLEELGTSTQELQKQWNELSRARRDLERQKQLLEVDLRQNLQMKLDQLNSQAFEDSTGSSGGGLKDAQRELKKAQKAQKAVEVSLQELETKMDDTQARLEELANEKAQLEQVQSEISARIEKQQKKMDRSLRKKAVLSTQAAECAQTIRDLGVLPEEAFDKYENMDPNQASFVSTKIKKVNEALKKYKHVNKKAFEQYNNFTTQQDQLMKRRKELDDSQESIEVLVEHLDRRKDEAIERTFKQVSKEFTTIFGKLVPAGHGRLLIQRRADRRQEPVDESDGEVRGVENYTGVGISVSFNSKHLDEQQKIQQLSGGQKSLCALCLIFALQATESSPMVIFDEVDANLDAQYRTAVAALLESISKEIGTQFICTTFRPEIVHVADRCYGVTFRTKTSSIDCVSTEQALEFVEGQAKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUP3</accession>
    <name>S0DUP3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428262.1">
        <property type="nucleotide sequence ID" value="XM_023575004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUP3"/>
    <dbReference type="STRING" id="1279085.S0DUP3"/>
    <dbReference type="GeneID" id="35396668"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03186"/>
    <dbReference type="HOGENOM" id="CLU_098340_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26972" checksum="46D75CA0EB08963C" modified="2013-09-18" version="1">MSTLRPLRGGCQCGRNRYIIAVPQNGINEAQVLFNTESAHQIPLATPLAAYIRVPLSWYHSTTYSFFPDETHALIRRVYTHPSQQYSKRHFCGYCGTPLSYWSENPHTEAEFINLTLGSLLREDLRDLEDMGLIPEEEDDKAPAGRSPAVVGRNTALRQSYGVPWFDGMVEGTRLGNMRRSQGVKQSHDGQVKVEWEIVEYSNGDESKAPAEEDNDVEMSNPGKRKLQDRDDLEAGAVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVX4</accession>
    <name>S0DVX4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to tol protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428701.1">
        <property type="nucleotide sequence ID" value="XM_023575534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVX4"/>
    <dbReference type="STRING" id="1279085.S0DVX4"/>
    <dbReference type="GeneID" id="35397143"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03662"/>
    <dbReference type="HOGENOM" id="CLU_002639_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="198"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="631" mass="72084" checksum="5F6DF19A469CB356" modified="2013-09-18" version="1">MTLCSLCRTIPFDKLPTVPQDIKDGYMTGNPYIQHFRGWPPEDKGFLHYQSLDALQRSASELQCLLCNLILEQVLLCQAELEKLKLAWELNRAYEYVWPLWEFWLIKPASGRDGFWVMTFTDELGFKDEVRRREARLVAAIGLCVEDGMVTQYNQSDSIDIISPTQTFLPTRVIDVGKELNSPYVRLLETQEHDAGRYVALSYCWGEMPQFTTTRSTLQERKDGILVASLPKTHQDAIQITQMLGVRYLWIDSICICQGDKEDWERESAKMLSVYANSYLTIAASNGKDSHEGLFNEIPAIKYVQIDLVFGNLQGQALAFSLPLQEESFSTGCLMKDNRPTFPLFVDYITLPKEPLSRRGWTLQERVLSHRTLHYSSRQMLFECNEAFRGEDGLFFQARFDTIHQKGSERDAAAIDHESEHSTYKDALLKSWYRLVQLYGQRHLSVPSDKLPAISGLASIFAERLGDQYLAGLWRSDLMVGLCWQDVEVTLKGANPYGEVLEGKIAICAPMERLCPVRGESTQPVEFELRVENAQTVRTMCCFDSIEFSEDLYKEAGGIPENIQGREFFALILIELAGLRDDNLPFLGLVVERIKGKEEYQRVGNFRTSGKALRKETKGREKDRAQSITLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWD8</accession>
    <name>S0DWD8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to beta-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427788.1">
        <property type="nucleotide sequence ID" value="XM_023574435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWD8"/>
    <dbReference type="GeneID" id="35396158"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02676"/>
    <dbReference type="HOGENOM" id="CLU_023475_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="183"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="501" mass="55419" checksum="75557A19658D6948" modified="2013-09-18" version="1">MSTIQSQSSPATLLWDHQDLIPLQKNLGDEDLVLLLTPAVVPLDQSLANASDPFEPLGKALARTHPWIRHVPYTKERGITGIHVAFIKRARVVIFVLTGFSTEEGLFQLELAEVAREVCEERPLVLVACCEVSEKGAREYGFPTIIQCPGYFAADLQAVAVLLTSERPATEATPPTGNSPPPPTWSLLKWDYDKDLPETHSLWEACLPSKFYLNRSTLGSLLKRDGYAMHYMVREPNQGQAVGFCATFTTFTDSSGDRLIGSVAAIIVHKDFRGQGVGRFLHNEVVSKLNKIRGVGIIQLGSTFPRLLYGLPAPEADTEWFEKRGWNMKESTPGNGRRVLDWLLRFADHPIPDLASAGLTFRPCQLIDYEKVVEMANKESQKRYGFGWYDQYAKTMDSCYMNDIVVGLEGENLVAAAITYFPNNGSPCGADIPWPASIGQSIGGVSCICIKDEDPDMVNRRDSVATRLLLACRQTLSERGMVGMFVDGSRSDENVLQSLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWG9</accession>
    <name>S0DWG9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427823.1">
        <property type="nucleotide sequence ID" value="XM_023574478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWG9"/>
    <dbReference type="GeneID" id="35396195"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02713"/>
    <dbReference type="HOGENOM" id="CLU_075891_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT65742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24084" checksum="FC0AA57AEC01F725" modified="2013-09-18" version="1">MATTIQQQQEPHKTGFLDLPVEIRLEIYDELLLTAPYTRCGRPCPEQKVHASLLRTNRQIHDEATDLLYGCNTFLSHPTLLTSFPRLRNWYGPVKESSIIPSIRRFHTQVRLDVDLPYDADAVTKAYSGLDELTIDVVQSMFLGVGYRNLRMFEGVRGVKKVNVTGSTTGFEDYVEWLKMCMMTEPGSKVPEYEPQQQAGWIQRLATVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWR8</accession>
    <name>S0DWR8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to cellobiose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_13176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429080.1">
        <property type="nucleotide sequence ID" value="XM_023575829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWR8"/>
    <dbReference type="STRING" id="1279085.S0DWR8"/>
    <dbReference type="GeneID" id="35406630"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13176"/>
    <dbReference type="HOGENOM" id="CLU_011025_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485364" evidence="4">
        <location>
            <begin position="18"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="544" mass="58379" checksum="CAAF19D33CCD4897" modified="2013-09-18" version="1">MKFATIIGSALLGFASAGNTTTRKTTYDYIVAGAGASGLVVAERLANAGHKVLLVERGGPSFYSTGNRDDLMKWNKTVTAYDVPGMAYYTDISPTIQWCTDIAASAGCLLGGSTMLNALMFVKPRAADFEGWPKGWQWEDGVSDAAKSVFEHMPGSILPSADGKRYDDGAFEVMSKFLESNGWDEVNALENVEAKDKIFTHPPWLISNGLRGGPVRDILPAAQALDNFSLQLHAKVIRAVRKGPIITGIEVEHENGSREIIKLSKGGSVVLSSGTHSTPRILFNSGIGPKKQIRIVQSGSTNVKLPPASQWIDLPVGQRLRDHPIVVVDFQTKNKLQALPKEAFTEPNDETVELFAEGSGLLSQSAQRLNFWKSVEGSDGVTRYVQGTVNAPENNTISAKVYLTHGLTSHGTLEITPEGNTNITQKPFLNTEGDRDALKTFVAELLSYARKPGSVLSVPSNVTADTILEVSYSGNHHLGSANMGAKNDGKSVVGPDTRVWGTKNLFVVDGSMHPEVPTGNTQASIMVAAAHAANKILAASSKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX94</accession>
    <name>S0DX94_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable PEX4-E2 ubiquitin-conjugating enzyme-peroxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428103.1">
        <property type="nucleotide sequence ID" value="XM_023574814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX94"/>
    <dbReference type="STRING" id="1279085.S0DX94"/>
    <dbReference type="GeneID" id="35396497"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03015"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="14"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="172" mass="19011" checksum="3CD9CF7FB4902E23" modified="2013-09-18" version="1">MPPSSSNSAAASRSASRRLIKELDTWSTEQKEEKGIERLGPVNEGDLMEWEAVINGRDIGHGYDEGRWLINISIPSTYPLAPPKMTFVTPIVHPNIALQTGEICLDLLKDAWTPAYSVLECVRAVRMLLGCPETDSPLNVDVAALLRSGDVLGTRKLVEFWCRDSDGRYEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXA7</accession>
    <name>S0DXA7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427179.1">
        <property type="nucleotide sequence ID" value="XM_023572369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXA7"/>
    <dbReference type="GeneID" id="35397836"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04355"/>
    <dbReference type="HOGENOM" id="CLU_023132_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT65098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="473" mass="51078" checksum="99B8757197628502" modified="2013-09-18" version="1">MSSDGVGGRFWRKQKLGSRDFTLQERRATGEGEVDVEAEEGSIRQGVSTEYRTYKRRWFGLAQLTLMNIIVSWDWMTFAPVASQAAEYYDHCILPCICGVFPISIAILHRGPKLAFMTAAVLILIGNWIRYAGSTKSSGGNIAYAMAGEIIIGFAQPFILAAPTRYSDLWFTNRGRVAATALTSLANPFGAAFGQLITPLMVKKAGDVSNMVLYISIISTVCAVPAFAVPAKPPSPVGPAAETPKLSLRESFGVLSRSLEIWLILVPFSIYVGFFNSISSLLNQILSPYGFSDDEAGIGGAVLIVVGLIASAISSPIIDRTKSFLLTLKILVPIVGVSYLVFVWMPETRDIAGPYVVLAILGASSFSLVPIALEFLIELSHPLSPEITSTLAWAGGQLFGAIFIIISDALVADKDASPPKNMKNALIFQAVVALTVVPLPLCLGLFGRKEKTMLRRVRSDEQNRSDTTVTTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXG2</accession>
    <name>S0DXG2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 20">Glutathione reductase</fullName>
            <ecNumber evidence="4 20">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">FFUJ_13422</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="17">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="4 20"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429307.1">
        <property type="nucleotide sequence ID" value="XM_023576105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXG2"/>
    <dbReference type="STRING" id="1279085.S0DXG2"/>
    <dbReference type="GeneID" id="35406876"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13422"/>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000671">
        <property type="entry name" value="Thioredoxin reductase 2, tandem duplicate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 20" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 17 19" id="KW-0274">FAD</keyword>
    <keyword evidence="7 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 20" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 19" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="22">
        <location>
            <begin position="9"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="21">
        <location>
            <begin position="356"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCT67226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="469" mass="50796" checksum="6A902A706B3C1120" modified="2013-09-18" version="1">MAPITKETDYLVIGGGSGGLASARMASSKFGVKATIVENKRLGGTCVNVGCVPKKVTYNAAALAEAIHDAKAYGFSVEQTAPFDWSTFKTKRDAYIKRLNGIYERNLNNDKVDYLHGWARLVSKNQAEVTLDDNSKVLVNAKKILVAVGGKPTIPPDIPGAEYGTNSDGFFDISTQPKKVAIVGAGYIAVEFAGMFNALGTETHLFIRHDTFLRNFDPMIQESVTKEYERLGVKLHKRSQASKVEKDSNGKLTITYKDDQGNESVVSDVDNLIWAIGRTPETKGIGLEEAGVKLGEKGHILVDEYQNTAVDNIYALGDVTGEVELTPVAIAAGRRLAHRLFGGPEFANLKLDYSNVPSVVFSHPEVGSIGLTEPQAIEKYGKDNIKVYKTSFTAMYYAMMEPEQKGPTNYKLIVTGPKEKVVGLHIMGLGSGEMLQGFGVAVKMGATKADFDSCVAIHPTSAEELVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXP0</accession>
    <name>S0DXP0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428218.1">
        <property type="nucleotide sequence ID" value="XM_023574950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXP0"/>
    <dbReference type="STRING" id="1279085.S0DXP0"/>
    <dbReference type="GeneID" id="35396619"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03137"/>
    <dbReference type="HOGENOM" id="CLU_051385_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="8">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="268" mass="30171" checksum="C986B67B8026313B" modified="2013-09-18" version="1">MAPQNQLGKRVKLTQVRRPFIVGSTAKPFSDTNPRPAGVPDTHTHSWQVFVKGLDDTDITYWLRRVQFKLHESIPNYVRMVEGEPGKPFVVEETGWGEFDITIKLYYVNDSGEKPQTLYHYLRLHPYGRNEEEKQAMIASNGEIRAWSYEEQLFNEPYEVFYNLLTQGAVPKGWKPSGGKGKGKTRAPPPLPTDSNEVWEHSAMIPAHNRPGQPFSLETEAAEIRKLAGAQTQAEDMAKRILAELKAKEELLAKLKGENQAAAAAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY77</accession>
    <name>S0DY77_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429567.1">
        <property type="nucleotide sequence ID" value="XM_023576416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY77"/>
    <dbReference type="GeneID" id="35407156"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13702"/>
    <dbReference type="HOGENOM" id="CLU_030508_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484642" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="310" mass="35290" checksum="6BECDAA086006462" modified="2013-09-18" version="1">MKLSSLILSAAFAAAAPLSRSTDVRLITYNIRLAPKKPQWGEELWPVRRPRLTAQINYETSGRPESIVCMQEALYPQIQDIQQDLGSEWDYYGIGRRGGQSDEFSPIFYRPSVWNIEDKKTYWLSDTPEKAGSRGWDAAFPRIVTVARFQHTATGNRMVYMCTHFDHKGKKARANSAKLITDIAENWSIHDGETIPVFIGGDLNSSPSGAAYKHLAKTMNDVKSLVPQSKRYGHSSYTYTGFTTVPWDDMYLDHIFVHDPTGIEFKAFAVVNSRYEDGVFISDHRPVVVDVRLNQVSRKQRRTGEKKDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYC6</accession>
    <name>S0DYC6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM5</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM5</name>
        <name evidence="7" type="ORF">FFUJ_13673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYC6"/>
    <dbReference type="STRING" id="1279085.S0DYC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13673"/>
    <dbReference type="HOGENOM" id="CLU_074410_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="307" mass="34045" checksum="6DD7FA83ECEEE756" modified="2013-09-18" version="1">MSFEDEEPISLSSHALAALAEFHAEKDAHEKTFEKLRTGAAPRAGAGLGVVEPEDEDPVAEDADDQPLSMAAFTEDWNESQFWVRKTTCTNNVLSSSCLAPFGSGGGDRGHGMAWHGIAIGFWDIVCAFASEVGFLDETAFALADQLLDGASSSSTIGVVSTPSVFIALKNRLRFWPIEDRPKLVLFEHDHRFSVFPEFVFYDFQRPLQLPAHLKGSLDSIIIDPPFFSNDCQTKFALTGRWLVKPKSPRVIICTGERMATIVDKLYRSLGVYATTFEPAHAGLSNHYYCYANFESSTWDWRSDVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYD6</accession>
    <name>S0DYD6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_03456</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428508.1">
        <property type="nucleotide sequence ID" value="XM_023575305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYD6"/>
    <dbReference type="STRING" id="1279085.S0DYD6"/>
    <dbReference type="GeneID" id="35396938"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03456"/>
    <dbReference type="HOGENOM" id="CLU_013022_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT66427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="663" mass="75510" checksum="71F11E322118539B" modified="2013-09-18" version="1">MANLVPPGSTRESSSSETGNIMSFNKGKMPALPYGGGPGPSISHGQIPLRPSGTISRDSSVIRGINGGFHPGAQTPMSGVTHASWLTNNGNESNLSFTSSIMQEEAKLRWDSDEELKKMSKSMLRLQKWSLIIGLASINGVLIYVGWKYYQVYYFFLVLLSSNTVLQSFMCICIILHWFITHVLLGWWKREENIPAEPEKMVLLLPCYNETYQELTRSLDSLIAQKNIDNHPRVIFIVVDGNVRGPGMEKTTQDYLLQDILEPGPSRTFENGYRARDGLFMPVKTQTGFYKGIPYVFVGKRYNQGKRDSLCFARSLIYHFKQRSENIVTMFNNELFEYIGNNFINAGLDDITYLCGMDADTVFDEYCIWEMIKEIRKNPKLVGVCGHVCVDFDGHNWGYWSLYQSVEYSQTQGLRRMFQSRITGKVNCLPGCCQLIRVDEATFGDAVLRERFGYCPKPNDIMTQHIMGNYSEDSIHASIIFSLFPGKQTAQALRAKAMTIVPQDWKVFLSQRKRWALGSISNEFVMIFRPGIILIERLQSLIAVITWAITPFIIAAFVELLIVFAKRGSEVMQDPVFLGLICVLFFRYLYSFCIGFWLPRNNLERAQYFAGYVMHLFTSPFMNIIILVYSLFHSDDFKWGKTREVVRGVNEKDGDDVGGRGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYE8</accession>
    <name>S0DYE8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_13240</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429632.1">
        <property type="nucleotide sequence ID" value="XM_023575902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYE8"/>
    <dbReference type="STRING" id="1279085.S0DYE8"/>
    <dbReference type="GeneID" id="35406694"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13240"/>
    <dbReference type="HOGENOM" id="CLU_116822_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000006">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF13">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="18">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT67551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="146" mass="15190" checksum="87E0DE4CDFE9C364" modified="2013-09-18" version="1">MASSRVFASRLASQMAVKAARPAVRAPVAAASKRTISGASPLQAMKRQTLLQATSRNAFQVQRRAYSSEIAQAMVEVSKNLGMGAAAIGLTGAGIGIGLVFAALLNGVARNPALRGQLFSYAILGFAFVEAIGLFDLMVALMAKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYP7</accession>
    <name>S0DYP7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to small s protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_02528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427654.1">
        <property type="nucleotide sequence ID" value="XM_023574270.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DYP7"/>
    <dbReference type="GeneID" id="35396010"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02528"/>
    <dbReference type="HOGENOM" id="CLU_003381_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1564"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1594"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="4">
        <location>
            <begin position="548"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1121"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT65573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1621" mass="183911" checksum="5B203483F12BB3B5" modified="2013-09-18" version="1">MPPYFGNLQGAISEYTRPSTRHLANNILCHVHYQLEDIENRFGISLGCNAFEELQRSTGLADAQLGQIPCGTEAWEEICDRLQCILSNLHHLQTALPMLCALNHSERSLRQSRISKAFEGTFSWVFQEQADDAIHVQSLLRRWLISDHSLFWVTGKPCSGKSTLMKFVSEHQDTRNLLQKWAGHRELLIVNHHFDATGLPIQRSFEGLLRSLVFGILSAKPNLLKNSPSSLGSASSTLPATFKLGHILSSITKNNVPVNMCFFIDGLDEYEGDNAKLCQLIEDLSSLPHVKVIVSSRPLAVFDDSLNISSEAKLSMEEANRGDINRYITFQLEGSHLQSYMDRSNYRDLDVESLGAQAQGNFLWAVLVTRFLLEEPSLLLDAYNGAENVADIPHNLPSLVKSVTKSSNFQACGKAAEYLTITREAKRSLAAEILYFHNFDFGNDMYAFVTPTDLLSPHDEKTKQLHHQVHRDIIQTCRGLLEVVDGQVAFVHRAVLELMHSEEFHNYLLTKVRKGFDSDLSVFKASVSWLKRKSFRSGEFIDLQPEPAAVSLAYVKSLSKFHKKLASTLPDFQDTFNQPVDVYWMTKVVNIRGGFRNVCKHEIWLDVVKDLGYSDDTAISVSDSLKKLYERWLHPYEEHLHQKKLEEHDPMKDIEDLVQSLRKCLEYARRCDQKENTVATTWALLDNIEESLLSMTARNQFNISDISMTRGIYRHLVIESGIQRYIANKLWVDPGYCDNKYSQNYRSPLCSALGAASHNLHPAHLSPESIDMSLFKSLLALGHKPNKFHLTGETPWVTFVNTHVPDTLCNSFPRLGQEIMLNFWTRNRGRGKFQFGSSFSCWLIGYRLLNMPMFERVFSMMLERAPHIPDSRALLELKSDGETYEWIPFPLWAISADNFALPNVSDSSLSDADFVFRVFAGVCEKNLDNLEMSERSRKYLSSYFLPDYPELGRQILMLIPGSDSRTIGFTTITSATRDRNTDSISGRNSTVATSIELPEGIEVESTKEGAVCNSTRAEVDAIMDEVGSIQSIEEDIQSHNSSIARTPVIIAAERQIGDLLSRHPDLRFIIDISSELMPKERLERNVRRSLKHLYLKLREYTEKNIETQVLTTRMLKGRRSRTRISKRAVDGGLATSTPRNSNEEDEEIRPSFRKDRAYLNNWILKTELSARPDEKPQQPADETSDTKLTEDNDDVYDEIESDSGDFQAVQIAEEFLLKGPPFRAFLGHLGLSLLPDTLRQVMQLAAWDTIEMIDTPAEVSISDQIKLAAEKATGSPWDWWPLKPPEVPLPRGYVRMNWACHCGKPLSIDITPSQAQVIERMTKNHTAFAEDHHKVAHTRRNIFQGFTAWFKWNSGALLPVSTPVSQGSQQPPGVGGNNRIQQGATTTEQNNIPPVAIHDLRILFGVPMGLKTLHVIPIPVHQPDSNVFTQLKAEYLKTRGRWRAWFSFWQLSHCNFVKFESITRNIVVACGQDLPKASDLDYDYAPKPPQASIPPVHPHIFEAAFNSCTGGKCRNLSPFHDCYEFEETTYIKRIPKKKTPLSPGTIDIPIWGLEARHCISCFHVIIYHLLILIPPFVLWGWWMSRHPDDIQSASVPMTIVLAMISMFWSATGIMKQFRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZC2</accession>
    <name>S0DZC2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428828.1">
        <property type="nucleotide sequence ID" value="XM_023575467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZC2"/>
    <dbReference type="STRING" id="1279085.S0DZC2"/>
    <dbReference type="GeneID" id="35397083"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03601"/>
    <dbReference type="HOGENOM" id="CLU_071331_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="324" mass="37207" checksum="99115DBAF78AA029" modified="2013-09-18" version="1">MSDYLDVHKQQHFFSVEKNPEELPFLNAMLTVFNRLGHLDVVDHAYNYPHLHLAAFYGWHDVIEALLNWGSNPDVQNSEGFTALHVACASLDVKSTKIVQALMETGADPNLKTDATEFAPIHHLIEASRNAAEPWDCIGKLETLLKGGADINASDKHDRTPIHLASCIPWCNSIFDRLYKRGARLDLLDNMGKSILHYVALYGDLDHITYLRKHGLTEPDPDGKDSSNRTPLDLMLWRRNAKLENLRKNMKRPNDEEVKAFNSLIEEIKIHRWQDGRSCWREGEHANHLKLRKQRINLPIRPKPTLTTPPSIEQEMHVKEQWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E002</accession>
    <name>S0E002_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430196.1">
        <property type="nucleotide sequence ID" value="XM_023577070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E002"/>
    <dbReference type="GeneID" id="35400357"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06880"/>
    <dbReference type="HOGENOM" id="CLU_741961_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="405" mass="44852" checksum="CEEB487E842AFC7D" modified="2013-09-18" version="1">MSALAEKIGTKLLVKFACGIAGAAGAKAFEKGFEEFFGSDEGNIKNEIADVKKDLKEAIGLIRDVKKSIDNLASQLADSILQLRSDSLKSHLTKIDSLYNGIIDIFETVVRDSEIADLEKRQEKMRDLQKRLDNRLKEAVKEVPESLEQINSFLGEEGKSSFLQQLAQRAFDNSEEFRIFYLRCRALVYSYWAVVGRGIELLEMATKSPKVHFSEGEKTTARHLGYLEKQQQLFESSVGKATIDLYNSLMEVEGEMKLPIWFATGDGSGLGKVSHLIPSTPIPIASGGWQKWHLIPASGRESLDSFSGSAYWLQEIETGDYLGIVTAGGGYNSARFVVKGHGLKIPVQWNWFIKPAAPGSDRFTIRQEDSPGWVIGVDNVTKALGMKEPLPSPSAELFQILPLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E090</accession>
    <name>S0E090_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to DNA polymerase delta subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429128.1">
        <property type="nucleotide sequence ID" value="XM_023575885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E090"/>
    <dbReference type="STRING" id="1279085.S0E090"/>
    <dbReference type="GeneID" id="35406680"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13226"/>
    <dbReference type="HOGENOM" id="CLU_077732_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="203" mass="22653" checksum="FAEDE1522C3A7EF2" modified="2013-09-18" version="1">MPTTRRSAASTRSRGPPAKGQSTLSFSNKVTKPVPKSAKKSAISASISKLDPDQHATQREVEDIVVNNHESIEIDKDEEVEAVTEIEVVPEPARSELELQAEKVTDAQIKKYWKSIEDQWTTPRLHQQGVSLNEKVLRYFDVSSQYGPCIGMPRIKRWKRAERLGLNPPIEVLAVLLKEESKGNNKIETAHMDEILNSTAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0F5</accession>
    <name>S0E0F5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable panthothenate kinase/uridine kinase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_07126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430429.1">
        <property type="nucleotide sequence ID" value="XM_023577344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0F5"/>
    <dbReference type="STRING" id="1279085.S0E0F5"/>
    <dbReference type="GeneID" id="35400603"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07126"/>
    <dbReference type="HOGENOM" id="CLU_067202_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="236" mass="26659" checksum="F61BD904870D4AC8" modified="2013-09-18" version="1">METQVGRLVEKAWKKFEETPKDKRLLIGVAGIPGSGKTTFSQIITDRINARASSSDPSSPPPATFVPMDGFHLTRAALSAMPDPDTAHFRRGAAFTFDAPKFLTLVQALSKRPIPSEPILAPSFDHALKDPRDDDIVVKPEHRVVVLEGNYLALNQDIWRDAAKLLDEVWFVEVDFEVARRRLRERHVRAGIVKDLEEGDRRAMENDLVNGKEIIDFRLKVDEVIQSREDGSWVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0J7</accession>
    <name>S0E0J7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to anon-37cs protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430464.1">
        <property type="nucleotide sequence ID" value="XM_023577385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0J7"/>
    <dbReference type="STRING" id="1279085.S0E0J7"/>
    <dbReference type="GeneID" id="35400640"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07163"/>
    <dbReference type="HOGENOM" id="CLU_004498_7_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF414">
        <property type="entry name" value="CONTAINING AMINE OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="539" mass="60458" checksum="CE8054BE9F7E9A6A" modified="2013-09-18" version="1">MDAYSICCTSPAARHTSKIYQDLWSTRPHTRVGYDQDKILKKFVTMDSLKQRWGGDQTSKPHIGVIGAGLAGLRCADILIQNGFRVTIIEARNRVGGRLHQEVLPNGHLADVGPNWIHGTNDNPMLDLAKQTNTAISDWESTSCVFDESGELLSLKDGEKYSTIMWDIIQDAFKHSNSNSSAIDSKESLHDFFVQKVVERVPDTEADHERIRSIVMQISEMWGAFIGSPAYRQSLKFFWLEECIEGENLFCAGTYKKVLDEVAKPALGGAEIKFQAKVDRISYRSNPEEKAKVTTESGQTLEFDEVVVTAPLGWLKRNLDAFEPALPARMTKAIDAIGYGCLEKVYINFPNPYWLGTEGSSRKAEGFVQWLSPNYVPDLNPRRWNQEVVELASLDPTVSHPTLLFYTYGEQSQYITSELLKIPDPQKKDAFLLNFFKPYYSRLPHYSDSNPDCKPSGFMATDWLHDELSGFGSYSNFQVGLEEGDADIRTMREGLPDHGLWLAGEHTAPFVGLGTATGAYWSGEAVGKRIAEAYYGRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0W4</accession>
    <name>S0E0W4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable DAP1 Damage response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430584.1">
        <property type="nucleotide sequence ID" value="XM_023577526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0W4"/>
    <dbReference type="STRING" id="1279085.S0E0W4"/>
    <dbReference type="GeneID" id="35400768"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07291"/>
    <dbReference type="HOGENOM" id="CLU_042860_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="121" mass="13243" checksum="0FEBED98A68ABF6B" modified="2013-09-18" version="1">MAGKFEPKVPVNLDPPKDDIISREELAKANGADGNKCYVAIKGKVYDVTGNKAYLPGASYNVFAGKDASRALGKTSTKPEDARPEWQDLDEKEKGVLNDWITFFSKRYNVVGVVEGATNMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1D9</accession>
    <name>S0E1D9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to cell division control protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430641.1">
        <property type="nucleotide sequence ID" value="XM_023577591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1D9"/>
    <dbReference type="STRING" id="1279085.S0E1D9"/>
    <dbReference type="GeneID" id="35400826"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07349"/>
    <dbReference type="HOGENOM" id="CLU_052857_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="296" mass="32833" checksum="BEFA8327FB8C5FA5" modified="2013-09-18" version="1">MESLLSLAFDNLSSYDGPKVRKGLRQVEGLLAQICLSKANSRNDRAHRNRDADDDGSEGSTPSQKDLSQLSRDPAFREFFKLQEGFEWNVAMRLISTLDRLMAKGGDGGNDLLILSALDLIQGVLLLHPPSKSLFSREQNMNLLLDLLEPFNCPAIQSATLLTLVTALIETPINTRTFESLDGLLTVTSLFKSRSTAREVKLKLVEFLYFYLMPEIPSIPRADQRDSVPAMLQRSPSKLAGAFNADSRRKRSGSDPEGDIYLTTEEKQELLSQHLSSVEDLVKDLQNCAPFGGVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1K0</accession>
    <name>S0E1K0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Probable Rad54 homolog MUS-25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_13668</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429623.1">
        <property type="nucleotide sequence ID" value="XM_023576379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1K0"/>
    <dbReference type="STRING" id="1279085.S0E1K0"/>
    <dbReference type="GeneID" id="35407122"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13668"/>
    <dbReference type="HOGENOM" id="CLU_000315_10_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="233"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="566"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT67542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="805" mass="90571" checksum="4F88779A3BC12188" modified="2013-09-18" version="1">MGAVSPIVATPLAGKDKILGKRMPTPSSIDRLHKPFKCPGVAGRSPAVDRPSRKRRKVDYGGADGEADNDKPYSNDDRLALATRDINRFPVFQAKDKGLVFRKAFSVPLKNKDSAAYNPNRAPPTLGLRQGAVFIAKPLHDPSGEFAIVLHDPTVDDKPKDVPKAIEPARTEAADGKLDAPLVHKSLAEILGIKKKVDGEHPRVPVVIDPKLAKILRPHQVEGVKFMYRCVTGLIDEKANGCIMADEMGLGKTLQCISLMWTLLKQSPDAGKPTIQKAIVVCPASLVKNWANELVKWLGPNAINPFAIDGKASKEELTRQLRQWAIASGRAVTRPVIIVSYETLRLNVEELKHTKIGLLFCDEGHRLKNSDSNTFNALNSLNVSRRVILTGTPIQNDLTEYFSLTSFANPDLLGTRLEFRKRYEIPILRGRDADASEEDRKKGDECTAALLNVVNKFLIRRTNDILSKYLPVKYEHVVFCNLAPFQFDLYNYFIKSPDIQALLRGKGSQPLKAINILKKLCNHPDLLNMADDLPGSEQCFPDDYVPKESRGRDREIKSWYSGKMAVLDRMLARIRQDTNDKIVLISNYTSTLDLFERMCRSRQYGCLRLDGTMNVNKRQKLVDRFNDPEGDEFVFLLSSKAGGCGINLIGANRLVLFDPDWNPAADQQALARVWRDGQKKDCFVYRFIATGTIEEKIFQRQSHKQSLSSCVVDSAEDVERHFSLDSLRELFQYRPDTKSDTHETFKCKRCKPDGKQYIKAPAMLYGDTSTWNHFVNEGLKPIQDLLLRQEYGESEVSAVFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1V3</accession>
    <name>S0E1V3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428719.1">
        <property type="nucleotide sequence ID" value="XM_023575554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1V3"/>
    <dbReference type="STRING" id="1279085.S0E1V3"/>
    <dbReference type="GeneID" id="35397161"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03680"/>
    <dbReference type="HOGENOM" id="CLU_049944_5_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="154" mass="16448" checksum="E197995E1E6AFC95" modified="2013-09-18" version="1">MGKQLDSFCDLVSFCVAPSVMVYSAGFDTVADQLALAFFVCAGVARLARFNIAAHLVPKSDQGKAMYHEGLPTAYAALLISTAVAVAEWTGCLASLTSGSHYPVIVVVLIFSAAMVSKRLHLYIDGAYSIPAVSMLVFAGCWSHSPMPIRTLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2E9</accession>
    <name>S0E2E9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-CoA thiolesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430955.1">
        <property type="nucleotide sequence ID" value="XM_023577979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2E9"/>
    <dbReference type="STRING" id="1279085.S0E2E9"/>
    <dbReference type="GeneID" id="35401175"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07698"/>
    <dbReference type="HOGENOM" id="CLU_051867_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF64">
        <property type="entry name" value="ACYL-COA THIOESTERASE (AFU_ORTHOLOGUE AFUA_1G12060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
            <begin position="60"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="5">
        <location>
            <begin position="252"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT68875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40739" checksum="8762466415359A19" modified="2013-09-18" version="1">MTTPKEWKRLSFQEALELARLPDDTSSTQQAIQRFMSRQPAWTPGQELPWDAVGIPPPKITRGAYGAVVYALSALAATRVVEEEDHGNVDENRRGIHSIHAVFTNPGLSDRPFILDVSEVHSSRSFSTRLVHARQPTQSSSNLSGPFPDSDSEAPLGSPCLTSIVTFKRPVSSSDEVQGIPPQERFKDILSSRKPDQWNPCPQADVDALKAKFPNEGHGAFPILDMYKVDMSDFNKSRAIPDRRELIYYRLLKPLPNQDTNAHILCHAFEADRNSLFMLGNHLGYGHDLGIAASLSYSFYVHVNADEAVMEGDGWWMQEVSWPRFSAGRGAMESLIWSPKGKHVATGYQDGIILPMTAKPGRETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2R0</accession>
    <name>S0E2R0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_13144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429049.1">
        <property type="nucleotide sequence ID" value="XM_023575793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2R0"/>
    <dbReference type="STRING" id="1279085.S0E2R0"/>
    <dbReference type="GeneID" id="35406598"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13144"/>
    <dbReference type="HOGENOM" id="CLU_055491_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF8">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT66968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="162" mass="17992" checksum="9B6CB06D35DF8574" modified="2013-09-18" version="1">MTSFDDQGFPVVHLSSDGWSTEDEATATCFCGAVQLVLPLKKPGLLNRHVCHCIDCRKIGSAFYQSNITVDDIYLKHVRGEDNLSTFSEEKTIRANATMTNYFCKTCGTLMYRRGARFPGLTILRTGTVEQFIERRAAWSKPIDGAAQVVGMHQPSDIEGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3N1</accession>
    <name>S0E3N1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to translation initiation factor eIF-4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_07837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431461.1">
        <property type="nucleotide sequence ID" value="XM_023578135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3N1"/>
    <dbReference type="STRING" id="1279085.S0E3N1"/>
    <dbReference type="GeneID" id="35401314"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07837"/>
    <dbReference type="HOGENOM" id="CLU_030044_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="81"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT69381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="549" mass="58931" checksum="CC647AF55F28E215" modified="2013-09-18" version="1">MSSPKKKEQQKMSLGDFLADSFGGGSSWADEVEETSYVTGTQALPPSDRPRYNNNAASSWQDRGFSVREAAPQTLPDKPPYTAHLGNLSYDVTNDAVGEYLADCGVINVRLIEDRELQRPKGFGYVEFETLDGLKKALTFDGENFNGRMIKIKVADPPRGGDPGRGDSIREMGNWDRKGPLPDAPSRGGARDFGDRERRPRDPAFESRPQREFTWERHGPLAPLSPQEGSGSRDGSHPRASPDVLGDRSESYRGNRRDSPAWGEAREGGSRPRPERPERPERTATAAEKDMQWRERMRPDAAKAASPDGSAPPSPALSNAAPAQGGRPRLNLQKRTVSEAPDASSASQGSDAKASPFGAARPIDTAAREKEIEVKRLQAIQEKKEADEKAKEERKLAKEAAAKAEAEAAEAAEAAQAAEAKEAKEAAEATPEATEPKAEAAEGANGEQKVPIRNREPREGAPKSRATEASSWRSASNDQRGPRGGAGPRGGRGGRGGIREARAGPLRSNGSAAQQPASTDAEPATPTADDDGWTTVPNKKGRQGRAMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E433</accession>
    <name>S0E433_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Interferon-related developmental regulator N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430517.1">
        <property type="nucleotide sequence ID" value="XM_023577445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E433"/>
    <dbReference type="STRING" id="1279085.S0E433"/>
    <dbReference type="GeneID" id="35400695"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07218"/>
    <dbReference type="HOGENOM" id="CLU_039188_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="3">
        <location>
            <begin position="69"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="452" mass="49580" checksum="3FED926EC8C618F6" modified="2013-09-18" version="1">MMNHARVKALKGDGKTTSKKAIKSGRASAGLTPRGSPFASLLTSPAHSAAPSRAASDESEDDFEYDDTMSIASGSSLVDTNEDGTNTFDAKQFMEELQDRKHNNSDARTQLLELYIKVLRHRFAPATHEWLDDSANELAELFIRGANRGMEARERLLYLQAYLLTLSSSEDANVYEHAEGTLKQIIADDDDEECKAFGIYALCFTVLYGGGGETEALELLDYLYAIVESDGDNIDSYDNGFIVAAALRGWAFVASHVDDFSYAATMALDGFYEQLDSVDVGVQAQAAACIALIFEAARNHEEETGESWDLPVNPEKLTGRMSELAKQSSKSVSKKDRRDLRDSLMSAITSLEKGVGPGYSSAGYTPQKGDKRPTSKPNEDGVIEFGYRHKLRLGNYVAVIDSWSLSSRIDMMRLLFGGHLQKHIFDNPVVAECLSDANFSDQGPVAKKSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4S8</accession>
    <name>S0E4S8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">FFUJ_05569</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431745.1">
        <property type="nucleotide sequence ID" value="XM_023578794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4S8"/>
    <dbReference type="STRING" id="1279085.S0E4S8"/>
    <dbReference type="GeneID" id="35399048"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05569"/>
    <dbReference type="HOGENOM" id="CLU_011476_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000151">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase btgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="156"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCT69665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="688" mass="74922" checksum="68618A0540629662" modified="2013-09-18" version="1">MQNYHGDPYESEPLDSHNRYDSSARRPIPPPHSYSPSAAHYDAPPRSNHPRAHPDSSYSRVQGGYDDYSSHGRPVSPSPYAGSAGYDSPRRPSPQQNDHGYYGNQGYNNYGGGGGGHMGYDHPNSHTTPGADNFGMSASGGMTGIAVNVADRNPRYSGIGAMEHSNLPPPPSRTQQNPHGGNGGYGHGYDSPRGPPSAATSHFNGSDPYIDNPYPGYTNSRHGSDNLGVVNPNDIIDDGDDGLVYGKSQRNSMLSLSNSDRAKRGASATAAAVGGGAAAGGLLGGRGGSYEMNAREKPYGYGSDDKDTGRSKRCKWLIIVVVFLVIVGAIVGGVVGSMVNNGKHDDSSASSGESAKDDTKKNGDLGKNSAEIKELLNNPDLHRVFPGMDYTPLNSQYPDCMHNPPSQNNITRDVAILGQLTNKIRLYGTDCNQTQMLIHALDRLELKDTKIWMGVWLDKNETTNDRQMAQMWDILDEYGEDPFEGIIIANEILYRKEMNITTLADILDETRTKLDKKGIKLPVATSDLGDDWTSELATDSDYIMANIHPFFAGVTASEAAAWTSNFWKTNNGDFWKTDTKKNIISETGWPTGGGTNCGSATTCTEGSVAGVDELNTFMDDWVCQSLKNGTNYFWFEAFDEPWKERYNTKGKAWEDKWGLLTSDRELKKGVKIPDCDGKTIQDYSMFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4U8</accession>
    <name>S0E4U8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial outer membrane protein porin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_07531</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430802.1">
        <property type="nucleotide sequence ID" value="XM_023577794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4U8"/>
    <dbReference type="SMR" id="S0E4U8"/>
    <dbReference type="STRING" id="1279085.S0E4U8"/>
    <dbReference type="GeneID" id="35401008"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07531"/>
    <dbReference type="HOGENOM" id="CLU_044399_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000004">
        <property type="entry name" value="Por1 mitochondrial outer membrane porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT68722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="283" mass="29816" checksum="9B9B7F821557B20E" modified="2013-09-18" version="1">MSVPAFSDIAKPANDLLNKDFYHLSATTFEFKDTAPNGVAFKVTGKSSHEKATSAAIEGKYTDKPTGLTLTQTWNTANALDTKIEVADSLAKGLKLEGLFNFLPATAAKGAKFNLHFKQPGFHGRAFFDLLKGPVANVDAVVGHEGFLAGASAGYDANKAALTAYSAAVGYAAPQYSAAITASDNLSVFAASYYHKVNSQVEAGAKATWNSKTGNAVGLEVASKYRIDPVSFTKVKINDRGIAALAYNVLLREGVTLGLGGSFDTQKLDQATHKLGASFTFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5Q0</accession>
    <name>S0E5Q0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_06186</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432313.1">
        <property type="nucleotide sequence ID" value="XM_023579483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5Q0"/>
    <dbReference type="STRING" id="1279085.S0E5Q0"/>
    <dbReference type="GeneID" id="35399663"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06186"/>
    <dbReference type="HOGENOM" id="CLU_098726_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="14">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT70234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="156" mass="17077" checksum="C529BE1F13E80983" modified="2013-09-18" version="1">MSSAEEVQARLKKLGLSARTGTGKGTPRRKVKRAPARSGADDKKLQLALKKLNTQPIQAIEEVNMFKQDGNVIHFAAPKVHAAVPSNTFAIYGNGEDKELTELVPGILNQLGPDSLASLRKLAESYQNLQKEKGEDDDEIPDLVEGENFENEPKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E674</accession>
    <name>S0E674_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431307.1">
        <property type="nucleotide sequence ID" value="XM_023578512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E674"/>
    <dbReference type="GeneID" id="35407726"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14274"/>
    <dbReference type="HOGENOM" id="CLU_042073_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001907">
        <property type="term" value="P:symbiont-mediated killing of host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.10">
        <property type="entry name" value="Pesticidal crystal protein, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038979">
        <property type="entry name" value="Pest_crys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005639">
        <property type="entry name" value="Pest_crys_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036716">
        <property type="entry name" value="Pest_crys_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37003">
        <property type="entry name" value="ENDOTOXIN_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37003:SF2">
        <property type="entry name" value="PESTICIDAL CRYSTAL PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03945">
        <property type="entry name" value="Endotoxin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56849">
        <property type="entry name" value="delta-Endotoxin (insectocide), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pesticidal crystal protein" evidence="2">
        <location>
            <begin position="44"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="372"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="502" mass="55727" checksum="C32132B20CCE3369" modified="2013-09-18" version="1">MGIKISEKFLNDLTTKLIKAADSGQKLGVTDPEEVGQYVCSVLALGCELIPVIGSSLSALTTLFGSLLFHPNATEKIWEKLRERVEALAKTKITETQLSILRKKIRGLQDNMENYTRVWEDYKDSSGDEQMRARDTLKMTHIAFLSVVRAAIPEFRVESFAVPSLPLFALAANIHLMLLSDGIRHGIAWGYSEKNINTMSAEFKKKTSPQGVVGYAATMASEQNHLLKGAIATAIDLEMPSTIVATWEDAYSDLAVPASGYTGNGEGYDDLDYATYAYKVYYKGRGQVKPYHAELNDADNRGGTAAATLRAYADYDSGMVMNVLNYAEYWPYLAGDKMPESVLRKLDREIYFGPFGRHTTNAAWSEYSEAPVTDRGPPITSAYVRGWDDIDGLQMRYGNSWGHAYGSTTGGAPKQLDLAEDEYFYWVSVYYGQKLGKVRFWNNKDKALECGSGKHGSYYGCAAPPGYRLTSVYITKWESFTPPGCEGIILGFRPSIIEFTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6A9</accession>
    <name>S0E6A9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_06402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432508.1">
        <property type="nucleotide sequence ID" value="XM_023579723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6A9"/>
    <dbReference type="STRING" id="1279085.S0E6A9"/>
    <dbReference type="GeneID" id="35399879"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06402"/>
    <dbReference type="HOGENOM" id="CLU_005533_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF17">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="243"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT70429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="345" mass="38844" checksum="629064A197101FAB" modified="2013-09-18" version="1">MAEPVDLSFATRPGNIDAPGDLLQELSIIQRDLVHGDENIRQTMLVKARTLVHSLQTPREIMVQHTWAGDLEEVGQDEYRLSSFTKSLTLYVIGDGYLALFGGIGRSPIEFYKFVRQTQWKNPTDASHTAMHVSYDTKVPNCFEYLRPIGSGPQTNNHMGGYRQGRLPWMHPSLYAVEKTLFPGSDQAPDAPLLVDVAGGLGHDIHGFKKFYPEHPGVSFTFTIKTTTTDRPPKKLILQDLPVVINDILHNWPDDVCRKILARLAEAMKPGYSKLLIFECVIPRTGAYWEATAGDILMMTQLSALERTEDNWYQLIEQSGLNLKIVKFWKCGVASVENLIECELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6Y6</accession>
    <name>S0E6Y6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_06420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432524.1">
        <property type="nucleotide sequence ID" value="XM_023579743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6Y6"/>
    <dbReference type="STRING" id="1279085.S0E6Y6"/>
    <dbReference type="GeneID" id="35399897"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06420"/>
    <dbReference type="HOGENOM" id="CLU_023194_5_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="187"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT70445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="419" mass="47510" checksum="FA335A0FA9BF35BB" modified="2013-09-18" version="1">MSSVSGFLRRNWQAYSPPEPPKNANAIKFGILGAANIAATALITPAKSHPDIKIYAVAARQKEKAEAYAKKHNIPHVFDSYQAILDDPSVDAVYIPLIVTLHCEWAIKAIAKGKHVLLEKPATVNAAEAEMLFRSPLLRRPDAPVLLEAMHFRFQPSWQYFLSLVDRQNIQTVDSVALLPSYIIPKGNAQLEYNLGGGTMLHLGTYPMYALRQIMGREPEECMACRIRSVPPPGDLCDEFAETRFRFPNGRIGNAIINARGSITTFPTFNISVCHKEIKLDDMTLPKEQTKWKLRKLSVSNFLISSFWHRIDIVDEYTIRDDRNDTDLKKWTVKQSKKVYTFKDAGIDQPSEPFWSSYRHLLEQFVTRVRGKQGSGLWVGHEDSIAQARMIDMAYEKSGLPLRPTREFRLEDYSASLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E784</accession>
    <name>S0E784_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432790.1">
        <property type="nucleotide sequence ID" value="XM_023578949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E784"/>
    <dbReference type="GeneID" id="35408289"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14923"/>
    <dbReference type="HOGENOM" id="CLU_164879_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="107" mass="12977" checksum="7F88DB054678C512" modified="2013-09-18" version="1">MTTRNLHKTWRDVMFEQYQAGLEADSPFPVRYLIFVYQWKKDIFIIIPNKIDVMTFRRAILDFVRSRNREEDPTFSNEHISVWPRKTFRERQEEESAKETNESGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8Q1</accession>
    <name>S0E8Q1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_06104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432236.1">
        <property type="nucleotide sequence ID" value="XM_023579391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8Q1"/>
    <dbReference type="STRING" id="1279085.S0E8Q1"/>
    <dbReference type="GeneID" id="35399581"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06104"/>
    <dbReference type="HOGENOM" id="CLU_019472_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="85"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="85"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT70157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="529" mass="57980" checksum="A64C76E3F2792A8B" modified="2013-09-18" version="1">MSTYNSMSGLPTGASSSQAMAMNFGSAHSQSMNMDVFDQDMTFDESLLDGAALQTLPFGTSYDLDAFSSTFEDPFSYSTRQQFDPPPNQDALHEESSPQEPDNKLLGFSAPVSNATIVNENNQFVDAGMTAELYGMFFVAEDVFGGESTGRPMELTCYRRNLWQCSGQITLPRGIRNIVSEQGQHIPIFELVATIAAIESIEGKATEIISIPWKNANPQGGDDSKGVSAPPTITLDITTGQEIDAHRVSLPISWKRLQFKHATANNGRRKGLQQHYVVQITLLGKTQAGELIKISEIKSGPVIVRGRSPRNFDSRKDVPLTGDKRFERRSTSTSNVDHPTLKLERENSTNFTQRFPPAGNLQPNDWATPGSMTHPLPSPQPVASPHPAKRVALSPTMTRPPIPAWSSDPNNSAKAANSHSNKNSLPRQNASLPINLSLSEDERSPNRSSAELHSPNSGKGHTTAGANRENSPADEGADPLYEYFPLTVDDWMPPVDAVYRPHVVHHTIMPPEMKAQQLKSKAKRYFASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8Q5</accession>
    <name>S0E8Q5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_08690</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="4"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433333.1">
        <property type="nucleotide sequence ID" value="XM_023580580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8Q5"/>
    <dbReference type="STRING" id="1279085.S0E8Q5"/>
    <dbReference type="GeneID" id="35402166"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08690"/>
    <dbReference type="HOGENOM" id="CLU_008492_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1740.100:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 21" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="20">
        <location>
            <begin position="110"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="166"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="17">
        <location>
            <begin position="553"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="493"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="725"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="867"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT71254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="919" mass="102090" checksum="15A187DA8C4DF3E8" modified="2013-09-18" version="1">MEEIKLEEGTNGAQVKQEERTPMSVTNGGQGESRSPSASHDGVKSRSGSADTPSSNRPSKLSRKASQKLAASREPVLFDHLPDMTAESCNFFQLIPDCLYGSKHLGSTDNDALDCECREEWHNGENIACGEDSDCINRATKMECSAEAGNCAGGCQNQRFQRKQYANVSVIKTEKKGFGLRADSDLQANDFVFEYIGEVINEPTFRRRMIQYDEEGIKHFYFMSLNKSEFVDATKKGNYGRFCNHSCNPNCYVDKWVVGDKLRMGIFASRKIQSGEELVFNYNVDRYGADPQPCYCGEANCVGFIGGKTQTERATKLPAATVEALGIDGGDGWDTSVAKKPRKKKPDEDDEEYVNSIPSRSLNEEDARKVMAALMQCKEKWIAVKLLDRILRCDEERVIHCVMRMHAYQILKTTLNTFIEDHNVVLQVLDILDKFPRLTRNKIQDSKIEAAIEGLTRSEHEDVASKSKYLLDEWSKLEVAYRIRRRKFDPNAPAANSFEERRGAGRDEEAAQSSKTASPQTIDAPKGPRNSMPQRNVAFFQNGGRPRRPPFTGGLPQGWFTAKDAAGNTYFYNKQGTTTWQRPTQPVAEPAVKAPSKAMKEQLAIQSIINQVTERGTPKQASVSTPKTADTPPKEIKEEKWRSLPVEKQMKIYENTVFPHIKHVLDKFHHKLPKEELKRFGKEIAKKLVSSDYKNNRVGDPNAPLSEKQARKMKQYVKDFLDRAVKKFGDQQKPRAGENTDTQVKGDQGPSAAGSSTGSVAGGLEGTSLVNVNGTPADGLDAATASDNEGSGSLGSPERKRKRESEVEGPLSISPSEGPNMKRLREDELDAPSPPPPPPPPPQSAMDGVVNAEQQALREQEEALVRENEEAQRLEDEANHTKDLEDATRGVGKDLLDTSHELSRLNHEARGIGSQKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8X1</accession>
    <name>S0E8X1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to protoplast regeneration and killer toxin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432311.1">
        <property type="nucleotide sequence ID" value="XM_023579481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8X1"/>
    <dbReference type="STRING" id="1279085.S0E8X1"/>
    <dbReference type="GeneID" id="35399661"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06184"/>
    <dbReference type="HOGENOM" id="CLU_000288_126_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="907"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="920"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="941" mass="103172" checksum="FE9924D2CF56039B" modified="2013-09-18" version="1">MAYEGGYGGQQRPYGGQAPPRHAPRQQVNAPPQQYGASQQYDEYHQDYGYGSGQDFGGQRQDQNYGRGPPPQDQYGRGGSVIPGPRGGPIPRPQTADPHRGQQRPPRGGPMPGAARGIPNGHPGQGGIRPGPYASNSDPAARRHPMNTPPMSPRDGHFGHKHVSQERGRRPDIPYEQQMVDQMSNMDMNQRPMVPTNGRTSSDAQRSQGEYGRPPVNAVRGPPPRGYPQGGPPRQNPGYGAPDGYGNYNDGYNGAREPPAGGFGPPARSRTMPVDDMRQRGNMPPPKRMDAMQYSTPAGRGIPQRPSTAGGHRAPPQRSYTAGPQAGPGGHYSGEYDDQNTYHTPSTASYDEVNDAYFDNQHNSHPEYGPESQHNRVSLPDFDAAPAPGQRSSFEQSMRPSNEQPQRGAHQTAVLNHAKSQPVLRQPQTAVFEMAGDVPDVPAVPPVPPMSNYQAAYDQDYNQIPARGPSAPAAMNGAHTSGPMNPDGLPSHPAPIRPGLMQDSMVHLGNKPAPIRNYGVSTPAPQTQPQPQPQAQPRQPQYQQQQRSPPRNNTQRQPARDEGPVTTQELEHLRMLIKNNSSDQDSALRLAKKLVEAADVLAPKMPDPKQRTRARERYLIDCHKILKKLANAQNPDAMFLLADCLGRGLFGDSDHKEAFTQYQSAAKLGHPAAAYRTAVCCEIGHEEGGGTRKDPMKAIQWYKRAATLGDPPAMYKVGMILLKGLLGQPKNPREAVGWLKRAAERADGENPHALHELGLLYESAQPNDAIIRDEAYAYSLFLQAADLGYKFSQYRLGCAFEYGLLGCPIDPRQSIQWYSKAATQEEHQAELALSGWYLTGSEGVLGQSDTEAYLWARKAAIAGLAKAEYAMGYFTEVGIGVPPNLEDAKRWYWRAAAQDFPKARERLEDLKRGAGKNGARQRERISRSKMERQQEGDCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9D2</accession>
    <name>S0E9D2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to component of actin cortical patches LAS17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_07989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431133.1">
        <property type="nucleotide sequence ID" value="XM_023578303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9D2"/>
    <dbReference type="STRING" id="1279085.S0E9D2"/>
    <dbReference type="GeneID" id="35401466"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07989"/>
    <dbReference type="HOGENOM" id="CLU_017548_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="452"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT69053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="518" mass="56752" checksum="2552248D78EC2DF3" modified="2013-09-18" version="1">MPVQQHVLNWLYSVLTSEYHDVNRAYNDVAQALDRFPSLSPRTDVHTFSNGANALLLHLSGTLPVNFRGTTYRFPISIWVPHAYPREPPMIYVVPTETMMIRPGQHIDPQGLVYHPYLVGWAEFWDKSNLRDFLNILTDIFAKEPPVVARQPQARPPPAQANPTPPPVPPLPPGMGSTSRPATQDPHPSEQPRPPPPPPKGPQTTSPAQTQSQNGPPLPPIPGRSPAQSNRMSRYDSAPPLPPQVGSPNAQDPRLPRPQEQYATRHIPPAGPPMAAQPGYMNDTQSFASPSQQQWQMPPQHQQYQQPPQPPAWTAQAAPPPQSPAKPPPPPDLLDEPLELSLPNSTVAAPPIPPNPEKDALLRQLAQTLYSIRMRSRQQNDSSMAGLQAQRTAMLSAIPAFQAEGGQLTQLSNVLTSNSNILHDALHKADAVIEGSKSHPVPDVDELLVAPTVVANQLYTLVAEERAIGDAIFMLGRAVERGRITPAVFAKTTRTLAREWYLKKALVRKIGQGMGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9F8</accession>
    <name>S0E9F8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433389.1">
        <property type="nucleotide sequence ID" value="XM_023580646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9F8"/>
    <dbReference type="STRING" id="1279085.S0E9F8"/>
    <dbReference type="GeneID" id="35402106"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08630"/>
    <dbReference type="HOGENOM" id="CLU_075862_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="24339" checksum="43586858FEE25734" modified="2013-09-18" version="1">MGENPPEEAPFPLTEVDRWVLSQTDEEFHKHDWEELKEIIRTNNLSVLKRKPSDLRRYMAWTAETKAEYGSMTNYLLVNRLPQEWGNPPFTPRSTVPFEDPSDYRILINDWPYGLEPDIRHIVVWLRATVPTDSETGDMTPESRALVQSFIKKTFIDALGPNGESNVLWFKNWVALQSVRALEHIHVLVRNVDDDTLERWTGEGPKQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9X9</accession>
    <name>S0E9X9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_08219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433763.1">
        <property type="nucleotide sequence ID" value="XM_023581104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9X9"/>
    <dbReference type="STRING" id="1279085.S0E9X9"/>
    <dbReference type="GeneID" id="35401695"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08219"/>
    <dbReference type="HOGENOM" id="CLU_022329_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT71684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="628" mass="69614" checksum="318DA449A567F1D7" modified="2013-09-18" version="1">MLPELGEVAGEDTDTLCTNGNQQPVPDRGRHCLRSGMEKNLDARDKTSGVLNTTSVQGVGVDGLMGNVSQSDEAEMLGSRGLTVETSGYPEVDDPVDPARVLNRQDLIKQRIIFLGAILLLNIILAITAILGKESKTLWPPDPITQRWILSLIPAYSESEEQIVKTIFSLRDNGTEPHRQVMVVILDGQPRDIRGNMTRVITQLERAYISFKWKKGTLRIIAGYMEDVPVIVLEKLKNGGKKDSLILCHDLFNCIRPNAPIYTKLLREEIWTHILPSLLPETDKFDGFDMVFCTDADSTIHKGALAKLANALCRNKNAIAACGLVLVELEPGYEWSVWNLYQQFQYTFGQYVRRRAEHYIGKVTCLPGCITMISVREEMGGAIQKYAEPITGALVLSHQVQYLGTDRRLTYSMLSQGKHLHTLFVPDAVSETVAPQSIQHYLSQRRRWGSNAYFNNYFYLGGEKMILITRIVATIEVVRLSLVYYRVLNTIMFLKRVSHGVPVMKLIPMLVIGQLPSCWFFCSVLIERELRRRAHKLVLGFCINKCISPIMSIIIFTKVAINLGSQAWGMSGVTASSAPAAATADAGGLTDNNILSTSAIEAIESQVDAAIIASVSSIASFSGVSVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAM7</accession>
    <name>S0EAM7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to negative acting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432891.1">
        <property type="nucleotide sequence ID" value="XM_023579810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAM7"/>
    <dbReference type="STRING" id="1279085.S0EAM7"/>
    <dbReference type="GeneID" id="35399957"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06480"/>
    <dbReference type="HOGENOM" id="CLU_013866_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="525" mass="58501" checksum="5C654208BC109F0A" modified="2013-09-18" version="1">MVYCAEPARSVESRGERAGSKCDGYRGEEYVIFRDQTAETLGKVSVFSTAKLPNGNQDVLVRPKLSQQAKVHHSQDTSSHYPWFRLEVTPEDQVLPFFFHHYVLPESGRSPTHPDCHGIIYKRATEPGYLANLINAVGLAGLAYLRNAPTLINLARQSFSHALRDICAALMDPSEASSDQMLVAVMLLALYEVSLLSLPGQLRPINNLKQTVAFNSDGGLSPWSRHVDGAMALLQLRGAGQLRNRIGRSIFHNLRSEILINCLQRRLPVPKVLIDFMAEARSNETEQEAPAARLAGIVVSVCNSSSAAEEDITDEGTLSSHVSRLLSIDADLKDWAQTLPIEYGYKTRTKPSDLDEVEVFIGRYDIYSSVEIANMWNLQRCARIIVRQALVETLSKYFPIPFSLSFSASYRDLLQTSTIVIKETSSDICCSISYILHEFDEAGKSSDLRAAHAVHLLWPLHIAGTTHNATEALRDRIISTMEDIKDAAGIQEAKRIALDLQQRGSELRCQHNTTNQTDHDIWNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAS9</accession>
    <name>S0EAS9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable ubiquitin--protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434094.1">
        <property type="nucleotide sequence ID" value="XM_023581388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAS9"/>
    <dbReference type="STRING" id="1279085.S0EAS9"/>
    <dbReference type="GeneID" id="35407443"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13989"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="172" mass="18919" checksum="9C17903BF8239F0C" modified="2013-09-18" version="1">MDTAAMSSRLRRLAKELQDCQDTGVNLQPCNPDDLAHLEASLSIPPDTPFFGGTYTINVLVPDDYPFAKPSMRFNQKIYNPNVNPDTGEIAPGALGSWDPTNTIKATLATIAKLLQHPDSRYPLNSEADLQSRETPSLFKERAQEWAVKYAGAPTTETDSASYGGYNRNLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAT5</accession>
    <name>S0EAT5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to Tripeptidyl-peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_13984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434099.1">
        <property type="nucleotide sequence ID" value="XM_023581393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAT5"/>
    <dbReference type="STRING" id="1279085.S0EAT5"/>
    <dbReference type="MEROPS" id="S53.007"/>
    <dbReference type="GeneID" id="35407438"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13984"/>
    <dbReference type="HOGENOM" id="CLU_013783_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495728" evidence="9">
        <location>
            <begin position="19"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="10">
        <location>
            <begin position="198"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT72021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="598" mass="64703" checksum="3F1C35B6120295C1" modified="2013-09-18" version="1">MHCYATVVALLGAQIASALPQSQWKALSGDEVVRAAVAFHQPKLAEAEALLMDISDPNSEKFGHYLELREVQDLFKPRDSSQKNVLQWLEDAGIDLSSVHLKKAAAVLEFSAPVKKLGKMLGAGVHVMHNDATGELRLEPADHAVPSAIEDDVEFITLAQSQKTGKTKRSRAVKPVLDTLPPPYKLPVADDLRNCSESWTPACIRKLYGIPLGTKAAKNNSMGLFGYGDPYQPADLNQFWAKHAPFIPKGTKPKVNSINGAEAEGVPIEGEELLDIEMSYPIVYPQTVTMFQTPYNNKGGLANDFLDAVDASYCKYDGGDDPDLDPTFPVFGGFQGPAMCGKYKVTNVVSISFAIDEQTLPRRYIQRQCHEWMKLALSGVSVLVASGDRGVQGATQCTVNPYDAKKEAFNSLFPGSCPYVTAVGATQVNFTGSRTNEVAVFDPKHNFYSGGGFSNMNAQPAYQRKAVADYLAANNPHYPKGTYNISGRAIPDVALLGANVTFLQDGKTTISGGTSAATPMFAAMINRINDERLLAGKKPIGFLNQILYQHPEVFTDITQGSNPGCDTAGFKAAKGWDPVSGMGSPKYPKLRDLLVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB65</accession>
    <name>S0EB65_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433978.1">
        <property type="nucleotide sequence ID" value="XM_023580979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB65"/>
    <dbReference type="GeneID" id="35401808"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08332"/>
    <dbReference type="HOGENOM" id="CLU_096562_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="248" mass="27527" checksum="C754AE12B8F95CAB" modified="2013-09-18" version="1">MAPEAQPFPVATNRDAIANTLSLLLASRTSIGKSMPLTRDLPRKQRTLPDNNDEDLARGARPNEGLGYVPEKKDVQKFANSKEERMLRGRLNKDAKGNLKKKAEESESEDEAGRSALGKRKRPRKEKEKEVEPEPEAGDQTSPVTPEDKETNENGGEFEVDADADMKDAVTQDGPILGGGQTEKKRKKKSKNKKNKKQKTAPGVTGGEGRGITFIYISFISRYPQYTQRVDIISQKREMPGSNLTCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECR6</accession>
    <name>S0ECR6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434819.1">
        <property type="nucleotide sequence ID" value="XM_023582263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECR6"/>
    <dbReference type="STRING" id="1279085.S0ECR6"/>
    <dbReference type="GeneID" id="35406089"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12633"/>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF102">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="346" mass="38539" checksum="F92D86C31C18F04E" modified="2013-09-18" version="1">MALQESQHEGNTPPPEPVIQIQDAIAAGDDDDADSSIGEEVEPSVVSISSSILAYRQENGRSYHALSSGKYVLPNDEEENERLDLQHELYVRTLDGDLALCPKAKGANRVLDMGTGTGSWAIDYADANPQAEVIGVDLSPIQPALVPPNVSFEIDDLEKEWTWTQKFDFIFARMMLGCFTDFPQIIKVAFDNLEPGGYLELQDMSLPARSDDGTLHSESYLSKWCRSCFEAGQNLGRPVFPTTEYKNYLAAAGFVDIVEVQQKWPSNPWPRERKFKELGAWACANIAGGLDGLSLAYFTRGLGWSTEETRVFCAHVRKDLQNPRIHAYWPIYFVYGRKPLTPAGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDV0</accession>
    <name>S0EDV0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435169.1">
        <property type="nucleotide sequence ID" value="XM_023582148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDV0"/>
    <dbReference type="STRING" id="1279085.S0EDV0"/>
    <dbReference type="GeneID" id="35405987"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12531"/>
    <dbReference type="HOGENOM" id="CLU_019942_1_2_1"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT73091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="567" mass="60922" checksum="ADF711CB5FA2A7B2" modified="2013-09-18" version="1">MADKTKIRYTYRGYDAWQASEAQLKKLIQDDTGVEFWIETRSIPPMGISPPVTKDCVEKLKGLDGVEAKVLLTRHFSISVGRYGINKVVSSAAEALKDMKPNTTILCGGFGLCGVPDTLINEVLNKSDVTGLTAVSNNAGTDEFGLGKLLKSRQVRKMVASYIGENKTFEKMYLTGDIELELTPQGTLAERCAAGGKGIPAFYTPAGVGTVVQNGDLPSRNKGIGSSSDAQFPDPKDVKVFDGKPYILERSISGDYAFVKAFKADKLGNCQFRLAAQNFNGPMGRNAKTTIVEAEHIVEPGEIPPESVHLPGIYVKRVIKSTAAKGIEKYTWNEQDVKTLGQGEVAAKRERIVRRAAKEFKNGMYANLGIGMPMLAASFVGPDVDVQLQSENGILGLGPYPSKERNEADPDLINAGKETVTLKPGASVFSSDEGFGMIRSGRIDITILGAMQVSATGDLANWMLPGKVKGFGGAMDLVSNPSKTKVIVTMEHTDKKGNPKILNQCSFPLTGRACVSRIITDLGVFDVDFATGLKLVEIAPGVTVDEVKAKTEAPFTVAEPLEPMTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE37</accession>
    <name>S0EE37_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435284.1">
        <property type="nucleotide sequence ID" value="XM_023567910.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EE37"/>
    <dbReference type="GeneID" id="35403580"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10113"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_15_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="4">
        <location>
            <begin position="59"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="242"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="843"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1221"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1254"/>
            <end position="1286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT73206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1424" mass="158088" checksum="5C7D839140B37FC0" modified="2013-09-18" version="1">MSHSLSQDSMLLAIFIRADYVCKSVASKRASITPTTTLDPRQQPKPQLDPEYSSRIEMAEALGIASGAAGLLSLAIEVTKLSYTYIASVRGAPKSLTSYIAELTTLTSVLLQLEDLIQAKGFNSQNIQALSKALHDCQREIEHLRAKLEKKLSYGRIKAKVAALAWPLSESELLDKVNMLHRYNSIFSSALQADNLTVAVATNKELRDIRQSTEVKEIIAWYKSDAAIEASTSHLDDYCPSTWQTFLSGSFYQSWRSGSTPVVWGYGQPGAGKTVLAQLEDTNSIHNSALVLRHVKSENFLGATIASQFFSSSRPKETVSNFLRSLIAKALRGCPVIPQEASALYEKGSQNLMMTDLTNVLGAIAKSVTTCIILDALDECPFLPKLFNILSTLQDLGVRIFAAARDLPKIRKHFEKRPRVEISATRHDLDFYVNYRLEHGEVDVESIGPELKSAIVTAIVKRAAGSFLLARLIMDHISSLLTIKEIRKALISLPANYDEAYLSTFDRIVKQTPSLRGLALKSLNFISYVKEPLRMVELQHALIAEEGMAEVDPEDLQPAKAIISSCLGLLVVSGPEKIVQLVHSTAQSFLQSRPEGMDKRPHLTIVRSCISYMSTNEMRQGCIEILLRSGASPDLPDLAGWTPTFWAAFKGQTDIIEMLWRYDKAPFRCDNKGLTPLHWAVSAGQSEIVKRLLNLKTRFKRYERSPVLSLPSLDELTVERARAMTTRANESPFKLYSDGTDIEMFSSIFSALKQSFREREDKPPERNEGYYTFDPFLYGPFGQSLKADHGRRARPDRDYQWGKPDVGFLEFVDKLLIHAVRSQDLPIIKLAFDLKLVKASGIDSLALLHEAAATGWVEGMAALIGLGADVNNAERSYKQTPLHRACQNQREEAVKLLLGIDKIDINAQARNGGASISIQDAEGNWLMHYALRTCNGTTVQMLCTTGLSIESPNKKGQLPLHWMAQWKYFDFRKDVTPDQVQAVREKRTDCMKLVFQLSSPSFLDSMCDWEDGATACRQTPLSLALKSHNWDLVAELLKHIKQPANMSSLLDPYHNSLHELCRVSERLPSVSTPGSRDRTMVYYELQPLPFDDWTRTLQLLLDAGVNINTVDWKGNTPLQLCVQRAASIPVIDTMLKLGASLYEAGKDGLDCFQLALLYSDEVGSWDIMGCLRTYANTHPDPIHYFCQGGFLIAADTPIDNEETRYLQVLRQTGAINCETRSGRTLIYEAASRGNTRLVQRLLEHDAYPHYTDDFGSSALHAAAKQQAPTTVAVLLQAGADVHHASVDECGSTLTGTPLHVCLEACNGAKIKSEAVETVRILLSYGADPNYAVVRDDHTETCLSLCLKALCRSIYYPKLDAIQSEGSDDPVLEVLKLLVDAGARVAESADDIIVGTVAKMEGHESLWETMRSQLMPHRLSSLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEA4</accession>
    <name>S0EEA4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to APN2-AP endonuclease, exonuclease III homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_05686</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432817.1">
        <property type="nucleotide sequence ID" value="XM_023578925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEA4"/>
    <dbReference type="STRING" id="1279085.S0EEA4"/>
    <dbReference type="GeneID" id="35399165"/>
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    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:phosphoric diester hydrolase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-(apurinic or apyrimidinic site) lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
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        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
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    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="8">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="8">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT70738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="601" mass="66577" checksum="2A2C3B40FB6C9C72" modified="2013-09-18" version="1">MTFRITTWNVNGIRNPFGYQPWREKRTFQAMFEILEADIVVMQETKIQRKDLQDDMVLVPGWDVFFSLPKHKKGYSGVAIYTRNSKCAPIRAEEGVTGILTAPKSTTRYRDLPEDQQIGGYPRPDQLEGIIDEATLDSEGRCVILEFPGFVLFGVYSPATRDETRDDFRTGFFQALEVRIRNLVAAGKQVILTGDLNVVRSELDSTNVSETLRKEGIDLSDWMNAPVRRIFNELIFEGSVLGERDEGREKPVLWDLCRCFHPERVGMNTCWDTKRNTRPANNGSRIDYVLCSDGIKSWFNYSNIQEGLMGSDHCPVFATLSDKVTVGDKECALLEMMNPPDMFNGDERLRDWTPKDHLPLSAKLIPEFDRRQSIRDMFTKKAAPPRESTRIDTTAEPSKNGSSSASGSLDKAEEASGSPTNASPTSRLGETTNLTKLSASQSSSKRPGTAADTTSRPFKKTKSFTGANDTKSKAAQGQRTLQGFFKPKAPTAQDGKAELVAASSTPSTTKKPAVSGKAPVSAQRLSNTPQATLTEKSSPTVPLRGKDPEPSDRVFDPIEAKESWSKLLGKRVAPRCEHDEPCISFTTKKPGVNCGTLYSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EED4</accession>
    <name>S0EED4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to OYE2-NADPH dehydrogenase (Old yellow enzyme), isoform 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCT73134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435212.1">
        <property type="nucleotide sequence ID" value="XM_023567817.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="35403663"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10197"/>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF129">
        <property type="entry name" value="FLAVIN OXIDOREDUCTASE HXNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT73134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="416" mass="45542" checksum="D96E2DCDE0EB01F2" modified="2013-09-18" version="1">MPIAVTPPAAHAALKDTVLFSPLKLGKLNLKHRIVQAPNTRMRSEFESRGVYVPGPRMVKYYSDRSSDGGLQITEATDIALNASAYPGVPGVFTDSQLQGWKKVTDAVHAKGGFIFTQLWHTGRASCSAQRGGERAVSSGDQPMPGTYLDGTDTKDDPPRALTVDEIHSITTEWAAAAKRAVEVAGFDGIEIHGANGYLLEQFLHDNINNRTDEYGGSVENRCRFLLEVLTACCDAIGADKVGLRLSPYNYFQGTKDSDPNAHWSYLCGQIASLPDKHKPVYVHMIEPRFDEVLDEQQKLAALANGSSKDGTSVEVGKQANSLNIFRNILQPSGILFLACGNFNRDNAPTKIKSQEADLVAMGRHFIANPDLAARLENGWPLNAYDRSTFYGADPPEKGYNDYPFYNPSQEVKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EED6</accession>
    <name>S0EED6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to PaaI_thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432857.1">
        <property type="nucleotide sequence ID" value="XM_023579694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EED6"/>
    <dbReference type="STRING" id="1279085.S0EED6"/>
    <dbReference type="GeneID" id="35399853"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06376"/>
    <dbReference type="HOGENOM" id="CLU_089876_12_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF57">
        <property type="entry name" value="PAAI THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT70778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="165" mass="17391" checksum="DAF08D98E57F6418" modified="2013-09-18" version="1">MSGKVKLSPTKFTQAVVRSFMADSGLEPRLLGKHFRVTSATEGRVDFELDIQKEHTNRLQTIHGGTLASLVDLGGSLAVASSGRFATGVSTDLNVTYLSPGGRPGDLLKGTATLDKIGKTLAFTQVTFTNSKGQLAARGSHTKYVTGTMGEDGPFVAPAEFSDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEK7</accession>
    <name>S0EEK7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable heat shock protein Hsp88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435163.1">
        <property type="nucleotide sequence ID" value="XM_023581867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEK7"/>
    <dbReference type="STRING" id="1279085.S0EEK7"/>
    <dbReference type="GeneID" id="35405736"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12280"/>
    <dbReference type="HOGENOM" id="CLU_005965_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="739"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="784" mass="86786" checksum="EF9C89B3127FC748" modified="2013-09-18" version="1">MSVVGIDFGTLKTVIAVARNRGVDVVTNEVSNRATPSLVGFGPKSRYLGEAAKTQEISNLKNTVSSLKRLAGRQFNDPDIQIEQQYVTAPLADCNGQVGAEINYLGKKEKFTATQLVAMYLSKIKQTAGAELKLPVQDVCLSVPPWFTDVQRRALIDAAEIAGLRVLRLINDGTAAALGWGITKLDLPAPEEAPRRVCFVDIGHSSYTVSIVEFKKGELAVKATTWDKDFGGRDFDRALVDHLAKEFKGKYKVDIMTHGRALARTIAAAEKTKKILSANQQAPVNIESLMNDIDASAMITRQEFEAMIEPLLARTHLPLEEALAQAKLTKDDIDVIEVVGGGSRVPALKERIQEFFGKPLSFTLNADEALARGSAFSCAILSPVFRVRDFSVQDIISYPIEFAWEKAPDIPDEDTSLTVFNKGNVMPSTKILTFYRKQPFDLEARYAQPELLPGKTNPWIGRFSVKNVKADGKDDFMICKLKARVNIHGVLNVETGYYVEEEEVEEEVNEDPDVSLSEPFMAPNDSPHVQDQDSASSSSASVGDDSRAYPAKRPRLDDDEEIDSSRPAFAVPEHLEESNYEPRSLTFVSQKAMETDKDAPKKTRKVKKQVRKGDLPISTGSASLDDSTKASLLEKEAAMVMEDKLVADTEEKKNELEAYIYDLRAKLDEQYSEFASEEEKQTIKAKLEATEDWLYEEGDDTTKGVYVAKIDEIRAMAGPIVQRHFEKVEAERQAALEKAEAERAAKKAEEDARKAAEAEKVNADQEMKDADAPQQETEGSADPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EES9</accession>
    <name>S0EES9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to thiamin pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435549.1">
        <property type="nucleotide sequence ID" value="XM_023568335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EES9"/>
    <dbReference type="STRING" id="1279085.S0EES9"/>
    <dbReference type="GeneID" id="35403198"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09730"/>
    <dbReference type="HOGENOM" id="CLU_048013_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="139"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="332" mass="38013" checksum="BA64B33222F9032B" modified="2013-09-18" version="1">MAKTNIDLIDEVDMFPYAETDPDAFTKMNAGLYTLVWRDSKGTYPIGYILDRVARELHQVPEEVRGEMECDDEKKTIVLFQEPTEEQRTRRAATLADYWRKNGTFPLLRRWRDELWPVYGRSGELLFSMERAAIGLLGTVRYGVHMIAYVKDETAPHGIRLWVPTRAWNKATFPGMLDNTVAGGLMTGEDPFECVIREADEEASLPDDIVRKGAKFVGNVAYIYITDEGQVGEGGFIYPECQWLYDLELPSDVIPQPKDGEAEKFDLCDVNQVKTDLAEGRFKSNCALVTLDFFIRHDILTDGNEPEIEQIKRRVHRDIPFPGPHQSNWRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEY4</accession>
    <name>S0EEY4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434505.1">
        <property type="nucleotide sequence ID" value="XM_023581886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEY4"/>
    <dbReference type="STRING" id="1279085.S0EEY4"/>
    <dbReference type="GeneID" id="35405753"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12297"/>
    <dbReference type="HOGENOM" id="CLU_073635_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="223" mass="23763" checksum="E8989A3DDC409BA1" modified="2013-09-18" version="1">MVSTAGGIVIAIIVLLVAGAVGWVIFTQLRARRLGLPPPSLASYLPWHKEDSGYGIQPAPSGIAGWFNDKIRKFKNRNNRSAAGAYEQSGGARGRRGFGPLDPDEAWDSRVGNEADQYGYYEEDVGGRGRDTGYGGGYNMNLAATPGLSGGRGFDEEEDRGRRASRSPASGPGGRNPFDDDAGSSLRGVSPRPIDTGVAKPKNRSGSAESSPTERRSVFRENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFP4</accession>
    <name>S0EFP4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433292.1">
        <property type="nucleotide sequence ID" value="XM_023580531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFP4"/>
    <dbReference type="STRING" id="1279085.S0EFP4"/>
    <dbReference type="GeneID" id="35402210"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08734"/>
    <dbReference type="HOGENOM" id="CLU_007956_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="6">
        <location>
            <begin position="65"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="5">
        <location>
            <begin position="761"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1164" mass="128146" checksum="B7151FB32AA3BDB9" modified="2013-09-18" version="1">MTDFRQWALEFVLADNEGQQTAIANKAANEIQTAAANTNPVARWVEAVQPWMPGGGNEAENETPDWTARAKALEFLSRTLDFLSSDILKPSQVKLLVSFFGAMFEVDHKAGIMPSASALSRIVAMKSFQRHMGHDIIQKVCSLKDDFPRQVSKTRLEIYELIRLLMTTPGVASDLQNTHGSSAGFMLDLIQLCRSERDPECLMVWFDILRLFMSEYTVSQDVLEEVYGVFKPYFPISLPRASQVAITPEELKLALRKCFSANHLLADKVFPFLLGKLDQGDAVTVNVKLDILKTMQACLDEYSHPQKAIAPYANQIWGSLKYEVRNGEIEDTIWGTLEVLKSLTRRLTGDSLRDYTLSVTRDCVPDLATTMYASSAGRLMVSVLSSKPSAFVLMAAPVITHIKENLRHPKAPVHTQDLLKVLHVILETRFLLVDTNMATEDREDFAAIDSFFKSLYEDVFKNPVNLGSKPDASYDDIKVATQAVPGAGVLVCQRPSKSLDLSENGASDISQRLLPEPTCSEICSSLFAILKKSGPGYTRSSGGDELINDAAQALQRAIRYFPRGFNGLVDGSLSIIRSSRQNGNVTDTVETIKTLGGLVAYLGSSELPFTPRDGFDHFIYSIRAFLSELFDSLESKSDPEIWCALVATIQSTIRYFNDACLAKNPDKEFSIEDEPLQKIGSTYPALSLLGGETVAESSPGYHSRVSQSASVTEIRSEFLLITLLIARQLYRRATKVIDTHPQTGKQALSLSDDFANVDEVSGHQYLHLISTLAGFVIHEFSETQQTSLKAESFAISLFRDESITVPKTAPEAQSSLENGSSWSWLASEAPNVLAFGILQALQPSAVSRLFDIGVAQELILSGFAADTNFSRPVTLSILTILANKFKIETVPSLITALEQRSSSLLPASTSENDASRLEQITSIYALVAGMVRRYSGKEAKTLLDVVKESPKDPKLGTELARRLEMIVAPQQPLTKECYAIIKPLWTQKVYFQLVSPMLQAATGKEAEVQDQHVKANYSTAMLLMVKHMNFPIYEADADSILRISIAVAQNSGIGPETKAALDVIKNTLAEAPEKGKGHIRSIIKICSSVFSHEPSSASADVETEGACGKLALEIVGSLPQTYDSQHLIPHAPQVQRQLTLVCGHRVREVRKTARLARAAWADLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFQ8</accession>
    <name>S0EFQ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434760.1">
        <property type="nucleotide sequence ID" value="XM_023582195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFQ8"/>
    <dbReference type="STRING" id="1279085.S0EFQ8"/>
    <dbReference type="GeneID" id="35406029"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12573"/>
    <dbReference type="HOGENOM" id="CLU_070871_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485879" evidence="1">
        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="255" mass="28984" checksum="5BA50D2732CFC090" modified="2013-09-18" version="1">MFIYRIKTFVFLMTLFCGSCKAESNGLPFPARKVAGITVVNTPIVQDAEAFALKHSTYPIYKHVMRSWLYGVLMINANETLSDSVDLEVHAVATLLHDLGWDTTEASPIISADRRFEVDGAFAARDFIQEHHHGKFWHERNVQLVWDAIALHTERSISYFKELDVQVVSKGIAMDFSGPAYGVSEEKYSAIAKAFPKSDLKDSVNDTIIWLCDTKPQTTYDTWMQPFGERYVEKYDPTGKQRIDLIFQNLTTGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFS3</accession>
    <name>S0EFS3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to SORBITOL UTILIZATION PROTEIN SOU1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434780.1">
        <property type="nucleotide sequence ID" value="XM_023582217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFS3"/>
    <dbReference type="STRING" id="1279085.S0EFS3"/>
    <dbReference type="GeneID" id="35406049"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12593"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF1">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="276" mass="29958" checksum="525F592BCE4431CF" modified="2013-09-18" version="1">MSMNESDCTVLRDGFPRPFPDTPTNVLEQFKMTGKVVVVTGGADGIGYAVAEGMAEANAHVVLWYNSNDVAIQKAQDLGTKHNVKTAAYKVDVSDAESVQKTVRQVVQDFGRIDVFVANAGMAISKPILEQTLPEFDKQMSVNVNGVVYCSKYVGEVFKQQGSGVLIITSSMSAHIVNVPVDQPIYNGTKAFVTHFGKSLAREWREFARVNIVSPGFFDTKMGAGPLALNEAYRMSVLGRQGHVKEIKGLYLYLASDASTYTTGSDIIIDGGYVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGA4</accession>
    <name>S0EGA4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_09352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435902.1">
        <property type="nucleotide sequence ID" value="XM_023568756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGA4"/>
    <dbReference type="STRING" id="1279085.S0EGA4"/>
    <dbReference type="GeneID" id="35402821"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09352"/>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="410" mass="45737" checksum="C4A72765BCE55962" modified="2013-09-18" version="1">MWQLSVSLVRVVTLAILPVCLHFIIKTLLRPSFSKLRHLPGPKSAMPCEYSVGPLSRPSIRKLFPTFVTYSRKLNGEINAAIQQSSDGVLESVSLVGQELRDFRSRTSPLSFEQCYNGILAQPLAGQIISFINPFIPLRWLPVSANLNFVKAKSALKGMMTELIEQRTSEVEKAKELGTDSGLSDDLLTRMIQASSVENQKLSKDELIDITMQVIAAGHETTASALLWTTYALSQDQKSQQRLRTETINLSANDMTAKSIDELPYLDNVIREALRLYSPTLIIPWEALEDIEIAGVRIPKGTTVQLVPAVTQLNPEIWGLDVETFNPDRWDHLSGDCLSPYAMETFSNGPRMCPGKALALLNMKVLLVGLIKDFEIESAEDKEVEFRNPSLTLKSKRPLQFKVQRIGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGZ0</accession>
    <name>S0EGZ0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435165.1">
        <property type="nucleotide sequence ID" value="XM_023581968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGZ0"/>
    <dbReference type="STRING" id="1279085.S0EGZ0"/>
    <dbReference type="GeneID" id="35405826"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12370"/>
    <dbReference type="HOGENOM" id="CLU_138679_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="116" mass="13899" checksum="F1D183A6C1EEC0CD" modified="2013-09-18" version="1">MSRSLSQKIYSDVFARWPKQALRPDHQLQDVLGKAVTERFQNYKPSMEREELLKARALQFLLQDRYNDRFKLKGRLLEPKSQPTYFADLVREIDEAPNRSWLERLGKRLTGMIRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGZ7</accession>
    <name>S0EGZ7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_09232</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436013.1">
        <property type="nucleotide sequence ID" value="XM_023568890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGZ7"/>
    <dbReference type="STRING" id="1279085.S0EGZ7"/>
    <dbReference type="GeneID" id="35402701"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09232"/>
    <dbReference type="HOGENOM" id="CLU_026244_1_2_1"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="ARHD_Rieske_2Fe_2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT73935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="403" mass="46295" checksum="ADE81BE74CD9C9DC" modified="2013-09-18" version="1">MSRWFSFGTAKEAEPQTTRALPASWYRSSAMYELERRAIFSKKWIVVSHKARFTEVGDYLRITQAGFTFFLIKDRQGEIRAHHNVCRHRAFPLVEQDTGRANILSCKYHGWSYGLDGKLAKAPKYQEVPTFDKSTYNLFPIHVHVDKLGFIWINMDASPTPTVAWNDDFAGVDTQPRLQPFDMEAYHFDHQWEMIGDYNWKTLADNYNECYHCPTGHPALNALTDLSKYWVETAGGHIQHFNVDKPDKDGMGIYSTFYYPNASITISPTFFYIMRCIPISASQTKMEYEVYRANSASDKDFNEISDCFKQILKEDKDLCNAAQKNLNAGIFINGELHPRVEKGPLFFQETTRKLVMDHHKQEEAEGHEIWPATPKSGQSGNGQGDIDFCNRLEACAGSDSLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH21</accession>
    <name>S0EH21_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433762.1">
        <property type="nucleotide sequence ID" value="XM_023581103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH21"/>
    <dbReference type="GeneID" id="35401696"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08220"/>
    <dbReference type="HOGENOM" id="CLU_108575_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496017" evidence="1">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="232" mass="25596" checksum="D3FCE5901F30E6EF" modified="2013-09-18" version="1">MYFPTLVLLLTAGLQISLVGAAKAPKNSTIKLDKCAATALTTEFSAGFKQPNPPQIKSEFTTSFVQHRWNQRTSVIVAGYLENSGSQGIIRADQAYDGSLTSSVYDYNNMTDDTMVDHTMNTFQSGASCPKVSRDYDNITFPLFSKDMLIKGGAVFTGSVTRDFSGRGVGWNIIYEGRIPLTVYVNPCNAVIGYDYFLRDERTRVVTEFFNTNITTSQRDILAGVTLPAVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH22</accession>
    <name>S0EH22_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Involucrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436132.1">
        <property type="nucleotide sequence ID" value="XM_023568224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH22"/>
    <dbReference type="STRING" id="1279085.S0EH22"/>
    <dbReference type="GeneID" id="35403297"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09830"/>
    <dbReference type="HOGENOM" id="CLU_019744_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="53231" checksum="08398A54F521F323" modified="2013-09-18" version="1">MNTSEKRRPGSGTSPAHTLRTGASSNNRNSMPAMPPRAAMASNANANPEETLDTTGGAPLKEKENAVTGSGSTKEKDRDKERKERREKREKKERERELEAALKEKDERIAYLEKEMGIMEREFHRELDKLSQNESETATFWQAKHSALNQQYLRTDTELRLLRAEVEVREGEREELREGWEVLRRELKERDDEIRGLRGQVRGLKEWVSNSTRTDGQECDEVFGDGMARLGNGLQNWVIVNFRKAKINLEALDEATLAEVNDLVPMYEELASTHKVYLLQSIVSKILVEMVFDAYFVGLSEEQTQQFRQLEKLISSYADSDEAINQWRSSTLSLLRRDGSSLKESTSSVTEAILSRITRILDALCGTSPSEARDSGLRVLVNNSIELARLVAVQKAVLRVNMPTVLPHQRVVFESETMEDLGGEDEESLTGREICCVAFPGVIKHGDEHGGHLQYRNVILKARVLCSPEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH23</accession>
    <name>S0EH23_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436033.1">
        <property type="nucleotide sequence ID" value="XM_023568914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH23"/>
    <dbReference type="GeneID" id="35402679"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09210"/>
    <dbReference type="HOGENOM" id="CLU_103863_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="128" mass="14458" checksum="E05F72DB443FF9FE" modified="2013-09-18" version="1">MSHYSVYLVESMGIPRNHHANFIKTGNKKEGTIFNVTGNAMNGSTLEIRETSQSPRSEATFESWTEIGVIVVDDLPRVKAICEANPPPGKQYDGLKKIDPEKPLRRCQEWTRETIGHLREQGVLLHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH98</accession>
    <name>S0EH98_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436474.1">
        <property type="nucleotide sequence ID" value="XM_023569229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH98"/>
    <dbReference type="GeneID" id="35403909"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10444"/>
    <dbReference type="HOGENOM" id="CLU_2171286_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="110" mass="13338" checksum="2A7E2E57D642B9C8" modified="2013-09-18" version="1">MPNRNFPRFFDIPAFLAHGKAIKETKAKLQTVKFEKEKLRKDREYVEKEIEELEKGGRNDGETDIEEDITELRTELQKLDNKKQKLNREKEKLKETKKRHQKAMERLQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHK7</accession>
    <name>S0EHK7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to L-amino-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436574.1">
        <property type="nucleotide sequence ID" value="XM_023569348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHK7"/>
    <dbReference type="STRING" id="1279085.S0EHK7"/>
    <dbReference type="GeneID" id="35404015"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10551"/>
    <dbReference type="HOGENOM" id="CLU_004498_8_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="115"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="312"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="704" mass="79063" checksum="9BAFE43DBCAB4764" modified="2013-09-18" version="1">MSLLDLNSDLSIRNQWARQHINRAIRQDWNALLEHSDDSSELGSLPFIPKTSELPPAPAPQKSSAPHDHEAQKPRAIKIGVIGAGAAGLFTGLVLDYLNSELKKGSIPLSFDYEIHEAAGSDRVGGRLFTYNFGGQRDTHDYYDVGAMRFPDNPVMKRTFELFGRLGMEKTDLKTNPNAPDGSLIPYYMSPNAPNTNPWCYNDINVWGASYQSVQTSAGTVDPFQVDTDNSIDHRLLKVGPDEVVKANVEPLRQALKEDAEKTPPGDKGWKMLMEYDTYSTRQFLGTANPKVKLPKDIPPPPYNYETIEWLETFNGGTDWYDQAHSETVLESLDFEFSPETKWFCVLGGAQQLAKKMEERITSKPTYHNPVAAIRAIGKMDVRLDIVAGKRSEYRHYDAVVATTTLGCLGRMDTRQAGLRYPVKQAIRSLGYGQSCKVAIKFSHAWWIHDLKDFNIREAGLGHSDLALRTCVYPSYNIYDAKTKTAVLLCSYTWQQDSDRLGCLMSTNKDHGQKVADEQALKELLLRDLAILHRNKQMGEKDLYTLISKSYVDHHAYSWTEDPNTAGAFAFFRPQQFSSMWNRVIQPSGDVIIAGEASSPHHAWVVGALESVVHELHSWMGTNITLVPELKHARDILEKDEPRNPFVGLPPYMDVNISNWHAVMGVVNRDKHLEKIGGSDNGNLLSTLLSHFDVDAFKKDIPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJR5</accession>
    <name>S0EJR5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434696.1">
        <property type="nucleotide sequence ID" value="XM_023582114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJR5"/>
    <dbReference type="GeneID" id="35405957"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12501"/>
    <dbReference type="HOGENOM" id="CLU_2831294_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="66" mass="7362" checksum="F993E0E06A1E484D" modified="2013-09-18" version="1">MNKAKQSADPEETPDIVPNYPLTGKAAEEDYQKQLALLEQQNKIRLEQAQGGKSSNSSTQNTDRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK33</accession>
    <name>S0EK33_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436320.1">
        <property type="nucleotide sequence ID" value="XM_023569050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK33"/>
    <dbReference type="STRING" id="1279085.S0EK33"/>
    <dbReference type="GeneID" id="35403750"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10285"/>
    <dbReference type="HOGENOM" id="CLU_023339_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="363"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="402"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="560" mass="62558" checksum="A22A1216BB194BC3" modified="2013-09-18" version="1">MASPLTHIAESPYQEFVRNQTDIHNRTGEVSRTPMTMIDRDGSVLNETEDFRLLYHIVLRNDALALKQYLTVAPWAVDSMSARPERDEAPYEGNDYFLLATQNGNLDVLQILLEHYKRNHDSTDELRFKTRGYQLLNEAARRGHNEVVQFLLDSQPLYAGIDERDCKGYTALGSAANIYSVRYTDSADWQDVCVDNNEKVMHLLLDYGASASDIVLPMNDKEETPDTVLTLAVQWASPKLINRLIKGGADIQAKVTKFPFDLGFWNERGYISDINAFCIACISANYEAVQSLLGYPGADRADMVSSRDSRGSLPIHWATRNQLPDELQYIPISILQERTRNITNVIRLLLEINATTVNIQDGDGNTPLHYATGHFGRSGKLYTNIFELLCQKGADAGICNKKGETPLHTLFRRDGSNMPVDAVSTLLAHGARVTAVDNTGNTPMHVACCNANSGDAVSVLLQHGADPTLKNSKQETPIHMVAQFRCPPRASRSKASEVVRAQDDMIDRLAKARGPELMDLKNTGGQSARQIYQDSRAKWLEGARGNKNHRHWGRRSVMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKP4</accession>
    <name>S0EKP4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437457.1">
        <property type="nucleotide sequence ID" value="XM_023570329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKP4"/>
    <dbReference type="STRING" id="1279085.S0EKP4"/>
    <dbReference type="GeneID" id="35404893"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11431"/>
    <dbReference type="HOGENOM" id="CLU_589296_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="481" mass="55245" checksum="D0FBC592E9C70882" modified="2013-09-18" version="1">MARLKDIPNEILTSIFTHLSDINHSSIFNVTLVNKHFNQLASPLRVRHWSDEGYYGYYDGDSPCPPISRLALELLRHPEYRLQVRTLSFSYFQRSGDRDAARIPMKPENLQMLAWAAEEVVPTLAESTYICARILEDNDDAIAVLVLAWATNLRSLSVTIPFFDPTPEYDEGPLVLRFAKQLALRFDSKDLKPSTPLPLAKLRELEFRHENIESIVGLKYLTPFLYLPNLKNLKTYRLGDQEYNDTQESVQNYIRDKYCMPFPKGTSSIESITIKESTLSSDGLSDLLGSCRGLRHFYLHFSFDLEENKRNWTTLAKSLVNHEESLEDLDLCVDNCDVEWVGDTVDDGAGDPKPVDFTDCYHHLTGLKALRVPMPQLSGYDLWKHSGCPKASLVRLPESIQHLRLLDINLWSNARRLSEHEISPFLDFVLNLIKETGPEGRLRNLQTLDCSKALWDDPMRKKIQEIKNLAEERRVIILLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELA3</accession>
    <name>S0ELA3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437864.1">
        <property type="nucleotide sequence ID" value="XM_023570804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELA3"/>
    <dbReference type="STRING" id="1279085.S0ELA3"/>
    <dbReference type="GeneID" id="35405319"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11858"/>
    <dbReference type="HOGENOM" id="CLU_930801_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="156"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="230"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="299" mass="33242" checksum="74768D6AEAE68FBB" modified="2013-09-18" version="1">MTTQDREITWIENLPQIYSHQLSQDIDTTASAPASPTRERKGNNSVQALDLSPLSSLSILGVNYDSPQTLAIKASSRVSSSASDRTRSTSELKRQFLELHLDERGLETKALNVDALEALLNPEAASLLRTMRRIGNCKGILPQDMRDQVLQSHSIKQDDLDDWDLAFKDSDAFAHLPGRIPSAREIELVCNWTTDCIDSKHEEAGWSDEVHFPIQPVHTSTGFRANTSTAKSYEDSCRTTPNRCVNHTDFQRLQTHPIVLSIETKAGSISDAAELQMGVWHTAQWAFLKSSLSRAQDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELG6</accession>
    <name>S0ELG6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435306.1">
        <property type="nucleotide sequence ID" value="XM_023567935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELG6"/>
    <dbReference type="GeneID" id="35403557"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10090"/>
    <dbReference type="HOGENOM" id="CLU_1261577_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="215" mass="23776" checksum="CE3CD2F546CA923C" modified="2013-09-18" version="1">MSATVQTNKPDFESTAPPQNITNAEEYRKNTDELSRELLYHVIHRLETQASKQDYTSSSSKNNSDDLEVFRFFVVTMIAISVFGASTFAVIVGEMTDPADIWATPTFTLKTVRLFLSVSWLAFAVSIALAGYSGSFLALMRQKAKGEIDEETIKKWTPAGLVVSAALHLLIVTGFLFMALSLVAYVGSFGWVIVGFSVVMYLVVFYLLIAQFRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELY8</accession>
    <name>S0ELY8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437643.1">
        <property type="nucleotide sequence ID" value="XM_023570545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELY8"/>
    <dbReference type="STRING" id="1279085.S0ELY8"/>
    <dbReference type="GeneID" id="35405086"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11625"/>
    <dbReference type="HOGENOM" id="CLU_010595_9_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30406" checksum="223CDD0C5B5B8241" modified="2013-09-18" version="1">MSSENKVDYPWEINREVERLQKQHAWVQRCLNSKIVFAPIPLDKEGLKILDVGCADGVLLRDLKKQVSPSAQLVGADIVEAFLPDSERGINFEVYDLCEFPGDRLVGVFDLTHMRYSILGAAKVGYQKAIDHLASTVAPGGWLQVHELDFDLTDRPNVGPAWRDVSNLIAAMFDGMGMESDCIRKLPGAFEAAGLENVTVHSVDLPMGKLLGDDEAAELSWQPFVITIPRLIEGAKALGVQLPDSMHDNLAARFEKEVKEEGAIFRALVTIGQKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM30</accession>
    <name>S0EM30_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438129.1">
        <property type="nucleotide sequence ID" value="XM_023571082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM30"/>
    <dbReference type="STRING" id="1279085.S0EM30"/>
    <dbReference type="GeneID" id="35405568"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12108"/>
    <dbReference type="HOGENOM" id="CLU_1408878_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT76083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="193" mass="20921" checksum="1F93DB84CFEAE75D" modified="2013-09-18" version="1">MKPTYTVQQKDTCRTIAKANKVTYAQLLSWNPTLDVTCENLSQQKDGKICISNPLGNFALPTTSKPVPTLYTTEAPISSPTGHGTNAHCGKWYKVALGDDCSVIATNNTITRKDLLFLNQELFSNCTNLLAGVYYCVQPVGYISTYPGYDGSSTRPPIQPMSATTLPNPPANTNKPALSMIPIANGTRKDCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMG6</accession>
    <name>S0EMG6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF2235 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438304.1">
        <property type="nucleotide sequence ID" value="XM_023571261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMG6"/>
    <dbReference type="STRING" id="1279085.S0EMG6"/>
    <dbReference type="GeneID" id="35407558"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14106"/>
    <dbReference type="HOGENOM" id="CLU_304609_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="3">
        <location>
            <begin position="8"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="439"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT76258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="914" mass="103222" checksum="428A386F5A0868F6" modified="2013-09-18" version="1">MSQSVPVRLIICVDGTWCEPDGAHGNRNHNITNVYRLYTSIHKGECEERSGKRFNQVKKYYRGIAAEDGISYSERLLAGILGGPCIDQIRDVYEYICHTTSDNDEVWLYGFSRGAYVVRAVAGLLHYIRAISSAGMPSFGEDFKLALKVYKKLQQQKQLGEGQIHDMFEARTRPAPIIQFVGVFDTVKAVQDERLYDISLNLSIQHLRHALALNEDRQRFAPEYIYPNFNNRTQRLEKRTFVQAWFIGAHIDIGGSAKMDGLSLYPLQWMLIESQSQGLKLKFDGDFGGRSRLESPLRLTGLEADNEAWECSTNNGLVIRMKDIRHIHQDETSQRRYEVHLHRPRGKLWIRRHREPFGENGELNGYCKFGAQGTIIHPSVYLILDQFMHVSLDSKHFPFYQVLHQWRYNTLGQKDDLRNGCFWNEPGEVVGIEDPGAIRVLVCGNCGVGKSSLINKVFGVTVAAVSHRTRGIHQINDELSWKDRPDLIVHDSGGFEAGGDDELRCVQDFLKKKSSETDLDKRLHVIWYVWWLSKQTHFHFGLLKPEQAAQDKLFKALSTYAQDVPIVAIATKKDQFLGAKWAEERRNLENRNEAVTLEKLDLYAAKEMQDELCQIDEDLKRIGHFDELVTVSKDDDKSIGSLSLATAQLFTHERVRLLYIRAQATRLDLKVDLALAETMKIYRRALISSSSIGAVPGAMATNRTAAAIDVCRTIVTSFGISTITPQTIFEICKANLWDDMGNNIRTTIAEICAVVGLGATVVTGGMPFFLLPMATNIPLVVKATARLVLMLACDVILILTRAFREAAVKSITKPERRDVENAAVAYRQHCHQVHLRVKNALSNVFKCYQTGQVETMMTQTIEKFKCTVLEGVGAPLPHNFRRDYSEKEVSDSDTSDVHSGSSSALAGVSRESKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMU3</accession>
    <name>S0EMU3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437310.1">
        <property type="nucleotide sequence ID" value="XM_023570159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMU3"/>
    <dbReference type="GeneID" id="35404741"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11279"/>
    <dbReference type="HOGENOM" id="CLU_1927680_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16412" checksum="1772F7DA96C39643" modified="2013-09-18" version="1">MSCADEIVSTASVKDWKPSAQENEWKPAGHFAGKSADEASVMDAESVPGTSSCEGDVEVFMVAVKPGLQYRKKGIAEGLLRVCELQMKKQFPPRTDQVLVMLRVVREINSQYWLKKGYQIVGERYCPPITWDVEKAFILLAMRKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENR3</accession>
    <name>S0ENR3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437845.1">
        <property type="nucleotide sequence ID" value="XM_023570783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENR3"/>
    <dbReference type="GeneID" id="35405300"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11839"/>
    <dbReference type="HOGENOM" id="CLU_004495_6_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="521" mass="57199" checksum="8EC02C5C66C23589" modified="2013-09-18" version="1">MSHGSNSIELEASGKQQPVPVSVDASARPPEDSNIYNVTRTRKVFSFSQLFAFSLTYMALWEGMCSNMYFALFNGGPQTFLFSFIIVFCGAISQAASLGEMASIQPVAGAQYHWTFYMAPQSVKRFATWIQGWSTWFGYVSLLAAIANVTIILLESMISINHPDYVAGGWHTSVLVIAMCLVHGLMNVYAFKLIPWVELVAGVLHVCLFVIFVVVLVVMGPRNPSSFWLQRNISSGWDNEYIAWNLGMLTCVWSFTGFDSAIHMSEETRKAKSAVPRAMFWSIFMNGVLGFIMVNVLISAMGSVEDMLEQPSQIQAILLNVTGSNKATTAMIAGLFIISFSVNLANIASVSRLTWAWSRDGGMPAYFAYVSPTHRVPTRSIILTVFLVCALNLLSIGNTSYVAFGAITSLSSLALYLSYAIAIASIIYVRLSGSSIKLGEWNLGRFGLAVNVFALVYTLYVIIFLPFPSTLPVTGENMNYCGPVMVAVLAIAVGLWFTHARKHWNGPNLTILEFVVANASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPA2</accession>
    <name>S0EPA2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436871.1">
        <property type="nucleotide sequence ID" value="XM_023569694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPA2"/>
    <dbReference type="GeneID" id="35404327"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10863"/>
    <dbReference type="HOGENOM" id="CLU_057358_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052370">
        <property type="entry name" value="Meta-cleavage_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139:SF65">
        <property type="entry name" value="HYDROLASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139">
        <property type="entry name" value="SI:DKEY-122A22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="277" mass="31072" checksum="BD4377F6D220C118" modified="2013-09-18" version="1">MSQASQTLKDLFFRSYNDTSSTTIVLLHGLFSCNLEWEHVIPHLSDYHLLVPDLPKHSQSRDIGPWSIEFAADSVSHLIRKHAHGGQAHVVGLSLGGFTTMELIRRHPDLVKSAFVTGSTPFRPWQVWAAERPNLLHYGLKLVLNSGFYTLSVWMKGLRDHTQLKNEIVANNDWNLVNDAYAGLAKWQHEDVKAVAEKDKRILAAAGDQGDDFDGAKEMALTFRNEGRGDGRKSTAVLIKGAIHAWNLQFPELFAEGIIAWVEEKPLPQDFVNLIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPC4</accession>
    <name>S0EPC4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436951.1">
        <property type="nucleotide sequence ID" value="XM_023569787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPC4"/>
    <dbReference type="STRING" id="1279085.S0EPC4"/>
    <dbReference type="GeneID" id="35404409"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10945"/>
    <dbReference type="HOGENOM" id="CLU_065200_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT74873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="210" mass="23444" checksum="E9FF8822E6F348B5" modified="2013-09-18" version="1">MSCFKPPNEVPRDGWKQDSLGTYASPTAARIRRVLAVSVGVFHALIAIGYGDSSLVCPHPENINSELFSWNSYTLACLSMIIVIGGPLRLTAFAQLGKNFTFQLGPPDTLMTDGIYRYIQHPGYTGQIVVLVVNLALFLRWDGAFGCWIPHGFRSAISGWGLIFCLVLVFGILRRLMMRVKDEEKMLKETFGEKWVAWSRVTARFIPGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ49</accession>
    <name>S0EQ49_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438326.1">
        <property type="nucleotide sequence ID" value="XM_023571238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ49"/>
    <dbReference type="STRING" id="1279085.S0EQ49"/>
    <dbReference type="GeneID" id="35408290"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14928"/>
    <dbReference type="HOGENOM" id="CLU_034568_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT76280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="418" mass="48299" checksum="40008C71EAA58079" modified="2013-09-18" version="1">MHLISPSSTNAIPMTTKLSYIDHVRKRTQTNPCLKPFVDYLVKEPRFRSRVHILDIHTSPSSVFQAVEIPEEEISRIYQHSPLVCTRIVLVENINSRLMSRIGEALDIDPFFFAGHVITDFKDIEKAPLPPSLATLPSIAAEKGYLNIHFQQVLDLGSSATFGNVAYSLKSVYLHLIGRQLGLGRGCCSMLVKRLKNTSTSICLLLVDLPITRVQAEFQKTFPATRLHGGIEDFEQSASSSALSYQSADKYWNNYSILSCLLYYFGSNHSMFQDVPVTILGLAYYPVRIILNEWNVYTSLVSRYSKYYEYSISDITYRLHNDDIIDLQRWRRRSQQSQHKLTALVDFINFHLEEEPKQKRWTLVLQDIRYLQRQIEIYKQMLAVATSMVQILDSRRSIVEALHIKRLTFCYVELRLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI52</accession>
    <name>S0DI52_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FFUJ_01705</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423886.1">
        <property type="nucleotide sequence ID" value="XM_023575739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI52"/>
    <dbReference type="STRING" id="1279085.S0DI52"/>
    <dbReference type="GeneID" id="35395190"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01705"/>
    <dbReference type="HOGENOM" id="CLU_001771_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1061"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1090"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="121"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="210"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="292"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCT61805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1166" mass="124195" checksum="92343DFAB82D3BC9" modified="2013-09-18" version="1">MAPAYIQVPNKDTNNVALSVPRSPGAGAHLATTTLRVDGMTCGACTSAVEAGFKGVDGVGNVSVSLVMERAVIMHNPQVISADEVKDIIEDRGFDAEVLSTDLPSPVARRFTHNEDDNDFITTTIAVEGMTCGACTSAVEGGFKDVPGVKSFSISLLSERAVIEHDPDLLTAEQIAEIIEDRGFDATIVDSGKVVADKSGKDSDNAGNIAITTVAIEGMTCGACTSAVEGGFKDVEGVLKFNISLLAERAVITHDVTKLSPEQIAEIIDDRGFDAEVISSQPTNEHHSGSSSTAQFKVYGVPDAAAAEALEAELTAMHGVDSVSVSLASSRLTITHQPGVIGLRAIVEAVEAKGYNAIVADTQDNNAQLESLAKTREINEWRTAFRTSLAFAIPVFILNMILPMCAPALDLGRFELIPGLYLGDIICLVLTIPVQFGIGKRFYISAWKSVKHRSPTMDVLVILGTSCAFFFSILTMTVSLLLPPHTRPSTIFDTSTMLITFITLSRYLENSAKGQTSKALSRLMSLAPSMATIYVDPIAAEKAAEAWGKDPTTPKTPGVGGSAHEERSVPTELLQLGDVVILRPGDKVPADGVLVRGETFVDESMVTGEAMPVQKRTGDHVIGGSVNGDGRVDFRVTRAGRDTQLSQIVKLVQDAQTNRAPIQRLADTIAGYFIPAILILGLSTFLCWMVLSHVLTNPPKIFLQDSSGGKIMVCVKLCISVIVFACPCALGLATPTAVMVGTGVGAENGILIKGGAALERCTKVTQVVLDKTGTITYGKMSVVESVLESEWHDNEWRRRLWWAIVGLAEMGSEHPVGKAILAGARQELDIEVDGVLEGSVGEFKVTVGKGINALVEPASAVDRNRYRALVGNVAYLQENGIEVPEDVIEASEQLDSSATKASSKGPATGTTHIFVAIDGKYSGHLSLADSIKEGAAAAISALHKLGVKTAIVTGDQRSTALSVAAAVGIAPENVYAGMSPDQKQEIIKQIQEQGEVVAMVGDGINDSPALATADIGIAMASGTDVAMEAADIVLMRPTDLMVIPAAMDLTRYIFRRIKLNLAWACMYNIIGLPIAMGFFLPIGFHMHPMMAGFAMACSSVSVVVSSLFLKFWKRPRWMDEAAAEQRGGLRWKSGRGIVGWVRETLGRRRAKKEEGYVPLENLETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJD5</accession>
    <name>S0DJD5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable ran GTPase activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_01078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424457.1">
        <property type="nucleotide sequence ID" value="XM_023567941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJD5"/>
    <dbReference type="STRING" id="1279085.S0DJD5"/>
    <dbReference type="GeneID" id="35394563"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01078"/>
    <dbReference type="HOGENOM" id="CLU_028747_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006404">
        <property type="term" value="P:RNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="418" mass="45483" checksum="1ACFDBB220107406" modified="2013-09-18" version="1">MASSDKIFSLEGKGLKLDTAEDLEPHIAPLRSADVEEVRILGNTLGVGACKLLGEVLATKKNLRVANFADIFTGRLLSEIPDAISSLLTSVLNLPKLNTVNLNDNAFGLNVQAPLVAFLAAHVPLQHLYLNNNGMGPHAGILIADALSELHAKKEAARKEGKEVPDLETVICGRNRLENGSMTAWAKAYKLHNKIKVIKMVQNGIRQEGISHLLAEGLSHASKLEVLDLQDNTFTVTGARALSKVVANWTSLQELGVGDSLLGAKGGVLVADALAKGKNAKLETLRLQYNEITSKGIKAFAIAAKDGLPALKRIEINGNILTEDDESIPVLQELLEERKEKFGGDIVNEDEWGVDELEDLEEPDSDAEEEEEEEEEIEPEDRAEKLIKEAEEAQEEPVIPVKDKEVDELAKKLEKTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJI4</accession>
    <name>S0DJI4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424785.1">
        <property type="nucleotide sequence ID" value="XM_023571951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJI4"/>
    <dbReference type="STRING" id="1279085.S0DJI4"/>
    <dbReference type="GeneID" id="35394202"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00717"/>
    <dbReference type="HOGENOM" id="CLU_048127_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="266" mass="30023" checksum="D424DD16F9FD9C84" modified="2013-09-18" version="1">MASSLSITSAININLEEFKRVLNQYPALIKRVSDEKGAKGGQRTLQELDNYRYKDALDAFNSSAKSRPMKLDDIKNLVEWKLRHGKFRPTLMNLVSSNDANDAQEIVKQALEAYKKDADIEAAVGVLTKLRGIGPATASLLLAVHDPTRVIFFADEAFWWLCCHGKQSPIKYNAKEYRMLCSKVDDLRNRLDVQASDVEKVAYVLMKQPAQPDQSHDVAPPKEVRPITAPMAAKKEKKRKVNSNAEIVQDAIHEQPPLRRSKRVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJM3</accession>
    <name>S0DJM3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to carboxyphosphonoenolpyruvate phosphonomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423573.1">
        <property type="nucleotide sequence ID" value="XM_023578117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJM3"/>
    <dbReference type="STRING" id="1279085.S0DJM3"/>
    <dbReference type="GeneID" id="35395512"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02029"/>
    <dbReference type="HOGENOM" id="CLU_027389_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF13">
        <property type="entry name" value="CARBOXYVINYL-CARBOXYPHOSPHONATE PHOSPHORYLMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="348" mass="38024" checksum="4343BEC5F2B6F2AA" modified="2013-09-18" version="1">MSKSIVNSTPYPFQFNPPTLQKPGKPGQIANVTGTLKNVRGKIPSVHASALRTMMLEAHNDPTKILAHCCSYDGLSSRLCEEAGFPMIFLAGYAVSSAYGLPDTGYIAMAEVCDKIQETVRQVSVPVMADGDAGYGSPLNVKRTVESYAHAGAAGIMIEDQTWPKRCGHTKGKSVVSRGEAYARIQAACDARDQGKDIFILARTDALIHGWEEALSRAKEFKRIGVDAVFVEALPDRESMRRCVEEIGIPTFANIIEGGKTENLSAKDLAELGFCAVAYPWTLVAAKLKSIRETLEELKKSMTIGKPPMILSYSEVCEGVGFNKYWDLEERYKFKDEGLVTNSTNGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL64</accession>
    <name>S0DL64_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425216.1">
        <property type="nucleotide sequence ID" value="XM_023573508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL64"/>
    <dbReference type="STRING" id="1279085.S0DL64"/>
    <dbReference type="GeneID" id="35393730"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00245"/>
    <dbReference type="HOGENOM" id="CLU_039765_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494947" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="50"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="318" mass="35364" checksum="1229C89C9956D773" modified="2013-09-18" version="1">MSPTKSLLASILAIAPLALAQDPSCDCYVTKGDSPQYYTSHSFFDFRSLSQYAGVPPLIDSIQGNAEADFSSAFFNWESEFAQTWGPQKWNNGNEEFPMQNTYNNLYIEENNDISPASDTWLTMRTARHNGFQTASEFESLEKHQYVSLRMYARTKGSPGACTAMFTYLNGGSLALVQEADIEVLTKDDPTIIHYTNQPSYTDEGGEVEGAHLAATLPDGLKWTDWAKHTIDWTPDATIWKVNDKEAWRNAFQVPRDPAQLSFNAWSNGDTWTGTIPEGGAAYQQIQWIEVLHGRTEQGSCNRVCSVDEGEAGKAVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLD1</accession>
    <name>S0DLD1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable NADPH2 dehydrogenase chain OYE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425307.1">
        <property type="nucleotide sequence ID" value="XM_023573614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLD1"/>
    <dbReference type="STRING" id="1279085.S0DLD1"/>
    <dbReference type="GeneID" id="35393635"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00150"/>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="368" mass="41407" checksum="EB4812D923FB7F06" modified="2013-09-18" version="1">MTESRLFQPMKIGNIRVQHRIGMAPLTRLRASIDRVPNALMKEYYGQRASIPGTLIITEGTLVSPAAGGGFARTPGIWNKEQVNAWKDITDEVHRKGSFIFVQLFAMGRAATIEVAKDERIDIIGPSANPIEGSPAQPRAMTLDEILEMIQAFVTASENAIKAGFDGVEIHGANGYLLDQFLQDVSNQRNDKYGGSIENRSRLITEILERVVQAIGPEHVGIRLSPWSTFQSMRMKDPIPQFTDIINKASRLNLAYLHLIESRISGSQDYQDHGSEKLDFAYDIWKGTFLIAGGYKLKEAERLVDEEHPDKEIMVMFGRNFLANPDLVYRFKEGLELNPYERKTFYSSDVEGYVDYPFAVRKDAAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM76</accession>
    <name>S0DM76_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_00966</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424563.1">
        <property type="nucleotide sequence ID" value="XM_023569185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM76"/>
    <dbReference type="STRING" id="1279085.S0DM76"/>
    <dbReference type="GeneID" id="35394451"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00966"/>
    <dbReference type="HOGENOM" id="CLU_001832_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000313">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="272"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="460"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="168"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="906"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT62482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="957" mass="108526" checksum="AE075F1C449E782F" modified="2013-09-18" version="1">MAEDREYDGYNPNPKRRRLDTHRQRFQNDSRTSTPHRAQSRYASTPPPRSIGPTEEDSKALDRDWYGGDEFGGHSFGDEAHNPFASYDTWEGQQQETARHEKMTSRFDARRDQRNRENDAWETNRMLQSGVAQRRDMASDFVDDDESIRVHLLQLEPIPAVKDPQSHMAVFSRKGSKVVKEARQQRERQRQAKEATSMTGTTLGNIMGAKEEDGDSALPVPAEDNAEPSERKGNKFSAHMKKADGASNFSQSKTLREQREYLPAFAVREDLLSVIRENQVVICVGETGSGKTTQLTQFLQEDGYGKTGMIGCTQPRRVAAMSVAKRVAEEMEVELGSTVGYAIRFEDCTSKETVIKYMTDGVLLRESLNEPDLDRYSCVIMDEAHERALNTDILMGLFKKILQRRRDLKLIVTSATMNSKRFSDFFGGAPEFIIPGRTFPVDVMFHRSPVEDYVDQAVHQVLSIHVSMGPGDILVFMTGQEDIEITCELIQKRLDALNDPPKLSILPIYSQMPADLQAKIFDKAAPGVRKCIVATNIAETSLTVDGIKYVVDAGYSKMKVYNPKIGMDTLQITPISQANASQRSGRAGRTGPGKAFRLYSEKEFKEDLYLQTIPEIQRTNLANTVLMLKSLGVKDLLDFDFMDPPPQDTITTSMFDLWALGALDNLGELTDLGRKMSAFPMDPSLAKLLITAEEYGCSEEMITIVSMLSVPNVFYRPKERQEEADAAREKFWVHESDHLTYLQVYTNWKANGYSDGWCVKHFLHPKSLRRAKEIREQLLDVVRMQKMELTSCGMDWDIVRKCICSGYYHQAAKYKGSGEYINLRTNLGVQLHPTSALYAGHPPDYIVYHELILTSKVYVSTVTAVDPHWLADLGGVFYSVKEKGYSVRDKRITETEFNRKMEIEAKMADDKRKDEERKQMEEDRTQKKSKKIGADGKKFVTQGAVKKPVIKRRGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM83</accession>
    <name>S0DM83_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425616.1">
        <property type="nucleotide sequence ID" value="XM_023571283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM83"/>
    <dbReference type="GeneID" id="35398806"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05325"/>
    <dbReference type="HOGENOM" id="CLU_1981762_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="126" mass="13938" checksum="2466241468519CF3" modified="2013-09-18" version="1">MRNKACRTTSDFGSASASKNPFALQVEDEGVDSTNPPQQPGQQQKQQGDTPVSSVTGNRFQMKQGHDETTNPLDIDQAKLHDTSWPIEIENVGQFLHTQIEDRFIDGDGGAMDWYMADLFTNALPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMW2</accession>
    <name>S0DMW2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_04894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426015.1">
        <property type="nucleotide sequence ID" value="XM_023571766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMW2"/>
    <dbReference type="STRING" id="1279085.S0DMW2"/>
    <dbReference type="GeneID" id="35398375"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04894"/>
    <dbReference type="HOGENOM" id="CLU_008891_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT63934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="565" mass="61380" checksum="4678C345508A2AC3" modified="2013-09-18" version="1">MASMFEQPRNGTLFLGGQKISGSDIRDQNVLATQAIANVVKSSFGPSGLDKMMVDDIGDVTVTNDGATILSLLDVEHPAGKILVDLAQQQDKEVGDGTTSVVLIAAELLRRGNELMKNRIHPTTIITGYRLALREAIKYLNENVSIKVDDLGRESLLSIAKTSMSSKIIGADSDFFADMVVDAMQAVKSTNNRNETKYPVKAVNILKAHGKSTLESVLVKGYALNCTVASQAMPTRIQDAKIAVLDMNLQKERMKLGVQITVDDPQQLEQIRARESGMILDRVEMILKAGANVILTTKGIDDLVLKTFVEKGAMGVRRCKKEDLRRIARATGATMLSTLSDLNGDEKFEPSYLGYAEEVVQERISDDECILVKGTKAHSSASCILRGPNDFTLDEMERSVHDSLCAVKRTLESGSIVPGGGAVETALHIYLEEFAGTVGSREQLAIGEFAQSLLVIPKTLAVNAAKDAAELTAQLRSRHALSQRIAEGDGSEDEKTIAKKKGYKNYGLDLAKGKVVDEIKMGVLEPSLSKVRQLKSAVEACISIMRIDTLIKLDPEQREDDGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN65</accession>
    <name>S0DN65_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424918.1">
        <property type="nucleotide sequence ID" value="XM_023573146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN65"/>
    <dbReference type="STRING" id="1279085.S0DN65"/>
    <dbReference type="GeneID" id="35394055"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00570"/>
    <dbReference type="HOGENOM" id="CLU_086075_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024526">
        <property type="entry name" value="DUF3807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642:SF1">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12720">
        <property type="entry name" value="DUF3807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="191" mass="21718" checksum="BCD2FF67C6E7954B" modified="2013-09-18" version="1">MPDLALKNQDMPQSNNGSTTNAHVIPNIFTDDLVTFHESHFSHTAVAVFGSEFLDSPSQDQTQDEAVDGNWEEDDDSLGYYPDGVKRTLTDAQIEIFRHSELETLRKEKERAKHLRSKETAPSSEVMDLSDATHISTQTKNMTSSLPTSFQSNKKRKKKKGLQRPRPEPKPDLRKRTWDVVDKGLDSLEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNY8</accession>
    <name>S0DNY8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to nonribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_00282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425183.1">
        <property type="nucleotide sequence ID" value="XM_023573467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNY8"/>
    <dbReference type="STRING" id="1279085.S0DNY8"/>
    <dbReference type="GeneID" id="35393767"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00282"/>
    <dbReference type="HOGENOM" id="CLU_002220_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="586"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1075" mass="118442" checksum="E5B7B7F1A7E1754A" modified="2013-09-18" version="1">MAIRADIEHYDAPVSGGASNQADNAIEKGPVNNESNVKHYVLIDLIHEIAANDPDRAFTYTPSSSDTRDGWKPVTHRQLANAVDYLAHDISKTITKSSDDEVPTVAYIGPNDFRYTAILLACVKAGCKALFISPRNTPAVQLSLFEATNCRYIYTTDSFGSVMQPCLDQRTMEIAMIESIDHLLSVTPDPFPYSRTMEQARWDPLVVLHTSGSTGVPKPVFLKQGILYAFEEYLALPKFHDSPYPFNEWTERASKIFMGMPMYHAAGTYLPLSFIYTGLSAIMPFPNQPLNADTAMEYLNHSGADGAMLPPSVIDELAASEEGMEALAKLKLLITGGGSLSTEAGNMLARRGVVLRNVISSTELFPLAPYSPQDPKLWRYFIFNDELMGIDWQRHDSNEYELVVRRKASDPGNQGCFYNFPELSEWRTNDIFEPHPTLKHHWLYKGRADDIIVFSNGEKLNPLTIEGIVSDHPLVKSALVVGQRMFQAALIIEPIAEAQPRDEAEAKALLDKIWPVIEKANGETVAHGRIAANFVAFADPALPFARADKGTVQRGKTVKLYADFISDLYEKAEMLGDGPSITLDLSNDDALTESIISLFVTKLGVEKLEPDTDFFSVGVDSLQVMTATNLLRGALHRVGIDTSTLAPRVIYRNPTAKGLAEYIQSLRSGANEDDEETKEINQIKAQVLKYTKNLPAPKTGKQAPFDDDQTVIVTGTTGSLGAYMLDQLCRLPSVKKVIALNRSDDGGLSRQPSVNEFRGLTTDFSKVEFLHADLSLPDLGLGQSKYDSLLADVDRVIHNAWPVNFKFTMSSFESHVRGVRHLVDFSSAASKNVPIIFISSIGTVDRWSSPDAVPEKALQDLTLPSMAYGRSKLAASLILDAAAEESSIPTVSVRVGQIAGSRGEKGLWNRQEMIPSMIASSVYLGVLPDHLGGQQEIAWTPIEDIAGLILDVAGITVQKPISEISGYFHGVNPTTTSWPDIASAVKDFYGDKVKLVSAGEWVERLEASAKEENVDFDKNPGVKLLDTYRGMFVVGDEVQPVKYGMERTKSHSPTMTELGPITPELMQNWCRQWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP23</accession>
    <name>S0DP23_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NIPA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426262.1">
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            <end position="393"/>
        </location>
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        </location>
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        </location>
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        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="55681" checksum="260A5EFB38903F85" modified="2013-09-18" version="1">MSTNATKRKFNTLLQGLGSSSAKAANDTSAHETDSPSNRSTTSPGIETRVSGVDAELLQKRRRLGFPDSTAPKAGKRTNLSATLSAIVSRRTQTQDSSKKSTGAPTRYAPTDRGDLLKRLGTFQEITDWTPKPDKVNEIEWAKRGWVCHSKETVRCLLCHRELVVKLNRKVVDGKEVPVLVASEIEDALVDKYADLIVTSHQDDCLWRKRGCDDSLLRLSLTNATTSLAALRERYDELLARKSFLPYEFNLRLPEELNLDHVLSHLPNDFFTKPAAPKEAEAQPNRVALSLALMGWQGLNNARIGAVPNSASCHTCLRRLGLWMFKSKEVDENNEILVPAPMDFLDPAREHRFFCPWANSETQKQAHSQKASGQDLPGWKVLVRTIANEAHLRSVYEGRSPARPRTERSMGAPSTPQKPGTAASINTPTQTPGSVGAGVENAEEDEKERDVKDKERWARLKRVKSLFDTKGSRKLRHSISKSISRPGTATSTKSAKSNGGQAE</sequence>
</entry>
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    <accession>S0DPI9</accession>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
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                <person name="Smith K.M."/>
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                <person name="Proctor R.H."/>
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                <person name="Freitag M."/>
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            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPU1</accession>
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        </submittedName>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
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        </source>
    </reference>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
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    </evidence>
    <sequence length="380" mass="43197" checksum="1B41B2265E38154E" modified="2013-09-18" version="1">MPPRETAKAKRERLAREAEEARLAEEVEAERIAAEEAEAERIAAEKAEADRTAAEKAEEKRIAFEKKLEADRIAAQKKKAEEARIAAEKFEAERAESKQRHDELMEMLAHAEKEMDDEALEEDRIIKKEQLERQLRILKRNDDEDYRAAKEALRRDFGDHTFKHLAEEVNGIPTPTFDYKAERPPANPQLTIWAYMNALKNCSYKGLTHVKFDENELPEEPNSLFLRKKKGKNLEAEYTLKFSSQNADAMLRHLYGFVMPESLPCNKCMSGNGALAHCRVTAPSEGCANCLWNHSGPNCSYIRATPKKRKAVSDAISVTSGSSSSSSDSEEDPMDTLKDFTEKECRRLSRFFRKVTDHKKKKKKSKGKGKSKSKKAKGSK</sequence>
</entry>
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    <accession>S0DPY7</accession>
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    </gene>
    <organism evidence="3 4">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023572467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPY7"/>
    <dbReference type="STRING" id="1279085.S0DPY7"/>
    <dbReference type="GeneID" id="35397749"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04268"/>
    <dbReference type="HOGENOM" id="CLU_256719_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484806" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="901"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1246" mass="146448" checksum="EA612A7AA3870171" modified="2013-09-18" version="1">MKLADTILVALQASMGLALVLPNDDMKKELTQHKHNDAEPDEKKFHGYETITKITSHRYFGVKDHKHHHEEKKHDDDDTDDDEDDDGKEEHVNQPQKAKEKHNNDDDDHKEHHSHDFKKKQHDEEDDDKDEDKNKNKKEKPKLTFPTEEFKKAKKKHEEEFPRLKDHVSETPKSDDKSKSLEDAVEKIKKETKQKLPFENIVLETPKRYNKHRNEEKQVKEDKKEQTNSKDGKMYKFIHRNGMDVKRDIDINIHAPTYKIYHNSDKKHGHGDAELIKIFHVSSEESTHETKDHKYKHDGEQKHKEPTKEHHSLPKSHHKNVESKNYDGHDKGHFGSEKKYPQSSKGRNQTQGHRHTPVGRPSPHDNRYPDNQNTHHGDKPKNGHKKSDQAEKEKNDTLRRIIESLADLLAKKEAPKHHLKKTHPSEDDHDSHHESEKKHHSHKRPSYPYKEHAEHKHDDNKKHVKLSQDSSSHYEPGYNHEEVDSHHAKKQNAYYHDHEDSKKGQYSHNKPTSQYEKKINDKHDDEKNYIKVIKDRVSQHKPTLHNEKPDHHHHHHDKDNEHPKRPKPQHNHQEAEHHWDSKKSEDYYPYNKPKHQFEEQSKHKHDDDNERGPFYQRLKMDRKPINYFPKSGHHKDHEDETKAYKAHQSRPETHIKRSSNLVPKLNTTQILNLEALSPQDRKRIAMGLPLDSQTRKEFGEFKDCTPKLITKLNVMYARIVDDPKYAHFIKYLNTERKFRNRKRSASVLTPEMLAKIEAMPPMMRTLAADQLDFGPELKKEFVKGGKLSPGLIRKLEKEYERIAKNPKYKKILEKLKSNGKRAAPNPPPPKIPNEMLKKIEAMDPILRRFLAEKLDLPAKLTDEFVDCGKLDQAMIHKINWEYARIHKDPKYKKILQEFNTKSRRSKGQDENTKDELITLTDDEKEKVAKPKEKVEADEPQRLTEQQLAVLANMPKFHRREVAKKIGMPKDLTKWFVKTKKFTGENLERLNEEWIRVQLDPKYEDVVKSLKHLAVKGNNKARKDKIRKRSVHQLTEKELERVLKLDKYERQALARRLGLDQSLAREFINASKPNTDLLEKLNEAVSKSVGTPQYQELLKLVGKEFPKPKNEELKLESIKKEVRLEIAKSLDFDEFTRDEFLEAKELKGRLLDKVTKYWGVKRMKNAEQGKDDIKHSEVINKLLGSALDKAGQPGDDLRSKGTDGKKITEAEQKMKDKLEKTKENGWCDEFVSELEDAWGPKKEKEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ24</accession>
    <name>S0DQ24_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to low affininty zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_04083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426755.1">
        <property type="nucleotide sequence ID" value="XM_023572673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ24"/>
    <dbReference type="STRING" id="1279085.S0DQ24"/>
    <dbReference type="GeneID" id="35397564"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04083"/>
    <dbReference type="HOGENOM" id="CLU_027089_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF55">
        <property type="entry name" value="MEMBRANE ZINC ION TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT64674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="552" mass="59623" checksum="D714F8522A3AB7D6" modified="2013-09-18" version="1">MICLSKADESFYQRLTWNQAPSPLAAMNTTRQDLNGISNLREHVDAGQDDGSGGTSGSLLNSHDESNQAGSHPTEPFLGSEKDAGRLSRISGLSSYLKTVDGGDDQIRLHRGTLSSCASHIWSWTVWVLSVLVVSTIISSWNSPASVPAAMTSTPKAHESIPVQASPLRKRSTCETGGVNKAEYNTPLHVGALFIILCVSTLACAFPIMATKFPGLRIPTRFFFAVRHFGTGVLIATAFVHLLPTAFISLGDPCLSSFWNQDYPAMPGAIALAAIFLVTVIEMVFHPSRHVSPAEITSGTDNDARNCNSNSGGCMGGTGMLPIRDMGPIRGRSSSIGQGLSVLNSRDERLENLDEEACEDDDNAQSGRKNLEETSLEAVQMPSLTPEQQQRKELLQCVLLELGILFHSVFIGMALSVSIGNEFIILLIAIVFHQTFEGLALGSRIASIKWPQGKMQPWFMALAYGCTTPLGQAIGLATHTLYSPNSETGLIVVGVMNAISAGLLTFASLVELLSQDFLSDESWRFLRGRKRIYACLLVFFGAFFMSLVGAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR30</accession>
    <name>S0DR30_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426991.1">
        <property type="nucleotide sequence ID" value="XM_023572956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR30"/>
    <dbReference type="STRING" id="1279085.S0DR30"/>
    <dbReference type="GeneID" id="35397309"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03828"/>
    <dbReference type="HOGENOM" id="CLU_746054_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT64910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="372" mass="41548" checksum="FECD97E5D0143EB6" modified="2013-09-18" version="1">MAIDGLYASLVYVDETNSSTTYVFNTKPQSLMRWEAILDFRFEIQRYWQSLVNIAQKQDLPGLHILLESFPTSAHLYDAAIFTFRNTLTGSEPGDLHGIFALCSLSYLALRHSQKIGKPAADNIFYDINIWRDLIGDPQNRQLFSSLIQRLWDDMTASCYQTEQFLDPDSLVNGQDCISSQSAVMQDISSLGDFADPFWGGLFEVPGSLQRPNFQMSDTTPGSHSTVLDAAKPQLSTGDLRQSAVMNILTSFIANCGDLVDIFSGQAATAKGPHSDVSLEVKNFTQALRRHDCFGDPSSRGILAVVDRFVDLNYFQNIDEVQDYIIIVGKEILSSGQTLAKVCKAVYSSTDMIKMPQVARRQRADRPPERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRN2</accession>
    <name>S0DRN2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_04233</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427187.1">
        <property type="nucleotide sequence ID" value="XM_023572506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRN2"/>
    <dbReference type="STRING" id="1279085.S0DRN2"/>
    <dbReference type="GeneID" id="35397714"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04233"/>
    <dbReference type="HOGENOM" id="CLU_031981_2_1_1"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902767">
        <property type="term" value="P:isoprenoid biosynthetic process via mevalonate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT65106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="462" mass="53460" checksum="0BFA8F25293F8FAE" modified="2013-09-18" version="1">MGYLYYLFHPYQLRSIIQWQVWHDPVHQRDPSTESPELKECFRYLDMTSRSFAAVIQELNHELLVPITLFYLCLRGLDTIEDDMTIPLDKKVPLLRNFHITMEEDGWQFHESQEKDKELLEHFDVVVTELKKIKAPYYQIIQEMTRKMGNGMADYAQNEEMIKNGVQTIEEYELYCHYVAGLVGEGLTRLFVESELANPKLAERPSLTESMAQFLQKTNIIRDIHEDWQDGRRWYPKEIWSQHVDKWEDMFDPSQQTKALECVSAMVLDALKHSEECLFYMAGIKDQSVFNFVAIPQGMAIATLELVFRNPEVLKRNVKITKGDACKIMFECTQNLYTVCEVFKRYARQIAKKNDPRDPNFLAISAQCAKIEQFIETLFPKQDPKKLSMTQAQVQNKEPTMDGGETLVLFGVVIAALVCISGLMIGTAWIFGARFDTIFREASVFLPGGEKATPMITGHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSA1</accession>
    <name>S0DSA1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">FFUJ_04528</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426348.1">
        <property type="nucleotide sequence ID" value="XM_023572175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSA1"/>
    <dbReference type="STRING" id="1279085.S0DSA1"/>
    <dbReference type="GeneID" id="35398009"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04528"/>
    <dbReference type="HOGENOM" id="CLU_028820_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000233">
        <property type="entry name" value="Probable glucan endo-1,3-beta-glucosidase eglC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 24" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485240" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="24">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CCT64267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="403" mass="42228" checksum="93846AFD44E31B6D" modified="2013-09-18" version="1">MPSINSLLTMALAGSASAAFQGFNYGSTFTDGTVKAQSDFENEFRTAAGLEGTGGAFTSARLYTMIQGGSTNQPISAIPAAIKTKTSLLFGLWASGDGFANEIAALKNTVDQYCGQLDDLVAGISVGSEDLYRISPTGIKANENPGTNPDVLVDYIKQTRAAIKGTCLESVPIGHVDTWTAYANASNNAVIDACDWLGMDAYPYFEDTKNNPISEGANLFKAAWDEVKAVAKGKEIWVTETGWPVSGKTYGKAVPSTKNARTFYEDVGCPMFGDINVWWYTLQDSAPQTPNPSFGVIGSELTEKPLYDLSCDEKSKKGTLVSRSNDASGNVEHRFVSPSFATGNYTNGTVPVVSGTATSLVPTPSSTSGKGGSATTPQPGSGAQQLNSMGAAAVAFILAAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSD4</accession>
    <name>S0DSD4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_01525</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425554.1">
        <property type="nucleotide sequence ID" value="XM_023577739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSD4"/>
    <dbReference type="STRING" id="1279085.S0DSD4"/>
    <dbReference type="GeneID" id="35395010"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01525"/>
    <dbReference type="HOGENOM" id="CLU_046932_1_0_1"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT63473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="207" mass="23168" checksum="56FDFC5C5A0D3DFA" modified="2013-09-18" version="1">MATNITWHPSLSRKERNETRGQRGLTIWLTGLSASGKSTVATALEQHLLHLGVAAYRLDGDNVRFGLNKDLGFSEADRNENIRRISEVAKLFADSSTIAITSFISPYRADRKVARDLHEQATQGGEEPIPFVEVYVDVPLEVAEQRDPKGLYKKARAGEIKDFTGISAPYEEPENAEITIKTHENSVEECVAQIVQWLNEKGYLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSG1</accession>
    <name>S0DSG1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to suppressor protein PSP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425579.1">
        <property type="nucleotide sequence ID" value="XM_023571419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSG1"/>
    <dbReference type="STRING" id="1279085.S0DSG1"/>
    <dbReference type="GeneID" id="35394250"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00765"/>
    <dbReference type="HOGENOM" id="CLU_011715_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="637"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="894" mass="96815" checksum="2D50D2D115CF8BFC" modified="2013-09-18" version="1">MSSGPLKTGPSSRLGQGSHPTAPGNNQSLLLEKLHARTSTPDSEALASSDDEGEHRYESATAASHSASQPPRPVRRPSWLNETSQTLGRPRRGSIASNSMSPTTSHPSTPSGEAGGAWGSHSASSVMGRGVWRTWLFMGLSEVLPSPTSTMPPGGGNSFFGSDMQTSPVSRDPAPNSQIPFAIPLHPTPKTYRSQSYSVGQLDPESTATPPTMSSSAIMGRARYPALQHRPSRPSMLSEMANDGSMLGKVKEVEDDDDESPSESMQSSFHQSDAKTIEMLARENAMLRQQQQQQQQQQQQQQQQQQQTQYNNARIRPRAVTGSSYPANGYPIRDTVPEESDYAIDELDEANESGDMLAKRALSRRMSEYGAGSLRSPFENNRKPENANLKKALWSSSLGFNPSDISQSRRHSFANMPTRQGSISSIPDAAALEPSALDMQQSQEYPPGYPDPAAFSASSHASQYFGVGGGANIGNAYQTGFANQYGSPYGLPTAYGNRAPSPHRNVYSIAQPRHNQLLHIVLFKCARADVFYIQEGTGLNVKPGDLVIVEADRGTDLGTVAKDNVEWQVAKELKEHYAEEQYKWLMMYSQNAAVAQEGSSAGLLASSTGLQGSAVGGMGPPSQHHAQEPNAGELRPKLIKRLAQNHEIQALRDKEGQEAKAKRVCMQKVKEHALNMEILDAEFQMDWKKLTFYYFADSYINFNSLVTDLFKIYKTRIWMSAINPASFASPTLGIQAPSGIGPGAVNANRGAGGNDRRQNQQVQESHQASAFPGGARDGRGFRPAPTFSQPFGNEGRLAQPSGYPPSNYPYGQFANPYSNPRSNVGYGASSGAMPGAMEGYPVGVPQLGEYTSMRQRFPNPQSGPSPAPHSQATSPLAPQNDWVGSFQGLSLNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT36</accession>
    <name>S0DT36_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_02520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427646.1">
        <property type="nucleotide sequence ID" value="XM_023574261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DT36"/>
    <dbReference type="STRING" id="1279085.S0DT36"/>
    <dbReference type="GeneID" id="35396002"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02520"/>
    <dbReference type="HOGENOM" id="CLU_048802_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT65565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="317" mass="36777" checksum="A1531CF50E497DC8" modified="2013-09-18" version="1">MAFKRKPSSSFGLERRVRPRREDEWVEEPESQGSSSEDDDDDEVEEEGIRGASDDGDDDDEVEEDQEFEEGSEHESEPEQDTPKIDLSSVSFGALAKAQASLPSAGRKSKLKKSTDEDTSKTETPAPRKSTKSKDDPKPKRSSKHAPQEQTSKKPVSRRREILPDNRRQYRDPRFDPLVGRVDEEKASKAYAFLDEYRDKEMADLRAQIKKTKDSYEKDNLKRQLQSMESRKKANMRRQEEERLLKEHRQKEKELVAQGKTPFYLKKSEQKKQLLVNRYEGMSKGQVDRAIERKRKKVAGKEKKELDFLQRGSRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTL3</accession>
    <name>S0DTL3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable developmental regulator flbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425989.1">
        <property type="nucleotide sequence ID" value="XM_023571736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTL3"/>
    <dbReference type="STRING" id="1279085.S0DTL3"/>
    <dbReference type="GeneID" id="35398401"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04920"/>
    <dbReference type="HOGENOM" id="CLU_013365_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="427"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="550"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="718" mass="79495" checksum="86956663861AEA09" modified="2013-09-18" version="1">MATLSQHQRPTVHSASPSDTPLALDHDQDQDTTTNTPRSSISDRSPLPTPLPPAHINTSATSGNSSTSTSTSNTNQPTYVPYHPQQSHHRHTASSVSRLNNRSSTSLFALAASAFDRTQNAIAAISEPAIRPRQSSGALSRLSLLTSSSPSSEPSSPDKYHRLRSSSNQSLSSGAYLDSKVAPQTLQANNPPSQPYTSTDPNLPPPIKSSTANKMHQTSSRLLRMTDDDRPFTKDFKDLFSTLVVSLLPLSAHRVRLTKVEYTFLSEDAINNLGSLKFSQSNRMPDPKDPSRIVTTTTTTTFSMAKDMARSICQRFLEARFIESADGKYQQVYTMKGSVWQLTPKGITVLDRFCARNGIQQKQVSELANLASTQLVLLERDPQTDKLLHDQGTIEVIFRRFAGSEGRNIKTTVNAADSDSLHDYRDGLTGVKMAAERKVNGKTYRDTFTGKAATDWLMDCSTIVDKRETVEVATLFVEYELMEPVAQDRAYMSQNPGCNLFQPTKYAIYQLSQRGKDLVSGAASRGRPSESEGGAASQRNGITRDSNTQRLDKILNDPALRLLFREQLRDTHCEENLSFYQDVDEFVRSCKAATRAAQKSPNTNAMDGIKEIMASAYGIYNAFLAPGSPCELNIDHQLRNNLATRMTKAVGQDVAMIDTLQEVTSLFEDAQNAVFKLMASDSVPKFLRSPKYEQQLRNYEFDVVGRGPERSQSRSNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTU0</accession>
    <name>S0DTU0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426893.1">
        <property type="nucleotide sequence ID" value="XM_023572839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTU0"/>
    <dbReference type="GeneID" id="35397414"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03933"/>
    <dbReference type="HOGENOM" id="CLU_727702_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495182" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43609" checksum="BEBE0474CE614C40" modified="2013-09-18" version="1">MRLSSALLLYLATSAISAKPKLSDSWEIDDSCDVPRLEKLEDAHSEIVELLAKVTRDLAHVQQPRPATRWGKSNWNRISGNLAGLFGLQPSDAIIENGYDPSEQYFSQVLYTYDRMYQALVKGRTVPENGYSGKLGNQNQPSKPLLLCGDTRAWEFFDKDAKDKYDKSKTVAEVFPDAAKAGGAFIRANRYLGATPGETHPAICNGIYGMTLQRHDLITICDNTLELDDEKWPVRDGGKVVNGTDLDRDHFGRQSLVRVMLHEFAHYYGSRMEGNEFKGLPDQQAVDTNACLLWIGSTGKQVREPTTVGGQNLPRQVVYSLRFCTNLNINQTTNKKTGKFEKDGALVAGTLGITGPSVATWTAETYAYFPIVSYLDKWEWVTTGKARPLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTV5</accession>
    <name>S0DTV5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_03914</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426908.1">
        <property type="nucleotide sequence ID" value="XM_023572860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTV5"/>
    <dbReference type="STRING" id="1279085.S0DTV5"/>
    <dbReference type="GeneID" id="35397395"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03914"/>
    <dbReference type="HOGENOM" id="CLU_048466_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT64827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="363" mass="41373" checksum="60ED02B8AA942B79" modified="2013-09-18" version="1">MSRAGVSIRHATDLNAPPPPDQDETCPVCKTTRYFNRDMEFRINPECYHRMCKTCVERIFKDGPNQCPYAGCHKTLRLRGFKTAFFADLAVEREVDIRRRVAAVFNKVEEDFETLDDYNEYLEMVECLTCDLVYGTDEERRKAEAQLGEWEAKHKADIERNRRLARETDDARKRRIAAEEEEARQRRLREQQEELEEKANAKRFREEMLDSLQSAETGRASEAMDKIMLKKRGHNKRDAALGAAGSSGLSIRGLREKKAVVVDNKPYDPYGGVRVMPERVDLAPEKLATYSNEWVEITRTKPEYKAGGYSPDEYLTRVLFEAFSGLGVFVDEEKVEKSVATAGAKEAAATGDTGGIMDVDDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUW0</accession>
    <name>S0DUW0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to mitochondrial cytosolically directed NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427253.1">
        <property type="nucleotide sequence ID" value="XM_023573783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUW0"/>
    <dbReference type="STRING" id="1279085.S0DUW0"/>
    <dbReference type="GeneID" id="35395575"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02092"/>
    <dbReference type="HOGENOM" id="CLU_021377_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="70"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="8">
        <location>
            <begin position="518"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT65172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="581" mass="64653" checksum="61C17406AC84EA41" modified="2013-09-18" version="1">MASSRLLRSFWQSLARPRSRFLICRDVAVASSTSLSTAARPANTPQHNQGTTDNSEIKATYTEGRKKRERVVVLGSGWAGYALVRNLDPAKYERIIISPRSYFVFTPLLASTSVGTLEFRSILEPVRRLQPDRFHQGWADDVDFTNRTIRVETNPDADEINSRTLPPATQSSPHNDGRDSGSSAVSVIQTPSSGSVKETLTKRKGEMITVPYDKLIFAVGAYSQTFGIPGAREHANFLRDVGDARSIRLRILQCFERAELPSTTDEQRRKLLHFAVVGGGPTGIEFAAELHDLIHDDLARIYPDLMPFVGITVYDIAPKILPMFDKKLSSYTIDTFRRQGIHIKTQHHLQSICPDEDGKGGLKIKIQEYDDEVGAGIVVWSTGLMQNPLVARLVEYRLVEQDIRAPVTPEEQQLCKQQTWHIVKAEKSGGLVVDDHLRVRVSTGSAQAIDSKSGHSAPNDILPEVYAIGDCAVMEREALPATAQVASQQAKYLAKALNKYGSCEAVGNKSKPFLFLNLGTIAYIGSWRAIAQSSSEGLTGRLAWVLWRGAYITRSMSIRNKIMVLVHWIMTWLFGRDISRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVB5</accession>
    <name>S0DVB5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable succinate-fumarate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_03439</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428491.1">
        <property type="nucleotide sequence ID" value="XM_023575287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVB5"/>
    <dbReference type="STRING" id="1279085.S0DVB5"/>
    <dbReference type="GeneID" id="35396921"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03439"/>
    <dbReference type="HOGENOM" id="CLU_015166_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="115"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="219"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT66410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="323" mass="34988" checksum="CCAD35D851F07979" modified="2013-09-18" version="1">MASKNGNGKKQPPSAAVNLIAGGGAGMMEALACHPLDTIKVRMQLSRRARQPGAPKRGFIKTGAAIIAKETPLGLYKGLGAVLTGIVPKMAIRFTSFEWYKQILADPTTGAVSGKATFIAGLSAGVTEAVAVVTPMEVIKIRLQAQHHSMADPLDVPKYRNAAHALYTVVKEEGFGALYRGVSLTALRQGSNQAVNFTAYSYFKDWLKKWQPQYENTNLPNWQTTLIGLVSGAMGPMSNAPIDTIKTRLQKATAEPGVSAWTRITRIAGDMFKQEGVHAFYKGITPRIMRVAPGQAVTFTVYEFLKDKLEKSNISLVGGKYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWU2</accession>
    <name>S0DWU2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_13202</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429105.1">
        <property type="nucleotide sequence ID" value="XM_023575858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWU2"/>
    <dbReference type="STRING" id="1279085.S0DWU2"/>
    <dbReference type="GeneID" id="35406656"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13202"/>
    <dbReference type="HOGENOM" id="CLU_004174_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008957">
        <property type="entry name" value="PRK12300.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="73"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="217"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="839"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="986"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT67024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1124" mass="126740" checksum="52B45C87EBEB0C72" modified="2013-09-18" version="1">MASTDSVPKAMEALNISKTKELKGAGPTSSTTEKRDTLIALEKKYQQKWQDEKVFEANAPTTDEVPLHSIPAAELREQQPKFFGTMAYPYMNGTLHAGHSFSVSKVEFAAGVARMQGKRTLFPMGFHCTGMPIKACADKLVDEVKMFGQDFSGYKDDEPVVEEKAPIAKQTKEDITKFKATKGKAAAKAVKMKYQFQIMQAIGIPAEEIHKFADPQHWLQYFPPLCREDLTNFGCRIDWRRSFVTTDANPYYDAFVRWQMNSLRALNKIKFGKRYTIYSIKDGQPCMDHDRAEGEGVGPQEYTALKIKVLEWAPKAAETLKDKLPDGVNVYQIAATLRPETMYGQTCCFVGPKITYGIFKVNESDYYCMTERAARNMAYQGIFAKEGVIEKVAEIIGSDMVGTLVDAPLSLHKEGVRVLPMETVLPTKGTGVVTSVPSDSPDDFATVSDLAKKADYYGIQKEWAELEIFPIIETPTYGDLCAPFLVKKLKIASPKDTKQLEEAKELAYKEGFYQGVLKVGEFKGEKVEVAKPKVRQQMIDAGQAFAYSEPERKVVSRSADECIVSLMDQWYLDYGEESWKKTALDYVDNGLNTYTPEVKNSFEGVLNWLNQWACARSFGLGSKLPWDPQFLVESLSDSTVYMAYYTIAHLLHKDIFGKTKGSANVEPEQMIDEVWDYIFCRRDLSDEIVTGSKIPKETLEKMRREFEYFYPLDVRVSGKDLINNHLVFSLYSHLALFSQEYWPRSIRANGHLMLNGEKMSKSTGNFMTLRDLTEKYGADASRIALADAGDGVNDANFEEDVADTNILRLYTLKEWCEDIVRDQDQLRTGELNSFQDALFNNDMNAVIKEAVEQYANTNYKLALKAGLYELTSARDFYREACAAAGIKLHRDLALRYIEVQALLLAVVAPHWSEYIWLEVLKNKGTIHNARFPEIREVDASLSAKRDYVRTTASNVNSAEGLQLKKKAKGKETSFDPKKPKQLTIFVTDKFPAWQAKYIDLLKEMWNVEAKSVNDKELNGKIGKMGEMKKAMPFVQNLKRRLQAGEPASVVLEQKLAFNEKETLLQMVPGLKRTSGLVACHIISVEEGSKKGFNLGDGKEVELSVPTAEHAVPGQPTFHFENVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXN8</accession>
    <name>S0DXN8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to protein transport protein SEC6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_13420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429306.1">
        <property type="nucleotide sequence ID" value="XM_023576103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXN8"/>
    <dbReference type="STRING" id="1279085.S0DXN8"/>
    <dbReference type="GeneID" id="35406874"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13420"/>
    <dbReference type="HOGENOM" id="CLU_011776_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000005">
        <property type="entry name" value="Exocyst complex component Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="752" mass="87299" checksum="30EE3AB83ACC2FA5" modified="2013-09-18" version="1">MDDTPAPKLSELLRHPDDLDKIPALKLEFSRKKGTVDGQLRSGLREQLETTQSGMTGLSDGQKTVQMIKEEMIKIDKLCSESQNMIKDFASINLVSQAHRNFGAVETMRRNLETFNDRISRVESMLREDDEDSDNMPNLLPCHYELTQLRNIRDDAMEQIQRAEDESLEATLVDYFSRLDDTIDWFDEHVGIIALNLINLVVQDNNGLVVRFAVVMEAEESSDQRVLALQEALKDHKEMATRFQSITDGAKKVRGYKEKFIQAIRLSAEQQFEGAKEEFLEDPTKLDKIMKWYFNDLNVVKVGMSHLMPKKWNIVKTYAGVYHQLMHDFLVGMVDGNEASSAHTLEIVGFPEKYYRKMAKIGLKQEELIPHVIDNREAELVRDFRELIIKFLDEWIDRIFAQEKRDLAERNVEGSNLDQDEYGYFRTKNFVALWRMLREQVDTAANSQRADVVEGVIDAMFARLRTRQQSWQAMLEDEAIPYEEGKIPELEGFQALQDWLVATANDQIACIDDNEDENRLAYLSSFRRLVEQHVTPAYLERIESEVNTLRDGYVDFSTWCINRFAQLIFSVDFGTVMPDFFTPRWYTTTAMKQMVVTFEEYVNDYRHVLHHSLVDIFVEIFAEELLVRYLSAVRNKGAKFRRTDPFQDKLFNDISTAFECFSTLPSPDIGASIKETWRVTEHFLRLLTADRDAIVDAYVTFKMAYWDLNLQWVEAVLKSRDDFERSWIGAVKKEAANIDSGRGPETIMSRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY19</accession>
    <name>S0DY19_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429431.1">
        <property type="nucleotide sequence ID" value="XM_023576256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY19"/>
    <dbReference type="STRING" id="1279085.S0DY19"/>
    <dbReference type="GeneID" id="35407011"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13557"/>
    <dbReference type="HOGENOM" id="CLU_043566_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="296" mass="32814" checksum="7FAABD853EFBBC8A" modified="2013-09-18" version="1">MSTIASPRDPPRRTPTNSNRPSFETSRSALASPVLTQGPTQPPGPPQQQQRKTSSNRAALREYYNLRASAPRIEIPDSEVPATEIDAPDFNADEYVAKIVEKSSLEELLRLYTRVVGEVRALDAEKKALVYDNYSKLITATETIRKMRANMDPLNPMASTLDPAIAQIYSQASSIRDALRETVPSPDSEEGKKRDAATRQQRTKELAAQALATPGRLRALVNEGKIAQARKEWVMPRKLLESWKEKGLGGSDVEECIEEGDEALRPADNKSSASSPRISRDERRSRDSRASKDGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYB9</accession>
    <name>S0DYB9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429610.1">
        <property type="nucleotide sequence ID" value="XM_023576094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYB9"/>
    <dbReference type="STRING" id="1279085.S0DYB9"/>
    <dbReference type="GeneID" id="35406866"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13412"/>
    <dbReference type="HOGENOM" id="CLU_034385_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="107"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="467" mass="52635" checksum="BA0F0CCA7A40D5E6" modified="2013-09-18" version="1">MSFSGRKFSINRHTGAPKTLTRRFSTTEPSTNEFQSKVHRQFRNAHEGHMPHAGLDASRSSTGVIWCTERASEYGYLEDPESWANLGQGAPEVEDDIEGCFPRPETINISMAGREYGPTAGIKPLREAVAKLYNEEHRQGKESQYTWENVAIVPGGRAGLIRIAAVLGNSYLSFFLPDYTAYNEMLSLFKNFAAIPVPLAEEDGYHIHPDKIAEEIARGTSVILTSNPRNPTGRVIANPELAEIQDICRDRATFISDEFYSGYNYTSNCDGSTISAAENVDDVDEDDVLIIDGLTKRFRLPGWRIAWILGPKEYINAIGSCGSYLDGGASHPFQEAAIPMLEPSLVKKEMIHLQSHFRDKRDFVVRRLREMGFIIKYVPDSTFYLWLNLEGLPESISDGLNFFQACLAEKVIVVPGIFFDLNPSRRRDLFDSPCHHFVRLSYGPRMDVLKMGMDAIERVVQKHRKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYN0</accession>
    <name>S0DYN0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429770.1">
        <property type="nucleotide sequence ID" value="XM_023576636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYN0"/>
    <dbReference type="GeneID" id="35408056"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14676"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="262"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="456" mass="47746" checksum="D350FF88313E2671" modified="2013-09-18" version="1">MATNTIAQSVTTSSMNPSRQGDAMEMSSLSQSPFNTDENTARNEEEPPEHATSAIPDGGYGWTIVASCFILLFWINGYTTAWGVLQAAIVQSPRLHTNIRTITFVGSLYMACMVAFGLISVRLSREYGIRITSVVATIFFGSGLIITSFTLEHLAGLFCIAGLLVGLSTSLLYTATNTMPTQWFSRRLGTANGIVKAGGGVGATVLPLATQAMIDKVGLQWTFRILGASILVTGIPCAFLLTELRRGGATSRFDWSQLKSMPFLTLTMSGAVGVFALFVPPFFLPVFARSIGLSASTGAGLVAGFGASTAVGRLFGGWICDRMGAFNSLALAALINSVSMLAIWPVSSSLPPLFAFAIINGCANGSFFVALPTAVAALAPGSAAASISLMTSFWTPGYLMGAPLAGILIDAAGASEASSIEPYRAAIFYAAGVGSAATFLIVVSRLILSKKLIKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ39</accession>
    <name>S0DZ39_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to 6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428728.1">
        <property type="nucleotide sequence ID" value="XM_023575566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ39"/>
    <dbReference type="STRING" id="1279085.S0DZ39"/>
    <dbReference type="GeneID" id="35397170"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03689"/>
    <dbReference type="HOGENOM" id="CLU_018354_9_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="489" mass="55694" checksum="ACBE9ADF01B8A67A" modified="2013-09-18" version="1">MSDDRFYTTTPKYSKKVLIQGDPDYEKCRRMNPTAHKIERFPAEIHIPETPAEVAKALARATELGVPIGVRSSGHIFHFPALWHGGILIDAVNLNRRIDYDPVTKEICFGPSSRVEELAAKLKEVNRFFPHGHAPTVGSAGFMLAGGQGWFVRGWGATNQTWITKIEMVVPDGRTLIASRTENQDLFWAARGSGMGFFAVVTRFWGRTIERSTMWEKTLKFVINDDNYMALMSWAIERGRDTPKYGTDLNLTIDYREKYDQAYTTDDVPPNATLVLTLNNLCYTDTQREARTLLSAYDRITPEVADFLIESKPVQVRTFEEVFARKRTFLGNAGQERWSINSIMNDPDVPLARLLEGIRPAMLKLPTRVSSVFICHCDIKPDEDDACLSLPQDLYISTLTGWTDPKLEPAIMQPMRDYYRQAFPVAVGQYITDIDINCEDANSKVMSDTALAKFLRIREKYDPKELFPTYKAFVKTSEKINKLQNKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZB5</accession>
    <name>S0DZB5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429999.1">
        <property type="nucleotide sequence ID" value="XM_023576840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZB5"/>
    <dbReference type="STRING" id="1279085.S0DZB5"/>
    <dbReference type="GeneID" id="35408228"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14850"/>
    <dbReference type="HOGENOM" id="CLU_566251_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18647">
        <property type="entry name" value="Fungal_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="7"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="482" mass="53430" checksum="8987407E42481484" modified="2013-09-18" version="1">MAMENGDKPWFDDDDEGEDDEDMHSHGTCGAGKALGTRFGVSKKATLIVVRMHEVTSEEFQAALELILADLEDHPERQKNSVVTMSLTLGQDWEEDDNLPDFTELFQKLFAMDVPLVCISGNIEEGFEEPEVDEYPPLMEGPDLPLIVVGSVDSTGNRSEFSKGGPHVTLHAVGDPIECLPRDSKDPVERAGTSYAAPQVAGEIANLLSYEKVPFDTNDGNLVKNLKTYLQSDAASWERYPGIRCNGLETDRYVEQEEVKHLIEDEFCPEVGSSRGLRRQGSALSRTYNIDTPNKVTLSVSLDQGHSVTGCVKYLMMTMYNCYRVDNDPSDYKGGGQTIVGDATYEVYPGSLRSPSKYGKQAGCDSTYKFTFNEYWVWGHGWASSDHGEALKKEIKGCTLLPDTWKFTYDIGEYGREWTARFRTGVFQKSCVGDAVGKASGIGDFGCAGSGKWILDIAKNSAYLESRVLPRAFRFGLFIETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0G6</accession>
    <name>S0E0G6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430210.1">
        <property type="nucleotide sequence ID" value="XM_023577086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0G6"/>
    <dbReference type="GeneID" id="35400371"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06894"/>
    <dbReference type="HOGENOM" id="CLU_2277732_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013039810" evidence="1">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="102" mass="11298" checksum="9965B3908DEE8885" modified="2013-09-18" version="1">MQIIAFISYLAVAAAATDVITARVYNQKNLKGSHEDVHGYGCGNVGSSKFKVNSIHLRRSTFCYLYEKKNCKGSSIYVSRDVNDLHLDTVNSVHCVNNPDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>S0E156</accession>
    <name>S0E156_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_13627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429498.1">
        <property type="nucleotide sequence ID" value="XM_023576333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E156"/>
    <dbReference type="STRING" id="1279085.S0E156"/>
    <dbReference type="GeneID" id="35407081"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13627"/>
    <dbReference type="HOGENOM" id="CLU_007426_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="701" mass="78468" checksum="57ABBA8860F82094" modified="2013-09-18" version="1">METHQAQSNTQTRKREKPILSCTFCRGRKLRCDRQSPCGACTRRGKPTECIFTCSEQERKDAIDYRPHNRNQKARQRIARLENLVTELRDKAESSNQSLNDAIQPDNASSHFEPTTSGTSPSVRMGKLSLADNQAVYTGSSHWATILEDIQQLRDELADDGSDIVSEGSSPFASGLTQQSPAPRISLLANVSCLPVDQILALVPPRKIVDRYIFQYFNTFDSIILHRGKFLAEYVNFWVNPSAVSIIWVGFLFSIMSMAVSLQKKEAGMHGLSASELQTTLDTYRTLTIHCLVAGDYLRSSAHTVETLLLHFAVDQEADADANIGNWVLMGVIIRIAMRMGLHREPSHWPNIRPLQAELRRRAWTALYSIDFFTSTQIGLPRIIKDSQCDTRPPSYLLDSDIGFEHDTLPPERPHSEPSMLAFNIHRHGVIKVAAEIYDTTEAGPPPPATIATLQAKLERAADSLPDWLRLRPIEESIADSPATILNRMMLDIITQKAIYLLHRHSFVRGSAGEESVRSSEICIKAALSILEHQRRMNEETQPGGLMYNIRWRVAAPLRSEFMQATMMLCFALSRYDAGRDLHRRSDILQALIVAKDIWETRSDESLEAQRAVKAISIMLEQDRKSSISVSSPSTTFNLSSRPSAENHFGGFDNTFGQTMALDPSFFSVGDDMTALSKVMDEFMNDTAATGLSSSPFTNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1C3</accession>
    <name>S0E1C3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_13698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429563.1">
        <property type="nucleotide sequence ID" value="XM_023576412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1C3"/>
    <dbReference type="STRING" id="1279085.S0E1C3"/>
    <dbReference type="GeneID" id="35407152"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13698"/>
    <dbReference type="HOGENOM" id="CLU_030273_4_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000009">
        <property type="entry name" value="Hydrophobic dipeptide epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF3">
        <property type="entry name" value="ENOLASE SUPERFAMILY MEMBER DDB_G0284701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00180">
        <property type="entry name" value="muconate_cycloisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="147"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT67482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="371" mass="40436" checksum="CFDFF1A395B444E9" modified="2013-09-18" version="1">MSELRIAKIDVFRVDLPYSGGVYYLSGGREYRSFDATMVRITTNTGIEGWGESIPFGSTYIAAHALGVRAGIAEISPWLIGLDPRRVDRINEVMDSALIGHEHAKTPIDIACWDIFGKSVGMPVCELLGGRTDVGLPIISSIYMDNPENMRKRVAKHRARGYIGHSVKIGGEPGEDARRITASLADMQPGEFFLVDANGGMTVENALRMLRLLPPGLDFVLEAPCATWREIVSLRRRSNVPIHFDELATTDASIIQMIVDDAAEGFGVKISKNGGLTKSRRHRDIALAAGYTMSCQETTGSDIAFAAIVHLGQTIPEKNLRCILECRDMVTVKTADGNFEVRNGRVHAPKDPGLGVTPRLDVLGDPVASYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1E6</accession>
    <name>S0E1E6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_13718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429583.1">
        <property type="nucleotide sequence ID" value="XM_023576434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1E6"/>
    <dbReference type="GeneID" id="35407172"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13718"/>
    <dbReference type="HOGENOM" id="CLU_062051_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="401" mass="46027" checksum="8D9C0896D4DC6E87" modified="2013-09-18" version="1">MEISTQRDCFPLLKLPNEILRMIVEKASERARAPTNSYRNENEAVLPYYDDLISLALVCSRLNATATEALYSCICIYADEYRDTDRRAARLSTCRPVSLLHRTLRENVQLRRYCNRFIFVHRRNRQTGDPVEPEFLSPPLGLGEPHQMSIPWPKTFASIILDCTNWLFNTRVLTISGHAFGTWLPELDITYRLLSCGRMSMSRLECIEILNDISYHRDVLTLYDIQLALSGGFLNLKHLTIRHRVRKPSNPRRSNAPGSLATYNPCSGFSLSSLTLINSADHPDLVRNFVIWLKDLKHFTLRWDSGFRFGSRRDPQWSLALVGDILKPHRDSIKSIKLGMMSQPGLGDFDASDFPNLETLTMHHRDLRGIVISTCQQLQAARLHDVVVTTDDIEEEMFYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1K7</accession>
    <name>S0E1K7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to MAG1-3-methyladenine DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430650.1">
        <property type="nucleotide sequence ID" value="XM_023577603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1K7"/>
    <dbReference type="STRING" id="1279085.S0E1K7"/>
    <dbReference type="GeneID" id="35400837"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07360"/>
    <dbReference type="HOGENOM" id="CLU_000445_72_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="184"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT68570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="361" mass="39593" checksum="B8D68469841D461F" modified="2013-09-18" version="1">MVTTRRSSRISAQPASTKESLEKPRSKVTDRKRKAAAVQDEPEAPSTPPPRKRAQGEPATPAVPPPETPTPAAAGLFAEPTSIIQKPRTAAVTRLANPRLTNATLLSPETSRLVASRDIDNLSPSKAPQAKTTTENILKEACDYLIKVDPRMKSLVESHHCRVFSPEGLAEKIDPFENLSSGIISQQVSGAAAKSIKAKFLTLFEELPGNQFPHPSQVAAKSIDELRTAGLSQRKAEYIKGLAEKFVSGELSAQMLHDASDAEVMEKLIAVRGLGKWSVEMFACFGLKRMDVFSLGDLGVQRGMAAFVGRDIAKLKAKGGGKWKYMSEQDMTELSAKFSPYRSLFMWYMWRVEETDISTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1Q1</accession>
    <name>S0E1Q1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_14512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429663.1">
        <property type="nucleotide sequence ID" value="XM_023576455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1Q1"/>
    <dbReference type="STRING" id="1279085.S0E1Q1"/>
    <dbReference type="GeneID" id="35407893"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14512"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000025">
        <property type="entry name" value="NADP(+)-dependent glycerol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT67582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="329" mass="36955" checksum="1AB5E098CE66CDB0" modified="2013-09-18" version="1">MAVSNKTTFTLNNGVKMPGLGFGTFANEGAKGETYEAVKCALKVGYRHLDCAWFYLNEGEVGQAVRDFLAENKDVKREDIFICTKVWNHLHEPEEVKWSFENSLKNFGLDYIDLFLVHWPIAAEKDEDYKPKIGPDGKYVIKKDLTENPEPTWRAMEEIYASGKARAIGVSNWTVEGLKKLLSFAKVKPAVNQIEIHPFLPNEELVKFCQENDILPSAYSPLGSQNQVPTTGEKVRTNETLNAVAERSGNTLAQVLLAWGLRRGYAVLPKSSTPSRIESNFQVPNLSDEDFEAIQSVAKGRHTRFVNMKDTFGYDVWPEETPENGTSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3F4</accession>
    <name>S0E3F4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430247.1">
        <property type="nucleotide sequence ID" value="XM_023577130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3F4"/>
    <dbReference type="STRING" id="1279085.S0E3F4"/>
    <dbReference type="GeneID" id="35400410"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06933"/>
    <dbReference type="HOGENOM" id="CLU_023254_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="529" mass="60746" checksum="923CA3CF27BBBEBC" modified="2013-09-18" version="1">MLEPFLQPVPVPESLPVRAKPRARKPRQQGPKKFEFVSSDPVGKPAPESRKFIRSHVMRGKNTRKSPPRHPILDVRVDALPRANDDVEELDRPAPLAITRCTDAMWTVGHTHARQDRAWVESPSLMAQLVKPPPDLDLFTFATPLDKDSRYYIYRFLTTIKETMYPAEWCFDPDGEKVCWFRWLLEDPAYLHCICFMVSAFQDLINMQSLLGRGKYETGWGGEFSASTRNRLRHTIKLLQERLQDPAKQVEDATTATIISLAMMADAMEDAQAFEAHSNGLRRIVKMRGGLQGYTHNRQLQIKLCRVDLGWSIRNGCKPEIYDGKPAWEPLLEAFGTVACSFEIQEPSLDFMNVYYTWDWRLQNTFKDLRDFSALANKHSPSSKKLKPEAFQEIMLSIQYRLLQLDFSQDPTPIQEALRIGLLAYESTIFLQIQGTKLKSDSFSRQFRDAIQATPVQGEATANIKLWLLVVGSIIVFDSSEDWLVQSINSLTGRQSWEEVRERVKEVMWIDVIHDVSGRKAFEATQSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3N3</accession>
    <name>S0E3N3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_07034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430342.1">
        <property type="nucleotide sequence ID" value="XM_023577242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3N3"/>
    <dbReference type="STRING" id="1279085.S0E3N3"/>
    <dbReference type="GeneID" id="35400511"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07034"/>
    <dbReference type="HOGENOM" id="CLU_039661_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="7">
        <location>
            <begin position="199"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT68262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="403" mass="46547" checksum="46D7BFE4822F5F1B" modified="2013-09-18" version="1">MFGQVRTNRSTVLMAGTVIFLVAFVSLAYNHLDKWEPPADVATDTETSIIGDTHDEPHHDEPKKTEPEQPEQHGAMSKPDHPSNASTELGDYYFNYIMKARISPADKKYAPYGAFPMELPAEPKWTEMIGEDLCIIDLDNRPFDEPGQIFSPGLMSWDRADETHGLSLGVLNHWLYAKNHGYKYYYVDITDPFEDRRNSWKKPPILSKILKKHKACIFLDSDAVFHHLDLPFEWLMNYWQLHPDTNSLALAYDPHHKNNMDKFDKVYLNTGFIVLQNNEKTFEILKEWEDCPNEGGKHPDCVEFRKNRPGKPTDQGGFGTYIRYDYPKDIKDLPCTEANGFPESRSGCDGKFIKHLWTGKKDHIKVVIGQQVPGALLEMFHKQFMDEKPKFFISERDLMAQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3R3</accession>
    <name>S0E3R3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to TRI7-trichothecene biosynthesis gene cluster</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_05356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431549.1">
        <property type="nucleotide sequence ID" value="XM_023578557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3R3"/>
    <dbReference type="STRING" id="1279085.S0E3R3"/>
    <dbReference type="GeneID" id="35398835"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05356"/>
    <dbReference type="HOGENOM" id="CLU_032731_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="251"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT69469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="409" mass="46120" checksum="9623B2344F53880C" modified="2013-09-18" version="1">MSFLISHPTPGLSLGSFTAAHFLCTATLGFTAKDQAWIRRVASILVFIFTFIGDRTASAVSDNASIRCLLVTFSWVQAFNGNSLLCLSKAEYKTLNQERHQNTAPKSVFVGSGASGNGSFFSRLKWAIAMQWNLRRIKTYRPARNTPPFSSKDPSYIPSRGRFLLNRIAVILASIAYMAIIGLQPQPTREDLSGDRIIFFSRLNEVTLYELLQRAISTVTWLSGIGTTSEICYNVIAVVLVGLGLSEPVMWPSWFGSFTEAYSVRRWWSISWHQTWRCFLTDHADWVVYDILHLPKTSLITRHTKNLVVFYISGLIHLAPDLTIGMPLKESSAIMFFTFQAVGIMIEDLVQSLNNKIGLVKSSIMARCIGYVWLAAWLVWTIPWWSFICTMHMKAGQDDLISLAKRNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3Z9</accession>
    <name>S0E3Z9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429529.1">
        <property type="nucleotide sequence ID" value="XM_023576369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3Z9"/>
    <dbReference type="STRING" id="1279085.S0E3Z9"/>
    <dbReference type="GeneID" id="35407113"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13659"/>
    <dbReference type="HOGENOM" id="CLU_068979_5_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="193" mass="20953" checksum="278AB23B5684E91B" modified="2013-09-18" version="1">MSGPVSALFVIDIQKDLASDDKTEIPHAERIRDAGEQILEVARGIAADPKPIIVFVQHEESPESGPLVTGSKPWELVFENDPNNTRELLVSKNQRDTFKSNPDLAGLLRSKGIQHIVAFGIQSECCVLETCKGALEAGLRVTLLQGAHSTYDTENKQALQIEQDVENELKALGASVTPWQTAIGQWANTGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0E491</accession>
    <name>S0E491_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_05595</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431769.1">
        <property type="nucleotide sequence ID" value="XM_023578823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E491"/>
    <dbReference type="STRING" id="1279085.S0E491"/>
    <dbReference type="GeneID" id="35399074"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05595"/>
    <dbReference type="HOGENOM" id="CLU_039068_5_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000121">
        <property type="entry name" value="Sterol 24-C-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 12 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 12 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="15">
        <location>
            <begin position="85"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT69689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="382" mass="42690" checksum="5D3FAF6DD6637CA3" modified="2013-09-18" version="1">MVASSTASNLEREDHQRDADFNKAMHGSSAQARGGVAAMFRKGGSAKQAAVDEYFKHWDNKRAEDETPEERAARTAEYATLTRHYYNLATDLYEYGWGQSFHFCRFSQGEPFYQAIARHEHYLAHQIGIKEGMKVLDVGCGVGGPAREIAKFTGAHITGLNNNDYQIERATHYAFKEGLSDQLKFVKGDFMQMSFPDNSFDAVYAIEATCHAPTLKGIYSEIFRVLKPGGVFGVYEWLMTDEYDNDNLRHREIRLGIEQGDGISNMCKVSEGLDAIKDSGFEMLHHEDLAMRPDALPWYWPLAGELRYIQSVGDIFTIVRMTTWGRTIAHGLAGLLETFKLAPAGTKKTADSLALAADCLVAGGRDHLFTPMYLMVARKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E539</accession>
    <name>S0E539_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_05924</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432073.1">
        <property type="nucleotide sequence ID" value="XM_023579190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E539"/>
    <dbReference type="STRING" id="1279085.S0E539"/>
    <dbReference type="GeneID" id="35399402"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05924"/>
    <dbReference type="HOGENOM" id="CLU_085752_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="95"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT69994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="160" mass="16388" checksum="D05BEC9FF8D070F6" modified="2013-09-18" version="1">MAESELAPKFAPFIGMAGIAAAMVFGCIGAAYGTAKSGIGIAGVGTFRPDLIMKCLIPVVMSGIIAVYSLVISVLIAEDLDPGKNYSLFSGFLHLGCGIAVGMTGLAAGYCIGVVGDTGVRAYMEQSRIFVGMVLILIFGEVLGLYGLIVALLLNSKSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0E549</accession>
    <name>S0E549_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_07649</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430912.1">
        <property type="nucleotide sequence ID" value="XM_023577925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E549"/>
    <dbReference type="STRING" id="1279085.S0E549"/>
    <dbReference type="GeneID" id="35401126"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07649"/>
    <dbReference type="HOGENOM" id="CLU_003041_17_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033677">
        <property type="term" value="F:DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="71"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="259"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="350"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="581"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT68832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="614" mass="68996" checksum="88B5350943330DCC" modified="2013-09-18" version="1">MGYLSKRKRDQTEEVVTDDKPAATEVEKPTKLSQKQEDETSFVDLGLDPRLLQAIAQQKFAKPTLVQRKAIPLALNGQDVLAKADCGSGKTAAYVLPLLSSILKRKATDSTAFTTALILVPTRELADQVFKAIEQFASFCAKDISTVKLTDKVSNAVQRALLSNSPDIVISTPATAWHNVNSSALSIDKLTHLILDEADLVLSYGYSEDLENLSRSVPKGVQVMMMSATLTDEVDTLKGIFRRDPTLLDLKEKEAEGEGITQFVAKCGEDEKFLLAYVIFKLKLIKGKCIIFVSDIDRCYRLKLFFEQFGIRSCILNSELPLNSRVHVVEEFNKHVYDIIIAADEKNEMMGDDEEPVGGETEDAEKQGDGDDAETEAKRPKKKAKKSKGADKEYGVSRGVDFKKVSAVINFDLPTTASAYTHRIGRTARAGQTGMALSFVVPKDLYRKHMPTSTPTSENDEKVMAKIIRQQAKRGKEVKPYNFNMKQVDPFRYRMNDALRAVTKVSIREARTRELRQELLKSEKLKRYFEENPTELAHLRHDGELRTARQQAHLKHIPEYLLPKDGKQALTNDIGFVGLRKDRKGHKGKKGRGFKVGSRKRDPLKTFKARRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E592</accession>
    <name>S0E592_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to V.vinifera dihydroflavonol 4-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432015.1">
        <property type="nucleotide sequence ID" value="XM_023579121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E592"/>
    <dbReference type="STRING" id="1279085.S0E592"/>
    <dbReference type="GeneID" id="35399339"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05861"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="341" mass="36443" checksum="59EC983CFCAFB563" modified="2013-09-18" version="1">MSSKPIVLVTGANGYIAGPVIEAFLKAGYAVRGTVRSRSSADPLVRALSAYEEDLEIVEVPDIVASGAFDSAVKGVHAIAHLAAGVSLSFTDPDPVLEVAIQGTLGVLESAITESSVKSVVLMSSVASIINGSKEAPARFTEADWNDEALAAVKKLGKESPSFLIYAASKVASEKAFWKFRDDRSPSFTMTALNPVFVMGPQPGLESISKIGGTTAFIWQILSGQEIPKPLTPNPGYVDVRDIARVAVFSVDHPDKANGERFLLASGLVPPQAAADVLRKAYPERQDIIKVGTPGQGYFPDYRFPEERVLDASKAVKVTGQSFYHVEQTITDTAKSLEKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5I9</accession>
    <name>S0E5I9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_14634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429944.1">
        <property type="nucleotide sequence ID" value="XM_023576589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5I9"/>
    <dbReference type="STRING" id="1279085.S0E5I9"/>
    <dbReference type="GeneID" id="35408014"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14634"/>
    <dbReference type="HOGENOM" id="CLU_445521_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="2EXR" evidence="4">
        <location>
            <begin position="380"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="613" mass="70303" checksum="95E5A3F0233FE632" modified="2013-09-18" version="1">MESRLTYNDASSSEEVIVRRHPPRVIFVRHIRTNWLKYATGLLLILSISQLIYITRLGTGMVRIPNDPYDLRFGHLSHDSPEIWDDNHQSFLRSARPVPIHSHNDYTRHIPLFEALGSGCISIEADVHLRHGNLFVAHSRLSVNPHRTLQGLYLKPLQRMLEARNAGVKIDDWQGFFEMAPKQTVTLLVDLKTAGPETFDALNAQLQPLRDLGYLTYWNGTERIIRPLTVVGTGNTPFESVLAMNSTHRDIFWDAKLERLVSMDDDFSTNPPTYKFNRSNSYFASTRFENAILYRSNFQRVLDTPPSRELDMALTQIEQAKARGLLARYWDTPSKPPNVRDIAWRVLIDNGIGILNMDDMGLSHSEIFNRGAKVAGPSSFTLFPSLPAEIRVSIWTWALRHQRIIKIFLRSHAGFCGNRNRNGIHFPPLEPGRSDPTYYPVVDGHRLLSKLLRVNTESKEVALSFHRVRLPCWFADREDNYGLWTSGTTYINPEYDFLQIQEDTMATVDFVCDLKTKHDPRNVGIRNIALCSNQLGGRPSGLHAMRPSEIESSKMRIFKEIISGLDEVWLISIQESVRQMIGGENEWPTIRKTFFERSVPIHATPHSFDTYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5R3</accession>
    <name>S0E5R3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein fta4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431107.1">
        <property type="nucleotide sequence ID" value="XM_023578272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5R3"/>
    <dbReference type="STRING" id="1279085.S0E5R3"/>
    <dbReference type="GeneID" id="35401438"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07961"/>
    <dbReference type="HOGENOM" id="CLU_058478_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
        <property type="entry name" value="FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28368" checksum="4E62241569931507" modified="2013-09-18" version="1">MSSRPAAPTIPSLKQSFITSQTTLLSQPIAPSPSWQETNDASDEAIPERVVQEVLYNLNHTIQQHCRRVYPPQASRSIAEQINDVYTKDAERKVGGAADTEGGIGRELDLTEDKSIEALPTSWHLEKDINDHPMETKRYADAVQRLTELNDQRKQLRDKVARLKRLQTIVEPLQTDENGAGIQENLLTRNGPVEKELERMRILLARVGGRVLSLPEEAPNGEAKEVSLTEMGAQRRKRRVDQFLADDKVFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6P9</accession>
    <name>S0E6P9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to Free methionine-R-sulfoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431502.1">
        <property type="nucleotide sequence ID" value="XM_023577718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6P9"/>
    <dbReference type="STRING" id="1279085.S0E6P9"/>
    <dbReference type="GeneID" id="35400939"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07462"/>
    <dbReference type="HOGENOM" id="CLU_077738_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000048">
        <property type="entry name" value="Free methionine-R-sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="65"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="182" mass="19839" checksum="078F0A9293CEB974" modified="2013-09-18" version="1">MVHADASNFAHGITKEDAYEQVLWQAEGLITDQRNWFNSNLSNAASLLWHAYKSLESPSKDVNWAGFYVLDKSSQDPQLILGPFQGKVACQTIKFGKGVCGAAAATQETQLVRDVEEFPGHIACDGDSKSEIVVPIVVTQDDGSKKLVAIVDIDCAELNGFDEVDKAHLEQLAALLAKSCDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6S7</accession>
    <name>S0E6S7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_05334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431527.1">
        <property type="nucleotide sequence ID" value="XM_023578533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6S7"/>
    <dbReference type="STRING" id="1279085.S0E6S7"/>
    <dbReference type="GeneID" id="35398813"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05334"/>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="41"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT69447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="359" mass="40722" checksum="1419DB0C6581C321" modified="2013-09-18" version="1">MSPSQIETTSSHGNGKATHDTKLIKEPLKLIGLLDKYESFSVTPVIGTEFTDANVAEWLKADNSDDLIRELAITISRRGVVFFRAQKDLTNELQMELADRLGRLTGKPESSTLHVHPLQNFNPDEEKHINTITTDQATNPAEDLWKNRPADIRNSWHTDAGYEPNPPDYSILKVVKMPPTGGDTMWASSCEIYDKISPHYRKFLEGLTASFSQRRLPRVAKEKGFELYTQPRGSPNNVGDSLTTTHPVVRTNPVTGWKSLFAVGNHCESINELTPDESKRLLDWFLQMIVEEHDCQLRHRWQNPYDLAIWDNRTVYHTAIFDYAGLGPRTGHRAVGIGEKPYFDVKSKTRREALAMEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6S8</accession>
    <name>S0E6S8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin depend monooxygenase that catalyses the oxidation of rubrofusarin to 9-hydroxyrubrofusarin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_06500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432600.1">
        <property type="nucleotide sequence ID" value="XM_023579832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6S8"/>
    <dbReference type="STRING" id="1279085.S0E6S8"/>
    <dbReference type="GeneID" id="35399977"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06500"/>
    <dbReference type="HOGENOM" id="CLU_006909_8_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT70521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="531" mass="59510" checksum="D1195C7188462173" modified="2013-09-18" version="1">MDKQPQKVAVIGLGIAGLVAVKNLLEVGFDVTGFERSEYVGGLWHYTEQDKTSVLPSTIINISKERAAFTDFPYPDSTPSHCPSAKVQEYIESYVDHFNFRDKLRLGVSVEKVRRDDAGNRWVVDIKGSEPEYFDKVIMATGGNNRPHIPKVEGMEQFEGDVLHSRAFKRPELYKGKRVIVVGVSNTGADTAAALCGHAEKIWLSRSHGVIVIPRKRDGIPFDHTLTARTMAFMGTFEITFPSLYEIIFNAICKKMQDNAFKIRPEWGLSPAISVLHALPVISDNLIPLLESGDITSVPKIKRVTGPREIELTDGTRLGVDTIIWCTGYEADFSLMDPSIDPTRNTTPKWAEAIGSRGKPLPRLYQNVFSLDYPDSLAFMGNLLVATSAFPISDICTMAIAQIWKGNSPLPSIDEMNRATDQHHETICKLANRGSVVPGWLRQSDWLAWADKAAGSQVYEHLGWGLKGWKLWWNDRALYRMLMDGVFTPFVWRVFDGEGKRKKWDGAREAIEKVNVELAAAKARNKNKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6X8</accession>
    <name>S0E6X8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_07057</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430363.1">
        <property type="nucleotide sequence ID" value="XM_023577267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6X8"/>
    <dbReference type="STRING" id="1279085.S0E6X8"/>
    <dbReference type="GeneID" id="35400534"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07057"/>
    <dbReference type="HOGENOM" id="CLU_001832_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="243"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="425"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT68283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="876" mass="99713" checksum="840A544C7FB31ED4" modified="2013-09-18" version="1">MSAKRYAFLPMEDEAGEEKGESSKKPSKKRKTEDTAARNKAALPDIRERSRQEYLKKREAERLALLRKQVAEETDELRSGVRLSEKEKAEFAKNREILRLAEERLNIDDHRDGYYMPEDYITEKGRLDRKKKEEVLYKKHVERDQFGREKFVTEHEEWEREQTTKVKAQIQRAERENDDYDFLMDESQYIQWKSDARRTDDGRTLTKEQQALNARIDEAEKKALSIQETRKSLPIYQYRDEFLAALEKYQVLVIVGETGSGKTTQLPQYLHEAGYTKNGMKVGCTQPRRVAAMSVAARVADEVGVKIGREVGYTIRFEDCTSDKTILKYMTDGMLLREIMTDPELSSYSALMIDEAHERTVHTDILLALLKDLSRARPDLKLLISSATMNAERFAQYFDDAPIFNIPGRRYPVDIYYTPAPEANYLTAAIVTTFQIHTTQPKGDILIFLTGQDEIEAAELELTQTAKKLGNRIKELVICPIYANLPSDLQAKIFEPTPEGARKVVLATNIAETSLTIDGIVYVIDPGFVKENVYNPATRSSNLVVVPCSRASANQRSGRAGRVGPGKCFRLYTKFAYMNEMDESTTPEIQRTNLNGVVLQLKSLGINELLDFDFMDPPSKDSLIGALNQLYALQALNRHGALTKVGRQMAEFPTDPLLAKAVLAASKEGCVEEVLSIVSMLGEASTLFFRPKDKKIEADSARNRFTIKDGGDHVTLLNIWTQWVDSGFSPIWAKENFLQQRTLTRARDVRDQLEKLCERVEVALSSCGASNLTPIKRAITSGFFVNAARLQKSGDGYRMVKTNTSMWIHPSSVMMSVDPPPKMVIYFELVQTTKDYMRSVMPIEPKWLGELAPHFYKKDDMEDLVAKKMPKQRTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E746</accession>
    <name>S0E746_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431627.1">
        <property type="nucleotide sequence ID" value="XM_023578653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E746"/>
    <dbReference type="GeneID" id="35398921"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05442"/>
    <dbReference type="HOGENOM" id="CLU_1555384_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="172" mass="19971" checksum="BDA2DFFD929DC9C1" modified="2013-09-18" version="1">MQALPRTIAVIHTPYWNASEQEDELQNVSVPTIIYFPRSDKKGYATNDSSRRPNRESQSKVHHSYNKQLPSHSEANRPEQSPKSVFSSPSITCNFNMTDFERFLLSDTGKEAAQNKYSYYTVPQSTPERISSPKKRRRVDGLKMAERELREYERWVFGTWENIFSGSYSYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8G9</accession>
    <name>S0E8G9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433260.1">
        <property type="nucleotide sequence ID" value="XM_023580491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8G9"/>
    <dbReference type="STRING" id="1279085.S0E8G9"/>
    <dbReference type="GeneID" id="35402246"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08770"/>
    <dbReference type="HOGENOM" id="CLU_013432_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1030" mass="112013" checksum="D67C01C6BB70D193" modified="2013-09-18" version="1">MAVPWNSMGMPPSDADHDKIVVGPYDDSRYTASSSGLSYIRHPSSQPTNSTARLIPQPLLSPPIARVSPGPRSPSSPRSPASFQSLNSPSSPGFPLSPFYPPSPGPLQRGQFPNSPTSDGFSSPRMSGATAATDPRLSTKASNMMETVLETPYFDTPPNTPGSWGDASRGTDNLDATEVPLNNGWRPWWLRRRVISIFIGASIMLAVIGEVVMWWLSNNEVDSSLKGLWTFGPVVVVSIMAILWARVEAQALLYMPWIVLDRRPTTVDETRRKQAHRTILLDYPSLGSLQALTKAFRNRHHLVVASIVIKILLRAQIVLSTAVFHAEIYVDSTTRLRARLGILHAMVGVFLIISGVLLPMLYHAPSPRGIAPRDPTSPAGTAALLTSSQQFLSRLSGTGHADMNAVAGRLAGSWYTTELTQPGRRPEEMFQLRQHGGGNGALGMNPSNRPEEATGTYQPWTQVTRTKLISIATSVALIVGICVIYNLKGNENGLEVDDSIFVVWTCLPTIIFAALAVFWSRIDIDNRRLAPFLKLTNSKCRFQESLGLTYMNEFGLHTAGKAMKNQDWAVFLAKCTSMLGWLMPIFTAGLFAVSQMAQSANLELRPESQFVSTTKSLSTAIDSDTIENVLLRETPKYPRWTWEDVALPAVSLVDHPSEWPLPNTELVAKVPSLRGKLTCETISLYGGEGVDWQCVPLGGSTKQPICGSDQSRTALVASSCSQLSSKYSLKYIWGSCSDDGMISVMMCNQSVVEVDVLTTFRTEDLSINSNAIPIVNASSEAPSGVTADITSVYEALGSVGADNKTMNGLDAFFRTLVLSRLQTTLERIAMPERQNSVSQAIRQLHGILAAQAINSDLIRRPLSSKLRARDDSPTDIPASVDYVLPRLMQGSVQSFVLIGLLGFTLAFGLLSLRTASRGTLSKSPGSIAAQASLLADSTLWWRLPDGAEWMEDDDLARCLRRRTFHLGWSKGAAGTRGYGIGIVQDEGKVARPPMVSQTSADKSAGLVPGRYISMAPGVYSYGDVATYEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8N3</accession>
    <name>S0E8N3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430918.1">
        <property type="nucleotide sequence ID" value="XM_023577933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8N3"/>
    <dbReference type="STRING" id="1279085.S0E8N3"/>
    <dbReference type="GeneID" id="35401133"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07656"/>
    <dbReference type="HOGENOM" id="CLU_067850_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="196" mass="22349" checksum="7C8649ED8B6F8AD4" modified="2013-09-18" version="1">MTEKQETNLSPTDSNFTFDESVAAWNVNHREWLKTHDKTWDSLATGALVFDTSNRILLLQRAPDDSMPNKWEIPGGACDDEDETVLYGCARELWEEAGLKLRHVRRVIPDGPNGKPGAVFTNRTGKRFFCKFSFEVDVEDTAEVKLDPKEHQDYVWATEDEVKGQKMGDREIPLTNGLMVRLIEKGFAMKRDDKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8T2</accession>
    <name>S0E8T2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="15">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PIF1</name>
        <name evidence="18" type="ORF">FFUJ_08657</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="15"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="S0E8T2"/>
    <dbReference type="STRING" id="1279085.S0E8T2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08657"/>
    <dbReference type="HOGENOM" id="CLU_001613_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="RHEA"/>
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        <property type="term" value="F:single-stranded DNA binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:DNA recombination"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:telomere maintenance"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="322"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="15">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="133"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="330"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
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            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT71284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="821" mass="90690" checksum="E3B29A6DD3FC88A9" modified="2013-09-18" version="1">MLQRANSQYEANGPPPQQRGQPKSQSFLPSSSPSTHNADIRQQLKKSNAPAVSARTMPPFSRPLQNRPSNMNQLSNNSRPPNGVGGGSLASLCGGSNSFGGQADVVDLTGPEAHAKAQAAVFFTEDDFCDDDDLDLDFQAPSALPPLPANTPSKRITKENMPPPPPTSTQTDKAIPWSSSPPSHFLPPSRNTSVTSTMANISMKRDSSGDRDDFDVPVPKKAKKRVLPQSFKQEEPEDESDFHSQVAQTPNNKRKDFLNPTASAVKEQKKQFRTQRQQEQPTASTDLSMDEIKEVSTSHSKGNFAISLSEEQRHVLDLVVNKNQSVFFTGAAGTGKSVLMRAIITELKKKYAKDPERVAVTASTGLAACNIGGITLHSFSGIGLGKEDAQALVKKIRRNPKAKNRWLRTKCLVIDEISMVDGDLFDKLSTIGRTIRNNGRPWGGIQLIITGDFFQLPPVPEQGAKRETKFAFDASTWTTSIDHTIGLTQVFRQRDPVFANMLNEMRLGRITEDTVRAFKKLERPLNFNDGLGTAELFSTRNEVEMSNERRLRELPGTIRRYEAQDTGKEDIRDKLLMNMMAPKSIDLKINAQVMLIKNLDESLVNGSLGKVIGFSDEKTFDMEPIDEFDEEERMAKARKKLLNTFKRESDSSSGGTKFPVVQFMATDGTSRVILCQPEEWKVELPNGELQAKRTQLPLILAWSLSIHKAQGQTLERVKVNLGRVFEKGQAYVALSRATTQDGLQVLGFQKSKVMAHPRVIDFYNKLYSAEEALGKPKAQSITSLVSNRIGAAPSKAPAPSKSARQVIDLDDEEEAMASMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8X5</accession>
    <name>S0E8X5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_06189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432316.1">
        <property type="nucleotide sequence ID" value="XM_023579487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8X5"/>
    <dbReference type="STRING" id="1279085.S0E8X5"/>
    <dbReference type="GeneID" id="35399666"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06189"/>
    <dbReference type="HOGENOM" id="CLU_072440_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="16"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT70237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="167" mass="18042" checksum="65C6019EBF7A1A8D" modified="2013-09-18" version="1">MSELKAGDNFPEGVWFSYIPPSPETSEFTTCGTPVPFNASQEFKNKKVVLVSIPGAFTPTCSGSHIPSYLEHVDKIKAKGVDQVIVIAVNDPFVMSGWAKANGITDDKILFMSDKDAKFSQTIGWNIGERTGRFAIIVDQGKVVYAARDEEPGSIEKSGALGVLAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9B5</accession>
    <name>S0E9B5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_08684</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433339.1">
        <property type="nucleotide sequence ID" value="XM_023580587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9B5"/>
    <dbReference type="STRING" id="1279085.S0E9B5"/>
    <dbReference type="GeneID" id="35402160"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08684"/>
    <dbReference type="HOGENOM" id="CLU_008451_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="686"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT71260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="817" mass="91903" checksum="CB2E4D3FF108B470" modified="2013-09-18" version="1">MADIDTSKLTSSAQIFSPNNTLPQIRAIHKSLHVAIEEKSTRLRTQVGSSYRDLLGTADTIVHMRDDNDVVQELLGKMGGRCGRAVISAKATGLANFVAKENKSAPSIAARLRLLDACVLVVGRILKGSGGLGDNAKKGDRLVLSTKVLVLSRLLIKSLSDDATDTSSRQDMETARASVSKLRRRLLRNVEKVFERAGDETEREDVQKALCAYSLATSSGARDVLRHFLHVRAEAMGLAFEVEENNRKRSADDVVQSLRLYSRTLLDVQALVPGRLSLALSGLKSHPLLADSGLKQLEGLRLDLYERWCDEEIQYFTPFVRHDDLDGSQAREMLAAWSEKGSEVLLDGLKKTLDTMSEFKSIMELRTSVLELWIRDGGKARGIDPSEMQDSLREAINSRMLEVLDIKVSKLRLVGSEISAALGRWKDGITDEHVSIWNEDGYDEALVGGAAPFVQEVVSRFYGRNDAVSKAAHSYKSWYHVIDDVKEVVEQLRRQRWDNDYDEIEDEETIEARQKLLSKEDPQMLQERLDATLDKYFKELEDQIQSLWDERAESLRNGKVAMYFLRVLRDIRNQIPDRPSIKNFGLKAVPSMHEKVALAVSRSTLEEFSKQGLSQRLVVGRPLWDGEPALPNQPSPEVFQFLRSLSLSMSDEGADLWTKAAVSVLKKHLAKQLCKMWEAAVVEHSVDDREDVKDEKSGEVDAKEDTKEGDTEDENAEETDEKKASAEEELPKPEDDTKEKKPGLSAEQKTDVFTQWLFDIALLRRCIGNTELTGSSFQNLEDNVYRHSKLDEAAKHRISKSSNDFWQRVSLLFGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9V7</accession>
    <name>S0E9V7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433775.1">
        <property type="nucleotide sequence ID" value="XM_023581119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9V7"/>
    <dbReference type="GeneID" id="35401683"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08207"/>
    <dbReference type="HOGENOM" id="CLU_169797_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="76" mass="8329" checksum="E35EE8786B19D559" modified="2013-09-18" version="1">MDFIKNAVSGGSKSGDASKTGDASKNQEDYVDKGVDFLNKKGGFNISRDNQEKATDFARSQYEKQTGNKVDPKYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA61</accession>
    <name>S0EA61_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432706.1">
        <property type="nucleotide sequence ID" value="XM_023579960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA61"/>
    <dbReference type="STRING" id="1279085.S0EA61"/>
    <dbReference type="GeneID" id="35400092"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06615"/>
    <dbReference type="HOGENOM" id="CLU_000288_31_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39548" checksum="BF0B49816D93B548" modified="2013-09-18" version="1">MARSYHNKPSLATTYRTATGRRTVPLTDPQGLRLRFPIDIGGTSVFSRDADSVIFIPHCRFWTDGPEDDDPDADWREEPGGFVCFKTSYAYNMIGQEHPRIVPVIGQDAWTGLPILQKPTYGSLWNFLGNYESQIYATQEDSAPPTTRMKPEYRPLAYQWSLQLLSALSLIHSHGIAYGEINGENCWITAGSLSISLAGFVGSEFHDPSTRYNLPGWFFTDTDYAPDKLPLDRAVKVPTLKTDMFYFGSLVYEFMTGRMPGLEDSRETRRLIVEEDWMADLEDRFMGKIVRKCWRFEYEDVEELQGEVQAFIEACGWSIRGDELEGFDAHSIHRELEANFVPEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAL8</accession>
    <name>S0EAL8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to UDP-N-acetyl-D-mannosamine 6-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_08218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433764.1">
        <property type="nucleotide sequence ID" value="XM_023581106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAL8"/>
    <dbReference type="STRING" id="1279085.S0EAL8"/>
    <dbReference type="GeneID" id="35401694"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08218"/>
    <dbReference type="HOGENOM" id="CLU_023810_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491:SF2">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase N-terminal" evidence="5">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase dimerisation" evidence="4">
        <location>
            <begin position="202"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT71685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="413" mass="45815" checksum="5E1AC98B4CCA4958" modified="2013-09-18" version="1">MPHKIEQPVLEDNQVLAAKQDILVAVIGIGFVGTGLVSTFSTAYPVLGFDVSQKRIAEVAREFCTRPNTRFTTQESDLGQATHFLISVPTLLLPDKSVDLSYIKSALDVIWRWAKPQSTIVVESSVAVGMTRKLLGPLALSNDYFVGMSPERIDPGRTEPPMHSIPKVVSGLDDISPGSLSSITKLYQRVFDQVIPVSSPEVAEMTKLYENCQRMMGIAFANEMADACISHNINPFEVCRAASTKPFGYMPFSPSLGVGGHCIPVNPYYLLLNNDFPLLRQAAERMHQRPRRIALRILNELYADEHQSDSGILVPKRVLIVGIGFKAGQSHLVNSPGLALAEEFQRLSQVDVMFADSLVHQSQVPHIEKLPEKSWKKDCLEDFDVIVVAFRQVAMELGVLKNIRGVKVQMWCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAP1</accession>
    <name>S0EAP1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable UGA2-succinate semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432906.1">
        <property type="nucleotide sequence ID" value="XM_023580065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAP1"/>
    <dbReference type="STRING" id="1279085.S0EAP1"/>
    <dbReference type="GeneID" id="35402629"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09155"/>
    <dbReference type="HOGENOM" id="CLU_994166_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="280" mass="30183" checksum="74424B51A5B1C30D" modified="2013-09-18" version="1">MSLCDNGILVNYTYLGSKNCCTKRRLVTTSIPALIERALFFSIEGGGRFDLIKLPKSRKGWASYSATKTHLVSQYFRCPSLYARDFSLLHAAVMSPGFLAVKGIGFNVAGKAERIHGSIRASSNPKRRVLAAKQPIRVTVALVSCNFLIAIVMRKASAAFAVGCYMTVKPSPETPLFCLALAYLASKAGFPAGTFNVLTTSLENTPGISVVLCNHPLNAKVRLTGSTRKSKIVAGLYAQGLKKCTLELGGNCPVIVFDDADIGQAISQIMALKWRNVGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAW4</accession>
    <name>S0EAW4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433879.1">
        <property type="nucleotide sequence ID" value="XM_023581244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAW4"/>
    <dbReference type="STRING" id="1279085.S0EAW4"/>
    <dbReference type="GeneID" id="35401571"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08094"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="347" mass="38375" checksum="436FF08491098303" modified="2013-09-18" version="1">MSSKTSLVFVPGAWHKPSCYSKVMEQLQNQHHLTCIPVTLPTTMDDPMASFKDDVDAVRGAIRQETEKGRDVIVITHSYGGTVGNSAVKGFSRSPELSTSGQSSVSPSTSRERNAETGHVVGIIPIATGFCFTGLTFMGHFLNITPPFFRVNKKTGYADLTVRPQKFFYHDLPPAEADHATSMLTTQSLKALFEGREYSYSGWLDVPVWFIGTVQDQGLPILVQRAQIGMVRVLGGRVVYTELKTSHSPFLSQPKQVVQIVLQAFESFTGTRADDTPETLELANRPFIPLKGQELISVRGDKDGLDTLGRCKSVQRENLQSMFRYYALLSQGLHVQFGALLDILDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB19</accession>
    <name>S0EB19_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable conserved mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_13889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434189.1">
        <property type="nucleotide sequence ID" value="XM_023581500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB19"/>
    <dbReference type="STRING" id="1279085.S0EB19"/>
    <dbReference type="GeneID" id="35407343"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13889"/>
    <dbReference type="HOGENOM" id="CLU_069193_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="291" mass="31460" checksum="8993CFCDAAA6A880" modified="2013-09-18" version="1">MSNEKQADMSKLSTSLKALINAPFAKPGPRPAPKQVQELYEAIANDAAIRNLGPKSWLTVSAAATFTLNSPDSLPVLHRVASAKDPNSAVQNAEFIREVGLKCISFNGIPRTINSLNAFHASLPEEVTSKLSTKPSRQPTSQNIDEALARGRGLWDSIYRPYEDKLFEKLALAHPDLPVYILSSHYSALLSDPPASQRDTLASLGRVHSSMIAISCLRAQTGVGPQVLSHVFGLRKALEDGTYKNDQDGESEEAVQYLASDEGGHWILNTVDKIVEAIGGSSFAPGRDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBL2</accession>
    <name>S0EBL2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433231.1">
        <property type="nucleotide sequence ID" value="XM_023580458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBL2"/>
    <dbReference type="STRING" id="1279085.S0EBL2"/>
    <dbReference type="GeneID" id="35402276"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08800"/>
    <dbReference type="HOGENOM" id="CLU_026242_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="458" mass="50283" checksum="ECEAC59FC7A322D3" modified="2013-09-18" version="1">MSGGFNREGVHPGLFRPPISPSSSTSYGYASPYSTATPDGQATKRKRPCHDISRSQEFRFQDDSDRNGYFGTPVAQMRNEEMRYQLAGQLDTPSSGPFHSGILDESMYSDTDYRKALGSKRTHDDIDHGAGPTQLFNLPPQPIQSQGWGSFAFSTIGGVVGRVWEFCKTGSFRGFQAGGGKAFTMNSGRVKELDQTLFERQHLPGRFPPSQEDYFNQRQSDNAEQGGNSGASTPTAPHPKRRHTDTKDELGRNWVMVSDEKPAEPEPKPEPPLRRPSYRPSPRSRNSGPSMTTGRRISAAPSARFSTASTPGQRRSTTNRPTSRLSHAAASPSPRPASTASFASLAPLASPRIESPSRIPQPTRSTRRSTTISSPITKPSSHRRSHSNASVASGRTSAEASPRLTAEAKHLAARRKMEERDADVRINAFNKQLQDMIRQGREALGTTIEVEGNWEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBN5</accession>
    <name>S0EBN5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable FZR protein (Fizzy-related protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_12222</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434439.1">
        <property type="nucleotide sequence ID" value="XM_023581802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBN5"/>
    <dbReference type="STRING" id="1279085.S0EBN5"/>
    <dbReference type="GeneID" id="35405678"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12222"/>
    <dbReference type="HOGENOM" id="CLU_014831_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="10">
        <location>
            <begin position="295"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="339"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="422"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="552"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT72361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="609" mass="67060" checksum="D108C80805E663BE" modified="2013-09-18" version="1">MAALPEAAGMAALNHQSAKRAIDESKSHTATPRSSTPPRSDRARLEPRHSHDNAPNRALRSNARKSEGARASPFDIDAVDSALLREFQRPQRESTPGASPHRKRQRINGDRFIPTRSGQDLQASFSLLHEDGSPATPSKQKKRTPHGELHFQKTEEANRTFSHLLRAELFESSVPQAATPTLTPTQTLPTSSHIPTNDGTRAHTPPANATAPSLPSSLTPSTPHKNLFSYMSPRHHNQVAGHPTPSKTPQSRHGPNLDTRSEIYSLSPVRFGSQQMLLSPRRQPRAVSKVPYKVLDAPELADDFYLNLVDWGSANILGVGLGSSVYMWNAQTSKVNKLCTLDDDTVTSVSWIQKGTHLAIGTGKGLVQIWDAEKARRLRTMTGHTARVGSLAWNTHILTSGSRDRLIYHRDVRAPDQWLRKLVGHKQEVCGLKWNCEDGQLASGGNDNKLMVWDKLSETPLWKFSDHTAAVKAISWSPHQRGLLASGGGTADRRIIFHDTVKGSVINEIDTGSQVCNIAWSKNSNEIVSTHGYSQNQIVVWKYPSMTQVASLTGHTYRVLYLAMSPDGRTIVTGAGDETLRFWSTFGRRPGTREDGDNGGRLADLAVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC87</accession>
    <name>S0EC87_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_12424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434624.1">
        <property type="nucleotide sequence ID" value="XM_023582029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC87"/>
    <dbReference type="STRING" id="1279085.S0EC87"/>
    <dbReference type="GeneID" id="35405880"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12424"/>
    <dbReference type="HOGENOM" id="CLU_043560_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE/SOLUTE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567:SF1">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="177"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT72546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39686" checksum="A84268E76E583D50" modified="2013-09-18" version="1">MTTQVDPETLARSTEQTPLLADQPSPEINEVDNEPEAEPTPEKRPRSWYAWRIFWTVLAIVVLAVFVKGWIDSDETEFDLKKALKRALGGGLSGAAAMVLQVLLLMPLRTIMNYQYRHGTSFTVATRTLYTEGGVRRYYQGIAPALFQGPIARFGDTAANAGILALLQSNPYLKNLPSPVKTIFASLCAAAFRMILTPIDTLKTTLQAQGARGTALLRRRIKSNGIGSLWWGAFATAAATFVGHYPWFATYNYLSEVITEPPRHPLFWWLLRLAFIGFCASIVSDSISNSLRVVKTYRQVNDTKVSYAEAARAVVIQDGVIGLLGRGLKTRILANGLQGILFSILWKLFLDLWEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECL7</accession>
    <name>S0ECL7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434774.1">
        <property type="nucleotide sequence ID" value="XM_023582210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECL7"/>
    <dbReference type="STRING" id="1279085.S0ECL7"/>
    <dbReference type="GeneID" id="35406043"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12587"/>
    <dbReference type="HOGENOM" id="CLU_340108_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029167">
        <property type="entry name" value="Mug117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15474">
        <property type="entry name" value="MU117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485098" evidence="2">
        <location>
            <begin position="22"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="915" mass="96416" checksum="84B7D399568FB375" modified="2013-09-18" version="1">MARRSLLGVIFLGLLATLSQANLLGDAHLFKRYSQVYVMPPVSTHSANDVLSGHRNATRTSIRSLLPASTLGMGYGTSLSSTSLFESTGLETETKTNVYIDHGTSEVLSQTTESISDPVSGDQGISTTSIEVDWTGLLPVTPSTRQSFFKTTLPLTGQDPAATDPATGITPHPNTSYDTSSNRATEPTTTDMLLQITSVANSDTSVALPGNSETSRSGFESKELGTADETTMFPSETSQAFQDSTSRLFTTLPDQTSGIWDSTTTTIQSDDELDSTSPSSEALTVSDGASRALESSQPTMESGTIELESSTTLSGSANSSPPSTTLDKTEPVTKSNTKSLTSEKTPEATNLPIATGSVASSTMTSEDGIVTGTDGTVATYVPEQNKDYISSTGTTTTTDDNGAAIVIFPFGWFWKLQDGRGGGAVVRPPAPTANPVPENEPGDKNEDDGDDEDDSTKEEDRSTVQSTVLSTTPEPTSATTSTYEQTTSEECTAATQPDCTKTISYMTSDGTQIMTEFGNCPTIISCATKTQATETLTLTSEFIWAGVPNTNPAIVIPEDAYTADVDPKIVAALEAQWAEIFDDDDGWNDTETSTVSGSTTVDESTMTGPTDTEAVSTVTSESSTTAHNSSLTSNTEATASFTTASDTYSVTTAPSTLITKTRGTGNTTDMPASTDQEATRTYYPCVIHGGPAVETPYCQCSTTVSGEGYYATTTLVDDQCVAYTEFPSQITAAPETGPITDEPIQQPITTTTDGTVLVWSAYVLDYINIPGITKITQSVGVGEPSTVSTPLPSQTAVDNDGGGQCGTGDGLSKKGLREACDRAIDKYEDDTIYSDYTSRYSRSTKGILVAASVGQAACIAKFQCDDYGIGKKGSDIEEARESAKENDGVDICGHVRLSNSCTIIMDYCTNCKTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECQ1</accession>
    <name>S0ECQ1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_12546</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434737.1">
        <property type="nucleotide sequence ID" value="XM_023582165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECQ1"/>
    <dbReference type="STRING" id="1279085.S0ECQ1"/>
    <dbReference type="GeneID" id="35406002"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12546"/>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_1"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="8"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="239"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT72659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="328" mass="34291" checksum="1ABAC9E660BECABC" modified="2013-09-18" version="1">MSSPRPVISVLGSLNIDLVSYVPHHPLPGETITSSQFNVFPGGKGANQAVACAKLSRTSDLKSPSVDVAMIGAVGADAYGSVLLDSLKSYDVGTSSIIVNKDGGAGSQSGIAMIIVDEPTGQNRIILSPGANNSLQPSHFAEIPGPTPSLLIMQLEIPLETVIQAFKAAKTTGTPVLLNPAPAQVLPAEIYQDLAHLILNETEAALLSNKDESEFENISVVEKAAADFLARGVRNVVITLGGKGAYYASDKGAKGLIPALKVEVVDTTAAGDTFIGAYAVELAGAEQRSEQFDIEKAVRSGIWASSKTVVRRGAQVSIPWKDELESTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECR1</accession>
    <name>S0ECR1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein RXT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432252.1">
        <property type="nucleotide sequence ID" value="XM_023579410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECR1"/>
    <dbReference type="STRING" id="1279085.S0ECR1"/>
    <dbReference type="GeneID" id="35399598"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06121"/>
    <dbReference type="HOGENOM" id="CLU_030828_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039602">
        <property type="entry name" value="Rxt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013904">
        <property type="entry name" value="RXT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08595">
        <property type="entry name" value="RXT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="422" mass="46534" checksum="F59553EA54682335" modified="2013-09-18" version="1">MASQQILFAETIAESDSDSEIESYSNRGNKLKKQARFARQGQLVPNNGPSSYKEYVEYGGVRRPILYRNPPLVDEEGYEIDSDDEDEERVQEAEASAAEMNPYANIQIERKPVSVESQTSPDIALRRLHMGPMRNDAQHLLALSQAISALPRITNGAAQQASGVEQANAVPDTTFDGEPTDKDPAEDADITMTDAGTADPDDSLVEDADDNAKVEAEKDGAGTASNMHNGEQLPAAQTDKRDSMGEATNGVNEHTNEQGTNETEVARAEATAKPSGSDAHQQTESAETIRADVSMISDGDDDFIHPMFLAPSGARPDRDIGLPDQEAEDIRRLLALYVQKQEEVCRGAKRLFLGLLKAEQMRKNVLHWSKAEAHSGLNRDMSDGEDWYDKEEWGLTEDLKKGQDEEEEDVQTTGKKTRNRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECY9</accession>
    <name>S0ECY9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434822.1">
        <property type="nucleotide sequence ID" value="XM_023582266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECY9"/>
    <dbReference type="STRING" id="1279085.S0ECY9"/>
    <dbReference type="GeneID" id="35406092"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12636"/>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="37"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT72744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="367" mass="40322" checksum="B644642479CE3620" modified="2013-09-18" version="1">MIDRGMGFPADGVDNHGWKLYITSLVMIISSGLFVVARCIARYSIHKLGSDDVAIIVSLISSVLLSTYIQLAIHHGYGMHKADLEKPDLRMALKMFFIAQTPYKATVCLNKVAAILLYLRLFVTKSFRVWSFVVLGVVVGYSIGGIAATIWQCVPIKGAWDKSVDAKCIDSNKFWVAYAVLNILTDVMVLALPIMPIMRLQTSRREKLLLCCIFLLGGFVTIASILRVTSVSNSLRNKKDMTWNFIDRGVWTLIEANLGIIAACLPVLRQPLGKIFPRIFGSTKKSSLYYTGPGGPAKGYNLSDIAARSPRPGIWKSDASRSEQIISVGGPQTEASRDSDERCIIADSVKGSDFGSELATHKPDPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDE0</accession>
    <name>S0EDE0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin POM33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433936.1">
        <property type="nucleotide sequence ID" value="XM_023580383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDE0"/>
    <dbReference type="STRING" id="1279085.S0EDE0"/>
    <dbReference type="GeneID" id="35402343"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08868"/>
    <dbReference type="HOGENOM" id="CLU_065417_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31543" checksum="41C2670766F1D7F3" modified="2013-09-18" version="1">MAPPPNPNLPLQERLLALAKTLQFGWFVGHLTLILTTGRYFLSWIRMNYYTRMAQLSYRTAFIAAAVTYGIVVYKTMRARAKTGARAAPTPMALLADENIQYLAMALVWLFSPQYPLALIPYTIYSVFHVATYTRANLIPVVLAPKPAPEAADGASPSRQAANSPLANQIGAFVKEYYDASMAIVSYLEMALWGRILLSAILFQRRSWILIVLYTAFLRARYSQSTHVQTSFRQLGARVDSLVSAQGTPPAARQVWQGVKEAGKQFHDATDVSKYISGPAKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDU6</accession>
    <name>S0EDU6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434913.1">
        <property type="nucleotide sequence ID" value="XM_023582368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDU6"/>
    <dbReference type="STRING" id="1279085.S0EDU6"/>
    <dbReference type="GeneID" id="35406184"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12728"/>
    <dbReference type="HOGENOM" id="CLU_017513_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="48156" checksum="EE23B35044960A37" modified="2013-09-18" version="1">MTNLKTEPSGLRKALREKYKYEGNGLVTIESICGELGKLLRDYGVEGVNGRFWTDKLLRHILSRARIKAELKRREHGFDDPEVDKYVDKIHPPEAEVSADCTPPGAFLKVFALLVLQERCHDIRHFVNAGFNDQKLPIRIENNTVYPLTGPNKPIACFEGWKSSEKEYFESYQWRVDTPYFSSTADEPLKVHYLHKDTCKPWRRSRETPSDPHDDVSDNMGTFGIVTRVDIHPTSHSYQQLLASINFDCTKFAIKTLHTTSHDNESKFQEEWKMLKLFNGLKHPHLVTALCAFQCAEERGFIFPSAICDLSEYLERREPPRHRKATIWLSNQLLGLIGGPRYVEEFDDARTTMSINGANNNVFYSFTRRPDRESYVVQVKAEVVEWIIKLHQHAYCYEFLHDALDIISKEMIVVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEQ1</accession>
    <name>S0EEQ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to tol protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435317.1">
        <property type="nucleotide sequence ID" value="XM_023567947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEQ1"/>
    <dbReference type="GeneID" id="35403546"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10079"/>
    <dbReference type="HOGENOM" id="CLU_002639_2_8_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="292"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="778" mass="88051" checksum="644CB7FF845DFE1F" modified="2013-09-18" version="1">MPLELRLESDRAIVSSDDNDWIQHIHNEFTDSDLDSINADSIEEIFEKLGKFNVLGLLNLAIRLRDISGSLKGRISSALRNLGFRTPRISIDQEGRCIRCGDMHGIMSYLHEMEMSSKAGCPSCHILATGIRLYLKKEKSFRSGRLMVMKDWNTGCAGRQFVQTNVRSAAMPGALGVRVFLDGGGDVKHLFTDARKVPMKFVGELNFFGLDGSPTSWDLVGLAAEISGDTASDAAFEWFRNQLVHCVQNHRLCNELNAAKLPPRVLDLGPPGTAGLDTDIKLVSSLGQQDRYACLSYCWGGTIDIRLLRNRYHGYLRRIPWDILPQGYQDAIQLTRQLGIRYIWIDSLCIVQDDEDDWRQQASLMAQIFRNAYVTIAATKSRNPNDGYFSVSPSKFIATRIESQAQNGETRHAYVRQTIPHFFSSTASPNRDFTKGNFPLLSRGWVFQERLLSPRVLHLGDLEMAWECNESCACECIGETRTYESELRWTHTKGGYTRRMAEAKSEKDVQPEWRSIVEHYTKTSLTYRRDVLAAISGVVRDMKRHRSDRYLAGVWEDSVLEDLAWMSCDRTKARPSGWNAPSWSWASVAVPVKFPNRRTFLNGRYIQDMEFLEHRTRFVEAGITAVGQDETAQLSAAHMVLVGPMISAKLDEDPDILSQRQLYLATNRDRSLVFAPDYDLEREGPSCVPMGTTIYILHLCQEPKFSDEKRRDTTRKAFSLVLRRLHGLNGSNGQMVRSSEDPTDGTYERIGIMFQGPDQAYSEGYVAAHGVDCVVKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEY5</accession>
    <name>S0EEY5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433012.1">
        <property type="nucleotide sequence ID" value="XM_023580192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEY5"/>
    <dbReference type="GeneID" id="35402514"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09040"/>
    <dbReference type="HOGENOM" id="CLU_1396429_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485175" evidence="1">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="195" mass="22018" checksum="45BC4E603575794F" modified="2013-09-18" version="1">MSALLFLTQLLSLLPTFHEFTSYCYPHLCLNDLNSGSALVSNSHKFAHDSRSTFRPNMSVDTWRLPYLTTGADDMHIRPAFSKQQFKPGIVPISLRGSVSRISISSIVTVPLAVQERYSQKPRQHTRTLRVSIDHMSLATRVFSTTEPGNKLWVVDWRTPPPLSDRSFPAPSSHGDTFPIWPSCPLLLVLKEAYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF57</accession>
    <name>S0EF57_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434565.1">
        <property type="nucleotide sequence ID" value="XM_023581959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF57"/>
    <dbReference type="STRING" id="1279085.S0EF57"/>
    <dbReference type="GeneID" id="35405818"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12362"/>
    <dbReference type="HOGENOM" id="CLU_647321_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47409" checksum="C6A87D8CDA6569D5" modified="2013-09-18" version="1">MDGLSVAASCIAMIQAADQTYKIISQFLKDLVLNGCNFVDRDLTNITKRDIHEIVSSCLAVASDIDDVLSGHQGKLVSLSWATRGKRKVATSKVLLETNRRALSLAVDNITLATAQNIKQDTANILGDTTHMRGDIHDLVSRIRNLEVMVADKDPDDPRKYVLMRYLNDLSSVAKSFSSITIEIQKLTRIKSLLEDIASLDTSRKTSPDANTNKNEPKFSALPKPGSISEAITDQKLPIEPTDSLKKSQIEILTTDASLLLARIKTTTGEPGRLLLPVYHEQDEIAIAGLVPGSSTRVLAIRFPSNAHPEDVIITGQELSCSGSDAQKLPHRLREKQAYTYRRVCSDGKGIISEDRWLIQTKAIDAYGEFIRQIYSMRAIQLVPEWPQQLNVFLPNFDQWLRMRKGKGEDNRKSRIYFETFELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF67</accession>
    <name>S0EF67_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_09588</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435684.1">
        <property type="nucleotide sequence ID" value="XM_023568492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF67"/>
    <dbReference type="STRING" id="1279085.S0EF67"/>
    <dbReference type="GeneID" id="35403056"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09588"/>
    <dbReference type="HOGENOM" id="CLU_002833_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF228">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="5"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT73606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="349" mass="38388" checksum="BA559F721A1D406F" modified="2013-09-18" version="1">MSTQYINAVYYPSWRCYKERPPSCLDTASVTHIFYAFVGVNEDGTLRSIDDWADNNKAVDGEKGCLAALRKLKGQHPHIKTLVSIGGGSSSKEFPALAASRAARQTFARQIKEFCDTHHFDGVDIDWEHPQTPEAGNNYVLYLQAIRETMPAPKYLLTSALPTGEYCLKHLNLLVVAQLLDFLNLMGYDFTGGWTDVCGHHAQLLPPSNNLNEVYPTLRKSCQRGVDYLTSQGFPSRKIILGIPVYARYFGQARGPGHPFKGSGEIDYCDLSDEWVAGAKVDESVAAASFVDTKGDKGFVSFDVPSTVCVKARYAKAMGLGGLFYWTGAGDRASHESLVAAGWKTLHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF79</accession>
    <name>S0EF79_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to sexual differentiation and meiosis protein ste20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_09572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435699.1">
        <property type="nucleotide sequence ID" value="XM_023568510.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EF79"/>
    <dbReference type="GeneID" id="35403040"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09572"/>
    <dbReference type="HOGENOM" id="CLU_001013_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="4">
        <location>
            <begin position="96"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1328"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1229"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1328"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1360"/>
            <end position="1369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT73621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1389" mass="155027" checksum="6A6C07CC2EFD2320" modified="2013-09-18" version="1">MLSSSAAAQKGMTPPSQPSQHNLPQQLSGRTSFDRGDSGLQPPNGANARNLSASAVSFAPRGSSLNVAPGSFSSELRSRAGSKTEAGSIYPSSFMDKVEEDDADTLAEQALAHLKERLNREMKIKEGSENMLEALNSKKAKQTKEQRQKVEAELNASNSRIKDLRQKISDAQHTRQIPPATPKRNRTQSNVIESGRPIGLRSPQSVSRSVVESDNEEPTESPTFALAELLQALEVEGMMPEYYVSRGNQLVDLFKRYPTLKYDLVWSIFGLRMQVMLLSESREVVAAGYRMTRYAISDVASLKKIRSLNTDYLVIRSLNNYRKADVEREQALKFVRAFLDVKGGVKEISRAVVRTIVAVAEHGEDRRANAQPAEGDLDRLRPICIETLAEIIVQDPALLVASGGLGPLTEALSEGVYKSPESLTSAFLYLLDSPRKRKYIQPGYGLEVLFTVFTDHLLTNESIMKQNSKAIATALKSWPGLMTLCMYDLRTIRSLITSMLLPSDVVRETILDLIFSLLRIKPPAWATSFLAGRRLTTYGRVANLKSNQKDKSHLQFTEEDSGEQNFVEHYTALLLAVLIRAGLLPVLLKIAQGDENPTLQRKTTLLISEVLKLASRLLPPSWSAELHLLPELFSSAANIGNNDHWVASGIVYQISSVSRTLYRSAPTGALSGALSSGHNSNDISAIDEAPKSHQSLVFDDATFRQLLIDSNVLNSSNYAKWNWETILKIIDGPLQSGKRLEEAIKASKFMKRIISFYRPFKYRFANVKNTRATQKYVRAGCALMHSLLQSPEGIKFLADSKLLRQIAECLAQCDPTSGLTAQYPMFSRDRVTDTLCAGYFSMLGVLSGDPKGLQLLERWRMFNMMYHIVDLKQRPDLIKLLLSSFDYSVQGHPRVLLSKALTAGTKEIRIHATNALRKYAIRPVPSANGQGGVSDSKWAIQLLVTQLYDPEIEVCATAVKILEKACNRKTYLEYIVECRPALDHLGEIGAPLLLRFLSTSIGYHYLDGLDYISNEMDDWFLGRNDTYVRVIEASLARAFLVDPDEHNPRMSLFDDSEMDGDYHDNHVPPHFYRELTRTQEGCRLLSDKGHFEDFAATIREHGMDKGDAEILTKVKGCLWAVGNVGSMELGAPFLESNDVVEHIIRIAETHEVMSLRGTAFFVLGLISRSTHGLEILSEHGWDANTTPMGTSLGFCIPNDLSRLLSLTAWKQKTVTSITLPSSQRTAQEAPPPRAARPPLEPAEIPAMLSEADVNRRVLELIVDLGNMVLYKKALTDLQKLRAHKPSAFKSTQFFKEVMSAMEWNHYRLGVRRMVIDLFDKNVMRQIVFDEEEDDEDDDSSDDNSQEESEEESGEGENSSGDDRTERQRSISEPPAPPPDLTPAPLRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF86</accession>
    <name>S0EF86_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_09560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435709.1">
        <property type="nucleotide sequence ID" value="XM_023568523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF86"/>
    <dbReference type="SMR" id="S0EF86"/>
    <dbReference type="STRING" id="1279085.S0EF86"/>
    <dbReference type="GeneID" id="35403028"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09560"/>
    <dbReference type="HOGENOM" id="CLU_039228_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00443">
        <property type="entry name" value="ADA_AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT73631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="330" mass="37138" checksum="19C089DCB1B2D6E4" modified="2013-09-18" version="1">MCKLHAHLTGSISRRALHEVWLRKKETGDTDLEDPLIVMPEGKHDYNLQTFFPLFSSYIYNLITDEESVRYTTNSVLTDFLDDGVCYLELRTTPRATTQLSAEQYISTLLDTISSFESQNSQLHTRLILAVDRRHTPEQAASTLELALRYREQGVVGLDLCGDPTARPTGEISAFTPVFLEARRKGLGITVHFAEAEASGSKEELNTLLSWEPGRLGHVIWEDEETKKEIAKRGLCLELCLSCNVRAGMVLGGFEGHHFGHWRGVNGPKISLSTDDVGVFGSLLSNEYRLVAEHFGLDRQAICELARQPIDGIFGGEREKERLRDIMWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFP6</accession>
    <name>S0EFP6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate-semialdehyde dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="9">1.2.1.16</ecNumber>
            <ecNumber evidence="3">1.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD(+)-dependent succinic semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_09642</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="9"/>
    <dbReference type="EC" id="1.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435632.1">
        <property type="nucleotide sequence ID" value="XM_023568433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFP6"/>
    <dbReference type="STRING" id="1279085.S0EFP6"/>
    <dbReference type="GeneID" id="35403110"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09642"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT73554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="494" mass="52791" checksum="9E4AE74D28F163B5" modified="2013-09-18" version="1">MAESYHKEVIAGLKDKSLFIQDAFIDGKWVAKENKFDVFEPSTATVLGQVANCTLEDFQTAIKSADAAQTKYFDSTTGASRGALLRKWYDLVLSHQEDLAKILSLENGKTYAEALGEVIYSASFISWFAEEATRSYGVTIPSSSPHTTLMTIREPVGVCGIITPWNFPAAMITRKIAPALAAGCSVVIKPPSETPYSALAFTKLAIEAGLPPATIQVLPTRDRQAATELCTNPLVKKISFTGSTGVGKYLAKLATGTLKKVSLELGGNAPFIVFEDADLDLAAEGAMFCKFRCSGQTCVCANRLYVQKSVAEEFTAKLVEKVNALKMGGGLDKSTTQGPLVNKSAVDKVKEHIADATSKGAKIATGGSTPDSPGFFHQPTVLTGVTQEMAVAKDETFGPLAPIFEFETEEDAIRLANDTEFGLAGYFFSKDISRVMRVAHKLQVGMVGANTGKISAAEAPFGGVKESGYGKEGSLYGMAEYQNIKSITIGNLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EG88</accession>
    <name>S0EG88_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multiple epidermal growth factor-like domains protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435882.1">
        <property type="nucleotide sequence ID" value="XM_023568731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EG88"/>
    <dbReference type="STRING" id="1279085.S0EG88"/>
    <dbReference type="GeneID" id="35402843"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09374"/>
    <dbReference type="HOGENOM" id="CLU_026722_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157:SF2">
        <property type="entry name" value="EB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157">
        <property type="entry name" value="PRION-LIKE-(Q/N-RICH) DOMAIN-BEARING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495899" description="Multiple epidermal growth factor-like domains protein 6" evidence="1">
        <location>
            <begin position="20"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="61685" checksum="B858351634E25EEB" modified="2013-09-18" version="1">MHIKYLLINLFALTVSVKALPDADNDFGLEARDDSDTLVQRWDCGHDAKEVYGKCVCNDKQLTWNGKKCVCPKDTTWQYGKCVPNKPTCPKPQVYNPHSKKCECPSGTEWKYGKCIPKCPYGQSYDKDQDKCVCPKGTEYKYGKCIPKCPYGQSYDKDQGKCVCPKGTEWKYGKCIPKCPEGQSYNQHSGKCECPAGTSWKYGKCVKDCPKGQYYNQHKDKCECNKGTEWKYGQCVPVCPKGQEYNKWSHKCECPKGTSWKYGKCIKDCPKGQSYNPHSNQCECPKGTEWKYGKCIPKCSNGQYFDKDQWKCVCPKGKIFEYGKCVCPENQVEKYGKCVCKDGFKFEYGKCVPECPKGQTYNKHTKKCECPSGNVLKYGKCVCPDNQVEKYGKCVCKDGFKFEYGKCVPQCPQGQTYEHGKCVCPAGKVYNKWHKKCECPEGKVEAYGKCVCPKGQIEQYGKCSCPKGQYYDRWSKSCKCPKDLSWDGHKCAYDCGKDAEYKYGGCVCKKHDQVFDKKSKTCSCKKGWYWDQHKGACKKGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGE5</accession>
    <name>S0EGE5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable phenol 2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435947.1">
        <property type="nucleotide sequence ID" value="XM_023568808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGE5"/>
    <dbReference type="STRING" id="1279085.S0EGE5"/>
    <dbReference type="GeneID" id="35402774"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09305"/>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="455"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="663" mass="74435" checksum="ECD01F7848B54774" modified="2013-09-18" version="1">MAVGAKTDHVDVLIVGAGPAGLMMATWLAKCGIKTRIIFNGQADGLQCRTLEIFDSFGFAHRAWIESNHMLEISLWNPDEKGVLRRSSRIADTIPGISRFQQVVLHQGRIERFFLDAINDFSQGKIEVERGVMPTSLEIDPKAVEDPDAYPITVNLRHLSEEEAQPKQTSTSANGTTVQDGLFRSNLSPDDTADMLKAAELNDKANTVEVVKAKYMLGADGAHSWVRKELGFKLEGESTDYIWGVLDIVPITDFPDIRQRCAIHSASSGSVMVIPRENKLVRLYIQLTTTAKIGDQDSRADRSWITPDVILESAQNILAPYKLTYRKLDWWTAYQIGQRVGSNFSAYDRVFLAGDAVHTHSPKAGQGMNVSMQDSFNLGWKVANVVKGLASRSILKTYETERKGIAKALIDFDHKFSRLFSGRPAKDIMDEEGISMDEFREAFEKGNLFASGIAVDYGQSNIVAKITSDDSGLKDIAVKRQALAPEIKLGMRIPSVKVLNQSDARPWHLQELLRSNGSWRLLVFPGDIDLESQNKRMRSLCDKLSAESSFLKRFTPPSARYDSVIEVITVHASKRQDHEIFDFPEVLRPYHEVDGWDYNKIFVDDESYHEGHGKLYQTFGIKVDQGCVVILRPDQYVSYLGDLDDYDALDGFFSEFMIKQETV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-10-25" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGU4</accession>
    <name>BEA3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC transporter BEA3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Beauvericin biosynthesis cluster protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BEA3</name>
        <name type="ORF">FFUJ_09294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Environ. Microbiol." volume="18" first="4282" last="4302">
            <title>Sound of silence: the beauvericin cluster in Fusarium fujikuroi is controlled by cluster-specific and global regulators mediated by H3K27 modification.</title>
            <authorList>
                <person name="Niehaus E.M."/>
                <person name="Studt L."/>
                <person name="von Bargen K.W."/>
                <person name="Kummer W."/>
                <person name="Humpf H.U."/>
                <person name="Reuter G."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="27750383"/>
            <dbReference type="DOI" id="10.1111/1462-2920.13576"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">ABC transporter; part of the gene cluster that mediates the biosynthesis of beauvericin (BEA), a non-ribosomal cyclic hexadepsipeptide that shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic activity (PubMed:27750383). Functions as a regulator of beauvericin production, rather than in BEA transport out of the cell (PubMed:27750383). Beauvericin has low toxicity to the producing fungus and BEA3 does not play a role in detoxification and self-protection of the producing fungus (PubMed:27750383).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">Expression is highly repressed by the histone deacetylase HDA1 and the beauvericin cluster-specific repressor BEA4 (PubMed:27750383). BEA biosynthesis is also repressed by the activity of the H3K27 methyltransferase KMT6 (PubMed:27750383).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Does not affect the production of beauvericin but increases the expression of BEA1 and BEA2 (PubMed:27750383).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGU4"/>
    <dbReference type="SMR" id="S0EGU4"/>
    <dbReference type="STRING" id="1279085.S0EGU4"/>
    <dbReference type="GlyCosmos" id="S0EGU4">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CCT73880">
        <property type="protein sequence ID" value="CCT73880"/>
        <property type="gene ID" value="FFUJ_09294"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09294"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000442148" description="ABC transporter BEA3">
        <location>
            <begin position="1"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="858"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="880"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="961"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1 1" evidence="3">
        <location>
            <begin position="54"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="2">
        <location>
            <begin position="378"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1 2" evidence="3">
        <location>
            <begin position="735"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="682"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="413"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="27750383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="27750383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT73880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1301" mass="143705" checksum="C1549EA95B48CD17" modified="2013-09-18" version="1">MGKRTAENSAANGEGEEKHPEIGVDGRPEKEPTFQDYMRVFKYASKWDLLAYTVGVIASIGVGITLPLLNIVFGQFASKFSDYAGTETLPGDEFRSKLSELCLYLLGLFLGRLVLGYITNFAFRMTGVRITSAIRQDYFTALFSQSVHVLDSMPPGYATTIITTTGNTLQLGISEKLGVFVEYNATMIASIIVAFIYSWQLSLVTFTAVVFITFSVSLVLPYITKGQTNQTKSEAMAMSVASEAMSGIRMIVAYGAESRIGSKYGRFVDEAKKHAQFAGPFIALQYGLVFFSSYAAFGLAFWYGTRLLLEDKINQLGAIIVVLFSVMMIVTAMERISTPLLAVSKATVAACEFFTVIDAPRPEPGHLTDPDVSATEDIILEDVTFAYPSRPHVKILDNLNLRIETGKVTAIVGPSGSGKSTIVGLVERWYGLKDQYVISKPVEKPTDKKNNGGKEEDEQELQELSFAGDETGPPVDLHGRISTCGHSLDDINVKWWRSQIGLVQQEPFLFNDTIYSNVLNGLIGTKWENEPDEKKREMVHEACKEAFADEFIEKLPEGYNTAVGEVGIKLSGGQRQRIAIARAIIRRPAILILDEATSAIDVRGERIVQAALDRASKNRTTIVIAHRLSTIKKADRIVVLRQGQVIQSGTHEGLLTDEAGLYYNLVNAQALSLGEQKEGNEVIAKEERPSSVHEKAHTESTIEEKPLEKKPKNKGLLSSFGRFFYETKSNWWMMALTLFFSACAGAAVPFQAWLFAKVIIVFGYLPDESKVRSESSFWSLMWTVLAISAGLAYCATFFLSTRTASTIRAKYQKQYFLYILHQKVAFFDHDDHSQGTMAARSAEDPRQLEELLGSNMASVFIALWTLMGTIAIALAFAWKLALVSLCVVVPILLAAGYWRMRYEIKFEEMNNAVFVDSSKFASEAIGAFRTVASFTLEVAICDQFRTLNSNHVKDAFKKARWVSLLYAFSDSATIGCQAIVLYYGGRLLLSGEYDLESFFVCFMSVLNAGETTGRALSFGPNVAQVRAAANRILGLRDSQVKDGPEATGEQFISHGDGIEIELENIYFKYPTRDVPVFDGLSLTIEKGQFAALVGASGSGKSSIVSLLERFYDPDHGRILCNGQDIATNNVYTYRRHLSLVAQESSLFQGTLRENILLGVEDTVDDAAVHRVCQEASIHEFIMSLPEGYQTQVGSRGVTLSGGQRQRVAIARALMRNPDILLLDEATSSLDSESEKLVQEAFERAGKGRTMVVVAHRLATVQNADVIFVLGEGKLIEKGSHRELLAARGVYWQMCQSQALDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHD4</accession>
    <name>S0EHD4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to DUF1479 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436267.1">
        <property type="nucleotide sequence ID" value="XM_023568991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHD4"/>
    <dbReference type="STRING" id="1279085.S0EHD4"/>
    <dbReference type="GeneID" id="35403697"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10232"/>
    <dbReference type="HOGENOM" id="CLU_011148_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="459" mass="52174" checksum="ED0914061CB742E0" modified="2013-09-18" version="1">MSYTETEQLELSQQLLLDCNLLDQRFAALKKSLVKPENKQKVIESYERLVKILRKEVDHIDKHGAALVPEIDFDDVRKNGGKLPDDFTKLVHERGCVILRNVVSEEQAVSWETSLKDYTKRHPGVGGHPHHKPAAWNVFWTKAQMEMRTHPRVLEAMRCVSRLWHVSDPTIPIDLDSQVIYPDRIRIRYPSNDPGQFPLDPHMDSGAIERWEDDENRKNYAAIFEGNWQDWDAWSADHRVTAQSDLYHTGTACSVWRSLQGWLSLSNTQTGEGTLRVLPSLKLSMAYIMLRPLFHTGEYNDSLPTFPGATPGQTQFFPTVEGHPDLDIKRAIVGIPPVRPGDYVFWHCDLVHGVDPTNPGLVDSSVSYNACNPLTPYNIESLLTTREAFQKGDVPIDFTRSHGTWEREYDHEDCGARVENILTKAGLQAMGLERLDTEEEGLTQGQKEVREMANGKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHF2</accession>
    <name>S0EHF2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3669 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436123.1">
        <property type="nucleotide sequence ID" value="XM_023568210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHF2"/>
    <dbReference type="GeneID" id="35403310"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09843"/>
    <dbReference type="HOGENOM" id="CLU_039531_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022137">
        <property type="entry name" value="Znf_prot_DUF3669"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780:SF3">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12417">
        <property type="entry name" value="DUF3669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3669" evidence="1">
        <location>
            <begin position="247"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="337" mass="38020" checksum="26C3707C1CC2D250" modified="2013-09-18" version="1">MATGVSHDLTTQSSPEKLLHIGTGCCGSVWADADSSKDNGTPSCIKREDGDPHRSITNEHFIHQLVVQSLQLNPQHARNFRIPLCRGFLKKDDESWSLVLPRLPPGSKPCNALLSEKVQPLSEDVRKLLVSKFARGGSDQDAIINDKKNEHCLIRPYLGRRKRDWGDTNRSTFFSLRNFPLHLDRMIELGLDVQSYAKVMAEGLAFLHWVARIDANDVEFVLARSRSTSHSHPNSPFDKTLFGAHSMWIIDFDCCNPVTMDENGAANAAECFWRNDPYYPRPGSTDTSDQELWCAFKDHYLEVSGEILKKEEQSVKDLPKLLIGIIEEGPKFTKENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIC4</accession>
    <name>S0EIC4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to transcription activator protein acu-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436849.1">
        <property type="nucleotide sequence ID" value="XM_023569669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIC4"/>
    <dbReference type="STRING" id="1279085.S0EIC4"/>
    <dbReference type="GeneID" id="35404304"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10840"/>
    <dbReference type="HOGENOM" id="CLU_007426_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT74771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="612" mass="68991" checksum="4085EE44318F65EA" modified="2013-09-18" version="1">MTNQSLAGHITKFRVSQTPRIKRNRPAVSCSTCRARKQKCDRQQPCGPCQKRGVEDSCHLDSTPRPPPPSLANRGNTRVQNELRQMQSLLQSLLSQPNQDQAATSCDTLAAGVDRIRQAISGNTSSALTAPQVDQPPDIVFGSLAKATSEDVLAALPSRQCSDKIVSTYLNARHIAVPFIHIHQFRRRYEAFWNNPESANLLWASILFSVLAVGTIIPDDKEGRCQSSAFISMSARCLVSGQYSTATEFSVEALAMHLHARCFHQEDSNINLSQLHALAVRIAQQRGYHLAGDDFLQALTPFQVEMRRRVWYYLQYYDVLLSLEHGLPPVIHEDTYSIGHPTNVTDDEFDEESKIIFSSPTTEAYAALPCVYMSQLLPILRRIVCHALGFKTYNYKDALFLRSQLETWYRSIPRCLCVHSVKNTCLTNTASAALHRVLFQLIYNTGIALIYRPFLNIMSLENKNFKTALDLSRKNALRSIEVYIEVGQEMQSGGGLYHNPQVKANLPVNDFFITMIMAPLEFFGCPDLPQSQKGYIIHTLETAAQLWPTRSCVSSYALESSRLLQVILADIYSSTSIERPMYPLYSKPGKCPLAMLWNLWFKKWGWLGELVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ88</accession>
    <name>S0EJ88_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434521.1">
        <property type="nucleotide sequence ID" value="XM_023581911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ88"/>
    <dbReference type="GeneID" id="35405774"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12318"/>
    <dbReference type="HOGENOM" id="CLU_1570784_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="170" mass="18822" checksum="83CB890393887A7C" modified="2013-09-18" version="1">MSTIQTAMAQLLPAERQAYEGKELLSLNAAISRTLLTIETDCQLARDLRKIQIRIRRHILASLVEEDTADTAQGPNQHETSLKDILPPPDTILPSIEQELHYDHARLSTPTVGGTPDETSERKRCPTPPISDGTSDEFPMGKKRPADNEFGSAAKRPRTWLSTITRGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK31</accession>
    <name>S0EK31_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434826.1">
        <property type="nucleotide sequence ID" value="XM_023582270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK31"/>
    <dbReference type="STRING" id="1279085.S0EK31"/>
    <dbReference type="GeneID" id="35406096"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12640"/>
    <dbReference type="HOGENOM" id="CLU_013987_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="664" mass="75600" checksum="7EE0B1FB6C30A6C1" modified="2013-09-18" version="1">MPNPRSVRSSQRSVLACTNCSRRKIKCSKTIPCIACVRQNKAAQCQREPVAVVSRRSVGRSRASTALDDPPPVIVPVQEAASLAQVSPTSIDEVATVNPTAGSIATSTNEFLPHIDERMIEQLLASLSTPDTRLTNEAAAMLEFLTHGRRNILNQFIGRESVSTSMTQPVQKWDTFLPVGDARSLLVLHGKYLTWMHNTVHMPTFLREFDENILKVECDRNWIALYYALLSQTLYHLDSDYLSSLPQPITVDSKASRILFDRSREMLYKAEFMDKHKLTSVQTICLLVQVAHNFDKSDLICVLVSAAIRIAQCLNLHRLGFDDPGADVNEVIDREVRKRIWWFLVRYDWLQIPFQNTCQIHYSQFNTPMPANCHDDEERMIKDGKIDAQPAEISTITTWTNCLAQMAIVMWRHHDRMLRVGNSQAGEFDRKYDEVVRADEEIKSLYLSWSDTLRDVNTTPSDNLAIDGLPTALMPAMLLMSIAQKIFTVHRQFQLSCFRDRRYAFSQLSCVTIAERSIEAFQRWSDCVEARICRRMWTTLSYMISCSITLLLALLFKAQNALTHDWERLRAYVEYGKAFIGKEAQASSIARRGVRLLDALMELERTSRFSSDIEADIGDTIRRVALADDGGVEANSGEGYQMVFPYGQDLWESLMRDPNEGEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK53</accession>
    <name>S0EK53_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437439.1">
        <property type="nucleotide sequence ID" value="XM_023570310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK53"/>
    <dbReference type="STRING" id="1279085.S0EK53"/>
    <dbReference type="GeneID" id="35404875"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11413"/>
    <dbReference type="HOGENOM" id="CLU_063299_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="299" mass="31549" checksum="B110CF9EEB38B3CE" modified="2013-09-18" version="1">MPSARTNLGPLTTEWKYPDRCTVPVTDCTTCTNAWQGQTCGNNKDNTQGVLDDTDCWPPRKSFISAGNAVNGWGFYSPAFECPQGYEKACTATGPETGNFNFQFSIQDDERVIGCCPSGYTCAQPGGPQTCTTIASRGSLQVASCSNQKTVLNWLTLPATVTDETSTVSLDGITIFAPMIQLNYREKDLSLSSGSTGSTKTDSAPAETGTGESFSYSSSSGGLSTGAKAGIGAGVGVVGLAIIGAALYLWRRRKRATPQAAELETKEDTKNAGSVLAYGSPPPQYPPVELDATNSRHEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL15</accession>
    <name>S0EL15_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to cytochrome P450 monooxygenase (LovA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_11743</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Plant hormone biosynthesis; gibberellin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437754.1">
        <property type="nucleotide sequence ID" value="XM_023570677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL15"/>
    <dbReference type="STRING" id="1279085.S0EL15"/>
    <dbReference type="GeneID" id="35405204"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11743"/>
    <dbReference type="HOGENOM" id="CLU_022195_0_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT75708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="495" mass="55090" checksum="4DE59FAC1B536EE1" modified="2013-09-18" version="1">MDVSKHITSLLAGQSPVVGAVLVAVVALALLMLIVPKDNIPVINKYPNDWFLSKAHMAFITNADGLIKQGFAKFNKPFRMITLLGDRIVLPADHFEWMRRHGPHLDHQPLVSKDFFAGYPGFDGTAAISDPSKLLANVIKKKLVQNPHVSKLHNMVRKDIVAAWPGQSDAWKAVDWAKDGVSFISRMSASVFVGEELSRDETWQQVSTNYGMTVFLAARALRAWPRFLRPIVQWFLPACKSCRAEVQRAREVLQKNLAKRAAEDKEHDDSITWFGEIAGGKSYDPVAAQLGMSMAAVVTTSELLKQTIIEICAHDLATPLREEIEAVVAEHGWTPAALTNMRLLDSVIKETQRLNSAVIVNLDRQVLSPVTLPNGQYLPKGTAISIYMSQLRNPEVYDNPDTFDAYRYVKLRAQGGKWIYASSATSTSEDHFVFGIGKPICPGRFFAIAEIKTAIATILLDYDLRLAEGYTPKLMPFGFELFADPGVQLEVKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELJ4</accession>
    <name>S0ELJ4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to translation releasing factor RF-1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_10060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435336.1">
        <property type="nucleotide sequence ID" value="XM_023567968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELJ4"/>
    <dbReference type="STRING" id="1279085.S0ELJ4"/>
    <dbReference type="GeneID" id="35403527"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10060"/>
    <dbReference type="HOGENOM" id="CLU_036856_0_8_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT73258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="426" mass="47891" checksum="4C8F68AEBB5509D9" modified="2013-09-18" version="1">MSATPWICRACTRALTRSHMRQFVRFATNDASPLLAPALLQRAQSLTTEHDDLQKTLNNSFDSSIAKRVGELSRVAEALKAWQTSQASVAELTSMLDDPDQDADLAAIARDELSSETGKLESLARRLSASLTPRHPFADFPCMLEFRPGPGGLEGRYFMDTLFKMYKALCMRRGYRHTVVKYEFADTAGDSSSSAGENPLQEAILEVHDQGAFDIFRSEAGMHRVQRIPSTETKGRVHTSAVAVWVLPSFPENGAANIDFDDPESDFYVNPQEVKIETMRARGAGGQHVNKTESAIRMTHLPTGTTVSMQDHRSQQRNREEAWKLLRSRIADQRREAREEEASNLRNSVLSKTQITRGDKIRTYNYNQDRCTDHRAGVDVHDLPNVLEGGEKLDRIMDGAKDWLVNKDIELLMAEEEAKEKHNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMG1</accession>
    <name>S0EMG1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to D-arabinitol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437155.1">
        <property type="nucleotide sequence ID" value="XM_023570027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMG1"/>
    <dbReference type="STRING" id="1279085.S0EMG1"/>
    <dbReference type="GeneID" id="35404624"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11160"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="295" mass="31858" checksum="A1FF25C2A6B9B0E9" modified="2013-09-18" version="1">MGTSVTEAQTAAGEPTTTVAQQHQTKVTLIGKVIAITGANRGIGLGVAEACLDNGAQVVYSIDYAEPGQDFAAAQERWQGKLKAIQADVTKEATVTAAVDQIVESEGALHGMVVNAGRTNHKAALDFTEEEIRNLFDINVFGAFYCARAAARAFIKLNIKGAVVFTASMASYRPNKRVPSAPYGASKAGIRNMTHTLAMEWAKYNIRVNSVSPGLVDTAMTYWVPQQPDWEQQLKYYGGMPRLAQIQELGGAYVYLLSDAASYTTSIDIPVNGVIGSMLHILLLYRTLLICFKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMP6</accession>
    <name>S0EMP6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437958.1">
        <property type="nucleotide sequence ID" value="XM_023570917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMP6"/>
    <dbReference type="STRING" id="1279085.S0EMP6"/>
    <dbReference type="GeneID" id="35405420"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11960"/>
    <dbReference type="HOGENOM" id="CLU_020336_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="32"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="301" mass="32526" checksum="AA7EA7746F452587" modified="2013-09-18" version="1">MATQQTAKTQYVKSPNGATFAYRQIGNASGIPLVLLTHFRGTMDKWDPVIVNSFAKNRRVITVDYAGVGLSTGDVATSMRQSAADITQFIELIGEKEIDLLGFSIGGYVAQMVALNADPSKVKVRKLILAGTGTSYGPDLVYSQNKDVGSVAGVKDVDINVFKTLFFPKNAAGDAAAEAWWSRIHERSAATSGEEASLWLSSGYKDGGKGLVGQVTQGHDFTESPEKSKGEDGAYDRLPDLKIPVLVANGSNDYMIPTPNSYLIYQKVPNGQLILYPNSGHGFLFQYAPTFVKHVETFLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN27</accession>
    <name>S0EN27_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_11861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438098.1">
        <property type="nucleotide sequence ID" value="XM_023570806.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EN27"/>
    <dbReference type="GeneID" id="35405321"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11861"/>
    <dbReference type="HOGENOM" id="CLU_001693_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="985"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1554"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1638"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1563"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1641"/>
            <end position="1651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT76052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1687" mass="185962" checksum="B5C3F747C4E1E00A" modified="2013-09-18" version="1">MSISSCPVSGSVGGECPVGGGSSRSGQTRRGCAFSAAAQPGDLHAAFDIPRGVDTEEWLRARERKTINELLYADYPSREEVDSVKSQQELDAMNASDHDLLAIALGAPARQVLQRAQEIGPQTGWRDGYLSVEHGFCPPDYEEPIAALARSPGRIWSDLCERMPGCCARGRVREAVAALPLVKGTEENIPDQALWGAVVALGMLCSIYRFEDKHDGKDGLAITEGVTTKPQCPMGDDLCEELEGIPLCIALPYYQVSRRMGRTLPHLSFPDQASYNLKIRDVKSNTPYLARFDNTDLRWPMFGERAEVAFLKGCADTSASFQHGPDAIAACQEHVMTGNIEGLLHEMIRLKEILERMPNAFHSISPNPNAGDNYVSADKWVRWGLFSSPLSRRVPAASGLQFPPYLVMDAFLGRKTHASFLGVEALHLRAWLPSNHRAFIAAIQYHYSIPEFVQRSGDPRLMGVLEGIVEAYAGERGFMGVHRYKVFGILEVAAKTGRTATNGLSGAADATRPWEETHRQFSDAMKERLEPFRGKLAMEPHSMRGTFEECRYMAKIASCSSIDQDASRSTAMVTLDIRDTGITFAPGDRVAVMPLNSWEECAKMVAALGLDQHVREPVDTTGTWSRFEHHLSTVTRTAHRQLTVIDILRRGHLAPITKELTVKVHELLHASSNTVLQVLATEEWPVRGSLGDLLQKAVLDTPSHIWNRAFNLQDLSWLSDLVQLEVPRTYSISSHSNDLLPGTVDLTISRAEYELSPIFSHGQTVTRAGVASGFFNPRPLSPENSLLYEVLIGVSRPVAFQLPIDKMVPCAFFAGGSGIAPFRSFWQHRLATSGLSGGRNLLYLGVQSREKFCYEAELRELVNMGFMEVHLAFSRDRHGLAYDSAARDLVEKPTPPRYIDSLIVEQGNTICDMVMSKKQGGLGGHLYVCGSVSVFDSVMSGIRKAMYNYRTATMETVDLIINKAFAERRFMLDVFMSPKALPCNLPTISLSSLALHTGHRQESRMWIAVHGSVYDVTDFCPMHPGGTLIIKSNAGVDCTKSFDNLAHTNNPEVSSLLTRYFIGHLAPKPDYRDSDVSTLHDLWASYLRVTVETLVAHQFEMNDIMGESIDSPSAYDPNGISNIWLREGLPNTIAIRTFYDYQNRLLQGGFAALFGSKLEELVLRLSFNFANSGGPGAASKLPDILGTIARAKSGSDAVRSAKEISALGDFVCDPSSELRFQERGVLDFTAKCVHLDIELLEDLRQEACNGMDAFESIATVLDSFDGSNSDSTPVAALSSFLLQTLERMAHRLAMFYTQLARLSVYQPELEHNPARTRWAFVRRCIRDGTFFVMTRSRSSEAPLNGQSESYYINAKSLEKTTFDDILSQIKHVITSSTVESPTTAVQLATVNDVHLERVNTLGKDGAVASSASRLNVGAVESMGNFMKKNEKAIRRLSSMPNQLQLEDLQKAITMNEKPDLQKSESLATMDASPSRFKPLELKIALELDPNALLACKDQMITARMRIMGGYEMMSCSASRLSAPVKCTSISSISFEEANELVVANPQPLMERLKSIPDDESVPSSASCTTTQSRRSSFSGSSVTGSVAESFAPTPRSRPYETSMALKLKLEGLNRRSRGESVSSRQSFISASSAIDLRRNRSVSSNRSASKRMSIDPGHSREQSAGRLLAFKLGALAGERRSFIPPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENN3</accession>
    <name>S0ENN3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436321.1">
        <property type="nucleotide sequence ID" value="XM_023569051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENN3"/>
    <dbReference type="STRING" id="1279085.S0ENN3"/>
    <dbReference type="GeneID" id="35403751"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10286"/>
    <dbReference type="HOGENOM" id="CLU_071337_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="265" mass="31192" checksum="E873D359AE9D73A4" modified="2013-09-18" version="1">MAELSEIFSFLRQPSRQSGTMKRRPIYKFHPENSCYKNWGFAIYRTYYGAESDTPWKTLLEVLKQQTLLSVGYYENEHIWKRDWKWYMGPWKDKAKYVASLDTFKSLFRLLPKEDPLLLKDLDIKDLRDICQKEHPEAEERMAGASFCFVLVADKAVLDGIARNEFLVKALGYDWEGHIEDGGWGWVRLETGRLLELWEALLLSQLMDNSKYYSLGFEGPERDLETYLWDGDIFIPPLCDCSKAEMADPLTVSVRPWFTFNHQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENZ6</accession>
    <name>S0ENZ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to 6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436576.1">
        <property type="nucleotide sequence ID" value="XM_023569350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENZ6"/>
    <dbReference type="STRING" id="1279085.S0ENZ6"/>
    <dbReference type="GeneID" id="35404017"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10553"/>
    <dbReference type="HOGENOM" id="CLU_040056_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="573" mass="64913" checksum="54E8785AC667BA04" modified="2013-09-18" version="1">MLKIKDFQGMQYSRDTSSQFGQKDYKFFNQQYATTSYQTEHDMNPALIVQPKEDEDVIKAVQWARDNKVSVAVRSGGHQYSGASSTGGKNIQIDLTNTYKDMMVLEEDGVPDDRALVLAGVSNRLQDFNDYLRSVNLFVPHGQCAYVCTGGHGQTGGYGQLGRSFGLFGDHIIKIRLIDHNGSIQNVTKESDSELFYAILGGSPGNFGIITHYTVEVYRASSYMGTVAGPNGFKGPHGLKGLWIYEPKVLSRLLGFIAKMSDEGTAPRGYDLCCSVLSTDFPVTMLFPSLRDDTIWKKIQQKIKTALAKDVLDLLNGSFPAIIVLYAQWCPTNKTDKYDSTVDNWFKQFRDLQNDWSNHTLLINEFDEGMDTMTGKWIFPKRREFELPYVKRTYATKSQTLQKDGWVDAVVKRLDLIYNPHQKLDNDKSDKEGEVYDHCKLSVQIQCFGGKNSRFLLNKDNGTSYSWRDSTVVQTLDCFHDPGAKYREYALGWQKTNDTIMIGAKSPFSKQDRRVLWGSWGDWDMSKPEIWQAYYEDADKYKRLGKARAKADPNGTFTANPFAVTAVRDGTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPL2</accession>
    <name>S0EPL2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to chromate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437391.1">
        <property type="nucleotide sequence ID" value="XM_023570254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPL2"/>
    <dbReference type="STRING" id="1279085.S0EPL2"/>
    <dbReference type="GeneID" id="35404826"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11364"/>
    <dbReference type="HOGENOM" id="CLU_018106_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="483" mass="52079" checksum="D507ACD2060738E9" modified="2013-09-18" version="1">MVVGGWENSLRRAADRALQTLKVNWHLGFTAFGGPPVHFKIFHDKFVTKLQWIDEQIFQELFSVSQALSGPASTKMLYCINLIHGGLFEALLAFFVWSLPGFLGMFGLSIGVSSIGDTLPRAVYALLSGLNAATVGIIALAAVELSDKAITDQATRLVLSITAMAGILYNALWYFPVLIVAGGCCTIVYDFRWLHRPVRAVKNALLRMRMGRVTESENIQGAENGTDGNANDSRVALAETSESGPREDGPRVVPQEYRLNFSWKSGTAVIAVFLLSFIVVLVLRGTLPTPPLLYKLFANLYLAGTIIFGGGPVVIPLLREYVVAEGWVSPRDFLIGLAIVQAFPGPNFNFAVFLGGLAAANSGYPAIAGALIAYLGIFVPGMVLVHGTMGVWGVLRSRRWVKSAVRGINAGAVGLIYTAVYRIWQVGYIDQGFQSGKSLADDPWWVVVTATAFVGGRYFGVAPPLAILLGASMGLLRYGIVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPV4</accession>
    <name>S0EPV4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437851.1">
        <property type="nucleotide sequence ID" value="XM_023570790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPV4"/>
    <dbReference type="GeneID" id="35405306"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11845"/>
    <dbReference type="HOGENOM" id="CLU_2775986_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496265" evidence="1">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="69" mass="7541" checksum="0ADFE47059781FF3" modified="2013-09-18" version="1">MKLIYTALFALAATAVNACDSTLCEGATVLRVVPCTKGCMGRPCHLYDCPDSPYTYICGKDKTKCDEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIC7</accession>
    <name>S0DIC7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to nasopharyngeal carcinoma susceptibility protein LZ16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_01565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424016.1">
        <property type="nucleotide sequence ID" value="XM_023577295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIC7"/>
    <dbReference type="STRING" id="1279085.S0DIC7"/>
    <dbReference type="GeneID" id="35395050"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01565"/>
    <dbReference type="HOGENOM" id="CLU_015602_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="429"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="598"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="656"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT61935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="717" mass="81454" checksum="EF8BBB6302AACB6A" modified="2013-09-18" version="1">MPSRKRSLAAIDGDDGEKEHSLQHRIRNMWQFANLCQWIYIFGKAAKIDEAIDVEEIETECLKPNSSILADIALALLKLVSSHRGLTHEIFDDQARKQFTKKSPNYNPFGSGETPLKFNDFDIFTKIKVMQQLTQWAMIHPERIRDKMEEQKDSEQTSWRIEPYGWDADDRTYFVLDDNRVYRLTEPPMITKPTKAKKSRASYGSRRSSKRRQITLNAEEVVETDQEIKEDTPLEDNGLGGMTWECLAVTLDDVRSVVDGFRKSRDENEKILRNQLEKHLVPILEKQEQSRQRRELQRERELANAAKMANAKRSSRIAGRVEQQRQEEQIREEERHRKEEEASKRREELAQIKMGEERDKRLVSREQRLREREARRVQHEEELAQLSEDSKNLSSNSTRLSERRLQVEIEKNKQALKELEDAEEDWIFDCICGLYGQVDDGAHSVACERCNVWQHSQCVGLSEAAADQPEFHYICASCIRREQDVKRPRPTIKLKLNRPPNSGTQSDPSRSSSHLGLSFSGEDRKVNGTGYGDHDVSNGNVEHSLTPLASTPDTNGNGVGFPISMMNARSEVSKEVLYTPQGTPVIPAPVKLDVSIQGSPPRSTSMTTPMTSFRTPSPSKGIDSFQGDKTAESALSTPQISREIYRAAHEQNGTIPSIAGLSPTKHSPPRPIDSASSNRYKAATPILPPVALSPSPQHQILTPPIKPSEPPRPFENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJA1</accession>
    <name>S0DJA1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424645.1">
        <property type="nucleotide sequence ID" value="XM_023570197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJA1"/>
    <dbReference type="STRING" id="1279085.S0DJA1"/>
    <dbReference type="GeneID" id="35394360"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00875"/>
    <dbReference type="HOGENOM" id="CLU_038421_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="70"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="381" mass="42469" checksum="EFE05DE99101D0E5" modified="2013-09-18" version="1">MAPTQQAAWRKAPTAEEIANRQTVGINKETVTNITSTDYPGHHPGEDLAFTLDRFRDAFSVNFHQNDQFLASFSLVGIDASLANAFRRILLSEIPTLAIENVYIENNTSVIQDEVLAHRLGLIPFKGGREGLHNFLKWHKKPEAGEDPYAGCFDWNTVRLELNVTCTVNEDASPAENDPLKAYHNAHVYARDIVFVPTGKQAEYFSGEDAIAPTNPDILIAKLRPRQTINLAMHMHKGIGSDHAKFSPVATASYRLLPTITITKPILGADAEKFAKCFPKGVIGLEKVTAEEAAQSGSGYDGQEGETKAVVIDAMKDTVSREALRHKEFEDKVKLGRRRDHFIFSIESTGQWDSDELFLESVKHLKLKCKKLEQQVINMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJK3</accession>
    <name>S0DJK3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00688</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424810.1">
        <property type="nucleotide sequence ID" value="XM_023572274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJK3"/>
    <dbReference type="STRING" id="1279085.S0DJK3"/>
    <dbReference type="GeneID" id="35394173"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00688"/>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="240"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="632" mass="70763" checksum="A6E7FC34E8CD985A" modified="2013-09-18" version="1">MSVRYLRQASRPLIHSISQTTSARCSHALSCGNSSRTLQGSQSVTHGRSLATSAARSQDGLEGYSSFKQQRRTELWAEKESEDPLFEETHPRLVHHAERKTVPEFHEAFRDVLDDSKHVSVCGRVRSKRVVGKNLIFLDIVNEFERLQVMLNRSKCMVEEEARSLKFAMFRNLIEVGDHISVVGVPVLTKAGELTLEAKTLPELLSPTMEQIPEKLTDPKTRMQERHVDMLVNRQAIDVLRLRAEITKHMRDYFHSRKFLEFQTPILAENAGGAVARPFVTRATEFKDKDLALRIAPELWLKRLVIGGVDKVFEIGPSFRNEGVDATHNPEFTMCEFYSAYSNLEDLINQTEEILCSLAQHSQDLISTQLTSLPSIDMKQFVRPFKRVEFVPALQEALGLRLPKLSSPDALPELLAILKLAGIKVPGDVPASLAKLLDRLAAVYLEPMSFTEPILIMNHPACMSPLAKSFLCPQTYQLVSARAELFIGGRELANMYEEENDPEEQKRKLLDHRNLVNKDDGSIAIEHNETPEGEAAVEEALDEPFEDENGDAAPLDQSYVKALDYGLPPTGGWGCGVERMVMLFSGANRISDCLSFGSIRNVVGLSAAEESKASPEEYKKLEEDKQSSSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJP2</accession>
    <name>S0DJP2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_00891</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424631.1">
        <property type="nucleotide sequence ID" value="XM_023570019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJP2"/>
    <dbReference type="STRING" id="1279085.S0DJP2"/>
    <dbReference type="GeneID" id="35394376"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00891"/>
    <dbReference type="HOGENOM" id="CLU_033556_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF40">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="14">
        <location>
            <begin position="186"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="13">
        <location>
            <begin position="384"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT62550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="454" mass="51508" checksum="D36EFC9696B9F489" modified="2013-09-18" version="1">MVVISRRTRRRLRSILILILISTFIIYSILPHDSAIRLAFVFNISRFFNFLRGAATNRDAWLWKSPRYAVDLKNEVGYLIKTGYGTRHRVPDQLAAFEATGGFLGKEGESFLVVGDWTTVNQTDAKLIGVTVHDAIKRVMETKVRGKVDDYPRLVKYTSLQAKLQAGDEEEALKIGQSYGWELDALKFIMGMEMIYHQLPGKKWYIILDDDTFLIRPSLELLMGHVDYRKPRYIGNAVGDYKARFGHGGSGILISGEAMRRLFEHPGIVQEAYAESMTETWGDRLVATTLQKLGIYIEESYNHHFNGEPPSITRIWGDRFCSPLLSFHGLRKPGEMRRVGETLAKIDKPVLWHDVWQLFGGSAMSALESRPTELTADHVGKPDEHTRSWGDVRSANACQKRCEQSGRRCLAWTYEMEIERCHTSPWLLLGADGATGKASGVNWPEVKPLLKGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK16</accession>
    <name>S0DK16_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424767.1">
        <property type="nucleotide sequence ID" value="XM_023571729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK16"/>
    <dbReference type="GeneID" id="35394222"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00737"/>
    <dbReference type="HOGENOM" id="CLU_1266971_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="218" mass="23312" checksum="5A37BD88639AE071" modified="2013-09-18" version="1">MAVAKFYHVNISRFVTRRDDPFDGDKGTQENEEEGGSGIAGPSFALDYSMSISQRSLGAVGDTEGNEAGDTPRGWMISLCLCLLSLLPRFSLVPFDPAAVSPTSATTTISLLSTTATTAQLSTNFTMAALPPQKFLPLTPAPKSSFLSLAPATSPSYPQKPAVRSHTRPSPPRRASTESSASSSSSSNNSYRILKLGPVHYGEHADEHKTDFHDVILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK85</accession>
    <name>S0DK85_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor IIA large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_00590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424901.1">
        <property type="nucleotide sequence ID" value="XM_023573124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK85"/>
    <dbReference type="STRING" id="1279085.S0DK85"/>
    <dbReference type="GeneID" id="35394075"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00590"/>
    <dbReference type="HOGENOM" id="CLU_030027_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000006">
        <property type="entry name" value="Transcription factor TFIIA complex subunit Toa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.100:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="175"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="400" mass="44346" checksum="2DC692EFAA1CE192" modified="2013-09-18" version="1">MSNPAVGNVYQAIIDEVVNSSRVDFEESGVEESVLEELRQGWQQKLTQLHVAQFPWDPKPDPPAQAPPPAVPPAQTHAQAQFSPQLSNPTGLSLPGMAQPQVQNGIKPEGNNIKTEPHVPIKQEPGLQGNPMAYQQYNNNTNINMNDNNVAANRAAQQLQAQYGQRAASSINALHQQQGHSQQNQQQQQQQPALPQPHQQQQPGLTQQHQQQQMYRQQMAAATAQQQQQHPANGQPHIQNGQTDGTGDLEDFEGVLMQRAADGNLHELGRVEIDRMLHEQILAKAKSMEGGGLMLPLKEATRTSSAPTSRVVKSKQPATYDGGDDDDEDDEDAINSDLDDPEEDRDDDDVDDEGLGNIMLCMYDKVQRVKNKWKCTLKDGVLTVNGKEYVFHKATGEYEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKL3</accession>
    <name>S0DKL3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to DUF218 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423993.1">
        <property type="nucleotide sequence ID" value="XM_023577018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKL3"/>
    <dbReference type="STRING" id="1279085.S0DKL3"/>
    <dbReference type="GeneID" id="35395075"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01590"/>
    <dbReference type="HOGENOM" id="CLU_084257_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3620.10">
        <property type="entry name" value="YdcF like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="320" mass="34768" checksum="4878D5C7887F5D25" modified="2013-09-18" version="1">MAISPDKVSKAADAANIISEFVAHEQVCALSDLQRALFGFSATKKQPNAKTSSNSVAVVVLCGSAILSIVDTVVSSVTKLVEATDEAVVLVITGGIGHSTQLLYDAVARHPKYSRITGQVQGQPEARVFQTIVERFFHLEVEQNNLITTGKHPTQKLTILIEDASTNCALNAVYTRKILDQHGYTSPCSIVVAQDPTMCRRTVAAFEQVYSDKTDGTPVFAGWPTFVPKVAVQDSGAQNQASGLTSYLRYGIADFDKNQNDGLWSMQRLMSLLVGEIPRMRDNENGYGPRGKGSIVHVDIPQDVEDAWIVLGDILGQKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKM8</accession>
    <name>S0DKM8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to novobiocin biosynthesis protein novR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425032.1">
        <property type="nucleotide sequence ID" value="XM_023573287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKM8"/>
    <dbReference type="STRING" id="1279085.S0DKM8"/>
    <dbReference type="GeneID" id="35393929"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00444"/>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="104"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="340" mass="37305" checksum="69F7AA41B15AA870" modified="2013-09-18" version="1">MLSSKSFRAAPLKRVISRQASLSFSSSASRPRLILPSQKLTTKPYSKVQPSLRSAFFATSSEASVAAPEEPVNQNFAAVATGGIPYPGIPKIEDPYQKRQWQLEHMAGAFRVFARMGFTEGAAGHISVRDPVDPSTFWINPMGVHFGMLEAGHMVHINEDGQVIGGNRVAVNAAGFTIHAAIHKARPDVDAACHAHSKYGKAWSTFGKPLEMISQDACIFYNDHSVYSDFGGVVFEDDEGARIAKALGPKNRSVILQNHGLLTAGKTVDEAAYLFSLMERTCEIQLLVESAGLPRQIIGDEEAEYTYRYNADPEALYTEFQPDFEYEVWKSNGKLKSGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKW7</accession>
    <name>S0DKW7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425350.1">
        <property type="nucleotide sequence ID" value="XM_023573670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKW7"/>
    <dbReference type="STRING" id="1279085.S0DKW7"/>
    <dbReference type="GeneID" id="35393585"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00100"/>
    <dbReference type="HOGENOM" id="CLU_102612_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18063" checksum="3F72A9196854BEEC" modified="2013-09-18" version="1">MGIRDFFDSRFFEHSWKNKVFILQVVTVTIAFILGIAKVATKPSGIPMTRSDIMAITMSLKTYAFLAYEYVTQKVDKFKRFGSLKANAILNTMDIVFWAVVMGLAFNMATQVCIGANCAIGILVGLVALVVTIVNFWAAVIAWKDHKYFKRNGVRRGHGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLL1</accession>
    <name>S0DLL1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425580.1">
        <property type="nucleotide sequence ID" value="XM_023571641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLL1"/>
    <dbReference type="STRING" id="1279085.S0DLL1"/>
    <dbReference type="GeneID" id="35394230"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00745"/>
    <dbReference type="HOGENOM" id="CLU_007504_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="703" mass="79047" checksum="F842390BFB1A4A2F" modified="2013-09-18" version="1">MKPLSENSLPYTESDNSARDTRHGRNTTSSSISCHSDPFGTSGIEVEDGVQLRDFSSPGPVMSRCMSPDPTRFVAERPSRLNNEDAGLAVPKINEPLSDDYAHSEWETVAGEDACEIHAESSTRPLKRRGNFNFGNKQQAQSQPNQNLWVPQTHNFELVSPGDPSVRNVPRSAPHLHSFHSSSSFYSESLRNKDPDTCVPCDPEDYPQNNHMYSRASSDSDEDPFKYDTDAYSGFLRSSAERENVDEEVKVPVHREEKAIRRVPVPDRRLQGEISSLVKNRPLTGTEGDWQTVTTEHAFDSMQQDYHDSIAKGTGSSVADVSDVTERELHPRSYGSRDRIIRHPSGNNKYGSYRVRTDRGTKLPVSVPQYGEGPGTYASNTTRNFSQAKSRLPESAARFSNLFRREPSEQTRFQESNSDKPAHVPHDDFLSKIPRLPFPLVSLPEAAMLQQFKRQRGEEDHSQSAGNFGVRGRSNTISTANSPPLPKTPSPPKRSFWPSSTSGDVTRPARILHLHRLPQAHRPRDSNDRVTDMLVSSSAILDTPPPTDPKSSTHRVWYRNFQPSISTCRTGAHTPGFSTSVNSRRVGHCQSEFDPLADSPFTQREARLIEEARKDIRIHRRHADMVAQRGKQMFMWVMILTLFFPFIGPIVLYGKLNSTISWYTHGEMQCLTKDQRGTLKQQLLVEAVVYPAIIIALSVHYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLN8</accession>
    <name>S0DLN8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to Protein indc11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423539.1">
        <property type="nucleotide sequence ID" value="XM_023574117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLN8"/>
    <dbReference type="STRING" id="1279085.S0DLN8"/>
    <dbReference type="GeneID" id="35395548"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02065"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08273">
        <property type="entry name" value="MDR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="337" mass="36894" checksum="E30E0FBE7F84C8AC" modified="2013-09-18" version="1">MSNRYRKVVIPRYGDASVLEIVEDTLAAPASRHVQVAPIHAGFSGADVHMRRGVYPSQQKPPFTPGYCLVGTVKANGTNSNIFKPGDIVACLTKYDAQAELVNLPEKHLIPVPAGLDLQQVTALVLDWSTAYAMVHQVAKVKSGQKVFVHGVSGSVGYATMKLAQLRGAKVYGTASERNHAAIREQGGVPFVYTDKNWIKVMKDGGGVDAAFDSIGFDSFEESYDILNDHGIVVGFGANQLSLTGEAPISAIWPTVKFLLKGRVPWRSKRTYFYRIDRDQPEYRPNMNTLLDLLGKGEIHVPIRKVWDLDDIQEAHRQWHSGSGVGAVIVNIRSGAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-09-07" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLP2</accession>
    <name>APF1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Apicidin F synthase</fullName>
            <ecNumber evidence="8">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Apicidin F synthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-ribosomal peptide synthetase apf1</fullName>
            <shortName evidence="6">NRPS apf1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">apf1</name>
        <name type="ORF">FFUJ_00003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="J. Nat. Prod." volume="76" first="2136" last="2140">
            <title>Structure elucidation and antimalarial activity of apicidin F: an apicidin-like compound produced by Fusarium fujikuroi.</title>
            <authorList>
                <person name="von Bargen K.W."/>
                <person name="Niehaus E.M."/>
                <person name="Bergander K."/>
                <person name="Brun R."/>
                <person name="Tudzynski B."/>
                <person name="Humpf H.U."/>
            </authorList>
            <dbReference type="PubMed" id="24195442"/>
            <dbReference type="DOI" id="10.1021/np4006053"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E103336" last="E103336">
            <title>Apicidin F: characterization and genetic manipulation of a new secondary metabolite gene cluster in the rice pathogen Fusarium fujikuroi.</title>
            <authorList>
                <person name="Niehaus E.M."/>
                <person name="Janevska S."/>
                <person name="von Bargen K.W."/>
                <person name="Sieber C.M."/>
                <person name="Harrer H."/>
                <person name="Humpf H.U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="25058475"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0103336"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Non-ribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF) (PubMed:25058475). The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L-phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L-2-aminooctanedioic acid (PubMed:25058475). L-Phenylalanine is the only proteinogenic amino acid directly used by apf1 (PubMed:24195442, PubMed:25058475). The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster (PubMed:25058475). Lysine is converted to delta-1-pyrroline-5-carboxylate (P5C) which is reduced to L-pipecolic acid (L-pip) by apf3 (PubMed:25058475). L-pip is epimerized to D-pip, probably by apf1 activity, prior to incorporation (PubMed:25058475). L-Tryptophan is N-oxidyzed by one of the cytochrome P450 monooxygenases (apf7 or apf8), and further methylated at the hydroxy group by the O-methyltransferase apf6 to yield N-methoxy-L-tryptophan (PubMed:25058475). The synthesis of the fourth apf1 substrate is more complex (PubMed:25058475). The fatty acid synthase apf5 is involved in the synthesis of the octanoic acid backbone of L-2-aminooctanedioic acid by fixing one acetyl-CoA unit and three malonyl-CoA units (PubMed:25058475). Then one of the cytochrome P450 monooxygenases (apf7 or apf8) may oxidize this backbone to 2-oxooctanoic acid (PubMed:25058475). The aminotransferase apf4 is predicted to catalyze the exchange of the keto group with an amino group (PubMed:25058475). The next step would be the oxidation of 2-aminooctanoic acid by one of the cytochrome P450 monooxygenases (apf7 or apf8). The last step is the oxidation of 2-amino-8-hydroxyoctanoic acid to 2-aminooctanedioic acid is catalyzed by the FAD-dependent monooxygenase apf9 (PubMed:25058475).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is positively regulated by the apicidin F cluster-specific transcription factor apf2 that binds to the eight-base-pair motif 5'-TGACGTGA-3' called the 'Api-box' that is found in all promoters of the apicidin F cluster except in the promoter region of apf2 itself (PubMed:25058475).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Leads to the loss of apicidin F production (PubMed:25058475).</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="4">Apicidin F, like the other known apicidins, is a cyclic tetrapeptides with anti-malarial properties via histone deacetylase inhibitory activity (PubMed:24195442).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="8"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="S0DLP2"/>
    <dbReference type="STRING" id="1279085.S0DLP2"/>
    <dbReference type="EnsemblFungi" id="CCT63360">
        <property type="protein sequence ID" value="CCT63360"/>
        <property type="gene ID" value="FFUJ_00003"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00003"/>
    <dbReference type="HOGENOM" id="CLU_000022_60_0_1"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-19327"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000437156" description="Apicidin F synthase">
        <location>
            <begin position="1"/>
            <end position="5084"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 1" evidence="2">
        <location>
            <begin position="731"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 2" evidence="2">
        <location>
            <begin position="2341"/>
            <end position="2415"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 3" evidence="2">
        <location>
            <begin position="3463"/>
            <end position="3539"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 4" evidence="2">
        <location>
            <begin position="4554"/>
            <end position="4631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation 1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 1" evidence="1">
        <location>
            <begin position="822"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 2" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation 2" evidence="1">
        <location>
            <begin position="1788"/>
            <end position="2192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2415"/>
            <end position="2441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 3" evidence="1">
        <location>
            <begin position="2478"/>
            <end position="2755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation 3" evidence="1">
        <location>
            <begin position="2935"/>
            <end position="3328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 4" evidence="1">
        <location>
            <begin position="3581"/>
            <end position="3866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation 4" evidence="1">
        <location>
            <begin position="4029"/>
            <end position="4426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 5" evidence="1">
        <location>
            <begin position="4669"/>
            <end position="4948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2421"/>
            <end position="2437"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="768"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="2376"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="3500"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="4592"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="24195442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="25058475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="25058475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="25058475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT63360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="5084" mass="562186" checksum="DBCE0E79CE257757" modified="2013-09-18" version="1">[encoded data, 5084 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLT4</accession>
    <name>S0DLT4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_05299</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425640.1">
        <property type="nucleotide sequence ID" value="XM_023571313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLT4"/>
    <dbReference type="STRING" id="1279085.S0DLT4"/>
    <dbReference type="GeneID" id="35398780"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05299"/>
    <dbReference type="HOGENOM" id="CLU_008515_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="356"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="430"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="591"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="643"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT63559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="779" mass="84284" checksum="3F0301BBED72919C" modified="2013-09-18" version="1">MASPEGDGNTGATASDSQPQGEGQRNRGRGRGKGNQNRRGGQRRGRGGNNSNVPNVPANPAAQDVAAAASRAHAMAAGKAAEAADDDDGEVCFICANPVAHHSIAPCNHTTCHICGLRMRALYKTKDCAHCRTPAPYVIFTDDPEKRFEDYSEKDITTTDSNIGIKYTKEDIVGDTVLLLRYNCPDASCDFAGLGWPDLHRHVKSAHRKRMCDLCTRNKRVFTHEHELFADKELEKHMRHGDDKPGAADQTGFKGHPLCGFCGERFYDDDKLYEHCRMKHERCFICDRRDSRHPHYYLDYNALEEHFKKDHYLCSDRECLEKKFVVFESELDLQAHQLSDHGGKATGRDARVVNISGFDIRTPYQQERGGGGSGREEGRRGGRDGRRGGNRGRDPNMEPVPASSAQPLRRDEIAFQRQMAIHSAQSVSNRTFGGSLSAPSPTPAQASSQSRGGSSSNTPRASQTNLANPIESATVPDPANLSPEERARLVRHGAVVERASNLLGNDAQRMATFRNHISSYRQGGLTAPQLIDAFFTLFADTSSNALGTMVREVADLYEDKNKADALRKAWQDWRAINEDYPSLPGLSGMHGATSSSSGWANAASANPAVPNAKATQKYSNRVLKLKNSTRLGGPAPVSSSGTSSWAARPAVSAPPSSSNAFPSLPSAGNSSSSAPRSNWTTPTPSSSQSTTLNRPRPAPRPTGEDAFPALPTAPKPTTTIFGYGNGRAVRRDYGSRETGFQWGGSGSNTPGGEEPAEDDEAGGKKKGGKKGKKVLVQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLU9</accession>
    <name>S0DLU9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425497.1">
        <property type="nucleotide sequence ID" value="XM_023580872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLU9"/>
    <dbReference type="GeneID" id="35394730"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01245"/>
    <dbReference type="HOGENOM" id="CLU_034112_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="576" mass="63226" checksum="42A46BDDD5C4F07E" modified="2013-09-18" version="1">MSSSEASGLEKTQPAGRRPCPKTLYDYDRMSCKEREDLQERTRMGHYSILRALVRKRGPGEPTLEEELQAQNPKRRKADYEESDSSESSSRSEESDEDEEDDKGDQQDDSDDRVTHQPRYTHHSRPDIEDTGDSPVVDDPFTLKPDNELKELRDILRKQQSEINELRTKQHSDVALLRESLLKGKTNASQTVAATSTILNELRKDLDRQTRLLSWNTQESLQYVTKVQMEEFVKRAVEEVLDKFHLDEKIKDAVIAQFDEERSRSVVLPTESAKSHLILPVSGIVVSSGTENDHRLDAPENDSNIGRDDAPLQSNRRIGSPTAFENNAHSVIRGKGPEDERPVTPRPPAVTSGNLNIANATSTNAFDSAEGGVIIPKLEPSRLLKDTAKTDSLLTTPARQTARGGSPFPYGYAPKKYERATIPPYGPSQPLNITTETDSLPVTPIRQTTRSASPFTSGSVPGTNGKPRIPSFGLSQPLNTTTETDSLPATPTRQTTRSASGSIPGTKGKPRIPSFGLSLPTNTSTETDSLPAAPTGQTTRGAGSFPGGYTAIRRSVLSSTPSTSRRGQCTQGKKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM31</accession>
    <name>S0DM31_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425572.1">
        <property type="nucleotide sequence ID" value="XM_023580439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM31"/>
    <dbReference type="STRING" id="1279085.S0DM31"/>
    <dbReference type="GeneID" id="35394769"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01284"/>
    <dbReference type="HOGENOM" id="CLU_032410_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="420" mass="47597" checksum="792ED56B5B6AF6AB" modified="2013-09-18" version="1">MATGVDARLLKSTRFPPEFSQKVDMQKVNLQVMKKWIASKISDILGSEDDVVIELVFNLIEGPRYPDIKSLQIQLTGFLDKDTAVFCKDLWKLLLSAQSSPQGVPKELLEAKKLELIQEKIEADRAAETAKQRRDDWDRRDREVADLKDRDRRDRAAARGDTWQGRRGDQGASGGEVAGQDRPALTSVIPGTHMDAIVTFHEEDVVVDAPTKADENRPLDHVRHRHRPGRAQEVAVPPEALINRIKRQRPVSHGEQADTRKRSRSPRGDTYRGRANKRTERGRPGRPSRSLSSERNSPAPKRRRYSPSRSRSVTRRRRPARDISSSRSERTSDSRSRSRSHSYSRSRSRSSSASPDRRTKRRPNHGRGQQPSRQRDSPKGRRRNSSSASSRSRIRENSADVSEDGSRALPTKPEAEVPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM86</accession>
    <name>S0DM86_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_01855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423749.1">
        <property type="nucleotide sequence ID" value="XM_023574084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM86"/>
    <dbReference type="GeneID" id="35395338"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01855"/>
    <dbReference type="HOGENOM" id="CLU_110806_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT61668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="144" mass="16546" checksum="FDC676D5D9BAB045" modified="2013-09-18" version="1">MLPQCSWLPLLFIPTNASPAFIFLFFICTYFLNRPCVYCSILLLILFLTSCNWSDRCFFDLGSNWFLPRPITPDVAFTSPSEDLTFNSTVLDMANTTVAAIIKSASDDLAARRAEWSGLGIEWLRNLLGKREWRIDCMDIYIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMJ1</accession>
    <name>S0DMJ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to UBX5-UBX (Ubiquitin regulatory X) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425727.1">
        <property type="nucleotide sequence ID" value="XM_023571420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMJ1"/>
    <dbReference type="STRING" id="1279085.S0DMJ1"/>
    <dbReference type="GeneID" id="35398684"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05203"/>
    <dbReference type="HOGENOM" id="CLU_021255_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="452"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="534" mass="59267" checksum="5DF9FAF469BABA22" modified="2013-09-18" version="1">MDDNISTFMSITGTSTDVARSFLEMTAGNFERAIGLFFENPDLVSGVGAGLSSTDQPAAAPATTSATRGNIGRQDSAGVIHIDSDDDQDMQIEDFSDNDDDNERAVAAQAAALAQEEEDMAMAKRLQEELYQGNQGSGSGGNPDDVRAPIARTTETLVAPGWGGGGEHDDGMEAAFLEELRRRRRANPPNRAGGPFSQQIWADPERRSAQTAENGAHARRLEDLFRPPYDLMARMSWDDARTLGKEDKKWILVNLQDMNDFNCQALNRDIWKDEAIKSLVSENFIFLQYDKDFPDAEEFVTFYFPNQTHENPDNYPHVSIIDPRTGEQVKVWTGRPFPSAQEFHAELAEFLDRYSLAANSKNPVAKTTARKPQRVDVDRMTEDEMLEMALKNSLEGATGSGGSSTPNLHDPDALTKESDPEEGKGKEPEAPVEQSPWAQISSTTPHTEPEADPTTTTRIQFRHSTGRIIRRFNLNDPVRRIYEWLKSEALEGKEGVEFELKKMPAGQDLIESLDTTVADAGLKQGTVMIEYIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNG6</accession>
    <name>S0DNG6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to E.coli tetracycline resistance protein TCR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426200.1">
        <property type="nucleotide sequence ID" value="XM_023571987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNG6"/>
    <dbReference type="GeneID" id="35398178"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04697"/>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="18"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="529" mass="57629" checksum="151B8B217FDCB323" modified="2013-09-18" version="1">MGMLRAGPRDPDAFPAMQLFLLAIVRLAEPIALTSLFPYAWALVKSFEIGREEDASFYSGILISAFSLAEAVMGTYWGALSDRIGRKPVLIIGSLGTMISMLMVGVAPSFGVALFGRLLGGLLNGNIGVIQTMVGELVTKPEHEPRAYSIMPFVWSIGTIVGPSIGGMFANPHDSWPESFPIGSLFQRQPYLLPNVICAGLLLVSIVLGFLLLEETHPDMVQHVPTSEYHVSEETPLMMNNRMATEIEPRAYGAIETIEDSTDGSIGDWDTLCIENEKTAAASIKIWNCRVVGFIVALSIFTYHSMTFDHLLPIFFEDSRVDAVEMFKHGSIFPFSSPGGLGMTPRDVGVILAIDGGIALFIQVFVFPWTVKMLGTYRLFLLVTVLHPIIYVLMPMLLLVPDGLLYPAIYGCLIIRNILSIILYPLLMILIKEATPAPSALGKVNGLAASAGAACRMIASPVAGFLWTVGTKSNCSALPWYGSAIVAILGAVQCFSVPRRRNEEPYEETSKAPNKQTVTVTETEFYDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNL5</accession>
    <name>S0DNL5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_04630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426255.1">
        <property type="nucleotide sequence ID" value="XM_023572061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNL5"/>
    <dbReference type="STRING" id="1279085.S0DNL5"/>
    <dbReference type="GeneID" id="35398111"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04630"/>
    <dbReference type="HOGENOM" id="CLU_017099_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="65"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="685"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT64174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="761" mass="86148" checksum="14B13A9D3BE00271" modified="2013-09-18" version="1">MGDWARGWTRVGQTGPTQHYGRVWEAERELQELSIIESWNDDDSWPGINKPLFNGPDAKRFDTKLAKLEDLGYGAFGRVEKISYGSVCLARKRIPRRRGFTIDDLRKESLTMQKLDHRHVVKLVATYAPRAHELCLLIWPAAVCNLSTLLEDLEYLRMGEGDREDILERLDALDIKDLSAIEQSSEDQLLHSTTKCPLEFLRNTIGCIARALAYCHQNDVRHLDIKPSNILLKADRVYLADFGVSRDVSGQDQTMTEGVPGTERWRAPELYANNGSSMQLSDIYSLGLVFLNIATVLYNVRLSEFDEALRYPSRNTQEEQLREREQKLNAHLEKLTSHALVTPPFMFTYEGQETVRPRPVVNLIARMITPNPKNRLHAYKIDDKLSMLGGIHQIYHGECCKRPISWVEDKWDKKLTTLTSLRKENDHLKQKVAELEGRDRTYESRVQREVDEHKQAAVLLQKKLKDMEDRCHMLEADNAKRRSSASKPSSKMAMPRPYRSSTTNLESGPGLESSPKSKSTPVTPAARPAFQPWSRSYQRLPPEQRASPLQRQRVSPRPPNDITPRGSIEFPTSRSPSFTNISGYALRSRGSGSKLPLPITPSRSETPNLNRDQSLTDSSMSSSVFSRHSIETNPTPLQSSPALDRNPLPMDSAKGPQWGQLSRQPDQPDARVVTPEPQPAPSEPSSPAFSMPFSTMSSPRTLRSDLASIDRDQTRRPSVPSLQSLKSWAEVANEGKKTLKMITRPRAHSNRSNRQLEAEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP29</accession>
    <name>S0DP29_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to asparagine synthases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_01126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424414.1">
        <property type="nucleotide sequence ID" value="XM_023582205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP29"/>
    <dbReference type="STRING" id="1279085.S0DP29"/>
    <dbReference type="GeneID" id="35394611"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01126"/>
    <dbReference type="HOGENOM" id="CLU_012368_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03766">
        <property type="entry name" value="Gn_AT_II_novel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="538" mass="59073" checksum="E21755EC6EAE6E17" modified="2013-09-18" version="1">MCGIHAIISSSPEQALSSVPERCLVNRGPDHTGTVRIQLDDLFLTFTSTVLSLRGDHVAKQPLVDHVTGSILCWNGEAWGIQGESVQGNDGEAILALLAEASRGAGDVLGILRAIEGPFAFIYLDKPAKRLYYGRDRLGRRSLLVRDGSPFVLSSIAETPVDGWTEVEADGCYTLDLPTGDSPEGLVPDRHDWTADTTLISSIGRFNEDLPQENFALGQDSRSVQELRSRLVESLRLRVLDVPLPPKAKPTDARVAVLFSGGLDCTVLARLSHDMIPADQCIDLINVAFENPRIAGQFKDLSREELYERCPDRMTGRNAFAELSRVCPGRLWRFVAVNVPYAENLEHRAGIIRLIYPHNTEMDLSIACALYFAARGQGLGEATGGSNPQPYSTTARVLLSGLGADELFGGYGRHGVAYTHRGYGGVVQELKLDVSRLGKRNLGRDDRVMAHWGREVRFPYLDERFVKWAIEAPVWEKCDFETPGGEGRLDAEKRVLRLVAQSLGMSSVSKEKKRAIQFGARTAKMESGKVKGTTVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPD2</accession>
    <name>S0DPD2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable AFG1-ATPase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426377.1">
        <property type="nucleotide sequence ID" value="XM_023572212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPD2"/>
    <dbReference type="STRING" id="1279085.S0DPD2"/>
    <dbReference type="GeneID" id="35397977"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04496"/>
    <dbReference type="HOGENOM" id="CLU_008681_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT64296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="539" mass="60926" checksum="7647593CC6C7AB73" modified="2013-09-18" version="1">MRGALRCSATARHPRLLRPSADGGRFARTLRTSATPQGLRTGLYCRQTQQALTVQGANLSTSCFNRSRSMATVVDAEPIHGGGPIPEYDRRVQAGKLRNDEHQRGIIQNFQNLYHELEKYDAPPVQHPSIESLKPTKKSIFSSLFGAGGSRSATGDIPNDLPRGLYLYGDVGCGKTMLMDLLYQTLPPSVKSKNRIHFNNFMQDVHKRLHRFKMEHGNDIDGVPYIAADIAQQANVLCFDEFQCTDVADAMILRRLLESLMANGVVLVTTSNRHPDELYKNGVQRESFIPAIELLKNRLHVINLDSPTDYRKIPRPPSGVYHTSLDSHAHAHAEKWFRFLGDPEQPEPRPETQKVWGREIYVPRVSGRAAWFTFDELIRQPKSAADFIELVRAYEAFIVTDIPAMTHQQRDLARRFITFIDVVYEGNAKLVLTAEKPLSELFVSRDEIAESLMKQGVKHEHAEDAAAKHDLVHSVDKLKDSNLFASSEEAFAFARALSRLRHMESKEWVERGMGLEAQGGKLDKDNWTKARSRQMEDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPQ5</accession>
    <name>S0DPQ5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_00908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424614.1">
        <property type="nucleotide sequence ID" value="XM_023569829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPQ5"/>
    <dbReference type="GeneID" id="35394393"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00908"/>
    <dbReference type="HOGENOM" id="CLU_1299812_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="148"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT62533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="212" mass="23194" checksum="C95249A0EBE97CF4" modified="2013-09-18" version="1">MTANQSGRSSDMNTANSSSNWKVDRRTRDIEIRHHTGVKGKTGAFARRNLTHGYQITGAKHPIFVGPIVPREPPNDLASLCEMKKINCNAPISICYDKFKQDNACPNPAMTTGLNNALAPNINHGCPGCAQATFIVAETYDITLTLEKDVTAGEEILIDFSQARSRLRCSLCHTKESLNGNGGNANSKNFSQNLTRTTYSGPPNVWNDVIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPX3</accession>
    <name>S0DPX3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426680.1">
        <property type="nucleotide sequence ID" value="XM_023572583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPX3"/>
    <dbReference type="GeneID" id="35397645"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04164"/>
    <dbReference type="HOGENOM" id="CLU_061850_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="281" mass="29730" checksum="0FBD3CFB08BA1854" modified="2013-09-18" version="1">MNPSDVPDEPPPSYAESQNQHKKLPAQPPPAAAAAAPPKASSSASQAPPPPPTAGPSQPPAVPRQFPPAFNLYYQGWPNNSYTLAEHQNHPLYLYSAHSGLSDLPPILLHSGPGPSYSPLASASFMFMSASFEVELPPVPGSGAPLAREVVEPVGSHSGLGTGYSFAIEVGPGGNGPRERFEWRRSRGDVIASLGGHYYGWKLVRMSRGAPGGGNMAFAPGGFKDSQGNEVVAAWTMGDGRSLTKVAHFRFMGTGLTGLLGERWAIMVVITGLALFHRDRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-03-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQI7</accession>
    <accession>E0WDF6</accession>
    <name>LAEA_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secondary metabolism regulator LAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Methyltransferase LAE1</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Velvet complex subunit LAE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LAE1</name>
        <name type="ORF">FFUJ_00592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2010" name="Mol. Microbiol." volume="77" first="972" last="994">
            <title>FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Brown D.W."/>
                <person name="Kleigrewe K."/>
                <person name="Bok J.W."/>
                <person name="Keller N.P."/>
                <person name="Humpf H.U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="20572938"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2010.07263.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>INDUCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH VEL1/VEA</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="Appl. Microbiol. Biotechnol." volume="98" first="1749" last="1762">
            <title>Characterization of the fusaric acid gene cluster in Fusarium fujikuroi.</title>
            <authorList>
                <person name="Niehaus E.M."/>
                <person name="von Bargen K.W."/>
                <person name="Espino J.J."/>
                <person name="Pfannmueller A."/>
                <person name="Humpf H.U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="24389666"/>
            <dbReference type="DOI" id="10.1007/s00253-013-5453-1"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 3">Methyltransferase that performs automethylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:20572938). Controls the expression of the gibberellins gene clusters, but does not affect bikaverin production (PubMed:20572938). Controls the expression of the fusaric acid gene cluster (PubMed:24389666). Acts as a virulence factors during infection, most likely through activation of gibberellins biosynthesis (PubMed:20572938).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-methionyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-methionyl-[protein] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:15592"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:142742"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:60561"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the heterotrimeric velvet complex composed of LAE1, VEL1 and VEL2; VEL1 acting as a bridging protein between LAE1 and VEL2 (By similarity). Interacts with VEL1 (PubMed:20572938).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Expression is regulated by the VEL1 (PubMed:20572938).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2 3">Reduces gibberellins production and subsequent virulence during infection (PubMed:20572938). Reduces both the fusaric acid gene cluster expression and production of fusaric acid (PubMed:24389666).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CCT62818" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="FN548141">
        <property type="protein sequence ID" value="CBE54370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62818.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQI7"/>
    <dbReference type="SMR" id="S0DQI7"/>
    <dbReference type="STRING" id="1279085.S0DQI7"/>
    <dbReference type="EnsemblFungi" id="CCT62818">
        <property type="protein sequence ID" value="CCT62818"/>
        <property type="gene ID" value="FFUJ_00592"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000435749" description="Secondary metabolism regulator LAE1">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="C8VQG9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="20572938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="24389666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="20572938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT62818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="316" mass="36624" checksum="4657FCFE4FFDB2DA" modified="2016-03-16" version="2">MVVMPPQNSVNESEGRYLQDGFWQHGRFYGSWKPGKYLFPIDSEELNRLDIFHKVFLLARDNKPFLAPIRRTSPRIMDIGTGTGIWAINVAEECLSDAQIMAVDLNQIQPALIPPGFMPKQYDIEEPSWGPLLADCDLIHMRMLLGSIQTDLWPQVYHNAFEHLTPGIGFLEHIEVDWIPRCDDDERPANSAFVKWAELFLDGMDRFNRSVRVIPQEHRQMLEATGFTDVKQEVIKAYVCPWSADRNEREIARWFNIGLSHSLEAMSLKPLIEKLGFEAEDVRELCERAKRETCVLRYHTYCNIHVWTARKPGPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQM3</accession>
    <name>S0DQM3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to P. aeruginosa hyuA and hyuB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_03865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426955.1">
        <property type="nucleotide sequence ID" value="XM_023572915.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DQM3"/>
    <dbReference type="GeneID" id="35397346"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03865"/>
    <dbReference type="HOGENOM" id="CLU_002157_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF9">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="239"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="542"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="734"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT64874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1306" mass="140553" checksum="2C58D26D90384704" modified="2013-09-18" version="1">MSSQGIRIAIDRGGTFTDAWAEVPGRQEHIVFKILSVCPDEYDDAPTECIRQILEIALDTTIPKGSLLDLAPIESIRMGTTVATNALLERKGDRVAFLATKGFRDVLLIGNQARPDLFDLSVRRLKQLYETVVEIDERVTIEGASEAPSNGPIDVSSDPALVVGQTGEVVRIMKKPDLEVVRADLEELKAQGFKNLAIGLMHSYTYPDHELQVTKLAEEMGFKVSASSVLQSMAKYVPRSQSAVADAYLTPMTFAYLDGFRKNFKGQLEDESANKLLICQSDGGLTSWSKFTGLRGVLSGPAGGVVGLSRTCYDDADGTPVLGFDMGGTSTDVARYSGALEHIFENTLAEVTIQTPQLDINTVAAGGGSILSWENGLLKVGPSSAGANPGPACYGRGGPLTVTDANFLLGRIIPDFFPRRLDRDVVRDKFAALTEIVNKEKEGGEPFTPETLALGFLAIANATMTRPIRTLSEGRGYGASSHNLGSFGGAGGQHAVFIARDLGIKRAIIPCYSSILSAYGMALADVVVENQEPSAITFSEEVVPEIKARLESLSSKGAQGLESQGFDAKTTEHEYFLNMRYQGSDTSLMIPVSENVGDAGVAFTARHTQEFGFSQSRNILIDDVRVRSVGKSRVLNISSPFEELKKYQSDGLTPVPTPIFSRKIFFENHGWTETPVYELKSMSPGVHITGPAMIIDKTQTIVVDHLSKGVILPEHVILEVDKAEKQNVATETVDPVTLSVFGHRFMTVAEQMGHTMEKTSISVNIKERLDYSCAIFSADGGLVANAPHVPSHLGSMSTAIAYQAQRYKAGELKPGDVIISNHPQAGGTHLPDITTITPVFDDEENPKEIIFFVANRGHHADIGGIVPGSMPPNSTELWQEGAAIESFKMINEGAFDEAGLIKRLYDEPASFPGCSGTRTLTENIADLKAAVASNQKGIELIRALIKEFTWPVVQLYMHAIQDNAAQSVRDLLKQFAAKHEGGVLEATEYNDDGIPFKLKVTIDKETGDAVFDFTGTGPEHSGNLNAPPTCSYSVIMYCLRSMISKGDIPLNQGCLKPIKVICPDNTILSPSPTAATVGCTTETSQKIADLVLRAFNAAAASQGTMNNLSFGCGGTDPVTGEVTKGFGYYETICGGAGAGLGWHGASAVHTHMTNTRITDPEILEKRYPVILHEFSIRKGSGGAGKWRGGDGCVREMEFRMPLQVSVLTDRRVTAPYGLEGGEEGQRGQNIWVRKDPVTGAMRQVSLGPRKTSHFAAGDRIIILTPGGGGYGSALETKDEVAVPERDSRSFLTNGSLGVRHSIATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR05</accession>
    <name>S0DR05_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to alpha-1,3-mannosyltransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_03863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426957.1">
        <property type="nucleotide sequence ID" value="XM_023572917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR05"/>
    <dbReference type="STRING" id="1279085.S0DR05"/>
    <dbReference type="GeneID" id="35397344"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03863"/>
    <dbReference type="HOGENOM" id="CLU_030430_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT64876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="511" mass="57669" checksum="5A653F596C9A4357" modified="2013-09-18" version="1">MLTMPSLRLSARSIQITAAIASIWLFVGVLYHYRDVSFYTPSNNFQSTTKPISNSRGVESIKLGARYFLDYPLKDEPKAIFGQLGQRTELLRSWIEELEGRDDSHETAELVGQIVEKQFPWLNSKQGVSPPLADIYDRLGLSYKSKSVKGEKAPAGIVIPTGEKTLRFACHLIAALTRVHKTTLPIQVVYAGDDDLSAAGRQKIQEAANGVKIEMLDVLTVFDDSTLKLADGGWAIKPFAALASRFEQVILLDADAVFFQDPRRLLRQDRFKETGVLLFHDRLLWKNGFADRQDWWHDQIKHPSPETEKSLVWTERYSEEGDSGIVVVDKSRLDVLLALLHIGWQNSERVRNEVTYKITYGDKESWWIGFEATGSKYAFSPHYGGIVGWLGPTKAELDAAKKAKEEKKKVEKKREDKDEVRVCSFVIAHVDQSEKLLWYNGGLLKNKAVNQTEFEVPTHWMIDQTWHKGGSKKAMSCMVGTKASALTIGEKDVLAKSIQAAKDMDEKLHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRI7</accession>
    <name>S0DRI7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to G protein coupled receptor like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_04811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426093.1">
        <property type="nucleotide sequence ID" value="XM_023571857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRI7"/>
    <dbReference type="STRING" id="1279085.S0DRI7"/>
    <dbReference type="GeneID" id="35398292"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04811"/>
    <dbReference type="HOGENOM" id="CLU_024810_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT64012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="488" mass="55213" checksum="7B7D7E53DB0F4868" modified="2013-09-18" version="1">MEGHPEHHRGPNFSPEHIEILITIERVGAGCSMIAIILVLLTFGFFKKLRTTPNLFLIFASIANAGASVASMIGYDGLERGEGSHLCQAQAFIFEWFMQSDPWWSLAMAINVFLVFFCNADPRMFRKYAWLYCLICFGGPFIPAVVLISIRNSPEGLIFGDATLWCWIGTDWSLVRLYAYYIPIWIFSFLSIMIYIAVGYHVFHTRNQIRHMVMDVVGNIEKNDHIPYSSSEHRGSSEAVASPPDASEAGQADFCPQNLTPRQEFYGTAVTEVQITREEPRQVIQQETTLPSPPLAAMPPRIQSWALPSSFKHIERSTSSRAQRFETLCTSDSSRQPPFSVMTKLRAVKSNASMKLRQFDPVKMAYLRTSFIFGLAVLITWIPSSANRLYSLTHHDRISFPLSVASGCVLPLQGVWNAVIYFTTSWKTFNEEIRALRFKMFGAPEECANGVRLNSRLGSSKGSYRNTFERTRQLRAYSVEDTEKPVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRQ1</accession>
    <name>S0DRQ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427207.1">
        <property type="nucleotide sequence ID" value="XM_023573064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRQ1"/>
    <dbReference type="GeneID" id="35397212"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03731"/>
    <dbReference type="HOGENOM" id="CLU_1704373_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT65126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="154" mass="17438" checksum="DA6F480539481205" modified="2013-09-18" version="1">MTPLFPQRIFDIKIISPAQLIDELATPRLPRYRRVHNFRTSCGLVLTKPGIIVSLGDTPYSFSSNAFNADFPENPVLSQNVHTFEAFDIFQNNLFLDNHSQLPNLDLVQDDDLLLTVPELAAPDETGTGQFTSERLYLRYESDIDPQNDTPTIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-04-25" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS59</accession>
    <name>EQXS_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Trichosetin synthetase PKS-NRPS1</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
            <ecNumber evidence="12">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hybrid PKS-NRPS synthetase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Trichosetin biosynthesis cluster protein PKS-NRPS1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PKS-NRPS1</name>
        <name type="ORF">FFUJ_02219</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="Toxins" volume="9" first="0" last="0">
            <title>Establishment of the inducible Tet-On system for the activation of the silent trichosetin gene cluster in Fusarium fujikuroi.</title>
            <authorList>
                <person name="Janevska S."/>
                <person name="Arndt B."/>
                <person name="Baumann L."/>
                <person name="Apken L.H."/>
                <person name="Mauriz Marques L.M."/>
                <person name="Humpf H.U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="28379186"/>
            <dbReference type="DOI" id="10.3390/toxins9040126"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of trichosetin, a trans-fused decalin-containing tetramic acid with antimicrobial activity (PubMed:28379186). The PKS module of PKS-NRPS1 together with the enoylreductase (ER) catalyze the formation of the polyketide unit which is then conjugated to L-serine by the condensation domain of the PKS-NRPS1 NRPS module (By similarity). Activity of the Dieckmann cyclase domain (RED) results in release of the Dieckmann product intermediate (By similarity). Diels-Alderase (DA) is involved in endo-selective Diels-Alder cycloaddition to form the decalin ring, leading to the production of N-desmethylequisetin also called trichosetin (By similarity). The cluster does not contain the equisetin N-methyltransferase and consequently, trichosetin is isolated as final product (PubMed:28379186).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine + 7 malonyl-CoA + acetyl-CoA + 2 S-adenosyl-L-methionine + ATP + 8 NADPH + 11 H(+) = (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 2 S-adenosyl-L-homocysteine + 7 CO2 + diphosphate + 8 NADP(+) + 8 CoA + 6 H2O</text>
            <dbReference type="Rhea" id="RHEA:67324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:169938"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:67325"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="9">Expression is positively regulated by the trichosetin cluster-specific transcription activator TF22 (PubMed:28379186).</text>
    </comment>
    <comment type="domain">
        <text evidence="2 12">NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (By similarity). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme (By similarity). Occasionally, epimerase (E) domains (responsible for l- to d-amino acid conversion) are present within the NRP synthetase (By similarity). EqxS also contains a polyketide synthase module (PKS) consisting of several catalytic domains including a ketoacyl synthase domain (KS), an acyl transferase domain (AT), a dehydratase domain (DH), a methyltransferase domain (MT), and a ketoreductase domain (KR) (PubMed:28379186). Instead of a thioesterase domain (TE), eqxS finishes with a reductase-like domain (R) for peptide release (PubMed:28379186). EqxS has the following architecture: KS-AT-DH-KR-PCP-C-A-T-R (PubMed:28379186).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="9">Completely abolishes trichosetin production (PubMed:28379186).</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EC" id="6.3.2.-" evidence="12"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="S0DS59"/>
    <dbReference type="STRING" id="1279085.S0DS59"/>
    <dbReference type="EnsemblFungi" id="CCT65286">
        <property type="protein sequence ID" value="CCT65286"/>
        <property type="gene ID" value="FFUJ_02219"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02219"/>
    <dbReference type="HOGENOM" id="CLU_000022_37_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000443987" description="Trichosetin synthetase PKS-NRPS1">
        <location>
            <begin position="1"/>
            <end position="3914"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="6">
        <location>
            <begin position="4"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="7">
        <location>
            <begin position="913"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 1" evidence="5">
        <location>
            <begin position="2356"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 2" evidence="5">
        <location>
            <begin position="3502"/>
            <end position="3579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Malonyl-CoA:ACP transacylase (MAT) domain" evidence="3 4">
        <location>
            <begin position="525"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dehydratase (DH) domain" evidence="3 4">
        <location>
            <begin position="913"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="913"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1062"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methyltransferase (MT) domain" evidence="3 4">
        <location>
            <begin position="1364"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ketoreductase (KR) domain" evidence="3 4">
        <location>
            <begin position="2083"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2447"/>
            <end position="2518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation (C) domain" evidence="3 4">
        <location>
            <begin position="2529"/>
            <end position="2956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation (A) (KR) domain" evidence="3 4">
        <location>
            <begin position="2991"/>
            <end position="3388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Reductase (RED) domain" evidence="3 4">
        <location>
            <begin position="3615"/>
            <end position="3831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2481"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="6">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="6">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="946"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1122"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="2396"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="3539"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A0A0E4AZP0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q4WAZ9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="S4W172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="28379186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="28379186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11"/>
    <evidence type="ECO:0000305" key="12">
        <source>
            <dbReference type="PubMed" id="28379186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT65286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="3914" mass="431704" checksum="F792FA1A3D555151" modified="2013-09-18" version="1">MSDNEPIAIIGSACRFPGDSSSPSKLWDLLKSPRDLLTKVPPNRYNADAFYHADSKHHGTTNVRHSYFLNEDPARFDNNFFNIQPGEAEAIDPQQRLLMEVVYQGLCASGQTIEGLRGSPTAVYVGVMCDDWSGIITRDLEVFPQYGATGMARSIMSNRISYFFDWHGPSMTIDTACSSSLVAVHQAIQTLRSGESEVAIAAGANLILTPGRSKMWDQDVNGYARGEGIAAVVLKPLSAAIRDNDHIDCIIRATGVNQDGRTPGLTMPSATAQADLIRSTYARAGLDINKPEDRPQFFHAHGTGTPAGDPREAEAIYRAFYSDVKDDKLYVGSIKTVLGHTEGTAGLASLIGTALAIQNKTIPPNMHFDVLNPKIKPFYDNLEVPTKAIAWPETHKGQPRRASINSFGFGGTNAHAIIEAYEPATTDSAPGPLFSPLTFSASSEPSLRSLLSSYSDHLKSNPDLSLKDLAYTLQTRRSTLAYRVAITASDVEDAYTQLDTIGNGEQSSTIGVRQVTKASPKIMGVLTGQGAQWPRMGARLVEESAFASQRLFELDEALSSLPKDDRPSWTLREMILADSKSSRIAEAAISQPLCTAVQVVLVDLLRQAGVELSSVVGHSSGEIGAAYAAGLLTARDAIRVAYYRGLYAKLAQSPNGRKGAMMAVGTTFDDASEFCELDAFQGRIQVAARNSSSSITLSGDEDAIVEAIETFKDEGKFARQLKVDTAYHSAHVLPCAKPYLDAMERCQIESANPTSTKWYSSVHDGQAMTAELLTPQYWVDNMTSAVLFSPAVEHAWREGGPYDVIIEVGPHPVLKTPCLDTLEDMTGDRPPYSGVLGREKDDIQQFASGLGFIWTQLGAGSATFERFEKVASDSKSIPSFIHDLPNYPFDHARQFMSMSRVSGWYNSMQEAPHPILGRRCHDRETSQTIQWRNVLNPKEIPWLHGHQIQGQIIFPATGYISMAIEAVNIIAGSDLGLVTIEDLRIGRALAFSDDDASVESMFDLRIISRSEKEIEAEFSCYSGLPQNHTTSMVLNATAHVKASLSVPTAQKLPNLKIDDFNLRKVEVDRFYDFLGRLGYNYSWPFHGTTSIRRKANYATGTLEDQSGSEWEDQLLVHPGMLDTSLQTTFAAFCCPGDERMWALHLPTSFRSIVVNPYFTSAGIGKQKSFQYQSVAIQERKASKVIVELNLLSEETGDTFLQIEGMELVPFSPATPENDAVLFSRFDYRLASPDGELTAAEYSFRDEDYKMALDSERIAFYYLRRLVETITPEDKANTLPHYRHLVEWAAHVVPQVIDGRNPHIPSSAQKDTHEDIQNILKKHYERVDVRLLESVGENLPQVIRENGNILEHMTKDGMLDDVYEEGFGLDLVNKYIAHMTAQIAHRYPRMNILEIGAGTGGSTREILPRLGSAFSTYTYTDVSGGFFDTAQDRFKDYAERMIFKTFDMNISPGSQGFTEGTYDLVIASNVLHATLELEDMMKHVRSFLKPGGFLIILETVNNDCLRVGLPMGSLPGWWLGAEHGRRWGPTLTLPQWDSLLWKCGFGGIDTTTPPVHKILPGHVFCAQALDDRVEILRSPLSHLSDLPETKSTELVIVGGETLKVHRMCEQISRRLKPKYASIARFNSIEELNTSGLADSCAVVSLTELDEPLFANMTSDKLDALKTLWKQGGSILWVTSGARDENPYSYMTTGVGRCMRFEYPNITLQALDIKAMTDRTPGLVAEHLLRLELLDKWSKELRPEELLWSLEPEIYVDDDTTIVPRLYPYESGNARYNAERRNIVEDADLQTDRVIFVENEGKWEVQHASPLHIPQELPFASKMKTIRITHFSPATINFAPGVSLMVCAGIDAASGERLLAVTHVAESPISVPADWCIPLGELDGVDTLANVSAFLIASSILKHVATEETLVVHGAPSRLASALEGLAKESSITVFLTTSERANKNGWQYIDSHLPERVIKASIPRSATKFINLSQDANMGETGRAISACLPRYCEVINTERLFIWGKLIRESVSKEDISIVFNRAFYETKSLSSTATDARLISLQDVSGVSAAEVRFAVVDCIDSSVKASIRPIDDGRIFQADKTFLLIGLSGELGQSLGKWMVEQGARNIVLTSRRPNVSQHFLDEMATMGATVKALPMDVTNRDSLHACVDTIQKTLPPIAGVVNGAMVLRDALFENMPYEDFMKVLSPKVLGSQLLDELFYDTPLDFFIFFSSTTAVMGNSGQSNYIAGNMFMNALAAQRKKRGVAASSIDISSIIGLGYVERAEDLSEDTFIKMGYKPMSEQDLQKLFAEAIVLGRPECDEVCELVTGVTPIYTDAQASDQYLKDVKFGHFLMERLDTQAYTGKTSTVPVRVQLADVKTKADAVAIIKGMFSLLTPVIIADLERFLHFEQGVDSLMAVEVRSWFIKELDIDIPVLKILGGMSVPDLIEESLNLISDSILDVSSLEAGSTPTTQPPKPTLQIARVTPPESSHGTSDDSKQQTGSDSSRSPIDTPLTSMEIQEPAKAEDSTDNSTPLKTFPNELSSIMSYGQAGFWFLNDYLVNKRAFNMAVMLKLTGQVRVQALEKAVNLVAERHEVLRTRFFWGDDGDERTPLQGINPADLKLTTKKVADESEAGMELKKLHDEEWDLSRGEGVKITLLSLSDNVHFLLLGMHHIYIDGYSFSVFFKDLEVAYTKNTLPSLPVESQYRSFALQQRQMYANGNLTKSIEYYRRSFPKEFSPIQLFPFALTPARQFANDYSQHEAKMSIDPELAPKVRQLARVNRSTSFHVYLAALELLLFTLLPNIEEVFIGIADANRGDKKFMGSLGFFLNLLPLRFRRKRRGTQLSSIIQTARDTAYGALQHSQLPFDVLLRELNVPRSDKYTPIFQVFMDYRQVVQERSSWGGCKLHGEKWHNAGTGYDIALEVNENITTDTLLGLRLQKQLYSEEHTALLLRSYLSVLEYMVQGTNKAADTVPPWSKDDIQVALDAGKAPEFQPKWQSTISHHIDQTIQANSTKVALKDGNGTVLTYEQMGNRVNSITQALIDAGTTQGTVVGVFQEPSSDWICSLLAIFKAGAVYVPLDLRNSIPRLASIVKASRPSLIITDHTTDDKVELIGAKYITQLQLSKVVDQEFKEPNRAKVGSLAVILFTSGSTGEPKGLMMTHTNLMSYAEVSSKTFSKPDESLMVLQQSPFSFDFSLDQTVAALANGGCLCIVPASKRGDPDEISKIMVKEGVTYTTATPSEYDLWLRYSTSTLRQCTSWKYAFSGGEAMSHKLAREFGTLSLKNLHVFNGYGPAETTILSHRIDLQYTDPDLPDPLPAGCPMPGFSVCIVDEKMRPVPLGVQGEIVLGGPCIVSGYLSMPDATKDKFLPDTFFGTSGKVYRSGDRGRLCHDGLLFCDGRLEDSNMIKLRGFRVELDEVEKTIISHSAGTLSHAVVTLRGTEEGRYLAAHVVFAPEFPEQNRESIMKTLRQTLPLPPYMRPSVFQILADIPRTAHLKVDRKAIQEMPVQISASHDSGTLTVAEQRLSELWRRVLPLDPGSLSPESDFFLIGGNSILLVKLQALLRQTFKTAPKLVALMGASTLGTMAVVLESCGSVGVIDWDQETALPNGLQGAVALRPVNKITDITVLLTGSAGYLGRHLVPALVEDPRVTRVHCLVRSVNNEKLSTSSSSKVRVIESDLSKPGLGLSASTYSRLAEETDVIIHSAANRSFWDRYEVLKPDNLDSVKELVRFAASSGRSIPLHFLSSGAVKIYDGDVVTPPTDGSDGYVATKWASETFLRNAAGSIGLPVYAHRPTVSSKAQTKTDQASIVDELFSIVKFLGVRPSFEGVTGSVDVLPTGDIVKAIQDSVLSSSAGGEGYNVLQHEAHQRAFVEDFAGVVRADDSLNKLPSISILDWFGKAKKAGFSYFLASQNLVMGEGEGHLVSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DST1</accession>
    <name>S0DST1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425709.1">
        <property type="nucleotide sequence ID" value="XM_023571398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DST1"/>
    <dbReference type="STRING" id="1279085.S0DST1"/>
    <dbReference type="GeneID" id="35398703"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05222"/>
    <dbReference type="HOGENOM" id="CLU_122470_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="162" mass="18730" checksum="9A339AB26A63909F" modified="2013-09-18" version="1">MSQFDSEHQDAAEATCPGIAYKDLSPEQQEMSDILYKMEQHDLDLLGIVHLGHDGVFRYLDAERNIHYAIALRPALIKALLDRGPYDDEEEAVFRGVDGTKVPKEQWYNPPRGILPEPLSEEHRKEGREFIQKNKDKIDKNREASKNYKDHLVYIESDHKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSU3</accession>
    <name>S0DSU3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426553.1">
        <property type="nucleotide sequence ID" value="XM_023572427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSU3"/>
    <dbReference type="GeneID" id="35397785"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04304"/>
    <dbReference type="HOGENOM" id="CLU_690877_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44467" checksum="9146F1798FD7D89D" modified="2013-09-18" version="1">MPASSQQPMAPPARSEEEISTASESEAEEEIEVPSSQPAPSQSLPARRPTARQNASKRATRRAPRSDIQNPGSKARWTRDQMEYLLESYGAKRIGCELAERYPPNVFDQTKVGRKLGELLRNWKAFLAIMRETSGAGYDHELGIVTTTDDNWDRWVKKHGIGAAAIKRNGLQKMDLYQRAFDGVQEVGLTALEVTDTSGLLSLRNDMEESQIDSQIDEDLVFHSQPSAHEAAQRHLPSRPSPSPFREVTATPAPSSSQTSQLTSSPSGRPSHPTTSSSGDSQSPQRVRRPHRHVDPQAGSIEKAVSKLVTSREKSRRPIGADDTQSAVQDVQQRFLERADEGEIETFFDWLLGDSMRAVFYNSLNERMKERLFCSKSGCIVLRSPQIDLEMTQDSEFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSX8</accession>
    <name>S0DSX8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siderophore biosynthesis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425774.1">
        <property type="nucleotide sequence ID" value="XM_023571475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSX8"/>
    <dbReference type="STRING" id="1279085.S0DSX8"/>
    <dbReference type="GeneID" id="35398635"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05154"/>
    <dbReference type="HOGENOM" id="CLU_086099_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485247" description="Siderophore biosynthesis" evidence="2">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="19878" checksum="465D19659F86B66C" modified="2013-09-18" version="1">MVKSILLAAIPLLMLAEQALGFGCSTHSYTTCEDKIVHWFDPDDGMICDPLDCDGGRAPPKTGVPGCAGYTGTETIGTSYLSCWKPSTTLVAAAAETTSETTVTETAEPSTVIKVETRTTTRHAVSASAEPMGITSRTGSTTVAPILPSETKSTEEAASTSTPAAAAATAAPNAAGVMERSLIAAAGVALGAIVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTM2</accession>
    <name>S0DTM2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_02903</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428000.1">
        <property type="nucleotide sequence ID" value="XM_023574689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTM2"/>
    <dbReference type="STRING" id="1279085.S0DTM2"/>
    <dbReference type="GeneID" id="35396385"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02903"/>
    <dbReference type="HOGENOM" id="CLU_015515_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000002">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="202"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT65919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="663" mass="74343" checksum="84C7A2A61EB47465" modified="2013-09-18" version="1">MSSAATTLKGQPLDKAVLESILRRRMFYTPSFEIYGGVGGLFDYGPPGCALQAGVIDIWRKHFILEEDMLEVDCTVLTPHEVLKTSGHVDKFADWMCKDPKNGEILRADHFVEAILEARLNGDKEARGQKVEDKEEDPKKKKKKTKTEAVKLDDAVVKEYEEVLARIDNYGGPELGELIKKYDLRNPATGVQPAEPVSFNLMFQTSIGPSSNYPGYLRPETAQGQFLNFAKLLEFNQSQMPFASASIGKSYRNEISPRAGLLRVREFLMAEIEHFVDPEGGKKHHRFHEVEDVELVLLDRDTQLSGKTTTRTLKIGQAVKDGLVDNETLGYFLARIHLFLEKIGVDLTKLRFRQHMANEMAHYATDCWDAELFTSSGWIECVGCADRSAYDLSVHAKKTGAPLVVREQRETPLVIEEWQIDIERKKFGPQFKKDAKTVETALLATTQEQREKLAKELSDNGSITLEVAGVGDGKVQVNKDSIAIEFRKRVENTREFVPNVIEPSFGIGRILYSLMEHSFWTRGTEGGDEARGVLSFPPTVAPTKVLLVPLSSNTQFKPLLKQLSQRLRSAGISSRVDDSSASIGKRYSRNDELGTPLGITIDFQTVQDGTVTLRDRDSTNQVRAEQEKIIDAIKSLVNGSKTWSQIESELPKFEGQEVDVSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTQ3</accession>
    <name>S0DTQ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428030.1">
        <property type="nucleotide sequence ID" value="XM_023574725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTQ3"/>
    <dbReference type="STRING" id="1279085.S0DTQ3"/>
    <dbReference type="GeneID" id="35396418"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02936"/>
    <dbReference type="HOGENOM" id="CLU_035998_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="370" mass="41858" checksum="39455B6D6163A0AE" modified="2013-09-18" version="1">MSFCNGGIQYDIPAEHVVDADMNGIGVVLSFVITAAISVIVAVMAVLNRGIPKQQYMRVDEKVLHWIGVRKPAKESPSNLGYQSLLLALSDQMLAVGLCYLIAMYAQVCKVSLYSFYIGAQLGYLSSTVHLCTLLVLKSYFRRHPKQALLRGGLMMLFLGLLVATLILEFITLSEPRDRLFLCGLQYPVLPRLESMSVRCFSIAVMLAFVYWNAFRSIKLDNSLRYELENNTSKNTILRWIYSGGQREVDFQTYWEHEKKDKRQRTRRQAAILEQSPEFWKTFTMVTPLIVAEMAASVLFELLVAIFSFSIALYTLVIGVFYQGADVKPLLTASFGQIMPMLLLIVIALTAVEVSSESVCHTEHEIWDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV63</accession>
    <name>S0DV63_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_03378</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428436.1">
        <property type="nucleotide sequence ID" value="XM_023575219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV63"/>
    <dbReference type="STRING" id="1279085.S0DV63"/>
    <dbReference type="GeneID" id="35396860"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03378"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="11"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT66355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="360" mass="39185" checksum="4EBEAD4B98A3CF0F" modified="2013-09-18" version="1">MSVPDKFQGFQSPSAEHWTDFQKNSFEPRPFGEYDVDIKVECCGVCASDRHTISGDWGGCPYPLAVGHEVVGKVLRVGDKVTLAKVGDRVGAGAQVWSCLECHQCKNDNETYCKHQIDAYGADYLDTGFKTQGGYSSHSRVHEYWVYPIPEALSSTQAAPMLCAGITVYSPLKRLGAGPGKKVGIVGIGGLGHYGVIFAKALGAEVWAISRSRAKEADARKMGADGFLATGEKDWTKGHEMSFDIIINTATSFEGFALSEYLSLLDVHGHWNSVGLPGGDGISIRNQDFITNGCYIGTSHLGSRREMLEMLQLAADKGLKSWIEEIPISKEGLQQAMEALKTSSVRYRSCMTNYEEAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV89</accession>
    <name>S0DV89_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_03417</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428472.1">
        <property type="nucleotide sequence ID" value="XM_023575263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV89"/>
    <dbReference type="SMR" id="S0DV89"/>
    <dbReference type="STRING" id="1279085.S0DV89"/>
    <dbReference type="GeneID" id="35396899"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03417"/>
    <dbReference type="HOGENOM" id="CLU_021971_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="388"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="299"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT66391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="591" mass="66858" checksum="E7AC09E36A1CD720" modified="2013-09-18" version="1">MAADNEAPAASSANQSLPSGDNNNGSENRRNPRHDHRKPGKGRSEKGRGEWGREKGDKRKKNDEFKEFKRRKLNKKGDSADGESSNNPFSKDEIAAEERRPKRKVAVMIGYAGTGYKGMQVNGNEKTIEADLFKAFVAASAISKANADDPKKSSLVRCARTDKGVHAAGNVISLKLIIEDEDIVDKINAELPEQIRIWGIQRTNNAFSCYQTCDSRWYEYLMPSYCLLPPHPESFLGQKLVELAKEHGVEDELAARMEDVKDFWSDVEEKEIKPILARLDPETKAAVLERVHVMDDEEVAARKEAAKETEESAPAEEKPATETPAGEAAEKATEPETQQSGLVLESHKPKNRELGPVDFALRDIKAAYVAAKRRYRVSTERLNRLQEALNKYNGTKNFHNYTVQKSFFDPSAKRHIKSFVVNPKPIIINDTEWLSLKVHGQSFMMHQIRKMVGLASLIVRCGTPMERINESYQNQKMAIPKAPGLGLLLERPVFHNYNRKATESLGKEAIDFDKYEEKIQAFKDKQIYTRIFTVEEKDNSFHMFFNQIDQFKTNHFLWLTAGGTRQGEKVQQDVDKQLGDEDEEDPEGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DW61</accession>
    <name>S0DW61_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_03433</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428822.1">
        <property type="nucleotide sequence ID" value="XM_023575280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DW61"/>
    <dbReference type="STRING" id="1279085.S0DW61"/>
    <dbReference type="GeneID" id="35396915"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03433"/>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="12">
        <location>
            <begin position="35"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="519"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT66741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="639" mass="72277" checksum="813F9186676F0228" modified="2013-09-18" version="1">MATDANALADQLQQLGLDNIETSFPGCHPDTNPVDIYRSHITSLLAPITGVDPKIIYPAIQWTQTLDKGDAILAVPALRVKGKKPQELAEEWVAQFPESPLIEKPTAAGPSISFFFKPNKLTSMLLPTIRKRADNYGKNPYNGLRDPSDSNSGRKRMIVEFSSPNIAKPFHAGHLRSTIIGGFLASLYESAGWEVTRMNYLGDWGKQYGLLALAWEKWGDEEALKADPINHLFNLYVRINQDMSAEKEEIAAKKAAGEDITALEEKSLDEQARKYFRRMTDGDKEAVDLWRRFRDLSITRYKKTYARLNIEYDEYSGESQVPEEDMEKAAKVLSEKGLTEDANGAILIDFSKHVPGKPGKSLEKVILRKKDGTALYLTRDISELLNRHEKYNFDHMIYVVASQQDLHLKQLFKTIELMGHEDIAKKCQHINFGMVLGMSTRKGTVKFLDDILRDVADKMHEVMKKNETKYSQVENPEAVADILGISSVMVQDMSGKRINNYKFDMDVMTSFEGDTGPYLQYAHARLCSIRRRVGLSDDELATANYDLLTEKHATDLVRLLSQWPDVVQNTLKTLEPTTILTYLFKMTHVLSSSYDHLRIVGSEAELQKARMALYDAARIVLHNGMSLLGLTPVERYEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWZ1</accession>
    <name>S0DWZ1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PBP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427089.1">
        <property type="nucleotide sequence ID" value="XM_023573075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWZ1"/>
    <dbReference type="STRING" id="1279085.S0DWZ1"/>
    <dbReference type="GeneID" id="35397202"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03721"/>
    <dbReference type="HOGENOM" id="CLU_058099_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052738">
        <property type="entry name" value="ABC-Tungstate_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945:SF1">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495308" description="PBP domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PBP" evidence="2">
        <location>
            <begin position="37"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="298" mass="32454" checksum="66315DAB39C3B43E" modified="2013-09-18" version="1">MRSYLLALSFLASSCLAVTPDAVYGGGFDHNKNDTVKLLIANGGAGQSGLIKELANAYIKKRVADGEKPFQVGWIKSDTFYSIQYLKTGEADIGITYNPAAEEIAIKQGIAKSPSYYAFRDHFLLVGPKENPANISKSDDIMTTFANLHEAAEGPATEPPVRFLSRYDKSATNIKETLLWAGIGQVPWATAYSTWYHQYIAFPIQALTAAIILQEYTITDRGTILSLDADLRNQTVVYKAGTDKADDPLLNPAHALIGEKAPNGKEAAVFIKWLVSDKGQNVIAGFKKDGQVLYSKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXK6</accession>
    <name>S0DXK6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to Type 2C Protein Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429347.1">
        <property type="nucleotide sequence ID" value="XM_023576154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXK6"/>
    <dbReference type="STRING" id="1279085.S0DXK6"/>
    <dbReference type="GeneID" id="35406919"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13465"/>
    <dbReference type="HOGENOM" id="CLU_021928_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="191"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="593" mass="64698" checksum="29DB7E5B10EC416A" modified="2013-09-18" version="1">MNRAAVRTLRTTSPSTVRTLSRTPRRGFAVSSFTLAQARSKASAHARNARRNPAGAIPLRSSMYFRRLPVALVSSIVVGYGAWYSLNSSDTPSSVVGPRTSLASTQTADVLPTRTVLVVGADELRQGTIVGEGPISKATSDDGRRIVEMLTPDQATQKLRRLEQSFSVSRGQGVTRYDLVQLPSNDPIEDDHAEKIVQVPSRSSVETDNSDWMFWGVFDGHSGWTTSATLRESLINYVARELNETYKKASGDLPSEDAVNLAIKTGFNNLDNEIVHKSVEKVFKGGSKTVAAEILQPALSGSCALLSFYDSRSNLLRVACTGDSRAVLGRRAGNGKWTATALSEDQTGSNPQEVERMRKEHPGEDHVIRNGRVLGGLEPSRAFGDAVYKWSRDVAWKLRENFFGRSPSPLLKTPPYVTAEPIVTTTKVHPENGDFLVLATDGLWEMLTNEEVVGLVGKWIETQGQSGTNSQFDAAWNKIFGSSKTPLPVEESKTAGPDGNKTPIRVQQWGIDPDAKDRFTVKDKNVATHLVRNALGGNNDEQVCALLTLPSPFSRRYRDDLTVQVIFFGHGEKTGEVTVNLEATAGEGVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXW6</accession>
    <name>S0DXW6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to malonyl CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427389.1">
        <property type="nucleotide sequence ID" value="XM_023573949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXW6"/>
    <dbReference type="STRING" id="1279085.S0DXW6"/>
    <dbReference type="GeneID" id="35395724"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02242"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="487"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="600" mass="65190" checksum="5C1C54A7B48CB731" modified="2013-09-18" version="1">MTITLHRSAFFEAILKHEGSSVAVVENESGASFSYNSLLNSVARAKEQLLAKTGKCDASISGERIAFLVESGYEYVVTLLAILACNAIAVPLAPSFPAPELRYIINNSEALVLVSSAKYVSKAEEVLADGLNTTPLFYQLDGTRNVSTVEEEVKLRDLSDAPRGGMMLFTSGTTARPKGVVLSQTNLTAQAKCLLEAWEYASSDRLLHVLPLHHIHGTVNALLTPLLAGSSIEFMYPFSVNSVWTRLAAPFLSTGQVKSLVGETNGVKKDETKTPITFFTAVPTIWSRMLKAHESLSHDMQTAGKIAVSPRNLRLNISGSAALPKPIRDGWMQLTGGNVLLERYGMTEVGMALSCGLETADRVDGSVGWPLPSVEARLMETDDETGVQRIIEHGAEIDVHSTKERIGEIQLRGPTVFTGYWRNPEATAKEFTTDGWFKTGDIAIRRKVPESGLGKSGSWAKGPAYFIQGRRSADIIKTGGEKVSALEVEREILALPEVDECAVVGLPSEAWGQKVVAVIVLSTKAGESISLQGLRSALKARITAYKIPQDMQIVEVLPRNAMGKVNKKELVKSVFGEAEKIRRRSIDLETKRPVLNGQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXY3</accession>
    <name>S0DXY3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428333.1">
        <property type="nucleotide sequence ID" value="XM_023575092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXY3"/>
    <dbReference type="GeneID" id="35396747"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03265"/>
    <dbReference type="HOGENOM" id="CLU_150841_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="120" mass="13742" checksum="142E822CAB2796CB" modified="2013-09-18" version="1">MNPTAPTTAAPTSGNANSYFSIHKTQSTETTPVSTPGFKSEEFDQAGHKLPALNREFPKPTEELDIQSMLDRQPGRWTTKGQIEANHRRAQHARNEEEIKAQRMRDFEKAKEELRSSWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY64</accession>
    <name>S0DY64_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to isovaleryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02342</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427484.1">
        <property type="nucleotide sequence ID" value="XM_023574060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY64"/>
    <dbReference type="STRING" id="1279085.S0DY64"/>
    <dbReference type="GeneID" id="35395824"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02342"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000014">
        <property type="entry name" value="Probable acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000027">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="48"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="165"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="277"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT65403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="445" mass="48368" checksum="E12DA83A235FB9A5" modified="2013-09-18" version="1">MSQSTARALQRVKGSCSPSLWRSPPHGFARRSFSATCSRRLMDTSGFSDTQLTVREAVSQLCSNFPNTYWQERDQAEQDPQDFHAALAKDGWLGIALPEALGGAGLGISEAVMMMQTITESGAGMAGAQAIHANVYATQPLAKFGTEKQLQSTIPNIIQGKWRVCFGVTEPNSGLDTLRLTTTATKQPDGSYSVSGQKIWITCAQVASKMILLARTAPLDPKKPSQGLSLFCIDLNRDQQGLDLRKIRKMGGKAVDANEVFFDNYSIPADSLIGDEGQGFKIILHGMNAERCLLAGEALGLGYAALNKAAEYARDRTVFQRPIGQNQAIAHPLADAYMKLEAAKLMTYHAARLYDDSSKEDSSPDAKISPASVGVACNSAKYMAAEAAFTACERAVLTHGGMGYAAEYDVERWFRECLVPRIAPVSREMILNYISEKVLALPRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY69</accession>
    <name>S0DY69_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428433.1">
        <property type="nucleotide sequence ID" value="XM_023575215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY69"/>
    <dbReference type="GeneID" id="35396857"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03375"/>
    <dbReference type="HOGENOM" id="CLU_648985_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="51515" checksum="BD47241D488E794D" modified="2013-09-18" version="1">MNLQNLPQELIYIICESLCLHCQIDTKTPASFLHIDSPGERGIRKTQLDLCLLCKRWGYIARRVLHHSYGFPERSDRGDVRFCRTICEKPELGRFVKRIYLRQMFQLDWDLDKDDDAWLLKSLDKFSDILNLPPKPFNFSKGAWSSFIIPLILLQIPTVEDLQIDTRNLDHLMQQIKKPPESHLHTFPQNVVKVTMSEGPHCQEVFPLRGPVDLSDTAGGGLLSNIRGFDILIIGNPTRQTIKSPLQLDSVRTLHLIDVCLVREELQLLVSATGPLEVFKYMGGFTQEPNPATAQDICEVLTTKKDTLTEAAVLTHYKARYLTAARTLENVTWLRITTKSIWKRTESEPTLHDQALVDIFPPALSTIIFEADREDMEGLSAALTKYILSNCPDNPEDQILKSVQIHIHLGIPPEGVRNPPVQEGNPSCEKIRHECALFLERGYIEVNFVYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYF2</accession>
    <name>S0DYF2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_13214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429637.1">
        <property type="nucleotide sequence ID" value="XM_023575871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYF2"/>
    <dbReference type="STRING" id="1279085.S0DYF2"/>
    <dbReference type="GeneID" id="35406668"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13214"/>
    <dbReference type="HOGENOM" id="CLU_129470_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT67556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="96" mass="10600" checksum="0A8977983E4FAE07" modified="2013-09-18" version="1">MAPAAGAKKQKKKWSKGKVKDKAQHAVVLDKTTSEKLYKDVQSYRLVTIATLVDRMKINGSLARQCLADLEEKGIIKPVVTHSKMKIYTRAVGGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E175</accession>
    <name>S0E175_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_07216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430515.1">
        <property type="nucleotide sequence ID" value="XM_023577443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E175"/>
    <dbReference type="STRING" id="1279085.S0E175"/>
    <dbReference type="GeneID" id="35400693"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07216"/>
    <dbReference type="HOGENOM" id="CLU_048953_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT68435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="306" mass="33781" checksum="806AA7510BD2CA35" modified="2013-09-18" version="1">MTTNTPGLSPDQLETFNRDGYLILPGALSSSTVKSLLDETHNLLESFSLDDHPLTRFSTGEKRDHVGDDYFLTSGDKIRFFFEEDAFDDDGKLTKPKARAVNKIGHYLHALSPPFARLLDHDTSKVSPPAVARSLGFKDPRCLQSMVICKQPEIGGAVPPHQDSTFLYTNPPSAVGFWYALEDATLENGCLSFLPGSHLWAPVEKRLVRKAGNVGTEMVDNDGPKFPEAAGYGQAAPGGPHKYVPGEVKAGDLVLIHGNLLHKSEKNTSQKGRIIYTFHIIEGQDRDYDDKNWLQPPNEGFTKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2G5</accession>
    <name>S0E2G5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_14595</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429933.1">
        <property type="nucleotide sequence ID" value="XM_023576546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2G5"/>
    <dbReference type="GeneID" id="35407976"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14595"/>
    <dbReference type="HOGENOM" id="CLU_030987_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT67852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="496" mass="54163" checksum="90D4CE2571460345" modified="2013-09-18" version="1">MDQSPMKDDAPDGQRPVMTDINVTEVGNPAFDHLRIPAKYKWTALCFVVALPIGHTWTGSALGPLKNTLREELDISNTQFGVISSADAFVNTIFPIVGGLILDWWGPNIVTLFCTSFILVGSVVAAVGVQIGLWRLLVSGHVLMGFGIAVLDSATQKFFYHWFGASGLALAFGLESAISSTVGLVSGMVAIPIRDRTGWYGWTFWIPVVFCGLSLAMNISYVCFERFVVPTKYRLTPGRDAAIIEKHLTIKRNFSWELLLTLPWAYLMLPATQLLQSGAAGGFNTSSADIIFLKGYTEEVAGYLSTAQRILPIVLSPALGLVIDKYGHRFHYVAASPILWIIACSLLGFTDAHPTVALVFSSLAGVINSMPLQICIPLLVADQTKIGTAFGMDVIFGVLQDGTEDNGYYKVLLVAIGIKAWAFVLGVSYIIVDYKLLGKGMTMTRVQREAKEAVIEDCDADPLTRRRSKPWFTALTFGLLVAIIASAWAVFLKYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2K5</accession>
    <name>S0E2K5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_14748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429973.1">
        <property type="nucleotide sequence ID" value="XM_023576716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2K5"/>
    <dbReference type="STRING" id="1279085.S0E2K5"/>
    <dbReference type="GeneID" id="35408128"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14748"/>
    <dbReference type="HOGENOM" id="CLU_032417_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT67892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="559" mass="63993" checksum="C0EFEC5427E1E612" modified="2013-09-18" version="1">MIPANALRNTLQLGKTKRSGAPKSRSGCLSCKRMHLRCDEAKPTCSRCQKSRRSCEYVQAGQITSQAPIRAKLLLPKQGPASHEILSISPLLIQPTSSSLKPHEVPYFDLFRYQMAHDFGYTPCTLFWNKVIPREAMNDDCVKFSVLSVGALMQSLYRLGPRPYTGLKPFSDLSRASSDPTYRMALYYHSKAISTLQARIKSNFATVSRRNTLINMFILFLFELMHGNTATADRMLTSSVELLRQQKDQLAEEVNQGFEPQPGPIYTAISNDEGLDQAERILPRLQVFFSLNSCFFPLQRDCWSRFSTQAIPCTVPSAKTDFNQFAAMWNSFITRAVIFVVKILQDRSYCDTFHRASLMARRDMLLKQLRQWEIVIIERLDVETNTVAKNTTKIFHVGQKVVYILLNCCLDPMETAYDKYDSVFADIMDMMHSVEGTSGPSTRIETVLDIYVLPVLNFVSQKCRNKAIRSDSLNLFEKMTSTMGGWETRASLLARRRLMEIEEAGRDENGVIPTGSRYIWTDTFWDKDQSYLTVYFHEAGYRTLCNKVIEDKIYLEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2V9</accession>
    <name>S0E2V9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431269.1">
        <property type="nucleotide sequence ID" value="XM_023578464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2V9"/>
    <dbReference type="STRING" id="1279085.S0E2V9"/>
    <dbReference type="GeneID" id="35407770"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14318"/>
    <dbReference type="HOGENOM" id="CLU_093914_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="106"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="246" mass="27550" checksum="6F7F702DDC8A38B0" modified="2013-09-18" version="1">MSTPLELFSLSWGMYPRRVLIYLAEKSLLKSPLIKITEVTVSPNSNSLTAPGKPKGTAPILRLPDGVFIKQSIAILEYFEDICDNPQQPWQVELAKDAGGSMLGRTAEEKARVREVLGLADEITSQFGFACHKGTALFDMLEETHPVTAKLALEYCTKNLKLLEKYYEGDTRFNGGDGRVTIADCVLYSTLHFAKDLYSLDLLADHELVSLRAFYSWFSGRESVQVPETHFPAQIKELACQWLPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3D5</accession>
    <name>S0E3D5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to OSBP-related protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_07373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431434.1">
        <property type="nucleotide sequence ID" value="XM_023577618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3D5"/>
    <dbReference type="STRING" id="1279085.S0E3D5"/>
    <dbReference type="GeneID" id="35400850"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07373"/>
    <dbReference type="HOGENOM" id="CLU_007105_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GOLD" evidence="8">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="210"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="903"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT69354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="981" mass="107879" checksum="7FDDA38F80BDA81C" modified="2013-09-18" version="1">MAGIEQLESYIVRWVKVDEGNTLSWSVQPHKKSINFGIVKHPGSGATTFASSTAEDLNNGTEESGGTSDGKSARFSKKDINAQELLKSKGFIPIKWIGKCEADKVSIGTYEVNHDQSGMYGLVFDNTFSKQTSKTATFVVMTYPTGAPPQTSSHLPNLQAPKAGASQTSLGRHSSPKLDGLASASLDSLHSHNAVANANSVSGRSEVGSGNYHVGVLHKRRRKKGQGYARRFFSLDYSTCTLSYYYNPKSSALRGAIPLSLAAIAADERRREISIDSGAEVWHLRAPNDKEFQDWAHALEKASRVARGLETLDLPKNDHLKINTRQLQPIHQSSPQEDREWEQVESLVSRVVGTRDALRRLTREVTAQAKPPPVTSPQYLSPGAATSAIDENDTYFTPPPEQRRSFWRRKSNTPAISPATLGAPTAMAVPAPGGVTTTISANVPNHSRRQSKGLVREENSLQDHCQSLLMDLDSVVSEFTTLINNSKRRRMPVPLSAGGVSRKSIDTVSTADEFFDAEDANSAVLKIDGSEDEASRSEEAEDEEEDSFRDNSSVSSIGENDTANLDDASHLFPTKPKSLTPLPIEQVVVRRSTIPPAAAAAPSLIAFFRKNVGKDFSTISMPVTSNEPSSMCQKVAEQLEYAQLLNQAAKQSSPTDRLLFVAAFAVSQFSSGRAKERAIRKPFTPLLGETFELVRSEKEVPGGFRLLVEKVQHRPLLLAMQADSANWSFSQSPAPGQKFWGKSAEITTDGRVRIVLRLSNGSEERYSWNIATMFLRNVVMGEKYVEPVGTMHVVNDSTCHKAAVEFKSKGMWGGRIEDVSVEIFNPEGVNTGSGLVGTWTNSLKTTGKGGGQEIWRVGPLVENAAQTFGLTTFAASLNEITEIEKGKLPPTDCRLRPDQRAYEQGAIDDAEDLKQKLEEAQRGRRRELEERGETYKPRWFVKVENAPEGEEVWKLKTGKDSYWEERAKGSWQGVEDLFKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3T6</accession>
    <name>S0E3T6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_07104</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430407.1">
        <property type="nucleotide sequence ID" value="XM_023577319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3T6"/>
    <dbReference type="STRING" id="1279085.S0E3T6"/>
    <dbReference type="GeneID" id="35400581"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07104"/>
    <dbReference type="HOGENOM" id="CLU_013783_3_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF10">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485569" description="tripeptidyl-peptidase II" evidence="17">
        <location>
            <begin position="22"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="18">
        <location>
            <begin position="220"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT68327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="618" mass="68057" checksum="976E6DF6F6DA0EB3" modified="2013-09-18" version="1">MLVTRSLKLWGLLLGATSVLASPIVLESLDETPADWQEFDLPDPDQTIDFSIGLQPEDSQLLVTALYGVSDPDHPNYGKYLSRESAKALLNPSGEATESVKRWLTDAGIPEHHVRDEGEWLHVRTTFSQAEGMLSTRFSVFARDNERIVRTKEYSVPHEIVHHIATIQPTTFFPVFDKEGNVDDSGLRLTKRHDKNGKKQPKDGNNGGPGPINLEKCKTELTPACIREIYKIPKNYPKAEKGSLYTVVSFLNMTAQNAQLQEFFRRFAPDLGGVTFRNASAAGGENPQSARIRSNEGNLNTQYAISLAHQVPVEHLTVGGFNYDFNTDLDLLKVPGDFTRSIENWLGLAEYLLNLPDKKLPQVVSISWGNYEQHIPKTYARQVCNKFGQIGTRGVSILVAAGNFGVGVSCQSNDGKNTTKFLPTWPSVCPYVTSVGGTESNNPERAWLDTEYDQSGGGGFSDLFSRPAYQDKVVKDYLKKNEKKWKQWKNYINKDGRAFPDVSALASGHQVMVNGQQFTAGGTSAAAPTVGAIIALLNNERFKKGKSAMGFLNPWLYKTGQAGFTDILEGKTSGCPGVSLEGFPSPEIPNAGWDVVKGWDPATGFGTPRFDKLKKLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3V2</accession>
    <name>S0E3V2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to jacalin-like lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429479.1">
        <property type="nucleotide sequence ID" value="XM_023576311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3V2"/>
    <dbReference type="GeneID" id="35407061"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13607"/>
    <dbReference type="HOGENOM" id="CLU_009601_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="633"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="778" mass="85598" checksum="1F31A7DF0CDE4729" modified="2013-09-18" version="1">MAPTFLNNLRRRSRASFRTNRSTDTSSDGATSQATSPSSGSLTPPSIDHQSDPALHLQVKDQQQLQRRQSQMSQSQSQLNVPTRPPLSSNSNRNSVSGMSGLGAPSINGRQTLPMSPYAPRVINITENAWVYQKVLLVYGTIGNAAENPLDGTLNVCRLDDNFPAISWPVCNSHFKALVYLQPGPNRLRFEFSSPKLANSNSSNPIHASYLTVHMLPLTNSPPLQLAILVAKDSPETFDASPARVEKEGNGLEMAVKKFRMAAYLWQAFTSEQMWRNKLGRRAFRFDEEWTTGSANYRDQENGTMRSEARVHIIRSDNTLAEIRDLNKAQQNEKATDKGALYGIASEAVRKYFNPLPGQKLYVSCLLLDSHWDTAAKTVTGHAALGGGDGDLQLAIFGSHCLHSYPSTFEEVVPAFTDCTPTDTNHVANDCNEAGSSWEAANIGIGAHMHETGHLFGCPHQESGVMLRDYVVLNRTFVAREAYCTRTKSKGGLALQADECGWHRLDCLRFRAHPSFRLPNDPPMSPDGSVQAFPVENGNVLVMAATGIFFVEIYADGDDVCHAWIEYPTDQGTPSRQITLTESELRGRLPEKKRKGSLKISVKSYGGGSLEIDDYKKFTSKESLIKLLNGKSAFRSQKLGSSKMDGSQPTEAIFTSAVKQDRVLSRVVIYHGMAVDGMEFIYDDDSRQLFGKKGGKEGGDTFEFDVRRGEYISGFVVRSGFWIDGLQILTSLGRKSPVYGNAHGGDAHTLIPPRGYIICGVSGSCGQWLDGFSVLITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4D3</accession>
    <name>S0E4D3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable ERV25 protein (Component of the COPII-coated vesicles)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_07314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430607.1">
        <property type="nucleotide sequence ID" value="XM_023577552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4D3"/>
    <dbReference type="STRING" id="1279085.S0E4D3"/>
    <dbReference type="GeneID" id="35400791"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07314"/>
    <dbReference type="HOGENOM" id="CLU_066963_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485282" evidence="9">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT68527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="218" mass="24760" checksum="624E0C83BF5AC3E6" modified="2013-09-18" version="1">MALQQKLVQYICSVLLLVSAASALKFDLIAQAESSKRERCVRNFVGKDTLVVVTATVDGYKGDGMVVNLYIRDAVGNEYGRPKDVVGESRTVFTSHADAAFDVCFENIVTGSQRINNPTRHVELDIDIGADAKDWSAIQATEKLKPVEAELRRIEEITGELVTEMEYLRIREQKLRDTNESTNNRVKWFGIATTWLLIGLWAWQIMYLRAYFRSKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4J9</accession>
    <name>S0E4J9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to tol protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_05461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431645.1">
        <property type="nucleotide sequence ID" value="XM_023578675.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E4J9"/>
    <dbReference type="GeneID" id="35398940"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05461"/>
    <dbReference type="HOGENOM" id="CLU_230430_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="351"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1222"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1325"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1358"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="4">
        <location>
            <begin position="1766"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2178"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2273" mass="257187" checksum="97B0B626B9FD1621" modified="2013-09-18" version="1">MEKIIGRFSKSSDRNDDTPAVNAGSTPQSAVAASTSPGRSCDMTDESDLFGLYQLWPPKNDVYEVQNTKVDIIAVHGLNGKAFKTWTQDGKLWLADFLPLEIPYARIFTFGYDSRVAFTGSASRVNDHARNLLERLMAKRRQFSEERPLLFICHSLGGIVVKRALAIAHERSRRYNPITRDTFGIMFLGTPHRGSDVAFWGSLLVKLADVVTLGSIRTQVLEDLKRKSDMLGAICSQFIERSESLHRIFSIYERQRTKGASGLVVEEDSAVIGLPNEVPISIEADHRSMCKFSDMTSEKYQMISDCIMEMVEDALDRPNTTQNPLRDRFLRSIKTLDPEEVLRNVTRPSPGTCSWITETSAFRDWRDQSTARILWISGAPGAGKTTASRFLIDHLRRWLQKNTSSAVRGSIVAFFFCASKQWLRNSDVQIAQSLLFQVLSHNKGLFRYLSDSDMQTVCSIDRANAEPHVVWRLLTTVFQRSPDLNFWILIDAIDELQDTSRTALVQRLRHLVSNDLGQKLKFIICDRSSPNARGILQSVTWLDIRRQDMVFEDIRQFINARLGDLCSSGAIPWQYQNLIEESLLEVSEGNFLQVALAWSHFTAGVSYWSAQVIKSRLEGLRRLSGEARAFYCSLLQKIPEDSQDVAKIGFTWVLGSRKPLSLSELQHAVAISAGQRTWSDLKNALGFNFDAHFDQAFGYLLRVDPDLRVRFAHSTVKELLTADDSLASSPKSGVISKYVVREADIDAELAKRCITVLSFRDLAKFRDIAREAMADKMRDLFVMSLQGKDYLDSLDLSKYDDMDVIESEPEVKERIGTAMLKLGQTELDDRTRGLFVYCVSYWNYHCNHGLSDPEVNKSLTDFALLRQSHYFLMVAILLGLARYHTGPFWDSIDQFSRLPPMHFILKAGDYPNVLSDLLHRGEDINGTDSRGWPPLLWALIEDRKQCLEMILANHKTRMESTDRDASHVLHLALEAGVNPTLILRLIADPRVELNAKSRKGWTALQWCLSRVSLQSVSFELLRRKNVDIYEQDCHGLNALDQIFDEGVSEQSALKLISRSDVPANWFEKARTFRHSTGLNYLDDDVPRTFIHRASSLRWYSLEDTILACDPFKAVTVDGDGFTLLERYAYHGMKKRMIEILKGLPSNTFQRSNDCGSKLLILCAQQDWEQVVNVLVYEFSVDDTSTDSDGRSIAHWACELGWVSLSSLLISKTREWLNKTARDGKTALHTAAEYRNYTACKDLLQAGASHSIRDRSGKLPIHVAAEQGHREIVKLLLESPIKDLRACEVDKEGRGILHYIVMWHSDSFIRQCLAVLQPQVSTKDSKGRTPLHFACIFGNEPAVSVLLNIGLDPDKRDASSFTPLHHALMEGSVKCAQTLIRHGARYDLNDKFDRNIVLLALRSENTSTVESLVHFLQSKYSPSEIAREAGHVDRFGRSAFHYLCHWVDPKKSDDDDGLDEVVEELNDDRDIDPAETQQVLSPAEWLIKAFAAIGVDINTRDHHKHTPLHASGRAGNLAAARALLRVPGIEVSPKDEDGFTPLDWASVNGYGEISAAIEAHGGVHSSDWTLKLKPMYRSWQSGFDEDDEIEEDADDIQPRNPSVGERSQEQEVDLDWNVTNYLSIAFHPGGDKCDACEFLRRVVKWWRVYDESVRALELKRVPVSLHYVFTLGEADQYDGKEFHIDCPVTAATDLDMGTPLRLQPHLSHINEESILWMKSKLESCVSHNHFNSNKTFIPDRLLDVRENRLSLVLTKDWQPRGAEIHRYVALTYCWGPEPHARKQLKTTRDNISQHQRQIPEFSLPQVIKDAVSVTRALSVPFLWVDALCILQDDVSDWENQCAVMERIYGNAYAAVAATFSDNCEQGFLKKTERILVPFRTHLNDTYAFAIYSPPHLINDANEVSDSPWARRGWTFQERISSTRILMFSKGDIYVKCKYFNESTGGHRVTHEEYYIMLDRVTIDSGSTAANYQEWSDIIAQIHPRRHQLTRKTDFLPSIAGIASLFSKRLNDDYAAGLWKNNMHQSLCWAAGEEDKPSHQDLLQRLRAPSPYIAPSWSWASRREDFLFLLYRPNLSGGCRPEFHSLDTAIALRGESAFGEVRHAALDITSRVHVGSPRLALHKLIRLSGEPDTIAFDGRYFADIHPDCFVQSFFGRTEGFALQAPISFLLIGSTIPHETDTGDISPRYPKSSKNVNDEADAGVVSEVPNTSSTSAERGAGLETETRSKRLAYGLLIHPTGNPNEYYRVGTFFSKPHSAGGLSFFDNVEVRTVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5D4</accession>
    <name>S0E5D4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable oxidoreductase CipA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431990.1">
        <property type="nucleotide sequence ID" value="XM_023579091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5D4"/>
    <dbReference type="STRING" id="1279085.S0E5D4"/>
    <dbReference type="GeneID" id="35399313"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05834"/>
    <dbReference type="HOGENOM" id="CLU_044876_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="343" mass="38172" checksum="08CCDD92A52D214F" modified="2013-09-18" version="1">MAQHYAKDQPEGFVNKIERVAIIGAGGSVGKYLAKYLIATGKHTVTAITRKGSTSKFPEGAHTVTVDYDDDNSIVEALRGQQFLAISLSVSAAPGTQEKIIGAAAKAGVPWIMPNCYGIDFTNKSLADENLTGRSVLPGINAVEENGVSSWIAMCCSFWYEFSLAQGPEWYGFDVTGDKKKVTFYDDGNTRINSSTWDQCGRAFAALLSLKVIPDDENDKSPTISQWRNKPLYISSFLISQREMLDSFQRITGTTDKDWEIEYEDSKERWQRGMDLLKKGDHSGLGLAMYARTFYPNGDGNFEAKYGLANEALGLPKEDVDEANKRALKMVEDKYNYFVNRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E813</accession>
    <name>S0E813_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432011.1">
        <property type="nucleotide sequence ID" value="XM_023579114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E813"/>
    <dbReference type="GeneID" id="35399334"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05856"/>
    <dbReference type="HOGENOM" id="CLU_085775_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="277" mass="31388" checksum="54F7F8A1A5F97E58" modified="2013-09-18" version="1">MPLVPSSAPLPSSMTTIAYLREQEILNIVYIGLLVIEVLMVLGVITMALVKRVKVNHQLKTIRSATTSAKYAPYHFAHADTEKTIVALMDHETTVILDSPNIFGDRPKSRCPHCKFYPKHGKNKVCEACESLMGKDEIEAFLGGVERNWCVYHLNRQGFLSGRAALENAMRARLIQEQRCIRLCCAGPKLPIYVHCEDCREMLLCKGVPIAVANRKIYELPHFDAFPDYDDDSFAVRVVKSEASVYEKDWNWDCSLAKFVHPNRKRFAGNISPEEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E869</accession>
    <name>S0E869_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433163.1">
        <property type="nucleotide sequence ID" value="XM_023580378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E869"/>
    <dbReference type="STRING" id="1279085.S0E869"/>
    <dbReference type="GeneID" id="35402348"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08873"/>
    <dbReference type="HOGENOM" id="CLU_987107_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="282" mass="31090" checksum="43D0C38474F91AD8" modified="2013-09-18" version="1">MSPDLQDPANRRASCDQCRQKKLKCDGSYPSCGRCSTLGELCKFSARMPMGRPKKRKIASENEGQESSASRTSPSTLAMSIGSDNGSDMGRRGSFDPCQHMSEDAPLDLIPLGNETNVDPKLLAFESDPGQQTCACLASLYLSLEEVRKADDLPFTARLSVLRHLTTTAAGIIQCQVCPTKFLWAMQNAQLLNTLIISLAEGYKKIVKSVEDETKRAQDARESKELCISEGQKLEAPSQNDGLGFSLSLDPQDWKSIANKAIKSELFDRICGIQERVMYRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8I4</accession>
    <name>S0E8I4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to CDC31-spindle pole body component, centrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_06021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432161.1">
        <property type="nucleotide sequence ID" value="XM_023579299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8I4"/>
    <dbReference type="STRING" id="1279085.S0E8I4"/>
    <dbReference type="GeneID" id="35399499"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06021"/>
    <dbReference type="HOGENOM" id="CLU_061288_18_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT70082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="201" mass="23092" checksum="C4F84E6D21395996" modified="2013-09-18" version="1">MNSHATPRTAFQGRSLGGSGLPPQSRQPVAAQVSSNEDYSTIPEEDREHIDEVFDLMDMKKKGWLNSYEFRHSLAALGFDMSKPDYFRELQSYGSVPPEWQDPHNCPVNRLYVYLDQFRLCAAKLLANRDPRQEATKVFNMFDYDGDGVISFEDMRRLASDIKEERTMTDEEIQSMIEHLDHEGKGGVNLEEFIQMMEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8L4</accession>
    <name>S0E8L4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_09007</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433044.1">
        <property type="nucleotide sequence ID" value="XM_023580230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8L4"/>
    <dbReference type="STRING" id="1279085.S0E8L4"/>
    <dbReference type="GeneID" id="35402481"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09007"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="5"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT70965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="360" mass="39129" checksum="8E9B52ECF39A7AF3" modified="2013-09-18" version="1">MGYPDTFEGFCVDSPKSWNKFQKQTLKPKTWGDRDIDVEIEACGVCGSDVHTVTGGWGDFEGPLCVGHEVVGKAVRVGDNVKDIKVGDRVGVGAQVASCLECKLCKNKNENYCPDMVDTYNCTYPDGSVAHGGFASHIRAHEYFTFKIPDALKSEQVAPLLCAGITTYSPLVRANVGPGKTVAIVGIGGLGHMGIQWAKALGAEVYAMTHSPSKVEDAKKLGAKEVIVTTDENWADKYKFTFDFILNCADMTHKFDMNAYMSTLNIGGEFHIVGIPDEPLPQMTAGTFAGNAGKITGSHLGNHQEMDAMLKLAAEKNIVAWVETIDISEKGCAEAVERVKGNKVHYRFTLTGFEKVFKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E954</accession>
    <name>S0E954_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to xyloglucan endo-transglycosylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433483.1">
        <property type="nucleotide sequence ID" value="XM_023580763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E954"/>
    <dbReference type="STRING" id="1279085.S0E954"/>
    <dbReference type="GeneID" id="35402002"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08526"/>
    <dbReference type="HOGENOM" id="CLU_1081970_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF5">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495670" evidence="1">
        <location>
            <begin position="18"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="298" mass="32703" checksum="2F3E14207FFACEBA" modified="2013-09-18" version="1">MILPLTHLLATARLVSGACECGYSIKNPQGESQIVFTDRLETKFSQLHSISEGHNWLAQNFTVSAADGRGNFSKAFLPNNVNTHGTKSGDGSGLELRYFNDTQEIDIEFLSQEFDHDNGIYPINLVVQSKKSLEAGYDASKTGSFKRVKLDFDPTDAFHEYRFDYLPGQVLFYADGKLLAHMKGGDMPSSGGHLILQHWSNGNPLWSGGPPKEDATVTVSYVKAYFNSSSSERQSQLARRCHESSKENPVCAINGSDNDEIDSAGASPRRIAQVNSVCVLIVGLVMPLLQLSHVFLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9X2</accession>
    <name>S0E9X2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to increased rDNA silencing protein IRS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431368.1">
        <property type="nucleotide sequence ID" value="XM_023578153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9X2"/>
    <dbReference type="STRING" id="1279085.S0E9X2"/>
    <dbReference type="GeneID" id="35401330"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07853"/>
    <dbReference type="HOGENOM" id="CLU_014603_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="509"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="622" mass="67174" checksum="D3F86D5E6C2B4889" modified="2013-09-18" version="1">MTPVAAHTTGSSDAAAALRGATLAFNKTKPAPPPPQKDNGALTAATSAGRPRSPTKNLGAQSTGGSTIDNEQYGQNGQNGGSIAARLRQLGHSPGQLHPSAARGGTDPKSASFIAATLAASRSASPSPKARTPRRRTSIEGSSSSGEIVDSGPIAPTGSLISMFEQSRAGDPVKRSSPKRTPVKAPKEQVDSISEEGITQDERRSLETKPKPKPKPKPKPLTPEPRTPTKPAPEVLSPKPTLPPKPVLSPNPALSPNPALSPNSFRRPKTPPQIVTRHATNLIPTPSPDPQKHNPKPREQPKQRPPTPPQPRGTSKPKVESKSVLHEKSPTITQKRAAPPLEPRLSRPRTTPPTPTEARPTSALTVSSDDTFVSASSVQSPVRESPPVMPVKRHFTGSVPPSPTRDFRRSQFQSSSATSLPLESLTSAIVAGSLASARLTPHNTGGSLAPPLPRRQKSPRLMQTLRQPPKPLEEDTDRHKRKGLKLHKGKHAHHEGSRKKWREEVTPRERKRYEAVWASNRGLFLDLPNAPLDAMNGDPSEYVLNTVVREIWKRSRLPADELAEVWDLVDRKGRGVLGRAEFVVGMWLIDQRLRGRKIPAKVSDSVWGSANGIQTKKHGHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB74</accession>
    <name>S0EB74_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable nuclear protein SNF4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433081.1">
        <property type="nucleotide sequence ID" value="XM_023580276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB74"/>
    <dbReference type="STRING" id="1279085.S0EB74"/>
    <dbReference type="GeneID" id="35402439"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08965"/>
    <dbReference type="HOGENOM" id="CLU_021740_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="221"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="298"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="374"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="448"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="510" mass="55392" checksum="4F90AA22FEA6E5BE" modified="2013-09-18" version="1">MEGNQELEPARGNPETKAPADINLPSEPHEIQSQIEVTEAQIDDPAKENVKSWIEAQSETQPQPPTEPPTVEVDDAVGELPRVENTPSPVPGVTGTTVEASTTTSAPGTDTPGQVQESAAEASFGGVGAVSGSGPGPALITPRRRAASTSTGPSTTAAAGHGLVPQFVAPSSYLRRRTSLRSPMAPTEPKPLSPLDRDQLQGLNAIRDFLKVRTSYDVLPLSFRLIVLDTDLRIKKAISILTQNSIVSAPLWNSKTSRFAGILTSTDFINVIQYYCQFPDEFSKLDQFRLNIEKAIGAIPIETVSVHPSKPLYEACRRMLKTRARRIPLVDVDSETNKEMVVSVITQYRILKFIAVNNEHNTVLLKKTVRDIGLGTYSGIATASMGSSVLDVVHLMVKHNISCVPIIDSHGRVLNVFEAVDVIPCIKNGAYDDLDGSVGEALCKRSDESPGIYTCSEGDRLDSIFDTVRKSRVHRLIVVDDDNKLKGIISLSDILKYVLLYGVEDTSNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBF3</accession>
    <name>S0EBF3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434349.1">
        <property type="nucleotide sequence ID" value="XM_023581690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBF3"/>
    <dbReference type="STRING" id="1279085.S0EBF3"/>
    <dbReference type="GeneID" id="35405577"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12121"/>
    <dbReference type="HOGENOM" id="CLU_009942_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495793" description="Amidohydrolase 3 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="3">
        <location>
            <begin position="74"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="656" mass="71282" checksum="3BE78ACCB46B4C11" modified="2013-09-18" version="1">MARGLLILCVSALLATASAVKPVVKPADVVFVNGEIYTMCPSNGHAQALAVRGGRIEYVGSKKSADKYIGKNTKVIDLKGKMAMPGLVDSHMHVLSGGLFLLKCDLSYQTLPIEDVIEHIQGCIDGETGKRDDDWLEVVNMDYAGLVEKSGNVGKKQLDKLNTKRPIIIRSSDYHTVLANSRALELSDIDSSTKDPSDGKIVRLPGSQEPSGALSDGASALLAGPPPPTAEENVQAGRAALKLLREAGITTFQEAAAGEEHHTLFSTIKAEDGLSARAYFDYRIEAPKSVDGVPALVKDVVKKLTPWHDNKAIGPKPTLKWQAIKAFIDGVITYPANTAALIDPYWAPVNSSNLDGKWAPDKKSLNNPYWNPAVLTKTLELLFLAGFDAQLHVDGDLAVRVGLNAAESFRKKYPSKDFRLGLAHDELSHEKDWPRFAKLKVDPIVSYQWAQLSSFYIPNTFKSLADYRKDNLQAWAEIEKAGRPLVYGSDWPIDPLDEFLALKVAVTRSGDPQNPNSPASQGPPFDGKFPGNGISRTSALQSITINGARFLRADKQIGSLEVGKLADIIILENNFFKVPESKLGRQKVLLTMVGGEVVYVADGQNFGVKAKFPNDDKASAKLARRTIGGFNANALSERAKADAAKLRKRGTCVHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBH9</accession>
    <name>S0EBH9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433186.1">
        <property type="nucleotide sequence ID" value="XM_023580405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBH9"/>
    <dbReference type="STRING" id="1279085.S0EBH9"/>
    <dbReference type="GeneID" id="35402323"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08847"/>
    <dbReference type="HOGENOM" id="CLU_792359_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="326" mass="36064" checksum="C2040ED0E25C2234" modified="2013-09-18" version="1">MSAYNPVKDLGLTCPYGGIFYICADDPDRFIGCCTINPCGTRKGLCPDQSLRSASFNATLQHEFLPQACINDNVDVSWYTCVGEGLPFLGCCAVDPCFRGVCPQRDLRAAKLSDKAKNAQDFLHGDPEYMPRPTSSTLDQGSGVSSGSLCASSTTAMMTMISSFITSFAMETTIATITSTTTMTISPPEAPDAPPAVPKEHGSNRRLGWLSLLVVPIVLFLLLYLANRFREKLPCLKGREKSPKGKLEPRREQRHEQEQQHEKQQQQQKEHEHSANTAPYPENCQMPSAENPRNMREHSVMNISRRTHEQPQNIQGQLQGNGSSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC95</accession>
    <name>S0EC95_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_12381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434582.1">
        <property type="nucleotide sequence ID" value="XM_023581980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC95"/>
    <dbReference type="STRING" id="1279085.S0EC95"/>
    <dbReference type="GeneID" id="35405837"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12381"/>
    <dbReference type="HOGENOM" id="CLU_018150_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT72504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="573" mass="61178" checksum="CAF1920B5DD4C556" modified="2013-09-18" version="1">MPEYRHARSGSLSVANGGSHSQASAMANTPRFDGPRSPPNTSHVPCKFFRQGACQAGNACPFSHDLSNAAENVCKYFAKGNCKFGPKCANIHILPDGRRINYGKNGVTIGNTSALAGRSNPTSASNNQSSTSALTTSLYRADVPAYTSAYPYDEQDQHTLGRQPSLENGLPTIDMSYTGSNYGSPRDEESLRFGMGLSPINNKGLSVLDAPLPASFDSNGISNAARFPAGPWPSSVPNQFGIESPTPSLSNAKDSRTSETLKLLHTSAFGSSEHLLAPLDRSPPNSHQANGEEYFGRRAMHSSRFTKPRMLSSSMPKTSVDRDWEPGFAFGDDDDNLPENYVPENLQDLLTPVEKARRGSMRADSDVEGLSKYGSPIGTSPSRWGPMFQRQKEEEETSRSLRGASAFGHVGSPLRNSVLSQEMGGTNGFVRPSSLRSGSDGMSMLSQQLQRSRLDDTAGNSSPLLHPAAARAGTTASAISPISPIGKERERGGMERHVSSGSISSSMNGRFTTPINEDDEMFHMEGMEEDGEPSIKSPKRTSAGLANVWSSYAGAVAGKPSTNGTKGVPVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECC4</accession>
    <name>S0ECC4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434669.1">
        <property type="nucleotide sequence ID" value="XM_023582081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECC4"/>
    <dbReference type="GeneID" id="35405927"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12471"/>
    <dbReference type="HOGENOM" id="CLU_061841_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="345" mass="38576" checksum="C3C2F7CA40222291" modified="2013-09-18" version="1">MRADNISMQGGGYYNENSTLQGQAIEKSLELLDPSANRGPSITLADYGSSEGKNSVRLFSQYLERIPSVASATLIFNDTPSNDISSLTSTIHQNWDILSQNGKVSINSLLSPRSYFEQVLPDGFVDAAFNFTALHWLRSMPDASSTPSSLSTAAHVDFVDFLLVRHKEIRPHGTLTICVPSDGDISVLPTFRCFETSLRSLHDKYQVDPMIARRLPMYFRTSEEILTSIAAVDKKWGLRSLHTLPLMHTSWSPEVIEASSDEFKAAARKRYTDAVAGFALAACSQFFIDGLKPQGHRGSRPEEEAIRLKEEFMTDLTTTFKNEFLLTHCMDKVGFTYTLLELERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECL8</accession>
    <name>S0ECL8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable RPN7-subunit of the regulatory particle of the proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432202.1">
        <property type="nucleotide sequence ID" value="XM_023579350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECL8"/>
    <dbReference type="STRING" id="1279085.S0ECL8"/>
    <dbReference type="GeneID" id="35399544"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06067"/>
    <dbReference type="HOGENOM" id="CLU_031814_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000013">
        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="229"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="487" mass="53715" checksum="D3335B6004A0AB28" modified="2013-09-18" version="1">MGSDPQYAKWPLLPLSQHVFTLTNGYATKNAQQAAVKALQDAIAQDKMAPFYRYLAHPLDGVLNTLGEGGSSAPGRPLSRKSSLVGMIATKPAATIVSLPWDEGLYNQLKEDNDRELQEFQKEEDDAVEQAGDTEVMAAQGKRAEFWARVGDKDKAIAAYESLSEKTGILGTKIDVVLAIIRMGLFYGDKPLVKKHVERAKTLVESGGDWDRRNRLKAYEGLHLLTLRSYNLAAPLLLDSLSTFTSYELCTYSNLVVYSVLAGSVSLKRVDFKSKVVDAPEIKAILGDGEDKLLALSGALSAGPGADDTTGAKAPKTATAAVNLTTLGTSTEQPEAEMAIDFSPLALLVSSLYSGNYKTFFKSLAEVEEQFLNQDRYLHEHKNWFIREMRLRAYQQLLQSYRVVGLESMANDFGVTVDFLDRDLARFIAAGRIPCTIDRVTGKGVIETNRPDDKNKQYQDVVRQGDQLITKLQKYGQAVRLRGSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECR7</accession>
    <name>S0ECR7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434752.1">
        <property type="nucleotide sequence ID" value="XM_023582184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECR7"/>
    <dbReference type="GeneID" id="35406019"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12563"/>
    <dbReference type="HOGENOM" id="CLU_115939_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="205" mass="23023" checksum="4DC7D7DF51E36D36" modified="2013-09-18" version="1">MSDHLSVEDIDDAELPGALQRLDNTQLNRTVQGLDSNQIPRILLATKSMNDEHAQRIIQSLDPSTDNRIQTFGGMMFWGTNIQSGPGNPGHPTFCDKFPHKTGTGRFVCGCGWHDSDQAVDDLIVHYFLLKQNGILWSHVEGAPNEYMCRACFNDKPGSFNKYDLNDLNAHISKNHVINPYTLDASLKGSYGQYLGQRPGYYYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED50</accession>
    <name>S0ED50_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7908 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434944.1">
        <property type="nucleotide sequence ID" value="XM_023582404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED50"/>
    <dbReference type="STRING" id="1279085.S0ED50"/>
    <dbReference type="GeneID" id="35406216"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12760"/>
    <dbReference type="HOGENOM" id="CLU_729671_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7908" evidence="2">
        <location>
            <begin position="83"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="379" mass="40117" checksum="74F3A7C11E61407A" modified="2013-09-18" version="1">MSYFTSVFGRQTNESKTESVASLIDEEILQLAESISESASVAVELSTEESPVTQSAFQTSFGQTTLVSFTTTGIIEPGGQIVIFLIQLPDDDRKRSINKREVGGFVGDGSPDTCTFASTFNLAQGQLFKNDNPLFYSGEDFKELVNQGMPPSDAITKGFASTGTSLTFQNDDLPNGQAGFCQTSDGQVYITFTSKPPGCTPITLGVHDGMPLRFSRCQNGILSGVDHNSSSSTTTATQETIILSEKATTLSSELVESSNSSLRVTTIQPDLTSSYETPSSIDDVASTTSLVTDDPTSDSSTSDSSSSELAESITVSDSTSPTLATLEAFSVQIMIESVGDIVEEITSIEATTEVSTAADEAAVKTTTTQKLQLQQSTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED64</accession>
    <name>S0ED64_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable alpha-N-arabinofuranosidase / alpha-L-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434907.1">
        <property type="nucleotide sequence ID" value="XM_023582362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED64"/>
    <dbReference type="STRING" id="1279085.S0ED64"/>
    <dbReference type="GeneID" id="35406178"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12722"/>
    <dbReference type="HOGENOM" id="CLU_009397_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18619">
        <property type="entry name" value="GH43_CoXyl43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495838" evidence="7">
        <location>
            <begin position="21"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT72829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="350" mass="39624" checksum="405B07544DF71CF4" modified="2013-09-18" version="1">MQLKFLSSALLLSLTSKCAAQDTNDIPPLITDLWSADPSAHVFEGKLWVYPSHDIEANVVNGTGGAQYAMRDYHTYSMKSIYGKDPVIDHGVALSVDDVPWAKQQMWAPDAAYKNGKYYLYFPAKDKDEIFRIGVAVSNKPSGPFKADKSWIPGTYSIDPASYVDTDNEAYLIWGGIWGGQLQAWQDKKNFNESWIGDKAAPNGTNALSPQIAKLSKDMHKITETPRDLVILAPETGKPLQAEDNKRRFFEGPWVHKRGKLYYLMYSTGDTHFLVYATSKNIYGPYTYQGKILDPVDGWTTHGSIVEYKGQWWLFFADAHTSGKDYLRQVKARKIWYDKDGKILLNRPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED65</accession>
    <name>S0ED65_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable argonaute like post-transcriptional gene silencing protein QDE-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432417.1">
        <property type="nucleotide sequence ID" value="XM_023579613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED65"/>
    <dbReference type="STRING" id="1279085.S0ED65"/>
    <dbReference type="GeneID" id="35399780"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06303"/>
    <dbReference type="HOGENOM" id="CLU_004544_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="716"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1063" mass="117133" checksum="659964ED9EC88E41" modified="2013-09-18" version="1">MADRGGRGGRGRGGRGGGPQDGRGGGRGGPSGFSDSRGGRGRGDGYQGRGRGDGGRGDFRGGFSGPRGGRGGYDRGRGGPRGGRGGRGGYSSQPEGPAVFTTGGSIPQPDGDIAKLEDEVVRSNATSVAQLTSNMGKLTMEDKQNLGKFPPRPAFGSKGTPVILWANYYAVKTQAPALYKYTMTVKEIVPEGQEEAKERAPKTKGKGGKPGKPRESGPREVKGRKLYLVIKEALNELSKKDKNLLVATEFKSQLISLRKLNLEQDNTIRFNMPSSEGSEKTDVFEVVFNGPVEARVDDMLKYVYSKTGASDDGSDPSQAMTYPKFPDVIDALNVIFGFGPRSKLDEISAVGSSRFFAFGSDNRRNEVVLGRDRALKAARGYFQSVRLSTGRLLLNVNVTHGVFKIDGPCAKFFEGFGVTATQSPLMARKLKLLGRFLPKTRVWIKTKYGSKEVRRSKAIHGLVSIRDIKKQCRDKNPPKFRHTTDFAVGPGDVSFWLEDEGKGRYITVADFYKQKYNVNLQNYPLFNVGTAARPTFVPAEFLEIQPGQSVKAKLNGAESTDMVNFACRTPYANALSITTDARQTLGLDDDILGHFGIQVGRQLLTVQGRVLTVPRVAYLDQQRRTKAIDPRNGSWNLRDVKVVKPGQLVKKWSYVNLLSNSKSEPVAAQSVLAFSQFMKKTMNIAVNDPIPPPFLAADSQDAEKVLGWAQKNQIEIMLVILDSTGSELYGKIKTLGDCTYGVHTICVQGFQLRKENPQYFANVALKWNLKTGGVNHKLLNEVGLIKEGKTMVVGYDVTHPTNMSADKSDAAPSLVGLVATIDRDMGQWPAYSWEQSSKQEMLDETLTEAFKSRLELWQKHNQQELPDNIVIFRDGVSTGQFAQVLRAELPRIRIACNGKYPKNKAPKISIIVSVKRHQTRFYPTSEENAMEKNHNIQNGTVVDRGITEARYWDFYLTAHASIKGTARPAHYTVLLDEIFQAKFKNEAANELEKFTHELCYLFGRATKAVSICPPAYYADIVCTRARAHRPEFFEETDGESVISAGSAGNKAVHPRLISSMYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEN4</accession>
    <name>S0EEN4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">H-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435297.1">
        <property type="nucleotide sequence ID" value="XM_023567925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEN4"/>
    <dbReference type="STRING" id="1279085.S0EEN4"/>
    <dbReference type="GeneID" id="35403566"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10099"/>
    <dbReference type="HOGENOM" id="CLU_529970_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098636">
        <property type="term" value="C:protein complex involved in cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046871">
        <property type="term" value="F:N-acetylgalactosamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052487">
        <property type="entry name" value="Galactose-binding_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037221">
        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019019">
        <property type="entry name" value="H-type_lectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46938">
        <property type="entry name" value="DISCOIDIN-1 SUBUNIT A-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09458">
        <property type="entry name" value="H_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141086">
        <property type="entry name" value="Agglutinin HPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H-type lectin" evidence="1">
        <location>
            <begin position="349"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="508" mass="56531" checksum="B5E284E9CAA42AC2" modified="2013-09-18" version="1">MATTSAPITHKAPVMFCAPGNPQDPKTSFGGYGDSIDSIVPWPGGSQISIATMSSGAVPSWVLDIMKSVVEEWLRGLGGGLTVEWLPAGSAAKIRISFQNDVPNWSCVGARARLYDQSKPTMNFNFGGWKDDRVVYSHAYTKRLAAHLFGHALGLPHAQVKQTLSYNKPELEKLCGAYYATMIQSATGCQKLQDSSSIMHHDLPSALRSSGADSLHGGRVIDVEARSLLQSLYPLLPKPLCDRFSIRNLNGFKEGLNANGVHKAITSKTNNIVAGLCRLDMGTNGNFRLQSKITDIKKKKEYTWEVGTWADTNLFDASYSILSFEEEDQRVQTGHTEWKYLSGGKSRSTHRSFTKPFRTIPEVIVFITGFDTLKGRNIRISVSASKVDRNGFTVNMETWADSEIYNLTVSWIAHESDEWTIRSGDLTYPVSPFETTRESSRTESFKSPMSRDPLGIFLAFTYIDAPGNCPIRLNLRSEMTQEGVTGVFSTWEEESRFYRCRGCYFAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF39</accession>
    <name>S0EF39_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435467.1">
        <property type="nucleotide sequence ID" value="XM_023568120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF39"/>
    <dbReference type="GeneID" id="35403391"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09924"/>
    <dbReference type="HOGENOM" id="CLU_123441_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="181" mass="20934" checksum="87395446D2E05865" modified="2013-09-18" version="1">MALNSTNVESDPQSSSTPHLELVNGQVPYRDAVVSWKLPKVLLLGEERYISFELDCVKHVVLQISDARQRQVFTQIGVQHDYDYPFPFWHFLGKMISQALLENETSLEILSFTRVNDREFVGFENKNALKSNNSTDLNVIEVSLKRPQANEPMEIFWRPARGIIIQRLRECEYREGYTSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFR1</accession>
    <name>S0EFR1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_08718</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433307.1">
        <property type="nucleotide sequence ID" value="XM_023580548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFR1"/>
    <dbReference type="STRING" id="1279085.S0EFR1"/>
    <dbReference type="GeneID" id="35402194"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08718"/>
    <dbReference type="HOGENOM" id="CLU_011638_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000441">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="51"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="480"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="537"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="820"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="949"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT71228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1010" mass="110943" checksum="EDBEA22C3C8C741A" modified="2013-09-18" version="1">MASHGQYPPAHMMPNKHHHHAPYGSPAAIPGGAPAGTFAPGTKIQVGSHRVVIQKYLSEGGFAHVYLVKLAKPVDGTDQAVLKRVAVPDKDTLRGMRIEVETMKRLKGHRPIVTYIDSHASELQGGGYEVFLLMEFCNGGGLIDFMNTRLQHRLTEPEILNIFTDIAEGVACMHYLKPPLLHRDIKVENVLITARGSSKRFKLCDFGSAASPRPAPTTVTECRLMDEDVQKHTTMQYRSPEMIDVYRKQPINEKSDIWALGVLLYKLCYYTTPFEDQGQLAILNASYRFPSHPVFSDRLKKLIASMLRENLQDRPNIFQVLKEGCAMQGRDVPVQDIYSRSQPHARTDSPQPKAPKPEQTPAVGAVFTRAEPQKQVIPDVVPMRRGRPAASPAPAKVVQKPDASPMRKTEGDPFAALDSKAASKGFDELSSRFPTLDQFSLLHDQGTKFDFDVSSPVSPTGNTSSDLNERVTAKLADEAFAAPQTESPRPKPVSRTHSVTPVGHHAAVASPPLEPPLAKTLSAPSRPDISRAQSIISNNPELQAISSQSNSRYVSTGTMTSTPPPEKFSRDVERPVQREIAEYSRSSSATRQVDPSAAQWNAEEPRAAVSQRISAFQQPSHERQPSSSRPSLEGGRPRADFLEPAARASPAPSRPRPASTNLEGTTLDFLREREAASRSSSRPPQSRSPYQEPADEPRTSSDMEFLRSLEDSERTKSSKRSSLTSLSGNKNILAGKFGDAFKRFEGSSPNNGRIPSPERDMARRDLTPIAGSEATDGRSDDGHFHDDEDRMTPEMRREMERLKLQEEEQRVEAAQAEYRKRVAAGQRGPPVPPKSIGGVSRAVSIQNRVQSLLNEDQKPSSIQRTAQGYGKYTDVPETGNKPEKSLPGVPKKPLMVAKTRIDSPQARGPSSTSSAPPALTSKPPAKPPAPKKPVHLNSLPTGPRPSSPQKPTRAQTSTEELIEFPGQQMVDMTAKEKDDYIQDFSKRFPSLGSIEMVEREIGGQNGGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFS5</accession>
    <name>S0EFS5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435667.1">
        <property type="nucleotide sequence ID" value="XM_023568472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFS5"/>
    <dbReference type="STRING" id="1279085.S0EFS5"/>
    <dbReference type="GeneID" id="35403074"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09606"/>
    <dbReference type="HOGENOM" id="CLU_1360269_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF84">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27233" checksum="3127A2B56A85D8BA" modified="2013-09-18" version="1">MASAPQIPPIAIFPSIFQTTHSALAFMMASDFEKQSYWHKRFSSEKAFEWLLPSTDFMPLVKPVLDRLDPATARILHIGFGTSDLQNHFRSRGFRDILNVDYEPLAIDRGRDLEEQAFGDIQMRYDVQDATQLDLCEKFDLIVDKSTVDAISCGGEMALRRMAAGIKRCLADGGVWISFSYSAYRFDLDDLPFDVEVLAKVLTQKTLPNDPDIYHWCYLLRPKPDTAPGSPISTDDSPAGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFY5</accession>
    <name>S0EFY5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435752.1">
        <property type="nucleotide sequence ID" value="XM_023568575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFY5"/>
    <dbReference type="GeneID" id="35402982"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09514"/>
    <dbReference type="HOGENOM" id="CLU_032737_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="601" mass="66603" checksum="E3BA0F221329A67E" modified="2013-09-18" version="1">MPRRWFSDRLHDAWGRVAGRRGRQRDQESQSSQHYAEIVAAPDESLDRANHLHLRRGASLPDLLARAALGHIPPPLPLDSQSLWDTPAPALSPVQSQSSGAIGFGTFLGECEREASREDQHFIPTAIITTRNTVSIGQGTENQPWMLPGHDFFPESQPLVPSHLRTGLFLNSQLEHRTLEPCDCCSPKFLVGDWRALTLDPLTNTFTRHESLASSSELRSRDHPKSQDKAFAIPINVITIHSDVFALLLEVLVSPNGLIGQEDELNLPLLLSTLSYALDQGMTRETKKLKRTIDRYIPLRMFHHNPHTKSPRLEFEYYEFRSEEVYRAWLVVSQDVRLRDYLSPSEVVTLYVCLVPDWCWSGCIHDYDERFIDDTNTALASIKGDPGSRFEQVFQGFFNRTRLGLHSWTGSDALSGGGQVSVTKTESHEEALQAFGNQPQVQTDSALTLYGVPFQGTRKVQHRNHPPLSGGDLEETLRGFQGGARRVLDALFPGAGRGSNNSQTPGAQDVPITGALESVQGNRHQSVLDALFTGGTGEVADGSVEDGGFNGMPEGSDYDQMRGDQDIPCVVPPVAVSDTSGSSERGIRRVRRETAVFPRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGL6</accession>
    <name>S0EGL6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_09384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435873.1">
        <property type="nucleotide sequence ID" value="XM_023568720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGL6"/>
    <dbReference type="STRING" id="1279085.S0EGL6"/>
    <dbReference type="GeneID" id="35402852"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09384"/>
    <dbReference type="HOGENOM" id="CLU_1147819_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF10">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YrdC-like" evidence="8">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT73795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="254" mass="28001" checksum="7C45DB8EE3A826E8" modified="2013-09-18" version="1">MISNASDRVTPRPGELPDAKRDALRAFEVLKKGGVIIAPTDVGYGMMAATTDAIERIFIAKKRKAGHSMGVIGTYDLLTRLYDVPDDKYTIVRTFTEELGLTVAFIGKLKESATELIPNVDRVVKNGTLGFAIGEGPFSRELARLNDENGLVIVGSSANLTDQGQKFRVEDIEPEIIEAADLVVNYGRQKWHLYGRAGTILDLNNERVLRIGANYENIREKLIDLFGWTVPEDMDYDMTGKKTVGFSIKAGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGM8</accession>
    <name>S0EGM8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436249.1">
        <property type="nucleotide sequence ID" value="XM_023568969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGM8"/>
    <dbReference type="GeneID" id="35403678"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10213"/>
    <dbReference type="HOGENOM" id="CLU_912166_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485909" evidence="1">
        <location>
            <begin position="22"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="305" mass="33413" checksum="3EF317AC689DA214" modified="2013-09-18" version="1">MKHHSLFGALALASFISFATAKAKGDGYYGYRLNRRGDDESAIYETENTNSGIAPLNEEPDVYLNANVSVGEISIEVQNITAKINLDAKVLNLLNFNAGVDLGIDRVKLGIYNVTAKVELEARLGNILRMVDDVLESIDLNPIIATLGDTVKDIVDDVGDIVGGSSGGNESGEDAEALEKRDLTARLENNILYSVNDFSGSTNRNRVLTQDGFLYDIYLNNNGVERRRKEVGFYNKDMKFTGHNKTITGDEGVEYELQYTYAPYHGLSAYCNIYTDQSGKVLRTKIVAEAEGGGAATIVNKEEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGW2</accession>
    <name>S0EGW2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436092.1">
        <property type="nucleotide sequence ID" value="XM_023568165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGW2"/>
    <dbReference type="STRING" id="1279085.S0EGW2"/>
    <dbReference type="GeneID" id="35403350"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09883"/>
    <dbReference type="HOGENOM" id="CLU_034018_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF1">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="251"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="630" mass="70689" checksum="E5F5C0C71A8C112D" modified="2013-09-18" version="1">MLSAEPSSSPIAALAVDGGHVDALHKGKTESIQIPHVKTTEKDDESIASGSTDSQSQLKKRLSADMSKEQVEDLVRKLTIDEMKTRWFDEIFEKVKSELVEEHSPADTPSSSEPSSPRSHPAKPASHESTPQEPPKKHESASSSFDSKNKSHSNPSSSRSSLGSPTTSYISDSASSRASNRPSSPPKPAIKESSPPAPKPRPCVRFSKAPIILNEGPEPRHPEPRPTSRSVPPPEPVKQGPALSAVDLKWGTLFDDKGEPTKRLGQVLRGIANYLISEYSPHNSLVVTPEKLNAFYLEYKLDTETFPFQQIFDCRPHGALDNLETLYQHLRCENHLIQRRPGGMPHIPSLTPAGFERWMTCQLRAFPDQEAERLNHIMTDLPITADGVLVDDKPERLPKQISRHLLPATRHRETHELVVDAIAGWIKHTEENETDYRRTSSEDVYKIKEEKSGRYRPDDYREREKYRRGSKDNHRQSPLSSSSRFVSRVGSDSTIRPSKDSPVSSSSSHRARSPVSNRYRHSASAIDSSSNTVDAYDIPSPSHRNSHPTSSSRRSRDKEYRYSSSPKSKSPIESTPRTLPRRDADRRSSLIFEETGKDPSGMTYDEYLRMNQRPMRNAVVDDGGHYRTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHI1</accession>
    <name>S0EHI1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436327.1">
        <property type="nucleotide sequence ID" value="XM_023569058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHI1"/>
    <dbReference type="GeneID" id="35403757"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10292"/>
    <dbReference type="HOGENOM" id="CLU_1069950_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485264" evidence="1">
        <location>
            <begin position="17"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="263" mass="28914" checksum="FCCE7B280568A0B1" modified="2013-09-18" version="1">MHSFKIILISLASVLAMPATSPRDIGADEPFDFGQGFLVPANVSIDDYDTTPMIPLPHLSLRDLDSLEEPFAPEIGNITDFDLDTRAPKETRVFFGKTQVDYGCEASIRNPLGTAIHSICGNGDCDKSVVYTRKVKHMAGGGRRKDAWLRISVRGEYYGRHTRGYMASAVQRSVTPKTAKPAMRYYLPTNPNFQAQSCKMSKFSNYIKMRKNFGDTIYMEIDITLKTSNTHCFTPNVLKEVAGAVGGVGGSFFGSVLTGMLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHW6</accession>
    <name>S0EHW6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF3328 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436462.1">
        <property type="nucleotide sequence ID" value="XM_023569216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHW6"/>
    <dbReference type="STRING" id="1279085.S0EHW6"/>
    <dbReference type="GeneID" id="35403897"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10432"/>
    <dbReference type="HOGENOM" id="CLU_042941_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="30109" checksum="C7B405B90194D957" modified="2013-09-18" version="1">MSLPEVGDCGLVNDACSSEEELFLPKLSNGIQARKKHGSIYCLLYLCILFIISLLCLSTYLALSLKESYHSNVVFKDHVYSPVEELVHYKNLVFTTGFGSERTPYQGPPTPERDALWDDLYLNFGISRIPRDSAAKLMNKTLPIPGEPGQYVIELNVFHQLHCLNMIRKRLYIEDGKYDPNHKLTGIEHLEHCYDALRQSLMCSADITPLPWVRSDKAQEAKEVARVMHTCRDFDILRNWAREHAVHHFDKKTHVQDDLSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI68</accession>
    <name>S0EI68_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_13949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434131.1">
        <property type="nucleotide sequence ID" value="XM_023581432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI68"/>
    <dbReference type="STRING" id="1279085.S0EI68"/>
    <dbReference type="GeneID" id="35407403"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13949"/>
    <dbReference type="HOGENOM" id="CLU_029797_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="348" mass="37485" checksum="81A9942853B1D6E4" modified="2013-09-18" version="1">MWLLLSTAAVNGSDHIAHGSPGAPTSFEDFYSTDAPQFSLHVATFQDGTLVSLTFMHMTTDLGGLSSVLEAWCSILAGKPEQVAKFPGYNDVMAGLYRAETTEKSKTDGSLLSGWRLVVWALRAAYDGWMYPLESRMLRVPAKAINAIVAEARSEISLEKTTDGSKPFVSENDVILALCNRSVAKSMGRGRAIVTLIAVNPRDRLKNIFLPDSAYVQNAPCGAFFYCPVRDAQDLPLGKVAMLSRQAVVEYLTEGQIKAAAKAAYVSMIEGGNPPIVGDTTSTMIMSSNWAKSGFLDKTDFGPALTPIIFPVSVGINMGRDGDGNLWLGGDLSAASWATLMGYLKLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI98</accession>
    <name>S0EI98_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435620.1">
        <property type="nucleotide sequence ID" value="XM_023568417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI98"/>
    <dbReference type="STRING" id="1279085.S0EI98"/>
    <dbReference type="GeneID" id="35403123"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09655"/>
    <dbReference type="HOGENOM" id="CLU_008719_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="428" mass="47941" checksum="C9D495EF1DDB2B9A" modified="2013-09-18" version="1">MPRPTKKGICNTCRRRKIKSGNQALPICGQCTTSGLYCDRSKKPTHFIHHQELPNPDSPRTALQDQNIARLFHAYTSTISEWYDLSDSACSFGLEVPSIALDEPLLFCAVIALSSMHACKTSAPSFRKVAEFYHHRCVQFLIALDSGDELIGRGVALAATCLLRSYEILDGDVDPNMHLRGAYSMASLHDVLSGIPQAGLLGAGFWNYLREDITFSLFEECPLKMDLESTPLTIQHSSDQDYLNSITLILGKIINMSFKQNTDGRQWDYIKEDLKSWRNSCPRHMEPYSRLQGESTASRLFPAIWFLQPCHAAILHYYLVAMTIVCIYTSPRSLEDLGGLHLPGLEVQSKEMFLEYFALEICGIAFTAKVPSVLVNAFGPIAFCARFIKAEASQQELIRQLLACKSTIGWPVERLIGDLKGSWGMDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ07</accession>
    <name>S0EJ07_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436673.1">
        <property type="nucleotide sequence ID" value="XM_023569459.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EJ07"/>
    <dbReference type="GeneID" id="35404115"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10651"/>
    <dbReference type="HOGENOM" id="CLU_003445_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1616"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1713"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="954"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1390"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1617"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1723"/>
            <end position="1733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1746" mass="191440" checksum="9A5DE62EBA2C6634" modified="2013-09-18" version="1">MPILIKPRRLQELEAKSDELHQELGEVDSDDEDSEAQRQAKQESLVALERELRPLKTDWDRTCRDAHVAYRPEDEMKANSLMNNLFNLYKDFGLPINGNMAVDTSALGLPGDSPDADPDTPRRPRMRVKRGGAVLTPDRNGVFEVRFPFIAVFALLCLRALTLISNTRKRKRGRSSAISHKRPRIQGNRNSIHFNAVYQNRRAAKKHTIIRVPEDEDPVRPAKFYILRCEHHDIDFNDNPLQAGLAHLSEAHQHENPSFETVVQHFGYELIGCDDEKLIQNNKAAKESFQKGERGARDFIRVTDSPSPNTSRKKTSNAAKKGRSSRKSRHTINPRDLVPGDVYIIYWSSSKQWYCGLHIPLQDPESVGIDESLEALGLLNNIPPCYEYDSSSKSFSWAEGYEDGGEDASEQQFPFMFFEGLDFPDLCHVAWIPLDEIQPWDEEKALVIEHSDQAFEYIKRREAAQQPKRLGPNDEIPDSADDNSTSDLAPRSPVAESSTDFQPAQNAGTVTPNTALEADAADEAKIADVTGLTEETLKDTKGTPEEEQNIQPEPETQKNIEAAPVEEREILAEPEEAQSTHMETEEAQDTGLESEEEQDILTEPEEVQNDTTLKSGELQNDAALEPGEVQKDTQMEVEEAQETGPEPEKVAESPVQPVIVEDEDITMSSEESSTESTAQRPTEDSEDVVMETPEDATQEPLQQNDSQSYGADQEIVFETQEDPAENVSSPKEPKEVTAEREQESSSDEAREERLPSVDLEDLLTAGEDLEFQFSQSEQRELSQKPAPPPSREAVSLSNAPNDVVNTKQEESLPASPTPETTSVTRMETDSGDETREASQAQRSSVATESSNDETPRPRLSYAEMGRASSLSEGVPSDVVESRPQIQPASRRARSGTPNRNALAAQSRMSSLSKSPVVSRPPAMSPPATIPFSPTAPSASNPLQLPRMSQPPPSSQSSVIRSPTSQRPPSGLQHPVSSWPLDNSWASTTPQRLGSSQSSALARRPAPSQPMAASQPPQSSQPPARPSALSHPTSSSQQSPSGPPFRALIAQMGPAAQVAMSPGPAVSNGEQPHNVRPTSQTSQVLAPPRHSQVESPLPEDAQNRSEVLRHPHAAQPRASAQALGNSPGSKEPLRAIKPKAPSKPTVEIVLLNRQAVNEARLQSMTTGQPAAAVASPTQMAAAHERHSEPAHITPTPPVMSAARPIAPAARRPLPHERPSPRPSASPVKSREASKAKPSQNQAPSASSQHSSGAENTPAAQAERPAQTISGQPPARYASRPTSPVHQNSPRLPPMNVPQEGHYLPNTMLAQQQASLSRPSSSGNVGPQPMPSPRLAARSISRPGSASQMHIRSQAMPSPHQLAAEVQRPQSSFQGHPGSQPMYSPRQVPGEIPRHASGYERHPNHRPAPSPRRPYAVPVQPPPSPHQPFSRFPHQSPEMQGQGYVSQRHASTGTLSPQASTAENQLPPIRLPNISRPRSEAHTTPNMISPPQTAVGARPGHYTGHQQPTPAIMQSPRLSATQISRPHTASNMRPPLATMSPILGHAEPRRPNSSYTQAMPFHAPLPTMLPNYSSTGYQSSAPSAHQYAQPNRPQGHLRRHSESACQPQLQQYALAGSPQIANSTPRSYQSHELDQGPRRNPALDPFLSELSPNVRKALLEQVGTERPDLVPCDFLNNENRYRCPFCKESTLEPTALVDHIKMSCPKLEEKYKQDKNEQAFEANRGKRVKPAKRKSQMAQAAKNARVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJC8</accession>
    <name>S0EJC8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to HNM1-Choline permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436823.1">
        <property type="nucleotide sequence ID" value="XM_023569636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJC8"/>
    <dbReference type="STRING" id="1279085.S0EJC8"/>
    <dbReference type="GeneID" id="35404275"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10811"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF11">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="506" mass="54647" checksum="1788096BAB59424D" modified="2013-09-18" version="1">MTEKHEIPDNASLTPSQAAGKTFATHHLHGGEQLEKRYSPLSVLAFAFTTTNSWMAFASGIAIPLACGGGPSIIYGLIAGGVIMATINIGFAELASAFPSAGGQYHIVFMAFPASTRRVAAFYTGWISIIYLMAATASCNFFAASSVLDLVQLWHPSYNIQAWHTYLMHILLCIIAFAATSRFPAAIGRLTTTIFWLSLVGFIASMVTLLAVSDHKQSASTVFKDYKNVSGWGDGWAMITSITACLWAYSGVDGPTHLAEEVPNPSKNVPRAIFLTIGLGISTVVAWTIALMFSIKDVDAIIESTVPILEVYNQALNNRVATTIWSVYYIVMFYDIVLNLFIFSGRTIWSFSRDGGVPFSAFLSHLNWASPVRATAVMLALQIIIGVLYVASSTAYNSFIGLTLFALNITVTLPQAALLVRGRSCLPERSFSLGKAGYAVNTAATLFVALFSVSFCFPAFMPVTASSMNYLIVVMAVGLVFTTALWFGGLRKTFTGPQISLEGEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJH6</accession>
    <name>S0EJH6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to UDP-N-acetyl-D-mannosamine 6-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_11013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437017.1">
        <property type="nucleotide sequence ID" value="XM_023569861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJH6"/>
    <dbReference type="STRING" id="1279085.S0EJH6"/>
    <dbReference type="GeneID" id="35404477"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11013"/>
    <dbReference type="HOGENOM" id="CLU_023810_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491:SF2">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase N-terminal" evidence="5">
        <location>
            <begin position="50"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase dimerisation" evidence="4">
        <location>
            <begin position="226"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT74939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="437" mass="47884" checksum="02904BEDBE411D63" modified="2013-09-18" version="1">MPIVANLVQRPAPRSKVLAHHTKTKQNHAAKTSPAKPIMAPTEATPLVAVIGVGFVGTGLVDSFSSKYEIMGFDISEDRLEFLRGEFSARPNVSFTSKESDLGKATHFLISVPTLLRSDRTIDLSYLRSALRRVEQWARPGCTVVIESSVSVGLTRELLGPIAKAKGLFAGMSPERIDPGRVEPPMRSIPKVVSGLDDVIPGSLDAVVRLYGRVFDSIVPVSKPEVAEMCKLYENCQRMMCIAYANEMADACKGLGIDAFEVSRAAATKPFGYMPYTPSLGVGGHCIPVNPYYLLSNCEFPLLEACADKMNKRPATQAQKIVDELRGTSKTKRRDSGIDLSKRILVVGMGFKAGQDHLVNSPGLQLAKELQKLSMDVTFADSLVKQTAVPDIPRLADEDWTKEELESFDMIVVSFKQWGMDFDVLDGVSVPVQMWCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK42</accession>
    <name>S0EK42_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">FFUJ_10295</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436330.1">
        <property type="nucleotide sequence ID" value="XM_023569061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK42"/>
    <dbReference type="STRING" id="1279085.S0EK42"/>
    <dbReference type="GeneID" id="35403760"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10295"/>
    <dbReference type="HOGENOM" id="CLU_028820_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496069" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="23">
        <location>
            <begin position="24"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CCT74252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="302" mass="33472" checksum="2F702F2D8700C423" modified="2013-09-18" version="1">MKLFGSIGAVAAALMLLPGQALAGQYKGFSMGANRADGACKYTADWKKDFQTIKSWNKGFNAVRLYSADDCNTLVKAVPAAKQTGMKILVGVWATDDAHFGRDKAALLKVIKQYGTDWIAAISVGSEDLYRKDISPDKLAQQIYDVRGMVRQFNKNLKVGHTDTWTAWVDGRNDVVTKACDIAITNGFPYWQGVAIKEALQKKTFQNSYWSVQKHVKAVNSKAAVWVGETGWPTKGPNYQKAAATTASLQSYYNNVGCWLWQQKDASGFWFTAFDAPLATPEVEKYFGIANKDRKLKFTLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKB0</accession>
    <name>S0EKB0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to diaminopropionate ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436405.1">
        <property type="nucleotide sequence ID" value="XM_023569151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKB0"/>
    <dbReference type="STRING" id="1279085.S0EKB0"/>
    <dbReference type="GeneID" id="35403840"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10375"/>
    <dbReference type="HOGENOM" id="CLU_021802_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05652">
        <property type="entry name" value="M20_ArgE_DapE-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="190"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="377" mass="40469" checksum="FC44C53DD11ED51F" modified="2013-09-18" version="1">MKLNSIVFSAAAAAAFNLGNVQFPFSHESLESSPLLDLHKSLVERPSITGSEKHVTDFLKAYLQDAGFTVEAQSVAKNRDNILAYYNNTRNTRVLVTSHIDTVPPFWPYERRGDEIWGRGTVDAKGSVAAQIIAVEELFEKKKVSEGDVALLFVVGEETGGPGMGNVNDLGLSWESVIFGEPTELKLARGHKGGLGFTIKANGKAGHSGYPETGSNAIDSLVRGLAALQKVELPGSKEFGNTTLNVGRIEGGVAGNVIPANAYATGGVRVAGGTPEGIRDLIRRVVEESDPSLVVEFSYGIGPVPTDYDVDGFETVVLNYGTDIPRLKGSHKRYLYGPGSILEAHSAHEHLRVSDLQKAVEGYKKLISHALDQPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKX2</accession>
    <name>S0EKX2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">M6 metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437338.1">
        <property type="nucleotide sequence ID" value="XM_023570190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKX2"/>
    <dbReference type="GeneID" id="35404769"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11307"/>
    <dbReference type="HOGENOM" id="CLU_038711_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775:SF1">
        <property type="entry name" value="PEPTIDASE M6-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004486014" description="M6 metalloprotease" evidence="1">
        <location>
            <begin position="17"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="43242" checksum="FAF22A21EBD4EFD5" modified="2013-09-18" version="1">MNFLFFSLLWPAVASAAACKPTPPKSKAACKLAANNTVEMSVGFDYNGDCAPSTGTLKGFMIFVDFSDAEPAQDETPQSLYDAIVPQTTEWYSQASYGALSLNVSADMSKFYRMPKSAASYSWERGLTGPEHQEYIQDALDAYTTNGTRPPPSQSDVLYVVPVKSVGSRGISRSITFVSRANTRQGDYVARKTVTVGTDAFTGWGTKSWKVLAHETGHTMCLADLYPFEDLGLGYYVGGWSAMGDLSGIAPDFFAWDKWRLGWINDKSVDCVSERGTTQHTLSPLELNISDNGAKAVVVAVNHTSALVAEARIPEGLDSEICAPGVLLYTVDTSVKTGYGPIRVIDVTPESGGCGAGNVYDKNDGTLSQGGVSVYKVPGWGIQITLVKQTAKSYSIRVDAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELI4</accession>
    <name>S0ELI4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437949.1">
        <property type="nucleotide sequence ID" value="XM_023570905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELI4"/>
    <dbReference type="STRING" id="1279085.S0ELI4"/>
    <dbReference type="GeneID" id="35405409"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11949"/>
    <dbReference type="HOGENOM" id="CLU_007898_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1203" mass="135216" checksum="D4B6AC9C8F64E1A2" modified="2013-09-18" version="1">MVIFTGGKSVAINSPRHLTIRHARNAVQSTRKAEALENEALDITSLEPSAGEPIEDPTPPLEPGQAQLHSYWAPGLEAGKKHEISVVQDIKAPTDKRTLRLKAKQNFYVDAPQFVLPEGSVYSFYPPQGYPDDRRILPHIVLSDPHLPWERIGSPSAERDSHNKDANRNKVPWLALFTFSHDELLLQPGELGEKKFKQSQAGAVKMTIGDFLKLENIATPIVTDSSKDVTDISAEFIFVKPDLFTSLFSTFDEKNNRQVGKKPNTAQYKYLSHVRKINTKGMAIAGVEDFGIFSCVISNRCGPLNNPTAANISVHLVSIEGVEDMEWPKSGQTRLGLCSLHNWTYTVLPPGQFNVRDAFEHLGRELNVLRPAEAVFKPLQSSGNKVTVRLGDRLKDGYSLVQYRVQTGEKTAALYRGPFTPTRVELNEQLNKCSNSGQDFQILDKKVGLMDISYSIAWQIGRTLALGDKAYVAALSRLRSILRTKTMKACKIDAVTEAGTEQSYRSRDDLLKDLPKTIERLHQIQLAIPPASDNDRPHYFAPGGAKKRWYRPELSKRQYPRLGYASKPIQEKYLEAAIEVVLKELSMGKDDQVYDETNDPVSTDWMVVLAWILDRMFLDRIPAHYLISDPSHVPPESLRFFHIDPNWVDAMVDGALSLANHMGQDLDRVAIKHGINRYLEYKSPKLNHRPQVPTYGFYLRSDLVTLYPDLRVNTTGADTGRAPLLRHEIIADGVMLGLFDCIPGQDFKTLNFTQPPHQQRFAAGWYLEADKLEISIGREFTVDPKYQDYSKPEEDWQKVTMLPSSEDNWFTWSTIPKPLVGGKDEGDPGADLRILRLPSFVKKQMDLLNENMGSFTDNEGNKQDYFRDTVPTSALLAMQLNDPYYQLVIALDKQEGSGDQASSSPLANLRSAATGPVQELRSLKFMTPTTVPRVSQPEDDDLDPPEVDTIVSLQAASLDTAAETWERDESFVVRSRTLGHHLPPHHRAPITEHLHGAMGSQAPHGVPVQQLASARRLGAPQVSMFMRTASASSQPSALAGPPIYTCNAYSLQHDVIIQDKDCLPQDIVFSVLVSRNKYSSYQLTEFDIAIELGTSADDNCIMDTYAGPGARMLSNLRFNVLMSFTTMPVTDRKCLLMRLIPRSHKGWIRMQDVHEMSFMLTLAQLNSFAGNKRFSLYTSAYYKFDHEHDPINDFFEVTLQKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELQ2</accession>
    <name>S0ELQ2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_10902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436910.1">
        <property type="nucleotide sequence ID" value="XM_023569738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELQ2"/>
    <dbReference type="STRING" id="1279085.S0ELQ2"/>
    <dbReference type="GeneID" id="35404366"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10902"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="20"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT74832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="319" mass="34459" checksum="48656CE0C3580817" modified="2013-09-18" version="1">MPHFVNTHCIEPHFLRNVLDVLIIGTRTAGLSAAMALGRARRSAIVFGVDDFGGRLHETTSQTISKSIQDETVAEIKAKFKTIMFSRATAASVREKGMVFEVEDVTGRCWKGRKVILAMSSRNVLPDIPGYEEAWGKNIFDVPRCLDVIKVAATHAAVLVTSDSSSSIEAAVLAAHLARQFSPNVTFLTNSLLHVEHHPQIIAGKTCGFKLDNRPIKALESLETSVAVQFTDGAESVYGLIVHKPSKITAGPFSEHLNLESTSEGRIFVENEFQETSTRGVFAVGDSASFLKEESAGASAGWLAGVGANLQIAEDDMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELV5</accession>
    <name>S0ELV5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435456.1">
        <property type="nucleotide sequence ID" value="XM_023568107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELV5"/>
    <dbReference type="GeneID" id="35403402"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09935"/>
    <dbReference type="HOGENOM" id="CLU_133309_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17057" checksum="AC8E741D1DB4DCE5" modified="2013-09-18" version="1">MAPTTTHTARSILESFYDAERIYMASPPDERDFSGMAASLSKEVRLKQSSGLPYAGEYTGPDGFQQWAKAMADYFDKVDVKNPEIFEKEGSNRIISLGYLHLKVRKTGEELKYPLCQVIQVDLEAGVIKSIMPFYWDVYALNKAIGYTPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELY0</accession>
    <name>S0ELY0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylyltransferase AadA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437882.1">
        <property type="nucleotide sequence ID" value="XM_023570827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELY0"/>
    <dbReference type="GeneID" id="35405340"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11880"/>
    <dbReference type="HOGENOM" id="CLU_074146_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05403">
        <property type="entry name" value="NT_KNTase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025184">
        <property type="entry name" value="AadA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13427">
        <property type="entry name" value="AadA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Adenylyltransferase AadA C-terminal" evidence="3">
        <location>
            <begin position="150"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28134" checksum="CAC940DA0A9EF05C" modified="2013-09-18" version="1">MDNLPEDVQRYLDELVKRLTDHLKDQLVGVYLFGSASYDAYQPGLSDLDVQAIVKSPLETSEKEAIIYRLTQQNLPCPATKLEFVVYAQGSVNPANRHPAFELNLNTGPYQSDHISLDPANESSHWFLLDIAMGRQLGRCLYGADLAEAFGAIPRRWVLEGMADSLAWHQANEATSTNSVLNACRSWRYIATGEFCSKLEGANWAMKQDNCPAVIQHAVEGRKTGDKLDAGQVMKLYDVVVKANLGKLETEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELY3</accession>
    <name>S0ELY3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to ferric reductase Fre2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_10991</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436995.1">
        <property type="nucleotide sequence ID" value="XM_023569837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELY3"/>
    <dbReference type="STRING" id="1279085.S0ELY3"/>
    <dbReference type="GeneID" id="35404455"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10991"/>
    <dbReference type="HOGENOM" id="CLU_010365_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004486056" evidence="10">
        <location>
            <begin position="30"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="423"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT74917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="697" mass="77253" checksum="0C91B341E5D7A7F8" modified="2013-09-18" version="1">MNRQWGSGSMALLNSLSLLLALQVSSTYAQGLEGYGLTSYDPVCAEACLRSFTPLMLPCSSMHDGHMATPPACRANDTAFLTSVAWCMSENCGDEKLSKIEGYWEEWITGSKFVPAKWSYSQALMEVDPKPPRYQLNMTDKVLNQTSALPPVAYLSQWNSLWATNHEMIMGARYGIILVVIAVGIPILMTWSGYLPLIPSVYDKLKPYILYPSMIGTYSVRPLPFKLGNAPSVGQGLYIALILALVVVFTAIDYELRQPHARFMGERRELLAYLVYRTGALAFALLPLIILFPSRNNLLLWLSNWSRSTFILLHRWIGRTFALLAVLHAIFVLVGSDKMGTTDWRRWGSVAVIFTVITCLGSGLYVRKANYELFLLMHILIAALVIVGCWYHLMLRYASIRLHSPGYTTGHEIWLYLAIALWGFERLVRIVRVIRLGILRSKVKDIGAGYVRVDVPSVRWGLDPGKHVFVYFPTLAPMRPWENHPFSVIPTVALQRRGTSATPGSPTSPGASSGLEDIEKSTTQIAVVRQSSASAEISAGVTLFIKKSTGITKYLESHDRLLTFLEGPYPGSDTRQVLRCDRLLLIAGGVGITSLFALIHNHWNVKLAWSVKAEARCLVNEIEPGLDAVNTAQTDIRIGSRFDVAALIDEEASAGWKRVGIVVSGPGSLCDDVRAVVSGIGRNSKTVFELEVDAYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM43</accession>
    <name>S0EM43_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437045.1">
        <property type="nucleotide sequence ID" value="XM_023569893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM43"/>
    <dbReference type="GeneID" id="35404505"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11041"/>
    <dbReference type="HOGENOM" id="CLU_014025_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="632" mass="71150" checksum="63923327C80D96F0" modified="2013-09-18" version="1">MAEREEGSPAVEAHGSDEGPPSKRQRGFIARQACEYCRQKKTRCDEDFPCGLCKSLGLQCKFTQRKATRNEASLGMIVNILRRIEGKIDDSKPHDSHSTEHRSIAAALRPFNPRSPANSSEVLGVPSFLRHETIDSPAAPTDPNPAISFSAHQVLFWPAIQSALPESVKLMCQMQGGTYSTRLEASRPKLSHAASVDISSDWLSKLSIATLKQLSDVYFTTFNLANPILDQKTYFQRTLGVAIDGNFGICIESCIVLVVMALGSMGQKALQEAGLAGTPASSPYAGQEGEMPGLDFFNEARKRFGFLMCEQDLQACQFYLLSGLFYAEALRPIDWWAMLSKASACSAYFWNNLSRDRDEWMLDMQSRLFWITSMFEAVLSQELNLPPSNSLHLEEHIALPKFISAQDIASFGSFRYPGDDPFFHYHFLSQLAHRLILTRARNSLFHFNPTADYPPEPVEDELIRQLEQWRERLPPMLQFDPKSPLTQAESPSDALVTAWLHARYFVARYHIGRPLLHRALERPASLTEGHLRKCRDAISAVLAWASVIQVTDTMRSCNPLKFFVCSQIFGQICVIYALSVSPYPYIRDIVSDVNKKWTNFALNYLEAGAFYSPAIEQDFKIAKILYKDIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM69</accession>
    <name>S0EM69_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to ketoreductases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_09716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435561.1">
        <property type="nucleotide sequence ID" value="XM_023568350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM69"/>
    <dbReference type="STRING" id="1279085.S0EM69"/>
    <dbReference type="GeneID" id="35403184"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09716"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05346">
        <property type="entry name" value="SDR_c5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT73483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="271" mass="29061" checksum="2277619398E8A3BF" modified="2013-09-18" version="1">MASAAAKRLTGKTILVTGASSGIGRSTALEFARTAPNNDIRLILTARRVDSLKELAEEIRKEVGDGVKVLPFKLDVSNPAEVNGIVGNLPEEWRNIDVLVNNAGLVKGVARAPEIAVEDINVMFQTNVTGLINMTQAILPIFLARPDGGHGDIINVGSIAGREPYPGGGIYCATKAAVRSFTDSLRKELIASRVRVIEIDPGQVETEFSVVRFYGDKEKADAVYAGCEPLTPDDIAEIIVFTATRRENVVVADTLVFPSHQAGAGIMHRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM88</accession>
    <name>S0EM88_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437987.1">
        <property type="nucleotide sequence ID" value="XM_023570954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM88"/>
    <dbReference type="STRING" id="1279085.S0EM88"/>
    <dbReference type="GeneID" id="35405453"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11993"/>
    <dbReference type="HOGENOM" id="CLU_024469_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="51788" checksum="582D9598B8087CF5" modified="2013-09-18" version="1">MAKHAPLTLGVLGRYYSARHTLGQYRSACVTATYSISFPDDSLLNELNSALEHALQATIREHAGLRYGICDEKVDGVPLFRQIRTFDSQDVMKVVTSRPRAGEGDGMSDELLSRDLESRHSELWPENKPAWRVVVLKHTNNCKSHRSLTMHIAFFAHHAIADGLSGVAFHASLMNDLKLDTPISAKWPLELNEIQDPPPTIEESVDCLSCNCTVCTTPDKSDDPVWAGGPISTAPTENYESLVRIVTVPAAPFSDLLRKCKQANVTVTGLLHAIICTSLRSSIKEDVSGFRAVTPFSARRHTGASDAEIVNHISYLTSYISQQELQRFQNSARGSAAEEQHIIDLARRFSNEVATKVKEFPHGSMATKLSQVQNILQECLSQGGRERRYTYELSNLGLVSSICPPKGSGIKLDRLVFTQCGFVAGPALGFNCVSTRGGNFTISITWQRGIVAESVVEDVAQELETRLGAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMK2</accession>
    <name>S0EMK2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable maltose permease (MalP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438082.1">
        <property type="nucleotide sequence ID" value="XM_023571074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMK2"/>
    <dbReference type="GeneID" id="35405560"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12100"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF57">
        <property type="entry name" value="MALTOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT76036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="548" mass="60557" checksum="2FBDAA195E8C2F5C" modified="2013-09-18" version="1">MAHPSDSKTPIDNPTRVDSHDHVETAFKHDELAAEAVAQGQALSGYENLTFWETVRTFKMASLLCLLAAFSAGADGYQIAMQASIIANKGFVQQFATAVNEEGEKFLASNIIATWSAGQNVGQVLGQIGISFVVARFGRKISMYTLWTILMSSVLAESLARAWPVWFGAKMLAGTGVGCLQATLLGYITEVSPTRVRGGMLMLYSFWWTLGSFCTHVALQRLNKTDPFNWLTPVYTQWGHIGVMAVIYVLLPESPSWCVTVGQEERAKKSIRFIYRGVENFDVNRHYELLALNVEHEKALAAEQRNESWMAIFKGTDGRRTITAMWTIVAQQFLGLALFGSFGTYFFQQAGLADPFQIKAITTSLQIIVVILAVFGVDKFGRRRMACCATSLMWISCLLVGIIGVAPQSGASTSVFVLFACFWNIGISANGAAGWGYIGEISSQRLRPYTSGFAASANSVTGLIMSVLTPYMVNSNKWDWKLKTGFFYAGVGLPWVIGTWLLVPETARRSPAELDELFERKIKAWRFHTTETATQRLMQSENAEAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENU9</accession>
    <name>S0ENU9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_10431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436461.1">
        <property type="nucleotide sequence ID" value="XM_023569215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENU9"/>
    <dbReference type="GeneID" id="35403896"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10431"/>
    <dbReference type="HOGENOM" id="CLU_004965_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="683"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT74383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="782" mass="88269" checksum="257EF68CDD3D3AC6" modified="2013-09-18" version="1">MSISEKETKPESPSSKADIYPADEKRGLPQEDKNVHDIEIMSSDKVKQPLETAEDIVTHVIQVDDDPTMNPWTIRMFAVGIGLSAFGAVLQEIMYFKPQVVYVSVMFLTVLAETLGTGLAHIIPRWGRIGRLLNPGPWNRKEHTAAVLMASAASVSALSTEALTVQKLWYGGYPSVAAGIFVTLSSQLIGYGVAGMMRSVLLYPTKMLYPANLPITTVMETLHKPKSETRKRFQVFWIVFVAIFCWEWFPEYIFPLLSAVSVFCLADRHNPVFTNLFGGSQGNEGMGFLSICFDWNYIAGFGSPLWMPLQTLFNSYLGYIGGIALSMGLYYGNYWRAKDFPFMAQLLYDGASNTTTHIPYNETSIMNPDFTVNNDLVDQQGLPYLTATYINYLITSNAGLTATIVHMLLWNYAEVSLGWNWITLAKLKQLLRPESYKFWKQTGTRSEEEKQKLRDDPTIDPHYKLMLDYDEVPNSWYFVILLCSIVIGLSCLYAMKSTLPWWGFILAILFLIVIMVFFGAQYAITGFGFNLQPIFQMLAGYMFPGRPLANMYFTSYTYNAFSQGTLLLRDLKLAQQNKLSPKATFTTQVIGCVLGALLNYVMMISIVDNQATILMSAEGTNVWSGAQVQQFNTLAIAWSIAPKMFSIGARYEWVTIAYLIGFAAPLPFYFAHKFFPHIRIFSYLNIPIILWYLGYLFVGLNASITSYFILGAFGQFYLRRYRPEWFVKWNYLISAALDGGTQVMVFIATFAVFGGSGKSVPFPAWAGNKVNNYDYCAFNENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP07</accession>
    <name>S0EP07_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_12074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438100.1">
        <property type="nucleotide sequence ID" value="XM_023571045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EP07"/>
    <dbReference type="GeneID" id="35405534"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12074"/>
    <dbReference type="HOGENOM" id="CLU_000022_6_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="5"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="923"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1299"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="923"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1075"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1263"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1379"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1816"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1278"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1391"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1421"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="955"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT76054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2248" mass="248074" checksum="59566489C1A9D377" modified="2013-09-18" version="1">MTLKHEPIAVVGMAIKVAGADDVQEFSQMLRTGKSQHELIGPNRLMMDTLFREEEKDPSRNWYGNFIRDVEAFDHKFFKRSPRESTTMDPQQRLFLQAAYQAVEQSGYFTENDNGGDRDKRHVGVYVGACAADYEHHVACHSANAFTATGNLKSFVPGKVSHYFGWTGPSMTFDTACSASAVAIHTACQNLLSGECSAALAGGIATMSNFLWFQNLAGASFLSPSGQCKPFDDAADGYCRAEGIACVFLKRLSDALKDGNPVFGCISSTAVYQNQNCTPLFVPNSPSLSQLFRDVIAKAGLKPGDISLVEAHGTGTPVGDPAEYESIRLAIGGSNRDTTLPIGSVKGHIGHTEGASGVVSLIKVIVMMQEKYIPPQASFSKMSSHIKVTPYDMMEVVTSLQHWRGDQRAALINNYGASGSNASMVVTQTPATQLVENPAFSSKPVPFRVSGHDGRSIKAFCAKLLSTIEQNPYFDARNLAYNVNRQFNPDLKRRLIFSCRSRDDLVSNLADIASMADDSQAGIENSNVQRPVILCFGGQVSTYVGLDRNVYDGISIVRYHLDQCDARMQSQGFGSIYPGIFLRTPQDTVQLQLMLFAMQYACAMAWLDSGLSSKIVSLTGHSFGEITALCVSGALSLDDAVKLVGSRALAVRDHWGVDHGAMMAVESEESHVLELLAEVNESDGTAEIACHNGPRSFTLAGPTRSIERVAEVIARDARFQSIKFKWLNVTNAFHSSLVDQLIPELESIGRELEFKEPSIPLERATRTRIDSKPDNKFVSEHMRNPVYFNHAIQRLANDYPSAVFIEAGSTSGITMMASRALAGHKDLSSQYFQAINLTSDKALDNLTDATLSLWNQGLSLAFWGHHPSQSGEYTTMMIPPYQFERSKHWLELKSPLQAVNAAAAALGPPQSTTEGNETVRGKTDGLWSLVSGHTDSPVFRINTSSDKYKGFISGHLIAQTAPICPATLMVDMAIEALFSINSEWREKDFLPVIHHMVNHSPLCVNSSLTTYLKFEPLCDQGTHWKWRIYSYESQSDENHAETHVEAEIHIRDPLDRGYQSEFSRFDRLVTHTNCTKMLRLGLGGHQVDWVDVLTGRNIYRTFSDVVDYGDLYRGVRALVGTSTECTGHVVKKSSGNTWLDVPLSDSFSQVGGIWVNCMTDCDPADMFIATGCELSMRSPFVEQDSDQIQESWHVFGRHTRQSEKLWVSDLFIFNASTGLLREVMLGIQYARVGKASMRRMLTRLTTDPSALKLKPATEIIPKPAEPILTPPLSPTHVAQDKGTSKEEGVSIKPKAATHPDITEDVKKLVAHVAGIEAGDITLDAEMADFGIDSLMGMEVAREVQIVFKCTLDQNELMEATSLRKFVVCISKALYGPDYDSTSASGTDDNSESSGRSSASSKGSSLNTPPELDLAQTPPKPSSSMDSKPVSSNLQLSESDVLASFAQVKLLCDEHLVDFKVDNIDREVLAGSSRLCVALVVEAFEQLGVSLTTADPGRVLERIQYPPAHTKLVEFIYKFLSDDARLIDINDATGQITRTQVPTPRRTSSQILDEQLAKYPEFVVANRLTYYAGTHLADVLKGKTDGLRLIFGSIEGRDLVQALYCDHTFNRMNYNHMKLVIENLVERLGNSQPGETLKILEVGAGTGGTTHVLAPMLAKLGIPVEYTFTDISGSMVANARRKFGKSYPFMRFAVHDIETPPAEDLKGQHIIIGSNAVHATRNLVTSASNLRGALRADGFLMILEMTESVPFVDIIFGLLEGWWLFDDGRKHAIITAEEWERNLHNAGYGHVDWTDGSLPENTFQKVIIALASGKPRDRLPKSTLSKASVEESTSEEQERQRELEIERYISKYSAGFEVHNEVQVARPVTRTQNKKAIVLLTGATGSLGSHLASSLASNDHVETVVCINRRSRAPVEERQDEAFRSRGITLTSAQRSKLRILEVDASSSNLGLLTSDYEWLVQNGTHIIHNAWPMSGTRPFKAFEPQLQALRNLLDLARDMSRRKEAPRITFQLVSSIGVVGHFKAPRVPEERVSLESVLHIGYCEAKWACERILDQTLHKHPDVFDAMVVRPGQIAGSSKSGFWNPIEHFAFLVKSAQSLRAWPDFDGVVQWVPVDNVAHTMVDLLYLGDVDRPERHPVYHIDNPVGQPWKIMSQALAGALDIPPRRIIPFSRWVKLVRNSPLPAETWNPAARLIDFLDSNFERMSCGGLILDTVKAQKHSSTLSAQGPVTTEIAVKYIEYWKGSGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPD7</accession>
    <name>S0EPD7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437016.1">
        <property type="nucleotide sequence ID" value="XM_023569860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPD7"/>
    <dbReference type="STRING" id="1279085.S0EPD7"/>
    <dbReference type="GeneID" id="35404476"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11012"/>
    <dbReference type="HOGENOM" id="CLU_015355_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF57">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT74938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="607" mass="65302" checksum="CF66FD939A8CD9FA" modified="2013-09-18" version="1">MVLEAYTYVFAIGSCFALLEAYNNGANDVANAWATSVSSRSVTYRGAMVLCCIFELLGALAVGARTASTIKNGIIPMESFRDNAGVQLLAFACASAGASIWVMWCTKHNAHVSSTYSLISSLAGVGIATVGASKVEWGWNGGQGLGAIFAGLGMAPAIAGCFAAIIFSLVKFVVHVRKNPVPWAVWTSPFFFLIAGTICTLSIVYKGSPRLGLAEKPAWYIASVTLGVGFGLFFLSAIFFVPFVHAVVIKKDYTLRWWDAVQGPLLFKRPAPPDAENARVPNYAVIQHGPEEDDVSVSQESEDPSPKKISDDEITPAAAPSSEVNEKQHLNLSESTQEDYQKMLKKAEEKHHANLRKGKGPLGWAMRTLHANPIGAGSIHETHNLIALVKRIPAQIVVALLYGAHYDIHTAQMGIEATPEGRRMARVYEHAPKYPNEVEYLYSFVQVITACTASFAHGANDVGNAVGVWAGMYAAWHSGKPAEKKAEVPLWQIGIVAATICIGFITYGYNIMKVMGNKITYHSPSRGSSMEMGAAITVLVFSQYKLPVSTSMCITGATVGVGLCNGSLKAVNWKRVFLLVFSWIMTIPIAGLIGGCLMGLALNAPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHS2</accession>
    <name>S0DHS2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423651.1">
        <property type="nucleotide sequence ID" value="XM_023572640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHS2"/>
    <dbReference type="STRING" id="1279085.S0DHS2"/>
    <dbReference type="GeneID" id="35395429"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01946"/>
    <dbReference type="HOGENOM" id="CLU_123440_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="180" mass="20570" checksum="D48A4B89AFB33C64" modified="2013-09-18" version="1">MTVEYECGFSMYPPLPPTPSNQSLYALFLARLRTTFSSRTHPSTSKPLLITDADTAFYYFTLPKYPKIPANPEHCNFFLSFCLSFGNGGLPREVAVAHVLEVFVISKEYFGERVRYWNGMHRMRCNKQWGYYTLADVKEAEAEVRKLCRSMDSKVTVLETVVETLDENNVVEVGPLFLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIB9</accession>
    <name>S0DIB9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423922.1">
        <property type="nucleotide sequence ID" value="XM_023576162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIB9"/>
    <dbReference type="GeneID" id="35395152"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01667"/>
    <dbReference type="HOGENOM" id="CLU_2133708_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="113" mass="11773" checksum="79AC15785AD07B2B" modified="2013-09-18" version="1">MINTSRSATTTAANTTAVGILETAALVCSVDLTLVTSLTAVPLLQAQIQTILNASANVIVNVLDRTVHASAILARTDIPHLSVVRTIAKHMTATMVARGVLSAKRIRVSSQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIJ5</accession>
    <name>S0DIJ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424360.1">
        <property type="nucleotide sequence ID" value="XM_023581573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIJ5"/>
    <dbReference type="GeneID" id="35394668"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01183"/>
    <dbReference type="HOGENOM" id="CLU_035511_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="611" mass="68511" checksum="C359075DE8BE7610" modified="2013-09-18" version="1">MSGPTQSKMLVVPPALNLRRASSYNAQDRGPVSSTSSRFNFNHLFFSPPASPALPALVPRPPKRTSSQILVARPSRVFRRLFLLGILLSITYLVALAFQNPDAIPAAVWPYFGQEEFEMVGQDAFPDFPTPILINDIKGRSKWTVFIPPNGDFPLTMDQYAEMGSQCREVSSRARDIHHKAPITEKAIISYDAKDEYYIDVYDAERSGLLAPYKGIRAKNKGKFVGVDKKHLKHKPVCESTMTFVLESSDAGLGNTLMMLWTFYGLAKQLDREFFIVDKRWAYGPWTEIFEAPPVPDCRPPPRHHMVPCPFQARHLVVSSATAKEVFPALLAQNHRVAGTEDGLRDLFELARIGYEDLFILSDEDQAYVDERVTAIQAKANAEGSLMTHIPIIGLHVRHGDQHPLEFQYRDTYIPADVYLKQVTRYVDEYYNMTGMEDNTQRRHITLLASDDPTVHEEPEFSHTILSQDRIRLASKGAIARASGNHHSLNNFVENTFGWEGGFFAPLFWNLGVESKNNAAEAPAGVNVDGVNEEARHMAPPSEETLRLRSLVGRAYMMDLAVLSESSDKIVCTVSASGCRLLAVMMGWEDSMENGGWHNVDGTYGWAGIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ99</accession>
    <name>S0DJ99_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 16">Sortilin VPS10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Vacuolar carboxypeptidase Sorting receptor VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">FFUJ_01139</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424402.1">
        <property type="nucleotide sequence ID" value="XM_023582061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DJ99"/>
    <dbReference type="GeneID" id="35394624"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01139"/>
    <dbReference type="HOGENOM" id="CLU_000700_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="23" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484247" description="Vacuolar protein sorting/targeting protein 10" evidence="21">
        <location>
            <begin position="27"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1419"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="22">
        <location>
            <begin position="53"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="22">
        <location>
            <begin position="750"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="662"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1473"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1480"/>
            <end position="1497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCT62321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1497" mass="166845" checksum="0295FA1ACD9FA23D" modified="2013-09-18" version="1">MMRSSAWAALSWRALIFSLLWTAVAAKQDKPTVDASVAKHPPLNLNYFEDSDVVVFQDIEERNIWRSEDAGKTWAQVPDIPDRSATFLYLHPFDSTSAFVLTKDRKHYKTEDRGKSWSEFNSGTMPSAFQPDTLVFHAGDPKRIIFNGMNCDGIFCDEETTYTIDGFKTVQQLRPSTSGCWWAKTNREFTTGDAELDKTRILCIVTDPLSLFKTSQKLCVSDNFFAKGSGGKFDEFEPSLDGQRDVTGVVSIAAVKSFILLASSSAGSDEMTLFVTSDAQFWHRAMFPTDDSHDHSHKINQEAYTVLESTNYSIQVDVMTSHPSTPMGVIFTSNSNGTYFTENIPYTNRNVKGHVDFEKISGIQGIFLVNTVENGKDVDAKSAKKVVVTQITFDDGRTFEPVKAGQDRIHLHSMTDIDNIGRIFSSPAPGLVMGNGNTGAALGEFESSNLYVSDNAGVSWKKALEGPHKYEFGDTGGILVAARDSLKEDVDKISFSLDYGENWESAPLPDGLKVRPVILTTTQDSTSLKFLLIGEKDRAFHMIAINFEGMEKRTCESKDMESWYARVDDKGAPTCIMGHKQTYNRRKKSADCFLKADFRDPEPVIENCECTDADFECDYNFQRDPDDNKVCKKVGPVPIPEGSCKGKDETFKGSSGWRLIPGNTCTRKSGAQKDDPVERKCSDGGSPGGGSTPGTPASGEISLKINEFTDIKGQDMQKFYLMGLESESPTSEVVIARPIGDKLPGGKVEVENKLWITADHGKTWKRILEKENILGLIPHTYFREVVFFHTDSEKVIYTIDRGHSFHSFKTPFSDPGAAMSFHPDKKDWIIWIGKRCGDVAGSKDCYPEASISTDRGDNWKTLQRYATKCEFTGNSAFKFRAQKQIVCLVHKDENTDNHKTIVTIEDFSEDDRIFHNGTVAAFATMNEFILATDEVIEDGKESAGLQAIASMDGKHFEAAQFPRNFHDSHSSLYTVLDSSNHAVNLFVATDLSEGRRRGSIIKSNSNGTTYVLSAPNVNSDELGYVDFEKVAGLEGVTLINSVSNPDDKNGKKVIQTKISHNDGAEWGFLPPPSKGADGKSYSCSSSGDRQCALHLHHYTERENKGRTFSASTAVGLIFGYGNVGPSLGDVKEADTFMSADGGINWKSVKKGVWTWQYGDQGSIIVLAQRATLANKIKSNIVSYSTDEGNTWTDYKFTDKEVTIQDLTSVHSGTSRNFLVWYQTDDKKLFAANLDFTGLTNQPCKYSDDSSSDYDLWSPKHPLQNDDCLFGHKAKYLRKKTDRKCYNQASMSRLREYENCECTRRDFECAYNFELDNHGQCTLVPDHDALSGEEWCKQHPNETSYFDPTGYRRIPLTTCEGGQELDKTSTEHACAGHEEDFARKPAFGWYAWRNWSGKFGQIRLGDNSATFDSEQPWIKYPVIAISALAAVVAALPLVLTSIWRSATGVYERVSNRSRGGNWSRRYTTRDSFARGRGDYSMVDDDEGELLGEESDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJF8</accession>
    <name>S0DJF8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424745.1">
        <property type="nucleotide sequence ID" value="XM_023571452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJF8"/>
    <dbReference type="GeneID" id="35394247"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00762"/>
    <dbReference type="HOGENOM" id="CLU_034574_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37119" checksum="AA5D25C6DD3D4A9A" modified="2013-09-18" version="1">MGVGRFFCVLLPFVLTVGSIIFLLVGALAGVADKSLYIFRIDVKNLSISPADVGNIIDNLDLKNLKLDTRDVPVIEERADKIKDNITAELLGLDKYYDINLWGFCKTDSDGKRKCEKPEFDWANKKLNTSYLIGADKNVQIELPDEIQDALKAFKTVTKWTQVVYIAAFIALAAEIILGIFSNCSRIFSCLTWIVAGIASTLVIAAVVLSGVFAGTVVGAVEGTAKFYGVKGDINGRFFACVSIAAAFAIAAGLFWMFTICCCKPESRSRDKKNRRSDGEKLLGGATNKHGSYAPLGDDHEMQTGYYNHNQSQSQYGAPRYPSGTARSDLAYEPYSHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJM4</accession>
    <name>S0DJM4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424840.1">
        <property type="nucleotide sequence ID" value="XM_023572618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJM4"/>
    <dbReference type="GeneID" id="35394142"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00657"/>
    <dbReference type="HOGENOM" id="CLU_2483544_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="87" mass="9700" checksum="3690EAAC9D001D12" modified="2013-09-18" version="1">MAARVIQPHFTQKRSQTALVERMRGSDSIAASRIAGTRRRRKIHCEPLGDMHQLQRPGLQSSDGKDLSHGAVSESGCRECNQRERGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJN0</accession>
    <name>S0DJN0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1776-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424850.1">
        <property type="nucleotide sequence ID" value="XM_023572752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJN0"/>
    <dbReference type="STRING" id="1279085.S0DJN0"/>
    <dbReference type="GeneID" id="35394130"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00645"/>
    <dbReference type="HOGENOM" id="CLU_022136_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="54061" checksum="38FA991A2965A228" modified="2013-09-18" version="1">MSVDPQQLLDTLSSQVRQYADVASEFIDKNVDRAAVVVRETLSTSEWVPESVRPKPAVKEVVAVVSLGRFERLQNWIAEHKILTGMIVLTCGTVVYKGYYESRSMRKTRRARRARNGGRTDVVVIAGSPSLPLTRSLSLDMERRGFIVFIVCNAAEDESMVQAMKRPDVRPLSIDTTDPPNAGSAIEHFAHFLQSPQAPGPGMKPNQLTLKSVILIPSLHYQTSPIATIPPSSFADLFNTHLLQPILTIQAFLPLLTSRLNPIGEKWIPPKVLVFTPSIISSINPPFHAPEATVCSALSAFTEVLTAELRPLDIPVTHMQLGTFDFSSFVPTRGGPNQGLVTAGNPESPLVWPEGARHVYARNFVAQTSSAISGGRIRGLKGSSLRRLHNSVFDVIDGSITADTVRVGLGASVYGFVGRWAPRGLVSWMMGIRRVDELSTWKTSSYEGSESSDEDDESEKGEGESSEFVAVPSDANVWHADNEGAMWTPQASETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJY5</accession>
    <name>S0DJY5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Probable peroxisome assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_00513</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424970.1">
        <property type="nucleotide sequence ID" value="XM_023573209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJY5"/>
    <dbReference type="STRING" id="1279085.S0DJY5"/>
    <dbReference type="GeneID" id="35393998"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00513"/>
    <dbReference type="HOGENOM" id="CLU_024591_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="15">
        <location>
            <begin position="79"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT62889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="438" mass="49362" checksum="306E4DCA99C8B3A2" modified="2013-09-18" version="1">MTDSSFVQAQRRVAARRQTREAEATARIAAHRQSSRPRANLERLPYPLNRIGSAWDAVSTREGTRPAFRVGQVDAELLDVELLDILKDQVCEGLKYFGGGHLHDDWSAEIMLALRAVLFKLTVWDHDATYGAALQNLKYTDARNDGLILKAPSKVQKSLYGLVTVFGNYAWTRWEDWLLDHDDGYDEPSPRVKRLSKLTSTLSTVHSAAACVSFLVFLLHGRYRTLLDRILRMRLAPPTSQVSREVSFEYLNRQLVWHAFTEFLLFVLPLIGIQRWRRWLTRTWRKTKDIIRTGPQEEGKANGEYAFLPERTCAICYQDQNTATSENEVMAAAASSGVIGSAQTDITNPYETIPCGCVYCFVCLATRLEREEGEGWTCLRCGEHVNECKPWSGDLVEPSAKHASAKTVAFSDDITGGVLVEEQEDDESFVESLSTASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK34</accession>
    <name>S0DK34_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424792.1">
        <property type="nucleotide sequence ID" value="XM_023572051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK34"/>
    <dbReference type="STRING" id="1279085.S0DK34"/>
    <dbReference type="GeneID" id="35394193"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00708"/>
    <dbReference type="HOGENOM" id="CLU_064118_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="368" mass="41016" checksum="F7591FECD1CAFD18" modified="2013-09-18" version="1">MTGKPVYKPDEIRFALSLMEKDFYNDAISNAFRERFNRALTDNQIRYLRNKYGKDPDYGAPLCNKQSKKRKERRSDSGAGSSASPGSEGSPAEAKRARQGSFKASAGPSQQPPYQFESLPTQSSVKFEDTKSPSPSSVPLFHAAPMAQMGNLRSPPPNSYNLFSGAPAATGLRSMPLANSWQTQARANFNANFSPINTHFSQHQIKSPEQRNPEGYNAALYQTPHQSPNAQLSYDSYLRQQPIASSHALVSSPQQTVVMEMPLSNFSQLSDFVYPQQVSHTEEYTQEQEQEPEMPRRDDIAPMYCEEYFEPTQRAAEQGETQPTQDQDEETPEKKISQDRKQSAASGASRDSNEHQAAKAGSSHDSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKA5</accession>
    <name>S0DKA5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_00604</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424887.1">
        <property type="nucleotide sequence ID" value="XM_023573108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKA5"/>
    <dbReference type="STRING" id="1279085.S0DKA5"/>
    <dbReference type="GeneID" id="35394089"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00604"/>
    <dbReference type="HOGENOM" id="CLU_118180_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT62806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="91" mass="10086" checksum="EE8BD4DD78BB5B18" modified="2013-09-18" version="1">MDQTQAGGLLDPPELTPLEQEVLDEYERLADNMNKLATVLEHLASNPSTEILDGLRELERKTSLAFTLLKASVYSIVLQQEIDWGDGSTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKJ6</accession>
    <name>S0DKJ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425185.1">
        <property type="nucleotide sequence ID" value="XM_023573469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKJ6"/>
    <dbReference type="GeneID" id="35393765"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00280"/>
    <dbReference type="HOGENOM" id="CLU_2223120_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="112" mass="12077" checksum="589447876AFCFE86" modified="2013-09-18" version="1">MATIKFTNNYIRVNCDPTVKSINLFLDDKSEELPNDGKFSSKKYSGESKKAIVTYKVPPPAPTTYSVGQGVFFPDGAQVTITGGADGTQLVQAEDKNGNKGTWILVGADEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKS6</accession>
    <name>S0DKS6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable F-box protein involved in pathogenicity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424053.1">
        <property type="nucleotide sequence ID" value="XM_023577772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKS6"/>
    <dbReference type="STRING" id="1279085.S0DKS6"/>
    <dbReference type="GeneID" id="35395007"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01522"/>
    <dbReference type="HOGENOM" id="CLU_510932_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="119"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="525" mass="60309" checksum="EF556B1D1338D9DE" modified="2013-09-18" version="1">MAHHQARTVAMDPPHITEFASERYFEKLSQLNAHQHQHQHPPTRDNLDASTSPSRFILPLRETKTADVEPLRPLDQKRDKSRFFGLRSKVSILHSKSNVSSGHAPRVSVETPQKSASFDQLFLGLPNELQIQIISALPLTDVLNLRLASRSWHTLVTFNENTIARYHLEHHIPVYASRLYPITDPSEINFQHLCGIWHRLHVAAKLAFLMCEWITKDIFLRQTEAQRLAFAPQNERMRRRLIPLLFTIFHFFETYRKLYLKRMAENGGKGLRREPYTLNPIEAEIMSMYDDQTLLRVHEVFPLVISSFCRRLRPPTYVGRVERSLRGYIREKPSDDMHVAILCIGGLRQVERLWEIKGYNSRRGAVDTWFNALTKEAPPTEQSTSKPKRGLFGRKKSTSEARSSATGLNKVRSSGSIDGNMDWETNLVFNTSLSAGAPMSPLTLQQAQALLSDLPVLQQIWLTTAEALILQRRVVERPQDIKRNQQVMLDLISEDGLVEEDEWWYGRSIPDSVRPPVGVTDDDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLB3</accession>
    <name>S0DLB3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_01345</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424213.1">
        <property type="nucleotide sequence ID" value="XM_023579761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLB3"/>
    <dbReference type="STRING" id="1279085.S0DLB3"/>
    <dbReference type="GeneID" id="35394830"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01345"/>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905334">
        <property type="term" value="F:Swi5-Sfr1 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030491">
        <property type="term" value="P:heteroduplex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007533">
        <property type="term" value="P:mating type switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000708">
        <property type="term" value="P:meiotic strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036298">
        <property type="term" value="P:recombinational interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120290">
        <property type="term" value="P:stalled replication fork localization to nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="99"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT62132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="348" mass="37564" checksum="689461F667375B52" modified="2013-09-18" version="1">MSEEYDEAQMGEEGGMPGPGAPTPLSALEGISGLTKRDIQLVIDGGYNTVESVAYTPRRVLEQIKGISEQKATKILGEASKLVPMGFTTATEMHQRRSELISITTGSKNLDTLLAGGIETGSVTELFGEFRTGKSQICHTLAVTCQLPFDMGGGEGKCMYIDTEGTFRPVRLLGVANRFGLSGEEVLDNVAYARAYNSDHQLQLLNQAAAMMCETRFSLLIVDSATSLYRTDFCGRGELSNRQTHLAKFMRTLQRLADEFGIAVVITNQVVAQVDGGPSAMFNPDPKKPIGGNIIAHASTTRISLKKGRAETRIAKIYDSPCLPESDTLFAIGEEGIGDPAPKDMEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLG7</accession>
    <name>S0DLG7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425352.1">
        <property type="nucleotide sequence ID" value="XM_023573675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLG7"/>
    <dbReference type="STRING" id="1279085.S0DLG7"/>
    <dbReference type="GeneID" id="35393583"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00098"/>
    <dbReference type="HOGENOM" id="CLU_017444_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494954" description="Protein kinase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="571" mass="62943" checksum="D1B4FE9A8EB6EA2D" modified="2013-09-18" version="1">MDPGTALAVVSLSFDLFASCVRGFTLISDARNIGKDAAIERTKLVLQEHRLIEWARAIGLNPPRDDASLEIHKHPAALILFQLEQLLSSTDALKKRYKLELVSPPNDSDNLVPSESAIFSDNPASSILSTIVSPEIRQGILKRASTLNTANRLPRRLYWAAVDKKKYAELVQDVTGLVDGLWSLLDIPHRIQTSRAVNQTLQLAIQASEDIKGLQYLQKSLHDSFIDAGVKNSLAASAGLKAQHILLTSHSGDAQQQVHSDDETNRVLPAELPSVLDPSQLSGIHMMTPTIGSALYQGDPVLIEEKRVQPRMKGKLKPRVEALVRLLSQPPTPSFQTFPCLGYTEEQGGFRLVFSFPPGTEKPPSLLSVLSKSSGPLPDVGMRLRLAAQVCQTLLSFHTAGWLHKDMRSENILLVSPTSNSSIDRLGRPYLCGFSFARQGSPTEISEQPSEDLSRDIYRHPKALGEPSDSFERYMDAYSLGCVLIEIAEWAPLRKIVKKRVDISHSSGVTLADVASLSQWMYDRYITEGFAAFRLGVAFMRMLAMCIPAGDKKPDLADFYSALESMAAYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLJ6</accession>
    <name>S0DLJ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_01075</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425565.1">
        <property type="nucleotide sequence ID" value="XM_023567975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLJ6"/>
    <dbReference type="STRING" id="1279085.S0DLJ6"/>
    <dbReference type="GeneID" id="35394560"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01075"/>
    <dbReference type="HOGENOM" id="CLU_000688_6_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="215"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT63484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="440" mass="49107" checksum="623C7D77E11458D0" modified="2013-09-18" version="1">MPSATGSNWEKYQKNFADDEVEEKKITPLTDEDIQVLKTYGAAPYGTSIKKLEKQIKEKQQSVDEKIGVKESDTGLAPPHLWDVAADRQRMSEEQPFQVARCTKIIADEKGDEAKSKYVINVKQIAKFVVQLGERVSPTDIEEGMRVGVDRNKYQIMLPLPPKIDASVTMMTVEEKPDVTYGDVGGCKEQVEKLREVVEMPLLSPERFVNLGIDPPKGALLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAIGGARFDDGAGGDNEVQRTMLELITQLDGFDARGNIKVMFATNRPSTLDPALMRPGRIDRKIEFSLPDLEGRANILRIHAKSMSVERDIRWELISRLCPNATGAELRSVCTEAGMYAIRARRKVASEKDFLSAVDKVIKGNLKFNSTATYMQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLR6</accession>
    <name>S0DLR6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-binding loop region of homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425466.1">
        <property type="nucleotide sequence ID" value="XM_023573762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLR6"/>
    <dbReference type="GeneID" id="35395367"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01884"/>
    <dbReference type="HOGENOM" id="CLU_778554_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.75.10">
        <property type="entry name" value="Homing Intron 3 (I-ppo) Encoded Endonuclease, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008704">
        <property type="entry name" value="Endonuclease_Zinc-binding_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044930">
        <property type="entry name" value="Homing_endonuclease_His-Me"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05551">
        <property type="entry name" value="zf-His_Me_endon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-binding loop region of homing endonuclease" evidence="1">
        <location>
            <begin position="202"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="356" mass="40108" checksum="6637BFB236B547DC" modified="2013-09-18" version="1">MANKLTKGAWFNPIVIDDEPEAVKQEIPFAPGPVPTPGPVLTPGPVPTPGPVLTPGPVTTPGPVTTPGPVTAYPPIRFGTMRTRNQLCRLLQEAYNTSPEEFHQKIDRAYAQFLYKFSTTQEAFLTRMQPIFNNGNCFSGFTQVFPSANLTQLMQIMLHADKRQTWALFSMYEINFSIFRDTAPRAQRKAFYILVNHDRNDLQRLLTCEVEISHLCNWRRCINPDHVTLESHTTNISRKSCFTQAQGHFSAGLPVKVSCDIHNPPCLLQQAALPTTTKVINEWEAMGRPLPEVLPEQMDSLNAELLTIPIGQYIWVNNRRVVIREYTIPVVNDEYQGTQAPGMIYSSILVKELMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM74</accession>
    <name>S0DM74_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_01876</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423729.1">
        <property type="nucleotide sequence ID" value="XM_023573851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM74"/>
    <dbReference type="STRING" id="1279085.S0DM74"/>
    <dbReference type="GeneID" id="35395359"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01876"/>
    <dbReference type="HOGENOM" id="CLU_081350_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT61648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="255" mass="30280" checksum="6F47372888D7A8B8" modified="2013-09-18" version="1">MGGRQIRPARVLQTVTEELNHNVLGDKSIPTPPWYNIMQSVPPAETLVRNVTPRLRSPNLQVRKPKNLYRPQGIWYREDRLRSTFYRDHPWELARPRVILESDGKDYQYCDWSKGLRQPNIPLSGEWQVSLDRYVVQRQLWLMEKERLSEKKAYDITRREFYRLRQEEEIEKRVALEEAKHVGAYFGKSRIDVSHQLEDREFENWKIWAGKETERQEASRNSEIEDFGLEEVEEDIADDAEPEEKAEAVEGKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMQ1</accession>
    <name>S0DMQ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to nif-specific regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_00788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424723.1">
        <property type="nucleotide sequence ID" value="XM_023571163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMQ1"/>
    <dbReference type="STRING" id="1279085.S0DMQ1"/>
    <dbReference type="GeneID" id="35394273"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00788"/>
    <dbReference type="HOGENOM" id="CLU_031130_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="542" mass="60358" checksum="FC7AE441522F089F" modified="2013-09-18" version="1">MAANEAAALANMANRTDRRSPAPASQSKRDRKRQALIERLSSMTDKFHRERDMTYRDQLQKIQFDINLVQRFDPYDPKVLEVISELQKEHTNTQGPPVNAEDARSLLDMAGIRFSDFVDEVEDLVEIRDFQLAQSKNEYDRRREEYRNTYDYKVETAKREHRALTSTLRDRLVNTLTHKKNRLNREKEVLEINDSNALLLNPNQFSLTNPASPGGPHGKRATRLRKDADDLQMYSDNKKRKRNAGDDDGSPAPTRRALDNHNTTPLWQSEKARAAAKQNGPIYSIDKLFTDKELSLNYNTAALAAHQYILRNRVSGGGSPEDSDSGNGEANGDQDADSQPSAPAMERSVSHATRSTRGGNLLDDKILGLEGITNFEVHNLDILHAHEPPKMPPPVPQQYLKPYPRTADQNFPVPLSNDDITSDLTIMGFFKQYDAAHKPGAHLDRPTGMRRVLAAVSIPYQHSRYVAFTSAPREDPEYVRDSLGLPALSSLRDQPSPAHAGAATSVAALSSAAVPMSRQSSAGGVAMSRQGSSSTRGKGRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN30</accession>
    <name>S0DN30_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_01542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424039.1">
        <property type="nucleotide sequence ID" value="XM_023577550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN30"/>
    <dbReference type="STRING" id="1279085.S0DN30"/>
    <dbReference type="GeneID" id="35395027"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01542"/>
    <dbReference type="HOGENOM" id="CLU_064992_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="162"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT61958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="257" mass="28569" checksum="A9E85887AE266E44" modified="2013-09-18" version="1">MPAPTALKNAEDAPPAVDVPLPVEENDEEFLLDAPDALPTDAHVLVPVEESNENGMAIDEEGRPRFAPARDIDPVTRVETRKIPIPPHRMTPLKQSWTSIYPPLVEHLKLQCRMNIKRKTVELRSSKHTTDTGALQKGEDFVKAFTLGFDVDDAIALLRLDDLYIQTFEIKDVRTMHGDSQARAIGRIAGKDGKTKFAIENASRTRIVLADSKIHILGGFKNIHLARESVVSLILGKPPGKVYGNLRTVAARMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN76</accession>
    <name>S0DN76_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_04938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425972.1">
        <property type="nucleotide sequence ID" value="XM_023571716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN76"/>
    <dbReference type="STRING" id="1279085.S0DN76"/>
    <dbReference type="GeneID" id="35398419"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04938"/>
    <dbReference type="HOGENOM" id="CLU_045435_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="342" mass="39080" checksum="0338A72CB08CE9B7" modified="2013-09-18" version="1">MIRQKWLPHTRAIFAAQKRCLSSPSSGFPRFVKNDESWGDLKEKLNSSLARASPGGILKPKPVTRTPLKEAMAEDLGSRQMLVIEGLPTSLVAADFHRLAPGTLAGWENAITHVHQERDPWTMEPLGTYSITFPSSGAAEIYRDRVERILRLAQAKMRDGTGLWATNVNPVLINKKTKPEVEVERFTLLPGSYPSAPKIKTKRVRKMAWQQVMDRIVKKSSHKRNPSHVLLELPQASFSASELKAIIKQDGIESGHDWQMDVFSLRETMDFEKGFPTNTRRVPLYRSSPEFRHKLDSRFVLTCANPEVAWRFIRNWNQRILEYDGGDEVFQRNRVKASYIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN89</accession>
    <name>S0DN89_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424948.1">
        <property type="nucleotide sequence ID" value="XM_023573183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN89"/>
    <dbReference type="STRING" id="1279085.S0DN89"/>
    <dbReference type="GeneID" id="35394021"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00536"/>
    <dbReference type="HOGENOM" id="CLU_016357_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056669">
        <property type="entry name" value="DUF7767"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057940">
        <property type="entry name" value="Tri-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24962">
        <property type="entry name" value="DUF7767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24465">
        <property type="entry name" value="Tri-helical"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Tri-helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Tri-helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7767" evidence="4">
        <location>
            <begin position="581"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="677" mass="77488" checksum="760A5F2F16C570BF" modified="2013-09-18" version="1">MVYQWEPHKDVCYQLYINERRSLEDIMVHMKNVYQFTPSKRAFQVQFSRWKFPTKQRLKHKDDRLVNRVHELWKRNVPQSEMLRILTDEDGFDINSRELMRVRARNRWLLRVRNGDRARSGGDAEPDDENLEDDTSLDDRDVTIPLPDQEPRDLDQPTIYAPENSTQEDSISVPTTPKPRKISKRQSRRNRQHLTESEHIVRFPSEMTLNDSKQALGLDATTYAEARECFARICQEESIVKKTQAGPGRWDYVKNRLIHERPHLQQALWLSKEDLERKQLALDVICTDVTKRLRNQDTRMTLVDAKNELGLNPEESHEIRAALHEVLCDAKFTCKTDGTPEQWEELKKRWLEKSERMRAIPLHGNDESSRRKVKAVEIVARDVIKRRRDEKRSKTTKSGKAPKQKESPKRKSQNDKPRDTVQDPQLTEAQPSIYQQQAQRAIDKPHAFGMSERGAPGSSSPAHPMIDQPMDDNGYEPVHEPVVSRIAYTTPGQPPAPQRPGQVQLPALGMPTSQAVLPQPHRMLGSSTTNTVPMDAQYSSSMYLGNQPQANYMQQQYVQHPFSASASNTMFSPVPSVPAVPSSFAVFMRLHPTSTYPANTSLWISTMSSQSIQELRQVAVAKFPGAMCVRIEGIIKDPKGNELPLQIQGDDELAAYFDHMQSGTPTFTVQLVQHGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNB7</accession>
    <name>S0DNB7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to UV-damaged DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_04892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426017.1">
        <property type="nucleotide sequence ID" value="XM_023571768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNB7"/>
    <dbReference type="STRING" id="1279085.S0DNB7"/>
    <dbReference type="GeneID" id="35398373"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04892"/>
    <dbReference type="HOGENOM" id="CLU_002893_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="4">
        <location>
            <begin position="12"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="5">
        <location>
            <begin position="441"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="804"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT63936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1175" mass="129950" checksum="DB0A37C022B415AE" modified="2013-09-18" version="1">MAYVAPIHRATSIRHALRANVLSPDIDDLVVAKANRLEIWRLTEEGLVCLQTKLIHGSIAMLQCLRPKGSETDLLFIGTDRLHYFNLAWNPLTKQLETIERVIEDLAEPYMRHSSSQNKCLVDPTGRFLAMHLWEGVLNVFKLPIRKGSTNKLERLDQVRLTELFMKASTFIHSRTGHPTIAFLYKTQLEQEEARLVIYRLTHDDKGNTVSKFDPHKDRELDVVIPDPYASMLIPVPLDEEKRYHVRNTEGAKAHLGGLLVVGETLLTYFDGLTHRSVSSVLQDPRIFVSWAEYDGTHYLLADDYGRLDLLTIDTNLETTGVVVTGMTLEPLKIGRSPAITSRASNLVYLGDNTLFVASHHGDSQLYQIDVESATVTPIQSFSNNAPILDFSIMDMGNRDGDTQAGNTFSSGQSRIVAGCGAYRDGSLRSIRSGVGLEDRGVLDELEGTRGLFTLRSYASDLVDTLVVSAITETRVLSFDREGGIEEMYSFQGMSLDTETLWASNLPNGQLLQITPRSVVLLDPESGTVTSKWDVPSGKSITRASANSKWALLSVDGTSLVSLNLLQNLAVNVQQSQNNSGSQADQISCIHAARDPPDLGVVGWWSSGQISLIDMASLKPLHGESMRQTEDSATVPRDIALVQLHPPEISGPTLLVAMEDGNVVTFNVSTKGFAVSGRKSVTLGSNPARLHILPQQDGTSNVFVTTEHASLIYGAEGRIIFSATTADDATFVAPFDSHAFPDSVFLSTDQHIRICHVDKERLTHVKALPVNETVRRVAYSPGLKAFGLGSIKKELVGNEEVVSSSFRLVDEIIFKELGSPFPLNASSSLEIVECVIRAELPDVGGNHVERFVVGTSFISDGVEDPNGTGGRILVLGVDSNRQVYQIVSHNLKGPCRCLGIVEDNIIAGLSKTVVAYSFLQETSSSGSLQKLAVYRPAALPLDLDVSGNMIGVVDLMQSLSLVEFIPAQDGNKAKLEERARHFEPLWATSVCHIEGERWLEADSKGNLVVLQRNVDAPTEQDRMRLEITSEMNIGEQINRIRKLNVPMAENGIVHPRAFLASAEGSLYLYGDIAPQYQDLLMTLQSKMEEYIHVPGSVEFKLWRSFRNENRESEGPFRFIDGEMVERFLDMDEGKQELVCEGLGPSIEDMRNLIEDWLLDVQDEWVKDDWPEAMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNE9</accession>
    <name>S0DNE9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to C6 zink-finger protein PRO1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425013.1">
        <property type="nucleotide sequence ID" value="XM_023573266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNE9"/>
    <dbReference type="STRING" id="1279085.S0DNE9"/>
    <dbReference type="GeneID" id="35393948"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00463"/>
    <dbReference type="HOGENOM" id="CLU_019313_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="611" mass="68844" checksum="413ACC3CEDD078DF" modified="2013-09-18" version="1">MFRHLMSSKVRSNAGCWTCRLRRKKCDEKRPVCDSCGALEISCFFDEEKPEWMDGGPKQKAMAEKIKAQVKKQASQRRDRKYMEMLEAGTRNVTLQNEDQSQRQPHDAAMSAASDTDPASGHEFGSTPASSNTSGASPPDMPWHSHFVVPAEDSSSSTGASTEIHFIMIYLDYVFPYLFPFYRPPILAGGRGWVLDVLQSNKSVWHTAVSLTSYFFSIVMANGAVEHQECTNRMVHQLQSQLEMGLRELQREMTAVNHKVSCAGVRDRLLVLQAILQMLIFEVSTSNKDHWKMHLDAAITMFQQILPQSEKWGETLEALYSYRWPPPEMGIRRPFSTNQAALRFFTANVLYIDVISSITLEQAPRLQKYQDNIMPSCKTYTTPQEVRISGSLFMEDYVGLNNWVVQIIGDIAALDAWKKEQKKKNSLSINELVQRGKIMEDALKGGLSVIEAQIQASGPFFDPVISVVANPTQNYGYGVDTKQAPGLAVNNMIWLQAALTYLHVVISGWQPSCPEIQASVSRMTELLTTLPPNVCLRTLVWPFCIAGCLSPPEDEDRYRAMVERLGPVSVFGTIREALEVMEKVWSRRDQIDESWDVAKCLQILGHGVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNR1</accession>
    <name>S0DNR1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_04573</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426310.1">
        <property type="nucleotide sequence ID" value="XM_023572125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNR1"/>
    <dbReference type="STRING" id="1279085.S0DNR1"/>
    <dbReference type="GeneID" id="35398054"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04573"/>
    <dbReference type="HOGENOM" id="CLU_013294_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="426"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="570"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT64229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="661" mass="73855" checksum="F0F466684FEBE70D" modified="2013-09-18" version="1">MSTFNGIVSEFPDIRIDFFRRNAGAQPPLACFLSHVHSDHLAGIESLRSPFVYCSAATKEILLRLERYPCRINYAKGVLESRQQTFKHLRKVLKPLPMETPTSIELCPGREIQVTLFDANHCPGAVMFLVEGDKKAVLYTGDVRSEPWFVSALSRNPNLIEYTSGIKTLDKIYLDTSFTENVPFQTKAQGIAELLRKVSQYPSDTIFHLQAWTYGYEDVWLALSKALKSKVHVDDYKLRIYGSLKSKTSDSRFDTDIHLTPESPALTGHMCGNTPHPGCLTSDENVRLHSCEKGSLCEVAQRPTTISIQPIVAHLPTGEDLTEVGVGGGGVDLQREAELEFLDQASLATLFNTFLSSSISSTDMSDILEGTLEKIASTGRNIPLDWDINTLNAHSAEEVIMMLVDKVRKNPKNQKQRDECSLPRTIYFPYSRHSSLPELRHFVEAFRPLDVWPCTVNNAEWLKNGITIGGMFGPSCSGELFEHDLVMQDFAATHISDNGHQQHCSQTTIGSDSVPSSPVRSIRHGRIVSEVECPEENLEAPSENSTQQSLVIHTIEQSEDVQQENHICPESLTTNSSDSPAPVSCHRKRTISDTSVSGNGSNRRQMRQITEEPLPLKLLDEASIGRQDAYWHMVDYMDEGTWGSLQLISTNNEYTVNEPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNW8</accession>
    <name>S0DNW8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_00312</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425158.1">
        <property type="nucleotide sequence ID" value="XM_023573433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNW8"/>
    <dbReference type="STRING" id="1279085.S0DNW8"/>
    <dbReference type="GeneID" id="35393797"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00312"/>
    <dbReference type="HOGENOM" id="CLU_018497_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="9">
        <location>
            <begin position="480"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT63077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="785" mass="88514" checksum="F038089438DDD3E3" modified="2013-09-18" version="1">MDPLSIISGCAGLITAIGSLSTSINTFVRSCREARSDLDRVSRELHSLQTVLELIEEDAKDDTKPFPLTIQHHVSGIVTNCGSVVLEVETCIKKYGDGRIKSKAAWAINGQGDMEKLRSSLEAHKSALELALDMISLSLTKDIKTDTTEIRNDTAAIKDDTALILQEIAQLQARLPDTAAAPNDYILQRFLEDMATYTETALDAEVDLCDRTSCRSLPIPDEHSQNSPVHVQDHLPIVAAEDPGTYEASLLAFRKKVQHLSSPRPHNYGRVQPSRPDKDVPQRPKGPGPVSSYSEVFYKKEVAPANDPRVSRSSALASSSRNEEMQHQITPSPVGVHQDDSHKQSSLSDFALLDDFDPLWRERYGEYLHDKAFSNDAVRENQEFVISLLKEVKAEMPYYPQQNYPPPPIAYVRAESDQGQPLPSIRAPQHTNPLNAASLGSPQQLMPYIVPTDGPIPREEDTVTSLPRAKYLSRQGEYHIQRFRGNVVFDLPVPDWILTCHSTPPDRNESTHRRISFITCPPEEFADQNYTLRPELFARPRQTQFILVIQVDPDDTDFILRWNLIHDSIAYAQQQSHGFWKRVIVHLHLAYGTTWGARSSDHPLDVLESIGAKQIMNTRIARIDSQPFGEPIGEDTSAISGHRVHAIMSEYTVQLCPVEDPPSTVATTEVPIQVVITTARVPEGLCAYWRDRYIPWTCAINKVLKAEHVIDMNVISHNSMLKNDFLWEILRMDRHIPFVKDKPFPGTDLEVLRFDSLIGEMRANENGGPWAIEKKPRKRWARWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP93</accession>
    <name>S0DP93_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425298.1">
        <property type="nucleotide sequence ID" value="XM_023573604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP93"/>
    <dbReference type="STRING" id="1279085.S0DP93"/>
    <dbReference type="GeneID" id="35393644"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00159"/>
    <dbReference type="HOGENOM" id="CLU_612553_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="451" mass="52843" checksum="767D666F967F67D6" modified="2013-09-18" version="1">MAVATAGPAYKLWFLSTGIVFLFFLLFAFYTDSIKSPLDYAHAKAAEFCSDSAAPQTTADADPKEGKFGNCKDPYRRPGYLYVPAETERYRETRWLPFTDKFLNSEDPETAEYPHTGGDLIFNDTDVPRTFFKGSDIPIEWMKLAVKENKRRQEAMAHITNATSEDYHRMRNDAEFGWLWGRRVVSFGDSVDRRAARYVCHEFGHDMVFPKLHEIEQWPMGVCHIPAFNLTFTAFHSAGGFTYRPEWFWYKQMRIIPFERRWEELWQPHERDIRGPNGRPDLILWQNGLWDQRGFQVGGQKLHEGQNVTLNARHRKMVWDELHFFLARTKKYAEMLIREFPDTPMMWRSLTYHQKTGSGDIMVVEMDRLGRALAEQYGHEVFEWGRIISLMGNWYEDGTHPGEGALSWLWGNMILEYLARSAKSKIGGDYRFPYFDGWERCHEELVGWGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPB4</accession>
    <name>S0DPB4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to CYC8-general repressor of transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426356.1">
        <property type="nucleotide sequence ID" value="XM_023572186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPB4"/>
    <dbReference type="STRING" id="1279085.S0DPB4"/>
    <dbReference type="GeneID" id="35397999"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04518"/>
    <dbReference type="HOGENOM" id="CLU_033652_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="463" mass="49770" checksum="E6982B3C5D34948B" modified="2013-09-18" version="1">MYSAGYGFSNNAAPSFNNPAPQQQSGAQPAAQQMMYNQQQQFAGMTPQGGFNPGANPQMMGAGPGGMMPNAGMQHMAANGQMAGFQQQFAGNPYGQVVPSSVAPQNFAPNYMMGGGMQGFPMNQPGMPQNPQMMQRLQQQQQAQAQAQQQQQQQQQQQQQQQQAANPAGMGQVSTPQRPPSAAQGTPNNALPSQQGQFPTPQPPSQSQTPTNQQSQQPQSQQQQQQTQQAPAQAQGQQPQQPVSAGLSTPQTPTFSTNQGPAANGTLTAAPLSPGTESRDKERFALLLDINHELLYESIQIQATQQELKKESAAAGNPADKKPTEEETQLQQDYLQCMRRLQANLSYMAALADRKPEVKVPPCPAYLTAPALTLSLKLRAPAVGPEGADNNIDPVADREERNNSIRDLYSRLQAVFPGIDPKREPAYRMNTQGGQKPGMMGSQASPTAQRTPKITNMGAPPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQL7</accession>
    <name>S0DQL7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426802.1">
        <property type="nucleotide sequence ID" value="XM_023572731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQL7"/>
    <dbReference type="GeneID" id="35397512"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04031"/>
    <dbReference type="HOGENOM" id="CLU_017513_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF37">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="179"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="572" mass="65379" checksum="8A2C630DC4BF5143" modified="2013-09-18" version="1">MGSISTSTHGAPDSEPILSDALWRERVPHINGENHFFWPYPILERLITRETITRQLHSVKIGLEDAEACSNLILGIDRPSFLRVFAILVIVERSGDIRAFIDADLHDERFPLVQGSEHYLTAQICMAKLGWSHMQKDYFNINQLRISPRFFSLGEDYEAQHYDMPKGQMLPWVLCRDSYGVHEETLSGGCGQVVKYKIDSNSHGFAPLLEELGFYGSFVAVKSLKNTSREKGTSNKELKMLKRFSGLSHPNIITLLATYTLNNRLHFIFPVAEYDLLMYWKIHPGPLVSPASANSEGLLWLSGQIRNILGALAHIHEGRKANMDTETMFGRHGDIKPANILWFRSRKERRGVFVISDFGIADAHREETRSIVSAVDLPVTPRYRAPECDIRDGRISRAYDVWSLGCVLLEMISWILGANELREQFKEILVSPYITGVKTDIYYDFHWLGPGEGYRVGVKEQILQWTRSLHNKPGCSPYVHDLLKIIHQDMLVVDQHRRKRMADLLDNVGEMHQRAVDNIDYIRAPEPSEVIMEARYMDGVRLNNKIESILENQEEKRKQLNEASHGEVSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQW8</accession>
    <name>S0DQW8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to 3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_03905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426917.1">
        <property type="nucleotide sequence ID" value="XM_023572871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQW8"/>
    <dbReference type="STRING" id="1279085.S0DQW8"/>
    <dbReference type="GeneID" id="35397386"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03905"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT64836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="279" mass="29419" checksum="349A67F1DA05D6AE" modified="2013-09-18" version="1">MTTYHIRDVDNRVEGRLALVTGSSGGIGSAIARALAAEGCDVVLHCNASLHKVEALSRELASAHPGKLFPCVSADLSSRDETRGLVDKVFQDSSISAKHKAVSILVANAGLGRRIRDIQNIEEDDWDSVMEVNARSQFVVVKACLPAMRAQSWGRVILVGSIASTGGGINGCHYAATKGALSSMGKNLSTVLAGEGVTVNTILPAMIGFTDMIPTPKETTWTRKTDLEELKETDPGLAIAASVPVRRLGHPSEVANIAVMMAKTGYLTGQDIILSGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRY5</accession>
    <name>S0DRY5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_02123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427281.1">
        <property type="nucleotide sequence ID" value="XM_023573819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRY5"/>
    <dbReference type="STRING" id="1279085.S0DRY5"/>
    <dbReference type="GeneID" id="35395606"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02123"/>
    <dbReference type="HOGENOM" id="CLU_022048_7_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="155"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT65200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="429" mass="48743" checksum="62DA12F6A601F7DC" modified="2013-09-18" version="1">MDTSSLMLALQLQHQDLNIWEQSKKGKQREGEVADSDLALEACRHELEMMTAQISDQVMALSIARAVESDGQLIREGQLAEEQAAKDREYAVRLARDPSAATRPDAEKGMRVSSVDEDEDNLIDTLRSMNLGGFEYSTSGQPESSGWASSRKPPQTQECIACNDRFPPLALSKAPCSHDYCRECLVSLTRSSLQDETLFPPRCCGQNIPIEQGRWFSPELVGQFQAKKLEFETPNRTYCSEPSCSTFVPPAFVSGDSATCPKCSRKTCTHCKGPNHFGVCPSDTASQQVLQLAAQNGWQQCYKCRKLVELNYGCYHITCRCSAEFCYVCGKKWRSCRCPLWEEGRLVRRANAIANRDGNFGQMNARAREARIEQERLNLIQNHECTHRTWNYRGGRHRCEECRDVLPHYIFECPQCHVMACRRCRYNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSB3</accession>
    <name>S0DSB3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FFUJ_00560</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425534.1">
        <property type="nucleotide sequence ID" value="XM_023573157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSB3"/>
    <dbReference type="STRING" id="1279085.S0DSB3"/>
    <dbReference type="GeneID" id="35394045"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00560"/>
    <dbReference type="HOGENOM" id="CLU_015869_0_1_1"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCT63453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="506" mass="56797" checksum="8B5B36E5C2D82AA9" modified="2013-09-18" version="1">MASKGRSYNDAIDALNSLQTPFDLVEARRKAGIRPDAVSIKEMQTYLHRIGYTPSDLNRLNIVHVAGTKGKGSTCAFVDSILSQYQHTRGTPRKTGFFTSPHLIAVRERIRINSTPISEDMFAKYFFQVWDRLESTPKDDSKKLMAPRPIYARYLTLMSWHVFLQEGIDVAIYETGIGGEFDATNVVEKPIASGISTLGIDHVFALGDTVAKIAWHKAGIMKTGSAAFTIEQVPDAEEVLKKRALEKNVGLKVLPVDPRLSSVQIRPDATFQKRNATLAIALAETALEKVGISLPPRTDTLPKEFMDGLEKVVWRGRCEVKKEDKVTWHVDGAHTSDSLKMSSKWFNDETSGRNGPRVMIFNQQGRSEAVDFLESVFKATRREGQPAFDHVIFCTNVTYAASGYKRDFVSRQFDPAEIDKMTVQQRFADKWMSLDPTATVKVMPTIEQSINYTRHLGEDLPEGETVQAFITGSLHLVGVPWEYWKTLMLYDLMIIERGAAFGGHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSM3</accession>
    <name>S0DSM3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_02500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427630.1">
        <property type="nucleotide sequence ID" value="XM_023574238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSM3"/>
    <dbReference type="STRING" id="1279085.S0DSM3"/>
    <dbReference type="GeneID" id="35395982"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02500"/>
    <dbReference type="HOGENOM" id="CLU_028431_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180020">
        <property type="term" value="F:membrane bending activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990809">
        <property type="term" value="P:endoplasmic reticulum tubular network membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032581">
        <property type="term" value="P:ER-dependent peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT65549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="169" mass="19197" checksum="F2F491D007DC5E31" modified="2013-09-18" version="1">MSAQDKAQQYLGQLDRELSKYPALNNLEKQAGVPKAYAAIGVGALYFFLIIFNLGGQLLTNFAGFVIPGYYSLGALFTHNKEDDTQWLTYWVVFSLFTVIESFVQVVYWFPFYYVFKFIFLLWLSLPAFRGAELIFRSFLAPTLGRYFQQTGSTASGLRAKADGLDKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSS2</accession>
    <name>S0DSS2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_02423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427561.1">
        <property type="nucleotide sequence ID" value="XM_023574152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSS2"/>
    <dbReference type="STRING" id="1279085.S0DSS2"/>
    <dbReference type="GeneID" id="35395905"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02423"/>
    <dbReference type="HOGENOM" id="CLU_052691_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT65480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="432" mass="46050" checksum="65779F2E94B86132" modified="2013-09-18" version="1">MFENTCTLPLSADVFATALHPTEPLLTVGLSSGHVETFRLPSSSSSDDNADADGDTSVLSDGKSMIESVWRTRRHKGSCRSLVYSHDGSAVYSAGTDALVKHFDPKTGQVISKFVIPSATTVPDAPTLLHVLNPQSLLLATDSGALHIIDLKDGKLGKKPVQTHFPHADYVSSITPLPPTSASTSGFPKQWVSTGGTTLAVTDVRRGVLVRSDDQEDELLSSCFVPGMGPKGHRNNGVLAVGSGSGVLTMWDKGAWDDQQERIIVDGDKKGGGESIDAMVLVPQELGLGKKVVCGVGDGSLRVVDLVLREVDISANLRHDHMESVVSLGFDCENRLISAGGRTVKLWEELSALQGGNDEDDEEDEDDDDDSDDSDAGENGNGKRAADSDSDDDSEEDQIAEMKRRAKRRKEAQQSKLGPMGAHGVMGFEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT18</accession>
    <name>S0DT18_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425824.1">
        <property type="nucleotide sequence ID" value="XM_023571535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DT18"/>
    <dbReference type="STRING" id="1279085.S0DT18"/>
    <dbReference type="GeneID" id="35398581"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05100"/>
    <dbReference type="HOGENOM" id="CLU_030426_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="387"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="546" mass="61003" checksum="E1349F458625793D" modified="2013-09-18" version="1">MESLQQQLQPDESEKRKPKEHKRSRIEVRLRSKPRDYVPGSGPPLQPISLLPPQDSTAYILERIILPSPGLAADGLPLPRRMTYIVSWTDLPAAQMLVPAMDILEYVSPRKLEEWEFKNTEEQLEEETTEKKKTEAGQVTQPKRRGRPPKHSTIETAVVAVVEDDEAVPMKGAMTIQTPTKNRLKDFEGLSDEEGPARQLQWEMTGDSAETDDQALKEHRGTVEDSESAFSGSKTDLVHSSAVKPQVPKKSHTKDKHFESFPSTGTSSRQSTPQITRIRSKSEGKKKLGRSSKKAQPSKGLLSGVQGTGSASDWTPQESLTYSNSGVETPDPESETQTARLIEEALSVQKKPPKSKSKPKSNTSKSPETVPQEDPSQEAEEADEPGWEVKRLEDMELYDVEGKGLVRYFLVRWEGDWPPDQNPSWEPESNLPKDLIKAYLRNGKRKRPDKPVTKPVSKQPSVTPSYAPKKKSMKQTTLSWGIPAKHFKSVSEAFAGGEEDELGMPVAADPRKDDDEDDELFVVEEPPAKKRAKKLDANGWGADDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT85</accession>
    <name>S0DT85_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable VPS68 Protein involved in vacuolar protein sorting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_02624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427742.1">
        <property type="nucleotide sequence ID" value="XM_023574378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DT85"/>
    <dbReference type="STRING" id="1279085.S0DT85"/>
    <dbReference type="GeneID" id="35396106"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02624"/>
    <dbReference type="HOGENOM" id="CLU_096876_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT65661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="171" mass="18846" checksum="486AE10690154246" modified="2013-09-18" version="1">MEEERLWKFRRPEWLNTVWARNAGVYSAGAIFSIAFYIMLDSAVWSKSSRNGSDIHVKFVDWLPFIFSSLGMLIINSVEKQRLSADSFSYSGNGVAWKARVVLFLGFAALAGGMAGGVTVFVLKFVVPSVAMPALGMGIENVLSNALVGVSSVVLWISQNMEDEYSYNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTP4</accession>
    <name>S0DTP4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04895</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426014.1">
        <property type="nucleotide sequence ID" value="XM_023571765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTP4"/>
    <dbReference type="STRING" id="1279085.S0DTP4"/>
    <dbReference type="GeneID" id="35398376"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04895"/>
    <dbReference type="HOGENOM" id="CLU_001882_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="88"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT63933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="553" mass="62360" checksum="E224E34FD4A6E7D9" modified="2013-09-18" version="1">MEGAAEQSKSALKKAEKQARLAAEKAAKAAKQTNLPVVGGKKADEIIGITVSKAENFPQWYQEVVLKAEMVEYYTEISGFFVLRPLAMHIWNEIRKWFQAHIEEMGVDETNFPMFLSSKSLEKEKDHVEGFAPELAWVTKAGDKDLEVPVAVRPTSEAVMYPYYAKWIRSHRDLPFRLNQWNSVVRWEAKQTTPFLRTREFLWQEGHTAHLTEELAGAEVLEILELYAGVYEKLLAVPVVRGRKTENEKFAGGYYTTTVEGYIPSNGRGIQGATSHALGQNFSKMFDITVEDPANKGSHIHVWQNSWGLSTRVIGVMVMIHGDDKGLVLPPRVAKTQVVIVPVGITKKTTPEERQKHEEQVEDIRANLKKAGVRVTSDWREGYTPAWKFNDWELKGVPLRIEFGPKDAAKGVVSTARRDTGEKGEIAITDVATKIPELLETIQADMYSKAEKSFREHRLTITKWEDVLPALDNKNVVLIPFCGAPKCEDRIKELTTREDQPDVPENQKLATMGMKSLCVPFEQPEGIVPGETKCLSPECQGNADKWTMFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU60</accession>
    <name>S0DU60_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426154.1">
        <property type="nucleotide sequence ID" value="XM_023571931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU60"/>
    <dbReference type="STRING" id="1279085.S0DU60"/>
    <dbReference type="GeneID" id="35398227"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04746"/>
    <dbReference type="HOGENOM" id="CLU_010107_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="888" mass="98258" checksum="24894B86576DDE26" modified="2013-09-18" version="1">MDDVADLVIAPFRDIVEKGREATQNAGDDKTMLKASQSLTKEGERALKKIEPLCRKHLDEYGSNFLDALKENGKSSFHPQPALLFRSTLIDFANPDEIAAFRTELNELLWEFDDYIELEDFEPKKFAELQALSRKAAPKVYDILMRLKLEVPYDHDSRSIMTRMSGSQSRPISPDAPPLPPIYPFSDLKKDIPRSASSLAESRTSNDPATVEAATAELRRMMQSRSGPDEGLYAESPRPSHTPQAILTPVEPPPRPPSGNPWDFNVKTSPKPRDNNFPEDFSFERRQPVAPIESPIEPISPPLSPDSGRELRPRPLKMGGDRSSQYSNDSQVSSLGMESGTYERTYSVFPTPRGRYSSHNSILSTSIPEDVVSERASTGYISQLSPTPRTVPPRSHSLPQSRPESVETNPGSVFDSGRHDGVTTPLTDNRESSYSVADGSPTLGTAELSPLPVKPPPVTNYQGMLEPVQPVMVPEVDNLPIPVETEITIPEHPPNPFAIDCKLNPQSSFYVHKGFCDGAKEILNGGAGVKKTVKAGFATVATIAKCVKCHFELDFNEIDLDVNKAERGNFIKNGIGYRLRFLQKSHLPTRRSDDVLYGCVFCITQGKTLHASDATVFISQKALFAHLARHPRPLPAVPGFTVIDQTEVPAEYKNDYDLHFKSPVEAHPAIEKADEISYLPTAISKEAARRMYGQRLLYDRTPALELVVNARVCGLTWPAKYLGEWAMGWYDGQWASVPTEIIKLDPPPSSQIKIDGTSPVQVTARWKFNQKDKVKGDWLKFDKDEVITNVSWTYQEFWCWSGTNSKGKTGIFPQAFIDIATLRGFGNSGSDRASIVSNERNKSLSVLSRFSSRKASRAGRPGSVAGSISSNETPSLPTPITSSASVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUK7</accession>
    <name>S0DUK7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_05295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427133.1">
        <property type="nucleotide sequence ID" value="XM_023571317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUK7"/>
    <dbReference type="STRING" id="1279085.S0DUK7"/>
    <dbReference type="GeneID" id="35398776"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05295"/>
    <dbReference type="HOGENOM" id="CLU_008891_6_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT65052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="529" mass="56955" checksum="B6199303CEC58C64" modified="2013-09-18" version="1">MLSFQPTQIFEEGTTEEKGENARLSAFVGAIAVGDLVKSTLGPKGMDKILQSASTAEIMVTNDGATILKSIALDNAAAKVLVNISKVQDDEVGDGTTSVAVLAAELLREAEKLVDKKIHPQTIIEGYRIASQAALKALEGSAVDHSKNPEAFRQDLLAIARTTLSSKVLAQDRKQFAELAVDAVLRLKSSDLNHIQIIKKAGGKLSDSYLDEGFILDKKIGVNQPKRLEKAKILVANTSMDTDKVKIFGARVKVGSTSKLAELEKAEKEKMKAKVEKIKAHGINCFINRQLIYNWPEQLFTDAGIMSIEHADFDGIERLALVTGGEIASTFDHPDQVKLGHCDVIEEVIIGEDTLIKFSGVAGGEACTIVLRGATEQLLDEAERSLHDALAVLSQTVKEPRTTLGGGCAEMLMAKAVEGAATRVEGKRQLAVSSFAIALRQLPTILADNAGLDSGDLVARLRKALYDGLTTYGLDLMTPGGGITDMRDLGVIESYKLKKAVVSSASEAAELLLRVDDIIRAAPRRRERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUT2</accession>
    <name>S0DUT2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427223.1">
        <property type="nucleotide sequence ID" value="XM_023571681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUT2"/>
    <dbReference type="STRING" id="1279085.S0DUT2"/>
    <dbReference type="GeneID" id="35398450"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04969"/>
    <dbReference type="HOGENOM" id="CLU_094271_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT65142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="153" mass="17477" checksum="4C9CF6D404756566" modified="2013-09-18" version="1">MGDRLTQLQDAVDQLATQFVACLHYVNKRHDLETLGPNDKVREVKDAPKEGMSEFMIHSKGNMLTSLIDSLPPDEFRAGMVELSQDLIVKEQQIEVLISSLPGLDNSEMDQERYIKELEEDLKIAEAQRQEAIKEKDQILSELDSVIRSIRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUX0</accession>
    <name>S0DUX0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428326.1">
        <property type="nucleotide sequence ID" value="XM_023575083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUX0"/>
    <dbReference type="STRING" id="1279085.S0DUX0"/>
    <dbReference type="GeneID" id="35396739"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03257"/>
    <dbReference type="HOGENOM" id="CLU_033337_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="430" mass="45795" checksum="8AAFE8F7C36359FD" modified="2013-09-18" version="1">MSSTSSALPGRQSHARTSSHSLLTGALNANHRVTRRKSVTNPNTNVTAIAAALRESERSSALPIGSGGRRMSKSAAARAALVGSLPSPPASLPNHKSIPETKQELNGSAIEDDVNEGSADEGTTKFQKARQRRASDGQTLKESKKSNRVEVRCDKCGKGYKHSSCLTKHLWEHTPEWALTSKLLISKHQQVQLLEAASVLVTMNGVENNADTPPESTKDFQSEAGSSSPAASGYSDPAERQSSADTTPPPFAEAVNVDGTSYRNKRFSSNGGYATSFQSASAASFGAGSVPYGSGFGHYRQPSHEHRPGSSGRNATGEDDRDLAAAVELLSCSFGSNNGSRPAMVPADAPPVPPLPAQYLDQAASLSASFINSFPSRQPESFTRGEMRRPSDDVRMEGSGDSVMDDDDFEMRSRGRSEDDDDGVFGRMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV51</accession>
    <name>S0DV51_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to galactinol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427353.1">
        <property type="nucleotide sequence ID" value="XM_023573909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV51"/>
    <dbReference type="STRING" id="1279085.S0DV51"/>
    <dbReference type="GeneID" id="35395687"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02205"/>
    <dbReference type="HOGENOM" id="CLU_049943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT65272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="314" mass="35337" checksum="16E0F75B67A83EB0" modified="2013-09-18" version="1">MVSENTATLPSKVWATLVTNDDYLKGVLTLNYRLRCVKSKYPLLVLYTSTLSQASVESLKRRGVAALQVPRLAPTTAKEYTDDPRFNECWTKLIAFSLTDYSRIVLLDSDMLPLQSMDELMDLDLDFPLLSGSGDTERSKRVFAACHACTCNPLRKPHYPPNWKPENCALTTQHVSPDTAQTTGADNSSGLGKLNSGLLVINPSKVIFDQIVTKLNEAGLDYQFPDQDLLADLFKGRWVALPYIYNALKTMRDPSVHGAIWRDDKVKNVHYILSPKPWDELGPDGTWKGDKPIHKWWIDAYKSMRAEEKTLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVV1</accession>
    <name>S0DVV1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428671.1">
        <property type="nucleotide sequence ID" value="XM_023575500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVV1"/>
    <dbReference type="STRING" id="1279085.S0DVV1"/>
    <dbReference type="GeneID" id="35397113"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03631"/>
    <dbReference type="HOGENOM" id="CLU_2158605_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="111" mass="12146" checksum="D3CB330A21261E48" modified="2013-09-18" version="1">MRLIPWSDCIGMGINDFIPTFIYIVQQLRALNVGFLDLIEELIRGNVNADCGRDNNVSFAVNAWGKQASVMISGGFNGEFAQKAVDETYKDYKLAIALVATGRATLICPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWJ4</accession>
    <name>S0DWJ4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to GTPase-activating protein beta-chimerin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427848.1">
        <property type="nucleotide sequence ID" value="XM_023574505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWJ4"/>
    <dbReference type="STRING" id="1279085.S0DWJ4"/>
    <dbReference type="GeneID" id="35396220"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02738"/>
    <dbReference type="HOGENOM" id="CLU_017095_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="444"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="737" mass="81926" checksum="EDC24372E64A8D3B" modified="2013-09-18" version="1">MGRKAAPQPLALSSQTSPQAQAQAQSQSESGAALRSRDDSPTAETVSPGVSPVESKSPRSPRSSPFHSRFSPLRNQGGKHRKASHTTSALADATAEGKPSSSTPPPQPSAPVPIPVQRPSTATTSTEWSREESVPRQPLRQTREDPSTYPSISSTLEDHLPDPLATTAATTQSKAIQQPIPSELKKGAKNGFFHFNKQNKSASQSQSHAHHRKQTETRAQVLSRGSDGSNRPRHGDKHDPSPSASYTEHTLHKPVSADPLRSDLSLSSAGDYDTVSPQSSTKKGRSKPFGLLNRSRSNRDKEDASPELNPASSRQGNEPELHLNSVPYKTTNQGGDRSIRDMMNSAVRNRSEDRAPRDSSSTRRAQRDKESKTQPSSLNENGGSFFNGLKTSGTRAAGMLSDRFFNKSGRGGREDKDALDDEHYQIKVINLPLVEQTRLTRISKRLEDSRDKTEFWMPAFPWRAIDYLNYKGCEVEGLYRVPGSGPQIKKWQRKFDEQFDVNLFNERDLYDINIIGSMLKAWLRELPDELFPKAAQDRIARECAGAEEVPELLIEELSNLSPFNYYLLFAITCHLSLLLAHSDKNKMDFRNLCICFQPCMKIDAFCFKFLVCDWRDCWRGCKNEAKYIEEEYMIFDQPPPKGLAEPAKPRPQDESEDDRQQLSSSGSSKQSGRLSPNDQQPKLKKKQLQISPSNGSVVSNESTAPTALTINSDRELGRTSSELRPLSPIMPLSPLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWJ6</accession>
    <name>S0DWJ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_13099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429010.1">
        <property type="nucleotide sequence ID" value="XM_023575744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWJ6"/>
    <dbReference type="STRING" id="1279085.S0DWJ6"/>
    <dbReference type="GeneID" id="35406555"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13099"/>
    <dbReference type="HOGENOM" id="CLU_031491_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF104">
        <property type="entry name" value="AT-RICH BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="378" mass="42420" checksum="D7A68D57F111E660" modified="2013-09-18" version="1">MVSEYKTGSGTLSSNRFWCEPCKRIFRTWQQLHDHKEKMSAQGKPKHIHCQFCGLDFHTEAAKITHIQQDHPQEQNLYCTGCGKGPFVRVGGLVTHVEKECLILSTKTIEAMREEKMGFSQALTALTQEPLKNNYGKYMPENADKGLPDATWESTGSIPAPFTIEQSQFPSLGESSSTALQPVKEKKENSWNQGKNLFPDAPAAQRPTQEQLKQVTAPSARTAYELMSEFDPKHPNFNVGRFYSEYTQKFNCRLGRCGKAFKTAKGLIAHLTSEAHSTSKYRCPYCLNTFGSLASITQHVESNSSKCHIRESEQFNAYMDQLLASLVDVKERHPDGTVRYETSKTFGKGPSPGSDLVQQKENPKVNGGDPYAGKKIHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWR0</accession>
    <name>S0DWR0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429017.1">
        <property type="nucleotide sequence ID" value="XM_023575755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWR0"/>
    <dbReference type="GeneID" id="35406564"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13109"/>
    <dbReference type="HOGENOM" id="CLU_2372951_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="95" mass="10173" checksum="E6721D68FB141AAA" modified="2013-09-18" version="1">MPLYARNVSAATRLRSAILRLDTCEDIPVKGKGTCDELPSAFEAKPALRALLDEHSDNPVPNVPVAFAGVTPVSRPSQSTPARRRGAAEPPRTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWY9</accession>
    <name>S0DWY9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_13239</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429140.1">
        <property type="nucleotide sequence ID" value="XM_023575901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWY9"/>
    <dbReference type="STRING" id="1279085.S0DWY9"/>
    <dbReference type="GeneID" id="35406693"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13239"/>
    <dbReference type="HOGENOM" id="CLU_011815_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000067">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="220"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="553"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT67059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="650" mass="72256" checksum="2580D145C2DA6CC2" modified="2013-09-18" version="1">MPQKRKRPDQDPSEQELLPASALKSTSSDSQSKSTGARRATRQTPVIPPTPVTQLQPQPRTETAVPPPIIPTLSSASSKPTTSPEQKRSRASNGRPQLPSSQPTTQSQHPPSVLRWAPLEQPGPAVRPPPHHLHPTTMAAMPPPRPIAAGRPPSDLVAPEITYHVPQSHTNSFQRTSALVRPHGPTAQPPRILERPPPPTVTPVHPPKPPVPPSVRPPLRADRNIDKVVLGNMCFSTWYPSYYGKEVLGESSGNLGKIGSKDLGAKDQATGGKSSSRRDREHHPVVDRLYVCPTCFKYSKELVAWCHHVHVCERKTQMPGRKVYTHPRGRRKILVPHDNKTSGPKRRKGEGNIRLVEEIVQDEGEWSVWEVDGEKDGLFCQNLSLFAKLFLDNKSVFFDVTGFNYFLLVYTPPSRSSQTATEHEPEPPSPRITGFFSKEKMSWDNNNLACILIFPPWQRKGLGALLMGASYEISRREGILGGPEKPISDLGKKGYKRYWAGEIARWLLTINMDSKTPQKEVLVDLSDCSKATWILPEDCLQVLRDMGVVEEAGLGPRKPEEKPVREAEAEEKKGEDTTRTSPTADGGAKEETVPVVKMVPRIRIDKQAVRRYVAENRISLERMCDPAGFVEGYAIKAPEVVEEEVVEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX13</accession>
    <name>S0DX13_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to spore coat protein SP96</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429180.1">
        <property type="nucleotide sequence ID" value="XM_023575950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX13"/>
    <dbReference type="STRING" id="1279085.S0DX13"/>
    <dbReference type="GeneID" id="35406736"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13282"/>
    <dbReference type="HOGENOM" id="CLU_032571_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484620" evidence="2">
        <location>
            <begin position="18"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="404" mass="40914" checksum="1B2C33271F93548A" modified="2013-09-18" version="1">MFAKAFTIATMASFASAHMLMANPKPYGNPNNFPLAADGSDFPCKGKVNDGSGDNVYKQGSTQQLSFTGQAVHGGGSCQISLTTDKNPTKDSVWKVIKSIEGGCPAKGQEGNMGDNADAPDPYKYDFTIPKELAAGEYTLAWTWFNKIGNREMYMNCAAVTIEGSGGSKDHLNTLPDMFVANVGNQCETPSAKDLVFPNPGNDVDKFNGATEAWGAPDGTGCKTEAGSAPTGGNGTSAPTGGNDTPEPTSNSGSEPTQSAQPQPTQPAASPSSGSGSGSGGASEIPGGAFITVSQPAASQPSATEAPAAPENPKEGSGSGSGEGSQDGDSGSGSGGFAAGTACTNEGEWNCIGGSTFQRCASGAWTTAQQLSSGVTCTPGQGADIAMTTKRGKRDMRRAIRAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXP5</accession>
    <name>S0DXP5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427324.1">
        <property type="nucleotide sequence ID" value="XM_023573874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXP5"/>
    <dbReference type="STRING" id="1279085.S0DXP5"/>
    <dbReference type="GeneID" id="35395656"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02174"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013438092" evidence="2">
        <location>
            <begin position="20"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="448" mass="47439" checksum="EFC80C5056452826" modified="2013-09-18" version="1">MFPRFILLSVAALSTLGLSVPVEERQQPVLPTEDSFYRVPGNINDYPPGTIIDYRKPPSPIAAFGISPTNLKDTWQISYRTNDNFGKALSTVLTVLVPYKADYTKVLSYQVAEDASYAGCAPSYAFQFASATGGPLGTIVTQAELLLIEAALEQGWIVISPDHEGPDAAYLANKLAGYATLDGIRAAINSANFTGISKNPTVGMWGYSGGSIASASAAELQQFYAPELRIAGAALGGTVPNITTVIKSINKGPLAGIIPPGMVGLAKQYPLLKLGLDAAVKPEYKAKFDAVEKQCFVADIVSFLGQDVVGMLKDPAILTQEPAKSILDENALGKHSPSIPLFVYKSIQDEVSPIKDTDNLVKFYCSGGTKVQYDRDLLSEHGSLAIIGAGKALAWLKDIMNGRKGPGQCKTSNVVSSLLDLRGSITLSTALIEALADLVGKPVGPIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXU6</accession>
    <name>S0DXU6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429442.1">
        <property type="nucleotide sequence ID" value="XM_023576268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXU6"/>
    <dbReference type="STRING" id="1279085.S0DXU6"/>
    <dbReference type="GeneID" id="35407022"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13568"/>
    <dbReference type="HOGENOM" id="CLU_027089_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485028" evidence="7">
        <location>
            <begin position="23"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="515" mass="54147" checksum="6F33987D94D6BCF1" modified="2013-09-18" version="1">MHTSALSLAGWGLVFSAASAAASNVHIAPRATQAPSTTAANPEVTTITGCHLHASGLYCFAGETEYLVDVKVTATTDVPSQYTDCHSHGSDMFCVDSDGADVSVQAEGAESEEDHAKEDEDHDHDHDHEEASGTGSAAAAGNTKEAENEHCHFHAGVEHCTGHSDSESSETESGSSSSACQPRRRDYDVGLRVGLLFVILATGALGVFGPILLHKMMPSKLNIVLIVLKQFGTGIIISTAFVHLYTHAFLMFGNQCIGELGYEATTSALVMAGIFLSFLVEYIGNRIVLAKTKASANLSGAERKSAWLSTEVVSVLVMEMGILFHSLLIGLTLVVAGDEYFLTLFVVILFHQMFEGIALGSRIATIGTSNDSHAPPVARISQDTSSAQDSDKAPASTETIPNEESTPVGLTMKKKLGLASLFAFITPIGMAIGIGVLQQFNGNDKSTLIAIGTLDAVSAGILMWVGLVEMWAADWMSGGHGHKAELADANLLTTILAGTGLVAGLVVMSLLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXY8</accession>
    <name>S0DXY8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429401.1">
        <property type="nucleotide sequence ID" value="XM_023576216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXY8"/>
    <dbReference type="GeneID" id="35406976"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13522"/>
    <dbReference type="HOGENOM" id="CLU_092474_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="157" mass="17203" checksum="64880FD9382823AE" modified="2013-09-18" version="1">MSNDDDYMAFLNKANQDTGAGAATQEKTTFKTKDQGAQVPKPISDVCKNAVYTSDADEPFQEVSLKWEGKNGLPSESEFAKLINHSSPDSADIKILDPLNWDSHGKHTDVIEAVREASQGNDVRVYQVTRDATRTEYWVVSHADGKLIGAKALSVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY60</accession>
    <name>S0DY60_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429565.1">
        <property type="nucleotide sequence ID" value="XM_023576414.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DY60"/>
    <dbReference type="GeneID" id="35407154"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13700"/>
    <dbReference type="HOGENOM" id="CLU_002657_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055795">
        <property type="entry name" value="DUF7371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF1">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN RRT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24086">
        <property type="entry name" value="DUF7371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7371" evidence="3">
        <location>
            <begin position="1534"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1406"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1500"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1759" mass="181036" checksum="9C83085B26067FB4" modified="2013-09-18" version="1">MPSNGSYQNSNHPHIGPWTGPTHRPWLYLKRAGVAASYPLRGIWFFIQNREFWPLLVGRILPISLISFLVYLLLFTFAFLPQYAFLAIFHGWGAWVNAVVLVLGEGLVIIQGLFEGFFVDECRVDVFDAALIKLGHKDLIAPQRILFLDAPNPVRMLGKPTTAAIYTPWSIIQIVELIVFLPLNLVPIVGTPAFIIITGTRLGKLAHYRWFQIKGFSKAEQKKALRDRAWEYVWFGTVAMILELIPVLSLFFLLTTTAGAAQWTARIEEESRGPAENTAANGQTYQNDAHEDPHPDAPPPYTDYSDDVGGNCRLAAASRAPSSSCRDFLSHWLAQLLNERVIPNILPLQEEGTPALVPLVPGIHRIYPSPLDLVPKTFSSLLHHTSSSFLFILNPPQFEKRHLLSPLVSVAFIFKLSLLSFSGKAFYTCPPTEIISHFLSSLYTPLNCSTFFASKLITQDANPNGSPVGSSPGGSGNIIPGNTDGSGNPSYPSSATGNVPGPLPSSVGPGSTDGGSNGLPPNGPSGVPGGVPGGVPGGIPGNLPGNSSPNIPGAGSIIVPGSFPTNAPQNMPGSPGSPNAGGSDLPTCSLRSTKTVVVTVYPTDTQDGQDFPWPDDSDSDGSEFPSPFPTTPADFTSLMLASSVPPFTTLTLDIWGPDGSPSSSGSGSDDGTGSGDSSNPEDGNGTDNGNSVGGVNDPSDGSDSSNSGPNSGSESGVSNSSGSDGENSSQNNSDSPSFSQTPGSNGAPGYSDGAPGDDSSVGFPGASGANTAAPTPFPGPGSPSNGGVPGSQPQFPSAMPPQEASDSLPVTTQAGPQGQGENSPWFTNVPGGNDAGQPIPSFITITGQDGLPTIVSSGSNVGPGQEQPSATPGFTQSGNNPGLPGGVPTVFPLPSAVSAGLPGSQSPSNSQAGSLPGSGPGGGITTCATFTITGTDGLPTVIDSTWVVPYSTPSFEDSSQLPVTGIPQASLSGIPIDVGSIPTGPISAPGIPHDGSGGSGSSTCTSYTIIGTDGLPTVVHSTWAVPVTGSDPDSGHPSGAPGSESSGGFLTISGLSTFGPDDIPGSLSTTSNLGGAIPVTTSTSYTIVSADGLPTVVGTTLVIPGPTTTDPSISTGTKEPSWASDSLPNGVTSAITMQTTGAPELPSSGPSDASGSDDGSEGIATCTSYTTIGPDGFPTIVDSTWVISGSANTRSESPSNPSFVSDSLTSGLPTGNPGPVTSSPGLPSNGNDGEVSGLSTCITYTVIGTNGLPTVVDSTFAVPTGTENPAGASLTDDQTDSSLGSPKAFTTITTAVVLGPDGKPTPIEQTIVFSDSSALGISADVPQATSSGITPPSNSEPVFTTGDLGPLSTSIPTLNGYNDGMPEDSISVILTDASADAQGTSASGTTTGTFTWTVTSVVDTSNGPVFSDGAEQPPFTSNPSGDGSSDQLPQTAYGPVASENTLWPLSAGTATLQTTTWTNVIKDETTSYTIDYPLTTLATVTVPRKRFFRRQGMSWSNTTASDSSVTSPTATETTSKASSPSICATGGSIGNTTIDFDNSKPGPLFNPVENIWFSGGFLIAPPSSRQSQPYIPTSGGQLVEFVPPALSNTTSTISGDVAQIGVGPHAASPCFRFDLFGASLGCDAHGDEKWCEFEISAYRWNETSSTEESIAWSETKQVPACPTFSEGGYELNRVDLDGYTDLSSVLITVRVSQNLRVWWGDDFRVGWTDNSCIAASCRTNVPSQLVKRETVFSALRQGVYQWTPHELKRLEDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYW5</accession>
    <name>S0DYW5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to CDC4-cell division control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429696.1">
        <property type="nucleotide sequence ID" value="XM_023576511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYW5"/>
    <dbReference type="STRING" id="1279085.S0DYW5"/>
    <dbReference type="GeneID" id="35407944"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14563"/>
    <dbReference type="HOGENOM" id="CLU_000288_103_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="442"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="690"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="806"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="846"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="888"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115022" checksum="73028F6920E1C747" modified="2013-09-18" version="1">MTPSPATSQALEPRHSKPSQTVSVNISEGTQNRSRRFQLEVSECVETKTVTTTTRLTRKFPQVFVRDPVPLENLDTKEYPLAMKPTPPELIRFSYNMPGAIETDDEVEDEPIDHQLSCNSRSTPTQLKSESPQESNLVRIPKHRSQSPSEGYSRRSRASRATTIDSPETSAPTSNPRRPGRSIPLNAVSDKLRRSIAHNSNRQGERSSRPSGGFLATPDTSEVVGAVERLARRRSSHHERNQSPEASSSAVSPQYEATSPVESDSHTVFSSNVATPPITDADAEPFADADGSLQQPIRPFNPRPSIDVVAAQDASLPSPRLSPTLAAAQLHTADDEDETRPSFQSSNLDPSRWLDESQPMEDDSLTALVRTGHSQDDYALARTDGAPQGVDSLQVVDTQTLLEAFDSMKTEMKTFMMYQFLRRCPRPTLRVVANAVNPALKCDFLRQLPLELGYSVLSHLDHRDLCRAAQVSKHWRNIVDRNETGWKELFDRDGYTLPPGELQKAIIQGWGWQDPVGASGYEKDLSMRTRLTSTEHELTRTLRQETASKSRASKRKRAINTYSAERSKRRASAQEAVAREENKSQPEARQHKSEGPLSAANAAATAVPDPQLGLPSLRELHLYKSLYRRHHMIRKSWTSGEVKPGHVAFAAHPRHVITCLQFDEDKIITGSDDTLIHIYDTKTGKLRKKLEGHEGGVWALQYEGNMLVSGSTDRSVRVWDIERGLCQQVFYGHTSTVRCLQILMPTETGRDSSGQAIMQPEKPLIITGSRDSQLRVWRLPEVGSRRYIQTGPPAHESDCPYFIRVLAGHTHSVRAISAHGDTLVSGSYDSTVRVWRISTGEALHVLHGHSQKVYSVVLDHERNRCISGSMDSLVKIWDLATGACLYTLEGHSLLVGLLDLRDERLVSAAADSTLRIWDPENGKCRNTLMAHTGAITCFQHDGRKVISGSEKTVKMWDVRTGECVQDLLSDLSGVWQVKFDDRRCVAAVQRDSLTYVEILDFGAVRDGKPPEELGKRILLNEPEVRAMIEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E037</accession>
    <name>S0E037_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_07000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430309.1">
        <property type="nucleotide sequence ID" value="XM_023577203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E037"/>
    <dbReference type="STRING" id="1279085.S0E037"/>
    <dbReference type="GeneID" id="35400477"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07000"/>
    <dbReference type="HOGENOM" id="CLU_031387_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF17">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT68229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="496" mass="55825" checksum="4831B9D5C3310CAB" modified="2013-09-18" version="1">MPPKKRAYVPKTKGCHECSKRRIHCDGNEPSCNKCTSRGLSCSGLGIRHRFNKGVAARGKWAGKTIDRVYEENEWKVPSTDKDASPSSALSSAADTNPETSESHHDDNGDIHDDDIEYITSDTGIYDLVLANSQSTADREVFMTLFFKGVPDNMPAWKRNLFMTFSRCISTEMVAIDGLHNDWRHLLLPLAQQDELVMDAVLTVSAFHFHINKLDSNFKKNQKQYSAFGTNTYDTYVPDPYQLLGRTLQGLRQRQELICNNQTTQHSVLISLLLLMTSVLVTGGSDFPVLLRMLESALDAIGGKEGLGTGILAGFIMRELHKIRVYAAPHLGEEIGLQMISSQARTDQLFGCLNHCLQLYPEHTPLLSQVTSLVYQARDIYLQQVLSDHTSNFFDLDPIPTNPESVARVQRFIEALEQFPETSPVTQMLVWTTFVAASDAQLEEHKVYFENVLRRHHARSGFGNLLKGIEALKRMWSRKPGEKWTTLLPQTKVLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0I7</accession>
    <name>S0E0I7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_03233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428304.1">
        <property type="nucleotide sequence ID" value="XM_023575057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0I7"/>
    <dbReference type="STRING" id="1279085.S0E0I7"/>
    <dbReference type="GeneID" id="35396715"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03233"/>
    <dbReference type="HOGENOM" id="CLU_036926_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="243"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT66223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="461" mass="51928" checksum="C807C48A2B8D1D20" modified="2013-09-18" version="1">MDIVHDAPIQENLARSAAPEFDFRFQLVSVSGSEEIQIPAHTCMLLDCQNRLSFVGRSTAHSFMHHIRNTIEKRNGPSEFTADSNWSGLPERLPVTPRMQSFLPPSTTASLIEFYFNHVRSFIDIVNPEAVSLTLYRFQNNPNEVQGPDRCIFYLVLAVALALDSGDSAHSPSPEFKHQLFAIAEGLAHPTRTFEKSQYHDDVLWPLQALALMSFFMLSVSMRNTAYEYCGKSRRTCMRTNEANNSSGRAVRVAYALGIHRGHESEISQFPANEELRVLRRNVWRSLFILDRFLAATLGRPFAIADNEYSESSLQPPSRPSSPNKVPKRDMLDPPIDACKMIGHIVNNIYSCDKVAIEIPNQMLGYLEAHPSFQEDGFFTISSLMPTVSQIHVRLLSFYANILLCRPFFLLSFMGINASDGTQTQINRLSERCVSQSLQAVEMVKGGFHANLLRHSDPLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E195</accession>
    <name>S0E195_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to sorbitol utilization protein sou1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430704.1">
        <property type="nucleotide sequence ID" value="XM_023577676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E195"/>
    <dbReference type="STRING" id="1279085.S0E195"/>
    <dbReference type="GeneID" id="35400902"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07425"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="294" mass="31761" checksum="C69006F08C4F5797" modified="2013-09-18" version="1">MSDLNPLNGGNFVHDNNRVVDGGSILKRFSLQGKTAIITGAAAGIGLSIAEAYAEVGANIAIWYRTSSKAEERAEELSKKYNVLVRAYQVDMRDAEAVEKAVDQSIKDLNGRLDIFVANAGIPWTKGPMIDGPLDHYRDVVQTNLDGTYFSAKAAAKHWRRQKVEGTDTNGQPLTNYTSGSFIATASMSGSIVNTPQLQAAYNAAKAGVIHLIKSLAVEWARYARANAISPGYIITEISNFVPQETKDIWKDKIPLGREGEPHELQGAYLFLASDASTYATGANFVIDGGYSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1Y9</accession>
    <name>S0E1Y9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02131</name>
        <name evidence="3" type="ORF">FFUJ_13725</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="0" first="0" last="0">
            <title>Deciphering the Cryptic Genome: Genome-wide Analyses of the Rice Pathogen Fusarium fujikuroi Reveal Complex Regulation of Secondary Metabolism and Novel Metabolites .</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M.K."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J."/>
                <person name="Huss K."/>
                <person name="Michielse C."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 58289</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2013-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="MIPS"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 58289</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428759.1">
        <property type="nucleotide sequence ID" value="XM_023573827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1Y9"/>
    <dbReference type="STRING" id="1279085.S0E1Y9"/>
    <dbReference type="GeneID" id="35395614"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02131"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13725"/>
    <dbReference type="HOGENOM" id="CLU_694536_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="371" mass="43095" checksum="513FAC73577C07DA" modified="2013-09-18" version="1">MPPSTGKGYLLNGPADWDSFEQSYIMKVSAERVYELGRLNTPAQFIDKRITEPRRPEFSDYLAREQNEARSRSTNSSQSTVRSSDPATSYVELVPEDQEAYKASMAIYKSDLDRYNKQADGIRNVLNWMIEKINPHYVETCSPAMNESTQHDNISMFYTNLKAARTNWEDWITSWEKAMRIAKLRGVAEAQHSNTWFEDLQQNLDVQFRIFLRIEQGQNKDAIEAGTYLPLTFSAQFRQEIQSMKRRSDRNPRNQVAKGSFKTTFQDSSPEIRKRSRSSTGETKISPGREGSAKRPRASIELELCILCEKKHKNANTTSCWVAFPEKAPKKYPTSQRQLDLWEQRLEDKKEVRELFEKLQQEKQDSKEKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E242</accession>
    <name>S0E242_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to S-M checkpoint control protein rad4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="Sieber C.M."/>
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                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
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                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
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                <person name="Proctor R.H."/>
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                <person name="Freitag M."/>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
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                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
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                <person name="Proctor R.H."/>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="Espino J.J."/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT68097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="574" mass="64294" checksum="FA0C654665EDA5C7" modified="2013-09-18" version="1">MSLLDALDSSSTRVLLGCLLLAGIAYTLHRSMLPRPLADIPYNVSATNRILGDLPDVKAFGSLTDWLATQAIKHQSPLFQAFIRPFGKPWVVVADHYEAAEICTHRVKEFDRGTSSTAVFNCVVPGAHITLSSSDPQFRKNKELVRNLMTPSFLSEVSAPEIYDKFSRLVELWGMKTEQANGQFFSASKDVHNAALDIIVCAAFGLDTQHTQLVKEIQELTPDNTSSTKIGGEVAFKKLPLNEELNALATVAESVAKIIKTPSPPLFHWMYRSFSTTLKNAFVLTKQLQEREIANGIKRRANGEAMKCALDEISVREEGLAKKEGREPDYYSQVITSEMMTYLIGGHETTSSAVRWGLSYLSAEQRAQSELRNALQQAYPQAKFERRVPSLSEIIQTRVPYLDAVVEEILRLSYPFGMTLREVQVDTQILGARVPKGTTVVFLSNGPSILSPPINFDESRSSEWVKSRKPKPLEKDYDYSSFKPERWLKTAIGPDGKEDVSFDSQAFPIQAFGLGPRGCFGRRMSYLEMKIFFTLVIWTFELLPLPDEVARPKPVSSLTRNPDKVFIKPRKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3N6</accession>
    <name>S0E3N6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431524.1">
        <property type="nucleotide sequence ID" value="XM_023578529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3N6"/>
    <dbReference type="STRING" id="1279085.S0E3N6"/>
    <dbReference type="GeneID" id="35398809"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05330"/>
    <dbReference type="HOGENOM" id="CLU_089373_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="236" mass="27142" checksum="93967ADCDD126726" modified="2013-09-18" version="1">MAQPVVDNQHYPSWINNNVFRQARFQGDPQYNHKKFEHALDIINNIAQHWAEAEVEGVKFRITRGKETDFRFRDVPIDIETRPNEEFVHRCENDVLEDENLNNASLAAVREYFRTWNPSKGCKSDVGNTRYVACIMLDAETLSQIATAPKGFPHGFGVYSSSSWVKMVDVEPTPDEAVYVRVRGADDLIKYWFIRNLIRSHVLTHRKDRDYPGVLHFGDPPSEGFEAFGGPPLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4B3</accession>
    <name>S0E4B3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_05401</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431590.1">
        <property type="nucleotide sequence ID" value="XM_023578608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4B3"/>
    <dbReference type="STRING" id="1279085.S0E4B3"/>
    <dbReference type="GeneID" id="35398880"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05401"/>
    <dbReference type="HOGENOM" id="CLU_026244_1_2_1"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="79"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT69510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="438" mass="49781" checksum="489882BC95987C5C" modified="2013-09-18" version="1">MSISVSPSFIHYLFSAAGVAALISLLARYLSQSRSHKDPVPAFLIDTTSTARALPASWYRSPEVYELERRAIFAKKWILTTHKLRFTEPGSWVKFEQAGFQFFLVKNKQGQINGFHNICRHRAFPIMTEDKGKSSILSCKYHGWSYGLNGQLAKAPGYDDMKGFDKTKNGLLPVHVHVDAKGFIWVNLDSSKTPEDFSTEFKNIDQMARHEGFNFEDYHFDHTWGMSGDYNWKTLADNYNECYHCKTAHPDAADVADLSAYRVDTKGGNIEHFANTKSEMEEQGLKIVSNYYFPNACMTVSPNFFYMMRCVPTSPGHCSMEYEVYRHKNATDEGFQTIDAMFKRILAEDKWLCNNAQKNLNAGVFVNGEMHPKMEQGPLYFQHRVRGILNDHFQLEKVVGKEINPAQHVPSDASRGTESDMGFCSGLACGENAEQLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4P5</accession>
    <name>S0E4P5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl hydrolases family 39 N-terminal catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_05526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431705.1">
        <property type="nucleotide sequence ID" value="XM_023578746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4P5"/>
    <dbReference type="STRING" id="1279085.S0E4P5"/>
    <dbReference type="GeneID" id="35399005"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05526"/>
    <dbReference type="HOGENOM" id="CLU_023231_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049166">
        <property type="entry name" value="GH39_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 39 N-terminal catalytic" evidence="4">
        <location>
            <begin position="153"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT69625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="455" mass="50662" checksum="1AEE5CC33DDD18E5" modified="2013-09-18" version="1">MLKSLPSEVDKVKDPVVSVATVDVGVQTGPPRHLASGILYGIPDKPDQIPDHFYKAIGFNYGRGGGSQLPGTKGYAVSLADYEARFASALSNYRTTRKHGGEFIYLLPAAWGADGGQSEGFAYPGDDNNWTSWDEFLERTLDDVKKSDMIEGLVVDIWNEPDLSFFWNRSMEQWLELWTRSFKKIREVLPSVRITGPSISAIPSASHEWWSAFLSRCKDSLPDQWSWHMEGGEEAITMASSMASFHDMLSKHGIPLEKAQDVNINEYAVYGEQVPSAGAWWIAGLERENAHGLRGNWAIAGALHDFMAGLLSKPNGSDGSYAIEGEGYWPTAEYQVYKYYASSMKGQRLKTTASSDGLLDVYATVEKDVVRILAGTRSRPGNWSIDVVGLTDDTRVKVKTLAFRVVDGDRFKRVDGPLDLEEREERVKGGKLSLKMKHQDPTTAFAFELTIVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E522</accession>
    <name>S0E522_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to Calcium_related spray protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_05700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431865.1">
        <property type="nucleotide sequence ID" value="XM_023578941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E522"/>
    <dbReference type="STRING" id="1279085.S0E522"/>
    <dbReference type="GeneID" id="35399179"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05700"/>
    <dbReference type="HOGENOM" id="CLU_009253_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF7">
        <property type="entry name" value="TRP-LIKE ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495525" evidence="9">
        <location>
            <begin position="27"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="51"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="764"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="821"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="866"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="908"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT69785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="935" mass="103406" checksum="E78A300A5F9B4B9F" modified="2013-09-18" version="1">MFAAQRPLAALSCLLSALSVIPNVCAQDKVYINGTGDNGVFHERLDVSRTPSLYTGDFDDCLNDGSLFNVTGFDTAYYSDNLTVSFHVYGSTNIRQESVMMHLSIEVYGEERFNKTYDPCAENVTSLCPLKAGQPIEAYITTSISANDIAGIPSIALNIPDLEGYSRIRIFANSTQTEIGCFQATMSNGRTFSQPEIVGSILGAFTAFAVLASFATAIYGVQIPHIRMHYAHSFSILIIFETFQSIFFSGALSVNWPALLPAWWSNFAWTAGMFASLDMIDAISPFAGVSGNASQVGSAGSVPINNGGGLAQQIFGRSLGSRSVPQLESVVHSLTRRHDFNSSNPYDYGWAGEPRNPGMPLPGDYSGFPGVLSVVGIPRNDAFIIGLIWFLVILAAVALFVATSKFVLELCHKFKLIKSDGFDFFRSHWVGYMAAGLLRTLFIAFFVMMTLAMFQFSINGPPGPTAIAAVIFVMFLGFAGLTAYACSSRLREGKYEVVSDTLRFEQGLVLKKIPFVATTLASSIGEEEQAHKPRLFASLPIRRIKFVDKDPERPRVHQDEPYIKRYGWLSARYRLSRWWFFTVYLAYQFVRACFIGGGRASPLAQVYGLFVFELVALVIIIKLKPFEGSRNTTAAIWLLSISKIITTGLSIAFLRTLDLSRVAATAIGMIILVVQCFLAAAILVLIVLGMISSWMSLSRNREDFPDKIDDLRVRYFEHMEDRAGTSKPKEDEVDELAELSKSIFSVSNVRRNTQINAFPMVEGANSQVPSHPAHPLNRRRANSGGSSRHSVNSLPRSGRTHRASWSAKDFAEWDADMNRGDTSRMSRMRTSSLRMQASRYSGSRPPMTPTRESAEFPRTSVNTMSPEDKDAIVKDKIEENAATPKRRKRAVSWADQSSICEEPINEAQKVDDKPLEKIDSTGGREEEEAKPKSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5E1</accession>
    <name>S0E5E1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to acyl-CoA thiolesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432060.1">
        <property type="nucleotide sequence ID" value="XM_023579176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5E1"/>
    <dbReference type="STRING" id="1279085.S0E5E1"/>
    <dbReference type="GeneID" id="35399389"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05911"/>
    <dbReference type="HOGENOM" id="CLU_032690_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000074">
        <property type="entry name" value="Acyl-CoA thioesterase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="2">
        <location>
            <begin position="47"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="3">
        <location>
            <begin position="159"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="353" mass="39506" checksum="114FF24B41038049" modified="2013-09-18" version="1">MTVIEDHVRPTLLRPPEHDESKSLIENVLDVTEIKVLGPDIFTNTQPQWHPPGARGIYGGAVIAQCLAAAQKTVPETFLVHSCHCYFLLAGNSEIPILYHVERVRDGRSYSTRTVQARQKGACIFTTTISFVRETPPEKKRREVSHAASLPKDVSPPSEDWDGEPEWARTGPFQSHRIEVLGAQDPNCKPQDRKSRQWMRSRQKISAGGGHQAHLNALAYMSDSYFIGTVSRLHGLWRFPFSPQEVPSLDEKTQEQVKSLCEFEGMGSNVEDWKGRAQVGMLVSLDHSIYFHEPLAVKADEWMFTEMESPWAGDGRGVVTQKIFGRDGALLATCFQEGVVRLKQDGGEKGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5Y6</accession>
    <name>S0E5Y6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to sensory transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_06274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432393.1">
        <property type="nucleotide sequence ID" value="XM_023579581.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E5Y6"/>
    <dbReference type="GeneID" id="35399751"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06274"/>
    <dbReference type="HOGENOM" id="CLU_000445_82_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="560"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="864"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1209"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="895"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="895"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="909"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1372" mass="152600" checksum="DA0B70E89829F5D6" modified="2013-09-18" version="1">MPPPALQHLGLIDLVASDPRPTFVVALPEQTSSNISHYSADILYRNPALQNSYTLDHSIASIPQDVSHSPFWNWVTSPPSAPTSHTDATGPAPTNTQHSLPYLGVYWTRSIVLGQWVVMSGNETPPSSEPPRKVRIEGKEGETTRRYPQKSPLDNARLPSRKKSESKTPLHYRDESNPGLMVPVSDSEAEPFLDVVQNVDWESTSLGPMSDWPAQLQHTFNQLVSDSRPVALYWGPEYVTIYNEAFSKYCGARHPGLLGRPAPEAWPHLKTRLDEMTASPSKNYSNAEDESKFFIPMADGSHEETYVKSSMVPIVYDKKCLGIQHSLLEMTSRRLWERRMKMLIDLGEALVSTKDAKSYWSRTIEELERWSPTYDVPLAFLYSVADDESEITLSKYDCPKICHLEGSLGVPEGHAIAPQVLSLRETDEGMAFVMRKSLDHRQPILLQTKDDTLPKNLLHGLAWRGFGDPCQAAIVLPIRPTKEENAMGILFLGLNPRRPYDNDYRQFISLLNQKLTSSLASTVLLEEEARRRRNITEQAAYDNAMLKQRLEYQTEQAERSMQTFTAVADFIPVGMCFVDVEGNITFANDAWHRITGCPRGPIVQSALLESVLEEDKQKVIQAYKDVQKVDTVTFEYRIARNGNTADSKSFMSSTSSLSSNGERVLRHILASTKAERAPDGSVIRILTCLTDVTVQKDTAEEAVRRAQEAENLKRLAEFATVGMYDVSMDGRLLSANNLFWELTDLEKVDLTKTDVRPWPECVVNEDLHILQESLDKLVVSGRTETAEFRLRNGLVTEDSNGNSAVAPRWVLATFMPVRSSDGVIQSFTGCLSDVSIQKWQLEQEKLRKEEAIESKRQQENFIDMTSHEMRNPLSAILHCTDAIIASLARVQDISDNSAPLTPTRSGSQGDERSMGERSVEEKKLLEDSIENAETIVTCAQHQKRIVDDILTMSKLDSKLLAVTPCTVDPIEIVNGALKMFEVEARRVDIELTSYVDKSYKDLAYDYLDLDPSRVQQVLINLLTNALKFTKSGTTRHVTVGVKGSLEPPGEAMTVVQFIPRFCDVSEEYDQPALKGRTRPVYLLFEVKDTGQGLTVEEMGSLFNKFVQASAKTHTKYGGSGLGLFISRRLTELQNGAIGVSSQPGVGSTFAFYIEAFVPSEASRNEALAAAAAARLITGADGAEADGKRPCRDIRLQKHQNPGGNVRLDGILVVEDNLINQQITRRGLTDRGYMVDVANHGIEALDKLKRRQGGTPGLGLKAGSSRSGRSNMNPLPIAINLVLMDIEMPIQDGLTCTRTIRELEAEGEIFCASGGRIPIIAVTANARPEQVMEAKQAGCDDVMVKPYRIPELIEKMQVVVRRMGGLSPNSPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5Z3</accession>
    <name>S0E5Z3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431217.1">
        <property type="nucleotide sequence ID" value="XM_023578401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5Z3"/>
    <dbReference type="STRING" id="1279085.S0E5Z3"/>
    <dbReference type="GeneID" id="35407825"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14374"/>
    <dbReference type="HOGENOM" id="CLU_027514_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="523" mass="59454" checksum="51CA29DA5475786E" modified="2013-09-18" version="1">MSSSNNQACEALNGKQQRQYQCLCILLQAVNETCKHRSDIRYSSGKSRGYALLTDFQKAICKIAQILDNEKGGDSATALIVAKGLRGPDYVFASNLKKAPELERAKSFLSDLLEYVGSNPDELAPKALQKQVLDRILEFNFLRFDAYLNGLGTALQSCIDNCERSQEPSRSSDMAQLQAIKQKSLFPRDMTSSTNSKNKCKRPAPPPSSPTFAKTLGTKRDLEIVFRDCEDLIKAIHNSQNTGIDKVLHKYIGTTEPEISYQWSQLRHHLGRLHSFRQASEAIIDASTKWPLLFKNFTVNYIPSSRPRKFTRIHGLNASPTDIIKAAFPDQDLSYYEDDIAELRTYGLDEQIQKQELKFPSKSLVHCEANLHSHLITAGKTRPCDFWNDVMFIATSKPPCRLCYYYFQDGDNDFQVQSSHMNLYPRWRLPDIVDSNDEASIGHREELIEDMFEHMQDSILNVLQEKFPQWKRNDSRTDSRGCTDIREGADSRTPIGGHYVPPSVMDDDDYVTEIHTDTFGVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0E717</accession>
    <name>S0E717_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_07093</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430398.1">
        <property type="nucleotide sequence ID" value="XM_023577307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E717"/>
    <dbReference type="STRING" id="1279085.S0E717"/>
    <dbReference type="GeneID" id="35400570"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07093"/>
    <dbReference type="HOGENOM" id="CLU_012062_37_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8 11" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT68318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="372" mass="40350" checksum="FBA0B329B590A8BD" modified="2013-09-18" version="1">MATEGDSPARPRVFFDISLGGKPVGRITMELYADLVPKTAENFRALCTGEKGIGKSGKTLHYKGSIFHRVIKQFMIQGGDFTAGDGTGGESIYGNKFDDEAFPMKHEKPFLLSMANAGPNTNGSQFFITTVPTPHLDGKHVVFGEVLNGKSVVRQIENLTTQSGDRPAKEALIADCGELKGDAAVAADVKQPDALGDPYEDFPEDCTDTLDAVAIVKIATACKEYGNTAFKSGNYSLGLDKYQKGLRYINEDPDLENQPQSIKDDLKALRFSLNNNSALLNIKLEAWDDAARSASAALDVEGVKDADRAKAFYRRGLANIRLKDEEAALRDLNEANTLAPNDSAITRELNAVRTKAAARAAKEKAAYKKFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7B8</accession>
    <name>S0E7B8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to Vault poly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431727.1">
        <property type="nucleotide sequence ID" value="XM_023578771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7B8"/>
    <dbReference type="STRING" id="1279085.S0E7B8"/>
    <dbReference type="GeneID" id="35399028"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05549"/>
    <dbReference type="HOGENOM" id="CLU_003826_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="291"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1028" mass="110832" checksum="735F411B230A7BDB" modified="2013-09-18" version="1">MSLFGGSRIGSRRVTPPCGCYIFIQDAPRYLPQVQIKAHTTILATTSRTNLTQTFVNPSGEAIDELRYVFPLYDGVSVVAFTCTVGSRVIKGVVKERQKAQQVYNEAKAKGQTAGLFKQSLEAADTFTTTIGNVPAGEMVQVDITYLGELKHDAQVDGLRFTIPTQIVPRYGDSQSLPSSNVIQEQGISFTIDAEMPDGSAIKSIQSPSHPLSVEIGTTSTTKSQDPSLQRASATLQQGTTHLEQDFVVQVVATKLGEPSAILETHPTIPNQRAIMTTLVPRFKLPADKPEIVFICDRSGSMGGQIPGLKTALQIFLKSLPVGVKFNICSFGSHFSFLWDRSQSYSQETLDKAVQHIETFDSDYGGTEMYQPFEATFKKRYKDMNLEVFLLTDGEIWDQDRLFQLINKEVADSKGAARVFSLGIGAGASTSLIEGIARAGNGFAQTVADDEKMDKKVVRMLRGALFPHISDYSLEIKYDKGDSSSEDDFELVEKVVDALKIDTVHDEKKTKEVEAPKKPISLFDASANDDDDTEMADAPGVDNKFDHLPDVSSPRYLQTPGTIPPLFPFNRTTVYVLLSEDTPSQQPKSVILRGTSSHGPLELEIPITVVAEKDAVIHQLAARKEVKELEEGRGWLKYAKDSDGKLLGEKYDGHFSDMVEREAVRLGVKYQVGGKWCSFIAVEDNGNEVEQGEAQEAVPDEPSRRAMPQMMTASFGAASSGKPFLSFLSRSRKSTQPDTRSAGFGSSGSVAFGAAPAASPYDNFSSAGRGGGLFGSSTSSSTGGGLFGNSNAQARSFAPGSSAPPGSLFGAAPQRSFGTAETLFGSASIPPPPPPAAPTVQAAALAPPAAAVDEDLIDEYRKEMDEAAAMPLDFSIEGEESDEDMGFALMDDGPPAPAPAAASSLFSMPASSIAAAPKKKSIGDMEPLQALTSLQTFAGSWSWSADLERVLGVTSEEASKLALPASVKDHSEKDDVLATACAVLFFKKKLQEEMDTWEMLVEKAEGWLEDKIGEDEVSELLSVLEKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E853</accession>
    <name>S0E853_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433110.1">
        <property type="nucleotide sequence ID" value="XM_023580311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E853"/>
    <dbReference type="GeneID" id="35402407"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08933"/>
    <dbReference type="HOGENOM" id="CLU_019656_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="762" mass="84034" checksum="44ED262BA348CE62" modified="2013-09-18" version="1">MGFFSNIFARKNSNRASLKGQAYNSTVASIPPIQGNLPRRHVIRVPLTAPGTYPVAGNGPNVLDQLQRAARKRSQAQLSTLSQDPAAPPPMVPRFRGPSPSRPTTAPNQANSLSSRPLSLSRSIRSSNSAWSVPERPTRGRERPPPVPSIPTHHRRESSTDSAHDKRNSFIDILDAQGEFRPSNFRSRVAASGAREYGEDVAERNIGENGVNLNSAAAQAFYRLSGGRELQSFEYEEEEDDAAPAPGVPHGDLGTIREAWSRPSSSSAWRSFSGSIGNDLLRSGKSNRRESQSNLNPGTLSMRDRRRSFNAFASPSETEPQPRKPRPMSLHPSLSSGLTYETSSSPPPVQRSRPKTSEGRSRGRSFGRAEIDTVDEAFDEAAPCPIIPAQFRPDKRASVYLEPNYRYERNDVHHPRPESYHGGSTLSSYPRSELSQPSRPSSSSSIDKPFPRSRTMASVALRNQRLDDINEHIPVRTSSLNVNSQASITPTTQSSGFSSIQYPVGHHTPSTSIDASLPPSIKMRPEHEHTQHNSPGDDYSAETLVPSRMDIEQHLGHPMTADHDMDLYLSDASEDSIDSFVAWKEKRRDGEGLLMKDNYGMSGDGLPGIYEPLPILKAPTSPPPIPIIPSAPVSKRPKTPKSPKSPQRPRTRSNKSTPRRARQSRSRTTTPRRTRQVSTSEDPDSDSFWESDAPVAPGFVSLADLGIDLHEIGWDQYGLTEADDAKVDIQTAIKLRKAMEMRKKQQQQQRVDDEGCAADVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8G1</accession>
    <name>S0E8G1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_08780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433250.1">
        <property type="nucleotide sequence ID" value="XM_023580480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8G1"/>
    <dbReference type="STRING" id="1279085.S0E8G1"/>
    <dbReference type="GeneID" id="35402256"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08780"/>
    <dbReference type="HOGENOM" id="CLU_005595_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="302"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT71171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="783" mass="87557" checksum="5DE625773ACED467" modified="2013-09-18" version="1">MLHEILLSLSGHPSPLLRTDATQPHALSGVSPAERQLLASAAHLSDVHINLISYTAQVANSHPSTICRAVATAIDSIHLAAFQRKVLDVEASILQDDPDLVGAYNIVPLTAVIGEFKDWTRRMEWLWEMVQFMLAKNKKGETCHGAQLMDRLRLELQSGYRDVQNTAMSLVTVAETAWLKQVSAWILYGRLPSFGGDDFFVQKVEESENEYISRSSLLPAFVTPATASSMLFIGKSLNHIRVKSSVDSGLRGLDHLSSKLQELSSLSFPIKSTSFSRAIIAVRISLSENTLQKLLPLAKVTEMLQLLRDFFLLGRGEFAMQLTHEADEKIRSRWRRADNLAYEKGDGLKNVTVKEGEVAAVLARTWAVLASMQGQHAEEDEQLELARDLLRLNLTKSKATPNFGSGSGLSRDAVSLLSESPFRNLLFSVPSLLSIQIPPPLDMVLSPSDIQIYSCINAYLLSMRRAHIRLTDLWKITSLRRQYPTAKGGREHIILLRKRWTSRSSSMRSSWTTASAAIFFLAETEAYLQTEIVAGLWEGFHEWLTANDPKHGQSRAPTPTKLRDESGGADKDEEEDDDLWLGNENDKPTGQDDTPKARDSTPPQDPQTLSTAHRLYLRTLIHRLLLTQPTFTQPLYNLLIHIDHLVAHLHRLHAIYTSIDLETDAGVVDAFVDLESEERDVKRRLHDIESRVRSGIEDVVAALRALESDPIFTAEWEGDTAPATATEEDEDDQRDGRDRDTDDAEERGGFTAARVGGINRLLMKLDFGTWFGRPDGHDDVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8M6</accession>
    <name>S0E8M6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to MAK11 protein (Maintenance of killer toxin-encoding satellite M1 dsRNA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433308.1">
        <property type="nucleotide sequence ID" value="XM_023580549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8M6"/>
    <dbReference type="STRING" id="1279085.S0E8M6"/>
    <dbReference type="GeneID" id="35402193"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08717"/>
    <dbReference type="HOGENOM" id="CLU_030368_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="488" mass="52751" checksum="F88DA83F95145826" modified="2013-09-18" version="1">MAKRKRQAIAQNEPASEPSIKKKAKGTQVLKEKPVKAKTSALKKSTTTTSNAPETIQIVVGSYDRILHGLTVTVGGKEKAEFADTFLFNAHTSAIRCVAASPISAPVPGQTQKVMLASGSTDERVNVYNLSAHPPSRKNQEILAKVAPRPILENPKNREVGTLLHHSSTVTSLCFPTRSKLLSSSEDSTIAVTRTRDWSLLSNIKAPIPKPQGRPSGDTAPFGGTPSGVNDFAIHPSMKLMISVSKGERSMRLWNLVTGKKAGVLNFSKDMLQEAGEGKHSTGEGRRVVWGSVDGADEFAVGFDRDIVAFGMDSVPKCRIMGSIRTKVHQFFYVALDKEGDATLLAVATEDGRILFFSTKESDLTQPESEDKKLPTAKLMGQIGGKAGGVEGRIKDFVVVPSAEDASTLYVAGGSSDGRVRVWRVGVPELQGSDKAEEGKGELLGTYETQNRITCMTAFMMIPRPEGVEESEDELEDEEEEESDSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E997</accession>
    <name>S0E997_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to host-specific AK-toxin Akt2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432426.1">
        <property type="nucleotide sequence ID" value="XM_023579623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E997"/>
    <dbReference type="STRING" id="1279085.S0E997"/>
    <dbReference type="GeneID" id="35399789"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06312"/>
    <dbReference type="HOGENOM" id="CLU_036837_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="83"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="419" mass="47343" checksum="5C2A4479907EE819" modified="2013-09-18" version="1">MTSFPFTIQEHTIEASHIREYARATAHSQDEKLYLHVKQYTPKDNQNPQKGDVTIVGGHANGFPKELYEPLWEEFYHESKRRGIRIRSIWIADTAWQGKSGLINQDALGNDPSWLDYARDILHMINTFRPPPPIMAMGHSFGANALTNVALLHPRVFTSLVLLDPVISHFASTPGARSAGPAAASMHRREVWPSRDEAVASFGRSPFYKSWDPRVLQRWIDFGIRDVPGEQSVTLTTTKHQEIFTFLRPSWLAYDAEGKDVIHPEHTPDLDASLNRRWSTYPVYRPEGPNTVERLPNVRPSVLYVFGGKSDVSPPELIDEKMALTGTGIGGSGGEAKGRVKKVVGEKNGHLIPMEDPRLCASAAADWIKAELERWWADERQFEEWAKKSKEEKTTVSEEFQKHIGKPARRVKPSPKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9J1</accession>
    <name>S0E9J1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431218.1">
        <property type="nucleotide sequence ID" value="XM_023578402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9J1"/>
    <dbReference type="GeneID" id="35407824"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14373"/>
    <dbReference type="HOGENOM" id="CLU_2277547_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="104" mass="10899" checksum="516CA3139D00DA73" modified="2013-09-18" version="1">MSSGEQFVTSSPPIVYPTISMAGVNEDSENTHLATSNFDGSDGDIELTHDETETLRRIGNIIGRGSLANGFMPALSGTSYSTEAPIEEQSVVSPSVSGGYISAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9L3</accession>
    <name>S0E9L3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432531.1">
        <property type="nucleotide sequence ID" value="XM_023579751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9L3"/>
    <dbReference type="GeneID" id="35399904"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06427"/>
    <dbReference type="HOGENOM" id="CLU_030288_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="162"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="366" mass="42197" checksum="FCD90EFC4B19AED2" modified="2013-09-18" version="1">MGLLASNNHHQLHLSHLEHRVPMPRSLSAVSSLEIRDLNRDQIRFYHPGYLKPLNLLFCLPRVDYNTTEGAFGVHYLTALTACQIIANNAFEKGYLARDERGKDRVSDDETILLQRDYWFFVEGDDRYAIVPSFRDWQFPHDRLPEWWSVPTSRTSLYAKRCAVTNTSYAFTWAHLIPREEQSWFSKNGMGLYGGGSHTIDDPHNILPLKADLYVCFDQSVFALIPKQSGQANGVEANSQYVLHVLDGREAEFTALYQNRPVETLVEGSREFLFARFAWSIFSFLKPFLSSGVGRRVVRFRLRASDDDAEEEHLISEMQNVFMDSRKLESLYGGGNRRKIVSLEDSYVDVEDEWDDEHPGRTEMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAD6</accession>
    <name>S0EAD6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to protein TOL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432801.1">
        <property type="nucleotide sequence ID" value="XM_023578583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAD6"/>
    <dbReference type="STRING" id="1279085.S0EAD6"/>
    <dbReference type="GeneID" id="35398858"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05379"/>
    <dbReference type="HOGENOM" id="CLU_002639_2_12_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="245"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="693" mass="79256" checksum="718956566BCB7998" modified="2013-09-18" version="1">MAEEKPRPHVKILQSSSIRLPEFKPYQPNPALSHTPEFQRHTCKDCKRLILELLEHPAGSSSGGYSNSESHRDGLLSSLVHSSASCRVCAVIVNQIMSDRADVQHEFTHYQLALKAKKNSFCVRLTNDSEAADTTTRRNIYGEFALYRSELPKEFSWLDFGIVYTPTRNDLSVSCQPYLASRNYPWREKAIDKIKGWIDACETKHGHCPGRQSTALPERVLKIANDSVSLYISQKGDVQTEDQRYVALSYRWGNDLPVKLTKDTMGDFIKGHPISKLPETLQDAVRISRNLGFKFIWIDALCIVQDDENDWVEQSALMADIYQRSSLNLCAADSAGCGSGMVEMVAPHLIEIAAATTQSTDTDVGFFPGGWVFQEGLCSPRGLYVSRRHGLWWDCGTMIDMIDSRESISTGDFDHAFNPRTERRSFLSLTKNANHRSMAVRDFSFTWYDWMELYTSRYLTRETDRLPAVAGMASYVASLSGMKYKAGLWEEDIICGLMWRRGSSGHAKRVPGGAPTWSWASITGPVYYDEFFTMRVNHRGKIDHCAELDLDIMDTTIEEERPGTFGNVRRGEIKASGVMKHAAMMLLREQWNTKWEFDIQPKEPKAEVLEHCQVLRLAKAYRDKEGTPPVVYFLIIRETGRRENEYQRVGQGCIMLKYDQHPNRWELFRIYRDKKPDYGFLEEEIWGGLRKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAQ5</accession>
    <name>S0EAQ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to aldehyde reductase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434069.1">
        <property type="nucleotide sequence ID" value="XM_023581359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAQ5"/>
    <dbReference type="STRING" id="1279085.S0EAQ5"/>
    <dbReference type="GeneID" id="35407469"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14015"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="314" mass="34496" checksum="609DE7EA7A5C4E4E" modified="2013-09-18" version="1">MSPILNPSFTIPKGSTILVTGVNGFIGSHVANEFLQRGYQVRGTARDATKAAWIKDLFHQQYSKDNFSLWSIADLSSPHAFDKAIRGVAAVVHVASPLGLNSGTGTMIPDAIASALNALKAANDEPSVKRFVYTSSSTAAVFPEAEVPVIVDSNTWNDKALVILQNSASAPEWYVAYAASKVEAERAVWGFYHNDMTRRSDLVVNTVLPSTNFGKSLDWKHQGYPSTSGFIRTLWSGTALESLTNASPQYFIDVQDDAKLHVAATLLPDVQGERIFPWAETWNLDQILAILRAQNPDRTFVKDFQAMRYLADIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAR6</accession>
    <name>S0EAR6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to HOL1 protein (Member of major facilitator superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_14027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434057.1">
        <property type="nucleotide sequence ID" value="XM_023581346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAR6"/>
    <dbReference type="STRING" id="1279085.S0EAR6"/>
    <dbReference type="GeneID" id="35407481"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14027"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT71979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="473" mass="51776" checksum="3D1F068773A6DFD2" modified="2013-09-18" version="1">MGQVLGASIPPMLVPLVEDMHVSSTKISQLASWGSLCIGLGNIWALPTVAYIGSRYTILIGLAIFTAGFFWQAKAQSYESLLAARVIGGLGGGVVEALGPVVVVLLFPREYIARAMSVYSWALGGGSVFGPLITGYAVDNLGSWRYPNYIFGGICALNLFTMILMFPEPLTNIRVPGDPEPSDIVIESAGEEQVGEPKEPMEEVGNAQQYETRPASVTTFEPCKPGALWFRRSFFLTLKHNQPPPNFFYLVVEPFKILVSPAVIITVLLFGISIAGTIATSIIVSITFSQPPWLWTSGQVGLYNVAPLLGLIAGMPFGGAGADWLAERHLRRHGEFKPESVLPILLPFAIATPIATTLIGVGFQRGWHWAVVGLFWAILNANLTGGCNIMISYCTESYPKKAIQIGVVVNIIKNAIGFGVSYSTLDWWMKDKYFMFLAIAMIIFLLFIATIPLWISGPRITRKTKTWVRYEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAV9</accession>
    <name>S0EAV9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_13986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434097.1">
        <property type="nucleotide sequence ID" value="XM_023581391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAV9"/>
    <dbReference type="STRING" id="1279085.S0EAV9"/>
    <dbReference type="GeneID" id="35407440"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13986"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_10_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT72019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="520" mass="56095" checksum="F13F0FE9444B06FA" modified="2013-09-18" version="1">MPSTSIYQSVIYPGNHEKLDKPKDTQNFIDNKLVSSKTSSWIEVHDPATNNVITRVPESTNDELQEAVKSAKAAFPGWKRTSIIKRQQIMFKLTHLIREHMDNLATSIVTEQGKTFADAKGDVLRGLQVCETACGITTQLGGEVLEVAKDMETRSYRNPLGVVAAICPFNFPAMIPLWSLPVATVTGNCIIVKPSERDPGAAMMIAELCREAGFPPGVVNVVHGSKDTVNFLLDEPEIQAISFVGSNKAGEYIYQRGSANGKRVQANLGAKNHALLSPDANKDHALDSIAGAAFGAAGQRCMALSVLVTLGDAKQWLPDLVAKAKNHIAGSGFDSKSDFGPLITPQSRDRCNALITSAEKEGAKILLDGRGYKPDGFPDGNWVGPTVISGVRPDMECYKEEIFGPVLLCMEEETLKDGIDLINSNAWGNGAVIFTDSGAKASLFQQEIDAGQVGINVPIPVPLPMFSFTGNKRSVAGTGLANFYGKDGLRFYTQWKTVTSLWRADEASTGEKLTSMPTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBF8</accession>
    <name>S0EBF8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to 6-HYDROXY-D-NICOTINE OXIDASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_13763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434307.1">
        <property type="nucleotide sequence ID" value="XM_023581640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBF8"/>
    <dbReference type="STRING" id="1279085.S0EBF8"/>
    <dbReference type="GeneID" id="35407217"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13763"/>
    <dbReference type="HOGENOM" id="CLU_018354_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="45"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT72229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="484" mass="52960" checksum="7F201A930E494806" modified="2013-09-18" version="1">MTTLTPQPSIPQAERLIAAGLEARILTPTDAEFSARQESYWSNSAKIKPACIVQPRTPEEVASVVKALVSAGQMFAVRSGGHTNWAGSNNIEGGVTIDLVHLNHVSFDAATDTADIGPGCRWREVYAELSKHGRAVAGGREGNVGVAGLLLGGGNAFFTARQGFGCDNVVSYQVVLANGDIITADEKNNTDLYRVLKGGSNNFGIVTRFTMKAIKSDKVWGGMTFFPKQVIPGAIEALSSFTDNVPNDIHSNLVTIFTHMPDFKDVVIATLYANMEGIEKPPAYEKWLALPEIMSTVKNTTLTEMAFEYNIPANFYDTWFTCCFKNDTRIISKASELHDKLVEELKAFIPDGNFITQCLFQPLPTLFGQRGIEAGGNIMGMDRHKTNGILFLAVVMAQTAEQEAFARPKVQAWIKDVQEFAATIEGGNLEWTYLNYADKSQDPLGSYGAENIRKMKDAAAKYDPEQVFQKLVPGGFKISDVKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECF9</accession>
    <name>S0ECF9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">FFUJ_08411</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433586.1">
        <property type="nucleotide sequence ID" value="XM_023580891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECF9"/>
    <dbReference type="STRING" id="1279085.S0ECF9"/>
    <dbReference type="GeneID" id="35401887"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08411"/>
    <dbReference type="HOGENOM" id="CLU_003041_30_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098562">
        <property type="term" value="C:cytoplasmic side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036267">
        <property type="term" value="P:invasive filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010603">
        <property type="term" value="P:regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000749">
        <property type="term" value="P:response to pheromone triggering conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="80"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="260"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="429"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="437"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCT71507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="523" mass="58476" checksum="810A024CAF1846E1" modified="2013-09-18" version="1">MADQLADKLKSTQLSDGAPAAGDEWKKNLNLPAKDNRQQTEDVTNTKGLEFENFALKRDLLMGIFEAGFEKPSPIQEEAIPVALTGRDILARAKNGTGKTAAFVIPTLERINPKVSKIQCLILVPTRELAMQTSQVCKTLGKHLGINVMVTTGGTGLRDDIIRLQDPVHIVVGTPGRILDLAGKNVADLSECPMFIMDEADKLLSIEFTPVIEQLLQFHPKDRQVMLFSATFPLSVKDFSDKNMVSPYEINLMDELTLRGITQYYAFVEEKQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCFYSHAKMQQHARNRVFHDFRNGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRYGHLGLAINLINWDDRFNLYNIERDLGTEIQPIPASIDKSLYVYENPESIPRPISNMQRGQLPAAQGQQQPQTQQPQQYQQPQQMQQAGLPQQGQGNWQSQNPQHGNPHYNNGGRGRGRGRGYRGRGGQGAGGRGRGPPRDAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECP3</accession>
    <name>S0ECP3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434799.1">
        <property type="nucleotide sequence ID" value="XM_023582241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECP3"/>
    <dbReference type="STRING" id="1279085.S0ECP3"/>
    <dbReference type="GeneID" id="35406070"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12614"/>
    <dbReference type="HOGENOM" id="CLU_007091_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT72721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="736" mass="82020" checksum="DD85F7F0E1D5D7ED" modified="2013-09-18" version="1">MEPVRRRRRPAVSCNLCRKRKMRCNRGSPCSNCMRARKGDCVYENPPPAERSTASQDHIAEIGGDFNAFFSLPTPEDLVASANSALPGVSTAAASSSTGAPTPVSQSSVQELDMLRSRVRQLESQLSSATATPLQSHLSTPASTLETSTSRLGGTFHLHSQRQHAGALATPRAISHKSRFFGQSHFVCGLPLLRDIIEAIDQYASETSGLVIGVQKCKTMAKRIKALRAPAWPTPLTTELASKAVCDSLIECYLEGIEKVYRVLHVPTFRNKYDALWTSDVESDRDFVAQLKLVLALGATTYDGNFSLRASAVQWIYEVQTWISEPEFKSRLGIQFLQTNILLVLAREMVSVGGESPWIACGSLLRTAVSMGLHRDPALLSKTTTMACEMRRRLWNTILELCLQSSLSSGGPPMITEEEFDTEPPGNFDDDEIMVNGATSRPNSVFTQVSTARVLRLTFGTRLKVVKLLNNLKSGDSYQETLRLDAELKASYKEANRFLKDCKRGQNSATEFELSVGDFIVRRYFCALHFPYYGLSLQEPSYAFSRKMTVESAFRMWSTIFSDNANMVTSPDKRQFARLVTCSSGFFRLSAWQSSILLVLELRSTVQEDDSFSLAPVRPDLLKVMEDSKSWNLRTIEAGETNIKGYLMLSILRAQIMGIMQHLSESEIVEFIIKAGEEAMQDALVVFESFLAQLQPDGTEIQDLQEIDLGFMNDWDSLMVDDFLDDGVSDPLTWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDG2</accession>
    <name>S0EDG2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_08415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433956.1">
        <property type="nucleotide sequence ID" value="XM_023580887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDG2"/>
    <dbReference type="STRING" id="1279085.S0EDG2"/>
    <dbReference type="GeneID" id="35401891"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08415"/>
    <dbReference type="HOGENOM" id="CLU_024893_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495855" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="36"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT71877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="280" mass="29622" checksum="2A42BAE37048E929" modified="2013-09-18" version="1">MKTSTLMTMVLAAATNFMVHAATVSNDPVVEPVLNQMTSQGCWKSNGNLTVGYEGVKTTSGWCWDICKKKSSKVFSVQASKCYCGDVYPKEGDQVDDDKCNWPCPGYGKAACGALKNYWSVYNSGEDLAPDNYVPEETTTSAAPSSTKAAETTAAEESSPATGTQDAAATSEAASDDKKDGPNVAAIAAGVVVGVVVIAAIGGGAIFFVRRRRNAEIEEEHRRNAAVNAFINGSKPPGSSGSISMTDSRLDPVMAHRRLSDGSIADNQDYSRRILRVTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF78</accession>
    <name>S0EF78_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435507.1">
        <property type="nucleotide sequence ID" value="XM_023568281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF78"/>
    <dbReference type="GeneID" id="35403246"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09779"/>
    <dbReference type="HOGENOM" id="CLU_2740209_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="71" mass="7611" checksum="A9F9A13352AD3AE7" modified="2013-09-18" version="1">MTARDDSKGRSSVDDKAKCDEDDDLIGREKPAKLGTEIGLESRPGGLTQSGNPIPMPNAFPTDPTQHFNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF88</accession>
    <name>S0EF88_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to alcohol dehydrogenase homolog Bli-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434595.1">
        <property type="nucleotide sequence ID" value="XM_023581995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF88"/>
    <dbReference type="STRING" id="1279085.S0EF88"/>
    <dbReference type="GeneID" id="35405850"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12394"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF154">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_2G04560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="297" mass="32279" checksum="192E075E936F0086" modified="2013-09-18" version="1">MTSFKGFNPETDIPSLTGKVILITGGTSGLGRSAILTLASHNPSHIYFTGRSSASASSLISAISPVPATFLECDLTSIASMRSVAKKFTHDRLDVFIANAGVMAVDGLTQDGLELQFGVNHVGNTTLLMALLPIMQKTAEKSEVRFVSVTSLGYAGHPKQGIEFETLHSLQEHLPFGTWSRYGQSKLANIVLAKELERRCPAIKSVVVHPGVIATNLVTGLGFWKRMFVYVTNPSMMTVEQGGYNTAWASAGDVKRDETVAFYEPVGKANKGDDMCFSEELGKKLWQWTEEKIESVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGL5</accession>
    <name>S0EGL5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Related to putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_09845</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436234.1">
        <property type="nucleotide sequence ID" value="XM_023568207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGL5"/>
    <dbReference type="STRING" id="1279085.S0EGL5"/>
    <dbReference type="GeneID" id="35403312"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09845"/>
    <dbReference type="HOGENOM" id="CLU_002125_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="245"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="470"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="659"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1081"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1119"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT74156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1201" mass="133611" checksum="26C03A83F4FA4EB5" modified="2013-09-18" version="1">MSQFEQQQIPAAGQHYSAQNRVPNVRQFMDQLDQNKKARDAEIDEQLKQNKIHGETKDHKNDRAEALRKQKDIRTVRDPVTGKDVGIRDADIDYKEAVENPQLSIPNENLGKPATIATSSKQSGEEYRYAQDVTAPPDPVQEGATSDVPIRSEKTSVVFYKTPSVSYEPMFEILEQRSNVLCIGIFAAIVFIGKMFGGRLLGLIPLGFCVASGVFLWTKDLIRQGRDLEWSSEQERGETATANLIPESVEWMNTMLGVMWGLINPEMFAGVADTLEDVMAASVPGVIENVRVADISQGNNPIRILNMRALPDSHVQDIKDEQHRQNEKTTDPEELAANEQAGSFYNLEVAIAYHAKPSGADIASKARNMGMQLVFYLGIKGLFGVPLPIWVELQGLVATARIRLQLTPDPPFLKTLTFTLMGIPKVQAGCTPMIEKGVNILNLPLISNFVNWAIGAAASMYVAPKSLSLDLSKMLQGDDIKKETLALGVMFVRIHKATGLSKQDQRGSKGGGSDPYITISWSKFSKPQFCTRVIQDDLNPVFEESAGLLVTADLLKADEQLSVELWDSDRSSADDVVGKVELSIQKLIQHPGKMFPQVSKLRGVKADSEMPGELHWEVGFFGKTQFRKALRTDGRDLNLPKALADKPELQENKGAIDTKEEDAVIHTPPDPLWPSGILSIVVHQIVGLELENIKGSNGKRKGREYEPARPEAGEVKEEQAKSLPSSYCTILLNDDLVYKTRTKVVSSQPIFNAGTEKFIRDWRSAIVTVAVRDSRNRQHDPLIGVVPLKVTDILQTSSESTRWYPLDGGIGFGRIRISLLFRSVELRLPPPQLGWDIGTFEFVSDSITTTGYAPSNHAKIRFRTGGSSASIGKSSSSREADGMSFNISGADGNQRVRLPVRHRYSSPIFMEFYPSGKRNPDAYAVLWLLELVDGEETDFDIPVWKCNHSVRLSQNYITEENYKSVPDIEMEQVGRVRFRARFSAGTDSDHIKFASTNDDRETIEAWEACYAEGVRQQDVETEVPPVIQKLHEESLTHGRDVLAQADEKQKQKWLAKDGTDWSGAFGEDPSVLMRKKSNSESSEEYDDFDEDDSDPDLGIQDADTEPTDPSENGRPSVDTTGTNATSATNSSQASSNSKNPIKKIKSYRSDSRDMHRKHRGLMQWRPMRNVQFAKDEAKFAVRKVAKLGALDGRKPDVETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHG6</accession>
    <name>S0EHG6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Filamentous hemagglutinin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433907.1">
        <property type="nucleotide sequence ID" value="XM_023580232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHG6"/>
    <dbReference type="STRING" id="1279085.S0EHG6"/>
    <dbReference type="GeneID" id="35402479"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09005"/>
    <dbReference type="HOGENOM" id="CLU_092114_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485636" description="Filamentous hemagglutinin" evidence="2">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="24834" checksum="EB454F591CE30146" modified="2013-09-18" version="1">MKFQLTILTLAVLAFAKPQAPPDPAPAPPDPAPAPPDPAPSPPSTSEPPAPPPDPPAPAPPAPPPVPPPADPPAEPSQPPPPPPPPPSGPAPVPPPATPAPAPAPPPDPSPPPPPSSTAEPPPPEGPICECGYTYCSSVLKTMDNPWNEDQLSQAYCSTPNVKCDGESPASSIDNALFICLCDQPSQKIGNHLEFLCGCDKCLVVKPDYRGRCKTPPLAGSKGGKGDGKGNKVRGTNPLGFWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIA6</accession>
    <name>S0EIA6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">23S rRNA (-N6)-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435630.1">
        <property type="nucleotide sequence ID" value="XM_023568431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIA6"/>
    <dbReference type="SMR" id="S0EIA6"/>
    <dbReference type="STRING" id="1279085.S0EIA6"/>
    <dbReference type="GeneID" id="35403112"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09644"/>
    <dbReference type="HOGENOM" id="CLU_027534_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="54908" checksum="C4ED52FA5BD3832E" modified="2013-09-18" version="1">MGGKRKASQDLRGQSLPVDQTSTFEGPQEDATSRDNHYTELYSKAPDFQQLALQDADFGRLWKKHKNDFFNNPECVMQLTKSLLKLDFGLKLELPDDRLCPPVLNRHNYLMWLKGLLDSTSYEKQDRKIVGLDIGTGASCIYPLMGCIERDWEFIATGNSFTTPLARAPLIKADIDPKSLEYARKNVALNGLENRIKVVDQKPTDALIPLDDLNANNISFTMSNPPFYGSEEELLESARKKSRPPFTACTGAKVEMVTDGGEVAFVDRMLKESLVLQERVQWYTSMFGFLTSLIEFVDKLREHEIDNYAVTEFVQGSKTRRWAIAWSFGNMRPAQSIARGIKTAVSKNVLPEITEEKVVDIPLQEKIGDFVDCFRSELEKLDLITWEWDTERLEGIGRAAGRVWARAWRRRKQRGETEDQKVVDVKCEFAFKVSIRVGKDDVAVHCRWLEGHDPVTFESFRGYLKKTARSIIDIQSTENRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJV4</accession>
    <name>S0EJV4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to tol protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436220.1">
        <property type="nucleotide sequence ID" value="XM_023567913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJV4"/>
    <dbReference type="STRING" id="1279085.S0EJV4"/>
    <dbReference type="GeneID" id="35403577"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10110"/>
    <dbReference type="HOGENOM" id="CLU_002639_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="249"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="796" mass="90391" checksum="C0A8C69B11E5ECFF" modified="2013-09-18" version="1">MEENDSNTGLVLAETSKETHQDRLELLLAENPHKSFAVALFLVQLRLALQTDRTDSSSIDDVWIVQDPNERLLSRTGGSYWQSQDLCTQCQSIDLTQICSEGSLYGNGGNDVSLHTLETSTCPSCRFLTSQLHRRDKAVRSGDPIIIQLNRSILNGIDHVVIQHNNKLEYILQITDENLLQKPGRIGQYRQIDPRQVDYNMIRSWIAHCYRTHGKLCQMLTANPLRIPKFRLLDCKTLAVVELAEFVDYVALSYVWGSSSKLPGGDQGVLSKAVVRDAMHVTIQLGFRYIWVDQLCIDQTNAQDMSCQLGQMNTIYNQASITIIAAAGESSSYGLPGVGQRSRTIPNNFTLNGTTWRYKPMSFKSHVGASKWSTRGWTYQEAVFSRRCVIFADDQVFYQCGCMTCAEELIQDFAICERTVFPIFERILYKDSDIGTYLPRSWRFMTNLEAYSKRELTYDSDVLRAMEGVFGFYAQLEPSVEQYWGLPLRWAGCQLSNLDEKNVYHVAKSKHNDVMGAILWAMLWEPAWSEYHILKTGFVRRDGFPTWSWSGWKAGVRWNFLENVEHLEKSFTAPLFVETTAGGLVELNDALARPLTSGQSYASLGLTYILRITTKVFDVPFIERAPYKPTTSWAKSDSFPARRKGQHWVTKEDHSFEGKWTHFVVQKNIETSERGLVWSLDLTHGGAATSSDLVPDIDTNVNPMTLRCIVISYDYGMIVQCSSGISKRVGLLRFEGEFFENGRINTDEYGHHDDSVKWPWTDSVQSKDLRDHFPGVERTASEELLACATPVAMAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJV6</accession>
    <name>S0EJV6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to 1-aminocyclopropane-1-carboxylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437364.1">
        <property type="nucleotide sequence ID" value="XM_023570222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJV6"/>
    <dbReference type="STRING" id="1279085.S0EJV6"/>
    <dbReference type="GeneID" id="35404797"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11335"/>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="70"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="449" mass="49934" checksum="6521B742D35B3BAC" modified="2013-09-18" version="1">MMLDFGPSHRALASFNQGLAWDLMEKVRQIPHYDPVAEPAGIIDLSGALNALMDDWMEEYYISLPPLHVKSIFNYGPLYGSDQLRSAAVGFFNRFFKPSSPVLPSHVLAGTGVTSLIDLIAWTICDEGDGVLYLTPNFYMLETDLTIRASVTAIPVSTSGLQYPDGESDIEQLVCAFEDAATDAEAKGIKCRVLFLCNPQNPTGRCYSPKTLYALAKWCARRGMHLVADEIYALSTFDHDENSEMQNFCSVLSIPSDGVLKDNVHCLYGMSKDFNMGGMRMGFLVTRNAEILNAATRATWFTWVTAFSDSFIARFLGHLELVESYRVLYQRRLGEQYATTVTALKSNGIPYQRAKAGLFVFVNLSKWLVYFKTDETPESGHATPELRLCSWLIDHGVFLNPGQFAGSEGPGHFRLVFTEVPDATVLAIIRMRKALQALEGNNPTGDRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKZ1</accession>
    <name>S0EKZ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to trichodiene oxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437547.1">
        <property type="nucleotide sequence ID" value="XM_023570434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKZ1"/>
    <dbReference type="STRING" id="1279085.S0EKZ1"/>
    <dbReference type="GeneID" id="35404987"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11525"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="520" mass="59711" checksum="8C0748AB7D030B23" modified="2013-09-18" version="1">MFHIFDNNSSIERTKLFQYAVIFFVSFKLITYLQRLFFHPLSKFPGPRICAASRLYEFYWDSYQHGRLWAKLPDLHRLYGPIVRIGPNEVHIEDSEYFDTIFGFRPLNKEAMTAKEFGINHALFGVEDYKTYVKKRAAFGNAFSRTKLSKIQDQINEEIQKGCTWVEDNSKDGSPVDLAFLFRAVPAEIITKYLFGQEYGFLQHVQTTKNLYDKRMDRLLGFSHLGRFIPKEIPLFLSLFRQLILRALGFNDPGSAFLDYFLLAQKLVQNVVAQHNHQNHNAESITQHTVFDDFLDSSLPQEEKEKGPLTQQAVAIWSGGWDTVGFVLTMAAYQLLKNPPVEQRLYQELKKAWKDPTESPEITTLESLPYLTAVVKETFRLSPGALCRLSRVNPSGIEQYGDWEIPPGTIISMSIPDVLSDKAIWGSDAAVFKPERWLSGGADLDRYLVTFSKGTRVCPGIELAWIETRLVIASLFRRYEMSITPEAGISDDDIMPYYEGFTPAVKNWISRLPVRAKPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELM9</accession>
    <name>S0ELM9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437767.1">
        <property type="nucleotide sequence ID" value="XM_023570692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELM9"/>
    <dbReference type="GeneID" id="35405218"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11757"/>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="68"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="235" mass="25905" checksum="D3F53FD846AB1C90" modified="2013-09-18" version="1">MAPLHLGALVYDYQAIDVLGPTDLLHSSSKPYLKTLSGYLKIEQDTISRAPEFVFHHIGITREAFVLQTSNITIVPTTTVDECPVLDVLLLGGPDPFNFELHPKYAEFIKKHVAAGKLVFTTCTGASVAAAAGVLDGKNATVNHGAIQPLRLKFPNVKWTDEKKWIIDGNIWTAGGAVAGMDMFAHWIKENFGMDIMVLAASMLDYEPRDVDGILNVIPKRYDENGKQLQTHVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM39</accession>
    <name>S0EM39_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437713.1">
        <property type="nucleotide sequence ID" value="XM_023570628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM39"/>
    <dbReference type="STRING" id="1279085.S0EM39"/>
    <dbReference type="GeneID" id="35405161"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11700"/>
    <dbReference type="HOGENOM" id="CLU_891452_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30938" checksum="5E4BC1B7EE4AC39C" modified="2013-09-18" version="1">MEMIKADSQLFSSLQELLPSILGRCVRHGCIDLVRYLLECERAPVESLSPLAVAANSSIPLVELLVAHGWDLNKAEADRSLKRGDKLIDLVCDDHQLVRWLVEHGARVTYGEVDLYELFPQPAPLLETCAARGSVATFRFLHSKGALLGHRTLHRAAGEAATFGADPFTCQEVHDEIVGDEARTRKERAEMLMFLVGGMKLDINSIDSTVPYRAYHWGTPLCYAAVKENGAHVVRWLLEKGAQPKVETAQNVADAEMLAKLTGCTENARILREWKEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMD0</accession>
    <name>S0EMD0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438027.1">
        <property type="nucleotide sequence ID" value="XM_023571002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMD0"/>
    <dbReference type="STRING" id="1279085.S0EMD0"/>
    <dbReference type="GeneID" id="35405496"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12036"/>
    <dbReference type="HOGENOM" id="CLU_014626_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="843" mass="94455" checksum="B3593DA36C60F82C" modified="2013-09-18" version="1">MDPTLEDLRPKSDDGKFLSHSYEERWSRLQPVIVELYTRRRGGDGRSATLDQVVEFMRTYYSFHAAATEYRRRFKDWGVTKRMVKEDKDAITSALARKKRPGASMSAVTTQHDGEYKPLVFKKLKRHLISRKACLRVAPGLLSSWKLPYVAFVASLPKNPEAPSPFGNLGATPNYLHVQSPETLTPGRATAGASPRMQLVYEKHKEHCTSLFLQGRLEQLLISLPREDRVVIFDYFHDYYIHSFALAKNWGREVPNSTQAFDLIPQTPITHSPWTPSAFLNLSSGPSSPEISNATNVSFPPTQLCNWSIHSYYGNGNSMAVTTSPDSKTSTDIQPSSFVVSLHQSMVLSNFTTIPKSDLPLAHDLITRSLEEHPATLQLEAWKLAIMAGNRELLDQLCEENGFDPPEGIEALHPFHLAAAYLDGGNQCCGVFTVFFQIVSPTFAFYHNIDDHGHTILDALIVTVLRSHTNIQPDDVSYGFHSPTVFPGEESDVCGRWDSETPTVRELFRQGYARIPTKWKHPFCHTAVQAVCHSLVAIFASPASPNIHTQSGLFVRRCTTCGLELKLRPLHTIVVVAFYLAQLGMPGETLFGALAMMTCLIALGADVSTKADISVEEILRSSDAGECRHKMLSPLELIKAIPGGVIEAWSESCRIGWGCLTETLVLVVLEREQERSSRSQGSMGPLGHKWPGTLASSLSDSLADESCWVMFQEECHDNWLKLPCSGQRIGLLWASIQTEVLTYRRIREGDSWISENFSMKALKAWLEAEDTELSMPLVQKRMFKVHTRCGWFGKAMEFLCPTAEDVCRKHFMNMDIDSKTSYIEQPDLQGAFESLEQVEDGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMG7</accession>
    <name>S0EMG7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437160.1">
        <property type="nucleotide sequence ID" value="XM_023570033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMG7"/>
    <dbReference type="STRING" id="1279085.S0EMG7"/>
    <dbReference type="GeneID" id="35404629"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11165"/>
    <dbReference type="HOGENOM" id="CLU_052604_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01066">
        <property type="entry name" value="APP_MetAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050020">
        <property type="entry name" value="DddP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF043017">
        <property type="entry name" value="DimsulpropLyDddP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF8">
        <property type="entry name" value="CYTOPLASMIC PEPTIDASE PEPQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="229"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="456" mass="51128" checksum="51BB5584E805AD90" modified="2013-09-18" version="1">MKEKEEPVKPSSLCALPKISRHIDPTKPRTDTLKPDGSEDNNDRVDIGPTPLAFSEWEKLGLELPHLPRMRAYRLQRIREQLIARDLGGILLFDPLNIRYATDTTNMQLWTAHNPARACFVAAGGYLVLWDFHGCEHLSSHLPLINEVRAGASFFYFETGPRTNEHAQNFGAQVDELLRNHAGDNRRLAVDRIEAAGLRALEAKGIEVCDGQAVTEHARMIKGPDEIRAMRCAIASCEAALAEVRQAIHAGVTENDVWAALHAGNIRRGGEWIETRLLSSGPRTNPWYQECGPRVLHDGDLVALDTDLVGVYGMCVDMSRTWICGDVEPTAEQKRLYRIALEHINANAEMVKPGVKFSELTQNGHRLPESCRAQRYGVMFHGVGLCDEYPCIRYPEDFNSYGYEGELQEGMVLCVEAYVGEVDGKDGVKLENQLLVTNTGYELLTHYPFEESFLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENM4</accession>
    <name>S0ENM4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436301.1">
        <property type="nucleotide sequence ID" value="XM_023569029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENM4"/>
    <dbReference type="STRING" id="1279085.S0ENM4"/>
    <dbReference type="GeneID" id="35403731"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10266"/>
    <dbReference type="HOGENOM" id="CLU_071636_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02215">
        <property type="entry name" value="cupin_QDO_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053146">
        <property type="entry name" value="QDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="346" mass="38009" checksum="96955088FC43B193" modified="2013-09-18" version="1">MSIPVVNTPPDSRTNYILPQLAGERITFPGWKGVFRILASSKQTNGGLAVLAGGSVLSDPPGFHWHEEAHDVFLVIKGFLKVWAGDQCRILGPGDFAYVPPKVIHNPQWLGPHCESFNLVAPGDWVDFFRFSGLEFDGLVLPENSQRDEEKLMAMMVAAKDKFDVHYAHDFKPAELSDWLETENKLGEPLQPYFLRSNTGPRWMAGGVLSRPFILASQNGERFAISSIESSSAYKASIFKSYIKFATVDHCLFVVEGKLKVELEGSSGQNVLHDGETVVISADQGFKLGFASPFVKIFSVANGRGIETLIQDAGKPFDGLVLPDAVEVLDSQKLARVAKEINATID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENX9</accession>
    <name>S0ENX9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to bifunctional 4-hydroxyphenylacetate degradation enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438030.1">
        <property type="nucleotide sequence ID" value="XM_023571008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENX9"/>
    <dbReference type="STRING" id="1279085.S0ENX9"/>
    <dbReference type="GeneID" id="35405501"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12041"/>
    <dbReference type="HOGENOM" id="CLU_436837_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="83"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="348"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT75984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="591" mass="63081" checksum="DCC7A28B6ABFFD58" modified="2013-09-18" version="1">MGSQSTSNIMQYAAYVHPTTGLPRVGHYDLANGTIQPLSFTSGTPVRNLYEVIAAGASQVIPDGDPLPANDVKLLAPISGRDIMAVGKNYMEHAKEFNSSGYDSSDKTDRPSHPVIFTKRATSIIAHGETILPHPEFSQTLDYEGEIGVIIGKTGYRVSEADAWDYVWGYTNINDMTARERQRDHKQFFIGKSPDTFCPMGPVAVSKNDLPSVLKVETHVNGEPRQSSTTEDLIFSIPTLIKTISEGQTLQPGDVIATGTPAGVGIGKNPPVFLQPGDEVSVSVTGLGTLSNRIGTAETVNPTVQRVSSESPFRINNLAKTLDAGVRLTKLNGKQLNYQRKGSGNHHIVFVHGLGGTQEYWTPLISKLSLSENNSLHLFDLEGHGLSPTHPLSKLSIESFAQDIRSIFDAANITSSSPATLFAHSLGCLAALNFTLSNPSLVGRLVLLGPPPSPLPDAASKGAYARAAVVRSSGMAHVVDGVVDAGTSAHSKQTNPIAIAAVRLSLLGQDPESYAKATWALAGATKELKVEQIQARTLIITGDEDKVSPASLCEKYASRIQDAQLVVLSNVGHWHVFEDVGGVAQAVAKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPW9</accession>
    <name>S0EPW9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437926.1">
        <property type="nucleotide sequence ID" value="XM_023570879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPW9"/>
    <dbReference type="GeneID" id="35405385"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11925"/>
    <dbReference type="HOGENOM" id="CLU_969931_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="287" mass="32704" checksum="8EE59259FC4096FC" modified="2013-09-18" version="1">MPGQCPPCLPARENVKDTCMDPQYIPGGDYTIAQINEGSLEFQVSEAWTLILRDAFSIYEGFRVDYEADIHGRRIDMEVCHMNNHRMLNFLGLVLKRYAYLNSTHPLDDAETELKSTWNLWASHRRVGFGERYVLARGLSFTNTTRKAAMLDSWRYMMACCKLIDSPRRWEGHAQCMGPQNLWVAKCDNYFERPSAEAGLDQFACKLAGYLGLEIPFHRRVSQALRVSPVIQNRKLFQHIGRVVYVTRAFKALPIPPSLDSPVDSGLIEIMVIPLVEAFIVGKESPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPZ2</accession>
    <name>S0EPZ2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438041.1">
        <property type="nucleotide sequence ID" value="XM_023571021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPZ2"/>
    <dbReference type="STRING" id="1279085.S0EPZ2"/>
    <dbReference type="GeneID" id="35405513"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12053"/>
    <dbReference type="HOGENOM" id="CLU_040088_4_0_1"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="289" mass="31685" checksum="2103512072738144" modified="2013-09-18" version="1">MDSWLEVQKQNRTLQILRSAAEGRYGVLAIICYNIEHLTALVRAAEAKRSPLILLLFPSTVKQFPTLGWAAAAAVKSATVPLSLHLDHAQDEAQIREIAATLPFDSIMVDMSHYDHDANLEKTKLLTRICHDHGIAVEAESGRINGGEEGIADTGSLEAMFTTPREVEDFLAAGIDLLAPSIGNIHGDYGPAGPQLDFDRLSSVNTQVNSRVIMALHGTNDFTPEIMQRCIQSGAVKLNINKLILESWNTYVREHAQEPLMQLMDGGMAVLQAEVERWMVICGSSGKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ00</accession>
    <name>S0EQ00_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438081.1">
        <property type="nucleotide sequence ID" value="XM_023571072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ00"/>
    <dbReference type="STRING" id="1279085.S0EQ00"/>
    <dbReference type="GeneID" id="35405559"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12099"/>
    <dbReference type="HOGENOM" id="CLU_001859_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT76035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="500" mass="57158" checksum="5A7270ED853552E7" modified="2013-09-18" version="1">MSKEASMFQAGDLVTSSGTTDDLTVQELPLPTDFRWGTATAAYQVEGGANQDGKGQSIWDTYTHLEPPRTNNGETGDVACDHYNRVPEDIELMKACGVDVYRFSLSWTRIIPLGGRNDPINEKGIAFYNDLIDRLLAHGIEPVVTLYHWDAPQTLYGRYKAFLNTEEFAADFCNYARLCFERFGDRVKKWITFNEPYIISIFGHVNGTLAPGHRAEDGFDTKNEPWRVGHTLIISHAVAVQLYAKEFKPAQQGEISIVLNSHFYEPYSDTQADMDAAQRRLEFYVGWFGDPIFLGEDYPVSMRNYLGDRIPHFSIEERNLLRATARLNTFYGMNHYSTKFARALPDLPSEDDWTGNIEEGAVNGAGQEIGPVSQFQWLRVAPNGFRKLLNWVWNRYHLPIIVTENGCPCPGEQDLKVAIDDQFRQRYFGLYLDAISRAVYDDGIPVKGYYVWTLMDNFEWSAGYQPKFGIVHVDFENGLTRTPKNSATYLRETFQRRRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ15</accession>
    <name>S0EQ15_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to adenine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_14260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438156.1">
        <property type="nucleotide sequence ID" value="XM_023571089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ15"/>
    <dbReference type="STRING" id="1279085.S0EQ15"/>
    <dbReference type="GeneID" id="35407712"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14260"/>
    <dbReference type="HOGENOM" id="CLU_003324_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF25">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="314"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT76110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1168" mass="127278" checksum="92A837EC313106AE" modified="2013-09-18" version="1">MATLDTLKQALRQTARATAPHATQPLSHVEYSAGFDVLFQGSESTTYQKFIVPQLSSLLRRLLKSRGYISLLEIGPGPKSIVGYLPYHIRRKVRRYVAFEPNDLFAIRLDDWLHHISGTETPLPCLERRPDIHQMPFTPENDNKNTRSSTGIGASEGEKFDVVIFCHSMYGMKPKRKFIERALKSLDDHSEPGIVAVFHRDGDLNLDGLVCHSTASFPTGVVRVATDDEKMDRFTSLIAGFTFAEAKMDEAIRGEWRKLCHALGRCEKAHPDHLLFSSPNVMATFTKQAITLPDLMAQMPLVDKGRRIKNQEARLHRPASIVRPKQIQHIQQCVNWALEQNVGLTVIGGSHSGQCLWPNVVAIDMGAFDQVHTVTTVTEGEGPNLDSTPLVIAEAGCNTGDIIRKTMAVGLTVPMGARPSVGSGLWLQGGVGHLTRLHGLACDAIVGAVMVSVASGQVLYVGRVPSKHRPAGAMKSEDESDILWALKGAGTNFGIIVSVVFEAHAARIYCVRNWSIPLKDHHEARLKLHEFDQCTKTFARHCSADAYLYSNNAQIHLGVTLIESATTKVASQSHTLIDSALGPEGSLETVDGVGLFETEMYVSGMHGGHGGGKTSSFKRCLFLKQIGAVGISDVLLAAIETRPSPLCYIHLLQGGGALSDVADDATAFGCRDWDFACVITAVWPRDQGGTEVALDAVKWVYDVARDLLPLSSGAYGADLGPDPRDTPLAAMAFGPNGPRLAWLKETLDPRKVLAYACPLPTPPTKQKLIILVTGESGAGKDHCADIWVSMFTRCAHKHCKARKASISDTTKREYAAATGADFGALLLDRAYKEQHRPELTAFFKEQMRQQPRLPEKHFLNVVSGAADTDVLVITGMRDEAPTATLSHLVPNCRLLDIHVTASEKTRQARRKCQVKENNLHDHDYKNGHRGSNGSDCKSNSTTLNYLHSLVFDNEATGDGVAGRFADKYLLPLLHKDLERLATMVVPVPDFPRPGIDFRHVLNIAQRQGGLALCTSLLQTQFKGDWGEVGAVACCEAGGFVYASALAQQVNVPMALIREAGKLPPPTFSVNKPSSHISGSEFNHLGGKKIEMSQDLIPRGASVVVIDDVLATGKTLYAVLQLLAEAGIGNENISIMVVAEFPVHHGRELLYYHGFGDISLQSLLVFDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHY4</accession>
    <name>S0DHY4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423995.1">
        <property type="nucleotide sequence ID" value="XM_023577040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHY4"/>
    <dbReference type="STRING" id="1279085.S0DHY4"/>
    <dbReference type="GeneID" id="35395073"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01588"/>
    <dbReference type="HOGENOM" id="CLU_860633_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="323" mass="35795" checksum="31B01BC799EE74C1" modified="2013-09-18" version="1">MARGNSSAALRPDQDGPKYDLTTLANPIRPVSGPHVPMFNLEQVYDIFNGTPWGNQQNDTVGEQNPTESRQNDKTAQSRASKQTKRKSLGHRAGSGVSKTSRLHKQPATQLKRSKNLQGKNPIDLVARGAIPTPSSPSDPAPYYEVARAPNFSRPIPDFDPALISNCPKPLSPSDMLDGEKYFLYQMATARHLAFNGVLGPYQIGHCLCDVHRATGNLVKFARACTAPNGERYWRHLMTNASIKAQDGSRMAGKPIALSNGALVWMTDEKGKVIAPEWTFNEPQFLPEFSDDQEMGQYPKQSQQETNPIHPGLKNTSKDPFWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI00</accession>
    <name>S0DI00_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pectin lyase</fullName>
            <ecNumber evidence="7">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_01825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="7"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423776.1">
        <property type="nucleotide sequence ID" value="XM_023574406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI00"/>
    <dbReference type="STRING" id="1279085.S0DI00"/>
    <dbReference type="GeneID" id="35395309"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01825"/>
    <dbReference type="HOGENOM" id="CLU_021980_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484956" description="pectin lyase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="10">
        <location>
            <begin position="94"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT61695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="375" mass="39368" checksum="54FEFC514657C57E" modified="2013-09-18" version="1">MPSLFKTLFAVAAAIPSVLGALPTRAEGFASSTTGGGSAGAVYPKTAAELVSYLGDSSARVIYLDRTINFIGTEGTASETGCAPWGTGSKCQTAINQNNWCGNYQPNAPKVNVKYDKAGILGIKVGSNKSLIGVGSKGVIRGKGLRIVGSKNVIIQNVHITELNPQYVWGGDAITLDNTDNVWIDHVTTSLIGRQHIVLGNNACNRVTISNSKIDGTTSWSASCNNYHYWGLYFAGSNDLVTFKNNYVYRVSGRGPKVAGNTLLHAVNNFFHDVPDHAFEIDSGSVLAEGNIFQNVKYPVDSKGYQGQLFGVPTSGSPCAASLGRNCQLNGFGSSGTLGGTNTGFLSNFKGKTIASASDYNSAKSVMTSAGFGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI99</accession>
    <name>S0DI99_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424160.1">
        <property type="nucleotide sequence ID" value="XM_023579105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI99"/>
    <dbReference type="STRING" id="1279085.S0DI99"/>
    <dbReference type="GeneID" id="35394888"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01403"/>
    <dbReference type="HOGENOM" id="CLU_019479_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="160"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="576" mass="62991" checksum="75B71B9454C81525" modified="2013-09-18" version="1">MADQINEKPEVEATAPGAQEVPAAEKPTEPSTIGNEAAKADGEANKEDTKTAEETKQAGNSEKLAEDKDAAEVPKENSKPTEEGADTEMKDATEAPAAGETKAENSAPSADGETATENAATESASAKAKNNRRKSTGGASRKSLSKKASKARLTHLDAKPGDHFLVKLKGFPAWPAIICDESMLPQALVDSRPVAAARPDGSYTEAYADGGKRVNDRTFPVMYLHTNEFGWVPNTGLTELTPEKARETITEKMRKDLKEAFSLAAEHNSIEHYKDVLKQFQDELLAKQQAAATPKKSKKGKAKAADEDVEMEDADDASEKSKSKKRKAEDDASTPQRPESVKKPKIKLNTSTPKAANGTPKAKEESAAKAKVKVKKSSDKKAETTKKAKMTPEERRHHKEKEVLYLRHKLQRGLLTRDQQPQESEMEHMSEYVTMLENLKDLEVSIIRATKINKVLKAILKLESIPREDDFHFKDRSKVLLDQWTQLLATENVTPAPDATNGVNGKSEAKADDKKDDSGKETTEEPKPEAAKTEEAKTEKPEETEEEKIAETPQASAPEEKKDETVAPPEPVEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIF1</accession>
    <name>S0DIF1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424051.1">
        <property type="nucleotide sequence ID" value="XM_023577728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIF1"/>
    <dbReference type="STRING" id="1279085.S0DIF1"/>
    <dbReference type="GeneID" id="35395011"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01526"/>
    <dbReference type="HOGENOM" id="CLU_052827_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF7">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G10800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="165"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="265" mass="28407" checksum="618FA395C23E08F2" modified="2013-09-18" version="1">MDVLQRKLANSLLVLRSPAVMRLEVSATAAAGGAFKRAAGMLLAGVGASTAGGFGTWYTMHSNGMGFHSDEESLRRFVANHEEAKMVEETINKHPLVAELRANPELTESRPHMKMPGSYRSRSLTGGALIGEGKMPVPPYAWMAPKGKQLVSIAYVGDDLCGHPGIVHGGFLATMLDEGLGRCSFGALPHNIAVTANLNVDYRKPTPAGSFLVLRAETYKVEGRKAWVRGHIELLAEPGEKPTIVAEAQALFISPKYAAMMPKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIQ1</accession>
    <name>S0DIQ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424107.1">
        <property type="nucleotide sequence ID" value="XM_023578428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIQ1"/>
    <dbReference type="STRING" id="1279085.S0DIQ1"/>
    <dbReference type="GeneID" id="35394948"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01463"/>
    <dbReference type="HOGENOM" id="CLU_137480_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF2">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="113" mass="12646" checksum="8828F24279B693BA" modified="2013-09-18" version="1">MARGETQQTKVHYKGSDDFIIFIDDVETYQKWKSDKSIPLAHFISSFKIFLTHNQGVQGSLDAASKAALENEFGTSVDDDVIKQILEKGDTQTVDFPERQGPKNDSKGPMISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ90</accession>
    <name>S0DJ90_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424630.1">
        <property type="nucleotide sequence ID" value="XM_023570008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJ90"/>
    <dbReference type="STRING" id="1279085.S0DJ90"/>
    <dbReference type="GeneID" id="35394377"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00892"/>
    <dbReference type="HOGENOM" id="CLU_018461_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF904">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="45"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="621" mass="68795" checksum="335A12BCED12AD65" modified="2013-09-18" version="1">MPEKSASVVSYAAGASLAAAALIYVFAPNFSIDHDATSSKKKSIVGLRNQANDCFINSVLQALAGLGELRIYLIRETHRRRIEDPAVYASLVQPEGKQIAQWKLQGLQEGLVTQGLKEMLDALNERPIYKKSISPFQFVKVLEAAFKQRISRQQQDAQEFLQIVAERLKDEYHCGQRARLHMRRRGLFPTQSTPSVENTLDSQDNGKDGDESSPEQQPTTNGDNDSAIEPSEETEIPQDNGQLPIEIEEGFPMEGKYESHLECQTCRYKTKPREETFCTITLAVPQVSGTTLNACFDGIFKTEYIDDFKCEMCRLMQTKADLEAEMAKSTSESFKAQAQESIDKLQHAIDTDPENPPDDVELGDIRFAPKRRIAKTTRMSIFPKILAIHLSRSIYDVGQITQKNSAKVVFPEQLPLGGLMDQKRYKLLGLVTHRGGHNSGHYEAFRRQNVAAPFSNPNTFQPSEAFSKTPTPIGTPIMGGRPTHSPAISTPDLLSGSSGDSTPSLESLPVPPRSVPSDLRGSVSLPAIGNQKDPETSSLRSVAASTKSALSKLTSPKQTNSSSSPPKSVTSNVAKRSRKRKSATDKWWRVNDEKVKEAKTSEVLGMQREVYLLFYELDKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJS0</accession>
    <name>S0DJS0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_00828</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424686.1">
        <property type="nucleotide sequence ID" value="XM_023570718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJS0"/>
    <dbReference type="STRING" id="1279085.S0DJS0"/>
    <dbReference type="GeneID" id="35394313"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00828"/>
    <dbReference type="HOGENOM" id="CLU_142427_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT62605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="97" mass="10835" checksum="9DC4930D9A314D2F" modified="2013-09-18" version="1">MGGQEKTYFEQQREALIGEIAMARHSFEHVLANINKLNRSLEAVTAVGNEFSSVEALWSQFENVMDKDGKAEGETDQADQTEHHEEEGDTTVKHEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK66</accession>
    <name>S0DK66_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_00660</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424837.1">
        <property type="nucleotide sequence ID" value="XM_023572585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK66"/>
    <dbReference type="STRING" id="1279085.S0DK66"/>
    <dbReference type="GeneID" id="35394145"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00660"/>
    <dbReference type="HOGENOM" id="CLU_012062_14_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000034">
        <property type="entry name" value="Peptidyl-prolyl isomerase CWC27 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="16">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="262"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="505"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT62756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="550" mass="60941" checksum="5DF6DB1D93C113F3" modified="2013-09-18" version="1">MSAIYNLEPQPTASVIIHTTRGELSVELFAKQTPLTCRNFLQLALDGYYDNTIFHRLVPGFILQGGDPTGTGNGGESIYDGGAFSGDLDPWPMDQRQGKNAGPTGINFKDEFHSRLKFNRRGLLGSANESRPDTNGSQFFFTLDRAEELNGKNTLFGRIAGDTIYNLAKMGDGEVDEATERPTYPVKIERVEILVNPFDDMKKRSRVATQAPSNKTAAATSKDKKKKRKGGKQLLSFGDEEGDDDMPVLKKKKFDTRIVMEDEEEDEITRKPAKPKAKKPTVTEKLPSVADEINDKVPRKPTLDQPSNETRRSPGSLTIREVKDQSPEPEAPKKTALERANEEMAALKASMRRTIHAEEPVKEKKKSALEAMIPETSIRGRKRRPGATNTSASEDAKTLGMLKAFQSRLERAPPEKGNEHTTTGVVREEGSTHAPDDEAELCDLHFIANCQSCTSWDKQEKDESDDEGWMSHSLSFAADKLGKDLSNRKKAEEELVVIDPREKARTLKDEKRAARDARQGNSGRAWDQARDAARNAKMAQAASLAGRGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK90</accession>
    <name>S0DK90_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423838.1">
        <property type="nucleotide sequence ID" value="XM_023575162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK90"/>
    <dbReference type="STRING" id="1279085.S0DK90"/>
    <dbReference type="GeneID" id="35395241"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01756"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000020">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001075">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000767">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="31"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="231"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT61757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="674" mass="74891" checksum="80AB175F68F8E7C0" modified="2013-09-18" version="1">MADLDLDAAFIPALHKPAALLPIAKHRESLLYVIEKYQVTIVIGQTGSGKTTQIPQFLERAGWCSGGKIIGVTQPRRVAATTVAVRVAEEVGCELGKEVGYSIRFEDVTSASTKIKFLTDGLLIREALVDPLLTRYSVIMVDEAHERSISTDVLLGLLKKIRRKRPELRIIISSATLQAKEFLEFFTRSSDDQPNKTDKKDDTGAIVSLEGRTYPIDILYLESPAENYVEKAIDVVFDIHTQEGEGDILVFLTGREEIDNAIQAVSERMLDLGSKHGPLMPLPLYAGLSTEQQMYVFDKLPEGTRKVVFSTNIAEASVTIDGIVFVVDSGFVKLRAYDPRTGIESLTATAVSKAAASQRAGRAGRTKPGKCFRLYTEQSYQSLPDANVPELQRSNLAPVILQLKALGIDNIVRFDFLSPPPSELMAKALELLYALGALDEYAKLTRPMGSRMAELAVEPMMAKTLLAAPSFGCLSEMLTIAAMTSLGGSVWFSHEGEKKKMETSRRKFAVDEGDHLTLLNAYQAFVTKGRKEAKFCHENNLNFKSMSRAVSIRAQLKRYLERFSINIDETLAGQASPEANVKKAEQIRRCLTSGYFAHAARMQPDGTFRNVEGNMVLHAHPSSLMFNRKADWVIFHEAMETGTKIFIRDVTKIEKGWLLEYAPEFYQITTDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKA8</accession>
    <name>S0DKA8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424931.1">
        <property type="nucleotide sequence ID" value="XM_023573163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKA8"/>
    <dbReference type="STRING" id="1279085.S0DKA8"/>
    <dbReference type="GeneID" id="35394040"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00555"/>
    <dbReference type="HOGENOM" id="CLU_002712_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038769">
        <property type="entry name" value="MTC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1216" mass="136860" checksum="8E6EEFA30E8F251C" modified="2013-09-18" version="1">MADPRAASSLSAYGRRDGPVTPEPPTRFSYDTAERGEHSMNALLHAPLSPERPLAFSDDETLPRYHHKSRGAAAVPSGLQAGRQKRARSKRPQKTQPSSAFLLQEPMATDDDSGNLRRAHRSKSRHKGKDVQEPYLSNGTRDLGLGISSGSGPRARIVSPDTSQEELHITKRNEAQRRGRRAHASQPGAPLDVDSTQIVNMALNLSESRRIASRRNISRGNPPRLAPVQDSQTGSNLRAHLQQQRKAVRGASPIPNQSLTPRLPGVRSSSPLRPSPFEATDASYRYHFSTSTLARAQKAREHLELMAQYRRLLQVLPPLKTGYDRPSASSPPGSPTEGKMHAFESREFMIPLGREYNPLQYIRNRKVRARERMVIDGEKQGFADVESVKDWVNEASERASRELLSSDGSILPPFPGAEEIDSQIATDSAAKVALRVRRPRVDWFFEACDLIADAYWLEQDHHKQLIEDRDLNKIYPQTGETLSRPISGQTDELGTGVPPFITETMEEMNGKANSNESNSSKPEIEFLEPSHRDRARQKLHEMGSFHRQTGSVHHRRFRRRGSSSDDSASEDDMPTEGKARRGTISSRETELLEKQMLEMVARDMRQQRLSHVQETEAEYMQPEDSTSPEPKPQTQLATSREWNMMDSKDSENRPIHNRASLEIPSLSKLGRNTGGGSQHGRNSKEHTDSPQPMSPELAPQYSLSAPPTGLQLSAPSSRSSSPSRNPFTKVKQIFRDKTRDESEEQALETEASSRRPSIPDPLPPTETKPLERHPSNSRPTFESHKHQRSVGSIRPRGDDQVGLRGMFKGPRIDTVIRGGVSRLGDMLWKKDIPMEGTTDVLSSDESDNDQPKGRSRISLNLSRTNSRRNKPEPQHGAKHFLDSMPQFQPMAEMHGQSTTDVKKLQPSQSRVEVSKVPAPDISGISSPSKPQQVEKVTIVEPAMSEAESCQESVKDGPRILEREGDEAAPMVRFNEPDNFRARKWSIANQAIPQEGQLSKREIARLRTLILTSGIKAMEISRRAQELKKPLPSNDLQELVSSPQSCPVGIPWVDIAKLTPKKSLPFDDALPCSDHFRLARQTLDVAIQTSIEQWQTSADKFTAQTRPKLEERIWCVRSRIADELSGMTREASDQADETGKDLALGQLLKVKHVTDLTDKMMRNRRRRFRWLRRGMWSVVEWVLVGFMWYVWFVVTIFRLFLGLGQGVWQGVRWLLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKM6</accession>
    <name>S0DKM6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424008.1">
        <property type="nucleotide sequence ID" value="XM_023577206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKM6"/>
    <dbReference type="STRING" id="1279085.S0DKM6"/>
    <dbReference type="GeneID" id="35395058"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01573"/>
    <dbReference type="HOGENOM" id="CLU_1669523_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049174">
        <property type="entry name" value="Beta-AFase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465:SF2">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="158" mass="17942" checksum="EBD0F844C3506BB9" modified="2013-09-18" version="1">MVDREMYLTGGISVMVQREDFGIDYLLPQGTDEGGCCAETCASIAFLTLAQRMLHLNLDSRYADFVEICLYNTIMTAMSLDDKSFTYINQLASSKTNKNVRERWFWCACCPPNLDGTIRQFGRLSLGLCAELQFKAGYSTITLRQKTDWPREGKADFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM66</accession>
    <name>S0DM66_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425800.1">
        <property type="nucleotide sequence ID" value="XM_023571505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM66"/>
    <dbReference type="STRING" id="1279085.S0DM66"/>
    <dbReference type="GeneID" id="35398607"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05126"/>
    <dbReference type="HOGENOM" id="CLU_060131_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25212" checksum="903746DFFF0EFFA3" modified="2013-09-18" version="1">MGGGPISPSSKAIPNAPLTLRRATIDDLDDITWVAVNGSPDDPGTDYRFPYRDKYPEDFWKWTRIEHEELFQRPDKLVILVVTAPVLDDGEVTHQPISYGVWDLKVTSDFIPGAYAKVLPAGLKKYFKRFGSEQIPLWEVVTHPDFRRRGAASMICEWGQKEADKDGKSLSLLATPMGKGLYLKLGYHVLGSVVVQVEGEEERVVFDAMVKHNKLIEGIVVRAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM88</accession>
    <name>S0DM88_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425621.1">
        <property type="nucleotide sequence ID" value="XM_023571290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM88"/>
    <dbReference type="GeneID" id="35398800"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05319"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="241" mass="25850" checksum="866FA34319788E32" modified="2013-09-18" version="1">MNLSRNIPRLVGKVAIVTGGGSGYGEGIAKRFAQEGAKVLITDLNKRGGERVVETDHDSISFLKADVGLQEDWRKVIETAKSRYGRLDCLVNNAGVTYHNKPTSSVTEEDFDRCFRVNVKGVFFGSQAFLPELIKQGEGGTMINVASVGATRPRPGLVWYNASKGAIWNATKGLAAEYGAHNIRINSVCTLLGGTGLFIANVPLQRLCKPEDVAGACLFLASDDGKFITGINMEVDGGRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMX2</accession>
    <name>S0DMX2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to ROG1 Protein with putative serine active lipase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_05052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425871.1">
        <property type="nucleotide sequence ID" value="XM_023571589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMX2"/>
    <dbReference type="STRING" id="1279085.S0DMX2"/>
    <dbReference type="GeneID" id="35398533"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05052"/>
    <dbReference type="HOGENOM" id="CLU_007367_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="332"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="437"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="628"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="734"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="799"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="938"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="810"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="824"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="939"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="978"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1089" mass="119757" checksum="D4671F89C9AA1275" modified="2013-09-18" version="1">MLLLHQVGSLKTGEVVRYTITYIPSQDRILPSPEKLFLRVRNTSAIALRAAFVHGPYTLSAAAYPAAFNPNEKFEYPERYGVPEFEPMVKAGGSWECELVVPVTIRQTAGLGSHGGFGKAPEHDHESASWIVEVSSQILFSTSAAVGFEVVLARDKKSLSLSSSSPVVGGQSQVPQPGKISDYQQGVEAKEGHHSAQPRGVFSRAIQLKVEDTAALWNTPRLPGWDDKGEGRAEKRSGADQHVESVVKTGDPETKGDESKPEKPKKKQKKVHMVVLTHGLHSNLGADMLFMKESIDAAVKQAKIDAKARRARERAARKKSGNGLVESDSHDTKDMDRVEGEDDDDDDDEEVIVRGYSGNSTKTERGIKYLGKRLARYVLSMTYPDQPFLPTGKGMTDAITHNFDKHDPQQKPVHKHSTIHLGKDGAHLHKAERPYKITSISFIAHSLGGLVQTYAIAYIQKHSPQFFDLIKPINFVALATPFLGLSNENPLYVKFALDSGLVGRTGKDLGLTWRAPTLARSGWGAIVGNLGETAHKKVYGETQPESKPLLRILPTGPAHTALKKFRNRTVYSNVVNDGIVPLRTSCLLFLDWQGLGRVEKARRDAGLVETVVGFGWAELTGTNQARQKQLGNGSAGQSGASSPKTHEDMREVPQPPSTAMVDDDRASLRSVATPYGDEVPSDSADSTNSGPLAGFFNFFKSNEPPKPPNVSQKQKKIYSKSQTLKLDELADGSVDTAAETASTKQSKVTTGHEGEDEMTAPPRTTIFESAGDLLNPKVPDVEYLIDPSKRPRTIFHDRVYHPADIPGPPLKRRPTTLVRRKTGQRQNSIGQASTSSADSSPYPHVNHEDSSLSAKDYDDTANTNPDKDIHEVIDTSNMRVEEKIARAYHKDLSWRKVLVKVEPDAHNNVLVRRMFANAYGWPVIKHLVDAHFSDSAASRLRDEDEHNRERARNMNEPPDEHGAELKKSRDNLASMTRTDSESREAMDKVSDLPKPQQSQRGSDASTHQRPKAERADSVTWSERDWHDSDCESDLDFGGDLPAPTSPSALHQQDKGKEAQGPSGGWNWAEKIVGKGASRAKSPVHEAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN62</accession>
    <name>S0DN62_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_01499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424074.1">
        <property type="nucleotide sequence ID" value="XM_023578028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN62"/>
    <dbReference type="STRING" id="1279085.S0DN62"/>
    <dbReference type="GeneID" id="35394984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01499"/>
    <dbReference type="HOGENOM" id="CLU_005100_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="556"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="751"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="757"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT61993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="773" mass="83601" checksum="44E89A67729CD39E" modified="2013-09-18" version="1">MSPSAIVESNEMATQSTFSYAQAAKGQGTAPASNPTAVADTAAPPQDAQASIADDDVPAPATDVKSIAATEHASSEAPETTEHRAAFSDKQGLESIPGSESDARSESTQSRRTDSRREDDSGRLERPWRRNEKTPGSSNTTARCVDEQDSRKARRNKKGKTSEKQPSDQTTEKEQEAVTEAPKVELSEAPIPIVNIWHKRKEAQQAKSVKPAPTPAEATVNGTSSRDEKKTEESATTPYTNGIKTQQKPASTARPERNGPRGSRIHEKDGKNEAPPSVEDSTAWPTPETAITAIKEDSKKKSADKTPEKSDRSDKDSQEDGSASKPRQKWVAMDYVPTVSFETQLPQMRSSKPRGGARGNRDAAPRSMANGVADKTASTAPANKTNDTKPKDNTNNAASQMAAVKRGAVDGVNSQKKAPASTGSEKAKDTTAQSSEISQSRDRHDGRSERGRGNYRGRGAHHGHSQSQHAISASGFHGQGANAARSQGYSPPLRQGGHGGMFTPPSQRGRGRNGANNFHRVSVPNGGSRMPVVQAQYSPYDYSMAAPMGAVPFHSLPFDNLLVLTIKTQIEYYFSIENLCKDEYLRQRMDSQGFVPLHFISAFSRIKQLTVDMNIIRAACEDSTEVDYVVGDDECERLRRRHNWEHFVYSMENRDELARNAGPSSVTFKNRHYHFPGGQFDDIAAMPYGAHAYPHGHALQQFAPHDANGVVPNGNTQLSAAVPDFSPSGTIPLVGPRGEVQVTSVEALTNGHAEQTAPLTNGVHSGEAYTTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNN1</accession>
    <name>S0DNN1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_01278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424274.1">
        <property type="nucleotide sequence ID" value="XM_023580506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNN1"/>
    <dbReference type="STRING" id="1279085.S0DNN1"/>
    <dbReference type="GeneID" id="35394763"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01278"/>
    <dbReference type="HOGENOM" id="CLU_030733_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT62193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="427" mass="47379" checksum="5F38BA961428E11E" modified="2013-09-18" version="1">MDSQASIQSAPSQGEASPIPNLKDRLPRLEPRKRRSATSNPTPIPETPALPTPPDTSNWTFKTPSRRILSKGDHDIFLSSPTCKLITAWVFGLAESVVDTPNSAVRDTDLSSPLKVILHILDETEQLVAKSPPNEQGGSRFGNKAFRGLLELAQSNCAAWHRDIGVQDEGAIAELSTYFCQSFGNGNRIDYGSGHELNFMTWLLCLYQLGLLEQSDFKPLVLRVFVRYLEVMRVIQMTYYLEPAGSHGVWGLDDYQFLPFLFGATQLLHHPYITPRAIHQDLTLEEFGHDYMYLGQVSFVNSTKTVKGLRWHSPMLDDISSARSWTKIDGGMRRMFVAEVLGKLPVMQHFLFGSLVPAADGMSEDTGTGEDENAEHDPHEGHDHTGKAHDGTGWGDCCGIKVPSSIAAAQEMKKRGGDQGLRRIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNS2</accession>
    <name>S0DNS2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to tubulin-folding cofactor D (Chaperone)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04748</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426152.1">
        <property type="nucleotide sequence ID" value="XM_023571928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNS2"/>
    <dbReference type="STRING" id="1279085.S0DNS2"/>
    <dbReference type="GeneID" id="35398229"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04748"/>
    <dbReference type="HOGENOM" id="CLU_003043_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="349"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="3">
        <location>
            <begin position="959"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT64071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1220" mass="134389" checksum="2D19611091086F46" modified="2013-09-18" version="1">MDAPEADVDIKLQKISADLLGDFDRSLPNFLWKPDGHGGTRVRSRVRAKEIFRLTNTLLDPFQELPQLLDPYLPKWIPLLAEAFLKHLQTRHRGKTLSSRSKLLVSVEFAICKIIYTFCKIRGEKIIVRFLNVEAKYLELLLSAIEESEQASVDDVALGKWSWEERYVVLLWLSHLLLAPFDLSTISSVDLQDVTVPEIPGLVWPENLPAITVRVIPLAIKYLGTPGKERDAAKALLVRMSIRRDMQQLGVLESLINWSLASLRPKKDQALQKTYFYLGVLSFLAGVLRASSDTSDMNPYLSTIFYAIHEISTGENALSKAIISLALARKMILKVIRSVVVLRLRQTPQNMASTELTETAIGYLLESVSDNDTPVRLAASKSLSIITLKLDPDMASQVVEAVLESLNRNVLWTKPAGGKPVRDLSAVNNLEWHGLMLTLSHLLYRRSPPTEQLSDIIHALLLGLSFEQRSMSGGSVGTNVRDAACFGIWALARRYASSELLAIPTHSVFAAKAHPATSSILQVLATELVVTASLDPAGNIRRGASAALQELVGRHPDTVEQGIWVVQTVDYHAVARRSRAIEEVAVNATRLASQYGEAIIDTLLGWRGIGDLDAASRRVSGAAFGVLTYELSDIKSGDSLARFKVIIQLLTDRLKTLQPRQVEERHGLLLCFASVLDKFPALFIPSAEKNSLELIDEILSTVSGALENLQSTAYRKPELLAEAASRLVVSALPILQISILGADSQQTLCPGRELLHPGNGSGYLGLVSALDSCDKDRSAVVARLISALRTIIPTWLNRSEQETIEPTAAASLILLILSKPVDRETLLRGWAETVQHRPTSRTSVHGVGYFSALTVAQPLVSSSGDVACQAILERWTWDSEVETRVAILQSLAQSNVLHNKPLAFLQLIAEGLDDYTTNARGDVGSHVRVHALRAVKTLWSKLDDSIVQGEWEKASVQALFFSVLRLAAEKLDRVRPEAQAAVALVLENGHAKHFRELTFSSRAYFESLLELQAGARLRPLLGDVAKGDTEKWMTELMSGFVGSADTGNEDLVIASRAALCDFCEANHENLDLICHAMLQNLKSRQGQDRVIVPTLEIIAFLFQMQLFQKSGVNLRSLCMQTQKASYKTGNVRKLEACIKVYCGIASMAGQEGAETGVQEARKRLGALLHHPWPKVRSMVVDGLWGVLEEEEEIAQKLKGVDWGQAGKVQIKTAVEELRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNT4</accession>
    <name>S0DNT4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to adult brain protein 239</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426156.1">
        <property type="nucleotide sequence ID" value="XM_023571933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNT4"/>
    <dbReference type="GeneID" id="35398225"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04744"/>
    <dbReference type="HOGENOM" id="CLU_041441_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="323" mass="36597" checksum="6E8608AB9300AC7B" modified="2013-09-18" version="1">MGLLSCIGLRRRNQWEPMTLLDNLISSPLTYLAFLFYHAVLLLRGRPFHPPRDKPAIRVVCISDTHDLKVDIPSGDILIHAGDLTDSGTVADIQKQLDWLREQPHPVKVVVAGNHDSWFDIKSRHEEDARSGAKPNMEGLHYLESGLTVQKIKGRTVNIFGVPDIPSIGPKEFAFQYTQDNHPWLSKVPPQTDILITHCPPKHHLDLGLGDSNLLREVWRVKPRLHVFGHVHFGYGEESAFFDAFQETYERIMSRPRRGLIRDFIPNEAWLDYLRFLAQGLHTVAWKWLMSGPGSNNGSLMVNAAQMKGNSGKVKSRAIVVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP10</accession>
    <name>S0DP10_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426247.1">
        <property type="nucleotide sequence ID" value="XM_023572052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP10"/>
    <dbReference type="GeneID" id="35398120"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04639"/>
    <dbReference type="HOGENOM" id="CLU_022029_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="491" mass="54467" checksum="884FBBB308831CE6" modified="2013-09-18" version="1">MAAKRDLEDTDDGEVLAPQPKRPKKQGGKTRQHQNSGIDPTWGQKYVFAGNGNTTTIPEGEEDDFEDDSEAMAYLNSVRQEANGIPHLLVAPKVQIGPQLPLELRNDDQEQDEQPIDRSVYNNGVGDSRGWYEDGAYMAMPDNAAEDEGYEGGEYPDDYEDESYEEAALNEAYFASVMDQYLRLRSILHADLPPNAVSRVVKARLKTDAPAENQSAAIATWSRLLRETDPHPLQVALMSKDTTLRILRILLGGKFLRQGYTLPERTSRWIWALLARMPDKGELNYAEIGWIRDLGRRAVLLGRSLAEMAALREELAEGGLGAHEAVDGSSSDEEVLADPEDMEVEGALSSGQDEDEPKPAGSRNEAEKTTKGTEPTAKSPPRPDAEEGEIEDEDEDEDEDVAMEIASDSEAEEGEVAAQEPQENLEAARERLLARISNGVTSEDEEDLEKESAKQRLRANLRATLNMILTIAGEFYGQRDLLEFREPFVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPU4</accession>
    <name>S0DPU4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_00853</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425518.1">
        <property type="nucleotide sequence ID" value="XM_023570441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPU4"/>
    <dbReference type="STRING" id="1279085.S0DPU4"/>
    <dbReference type="GeneID" id="35394338"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00853"/>
    <dbReference type="HOGENOM" id="CLU_016207_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="123"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT63437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="450" mass="48588" checksum="5608B8DDD62E569D" modified="2013-09-18" version="1">MPQSALLLGSGFVATPAVEVLAKAGVHVTVACRTLASAKNLAGTFDNTNAISLDVNDSAALEEAVAKHDITISLIPYTYHVAVIKAAIKAKKNVVTTSYVSPAMEELHEEAKAAGITVLNEIGVDPGVDHLYAVDFIDRIQQEGGKIKSFKSFCGGLPAPENSNNPLGYKFSWSSRGVLLALKNNAKYYEDNKLVDITGVDLMGTAKPYHTGYLGYNFVAYGNRDSTGYRQRYRIPDAETVVRGTIRYNGFPQFVKALVDIGFLSVDEQDFFKQAIPWKEALQKFIGASSSSEQDLIKAVLSKTSISDESVKSQVLAGLKWIGVFSDAKTTPRGTALDTLCATLEQKMAYEDGERDLVFLQHTFEVVNKDGSQNTWTSTLIEYGAPEGSGGYSAMSKLVGVPCGVATKMVLDGTITDKGVVAPVYPSLARTLMKQLKADHGIECKEKIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ59</accession>
    <name>S0DQ59_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426800.1">
        <property type="nucleotide sequence ID" value="XM_023572728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ59"/>
    <dbReference type="STRING" id="1279085.S0DQ59"/>
    <dbReference type="GeneID" id="35397514"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04033"/>
    <dbReference type="HOGENOM" id="CLU_006926_3_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="699" mass="77443" checksum="E7629A97300860DC" modified="2013-09-18" version="1">MPATQNGQFRIIKKCAKACKRCRSMKVKCSGAQPCLRCGRKNERCIYEAEEKKVSVPESYLRALERRQDGLPSPGSLGNGSRPRPRHSSVSDYGISGVVTRDASMTADGDLTLGTPQDHDENDETNEAASLSTNDVLEPAFRQNPLVDNDYVFGQAMGRYWYMGPASSWAFCRRVLALVGKHLPEANNEPLPWHLDGVAFRLQWRPLMPDEPPDISNLPPSDYAYFLIQTARFYLGPLASLIDEAEFLQHFKELYQDASAKAASCKLWYAQYLLMIAFGKAFLGGKSADGSPPGYQYAARAMPLMPELAGIALDPVLSAQALTLAAIYFQSIDMRVAAYQHIGQALRICVLSGFHRHMPEEAVGAQHSKRCHIVFWVVYMLDQEFAALIGATSAIRDEDITNKLPSQADSSLSSLSLTLHVQLARLIARLLGTVYGVGKDYDGTLFSNTQSILRNLAELNRDLNNIINNHFRDSISKASRIATRLLLQYHHCVVLTTRPQIMCALHMHIEQSKTQLLTHGLSLSPPVASLIQSCVSSAQAILKTLRALADEDLIEAFLPFQIEYASSSAFLLHLIPIICPPLLSDDSWRDDARYVFDTLIAKGSLIAPLRKVELEQLEQKLSALTPASNIATPEVPNQVEEHVSVQEEENGEPELDEHVSDETGWDLFAANAMAGLTPGELLDLAEQLDVDSFLYQPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQY9</accession>
    <name>S0DQY9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to cytochrome p450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425913.1">
        <property type="nucleotide sequence ID" value="XM_023571639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQY9"/>
    <dbReference type="STRING" id="1279085.S0DQY9"/>
    <dbReference type="GeneID" id="35398487"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05006"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="536" mass="61208" checksum="4A1BB5179E8FA0F0" modified="2013-09-18" version="1">MIEHYPSQALSGLTLAIATILLLAWAHWRSQHTLPLPPGPPSEFLLGHFRVIPKDNAAAVYAKWSREYNSDIIHVRSLGRSTVVLNSADVARDILDKKGANFCDRPQFTLLEVMGWGKTLTFLPFGERWQMHRKLLQTSFSNTNVRQWHSLQITEARRTIRNILKKPETWETSLRRLAVAIVLQVSYGTQVLEDDDPYIQIANDAMYATGNGGVPANSIVDLVPFVRYLPDCIVRDWSLRFARQWRWAIRKLHDIPFAAAQAEYHRYDHHRNTSLAHNLLREYKDKESRGQEQQWSLDDIKGAAGAVFIAGADTTWATCVIFILNMVLHPEIQDKAQQELDTVIGFDKLPDFSDRPALVYIEHVVQEIYRWSPLAPLGIPHKSLHDDIYKGMHIPKDAPLRCCHHSDVTRWGEYLISTRTVVYANAYAMAHDERVYKDPHDFNPDRYEAGEPFPVGNFGFGRRVCVGRFLADNSVWIMVATMLSVLRFCKKMSSDGKLIEPRVRFTNGGTCHPEHFDCVIKPRSLAAEALVNSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRI8</accession>
    <name>S0DRI8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427126.1">
        <property type="nucleotide sequence ID" value="XM_023572741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRI8"/>
    <dbReference type="STRING" id="1279085.S0DRI8"/>
    <dbReference type="GeneID" id="35397503"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04022"/>
    <dbReference type="HOGENOM" id="CLU_028281_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="130"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="445" mass="49704" checksum="C17D19813EF6C635" modified="2013-09-18" version="1">MVRESGFDMVPRLSGYEDQEIWEEFIEHVQTVYKDESAFKIKADYMVFEEGKQLLLPLEGHKFLRFSSIPDDDSHVEFHINLVTDIARDYFGSRVRSWQSALGESGYYSEEEVNDSYRLYEQLPISIYGLLFEVRVIPGKGRGLIARFDIPAGTQIFCEKPLLVASTMSPGNLEATAAPRLKALSKSEQQEFLSLHNSFPGEDPFSGIIRTNALPCGPGSIVGAVYPTLSLINHSCLPNSHNNWDSKANHGTIHAIGPIKAGEEITISYDEGGPSNVRKHKLKMSFGFDCACSLCSLSPSELQASDDRRVRIQQLYASIGNASTMRNNPNSSLKDCLSLLHTLQEEYGACAAPYIARLYYNAFEICISHGDVGRAITFADRSYRGRLICEGEDSPETSRMKSFALEPKKHGSFGAFSTRWKTGEEKAPNGNGTVQFEKWLFRQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSB1</accession>
    <name>S0DSB1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_04516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426358.1">
        <property type="nucleotide sequence ID" value="XM_023572188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSB1"/>
    <dbReference type="STRING" id="1279085.S0DSB1"/>
    <dbReference type="GeneID" id="35397997"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04516"/>
    <dbReference type="HOGENOM" id="CLU_032263_2_0_1"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="8">
        <location>
            <begin position="58"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="9">
        <location>
            <begin position="201"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT64277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="243" mass="27764" checksum="CE8950FCF2F1139F" modified="2013-09-18" version="1">MALHSADTSKLIFAPAGHQATGQAEQFTKGTLVRSQLNPASPIPQFHAWFSRAQENDSGVDHPESCTLSTASLPSGRISSRTVYLKELDNRGFVIYTNLGTSRKAADIATNPRAAMLFFWESLQRQVHVEGRVEKISREESQTYYDTRARGSRIGAWASRQSQVLEPQGDDDDGRKQLEGWVKEVEKRFEGQEKIPVPEFWGGLRIIPDRIEFWQGRESRLHDRFVYEREGEEEEWTLKRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSI9</accession>
    <name>S0DSI9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427605.1">
        <property type="nucleotide sequence ID" value="XM_023574205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSI9"/>
    <dbReference type="STRING" id="1279085.S0DSI9"/>
    <dbReference type="GeneID" id="35395954"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02472"/>
    <dbReference type="HOGENOM" id="CLU_844804_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002038">
        <property type="entry name" value="Osteopontin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00216">
        <property type="entry name" value="OSTEOPONTIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="329" mass="36988" checksum="39379B3E09770103" modified="2013-09-18" version="1">MQRFPIPPPTWAAYRQHQEYYDLLYQGLNGSWYNHNTVVPGFVELPADCVPRPPAVNQASSSRAGPDPINPTMHCDKQLGKHCDKACCKLKPKARGRRVTIATASDEENGVVTDTEGNITDSSNPVVKSKMTTKAKGKDKAVQTDDDASADDEESDDEDDDSDDEDDDSDDEDDDSDDEDDDSGDEDDDSDDEDDSDDDEESDEDSDDDNNKIAKSNHVYGAMYPTHHHPQPDAPWVKGDCALLATIDSKYKRSRWLEMQANFYNVTGQMVPLVCFKARCERVEAEKAERSKTRELEKRMNKVEDWIAKQEREKSAESEDSEDSDNSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTV6</accession>
    <name>S0DTV6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to proteins containing regions of low-complexity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427956.1">
        <property type="nucleotide sequence ID" value="XM_023574635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTV6"/>
    <dbReference type="STRING" id="1279085.S0DTV6"/>
    <dbReference type="GeneID" id="35396337"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02855"/>
    <dbReference type="HOGENOM" id="CLU_007392_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="881" mass="98905" checksum="54046FC818136362" modified="2013-09-18" version="1">MGASDSKLVFKRGIFRLSEERHIPADDAYWTSFWELPESSEDVFSLFTPADIRRTRDRALENLETLILAITSRLFILRHHPSFPDPELAPEREALNCIRVLTRILPYLYEKESLSDWEQQFFWAQRRKRTRHGAIANEILFDEAQEAERKTQTAEFEEVKPLAEELVDTLVDLLFFSDLTLPRQPNGRPKVSYAIWQSGVGCNTAVATTKEYESSRSEILRLLLTLSGQSLYMTAGVLPQNGVRTLTHLCACPDKQVVLSVLCSLLNTTLKYNPATWRVPYNTLVFKDGKQMLVTYSLQFLLVLLLYPIPENPSNPSPKHSYRHFLGRLHRPQDFQFIVDGMTRILNQPLQEKTSYLPGSQSPGHFAPEILMLFWEILQCNKRFRSFIVDTERAHDFVVLALFYALEYKNDATKQGVVRMCAFLLQTLSVETNFGVNLNKYFEGQESLPTSIRVPGFRGTYADFLIHSIYNLITTSQGKLSAIYPALLAVINNIAPYLEGLSSTSSAKLMQLFSSMSSPSFLLANETNHALLHSLLESISSILENKYPKNPELVFAILKNKKRVEALRSFTLESGQEEIERRNRRRKDSGHHFDPFDAASVRSSVDSLRSPNSAQPRHSSLEEVPEDGAFAIGDDDDDDDDDDDNDDSDDEEQQETPARSTSSEAPSRRSSIPNVEDAVPTQLRGMSEKARGKMPAGVPTFSRQNSTTSLGGRSISGQSQAGAFEPSAHWIDSWLLELPLHTILAVIQQVSALLPRQELAADMPTPETLRRISGVHVVGIEPSAPRVHSFEWSQLALGWYESLLWGVIFTTEMQVSRGTMGIWNGTAIKLFRVQETAPEGPTLTSPRGAVDAVGSNIVSRIGQINLRGGPQGSSQAPQRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTW5</accession>
    <name>S0DTW5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_03899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426923.1">
        <property type="nucleotide sequence ID" value="XM_023572878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTW5"/>
    <dbReference type="STRING" id="1279085.S0DTW5"/>
    <dbReference type="GeneID" id="35397380"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03899"/>
    <dbReference type="HOGENOM" id="CLU_010591_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495187" description="LysM domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="116"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="197"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT64842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="260" mass="27968" checksum="0AA6E601E82A7F12" modified="2013-09-18" version="1">MHLKHLLLFAGNLLPVFGAATKSSASAKAPEPQQPGIVSNCKSYYLVQKGETCFSVAAKNKISLSDFQEWNPKTGTDCNALLANAYACVSVTETKGPSPAKKYSPTQAGIAKNCAKYALVGKATTCKSIETQNKLSFANFFKWNPAVGKHCQGLKKGYYVCVGVEKAVTPTPTTPENVTGNKAPSPVQKGITKSCNEYHRVSKGDTCSAVASEFKIDLDEFYQWNPAVGSKCENLWANYYYCVSVAGEKAKASVHTPSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU00</accession>
    <name>S0DU00_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LRR-containing protein second PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428012.1">
        <property type="nucleotide sequence ID" value="XM_023574704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU00"/>
    <dbReference type="STRING" id="1279085.S0DU00"/>
    <dbReference type="GeneID" id="35396399"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02917"/>
    <dbReference type="HOGENOM" id="CLU_003789_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRR-containing protein second PH" evidence="2">
        <location>
            <begin position="262"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1185" mass="131988" checksum="2A80720C4452FF0E" modified="2013-09-18" version="1">MNAEKWKRRTLPTLKTPPVPIPTDGNKEFDNVDGKKPRVFSKALRSLSNSSMESMSQSPSRSSSSIRRLQKTHSGSGSMIDRIHRRVSIASPMSASAPEFPSVTPEVPYSSMELIQYGPLKTDVSLLKARAEYLVLTDTCLIKFGSMEGARAAFPQIKSGSGTLKPSSAHHNSHRSSSDVRIEIPLRSIVGVFNEEGSSPRFGVEIWWFSQWPKLAYSKTHLFFMLPKDRDDWLASIQQACRVSHRRAPSPSLIPGNLKARINHIVETTEPDSNANAAKILTFPVVKRTIGLPQKTNSADESQHFVDGSSFYIVIGPAMLYFLEVLKADYATTPGDLRVKVQSYGTVSLIQFRASVASHEQRFVMSFRLPLSRENRLELASVHYRHVIEAMTKVDRELKPMWPQHLQKAIFDIKGLPPPLQLTSGNDLGGLERSLHAYCAAFKPAFRLLPPGAQPYSTLQLLALFRALRYNSYFKELSFRNIDLSGIAGKKDYSHFGDTIAYTSLNGVKISEEHYDILMQSSVLSQEMHALAFSSESIRSMDLRNILGPRSTIGRSKDPEGARRVSSEVLRPILLLLKRQACLCHSITMSGNLIASSDIEELANLLVLDEVYMKKLDLSNCGLGDEGLTALWAGIPGQGANLQHIDTSENQGTIKFETIRDSLSQLRAIRKLNIAGNTRLPFDVPLFEDHVLSSWSLEELDLSGIYLNSSTVDILTAYLASQNSENLRVLRLSKCGLTGAQIAQMFYAMGQARQITLYINGNRLDEGIDDLCAVISECFGPWGLFVQMVEFALEASYIKLLKALTANQTIECLSLAGTATPDSASETACRALSDLFSHNHTIRFLDLSGFDSKLDEGRLGREFSKALSGLRFNTRLEHLRVRSQLLNVNIGDLAEAISANKTLHSLDCEGNDFNLSNFRHLVRHLSDSTTIRYFSAFSDRDLAQTIQKSVDNAVATATSARRQSMISKLRHEKVPQSISEPLAQQLRDGWEDAVRTQQEVLERNQLLFEEGEDGRHDSGQDGFMLCDGEEDFSKAFGGLALRAFESKRAMNRRASNPYLNNKRASMISLGPARLVSAEPGARVTRSWSRSYSIVSSEGGISATESPSTGSAIPTPPEPESPVEKEYLVENQQDRNEEPLDYEYSFADPHDPDFGLELRAHRRFWSDEAGCIEEEEHGVQFEERNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVG5</accession>
    <name>S0DVG5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428615.1">
        <property type="nucleotide sequence ID" value="XM_023575432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVG5"/>
    <dbReference type="STRING" id="1279085.S0DVG5"/>
    <dbReference type="GeneID" id="35397052"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03570"/>
    <dbReference type="HOGENOM" id="CLU_028906_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="379" mass="42403" checksum="28167E10522A764B" modified="2013-09-18" version="1">MDARQDADNLAWDQSDERWEKALKHVRASATCRKIEGFASRTFGKPATLVTPLIIGGFNIVYHFKVEGLSSQVLVRLPCADQAMFPEEKTTAETFHHGIDEEIGLYMIIKDLGTRRGMSHALEAPRGDPNDAPILNPKMSETHLKDLYSKMAECFLQLAQLKFPCIGSLAESSPGTCEVLGRPISLNMNNMFQLSNVPSSVFPAEVTAYSTGDEWYTMLAERKMSTLVFQHNDMISSEDDCRTKYIARKLFHRLAGQNGLTKFGLPDDDWSASSELSNATLSSPDNSGSFRLWSDDFRPVNVLINDDSDVVGAIDWEFAHLGPSQFTLDPSWWLLLEVPEMSDDGIDDWASTYEQRLETWLSAVEEVEKETSSDLPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVU5</accession>
    <name>S0DVU5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable GTP-binding protein Drab11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428765.1">
        <property type="nucleotide sequence ID" value="XM_023574022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVU5"/>
    <dbReference type="STRING" id="1279085.S0DVU5"/>
    <dbReference type="GeneID" id="35395789"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02307"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="181" mass="20312" checksum="0C1EFA84BF850285" modified="2013-09-18" version="1">MGDIPYDYRWKVVLLGDSTVGKSNIASQFMQGEFQPDSSPTIGVKPTTKIVQCNSKAVKVNIWDTAGLEKYRAPVVYYNDAVAVMLVYDITKRQSFENAARWLDEARRHGEPGIVFMVVGNKTDLERRRSVTTEEGKKFAKLNKLMFIETSACENTQVDLAFQRILNGMADPSDIPHEAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWQ7</accession>
    <name>S0DWQ7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to nitrate assimilation regulatory protein nirA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428976.1">
        <property type="nucleotide sequence ID" value="XM_023575704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWQ7"/>
    <dbReference type="STRING" id="1279085.S0DWQ7"/>
    <dbReference type="GeneID" id="35406519"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13063"/>
    <dbReference type="HOGENOM" id="CLU_011581_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT66895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="665" mass="75221" checksum="FC6636E4EF0224FC" modified="2013-09-18" version="1">MKAACVQCRVRKVRCDGTVPRCRTCERLNFQCSFEQDGSSGQSAPRIPPKCRGAKACQECRAMKVRCSGDVPKCTNCTRRNRPCTYVSKAGSSTTEASSSRDDSASVTTSQAAISPRKQRPSIASSSQSIPFDSIEENPPFVPDDGVISLVNQYFERLYPLSAFCFLHRATVIQRCHDKTIDRALQLAICSITAIYFDQCQGERDAWAGEAEQLILDRLEQPSIFKIQASLLLIRYRAAVGQFPRAFIMAGLAARWAAAIRLNYEHSKLSPVAQEVRRRTFWSLSLLEDSFCVGLKEFELFDADTIYLQLPCQDADFQQERHVPTGYLQPGKGLEPEVLRTRAAFVRVAFIRRAIVRLNRRINVKEVNLPELLSSMEKFQNDLLRLRTRLAPCDQYPPSYTQDVHLSPQYFVMHMNWHLTHCDLYRIFLTGYPESTTDTMIEGISAAEKGLMKDKCLSHAEQIVKVLSDFVQHKEENEILELVLFGTYTGKDNTGLPMQMAINKAQLCLDVVTRYFAFSEQLKSMRQELERVIQQHKAWLESSDHRAITTTTDPNPAQSSKLAKDAYIRQRLAIHSLLRQSDFVDDSHDAAPAAPLEAESEQQSPEQQSPEQQTNWGIRDPVTDQNLMFGLPYGGGLDLNAWASSMAGNQDLNGLLTDFDEQYMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX44</accession>
    <name>S0DX44_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to UTP6-U3 snoRNP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429162.1">
        <property type="nucleotide sequence ID" value="XM_023575930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX44"/>
    <dbReference type="STRING" id="1279085.S0DX44"/>
    <dbReference type="GeneID" id="35406718"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13264"/>
    <dbReference type="HOGENOM" id="CLU_026025_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="395" mass="45615" checksum="797D1B03AFD1C544" modified="2013-09-18" version="1">MAGVADKARFYLERAVPQLREWEEKEIFSKDEIRTIVQKRNDYEHRVLSPGNKPSDWSSYAQWEQSLESLRSKRCKRLRIRHLQSAHAGQGRTLAIYERGVNRHPGSSALWREYLSYTSSVKASKRWRKTMTNALRMMPTDPELWTMAGRRSAKNGDMAAARGFFMRGCRFCTTNEKLWVEYARTEMEWLEKVDKRKAVAKPGQDVLRPDREEDGDELRLVDSDDDEDDDDLPEPSNAQAKVIDKQTAQHLKSNPAMDGAIPMAIFDISKKQAFFSANTAEVFFDLFVSFVHVPAQPRISQHVLDTLDQEYPNHPATCNVHIRQPIMGLNPQTAEFPKNLREVLSRLNRYLETTTDRTELQKKTVAWIDGYLALDVLDEGIRAVLEHTKQKMESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX49</accession>
    <name>S0DX49_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428068.1">
        <property type="nucleotide sequence ID" value="XM_023574774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX49"/>
    <dbReference type="STRING" id="1279085.S0DX49"/>
    <dbReference type="GeneID" id="35396462"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02980"/>
    <dbReference type="HOGENOM" id="CLU_016972_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005710833" description="endo-1,3(4)-beta-glucanase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="12"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT65987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="495" mass="51410" checksum="57186C969A6D079A" modified="2013-09-18" version="1">MHSSILALGLTALFNGAFAQNNSYSQYSLKTTYDSSNFFEAFEFFNEEDPTHGFVDYVDADAANSEGLAGYVDGAVYMGVDYQTKNPSNGRRSVRVTSHDAFTHGLFVADIAHMPGSIPGVWPAYWMFGPNWPTSGEIDILEGVNTQTENKISLHTGPGCSITNDGTTQGTTLESENCDSAGAAAGCGQNTSDNQNYGDGFNDIGGGVYATEWTSDHIAVWFFHRGRIPQDIQSGNPTPSSWGPPAAKFNGGKGCNIDDHFKENNIVFDTTFCGDWAGSPDVWGKNPETSSLGDCKDYVANNPADFKNAYWLVNSIKVYVQGGSYGGGGGNGTTGGGNSGSGNSGSGNSGNGNSGNGNSGNGNSGNGNSGNGNSGNGNSGNGNSGNGNSGNGQSGNGDGQTNPPSSTQPGQGTQNGDGYSPDSQQGQDQGNSYSPEQQQGQGGGYSTGQSYDNGQYHVPGAYKTSKPQSSSTTSWDGNGWRVGSKRSVISKRYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXB4</accession>
    <name>S0DXB4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type c subunit family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428108.1">
        <property type="nucleotide sequence ID" value="XM_023574820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXB4"/>
    <dbReference type="STRING" id="1279085.S0DXB4"/>
    <dbReference type="GeneID" id="35396502"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03020"/>
    <dbReference type="HOGENOM" id="CLU_014048_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52205" checksum="B12BBD4C42895500" modified="2013-09-18" version="1">MALRLALRAPRSRLYNCLSTTARRVYSTSKQSDYFTVELSPKIKDPSRLLQTVRSQINITNPSRHDAAVILATPQYAQWLGKNEFMSEFVDMLSGSDGTGEFHTLGAVVDHIAPPVPNNKPIQGISILRGDLDGILPGLWTEAPPKEWSDGGKVSALTMDLGSPHITIPLTNTTFQNHRTSTLIISRYDLSTGSPKLIEQTDKKHLQKVTIPVRKRLSSINDLGIWAPLVPLTQPRVVTESFGNIVRRIDIEDESVPASSELEPAVDELHASKSDLVQSPMGIWAMITPPTFVQSGDSSPYVNPDPEATFSDGQSITELTAVTSDQLGNLYRQGGRLYQVLSGGGGWGAKKGLLSLDPEQTHFVVSEEEEMQRFIQAMEGGNFVPVSSKIQFFVSTDASAKEPVGNKQTGVVFGTSSKVEVETDVNPSQPEALLLENHFGALSNVGIFVTSSDASMFLKPGFNNDWKLNVPNSRIYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYD7</accession>
    <name>S0DYD7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429622.1">
        <property type="nucleotide sequence ID" value="XM_023576377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYD7"/>
    <dbReference type="GeneID" id="35407120"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13666"/>
    <dbReference type="HOGENOM" id="CLU_036424_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="416" mass="47501" checksum="0413F38821D3B946" modified="2013-09-18" version="1">MGGRPGIYVHLEMGVPLPKIMTKDRHITYVSKSMRDRANQFPRQLPPTNTNYLNAPAQYQPAHQQMPTQAQEPQTQPQQQFTQPISNLPPHIYSRDPVSIGMAHEPTYQPYRPQQPQHHIREYYAPATPAEQQQRETHTEELRLSSRSAERSTHERGRSAPPPLNNSPWDVASNNSGGEPQVWKALPATPNQFRLGEGDMPWDGWNFPMGFHDNNGDDDNNEGGEGRTRSREASLRATWGPEFPGEPSRYVQPVQVDDRARSKAKDIQSLASALMTVDNGFEDQWWYQGPRLVHLDGTTVMVPTAVPRSSFHPDHQQSSVGWAISQEEGQQQKDLKYQHQLQQNRREQEQQRYQRNRQRHLSLQEEQLASFVSLNTSFQPVSPRSSLADIVSPFGRLSESAVELWGTTAVFDHEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYF0</accession>
    <name>S0DYF0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427574.1">
        <property type="nucleotide sequence ID" value="XM_023574167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYF0"/>
    <dbReference type="STRING" id="1279085.S0DYF0"/>
    <dbReference type="GeneID" id="35395919"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02437"/>
    <dbReference type="HOGENOM" id="CLU_015936_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="557" mass="63293" checksum="91909E2C71317386" modified="2013-09-18" version="1">MSHNIDQLAKDCGKCFERLEEQLGYSTIASISKYNKYVGFKNLQSRFTRWKRNAGADSLQQDLHNNTRIRSQVIRLLSHIRRLLEDALAITVGSQVPWDQIEEEEEEDSQSEEEGQSWEISPETEIEQILAHIADSIDDLSYLGAALRDTLTNDRNTDETSRFEPFDVQYVLSKYPVTDKVIAERLGNAISARRQRFQNQQSTEQSSHHSKGSLADEPTLEALISQLDLEDLTYWGTERKGLLDENSSETSSVASEDLQAPRIPPLPQRATDERPIRCPCCQQMIRVLSTKDWKKHVYRDLRPYICLEHDCSAPHHRYARQKDWIHHVLEEHWRIYAYPFGCNLGFTSRNGCRDHLSQKHVDQRHLSEIEDLVQLSTVGKTEIPDKTTCPLCKKLLQNIETYRNHIGQHQKQLALLAISLDPTMAEEASLQPSAETEIDEHYIASQDTETSENEGPVSTDKGKKVASTLDDSGLGEQSDTSKSKSESFPGGREDRWGGRRKSEGKSFPDSSSSNPGRSRRGLSCWQCCNCDCGWMRLDINPSCPLCGVPRCGSCIYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ08</accession>
    <name>S0DZ08_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427779.1">
        <property type="nucleotide sequence ID" value="XM_023574423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ08"/>
    <dbReference type="STRING" id="1279085.S0DZ08"/>
    <dbReference type="GeneID" id="35396147"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02665"/>
    <dbReference type="HOGENOM" id="CLU_011409_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT65698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="770" mass="85172" checksum="99FF47CB979A1660" modified="2013-09-18" version="1">MNHAASSSSRDKAAATPTTESQAQVQSVSTSTATIFPITDLTTHPSSIPHPASVNAFNSIDIPYTESSYSSSNVSPASTSTPATPITGAGNTERIATTRSPSVSAASTSTKTTSVASTTSASSDLVAPSAAPPAKAKRVRTSKPKVKTGCANCKQRRIKCDEARPACTQCVRSNKTCTGYPPPSRSSRPFEEIRIAPKPMPAYDAQASSSTSIAPLHGDYHLLPRRAHQRSILRTTSPGTTSPSPTTYHPSSVMQIQPNESFYLDIFRSHTANELSGFFNNLFWTHYVLQACHSEDAIKCAVIALGALYQTLEQTAVLNMHSGSEMGGDARVELVRGHWQVAIRRYGDACNALVKLNTQDQRSHRTSIMANVLLACFDSFIGDHRQAIHQIQTGLGLLDIFRTQQRQRLLPVSENSLEEELVVIFTRLAIQAKSYDMAFHFPQPFSIRLSSQSQTQSPGPSGTTTPSQEEPFSIPETFTSVVEARVACDALNARIMRYIEELFAMKTDLKSTLPQSWLDYGLHFKDYLDAWGKAFDNLFFTRHNPSVSLQEKAGIAALKMLSTNSRILYLMMFSDKESDFDNFLPQFQTIVDLGTEIVGDEERRAASRDCPDPEHCQHRQRENWQSQELFPAMGFSAPHLKPRFAADIGIVAPLFVVATKCRDPGTRRRAIQLLRSSSRREGMWDSEMVANISAWVMNLEESEALSMGVESYHVDGITRPIPRIVPEEKRFTIRSVDFDLRTRVADLQVGTRGLPPGIPDSKFRQTRLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0E056</accession>
    <name>S0E056_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to NOL1R protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_03095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428179.1">
        <property type="nucleotide sequence ID" value="XM_023574904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E056"/>
    <dbReference type="STRING" id="1279085.S0E056"/>
    <dbReference type="GeneID" id="35396577"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03095"/>
    <dbReference type="HOGENOM" id="CLU_005316_7_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000006">
        <property type="entry name" value="NOL1/NOP2/Sun domain family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="237"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT66098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="606" mass="67239" checksum="FD82AA821D38F417" modified="2013-09-18" version="1">MSLYHEAAEILAGSSFEGGSLKSRVFKKKNLKSAPNQVYALVLESCKWSLILKEVIERSELLKLERKLTPTLSLLLVHDLLLAKKGIALPQGHGLRASIERHKGRISSEFKLARLRRKIPTLEALREQVERQCAGEEANYPRWVRVNAVKSTLEEQLETTFSKYSRATSIKEVVTNTGRLIYIDPHVPNLLAITAGTDLTKTEAYTAGKIILQDKASCFPAYLLDPRAEDGDLIDACSAPGNKTTHLAAILKEHRPETSTPEQTIYAFEKDSRRAQTLEKMVKIAGSKPVTNIGFGQDFLQVDPMAEKYKSVGALLLDPSCSGSGIVGRDSMPDLHLPEGISSTGKGPTSKQNGRKRKHEQTEATEDRIMIDDDGNETAIKSEKDLETRLEALSSFQLTLLLHAFKFPSAKRITYSTCSIHMQENERVVMRALESDIAKQRGWRILLRKDQVSGLREWPVRGLSEACGGDEDIAEACIRSYKDDGQGVMGFFVAGFVRPDVQNIGTSSNEGPYLRDDNGVIIRDMLGMPALKTTGEHVSLTERDDKSGDRKEEEEDTEEDQEEDEDPESDSTSSTAAHDLNARQIAFDARQGSSTDEDDEWGGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0Q3</accession>
    <name>S0E0Q3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_07006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430315.1">
        <property type="nucleotide sequence ID" value="XM_023577210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0Q3"/>
    <dbReference type="STRING" id="1279085.S0E0Q3"/>
    <dbReference type="GeneID" id="35400483"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07006"/>
    <dbReference type="HOGENOM" id="CLU_063916_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="WSC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="7">
        <location>
            <begin position="82"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT68235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="192" mass="20980" checksum="A39A808DA503A2C2" modified="2013-09-18" version="1">MTLESCASFCSGFTYFGTENSRECYCGNQLNFGSYQALNQKDCSATCAGDKTDYCGGTLRLQLYKAGAKTTTTPSVDQGNKNFTSYSCVSEPFLGRLLPQLVMNDGNSMTIDTCLEKCWMYKYAGVENGRECWCGNTINWQGLLPTFGQGKNVSMTDCNIGCPGNNLAYCGGLARMNLYINKSSALAFFEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1A9</accession>
    <name>S0E1A9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to HD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430611.1">
        <property type="nucleotide sequence ID" value="XM_023577557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1A9"/>
    <dbReference type="STRING" id="1279085.S0E1A9"/>
    <dbReference type="GeneID" id="35400796"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07319"/>
    <dbReference type="HOGENOM" id="CLU_036524_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="207" mass="23318" checksum="E45476A13FAEE4D8" modified="2013-09-18" version="1">MTTQDWSVDDALVGKVTNYVEEYMSKYDASHDFNHIKRVLRLSQHIQSHTPSTRQDLVTLAALLHDVGDKKYLRPSEDPSRTVASVLMSFGAPQTLADTVQAICLGVSYSSEVKDPARIRALVGKYPELAVVQDADRLDAIGAVGIARTFAFGGAKSRTLENTMEHFDDKLLLLEGMMKTEEGRRMAKERTERLRLMKAWWQEETSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1Z4</accession>
    <name>S0E1Z4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable laccase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_02281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428764.1">
        <property type="nucleotide sequence ID" value="XM_023573992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1Z4"/>
    <dbReference type="STRING" id="1279085.S0E1Z4"/>
    <dbReference type="GeneID" id="35395763"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02281"/>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF71">
        <property type="entry name" value="OXIDOREDUCTASE TPCJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="82"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="208"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="444"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT66683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="633" mass="71993" checksum="61162B45A64C1EFE" modified="2013-09-18" version="1">MGFWKRLTEFLFIHRFTDQTKFSHTYSPVQDLSLVDAFDAESIDGACNSPTNRKCWSTNFDIHTDYEEVIPEGKVRKFLLYVTNERIAPDGYWVDRMLFNGTYPGPTLEGNWGDTFEITVVNKLTNFNGTSIHWHGIRQLNTNWMDGVSGVTECPIPPGENFTYIWRATQYGTSWYHSHFSLQYADGLAGALKINGPTSMNYDVDLGPVLITDNFHKTTFSQVQLEYLGRPPPPDSMLMNGNGKYYCCPSLDKNCKGDSKLTSFHFEPNKTYKMSLVNTAASTHTTFWIDSHKFWVVATDFVPIEPYETDLINIAIGQRYDIIVNATAVKGKNSRNVNFWMHARDCQNGGARSNLGIIRYDATSKSIPWTPPPKEDNICYGCQDEPSKKLKPIVQRNITQHNDDYIKNSFKVHLVGYPNEFKKDSMMHKWVLANSSFYLDWAEPSLSLVKIASEKGWNNPQFPVGYEPVTLDYKNGTWVAFLIEGKFTESIHNSTTKGHRKVYKTQAPVAHPIHVHGHDFVLLDSGTEEFNPKNFTLQLENPPRRDVVLLPVDGYIIIAFQINNPGVWLMHCHIAFHASGGLALQFIESPRVIGPMFKNSGILPTYSETCANWAAYYTMFNKHNNATQEDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2P7</accession>
    <name>S0E2P7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cutinase</fullName>
            <ecNumber evidence="8">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_08003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="8"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431146.1">
        <property type="nucleotide sequence ID" value="XM_023578319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2P7"/>
    <dbReference type="STRING" id="1279085.S0E2P7"/>
    <dbReference type="GeneID" id="35401480"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08003"/>
    <dbReference type="HOGENOM" id="CLU_040058_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005146075" description="Cutinase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="262"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT69066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="346" mass="36066" checksum="4D1438BD52C00F15" modified="2013-09-18" version="1">MHSSTTLLLIAATTVNAIGIRDDCKDVHIFLAKGNNEPYPGRQGKLAGAICSGLKSCDYEDIQFQNALEDPFCDSVTEGVKNGIKQITAYNKKCPDSKLVVSGYSQGGQVVGDILGGGGGVFFQNCVEPDLQGLSPKTLPGSKIVAAMVFGDTRHTKDQPYNVLSGKGKDGLFPRPAGMLENLASYGDVFRNYCVETDPICAKGDEVETHLNYFDVFTDDVAEWVKERVGEDTTTTTAATKTSTKAKSTAKETSTKEEVESTTEAASTTKDASTVSTTKDTTTTTAAASTTVDPSSTTDTTSAQGRATAGEASSDAAAPSSTDNAATSKGASLMGMIIGVAALLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3A9</accession>
    <name>S0E3A9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Probable dynactin (150 kDa dynein-associated polypeptide) ro-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_13387</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429274.1">
        <property type="nucleotide sequence ID" value="XM_023576067.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E3A9"/>
    <dbReference type="GeneID" id="35406841"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13387"/>
    <dbReference type="HOGENOM" id="CLU_002523_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="15">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="77"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1040"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT67193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1332" mass="148385" checksum="5C86F8346BB3C13D" modified="2013-09-18" version="1">MPDFKPGQTVQLNDGSKAIVRFVGTTHFQVGEWIGVELETKTGKNDGSVQGERYFDCPMGYGMFVKPVMAKIIAQAPTPKPPARKPAARPSSFAPTSGRASSAAGDAGLGRRKSLNAPSPSPVPRVSRPTSIARSPTKSPTKQLSAASSTTVSRTGTPSNARAPSVGAKSRPSVGGPRTSMGPPPPTARTRQVSTSSGTAKAASAAPRTTTSRMSLAGPPRPASRPVSRPSSAARRTSVDSQARRGSSDRDDIASPIKDNGDILSPQPRSPVQARTKALEKLTGGPSSRTTTPPAARKPSATTTGPRPAASTAASREIEDLKAKLKVLERKRAEDRDKLKQLDKVQGERDKFESVIQMLQQKYQPQQQENAELKKLLKEAEMRLDSVEELQAEHDSILELATLDREMAEETAEVLKAELEALKEKAEEMELEVEILREENEEYSKGMAPEERATSSWLQMERTNERYREALVRLRDLTQETEEQLKGQIKGLEEDVKEFNTMKEEFSKCRGKLEQSESAVEDLRQQLDNALGAEDMIEDLTERNMSMSEQIEELKAVIDDLESLKEINDELEINHVQNEKEMQEELDFKDSVIAEQARRAAQQEESLEDMEYTLSRFRELVTSLQSDLDDMKASQAVTEGESEKLNDRSRAMMDLNMKLQISASKAQVKTIDLELRRLDAQEAEQHLEMVKLFLPDTYKEDQDSVLSLLRFRRVAFKANLLNSFIRERLNGQPHPGHEDDVFAGCDASDKLVWVSTMCDRFVNDMTHCTIEQFSKYQNALHELEPVERALNVWIDGLRRDDLKEKTCADELHRTIALLSHLGEVHISNSLANYADDLHMKAMVMQSHLDSAAISFTTVRGLVQRVVPAEGEEDELAQHFAKKSEAVVTHTRGTKVIAAKAVRALQDLRTRSLSLLPDTNEAFEQCCEATQELADLARQIGLGIHSLFTADEGRTEPFTYAEVQTAVYKTVLSVSTSSESDLFSTYLSKLRAVTTQISDLVSLATDLDQVQEFDVTPAPWRLRSQELKALKTIPVDAEEELRRLKEEHSEARRTIAQRDEHLSTAVLKIETLESRMRDAQANIDRIAKLQEELEASGQQIGSLKEDIEKQDRELKNLESERDKWKKIASDSRAYADGADAAGAKAGQERAVATAREMDALKKDIESLQSAVRYLREDNRRARTSEQYKYEWLAEPLKKPTSVAEKRRNMIAAEGKDVLGELVKMASSASLYDFSSLPQDKLAWKPVRSTPQYHAAKQMEDYASWESWQESVLKKAQVLQGQTANAERRKKTPTAARLRIKLPGVDGKVVSGSGKGVQIVGSQEWEALQGRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3E4</accession>
    <name>S0E3E4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429309.1">
        <property type="nucleotide sequence ID" value="XM_023576108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3E4"/>
    <dbReference type="STRING" id="1279085.S0E3E4"/>
    <dbReference type="GeneID" id="35406878"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13424"/>
    <dbReference type="HOGENOM" id="CLU_055844_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="395" mass="43628" checksum="23403AD7C5D5B264" modified="2013-09-18" version="1">MGLSNINPKHVTYPMRLGSDGKYLKPIFGEEEIPMFQSVTHMECFPYRYCFFVKSLPPRPWPLTVNGRPFTITPKTPEDLSLTPIRASNPKIFVGNPDLRICVNIDARQDPFQESSLRAMVRDVTEMFSSHPTYPKVMEVMLTMDQKIVILVSSDGPTGTQDSSPNRRWPGNAPKLPLFPGTSVRGSQGTGNPEGRRNAPHFAVNVSSGVLIKNQEDQHMMTTAGRIVRPGEVVGTRVFFFQNRIGLAVDVVPGTDVALVKLDDAINYKNQDGTTTFTRLLGKDPDDALPWNSIVSLATRWPPYTKGIIVAKSVRVVRHTATTHYRVYHWAWTGQPGNEKGPNPAPRDPMIGAAAISETGVVTGLLHSNEHGLRAGYSIMLSASELVYVGYSLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5K1</accession>
    <name>S0E5K1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_05910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCT69980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023579175.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="35399388"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05910"/>
    <dbReference type="HOGENOM" id="CLU_001040_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PH_Osh1p_Osh2p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Oxysterol binding protein (Osh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000008">
        <property type="entry name" value="Oxysterol binding protein (Osh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000061">
        <property type="entry name" value="Oxysterol binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
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        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="419"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="781"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="731"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="542"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT69980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1307" mass="145028" checksum="50264DAF89FD75AF" modified="2013-09-18" version="1">MSDAGDGTKRAAALSDWLAITAAYARTPDAVDAMESQLGHITHASLSTHKRSKSAAALSLLRRNNTRDEESGSEDGRLRRTPSSSNPINPMAHQQTPRGHGAKQSVSSAGLSPTASQSKSQQFLSSPSAEKSTASLEQSVRKFRFVEALRSGDTSSISRAIRETAENAPRASISSVGASATSALDDTTILHLAIQCAEFPVIEYVLSEGQGSIDVNARDKDGNTPLHLAAIQGRTTVVKLLLEQKDINDAIANAQGKLPLDVARNPEIFQLLQLSRSLFAEAKVKQVQELIARGNYGALAGVLEEHRVKTVLDINSPEFASEPFTVQTGGTLLHEAARKKNTNLIQVLLLHGADPFRRDRKGKLPQSVTNDDATKAILKKSPAAVAAQRGIQEKAVLGQAASQGTAGSASGDPLAGREAREMKGYLKKWTNYRKGYQLRWFVLEDGVLSYYKHQDDAGSACRGAINMRIAKLHMSPDEKTKFEIHGKSSVKYTLKANHEVEAKRWFWALNNSIQWSKDQAKEEEKRAARGAELLRQAKADPSTLSLQDSYSENTSVTDLRRNSSQLPSRSLSKISSVDQRPSHTSPGTTGSFEEDEFVDVETDAGTSRAPRNGAPTHNDMDDDDDYGDDMSIHEEPTATKDALNITAQSAKLQLETMSHVHQALLNELNQNPNTPLSDNSVTQALGTYDAAIRSLSTLVADLLRISKDRDAYWQYRLDREANMRRMWEESMAQVAREQEVLEARVGEAEKRRKATKRALREVIESGIPVGVEEAMPRVEDTITEKELSDDREKEDEEGKFEDAATKLSPVPPKSPTMKSVRRKPTIIVDLSESESEEEDEFFDAVDAGQVEVSELPAEEVKPKSQDIVVSGGLDISSSFKGYENGIRTRLKMDADDRPKISLWGILKSMIGKDMTKMTLPVSFNEPTSLLYRAGEDMEYADLLDLAADRADSIERLIYVAAFAASEYASTIGRVAKPFNPLLGETFEYVRPDKNYRFFIEQVSHHPPVGAAYAESPKWSYWGESAVKSKFYGKSFDINPLGTWFLKLRPTAGGKEELYTWKKVTSSVIGIITGNPTVDNYGVMEIKNWTTGEVAHVEFKPRGWKASSAYQVSGKVTDATGKVRVSLGGRWNSKLYARLTPGYEAAVDEPKESGGDMAQGGLTDPNRAYLIWKANERPTGIPFNLTPFVLTFNHIDDKLRPWLPPTDSRLRPDQRAMEDGEYDFAADEKNRLENAQRARRRLREERGDEFVPAWFRKARCEITGEEYWQFTGKYWERREKAGPNGDPQVAWEGLEPIYEDHVDEDTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E602</accession>
    <name>S0E602_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to meiotically up-regulated gene 72 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023579474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E602"/>
    <dbReference type="STRING" id="1279085.S0E602"/>
    <dbReference type="GeneID" id="35399654"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06177"/>
    <dbReference type="HOGENOM" id="CLU_021479_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000424">
        <property type="entry name" value="Meiotically up-regulated gene 72 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="199"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT70226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="745" mass="80727" checksum="3DABCD819655E650" modified="2013-09-18" version="1">MASSELMSVCSVGGNPVSAFLSWRLQATNACDVTLVWKSGYEHVAQYGISFKSPIFGNERFKPRHVVRNPEDAASARDGPFDYVVLCVKALPDVYDLASVIDSVVTPQHTCIIVNTTHTLGVEAALEERFPTNVVLSLVSGAELTQLGQSEFEHKGPADIWIGPANNPNNIPQTIQEDMAQALAMTLSSGQVECKVSPNIRQQQYERVIGPIAFHPISVIFETPSHASLLEKVGVRDMVSEVIDELLRLADANGCKFDPNFKQKTIDEMSKASGESIMWQDYVARRPMEVETYLGSPVKLARDSNISLPRIETLYSILHNLNLVNRSRPKPGDPNANIIPPASPSAAPVPRMPSQNSHRPMMNGMPNGNGMPPRQPRPRNSSNFSQGGMRRGPPPMNGGPPNGYGRPPPMNGPGSRQASRRGSLEETNLEEFSHLVLYDDIPEGSEPSVSGDPADINLRERELALRQREMAIREQEIRMRRGPPPGPPGGPGPRRGPHPMRNSKQVFDEDDDDDDDYFDPTANPGPPLIDPDNFDMMSVTSRKNRKAPGPSPGQFRRNPDDMPPPTRGGRFRPNFGRNRSSQVGHSSMTSENILEDPPNSLTASRLDEMQYGPGPGGPPGMNGAYPRRASQSPGNPYTPSMRGGSRRGSPPGGYGPGPGMNGRPSPPDGVRQPVPRHPPGHGNSVAPQQVEQHIGVSALHQTKPRNVRSLTGSASASAGSGEFDSEQSANSSQGSLPPRPPIGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E609</accession>
    <name>S0E609_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432199.1">
        <property type="nucleotide sequence ID" value="XM_023579344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E609"/>
    <dbReference type="STRING" id="1279085.S0E609"/>
    <dbReference type="GeneID" id="35399539"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06061"/>
    <dbReference type="HOGENOM" id="CLU_1094361_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="255" mass="28654" checksum="AA6CDD129BAEA0D3" modified="2013-09-18" version="1">MMAKPWNEYQGTITKLYIKDGRTLKDVRAIMKLKYNFDASIRSYRQHFDIWGVGKYTCKKREERRRRSVNNGLSLSPSQSLADVIIKQEDASSPTSSSGSSSVSRRSSEQKPLPVLKQPILYPSFFQDQMRSQDDAQAKIDAPRAPLWEGLDIDSLRGSQTAQAMLPSIMPIQSYNEASSWPVPRGSSSYLNSPPQSFDRPHFESMVPRYVPDQPLYPRDAGLRSGLRAPDLSVGRPNPGDLLHHMVGYHGVAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E613</accession>
    <name>S0E613_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432320.1">
        <property type="nucleotide sequence ID" value="XM_023579491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E613"/>
    <dbReference type="GeneID" id="35399670"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06193"/>
    <dbReference type="HOGENOM" id="CLU_104710_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="224" mass="25639" checksum="E9A96466B2BF148A" modified="2013-09-18" version="1">MAHGVADIDGWVRMPYLISTAQNQFYENYPEQAFRTGRNLNRPDICWETTSSRSLSDWSCDPGGPCCTCDCDCQPAPRLNAQPVGYFCKPQDNASVPDGTHSHSHGGGQGPPGPFDAHYQPNTYHSYMREPRVLYGKQEVSSVEDMIYYSAKEQRYKNDAERRIQDWIRLMPELVGNSKTSSSTHGMSKRYTRNNNNTEDKKKEKNKGDGSKRKKRYPFTRRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E661</accession>
    <name>S0E661_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to LSB5-possible role in the regulation of actin cytoskeletal organization</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_06124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432254.1">
        <property type="nucleotide sequence ID" value="XM_023579413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E661"/>
    <dbReference type="STRING" id="1279085.S0E661"/>
    <dbReference type="GeneID" id="35399601"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06124"/>
    <dbReference type="HOGENOM" id="CLU_036827_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
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    </dbReference>
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        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="5">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="6">
        <location>
            <begin position="236"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
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        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="435" mass="48527" checksum="6B3F970A25FF00A5" modified="2013-09-18" version="1">MSMFQSKKPFSAVTVTVENLTSESYEEEDLSGIPELVEVITLQATGPSEAARAIRKKLKYGNVHRQIRALVILDGLIQNAGERFQRTFVDEPLLERLRVCGTSDLSDVAVRNKCRELFRSWSQYAGRPGLDSLARLHRELPKRKQAVTQERSRVLRETEENPFVDDEQEAAAKAARDARDASGPSSSNPAYGSTFGHSSTKSSSGPSAFFGSSKDKKKEKEKDKAKGKRKPFNLEAEKEQMKSVIADSSIAATNLMNALQSINREVERISENQTAVERFEACKLLRRKVLRYVHHVEEEQWLGGLLHANDELVHALMSFEQFDRSIDADSDSDDELAEQAHLYRMATIKGKEAMAKAASQSPTVSQPPDLSELNISTPVHAAPPRPPPMSKPHSNPPPQPPRPVAAPQDEDDEDDPFGDSHALETPMHERDQPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6Y3</accession>
    <name>S0E6Y3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431577.1">
        <property type="nucleotide sequence ID" value="XM_023578593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6Y3"/>
    <dbReference type="GeneID" id="35398867"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05388"/>
    <dbReference type="HOGENOM" id="CLU_1686737_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="156" mass="16974" checksum="CE19D44B8ABB43B4" modified="2013-09-18" version="1">MPQDNEFMTIYDTRTVIIRATKTMRVTGTLSTFIHVFSTSSKTTLATKTTAITRTSTERVTKSLTATYWSLQTLSTTVTETNKYVVTKTLITTRIVTRTVPITEVYTVTFTGINAVTEAVGSTVTVTHATIQTVLFTITASVSAITATAEATTIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7I7</accession>
    <name>S0E7I7_GIBF5</name>
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        <submittedName>
            <fullName evidence="8">Related to transport protein YPL264C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_06599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023579942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7I7"/>
    <dbReference type="STRING" id="1279085.S0E7I7"/>
    <dbReference type="GeneID" id="35400076"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06599"/>
    <dbReference type="HOGENOM" id="CLU_032828_4_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="59"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="241"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT70610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="396" mass="43417" checksum="661CF7979A56CE76" modified="2013-09-18" version="1">MSYSQSKTQANQHGESEASSLLAPAANREDSSSETSSETSSDSDSTILERLQSFYSRNIGLFYVLVAQLFASIMSMTTRLLETGFETKFHALQIIFVRMLATALIGSVYMWCKNVPNFPLGPKEVRGLLVLRGFAGSAGLFGLYYSLSYLDISDATVITFLVPTLTAFIAWVALREPFTVKEATAGFIAFAGVLFVARPAFLFPESWRTLSELESRAVDPDFTTDGGILPPVKATPQERTIAILCAIFGSFAAATAYATIRVIGKRAHSLVSVNYFAVLATVSSFLIIMIHPNLQFEIPKTIAEWCLLLSIGISGFLLQLLLTEGLQREKAGRATNLIYVQMVFALIIERIVWGTTPPITSFIGSALIIGSAIWVSLQKKAPADPRPLLDEERRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7M2</accession>
    <name>S0E7M2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4419 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432729.1">
        <property type="nucleotide sequence ID" value="XM_023579987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7M2"/>
    <dbReference type="STRING" id="1279085.S0E7M2"/>
    <dbReference type="GeneID" id="35400116"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06639"/>
    <dbReference type="HOGENOM" id="CLU_037155_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50673" checksum="1EA06F8BD21645AC" modified="2013-09-18" version="1">MPVIIRPSGNAPRLIKAYEFRKIDRRWQFDDMCPKEEEKVKCIIQSSFDSETDIISATNGFVLGALKAYSKHHHLILRPDDIWLAILTQLSFFINRNADALRHLFVAHNKKKCLSVISPEMLKKQDMGAMAKVLAEGMGQNMKDKSLHKWIIPDFTTTTDTDVVAASVVMAGAFRSYFNYSFSYYCGMPSITLLGTKEDWSNLGTRLDGLTTLTNGLPPDSQPSEELHHFHQLLVPVLNRMARTFDDPTDPEIVDFWSRMVHESRGSGVHYISGWLTAFCFWSSKGDALYYEPQEAVDISSSDKTRPGCVLDNVRYHRTDTDVIPIGWASAPIDVDDNGFVYKAMMIAGSMGMKVSSSGEKLDRTGRYCDTISADSDGRHVVTEKGEISTVTFKRTDEDDLETGPDTLQPVIGWWMYEIATQKSEGDEYWEAESEKDWIPAGLVALLSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7Q5</accession>
    <name>S0E7Q5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432980.1">
        <property type="nucleotide sequence ID" value="XM_023580154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7Q5"/>
    <dbReference type="STRING" id="1279085.S0E7Q5"/>
    <dbReference type="GeneID" id="35402549"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09075"/>
    <dbReference type="HOGENOM" id="CLU_1304958_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484945" evidence="2">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="211" mass="20598" checksum="1CDF6AA176221D1B" modified="2013-09-18" version="1">MKHWSLFCLAYLLNGDMALGSKLPANCATTTVLSVITTTMCSAGSPAVPTALMTGGNGNVPEQYSQPASASSVTPGSGPHVSVSHGSAESPSAGTNENTAKESDAPQAGAGSHAGEASGATQAVKPTTVPAVGAGASASNGSSEPNHIASGQASSVTGQHSTGTGTTSETSETPEVPVVASGASSSESNVRGNAIIMAGILTCFVPMMIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7X3</accession>
    <name>S0E7X3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430613.1">
        <property type="nucleotide sequence ID" value="XM_023577559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7X3"/>
    <dbReference type="STRING" id="1279085.S0E7X3"/>
    <dbReference type="GeneID" id="35400798"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07321"/>
    <dbReference type="HOGENOM" id="CLU_044590_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052350">
        <property type="entry name" value="Metallo-dep_Lactonases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569">
        <property type="entry name" value="AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569:SF2">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="117"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="346" mass="38902" checksum="4F0AC8CB233388B5" modified="2013-09-18" version="1">MSDEQIILPIIDSHIHLYPAAETDSLAWYTPDGPLAGQHSLEEYREATSSAPSLLGFVFVETDRKNDVESGAIDGSGWEQPLAEVSWLKRVALGQPREGEGHSPEDAKLCLGIVPWAPLPSGPEVLERYLDRVKEEAGDAWPKIKGFRYLLQDKPHGTMLDDKFIEGVKLLGRRGFTFDVGIDQHRRGKKQLDEVIEFVDRVHDGVPEEEKVTLVLNHLCKPDFSIYNLTSDPSFHAWRTAVYTLSKDSHVYMKLSGGFSEMPDSLRNQDPNHIFEATLAWLGIVLATFGPSRIMFGSDWPVCTANTDNAWPRWRSIVERMCWMATLSDEERAMIFGGTAKKAYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7Z0</accession>
    <name>S0E7Z0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431987.1">
        <property type="nucleotide sequence ID" value="XM_023579088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7Z0"/>
    <dbReference type="GeneID" id="35399310"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05831"/>
    <dbReference type="HOGENOM" id="CLU_2399850_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="93" mass="9830" checksum="5D0C94AD28FFA30C" modified="2013-09-18" version="1">MATPIVTLSEEDESWMQWDPSVETVWPDVAAPSPLPMPKLPAPIVEKPSGENYKPGLTPATTDRDDRLSSKGGKGNRGARAISLENGGGATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E821</accession>
    <name>S0E821_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432884.1">
        <property type="nucleotide sequence ID" value="XM_023578981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E821"/>
    <dbReference type="STRING" id="1279085.S0E821"/>
    <dbReference type="GeneID" id="35399215"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05736"/>
    <dbReference type="HOGENOM" id="CLU_020995_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485675" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="67905" checksum="B439FB426E536CAC" modified="2013-09-18" version="1">MRSHLFTGLLSSLATRTYSLDTSTPGMDSEPNVNGYSDKKMVECATICSRELMHYHGIPTVEGLCHDMAVQREMFSCLASSCTDQYGQALTYTISTCSHRGATISDLLPVEIQHTSLATRHLVPLVSRSDSASFGFESRFSLTVDCKAGSDGVLTLSLPESTASVPQPIPDGGSPTSPGAGNGNTNAGAGPPGGAPGSNHGPLLGNTAGSSDGQDSPSGGPSSGGGGGNDGTEPSDPNTDCEENNFNNGPSPSGSDDGQYPPAPAPAPAPVPVNPPANSNPQPDGQSKSPPAPGPDAADGNSSPDDPHQGNTAQSQPQSAPAPVPAPSNPDGSDGAPNQDGTSGPGEDCDENSPNGSDANSTGNNAAPVSPPNTGGSVDCSIDINNPACANQNQLSPGPLAPQQPQIPAPAPDSPTPQGPLPSPGPAPAGDNPPCGAEDGITDCPASRQPPKGDGSGGNACSDPDSNAGCGSSEPSSPQPPPQTAHPALPNNCPGDENSPCNDGNDGGSDPGSSSLPANPPSPNSPDVPPLDVGPSPVAPPSQPNTDGNPDNGASCAGKPGPCPANGGPGISEPANPPSPAYSPSTPPKVKPLTVLKIMTVLDGKAPAKEVTMVMAGKGTVISDPKHQKSQHHLHNPLCLHQQFQPSFQDLQFNQDPLNLPLPTLWAALKRDLKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8F8</accession>
    <name>S0E8F8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_07576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430843.1">
        <property type="nucleotide sequence ID" value="XM_023577844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8F8"/>
    <dbReference type="STRING" id="1279085.S0E8F8"/>
    <dbReference type="GeneID" id="35401053"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07576"/>
    <dbReference type="HOGENOM" id="CLU_051214_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="4">
        <location>
            <begin position="89"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT68763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="343" mass="37920" checksum="CEC3AB7C833F9102" modified="2013-09-18" version="1">MATNAAEDATSEKPHVAKAKRSWPLWKKLTAFSVTLSVIIALAVGLGVGLTRGKGGSNSDDTANSETDDSTEPYLKARSSLWQPKVGAQWQIVLLKPIKLNKAGSAKDLKPNVGIYDLDLYDNDAETFVALHKAGKKVICYFSAGSWEDWRDDKNQFNKADLGKTLDGWPDEKWLNLRSTNVRNIMKKRIKLAAQKGCDAIDPDNVDGYQNDNGLKLTKKDSIDYIKFLAAEAAKYNMSTGLKNAGDIISSVLPYVQFSVNEQCVEYSECETFAKFIKAKKPVFNIEYPKGAPKVKESDRKAICSKKGKAKGTEGFSTVIKKMNLDGWVMYCTGNTYQTAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8K8</accession>
    <name>S0E8K8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433310.1">
        <property type="nucleotide sequence ID" value="XM_023580552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8K8"/>
    <dbReference type="GeneID" id="35402191"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08715"/>
    <dbReference type="HOGENOM" id="CLU_123978_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="142" mass="15599" checksum="2BDA55AD8FAB64C6" modified="2013-09-18" version="1">MASNTISQLPTAEQRQDITARLADLITAIESHAQWTPPNVDRGLFHVWDFVKRSHYIMTELDNIAAGRKVQHPEQIPKNEGVASGPEAALASYTDVCTRTITINEMIQNPRMLVMLGLSNVDFGAAIQEKSAAVKEAIKSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA83</accession>
    <name>S0EA83_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to acyl-CoA transferases/carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433873.1">
        <property type="nucleotide sequence ID" value="XM_023581236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA83"/>
    <dbReference type="STRING" id="1279085.S0EA83"/>
    <dbReference type="GeneID" id="35401578"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08101"/>
    <dbReference type="HOGENOM" id="CLU_021588_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="555" mass="60945" checksum="EDD50A9C22A1A568" modified="2013-09-18" version="1">MSNHGTTRDTYGPGTFADADYLPLVPECHRLLKYFSNVTPGFTQIHLGHVRFHGQELPILPGPLKSQAMAAVFQAMIGLVGKEISELRDIETGSISIDADKAGLYPATPAILSIDGRTLAQIQKDGTLLRAGKDLDRRVLTKNDMHFRSWAIYPTKDPQVWYQIMGNLDPAGFLRAYGLDPTLETSSRTEAYEIIKAEMVKYSAAELEQKNMEHGFCGQTCYSPAQWRETSMGKSLDKYPVVNYRRTNLGSSLPPVPFSTSQTDLRPLAGIKVVELARVIAGPAMGAALAALGADVIKALSVSLTAGKRTYSLDLKVESDRQKLHELIGDADVIIQAFRLRSLERKGFGLDDVLRMAERRGKGIVYVDLNCYGPDGYYAERPGFQQIADAASGCSYVCGRAYGFEPGTSVLPPLPIADMLAGAVGVIDTMLALRDRAKSGGSYHATVALTAIDAVQLKQEVGLYSPKNVKKIQDTYKFAPMTPDLHVEELLYILSDSWAKHSDILNRGYMVEFETVWGKSHNILSPIVQYENGSVSPRWTHGPVPYCSSENVAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAC7</accession>
    <name>S0EAC7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to RNA binding protein Nrd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433950.1">
        <property type="nucleotide sequence ID" value="XM_023580754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAC7"/>
    <dbReference type="STRING" id="1279085.S0EAC7"/>
    <dbReference type="GeneID" id="35402010"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08534"/>
    <dbReference type="HOGENOM" id="CLU_043434_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12261">
        <property type="entry name" value="RRM1_3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="388" mass="43554" checksum="9557500F86D0A08B" modified="2013-09-18" version="1">MSINMRMSMNKTQKQDGLDMPVSDPQCVYVPQEEYQSLLTIAHQYVYLRQNLIAQGLNEATVDSLCLQKSAGHAPPYAPEQFEPSPPATLTYKEQASPFPVQSNTASGCPDEEQGLRFNRSWQPNASYRPSTYPGGSINRKGPGYFHDNKRPEIKEWFERSAQRSVLLLNVPDGVTHGDVAAVIRGGPVLEIFLRGKDNTATVSFLHGADACAFIENCRTDGLYIKDRKIHTKWSDYQFTLSGQVAHHIRKGGSRNFVIRKRDPNLTIQAIRGDLEHIHNLHVISIEFEKDSCFISTNAVHGAIYARTCLQSRVEYRASRIEWYADECAQPFERTSPAFQDPVPDVKSQRSVIAAHPSRKDLMGNRFQLLDLSDSDGSNGDDSSDDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAY9</accession>
    <name>S0EAY9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434149.1">
        <property type="nucleotide sequence ID" value="XM_023581454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAY9"/>
    <dbReference type="STRING" id="1279085.S0EAY9"/>
    <dbReference type="GeneID" id="35407385"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13931"/>
    <dbReference type="HOGENOM" id="CLU_411656_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="802" mass="91017" checksum="9525B6DCD463C784" modified="2013-09-18" version="1">MQLLRGDRGDTSSTSSRSYGGFGASEPRLFEFSERGRSVAPKCIEMSKQHPEEFLNYLQQAWKRDKIYAKENPDSMFDIKAIRVLCQDGKFRPLGNSYIPLPKLHYLRNRYMLEGEPFPFLRLDPPIRSEGGFGQWRCLRAFAKYHDDLDFFLEMLVRIRRTKASTVEFPRRILELYLRIQAECEDSKDPAASQQKVRNTFEKEQLVYIHPIWRPLSECLLEDTCEISSTLSKSPVFPVPSDWDASKSELVSLREFYTQTLRLQNASYRTIVDVLEKRDFDAELDPADLWLTDELYRALDKMRLDLSPDDAADLKLAFAEKAIIAIAPGEAVTWLNAADCTWSPKLESPEINDLSKHYPELHDFFVNFLDVKQNDSGLIFDTLMNVSSLSPDCSRDNTARGLLVAVSQRIPEFGHIFDKERFARSNVFPVSTADGVLLCASTMEFSVADRQNLKEAFTGKLNLLDFDPKTVWMLDNLLVWAGLDSRYLSKHVEDQGPADENFKSIELPYELSSKADQLLRIAVHFKSPRTSTPKATSWLRETLEHSEVRLASGFQSQLIYRSGSAFITAVNPMGGLDIKDTVGFTVYADDENWEILKQTVLPRRLLEWIMTDPETNVTGSVPEQAVSLVRSILNIPVGREHVVPKILDAEGIVDLELLEASPYWRVNSERVPDTTITTKSDKLRPAKILDDEDDEPSPAYTQGESYHAREGLADSKSSPPPGMPTYAEPGLTTKINSAERGMTTKAGDLTKDTKQDALRDRLPISKRGLERRHSEKSAWEEEFVANEATLIDFSGEDVYGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB83</accession>
    <name>S0EB83_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipid droplet-associated hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_13815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434259.1">
        <property type="nucleotide sequence ID" value="XM_023581582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB83"/>
    <dbReference type="STRING" id="1279085.S0EB83"/>
    <dbReference type="GeneID" id="35407269"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13815"/>
    <dbReference type="HOGENOM" id="CLU_018394_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35727" checksum="07276E34D3C00593" modified="2013-09-18" version="1">MASQTWLPSERSGNVQQKALIHYICGNPGLIDYYTDFLSHVRGLLDKIETDTAYDIYGTNLLGFSDDDHEPFSSKNKPWDLEGQIEGMYEIVAAKGKGYDFVILMGHSVGSFITVEIFHRHMKNPERAPHLKLRHGFLICPTLTHLARSSNGVQFELLRRFIPFLDTAACLLARLLLGLLSVASVTWIVQRLLAFTPASADITARWLKSRDGVLQAVHLGLTELEMITEEKWNDDLWDTAGEDNGVPKFFLFYAKKDHWIHDDERDGIVEKRGDKARIVQDEGDIPHAFCTREDASLEVARRVCGWVEEIEAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBK9</accession>
    <name>S0EBK9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434093.1">
        <property type="nucleotide sequence ID" value="XM_023581387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBK9"/>
    <dbReference type="STRING" id="1279085.S0EBK9"/>
    <dbReference type="GeneID" id="35407444"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13990"/>
    <dbReference type="HOGENOM" id="CLU_013511_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016864">
        <property type="entry name" value="UCP028035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028035">
        <property type="entry name" value="UCP028035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="9"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="950" mass="108089" checksum="D4ACFEE6360C371F" modified="2013-09-18" version="1">MVSQNLYLSYKRDTKYLLYWMINVSNRLLRSTNGEAQSAASVNTTGQTTVNGLISMSTLISQHKEPVPNVIYWLFESIIQARSLVSTTFQELMGPDSDEELKRSNESHRHFINTLHSAFRILGGEEWEKTSATTSDDTEDVKQILFANKFQELSVDKEESSDEEDDVVQPHSPVAARKVSRKPKGKGKKARKYKKPKKGKKQDTLDPATDEIPIESIRIIEDSGEVGLVTDYLLAVYSTVKEWAALRAYNQSLWKEVAYEGLNSAVAGAVSNLTISMVKRTNAAIFVDFPGHDTYKIIMNTITRGNMERAQENFRLALFAVGPDGEHQSRKETAVDIKEQFLIHAYQDLRDFVLDFQANRTGKPTKAMQAKLVKWDPNFNLERATNEERVHWRRCYTIKWLYDLVNVFSSVVVQRNTVRGEKHVYEDVDWSANGPWGVHRVLFGLEEFAGDITNMAMKKPGTDITKMIYPHHVFQMQCIVDSFTVSRGWTLSALYGHMLEAPAKKGRARRDVDLFLDRQNKRVFAGYCQTVDLLKQILEKDGKMEQHKDFFEIIKIAQLDFVDFLGEHKYTTGLDTIPPSRFADHDANGLQEYSPFLCGVGLEEGLEIAYRLGIFLWESMPEPTLMIHLHNAVVQKGYLSRPIGLCATLEDLFKHTFFAQGHKPTSGFVDALLASVGQPGSRQAQAQRQAIRYRRRYAENIHQLFDLEINHIFKRHSMLTTCRRAGWDLEAIPDEELQFGSMLFFERLSRAKLLSENKLEYTVLVRKARAVGMTDEEIIDATNKLSSIANNTLEVPNEVLNKYAPEGFQIPPQARSEVLDGRDILDLAKFDILSDVAGIAPISSLNYLGVTCWLLITFGRIEEQLKEAGNPVYFEAYEGSGPWKLEKRVALALLALKGDNEESLRIVADTLNEARSGFMDFIYWEDLETEPRERESHHVDPSVGNECTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBM6</accession>
    <name>S0EBM6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434429.1">
        <property type="nucleotide sequence ID" value="XM_023581790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBM6"/>
    <dbReference type="STRING" id="1279085.S0EBM6"/>
    <dbReference type="GeneID" id="35405667"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12211"/>
    <dbReference type="HOGENOM" id="CLU_030082_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="405" mass="44945" checksum="1C4FFDEC77D45FCB" modified="2013-09-18" version="1">MDLDIEMDDAVDTVHDAPILDIGRDDILQPDEPEEPGEVAEDEPPTDDSKTLVPTKIHIKGVDSLHTTDIKAYVKAHFSDVDRIEWIDDSSANLIFPSEPTARDAIVALSSVPVADATALAIGETLPAKPLEGKPEISLQVRFAVQSDKKEVGAALRSRYYLLHPEHDPEERRRTNQENRSRYRDRDDGYHRGGEGRRRRASDDDVETFEASMYDDAPRPTRRRRDSDIEERPRSYARENQGKELFSGRKTQRDRSASPRRDNDGDDLMGERASSSGNRARARDLKDRISGSNNSKELFPTKKSIKQFGGGNLDTLERAIGSARLKDEDRPKIVSVPSARGDGNSFNIRGMASQQGSGEGFAIKGAASANARELFPTKLGSNNTGKELFGGGRSKQRQKAEDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBY7</accession>
    <name>S0EBY7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_05842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431998.1">
        <property type="nucleotide sequence ID" value="XM_023579100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBY7"/>
    <dbReference type="STRING" id="1279085.S0EBY7"/>
    <dbReference type="GeneID" id="35399321"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05842"/>
    <dbReference type="HOGENOM" id="CLU_004620_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="62"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="537"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="868"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT69918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1048" mass="114520" checksum="974F217BDF9147CB" modified="2013-09-18" version="1">MSATRIGQRLARQSRRAPFTLQPRLTQSIRLTGVSRAFSVTASAPRFVDTQSKLQDHELFSRRHIGSESSEQAEMLKVLDPPVNSMEEFLEQTIPPQVRRKQKGLNLVEQWYEGGEEAAVPPNGRTEHYIQQEMRKLAKNNKVYESFIGAGYYGTLVPAVIQRNVLENPAWYTSYTPYQAEISQGRLQSLLNFQTLITDLTGLDIANASVLDEATAAAEAMTMSMANAPKGKGQKVFVVSKDCHPQTIAVLQSRAEGFGIKLVIGDVLADNSKLVREVEGDLIGTLIQYPDTHGGVHDYQALADIVHEKKALLSASTDLLALTMLKPPGEFGADIAIGNSQRFGVPLGYGGPHAAFFATSEKYKRKIPGRLVGVSKDRLGKPALRLALQTREQHIRREKATSNICTAQALLANMSAFYAVYHGPKGLKTIAEDIWSKTRLAQNLILEKGEFKLHTEGLREDGAVLFDTVTLKGSPEAIAKVHKNAESQNINLRRVAEDKVGFSLHEGVTLESLGNLVKAFGVSEAEFKSALESDKATFLNDQIPASLQRKTGYLEQPVFNQYHTETELLRYIYHLQSKDVSLVHSMIPLGSCTMKLNATTEMLPVSDPGINNIHPFAPVEQASGYQALISSLAKNLSEITGMDATTLQPNSGAQGEFAGLRCIKAYHEARDGDKRKVCLIPVSAHGTNPASAAMAGMKVVTVKCDGKTGNLDIEDLKAKCAKHADELAAIMVTYPSTFGVFEPEIKQVCDLVHEHGGLVYMDGANMNAQIGLCSPGDIGADVCHLNLHKTFCIPHGGGGPGVGPIAVKKHLAPYLPGHPEIDPQRIGAERDSTAVAPISAAPWGSASILPISHTYILMMGGDGLTKQTGTALLNANYIMSRLLPHYKVVYTNANGRCAHEFILDVRPFKETAGVEVADIAKRLADYGFHSPTMSFPVSGTLMIEPTESESRAELDRFCDALIQIRQEIADVESGKVPRKNNLLTNAPHPQEDLLSSEWDRPYTREEAAYPLPWLREKKMWPSVGRVDDAYGDTNLFCTCPPVEGSENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC09</accession>
    <name>S0EC09_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434233.1">
        <property type="nucleotide sequence ID" value="XM_023581549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC09"/>
    <dbReference type="GeneID" id="35407298"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13844"/>
    <dbReference type="HOGENOM" id="CLU_096155_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="200" mass="21655" checksum="DAD0661ADB0E027A" modified="2013-09-18" version="1">MCHGHPRHHPCAHTSINWHYCPSALIDLETGYETPCSNISFAAAQPTTSDCPLQNCEFKSKGGSWTCCSCQQGPNTQGWCTMPMSRMTMNPESFSVESVETTCDHGCCSKCVQYGSSRDASPEMTFSEIRKGSASRKFGYSSATKSHRRGSAFSLPASGEESTPSPSTSKSSSASSGYKVGMEYTSGKAKSSKKRHKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC68</accession>
    <name>S0EC68_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_13756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434313.1">
        <property type="nucleotide sequence ID" value="XM_023581647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC68"/>
    <dbReference type="STRING" id="1279085.S0EC68"/>
    <dbReference type="GeneID" id="35407210"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13756"/>
    <dbReference type="HOGENOM" id="CLU_1749806_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16655" checksum="9EC24FEC6D06E9D5" modified="2013-09-18" version="1">MKKLAQVVAYMHTSDIRPLVTDGVSEVFVRGVSTKFDDCSYILLDPEQVAHLERNLRADTWQLGCCFALVLGVAMREYEHSKKSLKALCDEGSSKGEALSNQLAYELVSGMLDKNHETRLEIHQVLSQIDQFVAQMNTAVVGDVDMSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECV5</accession>
    <name>S0ECV5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434787.1">
        <property type="nucleotide sequence ID" value="XM_023582226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECV5"/>
    <dbReference type="STRING" id="1279085.S0ECV5"/>
    <dbReference type="GeneID" id="35406058"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12602"/>
    <dbReference type="HOGENOM" id="CLU_015493_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54723" checksum="6A26EF478BFAEED8" modified="2013-09-18" version="1">MTYSMVVFKLTSVGRKIGCDRATPSCNNCIRTQRKCLGYGLQLLWPDRHDGRRRKRDPAEHRPPATPSGSVYYGKYFLNTSMSDIDIAFTNSGGHMLVDLFRQRPRRSLTLHGPLLDRAGMLLGYYQNIISPMISTTQAQNGFCSTLLPMALSSQDNSALALLNAMIAVAMIHYSNSIADAMSFKLKAVRNLSISLASSTRSKCASTNQVQLAAVMMLCVYDVFDREEHNWHIHLNGAKEIIRRQCTDTPGSSSDFLLTWWLYHDVLAAFNYPSWRLNESPGSVSTSALCAFSGDKFLIVGSLGCSVEVLEIIDEINMMRLHSAQDCLSTSTLQRCDLAMKLYNLRQLVAPIECSDSLRSHRILAIAELYRLAALLYLQRVHSIAEDDFTRPAYVQQALGILKSLDVATSPWPVFIIACEVDEQDRVSILHTLDRMDSVRSIGNIKVLRDIIKGIWKQQDLRSIGKACQRVDWLQFVEGDVPVPWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED98</accession>
    <name>S0ED98_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_12454</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434653.1">
        <property type="nucleotide sequence ID" value="XM_023582062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED98"/>
    <dbReference type="STRING" id="1279085.S0ED98"/>
    <dbReference type="GeneID" id="35405910"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12454"/>
    <dbReference type="HOGENOM" id="CLU_010194_5_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT72575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="298" mass="33185" checksum="8C51C56BB678E0B9" modified="2013-09-18" version="1">MITNFFRFLLGVISTISICFIINKILNRIILYTSSTAQPWDWSKEIVLITGGSGGIGSEMVNKFSRRNITVISFDIHPPKSTLSTNAHFYKVDVTSPHGIHEAMEQVRREIGDPTVLINNAGIALGKDILACAADQIKQMVEVNLLAHFWLVQELLPSMIKQKHGHVVTIASVASFITIASNIDYSCTKAGLVAFHEGLTQDLKHRYNARDVLTSIVFPYWVRTPLIQNLTTHSTFQDPLQEPKEAAEAIVDHVLKGHRGDLFLPGYAGLLCGIRGFPAWMQETIRDSKASVLRETSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDA7</accession>
    <name>S0EDA7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_12818</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434999.1">
        <property type="nucleotide sequence ID" value="XM_023582469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDA7"/>
    <dbReference type="STRING" id="1279085.S0EDA7"/>
    <dbReference type="GeneID" id="35406274"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12818"/>
    <dbReference type="HOGENOM" id="CLU_010365_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="250"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT72921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="545" mass="60913" checksum="DD324555BD9557F5" modified="2013-09-18" version="1">MEGVKPPSTKQDKNEEALTKYAAFLCGLMLLVIAIRWLRNNHITSPHLKTSASLPTYGREACFLVFQSLERRLPDSWFGRPSLGFILMISVYLIGNVAFCSNMLAMPQLLNHWASRFGWMCAGNMGLCVFFGLKNTPLGLFASVSHSQLNILHRFVGYTTVFLLALHALVYTIHFGRQGRLVQLLKKEDLEGMGAGIAMLVLLMGVFRHKHYELFYASHVIGFVAVVLLTALHRPIWAKKIPTVMLIIFSVWAVDRLIRLSKLFRNLVNNSATVYPLPYNGTRIVLKKPGMENSLPGFHCFLWIPGLRLIETHPFTIVSNDSSGLELVMKSHEGFTKAVDSFASRNPRTSLWASIDGPYGSLPDVNNYDKLILIAGGSGAAFTFGVINRIMMQREKPAIQSIEFVWAVRRIEQLSWFRRHLGNLTESPYPINLKIYVTGERSASGSLRDDIDTPESSWGTEREILLREDAFDYETISAMDDLCVSACGGVDNELKSSSFLEKLDVDGTIRKAAQASGSHDRVLVLSCGPKSLMEAVQDSCRVETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDQ1</accession>
    <name>S0EDQ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434858.1">
        <property type="nucleotide sequence ID" value="XM_023582307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDQ1"/>
    <dbReference type="GeneID" id="35406129"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12673"/>
    <dbReference type="HOGENOM" id="CLU_1627130_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="202" mass="22964" checksum="4C77A6D74E76BD1D" modified="2013-09-18" version="1">MAWATTEENTCLRARQIRRYYDKHIGSEGPLKYGDKILLSDIDLATTFAPDYSLKLCAKGEEEYPEQWDSKPKSLSYTLSNFRLKAKELAAAMGKEIEDFMTKDATNIPPVFLGGNGDRAHVRSLELIAGCPKRELAEVKKGKNAAEEEAKQYLARAKKAEAQLKRRLGEREEEEEGEDDEDRKRKRRKIGEASDGVRETIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEJ3</accession>
    <name>S0EEJ3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_14087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435138.1">
        <property type="nucleotide sequence ID" value="XM_023581279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEJ3"/>
    <dbReference type="STRING" id="1279085.S0EEJ3"/>
    <dbReference type="GeneID" id="35407541"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14087"/>
    <dbReference type="HOGENOM" id="CLU_008719_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT73060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="542" mass="61277" checksum="5695674F29060EC0" modified="2013-09-18" version="1">METEKPLQRNNSRVAIGCTACRVRHVRCDKELPSCSACLKAGIDCERALQIRFRPGLGPSTGYAFSSDQTWVRPAKFLEYVDETDRVSQDYESQEQEDMCLAQDLSIDPDLAKPGQPSSEAAHVSPPSQIVHTISPMPDISHHDFANSPASSQLTRHLRYSSELVRSPDSPYSRPPMQFTAREAELIKNFTENMALWADATDVHRHFELEVPRRSLYFPVLRYAVFSFSSRHLNRDKADTSTEALEYYNSCLSVLIEAVDKASGHIDEETLAAIAILRQYEEMDAEDMEMHLTGTSRIVNSMSEFDFNGGLGEAAAWLCLRQDIYVSLTRLRPLRSNLENYLQSDIFRRTDDAAYANKMVYLLARSLGSIYPSDSAISNESLVNIRLEVDGWFDSKPAAFNPILESARNKDGGNSLPIIWVLSPFHSVGLQYYHIAKIVLAMSFPIATDSVFEQIRESKKVERTIRSHLLQVIALASSHAKAENALFTARHSLSIWGSVFTDRMDQDMVLDFLRHIQQKTGWQTESLSSSLQQQWTQDSNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEK2</accession>
    <name>S0EEK2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435153.1">
        <property type="nucleotide sequence ID" value="XM_023581738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEK2"/>
    <dbReference type="GeneID" id="35405621"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12165"/>
    <dbReference type="HOGENOM" id="CLU_2654678_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="76" mass="8849" checksum="11EBA71C489AE58E" modified="2013-09-18" version="1">MNLQYVSRQPVKGPSLWLSVTPEDEARMRRHPGQDMIYSIPEVIPHRSVGSGRIMSISNMSYRNFPARLLQNEHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEP1</accession>
    <name>S0EEP1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to neutral amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434415.1">
        <property type="nucleotide sequence ID" value="XM_023581769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEP1"/>
    <dbReference type="STRING" id="1279085.S0EEP1"/>
    <dbReference type="GeneID" id="35405649"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12193"/>
    <dbReference type="HOGENOM" id="CLU_027816_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="54"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT72337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="477" mass="51184" checksum="3249D8ADC9CA74E9" modified="2013-09-18" version="1">MGIVHANNREPGTFDPAPILSQEGLNQDNARPTVAHDEVFGDITEDGPNYRDVGWLGTSALMMKTQIGLGILSIPSAFHTLGLVPGLICLLVIGGITTWSDYIIGTFKLNHREVYGIDDAGGILFGRFGQEFLGISFSLFTIFASASGILGISISFNALSTHGTCTATFVAVAAIIVFLCASIRTLGRISWLAWVGVISLLAGVYVVTIAVSIQDRPSAAPKINLQHEWKSDYQLYEKPSFTEAMSALSTMVFAYAGTPLFFPITAEMRDPRHYTKAMLLCQSVATATYIIVGVIIYYYCGSYVASPALGSAGKTIKQVAYGLALPGLIVGATINAHVTGKYVFVRVLRGSRHLTANTLTHWATWLSLTFSAALLAYIIASAIPVFGSLVSLVGALLGTLQTFQPYGCFWLYDNWSAGKQEKSLKWVLMVVWSSFVILSGTFLMVAGTYGSVIGVIDSYKVSEGSAAFSCADNSNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEU4</accession>
    <name>S0EEU4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434465.1">
        <property type="nucleotide sequence ID" value="XM_023581835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEU4"/>
    <dbReference type="STRING" id="1279085.S0EEU4"/>
    <dbReference type="GeneID" id="35405708"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12252"/>
    <dbReference type="HOGENOM" id="CLU_018980_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="591" mass="65921" checksum="15F75C27C83FE610" modified="2013-09-18" version="1">MAPSQAPFLYSAVHSDSRFPEPKFDPKAVTRASWEPPKPRKKPNGPLVSFNTHPDMHQVLTYRTNEYASMSPRSKRFIKWLRHVQSGLRVLQLVSALGLLTLMILIDKVPSLEGWVMRITPGVVILHCIYGIYHLSRNAAGRSPASSASYQLFCGVTDLGVAPLYAFGALSVRTKSEDWITRLSDQSLMNTFKPVLFYTFVAAGGLHLISLAIAGWLGFMFRKISLMPPDMNPLESHLTARPMHKRNKSSVMTASTMDSDARLSTPRSARRESLVPQEGIHDGIDAPRAIPFTHTRNGSSTTIGTRDSRTKLPPPPQYQRGPGSPRRERRDSAASRATTRTTATRSIYHDAYSEIPLDDQAGSRPSSSYNRHSQPRPARFTETWMPTDSLISRTNQRNRELEAAKTSAANRENKSYEALAQRYAHDDSDSEYGDENNPSYDLGVNGDELRPHPLRLNPPAAQQERKSPPRAKTPFFPFKNSLTDISTNARRASASRDIADEKPGLAPGNRQSSIQPESEFYARSYGELQSATPPIMIGSDNRKVSTGNDYNQNTSTTYGRRNVSGKMVEEGRAAGNRYSFLDGRKPLTERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFZ3</accession>
    <name>S0EFZ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to nuclear protein bimA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433392.1">
        <property type="nucleotide sequence ID" value="XM_023580649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFZ3"/>
    <dbReference type="STRING" id="1279085.S0EFZ3"/>
    <dbReference type="GeneID" id="35402103"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08627"/>
    <dbReference type="HOGENOM" id="CLU_008850_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="598"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="632"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="666"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="700"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="768"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="823" mass="91379" checksum="E771880284F93A29" modified="2013-09-18" version="1">MAPTPTVTSGLLRQTIYYHLDNAFYHNGLFFAERLLAQDPRSSESTYLYALCHLRLGDFRSAYDVGKPIGYRGVHLGCAWVFAQACLALERFKDGISALEKARSLWASKCSLGKHSATTRTALPDAPAVLCLLGRLHRAYDDKKKAVSCFEDALQLNPFMWDAFEALCDLGVTVRVPNVFKTSDTLVHGFDVETSPLISREGSVPIVTDIPMKNSQRNATMDVAGDPFSSSHSPTIHELANGDSGQEVDKSEFMQKIQEGRMRYATSTNSSSGFDGMETPPGTISSVTTSSRIGHSNEPPQAPPRRTRHAQAIDQAQEAPPRMNYRIGSRRTRAQDKGLPEQSTENVMTDASNAAPSASLRSSIPAAERKRTISGHPAQRTANSEEPATTRRSARLNMFRPSSKANSGAAGMGTAAVRELKKARPPISRIVRPGSSGSSVGRVVSGNRKPLEEAQADMDHSELPKAKEIPPPPPVHKTSELDAQKIEEGLRWLLDLVMKLANGYYSLSQFQCTESLQHLQSLPMSHQNTPWVLAQMGRAHFEQASYAESEKFFRKMRVQAPSRLEDMEVYSTVLWHLRRETDLSFLAHELVDSSWLSPQAWCALGNAWSLARDHEQALKCFKRATQLDPKFAYAFTLQGHEHVTNEEYDKALTAYRQAISADRRHYNAYYGIGRVQERLGAYDKAYTHFHAAQSINPNNAVLITCIGTVLEKQKQIMPALQAYSKAVDLAPRAAQTRYKKARALLAVGQLDAAQKELIILKDLAPDEATVHFLLGKLYRSMGEKQLSVRHFTIALALDPKASQQIKEAIESFEDDVEMDDSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGQ6</accession>
    <name>S0EGQ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_10253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436289.1">
        <property type="nucleotide sequence ID" value="XM_023569015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGQ6"/>
    <dbReference type="STRING" id="1279085.S0EGQ6"/>
    <dbReference type="GeneID" id="35403718"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10253"/>
    <dbReference type="HOGENOM" id="CLU_009377_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="328"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT74211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="693" mass="77970" checksum="DAD7876D6B2207E8" modified="2013-09-18" version="1">MIRFDAIGYFPVRTAEQSKKRAAWLERHRECDSPNKESSSPRSSRSHYRLFICMKGVAQLKNSEQKIDRIENRLEGIEQLLRRAFDEPPNTRNVPRPPESLATDSFNVSQDFANSNRNGPSYTNSEIALEGSSSLKAATVYASDFFQTVLGHSPAADTSTRVNAALSSLKQMIEINSYRSMGDRIPSRRETQNDGIRDLAMPPLQSVLAILRELKETKLATLMIISLFISKDRLIDCCREIYFAVDNFSLPTFLIANATLRYLFQEKAQASQDPLFRDEYRKLSQLCRDNLETAMNKFRVLAPPSLENVEAFLLGAIYAIEVSQPMLAWQLVSSAAGTCQTLGWHQLVPNSDSTTDRKISLFWLTYLLDKGLSLRLGRPAVIHDDEITLPERLDKADVPGGWRGLLTQWIRHSRLVGRAYQDLYSPSALRASTHERGERARRLVAALKQIMDGSLMPLGQAHLMEHNTVDFGSAPNRMIKTVLKADEVWYWTTLTFIRRAVPSTESGHGAVSPVCLESARMAFEAHGECMRMTDPSSETKALYLLWTIIYTPFVPLIVVFCNVIETSNPEDIRILGEFCESLKPLCGIFEAIQELHDLCQVLYNLAISYVEAKSQSQGSLDKMVQDGFDVQSKSTQGAASFSTGYCDTFSTGSSIPMPQLNSHVSQVRDWISGNMQWMDVSQEDFSEFLAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGT8</accession>
    <name>S0EGT8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to transcriptional repressor rco-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433662.1">
        <property type="nucleotide sequence ID" value="XM_023580982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGT8"/>
    <dbReference type="STRING" id="1279085.S0EGT8"/>
    <dbReference type="GeneID" id="35401805"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08329"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="272"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="393" mass="43378" checksum="1447EB06BCCD6DDF" modified="2013-09-18" version="1">MQSADRDHFFETDAVQASRQRKAAKASNKNGDPVVMKSKILAAVPDPAAPLTSVFIAESAGAVRRINLETSETKTTYRGPKAPVTCLATGGQEYKTVFAGSWDKDIWSWDIETAKPGRKFSGHDDFVKTIICATVSGKHILISGGADKKIFVWDVESGKRLHTLQDPTTTMLAVQHLAIDPVLSDPTTVVFASAGSDPHIRRWKVTLDSYKQLPESFSDRPDAERLTIQEHETSIYRLVFDQMSEDADLWTASADGTAKCLARSRSFVADDTLTHGDYVRGVLVTDQWVITAGRDENVKVWDRSSGKLYCTLVGHYEEVTDLVLLQDTDGTPRKVCSVSIDGTVRTWPLGKSELDEVVVKIQKAAEPKKEEEEKCGNLLTAEEEAELAELMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH16</accession>
    <name>S0EH16_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_09844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436122.1">
        <property type="nucleotide sequence ID" value="XM_023568209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH16"/>
    <dbReference type="STRING" id="1279085.S0EH16"/>
    <dbReference type="GeneID" id="35403311"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09844"/>
    <dbReference type="HOGENOM" id="CLU_055491_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT74044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="161" mass="17618" checksum="4F00B7AF3D5FF145" modified="2013-09-18" version="1">MFAAYLEKLANAGGPEVTYEAGCHCGYIGLSVALSPPLPKHEVINCNCSICRRGGYLLVYPACEKVTWHNDSDKRVSRYQFNTKARDHMFCPKCGASIGIDFARVWPEAPRYGISVRQFNNIDLDSLQYMKLDGLHTAEPGVDLSGQEIGAKADDAPASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHH0</accession>
    <name>S0EHH0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436539.1">
        <property type="nucleotide sequence ID" value="XM_023569305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHH0"/>
    <dbReference type="GeneID" id="35403978"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10514"/>
    <dbReference type="HOGENOM" id="CLU_976717_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495961" evidence="1">
        <location>
            <begin position="18"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="239" mass="24649" checksum="3415F68A67E69EF1" modified="2013-09-18" version="1">MKFSLFSLVALATSAMAAPAAQVAARQVPAVPASPNGAVTQVESIATSQTVTKTVTKKITAVSVSNTGGVVKVLTIAVEQVKSQTTTIKEVITKVKSNAISKAAAVKVVTAEVHSLNELLTAVVNQLKDVVSIKINIPDVKVILGLVIQLLHELVGVAKEVLSILGLDNVIGSAFELLFQTVATLLGLVTQLIGDIVPGLVDILSNILDTLSGTPLGPIIQPVSNIFDGLTGYLTQGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHP3</accession>
    <name>S0EHP3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pectinesterase</fullName>
            <ecNumber evidence="4">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_09906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436233.1">
        <property type="nucleotide sequence ID" value="XM_023568139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EHP3"/>
    <dbReference type="GeneID" id="35403373"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09906"/>
    <dbReference type="HOGENOM" id="CLU_001425_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF58">
        <property type="entry name" value="METHYLESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485267" description="pectinesterase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="2562"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="348"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="762"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="1097"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="1444"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="1802"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="666"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1415"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2153"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="718"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2156"/>
            <end position="2175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT74155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2562" mass="266102" checksum="54CF9375B972F897" modified="2013-09-18" version="1">MARLSAWLLLPLLCGSSLAKEGQVVPAFVDSSSSHSTRFASLHDTPLTGNVPVADGGSSSFTPQVNPLVKRSSASASETVPSGTTSSASKSETTSIVGSVSLSEASSTIEVTLTSGTPSGLSSETSLSSADGDTHSSSTAVASHDASTSVLSDADTASTDAIGAKTATAASDTTTGSASTSSLESSAGSGSTTGTATSNVDTTSASSVDSSATSNTATGPTTAGETSASGNVASSSESSAGSVTTYGSATSDASTALTTSLESSATSEASSGSLTASGTSASGDVTSSSESSAILNSPETSETLTSSGTQTSEASHSLTTEFPSSFTSSQQTSESVVSTSTDSPLVLTVAADGSGDYTAINDAIKAAQTSGYPTVTVLAGTYTENVVIQATPTVTIVGEVSNKRDVSSTPKVVIDNGGNANPALSFSTASAAGITWKNIKFSNTQAGGSGGAVFLRGSKNAFYNCQFYAAGIAAITGSYASAIVANSYIEAPDKVLYNYPSLYLYGTTVTATNSNGLIVYNKGALAGSTLYNSTVVFDTCDISQKSGSTNTRVFLAAGNGDGSVAVFRDTSIGSFITATGVYVDTKTQSKLNSYIEFGTTGDGSYSNHVADRSKYVTLVTDPKDLSPYEISAFFKGAYPSVAVSSLDWIDQGVLSAIQASNAKDFKQDVETTTSAAPTTSESSSTTSESATTTPDLKKTTSEAVTKAADPVTTTSDVLSKAASATSTTEESTSAAPTTSSCSLPSAVPSTALVVGPKSNPCASYDTVASAVAALPADDTTQYIYILAGTYQGQVSVVRTGATVFRGETTDGSSPKNNKVTITARNAVLSSSGGSLGTATFAANKYEAKLVSFYNINFENSFDPTTNNIALAVYAKGTKVAFYGCDIDSSQGTLYLDYGNFFFSHSKISGTTDFVWGQGAGYIYNSVIVSRGSTAGQAIAAHKYQGQYGGSRFVFDLCAVVPESSSVPEGSTFLGRDYSTNSNVAFVNSFLDGHIAGAGWKIASPSTFTGTFTEGNNTGPGWDSSARISAATIASDTSSFSAAGILGSDSWIDKAAIAPFQGWPDSVYGKDAASTTTTSAATTVSSTSSATAVGATLTVAPSPTGNEYKTVASALAAIPDDGDDYTIFVKAGSYNEQLTLTRSSGHVTIRGETSFENDFTQNEVLIWFKLGYSTGASRNEETPVLFWKTTSASSGLSLYNLNFTNTYPQTSDTAALAADFFGNMAAYGCAFDGFQDTLLVNQGIQVFSNSYISGSVDFIWGYSKAFFHGCYVASNTANAYITANNRKSSSWAGGFVFDKCKVTYTDSYGSNFGTTSLGRPWSQYALVVYMNSFLDKHISPQGWATWSSSNPQTSNVLFGEFNNTGPGNWTTSRASFATKLTESQAAAYSLGSFIGSTSWLDMKAYNLVPSYAVDGSDATTDPETDDTWPVHPSDGTTPPKGAVTVSVGGEKSGSYSTLTDALKSLPKDSTPQTIFIYAGTYEEQVPAINRPGPVTIIGYTESDPGKTYASNQVIITQAKGLSVAGTIPAGRSNADTATIATASTKIAFYNVKFVNSDNLDGATPSYVTLAASIYGNDIGFYGCSFIGWQDTLLNGATNGYQYYESSYIEGAIDFVWGYSKAYFKGCTLAAKRAKSAITAQSRSSASAVGGYIFDQCLFTEAASATVDLQGQVYLGRPYSAYALVVIKNSYLDSTIQPAGWKIWSTTDPRTDHITFAEYNNEGPGSWEKNTAAREAFGFATLLTSDTYSIESVMDSTDWIDMTYWDSITTPQPSTVTPTPVPTAPYGGKTPPAGAYIVSKDPIDGVPTYDTIQAAIDALPLSTKVTPTVFIYPGTYKEQIVLSRPGTTFFIGYSESPEDNSKNQVTITYDKGIDTQAEASNSDSATFYATGNYFQAVNINFANTFGTTANYASLGFAVKSSKFASLYGCQVYGNQDALLINGNLFAYNSLFTGNIDMIWGSGAGYFLKSTIAPNRDGIALTANKKGTNTGPSWGFVFDQCTVSPAGGASYSNIYLGRPWDQYARVAYIESELGACIAAAGWQAWTKADPRTANVIFGEFDNSGPGSSTSQRASFAKQLSGEEVAQFELGTFFTSTAWINMTLVDATPFDAGIAATQTYSSTTVYTTQTVTTSQTALVTTTGADVTVTEKSTSTLDVGTTITPDPTTKTNTEKSTTTQTQQITQGDSVVTVKSTDVVDVGKTVTPADVTKTSTNVVAATVTSWITTSAKAVTTTVSTTAVTVTPKSVTQEETDFTTVFATRTSSPKAVTVKSTTTTTIGTGGTTTTSLKATTVVSTVVTTSVKTVSKTTTLKCIPTQDKRDLGATAVLKPRAAVVFGNPSFDLSSGLTRRDLDLGSINLEARAEALRTVTVTVVSTYTTNVKTSTATVPGSTTTTELITTKTVGKTSTLKPVTVVEVSTSVATRFATVTIAGSTSTTTQVTTKETGKTTTLKADTTTVVVDATSVVTEKKTTTLPASTVTVYKTLTQTLAAGTVKVTSTNTVKKTSTVTLDQQTVTSWATVKTTLQPSSTVTQRSTVSKVITSVVKSTKTNWATKTSKGAAACTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI09</accession>
    <name>S0EI09_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_09723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435555.1">
        <property type="nucleotide sequence ID" value="XM_023568343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI09"/>
    <dbReference type="GeneID" id="35403191"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09723"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT73477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="560" mass="60233" checksum="4AA431166852F02C" modified="2013-09-18" version="1">MNARVNDMDTRTQDGGKPETTSGSQTDHSIPASDSDDTEVPLIPPARFWGLCVGVLLGLFLSMIDTSIVATSLHSIGVDFEVLEDVNWVALAYTLAYLGCAIVFARISDIVGRRDAFIAAYIIFFIFSLACGFAQSINQLVAFRALQGIGGSGLYSLTMIMLPEISPDRMKQHIAALVGLVITMSGVLGPVLGGILTHYASWSGPVGFVSLVIFVLTWPKPEYLPSQERRAWKELDFLGSILVIAAAVLVVFSFQNAGTGRSNDGWKASIFIAPLICGLLACGLLIAWQIFIQHRWHDRFAPAFPINIFRNRIYSTAVANTLLNGFPYLLLIYAIPLRFQVVSGKSALISGVMLLPMLGTAAIGSLLAGKINATKNYTFESLALGSSVMTIGCGLLTSLSHEPNDAKLLGYMTFCGLGFGLTVASSTMLSTVEVPIRDYAPAQGILSQVRLLGGSLGIAASSALLNEKSSKYLSGVLTAYEQATIGGSNTHLTSAQWSAVRYTYADAFQVEMKIATVVAACSVISAFGAFRKGRLLIAEQRKIIVREEEDRRRAQTAQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIP3</accession>
    <name>S0EIP3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434331.1">
        <property type="nucleotide sequence ID" value="XM_023581667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIP3"/>
    <dbReference type="STRING" id="1279085.S0EIP3"/>
    <dbReference type="GeneID" id="35407192"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13738"/>
    <dbReference type="HOGENOM" id="CLU_148217_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="110" mass="11932" checksum="C411A7FB4EB8EB2E" modified="2013-09-18" version="1">MPSVGNPNGPSKNRLAARASSARKERRKRSQAPKDKVAKADTTRGARPGLLPTSGPRAKVSAKKARKIEKRLAHAMKRKMEAEGEAEMKDAPEVEGEGEKAEEVEMGDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIV5</accession>
    <name>S0EIV5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to aspartic-type signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435890.1">
        <property type="nucleotide sequence ID" value="XM_023568739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIV5"/>
    <dbReference type="STRING" id="1279085.S0EIV5"/>
    <dbReference type="GeneID" id="35402835"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09366"/>
    <dbReference type="HOGENOM" id="CLU_013253_9_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496022" evidence="5">
        <location>
            <begin position="18"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="60"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="642"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="400"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="743" mass="78024" checksum="217F3DDB754FE00E" modified="2013-09-18" version="1">MLSALFLAIAAPALAHAAAPQEDGLIRFPLKVSTGAPVVKGVTKRQNEVALESQQNGFFYSIDVELGTPGQKVTVNLDTGSAELWVNPVCSKAQQPAFCESFGHFGESSTWVNLNTTGGVVYGTGYAYWNYGYDHVVIGSANIRNQVFGVAYDSSFTSVGIMGAAPDLNGWDAPYPLVIDSMVRQGLIKSRALSLDIRTLDSDRGAVIFGGLDTKKYTGHLEKRPIIPAESSPDGLTRYWVHLDGISIIQDDGSEDAIFSQTNGQPVLLDSGYTVSALPGAIFNKIVAAFPTAQRTPGAYVDVDCSVADLKGTVDFKFGNTVIKVPYADFIWHNDDRCVLGVFQDDEFPVLGDTFLRAAYVVYDWDNRNVWLANNEDCGTNLVAIGTGPNAVPDLVGECGSDSTTTSGSPTSTETASESVTESVSSAETTADTTLSFSTTRYSNTTFTTSKPGSTSTGGSGNTYVLPTTSAPSTTITSTVTTSKVYTVTACPPSVTDCPVGHVTTEIITSLTTYCPGSEATGVAPQPTKGPVKSTLTSTRVYTITSCPGSGSCNKGDVTTEIVHNTQIINPEQPTGVFTIPEAIHCGFGNFGCKEATTKGYRTVTITSVVKAPKPTPVPGYCTTCGPPGSNHHNNGTFTGHYTKPGYEQPTKGHATQDYPEPTGTASKPTGGNPLEELNTYKPTHVYAQPPNTVATVVKPTGTPVGSTPSEPTGTSPAIVNGASAWNVPALAAFIVGAFVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIV6</accession>
    <name>S0EIV6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437019.1">
        <property type="nucleotide sequence ID" value="XM_023569865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIV6"/>
    <dbReference type="STRING" id="1279085.S0EIV6"/>
    <dbReference type="GeneID" id="35404479"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11015"/>
    <dbReference type="HOGENOM" id="CLU_027946_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="510" mass="55035" checksum="DD95D6AB3FD3CE82" modified="2013-09-18" version="1">MPLPRQCFSRWTIISVVAIFIIVTVTVTCATYFTLAKKKHHAFDWTTVMSSRGDVIPDFSFAGYHNSAIILPNIAAPNITVSFNNSVDVRPAIQAAIDSIASSGGGSVILPAGKWSMTAGLSLSSNVVVTGSAGGKTVLSLSEKPSVPVFTLGSSNTVKPKYGFRSNITNDYVPIGSSSVEVVNSSGFAVDQLVYVSRIATESWIEANGMSNLVRDGASQTWIPENKRFMTPNQISGVYGNNITLKIPLTDNIELDYLQPELIVYTPPESNSEMGIRDLSIEVPGTCSGAPLTDKTCNSAAVRFPSWTVDSWASGLTLKGFNKFFQIDQDASRITIQNTSMNRDKDISGSALPFDIMIQGSQVLVQDCEQVGISSARCFSVATGSLTPGPNAVLRHKTQSDSQTIYPHQRWAQGLLVEDTSVATYFVNRNIKGTGQGWSINGGVGWNIDGYCEFESPPTGINWCIGCGEIGNEPKGNGTLLETGKRVEPQSLFQAQLQNRGVYRYDGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ21</accession>
    <name>S0EJ21_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to Putative sterigmatocystin biosynthesis lipase/esterase STCI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436862.1">
        <property type="nucleotide sequence ID" value="XM_023569683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ21"/>
    <dbReference type="STRING" id="1279085.S0EJ21"/>
    <dbReference type="GeneID" id="35404317"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10853"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="92"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="338" mass="37426" checksum="1CE5340BE83C7557" modified="2013-09-18" version="1">MAISREERLKLATIDPELDDYLKTITIPQIDTSDPAKAIASLRWYMKSLHKLPDPESGVVERDIYYTARDGLTLRAHVYEPAERSKPAPPLIVYIHSGGWTIGSPEDAERSCRDIVQRLGVVCLAPSYRQGPEDPFPASINDVWDGLKWIAANADSELEVSLSKGFVIGGSSAGGNMAAIASHLARDENLTPAITGVFLLAPMILPPEKKDALPDKYKDFYLSRTQAECKDDPILTPALDKVFHNSAAGDMSSPLFVPFIWPTGHHGLPKTYFQVCGMDVLRDEALIYEQVLREDNGIETRLDIYPGMPHIFWGAFAHLSQGKKATVDLVEGIKWLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJR4</accession>
    <name>S0EJR4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to 15-hydroxyprostaglandin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_10962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436968.1">
        <property type="nucleotide sequence ID" value="XM_023569805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJR4"/>
    <dbReference type="STRING" id="1279085.S0EJR4"/>
    <dbReference type="GeneID" id="35404426"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10962"/>
    <dbReference type="HOGENOM" id="CLU_010194_13_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT74890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="297" mass="32186" checksum="0AE74B5F6CB830EB" modified="2013-09-18" version="1">MTDTTPRQIALVTGGGSGISLAFVKKIHEAGYHVLIADLTLHPTASTWIGSLQPSDADRVKFFKLDVTDWAQLEAAFDYCVKIFNGTPTVVVPGAGVYEPSSNSFWEDRDSDSRYKVLDINLVHPIKTTRIAVRRLVEADLPGTIIHLSSIAAQRASIITPLYTASKHALSSFVRGMAPLAQTSGIRVLGVAPGTVSTPLFSEKPEAAKFLDMERDYLLPPDAVANAMMALLTQTEEFEPGTMLEVCHETEWRKVSLLDDPGPQGPASLTSRKKDAVKDIYKYLAPGKASADGITTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJX3</accession>
    <name>S0EJX3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to cutinase transcription factor 1 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436245.1">
        <property type="nucleotide sequence ID" value="XM_023568965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJX3"/>
    <dbReference type="STRING" id="1279085.S0EJX3"/>
    <dbReference type="GeneID" id="35403674"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10209"/>
    <dbReference type="HOGENOM" id="CLU_006329_9_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="809" mass="91622" checksum="5E2F53317DE3EB5F" modified="2013-09-18" version="1">MEEAMSHGANPRRKRASKACVACRSRKVRCDVTHRPHQCTNCALDNIQCVVKDRRTKYRKRSPVVLEKQQRTQFRHSLQAILPKDPSSAVSDDMDTLNDPCLEPGHSVECGPESPSMCFEAVWDEPEISFPAERFIQGPTESRDKESEIFDMVLNQRKDSDFTVVSDSSRLHQTESKPAPNFDATMSGQSHIIYSYYSFLDLDISGLLPDDINYLEGQGCFRVPTPEALDEFVQEYFLHVHPALPLLDEAWFWTIYSRPARGRSNLSLFVFQAMLFTACSFLPFSTLKSLGFASVHNARNTYYRRSKLLFDLCSERNLVSSTQGALLLSYNGTMKDQKRTNSIWLSTAIHLAQAAGADQFHTSLNPSLTSVNELKRLWWCCIVRDRILPLGMRRQLHITSLDVAHTNYLPTEKDFWREIDGSQVYAPQTKRTLVRLFITLCELTVPLTDVIKIVYPTGRLTDIHSPVVHDAQKGRESLQSCEAGLEAWFERATIQFPTPAGIITREGSLVLYTNLLYIYYYAACFALYQHKAFIISQEQTKATSDLQQTKSKIEDAALGITENLKELIQLRLERFLPISIAAYIAVPLVLHILDVRLAKRPLQIAQKQGKLNVYVETMKTMQKLYDGVDDVWTFIRTAMDYATIQDAENETSSPNGSCIDAVGCLGSKSQLTKGNDYANDWGNVLVMEPILYFRLSRTIDHSLALGRYSEDSTLGHAAPHTRLPSPRLLTIDIGSPEQTVDDTACEHYKAPRADAKSPEVSQDQFSLGPQMLDDMHEFVHYDFGMDDMQAPIDFNRSERQAGETDVLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKM0</accession>
    <name>S0EKM0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437218.1">
        <property type="nucleotide sequence ID" value="XM_023569743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKM0"/>
    <dbReference type="STRING" id="1279085.S0EKM0"/>
    <dbReference type="GeneID" id="35404370"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10906"/>
    <dbReference type="HOGENOM" id="CLU_2085029_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="117" mass="12316" checksum="B4221588855E67C5" modified="2013-09-18" version="1">MDTHDTACIDDRVVDASPDAPLQPAKPLEPPSPGETSTEIEVPVTTQDGVTVIPTEAIPSMQVATATDLVTESLILQPVETVIESVTKLGQALVETTVTTVAYTIIDQNNPSTMTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKM8</accession>
    <name>S0EKM8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_11077</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437228.1">
        <property type="nucleotide sequence ID" value="XM_023569934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKM8"/>
    <dbReference type="STRING" id="1279085.S0EKM8"/>
    <dbReference type="GeneID" id="35404541"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11077"/>
    <dbReference type="HOGENOM" id="CLU_042529_21_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT75150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="204" mass="22755" checksum="01D1F3FD58D18F2C" modified="2013-09-18" version="1">MSSAFVQRPAPDFSATTLFPGGEFRDIKLSDFKGQWVVLLFYPMDFTFVCPTEIIQYNNALDRFREINTTVLGVSTDSHFTHLAWVEKPRKQGGLGPDLELPLIADKSTKISRSYGVLIEDEGIALRGLFIIDPKGVLRQITVNDLPVGRDVEETIRLVKAFQFTDEYGEVCPAGWQEGGKTMKADPKGSLEYFNEQGENGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL55</accession>
    <name>S0EL55_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to hexose transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11573</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437592.1">
        <property type="nucleotide sequence ID" value="XM_023570486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL55"/>
    <dbReference type="GeneID" id="35405034"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11573"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="23"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="520" mass="57801" checksum="6879B927A2233521" modified="2013-09-18" version="1">MTFERKHVSRLVPTDHKILMPLLLAVTIVNSATLGYDSSVMNGLLILPSYSEYFHLTTATEGLNNAANWMGSIFGAFLMGPIPDHFGRRRAIYIASIVTTIGIILQAAAQNIPMFVVARFLVGVGSAISNGAAPTLLGELLPPRRRARVLGLFFSCFYVGSLASAIINYGSQNIQSTWAWRLPSLLQFVPSLWAVMIVPFVPESPRWLISKDRNEEALEVLVIMQGKDKTDLQKGSEQLEEIRSTILREAQEYPRNPWREMISSGPNRRRLAILCSFGPMINLFGNFIISFYLTKILNQAGITNTTTQTQIQVIINCWSFAVAVLGSFMLDFLGRRLQTFIGVGGMVVTLLLIGGLIKRRFQYLFSLMLVNEISKGFGESTNNSAIYGTIAVIFLFQGFYAFSITPMTSLYPTEVSPFKLRATGIAIFRMLDSSAGLLASFAMAYAMADLGWKFYFINASWDFIFLIVAYFTFAETKGLELEEINAKFGDSTVVEAVVEDSASNGMDSKDEGWMVKMQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELH2</accession>
    <name>S0ELH2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435311.1">
        <property type="nucleotide sequence ID" value="XM_023567940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELH2"/>
    <dbReference type="STRING" id="1279085.S0ELH2"/>
    <dbReference type="GeneID" id="35403552"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10085"/>
    <dbReference type="HOGENOM" id="CLU_1266974_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="218" mass="23728" checksum="6FAE3DEE85F8109E" modified="2013-09-18" version="1">MSFAPELTPTEQLNKTAEKHEATTGGVTRELANHTISSIAALKPLTSDSKILDNACGTGIVTVIILKSGINPEIHTFDVAENMVSIARERFSAHPTSKRPSWQARNSPFLTTPSHTAPRTLVLCTSPTRIIQEIQAQIHSDETPFKPPVSDIWLDPDHTKALLSSPGFEVTSTPIDRHLGGEMADGVVDLLFHGLGSKVSNSWSKEEKEKGSEIMKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELI7</accession>
    <name>S0ELI7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable endopeptidase K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_11704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437717.1">
        <property type="nucleotide sequence ID" value="XM_023570633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELI7"/>
    <dbReference type="STRING" id="1279085.S0ELI7"/>
    <dbReference type="GeneID" id="35405165"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11704"/>
    <dbReference type="HOGENOM" id="CLU_011263_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012429586" evidence="8">
        <location>
            <begin position="16"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="149"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT75671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="401" mass="41195" checksum="67EB40A2B1045087" modified="2013-09-18" version="1">MRSATLLALLPFALAAPSAPSRRAEPAPILRPRGVKLVDGKYIVKMKKGFQASSIESWVDKMIEYIEADADYTYSKGFGGFAASLKDDELNKLKHDPNVEYIEQDAYVTITATTQQSNAPWGIARVSTQSPGGSTYSYDDSAGEGTCAYVIDTGIDVDHPDFDGRAKFLKNFAGGSDSDGQGHGTHVAGTIGSTTYGVAKKTSLFAVKVLGDDGSGTNSAVIAGMDFVSGHAKEENCPNGVVVNMSLGGETSDAVNQAAKAIVDAGLFLAVAAGNDGKDASGSSPASEESACTVGATTSDDILADYSNFGSVVDVLAPGTDILSTWPNGKTNTISGTSMASPHVAGLAAYFLGLGQKAEGLCDYIASKALDGVISGVPSGTVNKLINNGIGGGSNSSSFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELM7</accession>
    <name>S0ELM7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436885.1">
        <property type="nucleotide sequence ID" value="XM_023569711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELM7"/>
    <dbReference type="GeneID" id="35404341"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10877"/>
    <dbReference type="HOGENOM" id="CLU_092860_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="259" mass="29122" checksum="F9D32ED70A72EE43" modified="2013-09-18" version="1">MVYLPPDQHGDCLKCYLVTPFADDELKAFKSAFERGAYYKSAPMMQIKIMHAPDDYLGKSHQYMRAKETEAGNTNPFIVVDEEAKSRRAVWYIDQFAEEDQVEDGTAESTDVVMKILIQTQCLGINYINYAIANSSIEEDLDNCSVELPLTNDFYQPDPQDCGGPDFEYKQPQQDVWVIAEPGEFEESTDPELLNDFSPHPDKVVRLKEDAAESVGLVSSWTISGDAKPIDLAGKEFPEGSVVLQQKYKPGFPWPADSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELS3</accession>
    <name>S0ELS3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="10" type="ORF">FFUJ_12045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELS3"/>
    <dbReference type="STRING" id="1279085.S0ELS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12045"/>
    <dbReference type="HOGENOM" id="CLU_071892_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="245" mass="27914" checksum="08106414BDE208BD" modified="2013-09-18" version="1">MAIHNNFPRALYKTRPLLSPPNAWRSPFSNVSRRLTTSERTRHSVECSPRKPKWGSLTPEQQDYISAAIRVNQAGELGAVLIYAAQTPIVVKQHPELRPLMQHMYDQEVGHLSTFNDLITKHRIRPTTMYPLWQVLATGLGWATAIMGKEAAMACTEAVETEIGTHYNEQVEEVIKIIQGWEQEGYEAGTEILEFLQTLRRIRDEELQYLDHAVEHDAKNAPLHDLLTAFVRTSCRGAIFVSQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELV4</accession>
    <name>S0ELV4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437857.1">
        <property type="nucleotide sequence ID" value="XM_023570797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELV4"/>
    <dbReference type="STRING" id="1279085.S0ELV4"/>
    <dbReference type="GeneID" id="35405312"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11851"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF274">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="254" mass="26773" checksum="4EC4CB404276CD60" modified="2013-09-18" version="1">MVRVFITGSTDGIGQAAAKLLAEQGHQVVLHARNADRAASAKAAIPNAAAVLVGNLSSIEETKKLAKDANKAGPFDVIVHNAGIGYGSTALREITSDKISAVFAVNTLAPYILTCLMDKPRSRLLFMSSDSHYSGDETLKNATQSHSYGNTKLHDTMLAKAFARRWTDIQVLSMHPGWVKTKMGGSSAPVQLSEPAKALASWVAGKGSLTKATSGAFVTTSGESRPHPGADNVNKQEELLEMCKSVSGVDVPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENA6</accession>
    <name>S0ENA6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438228.1">
        <property type="nucleotide sequence ID" value="XM_023571172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENA6"/>
    <dbReference type="STRING" id="1279085.S0ENA6"/>
    <dbReference type="GeneID" id="35407637"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14185"/>
    <dbReference type="HOGENOM" id="CLU_778557_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="356" mass="39111" checksum="3DBD816895705964" modified="2013-09-18" version="1">MEPDDHEPPSSSSFASSDVCCLPSPSSLKSTATSSRKVSPPPELKCETKQPPAPESPAPPSFGTDHLRLPEALADFKRKADAGGAATFRRFDYDPRNGRIATRRPGLVHEYFIEEFVYHLRLQLRSLGLQHQKTITGDFINKIRSKGSADIGLITTDSSDVPHAKRLTRSPDASFVHKDAGLSGVVVEVAYSQDGKKLPGLARDYLLHSYGKIKAVIGFDINRENKPCSVSVYRVLKTPSDNGRIKLGVEAVVHESVSSLTLLPDMISLLQAFRNSDNTPASGELTLRLHDFADDKRCEGVNDLHVSIPYSELCIILGEAEDMVPLAKIDSEEKKIFDLESSPSKPDEDLYPEDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPM8</accession>
    <name>S0EPM8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437471.1">
        <property type="nucleotide sequence ID" value="XM_023570346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPM8"/>
    <dbReference type="STRING" id="1279085.S0EPM8"/>
    <dbReference type="GeneID" id="35404908"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11446"/>
    <dbReference type="HOGENOM" id="CLU_1204808_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485882" evidence="2">
        <location>
            <begin position="17"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="260" mass="28809" checksum="36D866158C2E495B" modified="2013-09-18" version="1">MRYSYTLIAFAATALALPTAIPADDGSWAPGKYEGGDTGKDDGKWAPGKYEGPGTGFDDGQYHPGKDGKKAKRYDDGSWHEGKYEGKPGTKYDDGKWYPGKYPGGKEKRNDDGSWHEGKYEGGKTGYDDGKWYPGKYPGGKAKRNDDGSWHPGKYEGKPGTKYDDGKWYPGKYPGGKEKREDDGSWHEGKYEGGDTGRDDGKWEEGKYEGPGTGFDDGQYHPDHKAKRNDDGSWHEGKYEGGKTGYDDGKWYPGKYPGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPS7</accession>
    <name>S0EPS7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_11703</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437716.1">
        <property type="nucleotide sequence ID" value="XM_023570632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPS7"/>
    <dbReference type="STRING" id="1279085.S0EPS7"/>
    <dbReference type="GeneID" id="35405164"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11703"/>
    <dbReference type="HOGENOM" id="CLU_044863_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012610245" description="Pectate lyase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT75670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="240" mass="24928" checksum="1FD8028960259782" modified="2013-09-18" version="1">MKYTAILALAGVSSAAVTKTLPKSAGATSFPTAVPVKGSYDGGMKRFERSPSVCQGQTETGEKDAMFILENGATLSNVIIGASQAEGVHCKGTCTLNNVWWADVCEDAITLKQTSGTSYINGGGAFHASDKIVQFNGRGTVQIKDFYAEDYGKLVRSCGNCKDNGGPRNVVIQGSVAVDGGVLCGINTNYGDTCKITSSCQNKGKYCDRYEGNSSGAEPSKIGSGPDGKYCTTSGVTTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPT8</accession>
    <name>S0EPT8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437771.1">
        <property type="nucleotide sequence ID" value="XM_023570697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPT8"/>
    <dbReference type="GeneID" id="35405222"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11761"/>
    <dbReference type="HOGENOM" id="CLU_727719_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="380" mass="42614" checksum="1F635FA13D62AEBB" modified="2013-09-18" version="1">MDDGDFDLDRIWGVGPEFGGKSGSESESTCFGRRDAPASGHNSRIHETNVGRESKPLDPLLRGARRCASIVIWILTTRIVLYLVGLFLAGAAVWICLLYLLKYFPSLIANGTAFCLVNVLTGIETVAGKVFTTATPANNYQDMASFTFRRPIGLDESEVVPYVLQTTWKSFSIEFPEQAPTLKHDYDITFGNYQVLLGLNGKFVNGMEDKTIRTYSRIVALIDQISYDSDDTTKSAPWYSFRSVDQYRLQRARQSRQNLAYIIQDAIEDVEEQIRAIKKATRKCSESGPGLCNKLKPFPDTSWMARDIVAATTVCCKAQTGSESQWKQVEKTLGNFVRDLKKGLGRAESIGDTNSHQYIFKQLKKIAISMKEKCEKFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHP8</accession>
    <name>S0DHP8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423572.1">
        <property type="nucleotide sequence ID" value="XM_023578005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHP8"/>
    <dbReference type="STRING" id="1279085.S0DHP8"/>
    <dbReference type="GeneID" id="35395513"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02030"/>
    <dbReference type="HOGENOM" id="CLU_043982_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38632" checksum="42EEF57EFA2792C3" modified="2013-09-18" version="1">MGATEPQDELTRRRERGRRSQAAFRKRQAQSNNALADQNARLKQGIQRLLDAAQGDERPEMLDIFRELAVAADIEAPPRVSQMERACSSTGVSNSDITTTDVNSFQGLFSNISLPMIPSQPTQYRLECSMWLDPLHYLRVSLPPQDILPYLGAGAETFAGLLFWSVMEHYQTVCTQHNAKTVIQKGLKHSKATQDIKPSFIETMAKARVEYKQTGSISQAHAVAAEKDLGLVLCNLIETEYRSTGKDPDQWLSCIGIEKRLRKTVSHDELEDMRNAALGRENTILHHRLEDVKCRLYDSCVCFGDGPRWDVKTVDELFAPFIRCRGEANMFKRKEALCCDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DID9</accession>
    <name>S0DID9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424240.1">
        <property type="nucleotide sequence ID" value="XM_023580083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DID9"/>
    <dbReference type="GeneID" id="35394801"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01316"/>
    <dbReference type="HOGENOM" id="CLU_826534_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="395" mass="42744" checksum="A4454220C3F28EF6" modified="2013-09-18" version="1">MATSLQSHHGKDCRADKAYYECSYFDFEFKGCCSHDPCIRPRGCRDDDSSDHGSWLTRGMSDTESSASEATVIESVIDVRSAVGSIFTASFPSDDSDTESTLVTRRRPSSHTSMDDDTENDASPRRHTHSKTMTDSGTTRTIPNSIRITVTKNTVIFTSKLPSSSTSIQSITETAVDTVPTASFQSTPAQSPTETEASNLSADDSDSGGPSIGLIVGGVVGGVAALALIVLVVVILRRRKDTDEQLDSADMPYNNFDEKEEKSYLNRVLSRKANKGSTDPFAPFGGRIDRVDDPLRPPPGTFEMDATENVVHELPTATFSDAQANESQPGGHAAAGQPDRPFQNGPAAAAEYPPATMYPVDPRANLNATLEDRQQKQFVNHWNQYKALGEGEHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DII4</accession>
    <name>S0DII4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to alpha-L-rhamnosidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424330.1">
        <property type="nucleotide sequence ID" value="XM_023581205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DII4"/>
    <dbReference type="STRING" id="1279085.S0DII4"/>
    <dbReference type="GeneID" id="35394701"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01216"/>
    <dbReference type="HOGENOM" id="CLU_007933_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF4">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484968" evidence="1">
        <location>
            <begin position="21"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="404"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="3">
        <location>
            <begin position="754"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="831" mass="91141" checksum="8370066887012DC3" modified="2013-09-18" version="1">MRPFKAIIVSLLQISSASLSASISTPRPCRNVAPSFWPDGIAVDTSYNPKTSKLSSFTLNSKSRVATVDYGTERAGLPFFEVLDLDKPIQVELRFSEAFIYLKEPWSDGPYLFNTGQANSFRVETFNITQPGCYKSRFVQGGQRWQALRLLTDSFVTIRNVGLESTINTVEVRDLPGAFSCSDNILNDIWKLGARATIDSCLGKSTQPAVWQIDPNNGAYVANQRPAMTIEGHSFANYTLEFDAFIDRGGLWWAVAQPLALDGLHIQLTGEMPSRSSFANTNNTVTPPNTLLLASGFGFVNQTTLPSYILASTKIPFSVKEKTWYRIKTVLGGKGKLEISVDGREVLKVDLTNYAPGGKPVSTIGPFGFGAWQDQAAYFRNAIAYDTENKYVIYRNPLTSPETLVEYGTQENLGTVCLDGPKRDRLVWLGDFYHTSRIIGASTGGFNYTRGTFDFLLQTQIRSGQIAIAPYLGYDPTKTGTLSLERVYGLDDYQLLGFLAFAHYIRQTNDIQYARKTWAQWEKQLSWLASNINSTSGLADFGFTFLGAAQGGSLGSCATVETLNAAADIAEAIGKKTSSEYRKLATDLARSINQKLWNKSLGTYGYALGDLNTSSVAGTAFCLSSHVASKERAVSAVAALDELELGLGYKDRSTLDDHDTETKISPNTNGLLLQAIMAAEDWGRAAKLIYNVWGAMLKDPETRSGASWEYLTPAGQPGLGAFTSLGHPWGGAATYILTEWVSGLRSADGVQGFGYKNWVVNPELGAHMGLSHARAKVPLYPSGELEVKWSIKSKKMSVQIKAPPETKGVFWIGKTKKTLENDSSYRFTIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ44</accession>
    <name>S0DJ44_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase lambda</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_01145</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424396.1">
        <property type="nucleotide sequence ID" value="XM_023581994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJ44"/>
    <dbReference type="STRING" id="1279085.S0DJ44"/>
    <dbReference type="GeneID" id="35394630"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01145"/>
    <dbReference type="HOGENOM" id="CLU_008698_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000001">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 21" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="173"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="115"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="272"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="18">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT62315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="808" mass="91787" checksum="6813917F996976F8" modified="2013-09-18" version="1">MTSLQEKTAFFDQLKPLSSDDELDTDQQKERMRSRRFFAVKARPRPPAKESVVLDLTNIEAQKSRVTPRRVTSLPTPAPADRTKIIKGTPMTAIGQKTRLGTLMNQRSAGAILVDDTPIPDSTRQTRRSLPRSGSTPLFPSGRNLGQTVSDSPSPSLAMKKRKRENTINLKPESEQIFKGLTFHYIPDDDVAPARRLRITKAREFGATWVRTPRIATHIVVEKHIQYKDIESVLKNTNRNLPPRVVNEEYPIDCIQFKSLLQCSQKRYRLTGQPIAQEEDNSSPVPSSSGKPNESLQVKPHHRNSKKWDFVPLTGTPERSEESPHHSQVAETPVPTDSQPVVLDLQGMASSHHTSSERPTISRQNSTIFVQEPSGSMQNPDEDRHKDELSEYIKIMSEYKDLPLDADDDDVQTVTEMADLEFEEQSLSGSEGERANKRRSRRKIRSDHKDIAFEDRFSCNSAGVKDAKAGNPNSRTIEVLQSMADYYTRVNDHWRTTAYRKVISTLKRQEMKITTAEEAQRLPSVGPRLAQKIAEIVTTDRLQRLEYAQKEPMDEALQLFLGIYGVGNSQAQQWLAQGFRTLDDLKTSAKLSPNQLIGIEHYNDLNTRISRREIEALGAIVRRSAQRVDPQVELIIGGSYRRGAETSGDIDFIITKPNTESSAELRPFLDSLVQLLEAEDFLVARLASSRSVSDGSKWHGCCVLPKISGFNEEHYRPVWRRIDFLLVPESEMGAALIYFTGNDIFNRSMRLLASKKGMRLNQRGLYKDVMRGPQRVKVREGELVEGRNERKIFDILGIKWREPHERWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJN6</accession>
    <name>S0DJN6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424602.1">
        <property type="nucleotide sequence ID" value="XM_023569652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJN6"/>
    <dbReference type="STRING" id="1279085.S0DJN6"/>
    <dbReference type="GeneID" id="35394409"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00924"/>
    <dbReference type="HOGENOM" id="CLU_023111_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494909" description="Acid phosphatase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="49948" checksum="9F3A8EF3637ABE6D" modified="2013-09-18" version="1">MHAKPLSLLFLSSLPSLAATEDVLGLYVFHRHGDRTAKAWKPVNFTALGADEVHSSGSWYRDTYVSKDASRKITGLSPESAVLSQLDVTSPVDAVLQNSALVFLQGLYPPTKQFETLANGSKVEAPLSGYQYIPIASVETAASDRNSENSAWLQGNSGCTNAEASSNDYFSSSEYAGVYKDSESFYQGLLPVINGTYGKDEANFQNAYTIFDLINVARIHNSSISSDDLLDEPTLEKLYNLASIHEWNLAYNSSEPVRAIAGSVLAGQIIEALEPLAEGKKGPKVNIQFGAYAAFMSFFGLAGLDKVSSDFKGVVDYASSMAFELVTNATNPTADDVSVRFYFANGTAAQHTPKMFPLFGKDETTISWKDFKTGMSDFAIEDTKHWCKLCGNNDGNCASSSDDDSTSPQSSSGGSGNGVSKLVAGVIGALVTLVVILGVQAAFLLLGGLRLVKKSTLAAAGASQAGAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJR8</accession>
    <name>S0DJR8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3 8">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_00833</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424681.1">
        <property type="nucleotide sequence ID" value="XM_023570663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJR8"/>
    <dbReference type="STRING" id="1279085.S0DJR8"/>
    <dbReference type="GeneID" id="35394318"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00833"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="12">
        <location>
            <begin position="94"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="10">
        <location>
            <begin position="152"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="11">
        <location>
            <begin position="599"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT62600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="719" mass="79733" checksum="C44C6ADF36AC962B" modified="2013-09-18" version="1">MATAVEQPQVPQELRTSAPESLPKSAIPAAVASPAPAPAATETVSLRAEETPASTQETKAPVVAEAHLVDTYHPPQRMFAKHPHRPHLANLEEYKRLYKESITQPEKFWAERARELISWDRDFQTTRSGSLLNADVSYFNEGRLNASYNCVDRHAFKDPDRVAIIYEADEPTEGRNVTYGELLREVSRTAWVLKQMGVRKGDTVAIYLPMIPEAIIALMACVRIGAVHSVIFAGFSSDSLRDRVVDAGCKVVITTDEGKRGGKLIGTKKIVDDALKQCPAVENVLVYKRTGSEIPWTSGRDFWWHEEVEKWPNYFPPEPVASEDPLFLLYTSGSTGKPKGVLHTTAGYLLGAAMTGKYVFDIHEGDRYFCGGDVGWITGHTYVVYAPLMLGVSTVVFEGTPAYPNFSRYWDIIERHNVTQFYVAPTALRLLKRAGDEHVRGKFAHLRVLGSVGEPIAAEIWKWYFEVIGKEECHIVDTYWQTESGSHVLTPLAGITPTKPGSCSLPFFGVEPALIDPVSGEEIHGNDVEGVLTFKQSWPSMARTVWGAHNRYRETYLDVYKGYYFTGDGAARDHEGFYWIRGRVDDVVNVSGHRLSTAEIEAALLEHHSVADAAVVGIADELTGQAVNAFVDLKEGVESSDALRKELIVQVRKSIGPFAAPKAVYVVPDMPKTRSGKIMRRVLRKIVAGEEDQLGDITTLSDPSVVEKIIKAVHDAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK00</accession>
    <name>S0DK00_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to NGG1-general transcriptional adaptor or co-activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_00496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424985.1">
        <property type="nucleotide sequence ID" value="XM_023573227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK00"/>
    <dbReference type="STRING" id="1279085.S0DK00"/>
    <dbReference type="GeneID" id="35393981"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00496"/>
    <dbReference type="HOGENOM" id="CLU_016102_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="636" mass="71628" checksum="9756BC377FB978FB" modified="2013-09-18" version="1">MPPGASQKGTGKKNSVIPKQSRNTTPAPVATASLPPQEFYDPDYLNTRVILFRNLTYDDIVDQSASNATIPDSKSLDGMIERLKSLSNIMEKRSTFYDRGMRHLADERKKRPSEDYSNRDNEQEGKRPKHKRKKPDSLAPQEGNVERSSPMRDSKTRKHDRDPSSPLSPTHAGSPSAMDVDKKAKTEEKEGEEEESSSEDEGAPPRREQPQAMTFGEDPSTFPDPTIYEIRATYPGMPDEERKEIYSVATYPPSDLADLIAGDPPDKDFSNAKPNSQINFSTFSTYVEPFFRPFSEEDLAFLRERGDRVTPFVMPKRGKRHYTEIWAEEDGAMSIDTPQQGRDKLPPNQPRGSIDNMDDDVGETDKLSVGPWLTRLMQTLRPEARAQSADDKPTTNGTTNGDISMNGDADVEDKPASSDDKPNQQPAAFMPESSTEAWKKASHPKLEYSQVDERIKQELRHIGFLPLDGFEAEYDGHFDDEVAARLRLLQNRLKEQMLINGARKARLTDLVRERMAYQEYQTILEDLDGQVQAAYLKRTRTMGKSKKTKRPGGAGGGSHFVGGAAGTARPGIGDLTKTLMERRKRWIDTIGSVFDDESLRKVPRITDPESSIFKPADMSELMNKEKEQWDEEVEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKN7</accession>
    <name>S0DKN7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to TIM barrel metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425061.1">
        <property type="nucleotide sequence ID" value="XM_023573320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKN7"/>
    <dbReference type="GeneID" id="35393899"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00414"/>
    <dbReference type="HOGENOM" id="CLU_064039_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="16"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="296" mass="33445" checksum="C3042B19E1CDB696" modified="2013-09-18" version="1">MTSSDLAQRIPPDSWDSHMHIVDVENYTLDASAKYRPTSHSLDQALAFETSVGLRNIVLVQPSIYGLDNSCLLDGLRALGADRGRGVVAIDPEAVKEEELRSWHELGVRGVRLNILSNELAIDAAELERQLMLYANAVRPLGWVVQVYVPMDMVTLLEHIIPKLNVKFCIDHLGQPPLNKYAGADPYDIPGFSSLINLLKNGQTYVKLSAAYRMSTLPDYRDLDLIAKEVIRVAGKTHVVFATDWPHTRFEGLNIKPWMERVLSWCSDDEHLKERLFRGNAEDLWDVQRPSMKADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL52</accession>
    <name>S0DL52_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425201.1">
        <property type="nucleotide sequence ID" value="XM_023573488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL52"/>
    <dbReference type="STRING" id="1279085.S0DL52"/>
    <dbReference type="GeneID" id="35393748"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00263"/>
    <dbReference type="HOGENOM" id="CLU_060131_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="237" mass="27289" checksum="712D061B6F50F7CA" modified="2013-09-18" version="1">MSEIVLRDAYYSELPEIANVMSKAFWGDNLFGDLIHPHRNEYPDDVDLYWLRRARVNFWDYRWKWLVAVAKDQNGEEVVAGIAQWARLGEGGKRFDLRFYDPRNLLKPLSSVAMKIHAWAIQSRAVDPKEEDIIERAYPHFDSIWSGKRAESWYLEALAVHPDFQGKNVGRKLVQWGLDQAEAEGVCASVVSALGKDDFYRKCGFDEQFGTAKDGEGNPLADVEGSNIFWKWPESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLP0</accession>
    <name>S0DLP0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424373.1">
        <property type="nucleotide sequence ID" value="XM_023581728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLP0"/>
    <dbReference type="STRING" id="1279085.S0DLP0"/>
    <dbReference type="GeneID" id="35394654"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01169"/>
    <dbReference type="HOGENOM" id="CLU_018148_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023:SF1">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="690" mass="76204" checksum="7DB1E6D901EB65E0" modified="2013-09-18" version="1">MPAMWDSFKTGTGPSIHQQPPRELKNRPFLRQTQSSSSSQALPQNRSTTSVNSSNGRNSNKSRDSNYDNQTYLQDDFENRLNGLGIQNGPFRYEIRRGKTVRQPYSAGPPRLSPALGSDDIRANAPPRNPRKGEDDSPWRPASSVYLDDEFDSSKRHSRHLHHRLSRSKAPAKDMYGRSVEISPPSSPEFDAARYEPNSQDVSPIDESPNLSQLDLLGERRLTPRQSQTHLRSQIPTMRRDKPTSPGQPSPLRTTRSTDQLADITTPWETMEPPASSSDMPQQTFGLTTVVTGPQRTTSGNPSPSLGQRIRKFARAKPEPVNTRPPWNGASGRAPMVDPVRDDLTVAPLSLQRRVSKRVGLGRDPSPETPSGNAGTSRRLLPSRSTQNLKEAYKTPSPELISHSYPSPPNTGSPPSQPAITHAAAAPMLNPNMVPDQLKAVKRKPSPSSHNPHTSWSSSVYSAMTEDTLLGNKPAISSMGPGSQSTPVDLWVQPTSRFSVTTCNTAAVAAAETPRLSDSESQASPPDTPKQQPSVMDRRRPVPGGDNFRRASNVPIIISMKSASPSNDRPASIISTDKALPPAPPEMQSANDRVAYLTARLDSLAHRRNNINKSIKQMTELMPTDRLLSNTDVIRKREIEKKKVEGLKEELAEIQREEHDLGLKLYRANKRLEREAAFEPSSLWVRRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM37</accession>
    <name>S0DM37_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425577.1">
        <property type="nucleotide sequence ID" value="XM_023570807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM37"/>
    <dbReference type="GeneID" id="35394305"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00820"/>
    <dbReference type="HOGENOM" id="CLU_1875608_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="162" mass="17276" checksum="2B3AF778100365B1" modified="2013-09-18" version="1">MPTGRSKNPDLTSRSERLCCEPLVGVAWNRRQGQAFHPAKPPAVCHGFLHTKSGANQILAHAVDERSDIQDGMVAENAGSRNGHELRARTSIATNEHYSQGCWGAASAELSHHQPLDGSTVPVIINASRLQVLSCAREAISNGLEGRPGVAAARINETADNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNE0</accession>
    <name>S0DNE0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to pisatin demethylase (Cytochrome P450)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425003.1">
        <property type="nucleotide sequence ID" value="XM_023573255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNE0"/>
    <dbReference type="STRING" id="1279085.S0DNE0"/>
    <dbReference type="GeneID" id="35393958"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00473"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="415" mass="47001" checksum="9160EA804FD2FFE2" modified="2013-09-18" version="1">MSAVRSTYTKGDFYSSGRIVPGVDNVVSERNEAKHKFMRAKMAPGLLEYSYRENEGFGFEAGIDRQLLRFISLIDRKYLSTTSQSRPLDLTEKTQFFALDVIGDVSFGEPFGYLIKDEDLYQYNKINASSLPVMNVVSVYPWLGRIVHRWPLSLLLPREEDQVGFGRLMGFARHLVRKRLAEGVTMRKDMMQMHISNGMNEEELIQQAFISIIAGSNTTAHALRMIILSLITNPSAYRSLIAEIRGVTSTVGTPISWAQTQTLPYLQAVIREGLRMWPPVAGLGFKQVPPEGDTINGFFVPGGTQVGQGFYAVGRSRLVWGDDADVFRPERWLLADEDRLRDMTAALDTHFGHGKYSCLGKPIALMEIHKAVFELFKRYDFAILNAERPIKTQTSVFLFASDFWVTITQRNDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNI3</accession>
    <name>S0DNI3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426220.1">
        <property type="nucleotide sequence ID" value="XM_023572012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNI3"/>
    <dbReference type="STRING" id="1279085.S0DNI3"/>
    <dbReference type="ESTHER" id="fusof-f9f132">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="35398155"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04674"/>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005146069" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="23"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT64139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="531" mass="59845" checksum="E91FA940E0B64368" modified="2013-09-18" version="1">MSISFFLLTALAWTTSAASPKATTLNGTYVGKNLPDWDQDAFLGIPYAQPPVGNLRFKWPQSLDSSFTEERTVTEYGDSCMQYTQNWTMSEDCLSLNVIRPAGKPKKLLPVLVWIYGGGLYAGSSADPQYNLSGIVKVSQDIKEPILAVSFNYRLGMWGFLQNFSLLKEGNANAGLLDQRLALRWIQENIEAFGGDPERVVVWGESAGAQSIAYQMFSYDGRDDGLYRGAILESGGITGAQIHDLSYYNVAFENLTRTVGCWDKKDQLACLRDLDEKSLYAARPSLTFNPLIDGTFLTGYPSQLIREKNYHTVPLIIGANTDEGFCIGKVNTDQDLFYEAFRWRNYALSAPTIRKLMELYPDDPCHQPPYAITDCSRQDGNYQGRRACAIGADITMISGRRKLAELYAQSEDVYSYRFDQRPYLRSEWDGVKHFDNVAFSFQNISGLLGPSPQYDSHAVLANTIGQAYVRFVNSLDPNSKKGKLPKWPKYSKSKPKNMVFNATKNWVEDDTWRKQGIDYINSYEVARELYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNR6</accession>
    <name>S0DNR6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04764</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426136.1">
        <property type="nucleotide sequence ID" value="XM_023571911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNR6"/>
    <dbReference type="STRING" id="1279085.S0DNR6"/>
    <dbReference type="GeneID" id="35398245"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04764"/>
    <dbReference type="HOGENOM" id="CLU_027444_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="259"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="323"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT64055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="517" mass="58939" checksum="FB0E8374C28DEFAB" modified="2013-09-18" version="1">MSMDLDDQPISIAPASQQQGAATILCCNCGAPIDGTASSGALCYDCIKLTVDISQGVQREATLNFCRDCDRWLMPPNSWIVAAPESRELLAMCLKKLRGLNKVRIVDASFIWTEPHSRRVKVKITIQDSVQDGMLLQQSFEVVYVVAYQQCPECAKSYTANVWRAAVQVRQKVLHKRTFLFLEQLIMKHGAHKDTLNIREAKDGIDFFFAQKNQAEKFIDFLNSVVPVKVKASQELISHDTHTSKSSYKFTYSAELVPICKDDLVALPIKMAKQSGNISPLLLCHKIGTSVYLLDPQTLQTCDISSPIYWRAPFLSLTDTHELVEFIVMDIDRTATQKGKWTLAEATVARASDLGSNDRTYFTRTHLGRLLQPGDSAMGYLLAGTVFNNTEYEKIESSNTYSSRIPDVVLVKKHYPRRRKNRKRNWQLKRMDKDEGELLPKKADQERLDQEYEQFLRDVEEDEELRATLALYKAKKRAEEEMSVAETEEDDEAPHVDMNELLDDFDELTMEDRPMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ23</accession>
    <name>S0DQ23_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to Nap1p-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424754.1">
        <property type="nucleotide sequence ID" value="XM_023571563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ23"/>
    <dbReference type="GeneID" id="35394237"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00752"/>
    <dbReference type="HOGENOM" id="CLU_024803_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000283">
        <property type="entry name" value="NAP1-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="296"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="503" mass="55093" checksum="EDE32D5589327E93" modified="2013-09-18" version="1">MSTTSSPVTSPSAAVSSSPNPNHPALPPLITSPPSRRSIQSRPMSHVSRSRLSQYSTGSLPTRSRPTSHMFPMFPSTLSYTQVRDFAYPATHPLHYGPPPEPSGPPSGMTTPASEHRRLSDPPVSWETRMPWESWGTDGFNRGHDLAPIQFDGGPPYSEDEDLQSPVVATRHRKHKSTSAATTLRGRTGRDLDMHSSNYDRERGYYMGTSGDGSETYYVNNGGEANGPGGDFVTYPPEQARHSRAYHIAQQPRAAEGGEYYQPESDSSPSSPGYNDEDQSRYSRDYQFTITSPDEEFHGKAVALFDFERENENELPLVEGQIIWVSYRHGQGWLVAEDPKTQESGLVPEEYVRLLRDIEGGMNSLAGHLVEGTGSPDVGTPTQAEHSGQYGHTPSSSNATNGYHQPIVSMFSTSSKDLDPYPTEQLGLHSGQPPPQVIHYHGQRGGSQANTPTIAQPQDTGILRRESHDGGTKRDSNVTPVQAKPPMELVEPGGCEEARGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ32</accession>
    <name>S0DQ32_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426621.1">
        <property type="nucleotide sequence ID" value="XM_023572512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ32"/>
    <dbReference type="GeneID" id="35397709"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04228"/>
    <dbReference type="HOGENOM" id="CLU_1390296_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="200" mass="22380" checksum="902D8888C7411001" modified="2013-09-18" version="1">MSTCLSGVLSRSELWTIQTQGTIDVNLSITVDERNGTDHNQSPPRKRPKTTHFGNADNVHMRNAEPRTGELQPFTSVGNHSTSGQHDTESKEIDYAGAIRKECAGMEMDSNHRFLYVVPGNGVVVFFQGMNQAAATLDKDYMAKAFEMVTFQFDSSRTMRLFAELLKAHFENYSGVMPRVHAKVLVFESASFPEAPFLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQB7</accession>
    <name>S0DQB7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">FFUJ_04119</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426721.1">
        <property type="nucleotide sequence ID" value="XM_023572633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQB7"/>
    <dbReference type="STRING" id="1279085.S0DQB7"/>
    <dbReference type="GeneID" id="35397600"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04119"/>
    <dbReference type="HOGENOM" id="CLU_027506_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484819" description="Crh-like protein" evidence="20">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="21">
        <location>
            <begin position="21"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="277"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="339"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCT64640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="419" mass="44041" checksum="6896C9A1743F9BD7" modified="2013-09-18" version="1">MFSKAFTTATMALACAGMVSAQTFTDCNPLKKTCPADPAFGDNEVDCDLAKGACDAFHGMIGTELKYSDRGALFRINKESDAPTIRSDNYLFFGRVDVVVQAAKGQGIVTSAVLQSDDLDEVDWEWVGGDDAQVQSNYFSKGDTTTYDRAQYHAVAAPLTTTHKYSIEWTSTKIDWLIDDAVVRTLNAADAQGVNGFPQTPMQVKLGTWVAGGKNSNEGTREWAGGYTDFDDAPFDAYYRSVTIIDYAGKDAPGQNKGAKQYVYTDKTGDWTSIKVEKTSSDNDDDKTSTSTTVSKVSKTTKTAEATTSAVETTSAHESKTKSAEKESKTESAKETKTSEVATTFATATSTKAEATATATEGSGSGSESDAGAGAATATGSGASPSEPATTPVPVNSGSRMAGSVVAAFAGLIVAQILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQF7</accession>
    <name>S0DQF7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_00621</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424874.1">
        <property type="nucleotide sequence ID" value="XM_023573018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQF7"/>
    <dbReference type="STRING" id="1279085.S0DQF7"/>
    <dbReference type="GeneID" id="35394106"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00621"/>
    <dbReference type="HOGENOM" id="CLU_008177_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="462"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="495"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="833"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="504"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT62793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="968" mass="108212" checksum="C6B0FE0BE3BCE65D" modified="2013-09-18" version="1">MSQPQDVASPVAQHHTDTEPEKHEQQQQQQQNTHEMFEKQDGPEVHDEKETTATTEDKQEDLDMHKTDEDSIAENHEDKAEDKHEEKPKESNDKPEGNQQDQLSQNDTNVKRLSSGTESDDTMSASDADDKFEDAVTQSPARSLTKRNISQAKRRDSEAEERTDRRSEESHQQEDTLDTKITQHKATGSEAGSVKGKQSRRKPSIASTRISNTSNLDNVSLDDDTPPSPVPKDLPPKPNSKTISLNSISLPSMPWSPAADTSKSPVPSTATLAPTPPVPQPPPPPSRKLTSPFSWLSRSSSKEREPPLPPPPAGRRNTAGSIATLSSNPEMMLSRLEEEKDGDSLPGDPAQRVTLKDRFKQLRQQEEAARAMAEGDSSKYDGALGLTLPGDEGQPQEKPPSSPVPQPIPGLAPGTVAGVNAGPSAISEEKVDWDLWQSVVYEGPAAVARTSAEELNKAIATGIPSAIRGVVWQVLADSKNDDLELVYKDLVARGTDKSKDRHSNSTTASSLSNGNLSVHSGDAVTSSASSINSDHSGTNGTPSPNEKSAEAVLKAQAAAAAERKRKDKEDAATLQKLEKTIRRDLGARTSYSKYAAAAGLQEGLFGVCKAYALFDEGVGYAQGMNFLIMPLLFNMPEQEAFCLLVRLMNHYKLRDLFIQDMPGLHMHLYQFERLLEDFEPALYCHLHRRGISPHLYATQWFLTLFAYRFPLQLVLRIYDLIFSEGLSAILRFGIVLMQKNASILLGLSDMQQLTTYLKDKLFDVYIDKDPSHGSLLENGFFGSSSSSIDKEVYRADQLVKDACEVKITPEMLKSYSTEWEEKTKAEKDRENELLELRTSNHNLSIQVRKLEERVEVCDREQADLATELVHTKVENQELKDENDSMRGQVRELKIVIEKQPMEIEETWKLERDDLMKRNMHVHEENQRLEKELSELEEELVQTKLRYAEINSQHETLNRKWTDLKRQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR74</accession>
    <name>S0DR74_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to transcription initiation factor IID 250K chain splice form 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427125.1">
        <property type="nucleotide sequence ID" value="XM_023572708.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DR74"/>
    <dbReference type="GeneID" id="35397533"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04052"/>
    <dbReference type="HOGENOM" id="CLU_000572_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="415"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="755"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1163"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1209"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="759"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1179"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1209"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1247"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT65044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1301" mass="147457" checksum="52F5114DC6883518" modified="2013-09-18" version="1">MAEENDFSSFDENAWKAQDAADDREIAKLLGDSQNNGGGIVLDNVAFDQSGKADDAEDYEDISDDDLPDEEEPSAGVSMEMPGLTDDGGTSHDPDDLFGEGPSSPDPILGPSSPAPHIRDADTTDDTQPLDSSLSFPGINFDPEPHLDNQDHDIPAPAETVEDLLKATWPAFKKGHILTWSELLPAKKATWKEKKPVKKPKQLVTSKLTLELAPDQEKLFRIPGTATVTRKPRQGEERGLVYCGMDQEDQAEDNVQFDLDQESDSETVAGFTLRDIELACEDWGASIEAIEADFKARQAAEQQEQQARKRVFEEQDDEWDAEFLMDLGDDGPPRPKKRKTVKLGLPEIPRYAAPSFDNFEDATRRGAKRVQLDMSDPYLLIETQETQRNAKRPRTDNKLKRMANGNLGRDVSNRFNISNDEAYEALKENHQSKVRATLGNISVEHSMPAIKLSWPYYKVKLGGTTDEYHRPRFRYKKFAGHIIKFDKPAHQKRKQMKGKAHEVFLKSRDLSINDNSTAVLYEYCEQRPRVLSSFGMGNRLINYYRRKDTNEDEQLPKQELGEYRMLLPEDRSPFSLFGTVDPGETVPTLHNEMYRAPVFKHNPRGSDFLIVRSTTGEHGSRWFLHKIDHLYVVGQQFPSVEVPGPHSRKVTNASKNRMKMLAFRMIRHSDTDNCQLSDITKHIADSTDTQNRQKLKEFLQYDRESGEKGMWRLKPGEILPDESTIRSMIKPEEVCLLDAMQLGIKELEDAGYDPRNASLEEDVQNNDADGDDDDVEDEGSKITKGAKKQQEKQEETLADKMAPWKTTKAFIDACAQKAMLQLHGEGDPTGHGLGFSFIRTSMKGGYIEAVQGPLATSADAMEREKRANGGHAYNVKKQQAMYEEGIREIWEKQKSTLSDGQEHDDKDVAVTEDEDDRFNVQSAMTPAQFDDGTSQISGLTSASRQQRRAIRITREIRMPDGSTQDRVEVVHDPVVISQYMKRRTEADLEMREYVHPPNNSRQAVQQPQSRGVVTRKRRRTYGVGTPGSRNDIAGLEFRAPAYVYLSTASTVPVLQAMPTMTVLQALESRRSSNDSRRTKLDDRLGSNKKSSTKRPAQEMSGHPVSMAIKSQLEQPASVPIVAKLVTSRQTRSMSPHSPSSLPFVSPPSPMSFNWCAPLEVDNAKRSRSRKSRLQLAMEQCDKGKARDAKKRAEEKARADKAIALQLQRERRAAKKEAERKLRDAEAKRQQEEREAKARQAQQQRAAKAREKAEKKRVKEERQRRNRERKAFEEEIVRARREAERIRNAWKVPKWRSGGAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRB6</accession>
    <name>S0DRB6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bys1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427076.1">
        <property type="nucleotide sequence ID" value="XM_023573059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRB6"/>
    <dbReference type="GeneID" id="35397216"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03735"/>
    <dbReference type="HOGENOM" id="CLU_144311_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484436" description="Bys1 protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16516" checksum="E46E41373EE231B8" modified="2013-09-18" version="1">MKFAAFTALAAVFGSAAAANKANVINDCTNTIYVQSFPYGGGAPGPLTTVKPGQRFSEDLRASGSTIKIATTRTLTKPLFFGYSSESQPNNVYYEFSTEYGNPFADKHNILSPGEGCEKFDCKANDAKCYSTPSMKKVYGCPSPVNLYAKVCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRG3</accession>
    <name>S0DRG3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable nucleoside-diphosphate-sugar epimerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426078.1">
        <property type="nucleotide sequence ID" value="XM_023571839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRG3"/>
    <dbReference type="STRING" id="1279085.S0DRG3"/>
    <dbReference type="GeneID" id="35398308"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04827"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="302" mass="33352" checksum="1F187F6D2D57DD13" modified="2013-09-18" version="1">MSRAILISGATGKQGGAVLNQLVKQRAGVEILAVTRNPNSPSAQKLLKKSSNIKLVQGDLSDAATIFKNARQVTKQPIWGVFSVQSPMGQGDGAEVAQGKGLVDAALDAGAKFFVYTSVDRHGQDSLNNPTQVPHFITKHEIEKHLISRTTGTDMQWFIIRPVAFMENLTDNFLGKSFVTAWKLVVKNKPLQLVTVTDVGVAGAQAFLQPEKYAGRAVSLAGDELTLEEFERIFKEKTGRDLPYTYSLVVYPIMAMVKELGYMFKWFKDQGFGADLKALRKEYPELMTFGTWLETDSDFAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRQ3</accession>
    <name>S0DRQ3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Cytochrome P450</fullName>
                <ecNumber evidence="14">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="14">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_02192</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="14">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="14"/>
    <dbReference type="EC" id="1.6.2.4" evidence="14"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427340.1">
        <property type="nucleotide sequence ID" value="XM_023573893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRQ3"/>
    <dbReference type="STRING" id="1279085.S0DRQ3"/>
    <dbReference type="GeneID" id="35395674"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02192"/>
    <dbReference type="HOGENOM" id="CLU_001570_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06206">
        <property type="entry name" value="bifunctional_CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 14" id="KW-0288">FMN</keyword>
    <keyword evidence="4 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="12 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0521">NADP</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="506"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="682"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT65259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119856" checksum="5284A8FDB7024CD5" modified="2013-09-18" version="1">MAAKQESKKHDDKHKGQIPGPKGLPIIGSLLDIDLTDSLKSIIDMAKDYPKLFALNIGGNTEVMICSRELMDELSDESRFHKLVVGGVEKLRPLAGDGLFSAQHNNQEWAIAHRILMPLFGPLTIREMFPDMRDISEQLCLKWARLGSSSTIDVGNDFTRLTLDTIALCTMGFRFNSFYSNDKMHPFVESMVAALIDAEKQSFLPDVVQSLRIRAQSHFKKHAAVMKSTCQDILDQRRKNPVEGKDLLNAMMNGKDPKTGMGMSDGNIVDNLITFLIAGHETTSGLLSFAFYYLLENPEKLQRAREEVDEVLGDENITADHLPKMPYINMIFRETLRLMPTAPGFYVTPFKDEVIGGQYNVSAGDPLFLFLHMIHRDPEVWGPDAEEFRPERMADEHFNKLPKNAWKPFGNGMRGCIGREFAWQEAQIVTIMLLQNFDMVKADPNYKLKIKQSLTIKPDGFNMKVKLREGRDLTNLFKNPSLASSKQPSLSSRKNLNISQKDLKPISIFYGSNTGTCEALAERLSADCATFGFMPSKPLPLDDATKNLSKDGPNIILAASYDGKPSDNATEFTKWAEALQPGELEGTQFAVFGCGHKDWVSTLYRIPKVLDKCLADAGADRLVEIGLTDASTGRLYPDFDDWAHSKLFPELASRHGITLDHEPDSLELSVTINQSQRNDIGGNFKRAEVVENTLLTSPGVPRKYSLLLKLPKDMAYTPGDHVLVLPKNPPQLVDRVMTCFGVDDDTVLTVSSQRPTFLPTGTPILASNLFSTLVELSQTVSRTSLKRLVDFAGNDETKVEIQSLAGDRYDAEIDQQRMSILDILRKYPSINMPLSTFLSMLPQMRPRTYSFASTPEWKPGHGSLLFSVVEATEASGSSLARPGGLATNYMAQLRPGDSVLVEPRPCRVELRTAMTAELNVPVVMIAVGAGLAPFLGFMQKRYLQAQKSGHLSNSPCTLFFGCRGAKMDDICRDTLDEYSRTGVVSIHRAFSRDWDSPYKYVQHLVAKHADTLARLWGQGAIVMICSGKKVSDDVFDVLGPILHSEDRRLNTTRASDWKTWMDGVSKERLILEVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRV8</accession>
    <name>S0DRV8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_02243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427390.1">
        <property type="nucleotide sequence ID" value="XM_023573950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRV8"/>
    <dbReference type="STRING" id="1279085.S0DRV8"/>
    <dbReference type="ESTHER" id="gibf5-s0drv8">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="35395725"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02243"/>
    <dbReference type="HOGENOM" id="CLU_006586_17_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="17"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="553" mass="62529" checksum="5AD4C67AA3AC3DDF" modified="2013-09-18" version="1">MLDNYTRESYIFDAGPLGHIEGLTITSHGAPAVHYFGGLPYALPPAGQWRFRVPRRLTKHYRYGTATEPGKFTGGTRVCPQPPSSNTPDPSVISEDCLQLNIWVPAGPPPKNGWPVCFYIHGGFLQVGTSNTEPEDLVSLLSESAFRAIMVMPSYRLNVFGFLASRELAAEASSNGEATGNYGLWDQRLALEWTHENISFFGGDTANITVAGYSAGAYSTFQQLAHELFRVPEEKGIIRRVAMFSNSTGVRPKGLQDQQLQCDELLTRLGINLALSDEEKLASLRAVPYQRLVEAQTGMRISEFRVLADDTFYPIDLVNKINDGDFAKKMKNRGTRLINGECESEHIMYRHWRTPQESYSAVYQRLLADFSPEVTEKIMNHYCGSSKNLPAGYENWEDFFGRIYANVQVHYLQRGFHNALFAGGLDPGKDIFRYRLEKRLDCVAEKVPLEWGVTHLTDIPVWLWGCGYEGGLSDQEKEWLKGWNEGFAAFVSGDEVNWGTASPKEMRRWRSDGETDVWKDILWEQGVEFWKLVNSGFERTEQKANHQEHGVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSH9</accession>
    <name>S0DSH9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_00105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425594.1">
        <property type="nucleotide sequence ID" value="XM_023573664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSH9"/>
    <dbReference type="STRING" id="1279085.S0DSH9"/>
    <dbReference type="GeneID" id="35393590"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00105"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF20">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="28"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT63513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="371" mass="41334" checksum="A4CC1F6DA1B9E280" modified="2013-09-18" version="1">MPNNDCQQAPVDLVAYNASLSDEPLRKRILHQELDPTRHEYISIAGGEGFLDAARDFAFGFGDKTDQQDVARVTSVQAISGTGANHLGALLIARRFKPNNVWLPDPTWGNHYTIWDFAGVRCRPYPYYSNTTQSPDLKGMLDTLSSQASRGDAIALHSCAHNPTGTDPSHEQWERIAQVCQQLGLVVLFDSAYQGFATGDVDANAWAVRHSFHKKPSLSICVAQSFSKNFGLYGQRVGACHVALAHGNSSESPSVFKQPTHFIRAEYSMAPRWGSGVVKRILQSSELRQEWYHDLISMSSRIRLMREALYRKLVELQTPGSWDRLLSQNGMFSYTGLSPEQVLAMREKHHVYILQSGQISLSGLLCGTEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSK2</accession>
    <name>S0DSK2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426463.1">
        <property type="nucleotide sequence ID" value="XM_023572318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSK2"/>
    <dbReference type="STRING" id="1279085.S0DSK2"/>
    <dbReference type="GeneID" id="35397882"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04401"/>
    <dbReference type="HOGENOM" id="CLU_002370_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1166" mass="128163" checksum="0A474BE8FF1A8C5B" modified="2013-09-18" version="1">MTSHEAVRLRQGLLPLTTSSVGAFNNPLHTPISAVSMSSSHFHSAVQTPGSSIQPYNPQEWVPTQAAVAERAVQYAGEVQGKPPRTKHHVIASQRPMSTVFDSTPAGTPTPPPRLSTMVHRPSPEPANASFPPPPPGVNGRNGSRDRRFLPSLGRRRDMDTSSTPPPQPPPPQAHRQSMIVQTSFHQPTPEHGMTGPVIHGPPAARRAVSAGAVETPTSARSRSASQTRWEPGMPLPPPPPGPPPASSRSQSVQSIDRNTVPIISPPTKRRRPPTGVTELGPVPPTPADWNETGSQAGPSNRSRSPGLRIDTSLPSSQPVEPALGSSSSIGGLNRQKAVRHDKTILQRRAESRTRHSVRGSIDERTRPDSMADIMVPNTTDLSRTSIGKSTPLSGALASQDSRNSTPRAPASGKLPQEAETPPFSPNASKQPIYASSSKVVAPKALPTPPPRSGSVASVSRVRESSRPPSAGLLVSKHLVTTQTADQFEEGTIDRFREFAIRESRAATDADRVRMFADFVVNESRIRRERYSVAIGAMGSEIFDLTRDLFRPMVSQRRESASSQDQWTPGLSEPGPSRRGSIGSNLGESPQSASKTVNVPTSPSGNNPPNVNWSSNYMPSLSPILSMSVSENYENGSSRGRPPSRWWESDSQGEASHLGRSKRESKYMGVTKTQWVEEDQPSVVYEEQGSSSEYPPEKTGWHDQSEPNLTPQQFGFATTSNMGSSPCSTINRDHLDVSRLVTMPPPYPRHHPAVNNKHPELTSIRTAVRALSQLDELAKTRERFTVESTKRREQFSKAASERRQALRTNLQNEINAGSLSYADAGAIDADAKASEITKKKDLEKSEYELFQNQVVLPLNELLTGRISSATELFDDLARHLFDNGQIDADMPQEEGDDRPELLEKLTLLKWVFEAREGLYRAIYDLLSDRNGRYCEVVLTPYRLSGNTEKLKSAEAFFAEDAAKREYAFAHEVLERTRDFRGVVEKAVDHGVALQLSAFWDIAPPLCELLDNIPLDLDGFNIQIPASEIQENPSYVEHPMQYLFSLLLHAEKSTYQFIESHTNLLCLLHEVKEAVVHAKGKVLETQTQDENGNAIPKADSNAQAVQMRQSEERRLTEDLKEKVRLVQDQWKSALGDNITLVKERLGGWLLQMGGWDESLEDRGVGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV04</accession>
    <name>S0DV04_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427303.1">
        <property type="nucleotide sequence ID" value="XM_023573848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV04"/>
    <dbReference type="GeneID" id="35395633"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02151"/>
    <dbReference type="HOGENOM" id="CLU_153340_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="139" mass="16081" checksum="0C68A0C7F3052C15" modified="2013-09-18" version="1">MPHNISSPNSWTITPSPMESVHHNLLILKHKVDTVGDKDGPFVALFIKGSKSRARWEGWVDERLVHERDEGKLLAYWQKVGGRDAQGIRETCPARILYAHRRRENGKGTEYFVQYVGYPNDDPINQWEPESKVLEAQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV21</accession>
    <name>S0DV21_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428397.1">
        <property type="nucleotide sequence ID" value="XM_023575171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV21"/>
    <dbReference type="GeneID" id="35396817"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03335"/>
    <dbReference type="HOGENOM" id="CLU_1421513_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="191" mass="21440" checksum="7AAAD0CFF1985AE2" modified="2013-09-18" version="1">MHGSDGGMVTYLDEAISKAVQCEISPKASGFSLLVLSSWRERDRDKRQTVRYWYRTPTEPVQLRDSLPLGSGPGALPTLVHAPRRLLALVRLCLIHHDLGSSINLFSVYVVDELLLSICTCEREGRWRWDKRAECLKHLVNEEKGSTGLRVHMGALLGLEFDSGLVPGIRFGDSAVTVRTGQEEARRDKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVF3</accession>
    <name>S0DVF3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427473.1">
        <property type="nucleotide sequence ID" value="XM_023574048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVF3"/>
    <dbReference type="GeneID" id="35395813"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02331"/>
    <dbReference type="HOGENOM" id="CLU_088636_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495255" evidence="1">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="174" mass="18860" checksum="E7E8602388AB1FE8" modified="2013-09-18" version="1">MRFSLQALSLFLVSSQAGFAVAGLCKPSTTTTAAATTTTASVPQGTPIDAVLSDGSVVNTYLNDVYLSDQGNTPATFILEPTTSRLTTNIGGITYYLQTVIPLGPQLSFQFDTYQNIVNNQYRYFVKCDVVAGFLSCASESGSTPIYWHIESNNIFYGNENVLTDVTTAQFKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWT4</accession>
    <name>S0DWT4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_13137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429042.1">
        <property type="nucleotide sequence ID" value="XM_023575786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWT4"/>
    <dbReference type="GeneID" id="35406591"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13137"/>
    <dbReference type="HOGENOM" id="CLU_109888_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="221" mass="24847" checksum="BF5C21CD74E975DB" modified="2013-09-18" version="1">MCRLLKLQYACSSNGEPHYMENAQGAFIPCNDRHGCLIEDVLSLKPGSDTSPPGSPIEREYTIVKIGGDCETCANQKTRKIEEDDQVFIEMNSVVGRTERDFHGMIRRCGEIAVDNRRRMLNNVRSQYLPNDTCSSGSCQNQVYVSHAGHKGMFCRNHTCSAREFDCLTDVSTTRNSPQYSIYCPRHTCSKSGCGLQILAHDTPLCKRHHDQLELAISVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX35</accession>
    <name>S0DX35_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to ERP2-p24 protein involved in membrane trafficking</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_13311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429205.1">
        <property type="nucleotide sequence ID" value="XM_023575982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX35"/>
    <dbReference type="STRING" id="1279085.S0DX35"/>
    <dbReference type="GeneID" id="35406765"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13311"/>
    <dbReference type="HOGENOM" id="CLU_066963_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495314" evidence="10">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT67124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="210" mass="23372" checksum="E8E09FD5CBF7BAB2" modified="2013-09-18" version="1">MRLSTLVAGLFAGLVTNVAATALTYKLDANEKACFHTTTKKQGEKIAFYFAVQSGGSFDVDYVVEGPNGKIIMDGQKERQGDFVFSANVVGDYSFCFDNEMSTFAEKFVDFEIAVENESRAQLPSKQGTTPEQTSILEDSIFKVSGQLSTISRNQKYFRTRENRNFATVNSTEGRIINFSMIQIGLIICMGALQVFVVRFFFQGARKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXE0</accession>
    <name>S0DXE0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to chromosome segregation protein Cse1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_13306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429201.1">
        <property type="nucleotide sequence ID" value="XM_023575977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXE0"/>
    <dbReference type="STRING" id="1279085.S0DXE0"/>
    <dbReference type="GeneID" id="35406760"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13306"/>
    <dbReference type="HOGENOM" id="CLU_029376_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT67120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="489" mass="53577" checksum="36E2912F0FE46FAF" modified="2013-09-18" version="1">MSTHREGVNPLRPYYIPPTIGEAAETVNKSSPSPNPFPDGRHVTAAGERYASKARDILSDLEYNDYLGDTSPSMVQNVKDLIDELLWKYTSVLMAQPFEVAKTLLQVRNQDENAAYETPVEPETPKRQPSFHGSSMYGGFGDSDSEGEEPAYFTSHIPSTPSPSTPRGSHGRRAPSPVKKPNVPEHYLTLRRPDSILEVIGQLWGKEGAWGVWKGSNATFLYTVLQSLLENWGRSFLSAIFNVPDMGVREDIDRMIDIASPYPWASLFVAAAAAVATGLALSPLDLVRTRLIVTPSSNGQRRTLATLRNLPSYLCSSMLVLPTVLNSLIHPLITLSTPLVLRTQFMIDSHVSPMTFSIAKFVASSSAILLKLPIETVLRRGQVSVLSSHEYVQALSGPEQQFTTIVPPGRYEGTFGTMFHIVNEEGTHEVTSTKPAAAKKGKAKTKGVAATVYKGQGREGLWRGWKVNWWGLVGLWTASVVGHGGEGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXS6</accession>
    <name>S0DXS6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429341.1">
        <property type="nucleotide sequence ID" value="XM_023576146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXS6"/>
    <dbReference type="STRING" id="1279085.S0DXS6"/>
    <dbReference type="GeneID" id="35406912"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13458"/>
    <dbReference type="HOGENOM" id="CLU_032828_4_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="115"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="272"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="455" mass="49766" checksum="E5051CFC1FE5427D" modified="2013-09-18" version="1">MNPTPPPYEEVPQSKLLPGGTHESHQHLLPPPPSPNLLSSKVDGSSFDDFRRMSSSPSPCPSPIPLRQFSQQGADPPAETPPSKWRQFWVKNKPAAYVALSQFFGALMNLSARLVELEGDGMHPVQALLMRHSITALFCSAYMWWNKTPDFPLGKKEIRWLLWLRGASGFWGIFGVWYSMMYISLADATVITFLAPGVAGFICWFALREPFTRIEQLATLVALLGVVLIARPASLFSGSDDDKSTTEPPEASGIPDIDHEATPEERLIAVGIALLGVLGAAGAFTTLRTIGKRAHPLISVNYFGIISTFIALSMLIFAPILDIQQPGLRWVTPTTVKQWVLLLPLGVLGFIMQYLLTAGLGADKSNRANSMVYTHMLFAASFDRWVFGHRMDFISGAGCTLILGSAIGVVMLKKPPAAKQPLDDVERHGNLEGEMEGSPMLVPDSGASEELRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXX9</accession>
    <name>S0DXX9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_03259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428328.1">
        <property type="nucleotide sequence ID" value="XM_023575086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXX9"/>
    <dbReference type="STRING" id="1279085.S0DXX9"/>
    <dbReference type="GeneID" id="35396741"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03259"/>
    <dbReference type="HOGENOM" id="CLU_013364_5_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="119"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT66247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="600" mass="66751" checksum="BA56A80DA8E4567B" modified="2013-09-18" version="1">MSEKAIVEATPLLRGRLQQRPRKSHYSTILGLLAAVCLITFFHRRPYPYPVNIEDPADKPWTWSDVKPSRKLHWEPCYEKFECARLDVPMDWLAPSDDKRVVLGVIKLPAKTKNNPVSPLFVNPGGPGGSGVNFVRKEGHILQAAVGENHDVISFDPRGVGVSTPRVECWGSSQKRKLWSLQDTPVADEHPGLIFDAYARASAYSGTCEQAMEETGLMQFLGSASIARDMLEILDKTGHEKLRYWGFSYGTILGGVFAGLYPERVERLVSDGNVDYHDWFNLDHGNFVSDTDMIFDGFDKACHKSGPLKCALYADSPKAIEERRSNLLASLKKSPVLVPAWTHDSGPELPLLVTYSHLQRLIQTSIYSPLKKFPQLARVFASLEKGDGIPYYEMVMEGENKSLNGDMCELGETPATMPLETPMELDAFPAIMCLDSKPVTETPQEIADYFDRITHKSRWAGAVNSNFRVSCVGRKTRPKWKFTDADFRGDTAHPILYIGNMADNVTPLQSAFNNSAKFPSSVVLKQNSYGHCSLAAPSACSLTYIREYFQKGTLPPAGAECDSDYDLFEMPGLGEEVAGLDELSSIAFKLSREVELPKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYQ6</accession>
    <name>S0DYQ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429772.1">
        <property type="nucleotide sequence ID" value="XM_023576638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYQ6"/>
    <dbReference type="GeneID" id="35408058"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14678"/>
    <dbReference type="HOGENOM" id="CLU_057361_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485067" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="43613" checksum="C15133FFEBC8D613" modified="2013-09-18" version="1">MSSDSQSPAEVTGPTAFWILASLASAAAAQPSGNRRRDNDLFGGNVDIVRSIPAVCLIDSIFDLFVLARGISRFLSSENSTQQIRRNSPKATGLVIRLALTIFTVLPQTIKVFSLQGVPATQICAFIFFFANVTKLLVSICGWEPEGNLHDEDDSTSTDVLLSSFLQAPFEFWIWFNISRQASFKLSTGLENVCDWAAMVVSFSMVLQVVIWIAYLVARRRLDLSRSLYIVPMRGFYLVMVVLGLARQPSTRNPSRATIQPPPGWVDIFNYSSGLIICTAIVSIAITKLLESIGTLLALLLSRGSSEDEQNETSEAQSTSGEDAAEEQEDHLFAGHPGAWLGRIGVFPDRLVVRGLALNTTASTSITLTVFNLITTVFYYLVYFDGTGTANPSWTSVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E086</accession>
    <name>S0E086_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_13221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429123.1">
        <property type="nucleotide sequence ID" value="XM_023575879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E086"/>
    <dbReference type="STRING" id="1279085.S0E086"/>
    <dbReference type="GeneID" id="35406675"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13221"/>
    <dbReference type="HOGENOM" id="CLU_042324_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="75"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT67042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="392" mass="42675" checksum="9BFE3F7D818E7AAC" modified="2013-09-18" version="1">MSDIGDEMDVDVPVVSKDVIFSSEAKQGKRSAANLPVEAEDSLPWVEKYRPNTLEDVSGHQDILATINKFIDQNRLPHLLLYGPPGTGKTSTILALARRIYGAANMRQMVLELNASDDRGIDVVREQIKTFASTKQIFSMGGTSARSGNSMAGFKLIVLDEADAMTSTAQMALRRIMEKYTTNTRFCIIANYSHKLSPALLSRCTRFRFSPLKEGDIRVLVDKVVEEEHVRIGGEAVDALVKLSKGDMRRALNVLQACHASSTPLRAKDAPKVPDSEIERENITTETIYNCIAAPPPDAIKEIVSTLLKTSDVTSCLNTISALKVSRGLALADIITALSEELVKLEVGPEVMITWLDGLANIEHRVAGGGSELIQTGAVVGVVRNGVELMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0C4</accession>
    <name>S0E0C4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428254.1">
        <property type="nucleotide sequence ID" value="XM_023574993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0C4"/>
    <dbReference type="STRING" id="1279085.S0E0C4"/>
    <dbReference type="GeneID" id="35396658"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03176"/>
    <dbReference type="HOGENOM" id="CLU_017779_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="558" mass="61254" checksum="59D0B8C6EFE9A3E8" modified="2013-09-18" version="1">MSCRPQLLRALRGSASSSGGRRTVSLRTNILERSLALSKTPTRCIATTAPRLISQTRVQQSKLTSETYPQLERDARFAQVTPEHVARFREILGNNPSAIIDGITGGGAGVDAADFETYNEDWMHKYKGQSKLVLRPGTTDEVSGILKYCNEQHLAVVPQGGNTGLVGGSIPVFDEIVISMARMNEIRSFDEVSGSLVIDAGCVLETVDSYLAQKGYIFPLDLGAKGSCHVGGNVATNAGGLRLLRYGSLHGTVLGVEAVLPNGTVINDLCTLRKNNTGYDVKQLFIGAEGTLGIITKIAIQCPQRSPAVNVAVFGIESYDKAQLAFREAKKQLSEILSAFELMDGRSQRIVSEVKGQEHPLEGEYPFYCLIETSGSNGEHDYAKLETFLEDVMTREVIADGVVAQDETQLRNLWGWREGITECLGHWGGTYKYDISIPLDEMYTIVEDTKARLVDLGLLGDTSDHPVVDVLGYGHMGDSNLHLNIPVRRYDPAVEKALEPWVYEWIQKRSGSISAEHGLGIAKKKFIGYSRDDTTIGLMKQIKNLFDPNGIMNPYKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0L4</accession>
    <name>S0E0L4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">OMP decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Uridine 5'-monophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_13391</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429278.1">
        <property type="nucleotide sequence ID" value="XM_023576071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0L4"/>
    <dbReference type="STRING" id="1279085.S0E0L4"/>
    <dbReference type="GeneID" id="35406845"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13391"/>
    <dbReference type="HOGENOM" id="CLU_030821_1_1_1"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="13">
        <location>
            <begin position="36"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT67197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="366" mass="40222" checksum="E1AD72A289872270" modified="2013-09-18" version="1">MSPHPTLKATFASRAETATHPLSRHLYKLMDLKASNLCLSADVATARELLYFADKIGPSIVVLKTHYDMVAGWDFDPRTGTGAKLASLARKHGFLIFEDRKFGDIGNTVELQYTSGTARIIEWAHITNVNMVPGKASVASLAHAANRWLERYHYEVKTSISIGTPTASQLDEDSERSDNENQKDTPEPARADSGRKGSIVSTTTVTQQYESADSPRLVKTIPEGDETVFPGIDEAPIERGLLILAQMSSQGNFMNKEYTQACVEAAREHKSFVMGFVSQECLNTEPEDDFIHMTPGCQLPPEGADENEAIKGDGKGQQYNTPQKIIGIAGADIAIVGRGIIKASDPEEEAERYRSAAWKAYTERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0L7</accession>
    <name>S0E0L7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_07113</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430416.1">
        <property type="nucleotide sequence ID" value="XM_023577329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0L7"/>
    <dbReference type="GeneID" id="35400590"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07113"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT68336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="492" mass="53947" checksum="D02EEB2C68F11E78" modified="2013-09-18" version="1">MELQGQSLILTVSVLTSLGFMLIGYDNGLMGGLVNTTAFKDTFDSPDSDMIGVIVAIYEIGCFFGAVFSSIWGEKLGRRRSVFVGCVFLTIGAVLQAASYTRAMMIVGRIVAGVGMGTVNSTVPVMQAEFSPKSSRGIFVCAQLSTLNFGIFLVYWIDYALSSHTGSYAWRVPVILQCVPILAIMGLLFVIPETPRWLAAHDRPEECLQVLARIQGTSTDDPQVQVLHSVITQTVAYETSIDAGSWKDLLKEDSIKSRKRLILSIFLQSAQQLGGINAIIYYSSTLFEKSVGFSAHMSALMSGFLQTWFFVASFIPWVLIDRLGRRPLLLSMISVMAATMAVQAGLIYQVENNTSTAHAAGIAAAAMLFVFQGAFTIGFQATVWVYPSEILPLRLRQRGSSISTAANWIFNYMIVQITPISIDNIGWRTYIIFAVLNSLWVPIIFLFFPETKGLELEDVDHLFGGEDIISQVDEKTNAAVVMMETVGNKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E226</accession>
    <name>S0E226_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430830.1">
        <property type="nucleotide sequence ID" value="XM_023577830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E226"/>
    <dbReference type="STRING" id="1279085.S0E226"/>
    <dbReference type="GeneID" id="35401040"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07563"/>
    <dbReference type="HOGENOM" id="CLU_080764_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="233" mass="24622" checksum="6B0497CC77E2DE22" modified="2013-09-18" version="1">MGSTFRNVARHMAVPVRAISSLSSNPKIKVVKDPKSPFTNYLSYLEKEPPDERLAIGTTSELPPTPQSFTENKDFVKILNEVITEYGHQDEDLINQARAFASPGGFNLGSGGAFFSQKRPNRGGSRKQGAGGGAGGDGAGGASAQGGAGGGGRGGYVHLSDRRNPPDFGRIAWPEDILGSVEVDGNGTIIGKVQPSGTYRILTNEGILGLSPFLQAKLVERLKREEAKQNSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2M2</accession>
    <name>S0E2M2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431111.1">
        <property type="nucleotide sequence ID" value="XM_023578277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2M2"/>
    <dbReference type="GeneID" id="35401442"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07965"/>
    <dbReference type="HOGENOM" id="CLU_842106_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="330" mass="36283" checksum="9D6CC65A3797326A" modified="2013-09-18" version="1">MSELPDKSNSPIPPSVFDSDVDDTNSSPVLLPLTVSIDDDGAGQLSAPQTNTTAELSEPRQIISSGDPSKFLQAELGRPVFAGTYFNEPAYLVQLRLHLSLSSGNRSWLSRIQTVDIHVHVEDAPRDDAQNASENSDSSDSDFEEEEFPHPAIVKAFPSPGGWEGTPQSAEVSLTHGIGMQLGYNPASVSYNIGESRTWTKTGAVKVKVAHKGPGQNKLHVRVEESSVDKAGVPDYLLVPFIIRHRSRRFRMRVGIHARFGFWRGKLAEVVPILGRADEPLFFDPLVMRRAMEKGRRGVNGEKVVEWRGALDEVALQEYSSLIDKNATQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2P6</accession>
    <name>S0E2P6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431045.1">
        <property type="nucleotide sequence ID" value="XM_023578086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2P6"/>
    <dbReference type="GeneID" id="35401271"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07794"/>
    <dbReference type="HOGENOM" id="CLU_160126_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="126" mass="13345" checksum="677C447A3EC4F2E0" modified="2013-09-18" version="1">MGNSSSSSSNPSEEAKDKKTLYERFQAGKKSVPLSDEDMLKYTGKTRDELSAWADTQPGVGKNQLAGSVTAGPISGLGGVAMADGLGGWGPSAHPNDKNRGMKFPPTRENEAKDTTEVTEVVEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2S0</accession>
    <name>S0E2S0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430027.1">
        <property type="nucleotide sequence ID" value="XM_023576664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2S0"/>
    <dbReference type="STRING" id="1279085.S0E2S0"/>
    <dbReference type="GeneID" id="35408081"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14701"/>
    <dbReference type="HOGENOM" id="CLU_047422_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43845">
        <property type="entry name" value="BLR5969 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43845:SF1">
        <property type="entry name" value="BLR5969 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="51278" checksum="6ADF1A7ADBD01151" modified="2013-09-18" version="1">MSPSPAYSLADVLAIARIHPFYCSTQYPPDDKTIQDAREKAASKYERPDLKSWPLLRRSDLYTVIERLINDTDARNTYRHNVYTSVTGGGGGVSKPLFFATDVLKNRRHRALFGEFLKKTGIIECGDWVLSTHHGGSLYRSLDLTLEIMENAGASVLAAGHQCPPATVVQILQDFNVNVLAGDSSQIISIVHQISTIPDIKNKIKITKVIYTSEGLSLMQRIQIYKVLAPVAIYSILGSAEAGPYGASSPFLVDFDPQSNHNDFIIDTRMTIIEVLPLSCAESESDEIPEPLPDGETGVIAQTVLTRLRHPVIRYITGDIGSLHSLPQKSVGRLAKHDAPHCRILRLQGRDHRFSFMWDGCDFQFDKLNTILSNPQSGVLLWQVILDKMQPSQEISLEIRLLGGQSSGDTAHLQTLLARLKACLDVSISNEHRFKVTFVNDALGFELSGTGRKVIRFVDHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2X0</accession>
    <name>S0E2X0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to pisatin demethylase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_14353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431236.1">
        <property type="nucleotide sequence ID" value="XM_023578424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2X0"/>
    <dbReference type="STRING" id="1279085.S0E2X0"/>
    <dbReference type="GeneID" id="35407805"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14353"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT69156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="527" mass="60014" checksum="2B79343B898D56BA" modified="2013-09-18" version="1">MYPTSLAIGTGLLSGTLAHVLIFRKGEWDLYTIKILQGILIVFGLLALSFKRLGTTEAGSPYSFLESIIASIYMVSFMLTGTFSSIFLYRISFFHRLYKIPGPFMARVSNLCLTKRPSALSILDAKVFHAIHSNNSPCSKGPWYNIEQPAISLHMSRDKNDHSRRRRAWDRAFSSKALRDYEPRVVKYTSQLLDRMEATQDMPVDIAKWFKFYSFDTMGDLAFGQSFNMLTGGVKHPFMALVESHMVMAGTFSQLIWLFPLLRALPFLGREDAIFQKWLENQVRHQEQNKPDLPNIFSWLLEDYKTQLYPKEQDWLNLQADMQLIAVAGSDTTSVTLTCLFYLLATNRDVCMQLQEEIDNLFSSSSHLNHSSFAKLTYLQACIDETLRLFPPVPSGLQRMTPPEGLRVGDIFIPGDTIVTVPSYTLYRDERYFTAPDDFVPERWTTRPEMVKNDSVFAPFSVGRYACVGKQLGLMEVGYAACMILHRFDICLSGEGTTSKSAFLKGLRDHFTLDAPRLNVVLTARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2Y8</accession>
    <name>S0E2Y8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative trichothecene biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431309.1">
        <property type="nucleotide sequence ID" value="XM_023578514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2Y8"/>
    <dbReference type="STRING" id="1279085.S0E2Y8"/>
    <dbReference type="GeneID" id="35407724"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14272"/>
    <dbReference type="HOGENOM" id="CLU_052674_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd12811">
        <property type="entry name" value="MALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054550">
        <property type="entry name" value="Mala_s_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22701">
        <property type="entry name" value="Mala_s_1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495466" evidence="1">
        <location>
            <begin position="18"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="347" mass="37308" checksum="5A7D44CC0D2303E1" modified="2013-09-18" version="1">MQSKITLLGLAVHASLAFSIPRPYTCPSISGNKTIDAYQLYPENVDFDTRRCLVYSSVLYNATAVAWDPYRGKIVHTFEAPGLSGDPLLHSSGVRVDTLDRLSVVIDAGAAFDTGGQNIQGDNLLVKFDLVDNSLLWRANLTKATNGVYGGFQDSESDDEGNTFVLGTFPSSLIKVSADGKSVVPWYLVEPANHTIHGFSGISRKGDTLFVTDNTDGQLYTFDIKAAKGKPVRVPTSKNGKALGQNLDGLHLPSLYAGTVLLVSDNTNGTVVLRSSNGKWKSTENLGTISNPYLSQGGFTVASVQISDSIYAVTEFFGDAINGTLPGNRTSFPLRDITEEVETLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E357</accession>
    <name>S0E357_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431170.1">
        <property type="nucleotide sequence ID" value="XM_023578346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E357"/>
    <dbReference type="GeneID" id="35401503"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08026"/>
    <dbReference type="HOGENOM" id="CLU_1378174_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485556" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="30"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="114"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="198" mass="21604" checksum="C3E18A624FF6F6B5" modified="2013-09-18" version="1">MRFSTVVATALAAFSNASPCLAGAPEPVICGGNGYVGATNTPWYKKSQAEGTIEGCFNSCTGGCKAISFDTQYKTCYFYTAEVSKMRLYQVTNSPMTFHYFDRACVADAVGKTCGATGYVGATNTPWYKKSQAEGNMKNCLDACRGGCKAVSFDVKYKTCYFYTAEVSSMQLYTVSSPMSFYYFDRACGYEPTETVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E364</accession>
    <name>S0E364_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429229.1">
        <property type="nucleotide sequence ID" value="XM_023576011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E364"/>
    <dbReference type="STRING" id="1279085.S0E364"/>
    <dbReference type="GeneID" id="35406790"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13336"/>
    <dbReference type="HOGENOM" id="CLU_030520_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="347" mass="36861" checksum="4B0858AAEC0434E6" modified="2013-09-18" version="1">MLEPQAMRGPIDQTVGYGHSRTRTTSSTAFPMQFQTSHLAQPGPNLSQNRRSPSVNTFSTASSIPPPAAYRSSSQSELRRSTSSRSGGASSQPSSYVALLRKQKGTVWCDRSQYEDPRLLAQQRAAKMRATLEVVGGSRSASGGAGARTSTGLSTTNKVAAKIPKIRHHGKNPVVGYAPGENHVGVGGVPMRLSATEVEAESSEDENAGNRPHHRRTGSSGRSSTTSSRRNLAYRTSGGMGSQHSRRWSPGDTPERTGSLVEATPEDIVDDAASGKARSMASGSSGERADNVGELSNAPRLASNSLMHSALTREKSVKSADELRRRGSVDERTSTLTSGRLFIANPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3E9</accession>
    <name>S0E3E9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431406.1">
        <property type="nucleotide sequence ID" value="XM_023576930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3E9"/>
    <dbReference type="STRING" id="1279085.S0E3E9"/>
    <dbReference type="GeneID" id="35400231"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06754"/>
    <dbReference type="HOGENOM" id="CLU_387343_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="333"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="744" mass="83890" checksum="ED36EECC61C64CC4" modified="2013-09-18" version="1">MSDYDPFDRNMRVCVQRNGEIDDVRYCNLMLPRSGPESPGPHSDIKGLMSWPRICGVLTDEEIAHTMQTDSSWTSKPRGCRLRITFTDEESDDDSDDPTNVEENKGSWESRKIPGKNRKRADLTSVDPIPCRVTQVVLEENTNRTLVQLPPAWNCDSFIILAKVFSIIAIALERVEFLGAHSEMGEALVKARSEVQDELLNSLEAEINDTNKLQIAAPVLPFLPLDRLCGGSQPLTLDRLQGLVSRVVPYYAVAPRSEVHRGSCGCLLPGGLAEADKGARISEVKVTPRRFYDALRSSEAHLKDRIVTRPADEPVESYIALSYPWKSYDSGDLERIIAKFHEVLKHRYYWVDRLCIDQDSYEDKETEVPKMKDYYSNAEHTLILPGMPFPLEMAQLEAEGPKVRIYSPELVQQVKQIWESCEWRKRCWTLQEAIMSKQCTFWTGQESAPLIDSSQLVGILCSSPFGNSYINTLPHLAMEIGHTDKTTLVAMSATIADPTEESIYQRAIIRCSIHGTILDANACKRPLAVLLDKIRGREATLELDEYYSLFSMASDKLPAVDYRIDPTQLVERIIGTGALGANILLTSTRQDPVANRSWLPSMCAQREYSMIGAGINAAHPHISEGAMVVAAFPVRMKIADDDNSEYFAAGTELYTVYSYPTETPFDVDMEFTIRRRLKKASHYLFIQPVKWDRSVFTSGLILLATEEKQPGEHRVIDASIMDNMTQHAFLQNDHFGHGRTTRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3R1</accession>
    <name>S0E3R1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429434.1">
        <property type="nucleotide sequence ID" value="XM_023576259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3R1"/>
    <dbReference type="GeneID" id="35407014"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13560"/>
    <dbReference type="HOGENOM" id="CLU_903286_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="308" mass="35418" checksum="9F3857BE7D1BEB34" modified="2013-09-18" version="1">MSSSFPITDFPPRDPSLEIRPVPHKRSFKIRSFGPGADPAIQKTARDLSDVDLDIRPSDYSHEPEFDSQVFERERPFNRWVRDNEDWFGYRKRSDDVRKLLSAVEAHQNKTRGPLGQAATDPTWGYFVFVTSYSSLARKNINQAMENLVQATLRSLRLMSPSLYSEEATKRFKLEVIEDKEALENASEDRVREEFRAHFRSLGVLEDDLMFRGIGTSRFSACILLDEKAISRLANFSFGLDIELDEPRFANVLVRMIDPKWDYPAEPYPGVVDEDDRPYRGGDDCPATALAELYRIIDGNLMGEYPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E583</accession>
    <name>S0E583_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432005.1">
        <property type="nucleotide sequence ID" value="XM_023579108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E583"/>
    <dbReference type="GeneID" id="35399328"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05850"/>
    <dbReference type="HOGENOM" id="CLU_597225_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="458" mass="50741" checksum="772B72F94A500E6A" modified="2013-09-18" version="1">MPPPHPPLLSTTHEHDHIVDASILSIIKPPLPSRRPRTAQSPSNAEVLVPPLIAGALVAAFATALADGLNNELLTHYYLPEQKFRVNIDRIVDRLLSEFTLMLWDELWAFYCDSNPDSTEQIKKLFDGPVCQLILILNGPEAPRCLLDKLGPGISRRPATWSESARGIELPVALQLLCSYWDREYPARSPRGTPNEIAASLHTYITTGRSARHLISRIREVLISPHYVQMHLMESALWHILMKPPYRPPGDGFHAVQFKFECQLFGPLQGIGDPQLVKMGSLPAITGTANDCVYTTVSDYTVKQWPKCGELLLGCIENAVKEASASSCEGHSFTGMSIWDGTENPFLCPGLRLLHVEVEDGSIRLTVSAWTHTMVEIIQQMAWTCAALSSSPFQDSLSESAIEVSDWQYMDDSIFVECNLAHRPVPAGDGSAWLKQMEGAAIANGFPINHVREDSQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5U6</accession>
    <name>S0E5U6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to ferric reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_05981</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432124.1">
        <property type="nucleotide sequence ID" value="XM_023579255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5U6"/>
    <dbReference type="STRING" id="1279085.S0E5U6"/>
    <dbReference type="GeneID" id="35399459"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05981"/>
    <dbReference type="HOGENOM" id="CLU_010365_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="322"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT70045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="618" mass="69626" checksum="970A743FE463DE0D" modified="2013-09-18" version="1">MDFTRRRIADISSYIPTSTLKSRGVAAPADAEATPNYHSNLDGVNQPMNLLFKDALWWTLGIMALVVLSIRIIEILWMRLRQVSAMNVSGPKQAYWKISQWSWMPNVKKNLTYAPLWNKRHNREFKLSSAISMGTLPSRLHFIILFIYLGSNFAYMFVLNWHNENKLAFCAELRGRSGTLALVNMVPLIIFAGRNNLLIGLLKISFDTYNLLHRWMGRIVVLESIIHTIAWLIVAVDDLGWDGVGHKLSHGLFEGSGAVGTVAMTFLLLLSVSPLRHAFYETFLNVHIVLAFVAFVATWIHCASSALKGGLPQLPWIMAIMAIWFADRLARMLRIVFVNWSSKGWTDAVCEAMPGNVTRVTLHLPRYVDIEPGTHAYLRFWGLCAWESHPFSICWVNHVRDNSLPIAEKDTLHAVDKSTMTTTVSFLIGAQTGFTKKLFDRASRCPRGLRIKAAMEGPYAGHNSLDSYGHAVLFAGSTGITHQISYIRHLLEGYNQGTTAARRITLVWIIREYESLEWVRPYMDTILRIPNRKDILRIQIFVTRPQNPRDIVSASATVRMFPGRPNVPLILAREVQEQMGAMCVTVCGPGALADDVRGAARAVQGSTVVDFVEESFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5Z2</accession>
    <name>S0E5Z2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_06280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432398.1">
        <property type="nucleotide sequence ID" value="XM_023579588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5Z2"/>
    <dbReference type="STRING" id="1279085.S0E5Z2"/>
    <dbReference type="GeneID" id="35399757"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06280"/>
    <dbReference type="HOGENOM" id="CLU_054412_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="75"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT70319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="350" mass="37461" checksum="FFA931B21799A214" modified="2013-09-18" version="1">MSLPSTKPAQTSIRSFFSAKTPKYAPPPSQGASIELPPPPPPPAATAPPPTSKAPDSTIASFQIPPLPTSLPQEAAIRLVSNDDINALRRINALLLPISYPDNFYQRAVDPTSGRFSRVITWAHDGSEAKVVGGVVCRVEPILDSNSQGVMPQNLYIQSLCLLSPYRSLGLVNAAVDNIIAGAVSDPNLNVTTVTAHVWTENEEGLKWYEGRGFKRENQPIEGYYLKLRPNSAWLVSRPTGASVRNLLPSSSSAPQQSVPTSATAEIANLDTASGPPRNSTSRPPMPQSGKSYQNQRPETEWNDLPDDMANSRLAPPPRVGSTGSGASSRSSSAARKKRDRSYPAAAFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6F3</accession>
    <name>S0E6F3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_06445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432548.1">
        <property type="nucleotide sequence ID" value="XM_023579770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6F3"/>
    <dbReference type="STRING" id="1279085.S0E6F3"/>
    <dbReference type="GeneID" id="35399922"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06445"/>
    <dbReference type="HOGENOM" id="CLU_070115_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT70469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="360" mass="40046" checksum="77CB0DA3FEF4243B" modified="2013-09-18" version="1">MISSRAVMGFEWSFMALAYTSVACRIYVRVVMRKARLFSADYWLIAGLLSCQGLLICDTITYSMDAMDNFTIDNVAIRKVRFATNHLFDTGIYFPKFSIIAFYFNLVPISQPKMRIALYCLAGITASFAVITFFCDWFWCGPDPSVNWAKGEQECTSFTSMTLMRLLWSMNFISEVLNVAYPIPLLATLKMTSTRKKIGLAIVFSLGVITIAVSVGRFITMVYVDNAISIYIWATAEICISVIVVALTAVRPLLRKLINLKSTTLLTSEDQSGVQAIPPNRSRKPGTFNGGTGVYWQGTGKNHQRHAETMSPESIAGSETELNNINGITLSQNVTVSRETITNSVNGQPEYSTVHRIESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7A9</accession>
    <name>S0E7A9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432825.1">
        <property type="nucleotide sequence ID" value="XM_023579148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7A9"/>
    <dbReference type="STRING" id="1279085.S0E7A9"/>
    <dbReference type="GeneID" id="35399364"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05886"/>
    <dbReference type="HOGENOM" id="CLU_031468_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000609">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF26">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="211"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="348" mass="38200" checksum="4DAAF317DC8FFD71" modified="2013-09-18" version="1">MADNSRVDIIFIGAGAVGCFYASRLHHPSQNIHVSLVARSNYAAIQKDGVKLLTRSFGDYTFNPDAAFPSVDAAAGTSSGAKRDWHYIFVTTKALPDISDDSSIIEPLVGPKSCIVLIQNGVGVEEPFRKRFPSNPIVSAVTVVSAEQTSPGTIRQNRWTRISIGPYTDGLASKNSELGRRGTESTDALRRWWTELGGIKDVDPHDEVGLQTVRWHKLCINSAMNPSAVLSGGRGNADMVADDELQRHLLGVMHEIRDAVPRILGRPFPDSMAKPEKIVESTARNKGARPSMLLDWEAGKPLELEVILGNPVRIAREKGVEMPRLQSLYALLRSAQAMRRREQTKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7Z5</accession>
    <name>S0E7Z5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable farnesyltranstransferase (Al-3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430643.1">
        <property type="nucleotide sequence ID" value="XM_023577594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7Z5"/>
    <dbReference type="STRING" id="1279085.S0E7Z5"/>
    <dbReference type="GeneID" id="35400829"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07352"/>
    <dbReference type="HOGENOM" id="CLU_014015_6_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT68563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="418" mass="46544" checksum="09EE3BE7C61CAEF6" modified="2013-09-18" version="1">MIPTADPILSFNPEALPPSALHMLSLSPKAMEKMSGISNPLVSPNAIPPRTSSTGIPTSLNATPTKPVLRPVPEGDWLSQKQLSPRAQMSNAGYGVMQAPNPPPDPERYAHEDLEFTAKRSWTDEKENVVRGPYDYVISHPGKDFRAQLIGAFNVWLDVPTSSLEVITRVVGMLHESSLLIDDVQDSSELRRGFPVAHNIFGVAQTINSANYIYFVALQELHKLNNPELITIFSDELVNLHRGQGMDLFWRDTLTCPTEEDYLEMVGNKTGGLFRLGIKLMAAEANGPSPTDCVPLVNLIGLIFQIRDDYMNLSSKEYSHNKGMCEDLTEGKFSFPVIHSIRTNPTNLQLINILKQKTSDTQIKRYAVAYMESTGSFEYTRKVLSVLIERARKMAEELDQGRGSTKGIQKILDKMAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E871</accession>
    <name>S0E871_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_09131</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432929.1">
        <property type="nucleotide sequence ID" value="XM_023580091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E871"/>
    <dbReference type="STRING" id="1279085.S0E871"/>
    <dbReference type="GeneID" id="35402605"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09131"/>
    <dbReference type="HOGENOM" id="CLU_009665_12_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="302"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT70850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="792" mass="86428" checksum="AD4A95B1779130AC" modified="2013-09-18" version="1">MSIQIIKNQTSRRVVNMGFKVIIVGGSVAGLSVANMLERFDIDYVLLEAYPQIAPQVGASIGILPNGFRILDQLGCFEPILDIAGDCRYTIGGMYGSDGLPLAPSSTTSLSIHFEKRVGYPSIFIDRQMLLQVLYKNLKHKDRVLTKKRVTRVELVEGGVQAYTQDGSVYEGDIVVGADGIHSAVRDEMWRLGKEQSPGYFPEDENSRVPVSTRCIFGISKRPSALGYRSQQMVVGDGHAYLIIAAPGDRTYWFLFDGLPETKRGKDISKYTKADEEGLVKEHHGDHITQDVTFGELYDRKIMSTLVPLEEYVFDRWHYKRIVTIGDSAHKIDPASGQGGNGAMESAALLVNALVRQLKLSPQGLSDSRVDSALSEVHALRYERAKRLVEQAHSLQMMISQRFPFARFIFKHLIPIFGPDAFIDIVTPICCEATRIQGIPVPRRPHFVPFEDELPVKPIKSGLARRVPWVLAIGTLGLSLFATLKTKDFGARTGALYSVLQQWGSGGLLGKVVGQSSVTGLASLTPVISSWLIEGSRRGNSLNPLSWTTVYSLIYSFIGPSSVLPFFCLSSVLFSTKSTVHRPVDPQIAKSIVPGVFLGYVAPTVAALLPIRDAKLRHYVGTVWQAYPFLCAVFTRGLAAIRAKTANSGQQEADTKVEERPINYAPPSELQMYTNEDVAPLKFSHGCALALCLAASVIAKTLSTDWTLSALSQVAPFGPNAGVISAASGLAYSLYAVWELRSLGFVRTKQAVLGGMACVGALELAGPGAMIVGIDYWREHVTASLSPDTGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E973</accession>
    <name>S0E973_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to mei2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_07942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431088.1">
        <property type="nucleotide sequence ID" value="XM_023578252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E973"/>
    <dbReference type="STRING" id="1279085.S0E973"/>
    <dbReference type="GeneID" id="35401419"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07942"/>
    <dbReference type="HOGENOM" id="CLU_019467_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12532">
        <property type="entry name" value="RRM3_MEI2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034862">
        <property type="entry name" value="Fungal_Mei2-like_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="411"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT69008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="607" mass="66910" checksum="3CC24C51520D1CEF" modified="2013-09-18" version="1">MSSRADHRVYANMSSPAEGAADSIQGTPNTQITVFSPAESSQGTSVQGNNYLGQSQAPEDPFVDSSVSHGSTLSATASSFEPLGQRFRGKNALVFYPEGSPTVAGALSHDMDISHRIEVCDTPAPSIVELGNYITELTQKGVRFHGGRNLETDGGHVYVVFEDLRDAAWAFYAIRKAPKGWFTAYVKIRPERLDLGLVRFSELRQLSIEVNVLNFSIIDPAHVDEIAQRALNVYGQLFALLRHLSYPNGAFRGVAQFCKAADAFVAFKAFGNGITTGGVVITLSKPEDVGNAASVDNQLAGAFGNMAIQQGTRGVDRGRHQSFFALNAPQGNPFAAAGAASIPFPPTLQQHPFTGQQFGPPGASNTLALTNPNGFGRFDPRRGAGRYGRGSRGLNNIVDLNELIAGRDVRTTIMLRNIPNKVDQPLLKKIVDVSSFGRYDFMYLRIDFANDCNVGYAFINFVKAEYIIDFFQARANKRWNCFRSDKVAEISYATIQGKDCLVQKFRNSSVMLEAEHYRPKLFYTIHSDDPNLVGREEPFPGPDNQSKMKRSVENAEHVGLFTPTAGQYFRDEQRRRHSQYDRGTRLAELEEISYGSGVIPYHGRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9M3</accession>
    <name>S0E9M3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08361</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433633.1">
        <property type="nucleotide sequence ID" value="XM_023580947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9M3"/>
    <dbReference type="STRING" id="1279085.S0E9M3"/>
    <dbReference type="GeneID" id="35401837"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08361"/>
    <dbReference type="HOGENOM" id="CLU_003143_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1005"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="895"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="917"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="933"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1195" mass="134410" checksum="8B20CD6189844554" modified="2013-09-18" version="1">MGLKQFNLDLRVTIEALDSFPNVSNLRKGDSDGEIAFTYTPAAEHEAQLPPIDVQALSKDADSYPNHPGFMIFTSSETPKDLEKWLEETSSLTDGITIADAIKLICSMLATKLSTSNQSISQAPPYYGEESDVDLLSDDDDSFYEAEFDEIDIDPLLPGASASEHATEADDPESMIRLKRHLREAKQEGFCISIPPEEIRQSSFGIFSLSVRVCKLGIPEEALEAWGIEPTEYIVMLCKLPSTYPHVLDFQRLPPDQTRMNFKLGKCSSPRPNYKSMRHMFAGAEEPVMPTDKDEESTDSFIPLYMSLSLDALLNRFFPTLLRLRRSEGISWDEARELEYNLSLGHHSRDMVDHAQDVIVCQDRESSDESFEPEFLRHDYLSSNADELNIVLIAMQFGLQRLIKCTKYCLVCHRRAKGGFEAVKPFVCETELCLYQYLSLGFGQSIEHEIINNPYVVDFLVSFFYAAVIRSRLREFPRGLGLKCPSSAFTASASTPVSADAYFNTGLLRFESKDLHACRTIKTGHWLMLFVAGANTLDSQTPVMRTYREKHICYIESCIDTDFWFKVMHTFTSLDNIGQETPDNSVNQATQPTTDGVKVLIYKYGQDIDELEDAVRDQALCFMTSCIPPVQTMRQYLIEVPGRRLSSWKQIEGSALRLLNWIVSSNRSHIVQDSPDPGASAAEEQTQNSSLVRSADYRWMQFRFAQGSPEKEHIFFNELQKIPRSRTGRTYQTLFAWHGSPLSNWHSIIRTGLDFSNTLHGRAYGNGVYLARDFETSRAYSNRDTMKAWPSSALKVTSAISMCEIVNSPSQFVSTNPFFVVNRIDWIQCRYLFVQIQIRQPESSVSLSNEGLFPDRVQGEDYIEQDPAYQLTHGLQQRVNIPLSAIPKFRRRAFGQGQQNGTGSSIDHPIVLDDSDSNGSPNLNDSSSSESPEMSDDIDVLLASDDEGDDLQLVGTRKRRRTSTDSGLGETQRGPDDVTPFQPGHLDIDSLPKLAEPTWASSSPAALRALNGQIKDLQKTQSKTNLATLGWYIDFDKLNNLFHWFVELHSFDRDLPLAKDMASHGCSSIVLELRFGASFPISPPFVRVIRPRFLPFAQGGGGHVTIGGAICSELLTNSGWSPALSLEKVFLEVRLNLCERDPPARLERVHHISLGKMDYSMFEAVDAYRRAAVAHGWQIPSDLQMLQSMSNVSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9R1</accession>
    <name>S0E9R1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433720.1">
        <property type="nucleotide sequence ID" value="XM_023581052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9R1"/>
    <dbReference type="GeneID" id="35401743"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08267"/>
    <dbReference type="HOGENOM" id="CLU_153339_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="139" mass="15217" checksum="D1BB2D1EC8375332" modified="2013-09-18" version="1">MKLIGPRKSTTTTTTTPNTMTSLTISVLFLLGLVTAGVVRTPTETATLTTEATIPAEAATLITETTTPVEVTTPVATPDAFVAKGENLASCNIQCAFWYQKCYYRPWGYTCDDNGLFRRRGWNPDCEKNCWCNCDSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA79</accession>
    <name>S0EA79_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable general amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_08106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433868.1">
        <property type="nucleotide sequence ID" value="XM_023581231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA79"/>
    <dbReference type="STRING" id="1279085.S0EA79"/>
    <dbReference type="GeneID" id="35401583"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08106"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF39">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="48"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT71789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="562" mass="61869" checksum="571F001C738D5A13" modified="2013-09-18" version="1">MDANKTELGISPVESNRPGSLLDTDNKPVVNELVEKYGQTQRGLKPRHVQLMAIGGSIGTALWVGIGGYLSQAGPLSLLLGYTFWGIFFIWPTYLCVAEMMAYLPVRGSIFELASRFVEPAVGFSLGWTYFFGTCMLVCVEYSAVAAVAEYWDSTTNPAVWIAVSMAICIFLNVVAVKWYGEAEFILAITKVFLLILLVLITIITMAGGNPKSDAYGFRNWKDGAMHEYYAKGPTGRFLGWWSVVIYAAFTIAGPDMIALAAGEIQNPRRTIPRVARMIFYRLVGFYIVGALAVGIICSSKDKRLISAIADGSSGAAASPWVIGIQNLGIGFLPHFINALILVSGLSCGNAYLFAASRTLYGLARDHQAPKILMKCTKNGVPIYSTAAVSLISCVTFLVASNSAIEVFFWFVDLTTTAFIASYSFMLLAYIGFYRARKAQGLTDESLSYVAPYTPYTPIMALALGCTAIFFVGFDVFSPFSLRGFITSYFAVAFTAVMYLVGKIKYWREGKGIVNPKDADLITGKAEIDEECRHWEEGGIEEVERARLAEMTWARRAWERMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAE6</accession>
    <name>S0EAE6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Probable endoplasmic reticulum insertion protein SEC61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_08947</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433933.1">
        <property type="nucleotide sequence ID" value="XM_023580296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAE6"/>
    <dbReference type="STRING" id="1279085.S0EAE6"/>
    <dbReference type="GeneID" id="35402421"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08947"/>
    <dbReference type="HOGENOM" id="CLU_031763_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070843">
        <property type="term" value="P:misfolded protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT71854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="476" mass="52193" checksum="B2608998BD575E77" modified="2013-09-18" version="1">MSSLRFLDLVKPFVPFLPEVQQPETKIPFNQKLMWTALTLLIFLVMSQMPLYGIVSSDNSDPLYWLRMVIASNRGTLMELGITPIISSGMVFQLLAGTHMIDVNLDLKSDRELYQTAQKLLAFILSAGTATVYVFSGLYGPPSDLGAGIVFLLILQLVVAGMIVILLDELLQKGYGLGSGISLFIATNICESIMWKAFSPTTINTGRGPEFEGAVIALFHLLMTWPNKQRALQEAFYRQNLPNIMNLLATIAVFAAVIYLQGFRVEIPVKSSRQRGARGSYPVRLFYTSNMPIMLQSALSSNVFLISQMLYSRFSENLLVRLFGVWEAKDGSSQLHATSGLVYYMSPPQNMKEALLDPIHMSAYIVYMLGACALFSKTWIEVSGSSPRDVAKQLKDQGLVMAGHRDQSMYKELKRIIPTAAAFGGACIGALSVTSDLLGALGSGTGTLLAVTIIYGYFEIAAKEGDMAGMKGMIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAK1</accession>
    <name>S0EAK1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432866.1">
        <property type="nucleotide sequence ID" value="XM_023579908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAK1"/>
    <dbReference type="GeneID" id="35400045"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06568"/>
    <dbReference type="HOGENOM" id="CLU_2704848_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495721" evidence="1">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="71" mass="7155" checksum="82020C810210924A" modified="2013-09-18" version="1">MRPSGILIMATAFISVSAQNCKQRSAICSPFSLCSSMPAAGQVCGSQGTASNCNSVADRGSDSGTVTCQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAU6</accession>
    <name>S0EAU6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_08115</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433859.1">
        <property type="nucleotide sequence ID" value="XM_023581220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAU6"/>
    <dbReference type="STRING" id="1279085.S0EAU6"/>
    <dbReference type="GeneID" id="35401592"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08115"/>
    <dbReference type="HOGENOM" id="CLU_015739_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000018">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015328">
        <property type="entry name" value="DUF1965"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09248">
        <property type="entry name" value="DUF1965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495729" description="Amine oxidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="12">
        <location>
            <begin position="74"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1965" evidence="13">
        <location>
            <begin position="244"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="323"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT71780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="791" mass="88288" checksum="9817E904FB0409CA" modified="2013-09-18" version="1">MRPTISLILCLFAIPNGISAYPGPAGPATRPHSLKRLSEYKSSTSGCSSGQEVVIKAPVKNIFQSLTDEEYAHVTAYLHEQKDLNLTAVVNSTSWDNVIVSLDLLQPNKTGALTYLEGHGPAPVRYARAILQFNSKLQPYIQEYMVGPLPIQKGLTHHEELNYIFTSGRGRINVYNADGEAIAAFNLKIGTEIKDITKELLNGTATGAETDNLLIAGSDPLIHRNDRVYQWNEFYSAHTGEFYSETVLPTSLQFKVDLTGRDPSKWKVVGWYYDGNFWPTTAAFRKGIKTLKRRPGPVVDGSWTSTDQQGDSFPRDHLYPPISVQPDGPRFGVDREQNYVEWMDFSFFLSNHKETGLQLHDVRFKGERLIYEFGLQEALAHYASQDPLHASSAYLDSSYGIGTSQWNLVDGFDCPSHATYLNTTFYISETTHVHPNSLCLFEYDTGYPIQRHLTTDYVSATKNIVFTVRSVSTVGNYDYLFEYSFYYDGSITVTVRASGYIQGAFWSGDGDYGYHIHDNLSGSMHDHVINFKLDLDVKGTKNSLMKTEFVPHTQVYPWSDGQSINTMKVNRTYIASEDDSKINWAPNGAASYSVVNRDKLNDFGEAPGYSITPNSGSTAYLTVQSSSALGQAANWANHNLYALQRHDTEPKSAYAYNSHDLNRPAVDFNKFFNGESLDQEDIVLYFNLGMHHLPNTADLPNTVTTKAVSSMLISPQNYFAGDVSRRTVHQVRMSFDKNSNVTGVKRFGVKQPTCALDMNTVAPDLSTFVGEIEIPKFPWNPSGSLQTNPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBE2</accession>
    <name>S0EBE2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to serine/threonine-specific protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_05668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431838.1">
        <property type="nucleotide sequence ID" value="XM_023578905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBE2"/>
    <dbReference type="STRING" id="1279085.S0EBE2"/>
    <dbReference type="GeneID" id="35399147"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05668"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_33_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="375"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT69758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="736" mass="81170" checksum="A468151CD0DD3E73" modified="2013-09-18" version="1">MAALSAPRAMVAPHQHQPQGPSTLVTDKSTSSSTFRPNQFQSLSSPREYSTDLTESIVLEEGGESGSESAAEPVTPVSGRQSQDFTLQSQDLQDLQNLQSYQTASATSSGVVPIAIPNSANPNKGTYISQSVNNSRPPTTYEPSTPRATEPEPGSSLTRQSTRGSISTSSFKRTMSSFFRRSNSHVKNDYIPSESATPSVVSAPTEPQTNGQPRAAARRRFSMNRSSATTRSNSPPLPSDNGLEMAPAHRERASDKSLPSQGDFKKNRASTGLTLRGRAINFVGAHNPSRGTGHKRPEYSRRASSYDGSRPSTPLPPPAEGDETMYPPERSVWPLPPDSGTGAKARRMSLSLPDDFAVDVAELQNEFEYQRKFLGRHGKHLGKGAASKVTLMMRKGYPEELYAVKEFRGKSHRESQQDYENKIKSEFSIAKSLHHPNIVETFRLCTDHGRWNHVMEYCSEGDLFSLVSKGHLKGDDRKKDRMCLFKQLIQGVHYLHANGIAHRDIKLENLLITKDSKLKITDFGVSEVFCGTHPGLREAGGQCGRNMSGEIRLCSPGICGSEPYIAPEVLAKKESYDPRSLDVWSSAIVMIYLTFGGAIWSRAVPGELHYDKLVKGWETWYGKHPEPDATISDTDYPKCYALDVGMSPPALRRLVLQMLNPDPQKRISIEDVIHNRWLKNVECCQLESYDDPALLIDATKKDNTANGNKKIFCHNHLPPKGTGSHSLGKMPGQPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBL9</accession>
    <name>S0EBL9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_05734</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431898.1">
        <property type="nucleotide sequence ID" value="XM_023578979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBL9"/>
    <dbReference type="STRING" id="1279085.S0EBL9"/>
    <dbReference type="GeneID" id="35399213"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05734"/>
    <dbReference type="HOGENOM" id="CLU_064525_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="114"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT69818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="264" mass="28524" checksum="96BADB632E5160B7" modified="2013-09-18" version="1">MAADRQTIIEVNRSLRNIKNELENLLERGVIDDSVYDTINTALPGESSLSGPLKTATGNKNVNTAAPKAATPAPAAHAPPTKAFEDLKVKSHSPAPPAYDQTPPPGPPPRNVKPTVANARALYRYAASDGRDLSFEKDDRIAVYEYMNQDWWMGRNERTGQEGIFPRNYVLVDQETKKPVAPIPQPQYGYPAYSQGPPPQQNPYNSHVPPMAVAEGSGQPQGQEGDGKDNKVNEYGKKFGKKLGNAAIFGAGATIGGNIVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBS3</accession>
    <name>S0EBS3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5 15">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 15">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 15">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_12268</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5 15"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434479.1">
        <property type="nucleotide sequence ID" value="XM_023581853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBS3"/>
    <dbReference type="STRING" id="1279085.S0EBS3"/>
    <dbReference type="GeneID" id="35405724"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12268"/>
    <dbReference type="HOGENOM" id="CLU_013088_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000049">
        <property type="entry name" value="Amino-acid acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011190">
        <property type="entry name" value="GlcNAc_Synth_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007892">
        <property type="entry name" value="NAGS_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="482"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT72401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="660" mass="71932" checksum="E4BD986FD28E9E7A" modified="2013-09-18" version="1">MSWPRVLKQAPRCGHCAPSTDSRLIVSSNSIATPIRSRYRGFASQSGNTISLPCLGKGATRRMSAASTALAKKKAIDRDFIVSVLEVSATKRDAKGYLQKYTGKNPKSLTDAPLFVQGDPQQETEPLDIAPPHVAIMKLRVPQEIDATTLAGVANTLSQLRKLGLLSVVVIDCGIDESRMTFQDQAFRLCEAIDSFGEHGARVVKHAFVCSEPVGQKGKSQTTDIRLDDPAFINHILHHRMMPVIPSVASRDETRPPQPADSNQIVLALTRYFAGVQSNTTNTFAEADAAPSKPIALVERIILLDPLGATPMTGRPGASHRFINLEQEYEPILKELMGPDGSPLADDKDLRASITAHAANLALAKDALAMLPHTSSALITTPGAAANLMKTSFEPNEATGSDSLFGIGGIVTTRRKKNPLLHNLLTDKPVFSSSLPMARAPTNSGREPTVGASGGSTLLKKGMPLRVFPHPRESPWVPPKPGSPRLRLTDKCIDLPRLVHLIEDSFGRKLDVDDYLNRVNENLAGVIIAGEYEGGAILTWEKPEGLDDQTAYEKGRYVPYLDKFAVLRKSQGSGGCADIVFNAMVRGCLPDGVSWRSRKDNPVNKWYFERSLGTSKLSGCNWTMFWTTPNLDSQSPMLRDYESVCRGVEPSWADNKHILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC55</accession>
    <name>S0EC55_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_12339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434542.1">
        <property type="nucleotide sequence ID" value="XM_023581934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC55"/>
    <dbReference type="GeneID" id="35405795"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12339"/>
    <dbReference type="HOGENOM" id="CLU_023630_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000251">
        <property type="entry name" value="Extracelular serine carboxypeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485469" evidence="6">
        <location>
            <begin position="21"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT72464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="539" mass="59601" checksum="9FBAF07FAFF6810C" modified="2013-09-18" version="1">MWFAGCASAALLALTARGSAYSIPALSLSARADSDSGSIKVHNISVPVDHFHNETKYEPHSDKKFPLRYWFDAQHYRAGGPVIILASGETSGEDRIPFLQHGILKMLANATGGVGVILEHRYYGTSFPVPDLKTKNLRFLSTEQALADTAYFAENVKFPGLEKHNLTASNTPYIIYGGSYAGAFAAFARKIYPDVFWGGISSSGVTQAIIDYWEYFEAARLFAPGDCAKVTQKLTQVVDKILTGSDKEEKKQLKIAFGLLGLRDDDFANAISRGIAGLQGNNWDPAQDSSDFGIYCGSVSSDAILYASTRSLAPYVKKWLSAHANKNDVKYLTNRFLNYIGYMRSNVESDKQGGCQGQTVDECYSIREMYGSTSLNPSSSGRQWTYQTCTQWGYWQTGSGVPKNQLPLVSRLIDVEYSTIPCRKQFNITAEPDVESINKLGGWNFSYPRVAFIDGEYDPWRAATPHAIGLAPRKSTASEPFILIPYGVHHWDENGLDPNATEIGLPPPAVAKAQQDIVDFTKAWLEEYDKEKVKRANDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC89</accession>
    <name>S0EC89_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to transport protein USO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433511.1">
        <property type="nucleotide sequence ID" value="XM_023580798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC89"/>
    <dbReference type="STRING" id="1279085.S0EC89"/>
    <dbReference type="GeneID" id="35401971"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08495"/>
    <dbReference type="HOGENOM" id="CLU_006318_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="6">
        <location>
            <begin position="339"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="949"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1015"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="673"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="954"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1076" mass="120209" checksum="6A4304D3E9C66F0D" modified="2013-09-18" version="1">MFSIASAPAKQSVGETIDVLSGRLSSATLLEDRRAAILGLRSFAKDYPASVASGALRGLIGSLSKDGEDVDTVKVVLETLLMLFNPNEDSPEASEEIALWLADEFTQRQENITLLLDFLETNDFYSRLYSLQLLAAILSARTERTEECIFTAPLGIPRLVSVLDDQRDAIRNEAIVLLTYLTPTSIEIQKLVAFENAFERLFAIIEADGALVEGGRTVEDCLILLANLLRSNSSNQALFRESGCMNRLSDLLGRVLKPQTDGSEIASWAAAQRNRNVYAFLAVIRLFVVRGSAGTSLNQTAIWKHGLAYHILQLAFSHEAQIQIKAEALVTCGDVIRQNAPLQEAFAQMMVLAPLAKNGTADGQASQGEKVFVIDGLLDLTLCLQDLQEFDVRFAAAECLQAYFSHHPAVRLHFLGRAIEGHQSGANESSNVLTVLLQPPVESSDPYRQWFAAVITFHLLHENSEAKSEALGLTEGDSEDGEEVVTAIQTLSAHVTSGLRRGDDTRVLVGYLMLLLGWLFEDLDAVNDFLAEGSNVQSLIQAVSQPPTIGGGEIVQGLCTMLLGVAYEFSTKDSPIPRATLLSILTARIDRDVYLDRLSKLRSHPSIRDFEVLPQKLDASSPGRLPDVFFDREFVEFFKDNYSRIARAIDREPGMEISVVTNGVQKGVSRELVDSLRSQVEEKQNTVNEIQEKLAVLQGQLGQEQADHRRSKETAALEMQRVKTVNEGLQKHHSEELRKLQGQLVSKENDQRKQVAQLQSQYSIKENEYQKQIAQLRSQQTAQENDHQKQLELVRKVAEAEAEKIRRRTDAEVADLKANISRLEVVLMKSQKEYNALQLQRKNEIDMQREKYEKVLGHLRQEYEDFKTQSKAKADEKQARFKEELQGLCDRKDAEIDAYRDQSQVDLEQQKLKTKEAEEKCQSFKKQLSGGDAGKKGLEAKLRNMESELSAANKAKDAAEKQLSELKEAAKEEAKKAREATEKKLQESNEARETTQSELDDLLMVFGDLEEKARLVELGETVSDGEDDDGEEDDDDDDDDDDDDDNDNEGEKDGQESENNDDEKEETKQKPKAKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECZ8</accession>
    <name>S0ECZ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to transcriptional activator Mut3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434832.1">
        <property type="nucleotide sequence ID" value="XM_023582277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECZ8"/>
    <dbReference type="STRING" id="1279085.S0ECZ8"/>
    <dbReference type="GeneID" id="35406102"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12646"/>
    <dbReference type="HOGENOM" id="CLU_011099_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="558" mass="62931" checksum="698D3333105AFC83" modified="2013-09-18" version="1">MPPAQMTRKACDVCYRKRIRCDGQKPRCSHCVLYKSDCTFQATSRKAAIRKQPNRTAAALQSQVQSLETSLDEAQQRIKELEERLTQKSSLQNPLQSLQPQLGEYDVSYSGRASLDLGLELPPQHEALSGVNKFLATFNTILPLFHPQRLLSRVNSWYERPHQRDTSTWAAINVVLSLAYRHIPDEEKPPNYSTLHFMNKAQSVLNDIMLGDSSLLDVQTIVGMVVLLQATSDLKPASALIPIALRLAHGLQLHSRSNSDHLSASETLERDRVLWIAYILDRDISMRTKLPPIQSQNDVSIDWPSATPTDGAGMLYTADNSSSFNFFLSRVQLAHIQGEVYEAMLSKSPTASDAYVRFDNVTRIHQMLDDWLARIPSEFSPSAITQSGNANLQRAFGVLYSSHLTCRSVVCKAHAMEAQWIPSLQDFGRKAVEQEAVTAPRLPVGWHKLVHESREYIELFIAINRKDPAFIWMTACTYISAAVCLTANSLFNPWHTKAGTDDQLIDPAFSFLDDIILQAPLPQLKRLRHSWDELLKNSREMSFRNAVQNVDWLEATCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED94</accession>
    <name>S0ED94_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432442.1">
        <property type="nucleotide sequence ID" value="XM_023579641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED94"/>
    <dbReference type="GeneID" id="35399805"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06328"/>
    <dbReference type="HOGENOM" id="CLU_038406_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF19">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="545" mass="61769" checksum="8587E62AE08A9BF0" modified="2013-09-18" version="1">MESSVSSGDASSSRSRAVNDPVLRNTLRYTISAHEYASLHKYILSRSRVLRRATPTPTRVEKALQPPKGGDDYNARTVRHALRVFVMTFLGMKGWDIVAKRMGKEEPSTGGKKKPFYKSPALRLSISLSTILLLYRILFRFFTRLRVHLLDPQVEPFRARNPRTAAMLTSPSAPAIGASFAGLALGIYPAQKMRVTIAIYTIFRALEFAYNFCEADGLIWGRKNGVKRERPWWFGSWMLQPFAFGQLLHAAVFDRDCFPKPFGDLIFKSSSAYLHPRPQDWPSSVKWPQTSEIVDSLAQMARLSWPAYVSPTLFPGKEVLPPSLSAIAPLTSRAHPLITSLSCATLHPGDPSCARTYLTFWLQTFPPFARFFVAVFSALTVIPRFSSLYHNPLATLQRIITKALRMSTFATGALSTAWASICFFQQWLPRHVLATQRVFLGGFFAGLWAFVERRNGRGLFLYSARASVDSLWKVGVKRRWWKSMKGGDIWVFMLALMVTGVVYEKDAQAIRETNWRKGVSWLQGQGWRDWGAEDDEDEENKDKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDF7</accession>
    <name>S0EDF7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434987.1">
        <property type="nucleotide sequence ID" value="XM_023582456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDF7"/>
    <dbReference type="GeneID" id="35406262"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12806"/>
    <dbReference type="HOGENOM" id="CLU_2223504_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012407092" evidence="2">
        <location>
            <begin position="16"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="117" mass="11392" checksum="6C6EF7BD4C4B3C1F" modified="2013-09-18" version="1">MKVSTMLVFPALALGAATPKLPVSSIDPACLESITSVADCIKNINPTGAAALTDVATCLAELVAGVQRCIPGVPGGLPSGLPTVLPTGLPTGLPVPLPTPLPGGLPGVGTPEIPGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDJ3</accession>
    <name>S0EDJ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433990.1">
        <property type="nucleotide sequence ID" value="XM_023581091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EDJ3"/>
    <dbReference type="GeneID" id="35401707"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08231"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_23_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031353">
        <property type="entry name" value="NACHT_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17106">
        <property type="entry name" value="NACHT_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT-NTPase sigma" evidence="4">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="131"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="5">
        <location>
            <begin position="407"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="688"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="785"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="818"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1283" mass="144832" checksum="E30D34078DBD280E" modified="2013-09-18" version="1">MASTALVENDPSPEKFRRDVIARKPVKSSTKLATQTTATVEACKVDDSPRNDTSVSTWGNSFNVSGGIQYNNTGNGSQFLGSQFHGDVNFVGGNGESEDQSRERRKAQILKRLATSPYRGRKDRNPSAVQGTCEWFISHHLYHEWLGQDASKILWVSADPGCGKSVLVKHLVDSVIQTTDSREVCYFFFKDDFADQKSLLSGLSSILQQLFMLDSALLSDEILLQFDANAQWLTASFVELWQILIQVADSNPATEIICLIDAVDECNEHERSQLFRALCELCGSKKTLNLKFLITSRPYREIGMGFKPLENLNLPVIHLSGESDSEMRKIVREIDIAIRERVKTIAVQQILTDDEQLILITQLLSVRNRTYLWAHLTLDLIERQLDISEEKIISITSHLPQNVNEAYERILCRTFSKDKATRMLHIIIAADRPLTVGEIVVALELQQHHQSIDDIEIEPEDRFREKIRDICGLVTVSESRIFLLHQTVKEFLISIDHAEPTSLSWKQSVLTQDSNLTLTYVCVWCLQLDHWTKGQHSANSSLSKHTSRNLFVNYAAKHWANHFNRLSVHDQKKLTSLALEICNTQGSCFLAWFPVYWRSRHARLVSGFTTLMVASYFGLEAIVRSILKTQYSQLNRKDETYHRSALSWAAGNGHDGVVERLIRGLSIGPRSLKIILRQGANVNQFDSDNRTPLTYAIWNGHVSVVRRLVEAGAWVDVPDVLGGTPTSNERKFENKNLVVRGNVPSNANRTEGEKLLLSAVKYGHIHVVRVLLEAKKTNLNLKDDEGWTPLMWAINYRHSRIIKLLLEHGAHVDIRDRNGMTSLYFATRYGQFEVEKLILQTGRADVNIPDSTGLTPLHQVARWKQDDTAQLILRTGVADVTARVHGKDPTYSWVIRYNSCSTLKLMFDLYDENVSVQDCTMAILETDNEWLDKDWADKLKVMLEIRKIDVNLADSKGETILHRAVIKRSYQMIKEILATEKAPTNRRDSRGLTPLTLACLTLDSDAVSLFLETDSVDVNIADTKGYTPLHHAVQEHSAPITGALIATGKTRVDMKNKDGRTPLCLACLSGNTTLAKYFLHHSQVNINTQDKYGRTPAHNCVLMGNVNMLRLILHTGKVNLNVVDNLLYTPLLLAAHRSQWEIVVLLLKYEQAINMKDRQGRTTLFWTIIHRQTDIFRQLISMDHIDLNVRDGNGLTPLSHAAQYGNKEIIRMLLGEPGIDVEVEDDTGMTALGHAAKWGHSGAVELLLKEGNAKPLTRDKNGKTLLDLSLAERHFDAAQKVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDV8</accession>
    <name>S0EDV8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434928.1">
        <property type="nucleotide sequence ID" value="XM_023582387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDV8"/>
    <dbReference type="STRING" id="1279085.S0EDV8"/>
    <dbReference type="GeneID" id="35406201"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12745"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT72850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="545" mass="61206" checksum="5B98DF85A01102F8" modified="2013-09-18" version="1">MTIISLESNLVYISAVVVAFTLVVHLIRATSRWSDAPPGPPTVPILGNLHQIPQRETSISSTKDGERNVDGPIFSLKLGSQNMIVLTSGEMIKKLVDKRSGNYADRPKLYMQEVWEHSRIIMRGYDPLWKVERKLYHQFLNINRAARYAPYQDLETRQLCYDLLHQPGDFEALVTRATTSLATSMTYGFRVVSLESPVMKELFANTHGFFVMVRGSKLLDWFPQLRPMARLLPTWLNGVARKGKEIFSREKAHFHQLYKQVQVDADLGTAHPSFAADIYTAQKTWKDAAALDLLTDHAASYIAGIALEGGADTTSNTLAGLIKAMMLFPDVQRKVHEELDAVVGRDRYPTMDDFQSLPYVRQTVKEALRWLPTAINGAIPHAALADDEIDGFKIPAGTNVVLAVWCANNDARLFPNPREFDPSRHDPSKSLAEAAAAADYKQRDQWTFGAGRRICPGIHVAERTLFLATARLLWAFDIRKARGPDGLEIEVDRDEVTQSIAARPVPFRCEIKPRSEKHARLISEAWSQAREGLDKSGNYKEVAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDZ3</accession>
    <name>S0EDZ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432702.1">
        <property type="nucleotide sequence ID" value="XM_023579956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDZ3"/>
    <dbReference type="GeneID" id="35400089"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06612"/>
    <dbReference type="HOGENOM" id="CLU_2757966_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495826" evidence="1">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="70" mass="7693" checksum="E2657AFE483AB369" modified="2013-09-18" version="1">MKFSTIFLTIASVATAMAAALPEPEVEIPGKLVSRDEFELAIRRCCWLPIKESYGKENLNLAAAYSKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE53</accession>
    <name>S0EE53_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to quinate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_10092</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435304.1">
        <property type="nucleotide sequence ID" value="XM_023567933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EE53"/>
    <dbReference type="GeneID" id="35403559"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10092"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF42">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT73226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="531" mass="58449" checksum="146CF9AAE2A1179B" modified="2013-09-18" version="1">MGWNTHASGTNDPPEVRNWRIHLIATVASMSALAIGYDTSVIGGTMALTSFMRDFGLDLVEKTQRDTIQGNIVSTFQAGCFFGALLTFPIAEKWGRRKTIMGAALVFLLGGALMTAANGNLNMIYGGRAVAGLGLGASSLTVPVYISETAPPSIRGRLVGIFEIASQGGGMLGFWINYATDRTIDVNTKTQWIVPLAVQLLPGLGLALGMLWCPESPRWLARGDHFEAAEKILAQIRGLPAEHEYVRREMGDIRAQVEERSTNKMSKKQQFKKLFQKGVRNRMGIGMALMFLQSFTGVNIITYYAPRIFESLGIPGTSLKLFSTGFYGISKTLGMVLFTFWVVEKVGRRKGLIWGAALGCIPMWYIGGYVMEADPAAAAAAGVVNRDGWGYLAIVCVYINAIIICATWQGITWTYASEIFPLDIRMLCVAITTADTWLGSFIIARSTPYMISDLGYGAYFFFSSILVCMGIWATFFVPETKGITLEDMDALFAKPVYKTVWAQMRGKPVLEEHRPESPFEDDEKAHELRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEJ5</accession>
    <name>S0EEJ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435469.1">
        <property type="nucleotide sequence ID" value="XM_023568122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEJ5"/>
    <dbReference type="GeneID" id="35403389"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09922"/>
    <dbReference type="HOGENOM" id="CLU_035151_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="428" mass="49001" checksum="A70FCBA435A710B8" modified="2013-09-18" version="1">MALAVTDPFIRLPPELRVQVLVWTGCKASISRIIQASPTMLQQYVAHRKSILRQVLAAEFDPEMRQDAMAILLFPSRRSSGDKHQHKQLCRAHMLAWSKSQLLDPFKGNDDDLVGQLNELHDRILLFVEDYITKATASFPPQEYLCLPKVQPPSMEGHLMFKGLKVAPRFSSASLTSSERKRFVKAFLVFDLLCKNNTFAYVPSKPGPRKISNAEYEAVGCVHSYVCSLYGAMLAQCNHADLPTALAPPSWRTQLFSPVPDALFFDANVYAPNLRLLSRDRGDDIGDDILAGLSMLGLDRLTNFLRYNMAEPNEREVLDKKLKDVWKFGSPSISHPWESYFAVLLVTKRKYKNGRESSLYKRLSLKSEEKLRYKLGQERAWVFFDDNRFYPQESAEQPTFPSETFLAEQSAKKTFINDWFDSLRDRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEN0</accession>
    <name>S0EEN0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435292.1">
        <property type="nucleotide sequence ID" value="XM_023567920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEN0"/>
    <dbReference type="STRING" id="1279085.S0EEN0"/>
    <dbReference type="GeneID" id="35403571"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10104"/>
    <dbReference type="HOGENOM" id="CLU_022448_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="64731" checksum="42D83CC6480F8C33" modified="2013-09-18" version="1">MAETEKPEARFDGLGIFWIIWTFVWTFIVAGGMVFLWRRRDMPMLRIRDLPLSFAAIVLLHIYWGAIQTGYVYFPLFTPEGEFWIMSLYFPFGIALFHASNSRFLHVAKQQKELFASDEKSPSKSRVRRGSLLGRFQALDYSKKILITVGLGMVVQFILTIIMWCLSKKFHPSWGVPGTEVHPGSEEYRKSQVGKGWEWWPSVFWQFLWAWIVAPYILWQARGVNDTQGWRVQTVACCIANLHATPMWLIALYVPAMAPINYYWIPPQWLAISIMAIEIFTIFWPCWEVLQHQNLRQETLDSIAQWQLNKGTGTNGARSVATGSTTVAASALTSWSKDGSVKSSASGESILTMEALEYVLERNPEPLQQFSALRDFSGENIAFLRAVAEWKSSLPPAVRDPEKIKEPSVQELVRERFNSALRIYTGFISSRDAEFQINLSSQQQKVLEGVFETSARILYGDKKQVDPALPFEGFQMVTTPTKVKSSAASSHGSETGIMAADSVADTGYMSDKAMYWGDIPEGFDATIFDDSEKHIKYLVLTNTWPKFVKDRRCSIDSNDTLEAGNGISMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFM2</accession>
    <name>S0EFM2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435879.1">
        <property type="nucleotide sequence ID" value="XM_023568726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFM2"/>
    <dbReference type="GeneID" id="35402846"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09378"/>
    <dbReference type="HOGENOM" id="CLU_1320942_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22147" checksum="188EFA12AC890B29" modified="2013-09-18" version="1">MSTVEIICISTALMASGGIATLTFFDVPELQSQPASRSLPSIRWLFSRGSHVFPSASLLSTIGFVYSASCGSFSDSGSLLAISTKTPKTNTFLTAAALAFSIAPFTQLMIPTNFALIEENNRLGGVRSEKAAGGSASTDRSAWESVKGTDEGFEFADLSGPQEQTERESTAEEDKKVYELLERFRWLNLVRAALIGAGGVVGLYAAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFW1</accession>
    <name>S0EFW1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435969.1">
        <property type="nucleotide sequence ID" value="XM_023568833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFW1"/>
    <dbReference type="GeneID" id="35402751"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09282"/>
    <dbReference type="HOGENOM" id="CLU_2121288_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495954" evidence="1">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="114" mass="12324" checksum="989AF2938B3F7B25" modified="2013-09-18" version="1">MKFSTILLVLAPLVSAAASKEAAAGLPDLASASEKGHDLSSHGEGLQLAAKVCPAKFPRKCSLGNFCCRTLKCCKKDMHDTTMDGFGKVQRLERMPYTLGFSTLERNFDMIKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EG95</accession>
    <name>S0EG95_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to GLY1-L-threonine aldolase, low-specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_09364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435892.1">
        <property type="nucleotide sequence ID" value="XM_023568742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EG95"/>
    <dbReference type="STRING" id="1279085.S0EG95"/>
    <dbReference type="GeneID" id="35402833"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09364"/>
    <dbReference type="HOGENOM" id="CLU_049619_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF5">
        <property type="entry name" value="LOW SPECIFICITY L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT73814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="353" mass="38407" checksum="EAFD3F0F050B7FF5" modified="2013-09-18" version="1">MPSQIPTSIPRYSFMDDYSEGAHPALLKALITSNTTQETGYGGDTYCDLARQRIRRHLGRDDVGIFFVPSGTSANAISIAACLRPHEAVIAASSGHIVTRETGAVEASGHKIINVTPQNGKLTPATIERALDDNWHFPHMAKPRLVYISNATEIGTIYSRAELAAIKQVCEKNGLILFLDGARIGTALASKANDMTLSDILELTDIFWIGGTKNGALLGEAVVVKDARLSSEFEFYVKQHGSLLAKGRVIGAQFAELFEGDLYFELARKANLAAESLSSGIAQGGFSVYAATETNQVFAVLPLSLIKVLKESFSFYVWEKCGDDEAVIRLLTTWATEGAQVERFVEMVHSWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGE4</accession>
    <name>S0EGE4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to DNA-directed RNA polymerase small Zn-binding chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435798.1">
        <property type="nucleotide sequence ID" value="XM_023568633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGE4"/>
    <dbReference type="SMR" id="S0EGE4"/>
    <dbReference type="STRING" id="1279085.S0EGE4"/>
    <dbReference type="GeneID" id="35402930"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09462"/>
    <dbReference type="HOGENOM" id="CLU_179456_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="72" mass="7997" checksum="6E6DEDD0EED903FE" modified="2013-09-18" version="1">MPREEYQVPTANAGQRGGTRDDHQVRHVMSYICGDCGGSVTLGKDATVACPHCAGRVLYKERTKRMVQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGR4</accession>
    <name>S0EGR4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_08362</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433632.1">
        <property type="nucleotide sequence ID" value="XM_023580946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGR4"/>
    <dbReference type="STRING" id="1279085.S0EGR4"/>
    <dbReference type="GeneID" id="35401838"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08362"/>
    <dbReference type="HOGENOM" id="CLU_033546_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000056">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="115"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT71553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="461" mass="49784" checksum="C252D051C10503F4" modified="2013-09-18" version="1">MVRNIVVLGGNSHPQLTENVCQILGVPASNRILGKFSGGESRCEIKDSVRGKDVYIIQSGSGNVNDNLIDLCIMISACKTGSAKRVTAVVPLFPYSRQPDWPYNKAGAPLSQISGSSKDYTFESVPPTPRPGGPKSAGLPNGVNNLTEKLSKTALANEGATNGANGTNGVFSTPRRSDTISSSTSEARGHHAENSTSSQRNAYTTHDYENQSNISAFQPKPGYKQWIAQAGTLVADLLTCAGADHIITMDLHDPQYQGFFDIPVDNLYGKALLQNYIQSQIPNHHTAVIVSPDAGGAKRATLIADSLKTDFALIHKVIPQNSDFAAFENSCLATKERRPIRFTEHRNASMMLVGDVSNRICILVDDIVDTGNTITRAAKLLKKEGATQVYALVTHGVFSGDAIARINASAIDKMLVTNSVPQNEHRRLCPKLEILDISAVFAEAIRRVHHGESISVLFQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGX2</accession>
    <name>S0EGX2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435135.1">
        <property type="nucleotide sequence ID" value="XM_023581963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGX2"/>
    <dbReference type="STRING" id="1279085.S0EGX2"/>
    <dbReference type="GeneID" id="35405821"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12365"/>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="334" mass="37880" checksum="1BA20611D53D0BCD" modified="2013-09-18" version="1">MAQTQQVDLAALVPDYATKDTDSSLGEDLQSSSASVSSSILNYRRENGRTYHAYKDGKYALPNDEAENERLDLQHNLFLLTFDDKVSLSPPNKLDAKVKHVLDVGTGTGIWAIDYADEHPEAQVIGVDLSPIQPDFVPPNVNFVIDDIEDDWTFSQPFDYIHSRVMTSCIADWGDYLKKCFNNLVPGGYLEIQEVDVNIKSDDGSLRPDNIMLKSLALLNEASVMFGRPYLDILSLVNIIKNIDFEDVVVEKFKWPINSWPRDKKAKLLGSWCYTNMACGLEAFTMAPLTRAHGWTPEEVNLWLVHQRKAMADRNTHAYWPLYSIYGRKPLKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGX7</accession>
    <name>S0EGX7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435993.1">
        <property type="nucleotide sequence ID" value="XM_023568865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGX7"/>
    <dbReference type="STRING" id="1279085.S0EGX7"/>
    <dbReference type="GeneID" id="35402724"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09255"/>
    <dbReference type="HOGENOM" id="CLU_847434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="328" mass="36357" checksum="606760F8FA26F923" modified="2013-09-18" version="1">MTASREGSIDVVQLLLNHSADINIRNDQNETPLILAARLAHESLVLFLLGHCAHLDVADFRVWLHQMAVIRGSRWSTGVVHTILRHVTNICWAGEDGGRLLNVAAEWDDHEIAQLCLAKGVDINWKHPNGGTALAGAILKDRGRSPAPFLTYLRLPHDDRDIIKMQPGMIANKRAMVAVLLDHGADLNLSSESRDGSLRPPLVVAARQGLDWAVEELIKYGADCNARGMVRRKPEPRRHRLASAFRRTHIQEEPADLIHGGSALIYAFRSGQVSTVRLLLAYGANTSLVDENERTAFEWACAMAGFGRYDEIKQALMEHDEALGRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHJ1</accession>
    <name>S0EHJ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433937.1">
        <property type="nucleotide sequence ID" value="XM_023580385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHJ1"/>
    <dbReference type="GeneID" id="35402342"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08867"/>
    <dbReference type="HOGENOM" id="CLU_109017_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="221" mass="24317" checksum="2E72F3FF79884744" modified="2013-09-18" version="1">MVTLKRGMSYELLAKTPGLSFPSPTTPVSLSRICAEVFGGSDPLQKMTKAEVEDNICEFLTECDNHFHSLTICPIHHPLASACVCQEKMNYKHIASSLEKSWARPIDPGHVKAIVEATLSARIEVINENNGIKNDIKGAKSLILLNVHILLCIFAEFKHSHDCSLVNSLVWTITGAIDQKQEAQERKKTLLRQRKAKNDKSVSGAGDPSAADTAVAEERKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHT8</accession>
    <name>S0EHT8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435495.1">
        <property type="nucleotide sequence ID" value="XM_023568266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHT8"/>
    <dbReference type="STRING" id="1279085.S0EHT8"/>
    <dbReference type="GeneID" id="35403260"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09793"/>
    <dbReference type="HOGENOM" id="CLU_036529_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="296"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="400" mass="44070" checksum="B3BE506C0C6A5381" modified="2013-09-18" version="1">MSSRPRRSAATKANEVISVHARWADSPERSERSMSSRRSGRASGVSVSRDDASSPGGDRHLSLTVKLPSNKLRQATRGERGFEGGEIVSGKRNRGAKKSYVVDSSPDEDEEEEEEAEIEVEEDDDDEMDVDAEGEEDAEGDIDMDLAPPTITVSKPARSKPAPRASAAKVIQDDDDEDDELSDPADSDAGDETIGFGDETMADDGDEDAEGEEIEVAGQEGDEDDEDEEDEEEEDDEGDRGDDDDEDDDEDGNPDESIDLTKMTKRQRARFEDDNAHQYMKLSDEVQAKKVFTAEELSMRRQEMARRRRNLSEKRNEEVKMETINKLLKKQAPKINRKAAAAGAGGLEDSNKPDPVFVRWVSNKTGVRVAVTEEMLDSPAGQVFKPASKLAPGKMVQEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI11</accession>
    <name>S0EI11_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436507.1">
        <property type="nucleotide sequence ID" value="XM_023569269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI11"/>
    <dbReference type="GeneID" id="35403945"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10480"/>
    <dbReference type="HOGENOM" id="CLU_060567_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF1">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="299"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="401" mass="43831" checksum="7F55DF384DBBF8F0" modified="2013-09-18" version="1">MTYYGHNVNFQQQNPGYNQDGPGQGGYGGDDQRRNDQGGYQQGGPQQYGQQQGGYQQGGPQQGGYQQDRPGLSQSYYSESSQYPPGGQSGPGQYQQGPPAYNQGPQGQFDGGDGPDGERGVMGALAGGAAGAFGGHKMGGVTGHSKTSTIVGALAGAFGGHKLQDAAGDWKDERDEKKEEEKRRKEEEKRREEEEERRRKERRDDDRYESHHRRRSRSRSRSRSSSRGSNRRRGGHYAGNFTASSRDIRLDAHGDYVLHASCKREDGDYQHTSISLDKVLENDRGSFRWSAGGHHGSSSSVTVQQGDTLRGIAARFNCSFEEIARHNGINNPDLIYPGQTLQVPGGGRHGGGGFGSSARHVRLVDGGQRLEGELSRDGDWVLSSIILDERIRNFNGTLELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIK3</accession>
    <name>S0EIK3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to dienelactone hydrolase and related enzymes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436543.1">
        <property type="nucleotide sequence ID" value="XM_023569313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIK3"/>
    <dbReference type="STRING" id="1279085.S0EIK3"/>
    <dbReference type="GeneID" id="35403984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10520"/>
    <dbReference type="HOGENOM" id="CLU_032662_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="443" mass="49345" checksum="E4E3D810A8F9BE3C" modified="2013-09-18" version="1">MNINIPNLIKSAVPEAEGRNVQIISDNRTNHRDQNFLSGDFPRNPPKLYITGENDDFDEVTLAEWRDEGFDVEYISMESCGDGYLKKIKSLSRENLGPCEKFGIVAYDDAAAICLEHFHILDNNPEFKLGLLIAYYPTRIPDTNGKFPSSISALVHLAAGEEVGVVKQSQMVGIQGKKRVRRTKIQSGMGTGGKLDLAYPSYTYEAEPGFAEHDLDEYDAVSAELAWSRSLAAARKVFGINPDLELVLEHNLQSKFFSKNLGKALSTFTTHKTPHVTYMPTLTGATGAAELKRFYSESFTTPPSLKITLLSRTIGVDRVVDEMHVQFKHTEQVQWMLPGVPPTNKKIEILMVSIVAVRGGRLYQEHVYWDQASVLVQAGLLDPKLLPQSAKDLGLQKLPVVGRRAARRVLKNRDASDDEGEADNELIPGWNKQESEGSKNNQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ18</accession>
    <name>FUJ2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trans-enoyl reductase FFUJ_12240</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fujikurins biosynthesis cluster protein FFUJ_12240</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">FFUJ_12240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="J. Nat. Prod." volume="78" first="1809" last="1815">
            <title>Isolation and structure elucidation of fujikurins A-D: products of the PKS19 gene cluster in Fusarium fujikuroi.</title>
            <authorList>
                <person name="von Bargen K.W."/>
                <person name="Niehaus E.M."/>
                <person name="Krug I."/>
                <person name="Bergander K."/>
                <person name="Wuerthwein E.U."/>
                <person name="Tudzynski B."/>
                <person name="Humpf H.U."/>
            </authorList>
            <dbReference type="PubMed" id="26192387"/>
            <dbReference type="DOI" id="10.1021/np5008137"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of fujikurins A-D, secondary metabolites playing a role during rice infection (PubMed:23825955, PubMed:26192387). The polyketide synthase PKS19 acts with the trans-enoyl reductase FFUJ_12240 and the polyketide transferase FFUJ_12241 to produce fujikurins, however, the biosynthesis pathway has not been identified yet (PubMed:23825955, PubMed:26192387).</text>
    </comment>
    <comment type="induction">
        <text evidence="3">The fujikurins gene cluster is specifically expressed during rice infection (PubMed:23825955).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434456.1">
        <property type="nucleotide sequence ID" value="XM_023581822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ18"/>
    <dbReference type="SMR" id="S0EJ18"/>
    <dbReference type="STRING" id="1279085.S0EJ18"/>
    <dbReference type="EnsemblFungi" id="CCT72378">
        <property type="protein sequence ID" value="CCT72378"/>
        <property type="gene ID" value="FFUJ_12240"/>
    </dbReference>
    <dbReference type="GeneID" id="35405696"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12240"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF6">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE APDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000442009" description="Trans-enoyl reductase FFUJ_12240">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="124"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="180"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="335"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9Y7D0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="23825955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="26192387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="26192387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT72378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="346" mass="36683" checksum="0D0E46D261E5FEB4" modified="2013-09-18" version="1">MQALVGAETGGYRLADNVEKPVLQPGSILCHVKAVALNPHDAKIVDYSNVPGALGGCDFAGVVVEIGNGVKRFKEGDRVFAVTFGMNASDKTAGAFTQYAVATEDLSCLIPEAMSFTEACSMGLAIATAGLALFQTPGLQLSMQGGNGEAVLVSGGATATGTMAIQFLRIAGYTPVVTCSPSNNALCESFGAEICFDYHSPTCGADIRVQTGNKLRHVLDCVVDISTMKMSYDAIGSSGGAYVALEAIPTNIKYTRRDICANWLMAPSILGTPVNKKGAYGRPSMPEHRQFGTYLFALAEKWLQDGSIKHHPIEIREGGLRSIREGIDDLRRGNVHAKKLVYPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJA3</accession>
    <name>S0EJA3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DHHA1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436793.1">
        <property type="nucleotide sequence ID" value="XM_023569600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJA3"/>
    <dbReference type="STRING" id="1279085.S0EJA3"/>
    <dbReference type="GeneID" id="35404242"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10778"/>
    <dbReference type="HOGENOM" id="CLU_034130_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051673">
        <property type="entry name" value="SSDNA_exonuclease_RecJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255:SF2">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="48916" checksum="D22DC8E55F8A48CD" modified="2013-09-18" version="1">MLRLISAPSALKVYNAQISLLPISRKNGPCLTIVRQFQKSIVARKKFQYYPGAKPMFPEQDYHKAEPRRDQDGNVIWHAPKSQIERAKDFLRECAAAGKQTLIVPDKDADGLAAGAIIRKTLILLGLDSKLISCYTMNKNSSWKSEPVVDSPHRALVIDHHLAEDDDHPEGAILVTANKYPPIATSSLLTYLICRNLHEGVEESCGWLCVMGTNGDLGKATKWRSPFPNMEATFGTHTRTTINNSAKLINAPRRTAAYDVLRAWKILIKASSPIELVKNKFLKEARAKVIHEMKRADRVVPLFSADKKIAVIRIKSKAQIHALIAERQARQLFSRDLQVVMIANEGYARGVVNYSCRVPTCARGRDPPVNIPEILSRAADGTGDDTVRERLGPRFAVGHKNVSGGMIPQAAFEDFLEATGVSSDKKPSPSPKKSPKSSTNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJY9</accession>
    <name>S0EJY9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437152.1">
        <property type="nucleotide sequence ID" value="XM_023570022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJY9"/>
    <dbReference type="STRING" id="1279085.S0EJY9"/>
    <dbReference type="GeneID" id="35404619"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11155"/>
    <dbReference type="HOGENOM" id="CLU_023130_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="458" mass="50959" checksum="92347BCE9256EDF1" modified="2013-09-18" version="1">MSSTASQIDLSYPPASPSQHMTTPSRRQSCDRCHSQKLRCNPPGGRRTGACSRCFRHDTQCVYSLSRPKGRPSLHHYEGKTVLLPPTSRMEAVVQPLTPEEHDCASIQEPGLTYSLQLSTLPHAPETITPCQPDSEPILAPGPCFELMPEAWPDYALQPEVYSWDTMHARYQVTNSSISMFNTSMNMQHEFHDAMGDLCVPELQVGWHLETRGNLSQVGQLPLCSFKNAMEILGQLTPRVQALDNKSQEVFKNWGPSHKQGDFDQRLPMLLLNDAVLKLVMAWLNKPSEDMNDERSILNSLSSATNELRNDQVVVELLSCSAKLTKATQSLHEELGVRTNKAVCDNIVAQHLVVVCHMQLLSSFVAVLGALQEGAEVIQGNTTPGLADLRLAMVVQLSSYLFVRQCRVVDGYLEVESGPKSSAGYPNQRTEDGRVIQELMAGVHSRLAWFQSFWYGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL83</accession>
    <name>S0EL83_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437844.1">
        <property type="nucleotide sequence ID" value="XM_023570782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL83"/>
    <dbReference type="GeneID" id="35405299"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11838"/>
    <dbReference type="HOGENOM" id="CLU_028200_0_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="25"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="351" mass="39684" checksum="6FD8F49CBC18C3D9" modified="2013-09-18" version="1">MAGLQPDIYAAISITWVAAFLALSLRLKARRMTKMSLWFDDYFAIISLLFVTSYCSVTIYWTHSYKLGQSILTIADPTEANRIQDRSRLLLWICELLYASSIAFCKLSILCFYWRVFQYTSIRYAIIILLVAVSIWITIRTFMVLFHCVPIRAYWDKSIQGAKCPFNEANFFFATILVHTTMDCVILILPVIEVMKMTLPLSQKLAVVGLFTSGTIVCVASIFVLVHSKLYNPRTDDIPKDMAENMMWAAVEINMAVFSACLPMLRPIFRHFLPGLSTTEESAQAPISLPNVVLPGVRLTETRSKKRESRRSGMSNGLYDPELGVFHGFSDISSIRSVASRSDSESTPRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELP0</accession>
    <name>S0ELP0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435386.1">
        <property type="nucleotide sequence ID" value="XM_023568027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELP0"/>
    <dbReference type="STRING" id="1279085.S0ELP0"/>
    <dbReference type="MEROPS" id="S10.014"/>
    <dbReference type="GeneID" id="35403474"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10007"/>
    <dbReference type="HOGENOM" id="CLU_008523_12_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006530144" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="515" mass="57250" checksum="0E55723FE8571275" modified="2013-09-18" version="1">MGLKTALLSVLGFVALTNASVIHPRTSKPAHAQYYNKKTSPYYVPSTGIPDVSFDIGESYAGQIPVDWKKTGSKDPKFFYWFFPTVNPAGKDDVVIWFNGGPGCSSLEGLTQENGPFSWKYGTYKPVPNAWSWHKLANVIWVEYPIGTGFSTGHVTAKNNTETAAQFVEWWKNLVDTFGLQGKKLYVTGESYAGVYVPYVGAAMLDKKDTKYYNVKGALYYDPVMPYADKLRLDHAAFPGFFRHWESVFAIPDKNKKILDNDNEKCGLDKYRETHLTYPPPPAPWKPVQVKGCDITAHFEEVNTVINPCFNVYHVQDTCPVLWDVLGFPSVQYTPPGATLFFNIPGVRKAIHAPANPKEWASCSGPVFVGDDDRYDPAEHEKKFQTLVEKTNNVMIGSGMADYIITSNTTALAVQGLKWNGKQGFQTAPSAEFVVPIINNTESNVENWAGGSVQGSVHSERGFTLATVKTSGHMVPQYAPPAAFRQLEHMLGRVKSLTDAEPFSVNISTSFKWPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM26</accession>
    <name>S0EM26_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438124.1">
        <property type="nucleotide sequence ID" value="XM_023570987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM26"/>
    <dbReference type="STRING" id="1279085.S0EM26"/>
    <dbReference type="GeneID" id="35405482"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12022"/>
    <dbReference type="HOGENOM" id="CLU_030809_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="244" mass="26945" checksum="AFE5C2A66731B487" modified="2013-09-18" version="1">MSSDHHHVQVFTDVPAHLFRLLEVRLPQFITLLRRLQVTTFLTGKTDSARITVASDVPSQERSASSTIRHFTATYLDPFLGLETDMWLYSTSEDSRGAMPASPTLSPGEDALCRRGLRSGPTPTYEYDKFIFRIDKLPLPHELQPPSDMVWGSGTVRDCELAKARTRSRKLLLTLPSLFIKLKDATPVAWAFLASSARSPSAVEGLQRPSSELLCTKASAFSGDSFAAVDVAPDNASSQAMWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM52</accession>
    <name>S0EM52_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437952.1">
        <property type="nucleotide sequence ID" value="XM_023570909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM52"/>
    <dbReference type="GeneID" id="35405412"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11952"/>
    <dbReference type="HOGENOM" id="CLU_882935_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="315" mass="36132" checksum="905AB048E85E5C6E" modified="2013-09-18" version="1">MAIDLDPTYLTFCSHSLIEMYNWERHEIFCFLSNACVTHPVEATKEILIAAYKQFLSLCPLDREVPTDWVVEHNFKPINPKTLKLNAKYNPAQHIYRTITKEWEDKAVPNDQKSKFNVNLNSAWEHTSPDPARLPILGASDGVFYWNHYDLLGFILSLLKTDLEGAKKDNFFLPLTAVYGRWCAKIGGDRKTPDPPKSPKDTVFTGMADEQIGVGPVPTVFQCTWIKDKGVVYFALGSSIAGHNVNWSNKSEVGVWKEKLQRTRFDLLYNWNDIHTEWIDGKEWDFENSPTLNKSKRTGTHFGNCGETYPFLHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMA8</accession>
    <name>S0EMA8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438234.1">
        <property type="nucleotide sequence ID" value="XM_023571179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMA8"/>
    <dbReference type="STRING" id="1279085.S0EMA8"/>
    <dbReference type="GeneID" id="35407631"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14179"/>
    <dbReference type="HOGENOM" id="CLU_874498_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT76188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="318" mass="34650" checksum="9FDD48B880FA2961" modified="2013-09-18" version="1">MSSARLGSGNVLPLRTCTTVAWHLLDDLGNLHTCSAHWAPMSPVHESPLLPTRRRDESINTITRLHGSGKPNILDATCFVLGITNMPIVQASKGRELLFPNGSGKSNIGVMASRQGLQQRCILVPEDEQTRDCCSHATGSGGRGDDGILCQIEITPSQVVITSTTAIAAGLEASTDKHICRCRDCLEVACLRSWERQEPSLRYPQTLLEILEDAAAVQEATRLDLGPYTLPSPIKAACKHHHSTPYRRQGSQWRARFVSPSSNQETLHSRPLFLSSSFTPKMPLLRVPYLSESPRIASRTTTSIVTYVAETAADAGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EME2</accession>
    <name>S0EME2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to hexose transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_12048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438037.1">
        <property type="nucleotide sequence ID" value="XM_023571015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EME2"/>
    <dbReference type="GeneID" id="35405508"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12048"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="512" mass="56656" checksum="36E042670456BD52" modified="2013-09-18" version="1">MPPKQHREQSLLASVLPKEQKPWYRISYLVQLNLLLLIPLMSSSVAGFDGSLMNGLQALPSWKNKFGNPQGHTLGFVNAAQSFGSILALPFCGTLSDRIGRKNTLLLGGLIIVVASVIQAAAINYGMFVASRVLVGMGAITIIQPSPMLISELCYPSHRGVYTALFWTFYYFGSIIAAWSTYGLQKHMPDSVWAWRGPSILQGALPILQMVFWWKLPESPRWLVANNRADEARVTLAKYHAGGDASSPLVNFEMNEIVTAIELDRHAQDVKWSALVATPGNRKRVLISFLLGLFSQWVGNSVVSYYLTLVLDTVGVKNPDTQTLINGLLQLFNFFAAILAAFLVDKLGRRTLWNWSGVGMLISFIIWTICSARFEINQSNGLGIAVIAFIFIYFFHYDIAYTPLVLAYPTEILQYSIRSKGLSLAFIAIYSSLIILSFVNPIALQAIGWKYYIVFSSITAVSVVVNYFLLPETKGLSLEEIEGLFDDKDVSDGGIGSSKLEGGEVSHVDVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMJ7</accession>
    <name>S0EMJ7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_09597</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435676.1">
        <property type="nucleotide sequence ID" value="XM_023568482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMJ7"/>
    <dbReference type="STRING" id="1279085.S0EMJ7"/>
    <dbReference type="GeneID" id="35403065"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09597"/>
    <dbReference type="HOGENOM" id="CLU_008539_6_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000063">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT73598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="562" mass="61241" checksum="7FAE3A91AF5EFDB5" modified="2013-09-18" version="1">MSSPQANESDPLLSGDGDGRSDAQADKGARNSRLRELGLFAWALIATAAVIVLAIWTQHEQQTKHDHNTPASKRNLVFMVSDGMGPAPLSLTRSFRQHVEELPYGDTLTLDKHFWGTSRTRSSSSLVTDSAAGATAFSCGKKTYNGAISTLPNHDPCGTVLEAAKRAGYHTGLVVTTKIEDATPACFNSHVVLREMEDEIALQQIGEGVLGRTVDLMLGGGRCNFLPNSTEGSCRADDTDVIKIAKEKHNWTYTDSRAGFDALKGGNNVKLPLLGLFAPTDIPFEIDRRNHNDVYPSLSEMAKTALRALEKATEKSDKGFFIMIEGSRIDHAGHINDPAAQVHEVLEYDKTFQAVLDFIKESKTETVLVATSDHETGGLATAIQEPGHLPVYNWYPKVLANATASAEWLHAKLNAHLASDSNIKKNKEKLKTYINEELIVGGLGISNASDKEITTIADHPESALVLFSALISLRAHVGWSTHGHTAVDVNIYSSGGPRTENIRGNVENTDVGKYLREYLEVDVDAITSELKEKMSKVNLQDVGMEALDEVWSLGNKYHAIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMP3</accession>
    <name>S0EMP3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435746.1">
        <property type="nucleotide sequence ID" value="XM_023568568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMP3"/>
    <dbReference type="GeneID" id="35402988"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09520"/>
    <dbReference type="HOGENOM" id="CLU_1959764_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="128" mass="14014" checksum="B2350DC5ED77CD08" modified="2013-09-18" version="1">MDADPRNRSSSKSREMPSGSQRVDLNASQYFNVHSGGILRQSISQRNSSILAKGISPPLSDSSNCPLFLQRYSGNLPGILSNQPANQILSHSLAGSQYPYLPLFITIPEDLVTSVQAKHAQRQMAYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMU7</accession>
    <name>S0EMU7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione reductase</fullName>
            <ecNumber evidence="3">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_11284</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437315.1">
        <property type="nucleotide sequence ID" value="XM_023570165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMU7"/>
    <dbReference type="STRING" id="1279085.S0EMU7"/>
    <dbReference type="GeneID" id="35404746"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11284"/>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="17">
        <location>
            <begin position="9"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="17">
        <location>
            <begin position="241"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="16">
        <location>
            <begin position="322"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT75260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="433" mass="47522" checksum="34FABAF287047F27" modified="2013-09-18" version="1">MATATRHCDFLVIGGGSGGLASARRASGRYGAKVIVVEAKRLGGTCVNVGCIPKKITWNAANLAQGLRDAKSYGFSVEQRAPFDWASFKNKRDAIIKNLNNIHKRNLEKDSVEYMHGRARLVGKNESMIKLHDGTEIKVNAKKILIATGGHPTVPRGIPGAEYGINSDGFFELDHQPKKVALIGAGYIAVEFAGMLNALGTETYLFIRHDKFLRTFDEMIQDEILSEYERVGIHIHKNSKAIGRTPEVEGLGLDIVGIKQNERGQIITDEYQNTNVENIYSLGDVVGKIELTPVAIAAGRKLGDRLFGGERFHNSKLDYNLIPSVVFAHPEVGTIGLTQEKAEKKYGRDNIKIYKTSFTATYYTIMEDRGPSRYKLICQGKDERVVGLHILGLGSGEILQGFGVAIKMGATKKDFDSCVAIHPTSAEELVTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENP6</accession>
    <name>S0ENP6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436351.1">
        <property type="nucleotide sequence ID" value="XM_023569089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENP6"/>
    <dbReference type="GeneID" id="35403784"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10319"/>
    <dbReference type="HOGENOM" id="CLU_044226_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="163"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="385" mass="43408" checksum="8688343F9F40FC27" modified="2013-09-18" version="1">MAPPSDGLSSIHYRPLDLAAREVRILELQPSPNNDINDRIVCRLVHEKLCDAPDFIGLSALYGDITKTEPIQLNGQRVAIPSDLAEAIRYTREVFLGPRAQSVINNASSSRVDLETEKTISNHQQQQQPSPPPSPTKKPPGWLRSFLRKLVDPGSARCDKPPLRIWIDLLCINRRDRKEEAERRAHMARAYREAKLVVGWLGPKDATSDLAIEIIRAWDKCMPANFGEPGDREANPANYAPILQWMGPVAHLSDIPEGITDPTEVPSYKAISGFLNRPYFRNTWILDDIAQAQFPTFMVGDGIVSWMQILRLNRVNEDIKDHGAEMFPSELRPLLEYMPLGSVYTFLKEFDRRQKLEGFRPVFSNTPASSIRSSASMTGLKTKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHQ1</accession>
    <name>S0DHQ1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_02025</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423577.1">
        <property type="nucleotide sequence ID" value="XM_023578561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHQ1"/>
    <dbReference type="SMR" id="S0DHQ1"/>
    <dbReference type="STRING" id="1279085.S0DHQ1"/>
    <dbReference type="GeneID" id="35395508"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02025"/>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_1"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484948" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="671"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT61496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="766" mass="84025" checksum="D90A000BD9C03F9F" modified="2013-09-18" version="1">MLLNLQVAASALSLSLLNGLAEAATPYTLPDCTKEPLSKNGICDTSLSPAKRAAALVAALTPEEKVGNLVSNATGAPRIGLPRYNWWNEALHGLAGSPGGRFADTPPYNAATSFPMPLLMAAAFDDDLIHDIGNVVGTEARAFTNGGWRGVDFWTPNVNPFKDPRWGRGSETPGEDALHVSRYARYIVRGLEGDKEQRRIVATCKHYAGNDFEDWGGFTRHDFDAKITPQDLAEYYVRPFQECTRDAKVGSIMCAYNAVNGIPACANSYLQETILRGHWNWTRDNNWITSDCGAMQDIWQNHKYVKTNAEGAQVAFENGMDSSCEYTTTSDVSDSYKQGLLTEKLMDRSLKRLFEGLVHTGFFDGSKAQWNSLSFADVNTKEAQDLALRSAVEGAVLLKNDGTLPLKLKKKDSVAMIGFWANDTSKLQGGYSGRAPFLHSPLYAAGKLGLDTNVAWGPTLQNSSSHDNWTVNAVAAAKKSDYILYFGGLDASAAGEDRDRENLDWPESQLTLLQKLSSLGKPLVVIQLGDQVDDTALLKNKKINSILWVNYPGQDGGTAVMDLLTGRKSPAGRLPVTQYPSKYTEQIGMTDMDLRPTKSLPGRTYRWYSTPVLPYGFGLHYTTFKAEFKANKLTFDIQKLLKGCSAQYSDTCALPPLQLSVKNTGRIASDFVSLVFIKSEVGPKPYPLKTLAAYGRLHDVAPSSTKDISLEWTLDNIARRGENGDLVVYPGTYTLLLDEPTQAKVQVTLTGKQATLDNWPQDPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI66</accession>
    <name>S0DI66_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_01460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424110.1">
        <property type="nucleotide sequence ID" value="XM_023578462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI66"/>
    <dbReference type="GeneID" id="35394945"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01460"/>
    <dbReference type="HOGENOM" id="CLU_030573_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="438"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT62029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="554" mass="61098" checksum="782415FF55C39190" modified="2013-09-18" version="1">MAGRVTGLSRHQRPPPLLSQIRGYEKRKLEQQPDDVNALPMSSEDEAEDDIPSPADLRLRPSGSQAQTPIEQSDDSEPETSARGDIKRTAFRNPSSSKSRRNSTRKVNQKEEETSKTGSHAETSSSSVKRRKLGSSKSGNGSHFEDTYGFPNAGSSKAKYGSSQPRGSQASRGSQSSQVKKGKAKVTKGELINEKTEEDDFLHSSQTEEKPTFKPVSQESFSSPTTSKVSLRLAPQDDLGTPKKKGSIERKPTSRGLSTTPTKSQVAHTATKLSQDGPSRSRSSSQNRMGVWKPVPLPKKSGGRLKTPEYKPPTFVAPAEIDGMQTSNSDIGSISSPVLSDLDELSDTETINEEPLADKNSLDDRVTKCPWCGDLVSEQTLKDYSKGKRLNVQMQTRFCAKHKKETAMDTWRERGYPHVDWSHLEGRLDDHRAYLTKIVNGKQSFFRDILAEKIETGQARSLKKEGNLNPGYYGPRGCKLMCDYLVEEFGESLKENATKDRVIAGRGSAAFIQSVLVAELAVQLIMEDMDVSASEAREIMEESKALGELIHEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI95</accession>
    <name>S0DI95_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine-protein phosphatase non-receptor type 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423966.1">
        <property type="nucleotide sequence ID" value="XM_023576706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI95"/>
    <dbReference type="STRING" id="1279085.S0DI95"/>
    <dbReference type="GeneID" id="35395103"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01618"/>
    <dbReference type="HOGENOM" id="CLU_029046_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="70217" checksum="0C5AA31BA88E9CC0" modified="2013-09-18" version="1">MNSVAHSMAETSPAPAAPPMQHQHQHQHQQPQPPPSPSPSQPTSVSETAPTPSLPSISSPSAQSASLPAVLAAATAVASVSVHSLAQNPDELPPLRQPSPTSPAHYTFEQHQQQQHHHPHHNLHPVTPPLRKDTCSSISTQATSATLASTETSNTSYSADTSPNLHQSIFSIKDGSDVSNNRRTCRRRTGPLSQQSRERAALIRKLGACIDCRRRRVACHPSHHNMTWEDVVTKFHRSHSPTIQNIAPSLAAAGRPLSPAPAISNVQALFHDTQEMDIDSSTPGSNLPGRPPLSDARIRTPLPSGPRLEKSLSLPGIESFKNDLQSNVGRMLSTPSRDRYSSVQVLFLFWQDDEEVPIIQTAVRELAEVFDKYYRYNFQVQAIPSSSDGCKSSWRWLSRALNEFVEDRDERDVLKIVYYAGHTYLDGNREMVLASSRNPEQASTIRWGGIQQTLEEACADTLIIMDAAYYPSSRMVRQQGVLELLAASVSEEHYYDLDRCAFTRALAEQLRVRAARLSPLSAAELHANLFSQYAKMVQDKYPEKEVLTSFPSPLHMMMSGNSRLPSIFLSPVCQNSPTQGSFSSYENSPQLHLSIRLDDDNVDLESWNEWLRLMPEGIRDVKVEGPFRATFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ12</accession>
    <name>S0DJ12_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_01187</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424356.1">
        <property type="nucleotide sequence ID" value="XM_023581528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJ12"/>
    <dbReference type="STRING" id="1279085.S0DJ12"/>
    <dbReference type="GeneID" id="35394672"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01187"/>
    <dbReference type="HOGENOM" id="CLU_079191_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000003">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="9">
        <location>
            <begin position="46"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="10">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT62275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="214" mass="24010" checksum="EF6A6DAA4FCA36E3" modified="2013-09-18" version="1">MYGDLGNKLVQHAKRTQNLTHLPPYQTEIVRAVTREVRDLDKDVAELLEPFQGSFDPSADQDIACTLLVNHLSMRRNKRCLLAYHRTRTDKLEELVWNGSDVVDLSGQQVRDPASASGAGGSDASKSSLSPQEEEYVRQYSDLLAAYKGQWTDIDLTGSLEPPRDLFIDVRVLKDAGEIQTEYGAITLTKNSQFYVRQGDVERLIAQGYLHKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK87</accession>
    <name>S0DK87_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423833.1">
        <property type="nucleotide sequence ID" value="XM_023575095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK87"/>
    <dbReference type="STRING" id="1279085.S0DK87"/>
    <dbReference type="GeneID" id="35395247"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01763"/>
    <dbReference type="HOGENOM" id="CLU_063749_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000024">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT61752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="202" mass="22147" checksum="DA45142165E7872A" modified="2013-09-18" version="1">MAFLILVIGDLHIPDRALDIPAKFKKLLSPGKISQTLCLGNLTDKHTYEYLRSVSPDLKIVKGRYDVEATSLPLTQVVTHGSLRIGFLEGFTLVSNEPDLLLAEANKLDVDVLCWGGTHRFDAFEYMDKFFVNPGSATGAFIEGSGLESEEPTPSFCLMDVQGISLTLYVYQLRKDDKGNENVAVEKVTYTKPVEPSAGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKB1</accession>
    <name>S0DKB1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NOP7</name>
        <name evidence="7" type="ORF">FFUJ_00548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKB1"/>
    <dbReference type="STRING" id="1279085.S0DKB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00548"/>
    <dbReference type="HOGENOM" id="CLU_019619_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="359"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="661" mass="74175" checksum="640BE26E859D584F" modified="2013-09-18" version="1">MPRIKKKGKAGAAKNYVTRNQAIRKLQISLPDFRKLCIWKGIYPREPRSRKKVSKSSTSSTTFYYTKDIQYLLHEPLLQKFRDQKVLEKKISRALGRGDVTDAARLEGNASRPEKTGKPRYTLDHVIRERYPTFIDAIRDLDDCLSMLFLFANLPSTSSVPAKMIARCERLCLEFQHYLIVSQSVTKSFLSIKGIYYQANIQGEEVLWLVPYKFNQRVVGDVDFRIMGTFVEFYMTLLGFVNFRLYTSLGLKYPPKFDQAKDEAGAELGAFTLEGKTLVGADGKEQKTLEAAEHKPDPKVQAAVNKVIKKIKGNDDDESTTTSENQVEGEVQEAGVIDKFEPAVSGGDILPQPSNTGNNPNSLFSNLTIYLSRETPRQPLEFLLKSFGCRRVGWDAVLGDGAFTTNELDPNITHQIVDRPPIQASADDEADGDDNQTSQKLAANRRVPGRTYIQPQWVWDSVNDGELKEPHLYAPGADLPPHLSPFVRNVQGAYDPTVPLEEQEPEAEAIEAQSDGEDEVDDTAEGMDVADSDEGEGDEGDEGDEFGGFSADEQEEEEEEEEDVEQRQDELEAELTGGAVKSKTTNAKAKAKEDARKALTKKAREEAEDLERAKGMLSKKKRKLYEQMVYTNNKKSAEDQKLRAKRRKFEKEKATKGKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKC6</accession>
    <name>S0DKC6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable RAX1 Protein involved in determination of budding patterns</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423888.1">
        <property type="nucleotide sequence ID" value="XM_023575761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKC6"/>
    <dbReference type="STRING" id="1279085.S0DKC6"/>
    <dbReference type="GeneID" id="35395188"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01703"/>
    <dbReference type="HOGENOM" id="CLU_029881_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="172"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="363" mass="41104" checksum="30BBDE6AB0099B4F" modified="2013-09-18" version="1">MAEHEPVTTMASPSPQPDMTRNRLPTLFEVLSRRTLPPVDLFSFYIYMRDQQRSVDYLDFWLDVAQHMSLCRHYVRELRRSVLIGTPEAQSKRSSAILENIGDLEPRTAGPSMYATEKEKNQDAQMSAFLREDQSHDSPQSASAPVRPSPQFSNSHEVTTESNSPAHTVARQDIRASAEKILYTFLLPGAEREITLPGSITAEVTTAIEEYGRDDPEVFDVAKDYVFQAMERDAFPGFLRMKALGNLIPPTLIMRLILGLIAMFAALWAAFVLIFLDYSRATRCWLILPFTVGVYFLASYQYSLDPIMALVGYSEYTPFNFSRIREPYVRKLIAKRAIMVLAVTVLIDAALCVLFILVPGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL78</accession>
    <name>S0DL78_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to RNA binding protein Pym</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424173.1">
        <property type="nucleotide sequence ID" value="XM_023579273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL78"/>
    <dbReference type="STRING" id="1279085.S0DL78"/>
    <dbReference type="GeneID" id="35394874"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01389"/>
    <dbReference type="HOGENOM" id="CLU_074603_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="192" mass="21128" checksum="4B6B906ABF65842B" modified="2013-09-18" version="1">MPSQPSNAGIVTDENSGDREIPQSVRADGSTRKAIKIRPGYRPPEDVEVYKNRTAEAFRERGKKIGIPGATGLKEESSEQNSAASNKNAKRREARKKAKAAEGDTPALAEETKPEEVDPEVEREKKARNLKKKLKQAKDLKNKKEGGEALLPEQIAKVIKINELIRELDALGFDAEGEPKKAATDDEGEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLT0</accession>
    <name>S0DLT0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to 26s proteasome subunit p28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425482.1">
        <property type="nucleotide sequence ID" value="XM_023577639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLT0"/>
    <dbReference type="STRING" id="1279085.S0DLT0"/>
    <dbReference type="GeneID" id="35395019"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01534"/>
    <dbReference type="HOGENOM" id="CLU_000134_18_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904855">
        <property type="term" value="F:proteasome regulatory particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="235" mass="25523" checksum="BFF683CE1C54400D" modified="2013-09-18" version="1">MDTDDKFPLHAAAREGRVTAFEGLLKSDPKLSQRKDNDGRYPIHWAASSNNLDIVQLLANQRSFDADVQDESGWSPLMISASVPEGEAVVKLIMSKDADVNLKNSAGQTALHFVASKKNLDIARVLIDNGASTRVRDRRGQYPIHRAAAVGSVPMVTLLLKNRSPLNLADNEGFTPLHHAIAEGHGDTAVALLKEGADFTLKNSADELALDLAPDKEVRRYVLQGAEREGIELPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM64</accession>
    <name>S0DM64_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT63525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425606.1">
        <property type="nucleotide sequence ID" value="XM_023577717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM64"/>
    <dbReference type="GeneID" id="35395012"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01527"/>
    <dbReference type="HOGENOM" id="CLU_119592_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="149" mass="16673" checksum="D98037105DC6FEB2" modified="2013-09-18" version="1">MLEATAETVDLGPVHPPKEDSITAFEQILPELKKTLVHLRHDYNKHEPEYFAAAEHLSDQDLVGFSADDFEAVRVATSAYGIHLFGKLRIPALPDPSGPSYIHFRVFIGGGGEPPKLHSIHTEEREDSSGGKTYRAIFTKNDELEWFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM94</accession>
    <name>S0DM94_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT63550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1279085.S0DM94"/>
    <dbReference type="GeneID" id="35398790"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05309"/>
    <dbReference type="HOGENOM" id="CLU_012285_1_0_1"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
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        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="980" mass="109519" checksum="527F357FF653B690" modified="2013-09-18" version="1">MNRQQRPNLKNGVDLQLQSAFNDGNWAAVIRLAEKRARTFNDQYYEIVKICAESQLDDPSSKFAAITAIDKYVREGTVVKDAEAIDLLEWASQGLNSEEDFPETLGPLRARLVKAAPKDKINASRCLESCLLHWDLVSAQQIAAILDRTFPQERSFMFWNIVITHLLATSPQSPPEKKKLYGMLALKQIQRAAQLAEEAATTGSEDAKPQPRSIQTEEEILLLYDVTEKHGSKDDLAKLVSSPVFSPFVQFRKGRKELMLRTISRYQQGQQFEAIFELCKDCLSIEDESGQPSLMAADWKVWRQFIEAAAEIKNTKPDVEETVQQLLLKFIKSPNLRPIYKRIILLARVSAAFNLASNDEDDLIENEPASFRLKELISYVKSQGTNVACFDDIKAFAERLNPPALKYMAYEFVPKLAQAAEDEIQSARISNLTFKLQYFAATCPSMYSTIPGEKPLRKCLVTGVEVDPNSPGPAFSTIAETALKAHQSLSDLTSKSSAIEAEIRPELAVIIGLSIIQTAFPPSTDISNTPVSYAPLLQALLLLEHQLSLTPKHSIISLLLVQLHLRVGSSSRAREIWDTLGVKRTIMDSLAPIFYDRLSTISPALISPSDETGWELLDLLSSHFNVSLKLRMPRRLIDAFESGSYSSVIDIPEYMENLRWSCTRAMSLVEETRTDRIMGEHFSEVFTDPRFTEVADDMKLVETVDYGSFPSWDSSSQPPVYSRLRIGPPPTNRRAHLSLLSEAFHELLGYKPPPIYKASATAAVPDQIFVLESLSQLGNSFMKFSNGPRGDLTPQEATYFEVISLLSTLIPFATGINRAKPIPEEFFQIVDTLKIAIDTLKLELLPLANASEQVTTLSTLHSLAILRDTSAAIKNSAQWVIGFNDREKERDRSGRSNLPKEVMAQIKEVVTASETALKDGKATVAKMKEQVYGRDFEPAVRAWIFEDADNILGIVGGAATKKLVKSWESNVKGWTQVVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DME2</accession>
    <name>S0DME2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable GATA type zinc finger protein asd4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_05048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425875.1">
        <property type="nucleotide sequence ID" value="XM_023571593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DME2"/>
    <dbReference type="STRING" id="1279085.S0DME2"/>
    <dbReference type="GeneID" id="35398529"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05048"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056998">
        <property type="entry name" value="Asd-4/GZF3_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF338">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25026">
        <property type="entry name" value="Asd-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="457"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT63794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="507" mass="53482" checksum="DF3D053AADF1E1D1" modified="2013-09-18" version="1">MEEDGAQLLQQTGLDPISRPDSTSTSASASLPHVLPGISALAAANAATEATSQLRASAAPSPAMYATASPAATSGGSGSTMPTCQNCSTSTTPLWRRDEFGSVLCNACGLFLKLHGRPRPISLKTDVIKSRNRVKTMRPDLANKKKQQQQQQQAAAQGFPTTDANGFDTTGQAAAAAAHAAQAARRASQRSNGHDGADSPISRTGTPSMYAHGLSQFMVDDPYQTGFVATGEGRASSPTNGDRKMDAPQTHEQLIAHNSSLKTRVSELEVIIELFRGRLSQLEQQEAVVRSGQQLNQLRSQLEQTQESEAQLRRQLEDSHRRESSLKRRLDDLELELQAFQGASLAPGERPAKRPRTLEEPTKTQAEADIEAAAEALLASEASRPSEAVESAPVVDAPEPTELPQHSEGSKEDSVPKTDNEIEAADVPIDPNMPVIDDVSQPAAAEETTKTEDVEIPDAPDASEAPSAPEAAEAAYVAATAEASATDDASPEATEGTETPAPATAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNF6</accession>
    <name>S0DNF6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426051.1">
        <property type="nucleotide sequence ID" value="XM_023571809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNF6"/>
    <dbReference type="STRING" id="1279085.S0DNF6"/>
    <dbReference type="GeneID" id="35398336"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04855"/>
    <dbReference type="HOGENOM" id="CLU_010101_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="809" mass="90684" checksum="95C26759D34BC887" modified="2013-09-18" version="1">MALWPFRRRSSRKRSRSGAAFSDAEGAPLPHNEGPKLGLKKRRTEPPRLQGAGRTYSFSPGRQDDIRTDRHRAGSPVRERTGRTRTTGNLEERSELWDRTPTLRPTHQATRKQRSKRRKEERNREAEIKAMSNFAPVRPATEQWNSGRPMKKDSKRSKTGGFGRHRAGRNSDVSLPVPGSIHSSLSSDSEFGSYRVSALAALAPRPTLRYTPNARWTTPHVPTPHRSGSLRRKLLEQEPIPEETTRSHRRIDSLADDLDARDLRELMEIDNRRRELKKQKERQRMERRITQRAEKQQAEQIQARNTGTPPPENLERGVMGRELVGLGIDPASAVVTETKPEDPEPMDITEDEREIEFPKKTEEVCHHTDTAASEQPTPMEEVITKDTSSMRQPSEDMGSVSPGTRFSDLLRSAKSRSRSTIRSDRDRMVSPPPETINEEDVHMPRYNSHDSDGSKNGFASIKAFLRIGSKRQRREGPSSFANTSREEMQAAAAQSRAQAQAYALAKLEGEDSPNSSSGNYLSRKPSIGAPKRTRSRFREDLPELPLSPPASRVQSPEAEPPMPILTEQKIREMEELRSLGVRYDTPTSGHRSAEAMRRTPSTVERAYVSPSPEAGMSMSLASIDSEGSWLSGNASGRRAAIRDSIRRANQREQNDAHTDSPTNSTEENLEIVEDEYLTKLTPRRNSNPEFMGRRSGEGRPSSDEEEFATDGEMKWGAVGSQPQVVHRFTMKSHEGLLELESEDEESPTSPVSPSQELANVQSARSVNLGKGHVRNFSAGSAKLLDLTPRPSVDATGNSERRRSHVQPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPE4</accession>
    <name>S0DPE4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426392.1">
        <property type="nucleotide sequence ID" value="XM_023572229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPE4"/>
    <dbReference type="STRING" id="1279085.S0DPE4"/>
    <dbReference type="GeneID" id="35397961"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04480"/>
    <dbReference type="HOGENOM" id="CLU_557330_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="546" mass="61831" checksum="C2145CE03F195B92" modified="2013-09-18" version="1">MEFRERSFSRGTDERLPKPTTRMNDETWERFKPFLCNLYKKYTLSVVMNVMEKKYGIVQSKRQYGYRFEKWGIKKYNANEKKTSHNSLSPGGINDSMDYGDIGAEFDRGAHSFNQYPMPDRCGPDTLMAAVGSEIIECDESLDSHRAAKVVVPYPWATGSSEEANKLAADFCAAMLDDTNAFALYASLYEVLSNSQSVPETREFLAICCARVAGKPDNARSARAILAREWTGTPTTRVSDSPFVLSMLKAYVGSHQEDSDKSAFVKQISRNVEQLVGSDGSLGEVSHKYSSIDLVAYFFLDYALEIYDDCFDDSNPPNFMTEHLLNEFITTQPFMNALRNDCPSPLSLCLRWCKEQLRLNHAVALQDAPVQPSTDMRCWWYNIRVFCTLWGVMTHLVRANCAPAWYTQCESAFGIPPSELLITLSWMIRAEATATETDRIISDTELLTQAADGADKLLQVDESQLWIDFLKRFTWMNELANPGDAERSFEAAVQDELRKYVSKMLRVELPHPAGTQSTSVGGGVDFYSFPQHGFPDFDINSQMDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQE7</accession>
    <name>S0DQE7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426885.1">
        <property type="nucleotide sequence ID" value="XM_023572830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQE7"/>
    <dbReference type="STRING" id="1279085.S0DQE7"/>
    <dbReference type="GeneID" id="35397423"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03942"/>
    <dbReference type="HOGENOM" id="CLU_007091_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF130">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTO (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="691" mass="77961" checksum="77B0277A899B5C02" modified="2013-09-18" version="1">MNRLPTNSQRVVKPGVKKRRPPLACVQCYQRKLKCGRELPACSRCSKAGNADECIYRGDKGRHTSADGLSNDGPSGASSALERSSTETLGKHAASASHEVDMTHLEGQGNSTKFYGYSYPLNLYQQFADLRPYIIKVKAQYPSINTLRDEIYAPFNEKHRRRQILPDDALENTLRELIPTKSIMDVLVQTYIDRFEITHRILHIPTFITKYNSHWTDQSSTSTPVCFLVQMLLVAATAVSCHPEVCINVFSHKTNHDHVIKWIEATEAWVSSYFNQTPRSWDVLATHCLLLIAKRANFLKEGSFWTSTGTLVRWAMAAGYHREVISAARMSPFDREMRRRLWITVVELDLQASIERGMPPSVRIGDFNIETPLNVDDERLKESVQGSLAGMPITKLTNTSFQALLYRSLSVRLRICAFINGSCEDVDFDKILELEEELGQALRGIPAFDNPQADPRQHQTATYIKSMLGIVLHQYILLLHFHFVVHSPSSSKAVICRRARLEASMKILDYYQRLLNDEALPGQACRTGLVLAALSICHEIYLNIGSRACDQTTMTIFPQVSAFLIENIEKVLNILEKRISLTFNGLNEYYILSMTVGLVKSKLGPESSAKSDQEAAERVIKLCTILQTRQAAIRQEQPFSEACDDGESHANQISIDASYMESDIMTDLISSILPQDLDFINDNLDLTFFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQF8</accession>
    <name>S0DQF8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426895.1">
        <property type="nucleotide sequence ID" value="XM_023572842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQF8"/>
    <dbReference type="STRING" id="1279085.S0DQF8"/>
    <dbReference type="GeneID" id="35397412"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03931"/>
    <dbReference type="HOGENOM" id="CLU_1042245_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT64814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="267" mass="29714" checksum="E2C7FB747087288D" modified="2013-09-18" version="1">MEEDTVKYFAEMFKKWGISSNSTEAEPPKPSCDMYAYGADAECMELFAASFCDNVKGDKNKAVSRNLTYDDVVGDAKRAVATGAKRRSLWRRQSKCLSHEFDFEWTGGDGSCDLSCSKAYSQLQSQCHRSLYFAGLAKKGSIDKGCGTYSYGVSKKADSASTTLPSATSQAKTKTADPKPITTDVKFEIHNLQCNNEDDFRGHVDISSGAAYDVIFDACTHSDKENLYMTPESEPYVKEFKDTDSHKHRVTWSWIDGCSMKNEKVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQR9</accession>
    <name>S0DQR9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to signal peptide protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426995.1">
        <property type="nucleotide sequence ID" value="XM_023572963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQR9"/>
    <dbReference type="STRING" id="1279085.S0DQR9"/>
    <dbReference type="GeneID" id="35397303"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03822"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="250" mass="27221" checksum="8D65D24A1622D1F2" modified="2013-09-18" version="1">MSNPTIVFAPGAWHTADCYDVVRKELHAKGWETEAVDYPSVGAEPPTKGLSDDVAAVRTVVEKLAEEGKKVMVVVHSYGGLVGAEAVKGLGLKQRVQEGKTGGVIQLVYLSAFVMPKGVSILAALGGQYLPWMRVEGDYVYADTPENIFYHDVDPETQTKAIAALKHQSRRVYTDNVEYEPWHDVPCFFIFCDEDRAIPLAIQENLASTLGPNAGSFHIKSSHSPFLSLPKETVEGLEKAAQDGLTKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQW2</accession>
    <name>S0DQW2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426921.1">
        <property type="nucleotide sequence ID" value="XM_023572876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQW2"/>
    <dbReference type="STRING" id="1279085.S0DQW2"/>
    <dbReference type="GeneID" id="35397382"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03901"/>
    <dbReference type="HOGENOM" id="CLU_1015776_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485182" evidence="2">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="285" mass="30160" checksum="0B32FD3D15AB4B0D" modified="2013-09-18" version="1">MIPQTYIAAFITACLVGGSQAGPCKPSSRIIESSIASDTSTTVGSTTTVGSTTTSSFVDTTMVAASSTVTSNEESSVIITGLSSTERSQSPEETSTTALSTTDGITTEIATTTEAATPTNTATTSEVPSAIPFITNAGFDDDTSSIAPWELFNGLEVTVSIASDVKHDGRNSALFTQGQRPLIDFIRQPLRGSITAGVAYTMSAWVNANLFCPAVELICSYRNTYWEETDAIDLTTSVDEWKHVTSTCTYTQEQIDSGDLYFMIGFHCIGNGGRGYIDTVDFAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQY0</accession>
    <name>S0DQY0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to DUF1275 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425029.1">
        <property type="nucleotide sequence ID" value="XM_023573283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQY0"/>
    <dbReference type="STRING" id="1279085.S0DQY0"/>
    <dbReference type="GeneID" id="35393932"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00447"/>
    <dbReference type="HOGENOM" id="CLU_061825_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF1">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="274" mass="29597" checksum="50BA04CF0A53DB8F" modified="2013-09-18" version="1">MVRAVDRGVRNTVVRDEETPLLGSSLSGPQKKSWKEHLQHNVSCSWADAVLLACYVVTGLLDSSSIQVWGTFVSMQTGNTVYVGLGLASFATSTPGPRLYKSALSIASFCLGSFLFARFHRLVSPRRRWVLCASFTIQALLTSTAALIVTLRPPGPNTDSLAWNVLVPIALMAFQSCGQAVASRALKQNALISLVLTSVYCDLFSDRELFALDNVSRNQRAAAPTLLLVGVIAGGLFAQSSVGIAGALWIAAGLKLCMVIAWFLWRSEEETEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR63</accession>
    <name>S0DR63_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427027.1">
        <property type="nucleotide sequence ID" value="XM_023573002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR63"/>
    <dbReference type="STRING" id="1279085.S0DR63"/>
    <dbReference type="GeneID" id="35397268"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03787"/>
    <dbReference type="HOGENOM" id="CLU_011429_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1022" mass="115761" checksum="1CF0457946684F30" modified="2013-09-18" version="1">MGGRLSNDFDMHDDDHFLSLMRMFNEDKEHVDDLRISFPAWVERYCDYSHTKHAQTGNHGLSDTSLDIQRKMGVLINKMWTVKMEDPVHLSQYCAFRSFKELGSYVDVIVPDIIWKAAFVAHDYFCVPKDCEVMRGASQAEQDFQKLVKPLHKECYNSRTQHLQTFAIEIDRIAPIRVLVTYHRNEKVREFIDKVAKLCTKPTLIPVLNQTVSTPGLPGNISPCAFILAHAVQILLFAPQDWDANRVYTRDQDAYAHRFPTPETIGGGTTPTVAGLFSMEDLHRAILLFYYLLKRRSERKWITKKAPARSSKAGFPGYHHPTSPSVDHGAHHNPNEPPAGETSPSASDWGPQANEVDAVADNNEPDDSDKDEGESGQPEEDANESEGVLEDENEEESESAPHQSGEYNSESNQGDEDENGDGRVNEDEDADMSEGLNETETIEGLKTITINTLILESLTTTRPSESLSQRLWDLGKPKAPPISSGNLDSELLFLLEHHMQPEFEYEASTSIKNDTHVPFDLGIPEMKHLIKHPSGTPENSEINQPSPLVLVEECHYQWGIPQYPEINDSCPAQPPGQGNHPISEYPELRKAVLTSFDWRNKILLELEEPPFLATFENAKSVMKGLLDPEIAKYQIEGFGSEDATPLIDTYKLLRDDQTCGLRLLFDQAMGQRSRLAPTDRMDCIRWVCYYNPIMTRALELANKYCRDNKERLVVYVEDPWIQCITVALFVVAGFNVGSIRSSDTGKEQVKIMEQWKNKASGLEILVANVDTKVGDINPHTDCAKGLLLNWTLEPERMLKIINDMSSTSQKEKPILHMVKVAGSYHDVIERVCCTKWAMQLSKDIKLPEWMTGIIREICIFELIKSTWHQEFNRYAWVVAYDLKGPDFEYHDPEWRQLGHVFSIVAKLALHHPEDKEFWVESMPILIELCFHFNGAFDMSDLLGCRLCLTPKEMRKWCLPMFKAIKIARAALDDEQASARREMLQLGVEARAGYHEAVTRGGQKRKAGDDGGGGAKKQKTSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRF8</accession>
    <name>S0DRF8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to DUF803 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426073.1">
        <property type="nucleotide sequence ID" value="XM_023571834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRF8"/>
    <dbReference type="STRING" id="1279085.S0DRF8"/>
    <dbReference type="GeneID" id="35398313"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04832"/>
    <dbReference type="HOGENOM" id="CLU_012349_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="620" mass="68117" checksum="F8443EB1493C64BC" modified="2013-09-18" version="1">MDADIFVRSGGLGGDPSDRPGFYKPVGIGLAVGSGVFIGISFVLKKVGLLRANEKYNEVAGEGYGYLKNFYWWAGMTLMIIGEILNFVAYAFTDAILVTPLGALSVVITAILSAIFLKERLSMVGKVACFLCIVGSVVIVMNAPHTSSVSDIQEMQKYFITPGFLTYAGLIIVGSIATALWAGPRYGNKNMLVYISICSWIGGLSVVSTQGLGAAIIAWIGGKPQYKEWFLWVLFVFVIGTLLTEIIYLNKALNIYNAALVTPTYYVYFTSTTIITSAILFQGFKGTAQSIVTVVLGFLTICSGVVLLQLSKSAKDVPDAAVFSGDLDQIQTIAEQEQPESEPKADAIRGAAAIVRQISQRRLRMEAEELKRLHEEKMMMDTMDPIREDGQQPEWEWDGLRRRRTMTFRTGTISSSRAGSVTSPPPPMPPASPRFAVRPSSPRHPPLGMSQFPPVEDGDDSDDDNRQETNTLFSSIAGTIRGRARGFTNFSGRHANDDHEDDKPRPRSPMHPVPLTEIAVPRDKADEEHAAYYGQTREHEYNGQDTEYRGASFRSGDSLAPPTPPPHGQPQDTTRRQFSFHNVFRRPHSSSRSTSHVADPTEEERAGLVKDDSQPGPSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRH8</accession>
    <name>S0DRH8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1479 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427116.1">
        <property type="nucleotide sequence ID" value="XM_023572078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRH8"/>
    <dbReference type="STRING" id="1279085.S0DRH8"/>
    <dbReference type="GeneID" id="35398096"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04615"/>
    <dbReference type="HOGENOM" id="CLU_011148_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="844" mass="90882" checksum="081FBC78CA8AED4E" modified="2013-09-18" version="1">MATPTIDLPPTTCEEEVTTPILDNAQGLASAIGAAAAVAAVAVGDGLTHGLGGVAYGKPYDGHISEEDGQFHDVDHRGAREAKQQKSLREAQEKWDAATIGPVTRVETVIAAEGGGGDGRGEREVWEGGGGGGPEGVQLPPRKGADVAGQQVRAALSRSRLSRSNPSCSGSSSGSLSGASLHNATNTAVAAPAIASNNSPNNLNFIQTGRVTKSRHRSSLSAPIAASLVNAAATESARLSYEAKLTAALAANIAGTMAGSQSSTTTTALPSLKSNGLSSLPQKPKTNGTTPTFSTASSMDKDAPVISFWGPEPIALPSRFARIKRNLISGHEAELEASWARLITALRKEVSHIEDLGAHLIPSIEFGDLDDSVQTARFGHDLRRYGVGVVRKVVPRADTDTAVRETVDYLDSKRHIKALQQHDPACFDFFWTPAQVRSRAHPNVLSAQRFMMSLWETNPDDQLVTRLPITYVDRIRVHGNGENQSNSLNVPPLEPPQSADDWIQALQSSAGITAQVDNGSLERWEPDGYQRAGTYNHIFHGQWEDYDPWKCTSRTSVTTDLYNGYGACTIFRMFQGILALSTVEPGMVRLLPSPKLATAYYLLRPFFTAKNPPPENRTGPEWEAYLAPENWKLQTEPDSIIHGAVPGHAQRITETWHPHLHLRNSMITLPTLQPGDYIFWHPDLPYYLSSNNYGLKTPSGSKSEVSMLVYIPAAPLTQTNALYLARQRKAFQRGHPGPDFDSTGRGIVEEDAETRPGEKEIAEVGGPSSLQAMGLAPWEVAGTRSGSPPSEKSKSKADEDVEMEGDGDTKSLTSTSSISRAEAEVVRLANIILFPDRSMLGYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRS5</accession>
    <name>S0DRS5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_04742</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426158.1">
        <property type="nucleotide sequence ID" value="XM_023571935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRS5"/>
    <dbReference type="STRING" id="1279085.S0DRS5"/>
    <dbReference type="GeneID" id="35398223"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04742"/>
    <dbReference type="HOGENOM" id="CLU_031067_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038074">
        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT64077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="425" mass="48317" checksum="FF656FD52B5EBFC8" modified="2013-09-18" version="1">MEFVTALRGTFDEQKPSLFEVLSEQQLNALLPPTLRYLLTIATHRHPRYLLRILNSFDEIYAGVMLLVERHYLRTRGGSFTENFYGLKREKGLHAEVPRASMSSPDIVRETLKLTTRDVWKNLLVIVGIPYLKRKLDESYEVNAPRALLGAAYTRMPDNPTLRDRFLYYYRWFLRNIYPSVNAGYYFAMLAFNVAYLFDGSKYHSPLLWLIGTRIRRMSGADYKAIEALTQTPETGHRPGWRSLLNPREMGPRVLSSLSILLPTSIFALKFLEWWYQSDFAKQLSRKATESVDLPPPVISADGKGGSGKKKPEVKKEESNEGDSTPSAEDAPIATPSLLPVYTIPFPSDSALCPICVDEIVTPTACQTGVVYCYTCIHKWIEGQHQKQEDFMESREGKWESGQGRCAVTGRRVLGGTEGLRRIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS14</accession>
    <name>S0DS14_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable brt1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427311.1">
        <property type="nucleotide sequence ID" value="XM_023573857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS14"/>
    <dbReference type="STRING" id="1279085.S0DS14"/>
    <dbReference type="GeneID" id="35395641"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02159"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="130" mass="13966" checksum="560942FC2AD37F4A" modified="2013-09-18" version="1">MSGFEAVYTPDACAPLPQFSQAVKYNGMVYCSGSIGIDPATDDLVPGSVTDRARMALKNLQVVLGAAGSSLDRVVKANVFLADMKDFGAFNTAWDEFFPTEPKPCRTCVAVHQLPLNTDVEIEVTAGYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSF7</accession>
    <name>S0DSF7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427575.1">
        <property type="nucleotide sequence ID" value="XM_023574168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSF7"/>
    <dbReference type="STRING" id="1279085.S0DSF7"/>
    <dbReference type="GeneID" id="35395920"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02438"/>
    <dbReference type="HOGENOM" id="CLU_026305_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="180"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="565" mass="63499" checksum="1D87117C6D21D865" modified="2013-09-18" version="1">MSGLEIAGLILGAIPVAIEALKSGSQGIAMLQRSRRYENELERLVNKLENERVRLGDVCEKVLVDLVPHSRMEEMIQDPGRMFNDDPELKAKLQRRLWKGFDLFNQTLKEINAAMNEAINRISLQIQDESNIRRSLRHSFLDDLLSRINEGVLVLEQLVDRSIQLEPTRNRRLQGKFLCFVRNLACELSCALRASFHCTCGHQICLQLERRSPDMVPGDTGDEAAKHIGFHLALSYQGPSTKPDIISSRDTMWSDVLAKPSLMSRPEALTITIQPKQKDRLKAFRENSSPIYSRSFSSPMDGSAKLQANSVELKSVVNHPQRSTRTVDLCNSITRPLEPGTETSYGMIFDVSTPETYAYHVSSVILSKYRAQCGRTITSLNGVLGQNRQHMILSEQDRLKLAVVISSNLLQLHGSPWMPKVIRSQDIYLIQSDDDPICDRFFVMQTLPNKTGSCIEENAELRSMRNQALFYLGVLLIELAFGKSLELLRSARDKSSTGSQFFTDYRTAKRLVDQVTSFIGPNYGSAVSRCIDGEFHGRGVGLEDQDLSQDVYAGVVALLEKELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTF4</accession>
    <name>S0DTF4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_02667</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427781.1">
        <property type="nucleotide sequence ID" value="XM_023574425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTF4"/>
    <dbReference type="STRING" id="1279085.S0DTF4"/>
    <dbReference type="GeneID" id="35396149"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02667"/>
    <dbReference type="HOGENOM" id="CLU_022618_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="328"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT65700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="572" mass="62718" checksum="1F661E6F3B39D256" modified="2013-09-18" version="1">MASHDYYSGGSQQAPYGAGPNASPYYQNHETPSPHSTPAPPYEPNSYNSHYAPDTSIYPADTAAHIVPTKQTPYSPNDIQYPPAGTYASPSGQSSSHNQPGQTGQSPFDTVFDDHVYPANSNTGPTPSSSTADIGQQGFYQDTSYAGGAAAARPYGQEDIPLQDRTAKNDDPEMNDHIYDAPGRSKKKGKKGKVRLGELGMIGSNKKRIPWVVYIFSVVQIAVFIAEIARMGVLTGTPIAIKPQFNVFIGPSPGLLINMGARYAPCMRNVKGIQSVDKNAKDAVLPGLLCPNATRDDSFCPLHVVCGFGGDVPDPKFNGDINQSPEPNQWYRFITSIFMHAGLIHIIFNLLLQLTIAKEMEMAIGPVRFLLVYMSAGIFGNIMGGNYAPPGQPSVGASGALFGIIALVLLDLLYSWKDRRNPVKDLLFIILDMVIAFVLGLLPGLDNFVHIGGFLMGLSLGVCVLHSPNSLRRRMGQELSYAAVSPQTGETPPHFFKNPVGFFKGRKPLWWAWWLVRAAFLVMIIVVFIVLLNNFYKYHDTCDWCKYLNCLPINDWCDWGSFEHLKEPKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTG2</accession>
    <name>S0DTG2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_02712</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427822.1">
        <property type="nucleotide sequence ID" value="XM_023574477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTG2"/>
    <dbReference type="STRING" id="1279085.S0DTG2"/>
    <dbReference type="GeneID" id="35396194"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02712"/>
    <dbReference type="HOGENOM" id="CLU_014931_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000552">
        <property type="entry name" value="Probable mitochondrial carrier protein ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="340"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="438"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="536"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT65741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="695" mass="76797" checksum="111C1040C9618B92" modified="2013-09-18" version="1">MSKLAVAKEAVKEAVIGTHEPEQLAAHTKARFTKHAIKDPETGELFLGPDEFINAVVPEGEDYHKISRDQYSILFSVADVNGKGKVSLADWGIFEHLLNKPDAEYQIAFRLFDVERTGSVKYDDFRTLYELNKGPDNLTFDWESDWAKIYIGNKKHRHPLDYPQFCQMLRGLQGERIRQAFHQLDKDGDGFISGEEFERIIVETARHKLSEHILDNLHTLVNLSIGSKISYANVRAFQNVIGGMDLVELILRRAIDQSKDGKITRPEFLNEAAKLTRFSLFTPMEADILFHFAGLDEPSGRLGLSDFAKVLDPSWRNPIYDAVEATKAKVAGGGILMGVLTSGYNFALGSVAGAFGAFMVYPIDLVKTRLQNQRGAQPGQRLYKNSIDCFQKVIRNEGFRGLYSGVLPQLVGVAPEKAIKLTVNDLARKYFTDKNGNITVLSEMISGGSAGACQVVFTNPLEIVKIRLQVQGEVAKTVEGTPKRSAMWIVRNLGLVGLYKGASACLLRDVPFSAIYFPTYSHLKKDFFGESPTNKLGVLQLLTAGAIAGMPAAYLTTPCDVIKTRLQVEARKGEATYNGLRHAAKTIWKEEGFTAFFKGGPARIFRSSPQFGFTLAAYEVLQTLLPMPGTQKEKIPTGVSDAVSTVKGSLDTSPYGRSRNALKVILDLDEDFGKVKLPNEKGWRSLPKIMGGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTM8</accession>
    <name>S0DTM8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427887.1">
        <property type="nucleotide sequence ID" value="XM_023574552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTM8"/>
    <dbReference type="GeneID" id="35396262"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02780"/>
    <dbReference type="HOGENOM" id="CLU_131051_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="167" mass="18983" checksum="59B2F19FF1FBB886" modified="2013-09-18" version="1">MAPTEDIFARDYYRCRYGQTWNGRTCVRNNWSYWGRWVLAGIIIFFFVLLLSCCLFSRRRKRRGVKPVYGTGWMAAKPWGNNNNHQMYNYGNQGGYNQGYQQNNGGYGAPPPPPAYGQQQQPQYTGTTFNTNDGYYGQGQYSGVQQPQGTYQREGAYSPPAGPPPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU53</accession>
    <name>S0DU53_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to cellobiose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_03807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427008.1">
        <property type="nucleotide sequence ID" value="XM_023572980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU53"/>
    <dbReference type="STRING" id="1279085.S0DU53"/>
    <dbReference type="GeneID" id="35397288"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03807"/>
    <dbReference type="HOGENOM" id="CLU_011025_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12831">
        <property type="entry name" value="FAD_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495197" evidence="4">
        <location>
            <begin position="18"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="761"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT64927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="801" mass="85197" checksum="45CDB0D407C7C24B" modified="2013-09-18" version="1">MRFTLSSMAGLLGLASAQGLRSSAYTDPKTGIDFQRFVDDGYSLGIAVPETLGKDLIAQMVFPREKEGWGGISFRGGMVGGMLFVAWPNGDDIVTSFRMANSYANPDVYTNSTVKATPIPDGTFINSTHVSYTFLCEGCVVKETTSLTGESPVVGYAWSSIDVDTPSDPESALNYHGAGFGQFGLDIKKAASAKFATWAAMAKETTPAPGTGTPGVPGNSTTLPPTTSNVTYDVIVVGGGPAGIIAAERLAESGASVLLIERGPANTVALGNAAQALPWNNTLTPYDIPALGSSMTSMSGTKFCSDTASTAGCLLGGSSSINGLNFIHPPERDFQRWPKGWSWADLSKAADRLYERNPGTTSPSDDGKYYDDRTYTILSGYLSAKGWKEVDSIEEPNEKHLVYSRPSWSIKNNMRAGPARTYMPFAKNLPNFTLKLETKVIQPIRTGSKITGVLTQGANGSKQIINVKAGGKVVLAAGAMSTPRLLWNAGIGKSDALAIVKQGASKTGVTLPAASDFIDLPVGHHLQDHAQVMLQFKTKSNFTAYKFNNIATEPVKSDLELYYQGSGPITQAAQRMHLWTSAKGADGRVRYLQGTASAMADGIITVRTFLTHGTSTVGELGITAGGNTVLNTKPWLIDQEDRKAMADFVQYWLDLTSGSNSTLSYITPGATVDDILATKMISGDHWMGSAKMGVDDGRKANGSAVVDLNTKVYGTDNLFVVDASMHPDLPTGNTQAIIMVAAEHAAEKIAALKVGGSNSTVPEPISSAPTPVPTPGSKCKRGLRRRRAARVPMDFRRRSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU96</accession>
    <name>S0DU96_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to gibberellin 20-oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428235.1">
        <property type="nucleotide sequence ID" value="XM_023574969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU96"/>
    <dbReference type="STRING" id="1279085.S0DU96"/>
    <dbReference type="GeneID" id="35396636"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03154"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000030">
        <property type="entry name" value="Thymine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF804">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="186"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="335" mass="37202" checksum="925AD7E69ACC3AE7" modified="2013-09-18" version="1">MASGLAVSKEGLSIPLIDFSRFLGGTPVERNETANAILDGFKTAGFIYLKNHPILPKDLQHAFDLSARFFKEPLEKKMEVVWTTPEANRGYSAPGREKVSQLKDIQEVEKVRAALPDLKESLEIGREDEPGRPNRWLEETGDLVGFRKDMLGFFEKCRQLHVEVMKAIAVGMGLDDSFFDSFVDVGDNTLRLLHYPAVESNIFKAKPGTVRAGAHSDYGSITLLFQDARGGLQVKSPTGQFVDATPIEGTVVVNAGDLLARWSNDTIKSTIHRVVEPPQKQAESYPPRYSIAYFCNPNFKSYIEAIPGTFSTEKDKKYEVGFVKNIMATHTGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUA2</accession>
    <name>S0DUA2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to ELMO2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428101.1">
        <property type="nucleotide sequence ID" value="XM_023574812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUA2"/>
    <dbReference type="STRING" id="1279085.S0DUA2"/>
    <dbReference type="GeneID" id="35396495"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03013"/>
    <dbReference type="HOGENOM" id="CLU_009191_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="259"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="715" mass="80196" checksum="BC013C2B2A2733E7" modified="2013-09-18" version="1">MDQADIPALLARMASDEDASRKMAVFKLQNSINDPAFADVFISSGGLVVLRRLIMTSAGNTLAYSLQSLTRLLEVDMGWDIFEGPTASDLVERVVELIVTNPLVNILRGAMSILVALVGHSQSTNQSDVANRTPGTFGFRALKPAVAVHPNFFELVIQQLQSADHALCANALMLINALIRDAVSGESTTNGGKANAGSGEDWAKFIKRLQDLGLIKAVHRLMQSSALQDLAHPMLEFQTLTKILLRKWREVDVDLERPEHRRALKGLHLASAPERAHVNGHSPGQESHEAPGKKGSRRHNPEKWRRLGFETESPAQEFDMTGFLGMMDLSDYVRRNEDGFQKLLLEQAGKPTPERCPVARASFAVTMILYDHFDVDKTDLDDVRGYQLLEAKDHDRLFRPLLLQWSRLHTAGLYTFFRVWKLTGAEQGDFEKVVELVRILIDCVVGGATRTKDVAEVEEEMQEYDVPRLREQQMCLLEMSFESTWGQHLQQVREELKQEALQFVKEQRIRCLLQGSWFSKPAPKRDNGAVKHRLFTPTPWRYAKLSHNRRYLHYADFEERTVTAPGLDSLGEKVDLSTISSVVSNVSAPNEDTRSTMSDLMGKDATPKTTTKITVYSFVNATEAARGTDSKEQPIFTLWPLSHSLASEWLDGLLMLLNQAPITAETNKLVNLVSEYGLKIRLLNVRMDTAFEGPEPGAGVIPSREGLDEDYFFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUJ8</accession>
    <name>S0DUJ8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426309.1">
        <property type="nucleotide sequence ID" value="XM_023572124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUJ8"/>
    <dbReference type="STRING" id="1279085.S0DUJ8"/>
    <dbReference type="GeneID" id="35398055"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04574"/>
    <dbReference type="HOGENOM" id="CLU_024934_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT64228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="428" mass="47717" checksum="3C6BB3FF1199F7D5" modified="2013-09-18" version="1">MSSRRTHTKSRTGCINCKKRKVKCDEARPSCFHCTRHGVTCSLASQPLTSLGISSVDGSSDSRSSYFPNLSPSDSTPAPTLSSLDSHHLVNSPDPFGSYSHPSPTQQIAPFPPHELWARDCELMHHYCTVTADTLCVRKDLAYVWGVAIPRLGYQDPFVMHGILAIAAAHKAYLVPDNRKTYLPLADYHQTLGSEGYRRYLQHYSMTNWMPVFGFASLVVLHMLTLPTRMNNCALEDPITNLIELAGLLRGIKTTLEPAMGRIVKTEFAPVVFGIWGLDSDDEAERCPSLENSSLPTDTWTALQRLRAFQEADIPASGLQHYTSAVEGLETSARLFAAAGLHAEVAATHFWLYIIDDSILIDLAAQRPHALLLFAHYLVHWAVFEKGFWFTRGWSRQVMAKLEEGLTGRPNFLGMMQWPKQMVAEAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUS6</accession>
    <name>S0DUS6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_03226</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428297.1">
        <property type="nucleotide sequence ID" value="XM_023575049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUS6"/>
    <dbReference type="STRING" id="1279085.S0DUS6"/>
    <dbReference type="GeneID" id="35396708"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03226"/>
    <dbReference type="HOGENOM" id="CLU_163540_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="12">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT66216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="93" mass="10447" checksum="1E406010B0963837" modified="2013-09-18" version="1">MPQYTSRDVGDPSQIKKNKQSMADLKLRRLTELNNRLREDLERERIPVSTASKSIIAYCNGTRDYMVPSVWGAVPKGEDPYAPQQSGGCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DW70</accession>
    <name>S0DW70_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to PHD finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_03039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428801.1">
        <property type="nucleotide sequence ID" value="XM_023574841.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DW70"/>
    <dbReference type="GeneID" id="35396521"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03039"/>
    <dbReference type="HOGENOM" id="CLU_001514_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15497">
        <property type="entry name" value="PHD1_Snt2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000018">
        <property type="entry name" value="Lid2 complex component snt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000486">
        <property type="entry name" value="PHD finger and BAH domain (Snt2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000899">
        <property type="entry name" value="PHD finger and BAH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="9">
        <location>
            <begin position="205"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="360"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="10">
        <location>
            <begin position="501"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="924"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="556"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="851"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1216"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1308"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1349"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1391"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1003"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1216"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1308"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1333"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1395"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1511"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1534"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1570"/>
            <end position="1580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT66720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1586" mass="175430" checksum="9AE79474868E54AB" modified="2013-09-18" version="1">MAQHNDSNASDPGAQSMPEPMTNQSSLDSAAKEAGADSAFPYGTRSRNRTGTSRINYAEDRDIDGDVYDYYHDKKDSDSKKTSRQSSAAVNGDAPRGGASSRKAGTDEPKAAQAANAPKEQRLGSSNNLPTATQQPAASQPARKRKVAGNTAGSINPATSVNNSTKKAAASGTTPSIVWPETNMLTFDNCKSRPVNGKMVADDGTSLEPNDHVYLVCEPPGEPYYLGRIMEFLHVQNDSSKPVEAVRINWYYRPKDIGRKSTDLRMVFATMHSDISPLTALRGKCQIHHKAEIEDMELYRKAHDTFWYDKLYDRYIQKNYDLIPTRSIVNVPANVKKVLDERWKYVLVEQGRGKELTSAVKLCKRCAGYCASNDSVDCAVCQNTYHMNCVNPPLLKKPSRGFAWSCAACSRAQERKLEARNTPNVNDPSFDAEDDDPMDEEDEEMQGLETNRTSPEEGEHTHHEGTAEQIYQASLWPYRYLGMHCKPEDALDYDDRIYPRASTRIGPRNQANVSPWPGKPVEYVKPLEIKKNGKKDTKSKEALAAIEADKISRGKRPKWVQDMPPGYTARGEDFDDDDPKCTATRMWIPPPEKVIKEKDINEYMEKAKGMAKDLGLPERSTNLQDVAANKLFLAEFNMEHALKDLSETKKEAFKEPELTPTEQKKFEEAVIKYGSELYLVRKHVKTMHYGMVTRYYYAWKKSARGKQVLENQAGRKGKKEAKRAEAAASKLADDVADNDDDSAFDIEKASQKKQGFMCQFCSTTFSRQWRRAPNPVPGIVNDGGSKNSNKEKGQERVVALCRRCAELWRRYAIRYEDVDEVSKKVNQGSGRSWKRKQDEDLLRELQVAKEMGMMTPERAPTPSTTPATAAVQEPPRKKLKGAASDKDVDNGHSDAASAAGSTTSKKKDKSVENLSVPAIPKPLVLPCAVCGQLEPQGDQHLSCRECRLTVHRNCYGIMDNRNSGKWTCDMCANDKNPQVSIHYKCVLCPIEYTEHDFVEQPKITHHKKKMSEKDRERERLEVQQARKAADFYRKKQEEMNRPINPREPLKRTADNNWVHVTCAVWTPEVKFGNAKALEPSEGIPSIPRSRYDETCQVCNKQDGACVSCHQCRIPFHAECARQHGHVLGFEVTSVKSTRRDQFNIVAINGESGIMSATVWCKDHAPTKTTIHQMQDIVDELGLNALQLYVQNYKQADLALTGTVRKANLMTNAAKLSGTTTQPGLRRSSTTNIPNGGWGPQRNGDTGDVASESKQPGEKVCITCGIDTSPKWWPIDNSQERELTNGHYGTLGSEAQKFVEQRRFQCHKCRKAQRTAKPHPRRSPLMAEAPLPTTHGSGIQGTTTHVLRSPPQMVPAPRETNPSAAYAWPPPVHAPTVPPPPMQAPALVADHALGARPPPPAPYAPLPPQRPSYSDWGRPASQQGSPPRHINGGPPIHNAPPMSTLSSLRPPPAVGPGPALGSSPPAPPPANHHGGPASQPYTNGLPPSPRRLNGPAPPPRYTHPYQTHGHNAPPPPPPASHLPPTLTNGVPPPPPRHDGFSHELHPQRPPYPAPHGSPTGPRNGPQPPSSRPASGASASPSLRNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX39</accession>
    <name>S0DX39_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_13316</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429210.1">
        <property type="nucleotide sequence ID" value="XM_023575988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX39"/>
    <dbReference type="STRING" id="1279085.S0DX39"/>
    <dbReference type="GeneID" id="35406770"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13316"/>
    <dbReference type="HOGENOM" id="CLU_091077_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT67129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="177" mass="17942" checksum="FF2DFCED0EEE3A0F" modified="2013-09-18" version="1">MNFPGMTPPGGAAAPPAIGGPQDPNVKAVQSAMESCFGKSVMSGVMGFGMGGLFGMFMASMSYDTPYHTAAPGSPQSTITSLPLKQQLKIGFKDMGTRSWSMAKNFGKVGALYSGVECGIEGLRAKNDLTNSVAAGCLTGGILAKNAGPQAAAGGCLAFAAFSAAIDAYMRSPPKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXB7</accession>
    <name>S0DXB7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Urease accessory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429257.1">
        <property type="nucleotide sequence ID" value="XM_023576046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXB7"/>
    <dbReference type="STRING" id="1279085.S0DXB7"/>
    <dbReference type="GeneID" id="35406822"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13368"/>
    <dbReference type="HOGENOM" id="CLU_049215_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30859" checksum="19FE4751BA94BAFA" modified="2013-09-18" version="1">MSSQIQAPNTANVIQDEIHELEKRLEDAKARLNKVLPSPPLSTVIEPHLASTTHFLLLLSDSALPLGSFAFSSGLESYLAHEPRASASFASFLPSSLSSFAATTLPFVLAAHRDPGSLPQLDDQLDAAIICTVGRRASVAQGRALLGIWERSFRASCPDVDGQPLRDFAALLRRESQNEVPLISAHLAPLFGAICALVGLGLRQTAYVFMLSHVKALISAAVRASVFGPYQAQKVLAGQQVQTMIDDMIDREWNTSVEEAGQTVPLMDLWIGRHETLYSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXC7</accession>
    <name>S0DXC7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="10">GAT</shortName>
                <ecNumber evidence="10">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Ornithine acetyltransferase</fullName>
                <shortName evidence="10">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="10">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">N-acetylglutamate synthase</fullName>
                <shortName evidence="10">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_13289</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="10"/>
    <dbReference type="EC" id="2.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429186.1">
        <property type="nucleotide sequence ID" value="XM_023575958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXC7"/>
    <dbReference type="STRING" id="1279085.S0DXC7"/>
    <dbReference type="GeneID" id="35406743"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13289"/>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_1"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
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        <property type="term" value="C:mitochondrial matrix"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023566488" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023566490" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="10">
        <location>
            <begin position="221"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="10">
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            <begin position="220"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT67105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="452" mass="47939" checksum="87689366ED236DCA" modified="2013-09-18" version="1">MMKKFARAYSSASATLGSNPVPPSKIQYIPTSGKYPKGFIASGVLAGVKPGNTSKPDIALVTSDRPCAAAGVFTKNKFQAAPVTYSRKLLQQKKNAGLRSVVVNSGNANAVTGTGGLEDATSMARTTDQRVGDEDSTIVMSTGVIGQRLPIQKILDKIPTAVSKAGGSHEHWLDCAKAICTTDTFPKLMSRSFELPSSPGVEYRIAGMTKGAGMIAPNMATLLTILATDAPISPAVMPNVLRHAVDRSFNSITIDGDTSTNDTVALLANGAAGGKEVTSEQSPDYQAFQELLTEFSIDLAKYVVRDGEGATKFVTIRVVDSASEEAAREIGRSIAKSPLVKTALYGKDANWGRVLCATGYALISPPGQPVNDVPEITPERTNVSFVPTDGSAELKLLVDGEPEQVDEKRASEILAMEDLEIVVRLGTGDKSAVHYTCDFSHDYVTINGDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY14</accession>
    <name>S0DY14_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_13655</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCT67444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_023576365.1"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:mRNA processing"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:RNA splicing"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
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        <property type="entry name" value="R3H_dom"/>
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        <property type="entry name" value="R3H_dom_sf"/>
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        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
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        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="418"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="544"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="249"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT67444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="587" mass="65284" checksum="D8DFE935AD1A069C" modified="2013-09-18" version="1">MDNPDAKSGFTLADEARQTSQHDHSTWGNSSLRLRPVTFVSAGPTEPLKFLDAIVDPGDKKDNQADEQSFEESTDEVEFIGPDDLEEAIQAETAPEESIPQEVPFFFDLTGDQVQKKKDLPPVEIPDRPSSSSSTSSEEVLLFKGRGAQRNVQSVPDIDMMQMQTEIRVVEQAIITEPAHSQQTPAPELQTEPIRSKYLTKIEKKQKKREKRNAKTKLDDEEDAILADYIANLKENTEVDDYFKELLEGGRHSDDSGVSESANAAGDDTDDHTDDAEATNGDEVPSEIDDETLARLIAGQHLGQDLGMEDVHFGDSSSDSDSDSDDTGKRTKQHQEFGNDFDLMDWDRPSLRRRKGKGARAQISFNMSDSELEASLQASWKSDRLKKSERKKQREEMRALGMLGKKDPDDLRVKYPDGMNMDQVADELQTFLMGSDEQLNFPPMDNNARKMIHELASKFKLKSKSIGKGDQRRPTLHRTKRTPPYVPATFDQALKRVNRKYLPRSDKKGKKGNRLPPARGGTSVAAATYQDGEVVGASAPELGIENRGRAMLEKMGWSMGTALGASNNKGIMQPVTHTMKRSKAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYF1</accession>
    <name>S0DYF1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to tetracycline resistance protein (Probable transport protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_14397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429655.1">
        <property type="nucleotide sequence ID" value="XM_023576751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYF1"/>
    <dbReference type="GeneID" id="35407848"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14397"/>
    <dbReference type="HOGENOM" id="CLU_001265_54_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="478" mass="51987" checksum="137B72A517B390CB" modified="2013-09-18" version="1">MNPTTPLLSPDRTSTSYSNLTEFPPLVLRNDKKRRGTKKSLRIKMQIPLLCYARFMVTMTYFSIFPYVALVIQHNSGSRATDIGTCVGLFEVLFLAAQALTSMFWVIMANRFGNKSILVYILLGTAISSVIFGFTSSVWQMALCRCFMGLVSGGDVVIRVMIGKRCMTETEATRGFSLSSLAGNVGMASGLLMGHALVSHFRQYSTIFKPVSFLGQHPFCLPGITIGVMSVTCAIVAALFVEDANEAGEDTHSTSFLPPTRTSLRELLRSPGASNTVSSFINISLLGSAFTAVATLALYTDIGQGGLELPGHEITLYMICQVAFAACWLFLIYPALYRQFGTQNIISLSPIIFPFFFVSLSIMNAFVRSGSEPGFYLFRVVLGVMTIMGPAVHMAVTAVYVGLQEVSPCPQELGLLNGVAEAASCLLQATVLSLGILIYAFCNDPSVTAGYLNWVVLLLVGLSFFVLIFPTWTRLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYG7</accession>
    <name>S0DYG7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable bifunctional D12/D15 fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429680.1">
        <property type="nucleotide sequence ID" value="XM_023576480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYG7"/>
    <dbReference type="STRING" id="1279085.S0DYG7"/>
    <dbReference type="GeneID" id="35407916"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14535"/>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="402" mass="45873" checksum="79DB65F7CAD6631B" modified="2013-09-18" version="1">MATRQRTATTVVVEDLPKVTLEAKSEPQFPDIKTIKDAIPAHCFQPSLVTSFYYVFRDFAMVSALVWAALTYIPSIPDQTLRVAAWMVYGFVQGLFCTGVWILGHECGHGAFSLHGKVNNVTGWFLHSFLLVPYFSWKYSHHRHHRFTGHMDLDMAFVPKTEPKPSKSLMIAGIDVAELVEDTPAAQMVKLIFHQLFGWQAYLFFNASSGKGSKQWEPKTGLSKWFRVSHFEPTSAVFRPNEAIFILISDIGLALMGTALYFASKQVGVSTILFLYLVPYLWVHHWLVAITYLHHHHTELPHYTAEGWTYVKGALATVDREFGFIGKHLFHGIIEKHVVHHLFPKIPFYKADEATEAIKPVIGDHYCHDDRSFLGQLWTIFGTLKYVEHDPARPGAMRWNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ76</accession>
    <name>S0DZ76_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429932.1">
        <property type="nucleotide sequence ID" value="XM_023576545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ76"/>
    <dbReference type="GeneID" id="35407975"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14594"/>
    <dbReference type="HOGENOM" id="CLU_581466_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="470" mass="53638" checksum="D186B6927A081EC6" modified="2013-09-18" version="1">MSVDSDDDSGWLENVSLITQHHKVFIVPRVEQEEVNDFNVDFEENTRIARKDVNMMTVYDVGGQDPLVFPFHADCYELLGKVVKPQKIDNAPLFRVLTFHLPRLLYGPPNVLDFNYGKLKRYQSDEWDTALGMEYAVASPISIENVTSVIEGVLRKANKSNVPDNRSTYNIPTGPPPGRERSQNGDISDTEWENKFATEFAWIREFLPYKEEIERRHIDRFLFCKAIFDLGGGRGFNTPDYRDTLRALHNRRRLWELCSKIVQEYLPLSQQRSAQEPGANSSPEAARSRTTSSVPTSTPSTIDFFRKPIKGSIPWPCEPHELRNKSPIGASSMETLTLVARGSDLNNAVRFGVDANMQRFEIHFEENGRKWSHCIGPRSTAMQYLYFDKSSVVPDRITSCYVTMKQNVPSGLRFISQSQTITAGKPEEDETMYPPQTNWGGWMTGIFCQWLDRDSPDAKLASFGVYFADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZE0</accession>
    <name>S0DZE0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_02826</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427929.1">
        <property type="nucleotide sequence ID" value="XM_023574603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZE0"/>
    <dbReference type="GeneID" id="35396308"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02826"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF84">
        <property type="entry name" value="VACUOLAR MEMBRANE AMINO ACID UPTAKE TRANSPORTER FNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT65848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="541" mass="57473" checksum="658535CEA45DA74A" modified="2013-09-18" version="1">MNSSLSSGNPSEGSPLLEDRYHDDAPRNIENEQTSDDDTPKALYSDKKLHLVVAAVGIGVYLAAADQLLTVATYAKIGNELNALNNTSWIATAYFLTLTSSQPLYGKLSDIFGRKPCLLFAYIVFSLGCLGCGLAQDMAQLCAARAVAGIGGGGMNSVVAILLSDLVPLKDRGVWQGKISILFFAGTATGAPLGGILADSVGWRWSFLGQVPLCFLAFVAVYIVLDVPPVEHDHWLTKVRKVDFLGAFTLVAAVVALLLGLDSGSNLGWSHIMTFVALSSTPVLFGLFLLIEINVASHPFAPGHIIFDRSLFACYGVGFFSGAGQTSTIFFLPLVFQAVQGLGAAQSGSLLVPGMVAGVAGSLLGGWMIKRTEKFYAITLSAYALVLVSVIPMGMFVWLRSAAGETIGLTIMSFGAGCAFVTTLIGLLANAAAEDTAVVVACSYLFRSLGASIGISTGSAVLQQVLRIQLAARLPDGEEARKIEEKVRQSLDYIKELPPHLADQVRSSYQIAGISSLALISIYLAVSFLLAFWIKEKPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZQ8</accession>
    <name>S0DZQ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428978.1">
        <property type="nucleotide sequence ID" value="XM_023575707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZQ8"/>
    <dbReference type="STRING" id="1279085.S0DZQ8"/>
    <dbReference type="GeneID" id="35406521"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13065"/>
    <dbReference type="HOGENOM" id="CLU_621182_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="436" mass="49178" checksum="299BBF65059CF5AB" modified="2013-09-18" version="1">MPFNNYQDYVRGYPYAGGRDVVRPHIGRGLGRGQPQGFRNATIGPSYGQQQWQYQQPAFYPQGYGRAAHNYYQSNDYYQLASQQLPLTAVTLHSQPLYAEPLSAAVKNAIRLSLNAKYPQHQGQPVIQNHSESHSQEVHPEQAPRGTKRKNNTEHGEQANMTHIAEPAVFGDHHGSMHEKNAINQGVDYGLLKAKGHATFANREAAIQAIEGMFQRGEPIILSWNSGISTAPPKTAPKMPSCTTKRQRIVSGRDSLALERADPDIYFKLRNTNTHLKAANNPTICGNCQDRGHTVAMCHQVHETGFIRGCAICNSSQHNTWNCPEFPKNDTHEMINIMVFSRANMPPLAGKFWYPMLFDYMQANPDMFVPGLPWSLQHSKRFYISRDIQDPFLLVQHRRETEKLGGVDPRTSSWENTKAYYGTDKHQKLPETAGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZY2</accession>
    <name>S0DZY2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to synaptic vesicle transporter SV2 (Major facilitator superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_06711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT67960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430040.1">
        <property type="nucleotide sequence ID" value="XM_023576880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZY2"/>
    <dbReference type="GeneID" id="35400188"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06711"/>
    <dbReference type="HOGENOM" id="CLU_001265_52_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="81"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT67960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="554" mass="61058" checksum="8681204069A9EB9B" modified="2013-09-18" version="1">MSDKSTTDGPVTMPQPSDKLSDRERYADLRTSGDRHGESLSFQMGTEDEQIFSLRDIDPVLDAKMRLINKTMDEIGWTNMHLKLFFLNGFGYAADSLILALQAVTAGQAALEFRPAFSYGLNVAVYTGMLVGVLFWGLGADVIGRRYAFNISLFLSSVFAIAAGASPNWIVLATFVGLAAFGAGGNLVLDTTVFLEFLPGNKQWLVTLMACWWGLAYVIVAAFCWPIYSNPKYTCADADTCTKGNNMGWRYVWYGNGALVFVCSILRVTVIRLKETPKYLLAKGDDVAVVAIYQDIAKKYQRTCSLTIDALESMGAINSTYGKSRYSLSELWAHFHGLFVTRKLAISTILIWISWLLIGLAYPLFYVFLPDYLASRGAKTGESGPYYQWRNYMLSSVTGIFGPVAAAFMCNTKLLGRKYTMAIGALITMAFFFAYTAVKTPAQNVALSCVIAFTLNIYYGTLYAYTPEVLPSAHRATGNGIAVAGNRIMGLVSSFVAAYGNTATSVPIYVCAVLYIVMVSYTPGDIPEEWRLIDMYQAIIAVILPFEPYGKRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZZ9</accession>
    <name>S0DZZ9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430191.1">
        <property type="nucleotide sequence ID" value="XM_023577065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZZ9"/>
    <dbReference type="GeneID" id="35400352"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06875"/>
    <dbReference type="HOGENOM" id="CLU_1896386_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484683" evidence="1">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="134" mass="13700" checksum="64CFDFC53435E4BB" modified="2013-09-18" version="1">MKTTAMFMIAAFASSALSLDVKDASTPGGGTPGSPACGRQCLITISPVDGASTQRSDGFPGSCKEYATGQLKGTNRAIDGGRLNINGVGGNLVIDFVKNGRDRRASFTNCKEAVFTGAQCSLKQGGCDKQAESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E050</accession>
    <name>S0E050_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MUC1-Extracellular alpha-1,4-glucan glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_06769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023576946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E050"/>
    <dbReference type="STRING" id="1279085.S0E050"/>
    <dbReference type="GeneID" id="35400246"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06769"/>
    <dbReference type="HOGENOM" id="CLU_006489_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495384" description="MUC1-Extracellular alpha-1,4-glucan glucosidase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="135"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="588"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT68015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1050" mass="109109" checksum="FC892F911CEB0B77" modified="2013-09-18" version="1">MRSKATLCALWASLLSFCLAASCDQLSNPYQGPDDTQFEITCNAYSLGGNQIGPTIEVTDLSSCIELCATTSGCKAALFDRSQYLCYTLDESDGPASNSLYDMAVLLSSAASTTAITSTALPTTTTAAIPAPTPCNQLDNPSYIDDVEFTIFCGKQATGGSQVDYSNQMRSLTECMTFCADTLACRAVTFDNWFNDCYLFDGFNGFMSDSNKDMAIASRPVASSTTEAPTEVSTTTSIAAASTTAPSGPLSCEQMAGSVYTGPNENKFTISCDTSSTGESIYRRDEEDSMQGCVDRCDRENRCIAVNFLPSPYYECDLIESFTGTKSSPSTNFASKILSSASTSASSETLSTLYTSSSASISSGFPETTSSSLPSTLTSESMTASTLESLSFTTTSAVTSEAAASLSTTLSASTSLSLSSGAPSGTTSESALQSTLASTSATTSLAVISSSTELSASALPNPHSSLSSESVSESTSDGRLDSTSASLGPTTVATSAVSLNTDSTSIEISTAETLTTKTSSAETSNLETSILQTSDTTAPATTIQSTVTESSLSDTGRISTEIQSTSDASASPSTSSTPTASNIPALGEYAFTGCLKSLESYPSFKEVATDPKMTTGKCVDLASGSKYIGVYQETCYKADLLDDTEFIKDASCNLPCPGDRTIFCGGILRSDQKLRHRAIAPNRLLTLYSKAASSSDTTSSASATASASSLQTTGAQTDKTTSGSTSTSRYSQTDSSYSLSSFTTRSASSKTLSASHSIIEETTSETHLPTSIPTPTAIHTAYSTLTIGHASTKTQFAETVTTVTYTTINPSNPASLITTCVPITLLYSPCGCKHQVYPTVDMTTVACTNGGDVATLTVPKAAYETGSAIYTHPIVQYPSGWLGGHQTDAGSNSYPAVQPTRGSQPNSKNGQPESHTVAAGLKDSHPSYKTHQPATPTSAVGSNGDDQTEQGYPQPSVAAQGSPESNGNTLMSPSQPSSPKSLITETSIIPTPQLDTSALPSQSSPPRQSHIPSKSKGAPYASPAVVSEAHRHDLASWITMTAIVGMILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0D9</accession>
    <name>S0E0D9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to bifunctional 4-hydroxyphenylacetate degradation enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430165.1">
        <property type="nucleotide sequence ID" value="XM_023577033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0D9"/>
    <dbReference type="STRING" id="1279085.S0E0D9"/>
    <dbReference type="GeneID" id="35400323"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06846"/>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="78"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="274" mass="29779" checksum="8EB37B6E13A435A4" modified="2013-09-18" version="1">MAPNWSHLVRFLAEEDGQVHLGQIDHEAWPDVGISLEKGEKIQAKLIQGCVFDGVVTERLLTVKELLAPLAMDQVPIIRCMGLNYRDHAKEANMPIPDVPVLFIKPRTALNGPYPAKVNVPKIAQDGTSDYEAELSFVISKTGRDIPRDKALDYVLGYTASNDISARAQQFKNSQWCFSKGLDGSCPIGPLLVSPSAVGDPHSLGIKATLNGETVQDSNTRQGTTLERGTIIMTGTGPGIGAMRSPPLSLKDGDDVRVYVDGIGTLINKVWYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E152</accession>
    <name>S0E152_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to PCL7 Cyclin like protein interacting with Pho85p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428499.1">
        <property type="nucleotide sequence ID" value="XM_023575296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E152"/>
    <dbReference type="STRING" id="1279085.S0E152"/>
    <dbReference type="GeneID" id="35396929"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03447"/>
    <dbReference type="HOGENOM" id="CLU_052076_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF32">
        <property type="entry name" value="PROTEIN KINASE COMPLEX COMPONENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="339" mass="37118" checksum="893EF492612A95C0" modified="2013-09-18" version="1">MSYQAAVTTEAQAGTIPLRHPDTTTDRPPPPPPVPSSDPHLIADDPSAPKASADHGLFEMSPAEALALLSAGVELLVRITGDVPPTPPPKSPTVPHMSGMQAEKENIVRSYSDKNLAKLRKQAELEAKRLAAKDKPEPVHDNQPESGDIDGVRLKPHPGLMSPPPQSEPYVVVGADSQPVNLQHSAITRKFYSKNEPPITINQYLQRLHQFCPMSTAVYLATSLYIHRLAVEERAIPVTRRNAHRLVLAGLRVAMKALEDLSYPHAKMAKVGGVSEAELARLEISFCFLVGFELVVGESRLRKHYERLRDRTSHHGFDNADVPILNLKPRPRGGVQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1Q7</accession>
    <name>S0E1Q7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C6 zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428674.1">
        <property type="nucleotide sequence ID" value="XM_023575503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1Q7"/>
    <dbReference type="STRING" id="1279085.S0E1Q7"/>
    <dbReference type="GeneID" id="35397116"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03634"/>
    <dbReference type="HOGENOM" id="CLU_011409_12_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="60605" checksum="86225FABAEC5B416" modified="2013-09-18" version="1">MTQQTLIIRERPPIIRALNNNLGEELSFHAFDYYRGHVSHQVGDTVDSDFWGNLVLRLAPTDPAIRHAISAISLMYAEKTKDTRDPFPNYRPAIVEYNKAISAVRSWPLATESRVKPLLVCLLFVCIEFMLGHEHQNAAKMHILQGRRLLANIQDRKTPETDIIRQYLAPIYLRLAYVGNDRVNFPRHLLQMTTAPLKFASLADARCVLYYLVDIGFTLIYDVKSYRSNGVSESPNTEGEALQSRYKHIAHDLANWRHAFEAYLAFSDLDRPDTRTAKLLTQRHCLMLVFLDSMVSGSDYVCDRNSLSEFSIAADCATFTVKYDNEIMQGPSFTFESEVVGPVYWIAAKCRQPAIRRRALELLYEREKANRVESLTIVKHTIAMAKRVIEIEEEGLEIPKGTRPIQDYPNKYEVLLREESSEWAEGFLTDQKEQWPVLWDLGSHCSDIPTKLTGIAAAREQKELSEGLAKGWPRERLVWPYGITRERRVLSVVVKKHTANDLWLEYVREPLTAGGDYRVMKEHIQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2C0</accession>
    <name>S0E2C0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431016.1">
        <property type="nucleotide sequence ID" value="XM_023578052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2C0"/>
    <dbReference type="GeneID" id="35401240"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07763"/>
    <dbReference type="HOGENOM" id="CLU_547561_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="501" mass="55064" checksum="EDD316D96F0CE195" modified="2013-09-18" version="1">MPSTRPPNAQSPIVDVDSALDNIDTIRIPEPHGTYLQTRGARAARRIYKAMGVWPWDIVPEAPPKMWAINLLEDLALVADHVARNPGDTLQDLQSELRKSLARDRKPSYAGKLMAQDVHAAKKRFVRTMPQSPDAQDDTGDDAGTAERRSGRRRRTANYSAPDSPIDPSRSRRDTSSEESEEHMASSITVASEFPPSPPVPRNIKHLKRPATTIPTPIEKRVRHSSPEGSRLSAAQSLMMFSSPMATFQMATSFGPNATANATRSLEPNNLQEALKPATNVFVAAIDAHVRTIRSSLAIAQQEIFPHRSRSQEAMSKLRAAQLGVQAIQDDIAESQDRLRRLVEESVAEDALAPQLHALQENNMSLPPEIAQAIRSYESRRAAKSEEIKTQESAINAKRDELKRAAEELDIAETNSSGIEADIRDLQAAVTRGTEAARFANMFSVMVQLGPEGLANIEQIYPEIGSLLESLLASRNSPSQQNHNNNHHVHNAVDGDEANGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2X1</accession>
    <name>S0E2X1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT67987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430067.1">
        <property type="nucleotide sequence ID" value="XM_023576911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2X1"/>
    <dbReference type="STRING" id="1279085.S0E2X1"/>
    <dbReference type="GeneID" id="35400215"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06738"/>
    <dbReference type="HOGENOM" id="CLU_839590_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="38262" checksum="E449CC0B96631A39" modified="2013-09-18" version="1">MSKEISPGGYHWLNDTINSLDPETDYELMWRLMSCYRSNDFMNNMIYALTFPNFIITTHGCETVWRSDGGKVVKRGAQRVEDTENYNMTWWHYGPSDKRCRDAVEHINNLHASLARRYPGNFSYNEDFLYVTTFSAVLMHRLRLRLGLSGFTEKEKIAAHHFWRDMTPLFIREDGNSVCGYPEDFEGCIQFCEDYENEKREFDVKMQYIGLAIFNQFAFRYFPYGFRWLGVSIVKALTLPTTIKAMRLEPVNPVFQWLIVLFVGTAMSLAETLLPDPRESFWKKIETLDVEKAKARKEDIRGSDQAYCQYIRSEWSGPGCPFAMKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2Y0</accession>
    <name>S0E2Y0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT67997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430077.1">
        <property type="nucleotide sequence ID" value="XM_023576923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2Y0"/>
    <dbReference type="STRING" id="1279085.S0E2Y0"/>
    <dbReference type="GeneID" id="35400225"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06748"/>
    <dbReference type="HOGENOM" id="CLU_690767_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="474" mass="51596" checksum="8401DC17ABF332B7" modified="2013-09-18" version="1">MPPYNFPSVRASCDRCRFHKLKCIVNAEDKSVQQKCARCVRAKVECVYSQRARPKRQKNLESEGSSGEGEMGPLTPPTGSGEDASFDNLDSSYTGSPDIWAMLNTSDFGVRLDESTLTFGSFAQTPPGVASASASGLHVGSMLDVVPNQILGNGLVTEPTTPKLEQNTVLDTSARITPFMHDCTQSQANGSIDIDGASPITRLSNLMADIYRTLAILTGTSHASKYPNFNFCEYPIGTVLHLARTLVEIIPQVTSSFHTASAFTQDVNGVSRRDSISSISPFNSYSYYADLQSITPPSSTASHSLRDSMDAPTKMLAMSCYSSLRRLYCLVLTHFETYLRMTLPAFTSELLSQNAAGVKTLQLGELPLTDEVCSRIGTAVKLMLDALRSAEDMLGLSDYASTTRRCRKADPCGCPFSAGSTERGQDVTPLAYEELSEVFKDSAMMGYEGAHMDNLASKVESVKTMLKDRIDLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E302</accession>
    <name>S0E302_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to prenylcysteine lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_13244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429144.1">
        <property type="nucleotide sequence ID" value="XM_023575906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E302"/>
    <dbReference type="STRING" id="1279085.S0E302"/>
    <dbReference type="GeneID" id="35406698"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13244"/>
    <dbReference type="HOGENOM" id="CLU_021176_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485237" evidence="9">
        <location>
            <begin position="23"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="10">
        <location>
            <begin position="134"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT67063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="548" mass="61074" checksum="0BD6DFA6CBC18C08" modified="2013-09-18" version="1">MYLTSTLPLALLGAFASVLCRAEDVHNVAIIGAGAAGSSAAFHLWQYAIEEDIAINITIFEKTDRIGGRTLTVPAYDDPSMPIELGASIFVGANHILANASERYHLPVSEPHRLEKDDMTVIWDGYEFVFQTTERSWAWWDLAKMFWRYGLAPYRSKQIVDAMVKHFLKLYEAPYFPFKSLTRRAEQLGWNDITSITGEQMLKRNEIDPRFAREILQVGTRVNYASNLAHIHGLETLVSLATDNAMSVDSGNWRIFEHMVIESGASISRNTTVASIEKVQKKTRSSSPVYVITTKDASSKDGTSKEYGVEFDNVIIANPWQFSKIKAGEGVLDRKIDEIPYTKLHVTLFASPLELSPEFFGLKAGSKAPATVYTTLGEDEEPRKGAEGVGRTGFYSVSTLKYLANPKTYQKERVYKIFSPTPITADFLTRLLGTDIPDSVISGKLQDDANTSNPISWYHSHWFNSYPIELPRVTFEDPVIGEGVYYTSGIESFVSCMETSALMGKNVARLAVDKFAGISRPEPPTEWEGYEADDEEEGGIRAQAGSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3D6</accession>
    <name>S0E3D6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase MRP protein 1 RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431396.1">
        <property type="nucleotide sequence ID" value="XM_023578193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3D6"/>
    <dbReference type="STRING" id="1279085.S0E3D6"/>
    <dbReference type="GeneID" id="35401367"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07890"/>
    <dbReference type="HOGENOM" id="CLU_031977_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047204">
        <property type="entry name" value="RMP1_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20945">
        <property type="entry name" value="RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="2">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="270" mass="29774" checksum="A0558485AF59EF12" modified="2013-09-18" version="1">MTTPPDAALLATTSDSLAPLIPILNGFAHRHKNQHSSSHWWSSFSVLRRAVRNLVDDLNSRPRKVKSGNVKRDVHPALARAKWMMRHVVPGAFVTFSQLAADNQHAPLGLLLLSVLARTNTILSQLVPDHDHNPQISTSTKTMLSEPSKLKTSDSRADDAPDTGVDMGVAISRDELLSTQSTRRKTKPVPRVDSHSKDLKLKEYETKTTHTDTKNIPSKSDTVDKPRKKTKNSDELSSLFGSLSSKNGTADKPKKKKKKGDAFSSLFDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4B0</accession>
    <name>S0E4B0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_07304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430597.1">
        <property type="nucleotide sequence ID" value="XM_023577541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4B0"/>
    <dbReference type="STRING" id="1279085.S0E4B0"/>
    <dbReference type="GeneID" id="35400781"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07304"/>
    <dbReference type="HOGENOM" id="CLU_008378_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="119"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT68517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="674" mass="73948" checksum="572D848EF9DCFEAA" modified="2013-09-18" version="1">MATPTAAKHASQQGRTPSQLAAATPPVSTPFSNPAHVVFSPRGARSSPQQFKKSPAASTLMAHASSAPLNFDSPSTAAAMGALGIPSGLDMGLDNVGVGGLGSLGALASEDDKLKRLETIIATLDQKKGLVGEAGLERLAQRIGLDCLSEDHTAPDGRKQRTLVIAGSAIQLEITLHNNIVENISLAFPESARSVTDHVTRASEILLRDLQLLPNQSPLTKTLDKFAANLERLAVLDKLSIIPGLDCHEALAGIYVSLERLHKWDVGRLRDEPGMGGKSDSELSTMAMCTRHGYPVMHSKDRVGLALQYWKALRLVQPTNTKLASFASSHEPVWSLLIGCASTGGMGHMPVRVSEDWISKGVVKAEPSMDPKRPNLDWQEPDNVVLPHSEENKDASMEMLQPDLSTARVPQVMFVATFDPPVILPQNDWLRLHSYANVNANPLFGYSPTFDSLFFPIPPGSAQDPSELRAISRSRDVRIYNKDQEAIVKPHQNTLYIYKQIYSQVVTEIPFSHPQQLIEMLPLLRQYAFVATLLENSFGSQTNEVERLPKQGNNASPVPKSNLTTRDELAEFMNSASVTDDHVSAAPEVKLDVTLWVHPIPHLQVVFPFRDSTANITLKVLEDGIVEVVEENVIPRGDDNRMKGKELTRADLGKLLEYMEDLCKWAEWIRTRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4E5</accession>
    <name>S0E4E5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to regulatory protein alcR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431691.1">
        <property type="nucleotide sequence ID" value="XM_023578730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4E5"/>
    <dbReference type="STRING" id="1279085.S0E4E5"/>
    <dbReference type="GeneID" id="35398990"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05511"/>
    <dbReference type="HOGENOM" id="CLU_006237_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="833" mass="94854" checksum="590B911159E0C551" modified="2013-09-18" version="1">MKRTQYACDQCRKSKRGCDAPPLEIPGNMDPLRDGKMIVGEKPPLAQSSPCSYCTKTHKKCTMNWAWTQIQISYALAAAARGEPGIECIVPSRRDSTSTRRESTSTENTRDTPNSIVPDDNSFDVQSAAQSFVSQSLPPVPVFSEIDTSLDVPSFLDNSLDALPFDFVPEQTEPVDANFYGIQFKDLTAPEEPLSEPWDFCKDSTISPELQFDVASMSQFPTVSPTEPAQSLIAVSPNNDKDWRRPKRRRVSNTWSDTQSSSLSSFTMDQSMMTRSNNLMISTNLLQIYHDVLEHNLSCWLNEVTCPFGRQQKTVSQPGNLAEWGSSWTNRVLRRTMNLDRVAQSTQLVHLSRQQDSATAKALHLCIMAFATQWAQSSRRHRERYPSLDDIAEENPLNEYMDDFKEEFDRHLQRNIWDQARRALDDVADVESYRVVCAEMIFGLTQKPLDPEDTEHSDVDTSGCFEDVYDMQSVADEIASIIENDGPPIFMERAARKMHTLKYRFDAERKGLTKGRKRANLVASMSSEDAGTVSLLYWLTVMFDTVSSTMSERPLVVVDANSQHDDARGDTDWNVPLFIQDSLEKPRQNVHWPCSYEEAAEAVTRSAPVKVLMFRHVAYLQNLLRQGESGEKVEGFIERSARVYRYWNTTYGTFFRELLQNYNSIPGRIQSWFICICAHWNLGVLLLADLIHHIDEHALGLPAPSQSRSNCKWVMRIRERSARELSDLARVTAPDNRTPIVPTLSEFHHAINQCMILTEPWTVILIRAFSKAANYWMAEVNELLQVDRAGEELEERLGRGEECIRILWILGKKSDIARRCAETLSRAKTRLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4L0</accession>
    <name>S0E4L0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to nonribosomal peptide synthetase MxcG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_14588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429714.1">
        <property type="nucleotide sequence ID" value="XM_023576538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4L0"/>
    <dbReference type="STRING" id="1279085.S0E4L0"/>
    <dbReference type="GeneID" id="35407969"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14588"/>
    <dbReference type="HOGENOM" id="CLU_002220_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="68"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="7">
        <location>
            <begin position="684"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1011"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117056" checksum="F029C5916C2848CE" modified="2013-09-18" version="1">MSEPVEHANIVETMTIRHDSNAVEARKPAVQPSQAKLFTLDEMIKRRAVELGDTILMGAPETGVDDFKEHSAVDIDRYADAAVARLQSLGLEPVDPTLEKAPVVGMLGQSGIHVVIQIIALNRLGYSSFLISTRLASPAITQLLTLADCNVILTTPPFHPVLKEVQQNRQLEVLPLLQSADIFHHNAPRFVRDYSPEAESRKVAVIIHSSGSTGLPKPIYLTNSSCIGAFAVHMNMRAFLTSPFFHSHGFYEVFRSIYSGKPIYFTNYGLPLTRETVMAQLKATKPEIFHCVPYVIKLLAESEEGIQMLADMKLVLYAGSGCPDDLGDRLVERGVNLCGNYGATETGRLATSARPEGDKAWNYIRVLPPAEPYTIFDEVAPGLFECVALDGLPSKSTTNSDSPPGSFRTRDLFTQHPTRPNLWKFACRLDDRFTLINGEKVLPIPIEGRIRQEEIVKEAIVFGDGRTYPGILIVKADRVANMPDDEFLDAIWPSVEDANSRAESFSRIPKELVVIVPADSAYPRTDKGTFIRVPTYRQFEKEIEAAYNRYEGQGDEAGSLTLEGLELEDYLLQQLKSKCGANLESSEADFFASGVDSLQCIQMWSLIKREIDLGGRQSELGQNVLYETGNVKLLARQLERLRSGESDETQDQLKIMEGLIEKYSSFERHVPGSAPQPEKELVLLTGVTGALGAHALAQLTARPNVGAVWALVRAASDTAATERLYSSLQARGLSLDEEQRSKVLALPCDLSRPDLGLSESHISELRTKLTTIIHSAWAVNFNISVQSFEDQHIKAVHNLIQLSLSVQTPKPARFFFCSSVSSAGGSPRPGKVLEAQVPSPAHAQHTGYARSKYVAEHITGNACKSAGAVARVLRLGQLVGDTKVGEWNTTEGIPLMIQTAVTLGALPALKEEMTWLPVDLAASTILDLASLGASSPTDRSSDHDLVYHILNPVRFHWANDMLPSMTKAGFKFETLPTDQWMDRLRNSERDPAKNPPIKLLDWFEGKYGNKAASSAEKGPLDYLTDKSREDSETLRNVPDVTDVEYVKMVLGRLQTRWAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4T0</accession>
    <name>S0E4T0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431750.1">
        <property type="nucleotide sequence ID" value="XM_023578800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4T0"/>
    <dbReference type="GeneID" id="35399053"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05574"/>
    <dbReference type="HOGENOM" id="CLU_746055_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="311" mass="34820" checksum="B4125011921A5FEF" modified="2013-09-18" version="1">MSRHSKRSTRKVGFLDALGQWTMGPSLNRSRSSRCRRHPRSTSATREARLANAPKDLNLTARQWRQYADVPPEPQDECDCSDCGEDYSDDEQKSLVSAEPVQRICSKWSHSEGSAFTREPPAVHRDSGLNRILGRVEAEMAEEQRLRHRVSYDADNDALFANIPRRDQRSPGEIIVHRHRLGDGEDFLAVETFGHGDSSHRDADVQSVRSSQFFLNPREAPPVPQDAWPSSLQHVPKGTKTRIQSWRDCVKNGPEPEPSVFGGSNAPTVWPGSGETVVPDDSLTEVVVRNSRGSLQRELKSGGSRRHSGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4W5</accession>
    <name>S0E4W5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable alpha-N-arabinofuranosidase / alpha-L-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431795.1">
        <property type="nucleotide sequence ID" value="XM_023578852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4W5"/>
    <dbReference type="STRING" id="1279085.S0E4W5"/>
    <dbReference type="GeneID" id="35399099"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05620"/>
    <dbReference type="HOGENOM" id="CLU_009397_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18619">
        <property type="entry name" value="GH43_CoXyl43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="327" mass="36839" checksum="2996DDB7D4299350" modified="2013-09-18" version="1">MAPLITNVYSADPSAHVFNGKIYVYPSHDRETDIKFNDNGDQYDMADYHVFSTESLDPPAEVVDHGVVLKTEDIPWVSKQLWAPDAAEKNGKFYLYFPARDKQGIFRIGVAVGDKPEGPFTPDPEPIKGSYSIDPASFVDEDGQAYLYFGGLWGGQLQCYQKGNDIFDPEWQGPKEVSGEGVPAQGPRVAKLTEDMHQFADEVKEIQILDPETGKPILGDDHDRRFFEAAWMHKRNGKYYFSYSTGDTHFLCFATGDSPYGPFTYGGRILEPVLGWTTHHSIVEFKGKTYLFYHDCELSKGVDHLRSVKAKEIFYDDDGKIITTTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5J3</accession>
    <name>S0E5J3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_05900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432049.1">
        <property type="nucleotide sequence ID" value="XM_023579164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5J3"/>
    <dbReference type="STRING" id="1279085.S0E5J3"/>
    <dbReference type="GeneID" id="35399378"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05900"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000014">
        <property type="entry name" value="aldehyde dehydrogenase 22A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="96"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT69970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="618" mass="66405" checksum="DCA7FBA7C3B8254F" modified="2013-09-18" version="1">MSESAMDNQEPLLLTAWRRCNEFAAEHNISQSTVSAVGTVAAIVVATLILRLTNAIATASIKAATGRPRKFTVPTPKIPEPYSTVDAPSVRVSGSSAVQCYAPATGQFLGQINPSTPAAIDRAVVAAAAAQKVWAETTFEERRAVLRSLLQHVLDNAEDIVKIACLDSGKTMVDAQLGEILVTAEKLKWTLDHGEAALRPSRRPTNFLMMYKRNTVHYEPLGVVAALVSWNYPFHNFIGPVISALFSGNGILVKVSEQTAWSSQYFTNIARGALIAHGHDPQLVQTVVCWPQTAGHLTSHPGISHITFIGSQSVAHHVAASAAKSLTPVVAELGGKDPFIILDSASRDLKRIAEVILRGTFQAAGQNCIGIERVIAPRAIHDKLVEMLAPRVNALRLGPEADVGAMISDASFDRLEELIAEAVAQGARLLAGGKRYNHPEYPTGHYFQPTFLADVTPDMRIAQNECFAPVLTLLRAKSSSPEDILAIANAPNFGLGASVHGSERDPNLQPIVKGLRAGMVAVNDFAVYYAVQLPFGGVGGSGYGRFAGEEGLRGLCNMKAICEDRFGWLGIRTGIPPPVQYPIKSQPDSWKFTHGVVELGYGAPLRKLKGLGNILRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5M9</accession>
    <name>S0E5M9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable isovaleryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_05997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432140.1">
        <property type="nucleotide sequence ID" value="XM_023579272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5M9"/>
    <dbReference type="STRING" id="1279085.S0E5M9"/>
    <dbReference type="GeneID" id="35399475"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05997"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000021">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase IvdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="47"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="164"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="271"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT70061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="427" mass="46225" checksum="3A36182D22AE1CC2" modified="2013-09-18" version="1">MATSVRTFRSLARPVVARRFRPAVTPPVIQSRLHSSKHPKGFEAPSNEELDELRERVQEFTRREITEEVAAKTDKTNAFPAEMWQKLGEAGFLGITADEDVGGLAMGYQAHIIVMEELSRASGSIGLSYAAHSQLCVNQLQLNGSPEQKQKYLPGLIAGTSVGALAMSESGAGSDVVSMRTTAKAVDGGYVLNGSKMWITNGPDADVIVVYAKTEPEKASKGITAFIVDTKSEGFSCARKLDKMGMRGSNTGELMFDGVFVPTENILGKVNGGVRVLMEGLDLERLVLSAGPLGIMQASLDVSLPFTHQRKQFGQPIAHNQLLQGKLADMYTKLQASRAYTYTTAKAVDENGLIRTQDCAGAILYAAERATECTLDCIQLLGGMGYVEEMPASRLLRDAKLYEIGAGTSEIRRMVIGRAFNKDYAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E711</accession>
    <name>S0E711_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432690.1">
        <property type="nucleotide sequence ID" value="XM_023579943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E711"/>
    <dbReference type="STRING" id="1279085.S0E711"/>
    <dbReference type="GeneID" id="35400077"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06600"/>
    <dbReference type="HOGENOM" id="CLU_042305_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="494" mass="51352" checksum="70EC6DC872886339" modified="2013-09-18" version="1">MRFSQIAPLALWVGKGAASGGQLFHDTFQLNELPNMVSLADAKMKDIVLPDSLSDFTEWIGGIAEPQAFGLQPRQRQCVDPGYYPCSSGLGCCPGGSTCISTGCCRGNAKECGSGRCYDPSSQICCSSGTACLKSQTCVSGGCCSRGETKCGSSGCYNPNTSVCCGGVGRNCPKGYDCMPGGGCCPSGQKRCGNSKCYNPRTTTCCTGPGTVWACPKSSDCCSTGYCANPSTQRCCKNGSCLKGTTCCEKECCRSGGYCGSDGYCKPCPAATKTVKSTDTVTTTKMKTVRVTTDIEPETGDAPEFTCVPMTATNDEGATLELDEGCTLHYEPPEATTTDDSAARLRRDAATAPAHVNRGNNILGRQVSCTPFTTYTRTEWETETETETGTKTVTVQGEDATFSCPEMEVTNDVGDTLALDAECVLSFTPAETTSSEEGASAQDQPTNVPAGTGESTTTVTATAGSGGSNGNSGTVERASLSLMLSFAGIALFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7K3</accession>
    <name>S0E7K3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to 2-haloalkanoic acid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432709.1">
        <property type="nucleotide sequence ID" value="XM_023579964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7K3"/>
    <dbReference type="STRING" id="1279085.S0E7K3"/>
    <dbReference type="GeneID" id="35400095"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06618"/>
    <dbReference type="HOGENOM" id="CLU_741959_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="373" mass="41250" checksum="AEBDC240B325A50E" modified="2013-09-18" version="1">MTAPNRNVVFDVVGTLVSYEHLYEAIKERLGDKLIPRGIQPTLLGICWLEMAEREYAYLSLHGHYVQFLKLFEALFYRCLHYAGVENPRSFAAAEDVAYLMNEFKELKLRDGAAECIQKLRDAGFTVWCFTTGDISRVGGYFSKAGVDMPAENLLSCDTNGVAKPCPEAYGPILNKLSTSESKPWFAAAHLWDVSGAKSAGFRTAYSMVLEGEYLYEIYGELNVVAETLPAMADKIIAAKPYEGFLEKHKKTLYLALGTHIILSNDHVAKLVQGLVAAMDQGPIDGVIWSISEAARRDIDTSHQFSATGCKGFTFALLLKGEHSSFLITTFAPQRAILDHDHTVIYLTHGGGSSADEGLYHGKLMLAMGFFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7S5</accession>
    <name>S0E7S5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_07290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430583.1">
        <property type="nucleotide sequence ID" value="XM_023577525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7S5"/>
    <dbReference type="STRING" id="1279085.S0E7S5"/>
    <dbReference type="GeneID" id="35400767"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07290"/>
    <dbReference type="HOGENOM" id="CLU_015024_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="544"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="677"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT68503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="767" mass="85931" checksum="EF393F06CC138622" modified="2013-09-18" version="1">MDSFSSSQEPRGSANVSPQAAQQQSSNLATLGQQRHQTTNPFWQNWAGDDPWNPLAFGAPNDGQTRSQLIGSANFQTSYQDYRSKPLLSECDTNPEDSAYGSRLTHSIGNPSAYGEDMDPDVQNLEPQNSDAQLVNRNLETLQLQCQPASNDAHLYQDQWVRPYPPASVATAPVGGERRWICGECQKRCRTRSELRKHELKHSLPWHCDVTGCSREKGFTSKNDLDRHKRTVHSDRTVSGRTFVCNIGNCAKKSKIWPRADNFRSHLQRIHAKTYSANDDLSEYVYRPVPSQDLEGVGGSAMAYLQAQEQLPGLAHPSTILSFRVPYGERRASQSQSGTNNPPRGPPSLSFDRDASSLATVREGDENFVHPDIIHGRSALPSNQWPVSASEEDAPGDDVTASEAEQPDDDALETMDGVQQGEGTTTDVSRNSGDSGSQQVDVRMVDADEAQRTPKAIPPHEKESKTPSDVSPESAYVDLLDKIPKELIASYLKKRFADLGEEASKLDTVNSKSQSHPHKCQDCDKAFPRLCELKKHQKRHSKPYGCTFADCKKTFGSKNDWKRHESIQHYQLETWICDCVKPDSAEPCGKVCYRRESFRNHLSKEHEITDTSKLEEKVEGCRKGRHCDAHFWCGFCQETVEIKETDNTWAKRCDHIDDHFSGRRVPQRDISEWIHEKDHRVVPSAPQVDESESSSGSSPCDPISPQSSVSTENSGEDRRGRKKDMYMWTCCNCAVENSFSNNTLCCECNQRSCKNCTWHAIPSTSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7Z6</accession>
    <name>S0E7Z6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to heterokaryon incompatibility protein het-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431992.1">
        <property type="nucleotide sequence ID" value="XM_023579093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7Z6"/>
    <dbReference type="STRING" id="1279085.S0E7Z6"/>
    <dbReference type="GeneID" id="35399315"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05836"/>
    <dbReference type="HOGENOM" id="CLU_004184_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="43"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="644" mass="72930" checksum="BB225C9BCE0F218E" modified="2013-09-18" version="1">MVYKYDSLLLHGQIRLLKIIPGTQNAVVSSHMSVINLDDNPTYKCLSYTWGEPGGDVTDESWSKPSQTILVDGFEIHIRQNLYNALIALCQSGILGPIWIDALCINQNDIEERNAQVSQMANIYKSAEEVIVWLGHEREYTQTAVACFQRLPITRQELLSDEHIVLRDQALASCSFTDSELLAMTRFFTDHAWFGRTWTLQEMWLARELTFMCGTIYASVDVILAGSSIAHDSYSSRSVTEDIQRTPAITWLMNFTYDLIAKLRKEVDETSPSPLGFEVDYHRARHATDPRDKVYGLLAISDTTTADDYMEPVVADYSKPVRQVFSIAAAHCLLNTTSWRGLSYIGDRSRYRIPDLPSWVPDYTQAIPWRLLQRRSEDTFKTATRQQVCIEYDTNSPYTIYSPYSYFDTITAVTTAYWEDIEGYSQMTEILNLALNPFPVKAFGEDNVLSVLARTLTADQAGIYDYDSYDFVGQFGEMIYGMLWLSISKNPDMVSELLKNPKASLSKALISIGIQDRGDLLSSLLHPYRQLCRTEEQIEPESKPTESQDQSLKARTSLIQLDWGSASHKRSLFRTKKGYLGLAPQTIKVGDEVGILQGAEVPHVFRRVSGSETSLSLVGDAYVYGIMHGELESEDLEFRMVQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E806</accession>
    <name>S0E806_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to ankyrin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_05846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT69922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023579103.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="35399324"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05846"/>
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        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin-SOCS_Box"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF125">
        <property type="entry name" value="PROTEIN FEM-1 HOMOLOG CG6966-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="143"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="645"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="712"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="745"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="778"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="811"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="844"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="965"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1728"/>
            <end position="2122"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
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            <begin position="52"/>
            <end position="62"/>
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            <begin position="85"/>
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            <end position="1550"/>
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        </location>
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            <end position="1604"/>
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        <location>
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        <location>
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    </feature>
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        <location>
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            <end position="1825"/>
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            <end position="1858"/>
        </location>
    </feature>
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        <location>
            <begin position="1904"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1920"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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            <begin position="1945"/>
            <end position="1970"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1982"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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            <begin position="2011"/>
            <end position="2033"/>
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    </feature>
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        <location>
            <begin position="2090"/>
            <end position="2106"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24883"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2122" mass="229959" checksum="9D9E55F2BD14D416" modified="2013-09-18" version="1">MSFTSPTEQFKAYQAFSPGSSSSKPPAQSFSSRVDFSDQSYDMPYFTGSDASVLNPQTNYGSTAPKPPVADVSRGFTPKQLADAPKTKSFDKKRLSSIPSTSKQAQPSQPLKAKIDYREFLESLEFPSTTESKISQGSGDLSSSQWLVQEALFIKWRTSNGLLWLRGSEGSGKSTLMKQALESCQGPSSIHLTYSFSPSGDEARTRLGLFKALLRQLVPQAPEVFKGIKERFDKIQSCLPPKQQVAWNAQELFDELTKVVPKILRTHSVSIYVDGLNYSEGGTAPKLVQDFSKLVEKSRIPTKDPTTTHRLRIIFSSTPYPMKDPFPRSCIQVDEKNGPSLKKHLEGLLSNIDLNTQLLVSTKAGSSFISARLIVNHIKLFGPGQSSLVQQPSPTPAPISFLLGAYFQDMAQQGSNGLLSLFKWCCLSSRPLSLPELRVALALDALPKVVSVEELSQTEYLTRYGSDESFQSWIKTTSWGLLEVVTVGGQKVVKPMHDSVSDFFITKGLDILSYKAQAASTTASPLQQAHHFIATCILRYLAILPKEPRWESMVHTDPALRLVGYAASWSYHITSAGLGKQEASKLLKVLGWPSDQTLNVLVKLGLGDLQGTLWTHLFAIYGHAYFLSVAIRKAGNDVIDVQDRQKRTPLHLAALHGHSTVSKQLLKSGAKTNGQAVSGDTALHFAVLQGHQSIIKYLLERDPNLINIADGQSHTPLFSAVFRGSSSAVKLLLDRRADLKALDTYGNSVLHHAVDIEKSSVIKLLLDSGLDVNRQNAQGRTPLHLAIVGDHSSAVKALLERRSRTDIADNLGRRALHEAVLSGSKACTQLLLKHRVAIDARDNDGQTALVYAIQGRHGSLLKLLLEGDTDINAMDKYGFTMTMVAVQASDEKLTRILLEKNPDLDRLSHEGHTVAFYAVFRGKAVSFLSEEEQSIASLLFRRYQKRYQVWHPEWKECKQEFMAKHGKKKDASSNVKSKAKLSKAKNAPLPSNKDAASKPRRSSKVPANVVSKTHSSVPKQPDEPKRLQEAQRPPKPAPQSEVAGKPQSQCQNQGRPQTTANTSAPLAPSNSVPKVSTGVQGNQMNTPSNSMAAPVKPGVQQARPVSSFAGYQPPWFPSGSESGSGLDAKAKEQSSKPAQAPYPGSPSSTSAPAKAPMVQRGSWDIYSSLASGSPAPAQTVQSQKAYVPYPGTPQTSPGASPASAQSFQTLQPVSAGRAQKTSSPTAPVPLSQFEKRYSVPSLNSWGQPGSGSSVSTSPASQNTPTQAYQAFVAASQRPNMSQQQINAPYQKPVNPLPSAKPLMPQVIRKPVGGQPIVPAEKPIQQSSFLRWQQPQAPSGAKSPPVPMQAQVGTTQSLPRKPHVPPQAPTSKSQAPPSTTQSTSGKNQSASGPSGPVPYLPNKAPASTGTSQPAPTKDQVHPLTAQAPPGKPQVQGHMPLRNPQAAPGVVQPQMAKPQGQAQTHPPSGKTAPIPSKSQAPPEATQTQVAKPRMQPQAQIGKPAPVPPKFQTPTGAAQPQTAKPQAQDGKAETQAHKMQGPPGTSQTASGKPQGQGDLPSQKPQVPTSKAPSQPTKPSIQSGTSAQKQPAVPKPSVVAPAKPFAAPIQTQKAIPDQRKPVPSHIGSSRGGAESPTSIPVQGTSGQKTHQYIDKNSTISPVPHYPEPFYRGQYGEQTQASTFTSTREFTNSYDPNTQLTGTSSMSSGKMAAAAGVGVLAGAAGGYFLSSEVREDHSNPSITDESSYIHMDAGMSQQSAYDSDGELETHVEFSDHSEEFSESENDANSINDSDSGGFLSDEEYELSDSEVSGGQASSDDEISDWEESDAESIHEVSDSDEIDLDSPYMSADFTDDEASEAEDLGACGLQAESDSDLNTDPGQVSAGEDSGSDEKESVNNESDDELEESVQSMGFQQHSYTNQHYQQQGYLNEQYQQAIPEEPEFEEYVQPDFQPQYQQQGYFNSQYQQQVAQQSDSEEDEPRGFHQQHQQQSYYYQHNQVAEQIESEEDEPQSFQTQQHQQQQGYYGGHLQNQGPEQSESEEEPYQQYQQQGYHRGQNHQQATQQYDSEGEEGQQAAQGSGNYDSNQEVESDQDVNNGYSSDEQGQQAASGQYIGGGWGNNYDSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8T3</accession>
    <name>S0E8T3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023577996.1"/>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49249" checksum="9B85CE1EDDEAD7AE" modified="2013-09-18" version="1">MAVALPRRFYSLLWVAVLLALVVFFIFLREDTWSSIPRPPSGWKIPFTTDDGVLSSWMGGSKKKGKDPKEPLRIMLVESSGTHDEVAAALMHAFGNQEGSSLDVYFANQRFNMQGIMANFTLAANVTINKWDKFANDVTENPPHILVSTTCEFDLDRGTDPIVNLLKTANTHLFCTIHHADRWAQGKYVQAVRSWAEHERVDFVGLSQHTVDFFLNDTIPKWHTAANLTTRVIPPVFPVHISDPDLQPGISLSLQGDYSDGRRDYNGVFNHLGSVIRKASEESEGHSPQNVSLHLVGHGTHPEVPDHVKDHVFFDEGLSYPDFYTLMSKSFAVLPAFASETYFDRKASSTIPAALIAGAPIVATEELLKAYSYLPREATWVARPGEGEMDVIERVIDDRDGFIKRRQAVRDFTKSLLEQNQANTKAWINEAFEKYNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E915</accession>
    <name>S0E915_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432351.1">
        <property type="nucleotide sequence ID" value="XM_023579527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E915"/>
    <dbReference type="STRING" id="1279085.S0E915"/>
    <dbReference type="GeneID" id="35399703"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06226"/>
    <dbReference type="HOGENOM" id="CLU_112091_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="154" mass="16841" checksum="04EAAE1865FDDD21" modified="2013-09-18" version="1">MASSLPTFPRIVFTIIEPISLVVGFAGAVIDPAWFIGEQSPQKNDGDASPNSIVIAWQLGNLYLLLAFIGVAILSTTTENRVVRSYLIALWLADIGHVGFSSYGIGRDRLLSPLQWNAMTWGNVGMTLFLFFTRTAYLTGFFGPDHVNKSVKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9W3</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433780.1">
        <property type="nucleotide sequence ID" value="XM_023581125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9W3"/>
    <dbReference type="STRING" id="1279085.S0E9W3"/>
    <dbReference type="GeneID" id="35401677"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08201"/>
    <dbReference type="HOGENOM" id="CLU_024110_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="464"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="567"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="671" mass="75954" checksum="DAE080254E631E34" modified="2013-09-18" version="1">MDDIHLPIAIRRSRRSSIKPEPDMPSSPMPSKTPKRSSRRVRFSDPGASSSGLTPMVNRFTVATPKRRRHSSLPVQTTPSTIRSKPALPESGEVTFLPLRQVLDGRVQRRIRRNGLSEEMNTIQQEKRRRNQEAKDEIEKLRNELKARDREIYELQNATIVIDTDRIWDLEKQILDLQDELTKRSGRAMDQSRGYNWTLAAREKFSQDFMDMTPDEDQFGDETMAQFICSTPSRARTSFMTPPATSPTVPGTPIFEPLETTAMVGVQACLPDPKQLQLEEEVSSLQLEVAKLTDTLESYKTLSGRLSDKLSDFTPRDQSGLEAQIDGMLQAMSDRTCALQTLTSSITKLGFTGSDASDMITTLITNFRAARLELEYLTPGEITLPLSSHGAEVLDLMLTRLRDMAKRAKEDEDAIDEYHEIELSLRKQLDARVTVMDGLKAEMGKAEKLISDKIARIRELEVANQRLKGAVDGYIRDISELEDLVQRMEREAHDANDEYAVQLEVKHKILTRKEDTIASLESKLSSALTRSTDLQAQMLSIQTTNTQTISELNKKHGSALAARDASVLKYRSEIDKLNESLRSAHDKICGLRVENGGLKRQVDEERVKAKEVIDAMKEELERVVKMSQEFLTPRKEESEVVKGQGVRRVSKRLRGRDSGMGLLDEEEEEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9X8</accession>
    <name>S0E9X8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023581152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9X8"/>
    <dbReference type="GeneID" id="35401654"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08178"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="405"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1107" mass="124230" checksum="6BC7F36ED077863F" modified="2013-09-18" version="1">MKNMLRILSAFHHVAMDARESPQIEIQISPEQIPSTGLSVVYEPGDDATIVEYKQGSENAEKKPKNQEPKTSKLDNPKRLELRQSFKALLKRPSSKARQDSVLTTSTVQTSPAAPENDLSVFWPADLLPITCRKARILTFGYNTKITKFTSGPTNMNSIYSHGKDFLFSLRRNPIPGRPLIFVAHSLGGLLMKEMLALSSISEKPEHKKIIESTAAIVFLGTPHRRSPKLAAIGDWARSIVSSLRFQTTSTILDTLGLKTTDLEQSLGLTGIGLGVLGDKVVPHESSLIGDPREHAETLQANHNQLSRFSSAHDPNYIKVAGEIKALYNAIESAHDQNKPSQKSAPGIRHQTVKSVPLMSDVCQPLSETSLLDFLDRKILNDFLSSLRFQDMNARRDSILPPSLNTGSWLTKNEDFEKWQTTSDKNQHLLFVKGKPGAGKSTLMKETVRRMQHSLILHKDRVCASFFINAGGQLLHRSPAGIYRSLLYQILPETSICNPSASRGLDQQALIQTIQESVLQSGKIRNEQQLQTLLTQTLRLMSSTGTPIFVFLDALDELGEVTQSHQVDFWSELVQSPDLQTLRVCLSCRHFPNISVTGCLELKADEYNRQDIFNYTQRRLKARIASDEGIWIKEIASRIYSLSEGVFLWVVLVIEDVLKRYNLGIGLQMLLYKVESMPSELDGLYSEICGSLTRKEVPVARKMFQWVLAASRPLRLDEWHHIIAFIRPLKPSSLTHWRNSGNYTATDDHLVRQIKRLSMGLLEVSSERPNIKPGGIAEVSSVNAGAGSMDHEQGSARVVRVIHESVYDFFINKGGFQKLCLETADPLLDCHYTIIHTCLDYLFIPELDEFVAARQRLNSASVSTSSFHSFPSEEPRRSRPAPQDLIVRYEFKNLRKLPTLDSNRRVENWLAEHGLLPSDGSIVGSRRYSVTHESIGIASRVLVHYPALLLYIMADFQYHIEFLSTSGAFGSPTWYELLSRLRDKKVSDRLMALQRENHRRDRTAEFLRGLPEHGPQLAQRSKPLSTQSLGNPRESGGRDWTVEFLKSLPEKEWPPLKASRTKNNASGHGHTQLKGLGDLEVLRAFAPRVATVIVAAATAMKVMGRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA73</accession>
    <name>S0EA73_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
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            <begin position="245"/>
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        </location>
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        </location>
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            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
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    </evidence>
    <sequence length="372" mass="39362" checksum="088CB61B0133FA1F" modified="2013-09-18" version="1">MAQTQPPTFINLPPPTSRPETPSEMPGTPTSTTTSLSALSTTAIKDGHRGHFPQGPLSRGHQHNPSTQSLEAERADRISRLAGLERVSTLRAPPQANAQGASSPSPQTTPTSTTGFPPNYPATQHLTPAYFDSNGQPVAVTKMSTVGTASATESHVGDGDDTRTTAGEHDEDMFSTDTNYREAESVASMGGYPDAMDEDLDGVNARSVAGYDDRMSDDGSASLVGFGEGAGSTVSGPIYHRRTAPQAWGLERTNSGLSDARRERDTHMGGDTPVSMSALQERRDARMMDGVATDPNPGQAPENDSFVDTTFRGPVSASQPQSQTAAAQEAAERIVQRLDRGETRAPASGLVGPGRGDEPLGKFYFEGEKRDD</sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
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                <person name="Proctor R.H."/>
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                <person name="Humpf H.U."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
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            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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            <end position="83"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="102" mass="11080" checksum="FDF0208FC9CE25E6" modified="2013-09-18" version="1">MASVESQVSKQSEAPLQNDNENAEQLATLAEGKVADAVKGTSSRDKPRKDDIKIEDYTSDLEKKKSEQAEAREEIKTQRKAGVDVDGSLGQGRLSNEDNSSV</sequence>
</entry>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
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            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
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        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="46"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="359" mass="41332" checksum="ABFCC0463FCFCF14" modified="2013-09-18" version="1">MPLHLLGKKSWNVYNADNIARVRRDEAAAKAAEEAEEQRMQEIDAQWRLAILRGEAPPPIEDDEAPKDEEPPARDRDASQRTSTRRKRKRPGEDDTDFEMRIARENDNSALVRIEPEKKSTSSAPLVDHNGHIDLLGDEKSRAHAEKNEEAEKEAKKKKQSYEDQYTMRFSNATGKDGVLKPWYSQSDAAAPDASSKDVWGNQDPNRKERDAKRIVSNDPLAMMKKGASKVREIKQERKRFQEEREKELKQMRRDERHRVESDIRVAIVTRRDLPVDMSGDTDQEKEIIAAVVILIHEAEDMSVMIEKGHGRRGDTTRRVENEKRDPGETMDIKKETHDLQRGFIMNDDYTIPKTDSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAM1</accession>
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        <recommendedName>
            <fullName evidence="4">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05405</name>
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    <organism evidence="2 3">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023578612.1"/>
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    <dbReference type="STRING" id="1279085.S0EAM1"/>
    <dbReference type="GeneID" id="35398884"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05405"/>
    <dbReference type="HOGENOM" id="CLU_001305_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.90">
        <property type="entry name" value="Immunodeficiency lentiviruses, gag gene matrix protein p17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012344">
        <property type="entry name" value="Matrix_HIV/RSV_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="76845" checksum="9D8EAA0A10B9105C" modified="2013-09-18" version="1">MDALNRAIEAAERMVAAMPPGHSDRAELLNDLGICHAAKFDVSSSIEDLDRSIDVADAAIDSMPQQNPDRPRYMDNLAAGLSRRFRLIGSMDDLNCAIDLVDKAVEATLPGHIYRNRFLGNLAIWLCKRFEAISSMADLDRAVWAADLAVEALSDDASQRANYLSILGNCLGRRYQHTDSKDDLDRAISVAELSLEAPGQDADHRAAYLSTLGLWLGVRSGRTASKADLDRAVEATDIAVEALPPEHPERIMCLINLVQFLCSRFQLTGSMSDLDRAIEISDAGLELLLPNSTSKTAWLKNLASCLSNRFDRAGSMDDLNRAIQVAELALTVTAWDHPEQTVCLGILGLCLGKRFDRTASMDDLNRAIDVESTAEEAITAGHPFKTDHWDALGVWLDRRFDRASSMDDLNHAIDLAEMAVEATPLNHMDRASYLNNLGCYLDKRYERTGWMGDLIRSLSCFKEGWNCPGTPTSIRIRLALSAAETYASQSNWEESNQLLKKAVELLPAVSPRSSSHNDKEHMLANFVGLASTAAAVAWNAGRDPYHALKLLELGRGIIANLLMDMRGDISDLKQRHADLADDYISLRDELDSTGDKPSPSVPSNGASSLESQATRRRKADQRFTDLIAEIRARPGFDSFFFPPTADEMMVAASSGPIVVVNLSSYHCDTFLVQLDHISVVELPDLTLEDAQRQAYGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB70</accession>
    <name>S0EB70_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431778.1">
        <property type="nucleotide sequence ID" value="XM_023578833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB70"/>
    <dbReference type="GeneID" id="35399083"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05604"/>
    <dbReference type="HOGENOM" id="CLU_059761_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="418" mass="47179" checksum="C6E98C0226241472" modified="2013-09-18" version="1">MAYYRPSRQQARPYGYDDGYVAPDPGRSYDPHDDRNAPPPRKVRREPATDASPPRRYKSQRSRRPPSPSRPVYPDDPMMDDRRAEGRPRRRYEPERRGRSAGPDRRSRDISPPPFGPPPDSPRRKARSARPDRDSHHPEREFRQTSREPRSGRDRDRDRDLPIRGKRDARPDRDPRFERDAPPVHPYDRDAYAREPTSRAYPDDPRDQRRSKHRDANPESPRRHGRSVPPPPRSRSQGRGRKSRYPESDSDSEDDHYGAKLGAAGAGVGAAAAASRRRPRSQTRDRRGRDPARSPNRGRPPTTQKNRGSAPTGRRSSMPASTKPRNAWWQNPMVQAGARTAFTAGAQAAMKSGRESGPWLGPKGAKVATAALGAALVDGFMGQKHPNSTRQKLMREGIDLASAQTTRVPEHHGSGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECK0</accession>
    <name>S0ECK0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434759.1">
        <property type="nucleotide sequence ID" value="XM_023582193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECK0"/>
    <dbReference type="GeneID" id="35406028"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12572"/>
    <dbReference type="HOGENOM" id="CLU_1077832_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="256" mass="29722" checksum="708BFBFB1E53C118" modified="2013-09-18" version="1">MDHYNSLTRPVKEESEGYPVRRSDLEADKDFDVLSFIESYSDGHEVGHEMKDAEYRKQEERLMDLVIDFVRREATDENGLIATVNPHPKLSIAHDLVSFLLDRKAATSHLFRRHPIPSSTTPQPFPLNMFMGKWTSWTSFTLSKSKEFQPGSRQCCQMMKPGDIEVITVSNEKFVQLMSLLTGDELLMMTIWETPDSSRYVSPHLEIMKPNFGLVEERGERVIAWRVHGLDTSYYMDRLGYRIPDMVWPLQEVSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECL0</accession>
    <name>S0ECL0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to fluconazole resistance protein (FLU1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_08380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433616.1">
        <property type="nucleotide sequence ID" value="XM_023580926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECL0"/>
    <dbReference type="STRING" id="1279085.S0ECL0"/>
    <dbReference type="GeneID" id="35401856"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08380"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="88"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="536"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT71537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="566" mass="63239" checksum="4B0F4A9D1F33CFB2" modified="2013-09-18" version="1">MAASESSETTREPSPYRGRRRSSSFSDHIHHLDEIEAQSRYEEEAADRGLGALHNIRSRTRSRTNEVLVTWEVDDPENPVNWSDTKKKLVLLCTSVLVINSTMGSALPSMAIPDITKDFGITSEEQSVLPISVYLIGYVLGPVVWGPLSEHYGRRDLSLVTFCLFTIFTMACALAPTWPALLIFRFFCGAFASSPIAIVAGILADVYNDPRTRGRAFAIFMVCTTGGPILSPILSGFAGPNIGWRWVFWIALIIAGSTLVLIIFLPETYGPILLSRRARKLRKQDPSSRAIAPRDLETTDLRQLLTVVLTRPLRMIISEPIVTTSCAYLSLVYSIFYMSFQAFPIIFQDVYGLSPGVTGLAYLPIFGGAALTLPIFWTWDNTLARATERNAPWVQREEYRRLPLACLGGPLFVVSLFWLGWSARAEIPFAAPMLAGVLFGMGFMLIFMAILNYLTDAYEIFAASANAAASTTRSLFAVVLPLATKPMFRQLHINGACSLLGGLSTLMCFIPFVFIWKGPSIRSRSKFCIALRERKEEMQRKEDEARARKERYELKSEKTEKEKETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDG5</accession>
    <name>S0EDG5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434743.1">
        <property type="nucleotide sequence ID" value="XM_023582173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDG5"/>
    <dbReference type="STRING" id="1279085.S0EDG5"/>
    <dbReference type="GeneID" id="35406009"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12553"/>
    <dbReference type="HOGENOM" id="CLU_010432_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="727" mass="80293" checksum="183EB8B3D6601C19" modified="2013-09-18" version="1">MTPRNSSTRHRGRPPPGVKGQSSPEYPSYRAYHAASRIHQLSGMWPNELCKGFVPDMWGIRLIEGLSALVSLVVSNGVDVEEVRRRLKGHANHHPRTKYPQLRKSDILKVRKWLRGMGIDTKHTNLNESVSVNEQSDDEMGYSDATEADSEPVDEIVALGLPEDQIEEDTDEEEDENEEEEAEEQVDEPEQVQEDEAEEQDEEEEEVEELEDENDLDWAAPKKQSTPRERRRSPAKEVVEIEDDESDEETVVDPGGDEFMPNDSPEPVQLNGQSGPDHGTSTPNSVSVASTRPRRSIQQPSRLVSDLPRSSVQQSTGSAEYTSATLAVRSPPGSQQQTPSSQVPVPKPATSQGDMRPPQQPTPTASPANTIQNFARPRPQSHTAVPLPPIPGTKNATQLQRSNSQPSASTSASNSQGSATPRTQVSSQPLASPRTSATSLTPQQQSGNWSSASNPVAPQGAYNQLASSQQSTPHHLAPSRGNKRPAESLPTTSYASNSPSNASRSGAKRQRSSIAVPHRQSQVSRAINWDAILPSGDEFKESLKHASDAIKPVLRKFEELLADINDEQRKLSAVQSSLFQKKNDYTNDQKKAQDALKDVENSTANENTTLRGLEEVYQQNPRDAELRTFINKRKQTILEHKEVYVIVKSQLDNSIAGIYKTDHEIALVTKRLGQLDAERADVLREKEGVDKAAKRVTIMSKFMEPSWQATLDMLLQSVGPEVLEKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDY5</accession>
    <name>S0EDY5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to Zn-dependent hydrolases, including glyoxylases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_06602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432692.1">
        <property type="nucleotide sequence ID" value="XM_023579945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDY5"/>
    <dbReference type="STRING" id="1279085.S0EDY5"/>
    <dbReference type="GeneID" id="35400079"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06602"/>
    <dbReference type="HOGENOM" id="CLU_030571_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07729">
        <property type="entry name" value="AHL_lactonase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="51"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="278" mass="31392" checksum="632B00E5E9FE4A08" modified="2013-09-18" version="1">MQPNYEVAPEGARMWLLHIGNLVADEGVFLPFGNVCTASHPISESKRRHLVMISVLIEHPEDVLLLYETGAGKDYPEVWGPRLADIFARGEHSEDMELDAAIKKTGHDIKDVKGVIIGHLHLDHAGGLEYFRGTDVPIYVHEIELKNAFYSVVTKIDIGVYLPTYLQFDLNWTPLYGDSILIARGITVHLSPGHTPGLCIMQVNLKESGTWIFTSDLYIVQENYDNLSTQGWLTRDHAAWSQSNQLVHMLQKARGAKVILGHDRDVLMRHKLAPEYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEH8</accession>
    <name>S0EEH8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435449.1">
        <property type="nucleotide sequence ID" value="XM_023568100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEH8"/>
    <dbReference type="STRING" id="1279085.S0EEH8"/>
    <dbReference type="GeneID" id="35403409"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09942"/>
    <dbReference type="HOGENOM" id="CLU_024811_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="3">
        <location>
            <begin position="437"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="668" mass="72515" checksum="1CA5CFB448A60DCF" modified="2013-09-18" version="1">MNLENANTVQELQRQLEAANARNSQLEQFVQSQFRGDPTVLNQVAQNLSLAQPGFQIPSHGLSSARSSGLSRSKSTITYPTQVKSAITERHNGLQAHKRERRAFSQQSGSALPMSRSVSNRSESHMPFSQTGNRIAPLSASMDRFNSSQNESPNLPLEGVSDRLPSVQENQPLLNIGMDPDEFLKQWPETAQVPQNFDTSYSGLPYNMVQDNSFSNLSSNIPSSYPMSSACPSMISGPSAAEAASPLTRQNSSFDSYGVGMERLESSQSQADALFAPDLSPSSVNMYPTSKQFNSEQDLFGLGANLSAVNMQYTDSNGNTFMTSPESTDMERSCSNTSMSSVRSNASNLERRAKEARERVLHSGKTIQLAPKPKEEVAKAEAVAAANKEAKLPVNKSNYQRPKHPKVYCTQCTEHPDGFRGDHELRRHVNAKHEGTVKKFVCRDPATVGIESNVKAVNPLSKCKACVSGKEYGAYYNAAAHLRRTHFKPKTPRGKKGANGDEKRGGKGGGDWPPMNDLKAWFVEKKVKVDLNDSPMAEQDDVDEMADDNMDGSGMPHQMDMFQGIGSSMAPFNMETGYDLTVDGTADPAMMASVNGELGIPAPISSASGNFGYSPFNGSPIGLADNYAFSEHATSAYGSNLSSTNTITPANFQDMSHMSMADNALWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EER2</accession>
    <name>S0EER2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435332.1">
        <property type="nucleotide sequence ID" value="XM_023567964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EER2"/>
    <dbReference type="STRING" id="1279085.S0EER2"/>
    <dbReference type="GeneID" id="35403531"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10064"/>
    <dbReference type="HOGENOM" id="CLU_070658_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03194">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03043">
        <property type="entry name" value="GST_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="230" mass="25920" checksum="29D3B70BFCA94F6F" modified="2013-09-18" version="1">MTYSLFIGNKRYSSWSMRPWVLLKALEVPFDEKLNLFKPGLRQPDFLAFSPSGKVPCLHDGETSIVVWDSLAICEYIAEKYPAAWPTDAAARAFARCAAAEMHSGFDAIRDECSMNVGLRIELGTPSEALQRDINRFNELFKEGLDKFGGPWLAGDKFTIVDAMYAPIASRVKTYGIELDGAAKEYADRLFEHEAVQAWIQGGIKETSREPFHEEDCVRGRKVLKDLTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF05</accession>
    <name>S0EF05_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor SWI6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_09671</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor that plays a role downstream of the MCK1-MKK2-MPS1 cascade. Required for hyphal morphogenesis and pathogenicity. Is an important oxidative stress response regulator and plays a positive role in the regulation of extracellular peroxidases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435604.1">
        <property type="nucleotide sequence ID" value="XM_023568400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF05"/>
    <dbReference type="STRING" id="1279085.S0EF05"/>
    <dbReference type="GeneID" id="35403139"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09671"/>
    <dbReference type="HOGENOM" id="CLU_009666_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000365">
        <property type="entry name" value="Start control protein cdc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT73526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="792" mass="86257" checksum="7BDE288697045644" modified="2013-09-18" version="1">MSQQSQSGMGNSFRGYNGDSEGATIYSASYSGVDVYEMEVNNVAVMRRRNDSWLNATQILKVAGVDKGKRTKILEKEIQTGEHEKVQGGYGKYQGTWIKFDRGVQVCRQYGVEELLRPLLTYDMGQDGGVAGRGDFNTPTKEQAMAAQRKRLYNQSTDGRPNGLSGTFFKNISTTASHAVAAISKARFDSPGPRGRNGPSRAPSFSRQASMQNGDDFPSNSQQSFASDYGQQVDSAYSTQQINNSVQMNETEPPRKRQRVTMTPGDSFGGYGQNMDMYAAAFPGSPTEPNESFIYTQNTMQDGSPVDEGSGPLAPLPYEMSPEVEMKRNMLMSLFLEAPGTDPTKHDMLRSYTPKELDMPIDLQSHTALHWAATLARMPLLRALIAAGASPSRVNASGETALMRACLVTNSQDHNSFPDLLEVLGSTIEARDHKGRTVLHHIAVTSAVKGRNAASRYYLESLLEWVVRQGSAPNSQATNGNGPSASQSANPKMGIARFMSEIVNAQDSVGDTALNIASRIGNRSIISQLLEVGADPNIANRVGLRPLDFGIGSENVEDKTNGEVNVDKNGATGTNQRSRESSDEIVASISHLLSETGSAFQTEMKAKQASLDTLHTTLRTTSTQLGEARRTFEHLSATLKKQQLARQKVANLSHAREDEQVRLMQEQSRASQPNPSSSWETELSAMLEAADDTSGGGFGGEGLLPSAAVLRARIRAVEGRRDMTRKMVAALKGRSRDVEVKYRRVVALCTGVQEDEVDAVIDGLLKAVESEHEELEINRVRRFLGGVEGVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0EG55</accession>
    <name>S0EG55_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_09567</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435703.1">
        <property type="nucleotide sequence ID" value="XM_023568515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EG55"/>
    <dbReference type="STRING" id="1279085.S0EG55"/>
    <dbReference type="GeneID" id="35403035"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09567"/>
    <dbReference type="HOGENOM" id="CLU_015768_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="13">
        <location>
            <begin position="112"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT73625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="646" mass="72984" checksum="E9BF10C0713B1D0A" modified="2013-09-18" version="1">MRPLLSHPTRLSRNFMQYLVLYHPIPLLARRNFTSSVGRQHDQNSDIAKKASHSPSEELNEQRGRHDRSVKKPSRLAALKKRDQNVGNKDTKVKEGEANQRYILGQSANKPIRTRFAPSPTGYLHLGSLRTALFNNLVAKATAGGDFIIRIEDTDQNRLVPDAEERIFKDLEWAGLEWSEGPDKGGPYGPYRQSERLETYKEHTQTLLENGSAYRCFCDQTVLEAQKRALHEAGKSTAYPGTCRTLPRSESDERAARGEAHIVRLDSTRFGTPKFKDAIYGPFQKKEPEEDFVLMKRDGYPTYHLANVVDDHLMKITHVIRGEEWLISTPKHLALYEAFGWESPTFAHLGLLVSNNGSKLSKRDSSVDLSTYMDQNVFPMALQAWLANLGASTKRDAKTPRTLSDVAENLTYKFTRGGIKLNPTKLDFFQHEYRNLLTKTPSTYHTSREQELIRDYLVTPLVNEVHAITASSQSISDDYKPIQLTGTALDWPAPLSPVPAMLSSESSQSYTSKIIFQETVRYSSVANLARLLPYFFWRPPTDIYRAAIVSETPRLDLLEMVNKTVQGNENWETAVDRLFESIPSDQAPDLHAILRLIAIGDSQAVGKSSRILFDVLGQDEWRYRANLVASLLRELESSGQLSVSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH64</accession>
    <name>S0EH64_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436182.1">
        <property type="nucleotide sequence ID" value="XM_023568203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH64"/>
    <dbReference type="STRING" id="1279085.S0EH64"/>
    <dbReference type="GeneID" id="35403316"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09849"/>
    <dbReference type="HOGENOM" id="CLU_165034_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7445" checksum="F42752D9D147D31D" modified="2013-09-18" version="1">MSRGNQRDTDRAKNDKKRREEAERKKAKSKTGTKLQQEKESDAEKMRRKQAASDARKAAAGAVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH83</accession>
    <name>S0EH83_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436207.1">
        <property type="nucleotide sequence ID" value="XM_023568678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH83"/>
    <dbReference type="STRING" id="1279085.S0EH83"/>
    <dbReference type="GeneID" id="35402890"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09422"/>
    <dbReference type="HOGENOM" id="CLU_062857_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="452" mass="51161" checksum="9E2EBF15AD82B967" modified="2013-09-18" version="1">MSPEKSQYTGDVCHILFRSQGPLLIPRTIVKKCPKLAARLDKRHIFSKPLDTVDIEDYPFSVGHILIHYLTTDKYECLQPEGETEDERNCSELATAFKAHAAAVDLELPFLQLLASSEMRRLEGKLSLVLITRTLNDTRLPLDQYPMITANFVSCVIRLSASPSKECKEEMMNQLGVPENVAMVLMKLLLQSKGMTLTRDHSSEIGSEDEKALNTSQLEEEECELLTILETLDKEKARIYQPTFETGVREKMAREALATTILETWEASGGTLSSLQHARLEELRNISDKLSQDLDICKTDLEASKKRVQQLKVEAKAILERLALEHEIQSILERQKQQNGFLDLSDRLRLRSAQSRCCDHSNAASVDARVHLNTQDSEMGPEQEEENQPDDDGFRTPTRTSCNMRHRQLSNVKGADDELEEVCARLREFRDFVSETTSTSGRDTPPSTSSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHX6</accession>
    <name>S0EHX6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436472.1">
        <property type="nucleotide sequence ID" value="XM_023569227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHX6"/>
    <dbReference type="STRING" id="1279085.S0EHX6"/>
    <dbReference type="GeneID" id="35403907"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10442"/>
    <dbReference type="HOGENOM" id="CLU_836891_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141:SF1">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="340" mass="38205" checksum="BFC8DFDFE7371BD2" modified="2013-09-18" version="1">MLFQDLATEIIELIVQNLTVRADLNAFCQTNKRFYLISNDHVYREDAHWRCNALRWGSEEGLISVVERSLDQGADVNYIINYEEETALFPAVRKQYWDVVHLLLTRGADVHHRNKVGDNLVYFAVTTGSYDLVKLMLDQGVDPNSHVEGDAPPLLLAVRRGYTDIVRLLFDSGAYIDDSDDWGETPLHIAVSAPQRDILSFFIEKDVFRKDKAGARGADALEMAVIRGDMPTLTLLLEGGADPLVRRWTRHHAIITAALAREDDMAILMTERLVGELGFIGEHGKELLWYAVKGRCQRYTRYLLNMGLDPDKDLWKEVDGSMVGGSALVVEMLGAGVLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI49</accession>
    <name>S0EI49_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436413.1">
        <property type="nucleotide sequence ID" value="XM_023569160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI49"/>
    <dbReference type="GeneID" id="35403848"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10383"/>
    <dbReference type="HOGENOM" id="CLU_1151550_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485285" evidence="1">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="230" mass="25459" checksum="387767F06184DA97" modified="2013-09-18" version="1">MLFKSLLSSSLLLAVVHAGPTASGQVLAKRDGFPACDDTSRTYEGPYTDGEGTYVTSDRTTHPYKFPKVRKCWYDYFVLETSKEYTPWQKASGNIYCTGTQVCTATKLVGNEVCQERSESVSVSVGAEIEGFSLGLDFTTTDTESKCVQAQDLTACTWDDGACHTVWTQQEVMRQKGYRRQRCNWGNGDETQCMDNWEQTTPSDFISYGCGSKCTDTNDCGNTDGKPCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI64</accession>
    <name>S0EI64_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to general amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436784.1">
        <property type="nucleotide sequence ID" value="XM_023569590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI64"/>
    <dbReference type="STRING" id="1279085.S0EI64"/>
    <dbReference type="GeneID" id="35404233"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10769"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="130"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="279"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="595" mass="64891" checksum="9760409DCD6ABBEF" modified="2013-09-18" version="1">MTFASSSSVPPSGSSKDSSSVTIHSLQSLESRPLAPEMLPGLPVVQVKPVPLGTPEFEEKRAALLEVFAEKVPDELRLPLEVILNPPTDVTSIPSTCGILSPEDIIITETYDAVGLIEAIARRKHTAIAVARAFCKRSIIAHQLTCCLTQWFMDEAIEQAQKLDAHFEAHGRPIGPLHGLPISIKDHIQVAGTSSSQGCFISISDDDQDADIVSILRAQGAIIYCKTNQPQSLMHLESDSHWGRVLNPFNIHLSAGGSTGGESALLAMKGSILGIGTDIGGSIRGPSAFCGIYGFKTTSNVLPTRGYIKGAPPPAVLNIPLSTGPMCRSLRDMDLFMKCVLSSKPYLSDPNIVPIPWIGLETRFNRRLKVGIISNDGFIEPQPPVKRAISWARSLLSDSKFANLIELKEFKIFGAGEAWKQVRRLYWPDGGHLTKNGIISSGEPLHPLTEWICRDAEPLGMHTAVDLTAVHKERDEFRLAFAKSWSDQDVDVIIGPSFVGPACAHDTAFYWTYTSLYNLVDYPGAVIATPIRAESGEVYDAGYVPLSDACRHVRDLWEEGDFRGAPVNLQVVARRYYDNELFGALGVLKDVLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ74</accession>
    <name>S0EJ74_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436922.1">
        <property type="nucleotide sequence ID" value="XM_023569754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ74"/>
    <dbReference type="GeneID" id="35404379"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10915"/>
    <dbReference type="HOGENOM" id="CLU_065839_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="317" mass="37242" checksum="275C09C6BEC2ABBE" modified="2013-09-18" version="1">MAEFERFPELPRELRDHIWSMAVRDDRPGVHVFGHRFLRSGDVVSGTWAAPSWSRYFENLDKDRSDENISAYLIDGGLWTACHESRLIMEKRYEQSKRKPSHKETYPVHDRTKEVFKKTTTGCFDGTPLDLMTVFPHRDLFVLQFTDLQKVDWCFMGFEASMATAAEGFRGVKHVALEYNPKWSAELIHDRGDDIWAIMEGAFEMWSPVWKLWFIDHSLKRKKDAPVFKEKADNGNEINAFYASDRRLLEVDCYNSHDLEKEWEYIKPVEDKSDDGFSSSVFFLHDLESDLRDKSYQTCDNYQDPYCQIGILGWDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJH9</accession>
    <name>S0EJH9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437234.1">
        <property type="nucleotide sequence ID" value="XM_023569759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJH9"/>
    <dbReference type="STRING" id="1279085.S0EJH9"/>
    <dbReference type="GeneID" id="35404384"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10920"/>
    <dbReference type="HOGENOM" id="CLU_735761_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="376" mass="43056" checksum="AF9650F792DB001F" modified="2013-09-18" version="1">MNNKTIAMRHSYGPLRRKPRSHYKLPQLVDYTNYPTLAKKATESEGVKDDGNIQRSSELTQGMLKILNDRYADPGKIGAKNLVDWFMTRGGKEPRRKYQAEVVNHFCHSNELQELQSNSSNISSRKSCLIDDRTVNGTTSTCNGNRKPLTSHDSWKSFIMNPDSHALVSVMATAPGYQSNALVHFLYSYIAFQPYIRVSSKPQGLVTYELSFHLPFYSWKQTQHEPRDIRFRQDSSPLRKVHNMSCLQGNSPTAPMIDYLCQAQIAVCITPMDGGICTGYCFVDTYFQPEDERQCVEDYCDRGMQFDPFTTGKHDADMPILNPDDYFLMSLQHQLVVFKDEWMNTAKRFKERVETYVISSMLGISSITNSRAGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKV2</accession>
    <name>S0EKV2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436600.1">
        <property type="nucleotide sequence ID" value="XM_023569377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKV2"/>
    <dbReference type="STRING" id="1279085.S0EKV2"/>
    <dbReference type="GeneID" id="35404041"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10577"/>
    <dbReference type="HOGENOM" id="CLU_010595_9_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31901" checksum="30A99C9ED29B144F" modified="2013-09-18" version="1">MTGPQIYTLNSGRKGVEEHRLDYQHITWLHLTKTLIPDNIKSYLNSLGRPPAVADVGTGTGVWLRDFAPEVHQDARLDGFDVDDSKFFSPAELPSNVKLSFGNVFEPIPENLVGKYDLVHVRLLMVALKAGDWVPVAKNLQSLLRPGGYILWDETGFTKFNAVPITEAYQKWISTDVRYGLSVGRDVTSPMPLEGHFRKAGYVECSHIDFSSFSEGPEVQKRAGDTLVNYARQALNGIATKGEFEWIHSHEDVEKHCDILQQEVDDGVSVMGYEVRWTIGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM31</accession>
    <name>S0EM31_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antigenic cell wall galactomannoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437703.1">
        <property type="nucleotide sequence ID" value="XM_023570615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM31"/>
    <dbReference type="SMR" id="S0EM31"/>
    <dbReference type="STRING" id="1279085.S0EM31"/>
    <dbReference type="GeneID" id="35405150"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11689"/>
    <dbReference type="HOGENOM" id="CLU_091392_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF4">
        <property type="entry name" value="CELL WALL GALACTOMANNOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485448" description="Antigenic cell wall galactomannoprotein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18339" checksum="1ABAB11FF05592A3" modified="2013-09-18" version="1">MRLSLLPLIALAGSAFASGDSISTAIDNISNATLALNKTVATWPQTLLGALPITTKSTLLLTEIHKGFVIARESEPLSLEETLQVAKATSELSADVELTINTIIAAKPNFDRLQVSPVILLNLNLQRALSQDFSEAVISKVPKDLQGNAKALVQGIDDSFARAISKYSKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMG4</accession>
    <name>S0EMG4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_11852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437858.1">
        <property type="nucleotide sequence ID" value="XM_023570798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMG4"/>
    <dbReference type="GeneID" id="35405313"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11852"/>
    <dbReference type="HOGENOM" id="CLU_014819_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT75812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="540" mass="58347" checksum="364BA779F302902D" modified="2013-09-18" version="1">MVSSMIKKVLHLATVAISPVIAKPHSKCTAGTLLIPNGTISSVQHHVAGDVIPLPNTVASCGGPNFKANITADLCRIVISVSTSDSSSVRIEAWLPDDWNKRLLATGTGGIGGCIDFPTVQNGAQLGFASFGTNTGHDGEQGFDFFLNQPEVINDFGHRGIHVEAVVAKQIVQQYYGKKASKSYYQGCSTGGRQGLQNAQLYPDDFDGILAGAPGIDWLHIVASKGILARRIGWPDLTSDAYVRPEQWKAIVAKQIELLDPLDGVEDGIIDNPAAHAIDPVIMACGTGLFNSSICLKPQQVASVRAAYEPLADSEGNIVYPGFALGADTSVFSANQVNGTADLNYKVLQDFWRGAVYNDSTWTPHNFTVKDMDFAIKLNPGGVNAAEGELQKFYAKGGKIISYHGQADQTITPKLPAEYYAKVQANINATLENMHSFYRLFFVPGMYHCSGGPGAFDIGQVYPLKKDRLTAEENVLLALTKWVEEDQEPETIIGARFGSSGTPDKAKVQRKYCPYPYESRWDGSGNTTKADSWYCKLPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMK0</accession>
    <name>S0EMK0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable cytochrome P450 monooxygenase (LovA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_10299</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Plant hormone biosynthesis; gibberellin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437190.1">
        <property type="nucleotide sequence ID" value="XM_023569066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMK0"/>
    <dbReference type="STRING" id="1279085.S0EMK0"/>
    <dbReference type="GeneID" id="35403764"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10299"/>
    <dbReference type="HOGENOM" id="CLU_022195_0_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT75112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="514" mass="58624" checksum="98963F2132AFD458" modified="2013-09-18" version="1">MSTYVDTVLQNPQYAVLSAISLIAILVVNFSFFTQDEKYPVLIPKKPLELTDRRVVKEFLANSKSLLANARTIYKDQPYRAYTEMGKVLVIPPSWVDALKNNRQLDFLTPAKDASAGDSHQYIPGFGPFGFDPKMPTVINKYITKALTRITGPVSEESSLAIRDCLTDSAEWHAIRPQADLIRVVSRVSSRIFMGEELCRDEEWNRTSSEYTLLAFGYGGHLREYPRWLRPYIHWFLPQCWAIRAKLNEARACLKPHIERRNAIKQKALAEGEPCPFDDSLEWFEREYEKHDPAKEQIAVSIVAYHTTSDLLAETLLNLCQYPKVLQELREEIVDVLKAEGGMTKAALYNLKLMDSVVKESQRMRPILLGAFRRVATADVTLPNGDILKKGDKIIGNMSHMWDSDTYDNALQFDPYRFVKMRQTGDDKKAHLVSTSADHLGFGHGYHACPGRFFAANEIKILLCHLLLKYDWKLPEGCKPQPSFSGFKLLGDYSSNLLVRRRNEELDFDSLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMZ6</accession>
    <name>S0EMZ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="14">YCF1-Vacuolar `full-size` ABC transporter responsible for vacuolar sequestration of glutathione-S-conjugates</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_11331</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437360.1">
        <property type="nucleotide sequence ID" value="XM_023570217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EMZ6"/>
    <dbReference type="GeneID" id="35404793"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11331"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="857"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="959"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="221"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="520"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="826"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1133"/>
            <end position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT75313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1366" mass="148577" checksum="DBE3D400E23C49D6" modified="2013-09-18" version="1">MSTFSIFTLFYSGLTFAYILEIFLSLAKLGAKKPEYRKVWYWANFICALAHIGIIAICLTIALLPDTEDAARCQTSYLLLISTGAASLASLAAIIFDHGETLHALYTLSGAFAWGALCLLVPDAGTPYQVPDGAGKHPLTQTPFLPSITLSWLDPLLKRATRFELLTEHLWPIDEKLGEPYALTEADASLQRWRFLLPKGLARILLLECTGPLVRSGLLEIVGIVTVSLQPFLLGALLEQRRYTFVIALFITGMVGGAARAHARYQLRMAGMGLRAALTALICDRNLEISSAASVTNTPDPVILMEVDLPQVFALVEAFHTTYLAPLQCIIGFIALAYILTWQSMLAGFGLMAIGVPLFMLLMSLISQRLSSVMEAKDARVSTVNEMLAQVRQIKLQEWQSFFSARIDGIRAYELMEVGRVAILNGALVALSTIIPTGLVAVTLVTYAAMGGQLTSQVMFPALAFFFNINSGLQATSQLAMIYQAGVISLERIKDHLMPLDEPMPRKHLDALPEGPSVIVEEGTISTWQSGKGQRLLLRDINFEAVQKGLTVISGPLGSGKSTFLRSLIGDVRQLDSNIKISGTIAYCPQVPVLIHGTVRDNILFGLPYDPSFYQCVIDATALSIDLPRLAHGDQTRLDGTGAALSGGQKSRVALARAVYSRRDIVILDNPLAALDAKVRAEVIDQVLGHKGILQDQIRIVTSSCQPLVEAADRVYTIADLRLLQGAEFIEDPSLTSSIAEDLSRTEELLIRDESLVVPPTSQVGCGTFDVKSIATVHVTDTTEEAPLLGRHPTEVLASGQPNVEGVPLRVYISYLGMANRGGWYVVIVLAIMAKLADVAALFVLRLATEGAEGFHFLGVFTALSSVGSILSFVFVMAAYFLCLIPASRRLHDRLTKAVLESQFRFFDDNSPGQILSRFTNDINKVDSQLNAGLIRFVIAVVMALAPIAVIIATVPLSIVYLIPLGFLYKYVQAFYLGANRQLRRLENASREAIISVTEEMATGASIIRCFNQEQLFKQRARDAIDGYNITSGPFQALKVWLDLRLQLLASLVTLFSATLILSLNIPSGTLGLVMNFVLQITNLFNSLVEVRAGLEADITSYERIQMYKENHSEEDVDVSLDPPSNWPSEGSVVFESYTASYRPEGKPCLKSLSLSIPGGDHVAVVGRTGAGKSSIVLALLRAIEKDCTHGKICIDGLDLSSLSPGAIRRRIALVPQEPVVISGTLRENLDPLGDIEESDLRRALASCQVIEILGILQDEDPLEHRISRSNLSAGQTQVLALARAVAAKCKIIILDEATAALDAKVATAVRKVLKSKFGGCTMIAITHDMDSAKAYDHVLVIDHGQVAEYDTPQALIQNGRLSFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN50</accession>
    <name>S0EN50_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437425.1">
        <property type="nucleotide sequence ID" value="XM_023570292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN50"/>
    <dbReference type="GeneID" id="35404860"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11398"/>
    <dbReference type="HOGENOM" id="CLU_2277545_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485804" evidence="1">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="102" mass="10948" checksum="A2A005F38E00F6C2" modified="2013-09-18" version="1">MKFTLSALALVASANAWTMQFDCPRGSGFEGSYSGSKNKGCTSIPACVPGDHMVWGNTKKSNCVLRLYAAAPCAAEQEIGHSKENWDHKFGQAVFAWGVTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP26</accession>
    <name>S0EP26_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436666.1">
        <property type="nucleotide sequence ID" value="XM_023569451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP26"/>
    <dbReference type="GeneID" id="35404108"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10644"/>
    <dbReference type="HOGENOM" id="CLU_083054_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050135">
        <property type="term" value="F:NADP+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053024">
        <property type="entry name" value="Fungal_surface_NADase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059:SF1">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485524" description="TNT domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="TNT" evidence="2">
        <location>
            <begin position="115"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="224" mass="24175" checksum="4A32DCEF6F8E199B" modified="2013-09-18" version="1">MLPSFLLSSLLCLSTVSALPNPIVAERAACDCSGTRDGGSSSKDYICRDARLGPTKLPKKLPLSATVESYNRFGGLTPIQFLQTWTDEKGNYKYPPQNGFQLDANGNAINGSMVLQVGTLVDRFGSEYGSYVSAASAPYSQRALPPSNLATNPDTPDFPYNYHVYRVIKPLTVVGGPIAPWFGQPGLGAQFFTGETGNVKFLIEQNYLQKEDPSALVYKSDGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPM2</accession>
    <name>S0EPM2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to multidrug resistant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_11415</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437441.1">
        <property type="nucleotide sequence ID" value="XM_023570312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPM2"/>
    <dbReference type="STRING" id="1279085.S0EPM2"/>
    <dbReference type="GeneID" id="35404877"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11415"/>
    <dbReference type="HOGENOM" id="CLU_008455_0_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF52">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="45"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT75395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="502" mass="54808" checksum="63CAAF10090762C3" modified="2013-09-18" version="1">MFAETERSEVARSNESSEQPIIVQWNGPNDPGNPYNWSRKKKWFAVGLGLFATFISMMNGTIITTAHEAIGEDFNVSDKNFPHSYWPVASWGLGGALFSLVLLPIMEDFGMRLVFLVVYTVFLCFLIPVGVAPNYATLIITRFFSGGCCTILANAVAGIIGNVFATDRARTIPTGLYIMIYLNASSLGPVIGAAIFQFLPWRWIGYIELIWTGVFFPIFILAMPETRGSAILTARAKKLRKQGKNAYSQKELESKSILHDIWTSIQRPLYMLCTESVVFISTIWTAFSLGVIYVFTQSVEQVFTALYGWNAIEAGYVQAAIVIGEILGFGLCVLTNNWYYASASRNKEAPGTPIPEARLYAAVIGGFIGVTGGMFVYAWTSYSSVHWIGPAIGLMLVGLGTEAVVVSIANYLIDAYSNYAGSAIGATVLGENLGVAFLPLASSSMYTNLGFHWASSLLGFISLVLAAAPIGVFIWGKEIRARSPFMKSAMSKPMEFAISPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPQ5</accession>
    <name>S0EPQ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437606.1">
        <property type="nucleotide sequence ID" value="XM_023570502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPQ5"/>
    <dbReference type="STRING" id="1279085.S0EPQ5"/>
    <dbReference type="GeneID" id="35405048"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11587"/>
    <dbReference type="HOGENOM" id="CLU_070836_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="268" mass="30563" checksum="3E98BE92F334F0B3" modified="2013-09-18" version="1">MSDQTKSASFDYPEVFSAAPPPFSHALSTAGPSTFQSRFASITRHGRDRIRLTNLSEVEITDLHQIVRTFWPRGIVKVYPQKASREFKLGGCAWKYDPSGSKQAMMLTLQILEGMHVLGWVIYSPIEVTKSLSTNDALIFRKANHRPPPCEWLNVSFHGGDKLKTLNFPPTDLVNDIVATFMIDIQRHNVTPDRAKIKFKGYPWRPRDCDGAETQLKLLALLEIFERHGFTLYTKTSARFTDERSESDVLVFQRRKDWAAGKSLHDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ42</accession>
    <name>S0EQ42_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to NADPH:quinone reductase and related Zn-dependent oxidoreductases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438291.1">
        <property type="nucleotide sequence ID" value="XM_023571245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ42"/>
    <dbReference type="STRING" id="1279085.S0EQ42"/>
    <dbReference type="GeneID" id="35407573"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14121"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT76245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="421" mass="44889" checksum="F427E80584919E78" modified="2013-09-18" version="1">MKEAYTNKDLNVEIRDVPVPKPRPGELLIRTVVSGTNPKDWKMPKLMGGDPANHGDDIAGYVEAVGEGVTGFRPGDRVAAFHQMFTPHGSYAEYSVAAAKSAFHLPNPTTFEEGATIPLASMTAALGVYQRLQLPLPWSPVTVPTPLVVDGAATAVGAFAIKFAALSNVHPIIAIAGNGITFVDTLLDKSKGDIIIDYRQGPEHVNKELRKVAEKHTISYAYDTVSDEASLEMLSKVVYAENGKIMSVIPKEDSVIGGITVLGSNVGHIHESAKEGFKVGNAEFGATIYNLVSLGLADGWFSGHPYEIAEGGLAGLEGVLKNLEAGLYNTSKSIVLYLLAEAARDPGLTTGATFHFTEDPDQSHVAAAKYGIHAPSACASENGPRALTSNIIALEPWKEMNGVQDFRAKLRDSQDKQPAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI31</accession>
    <name>S0DI31_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to ABP1-actin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_01510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424065.1">
        <property type="nucleotide sequence ID" value="XM_023577906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI31"/>
    <dbReference type="STRING" id="1279085.S0DI31"/>
    <dbReference type="GeneID" id="35394995"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01510"/>
    <dbReference type="HOGENOM" id="CLU_013085_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11962">
        <property type="entry name" value="SH3_Abp1_fungi_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11961">
        <property type="entry name" value="SH3_Abp1_fungi_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000242">
        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000273">
        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000045">
        <property type="entry name" value="Actin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035719">
        <property type="entry name" value="Abp1_fungi_SH3_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035718">
        <property type="entry name" value="Abp1_fungi_SH3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="666"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="758"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="638"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT61984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="816" mass="85229" checksum="5966CE1A450FB2A5" modified="2013-09-18" version="1">MASLNTSINGPSIKSSYSSVVNGAPPSSESPTHAHWALFSVQAPLLNAFQDSGAKESILKVQGTGESDLADLIEDFSEGRIQFAFAKVKDPNSGLPKNILIAWCGGGVPERTKGYFTSHLAAVSKILHGYHVQITARSESDLEIDAIMQKVADASGAKYSAGSSDSPRSAAPPPVKTKPVFTPTASSRANPLVAARSKREENVDEDGWGADAPPVTRTQIEKVESAYKPTKVNIADLSKQPTATTSGSAPVKRDDTPGDVVKGGYQPIGKVDIAAIRAQAQKDQDDRPTPVKGSYEPVGKVDIAAIRAQAKPVASEKPQEDETRPVSERMSAFSQPAQSERLTSLPKPKVANKFGGAGGFSGTKAPTPGGLGFGAPAPAKSAPVGAASRTFADQGGKTPAQLWAERKARERGEDTSSTPAPAPVGSTSPVQPQKSGSEWKSGYSGKSWAPVQTGDYGRGVPGQISQENTGEQPEDTPASPSGVSALRDRFKDTAPISAGAPAPPAARPAEDDTTPPPVPSGRPSGGFALPGLPSRPAPADEQDDEREDPSAYQTATERERSPSPPRVAVPVSRGPVPEVGTPPEQRAPPPITPNQIDVPKESDLADDKEVSSTARFAGGAPAGIAVGAAVGVGAAAAAGALEREPSPEPEPQHAPEPAAQPAQESQVGYRAVIQYDYEKAEDNEIDLVEGDIVTNIDMVDEDWWMGTNSRGESGLFPSNYVELVGDDDSEQPTAAAAPPTPPPVAEPETQAQAAAAAEAGHTAVALYDYEAAEDNELSFPEDATITNLEFPDEDWWFGHYAGQAGLFPANYVQLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIQ5</accession>
    <name>S0DIQ5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_01074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424460.1">
        <property type="nucleotide sequence ID" value="XM_023567986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIQ5"/>
    <dbReference type="STRING" id="1279085.S0DIQ5"/>
    <dbReference type="GeneID" id="35394559"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01074"/>
    <dbReference type="HOGENOM" id="CLU_008891_9_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT62379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="537" mass="57227" checksum="24B21031D3D68B75" modified="2013-09-18" version="1">MSAPVAAPAPTAGGSSNATFRDKEKPMAVRSSNIVAARAVADAIRTSLGPRGMDKMIRGGKGETIITNDGNTMLKSMSVMHPTAKMLVNLSGAQDVEAGDGTTSVVVICGSLLGAADRLLSKGIHPSVISESFQRAAAAAVEVLHDMSLPITLSDTSSLLQAANTSLSSKIVSQYSNLLGPMAVNSVTKTIDLKTADNVDLKNIRIVKRVGGTIEDSELVDGLVLTQPVLKNAGGPARMEKARIGLIQFQLSPPKPDMENTIQVNDYRQMDKIVKEERLYLLNMAKKIKKAKCNVLFIQKSILRDAVNDLSLHFLAKLGILAVKDIERDEVEFICKSTGCKPIADIDSFTEDKLGYADLVEEVQSSGSRMVKVTGTKSVGKTVSVVVRGANSLILEEAERSLHDALCVVRCLVKKKALIAGGGAPEIEIAAQLSKQARSLTGTEAICWKAFADALEVIPTTLAENAGLNSIKVVTELRHRHEMGEKNAGVSIKSGGVNTNISKENVLQPLLVSTSAIELAAETVKMILRIDDIALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ36</accession>
    <name>S0DJ36_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to uridine ribohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_01219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424327.1">
        <property type="nucleotide sequence ID" value="XM_023581161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJ36"/>
    <dbReference type="STRING" id="1279085.S0DJ36"/>
    <dbReference type="GeneID" id="35394704"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01219"/>
    <dbReference type="HOGENOM" id="CLU_036838_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070635">
        <property type="term" value="F:nicotinamide riboside hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070636">
        <property type="term" value="F:nicotinic acid riboside hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045437">
        <property type="term" value="F:uridine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006216">
        <property type="term" value="P:cytidine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019358">
        <property type="term" value="P:nicotinate nucleotide salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="376" mass="40204" checksum="CFD9C557C27BE680" modified="2013-09-18" version="1">MSEGQVPVWLDCDPGHDDAFAILLAAYHPQIRLLGVSTVFGNASLENTTHNAASILTAIGMHDIPLYIGLGKALERPALHAPTDIHGVSGLDGTDLLPEPLVTPSPIPAVEAMAEALRAQPAGTAWIVATGALTNVGALLRAYPELISHIKGVSLMGGSIGDNFSDAPLGEVDGHPRIGNYTAWAEFNILVDPEAAATVFHTKEIAAKTTIVPLDLSHQVLATSEVREMLLYGPDAERTGPGKTTLRTMLVELLYFFAQTYADTFGITAGPPLHDPIAVAAVLIGTENEIPFFEWDAKHSQPPEHDERFEVTVITEGTFEEAKKGKQTGRTLAKLLPPGQQGVRIPRGVDTAKFWQVIEECIERADAKNAALALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJV6</accession>
    <name>S0DJV6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to RAD57 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_00768</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424741.1">
        <property type="nucleotide sequence ID" value="XM_023571385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJV6"/>
    <dbReference type="STRING" id="1279085.S0DJV6"/>
    <dbReference type="GeneID" id="35394253"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00768"/>
    <dbReference type="HOGENOM" id="CLU_013059_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19491">
        <property type="entry name" value="XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047348">
        <property type="entry name" value="XRCC3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="79"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT62660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="439" mass="47308" checksum="2670251C8A349534" modified="2013-09-18" version="1">MTDLLQILPSFPLRPFAALIPIIEQQALTTTDLLTLHPADIAKQTRLPILDLKRLIAAIQASLSDDLSPQQPLLQPAEEPNVISTLDEGLDAALGGGVPVGVITEITGESGAGKTQALLSLCLAVQLPPPHGLGREALYISTEAALATSRLAQMLNSNPILQQYDDLETRPSLDAIRSAVTPDLETQDHILDFQVPVLLSRHNIGLIILDSVAANYRAEFERQGSHGSNMAARSAELVRLGALLRDLARRHNLAVVVANQVADRFASSSTPRHAPPRSSGVSYESPLASRSMPPPSSTNLPGTPSSSLPFALQDPDGPPPPPALMLDHQQRWFTGWGDDPHASYSLKTPSLGLVWSTQIACRIALFKRPVYGRIRQAAPVTAEDDSDLAAPTLRGWRRWMKVVFAPHAPPTGQGLDGAVEFEVTMGGLKSIKIQRAKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJZ3</accession>
    <name>S0DJZ3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase</fullName>
            <shortName evidence="11">HMP-P synthase</shortName>
            <shortName evidence="11">Hydroxymethylpyrimidine phosphate synthase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_01889</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 2 Fe(3+) + 4 H2O = L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 3-oxopropanoate + 2 Fe(2+) + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65756"/>
            <dbReference type="Rhea" id="RHEA-COMP:16892"/>
            <dbReference type="Rhea" id="RHEA-COMP:16893"/>
            <dbReference type="Rhea" id="RHEA-COMP:16894"/>
            <dbReference type="Rhea" id="RHEA-COMP:16895"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:143915"/>
            <dbReference type="ChEBI" id="CHEBI:157692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:65757"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the NMT1/THI5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423703.1">
        <property type="nucleotide sequence ID" value="XM_023573685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJZ3"/>
    <dbReference type="SMR" id="S0DJZ3"/>
    <dbReference type="STRING" id="1279085.S0DJZ3"/>
    <dbReference type="GeneID" id="35395372"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01889"/>
    <dbReference type="HOGENOM" id="CLU_028871_6_3_1"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13650">
        <property type="entry name" value="PBP2_THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000187">
        <property type="entry name" value="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528:SF1">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SsuA/THI5-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT61622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="342" mass="38330" checksum="B44DAD8FA8EE8CD5" modified="2013-09-18" version="1">MSTDKITFLTNWHATPYHAPLYLAQAKGYFKEEGIKVALLEPNDPSDVTEIIGTGKVDLGFKAMIHTLAAKARNFPVQSIGSLLDEPFTGVVYLKDSGITTDFRTLKGKRIGYVGEFGKIQIDELTSHYGMTPDDYTAVRCGMNVSKAIIKGEIDAGIGLENVQMVELEEWLSAQGRPKDDVQMLRIDELAELGCCCFCTILYIGNEKFLAENPEKVRSFLRAVKKATDFVLAEPEKAWAEYVDFKPVMGTALNRKIFERSFAYFSKDLKNVKRDWEKVTKYGKRLGVLDESFEPNYTNSYLEWTLSGESSDPTGDQKRIAQLQKDVAASGGFHRLQAEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLI3</accession>
    <name>S0DLI3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_01325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425555.1">
        <property type="nucleotide sequence ID" value="XM_023579983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLI3"/>
    <dbReference type="STRING" id="1279085.S0DLI3"/>
    <dbReference type="GeneID" id="35394810"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01325"/>
    <dbReference type="HOGENOM" id="CLU_1070048_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT63474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="260" mass="29758" checksum="A77E49F5AADD2713" modified="2013-09-18" version="1">MPQNEYMERWRKLHGRRLDHEERVRKRTAREGHKASQDAQNLRGLRAKLYQQKRHKEKIQMKKAIKAHEERNVKTADEKEPTTPMPSYLLDRTNPSTAKALSSAIKNKRAEKAAKFAVPLPKVRGISEEEMFKVVKTGKKIQKKAWKRMVTKPTFVGPDFTRRNPKHERFIRPMGLRYKKANVTHPELGVTVQLPIISVKKNPQNPLYTQLGVLTKGTVIEVNVSELGLVTAGGKVVWGRYAQVTNNPENEGCINSVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMF0</accession>
    <name>S0DMF0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to DEP1 protein, regulator of phospholipid metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424608.1">
        <property type="nucleotide sequence ID" value="XM_023569729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMF0"/>
    <dbReference type="STRING" id="1279085.S0DMF0"/>
    <dbReference type="GeneID" id="35394402"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00917"/>
    <dbReference type="HOGENOM" id="CLU_012439_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="562"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="634" mass="70704" checksum="5FC0260D7A15619A" modified="2013-09-18" version="1">MAVTASAPAPLSSPALGVADHEDSNISSPLSEVDTKDDNDEDIEHMNLDHDDEDSVRRSPRKKPPPTDDSDSVLSDAHSDVPSDGNVTEAETERLYDTPKHQRQRDVVVDQYNEGQVYEHTPSKLRRTANMHNDDEDESAIDDDDDSTGSPTIGEDSPTKHSIAHNAGHEDEHKNDAQERKRKRSPAADQSETEQPLRKRASSEHATDVNIPQQPEETVLQDGPTPAPESTGTHTPAEDTDASPQKRSTNRETDLAERLSRAVKKNTRGSKRKAAAAVADPDPDTDSGSHDGARDSARGTDVDHHDEADADADEEVDSATAHDEELERKQAAFKDWTVIEEMFGVFRDRLYKDRLERLEEEEQSLLASEPTHPEYLNMKQCLDDRLEQKLREINNEHEYRLKAHERRSVAQRAQIWGQYYQAVREKRERTLEALNQEWYDIQTARRSAHSLQDCGLLYPKDPAQRVRNAIAYNTEVSALATIAKYKGFPAGPEMSGATPSELEDDIAAIERAKRSRHKPVNQRREEYYAQPFDRLGPAGEQFLRETPWANPNHLLHKVHPTAASTEAPPDEMTSRGAHQASVPPGAQITQSPPLSARLSESPELTRTLLSPAHQAKRVGNRLPGVNRGTKAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMM0</accession>
    <name>S0DMM0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable ribosomal protein L31.e.A, cytosolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423889.1">
        <property type="nucleotide sequence ID" value="XM_023575772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMM0"/>
    <dbReference type="STRING" id="1279085.S0DMM0"/>
    <dbReference type="GeneID" id="35395187"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01702"/>
    <dbReference type="HOGENOM" id="CLU_112570_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="122" mass="13907" checksum="7DEF6293FD13C843" modified="2013-09-18" version="1">MSSKKPSGKTQRSAIADVVAREYTIHMHKRLHGVTFKKRAPRAIKEIKAFATKSMGTSDVRIDPQLNKKVWEQGIKGVDYRLRVRISRRRNDEEGAKEKLYSYVQAVNVKNPKGLATVVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMX4</accession>
    <name>S0DMX4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425872.1">
        <property type="nucleotide sequence ID" value="XM_023571590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMX4"/>
    <dbReference type="STRING" id="1279085.S0DMX4"/>
    <dbReference type="GeneID" id="35398532"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05051"/>
    <dbReference type="HOGENOM" id="CLU_043838_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31631" checksum="251B31ECD7318EE2" modified="2013-09-18" version="1">MMRLYLLPLSTRRTLLYAKRLEANTAPQGRTYVDKGTAWAAKTWAQWEKMESGWKRKVVDYGNYAFRRIPYEEWGLKSVPPLSVRQRGKEVEMKEKVDLCFPSSVIPPNKAEGILKTLATERQALHKKRLVWCIVGMPITIPFALVPIIPNLPFFYLVYRAWSHGRAISGGKHLQWLLENRLLRLAPSEKLDQLYALHAPPAEEPDNKERTLLTQKEVQTFSDTLDMPALEVELERAIWQVEQAVQDPDSPSPPKESSPGAAAEKPGSTETVDRKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN60</accession>
    <name>S0DN60_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Atos-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425961.1">
        <property type="nucleotide sequence ID" value="XM_023571700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN60"/>
    <dbReference type="STRING" id="1279085.S0DN60"/>
    <dbReference type="GeneID" id="35398433"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04952"/>
    <dbReference type="HOGENOM" id="CLU_010290_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033473">
        <property type="entry name" value="Atos-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025261">
        <property type="entry name" value="Atos-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13889">
        <property type="entry name" value="Chromosome_seg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13915">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01177">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atos-like conserved" evidence="2">
        <location>
            <begin position="345"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="790" mass="85946" checksum="746D4ECB1141A6A9" modified="2013-09-18" version="1">MPIFQADLDNHDSIEPAAAPIELQIPPPAPTLRRLSEESIRTDLCEGPIFESPPQSSTNSPERTECAENGISDRASLIERLKRAQSPTWIPNRHFDSIIQHHAPPPPPPPPETKRPQAPSEPSLLAPAQITPEKNDSQPDFDNRLRDGLSIERPRSALHSGNFTEEEAVAKDRAAPKSRYPAPAETSWIATSPPRHYTPFQHDKGIPFTGSAESFRSTTSPLSSSLSSSFVYKPPTSPLVQAQSSEEHDMSLPRDGFGYTGNSRYMPNSASSSPWMSPSPRYSLPQRVPSYRREAFPYQAHQPRRSLTSTPSFMQAGASPPTPALLRPRRSSLVVESSPLQHASMVGSYEESILRGRMSTTPSKPLDFVAQIGVLGKGKCKSSLKCPPHVTLSFPAVYYSYSSTSHGRSNTDDGPSPYVGQIDLENGLPNPDDEHRAKKKAQSRFADRKPSEDVMDIGLDDQGSEQISRRNSRASRRSGSGSAKAPPGGSYRIPEKGQIQIIVKNPNKTAVKLFLIPYDLTGMEPGTKTFVRQRSYSAGPIIENAPAASEVNASDRPILRYLAHLHICCPAKGRYYLYKSIRIVFANRVPDGKEKLRNETTWPEPRYTPYKPIRLMHPPLPTHSGPGAMLAAEKALRRRSVGIFPGPSSQAFDAMDSMFRVNDSPTGSSAAGNTLPLDPIPFCLPGRVRTSSDVSNSTGTTAALGNEMRSPGSSQASRPSTKDSTNGSPSGPALYEKLNKGEPGYGGNAFALNRSGSLGGAEGLLSQRLRSLGVKQPSPPETPNRDDMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNS8</accession>
    <name>S0DNS8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein PTH11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426151.1">
        <property type="nucleotide sequence ID" value="XM_023571927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNS8"/>
    <dbReference type="STRING" id="1279085.S0DNS8"/>
    <dbReference type="GeneID" id="35398230"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04749"/>
    <dbReference type="HOGENOM" id="CLU_019101_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="509" mass="56977" checksum="55CB08C4E5F4982F" modified="2013-09-18" version="1">MALYSEPPTLREFKFDKPTLLVCWWATSFCTLIILLRLAGRFIRTERLFTEDRVAALALIPLYARMACVHFILIYGTNNAQFDSVELTDLQLRQKAIGSGLVLASRIFYAATLWVLKFAVLEFLHRLTRATWERSWQTSLYVIRIILVATFIAVVISDFVECRPYSHYWQVVPDPGGQCRQGYVQLLTMAVCNVVTDLLLVIFPIPIIVTSGMTIKRKIQLVLLFSLSLSVVGVTLYRVPHIIDDHGRQQYRSLLASVELLFATAAANSLVLGSFVRDRGLKKQKFRRSSVAESLDPSLNLRRPTLHRHWGSDEDLVRDVGMTVDPELQDQPDNSSENGALQYTPAPLLRKLDQDLERWQFPQRQRSNAEHSDDSLIQHDPLSQSKSENGIAPRRVSFFDVGGLLDVPPESSGSLRANSRASSKEDSTLSHSPPAPSLPAGSGGFRRGSTALLQDLGGLFGPMNSRSSRSRSKPRGTELQPIPQSRQESRYDLQGPPVAELRDPGGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPH5</accession>
    <name>S0DPH5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426422.1">
        <property type="nucleotide sequence ID" value="XM_023572267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPH5"/>
    <dbReference type="STRING" id="1279085.S0DPH5"/>
    <dbReference type="GeneID" id="35397928"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04447"/>
    <dbReference type="HOGENOM" id="CLU_005936_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="80372" checksum="2D8DFE2FD62C4F7B" modified="2013-09-18" version="1">MGRKPNPLILEYFVRGPKLNDNSNRYPHTCKQCGENFPKGRIDSLTTHITKKCPAISESDRMRACLELHGITNARAPVDRPPPEAQPNGQPADVPNLPQGWSALETLAEASRQVDLNENNRAQSVQAGVVDPADPANAQHVPDRFELHEQFTLDNPPVSYENRSQQGNRGNGPLEPDLQGALLTTNVLGAIQQPLPGTELSPEERLQALLPNSVASPDVSNISVAVAATARLNPSLLDPQLVHETGTSTTPPSMDIPTPIEASPSAVTAPDSGISQPWGEMTYLATASPVPLLHEHPPTPIQMSRGGVRMDTSDGQLNGRPRHARSRFTAARRKEVQEVRKIGACIRCRILRKNCGKGTPCDTCRKVLAPRVWRTGCVRTRLQEQLDLYSAGVQVVLSQNRINLLKNQLNMTHDGTMIEVSHFPETGKVILLEALVALLEPSESLAESRGSKDSFFQVIMIDQDKEDVPGKVEAYMRDVFQLFIDREPSKFMRVTLSLALQQLQESEDDLLRKSLELWGLVESIDRERQWNVIERPADKNEEPRRIQEAKSENDADIYTTLCMQLNAAAERKANNTSKALLSGMHRVLQDSKVKVNFKMYLTAVIFLNCLEKSTWAFKAWEQDHLRPGWPLERDPGVFTQQGGNLAGLLKMLLAIRKALPQTLRSDTGKLITSEQDPVIGTYFQSIDLDYDTILARQDGSPFSPADSRSLEMILCSHLLITNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPN6</accession>
    <name>S0DPN6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04258</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426595.1">
        <property type="nucleotide sequence ID" value="XM_023572478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPN6"/>
    <dbReference type="STRING" id="1279085.S0DPN6"/>
    <dbReference type="GeneID" id="35397739"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04258"/>
    <dbReference type="HOGENOM" id="CLU_070610_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="118"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT64514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="228" mass="25139" checksum="9FBA4D5A7E4C3B98" modified="2013-09-18" version="1">MATAIDQAPGNGNLAASASHPGGSETQTTATEVFETPRTSFDHDPHDSSNHGRHETESSTVSPSSITSPPYWLNTRAGHQRTISNMSTDSVLPAGAITLRDNEASEFDDRNSACWAKSVEIVSYTIVNGSATNIGAFVVWNIRVEALNGSYMNIRKRYSEFDDFRYRLVQTFPGFEAAVPALPPKSVISKFRPRFLEKRRAGLQYFLNCILLNPEFSGSPVLKEFLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ66</accession>
    <name>S0DQ66_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable alpha-glucoside transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_04212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426637.1">
        <property type="nucleotide sequence ID" value="XM_023572531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ66"/>
    <dbReference type="GeneID" id="35397693"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04212"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="63"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT64556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="549" mass="61653" checksum="2817002DAC4CC046" modified="2013-09-18" version="1">MVAEKHSGEIQPHVESTDAGLDHLKNVDLHDKALANEALEATADEHSFTVWQGFKTYKRAAFWSILISTTVIMEGYDVTLLGSFYGYPRFREKYGEYLDKENGHQISANWQQRFNCLGALANIIGALLNGWATSRWGHRKVLISGLFWLSAFIFVVFFAPNIEVLLVGQFLCNIPWGIFATTGPAYAAEVTPLAIRGYLTAYVNLCWCIGQFISAGVLKGLVDNPTPWSYRIPFAIQWVWPIPLAIAAYMAPESPWHLVRTNQLEKAKVSLERLSEPEHNINYENAVALMVHTNKLEIEERSGTSYWDCFRGSNLRRTEIACMGFLSQITNGGALCYSGSFFFQQTGIGPSASYGIALGGTGIAFIGTIISWFYIYKFGRRTIWLSGFSFLVVLLWLIGFLALPKQTLSLAWAQSILCVVWLGAYSMSVGPIIYTIVAEVGSTRLRTQTIVLARSTYYVGNIICGGLIQPEMLSPGSWNLKGKTAFFWAGLATLTLTWGYFRMFETKDRTFGEMDYMFQKGIPARKSAKYHINEDEVFMAHEKPEAEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQA4</accession>
    <name>S0DQA4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424829.1">
        <property type="nucleotide sequence ID" value="XM_023572496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQA4"/>
    <dbReference type="STRING" id="1279085.S0DQA4"/>
    <dbReference type="GeneID" id="35394153"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00668"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_3_1"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="54"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT62748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="527" mass="56515" checksum="C051C54BB2CE4151" modified="2013-09-18" version="1">MALLQRLAAPSRGALRQSPVISLMLTRRASNVAPPKLKDPSLLKQDVCYVNGEWVKAGSGKTFEVHDPSTGKLIGTCPEFNSKDTQLAISAAADAFPSFRTKTGRERSKLLRAWYDQMAANAEDIAKIITWENGKPIADAKGETTYAANFLEWFSEEAPRVYGDTIPSSVPGNRVWTIKEPVGVCGLITPWNFPAAMITRKIGPALAAGCTVVAKSPAETPFTSLALAELAHRAGIPKGVVNVVTSHENTPELGELLTSDPTIRKVSFTGSTGVGKLLMKQSSGTLKKLSMELGGNAPFIVFDDADVDAAVAGAIASKFRSSGQTCVCANRIYVQRGIYDEFVSKFTEKVKSFSVGNGFDQGVTHGPLIHDRAIEKVEAHVKDAEKKGGKITIGGKRLNDLGSNFYAPTVIRDMTPEMDMASQETFGPVAGLFPFETEDEVVKMANNTEVGLAGYFFSRDIERVHRIAESLEVGMVGVNTGIISDAAAPFGGVKESGFGREGSLYGIGEYQITKMITYGGMGKPLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQI0</accession>
    <name>S0DQI0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426757.1">
        <property type="nucleotide sequence ID" value="XM_023572676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQI0"/>
    <dbReference type="STRING" id="1279085.S0DQI0"/>
    <dbReference type="GeneID" id="35397562"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04081"/>
    <dbReference type="HOGENOM" id="CLU_062276_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT64676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="270" mass="29949" checksum="AEE8D151C6E89E88" modified="2013-09-18" version="1">MVKPLTFKGDKKAKKRKRTDPEKSQRDGVDDEAGQLQKTGEEAENDDSWVSAEAATDVVGPIMIVLPTDEPSALACDTTGKVFAIPIENIVDGNPATAEPHDVRQVWVANRVAGTESFRFKGHHGRYLSCDKIGLLSATSEAVSPLESFNVIPTGDTPGTFQLQTLRDTFLTIKAPSKASSKAVDVRGDADAISFDTTFRIRMQARFKPKLRASKEEKALAKISRRELEEAAGRRLDEDEVRRLKRARREGDYHEALLEIKVKSKHDKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQK2</accession>
    <name>S0DQK2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426782.1">
        <property type="nucleotide sequence ID" value="XM_023572705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQK2"/>
    <dbReference type="STRING" id="1279085.S0DQK2"/>
    <dbReference type="GeneID" id="35397535"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04054"/>
    <dbReference type="HOGENOM" id="CLU_012538_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="580" mass="65282" checksum="DE6281455DF964C5" modified="2013-09-18" version="1">MATPYQALACPVCSKPLSARQNECPFCQKSFRRADVARRHARSCNARQGRPLPPQAKPGRKLRACDNCSRLKTSCNSELPCQRCSARGIDCIYSSLCHDPAHRASSKPREVSKGDSPSFSFLLQASNPTNASMDAIVAREPERTSEMPAWKHRETVGWSSGTIDPRFLLFDLPDMLVDEPQDYEYTENNMLQFSGIFRPSTESADALSTQIVALSNILQELTTNKPRLKDGLDQSCQRGFFTSSHFQNVLIFIFRRRHYHQDTIHWSTFDPEKVSLHLLLAVVLTGTVYIQCLNQSSPSYINASLLELAEKYIYKELKELSSQGFSPVTSQHMLEICQAAVLMNTLEGSENHNESRRRIASKRIPTLVGVLRKANMMSLKHEPGKSWGDFVHRETCIRVAAWTFMNDSLLALFCNHPPIITSKEMTGDLPCSTGIWEADSSMAFQERAQHGLARSYPSSCSEAIAGFLAGEWTPAIRDSFGKLDHSDLFYLSSGLGHHIFHYRTSAASCDHSKMLLRALDRWDSLWMDAYQPFSRRTIEVIQSGEAKDSAYLQEIGCYDTAVFHEFVQKYGQMSPGTAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRT5</accession>
    <name>S0DRT5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to SNF5-component of SWI/SNF transcription activator complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427237.1">
        <property type="nucleotide sequence ID" value="XM_023572573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRT5"/>
    <dbReference type="STRING" id="1279085.S0DRT5"/>
    <dbReference type="GeneID" id="35397654"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04173"/>
    <dbReference type="HOGENOM" id="CLU_004908_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="719"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="895" mass="100653" checksum="06C7463265904115" modified="2013-09-18" version="1">MTSSRPRGDVGGSFASRRGHSSQLSISDPSHHVTEAIGTLYGDEDDSGSEGGRPLSVNRPLSFIGGPTPYQESLPRPPPDDRFLSVDTRRGLKRTDSESSAGETSPVNGDPTKRPQPLSQGQRSNSFEQGPKSPLSPTLSLRDVQADSQFSLTNIDNPNDIAQELSNLQALRRLSMDVGNNKDPDMPPMSLMAMPTIAPSGDDDENDPSRLLWVPARVHPELAPGEFKSFLENRVHSIRRRSGDSFLSADTDTSEGDSGAGGLRRKKSMLSRQIDNTEGGALGYVDGAERLDRRRSRGHSHELSLEELVKDPTKAVQKFAQESQVAPSGPESNADDMPILPAAPGMGLRRSTRTTYRKGGSLRTGPLARRSGHRQQPSEDSNFAPLEAPPGHGLTRVQSEPVADNYSQQNRTVKRSHKFSQESVEDFDSYDETRQGANNSELKRAETFQDQLSIRSSPSLPTIETSTYQDARDQHEQKFPKRSSSQNAKTHPVSQRMSEPEPVIEEEPSRPSRRSIGRQPASQSPQQQHTSRSSYPQSQSLNDNLAANPSLLPGSGSSRTDSLTFIPTLNQDERKPEKKSKKDRDDDSSSTKSSGSAWKWFKSTSDDKEKKKEESKKSKTKSLGERVQDNVRLDVIQTSIDKNAPKGRESLVLDRDNVESKLQEERKKESHRKSDSKRDKDGSIFSSIFGGSKKKEEKERNAKKTQHLKVPEEPVYKPLVPDVDYHWTRFPLLEERAIYRMAHIKLANPRRPLLSQVLLSNFMYSYLAIVQAMHPQMNVPISPQQKRLEEEARRKQQEQEYLAQQQMREEQDAQEAMDQYDFDYHRAAVQYGESGNGEVDYVDDAQIYEDEHGTDHHQDYGYDDPEGYGPGSKEYYHQYHDNENDRRQDGREDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRW1</accession>
    <name>S0DRW1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to small s protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427262.1">
        <property type="nucleotide sequence ID" value="XM_023573795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRW1"/>
    <dbReference type="GeneID" id="35395585"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02102"/>
    <dbReference type="HOGENOM" id="CLU_419796_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7791" evidence="1">
        <location>
            <begin position="290"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="653" mass="75042" checksum="F1B5E4710C9291E5" modified="2013-09-18" version="1">MMKWLSRQSQIQQALKYWAGGSILLRCHHFFSVEGGNFLQKPREGMLRSIIVQLLRAQPSLAAVVYPELFTPERLSAPIDSAKFPMNHLSWSGLLNAVQKIIAHAGKSDWKICMFIDGLDEYRNIKREDRYTEAELDMLNDGDDSGNYGRDVETPISTDQREIVELLLAILKPWVRLCMSSRELNIFESTLAKFPRLRMQEHNKADILKYTWSKLSRPEWDQVDKTSFVQEVVDMSCGVFLWVRLVVDILIDSRSNGDTAKQLREELRKTPVQLCGPKGLYMKMMSMVRHDYLQESARIFQLVLGANNPLDLETAYFALSFFEGDKPNFQPALSMETSVKESLDMSDVNAAFRRKIKSRCGGLLDEDSQHLKFMHNTAREFIIRPSTWKRLERIFDEENFEVPHALLAGLIMRVKSGPEYLRLRPQYEHVPDHYAFVTDAMHFAYIVDGKTRYKPEYVELVDTLDQAMTKMVEAAYPQNCRCGCRCAWPTFEPMESGACDIYDTFFCYAARGGLSTYLDAKLSGMSLPITMAQKVLAHYSKPVRGGIPMLCFSGTRYIPINYPYGDPNVARVLLKYGADPKLVWESFLRQGYYCFGRGSNGIYQYFRAHVDMQAQDQRRWIDVLKLFLEHGADPTVVVKRTYLMTDASSGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS07</accession>
    <name>S0DS07_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable nuclease S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427312.1">
        <property type="nucleotide sequence ID" value="XM_023573858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS07"/>
    <dbReference type="STRING" id="1279085.S0DS07"/>
    <dbReference type="GeneID" id="35395642"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02160"/>
    <dbReference type="HOGENOM" id="CLU_044365_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485225" evidence="8">
        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT65231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="337" mass="36103" checksum="90F839EBB1DB1321" modified="2013-09-18" version="1">MMLKSLLLASGAIRAVHGWGVLGHATVAYIAQHFLDDDVATWAQGVLGDTSDSYLANIASWADTYRTTAAGKWSAPLHFIDAEDSPPTNCNVDYDRDCGSSGCSISAVANYTQRVGDSRLTKANKAEALKFLVHFLGDITQPLHDEAYEVGGNDIKVTFNGYSGDNLHSDWDTYMPEKLIGGHALTDAQSWANTLISDIVSGSYKSKAASWIADSDVTDPIGSATAWASDANAFVCTVVMPNGAAALQTGDLYPTYYNSVIPTIELQIAKGGYRLAHWLNSIYSAKIATRSTHKLNARKPLPDLMGRDLLPAARPLSRAKLAREAMSGSCCGSGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS69</accession>
    <name>S0DS69_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_01356</name>
        <name evidence="7" type="ORF">FFUJ_14432</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
            <strain evidence="7">IMI 58289</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="0" first="0" last="0">
            <title>Deciphering the Cryptic Genome: Genome-wide Analyses of the Rice Pathogen Fusarium fujikuroi Reveal Complex Regulation of Secondary Metabolism and Novel Metabolites .</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M.K."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J."/>
                <person name="Huss K."/>
                <person name="Michielse C."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 58289</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2013-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="MIPS"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 58289</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425494.1">
        <property type="nucleotide sequence ID" value="XM_023579639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS69"/>
    <dbReference type="STRING" id="1279085.S0DS69"/>
    <dbReference type="GeneID" id="35394841"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01356"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14432"/>
    <dbReference type="HOGENOM" id="CLU_013929_20_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT63413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT65092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="524" mass="59208" checksum="D70D3A55A82D581C" modified="2013-09-18" version="1">MPSFTEKDMSAALQMVADGMSVNKAAEACGINRSTLQGRIKGSATPREAQKPRQKLSDTQEKSLRDWIVIQADLGCPVSHQQVREFASKIAVRNGFPEGVGKNWLQGFLGRNPDIRTLKGKKIDSDRYHGASSELIKAFFMLLMMPAIRLVKQGNRYNVDEVGMMEGIGMNGLFLGHQSKKSVLIRQPGSRAWITILECISATGKVLRPTVIFKGKTVQQQHFPENLDFLEDWEFACSDKGWTSNKLALVWLRKVFIPSTQPEKKNEPRLLILDGHGSHVTEDFLWECYNNNIYLLFLPAHASHVLQPLDVAVFGPLKRAYRHLLLDLTSVSDDSHVGKITFLYTYDKARREAITKSNAIAGFKATGLWPVNLAKVLMNPMVTETPSPAVTANSPAKEQDLSLLKTPRSSVQLRQALGQVPASATQDPTVRLLFRKIGSQLDRHNFDIERQNREISVLQRENEENRPKRRKKVVYNPNAEFAKIPAIKKAREQMWKTLQPERTANKVKKLKLEDLCTNFHINIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSU8</accession>
    <name>S0DSU8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_02598</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427720.1">
        <property type="nucleotide sequence ID" value="XM_023574348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSU8"/>
    <dbReference type="STRING" id="1279085.S0DSU8"/>
    <dbReference type="GeneID" id="35396080"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02598"/>
    <dbReference type="HOGENOM" id="CLU_000288_2_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="10"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="345"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT65639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="626" mass="69593" checksum="AD6A4E42394BE11C" modified="2013-09-18" version="1">MADEGVAEHYQVLEELGRGSFGVVYKGIEKATGETVAIKHIDLESNDDDIQDIQAEIAVLSTCASSYVTQYKGSFLRGHKLWIVMEYLGGGSCLDLLKPANFSETHIAIVCRELLLGIQYLHNEGKIHRDIKAANVLLSETGKVKLADFGVAAQLTNIKSQRNTFVGTPFWMAPEVIQQDGYSFKADIWSLGITAMEMANGEPPLCHIHPMKVLFHIPKNPAPRLEGNFSKDFKDFIAQCLTKDYDRRPSAKDLLRHRFIRNAGKVEALQELIARRQMWDANQNRQKHPIYYQETLQSMAPKDEQQEWVFDTVKSVAPPPKRPTIKQHRKPSSIWNAEEAMKKLDVKDGPLGGTSPAPGTVRKSTVRRAPSVAQETSTRPGSPRGSIAPKRPLQPDMSFGNSGSTMRLFRRVPSDGSNGSQGNRPVSPDDVFRDENQPRPTTSPVEPYGKEAVLGRRLYNKAVEPSLAELHAQTSAMQKREALAKLSDAFAALDAVDPEGAYHLMTSMVSSISQDNKLSATILRQPAQKTPGDGTPQGTVIVKNTTPASSPTKLVMASNNPHLRSHRRRHADTPTMYEKNFDPEKLATESKYPGQEARSGMEHCKQLSDVLYSRWVDGLRIRWPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU49</accession>
    <name>S0DU49_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to VPS54-subunit of VP51-54 complex, required for protein sorting at the yeast late Golgi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_03091</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428175.1">
        <property type="nucleotide sequence ID" value="XM_023574900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU49"/>
    <dbReference type="STRING" id="1279085.S0DU49"/>
    <dbReference type="GeneID" id="35396573"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03091"/>
    <dbReference type="HOGENOM" id="CLU_003094_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="10">
        <location>
            <begin position="289"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="9">
        <location>
            <begin position="822"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1068"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT66094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1106" mass="121822" checksum="0DA11E9E1490D8D2" modified="2013-09-18" version="1">MFSPSSPNATKSADNLAALSPIGRGELPFHSNSHRHAQMHPHPSSRRGSTASSIHSVGGILDSAPSNLAASVYESSQNAISTLLQPPIVRTGLQPHTSAPASTAHKPPTARDIPPVTLTNITKVDTEEFKPYLSQIGSLYEQLQRLKDSDEDVNKEQRTGRQDTTTESSGDGYLRPGPKPRPTRKGSTASLSSMNSNDGHSPVRRPSAGFIRRSTHGPPPLSTIPTVYFDDEFHLENPRTFDIVSERSEVIRPANANDGQSSLNGSAAAPRKALATNAILQEKLSWYMDTIEVHLINSISAASTTFFTALGSLKELHSEAAESVGRIKTLRKELKALDEEIATRGLHIVYQRRRQENLRQLNDAVLQLRQIADGLANCETLVDEGEVDKALANIDSLEKLIAGERDATTANEPEIQLRDLRSASALQGIHADLTALRSRIGKAYETNFQNILIRDLRRHVESVSSQEILLRWSNAASRSKGSHARSPSVFPTYLTNTDELKTELLPNMIGLHRAKHIAEATVAYRESVLREIRNLIRRPLPSSTDDDNESMMSVSTASGGRHLSNQEKSSILARNLRSLDPEDGEDLLIKIYIGVTETLRRLTTQVKVLLEITSSLTESPQGEGLMSPTVRSPISSPRPDRFPSNPMNSATFEVQEELHKSLDVTNLLGQAVDVAIEKIVKVLKVRAEQTAQLPLTLFLRYFTLNLYFATECESISGRSGTSLKNVVNGHIKDFVQRNRDAEMQKLAQGMESDQWNAKDFTEKDTELLNTILGSSTHDPHEWTDSTKIWVPSSELEPVNEDDAIETNGTGKEKTRTATIDSETFMLPKSAILCLDGIAKFSHLISGIPSMTVDIATSLIAYLQLFNSRCTQLILGAGATRSAGLKNITTKHLALASQALSFTATLIPHVREFVRRHAGSGASVSNLMGEFDKIRRLLQEHQDSIFQKLVEIMGGRAAIHSRTMKTIDWEADGDKGVHSYMETLAKETTTLHRVLTKHLPETSIQMIMLPVFASYRDQLGSSFREADPKTETGLKSMNNDIEFLTTKLGKLDGFGETGEYLQKIIKSKQVKAVEQVTETPADEKGDDESKESEAVPASESTAEKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUX4</accession>
    <name>S0DUX4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426409.1">
        <property type="nucleotide sequence ID" value="XM_023572248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUX4"/>
    <dbReference type="GeneID" id="35397944"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04463"/>
    <dbReference type="HOGENOM" id="CLU_010595_7_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="37429" checksum="BAE014C327D061E1" modified="2013-09-18" version="1">MDHRDPEEDPTSDYEDSIATSEFTSVNTRELYSYEHGRRYQGFLCGRYGLPNDDAEQVREGLKHKLYLDYLLDGKLFLAPIGDNPQKIVDLGTGVGMWAQDVAENFPSARVIGCDLSPIQPHWTPPNVEFRVEDLEDENRPWTRIYEDADLIHVRALLQTLRKPRQLLERAFEKLKPGAWIEIHEIVPFVFSVDGTAGDDHPMNQFYRLVEGPFTTIYGWNLRFPFQIVEALRDVGFINVNERHSYTPVGRWHQEAKMREMGIFTQNILEEWVTAMLGRPDIMGVTEEEAYELGHSVFETFNNTRIHAQLDWIDCWAQKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV87</accession>
    <name>S0DV87_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_03406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428461.1">
        <property type="nucleotide sequence ID" value="XM_023575250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV87"/>
    <dbReference type="GeneID" id="35396888"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03406"/>
    <dbReference type="HOGENOM" id="CLU_044876_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT66380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="317" mass="34707" checksum="11B54492A6392054" modified="2013-09-18" version="1">MVTVAVAGGTGKVGRTLVEAIVAAGEHKVVILSREENKILEEEIGAPVLAVDIHNIDALTQLFEKHNIHTVISTLGMNGPEPIEIDIIRASEASQATKRFISSDWGLPHTEEHAAQANSANNKLRAQDELRKTNLEWTSIHIGFFLDFWGSPKSAAKSNLHTPSTFVDIKHRAAAIPGSGDVPVTFTYSRDVANFVAALLNLEKWDEATYIIGDKVTFNELVKIAEEATGDKFSVVYDSVKTLEKGELSELPGHEAMFANIPAPKAVMKKVMSAYGLWAETGGFNLDESKALNKVFPDIKTITVREFLEDAWGNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV93</accession>
    <name>S0DV93_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_03518</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428565.1">
        <property type="nucleotide sequence ID" value="XM_023575375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV93"/>
    <dbReference type="STRING" id="1279085.S0DV93"/>
    <dbReference type="GeneID" id="35397000"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03518"/>
    <dbReference type="HOGENOM" id="CLU_022880_1_0_1"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="15">
        <location>
            <begin position="415"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="96"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT66484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="623" mass="67670" checksum="9A6935BED10619D6" modified="2013-09-18" version="1">MNPYFPPTPDAEKWSDPNYYTRPAPVAPPTPSPPPEYSAYRPEFGAGLAPPPPPRPLRPVRSATNLTGAHAPQQSGFLDPRGNYQVDFVVDEIPSPTSLSPAPLSPAPSNEIRRVKSSSALSARLDAQEDKPKDSSKWKAALGEAQYFAGGLISHPAESNKHFSIIRHSHALIWYRGPATSVPITILSDEPLPPTRTVWLQQKGYSGNMGMTLKAMMRTTGTWIDVTSATKTGVEHIAEAEERGIQRDFKRFVKKASGRMKKHLPRETHIIRIPAAATDGYFRLVLCSNADGKKVLCGSPVFRIASTSTDVSTVRGSSLSTMPLEMGIKVASTIGSQVAKKYTGVAGAVVEQGAKRLTPANATIKKVATKAYHGSGIGNAVSESWKNGKAGRYDPLISGEAMEPLTILGSDEGPEAPFPFKFAGKVVRGTGIATRELGIPTANLSEVGDEVKMRMGGVFAAWARVLPPKESEDFDDDWHEAIVTIAPLRNAPPGVVLRNKVTVHILHDFSDTLFFDLRMKIMLMGHLHPSSPNLSNEAFLEEHTRDVMTTTASLGRENWGPEVSVSAVRAVKSEKGFKERLGDATGMVQSQMDRIPKHWVGVRSEAGVLRDHVYGNGGLWVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVA2</accession>
    <name>S0DVA2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427408.1">
        <property type="nucleotide sequence ID" value="XM_023573971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVA2"/>
    <dbReference type="GeneID" id="35395744"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02262"/>
    <dbReference type="HOGENOM" id="CLU_009290_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT65327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="896" mass="99837" checksum="CDAB5CD92FD78656" modified="2013-09-18" version="1">MAAFGRLQAALAAATNEVTVAAANINFDFTLVKYEAPKEFRPIEGYLTTTRKQDAETGKSHVVARRLGALFSGICPDSPNLIRAYGARVSEISKTATQKESQEYSKSIFASYVGVDATSIWAAATSSTTAIHVHLLACMLAELWDASEATSIWAELVEERRKDIAHRLEQGEALHFGLASAAAQQEITRDQLASWDASARAWIQTGKSVMSKNDSQLRLILKNVYFAINPSEAPFVSVVDAWKLAIETTEKLILGIPQEAQNGAAILGLSAWHIYPDIHIYGNKNIKVTMNDELVRAGGILSLASCPSQRTESRGVYWSLCLSHLTFYGPPVKRNQSLEKEHRRIPFDHLLHATVGAILSRWRVHSSDLVDGINILIAILKIINVANQSLYPIMSLFSNAAKQCLDDEQAWSYMLYGKRRSGFIKNPDLEVTGATKPFFGLSDITLLLSCMAKSEDRISLLQRQANRVDLSEQEVIIFDLPSLTAHEVESGHTHSFNTRPKRRKTTAKKMEYDIIGTQLFRGNGKNVSVFDFWIGDSSSTAIYKKQVKNALQTDPPTTTFEDLKWCFNNSLISSNTFLKLVHKQDTIMNTLICLYYAYELLKTLPHLLVRIQCLEASLLYAQWTKPGHLYYPHLSVSSFENFYLETVPKYAGLIQFQILAHLIGGYDIHHSAIPSHIIGLSFQDSIIVPASLVHDPGEKVPHLIRILGNIGRPGLTLLIAPANPMLAPLDEGTWRISNLNRFNGKTEDMLSTTSLHLSFTDWSQPLNSGGVSGSRDAVISIKDSGQWVGDVDILKALQSDMIHLARLDPFCSHARGALPQNHMHSIECWNELRDCPEEQSVIRASGNWVARLAAVSYLAQKMDTKDMRSSRIFICPDNVCWACREAESNMDDICIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX81</accession>
    <name>S0DX81_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_13377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429265.1">
        <property type="nucleotide sequence ID" value="XM_023576056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX81"/>
    <dbReference type="STRING" id="1279085.S0DX81"/>
    <dbReference type="GeneID" id="35406831"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13377"/>
    <dbReference type="HOGENOM" id="CLU_291029_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clr5" evidence="4">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="632"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117018" checksum="2BE3A7402F041D46" modified="2013-09-18" version="1">MSRAPKISEAIWERHKSIIRTLYIDEDNSPEKVSEILRDNYGFTASRHQIIRRLARWKFKKYTTKEEWVYTSLQIRRRKEQDRKKTEIVLNGKSISEKKLSKALGRYVGPWDFGPECQRIRPCEDLTTIAIHTPKEDSGVIPYSTPWFKFWTLAEETVFTSAAIALARPKSHNNQESLDKIMKFMSSDEQQFTELPSLLSHLATALPLFHENQRHTVQEDCDSLLLQWIFYAGSNKLVSVECTHILLKWAIDNNYLRLIKDAIALGGLTVQAASRCLLPSAVEIGDMDLLQLLLQTARGPSFSSRYLDRALAVAINNIDGPMVDVLLKNGANTTRSSLSDEQRMRQALKLNNSDKIVRSLLESGADIRGMSITHSILLYARSTASAKLLLDAGAPVNFAGAMRFTPIQQAALRNDLDMVTLLLGAGADPNLVCGDARDLLLRNNCVAENGHIPYGISLALISPLMFAMGHHNFDMARCLLNAGATIDWPIASHPKGENSRLCRIFQWNTVHVHMLRWWRVARSWKDALPQYPGKVAAGKICEIFEALSQPAVNLYSFAYDWHLDGTALQAAVEINDYELVRTLTHDRVDVNKTPCSDPVLPALQTASLNGNTSLFRLLVQRGGDIHAQTAARGLTCLQAAAMLGSQELVELLLKMGARVDDYQRGNNTTVLQGAVISGSIGAVRTVLHAGADVNDSRGVCSPLYHAAYGQDPEMCAFLLHRGALVDQENRDSPLIAAIFRGSHKMVKLLLEARGNPDSCTRLVHRKWSESGMPQIQYREEEDKNDVQLWTPLAAACYWSDIAMIELLLQYGAILHKGMKCLFSPVEASICRNDFSYDIFQFIIHLRVRDLGGLSWDDREALVSCAVPTNVPCEVVQQMVALDLLTEVSKGKTLVLAAEKGLLERVRILVRAGTDIHSDTANIGGTALKVACQKGHLDVAEYLLAEGMGCRLWYELPNHAARLSDALDAAEANGHFNLVALLLKYTAAFSDDKFIEFELRHRRALAAGRVDIAHLFLDHSIRQYSPRLPVTADISEGELVDATTREREDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXD3</accession>
    <name>S0DXD3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mso1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429315.1">
        <property type="nucleotide sequence ID" value="XM_023576114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXD3"/>
    <dbReference type="GeneID" id="35406884"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13430"/>
    <dbReference type="HOGENOM" id="CLU_061436_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mso1 N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="259" mass="26159" checksum="AE261C10B0CC796F" modified="2013-09-18" version="1">MASWYSNLVQKTSSQISSLRQNLLSSEQDGDSEDDTHVCRVLRGYYTEKGRPFPPWLPTDPKAPAQQPIQPVMTPQAGQRLGAPGQQHGGLSSLWDNGPQQPQQQAPQSLRAGSGRTPASLQPGGGGGDINRRPLPSQQRAGSYQSTGGQFGRPETASVPPGGASGGGGGGGGSAQDRLRQRLWGGGSRTTSPQAGSQGPFNPPGGNNGGGGGGGGGGGGGSGGYEDRFAPGGMYDQASGGGNAGLRRGGLPSGPRGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXM0</accession>
    <name>S0DXM0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_02152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427304.1">
        <property type="nucleotide sequence ID" value="XM_023573849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXM0"/>
    <dbReference type="GeneID" id="35395634"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02152"/>
    <dbReference type="HOGENOM" id="CLU_044876_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT65223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="307" mass="33685" checksum="F236CA4D989C7B97" modified="2013-09-18" version="1">MAIIAVAGGAGKLGRAIVEAIVEKGQDTVVVLAREAKELQGAKVIAVDYTDVDKLAATLNTNSIEIVISTINALDDVSAELNLIQAAEKSASTKRYIPSIYGIQYTEEIASYFPIARAKRGVIAALEATSTLEYTVVYNGFFADTWVLPKVKSYQSPFALVVDVANNFAAIPGSGDELVTFTHTFDIARFIAFLVGAAQWDKASYVIGDKVSWNQFVQYAEEAKGVKFTITHDSIEDLKAGRVTELPSHPQMYPFFPKQMLQGFCAAFGRMFAEGEFDLKPERTLNEAFPEVKARKIKDLLFEAWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY27</accession>
    <name>S0DY27_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-14 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429522.1">
        <property type="nucleotide sequence ID" value="XM_023576361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY27"/>
    <dbReference type="STRING" id="1279085.S0DY27"/>
    <dbReference type="GeneID" id="35407106"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13652"/>
    <dbReference type="HOGENOM" id="CLU_017137_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="57547" checksum="C604B43EBC966A37" modified="2013-09-18" version="1">MKFGHDFKETLRAQDFPAHWVDHAIPYSQLKKCLKKVARELHELGLDPETLRELLNPDETSPVALKYKLNGGADSHLRPKLTVQVHLQDGVPVDASLAPNTRDFLNKIAINLPQNQPAQVESATKSLEPDSVKDAAKTETVVESTSAPSAETVDALVGEVNDKLAIAVADEKTVKITEKPASNSEQTEPIAEPTDNGSTEVSATSPATGATEGTYEIIEVPLTFDAEFFEMLQSDVNNLDALQTEEEKTMTSEIVALGKEVEQVVKPKRFSKTDLARWRQIFELYLDAEIFFATHEQDHGERSSQVALRQLQWFQDQVAKQNLVKDFKLPESTAAFHRFINLNASLLKNMQFQELNKTAVAKILKKFDKRTALGVARKFPTIVHSDKLLAGTIARDVCAQMSQELVSKVPQLNDYLCPVCFSVAYLPVRLDCQHVFCIRCVIKIQRRKEKHCPLCRADVVLKASAMNLDYELQKYMKKYFAKEVKEKARANEIERGIEDYGPGYVHQECCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY30</accession>
    <name>S0DY30_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to ubiquitin-specific protease 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429540.1">
        <property type="nucleotide sequence ID" value="XM_023576383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY30"/>
    <dbReference type="STRING" id="1279085.S0DY30"/>
    <dbReference type="GeneID" id="35407126"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13672"/>
    <dbReference type="HOGENOM" id="CLU_008279_11_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02660">
        <property type="entry name" value="Peptidase_C19D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000127">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase Ubp8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="179"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="514" mass="58712" checksum="D3D92BA791BBF5D3" modified="2013-09-18" version="1">MSGRPTTPASPKNIKVKSPVPGSPMFGCEHVQLLLSKNQEVMNSSITHYKLILRNIFDATPIVPQTSTQEGRPVTTLTSNYLCLQCPMTVSEEDRLKHGTKKQHRFYVDSRSGCLYCQMCDDFVWDPTLEELRVRKIGTGSFSGRKRKHNELFSDSMKDDPRYITNNTTTASCRANGLRGIYNAGATCYQNVVLQSFLHNPLLRNFYLSDGHQSNDCQVPHCLSCAMDDMFQDFYALENTNGYTAANILSGFWISEKKAFENLVTTKEQDAHEFFQFLAEELHERNGDGKKPEIGSEHSCNCIMHQTFYGKMQTTTTCQNCSGQSNSIQSFLDLSLGLENVVQKKSKRTGQKKPSLTLQDCLDEEYIKYDKCEYRCNNCNGTQQAKRHTSIKRLPNVLSIQLKRFEYRHGRHDRAASKVDNEVKFPLQLNMLPYTNRVRNHESRESLELERSCTYDLLSVVVHVGEIDTGHYTSYCRVGDQWFKFNDHKVELASLSDVLGAQAYLLFYIIRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY72</accession>
    <name>S0DY72_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable MAK3-N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_13614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429486.1">
        <property type="nucleotide sequence ID" value="XM_023576319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY72"/>
    <dbReference type="STRING" id="1279085.S0DY72"/>
    <dbReference type="GeneID" id="35407068"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13614"/>
    <dbReference type="HOGENOM" id="CLU_013985_0_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="186" mass="21111" checksum="C860662AE8E23408" modified="2013-09-18" version="1">MAPTKIDNIPGELRYVQYEHALEAQYLPAIRALISKDLSEPYSIYVYRYFLCQWAHLCFMALNPVDASLIGVIVCKLEVHASHSNPTRRGYIAMLAVASDFRGHGIATTLVKKAIDAMTKRNADEIVLETEETNVAAMRLYEQLGFLRTKKLHRYYLNGNSAYRLVLPLKYIDLDASANDLEIIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYL8</accession>
    <name>S0DYL8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to HNM1-choline permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429750.1">
        <property type="nucleotide sequence ID" value="XM_023576607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYL8"/>
    <dbReference type="STRING" id="1279085.S0DYL8"/>
    <dbReference type="GeneID" id="35408029"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14649"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="555" mass="60716" checksum="1AF9CA18772B8655" modified="2013-09-18" version="1">MTNDVETNSALKRSDTTNEAIRDAEDLANFGHDQSLTRKFSMWSMFALAFSVLGTWSTFAQGIDSGLTSGGPIAILWGLVLVFVCNICVAVSLGEMCSSMPTALGQAYWISRLWPTKAGRFCSYLCAWINMTGWITLSASQIAFMGEFMLKMKVLFQPDWAGADKGWVLFLVYVGVTLAMTLFNVVACRKDIVLPWFNNFVGVSFASLFFIISLAMLISVGTKDNLHYQPASFVFGQWINQTGWPDGVTWFLGLIQAAYGLTAFDAAIHLVEEIPSPRKNIPRVIWLSVTIGAITGFIFMVVCLFCIVDMSIVTDPTTGLAFMDLLKQTVGLQGGTVLLTLFIVNGIGQGIGIVTTASRLTWGFARDGGLPWSGYFAKVDDFWRVPVRALWLQGGVMALIGVLYTFASTVLEAILSVSTIALTVSYGMPILCLLLVGRDKLPPGEFSLGRFGSVINWVSVVYCAVTTVFFFFPGAPNPSVSDMNYAIAVFGIMLVITLVFWVIKGRITYLETEEAQGNIIYAQRAERANYVDVDVRTKTDTEARRASQTGGPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZM5</accession>
    <name>S0DZM5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to HCM1-transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02919</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023574707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZM5"/>
    <dbReference type="STRING" id="1279085.S0DZM5"/>
    <dbReference type="GeneID" id="35396401"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02919"/>
    <dbReference type="HOGENOM" id="CLU_012536_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="212"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="212"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="661"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT65933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="770" mass="84504" checksum="73FDB61B4C604AB6" modified="2013-09-18" version="1">MGKHSRFPSSTGPLQIFQDDMPENVTPMTSHAPMPSASKQARRPLTSSTSNVVFNPPTASHNAHSPFKQRPSSASQIPLASAYGNKLNMVAMAPPSRRGHTTDSLQKKPYLSNFKTVPQKQSFDMAWDYGKENVHPQLFPAPPAIDSSVSNYCQKPNGKRALMEAAPIKEFRPAKKTKAEPVPATEPEAETEATTVIPPHDSFPPIVDDGNKPALSYADLIAMAIFRSPNRRLTLAQIYKWISDNYSFYSPTDAGWQNSIRHNLSLQKAFVKIERPKDDPGKGHYWVIKPGHEAQYLNKKPTRKSASTSENLHVISTRLEPSRPASAPTQEPTLPPPVPTCQPALPPLPASQATMSMPVDLSSDATIPVSDNLGPEDAADKADQDLSLDSYLYSPLPAAIHSSPPVSRHVDHRSNTPPPVSRNIASSVSRSHKRKFVLTDDSGYYSSFETSSATRPSQQFMLTSEADRPRNKSRGRAEEEIARIRKSSPFSPTKTRFYSAIPPVSSSPLRPAYDKQMLPPITPMVKLNPPARPPPSASPNTNLRLHRDAVRNMLQSPDRKGDAENIPYSPAFYLGNDFCPSNFGVSILSDGEFSMNQDLTGMGCLEDGTFPVMSSVEAGSPMKRPAKRTRLDRTVSASVLGDITNSAARKPIASAPLLRPPEQSMQFDTPSKAFEGLSSPSKMFQESPLRNQSTKFADFLNVSLDPNDWTSGAMMDQLDFARPDAGSITDMPELDIFKGFDKIGSTSQNNSRNPPRSNKPGLPRSYTTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZU5</accession>
    <name>S0DZU5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_14871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023576863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZU5"/>
    <dbReference type="STRING" id="1279085.S0DZU5"/>
    <dbReference type="ESTHER" id="gibf5-s0dzu5">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="35408249"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14871"/>
    <dbReference type="HOGENOM" id="CLU_006586_10_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005146076" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="30"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="229"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="586" mass="64340" checksum="258C27E30F7A6096" modified="2013-09-18" version="1">MASHLVVLLLSIHGVLASEGPVVDLGYAVYQGSLQEGSSVLYNFSNIRFGEPPIGDLRFAKPIVPKGRNVTVDKGEVGRICPQAMAAWEVYTLFTGPDFLSGKISTLTEEQRYALKEPSDLKIPIDPRETEDCLFLDVITPVETFENSAKRLAPVIFWLSGGGYTTGEKGWFDPAGLIKASYPSSPEGLVFVSANYRLGALGWLAGSKLDPGNDVNRPGTDDVLLMRSSETMVANAALYDQRLALEWIQENIHQFGGDPTRVTIMGESAGGLSFWSMEASFNTDWNLTGASIYHHLTAFGGKDERTLFQRAIPQSTGWVHIADDKLENDVVDKFLALAKVSDLEAARKLSTEDVQKANRLLISNSAWGTSTAGPFVDGLYVPENPDKLFAEGRHIQNVDLLIGFNEDEGLIFTSPESSDDAGYRKFLESTYSNASPETLDHIEKTLYPPVFDGSHGYTNQTDRASITKAESEFTCKYGYLQAAYGSRAKSYRFNVYPGLHGSEMHYTFYNGPDRNPEADEAIAVGFQELLTSFAVTGNATSLAAPQGVPVYGDERRMLYIGNEGFGIATDETVPERCKFWQSGIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0J9</accession>
    <name>S0E0J9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430250.1">
        <property type="nucleotide sequence ID" value="XM_023577134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0J9"/>
    <dbReference type="GeneID" id="35400414"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06937"/>
    <dbReference type="HOGENOM" id="CLU_973328_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="286" mass="32754" checksum="18F9044050E8A112" modified="2013-09-18" version="1">MTEMDLTFICGQRTSSLLGGPFAASLFRTTYAKHRGRGPMVIPAALPLDIPAIEEETLCLEIRLNGDGCSMLLETRSLGVVHAGLQAKRTEDPKKNPFSLRYRVTRPRLLFLWKGQRDVLKHTVSFAIYPEGVVLAPNHVPMVIGPQLSSFRPDFTSHQPAWSWAPIEHIRSIMVHEQDGRGFIGMMIHYDNGSQRFIGDFARADDDDDDIRYPISIEPIKHMYVERWPPSGQYTKMQVHFGSRWLRHSMDTELDEYVFVGELHFWYGPWMAPELRVLPSGSWQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0W5</accession>
    <name>S0E0W5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430385.1">
        <property type="nucleotide sequence ID" value="XM_023577292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0W5"/>
    <dbReference type="GeneID" id="35400557"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07080"/>
    <dbReference type="HOGENOM" id="CLU_110355_2_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="117" mass="13024" checksum="0D482C0D0A1F6191" modified="2013-09-18" version="1">MASSSVTVPPGKYEFLVVVHDKPNVREKRLEVRGTHFKNMVPNVENGSWKMGGAILNSVPKDDSVDSLDFAGSTLVCIAESVEEVREQLSNDIYATSGVWDMDKVQIYPFKAAFRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1S2</accession>
    <name>S0E1S2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430725.1">
        <property type="nucleotide sequence ID" value="XM_023577703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1S2"/>
    <dbReference type="STRING" id="1279085.S0E1S2"/>
    <dbReference type="GeneID" id="35400926"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07449"/>
    <dbReference type="HOGENOM" id="CLU_004835_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1152" mass="127713" checksum="D345996E1FD61180" modified="2013-09-18" version="1">MDPAPPDSKRPRLSSWPVGTPQQGVSLPHPHAHQLPPPPPPPPGALHHPPHPPPSPYQHYPPRPIEHSSAPPTPSHAAPAQPLHDTDRRHHEPEPYPPVQDYHRQQQQHQHPPQQHPQQQHPHPPPSPAHPAHHPYPPYGPRDPPIKRDPAEDQRRPNSTGHAPEGMSSTPHLPPTSLPPPPPPGAYPDNPPRHMNYEGAPSMPPTPGGYRAPSFPPPTPVPHQTPYEQHGGYPSTPHEPFYSVYSSSVPAKKKNTRASQACDSCRQLKAKCDETKPCKTCKEKGVECKYRDPVPKATDKAQADILEGLGSVQTSLNSIMTHLGRFDQRLIKMESLLPKHLATSALKTESSVEDEYKRAPASPYVANGASVDPYYNDAHRDHPSSEPMPLRMMAEDEMEVEPGPPVPPGEPAIPINHTTLAGLLLEWPSIRELTKHHVEREGVRYISEYPISQEQNRGVLIVYGRGEDSHPSRHVREPTDHGNLDMADDSSDMASPSPAADWGQLGGLSPPDQVEYKGGVLVDGNPDFSEPKVWAYVESFKENILNMHPIIQPKLLDYWVRHFLDNLPASQPRSAKPQTSKPTFAVGGGSSTPEAAGSKRKRSPGPDGSEPPTPAPQRIGRPDRSIHTALVLTVLALGKVCLHRDNVPDVVHPTEPLPHGSPALRNGAIPPSPNQGSPPGYSSHSHSSGLPSPKEQDRNIHSRRSSIHGTGAFRSGYSLKKNYEVIPGLEYFAYATDILGNHTGAYNNMKNVYANIFAGLYHGQLGRPMESFAFIHRASHKLQVIMRPSLDKMRRIKRNSEFIQETKYNQLALTFWTCLQLESDLIAEMQLPPSGLLSYEDDMPHPNMSLLEGFNQRILDSYPGQLYLRTHLNSIHRMFYAPEDPAKPGKDKFRNVGVVSDAVSGMHWVAPSFAFREDDPPADDILAARLRAKYWGAQVITYRPFIRQILQFSHSIKNHASSPNFPSVSSEFRQDITAPVIHPKARTHGDIDPQVVELAKKGIKALIESTRAFHGLGDRRPIITNIFGTAHAQWGNLLILSAAFRDPILHTYVDEELLRTLFHKTIQFLRQSATATSALRTDMHILEGLQRDLFSYDPRTNSSFSSGTSAPGYHTPRPVPMAAPPQMPHQMGDQGHPRSMPHHLQMNSSHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E271</accession>
    <name>S0E271_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polysaccharide pyruvyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430966.1">
        <property type="nucleotide sequence ID" value="XM_023577993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E271"/>
    <dbReference type="STRING" id="1279085.S0E271"/>
    <dbReference type="GeneID" id="35401188"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07711"/>
    <dbReference type="HOGENOM" id="CLU_045699_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide pyruvyl transferase" evidence="2">
        <location>
            <begin position="131"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="461" mass="51867" checksum="26657D981AE5046D" modified="2013-09-18" version="1">MLPAMNRFTRIALAVIAVLFVFAILVSYQAPESFKDHLPSADWHWPSKGDNVTIDEPPKPTDAAGAVGAGEEDTELDKDPNTDISYDLTRAPTPGCENIVNDLQQRLIHAYQKRFEGIRYANIWGYLETENKGDAAIWSAQQILLSILGIETMEACRFMYKDCDITKFRKKLEDHRPHSGIIMAGGGNFNDYYWEDQPSRMNMIENFLNVSIRAFPQSIYMTNPERIDKTKKAFTKHHDLQLAARDKPSYDWLMDNFGQTEGIQSDLVPDIAFMWGNRSDFRHNTKKTHDILILARKDAEISDGDSASIEFGEGKVDLGGSIGNVTYNKVDWKFTKTPSIDDDAQREEGKNQRAWAKSMAGFELLGSAHFVITDRLHGHILSTVIGVPHVLMDSKLGKNLNFHNTWTRDCGCTKITKSIDSAFDVARMYFEQEVKDGLRAVDPPKPKSVPTPTPQAEAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2Y9</accession>
    <name>S0E2Y9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-6OR heterokaryon incompatibility protein (Het-6OR allele)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430087.1">
        <property type="nucleotide sequence ID" value="XM_023576935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2Y9"/>
    <dbReference type="GeneID" id="35400236"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06759"/>
    <dbReference type="HOGENOM" id="CLU_004184_7_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="52"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="652" mass="74769" checksum="81052012BD9CD62E" modified="2013-09-18" version="1">MSQFQAFDYDSVELRTASTEIRLLDLYPSQGLVDSRLTGRLYATSIESPSPYIALSYVWGLGDKTQSIHIANLNDDEKHSIPITESLETALRHFRKPDEVITLWIDQICINQADNKEKGQQVAMMGRVYSSAAQVLVWLGPAQDGSDELMEAWQHIGQRAREFGLENYMNPQSYYLISALGRNKDPSDETAVSFQSLLASTVEAFTPLLKQMTLKRWFERPYFSRVWIIQEFCLCPDTIFVCGSRTIPVDFVKFAVLLLQTAIGNMPQGDYEHLQPREMPLERLSEVSSEPTARLFGCRSRHQKHKDDELYTLLRRLFVELETNATVHCDRIFALLGLAADAEKLGIQPNYEESTERILTQTARTLIEKSGRVDLLCYSQFPKLDELHLPSWVPDWRSNLSRSFYTINERMDKHLFAASGHDSVVEVVQDPSDNSDILGLRGYTVDVIEEVAEGDGWTDMSWDYERYLGYMAQIDELWQKSMCKSDSELTQLQKEEALWRVPIGDIYWTWEGDQQRAKPDVAKFHEQFLQELKLFGDMTRLAATGEDVSEKLLQWEEEHRGADTKHNYRESMRKMQGKRPFLTKVGYLGMGPMESRSGDVVVVFCGGRIPFVLRPLEGSSGRDEFLYVGEAYCDGIMDGEVTGKKKQIFWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E384</accession>
    <name>S0E384_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431351.1">
        <property type="nucleotide sequence ID" value="XM_023578132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E384"/>
    <dbReference type="GeneID" id="35401311"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07834"/>
    <dbReference type="HOGENOM" id="CLU_177972_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="85" mass="9102" checksum="8B309EECE1CB87CE" modified="2013-09-18" version="1">MAAIARPALAKPAAYPKALPVVVAVGSFALVASYVTSQLATTSAKFDRSFAKYNTPESEANRARTFDGAIENPRTSLFNILGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3C0</accession>
    <name>S0E3C0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable heterokaryon incompatibility Het-C protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429284.1">
        <property type="nucleotide sequence ID" value="XM_023576078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3C0"/>
    <dbReference type="STRING" id="1279085.S0E3C0"/>
    <dbReference type="GeneID" id="35406851"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13397"/>
    <dbReference type="HOGENOM" id="CLU_010063_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485259" evidence="2">
        <location>
            <begin position="29"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="778" mass="84249" checksum="56A49FC22933C009" modified="2013-09-18" version="1">MPSFSTPRGSWLLLIAVCLILLPGKAEAFGAGNIPSIAQVEGHNWRHGDIEDMLETIAFLHGKKWTSMLIKRTYFGNWLRDYSQAVDIGSLKGVNAETIRILVWVLSFMAHGYATGEFEVTSDRLGVYRPEEHIDNPLGYGDGVDARTFDKRLRGPVEKIETEIDSRTGMKNYIANENGNWATSAAYLRYSFARSIHYGRLYTSGSKKGNEDDLCEALRCLGQALHTMEDFSAHSNYCELALRELGYHSVFPHCGAHTEIHLHGKRVYPLVTGTFGAVDFLHSVIGEASDHFTQSEVDEVDVALKNAEGASNRSGGGGGGERSLLGGFLGIKSSPSDFIGLVSKLPGVGDGFAAQARDLKASSEAQEQRNMSYQQTRGDLSRDNANQVPGMSPDFDPVETARKIYPILEFRDKIVKAISRGISKVPGLEKLLEKISETLTAFILGLLAPFIRPIINQVSKVLKDGSSGVITASAKSQYEPWDNPQCSDPTHSMLSKDHFTNILNSCAGRIAATILQYTVPRVLYAWENTGVSVDEVVNDVLRAFHHPAARDDHIEIQRDMFKTVKKWADEHPRRHELAHLLSSDSVKNHKNHILNQVQGNSRSIGGGGCNHGTFGDMANAGHGKVAGSLWSQVKTRDLDSMEGKDGNPAAGYLSSSPAPPSQSSFEYGQNPNYAASNSGHSQQGGYGAPPPQPSYGGGYGGPPQPQYGAPPGQYGAPPPGQYGAPPPGQYGAPPPQQYGGLGYGAPQYPPYGQQGYGGPPPGQQPPGWGQYPGSRHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E400</accession>
    <name>S0E400_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ste12 interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431500.1">
        <property type="nucleotide sequence ID" value="XM_023577696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E400"/>
    <dbReference type="GeneID" id="35408284"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14918"/>
    <dbReference type="HOGENOM" id="CLU_180977_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7609" checksum="535394CE297E14E6" modified="2013-09-18" version="1">MTAHLCKQIYASWRQTRQPSPDLAPPTQTPSSMFGRPISRSPSPPAQRSERRPSNASDTEWHPNSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4A6</accession>
    <name>S0E4A6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to transcription factor BOM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429619.1">
        <property type="nucleotide sequence ID" value="XM_023576298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4A6"/>
    <dbReference type="STRING" id="1279085.S0E4A6"/>
    <dbReference type="GeneID" id="35407049"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13595"/>
    <dbReference type="HOGENOM" id="CLU_012196_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="7">
        <location>
            <begin position="249"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="789" mass="85914" checksum="55815A736B7FCAF4" modified="2013-09-18" version="1">MFRQRTSSQKPGDELLANFRQQFPDLAAASTSATAPGLSQTTGAENVPAVPLPDRNQNLTQDAFRDQDPTPRATNDPWRFTPSLLDPNSMSFANFANAPPGYYTPTPGGTNTLFHPQAGDLHTPTLGLGMGLNTPLSMPTSGDSLHPGPAQPVMDMSGFQTLQPHQFHHFNPFIQAPPPQPTFAPSTFVHQDTGYETMDQDGSPMDSDPSEERMSSIGAALHKTTPIMNMPTRQFSGGPISHPLPASAEKFRFHSTLNAPTAMIKHADEIPVTYLNKGQAYSLSVADTNATMPVAPGTKYRTFVRVSFEDEQQRQRPGVCWGLWKEGRGTNEAHQRGGKLQAVEYVEAGQPAEGDDKRTRVELESSSFDGFCVTWTPGINGPPEVNIAVRFNFLSTDFSHSKGVKGIPVRLCAKTHPVPCDPSQPAADANPEICYCKVKLFRDHGAERKLSNDVAHVKKSIDKLKQQIAQAESGLKDFGKRKRSSGAAKIGEPQRPGKVQKHKRTWSMSSASSAGGGGRATMEEDLHFKLQTLQDMFTSTRPVSVLFLRGEEPDDPDLHPVSLPGDISPLTKPGEGPNWQARSGRSSVAGSMISPSPSSLSLASQASGIGAGGQWKNFDSVAGGDISRKGSEQPTRIAKGDDDGSLSGWIEALGVDSSYRPPQERNPKPVACFYIQRRNPNEPGSSDYHRAIYLMQRSLQELNNRIAAKWGIDPARILRTIHSIQNGLEVEMDDDVVQELKEGQDMTLEVQEVTGPAVKREWEMAVDATEDIAESNDKATSGFVLRLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4F2</accession>
    <name>S0E4F2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="7">1.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_14513</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="7"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429664.1">
        <property type="nucleotide sequence ID" value="XM_023576456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4F2"/>
    <dbReference type="STRING" id="1279085.S0E4F2"/>
    <dbReference type="GeneID" id="35407894"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14513"/>
    <dbReference type="HOGENOM" id="CLU_003827_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000003">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
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        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
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        <property type="entry name" value="FPNCR"/>
    </dbReference>
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        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="670"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="781"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="122"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="125"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT67583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1051" mass="119745" checksum="F60E9A4BEADE4E19" modified="2013-09-18" version="1">MPHSKPWVVKVQAHPGSTAEEIRNEPDWVSGHQHRVGFRDRNNRLPGLTHKDDEYTEEVAREKQKYLAFQKRAQSGELINFRDLIENQKDFHLRHPENRSLGWRYVLNETEDWVKNKEQWPANIKKQEEENKKKEEEAKSDKKDDTPEQEHEWKRSSDKDKHHDAYAKNKENEEKKQENKSSEKPKLSDKYTPAEIALLRALEHEKKYIQHLRENNGKRKSPQHKNLTQISIDEQDQFSPDNWLPRSPDLIRLTGKHPLNAEAPLTQLYEAGLITPNELHYVRNHGPVPRILWEFHELEITYDGKTQTLSMDELKEFDTINIAVALACDGNRRKELNMIKKSKGFNWGAGGASCAYWKGPLLRDVLLANGVPEKPPGLGERRYWVNFEGTDDLSEGKYATCIPFEHAISPNNDVILAYEMNDVPLPPDHGYPVRVIIPGYVGGRNVKWLKKIWISEKENDSYYHIWDNRVLPSFVTEKDGPFAEALFHHPDTACNEQNLNSVIVKPAQGEKIPLHRAKKGEGYRIEGYAYDGGGHEVQRVEVSLDGGATWLYCIRKFPDYPIRHGNKFWSWLHWHVDVDISHVIRAKSIMVRCFNVFKNTQPREPNWNVMGMMNNCWYTVRPEITEDDDSETPSILFRHPVEPATKDGGWMKPSVENKIAEAKQEAGAPEKEFTREEIEKHNTQDDCWLVVDGKVYDATSVLEWHPGGAAAILGHAGKVHQETSDEFASIHDDYAYKKLKECALGVVTEKAANFIKQNAETAAKDATTASNKDEHLALQKHRWIPVKLIERKNLSQDTRAYTFQLPEGKNILGLGTCQHVQIGFHMLDRMLIRSYTPTKPLLPAPGDNMTNGSAKSLRDGDGSFELTVKTYFPDENQPGGALSNILDCVPIGEEVELRGPTGEIAYNGHGNFAIEGKDRHFDRVSLVLGGSGITPGYSLLARVLLSNNDKTEIRVVDANKTEADILLKEELEEFEKKSNGQLKVTHVLSHADDSWKGKTGHVNEDIIKESLFEPSEKSAVFLCGPPAMIQKAALPALNDWGYVEDENMFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4W3</accession>
    <name>S0E4W3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallothionein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4W3"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05843"/>
    <dbReference type="HOGENOM" id="CLU_220980_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017854">
        <property type="entry name" value="Metalthion_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57868">
        <property type="entry name" value="Metallothionein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0480">Metal-thiolate cluster</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Cys residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="26" mass="2323" checksum="0E2FB6CEE422FC75" modified="2013-09-18" version="1">MAGDCGCSGASSCNCGSSCSCSGCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4X3</accession>
    <name>S0E4X3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to ethionine resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_05632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431805.1">
        <property type="nucleotide sequence ID" value="XM_023578865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4X3"/>
    <dbReference type="STRING" id="1279085.S0E4X3"/>
    <dbReference type="GeneID" id="35399111"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05632"/>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MATE_euk"/>
    </dbReference>
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        <property type="entry name" value="MATE_fam"/>
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        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT69725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="504" mass="54733" checksum="53659267F4D78877" modified="2013-09-18" version="1">MPSSERRRLEGHQDSRSHIHDGVLHNETSPLLPRISEVSENGTAKSLTDVNSLLAEAKLLCQYSLPLIATYLLQYSFTVITTIVAGRLGAEELAASSLGLTTINIIGFTIFEGMATALDTLCAQAYGSGRYTGVGMHIQRMIVFMSIVMVPVGAIWLCSHWILPLLVPQRSLALKAASFLRVSLVGLPGYAFFEAGKRFLQAQGEFAPGMVILIICAPVNAFLSWYFAVKLDMGLDGAAFGQALANNLRPALLLLYVVFIGKKSHRCWGGWDSRSAFAFREWGPMVRLSVASTAVNLAEWLAFEILMVSTSYLGTRHLAAQTVLNTLSIVTWHIPFSISVAVTTRFGHLVGAGALKEARRAAILYTGVFTVVGILDGAFLYVLRNPLADMFSDDSTVRELATGSMVAVACFQVIDSIICGTNGVLRGLAKQSVAAWVVLAVNYLAAVPFAIWLELGSPDLKLDGLWIGLGSGMVIIAIIECVYMKWISWQDCVNDVKEREDDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5D3</accession>
    <name>S0E5D3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432163.1">
        <property type="nucleotide sequence ID" value="XM_023579301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5D3"/>
    <dbReference type="STRING" id="1279085.S0E5D3"/>
    <dbReference type="GeneID" id="35399501"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06023"/>
    <dbReference type="HOGENOM" id="CLU_054608_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="51"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="217" mass="23392" checksum="F42DEC454D5AE2A1" modified="2013-09-18" version="1">MSKPKNWPDGFPYLKAPLHDKSLTPTHVQALRNKPSAPSGIPIIPSPATTTPCSLVRIQPISEPSHPANGQSGLFAAQNLAPGSFILAYLGRVHSGSASSTESDYDLWLDRELDAAVDAANEGNEGRFVNDFRGVGERANAEFRTVWCERWGEFCVGVWVLGGGKKNKKKRAGIKKGEEILVSYGKGFWGERKAEEEDDAYCDGGDNGEGVGSEAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5N4</accession>
    <name>S0E5N4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable alpha/beta fold family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431092.1">
        <property type="nucleotide sequence ID" value="XM_023578256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5N4"/>
    <dbReference type="STRING" id="1279085.S0E5N4"/>
    <dbReference type="GeneID" id="35401423"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07946"/>
    <dbReference type="HOGENOM" id="CLU_020336_47_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331:SF2">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="63"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="290" mass="32032" checksum="AC9A883792643476" modified="2013-09-18" version="1">MLFKQLLAFGALANGLATRQEKPIWLTLPPTPDLPAPITHKTTHINNVSLWMQEYNKKADAIPIVMDHGGLGYSAYFGSVISRLIKHGYYVIAVDRRGHGRSTFNKNDVFTYEGFAQDTNDLLKSHGISEYNVVGWSDGAITTLAALIDPVMSEPIKKAFIFGGSANPEQTNATFSSTDIFSEFVSRCRTEYAELQPHANFTLFGTKVATMEATLPQFTDEQLGSIDGPRVIIVGAEHEEAVNRDVPEKLHKAINGSHVEILTGVSHFAPLQDPDQFTKAIEEWFEAPIP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0E608</accession>
    <name>BIK3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">O-methyltransferase bik3</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Bikaverin biosynthesis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bik3</name>
        <name type="ORF">FFUJ_06744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="72" first="931" last="946">
            <title>Biosynthesis of the red pigment bikaverin in Fusarium fujikuroi: genes, their function and regulation.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Willmann A."/>
                <person name="Straeten M."/>
                <person name="Kleigrewe K."/>
                <person name="Beyer M."/>
                <person name="Humpf H.U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="19400779"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2009.06695.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="Fungal Genet. Biol." volume="84" first="26" last="36">
            <title>Genetic engineering, high resolution mass spectrometry and nuclear magnetic resonance spectroscopy elucidate the bikaverin biosynthetic pathway in Fusarium fujikuroi.</title>
            <authorList>
                <person name="Arndt B."/>
                <person name="Studt L."/>
                <person name="Wiemann P."/>
                <person name="Osmanov H."/>
                <person name="Kleigrewe K."/>
                <person name="Koehler J."/>
                <person name="Krug I."/>
                <person name="Tudzynski B."/>
                <person name="Humpf H.U."/>
            </authorList>
            <dbReference type="PubMed" id="26382642"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2015.09.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">O-methyltransferase; part of the gene cluster that mediates the biosynthesis of bikaverin, a red pigment also considered as a mycotoxin (PubMed:19400779). The first stage is catalyzed by the polyketide synthase bik1, which catalyzes the formation of the intermediate SMA76a also knowm as pre-bikaverin (PubMed:19400779). FAD-dependent monooxygenase bik2 might then be responsible for the oxidation of pre-bikaverin to oxo-pre-bikaverin which is in turn methylated by the O-methyltransferase bik3 to me-oxo-pre-bikaverin (PubMed:26382642). A further cycle of oxydation and methylation by bik2 and bik3 leads to the final product of bikaverin, via a nor-bikaverin intermediate (PubMed:19400779, PubMed:26382642).</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="3">Expression is repressed by glutamine and at alkaline ambient pH and highly induced under nitrogen starvation and acidic pH conditions (PubMed:19400779).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 4">Impairs the production of bikaverin (PubMed:19400779). Leads to the accumulation of the intermediate oxo-pre-bikaverin (PubMed:26382642).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT67993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E608"/>
    <dbReference type="SMR" id="S0E608"/>
    <dbReference type="STRING" id="1279085.S0E608"/>
    <dbReference type="EnsemblFungi" id="CCT67993">
        <property type="protein sequence ID" value="CCT67993"/>
        <property type="gene ID" value="FFUJ_06744"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06744"/>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF19">
        <property type="entry name" value="DUAL O-METHYLTRANSFERASE_FAD-DEPENDENT MONOOXYGENASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000436340" description="O-methyltransferase bik3">
        <location>
            <begin position="1"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="19400779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="26382642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="19400779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="453" mass="50033" checksum="8F5B239B69B9A578" modified="2013-09-18" version="1">MVSNGISNGTNGTNGTTTNGTNGVNGHAALSPLEVLVQDLNKNTTTLNGYLRANKLPEPSFERDAPIINLSPDAPEEAQVAKEKVLDSALQIFQLVSGPGEYLQNVITGYHYMEILRWMSHFKIFELVPLEGKISYTELASKAGVAELRLKTLARMGMTNHLFAEPEPGFIAHSATSAALVTNNRFSDQRVWMTSIIAPVIASMVTAHERWPDSTAPNKAAFNAAFNTDLRMYEYISKQPDVYKLFGRVMDAIATSPKSDLKHLVSGFDWAGLGKANVVDIGGNIGHSCVKLAEAFPDLNFIIQDIPHVVEEGAKVIKENNEASIANRIQFQEYDFFQKQPVVGADIYLLRQIFHNWDFENSVKILKNTVESMGQNSHVLIMDFVVPEPGTVSSVNERVLRSRDVGMMQLFNSLERDLEGWKAILEAVDSRLKINAVNTPYGSFMSVIDVVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E678</accession>
    <name>S0E678_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA (Uridine(2843)-N(3))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430118.1">
        <property type="nucleotide sequence ID" value="XM_023576973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E678"/>
    <dbReference type="STRING" id="1279085.S0E678"/>
    <dbReference type="GeneID" id="35400270"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06793"/>
    <dbReference type="HOGENOM" id="CLU_028833_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44762" checksum="77BF3F8CD98AF7BF" modified="2013-09-18" version="1">MKKFKRSAQSQPKHGKPQSSGASKAPVAPPVRRPGWTGPSYLHKPAKKTPTPVKDTTSSTEQIQSLSVKHQQLILDTIRTTFPAVDEFSALKPVLREIREALEQKDYSKAFGSQEFLEAYTIRWSPSRALTMGNVLAWICSEMSETAWAQQFLHNEQKPSKIVCFGRGGSDLLACVALLKHSHENKLDEIPRSESSSTDNDDSAMVDVNLIDRHDWSGIVTKLQHTLTHPPPLSKYATAKARASNISAIPSQVLDLSVNCLNILESDSTTLRTTIGPNPALITLFFTLHEFYSISISKTTAFLMRVTEIAPKGSLLLIVDSPGADVVLPGSSEKGEEKKYPLEWLLYQALLPPKSISSEEEKQPAWTKLIESGHEKEYKLPAGLRFPGSLENTRFQVHLLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6D4</accession>
    <name>S0E6D4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_07866</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431377.1">
        <property type="nucleotide sequence ID" value="XM_023578167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6D4"/>
    <dbReference type="STRING" id="1279085.S0E6D4"/>
    <dbReference type="GeneID" id="35401343"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07866"/>
    <dbReference type="HOGENOM" id="CLU_051314_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000017">
        <property type="entry name" value="Phosphatidyl synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT69297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="284" mass="31242" checksum="F15F62191824DCD1" modified="2013-09-18" version="1">MSLSARLAWRATTRCTARSIPALVRSAPRSTIASTPRCLFFTKAQSWSDHKPQQKKPEENPPGTQPVHDNNTKPSRPAAVLHEDIYTLPNILTFTRLVAAPVIGYLVLHDQHAWAVGLFAYAGVTDLLDGWIARRWDSKTVVGTVIDPMADKTLMTILTICLAAKGALPIWCAGIILGRDVGLAISAIYYRWISLPPPKTFARYWDFSLPSAEVRPTTISKYNTFLQLALVGVTTAAPLLSTDLSSALTVMQYVVAATTIWSGASYIYTKDAVKILNKQNSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6F8</accession>
    <name>S0E6F8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IPL1-Ser/thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432480.1">
        <property type="nucleotide sequence ID" value="XM_023579688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6F8"/>
    <dbReference type="STRING" id="1279085.S0E6F8"/>
    <dbReference type="GeneID" id="35399847"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06370"/>
    <dbReference type="HOGENOM" id="CLU_034015_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="199"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="517" mass="58957" checksum="B68FC7B488B69185" modified="2013-09-18" version="1">MDIDQTVFYLSSRNRYASEIIKHPDNSNRTCQDPKDPKKLCLRIGLDQESKSPPFLVSFGRRDQNDVILGKGFPNAQCYFDFNNESGELLLHDISEACDTQLQEIESINNDYEDEDGDGETKEKLGFPQISKTRRRCVVLLGPDLYHDRIEWHFQIRNARFRLIPGPTQLIKELQVKGSLALEPHSTSPKQGSDKVIRFRKLKPLGSGSQGEVHEVVDLDTGTHYACKLVDVMKGATEWKNHTGKFYRARVIWEVEMVRNLMHPHIVPYTHVRELVASPNIQIFMPVYEGNLYNLLEEPRVDGKEGVRDIISQMLYQMLQALDFVHSRNPQIIHRDIKPPNILYRGNNFFLTDFGIAKAVDTSNTVVGTPNYMAPEVREKREQTSKVDIWGLGVTVVACLENPKDFEEEGSRTDGEKWYEYLQKSLSQHHSSSLTSMVSVDPDGRPAADELLRQHWPTGATLSSAAAPLSPQPRGTITPILMDWVRTVPETQPARPVKRKRSSYDAQLPPPKRFRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E789</accession>
    <name>S0E789_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432848.1">
        <property type="nucleotide sequence ID" value="XM_023579552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E789"/>
    <dbReference type="GeneID" id="35399725"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06248"/>
    <dbReference type="HOGENOM" id="CLU_1461425_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="185" mass="18573" checksum="16DC03D777CD4825" modified="2013-09-18" version="1">MMFAVLHVSAGPCKPSSSTVDTTTTVQTPTTETSSATVSESFTESLTSLGSNQTTDINSLSTSAETSTALGTSTTLLFMTTEEPTSSVAVSATTSAAAAAVECSTNADCDGAAPFCDAGTCVATDPNAECSTNADCNALHGGDAPFCPAAGNCVGCRGDGDCYGETPYCDNDFCTDYVGLGGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8G4</accession>
    <name>S0E8G4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable PCL7-cyclin like protein interacting with Pho85p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433263.1">
        <property type="nucleotide sequence ID" value="XM_023580496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8G4"/>
    <dbReference type="STRING" id="1279085.S0E8G4"/>
    <dbReference type="GeneID" id="35402242"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08766"/>
    <dbReference type="HOGENOM" id="CLU_013692_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="499" mass="53437" checksum="66ABF8C60B187D43" modified="2013-09-18" version="1">MAAVIGDIISDTSYPHTMIANPSLQHHHSHDSSSSYRSGSRSRRSTTPRAQRTAELADFSSNHSSATWSHAPASASASEPTSTPAPAGHETAHVSATGGASRFPSPPPSSSPAAATGPAYADDAKSPSMASDARDSGPLGHASQPGPTSHNSSAQQPSPASDDFQIPNPSFPVSGASSQTPAQTVIHIRDLAHIQSLASADLLSGNGGSGILNDPPLQQMKYEISGMPIGDIIEMVAALLTKITTTNDLQHDAMQRNVAHQQQANQSGDTSGSSISSLNHSVLAFHGKNVPAITILSYLSRIHKYCPTTYEVFLSLLVYFDRMTERVNDMVTRNEENRRQTRSQQSNATSPQDTPMRGEGMDVDESDSDLADDDDEEMADSTRPSRTSSHRGAATPTEYSGITAATYFVVDSFNIHRLIISGVTCASKFFSDVFYTNSRYAKVGGLPLVELNHLELQFLLLNDFRLAVPVEDLEAYATMLVEFYAREVVAKQGVTGNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E959</accession>
    <name>S0E959_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to SGF73-SAGA associated factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433488.1">
        <property type="nucleotide sequence ID" value="XM_023580768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E959"/>
    <dbReference type="STRING" id="1279085.S0E959"/>
    <dbReference type="GeneID" id="35401997"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08521"/>
    <dbReference type="HOGENOM" id="CLU_044734_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="215"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="410" mass="44383" checksum="8D5D9E3563BCE15C" modified="2013-09-18" version="1">MGTDARKGDDGTIKVASKNKNGKIKLKKPAPKHSKPGNWMDGSVIESNNKKKNGALPVGAPSPGPVVNELDETSRETFATGRPLEDSPDLQQCKHCKKSVLKTAAKAHIAQCLRLKKEKAQRKKEAREARERAKEAARQEEQRKEDEENGVERGDDDSDDDGISAEKKATGSKTAKKAAGKKPEDDKKGKKRKADGDPDKGPKNKKKKDEPKAKVPKPKGPVDVERQCGVLLPNGQPCARSLTCKSHSMGAKRAVAGRSLPYDMLLAAYQKKNQAKQQKAALDANAPIEDEDEANNGPVDSDEETAAVMGALSQWRPQPLIPQPTFTPIKRQYQLARLHEQLQMATNGGRTNIFSVTGFGAQKLPEGHPGLQPASEDAPGEIDITTGFNNAGRTTATFTSQRQPSVSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0E980</accession>
    <name>S0E980_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable 26S proteasome regulatory subunit RPN8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_08472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433530.1">
        <property type="nucleotide sequence ID" value="XM_023580823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E980"/>
    <dbReference type="STRING" id="1279085.S0E980"/>
    <dbReference type="GeneID" id="35401948"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08472"/>
    <dbReference type="HOGENOM" id="CLU_027018_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT71451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="344" mass="38314" checksum="57A47990D4CB3BA3" modified="2013-09-18" version="1">MPTTTAETLSLVTRNVTVAPLVLLSAVDHYNRTVSTKTKRRVVGVLLGQNDGNDVRVSNSFAVPFEEDEKDPSVWFLDHNYVESMNDMFKKVNAREKLIGWYHTGPKLRASDLEINELFKRYTPNPLLVIVDVQPKESGVPTDAYFAVDEIKDDGTTTARTFVHTPSVIEAEEAEEIGVEHLLRDIRDVAAGTLSTRVTNQLQSLQGLHLRLRDIGTYLQKVLDKQLPVNHAILGNLQDVFNLLPNLSTPEGDGKSGGGELAYAMSVKTNDQLMAIYLSSLIRAITAFHDLIENKIQNRQQQEEKEAKKEEINGKDEKKEGANGSSGDSKEGAEKDKENKETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E985</accession>
    <name>S0E985_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_08727</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433299.1">
        <property type="nucleotide sequence ID" value="XM_023580538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E985"/>
    <dbReference type="STRING" id="1279085.S0E985"/>
    <dbReference type="GeneID" id="35402203"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08727"/>
    <dbReference type="HOGENOM" id="CLU_026434_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT71220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="521" mass="59784" checksum="CC60CE4E3CDFF7A3" modified="2013-09-18" version="1">MAEKSGVTGADFEFVKTPPYPKPDFDKLEDVGVPTTRYPAIKNAPLPADGSGADTFNNYVLISILVLVPWFLSRKVGGGFKTTIFFALIVDLPLLAAWWLVISSISPRKNEKVRLPNRGVEHYLEFKKEADRLKYRGSNKIPMETFHEMYFDGDVDFKGDCLEVMEYRHDWASFRFTIGLIKFFLFGMIPEVIMHTRSQDEEQVRDHYDRGDDFYGWFLGPRMIYTSGIISDINREETLEELQDNKLTVVCEKIGLNKGDSMLDIGCGWGTLARFASEQYGAHVTGVTLGRNQTAWGNSSMRKAGIPEEQSKILCMDYRDIPVPEGGYKKITSLEMSEHVGIRHFGSFLKQVHDMLDDDGVFFLQYAGLRKAWQYEDFTWGLFMNKYIFPGADASTPLGWVVDKLEGTGFEIKHIDTIGVHYSATLWRWYRNWMSNRDKVEAKYGKRWFRIWEYFLAYSTIISRQGSATCFQITLVKNINSTHRVEGIETQFAITGALDNCRADLQSWASRNNVKTPSEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9B7</accession>
    <name>S0E9B7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to lustrin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433553.1">
        <property type="nucleotide sequence ID" value="XM_023580851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9B7"/>
    <dbReference type="STRING" id="1279085.S0E9B7"/>
    <dbReference type="GeneID" id="35401924"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08448"/>
    <dbReference type="HOGENOM" id="CLU_054979_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="357" mass="36846" checksum="674A3B31B133223B" modified="2013-09-18" version="1">MKSVVASIGMLAAVANAYNFPHHAHYRRDNGTDTQTTLTVKTTVVETITSCAPTVTNCPARDHTAIAQLPESDKVTYVETNTVILTEVVCPVADASSIYTSVLHDAETGGVTGKTLTAPYTASVPMTTGGAYPPPKEGDKTVVSDYTTEQVVTLTQGDETITTTIHKTLQTTITVPAGPQVTDDGSKGNGTPEDDTTTTTTKTKTGTVTKTIERVGETNPASGGDNGYSTGKSEEEGSKGTSNGSGNGSNNGGSGSGNGNGECVAETVTVTAPASTVYVTVVPEASKTGSSDDATVTDKAVHGDDSEDDDSEDDDDEDEFCDTTTTLEATVTVVPYPVNNTATGGYAKPTGFSRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9X1</accession>
    <name>S0E9X1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT-NTPase sigma domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_08232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433753.1">
        <property type="nucleotide sequence ID" value="XM_023581090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9X1"/>
    <dbReference type="GeneID" id="35401708"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08232"/>
    <dbReference type="HOGENOM" id="CLU_000288_182_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031353">
        <property type="entry name" value="NACHT_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17106">
        <property type="entry name" value="NACHT_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT-NTPase sigma" evidence="7">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT71674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="354" mass="38334" checksum="BF128D9C581F476F" modified="2013-09-18" version="1">MDRPSLTNNAVAALATTGNDFPDGIKIWHSPEDAGLDICFIHGLSGNRDKTWTAPGQPNPWPAELLPTRLAKARLLTYGYDAYVLKRSVSSTNRLIDYANNLLHDLAAERASSGTVNRPLIFVVHSFGGIVCKTALIISHQSPESHLGQISNCTRGIAFLGTPHRGSWAADWAKIPAWALGQVKSTNRSILDVLQINNQYLEFIQTSFLSMLRDLDKKGRPLQISCFFEELPMPGIGTIVSKESASLEGYSVFSIHANHSDMAKFGSAEESGFKRLLGELVRWDAMLGTGDSTISPVAELESNGKTPNATSSLQTTTGHIFNVSGGAQHNNTGAGNQFFGNFDGPVYFGLPSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAG5</accession>
    <name>S0EAG5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_08532</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433984.1">
        <property type="nucleotide sequence ID" value="XM_023580756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAG5"/>
    <dbReference type="STRING" id="1279085.S0EAG5"/>
    <dbReference type="GeneID" id="35402008"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08532"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="97"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="393"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT71906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="459" mass="51687" checksum="4C7DFF9AEE7BEBC7" modified="2013-09-18" version="1">MSSKSQWADTEEDARIDAKLKEEKRRKKAEKARKIEEEKKAQEAVQRKALQLDDDRPSKRRRITPEPGANQQGKAPPAKLLRFPSGAWGKCRSVENYEKLNDIEEGTYGWVARATNKATGKVVALKRLKLEPQDRNGLPVTGLREIQILKDCQHRNIVIMEEVVVGDDVSRPDNQASSLFLVLEFVEHDLKSILDDMPEPFLSSEVKRLLLQLTSGIAYLHDNWIIHRDLKTSNLLLSNRGQLKIADFGMARYVGDPPPKLTQLVVTLWYRAPELLLGAKTYGAAVDMWSVGCIFGELITREPLLQGKNEVDQVSRIFELCGVPTEEIWPGFRRLPNARSLRLPKTQGATGSVIRARFPGLTTAGANLLGDLLSLDPERRPSASEMLQHEYFRQDPKPKPESMFPTFPSKANQERRRRAEPHAPVRGGQAASLGDADFSGIFQGRDKEERGAGFQLRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAG6</accession>
    <name>S0EAG6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_05948</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432831.1">
        <property type="nucleotide sequence ID" value="XM_023579217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAG6"/>
    <dbReference type="SMR" id="S0EAG6"/>
    <dbReference type="STRING" id="1279085.S0EAG6"/>
    <dbReference type="GeneID" id="35399426"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05948"/>
    <dbReference type="HOGENOM" id="CLU_093932_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT70752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="110" mass="12735" checksum="E21331541D9F4834" modified="2013-09-18" version="1">MLLFCPHCANILTVSLTNTRTNRLECRTCPFEHHITEPVFSRRMYERVEKEDVFGGPGAWDNAQKGRVQCPNEGCEGDEAAFFQVQIRSADEPMTSFYKCMTCGHRWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAT9</accession>
    <name>S0EAT9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434077.1">
        <property type="nucleotide sequence ID" value="XM_023581369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAT9"/>
    <dbReference type="GeneID" id="35407460"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14006"/>
    <dbReference type="HOGENOM" id="CLU_061836_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="287" mass="32260" checksum="6419D2B1D987EF7F" modified="2013-09-18" version="1">MPHIKQIAAGRRKPNMTRKEFFDHRFRIHGSLSDAIEDKDQKPYKYIQTQVFDSAFGSRPGGPLNANHNWVGRDDTTELFFRDWDHVQKCFSSDYVKTTIAPDGPFFADFETSVVLMAYEKTIPLETQAARKRAAGVSGAMNSGDSTVAMYFISTPDDKKDGESLEQTVTPRLVDAINSYCQDEVWGLICNVGTVSDQFDLNSYFGGANMPQYALVYKLFLAGPESVPLVRKAQAQFEKDAQSSVDLNKPFILFSQEALVMNVTEGVRFNRNRQPVFKDLPGSSHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC00</accession>
    <name>S0EC00_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_08612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433406.1">
        <property type="nucleotide sequence ID" value="XM_023580666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC00"/>
    <dbReference type="STRING" id="1279085.S0EC00"/>
    <dbReference type="GeneID" id="35402088"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08612"/>
    <dbReference type="HOGENOM" id="CLU_035008_5_1_1"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT71327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="331" mass="36227" checksum="3BD63B949784F2E8" modified="2013-09-18" version="1">MASQHKPVVSFLGPVASYTHQAVRQAFSESTWEFSPAVTIDDVFDQVQSGHVQAGVVPFENSTNGSVSFTLDNLADRTNHYPDITVDGETYVDVHHCLVGHKSPVPAVEDIAEGSGTCTPTATDPSPSKPRSRPLASLKHIQRLYSHPQAFGQCTAFISTYLKGVEIFEVSSTSKAAEIVSKDTTGTWAAISSELAAKLHGLDFLGRSIEDREDNTTRFFVIGKNAAGPKDLDQTKKAVAEKGSKSLVSFTVPHTSPGALADVLSCFRTFDINLTSINTLPSLVKPFQYIFFIEFEGHKYVDPEGRVNGALEKISRVAESWRWLGSWERYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECZ4</accession>
    <name>S0ECZ4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to Rossmann fold nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT72749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECZ4"/>
    <dbReference type="STRING" id="1279085.S0ECZ4"/>
    <dbReference type="GeneID" id="35406097"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12641"/>
    <dbReference type="HOGENOM" id="CLU_058336_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="216" mass="22862" checksum="D6E2A0F98DAF5095" modified="2013-09-18" version="1">MSPVARTKICVYCGAGTGASPAHMEAARALARAMAANNTDLVYGGGTVGLMGEIAKTLVSINGPQSVHGIIPEALVKHERAGSRQAQNIPDEAVFGRTTLVKDMHTRKKLMAEEVFAGGPGSGFIGLSGGFGTMEEIFETTTWIQLGIHSRGIVLLNIDGYWNGIIDWLDKAAEEGFVKPGNKGLLGVAETGEGAINALREYKVSSSIYQLQWGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED10</accession>
    <name>S0ED10_GIBF5</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434578.1">
        <property type="nucleotide sequence ID" value="XM_023581976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED10"/>
    <dbReference type="STRING" id="1279085.S0ED10"/>
    <dbReference type="GeneID" id="35405833"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12377"/>
    <dbReference type="HOGENOM" id="CLU_015711_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="563" mass="61706" checksum="C46743D85D182B46" modified="2013-09-18" version="1">MEARSLTALNNLAGNPPQYPINPAQEKQDPLTLYISRVPGTRDVILSPFKPQLKNVTAEDVASCLYYVHFEAPSLEPAGPPRDDDHRSSSDESSSIRNIKRKPLPGGARPLTPPPTDHLPVPGYGNENQDPTRRRGLSVNSTFDPRQTSARHGYEQEEESPVLPPRPKNVPRIQTPEPAVARKPLGPRMTSNNASALGDHPLPPLPPPNQGGPDFDRMRATSRPPLPNRNTENRSPSPRKSYEGKQPFTLALIRRDPSTGNQWNVGHISSFQSEAPPPDQDDANPLFASVPPVAQPPTSGNPPINVQIETLGYGKFRGMPARRSFDAGPGSDMTQPRDGGIVLQRQIAMAYGKSWASNWREKLQDGTGKGHGRQGSVGSIESTEASSPVEPAISMHPGPGLRPRGYIFTSPWNGRCEFRTGAAGRSLRCYHILHDDRPSNPLAEFSQGQIQGGGSGMPMSELRFNLPTAELFKSAEGREEVKTQLQGHFNKLLRRDERSDGYDNDGMVSPFDINLGKEKAGGGNRGKRAKLGKLIIYPDGLKMLDLLVSANMGLWWQAWEKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEE8</accession>
    <name>S0EEE8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435103.1">
        <property type="nucleotide sequence ID" value="XM_023567780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEE8"/>
    <dbReference type="STRING" id="1279085.S0EEE8"/>
    <dbReference type="GeneID" id="35406381"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12925"/>
    <dbReference type="HOGENOM" id="CLU_031471_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF4">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485162" description="DOMON domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="4">
        <location>
            <begin position="51"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT73025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="398" mass="42514" checksum="441A8B006BD4696D" modified="2013-09-18" version="1">MIRSLDIVFAFVLALCEYFPPSVVTGDLRSLRSVAAVVHASPASYCDASSSKVCYSWAVPSSTSSLYIRLEAPTTYQWIALGTGSRMSGSTMLVIYQDGSGNVTLSTRKGHGHDTPTYQAMSSIKLVEGSGVSNSSMVANIYWKDASIQGTANWISAWKKGSSLDTSDASSDFAEHDGTDSFSVDLSKATVSGSSNPFLNSSNTTPSDNAVSGGGGGEDHTGSAHGVIMAVVFLVGFPIGSFLMPLLGKWLIHASWQIIAFVGMWIGFGIGKIAADRGGDWFHEPHVVLGTIVCVLMIVQPILGWMHHRNYVKYQRRTTISYGHIWYGRAIMIVGIINGGIGLQLSSASTALIVGYSIVGILVSAIYAAGAVRKMVQMKRKKHELLSDPSNSALELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEL0</accession>
    <name>S0EEL0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_09905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435484.1">
        <property type="nucleotide sequence ID" value="XM_023568140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEL0"/>
    <dbReference type="GeneID" id="35403372"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09905"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF57">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="500" mass="55848" checksum="90806FCBE0BF6A51" modified="2013-09-18" version="1">MLHQHENKVTSGQVDSSSTEKVDYEKAVSFHEDASQEVFDEPATKRLLRKMDIKLLPFLALLYLLSFLDRTNIGNAKLAGLEDALGMTGKWDYNIAVAVFFPFYVAAEIPSNMAMKRFRPSIWIPSIMIAWAIVTTLMGITKNFGGFLATRMALGLAEGGLFPGITYYITLWYKRHECGLRMAIFFSAATAAGAFGGLFARGVMEMKGLGGLDGWAWIFIIEGLITFVFAIMAFFVMHDYPDTAKFLNDSERKEVLRRLEEDRSVLSDAFNMKFAKDALKDWKIWVHMMITIGIYTPLYSISIFLPTIVKSLGYTNEMAQLMSVPPYVVACLFTIGGGFAADRHGQRGIYMIFFCVVAIIGFIILATVESHGAKYFAAFLITCGIYPNVPQGVAWNGNNIGGSLKRGVGIAMHVGFGNLGGAVSGFVYRKDDAPNYRSGHWTLVATTTMSCILSIFMTIYLRRENARRDQTHKAPHEYTRAEKELEQDSGDNATFFRYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEN7</accession>
    <name>S0EEN7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to MSP1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435514.1">
        <property type="nucleotide sequence ID" value="XM_023568291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEN7"/>
    <dbReference type="STRING" id="1279085.S0EEN7"/>
    <dbReference type="GeneID" id="35403237"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09770"/>
    <dbReference type="HOGENOM" id="CLU_004223_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="741"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="646"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1015" mass="113110" checksum="B1964F6A61B9FBAE" modified="2013-09-18" version="1">MQSTGLRALINPAIIAARSQARYRIRYRSFQTSSTWRDTGAGAGAGANNGDKPPGQPAAVEEEDVQPQNGTETAPGRSRVRTSTSVKNRIARKHAAPALPPVKLPQTFLDDNVTLHHARRRPRLPIALAEDAKQPKTSSVFVDPQVADKKTRTTESNRALEDYFDATFTAMFEKVADRVNAVVALDASCHTEELVHELTSLTRASDMLLDSAWHLADSLYPARHAEYIYTSKPFWWWHYYKDFDRHAQEFRDQFLSVQTGLDSILDYDWRLDHSLAQAIADLPILTFSSIRSALRRELTTPPPPDSESKNLKRQITLLSMSGYSGQAISEAVAEHIAYFNDADLVKLNAQDLSVIVGDYLDQDWAYSRGSLSNMGFRAAEMNGKLYKDPDVVTRHEEEDNDPDTGVINIRAASGSLEDELSKIKQGGYDPFGKWENLKIDKVLDQIIQAAEIKQGSPREKPLIIHIHDFIELSMTLEGSMLITRLRNIVDSAWQQGSKVAILGTSSSEQPSEEYQSTLRDLSIGDFVISRHIDPSRTLRQPKPSGGLQTSNGHFALQDTDIFVENVQNINRMLKSLGSQCTLELSDAHMKIFMHATDTRAQMLKKSILPLPEVYNIACAAKRHEEEAAGAAPGGVYERLLMGPLRQRPGQRYLDEPEQDSKTEGKDSQKKDEDSQPGGRTAMKLNEYEKRISSGHINRQNLRTTFDDVHVPKETISALKLLTTLALVRPDAFSYGVLAQDKIPGCLLYGPPGTGKTLLAKAVAKESGANMLEISGATINDKWVGESEKLIRAVFTLAKKISPCVVFIDEADSLLANRSMLGARASHRSHINQFLKEWDGLEETEAFIMVATNRPFDLDDAVLRRLPRRLLIDLPLHADRTAILRILLKGESLDPAVSLESLARRTPYYSGSDLKNACVAAAMAAVEEENEAAARYSGPEPYEYPQKRILRQDHFDKALRQIPASISEDMQSLKQIRKFDEEYGAKKKGAKKTMGFGVGVEKKLADAEDVRIRRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFH9</accession>
    <name>S0EFH9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434675.1">
        <property type="nucleotide sequence ID" value="XM_023582089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFH9"/>
    <dbReference type="GeneID" id="35405934"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12478"/>
    <dbReference type="HOGENOM" id="CLU_097601_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="241" mass="27941" checksum="C11321F05BE3583F" modified="2013-09-18" version="1">MSKLTKNSCKVQMRPLGLGYGSIKTAAEIVSLSFASDPLIRWLSRDRSGPGWETLTPTLQQWQEARLREYSVRGIAMEAVTMDDSHKSIGSCFLFPPKPLYRWLNPLWWPSYSRVLWDEWWIKPTEPFSLEKRIGIMMNSHNDFEQRIKEKYPPNSLYYLEIAAVRPDAQGMGVGRTIMQWVVQELGDDPCYIECTDEKNVAFYAKYGFEVVEEAELVDEEDAMPPTTLFYMIRDTSTLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EG31</accession>
    <name>S0EG31_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to heterokaryon incompatibility protein (Het-6OR allele)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435812.1">
        <property type="nucleotide sequence ID" value="XM_023568649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EG31"/>
    <dbReference type="STRING" id="1279085.S0EG31"/>
    <dbReference type="GeneID" id="35402916"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09448"/>
    <dbReference type="HOGENOM" id="CLU_004184_12_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="47"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="685" mass="78382" checksum="F4E8BE1D36D9E8C9" modified="2013-09-18" version="1">MSTSKDPRLYAPLDRSRRHIRLVEILSAKPKIVYNLTTISLDEATKFSAISYLWGDKGKTEPITVNGVEQFITPSLANALEYAPYHWANAFPERDPRSCRLWADALCINQDDDLEKGHQVQLMKLIYPAAEVVFSCLNIEATQSDIRLAFKACETLAKSAAEHGLVSSLIDIDATIEEKHIQELGWLLRHPLLDENYPVKSQEFADADQAMYRMLKLKYWERAWVFQELVLSRRVVVIHQLLSIDLKLLLDAQSCIDIIKEMASGPETDEADQYFWYIYWQRFLTLRQVEWARVCVYEAAKADESIIRSMRSFLLVGGMYRAKDPKDHVYALLGLTTLYIEPDYTSKTTVASVYSEVCAEILKSQKSAKGWPLCFLSGAGLAKQGKNQQYELPSWVYNFPETFKGNTVAHFLFRGYEEPNYHCPEEWNSLEPTSIRGDSLTCSAVFFHTIIDASPALEESCDSWLSFVSAIFRMIHRPMGNTEDPHPLWALARAFGADDGQVNIWETPAATRMVRMLQYLSLICQVPIHDDGRYEADAAQKAEEFAQGILDKLPENIMYQDSEQPPENRKRNESTSKIYRELISQIRDKESFWDDMDNQQVQPDISACLKLEPAIGLTDSGEFVLLPRVAEIGDQVVLLPGYWQLSLVRKEDNHFVHVGDCWPCRTMQQVAEPARAKEMKVIEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EG60</accession>
    <name>S0EG60_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434900.1">
        <property type="nucleotide sequence ID" value="XM_023582354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EG60"/>
    <dbReference type="STRING" id="1279085.S0EG60"/>
    <dbReference type="GeneID" id="35406171"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12715"/>
    <dbReference type="HOGENOM" id="CLU_007091_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF129">
        <property type="entry name" value="ASPYRIDONES CLUSTER REGULATOR APDR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="123"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT72822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="576" mass="64856" checksum="3E01703B6AF11362" modified="2013-09-18" version="1">MASSITNSLQNLPLAQTKSSGRSSAAQTREREYSGTEDHERHWYEPFSICEKLKFLVDNLSGDDFHLSSEQETLGPPFETYKKLLRDIRRNQEVRITSENLVSIQSGARGMLPARRTCDSLVDAYIKTFESVLRIIHVPSFLRDYEHFWEDSTSTVSSSDETFACKLLLVAALGSITFTPPESQQGQATSCREQSNNWISYVKDWLARKSMKGMRGDLSLAEIACLLALTRHTHHQDSAPMGVAWLSEGHGLTHMAVQMGLHREPRVRSPNMSPKEAEIRRRLWATMLELSLQVSVDQGLPAPIAPESYDCEMPSSMADEDLVLGVESQGPNQSSVLTLLAKTQRLRLRILQLVNAPGSSNTYQECHNLASELNTECSASDLKLGSPLSDFQTGFLTSFTKPFVLALHEAFAEEAYSKPEYYYSRRMRMEISAQLLSSTTSQGPYPALLTNGSGQFSIMYRQATMSLCLDLIRDFEEDSFPNLDSASRAQLRGILSNAITTFKRRVETSRGSESTEEFILFSCAFSYVESLHRREDKDKMSVKMNETAKTVLKVCSDVMERQRRRESLAESDIWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EG75</accession>
    <name>S0EG75_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436079.1">
        <property type="nucleotide sequence ID" value="XM_023568150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EG75"/>
    <dbReference type="STRING" id="1279085.S0EG75"/>
    <dbReference type="GeneID" id="35403363"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09896"/>
    <dbReference type="HOGENOM" id="CLU_011743_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="668" mass="74844" checksum="7AB6C664585241F0" modified="2013-09-18" version="1">MATTDRPRRRFVPEPIETTFSTSRSSNRSDEKKTPRTMRPNPEPTPEPSPRSPSPGLNELQKKHQQRPKRRFAPQLIESSRRSRRVGDAGPATKPTDKTDITPYTKNIYTATKHRGRRRDDAHESPSNGPRRRESEDENVVSFLLEIAAKEAERQMQEAALAAFPNSHVREGNVDHFYFRESSGSDQSPESTSPMHDHHGHPVKHHHNVRRQSSDSNLGWWHKHMQEHVEAKQEQEQQQKDDDAMAIDEKPGEMDTLVEEPAVEAPAVKKDEDVMMRTDTADLDAMDLEPPPDPMWTTSNTPRDSSSKRSSIGVSGPIGETHMPLLDTESYLTAEQRSKASSPAPAASRHIGESTMPFIPSAPAVGSADVPYAKASQIPPDTGGFAATRNLARPFGYRPFGRGSPAPSFQKKRLGVTPPMLGKDLVFRRCPSPKQTKLEPDHPFAERHAEEKFRDLSGQNGLWRGYCFRSDSNDNYLVPADLHAPPMLATPRPAATPGDASKISSPPYTDEPVMIGAANGQANGIAQHRARAGPPKGLHMLHGINERLQKEKAHAELEDKIEQEFDDSFVTQVYNYLSLGYPAMARAFDGELSRISLMSIEDLERDDEKQLAQGHLVESEADKPRDQRCPRWHALQSYIKEWARQHPNLDSMDPVGWGVRERRGSWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGD3</accession>
    <name>S0EGD3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to levanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435937.1">
        <property type="nucleotide sequence ID" value="XM_023568797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGD3"/>
    <dbReference type="STRING" id="1279085.S0EGD3"/>
    <dbReference type="GeneID" id="35402784"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09315"/>
    <dbReference type="HOGENOM" id="CLU_001528_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF1">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="41"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="381"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="535" mass="58918" checksum="D2495BD25BA66AE1" modified="2013-09-18" version="1">MLRFLALVPRTLAFRLFPVLLFILYVSAVPLATTNTRPSYHITPEKKWMNDPQRPFFLGDEWHLYYLYNSNFDSSNPGSGGTEWYHITSTDMIHWTRRGVAIEKYKPNPPSGIVLGDIETGSAVVDTNNTAGFGRNAVVAIVTQMADGLQQQSLFYSTDNGHNFVPYEGNPVMPNPSPTTKPAFRDPKIFWDAKEGHWVMSLAEGDKIGFYTSADLKTWAYISEFRPENAGVDLETLECPDLYQIDLDGDSTKRTWILALGANGYRYNRTTGTAYWIGNWDGNRFTATESFPQWMDDGPDFYAAVSWENPTDRYGSRYAIAWMNNWDYAASLPYYADFAGQDSLVREVELKTINGSPTLVSIPIGGYEEILASPMSVSDKTITTDPASASLPSGMEQGAYMIRATISKNGGDKGNEVRFVIKSDGAFSTTVGYDFVHSQAFLVRDSDGSATDSMAAGSKQVYDTVRTAPDPSGGSTVKLTIYVDWNSVEIFVNDGVAVLSGLIYPNQGASGVQVVSDTGSLTLVSFSYAACGSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGR6</accession>
    <name>S0EGR6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell surface glycoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436057.1">
        <property type="nucleotide sequence ID" value="XM_023568942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGR6"/>
    <dbReference type="STRING" id="1279085.S0EGR6"/>
    <dbReference type="GeneID" id="35402654"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09185"/>
    <dbReference type="HOGENOM" id="CLU_488363_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485913" description="Cell surface glycoprotein 1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="55472" checksum="557A9E26F09A64BF" modified="2013-09-18" version="1">MRLLKGIVLGLLLERGLCQTDTQPDGDSIATVADPVETDPADVPAPDPTVPSDGDTPSDPPDPADDGPTITLDDPQPTDDGSDARIPAPDPTDQPTDVEDPSAIPDDPAETNTDDEQQAPTDQPAPTDTEPAPAPTDVDATQTDEETPQETDTNGEEATQTDGDTDAAPVVPTEALNSAAEETPEATPLASDTADDQVPQTTEEPSDGETEEPTADSEPEESTQQKTRNLVAPTNTEKSDAKTTDGDGNYSPAPYASPTGGDEAEQTGDSEQTADGTTRKAAATGSGGKEEKTTLATSKGAAPTSPAQDYAIDLKEADLGDYAEFQGAGDKTVVVLKPPPNTEAKCDLPPTSDEDVPEGEDVRVVLAVKIADLKKGVKSGNRLQMLVDGSTIYDKELLGTGDEEESISSDKFRAALDQKVNVIHKAGDKPVQVTIQDANIRSAVSAGSRGGSGGGSGSGSGSGDDGDDSGDGDSGSGGGGSGSGSGGGSGSGSGDSDSSGGGGASESASGTGDEGASPSSVSGGDGQTNVAGKNFMVGEVLMYALPLAVALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH53</accession>
    <name>S0EH53_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to aminotriazole resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_10404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Nectriaceae</taxon>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
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            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="GeneID" id="35403869"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10404"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
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            <begin position="51"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
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    </evidence>
    <sequence length="109" mass="11912" checksum="17DE0287F77F8ADD" modified="2013-09-18" version="1">MPTQEVLNQWEASSPTTRSEGPLQGTSNPPQSLVSKHECFAARPTAEVCPTCNDGRLALDQDRVRNNGARTPGSIHADIVAQIEAKRERKASEEAEKDKKKAEVEEKSA</sequence>
</entry>
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    <accession>S0EIU4</accession>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
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                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
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                <person name="Proctor R.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
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        <property type="component" value="Chromosome X"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
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        <property type="entry name" value="DUF7025"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="667"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
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        </location>
    </feature>
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        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="932" mass="108374" checksum="6014A8D765227261" modified="2013-09-18" version="1">MARTAQTRAKRGGRRNTTNNTRNTRNHKENDLEYMALKQEAERRERILADRRRTAAKWRPKIPEVRKVNFENFKNRFQDIDEPDYAIDVLMSGTGTQAQIRREHGLRRREEMARLRQKYMYYPGGGVIETPHRKTDAYERARRERDSQPSSDSEIQRIRIQSQPILGHLTALMNDTEKRSSPRTFMRPFKTLVHFQPKMREILATLEDKWADFEDIGSESSEVVDVAEETEAEVVDEEEAAEDGDDAASQTSEASSIESVDSDADEDYDNLMDSPEALRDMRCYVDFVDKEVLPLYNRFEGSTADRVKFDDLWSLFRVGDLIYMPASGETGGRYHEIWRVYKVRSPEPETSYPTSGWDFFADEQQIDENSKFKISAYYIDHDGNTFGAVRRKFEIESFIGERSIDSLEAFPIRYRHDYKQLLSSMQDQGRKFINYLDDRHQQYSAWTLTRNPPSHRTEPEEEILDNEDYEKMRHPEFVESDVIVDLTEAYQKMPDWRPRFHQLTINKSSRCEIKDDEMPIQHWFNGTRQNLAYSQNEIIQHADGVEARQRRDNLAVDAFLRVRVKGSRTFETNTKALELRDEDLVLLPKRMFAYALRERRFLPIDLNVLKPVRREPGVFENLRIQSDYKDVVRGLVMSHFQRKVLERKYADAATEGPSQDLIQGKGRGLVVLLHGVPGVGKTATAEAVAMENRKPLFVITCGDLGLTPHEVESSLKNVFRLAHLWDCVLLLDEADVFLSQRSKQDMKRNALVSVFLRVLEYYNGLLFLTTNRVGTIDEAFKSRIHLSLYYPPLDKTQTRDIFRLNIGKLKQIEAERHRMTGEPALVIKENEIIDFAAKHYEELARSTGCWNGRQIRSAFQIASSLAIHNYANQAEAARSRGQSPPAAPVLDRTWFEKVQMSTQSFDRHMKKEAGSYDSEMPMRSTFQESKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJJ6</accession>
    <name>S0EJJ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to CCC1 protein (Involved in calcium homeostasis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434611.1">
        <property type="nucleotide sequence ID" value="XM_023582014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJJ6"/>
    <dbReference type="STRING" id="1279085.S0EJJ6"/>
    <dbReference type="GeneID" id="35405867"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12411"/>
    <dbReference type="HOGENOM" id="CLU_038957_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT72533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="273" mass="29867" checksum="079A36FE53DEE663" modified="2013-09-18" version="1">MTHITSESTPLLPEPATERSISYQSSHPAYDARPLHPNYSKHEECHVDYSDILRDIIIGFSDGLTVPFALTAGLSSLGSAKVVIIAGLAELFSGMISMGLGAYLAAVTERDAYHSQAGKKEFAVQNRPGDERTGVYDVLEKYSVSRTAAAPLVDELCKNPTEWVRFMMDFELKLEEPNVHRAWISAVTMGLSYFIGGLIPMIPYFVMSRVREALFVSIGITVAVLLVFGYVKNYVAIRNHRAGVWGAVQTLIIGMLAAGTSYAIVRGLDSNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJN6</accession>
    <name>S0EJN6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437294.1">
        <property type="nucleotide sequence ID" value="XM_023570140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJN6"/>
    <dbReference type="GeneID" id="35404724"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11262"/>
    <dbReference type="HOGENOM" id="CLU_2158608_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="111" mass="12446" checksum="F402A771C414CB0C" modified="2013-09-18" version="1">MPQDVYVRFANGLGDGQQLNITVYYQMNGSDTVYQKSISLNGPGYEVVHLNYIQRVVMGGLTANVGLNSSAFDGQPDAAYFTTRMSDASDGRHYRLQWESGGVSRETWYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJU8</accession>
    <name>S0EJU8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436998.1">
        <property type="nucleotide sequence ID" value="XM_023569841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJU8"/>
    <dbReference type="GeneID" id="35404458"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10994"/>
    <dbReference type="HOGENOM" id="CLU_023464_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6546" evidence="2">
        <location>
            <begin position="295"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="528" mass="61473" checksum="D2463E31DAAAD388" modified="2013-09-18" version="1">MSHSYCINFIQPSVQSAPPQATQSTAPVGTTTRWNRLPREIQHYILDFLSHHYRGRHVYASVCREWRTFMEERIFHNLTVCQHGLASLAQLSAQPRAAIQHLWFNMELRGPVCRECFTANTRQMPTINGAVAQLMRLSEYYLYQLFSTLSSWDCTERGLTLEFNAYSVREQAHWLKNWFIGCPGESQRIPVLTIDPSHDWRTVALASVVRAIATCFRPIRLNNDMKLPLADAVTKFVIRRYYRNRFRPSDTARLVNACPRLVHLHLETWAYSDAKFITSQNSNSRQEYDLIANIHPTTLRTLTVFEDFCKEHLLLAPLFHGPRCVYVQQQRWVDENSKQFAARSLNLQHLSISFMAEAESFFSHCQSSWTWKNLQTIVLTTRRFNRHFKPQAVSVLLQNAAQVALRMPSLEIMVLWSASRKHHASSFTYRRTKTVATIAWCSTEDLEFDRYTVQAWEEVARKHGHPYMWSEKSKQLERGDIISHGHAIRLLELSTLVIDPESREQIEKEYEVAGPGIHQTPLVFHRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK76</accession>
    <name>S0EK76_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase FCK4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437454.1">
        <property type="nucleotide sequence ID" value="XM_023570326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK76"/>
    <dbReference type="STRING" id="1279085.S0EK76"/>
    <dbReference type="GeneID" id="35404890"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11428"/>
    <dbReference type="HOGENOM" id="CLU_024469_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="56995" checksum="13CF380A2969740F" modified="2013-09-18" version="1">MSSNMIDRLRSKKSARSLNDKDKVLRKLSPVEHLQAAHYSLGAIIGCAISCRYRIPGALLATDAASFQVVVENAFARAILMHPLFTVGRINADSKKQYWVRLDQIDLSKHIEWRTVSDQDSYESVLHATLEWQVNEPYTNLETQPGWRATVLKPAESNFIDVIFAWEHTAADGKSGKLFQASLFTCFNTQDDGTVILKDRIFEVPNTEITPPLHHLIKLPVSLHFIVGEFGRDIIASIKAKELPHMATWAPIPTEPSTTRMVATKVAKSALKPVLNACRQHETTLTGLMHALIAVSMATRLAEIKASAFLCGTPVCLRQFQKPGHQSIDMNKTAINSVAYWPFTFDKELVAKVREQMNEAQIKPNMSTNLEETVWSSAKAIRDGLSAKLDLGTKNDHIGLAKFVKDWQSFVKDHGKTRSYSWEISNLGVIQGKADGEGDKWAIESATFTQTAPTFGSALTFSVISAQGGDLVITNTWQVGVVEEELALGVSSDLEGWLNELGSTGSINFAKGQMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKD2</accession>
    <name>S0EKD2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_14422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434941.1">
        <property type="nucleotide sequence ID" value="XM_023582401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKD2"/>
    <dbReference type="STRING" id="1279085.S0EKD2"/>
    <dbReference type="GeneID" id="35407870"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14422"/>
    <dbReference type="HOGENOM" id="CLU_018204_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF15">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE APDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="156"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="266"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT72863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="462" mass="50812" checksum="97DC26075BCD0679" modified="2013-09-18" version="1">MAPQIPLAEPSWLRDLPSPFYKESHFRFQRACRAFISENLHKHAIEWERNGDVPEDLFATFVKGNFVLPALPAPLPVKWLRQLGINEMPGGVALEEWDTLHCMIYSDEMNRSGLSGPSGSISAGMAYGVPPLIHYADKQLQERLLPDLLLGKIRSCIAVTEPDAGSDVANITTTAKLSECGKYYIVDGSKKWITNGIWADYATMAVRTGSQGSGAKGISLMAVPLANTEGVTRRRMKVGGGVTSGTTYIELDEVKVPRENLIGEEGQGMQYIMRNFNHERMFFGVGITRQARVALSTAFEYCLMREAFGKPLTGQPVVRHRLAKCAAMLESHTAWLELLVYQLSHMDKAEADRQLGGFLALSKANAGMVLDECARCAVLLFGGKGYTRTGQGEIVESTSLLPNLLDLETNMRYLTAIYREVPGARIPGGSEDVLLDLAVRQLIANFQAETRALKAKGKKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKL3</accession>
    <name>S0EKL3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437422.1">
        <property type="nucleotide sequence ID" value="XM_023570288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKL3"/>
    <dbReference type="GeneID" id="35404857"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11395"/>
    <dbReference type="HOGENOM" id="CLU_109450_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="220" mass="22670" checksum="197AC85A1D18EC0E" modified="2013-09-18" version="1">MSSALVTSLPIFAGAGSSQTLVAEVLGADADHTTYVLNCPYVDPESEEFQTMDDCGVYNNTYIIGPYMSKTLPPGAASTGDFDLFITMPGDAEDDWKFSVHCKMSRTVAQKCTTVNIGGNDDGHPTATLTNTDDLEDYGFRTFDYGAVSITAGQDLLDAKHASATATASDATKTKASGNDASGSETSGAATPINTSGASSSFTRAFGALSLAGVAAALIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKQ6</accession>
    <name>S0EKQ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436560.1">
        <property type="nucleotide sequence ID" value="XM_023569333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKQ6"/>
    <dbReference type="GeneID" id="35404002"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10538"/>
    <dbReference type="HOGENOM" id="CLU_1288996_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496097" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23821" checksum="1DA6F935CA708116" modified="2013-09-18" version="1">MSRHLLLLIAFAIVLCNASTITNYWGSHNCQGSYHRCYNRRAGQCCEDNETFRSAKFGGLPKGPKTCVTNDQDPHEYCGVSQKAILTFKRTTCLTGNGYAWSGGSIFFDCNYIREHMCLSDRGLEHSEAMPDRETKLPDIKCTSSHKPDVVGAHGYEFFVYGTDLAKKYGKVALNDEETNEILALVNGSSETSLEDLLVKFGHSALQEGEIQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKR8</accession>
    <name>S0EKR8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DM13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436570.1">
        <property type="nucleotide sequence ID" value="XM_023569344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKR8"/>
    <dbReference type="GeneID" id="35404011"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10547"/>
    <dbReference type="HOGENOM" id="CLU_122006_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045879">
        <property type="entry name" value="B561A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47281">
        <property type="entry name" value="OS09G0557700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47281:SF1">
        <property type="entry name" value="OS09G0557700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485731" description="DM13 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="3">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="174" mass="18545" checksum="EDF46825909707D5" modified="2013-09-18" version="1">MAFKLAALLFASAAMAAKMGDSGALSSLDAGLGGTVEVVSDTELKITDYELKDASAPALYWWGSKTEDLSSGFRINKERIGDTSSKMDIMVKLDAGHTAKDFSYVGLWCEKFDANFGQAKLTSDGGSMNSTDEMDTKKDDMKKDEMNSASGCPTGQPAMVVAILSLLAFSVYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL35</accession>
    <name>S0EL35_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable VMA9 Subunit e of the Vo (Membrane) sector of the vacuolar H+-ATPase, essential for vacuolar acidification</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_12265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435161.1">
        <property type="nucleotide sequence ID" value="XM_023581849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL35"/>
    <dbReference type="STRING" id="1279085.S0EL35"/>
    <dbReference type="GeneID" id="35405721"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12265"/>
    <dbReference type="HOGENOM" id="CLU_170555_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="74" mass="8192" checksum="F2CC808D9A06F5A6" modified="2013-09-18" version="1">MAQGYAVFIGLVVIAALCVASWFLAPKGENQVLWRSSAILAIVSCYLMWAITFLAQLHPLIAPRKSGIREEHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELT6</accession>
    <name>S0ELT6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437603.1">
        <property type="nucleotide sequence ID" value="XM_023570499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELT6"/>
    <dbReference type="GeneID" id="35405045"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11584"/>
    <dbReference type="HOGENOM" id="CLU_099905_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="231" mass="25419" checksum="2BD068BCDDB5C9D2" modified="2013-09-18" version="1">MKPSNTVFQVDFKWKKMKALVSEKDPETNNTTPKYIVDYHAFKCTSLVFHPYDDPTAVIGTGTLHPVTIHATYELHGQKGTIKALKRFMTSYTHLSYNYSSSPDGTPAAMTWASASSFKTWDFVCLDEQDSAVAKFSANCWSLNNVGCVEFLGSKANDPAAREEILVTGMTLFYQMVLRATNVLSLGGSIFARPGPLDKEAAPKRPMQNADGKSIKELEATSGMEPGLEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM08</accession>
    <name>S0EM08_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to myo-inositol transport protein ITR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_11016</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437020.1">
        <property type="nucleotide sequence ID" value="XM_023569866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM08"/>
    <dbReference type="GeneID" id="35404480"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11016"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="79"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT74942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="574" mass="63901" checksum="BB271E09FBBC4943" modified="2013-09-18" version="1">MGKSRQNSTTTVDREKDEIQKAMGHEKAEFEALEVARHGGREIDELIDDMERQLDESGGLKKGFFQIQFANPKHFTWLLVAFASMGGLLSGLDQSLISGANLFLPDDLGLTEHENSLVNSGMPLGAVGGALLLSPANEYFGRKGAIIISIILYTIGAALEAGSINFGMIVSSRVILGLGVGLEGGTVPVYVAETVERRIRGNLVSLYQFNIALGEVLGYAVGAIFLNVPGNWRYILGSSLLFSTIMFFGMLFLPESPRFLIHQKRHLDAYKVWKRIRGIEDRESREEFYVMSASVISEENAVAEGAKNHRFPWMDFFTEPRARRALVYANIMILLGQLTGVNAIMYYMSVLMNQIGFDKKESNYMSLVGGGSLLLGTIPAIFLMERFGRRFWAITMLPGFFIGLVLIGVSYQFDVKTQLQTVEGLYLSGLIIYMGFFGSYACLTWVVPSEVYPTYLRSYGMTTSDALLFLASFVVTYNFTAMQNAMGRTGLALGFYGGIAFVGEIYQIFFMPETKNKTLEEIDVVFSRPTMDIVKENWAGVKETTHLLLTGHWHKVFVEQAMTDPKDQVQVSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM83</accession>
    <name>S0EM83_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438199.1">
        <property type="nucleotide sequence ID" value="XM_023571138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM83"/>
    <dbReference type="GeneID" id="35407668"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14216"/>
    <dbReference type="HOGENOM" id="CLU_1796629_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT76153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="144" mass="15575" checksum="1DE628A24BB3CA8F" modified="2013-09-18" version="1">MAPEVASTVLLSNTRALGSHMARDSQALTYREERETIQLPSADIFDQNALPGGRLYFVPRFFSSGLVILRYAISGASRVPISLANVGGTGSDACSNETPEKQASSEPDWYIIGTNVLSAERVTRQQMQSLAKAGKLLSEALRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN00</accession>
    <name>S0EN00_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438068.1">
        <property type="nucleotide sequence ID" value="XM_023571055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN00"/>
    <dbReference type="GeneID" id="35405543"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12083"/>
    <dbReference type="HOGENOM" id="CLU_020986_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT76022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="516" mass="56365" checksum="189B3EF61910327E" modified="2013-09-18" version="1">MVSAITPPPSSAPPYRLANLANLTLGYTVYPSWTQKDGPVAMTSPPSPPYHDDSLKAEHYPLIINNALYTPPGVYSVRQLVATASPLLDVIISRLGPDGPNDVPARTVLVNGLAASLATTGRESTLPLVHSSQDTARREIVIQANKIAKTLVAYVHDSIDPINANPKIRLRSPCEGHLWTPAVAGLLLGPRSDSQLMELYNEWLHRMILLRDSLIPFENYDKVPFVIPRDSDRGIRDLEEPRKLFLVHCLTGTIQHVAIVDLAKVFTARHLPRGGYGFQYSQGLVLPAFLSGSTSLHLLRYHPAHVYDSESEVLFDYEHKEYIDAPRTELAASEAVSGDGSWNLPSLLGVDTRVTESSLAIDAGKDALRRIVKLRLTLYSGKSVSVDLGQIARGRRYAYEVRAEKGSTNAKSSPILSALSAEGGNGIHKTIIHDAADILSRPGLVISPRVKDGHGNTIHIIPTSDPILKLALLGKFYPENVILSREKDNIDALSKAGKGFAERLVILDRINEKAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN52</accession>
    <name>S0EN52_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_11690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438113.1">
        <property type="nucleotide sequence ID" value="XM_023570616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN52"/>
    <dbReference type="GeneID" id="35405151"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11690"/>
    <dbReference type="HOGENOM" id="CLU_008003_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="NXPE C-terminal" evidence="10">
        <location>
            <begin position="67"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="9">
        <location>
            <begin position="330"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT76067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="848" mass="95347" checksum="763D4075CE3B1C99" modified="2013-09-18" version="1">MGAALPTSGVALNRVLALGLTLVVILGIAINQLQLSDDPYRCKALLNDGSWLNTPAENGSRAPFTNWQPPGCMIHKYKKEEIEECMEGRHMVFVGDSTTRQVFYGMARLLDAEKAEEVRANSKKHESHDVEFGGIRLKEIWDPFGNDSAIARNELTLYHEERINEVPVEEQKGPALAFMGMGVWFAARFEKEESIPMFKAAFNNMSELASNMDFEPFGNRPMDPRDGIGNEVFWAPIAPPFYDMLPDYRKTGVASQPGEVEEIDEFLKTQEQESGIPMLWSFPALSYDQQDAIGDHENGFHVTDSVAEMKAQILLNLRCNARLDIQKSYPYDRTCCTDYGQKSFVQIILVTLGILYVGGAAITEILALRSGEAPKWAIFNLDVATFVTGVLACYWADRTQSFAKGSKEYSMFDFNLMSALCFIVGFAFMTKSKPPPPRPGAAPAAAPATLDDAKPLSRDQTDEWKGWMQALILVYHWTGASRDLNIYVGIRLLVAAYLFQTGFGHGVFFSSKKDFSFKRVAAVLLRLNLLSCALPFFMNTDYMFYYFAPLVSFWFLIIYALFAIGQKYNDNTWALMGKIAVSAAICPGAMLYTPVLQWVFDALNIVFRIEWDLHEWQFRLGLDGLIVYVGIIMGVASVRTKLYNKILTQSYGLAGVAGILSIPLYWWIAVSSAESKQDYTALHPVFSFIPIMGFIAARNMFPAARTWYSRTFAWIGRCSLETFTLQFHILLAADTKGLLLLDIFKGDGSLLCDRWRSLIIIVPVFLWISSRVADATGGMVKLLTKDWAAQEQEEQYDVEAKADAEPLMSGNMLSGFTRHMPSKSSWANNLKLRMLGLFVLLWTLNLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN83</accession>
    <name>S0EN83_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to ADH2-alcohol dehydrogenase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_11440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437465.1">
        <property type="nucleotide sequence ID" value="XM_023570339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN83"/>
    <dbReference type="STRING" id="1279085.S0EN83"/>
    <dbReference type="GeneID" id="35404902"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11440"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="7"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT75419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="337" mass="36144" checksum="49369E98B2BCB89E" modified="2013-09-18" version="1">MKAIQIKEFNAPYTVSDVDKPKPKPHQLLIQIKAGGFCHTDCMALENAFGSKLPFIGSHEPAGVVVEVGSEAQGFAEGDRVGCLNFDSCCGRAGRPIYCDNPSMKGITTDGAWAEYMAADARFTVKLPDSLDFLTAACMMCAGITVYGGIKRAQVPSGGSIGILGIGGLGHIGTQVAKAMGYQVAAIDVKQDALDLVSSYNLKPDVCILSTDPAETSMEKITNVIQGDYHGLDATVIATDAPAAFDLAAKLTRKHGTMVLLGQPEKGITLSYQNVIFRDIKLVGSLVADTDETEELLELVVKHDIKVKIKEWKPEDAEKMRQEYLAGRNSGKNVIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENS8</accession>
    <name>S0ENS8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436421.1">
        <property type="nucleotide sequence ID" value="XM_023569169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENS8"/>
    <dbReference type="GeneID" id="35403856"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10391"/>
    <dbReference type="HOGENOM" id="CLU_1061913_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="262" mass="29338" checksum="D943D18B1720762F" modified="2013-09-18" version="1">MKPTNAILSVLASQATAQLIDIQIGDTARLDIMRQAAEAQVNGNTAKAHALMDQIRIADAAHEKSLWKIDCRVSSQFEAEIYTVQDPSRAPKEIAWAMDFLDNHWKTDDGRDLPYPGDFDRFMHPDGFRVMRMDYKKLPWAVRKYHEELVKEGKQMERKFIAEIDGSAFFAPGVVTWLAPLFAGSKIEPGKDTCEDDLVDFGNWDKKKQAAEGARYTFGYGGKVQIGDHITVEVHAQRSSKQGAEKEAVTGGDEDTEGTEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP64</accession>
    <name>S0EP64_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to ARCA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436771.1">
        <property type="nucleotide sequence ID" value="XM_023569575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP64"/>
    <dbReference type="STRING" id="1279085.S0EP64"/>
    <dbReference type="GeneID" id="35404219"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10755"/>
    <dbReference type="HOGENOM" id="CLU_008719_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF25">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="537" mass="60344" checksum="844A54DF6C4B71BD" modified="2013-09-18" version="1">MGRRSQYTAWYTASSLQAFLGLPCSNCTKSQRECKAGSFFLFRPGIKSKTSKTSKTRDKSRRNRNATLTLAETNSDTVKTSLPSDTDSHPVSTSSGVSRALALIQEQTSLPNSIDNDQTYQNPINNPLSINEFLCSETDGTLPSGDCTTPPFIVKPGSLYVDRPVAQAIDYRAAELLLHFKTVIAKPWFEVTDPGFTNEALRRAPRCPLLLYSLLAVSSSHKSRFLDDPDIAQDYARYGEEYHEKCISLLLPMLNDSESITDGAFLACSTILRWYEELSAPIHGRDDARHLLGGYASVTESFEQDLTWEGFRGAALWIHLRQDIFNAVINQRVPRTNVKELEIDRSSSPADETIWAKRVLCLEAEVVEYCLGGEGSSIQQYKALEARLEDWDSQKPQTFTPVLYQERDPSQGVSFPVVSVLLDSCVFGLSHYYFAMLMMLVHDPRMPKVGTQYLECQKEIRIRILHFLRLLCGLASSSPVPPARGMTCLALSLFGSWITDHAERDAAINVLRKVDREDAWPTSSLQRDLQAQWENRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPB2</accession>
    <name>S0EPB2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436896.1">
        <property type="nucleotide sequence ID" value="XM_023569723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPB2"/>
    <dbReference type="GeneID" id="35404352"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10888"/>
    <dbReference type="HOGENOM" id="CLU_061199_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF3">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="261" mass="30146" checksum="5EBAA80A9A8B45C4" modified="2013-09-18" version="1">MRFLTDSRGLGDPNSEEVPLLVIGAGLPRAATSSMQAAFEKLGCGPCMHMAEILPHPSRLRLFIAALREKNPEVRQKMVKQLIHGHRSICDLPVVYFTPDMMDAYPDAKIVLNQRPDPEVWAKSAEESFWFFFSPWFYWVGLLWSSDRMWYTLNMESIKLGKEKYGSAEIFSAEMYNKYNEEVLAEAKKRNREVLQFKAEDGWEPLCKFLGKDVPSEPFPRLNEKKTFQIVKYVFIAKGVLSWVALFGATWGLWKVASWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPB5</accession>
    <name>S0EPB5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_10898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436906.1">
        <property type="nucleotide sequence ID" value="XM_023569734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPB5"/>
    <dbReference type="GeneID" id="35404362"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10898"/>
    <dbReference type="HOGENOM" id="CLU_000960_27_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF36">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="88"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT74828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="574" mass="61503" checksum="B379ED7B2FE756AD" modified="2013-09-18" version="1">MAQPSIPSSPVQRFPSHPSTKPAVPSRGCSPRALAQGVDLPPNNNPSPDLHDTTASLSVADESLQARIERLGRERPPIFTTRWSEIIFVFSISMSQFLTEYFVSGFTVILPTLIRELDIPQAASVWPATAFSLVIASTLLVFGRLGDMWGGYPVFIWGLAWLLIWSMIAGFSINPLMLDLCRALQGLGAAAFLPTGVMLMGSLYRPGPRKNLVFAVYGTSAVFGFFGGILMAGIVGQFTRWGFYFWNGAILTAITLLTSILSIPRPHLEGQPPNKVAMDYPGAITIVSGLTLVVFSILQSAHAPSGWRTPYIPLCFGLGVLSLLAAVYIEVRVATHPLLPASIFTTPCMSPLLLALFLLYGTWGIFSVYGTLYFQNIMSASPLQVVAWYVPLGVAGLIFSIIEGFILHLVPGRVLLIISGLGAVGSQILIALIPPGGSYWAWVFPAVIFSTIGIDLSTILSTVFVTTSFPTAQQGLAGSVINSVLQLGVAFMLALTDIIESATVNEAGLAKSYKNTFWFGVGAAAASLLILAIWGKIPKASSDLTADERAELPEEAISEQRRNEGSNGSTLGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPN7</accession>
    <name>S0EPN7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_11492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437516.1">
        <property type="nucleotide sequence ID" value="XM_023570397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPN7"/>
    <dbReference type="STRING" id="1279085.S0EPN7"/>
    <dbReference type="GeneID" id="35404954"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11492"/>
    <dbReference type="HOGENOM" id="CLU_018354_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="68"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT75470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="500" mass="55076" checksum="D5DEF8592DC3DAB2" modified="2013-09-18" version="1">MEFIAAGASWALGKAPSPQKILGRLGLASLVAQNSWPELSSKLSPQASIVLPDESSFSGLVSRWRDWHGPQPGAVVRTFSESDVQETIRYANEHGIPFLARSGGHGATEALQLAKDVIVVDLRDQNDVEIARDGKSARIGGGASVKKVVNELWTAGKQTVTGICECVGVSAPVLGGGHGWLQGQYGLASDQVISARVVLPNGDAVTASEDSNPDLFWALRGAGHNFGIVTEWKYRIYDINNPMWSYEIFIFLGDKLEDVLELTNKMMKTQPPHLTHWIYIVNIPEIDPDKPIIWYAVISDGAAQKARDYANPLHGLGPINVNAGEASMPDLAAITLMGDDTVGCAKGFTGLRYPIGLKTYDLFAVRKVFNEIADMSKRVPEFAGSFFLLEGYSTHGVKAIDAKDSAFPHRDDEILVTPYILYKPNATLDGLAQEHGEKLRRHLLEASGDPEHLRAYVNYAHGFESLEEMYGHEPWRIEKLKALKKKWDPENRMRFYAPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ32</accession>
    <name>S0EQ32_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-dimethylallyltryptophan N-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.261</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_14172</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58209"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:67248"/>
            <dbReference type="EC" id="2.1.1.261"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.261" evidence="8"/>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438241.1">
        <property type="nucleotide sequence ID" value="XM_023571187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ32"/>
    <dbReference type="STRING" id="1279085.S0EQ32"/>
    <dbReference type="GeneID" id="35407624"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14172"/>
    <dbReference type="HOGENOM" id="CLU_049766_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="10">
        <location>
            <begin position="38"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT76195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="329" mass="37902" checksum="C55E430E64F92D37" modified="2013-09-18" version="1">MGQVLNVGGGKLQSYNKALLEKKLFWTQGPFTTLTNHVQRVLPTSIIYGDKGLELWASITHLPSYYQTRGEAALLIENSEDLARWIQKESVLIDLGCGDIRKLIPLLEELDRLQKPVTYCPLDLSHKSIERAMEQTRVSLLPYISVTGLWGTFEDGVEWANRACVDRPRVFLALGSMLGNDHFEDAVERLKWLRSTGLRNEHDRILLTMDGTKDMDKICKSYDDVGGLFTQFIRQGFENSNHVLGNNWYRHEDWSLQRRFTDNPTMHRFVLKANQGIECPTMNVKFREGDEIDCYEGFKYGPEDMARQFKAAGIREYARWKGPEDDICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHH5</accession>
    <name>S0DHH5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to 3-oxoadipate enol-lactonase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423630.1">
        <property type="nucleotide sequence ID" value="XM_023569862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHH5"/>
    <dbReference type="STRING" id="1279085.S0DHH5"/>
    <dbReference type="GeneID" id="35395454"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01971"/>
    <dbReference type="HOGENOM" id="CLU_020336_50_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="285" mass="31136" checksum="2D016EE1D5305415" modified="2013-09-18" version="1">MASSLTLPDSRTLAYALDSSPKEGPLIILSNSLTAPLSVWDHVVKVLNSNGYRTLRYDQPGHGGSSAPKDLSPTFDSMAEDVHHLLKKLEINKVYSWIGVSMGASAGVYFTTKYPNVVSKLAICDTISSSPINAGTEDAFGPRVAAAREAGNLDATIQGTLERWFGKEWLENNHQETQRMRTVMSGTTIDGFEACCNALRSETFDLRPRFAKIGSSVDDAICIVGEKDANLPETMKEMRDKIQEGFEAAGKSNKIDLVIIKNAGHVSFVDGFEQFTAEVLKWLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHX9</accession>
    <name>S0DHX9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_01895</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423697.1">
        <property type="nucleotide sequence ID" value="XM_023573617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHX9"/>
    <dbReference type="STRING" id="1279085.S0DHX9"/>
    <dbReference type="GeneID" id="35395378"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01895"/>
    <dbReference type="HOGENOM" id="CLU_053731_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="227"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT61616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="382" mass="43546" checksum="FE33A54B462D9F20" modified="2013-09-18" version="1">MERPSTPPRATKPAPTITPPTPEVTKRIEENRLRAKAIRDQREAEQRATGTAPEIPKSSGGFVPTKDVYISKTADGKRPYSSISTEDASKGTNRDGRHKGDEEALRPARKFTKFVDYNMSAMTDTKGGFLSTEDDPHNYALGGKKPGQSEDDQRPKHMSVQEWERLQLIRNLKRLKAGPFEPGLSVLADNETRKKCQDCKSLEIDFVWEEVFHIGVCNKCKEKYPEKYSLLTKTECKEDYLLTDPELRDPELLPHLSKPNPHKSHWHDMMLFLRCQVEEYAIKTKWGSSEALDAEYERRETQKKARKEAKFKEKLLDLKKKTRTDAFRRQAGNLSKSGASKFGDAIGGGRHVHEWGRTVENEDGMTVKTCVDCGMEVEELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI47</accession>
    <name>S0DI47_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423802.1">
        <property type="nucleotide sequence ID" value="XM_023574739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI47"/>
    <dbReference type="GeneID" id="35395279"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01795"/>
    <dbReference type="HOGENOM" id="CLU_2306377_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="100" mass="11100" checksum="0749B27A3969D95F" modified="2013-09-18" version="1">MPDKLAQPMGYDRPQALEFNISELVLERAPPPDQPRGVAAAEPAQDVLDYIETDNEYAPVDYMIATSKELDLSVAISYQETLGLVLESTPNIVHQIQVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI56</accession>
    <name>S0DI56_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to hormone-sensitive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423817.1">
        <property type="nucleotide sequence ID" value="XM_023574907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI56"/>
    <dbReference type="STRING" id="1279085.S0DI56"/>
    <dbReference type="GeneID" id="35395264"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01780"/>
    <dbReference type="HOGENOM" id="CLU_003590_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="220"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="451"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="739" mass="83558" checksum="CEBF91F46F507F60" modified="2013-09-18" version="1">MIDHVLGRPSVKSRRLQVLAVLTFWSAYLVKGHKHGPPGAQLLSRLFSKRLTAWQTVVITMIYLYAARNFSTLVGLASPEPLANMYDATYYRATWVLTALDAGFWTAMKIKTKWLRDMASIVFSLFYLVAAEKADEKVRKVRGMITVEHLRVSWNKGTSPYLSFFQGLMRPRFMRWPPRQIRIPRPADSDYKEPVLAWLYYDGPLSDLHRHDRLILDIPGGGFVAMDPRCNDDKLFSWAAKSALPILSLDYKKAPEFPYPYALNECFDVYRTIVNTKGRCIGLPGTEVPRIIVTGDSAGGNLAVASTLMIMETRHSAFRRPGQTELPAPDGLVCFYPALDMNIGNWMTDEQMSLIKDRKARKTNRRIMRRKSMQYNELVGTPHHSDDEEDGSPPPHTKLSALTTKEALIAASQGPRSPHPEFSHVGPRSLSFPKDASETDEKKSSHHPEPMKTRLATSSMISYFNDRVLTPEMMRAMIILYIGAHNRPDFSQDYLLSPVLAPEALLVDFPKTYFMTGERDPLVDDTVIFAGRLRRAKEAAFVQEQSERHKNAEFNDRDAAEVMLIPGTSHGFMQFPTVYPPAWRHFERCIDWFDQLFDHAEVMRVRKDRQARAARSQTNGFGINGDGRHHMRTESSEEDRPLEISMTKMNQRRSSNQTTPQQSPDLNGGSESGDTTPRAHTNGTSLSNGDKNAKRRKSVGLSKSKNRNKSLVKLKSSDDLLGRRMQGLASGLTGMGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJJ4</accession>
    <name>S0DJJ4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_00950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424576.1">
        <property type="nucleotide sequence ID" value="XM_023569363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJJ4"/>
    <dbReference type="STRING" id="1279085.S0DJJ4"/>
    <dbReference type="GeneID" id="35394435"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00950"/>
    <dbReference type="HOGENOM" id="CLU_003637_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000470">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="109"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="286"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="668"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="870"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1096"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="870"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT62495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1194" mass="134828" checksum="16A85B50DDE0CBA2" modified="2013-09-18" version="1">MDGDEPTQATQNVLDPRRVGKQNSGFSDEDISDIICVLYPHSDSARVELERLVGENSPHIIGKDEADGVEPDYALEDQAARFLANPTGTGTHAIILRLSSHLKNPKAGFVFGRNPVRCDVVFVNDPLKRISNIHFRIYVNEYGTVMVEDQSTNGTIVDDHLLTSHPQAKGRSDPPISKWVLSSGSIIKIYLHKEARDLTFRVRIPRRDNEYDQAYTDKVDDFFTRHGLPRQNETITPGPGGHVDLFKQPAQTNLKREETNEITQRTPQTLSKRRDAPREWTGSGKYNRTGSIGKGAFAVVHRVTSKYDGLPYAAKEIEKRRFIKNGVLDQKVENEMKIMQRVKHPHIVRYMEHFEWDDRLLIIIMEFVPGGDLGKLISDQKALREDVVRTMSGQLLGALGYLHANSITHRDVKPDNILINSLNPIDLKLTDFGLSKMVDSEQTFLRTFCGTLLYCAPEVYTEYAEYDDDGVRSRGKKMRRPPGQRYNHAVDIWSLGGVLFYALTASPPYPVKSGISYSELLHKIMTTRLNIAPLQRNDVSEQAIDFLCRMLQRRPENRATVAELESHPWSSGEDSIINASQSFDEISDDDMFDNFSQLQPKQYEEDRVSDSMGEESEKETPTVPLEANQPRLFGEVGVSAIGSSGVIPEDYLNLENSSNPSADETEILRKDEDEAYQSDDLVTPRNRNRRTYRQNNISMAQVQSEDQLQSLVEDVASQSLGGNEPNLQNPGQSRYSLQSVDFNTSKRKPSSYDTSDEFDNTPQGKPTMKRLKSEGNIEDLANDVLEEYKLLVQVPSAEKQASGRQIDTPYNKTCFWEQDKTTWHFDYPELTHLQHKAFERGAAARNEKFEPGKSPLWDLAMKYFSPVSKAGSQINQARRSSRTPQDTAADEPLDFPPTAAPLENSQIPDTLPTHTQIIVPVQEDEPNRRAIGVLESHHESCVPGISIPIKDTLVSFGRGPANTVVFRDIQESRVPKYAFKLLLWKEDGTFDPSKDPDKVPPPWLRDAGDPNEYGFYISTKASVGISINGYQLASSDAKNHSGPSHHWARIWNGDTVMIWGDRKSTQTKLVFQCFWGASSQAREGNQGLQLASPSLSQKLDIACQKTEKRIKEATEKKKIKDAINADLRERTENIEREQERSRAFEKKRKEAIAYLDSRQTPLSRMASPASALGTSNYREPMMFRLSSDNNLSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJR3</accession>
    <name>S0DJR3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to salicylate 1-monooxygenase (Flavoprotein monooxygenase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_01994</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423608.1">
        <property type="nucleotide sequence ID" value="XM_023582116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJR3"/>
    <dbReference type="STRING" id="1279085.S0DJR3"/>
    <dbReference type="GeneID" id="35395477"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01994"/>
    <dbReference type="HOGENOM" id="CLU_009665_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT61527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="416" mass="45237" checksum="F53BDB8CE4640DE1" modified="2013-09-18" version="1">MSPACQHRILIVGGGLGGLALAQGLKHTSPSVPFHIFERDSSADFRPQGYRIRINPDGAGALRKLLPDNLWKAYENTCALFNPAMSGLDAVTGQKPTPSGERRGPPPMPEGKYYNADRVVLRNVLMEGLEDDISFGKTFKSYRVTSDGVEVTFTDGTKETGAILVGADGTRSHIRRQLMPNYTVLDTECGAIYGKTFTKPETRASMANEFFGGICLAGDGSKPGLKLFTDTMEFPRDLSLDERAKYRVPDDYVYWVLCINRPLLGIAAEDLHGLDAAQSVETTLQMTKSWHPTVRSLLQKQEQSASSTLAFFACLPETFKREWDELVKSPDCAAVTLLGDAAHPMTPVGGVGANSAFQEAADLCSVITRASFGAEALKDYAKLMTERGEETVGLSGGGAEHMFQMKPFSELKVASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLD2</accession>
    <name>S0DLD2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable BRT1 protein, down-regulated by mating factor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425500.1">
        <property type="nucleotide sequence ID" value="XM_023582139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLD2"/>
    <dbReference type="STRING" id="1279085.S0DLD2"/>
    <dbReference type="GeneID" id="35394617"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01132"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="125" mass="13643" checksum="7C0848D4E8A7EE40" modified="2013-09-18" version="1">MSSDQQIIFTKDAPAALGPYSQAIKTPNMVYCSGQIPLTPEGEMVQGITEQTRQACKNVQAVVEAAGSSISKVVKTTVFISDMSYFAEINTEYEKWFSHKPARSCVAVKTLPKNVDVEIEVIALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLD6</accession>
    <name>S0DLD6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425312.1">
        <property type="nucleotide sequence ID" value="XM_023573622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLD6"/>
    <dbReference type="STRING" id="1279085.S0DLD6"/>
    <dbReference type="GeneID" id="35393628"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00143"/>
    <dbReference type="HOGENOM" id="CLU_866100_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484679" evidence="2">
        <location>
            <begin position="17"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="326" mass="32388" checksum="9FC627A83C9C685B" modified="2013-09-18" version="1">MLFTPLILLLPAVSHASWLPVRLPIRRGQLPSPEDCTVTSTLSPITVTSLHPTSTFGPHSSGSGSGSDGSDGSGHGQVTGGGTIIYTTALSTLGPNGPGVHTYTITAPCASSHCQRPPSTECPPGFTTTAVICHVCGEHPVTTTLTLPIESATAAQGSHGGAARAGSTLTAVVTSVVHKTVVPVSPAESVYPWISRGGPELPDAQKPSQVSGGSDAKHDGAGKGDELPEGPKNTGAPELPAGGGADTSSHSSTVDAPNGASTAAGNEAGHGDGDGDETGSESASPSDDASPSAVVVTGHAAETKVTKSVVLKAVLFAAMVLYPLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMI8</accession>
    <name>S0DMI8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_00878</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424643.1">
        <property type="nucleotide sequence ID" value="XM_023570163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMI8"/>
    <dbReference type="STRING" id="1279085.S0DMI8"/>
    <dbReference type="GeneID" id="35394363"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00878"/>
    <dbReference type="HOGENOM" id="CLU_035750_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT62562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="270" mass="29294" checksum="8726D1A3084B8336" modified="2013-09-18" version="1">MPGFDFSNYNRNAALHARGVPLPKATSTGTTIVGCIFDGGVVIAADTRATSGPIVADKNCEKLHYISPQIWCAGAGTAADTEFTTALISSQLELHSLSTGRKPRVVTCMTLLKQHLFRYQGHIGAYLVVAGVDPTGTHLFTVHAHGSTDKLPYVTMGSGSLAAMSVFETQWKPDLNQEEAVKLASDAILAGVWNDLGSGSNVDVAIITKDKTTLKRNYIKPNEKDPKLQSYRFPKGTTAVLNEKIIKRDEIKRYISVEDVPVEEKMDVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMU5</accession>
    <name>S0DMU5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426000.1">
        <property type="nucleotide sequence ID" value="XM_023571748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMU5"/>
    <dbReference type="STRING" id="1279085.S0DMU5"/>
    <dbReference type="GeneID" id="35398390"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04909"/>
    <dbReference type="HOGENOM" id="CLU_112567_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="153" mass="16064" checksum="EE957ABFD38056E3" modified="2013-09-18" version="1">MATEATVRKFFASSAYAVAGASSNPAKFGHRVFAWYLHHDLPVTPINPGSETINALNKDHPTVPSVTALSNPTQTSLSVITPPAATLKVLQEAKEKGIPSVWLQPGSFDDAVLKFANTPGTFEAVVAGDGGRGHEGWCILVDGERGLKAAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN26</accession>
    <name>S0DN26_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426070.1">
        <property type="nucleotide sequence ID" value="XM_023571831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN26"/>
    <dbReference type="STRING" id="1279085.S0DN26"/>
    <dbReference type="GeneID" id="35398316"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04835"/>
    <dbReference type="HOGENOM" id="CLU_012494_13_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485094" description="Alpha/beta hydrolase fold-3 domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="81"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="301" mass="34065" checksum="3366EBE8597AF3B5" modified="2013-09-18" version="1">MPSFKARILSWIIWWWFKSTWSSAEGINNRIAKERLRPERVPPKHLYKEFAVEEYKRKGHIAHYVVYIVSPKTETPTRGRILYLHGGGFVFDITPQHWELVAQLARRLNATVTVPIYPLGPETSLMKMYEFVQPLHDELASAPDRTPFWVMGDSAGGTMALVLTQNAKLAGRQTAQRIVPITPCTDSSLDNPELHNAALKDPWLDVPGIAEITRLICPEMDTHHPNVSPIYGDLRLPPMLVFAAGLDLLTPDTKKMVEMAKEQGTKVELVYGEGMVHVWPLLPIQEGRQAVDKMVEWLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNJ5</accession>
    <name>S0DNJ5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_00422</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425053.1">
        <property type="nucleotide sequence ID" value="XM_023573311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNJ5"/>
    <dbReference type="STRING" id="1279085.S0DNJ5"/>
    <dbReference type="GeneID" id="35393907"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00422"/>
    <dbReference type="HOGENOM" id="CLU_005015_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000118">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001725">
        <property type="entry name" value="Exo-beta-D-glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="13">
        <location>
            <begin position="13"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="11">
        <location>
            <begin position="195"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="12">
        <location>
            <begin position="684"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT62972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="855" mass="98445" checksum="F4490918777A0596" modified="2013-09-18" version="1">MAPRTVTPIDKNWQFKQGKEDDSSYLPVAQFPTNVHLDLLHHKKIPDPYIGKNELKVQWVGETVWVYKTTFSSPEIHDGAKAVLAFDGLDTFAKVELNGEEILETENMFVPERVAVTKNLKKDGENELRITFDAAYLRGWKLVEEHPDHKYVVWNGDGSRLPVRKAQYHWGWDWGPALLTCGPWRPINLEVYESHIADLYTESEVEKSLKKADVVVQAAVEGKASRVRFEVSLDGKKIASETAHVKDKDATTTFHIQDPALWYPVRYGKQPLYTIKAILLEDDNEIDTISKKIGIRKLELVERELDGQPGTSFFFQVNNIPIFCGGSNWIPADNFIPRIAKEKYRDWVKLVADGNQFMLRVWGGGIYEEDVFYDACDEFGILVWQDFMFACGNYPAWPDLLKSVDREARANIKRLRHHPSIVLWAGNNEDYQLRESENLTYDFDDHDPESWLKTDFPARYIYEKLLPDACKDLHPNAVYHIASPWGGKVTTDPTIGDIHQWNVWHGSQQKYQDYDKLVGRFVSEFGMEGFPDIRTIDAFLPQGKDDPERFSTSSTIDFHNKADGQLRRLGLYMAENFRFTLEPLEDYVYYSQLLQAEALASAYRLWKRQWQGPKKEYCSGVLVWQTNDCWPVTSWAICDYYLRPKHSYFTIKREMAPITIGMTRREHKHPRNKYTRVDIETKVKVEIWGSNLKLEDVTVDCVVKAWDVETGKETYSQTVVSDLVLQSNCSTEIKILDVPVEKPNADLEAKTVVAAYFYQDGKQIARYVNWPEPLKYLHFQKPKNLKSELSEGCKYVEISAEVPIKGLAVLSEDDEVKFEDNLVDVVPGEIVKIGITGAKKGTVLKTQYLGMQVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNK7</accession>
    <name>S0DNK7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426245.1">
        <property type="nucleotide sequence ID" value="XM_023572049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNK7"/>
    <dbReference type="STRING" id="1279085.S0DNK7"/>
    <dbReference type="GeneID" id="35398122"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04641"/>
    <dbReference type="HOGENOM" id="CLU_039466_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="261" mass="30112" checksum="5ABAB683A39D6F7B" modified="2013-09-18" version="1">MSRNKDTVHADARRFLDERGSNVSVAPNGLNPATIMEKAVKDRIVDSYFYKEQCFALNEADIVDRVVEHVNFIGGTYGVTQKPSPFLCLAFKLLELSPSDAVLMEYLKYGGEAFKYLRALACFYFRLTRQAKDVYEMLEPFLEDRRKLRRRGRAGVVLTFMDEFVDELLTKERVCGTSLWKMPKREVLEDLEILEPRVSPLGDLEDLLEEEDEAEKDNGTREESGEISDRGDMEVDRDERRSQSRSRSRSRSQSNSRSRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPS3</accession>
    <name>S0DPS3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425498.1">
        <property type="nucleotide sequence ID" value="XM_023580950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPS3"/>
    <dbReference type="GeneID" id="35394723"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01238"/>
    <dbReference type="HOGENOM" id="CLU_048302_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="488" mass="54069" checksum="85643B6613519367" modified="2013-09-18" version="1">MEDGVTPEPEDLTDWAFAANGTAYEIGLNERRVNNQVIRIRQGASFRMNEAKHSFKNLELHEHHEPWTDEELELEGASPQELVLVVGHCKPDNFKDSDPNHSKWAIAPSVDEFDEQQHKHVRTASTGLVVFWLADTERLGVRLLTLKKRNDSLEFITGRRTDAKTQASLIKRTIMLAAKAAKAHLQLDVPESVSNASALSPNDLSDPPIDAKDSLLSWVQTAIAAYKDTKSFSALEQIHSAVQFAKGSPDTRTYFNETTANHLGVIRQLGQGSMTMNEATRFIDSYTILWPESLSGFSESILLPEKIIQLNDGLAAGALEDIVPTSPRIDDSLYRAFIALFCGASSADNVEAYLKHNIVSAYDMAKMAVGCPCNNVEINVPERADMPVLLITRFMSLLKSQMQSLDDTVSELRGDCQGNIQGESLSIRELTRDLANTVDIDIAKDNVRWILQGMATRHIVLLLGLRNKCAREHDQLSGLLKDYGGGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQG1</accession>
    <name>S0DQG1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_05208</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10 11">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="11"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425723.1">
        <property type="nucleotide sequence ID" value="XM_023571413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQG1"/>
    <dbReference type="STRING" id="1279085.S0DQG1"/>
    <dbReference type="GeneID" id="35398689"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05208"/>
    <dbReference type="HOGENOM" id="CLU_039068_5_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="2 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="12">
        <location>
            <begin position="81"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT63642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="381" mass="43169" checksum="C8FB06BBDA370B91" modified="2013-09-18" version="1">MSSSELISYDEAQNSAFDNVLHRKSKESKGGMRAMINKDNKAHAAAVDEYFQFWDNKKAEDEVEAVRQERTDNYASLTRQYYNLATDLYEYGWSQSFHFCRFAYGEDFNRAIARHEHYLAHNIGIRPGMKVLDVGCGVGGPAREIVKFTGAHVTGLNLNEYQVQRATIYAEKEGLSDKLRFVQGDFMKIPFPDNSFDAVYAIEATVHAPSLEGVYSEIRRVLKPGGVFGVYEWLMTDNYNNDNLEQRRIRLDIEQGDGIAQMFKIDHGLSAIQAAGFELLHHEDLAATDDGTAPWYWPLDSNMRYAQTIGDFFTVLRMNKWGRLVMHNVIGALEACWIAPKGTRKTADSLGQAADALVEGGKRKLFTPMYLMVGRKPKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQG3</accession>
    <name>S0DQG3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_00614</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424879.1">
        <property type="nucleotide sequence ID" value="XM_023573096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQG3"/>
    <dbReference type="SMR" id="S0DQG3"/>
    <dbReference type="STRING" id="1279085.S0DQG3"/>
    <dbReference type="GeneID" id="35394099"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00614"/>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT62798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="449" mass="50053" checksum="5C53C2D7C3DCDF23" modified="2013-09-18" version="1">MREVISINVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKSQDPDQGFSTFFSETGQGKYVPRAIYCDLEPNVVDEVRTGAYRNLFHPEMMITGKEDASNNYARGHYTVGKELIDGVLDKIRRVADNCVGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQTATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGLERPNYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPVISAAKAAHEANSVQEMTMSCFEPNNQMVKCDPRHGKYMATCLLYRGDVVPNDAHAAVATLKTKRTIQFVDWCPTGFKLGICYQAPENVPNGDLAKVSRAVCMLSNTTAIAEAWSSLSLKFDLMHSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVATDSMGEEELEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQL9</accession>
    <name>S0DQL9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426821.1">
        <property type="nucleotide sequence ID" value="XM_023572755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQL9"/>
    <dbReference type="STRING" id="1279085.S0DQL9"/>
    <dbReference type="GeneID" id="35397491"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04010"/>
    <dbReference type="HOGENOM" id="CLU_030378_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="355"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT64740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="393" mass="42509" checksum="32AD4D3EEBE25511" modified="2013-09-18" version="1">MAEPLPAALKIPEVSRFINRANQLRSIKPAIAYWCEYHAVNQIVGKSLHTTDDDTFEFTKTLIERLEATKTERADDDAIVDNAAGQAYVEQFAQQTFERAERTMRANKVTRQTADTFDAAATFFDLTREWGEPDPEVVKKIKFAKWNAARILKAIREGKDPNETNPNAPEPEPEVALDPSDPEVQLLSGVPRASVEDAPDAGEPPSVPTFTDAPPRIPDDPGYFPPQPEHQPQAPEPFIPSPLSQSPTPGLSGGPPPPPPVGLPPAVSPVPEPPAQPATQIPPQPSPQIPTKLPSQFAPPPPEPFTPSAPPSWTTTPSAPHPAASNPPPVIRQAPAPQPPAPAPVQTTGFTTDQRDINQAQKHAKWAISALNFEDVPTAVQELRNALRMLGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQZ8</accession>
    <name>S0DQZ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_03873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426947.1">
        <property type="nucleotide sequence ID" value="XM_023572906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQZ8"/>
    <dbReference type="STRING" id="1279085.S0DQZ8"/>
    <dbReference type="GeneID" id="35397354"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03873"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT64866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="487" mass="54467" checksum="45A591E70043907E" modified="2013-09-18" version="1">MTSKPDSLPDKEIEEQRTVQDEIYIDPVAEKALLRKLDMWIVPPVMLLYLLSFLDRVNIGNARLYGMEEDLGLVGDQYQLAVSVLFVTYIASELPSNLVIKKFRPSRWIAFITTAWGIVATLTGIVQDFKGLVACRVILGALEGGLFPGLTIYLTMFYTKREYALRIGYLFVSAAIAGSLGGLLAYGIGHMDGVAGLKGWRWIIIIEGIPTFVLGIAVWFWLADDPDSAHYLTINERELIDARMRRQIGHTKSSDQMHKADVYAGLKDWKIWLFCIGQFGGDTILYGYSTFLPTIIRGLGDWNTAQVQALTIPCYAMGAITYLVVAWFSDRTQRRAVFTVILGLVCAIGYALLVSPAPSGVRYFGCFLAAMGLYVIVGLPLAWLPSNNPRYGKRTVATGLQLTIGNSAGIPAPFLYKTHEGPRFVKGHAVSMALVAMSSLIYMAFWAWFRRQNKRKVEGKEDHRTQGLTEEEAEELGEHNPRFHYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRC8</accession>
    <name>S0DRC8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_03724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427086.1">
        <property type="nucleotide sequence ID" value="XM_023573071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRC8"/>
    <dbReference type="STRING" id="1279085.S0DRC8"/>
    <dbReference type="GeneID" id="35397205"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03724"/>
    <dbReference type="HOGENOM" id="CLU_001859_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT65005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="491" mass="56445" checksum="9F5AE5FC02469678" modified="2013-09-18" version="1">MGSQQFDESIRGALPRDFTWGFATAAAQVEGAWDKDGKGVSIWDTFAHTPGKVKDGSTGDDAVKSYDLYKTDVEWLRKYKVTGYRFSLSWSRIIPLGGKDDPVNEEGISYYNRLIDELLANNITPFVTLFHWDIPQALEDRYGGMLNKDAYTTDFVRYARVCFEHFGDRVKNWITYNEPGVYSLAGYAAGVHAPARSSFRDRNEEGDSSTEPFIVSHTELVSHAYVADMYKREFKPKQKGTIMITLHGNWSEPWDVDDPLDQEAAERAREFEIAWFGDPLYKTGDYPESMRAQLGDRLPRFTPEESKLVLGSSEFYGMNSYSAFYVRHRDGPADITDHLGNVEKLDENKKGEWRGPMSDTYWLRTTPWGWAKLLRWIWNRYGIPIYITENGTTAQGEHDWKPNGPDDVLEDPFRVDFYKSYLTEVAKASQEGVVIKSYFGWTFTDNWEWAAGFSDRFGATWIDFGSEHKTRYAKRSGYFLGAFFNHLISTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRD0</accession>
    <name>S0DRD0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426048.1">
        <property type="nucleotide sequence ID" value="XM_023571805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRD0"/>
    <dbReference type="STRING" id="1279085.S0DRD0"/>
    <dbReference type="GeneID" id="35398339"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04858"/>
    <dbReference type="HOGENOM" id="CLU_006320_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="38"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="650"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="724"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT63967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="775" mass="86556" checksum="21B638F043C34E93" modified="2013-09-18" version="1">MESIARISSLMETARELTLDAAQATRGARTSSRPLDRNQMRKLLDSRNDREVLEGLRRVMAMMYRNHKTLPFFSSVVKNVASPNIEIKKLVYIYLIHHAEQEPDLALLSINTIQKSLSDQNPQVRALALKTMSGIRVPVISQIVSLAIKKGVADMSPYVRKAAALAIPKCHRLDPSQAPQLIDYLSTLLGDKQYYVAGAAVSAFLEICPDRIDLIHKHYRTLIKQVVDMDEWSQLATLRLMMYYARKCFPRRTESPDESTENSQDQRVDDFYGESRQGSRSHGSSVLDPDLELLLNGIRPLLQSRNAGVVVAVTRCYVDIGTPEYVKQAIGPLIALLRGAQDIQETALFNIVSVCLLRPTDFVKYASHFLVRATDTAPVWELKLEILTIIFPHSPPHVKSLILKELEHFSQGTNKALVREAVRAIGRCAQTDTSAAPRCLKLLLGQITSLDGTLAAESLTVIRHLIQQDVQGHVGTVVRLAKNLDSATDPQARATIIWLVGEFSGLNGEDNIAPDVLRILLKEFSNESPVAKQQILLLGAKVYLHHLNRRTEAEKERDAEEDPPMHTDTHPIVRLWEYVLLLVRYDTSFDLRDRARMYRSLLAVPQLATLMLLAEKPAPHAPSPSESRKGFLLGSSTLVLAGGGGIHGLRGYEPLPDWVEEGKQPDRRLREPEGSQSSRYDVERSTLPASERLDEAAKTVMPSRSNGTGTGTGEAVGAKTLDDWLAEEEQESEETEEETEEESSEEEEDDEEEDDEEEEETDSDDDGEADRLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRD4</accession>
    <name>S0DRD4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427091.1">
        <property type="nucleotide sequence ID" value="XM_023573077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRD4"/>
    <dbReference type="STRING" id="1279085.S0DRD4"/>
    <dbReference type="GeneID" id="35397200"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03719"/>
    <dbReference type="HOGENOM" id="CLU_1768210_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051196">
        <property type="entry name" value="RSAD2/Viperin_antiviral"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="147" mass="17100" checksum="11390F2B3FFC55B7" modified="2013-09-18" version="1">MASSSSRPTVVNIHNWNEDMSAEIERLAPFRWKVFQCLLVAGENEDVTRLRDARTFLVTDRQWKTFCDRHKHLPCYVPEDTNAMASSYLLLDEYMCFLDKGEGMLTRSESILKVGVKKAMGQVVWDRGSFLERGGIYDWGRSEKLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS25</accession>
    <name>S0DS25_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to isotrichodermin C-15 hydroxylase (Cytochrome P-450 monooxygenase CYP65A1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_02170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427321.1">
        <property type="nucleotide sequence ID" value="XM_023573869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS25"/>
    <dbReference type="STRING" id="1279085.S0DS25"/>
    <dbReference type="GeneID" id="35395652"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02170"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT65240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="484" mass="55611" checksum="7A0F0E1C8F5226BC" modified="2013-09-18" version="1">MALLSNLQLDSHLRYHGVLETGLIVILILTVTLVLKALYNIYLHPLSKYPGPRLAAATRLWYCYHCIQGNLVHALHEAHQKYGDVVRTAPNELSYTDPKAWNDIYGHRGGKGEMVKDPTFYSNISSGPGSIINAEQFRHRILRKQASHGFSERALRSQEDVIKKYADLMLERLEECAASENPTVDIVDWYNFFTFDVMGDLVFGQSFDCLTNWGYHPWPFLAPLSKWLVPPDIRRRRADQRKLAVEKAEYRKSIDDGRQDLISGYLLPDSGITALEYQSTVETLIIAGSETTATLMSGVTYYLLRDPERMAKVKSEIRGAFSTAEQINLVNVNRLPYLLACLDEALRVHPPVPDTFPRNTGPDKQIICGKVVPPHTTVGVHQWSTYHSSRNFRNPDDFIPERWLQGNNTKYEGDRKDALQPFHVGPRNCLGRNLAYFEMRLLMARLLWRFDLELDPRSADWNRQEAYLLWEKPPMFVKLVPRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSF2</accession>
    <name>S0DSF2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to sorbitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_04469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426403.1">
        <property type="nucleotide sequence ID" value="XM_023572242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSF2"/>
    <dbReference type="STRING" id="1279085.S0DSF2"/>
    <dbReference type="GeneID" id="35397950"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04469"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF7">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="31"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT64322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="428" mass="45073" checksum="FD0473EECFE41DCE" modified="2013-09-18" version="1">MAPVATGEIVPTHLPAGPSKPLSIGASVLHGPRDLRLETRTIEAPAAGELQIAIKATGICGSDVSYYKKFANGDLCACHPLSLGHESSGEVVAIGPQVSGFKLGDRVALEVGVACGNCGICRKGRYNLCKKLRFRSSAKTYPHYQGTLQERINHPAVWCHKLPDNVSFEAAALLEPLSVAIHAVNRARPEPGSTALVIGAGTVGLLTAAMARQSGCTSVTITDIDAGRVNYAISRGFATHGFVTPLSRLNSSNYSSGISTPETGIITPASTFSTASRFDGAKSLAADILASSNPAGAFMLEEDEDGVDVTFECTGKEICMHTSLYATKAGGKVIMVGMGTPIQTLPLSVAHLREIDILGVFRYSNTYPTGIRLLCSQAANPSGCSLPSLDDMVTHRFKGLDQAQRAFELATRTSDDEGKLVLKIVIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT05</accession>
    <name>S0DT05_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to GNT1 alphaN-acetylglucosamine transferase K. lactis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427647.1">
        <property type="nucleotide sequence ID" value="XM_023574263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DT05"/>
    <dbReference type="STRING" id="1279085.S0DT05"/>
    <dbReference type="GeneID" id="35396003"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02521"/>
    <dbReference type="HOGENOM" id="CLU_034860_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT65566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="348" mass="40504" checksum="DB42ED5514C8CA2B" modified="2013-09-18" version="1">MTPPFPPSFMASRRYRWAAGLTLAFFVFFILSNNGFLSQKPLEKFHGSIEVDWSRFAYTQYVTNSDYLCNSVMFFESLNRLSSRADRVMMYPSHMFEANNGSSVDTQLLIKARDEYRVKLVPITVQHKDNKDDTWADSYTKLLAFNQTQYSRVLSIDSDSTLLQEMDELFLSPPAPVAMPRAYWLFPEKEILSSQVILIQPSEKEFARIMAKVDSASENDFDMEIVNYLYRESALVLPHRPYDLLTGEFRADNHKRYLGSDTEPWDPAAVYNEAKLVHFSDWPLHKPWIQSDEELRLQSQPNCTTLADGAEDCSARIIWNSFYTDFKRKRKEICGLDEVILSKEEYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTE6</accession>
    <name>S0DTE6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427930.1">
        <property type="nucleotide sequence ID" value="XM_023574605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTE6"/>
    <dbReference type="GeneID" id="35396310"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02828"/>
    <dbReference type="HOGENOM" id="CLU_193160_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484905" evidence="2">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="84" mass="9473" checksum="DB251A9FCF0864A2" modified="2013-09-18" version="1">MRFSIFTLVALVSASSASLVRRVDVNVPAMTNADGVVVPFDTAGVVQPAKKRDLEQKKRDLAQRKRHISRKRRAVSQEKQQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU72</accession>
    <name>S0DU72_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable Ca2+-transport (H+/Ca2+ exchange) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_04731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426169.1">
        <property type="nucleotide sequence ID" value="XM_023571947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU72"/>
    <dbReference type="STRING" id="1279085.S0DU72"/>
    <dbReference type="GeneID" id="35398212"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04731"/>
    <dbReference type="HOGENOM" id="CLU_008721_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="254"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="489"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT64088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="641" mass="70630" checksum="E17C787BDF9D1D11" modified="2013-09-18" version="1">MSSCKVPFQFLHFFFVPIVSIIGFSTTCPRTPATICYPALLFYLLYWLLTHTTTTVNHFNIKRQAHTLSRSSTDQSWNPFRHVEWKRQARALSDAGRLEQQTTQEETAGQTLAHAVTEPGRSGPAREWSTEETMTDMRRSKEGDYDREKTIGGSPIDGNDDIPVSQRSLVSDENQLRNRKREDIPAAADNNIDLEKRKLKKRESTKIFRRVEPKEPFTVRNQLQRTFLNSYINILLIAAPVGIALNYIHSVNRIAVFVVNFIAIIPLAAILSFATEEIALRTGEVLGGLINATFGNAVELIVAILALVDGKVIIVQTSLVGSILSNLLLVLGFCFFFGGLRRESQYFNETVAQTAASMLALAVASVIVPTVFDQAKDTPPANVARLSRGTAVILLIVYAAYLLFQLKTHQSTFAKESQKVAAKPWSRGSAGAGDIRQGIMVPGALVGGGMTGREENERLSEMLMNPHRLPKAEDDEDEEEEPQLHFWVAIATLTIATVLIALCAEFMVDSIDAVTKTGGVSEEFVGLILLPIVGNAAEHATAVTVAIKDKMDLAIGVAVGSSMQVALFLIPLLVIIGWGMGNDAMNLSFDLFQVATMFVAVLLVNYLIADGKSHWLEGWLLICLYSIIAVCSWWYPTHSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUT0</accession>
    <name>S0DUT0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable GPI-anchor transamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_04500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426374.1">
        <property type="nucleotide sequence ID" value="XM_023572207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUT0"/>
    <dbReference type="STRING" id="1279085.S0DUT0"/>
    <dbReference type="GeneID" id="35397981"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04500"/>
    <dbReference type="HOGENOM" id="CLU_044656_2_2_1"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028274779" evidence="7">
        <location>
            <begin position="24"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT64293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="391" mass="43845" checksum="09E8F54182A2B5A5" modified="2013-09-18" version="1">MNLSILRFHAIVAAAMFTTIAFGEHTSNWAVLVCTSRFWFNYRHLANVLSMYRTVKRLGIPDSQIILMLPDDMACNPRNAFPGTVYSNSDRAVDLYGDNIEVDYRGYEVTVENFIRLLTDRVGAEMPRSKRLLTDDRSNILVYMTGHGGNEFLKFQDAEEIGAFDLANAFEEMWEKKRYHEILFMIDTCQANTMYSRLYSPNIIATGSSKLDQSSYSHHADNDVGVAVIDRYTYYNLEFLENNVKDLNSQKTVGELFDSYDFGKIHSHAGVRYDLFPGGEENARSRLITDFFGNIQNVEVDRSGNLTLEEDLLALSKKIALLQQKEAEAAKESVGEKVSAKAPASAPTEAARKIQKAKALTDGNWWTKKVVGATALAGCGLLWGLGSFLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUZ8</accession>
    <name>S0DUZ8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427298.1">
        <property type="nucleotide sequence ID" value="XM_023573843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUZ8"/>
    <dbReference type="GeneID" id="35395628"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02146"/>
    <dbReference type="HOGENOM" id="CLU_023457_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF23">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="702" mass="78345" checksum="DF0B8607E0356B66" modified="2013-09-18" version="1">MSPSKRHRPRVPLDKRKRAVRACLSCRESKKKCVMISGYQCQECTRYGLRCTFEPILEDPGNHLCDVVSEPHGSTVWDKLAIDVSRRLREEYPDIKLNSEQFSIVSNLFSEAVQERGPILFPQSDSSIEQSSTALGQVPQPRVVSGFEVSDLPVRGVKDHAPSASHASFLAAVSETIPPVCSTDEDDRSYTSSLAQEDDAFLINNIIDQIPPREVSEALVTLFFTFLESNWYYFDEKRFWGLLTHLYADRASAQQLHPTDVCQVLLVLALASTFKHLAEPFEFANGERDVPGSKLFANATRLLSRVIAANSVESVTCFLLMSLYLLATDDIEHHHIYLGLALNQAVGLSMHRAGVKAEETPEAREVKGRIFWTVYTVERLTSGVMGLPTMLQVKDISVSLPQKRKDLDGDSDQAVDRLIAIIKLTMGMDEIINEGPIEKRASTYEWALFKMESLRTPASMGVSKTLASSFRADAHLQIIYQMIWVSLGRSATLRTVRQSLQPTSVLMSPGDQEAHLRSQNLVEHCREAATTIIDWISQLHHRGLLAKYSFTDFHTCSSATIMLLLYSILDPNHDSLPITQGINALHFMAEGSRLAMNALRLIRRLQETIQKSIGVNISGSAISQASLSQMASSQDLSETQTIDGCRNISYDSTGNYESHVLPNSPSLFPDLEPWLLEYSDPYSMMFGFDGSCSAFNTDTPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV22</accession>
    <name>S0DV22_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427323.1">
        <property type="nucleotide sequence ID" value="XM_023573871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV22"/>
    <dbReference type="STRING" id="1279085.S0DV22"/>
    <dbReference type="GeneID" id="35395654"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02172"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="271" mass="28686" checksum="60F423465025F278" modified="2013-09-18" version="1">MNILNGNALVTGAGSGIGRQLSLAYVRAGIQGITLADLNKDALSETARLIQAQYPDVKVLPIVVDVTDEKSVNAMVDQAVQTFGTLDCAANAAGVIVKSREKSAHVPSSEFDRVMNINTRAVALCMQAEARAMLKQPRKLTSAYWQDERRAQVGSIVNFASVCGLQAMLNVMPYVASKHAVMGMTRSAAAEHGPEGLRINAVCPGIVDTPFIGDLKALKGGNEQDPAFANPLGRLCYPDEIADAVVFLSSTMSSYVNGIGLVSDGGRSVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVQ3</accession>
    <name>S0DVQ3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428720.1">
        <property type="nucleotide sequence ID" value="XM_023575555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVQ3"/>
    <dbReference type="STRING" id="1279085.S0DVQ3"/>
    <dbReference type="GeneID" id="35397162"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03681"/>
    <dbReference type="HOGENOM" id="CLU_973814_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="288" mass="32820" checksum="BB7FC33BD03089A3" modified="2013-09-18" version="1">MSLRPYLEAAYREVRLSTEVALNPLQKLDCHLKKGQDNLILVYGGSFNPPHRGHLDVLLSALHPAVNAAAVVVLPSEDFHLRHKLANSHPEFFMSRKTRAALWAEMPQVPRNKVWIWSETWYPFYTFMGAAQRLCEEDGYKIVFSHLIGPDNLNRADALNNLPYRLPRILVTNKARHVPSQFLPNGQPTKWKGFGEWLPQKMAYNDQNGKLEETAEEATLWTCRGTDSLAQPTMGYYLDFAKRPTGSDINSTAMRRDLLERHSLDEEILAQLSTVDLLSILEPVLRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVS2</accession>
    <name>S0DVS2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">ITPase</shortName>
            <shortName evidence="13">Inosine triphosphatase</shortName>
            <ecNumber evidence="13">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_02450</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 14">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="13"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428740.1">
        <property type="nucleotide sequence ID" value="XM_023574181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVS2"/>
    <dbReference type="STRING" id="1279085.S0DVS2"/>
    <dbReference type="GeneID" id="35395932"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02450"/>
    <dbReference type="HOGENOM" id="CLU_082080_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="168"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT66659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="184" mass="20234" checksum="9E476294F9FB98FA" modified="2013-09-18" version="1">MAAHKVNFITGNANKLREVKAILEPEIEVLSKSIDLEEVQGTLEEVTESKCRRAADLVKGPVLVEDTALCYNALSGLPGAYIKWFMTSIGHQGLNNLLAAYTDKSAEAVCTFGYCAGPGEKVILFQGRCPGKIVPPRGPPDFGWDAVFEYEGQTFAEMDKAEKNKISHRGRALAKLQAWFKDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVT3</accession>
    <name>S0DVT3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to M.leprae yfcA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428750.1">
        <property type="nucleotide sequence ID" value="XM_023574755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVT3"/>
    <dbReference type="STRING" id="1279085.S0DVT3"/>
    <dbReference type="GeneID" id="35396445"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02963"/>
    <dbReference type="HOGENOM" id="CLU_062974_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="2">
        <location>
            <begin position="119"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="297" mass="32753" checksum="103A15F40BA6E47D" modified="2013-09-18" version="1">MATRKCLSPLIKAPKSIASSICHQCQRSFVTTPAQLAGHNKWSKTKHIKAVTDKKKMTERSNFTKTIAMYSRMYGDDVKFNPQLATAINAATKASIPKNLIEGAIARGQGRSATGAQLESMSLEVLMPPDIAMVIDAETDNKTRTLHDLRLVVKKAGGVVGSTTFYFTRRGRAIFKAKECGPSLSDVLDEAIELEGLEDVEELPEGDFLAWTQPNTLTAITEALSKKFELEILDADIVWAPNEDTTVSIDTTDQADALDMLFNGLREYPEVRAIYANVRQGAVGDEEWDKVERNLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWB3</accession>
    <name>S0DWB3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Modifier of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NCT transcriptional regulatory complex subunit mot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FFUJ_03118</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity. Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms the NCT transcriptional regulatory complex with nctA and nctB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428841.1">
        <property type="nucleotide sequence ID" value="XM_023574930.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DWB3"/>
    <dbReference type="GeneID" id="35396600"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03118"/>
    <dbReference type="HOGENOM" id="CLU_000315_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045898">
        <property type="term" value="P:regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000445">
        <property type="entry name" value="Related to MOT1-transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="1318"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1663"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="181"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="687"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCT66760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1895" mass="210976" checksum="ECD12C18D6F0C0BD" modified="2013-09-18" version="1">MASRLDRLVTILETGSTRLIRDTAVNQLADWQKQHPDELFNLLSRVVPYLRHKEWETRRTAASAIGKIVEHAPIYDPNSEDAPEEGKKEEPVPENGHVKKEEEDDVKKLPSDDGFFKLESLNVEMILKYGKELLRGGGIEYGLAALDPQARLTHQKKTLNGRLGLLGRKYEDDEIAYTGGDNITAPMTPMDTTNGNGHARPDGSGAQSQVPEESQLSSRQLNVLKRKRKREAMKASQGKGGFGDLSVRRSMTSGSDNLGDDTAMPDGDTKKNSKVNDYFNLDRPADVDEDTKVVSEFKGPVIPIKSELEAEETMEGAEWPYDRLCDFLKVDLFDPSWETRHGAAMGLREVIRVHGGGAGKLRNKTRKENDVLNQKWLDDMACRLCCVLMLDRFTDYSSDTSVAPIRETIGQSLGSVLKHLPSSSVYSTFQILYRMVMQEDLKLDRPVWSVCHGGMIGLRYVVAVRKDLLLQDSDMIDGIIKTVMKGLGDMDDDVRSVSAATLIPMAKEFVTLRPTQLEGLVNIIWESLSNLGDDLSASTGRIMDLLATLCGFPEVLEAMKASAAQDEERSFTLLVPRLYPFLRHTITSVRVAVLKALLTFAKLDAETSQGWLNGRILRLIFQNILVERDRDALNMSLDLWTSLVESLASKPAVLADEFTAHIDSMMQLTLHPIGVSRNPIPMNASLFQKPSGGTYTMPGVTQHTPRKPSSPDGSDRAPKRRRKSTKIDDTPTASLTHDVDGHMMQGDVDLVGMDVLIRSRVSAAKAMGFIMSRVPVASLDDYDALLIPGLGSAFSSSQMTACVIIDEFAMNSQQLGDSPRYLENLQRIIDSERPAAYRDLVNYIQRVRTQCQQLIHLFRDHGKVSHSKLPTLPVVVQGEAEAGPSAFSIATAEKCIGDDYEKLKKAMPPGQRLIASQQLSDARDMTILAIEEAKTVKAARDVRVKAAAACAMVGMRVLPKKPSPLIKGIMDSVKTEENQQLQIRSADTIARLVQLFTEKGRKGPADKVVSNLVKFSCVEVAETPEFPVHASKTDCVLSMQKEEDRVDHPDAAKWAREAKAARITRRGAKEALEILSRTYGASLLETVPSLRTFMEDPLVRAFSPDTLPGEAKDPEQTFGQEIVDAMSVIRTMTPTLDKALQPFIMQMMPLVIKALHSELSVFRYMAAKCMATICSVMTVDGMTALVEKVLPSINNPVDLNFRQGAIEAIYHLIAVMGDAILPYVIFLIVPVLGRMSDSDNEIRLIATTSFATLVKLVPLEAGIPDPPGLSEELLKGRDRERTFIAQLLDPKKVEQFQIPVAIKAELRSYQQEGVNWLNFLNKYHLHGILCDDMGLGKTLQTLCIVASDHHQRAEEFAKTQAPDVRKLPSLIVCPPTLSGHWQQEIKTYAPFLSVTAYVGPPAERKAMKARLGETDIVVTSYDVCRNDAEVLDKHSWNYVVLDEGHLIKNPKAKITQAVKRLASNHRLILTGTPIQNNVLELWSLFDFLMPGFLGAEKVFLDRFAKPIAASRFSKASSKEQEAGALAIEALHKQVLPFLLRRLKEEVLNDLPPKILQNYYCDLSDLQQKLFEDFTKKQGKKIQAEAGREDKEAKQHIFQALQYMRKLCNSPAMVMKPGSTLYDETQKILAKQGTSIEDAQHAPKLTALRDLLVDCGIGVEGNDSNDPLYQPIKPHRALIFCQMKEMLDMVQNKVLKELLPSVSHLRLDGSVEANKRQDIVNKFNSDPSYDVLLLTTSVGGLGLNLTGADTVIFVEHDWNPQKDLQAMDRAHRIGQKKVVNVYRLITRGTLEEKILNLQRFKIDVASTVVNQQNAGLSTMDTDQILDLFNVGDAAPNLLADKEKNNIEGREEDMVDIETGDVRVPGKKAWLDDLGDLWDNKQYEESFDLDDFMKTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWH1</accession>
    <name>S0DWH1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to FMN-dependent 2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428985.1">
        <property type="nucleotide sequence ID" value="XM_023575714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWH1"/>
    <dbReference type="STRING" id="1279085.S0DWH1"/>
    <dbReference type="GeneID" id="35406528"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13072"/>
    <dbReference type="HOGENOM" id="CLU_038732_2_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="350" mass="37016" checksum="8538819BE314C207" modified="2013-09-18" version="1">MAPPGPITTPLTSLLGIKHPIILAGMARVSGGRLAAAVSNAGGLGIIGGFQYTPDQLREIIVEMKANFSRPDLPFGVDLALPQIGGNARKTNHDYTGGKLDELVDIIIDSGAKLFVSAVGVPPPQVIKRFHDKGILVMNMVGHPKHATKALELGVDMVCAQGGEGGGHTGDVANSILIPAVADVASKYHPPLLKGLPALVVAAGGISSGRSLASSLMQGAVAVWVGTRFVASVEASCSEEHKKEVVSCGFEDTQRTLVISGRPLRMKTNDYIRKWHEQPDKIKELCDKGVVPIEYDFEQGNDFDLPHLMGQVAGAITKIQPAGEIVDEMVKEAVDMLKLGGTYLTAIPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWJ8</accession>
    <name>S0DWJ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428957.1">
        <property type="nucleotide sequence ID" value="XM_023575683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWJ8"/>
    <dbReference type="GeneID" id="35406500"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13044"/>
    <dbReference type="HOGENOM" id="CLU_1686736_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="156" mass="17502" checksum="FB379D062CBA3646" modified="2013-09-18" version="1">MTSQPATPSAIAVSREDVNGDTVNHLRQRLHEAEHTITGLKATQDFVVAQNAELKKENNQLRENMAVLRCQNSRAGNSSNEAIPVGSVTMSPDDLKKLQGILQEVKRHGSELHQKAGELRDSVLLKQEDFSRKRRRTDSDTDRNEEENPAMQFVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWQ5</accession>
    <name>S0DWQ5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_03813</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427004.1">
        <property type="nucleotide sequence ID" value="XM_023572972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWQ5"/>
    <dbReference type="STRING" id="1279085.S0DWQ5"/>
    <dbReference type="GeneID" id="35397294"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03813"/>
    <dbReference type="HOGENOM" id="CLU_013691_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="713"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT64923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="751" mass="85356" checksum="B3973BE193AD5EC1" modified="2013-09-18" version="1">MGEAIPPEDVTYGIKGLPRPPNAMRYPGEIPYVKGLPWTLFVLALERFKSMPVNDKLSYFQIAGIHGYPEVACDGAPEPKHAPDKRTKQAGDQPFGGYCNHNSLNFPAWHRPYMLLFEQRIWENMRLIINNWTSEHGLPTSEANEWYTAAKHWRMPYWDWARQQMYHEDLVCPLVLTQGAVRIYPPTTIKNRFPRSGLYPNPLVGFENPEKDPKTGKPLPFGSMPEGNAKWNIHDNPIVHDELPLKKDCDWAPWSKASATSRYGIFKGEEDEKDPARYFRGLEGVNHCWRSNASLARVHEDGPDGKPRWSTMEQHSKDYTWNPGSLSDAVNRMFSKGYNSNWGQFASTKWIAEGKGCPQTGYISLEYIHNNIHNLTGGSDYATGMGHMSDVPVAAFDPIFWLHHVQIDRLLAIWQCLNPKLWFDNEPLGELNTAGMKASIVADDKETDPLEPFHRKNNDPEKEVWTAQACRDWTELNYQYDDLAEVTERTMRKHGRFIPGEFQAELQSHIDTIYPGTGHLIESINRSSAIPIGRRLCQSQPGPWKDYIINVVYDRYALDGLSYTIQFFIGGPPGEDTTIFEKHNYIGHVYSFGGRQSTSEGSCRNCKKQAAAQVLSCAQVPLTIHLLQHVKDNIPDHSLKDFGEIEEYLRLHLRWRLVRYGGEVISEEGFKRNFSKVQISVLRGTGRIKPDNALSAGSVSSLYSDYVPLPEITDGKPGGLQRDKASENTKPFVPQTKSAVRPLPTRFPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXE9</accession>
    <name>S0DXE9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428128.1">
        <property type="nucleotide sequence ID" value="XM_023574844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXE9"/>
    <dbReference type="GeneID" id="35396524"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03042"/>
    <dbReference type="HOGENOM" id="CLU_045142_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="338" mass="38466" checksum="A0EEB6935057787D" modified="2013-09-18" version="1">MSSVNPFTPVTPPPESHSFPKLPAQRPLQNNLKRKASMQEPFSGLTGLNTPTMMAPPPPPTSQPRMSSSPNRNSGPSSSSTPQSSESTTPELPSIAGANLDPKYLAMVSRIAAYYQQRCQAVANYQQQRCQAWANMHRQKCQDMMQASMLVVAWYVRDRIQRRRRREKRHFRSGLRRRTDQNKIARTEVVRRWVKQIPEGPESPNEPLNVQLADREEAEFSMDRETQPDKDTKLFEMADNLIKSQYKKIEVPIMGVLNFDESDNDSESDLDEPEPEQYDEMDEAEDLAEDDEYYEVEDDELYDDEDEIEYTGDGASEVVHHGTGTGSGSRNNNLSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXT1</accession>
    <name>S0DXT1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA ligase</fullName>
            <ecNumber evidence="7">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_13553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="7"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429427.1">
        <property type="nucleotide sequence ID" value="XM_023576252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXT1"/>
    <dbReference type="STRING" id="1279085.S0DXT1"/>
    <dbReference type="GeneID" id="35407007"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13553"/>
    <dbReference type="HOGENOM" id="CLU_005138_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000018">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="10">
        <location>
            <begin position="544"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="635"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="858"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT67346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="880" mass="97899" checksum="3A12E8EB0DCA71D9" modified="2013-09-18" version="1">MPSPTKKRKLNNGTKSSTPARGLEYFFSKQKQNDTESSKNSRTEENAEGISSDAATELTDEELARKLQAEWDQEVANTPQNTLQAQALQLPSKHIESVSRDESPSPAGPKPKPPVTLPTSLNKPGILTSTKPTLSLQAAGMAEDTTTTSIALDETPLTFDPSEYLDQLKEHWASEGGNASYALLTRCFILINGTTSRIKIVDTLVNCLRVLIEGDPTSLLPAVWLATNAISPPYISMELGLGGSAISKALRNVCGLDNRALKAIYDKYGDAGDVAFEAKKKQSFTLRKPKPLTIKGVYETLVKIASSQGQGSSETKQRLVDRLLQDARGGEESRFIVRTLSQHLRIGAVKTTMLIALSRAFLLSRPPGADFPLKSVSDLAKLKKEDLAEIWGRAEEIVKACFARRPNYNDLVPVLLEIGISEELLIRCGLTMHIPLRPMLGSITRDLSEMLTKLQGRDFACEFKYDGQRAQIHCDEGGKVSIFSRHLEVMTDKYPDLVELIPKIRGEGVDSFIMEGEVVAVDRETGELKNFQTLTNRARKDVEIGSITVDVCMFAFDLMYLNGQPLLDRPFRERRELLRSLFTEIPHHFTWVQSLDATSADSESVLEFFKAATDIKCEGIMVKILDNLPTVPCTEEADGDGLDGTNKLLTPKSKSKGKAKSRGKKDENGETKAKTRRKPLLATYEPDKRLDSWLKVKKDYNASFDTLDLIPVAGWHGQGRKAKWWSPILMACRNEETGSLEAVCKCMSGFTDAFYKANRQFYDDGEESGELKNTRTKQPAFVEYSGPRPDIWFEPQEVWEMAFADITLSPTYTAAIGLVSDERGLSLRFPRFMKKREDKSLEEASTNDFLAGLWRKQEAKAETTKSETGVEAEEAEEVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY59</accession>
    <name>S0DY59_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_13598</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429471.1">
        <property type="nucleotide sequence ID" value="XM_023576301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY59"/>
    <dbReference type="STRING" id="1279085.S0DY59"/>
    <dbReference type="GeneID" id="35407052"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13598"/>
    <dbReference type="HOGENOM" id="CLU_008776_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014402">
        <property type="entry name" value="Sig_transdc_resp-reg_Skn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF361">
        <property type="entry name" value="TRANSCRIPTION FACTOR SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002595">
        <property type="entry name" value="RR_SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="347"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT67390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="586" mass="64598" checksum="208C244A074693DE" modified="2013-09-18" version="1">MSGDGTSTPGVGGSNASEFVRKLYRMLEDPAHQDVARWGKDGDTFVVVENEKFTRSILPKHFKHSNMASFVRQLNKYDFHKVRQTNDSGSAANGANTLEFKHPNFRVGSKDDLDNIRRKAPAPRRTQATEDFTTSHHISVMTEQLTATQQQVQQLQELFTEVSQTNRLLVNEVLTLQKMLNAQKQSQHEMLNFLSPSGNRHQQGMHLNVGTSPLDGSDDSAPELRRARELLSSVTPDQIADRELERLQGVYGSPADSAVVIPQASMPMMHDPMNDINRYPVYPVGQTVGIDPFHSDHIHKIPYAMPNESSANAMQEVPAPQPINIQTHANSNSSTNSALTWASRKPRIFLVEDDPTCAKIGIKFLKSMGCEVEHAQNGADAYSRITSVARDHFDMIFMDIIMPKLDGVSTTMYIRQDCPAIPIVAMTSNIRSDEVHCYFEHGMNGVLAKPFTKSGMQKIVENHLSYLLKGYDPSTQQESGSGYVVGGAGYMNPPSNLNTPGGTNFKFETTPTPPATGATWSPGQMPQQSPMTAGMDQGYGMVNGASQYGLTPTSASRASFPTNISQTSQGRMDGQSPPEKRQRTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYD4</accession>
    <name>S0DYD4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429617.1">
        <property type="nucleotide sequence ID" value="XM_023576219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYD4"/>
    <dbReference type="STRING" id="1279085.S0DYD4"/>
    <dbReference type="GeneID" id="35406978"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13524"/>
    <dbReference type="HOGENOM" id="CLU_033361_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="391" mass="44023" checksum="8FDB6A120C067FB3" modified="2013-09-18" version="1">MSHRKYEAPRHGSLAYLPRKRAARHRGKVKSFPKDDPKKPVHLTAAMGYKAGMTTIVRDLDRPGAKANKKEVVEAVTIVDTPPMIVVGLVGYIETPRGLRSLTTVWAEHLGDELKRRFYKNWYKSKKKAFTKYAKKHSENSGASITRELERIKKYCTVVRVLAHTQIRKTPLKQKKAHLMEIQVNGGSIADKVSFGQELFEKPVDISSIFEQDEMIDVIAVTKGHGFEGVTARWGTKKLPRKTHKGLRKVACIGAWHPSHVQWTVARAGQRGYHHRTSVNHKIYRIGKGDADDNAATEIDVTKKTITPLGGFVRYGEVNNDFVMVKGSIPGTKKRVMTLRKTMFPQTSRKALEKVSLKWIDTSSEFGHGAFQTPAEKKQYQGTLKKDLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZU1</accession>
    <name>S0DZU1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429008.1">
        <property type="nucleotide sequence ID" value="XM_023575742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZU1"/>
    <dbReference type="STRING" id="1279085.S0DZU1"/>
    <dbReference type="GeneID" id="35406553"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13097"/>
    <dbReference type="HOGENOM" id="CLU_070871_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="223" mass="24357" checksum="98193FC2B76D9F83" modified="2013-09-18" version="1">MSDITPLVLEKIPQTDTCLSALELARDALPIPILNHSLRVYLLARYIAEKEDSPFKSGDQSPLLFVAAIHHDIGASHLYSGEHRFEICSADCAKAHLVKSGYSEAASHQVWTAIAVHTSPGIAERIDPLSRLIRLGVLSDFGSKDYRTSLGVDEYYAEIETLLPRLDAEKCLGDAVVSQAKEIPHVDSLTWPNDAKFPAASWPGILLRAHAENPGHDGVNPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0T3</accession>
    <name>S0E0T3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_13472</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429353.1">
        <property type="nucleotide sequence ID" value="XM_023576161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0T3"/>
    <dbReference type="STRING" id="1279085.S0E0T3"/>
    <dbReference type="GeneID" id="35406926"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13472"/>
    <dbReference type="HOGENOM" id="CLU_000422_11_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000033">
        <property type="entry name" value="NUAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="249"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT67272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="742" mass="81383" checksum="96E3B8D1D7754FA0" modified="2013-09-18" version="1">MLRNTLARSAWRTSRRAVNVSRTFATTSQRPAEVELTIDGKKVSIEAGSALIQACEKAGSTVPRYCYHEKLMIAGNCRMCLVEVERAPKPVASCAWPVQPGMVVKTNSPLTHKAREGVMEFLLANHPLDCPVCDQGGECDLQDQSMRYGADRGRFHEIGGKRAVEDKNIGPLIKTSMNRCIHCTRCIRFSNDIAGAPEMGSTGRGNDIQIGTYLEKNLDSEMSGNVIDLCPVGALTSKPYAFRARPWELKHTESIDVLDGLGSNIRVDSRGLEVMRILPRLNDDVNEEWINDKTRFACDGLKTQRLTMPLVRREGRFEPADWEEALTEIGRAYQIKNPQGNEFKVIAGALTEVESLVVAKDMANKLGSENLALDTPTGSQPIAHGVDVRSNFLFNSQIWGIEEADAILIVGSNPRHEAAVLNARIRKQWLRSDLEIGVVGETWDSTFEFEHFGTDHAALKSALSGPFGETLKNAKRPMIILGSGVTDHADAKAYYETIGAFVDKHASNFRTEEWQGYNVLQREASRAGAFEVGFTTPSAEVAQTKPKFVWLLGADEVNEADIPKDAFVVYQGHHGDKGAQIADIVLPGAAYTEKAGTYINTEGRVQMTRAATSLPGASRTDWKILRAASEFLGAPLPYDDVAMVRDRMVEISPALAAYDVIEPVALPALSKVQLVDQNKGAQVTGTPLKKVIDNFYFTDVISRSSPTMARCSAAKATGDPRTNFMAPGMEEDKPMGQVEYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1N5</accession>
    <name>S0E1N5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to cell division protein CDC50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_07405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430685.1">
        <property type="nucleotide sequence ID" value="XM_023577653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1N5"/>
    <dbReference type="STRING" id="1279085.S0E1N5"/>
    <dbReference type="GeneID" id="35400882"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07405"/>
    <dbReference type="HOGENOM" id="CLU_025025_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT68605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="427" mass="47553" checksum="7F755E46E6F5E665" modified="2013-09-18" version="1">MADEQPRGIDHTDSIDSNDGPKQPDKKKSRRPANTAFRQQRLKAWQPILTPKTVLPLFFAIGIIFAPIGGALLYASAQVQEIRLDYTDCIEKAPTLGKDGGGFRGMPGSAVSTAFKSSNTSVNAQWAKESNVTVKLDNGVSVSNPRCHLKFTIPEEMGPPVLFYYHLTNFYQNHRRYVLSFDTDQLKGHKRSYNDIHNSDCTPLYGEGGKPYYPCGLIANSMFNDTFSSPVLSNPPKASSNDTWVYHMQNNTGISWDSDKDLYGNTAYNYTDILPPPNWHDRYPNGYTKDTPPPNLKEWEAFQVWMRTAGLPTFSKLYQRNNTQAMWSGTYDLVIDYRFPTLKYKGTKSVIISTRTVIGGRNPFLGIAYVVVGGVCIVLGTVFTVTHLIRPRKLGDHTYLSWNNAPGAKSGPSTAAASGRELRPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E233</accession>
    <name>S0E233_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-carboxymuconate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429798.1">
        <property type="nucleotide sequence ID" value="XM_023576677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E233"/>
    <dbReference type="STRING" id="1279085.S0E233"/>
    <dbReference type="GeneID" id="35408092"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14712"/>
    <dbReference type="HOGENOM" id="CLU_037887_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495471" description="3-carboxymuconate cyclase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="40833" checksum="669B7075F5A66404" modified="2013-09-18" version="1">MFSSGFFLPALLWLAQEATSHPACKPGMNSNAMTGKAIYVLTNEKANGVLAIPIGQDGTLSKGKVTMTGGAGSVAVDAEGKPATPDALISQSALTIAGNNIFAVNAGSNTLSMLRVSRSDPTKLQMVGKPVQVPGEFPNTVAASAKNGVVCVGSTGAKAGVSCSSFSRQGLGAMDELRTIDLGQTTPPAGPTNTLSQVLFSEDESMLFTMVKGDPAVNNTGFISVANVEMNNGVAAVSKQDARSSPEGTAVLFGSQVIPGTSKVFATDASFGAAILDVDPNNCEATTAAKGAVEGQTATCWVAISPATKSAFVTDVGRNRVVEMSLEDACVVSELDLTCNGDPGLIDLAASGNFLYALSPGNGTTQAAVTVLDVSGGSGSAKMVQHFELAGMASNTAMGMKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2T2</accession>
    <name>S0E2T2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_13165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429069.1">
        <property type="nucleotide sequence ID" value="XM_023575816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2T2"/>
    <dbReference type="STRING" id="1279085.S0E2T2"/>
    <dbReference type="GeneID" id="35406619"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13165"/>
    <dbReference type="HOGENOM" id="CLU_071379_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="203" mass="22840" checksum="78C0C6456ED2A723" modified="2013-09-18" version="1">MRRNFTSFNCRPSLCARAPPRINTSYPRVSSTQASRIDRITSKLPRRLQRYTSGLRNAPVSHIVSFLILHEITAIVPVLGLFGLFHYTNYVPVEYVTGHFGSYVEDGVGRFERYFTRKGWFGFGQNGEGEASNAATTHPDSKSEEAVERWHRGDGRYKVVVEVALAYAITKALLPVRIIGSVWATPWFAGILMRAKGIFTSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2U0</accession>
    <name>S0E2U0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_06713</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT67962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430042.1">
        <property type="nucleotide sequence ID" value="XM_023576882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2U0"/>
    <dbReference type="STRING" id="1279085.S0E2U0"/>
    <dbReference type="GeneID" id="35400190"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06713"/>
    <dbReference type="HOGENOM" id="CLU_026126_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="45"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="143" mass="15858" checksum="9EF7A54711F0C9EB" modified="2013-09-18" version="1">MSNSNENIHAQPMPAGLQTIDASEPAAPKAALHSRLTDLVNGAPVMLFMKGVPKCPSCLFGRRIVRILDHQAIHYSSFYVLKDETVRLGIKEYADWPTYPQLWVNGELVGGLDIVKEELSANPEFLSAHRVPEIEDYAARVMA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-10-25" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2U7</accession>
    <name>GA3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450 monooygenase 1</fullName>
            <shortName evidence="13">P450-1</shortName>
            <ecNumber evidence="4">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Gibberellin cluster GA14 synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">P450-1</name>
        <name type="ORF">FFUJ_14333</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Curr. Genet." volume="34" first="234" last="240">
            <title>Gibberellin biosynthesis in Gibberella fujikuroi: cloning and characterization of the copalyl diphosphate synthase gene.</title>
            <authorList>
                <person name="Tudzynski B."/>
                <person name="Kawaide H."/>
                <person name="Kamiya Y."/>
            </authorList>
            <dbReference type="PubMed" id="9745028"/>
            <dbReference type="DOI" id="10.1007/s002940050392"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Fungal Genet. Biol." volume="25" first="157" last="170">
            <title>Gibberellin biosynthetic pathway in Gibberella fujikuroi: evidence for a gene cluster.</title>
            <authorList>
                <person name="Tudzynski B."/>
                <person name="Holter K."/>
            </authorList>
            <dbReference type="PubMed" id="9917370"/>
            <dbReference type="DOI" id="10.1006/fgbi.1998.1095"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1999" name="Appl. Environ. Microbiol." volume="65" first="2558" last="2564">
            <title>Deletions in the gibberellin biosynthesis gene cluster of Gibberella fujikuroi by restriction enzyme-mediated integration and conventional transformation-mediated mutagenesis.</title>
            <authorList>
                <person name="Linnemannstoens P."/>
                <person name="Voss T."/>
                <person name="Hedden P."/>
                <person name="Gaskin P."/>
                <person name="Tudzynski B."/>
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    <reference key="5">
        <citation type="journal article" date="2000" name="Biosci. Biotechnol. Biochem." volume="64" first="660" last="664">
            <title>Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase.</title>
            <authorList>
                <person name="Toyomasu T."/>
                <person name="Kawaide H."/>
                <person name="Ishizaki A."/>
                <person name="Shinoda S."/>
                <person name="Otsuka M."/>
                <person name="Mitsuhashi W."/>
                <person name="Sassa T."/>
            </authorList>
            <dbReference type="PubMed" id="10803977"/>
            <dbReference type="DOI" id="10.1271/bbb.64.660"/>
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        <scope>FUNCTION</scope>
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    <reference key="6">
        <citation type="journal article" date="2001" name="Appl. Environ. Microbiol." volume="67" first="3514" last="3522">
            <title>The P450-4 gene of Gibberella fujikuroi encodes ent-kaurene oxidase in the gibberellin biosynthesis pathway.</title>
            <authorList>
                <person name="Tudzynski B."/>
                <person name="Hedden P."/>
                <person name="Carrera E."/>
                <person name="Gaskin P."/>
            </authorList>
            <dbReference type="PubMed" id="11472927"/>
            <dbReference type="DOI" id="10.1128/AEM.67.8.3514-3522.2001"/>
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        <scope>FUNCTION</scope>
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    <reference key="7">
        <citation type="journal article" date="2001" name="Proc. Natl. Acad. Sci. U.S.A." volume="98" first="5838" last="5843">
            <title>The P450-1 gene of Gibberella fujikuroi encodes a multifunctional enzyme in gibberellin biosynthesis.</title>
            <authorList>
                <person name="Rojas M.C."/>
                <person name="Hedden P."/>
                <person name="Gaskin P."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="11320210"/>
            <dbReference type="DOI" id="10.1073/pnas.091096298"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
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    <reference key="8">
        <citation type="journal article" date="2002" name="J. Biol. Chem." volume="277" first="21246" last="21253">
            <title>The gibberellin 20-oxidase of Gibberella fujikuroi is a multifunctional monooxygenase.</title>
            <authorList>
                <person name="Tudzynski B."/>
                <person name="Rojas M.C."/>
                <person name="Gaskin P."/>
                <person name="Hedden P."/>
            </authorList>
            <dbReference type="PubMed" id="11943776"/>
            <dbReference type="DOI" id="10.1074/jbc.M201651200"/>
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        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2003" name="J. Biol. Chem." volume="278" first="28635" last="28643">
            <title>Characterization of the final two genes of the gibberellin biosynthesis gene cluster of Gibberella fujikuroi: des and P450-3 encode GA4 desaturase and the 13-hydroxylase, respectively.</title>
            <authorList>
                <person name="Tudzynski B."/>
                <person name="Mihlan M."/>
                <person name="Rojas M.C."/>
                <person name="Linnemannstons P."/>
                <person name="Gaskin P."/>
                <person name="Hedden P."/>
            </authorList>
            <dbReference type="PubMed" id="12750377"/>
            <dbReference type="DOI" id="10.1074/jbc.M301927200"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2005" name="Phytochemistry" volume="66" first="1296" last="1311">
            <title>Distribution of gibberellin biosynthetic genes and gibberellin production in the Gibberella fujikuroi species complex.</title>
            <authorList>
                <person name="Malonek S."/>
                <person name="Boemke C."/>
                <person name="Bornberg-Bauer E."/>
                <person name="Rojas M.C."/>
                <person name="Hedden P."/>
                <person name="Hopkins P."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="15925394"/>
            <dbReference type="DOI" id="10.1016/j.phytochem.2005.04.012"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 4 5 6 7 8 9 10 11">GA14 synthase; part of the gene cluster that mediates the biosynthesis of gibberellins (GAs), diterpenoids that may provide a selective advantage during infection of the preferred host plant, rice (PubMed:10347043, PubMed:12750377, PubMed:15925394, PubMed:23825955, PubMed:9917370). Gibberellins (GAs) are diterpenoids and are synthesized via the mevalonate pathway (PubMed:12750377). Biosynthesis of the major metabolite GA3 (gibberellic acid) from geranylgeranyl diphosphate (GGPP) requires 13 steps (PubMed:12750377). The GGPP produced by the geranylgeranyl diphosphate synthase GGS2 is converted to ent-kaurene via ent-copalyldiphosphate in a two-step cyclization reaction performed by the bifunctional ent-copalyl diphosphate synthase/ent-kaurene synthase enzyme (CPS/KS) (PubMed:10803977, PubMed:12750377, PubMed:9745028). Ent-Kaurene is metabolized to GAs by a series of oxidation reactions catalyzed by cytochrome P450 monooxygenases (PubMed:12750377, PubMed:9917370). Cytochrome P450 monooxygenase P450-4 is an ent-kaurene oxidase that catalyzes the three oxidation steps between ent-kaurene and ent-kaurenoic acid (PubMed:11472927). The highly multifunctional cytochrome P450 monooxygenase P450-1 then catalyzes four steps involving oxidation at two carbon atoms, in the main pathway from ent-kaurenoic acid to GA14 via GA12-aldehyde as well as producing kaurenolides and fujenoic acids as by-products (PubMed:11320210). The cytochrome P450 monooxygenase P450-2 then converts GA14 to GA4 by removal of C-20 (PubMed:11943776). GA4 is further converted to GA7 by the GA4 desaturase DES via 1,2-desaturation before cytochrome P450 monooxygenase P450-3, a 13-hydroxylase, hydroxylates GA7 to GA3, the final product of the GA-biosynthetic pathway (PubMed:12750377).</text>
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            <name>heme</name>
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        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Plant hormone biosynthesis; gibberellin biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="11">Expression is induced under gibberellin-producing conditions (PubMed:9917370).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 11">Leads to the loss of gibberellins production accumulates ent-kaurenoic acid but not later intermediates (PubMed:11320210, PubMed:9917370).</text>
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        <text evidence="14">Belongs to the cytochrome P450 family.</text>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
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            <dbReference type="EMBL" id="CCT69199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="901" mass="93523" checksum="D9885ECA2DC42E14" modified="2013-09-18" version="1">MQQPWKLRVLALCLATSLSGVSAQDFSTTTGTETSTDLGLVAPSTEVALPETTSTQAFVDQAPSSATSEAQVEVPTTSADEETTQINVAPASSDESSRAVEPTTNIAPPAGTTESVSIGVETSSQPEQLPDTATTNNNIPVNTATGHPVFPNPNTQETEPGTQSTDAAPVDQTPTEVSGAPSEATTGATDAATDARPPVDSTGLTEAIEPTTEAAEPTTQAAETTTQLPLPEATTETSVAAQLTSEKAPEASSDSAPAPILESTTEVKAPEASTSDEAQAPAESTTEKAEPTTEEKPEPEPTTESQEAGKPTAQAPGPKPTTEDAGSNEPTTKNEPGQTGAPSEPEKTTAPPKPTTTEDGIVTGSNGAVVTYIPEQDKDFSDFTGTTTTTDDGGAAIVIFPGGWFWKPSGNLPAGILPPPPGTNPAGAGGGTPGGGDEGEGEDDKNETQKEDEEQSTKEEEKSTAEPSTAETTAKTTEATTTTEACSAVEIEDCTRTISYYTTDGTVTHTEFGDCPTVASCATGTQATSTETVSAEAEEGEELDFEELESDIPDDFDSEPDEETVEALEDALDEGLGAGATTTEEPTASSTGTETTGEATSTEAGTTSDTKTEETSSEATTERTTTIPSTLITTTRNTESSNESSGTTSDGTTTQLTSSDMIASTTATTTMRTYYPCVPHGGPRVETPYCSCETTSDGEQYVVTAPMISGQCADYTEFPMSLYTTPPPAPEPTVFNEPFTRTDAGTVLVYESYSLSYFAVNTIKVTATVGLGEASTVSTPLPTATNWNGDGSSICSSGDKNVRNAVAGACEAALNKFEDDTVYTDYVSRYERMGSILKVLTFGKAGCTVQFSCDDYGIGMKGKDIKDLRRQQDGLTRCGNIDLSNSCKIHIDYCTECHHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E476</accession>
    <name>S0E476_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to alkaline phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429604.1">
        <property type="nucleotide sequence ID" value="XM_023575980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E476"/>
    <dbReference type="STRING" id="1279085.S0E476"/>
    <dbReference type="GeneID" id="35406763"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13309"/>
    <dbReference type="HOGENOM" id="CLU_013967_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="299"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="627" mass="70243" checksum="ADF048BADE6341DD" modified="2013-09-18" version="1">MALQTKAAKLSSVALRISALIFFRLFPAHFPSIAFALFAIYVPSYISSYFAQPEIGVLGDEVDVTLKESTVTSETPLLTEDGVAVAPEAEVVAEIVDIEEKLTVGEKVPSIANILLSGAPSARRPIASFLTFLINAILIGLTADALFRARWYYPSDDLSFVRLGYVSPSEARFIIREPDQLQMPITFEYHIKDDEPTYDTKIWLTAGYVTSTDNSTDFTTTLTVPLDSAKQNIYEWRTSNNHTGEFRSAPKVGEMPNTKDGLFTFLSTSCILPRFPYNPMEHALAIPGLRNLAGLLPKLDPQFMLFLGDFIYVDVPERFGKTIDEYRMQYRQIYASPDWAPVAQNLSWIHVLDDHEISNDWSSNTTGIYSAAVDPWHIYQANVNPPISEAAGSLNLRRNATWYEFTQGPASFFMMDTRSYRSSNNAPFNAMDKTMLGKEQLADLLAWLERPVPQGVRWKFIASSVPFTKNWPINVKDTWGGFLAERKQVLEAMWDSGARGASVIILSGDRHEFAATRFPPPTDSRWPQSAAAHEFSTSPLNQFASPFPTYKQTDDDVMMKYIPGGKSKFGSFSIEKFENGGSSLHYTLYIDGKETWKTTVEAPDAPEAVPVETVVPPSLWDKLSKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4W9</accession>
    <name>S0E4W9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to sorbitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_05625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431800.1">
        <property type="nucleotide sequence ID" value="XM_023578857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4W9"/>
    <dbReference type="STRING" id="1279085.S0E4W9"/>
    <dbReference type="GeneID" id="35399104"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05625"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="13"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT69720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="380" mass="40885" checksum="380FCF28F318D28C" modified="2013-09-18" version="1">MATERVKASVLHGEKDLRLEERELPAPSSNEVQVAVKSTGLCGSDLHYYNHFRNGDIIVREPLTLGHESAGTVVAVGSEVTHLKPGDHVALEVGLPCEACELCGEGRYNICRGMKFRSSAKANPHAQGTLQERINHPAKWCHKMPEHVTLDLGALVEPLSVAMHARDRAALPKGSTVLVLGAGAVGLLAAAVAKADQAKTVIIADILKDRLDFAINNGFADASVVVPMERPQTIEDKLAFAQKVAAMVKETQVNGEAVGEVTAVYECTGVETCVQTAIYATKPGGKVMIIGMGTPVLTIPMSAAALREVDIVGVFRYANTYKEIIELLANPPANMPDVSRLVTQRYNGMENIEEAFKMAGKVRDEQGNLVIKVVVDFDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5M1</accession>
    <name>S0E5M1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_05982</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432125.1">
        <property type="nucleotide sequence ID" value="XM_023579256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5M1"/>
    <dbReference type="STRING" id="1279085.S0E5M1"/>
    <dbReference type="GeneID" id="35399460"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05982"/>
    <dbReference type="HOGENOM" id="CLU_041037_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="339"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT70046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="447" mass="50963" checksum="AE78E001E1F7D0BE" modified="2013-09-18" version="1">MPTRTHDSPSHSRSPSPPSRATPAHRNLAVRERDSSRSASGAKRKRADTRNGEPASHRRRTVEPPASSEDEEEDEDVYDPDQPLEERRRVQQGFRDLLRDVTENTEEYLQGDSRGLHEAILRADELSKKVRQTTEATIDSRLLVSTTDLSYRKTLRLTQGSLSQGIDVDEFVSKCITYMRHGRGIMDDNAPELSSTQRQRRRTTRGDEDGEEDIGDEGDMMNWPHLGRFASLPYIRRPALPGFLLGPLSVEKKARKITKRSAPFRPNNLTETRPEVLNVEDLAKRENDLTAICGKILHQLQTLQANIQETVADLINENMDDEEQNRIMHQHGLRSTGGIDLMRFVVNPKSFGQTIENIFYVSFLVRDGRVKIDFDEFDLPALEITERDVEVEEEEPTRHGAAKHQAILSMDMETWQDIIDTFDLKEPMIAHRKEVTTSGPGARGWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6R6</accession>
    <name>S0E6R6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431517.1">
        <property type="nucleotide sequence ID" value="XM_023578483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6R6"/>
    <dbReference type="GeneID" id="35407752"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14300"/>
    <dbReference type="HOGENOM" id="CLU_2440680_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485640" evidence="1">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="90" mass="9627" checksum="EB5D794D8C5CD477" modified="2013-09-18" version="1">MKLASLIIVCLPAVSANYPWWTNSGWSKPADHVSGDCAADAQYFCGTISGTRGENPEPNAFPIRRYTCSNADTLGRGCNWQGAVGVILCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6T3</accession>
    <name>S0E6T3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to neutral amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_06575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432668.1">
        <property type="nucleotide sequence ID" value="XM_023579915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6T3"/>
    <dbReference type="STRING" id="1279085.S0E6T3"/>
    <dbReference type="GeneID" id="35400052"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06575"/>
    <dbReference type="HOGENOM" id="CLU_027816_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="49"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT70589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="462" mass="50290" checksum="F5E7DCB44E721F4B" modified="2013-09-18" version="1">MSHTEPKSAAAPEDQEKGVANAPPAFVPEPRNDDAVLGDEEAEIIDYKTLTWWQGGIVLIAETVSLGILSLPSVLATVGLVPGIVLILVMGFLSTYSGLVLAEFRAQYPFVQNFGDAVEVIGKSIGMGRVFQEVFGWAQVIFQVFVMGSHLLTWTICLNTLTNSSTCTIVWAVVGLAVFWVLNLPRTLKYTSYMSMASCMSITLAVLITVGDVAHERPIGSGSIEVARELGFTGAFLAVTNIAISFSSHSCFFTVISEFKKPEDWPKALAFLQIVDTTLYLLAAIVIYVFVGPDVPSPALSAAGSATMRKVIWGIAIPTIVIAGVIYGHVASAYIFQRIFRNTKHMVRRTKLSTMVWFGVTFGIWALSMVIAESIPVFNNLLGLICALFASWFSYGLPGIFWLWMHYGNWFKDGKQTCRFVANVVLFLTGFLICVLGLWASIEAIAEGGSKTPWSCASNAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6Z9</accession>
    <name>S0E6Z9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431592.1">
        <property type="nucleotide sequence ID" value="XM_023578611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6Z9"/>
    <dbReference type="STRING" id="1279085.S0E6Z9"/>
    <dbReference type="GeneID" id="35398883"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05404"/>
    <dbReference type="HOGENOM" id="CLU_048919_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40722" checksum="54551465F7FCEEDD" modified="2013-09-18" version="1">MRLELVLEANANAHSYRPGDCVRGELLVWGHRLKQPSEITAELQGKLSLHSNKRQIGATSSSTYTGSPCNKSDDVVHTLFQQTKKIKLATNNSTFNPQSYNHDADYYAPFDFTLPNSTCQCRCQLPPSLDRSSSGYTVKVEYAIIVTIKHRLLCRVSRLKTLRRAISFESEPSIPVLPSSNIGSLSASKLFPKLYKALASQGVSRIRSRSDECLPQYEPTLQLELLLPSPPILTPGRPSEIQLILHTPSELINSENIYIRSVEAQLETCIEAKVGLVRKTVTETQTGWSLQGMFCVDRQNFELDLGAWGQYLIIDALPTSKSCVLDTTHLLRISVGISVGGSERTQVVEASLEVIIIGAPPSYTAVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8C4</accession>
    <name>S0E8C4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to integral membrane protein, Mpv17/PMP22 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433213.1">
        <property type="nucleotide sequence ID" value="XM_023580437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8C4"/>
    <dbReference type="STRING" id="1279085.S0E8C4"/>
    <dbReference type="GeneID" id="35402294"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08818"/>
    <dbReference type="HOGENOM" id="CLU_049109_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="211" mass="23634" checksum="39DC203C84C77480" modified="2013-09-18" version="1">MPSPIVAATLQAAGLSTVSNILAQIIEARQQSRPVSLDIVQLLRFVSLTLMTAPPNYHWQGYLERTFPAYPAARGPQLGRLNDLEMQPTEDAPELKEGYEERMAQINKDREPQFSMRNTFTKWFVDCISAGAIMNTIAFLIIMGLLKGQGGSQIWSNIKTETIPIIVAGYKIWPIASIISFTFIPVQRRIVFLSFIGLLWGIYMSLVASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8K6</accession>
    <name>S0E8K6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_06048</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432186.1">
        <property type="nucleotide sequence ID" value="XM_023579329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8K6"/>
    <dbReference type="STRING" id="1279085.S0E8K6"/>
    <dbReference type="GeneID" id="35399526"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06048"/>
    <dbReference type="HOGENOM" id="CLU_003662_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000052">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="678"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT70107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1065" mass="117395" checksum="7D68D3809DB9D084" modified="2013-09-18" version="1">MPHQESAPVAKTNSADFNKLSSSLPFGQQVPLSSISGPTYVTAQLLVQQIAYKLSDKIFSYSPETFDLDIALKEWASKNEKNIHGYSTEVLPLQTRIGAGALALGYIFSPDFDVSKRHIPQSLVAPSGSLQQLRGTLDQLSLLYGVSSPFVAHVAALDYSDSKGLISNYDSALRLAEDLGLGLVASTSTYEAQHMSIFATLLAILLPTLHIYDGVRVARETLRVVDALSENGVADLYSKLSAEAGKLNTRLDTAGKVVELLKLFNDELGTVYEPFEYHGHDSPDVVLVAFGSVESQVAKGVLAKLSADGAKVGVINVRIYRPFIEEAFIKAIPASTRTIAVLGQVRNELAVEDEATQSALYSDVLTAVTFSGKFDTEPAVLDIKYTPAQTFTPQGLVNTLHKIFGNEGEAKKLPSLVQAQQFTFWDLDNSSALNSPSVIGNLLSKESTSNVYVNEIFDNLTQGGLVRSDLRASKKALEAPYDIDDANTIVVGDEKILQEVDVLKGLVEGGNVIVKLSNFKDDEVEKRLPLAFRKGLREKAAELFILDSSYSPAFEKDPLFSKLLLELSFLKVALPDYTPENIAKHILAEGHPPTLEESMDAVGLCLRHFEVPSTWAEVGADFVDPNLPATIQSNSFVVHDKEEAEETFELRDWQAAAKSLAFKEAYGTKNVLRPELSVKTSTITVKENRRLTPQDYDRNIFHIEFDLGDSGLTYKIGEALGIHAENDEEEVNQFIEFYGLNPAELVQVPAREDSALLETRTVFQALVQNVDILGKPPKRFYEALAEFATDETEKQKLEALASPAGAEDLKRRAEVDTATYVDILEEFKSARPSFHDLIKIVSPAKRREYSIASAQAVTSNSVSLMIVVVDWVDPRGRTRYGHATRYLSRLPVGAKVTASVKPSVMKLPTKDTAPLIMAGLGTGLAPFRAFVQYRAMQKAQGKEIGSILLYLGSRHQREEYLYGEEWEAYLAAGVVTLIGSAFSRDQPQKIYIQDRMRQTLKEIAKAYIQDEGSFYLCGPTWPVPDVTKVLEEAIAHEAKAAGKKIDPRKEIEKLKEEGRYVLEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA29</accession>
    <name>S0EA29_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to beta transducin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432661.1">
        <property type="nucleotide sequence ID" value="XM_023579905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA29"/>
    <dbReference type="STRING" id="1279085.S0EA29"/>
    <dbReference type="GeneID" id="35400043"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06566"/>
    <dbReference type="HOGENOM" id="CLU_000288_138_11_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="637" mass="73008" checksum="6816EB12CC80C9FD" modified="2013-09-18" version="1">MWLINTKTYKLENFVNPPCTYSILSHTWEGDEVLFQDMESLPHARSKTGWKKIEMTCEASRQANISHSWIDTCCIDKRSSAELSEAINSMFAWYKQSSVCYVYLSDLVFPRSPVDTEIPKSYAAVAFSKLEHELKTCRWFTRGWTLQELIAPGQVMFHDQNWNRIGSRAPGSDVRFIKVLEELTGIPSPVLEYKTDIATIPVAQRMSWAASRETTRIEDIAYCLLGIFDVNMPLLYGEGSKSFFRLQEEIVKNHDDLSLFAWKQDAASYGIGILRGCFANSPAEFAHWLNAHIEVNGFESGMEVTSKNVKLDGRVLKQEDYPAGIGHGVDCIFDLGVTDPDDDYFSLGILLASSSRGITHFRFKPCELIKLPPSKVLLHKDDYYDDYHSHNIYWEEKQVREELERKSISIRKSITVQEIRMMGHHQKPVFKIHWNKDVLKVLKSVNGQSTKEYIPSFECHPSSASHEDGTLIWVTDFELQIYPEHRVSFVLVNGLHLESHGYRPATGFGQAKLPRPVFWALLLGEGRAYVTSEREEWDDQSTVIEILDEIDEDISEIVRQIKRMDHHERGIFVRESLMERHSDEVGHLFDKGLARLVRVLSPLSGILPSCDVWIETEHNLLGDYGELEINIGPCHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA68</accession>
    <name>S0EA68_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432716.1">
        <property type="nucleotide sequence ID" value="XM_023579971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA68"/>
    <dbReference type="STRING" id="1279085.S0EA68"/>
    <dbReference type="GeneID" id="35400102"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06625"/>
    <dbReference type="HOGENOM" id="CLU_042940_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55725" checksum="98B787FC2345EBE4" modified="2013-09-18" version="1">MHASYFSYNLSRPYPYVWFTPVVLVGGLIATALIAFLSVATQGYETISKATSNPNTTSENRNPFSDWPSFLTANTKSLCSTTTIPIGTEFYTNNTALKYTVTKIWRGDNPKEPDALLGSLPYLNNPFQSCAVNGITIEFEGIDRSASQIALQQWGAKLRASLSCEVDTPGGTTTVNMTTTYDVNGIDNDVGTAFPGRNETAKASLWWGESLLAWYSISLTNDMHVSNEKFFRGENDTDIPPIYKGHISFTKRKTVVPSVQDIKALDFFQVSCFFVPFSNNGVSPNVYYCSREKMNNTHLIEQLSKADDSDQLMPLPGIWISADNLAKAFYFTILADLGQEDSGPNILDNVELLAHSTKGYEGIRNRTPIWGDNLRVNTTEGLAHHAFTSKDSSRKNLGIEPSVISTTFLCQIPRLKSRPTLIVSVIINTIVILSALWRLYQFLIDAILSKNDPEMMNCAGCTATASKEVEHEAMYPSGQSSQSSSRTPSGDKARYSSIRQEESL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-10-25" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA85</accession>
    <name>GA6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bifunctional ent-kaurene synthase</fullName>
            <ecNumber evidence="5">4.2.3.19</ecNumber>
            <ecNumber evidence="5">5.5.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">CPS/KS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ent-copalyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Ent-kaur-16-ene synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Gibberellin cluster-kaurene synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CPS/KS</name>
        <name type="ORF">FFUJ_14336</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Curr. Genet." volume="34" first="234" last="240">
            <title>Gibberellin biosynthesis in Gibberella fujikuroi: cloning and characterization of the copalyl diphosphate synthase gene.</title>
            <authorList>
                <person name="Tudzynski B."/>
                <person name="Kawaide H."/>
                <person name="Kamiya Y."/>
            </authorList>
            <dbReference type="PubMed" id="9745028"/>
            <dbReference type="DOI" id="10.1007/s002940050392"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Fungal Genet. Biol." volume="25" first="157" last="170">
            <title>Gibberellin biosynthetic pathway in Gibberella fujikuroi: evidence for a gene cluster.</title>
            <authorList>
                <person name="Tudzynski B."/>
                <person name="Holter K."/>
            </authorList>
            <dbReference type="PubMed" id="9917370"/>
            <dbReference type="DOI" id="10.1006/fgbi.1998.1095"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1999" name="Appl. Environ. Microbiol." volume="65" first="2558" last="2564">
            <title>Deletions in the gibberellin biosynthesis gene cluster of Gibberella fujikuroi by restriction enzyme-mediated integration and conventional transformation-mediated mutagenesis.</title>
            <authorList>
                <person name="Linnemannstoens P."/>
                <person name="Voss T."/>
                <person name="Hedden P."/>
                <person name="Gaskin P."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="10347043"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2000" name="Biosci. Biotechnol. Biochem." volume="64" first="660" last="664">
            <title>Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase.</title>
            <authorList>
                <person name="Toyomasu T."/>
                <person name="Kawaide H."/>
                <person name="Ishizaki A."/>
                <person name="Shinoda S."/>
                <person name="Otsuka M."/>
                <person name="Mitsuhashi W."/>
                <person name="Sassa T."/>
            </authorList>
            <dbReference type="PubMed" id="10803977"/>
            <dbReference type="DOI" id="10.1271/bbb.64.660"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2001" name="Appl. Environ. Microbiol." volume="67" first="3514" last="3522">
            <title>The P450-4 gene of Gibberella fujikuroi encodes ent-kaurene oxidase in the gibberellin biosynthesis pathway.</title>
            <authorList>
                <person name="Tudzynski B."/>
                <person name="Hedden P."/>
                <person name="Carrera E."/>
                <person name="Gaskin P."/>
            </authorList>
            <dbReference type="PubMed" id="11472927"/>
            <dbReference type="DOI" id="10.1128/AEM.67.8.3514-3522.2001"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2001" name="Proc. Natl. Acad. Sci. U.S.A." volume="98" first="5838" last="5843">
            <title>The P450-1 gene of Gibberella fujikuroi encodes a multifunctional enzyme in gibberellin biosynthesis.</title>
            <authorList>
                <person name="Rojas M.C."/>
                <person name="Hedden P."/>
                <person name="Gaskin P."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="11320210"/>
            <dbReference type="DOI" id="10.1073/pnas.091096298"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2002" name="J. Biol. Chem." volume="277" first="21246" last="21253">
            <title>The gibberellin 20-oxidase of Gibberella fujikuroi is a multifunctional monooxygenase.</title>
            <authorList>
                <person name="Tudzynski B."/>
                <person name="Rojas M.C."/>
                <person name="Gaskin P."/>
                <person name="Hedden P."/>
            </authorList>
            <dbReference type="PubMed" id="11943776"/>
            <dbReference type="DOI" id="10.1074/jbc.M201651200"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2003" name="J. Biol. Chem." volume="278" first="28635" last="28643">
            <title>Characterization of the final two genes of the gibberellin biosynthesis gene cluster of Gibberella fujikuroi: des and P450-3 encode GA4 desaturase and the 13-hydroxylase, respectively.</title>
            <authorList>
                <person name="Tudzynski B."/>
                <person name="Mihlan M."/>
                <person name="Rojas M.C."/>
                <person name="Linnemannstons P."/>
                <person name="Gaskin P."/>
                <person name="Hedden P."/>
            </authorList>
            <dbReference type="PubMed" id="12750377"/>
            <dbReference type="DOI" id="10.1074/jbc.M301927200"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2005" name="Phytochemistry" volume="66" first="1296" last="1311">
            <title>Distribution of gibberellin biosynthetic genes and gibberellin production in the Gibberella fujikuroi species complex.</title>
            <authorList>
                <person name="Malonek S."/>
                <person name="Boemke C."/>
                <person name="Bornberg-Bauer E."/>
                <person name="Rojas M.C."/>
                <person name="Hedden P."/>
                <person name="Hopkins P."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="15925394"/>
            <dbReference type="DOI" id="10.1016/j.phytochem.2005.04.012"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6 7 8 9 10 11 12 13">Bifunctional ent-kaurene synthase; part of the gene cluster that mediates the biosynthesis of gibberellins (GAs), diterpenoids that may provide a selective advantage during infection of the preferred host plant, rice (PubMed:10347043, PubMed:12750377, PubMed:15925394, PubMed:23825955, PubMed:9917370). Gibberellins (GAs) are diterpenoids and are synthesized via the mevalonate pathway (PubMed:12750377). Biosynthesis of the major metabolite GA3 (gibberellic acid) from geranylgeranyl diphosphate (GGPP) requires 13 steps (PubMed:12750377). The GGPP produced by the geranylgeranyl diphosphate synthase GGS2 is converted to ent-kaurene via ent-copalyldiphosphate in a two-step cyclization reaction performed by the bifunctional ent-copalyl diphosphate synthase/ent-kaurene synthase enzyme (CPS/KS) (PubMed:10803977, PubMed:12750377, PubMed:9745028). Ent-Kaurene is metabolized to GAs by a series of oxidation reactions catalyzed by cytochrome P450 monooxygenases (PubMed:12750377, PubMed:9917370). Cytochrome P450 monooxygenase P450-4 is an ent-kaurene oxidase that catalyzes the three oxidation steps between ent-kaurene and ent-kaurenoic acid (PubMed:11472927). The highly multifunctional cytochrome P450 monooxygenase P450-1 then catalyzes four steps involving oxidation at two carbon atoms, in the main pathway from ent-kaurenoic acid to GA14 via GA12-aldehyde as well as producing kaurenolides and fujenoic acids as by-products (PubMed:11320210). The cytochrome P450 monooxygenase P450-2 then converts GA14 to GA4 by removal of C-20 (PubMed:11943776). GA4 is further converted to GA7 by the GA4 desaturase DES via 1,2-desaturation before cytochrome P450 monooxygenase P450-3, a 13-hydroxylase, hydroxylates GA7 to GA3, the final product of the GA-biosynthetic pathway (PubMed:12750377).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22220"/>
            <dbReference type="ChEBI" id="CHEBI:15415"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58553"/>
            <dbReference type="EC" id="4.2.3.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate = ent-copalyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14841"/>
            <dbReference type="ChEBI" id="CHEBI:58553"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="5.5.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 12 13">Plant hormone biosynthesis; gibberellin biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="13">Expression is induced under gibberellin-producing conditions (PubMed:9917370).</text>
    </comment>
    <comment type="domain">
        <text evidence="17">The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="13">Impairs the production of gibberellins (PubMed:9917370).</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.19" evidence="5"/>
    <dbReference type="EC" id="5.5.1.13" evidence="5"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA85"/>
    <dbReference type="SMR" id="S0EA85"/>
    <dbReference type="STRING" id="1279085.S0EA85"/>
    <dbReference type="EnsemblFungi" id="CCT69398">
        <property type="protein sequence ID" value="CCT69398"/>
        <property type="gene ID" value="FFUJ_14336"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14336"/>
    <dbReference type="HOGENOM" id="CLU_005861_0_0_1"/>
    <dbReference type="BRENDA" id="4.2.3.19">
        <property type="organism ID" value="2425"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00390"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009905">
        <property type="term" value="F:ent-copalyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009899">
        <property type="term" value="F:ent-kaurene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009686">
        <property type="term" value="P:gibberellin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017057">
        <property type="entry name" value="Ent-kaurene_synthase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739:SF25">
        <property type="entry name" value="(E,E)-GERANYLLINALOOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739">
        <property type="entry name" value="ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036498">
        <property type="entry name" value="Ent-kaurene_synthase_fungi"/>
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    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000442046" description="Bifunctional ent-kaurene synthase">
        <location>
            <begin position="1"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DXDD B-type cyclization motif" evidence="1">
        <location>
            <begin position="328"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEXXE A-type cyclization motif" evidence="1">
        <location>
            <begin position="668"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="668"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
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            <label>3</label>
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        <ligand>
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    </evidence>
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    </evidence>
    <sequence length="952" mass="106762" checksum="E5E8C6D904C77A05" modified="2013-09-18" version="1">MPGKIENGTPKDLKTGNDFVSAAKSLLDRAFKSHHSYYGLCSTSCQVYDTAWVAMIPKTRDNVKQWLFPECFHYLLKTQAADGSWGSLPTTQTAGILDTASAVLALLCHAQEPLQILDVSPDEMGLRIEHGVTSLKRQLAVWNDVEDTNHIGVEFIIPALLSMLEKELDVPSFEFPCRSILERMHGEKLGHFDLEQVYGKPSSLLHSLEAFLGKLDFDRLSHHLYHGSMMASPSSTAAYLIGATKWDDEAEDYLRHVMRNGAGHGNGGISGTFPTTHFECSWIIATLLKGGFTLKQIDGDGLRGLSTILLEALRDENGVIGFAPRTADVDDTAKALLALSLVNQPVSPDIMIKVFEGKDHFTTFGSERDPSLTSNLHVLLSLLKQSNLSQYHPQILKTTLFTCRWWWGSDHCVKDKWNLSHLYPTMLLVEAFTEVLHLIDGGELSSLFDESFKCKIGLSIFQAVLRIILTQDNDGSWRGYREQTCYAILALVQARHVCFFTHMVDRLQSCVDRGFSWLKSCSFHSQDLTWTSKTAYEVGFVAEAYKLAALQSASLEVPAATIGHSVTSAVPSSDLEKYMRLVRKTALFSPLDEWGLMASIIESSFFVPLLQAQRVEIYPRDNIKVDEDKYLSIIPFTWVGCNNRSRTFASNRWLYDMMYLSLLGYQTDEYMEAVAGPVFGDVSLLHQTIDKVIDNTMGNLARANGTVHSGNGHQHESPNIGQVEDTLTRFTNSVLNHKDVLNSSSSDQDTLRREFRTFMHAHITQIEDNSRFSKQASSDAFSSPEQSYFQWVNSTGGSHVACAYSFAFSNCLMSANLLQGKDAFPSGTQKYLISSVMRHATNMCRMYNDFGSIARDNAERNVNSIHFPEFTLCNGTSQNLDERKERLLKIATYEQGYLDRALEALERQSRDDAGDRAGSKDMRKLKIVKLFCDVTDLYDQLYVIKDLSSSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAL6</accession>
    <name>S0EAL6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434002.1">
        <property type="nucleotide sequence ID" value="XM_023581282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAL6"/>
    <dbReference type="GeneID" id="35407538"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14084"/>
    <dbReference type="HOGENOM" id="CLU_115025_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485735" evidence="1">
        <location>
            <begin position="18"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="209" mass="22324" checksum="64F6FDA0B5B21C00" modified="2013-09-18" version="1">MVATKFLIMAMAAAVTATPVASAPKAESTAWSPLNIEDKIDWDGVDKKAFKDPANWNNTASAGTTKRPADSMVILAGPCDQGTCPDYNAAFDLVYTFTAVPVPPSNPGDPPLTIFSSNSDIRVNDCNNCQRTKVGSSLGGTVAGGCLDFTSCGRPQTICVDPGKYRAHRIWKDKNVKTCYNMKVENLGGCGFVKSRIVLHPNGETACNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAV1</accession>
    <name>S0EAV1_GIBF5</name>
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        <recommendedName>
            <fullName evidence="7">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_13979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434104.1">
        <property type="nucleotide sequence ID" value="XM_023581399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAV1"/>
    <dbReference type="GeneID" id="35407433"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13979"/>
    <dbReference type="HOGENOM" id="CLU_787661_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF53">
        <property type="entry name" value="DUF221 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="4">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="3">
        <location>
            <begin position="117"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40186" checksum="BA286BA8BD2159C6" modified="2013-09-18" version="1">MKDVDIQSNEVQISINERPTFTSEPPGSATGKVKSTRSELHILNQRIDKLRQEYRDGQGKHLNAAFIEFDSFANAQAAFQSIHQHQPFQMCRQVIGVKPGEIVWSCLRMKWWERLLREFVVTILIGGCVIVWIMPIAFVEFVTSSPMVSTVPGVSELPQLVVNAISGLGRALLMWALLEFVPFLMRVCAKLAGVPTLTAIEHFVHKRYFIFQTLQIFLGPMIRPTPVGFFSNIPYLNQQVPKASILYMSYILVRCLSAGATELIQLWQLFLNMTRSKRPGTPRTTYERAFELNVVHWGSVYPVMTTVGVIGKYLKQQKYQISLTFHSHELCLHCTARPCLRTDRSRICILRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECG4</accession>
    <name>S0ECG4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434724.1">
        <property type="nucleotide sequence ID" value="XM_023582146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECG4"/>
    <dbReference type="GeneID" id="35405985"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12529"/>
    <dbReference type="HOGENOM" id="CLU_054159_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035348">
        <property type="entry name" value="MoaF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024724">
        <property type="entry name" value="MoaF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10703">
        <property type="entry name" value="MoaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17409">
        <property type="entry name" value="MoaF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdenum cofactor biosynthesis protein F N-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="MoaF C-terminal" evidence="2">
        <location>
            <begin position="150"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31017" checksum="E7832EA32999FF3D" modified="2013-09-18" version="1">MVPSATSETADFVPVTKWPTLQEMADGFREHLMPASSKLQGRYFEHTYDNGWKISHDFGADAVTWKILEGEGAGLTAPAKYEAFEVRPDVFFVDFLKPDYNEVVSLIVNTVTGQAIAAVSGFKDENGERRTFTSFINAVAFGGKPVEPFQATDELIGKHVLYRYTPRDAYEHVYLNKGTMTWHCLSGTERGIADAEKCQMLKLGDNLYMLFWTETVMPVESIVVIDLEKMRSTGRFYCWDPKPKEAVHVRFGSYATVLAETSPLETLRKVSQNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECJ5</accession>
    <name>S0ECJ5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433606.1">
        <property type="nucleotide sequence ID" value="XM_023580915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECJ5"/>
    <dbReference type="STRING" id="1279085.S0ECJ5"/>
    <dbReference type="GeneID" id="35401866"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08390"/>
    <dbReference type="HOGENOM" id="CLU_021105_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="2">
        <location>
            <begin position="318"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="54950" checksum="76AFA590D0E7550D" modified="2013-09-18" version="1">MGEAAATTFASIVVLGLGFAAAGYIYHKFYKMLVLQKMNHAFEPGDPVLDLAAIGKDVPHQPGGSGEHWIYRPEQQRIDDIVMGRVVGHYYLLIGDKGSGKSSMLIDAMRKNEGDGVAMFEAHADLEIFRIRLGKALDYEFHEDYIGGYFSERGPRETTALLDIERALNKLEKVAMQKRRERGKPLVVIVNQMHLLRHDDDGRDVIELLQQRAEQWAAANIVTMVFNSDDYWVYERLKQLATRMEVLPVTDLPKQQAISALQRYRQKYWKESIDAQVLEEVYERVGGRLSFLNRVAKSRDMMGTCERIKEIEKKWFLNQCWILGPEMDDDVMDQQKWAAAAMCLAKALVDKEKDMEEHETYDPIVGHVLPTYPFHIAQQIMTRCDFIRDLDRLNLFSITSEADVRASSVPMHRAFREICAQPDFDKHLEGTIQRIADIESLGRTRELVAKDLVLGGQYEIEHNRKGITVKLKEAEKEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED03</accession>
    <name>S0ED03_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="3"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434573.1">
        <property type="nucleotide sequence ID" value="XM_023581970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED03"/>
    <dbReference type="STRING" id="1279085.S0ED03"/>
    <dbReference type="GeneID" id="35405828"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12372"/>
    <dbReference type="HOGENOM" id="CLU_055432_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT72495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="240" mass="26492" checksum="04655D618E362B76" modified="2013-09-18" version="1">MAWTCSGDTNSALIENMWKNGLITDPRVKEAFLKVDRAHYAPAMPYEDSPQPIGYSATISAPHMHASAIEHVLSYLLPSSTSPAPRVLDVGSGSGYLTHVMAELVGEKGLVVGLEHIRELKELGETNMSKSVEGRRLLESGKVRFRFGDGRKGWVEEPREGEKDEGTGWDVIHVGASAVEIHPELLEQLKAPGCMFIPVDDDKMGYNQHVWRIEKDGNGEITKKKLFGVRYVPLTEAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED71</accession>
    <name>S0ED71_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to MRPL27-mitochondrial ribosomal protein, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_06308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432422.1">
        <property type="nucleotide sequence ID" value="XM_023579619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED71"/>
    <dbReference type="STRING" id="1279085.S0ED71"/>
    <dbReference type="GeneID" id="35399785"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06308"/>
    <dbReference type="HOGENOM" id="CLU_131055_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="103" mass="11948" checksum="FB4F10D96E57F07A" modified="2013-09-18" version="1">MRPTQALSVGRYRHLRLTTKDVGKGFYKGNRTGSMGRHTKYGGYVIEWNKVRTYAVPPLKDFKLTPFVSRQVKAEPGDYKGLDKGPQDPYFYVEQWKRFNGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDD1</accession>
    <name>S0EDD1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to ankyrin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435019.1">
        <property type="nucleotide sequence ID" value="XM_023582492.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EDD1"/>
    <dbReference type="GeneID" id="35406295"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12839"/>
    <dbReference type="HOGENOM" id="CLU_243056_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1614" mass="179182" checksum="101A59C14320A61A" modified="2013-09-18" version="1">MASSKSQATGIGNIHTATVACISSLEACLSVKPLMKGGWAENRLADMNLWASGVGALARPKASLDRRLEFQPKARLVLSELLLTLKTLIEVCRIHAMDLNSAKIDTSRDEDTSTTPVDMSLVVDSESASNAESWFMELGHDIGMVSDSSSDSFTEDQSAYCDHETNLKRFMDDIDDLIDQLIMLGFAIRKSGTAARLQKADKTFNPKQDANLRTYLESIVLRNTGKRRQDNDFDQGLTSCDRMHHANALREVTAPQNHLIIANLRRRHRFNYARRHQLDLGQQVAQPIITKSVLSAPGPTQYQSTMTRDPLSQDLDKPTMAPMGSATPTGSSEVHEARTTSETTASAVEGSILNLARPSEPATSVMSTSIRKFEYPSPPPVSNFMRGFKCPCCYQTLPEMFHESSRWRKHLTEDLCPYTCPFSDCERPEVLYISRTAWRNHVLESHGEGEYWECQACSGTVFSTAKELAEHNHLIHGSTISEDEIADLQAFCRNITPPSISHCPLCLWPEGEEVLPDAMTSLEHIGSCIHEFSINSLPWAKSLSLQGTDSTTISVPNVEEWLTGTVEKLNIEEIRDLDVRGFQLLPRPPRSPIQDPMHIPHEYFAEISKYSSHAERGSHIPSGKWSEASYPQKPLLNHVRHAILIGVDISTNGTVDELAASGTDSATTTQSHPPRPSDRRGFEIAIICALTLEADVIEALFDHHWEDDGPPFDKEPGDPNAYSTGVIGRFNVVLAYMPGMGKVNAATVAANCGKSFPSIKLALVVGICGVVPFTSTKDEIVLGDVIISNGVIQYDLGRQFPEPLVRKLILPDIPGRPNLEIQGILTKLRGIRHRRQLSAKIESFLDVLRQDPELHAEYPGVAEDKLFQATYRHADDQKSCQQAKCKGDLVSRSRLLRTDVPPKPAVHFGLMASINTVIKSGKDRDLIASKENVIAFEMEGAGIWDTFPYIIIKGGCDYADSHKTKAWQRYAAATAAACAKAFLSFWNPSHQASHGQTVIPLSKQQNISARLRTHYLPFSRNKNFTGREGVISDLQRLLFADPYGQRVALFGLGGLGKTQIAIELAHRVKREEQNGRHYSVIWMPALSIASFEHACTKMIREFGIELNGQEDPKDTFKKILSSKEAGRWFLIVDNADNMECLYGTADTAGGIEQFIPGCEHGSVLFITRSHEVAISVAQKNVIKMQGMDDRDAKALLQSSLMEKDQMQDSPVIDEILHKLAYMPLAITQASAYMKVNEVSVSEYLNLLQNTDEEMVELLSYSVHNSTHCDPSQGAVMTTWIVSFQQIRHLHDDAAILLSAAAHLEPKAIPCALLPPLSSQQKMTRAIGILCRYSFLSAQKVGETLDMHSLVHLALQKWNEQEGLETATRKMAFAHVAEVFPFAYREYRELWRQYMPHALRLLTKTDGADVGDRCRLGKKVGQCLMVDGQARQAVHIFESVVEVQMTFLPENHLDRLASQRELAKAYGSNGQTKQAIKLLQHVVAVQGEILAEDHPDLLASLRELAKAYKDDGIIEEAIALLEHVVVAQAKVLPEGHLDRLESQYELATVYEANGSIKEATTLFEQVAAVQAVVVSEENPDRQLSASIRRLQSRYDKLREAKASGEPYGGETVDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDD2</accession>
    <name>S0EDD2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434967.1">
        <property type="nucleotide sequence ID" value="XM_023582430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDD2"/>
    <dbReference type="STRING" id="1279085.S0EDD2"/>
    <dbReference type="GeneID" id="35406239"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12783"/>
    <dbReference type="HOGENOM" id="CLU_092535_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="188" mass="20569" checksum="2A8013AAAF800400" modified="2013-09-18" version="1">MVSKTSRQIIWLLVSIAVLSTLFGLLLPTKLLRLVPVISSIVSLQFAYDEYAFLSCWTIPQYRVQANELLPLWFTNWGPWGTKVVFGSFTLSLASGFANTVTSWNGTGARSVVVSYLAGTLFAAGHLLIFGPKAIDLLAKIRRNDANASSTASLDLWLEMHLTRSLVVDLPAVVCFITGFLLATESVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDL0</accession>
    <name>S0EDL0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Related to ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_14075</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434010.1">
        <property type="nucleotide sequence ID" value="XM_023581292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDL0"/>
    <dbReference type="STRING" id="1279085.S0EDL0"/>
    <dbReference type="GeneID" id="35407529"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14075"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_8_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001530">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="48"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="198"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="326"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="651"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT71932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1004" mass="109985" checksum="9FED2308684B5037" modified="2013-09-18" version="1">MGSKEKQDKTGQNDGPLDTTSTTEKEPQTWPYARIFKFGGIFEHSMQAVAIFAAVCSGAGIALQNLIFGRFITVVIDFASAKTSPSHVRDETATLALYFVYLGIGRFVLSYAYNTLLTYAAYRVTRNIRHAYLRDALSQEVAFFDLGTSGSIAAQTSSNGRLIQGGISEKLGLLFQGMSTLVTAFIIAKHFIKRPYNRAFEMRDRLVRKFNTYLTDAHHVGIKISPHFGTLLSADYCIVYLGYGLALWQGIRMFSKGEIDQPGEIFTVILSVIIAATSLTMLAPYSVDFTRASVAAAKLFDLIDRESEIDSFDSTGKIPSETIGEISVDNVTFAYPTRPGIAVLDNYSVKFPAGKTTALVGQSGSGKSTVIGLLERWYNPESGTISLDGCPIDQLNLNWLRTNVRLVQQEPVLFQGTIFDNIRSGLTGTAWEDAPVEEQMHHVEEAAKLAFAHEFISKLPNGYNTQVGEHGCLLSGGQKQRIAIARSIISKPKVLLLDEATSALDPEAEGIVQKALDTVSKGRTTIVIAHKLATIQKADNIIVMMKGRIVEQGTHQSLTMCGGTYARLVQIQNLTAQSDESGDITDQSEPLDHVPMSIEPSRTLTRHETSHQSDVDGSKDLGGYDQHEQRGVISVIIRIVGQTPELRLAFIVILMACIVAGATFPGLAILIANIVEVFSLTGSEIELQGNFYAKMFIVFACGCFVAYFALGYATNVVAHNLSHKFRKSILESILRQDLQFFDREENTTGALISQIDSNPQAVLELMGYNVGLILVAVFNITAYSVLAIVYSWRLGLVVTCSGLPPLVTAGYLKIRFDAKLDRETSRLLSLSASIASEAINSIRTVSSLAIENSVLSRYSHELDLALAGSKRPVLAMMICFAFTQSIEYWFMALGFCVTKGINAANYIFWLQDLQPSVREIDENRGNGPESGDMVNIRDVHSSYPLRPEMRILRGINVNIKGQFVAFVGASGCGKSIIIALLERFYDPITGSIDIDSTCLTSLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDL4</accession>
    <name>S0EDL4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435084.1">
        <property type="nucleotide sequence ID" value="XM_023567757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDL4"/>
    <dbReference type="STRING" id="1279085.S0EDL4"/>
    <dbReference type="GeneID" id="35406360"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12904"/>
    <dbReference type="HOGENOM" id="CLU_017829_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF1">
        <property type="entry name" value="IPA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="632" mass="71793" checksum="FDAE653BCCC27250" modified="2013-09-18" version="1">MNPFRLLRDQEPDPPQYYFTLPALEDSIRPPPCPCSDCQDGFYPENAQKNPEHSYHQRLSNAQAESRARSFVDDIQKRRSRLSEKVQVFGDILITRWKKQSQAKRATLLKEAAPDLEAQQWLLPRYNYMREKYYILDRKAERRRQLLLPWLNVHVLKTNPAVLFALLHYRTAYPPQSWATFDSNQLKVSWAAGYFDVDFSAKCVVMHGDRFGSLVDWEAKAAHRGDILGYPRAILILEAQASLLKALCNIVDKILEGVDPLQTPRAEKWHDLVNHEAFRETGAIEFWSPYTNQAFSRPPMFNCDYLVTLAKSRLEETGDHLWYLQCDSDYMRRHVKIWFAPEAIKKAPEQQRAMMLTQRIVLEIESHLWWRWIEMECNNVEAVCRRFSDSSERATQLRALSTAVEKFLGSIRAYVREDLTKSDTAFSSEEAGDLLGVVSAHLSREYIQDKRRAEAEILTAIKIADKATPTDGAFNAGSEPSLTSTTIAQGREKVKTRGEQGSSGNDVTEPQAEDAGEVTKGTVITLPEEALGVIHLMFPSKDGAAKDVTWNRFVNMMTKAGFTARNNTGSAVSFKQVSGSGAGGSIVFHKPHPADKIDPILLRIMGKRMTKWFGWKRELFALQGEATSVVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEC9</accession>
    <name>S0EEC9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitination network signaling protein acrB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434290.1">
        <property type="nucleotide sequence ID" value="XM_023581620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEC9"/>
    <dbReference type="STRING" id="1279085.S0EEC9"/>
    <dbReference type="GeneID" id="35407235"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13781"/>
    <dbReference type="HOGENOM" id="CLU_005822_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="703"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="949" mass="104392" checksum="ECF3CC95B04B6CA4" modified="2013-09-18" version="1">MPRAPGSSKRQQGAASHRDNRHENGLVGSAKRSSDKKGSGLLDNSLRRSDQGTAGAAGQSTPVNGHANSPYKQCVYDASNDSRTDDLRRSSLDAVSEMSSDSSNANGLSGVEAGHRQIDVNAMKNADVHRDSGPFDLATTVLKSLPMQDTLAILIILMHVPSLSLTVIYTIFTFLTFVPPVATSSGMSINLAEIFDGNSTMPSLVTVLCVDFFFLLIWLFLWGPIQDAILDFAKPVIAITLGGGTSARDGTSRGLTTCFMWVIGHHLLRGTKAHWGRVARHIPEHWRLPQVFNNPVDSASSAYDKMSAYGWIRSVLAIHILTQGIVRYIREWYLRREKANASVGASDPEAGKPPSVISDTANEGGFATPDTEAGLNSTSTVPTSKKRRKQSTQVRLQQPLWAALASTKIVVVKEYELSHAASESAGTNATDIHNLGNAPFNNQPNQIWISYIGSDEVCFNTSHFPEIDDDEPRSVESSGEDSRPANIDTSKPFYVRVNNAVWQPTRMFPIEESPGESHEGVRWTGDIYGLRPASKYVCEFVDSQTDEVLFSTSIRTVQATQREADGVPPPVANGQRSLHPDSPALTLRTSIAAVEAKLSEERSRLKTLRKEYKNRANALKKDNELTDNQLSSAGNHDEKYRQKIRQQETQKAQAERDTQQLADQLKNFDTAPELGERKKKVEKQYSSEKKVFEAAQKAFKEFKSGLEKEIKAKEVEKSNLNTRRNKVATRIAKVENELANITDANNRGLDEAERRNQERSIWQGHVAGIEANYNERLAHVRANNANKSEEIRHLQMQLQSFHEYINSNGMSYDMMPPLDAGHSHLGPPFQLTTSSTWNPDPTAPPHYPTGLWSASDNVLPSASAPTLPSMSPWQPPPTAPPFEPRMTRSRGRSSSMLSNVSGFTQSSGEEYASPPMDSHRVKHIWASRTRASGGGSSGSGSNGDPTSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEE2</accession>
    <name>S0EEE2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Related to integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_12918</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435098.1">
        <property type="nucleotide sequence ID" value="XM_023567772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEE2"/>
    <dbReference type="GeneID" id="35406374"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12918"/>
    <dbReference type="HOGENOM" id="CLU_028200_18_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485542" evidence="15">
        <location>
            <begin position="21"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="17">
        <location>
            <begin position="111"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT73020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="444" mass="50741" checksum="0D3E72D7F909BA30" modified="2013-09-18" version="1">MRAGLLTALLSLLAFTGVFGTPSFDTSLPDCAQICFRTLTSPDCYKPSCFCTSNTFHNDLIPCLKSHCPIPQVFASLRYLDQKCERPRRDRRNDAWPYLSIHILCILCAVIRVYTKIFIVRKISPEDWLSFTSLVIYVVYFGIGHHALMSAFGQDIWWVNADDLSHALKLFWIDCPVYTLLLGMTKVTIILFYIRLCHVYTLFCQLCWACILIISLSTGALMSLNIFQCTPIRWNWDRFSGEDVDFWCMDLNKLQWSINITNIIFDLVVLVLPIPLIWKTKSTFRRKLGIVLMFSLGVVVLVASCLKMRYNVLYGHSNNITWDYMDLMVWAGIESSVSIAAPCLPTVRLFLHKVFPTSFGRIFAFGSHCERTLDQEIKAEEEEVAQWAADVEMTTDSRLRVARPRRAAISLGEGFENGGRMKKKKAMTEASRILKSVDEIPLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEL9</accession>
    <name>S0EEL9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha,alpha-trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Alpha,alpha-trehalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha,alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_12835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435178.1">
        <property type="nucleotide sequence ID" value="XM_023582488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEL9"/>
    <dbReference type="STRING" id="1279085.S0EEL9"/>
    <dbReference type="GeneID" id="35406291"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12835"/>
    <dbReference type="HOGENOM" id="CLU_006285_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.40:FF:000004">
        <property type="entry name" value="Alpha,alpha-trehalose glucohydrolase TreA/Ath1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000032">
        <property type="entry name" value="Vacuolar acid trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495851" description="alpha,alpha-trehalase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 N-terminal" evidence="12">
        <location>
            <begin position="69"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="11">
        <location>
            <begin position="432"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT73100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1043" mass="114688" checksum="49641709A67962A9" modified="2013-09-18" version="1">MLSSYLNYVILTLLSSITLATTTHDHDRIKKCYQRHSSSNHSAKASENIYKTSFPGVTWDNDNWLLSTTNLDQGHYQSRGSVANGYLGINVAAAGPFFEIDLDEEGGVINGWPLFSRRQTFATIAGFYDAQPNTNGTNFPWLLQYGYESVISGVPHWSGLILDLGDDVYLDATVDNRTVHNFTSTYDFQAGVLEWSYTWKPKAQKGSYEIKYRLFAHKLHVNRAIVDLTVVPSIDSEATIVNVIDGYSAVRSDFVKSGEDDDGAIFSAVRPVGIANVTAFIYAQVNGSKSLDLSRRKLVHGKPYVHTNESSIAQAIPVKFSAGVPVHITKYVGAASSDAFDDPEKTAKEASRKAMEEGYEKSLLSHVKEWQSVMPSDSVDSYAFPENNTLSDDEYIIDSSIIAVTNTYYLLQNTVGKNAQKAVSGAPVNVDSISVGGLTSDSYAGLIFWDADLFMQPGLTTSHPEAAQRITNYRVAKYDQAKKNIATSYAGSQNKTEFSDSAAVYPWTSGRFGNCTATGPCWDYEYHLNGDIGISLVNQWVTSGDTDFFKETLLPIYDSVANLFADLLKPNGSSWTITNMTDPDEYANHVDAGGFTMALASETLIQANKIRRQFGMTENKTQDEIASDVLFIRENGITLEFTTMNGSAIVKQADVVLMSFPLGYNDNYTDQNGLDDLDYYANKQSPDGPAMTWAIYSIVADELSPSGCSAYTYAQYSYRPYTRPPFYQLSEQLVDNATTNGGTHPAYPFLTGHGGANQVTIFGYLGLRLIPDQGLHVNPNLPPQIPYIRYRTFYWRGWPISAWSNYTHTVISRHQTTKPLDVADSRYANKSITVYAGKQGDSALRHLTFDEPVVIKNRQIGSVNTVHGNLAQCRPVKSSNLYEPGQFPLAAVDGATSTKWQPSKAAEVSSLTVSLAKKDVGSKVKGFYFDWADAPPVNVTVLFHNKTIDDPTKVYGKSSHDSDYDVVVSIKKVKLSDAYNAKTDDLDAVVMPTGNTTNVTLPEPVPLSRYATLLIAGNQALDKVDLKAGNGTGATVAEWAILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF23</accession>
    <name>S0EF23_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435378.1">
        <property type="nucleotide sequence ID" value="XM_023568018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF23"/>
    <dbReference type="GeneID" id="35403482"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10015"/>
    <dbReference type="HOGENOM" id="CLU_024399_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="697" mass="79963" checksum="B083FF25029A5353" modified="2013-09-18" version="1">MNRQNKPRSNSDWQANYERTRPKSTISKPPPTLGAGRRKGAKSTRVRTYQNIPINDIDANVVQDNGCFKLQNQPNALQAIPYTIPKHEHGVPLRYDCFIPVRETYEFFPCEPYGGAEDILGFREYRGVDMIMTKTGAYKVPTLPTHVFKPYKLLLYRGRKNAQPDEDDHHRFVYLAENKPNEMKVGDCFIRFEEVHNRMRGDVAPFMDDCELAVEYATQNRIINGNGLQAEKDAASARIQELRQQFGGLLRFRCWTVEGQQSYADEDTLCQKLFDNVQGMTTRDHLELFRVWAELLRKSQGDKLGSKEFFGRYWDAVIPDVSRPLFHDGMKILVSVTYLNYLGYSDSNPLTPEKREKTRNDVHGAVQRVIDAPRLKFKPPLPLTSIIFPDEEQNLPLGWTPLNPDNARNYRELSGNGWRTLEAHPGGLYSILINQSVRDFFLNLTLYKQLWQDGYPAPTQTNAEGLHVRLTKCERTSETVTTVDKTNLSAASANPKRVPTQDRCVADPACSANVALSMAYPDIYSDSGKAKKKRVAEWLHRSAFSYGGGITYESFVKRVVLFGNKRNGDVVKVTTNITYPHGLVGWQQNWVGDIFHQYTWLAPELSYSYENMVLSNPHISQRRPIYPMNRETAMLFETLLDKSMEEKCWGWECWNKNSAVADALMESTVVDGDQEELNKEDLKDMLHEELKERDPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF48</accession>
    <name>S0EF48_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435477.1">
        <property type="nucleotide sequence ID" value="XM_023568132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF48"/>
    <dbReference type="STRING" id="1279085.S0EF48"/>
    <dbReference type="GeneID" id="35403380"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09913"/>
    <dbReference type="HOGENOM" id="CLU_072358_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="300" mass="32973" checksum="FF4A324C9FE99656" modified="2013-09-18" version="1">MSLDPDYDVDAEEGISFGISLAPKGEEGNEFRTQNDPLDPYQRENIIERKGAVDIRCASIDIIHGLFDPEGDTLCTLLVLEFRFDPRKRARRIAHVDIELRFSASEKGVADPHVFAIAPNGNLRFDQTTQTETTTTGGDVTLGAGAAGVELGSGLKYEREVAREMTYAAAVTGSIDLRGRNYGKPNCASWTLLENPGTKTGVPVSMRTAILLKRRDEGRFQCVVTVNAKADWRTSMEWLVGTTKRDDPVLLDPTLAPTSDRYRDMEMKLGELDLNAICDITSANVIENSVKTKKIGSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF64</accession>
    <name>S0EF64_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435679.1">
        <property type="nucleotide sequence ID" value="XM_023568487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF64"/>
    <dbReference type="STRING" id="1279085.S0EF64"/>
    <dbReference type="GeneID" id="35403061"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09593"/>
    <dbReference type="HOGENOM" id="CLU_133417_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="129" mass="15040" checksum="0D980EDE39430E5B" modified="2013-09-18" version="1">MNQQPAVQNQAQAQAPNAAGQDGWDEARLEEAMKRLKLLHIKVRQLNDTIPKMIKPLVQKQPSPDVMFAAFMNSVNEAQANIKEVTDLMRDKKSREIFAQAKKRKEEEPTGIKTWEYYDHPDWFRMDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGG2</accession>
    <name>S0EGG2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435818.1">
        <property type="nucleotide sequence ID" value="XM_023568656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGG2"/>
    <dbReference type="GeneID" id="35402910"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09442"/>
    <dbReference type="HOGENOM" id="CLU_054623_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="285" mass="32232" checksum="3BF29B1DCA6867EF" modified="2013-09-18" version="1">MSSPDYVGLDRLDGYHYDSLSVALRNVLDTDIALTTFAQIIDGLPTADVVWDRYSATYEPSHPIINHKTLCEGAFEKAKTFRAQFSMAGVMVDLEKLNAYQNTKPSSRSFQLRLIEMIACALHQIGVRLSQVEKVHDPATTAGHDIESTIKWERPPDNLCRFPPKPTMFIATQFTAHDRYPNGVHDMVGYWAENRILGGVALFDHSQAWTNDDEPNLYFQCTRERVTFRVCQLLDTQQSALISFLLADTEEAIIKCPLPILPTSENRVRIDPGDAIPVNKVYRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGH7</accession>
    <name>S0EGH7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435838.1">
        <property type="nucleotide sequence ID" value="XM_023568680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGH7"/>
    <dbReference type="GeneID" id="35402888"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09420"/>
    <dbReference type="HOGENOM" id="CLU_540831_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="489" mass="54981" checksum="AEB2B6EDD32087CD" modified="2013-09-18" version="1">MATSMSANWRGIDNQLVAVEIQGPEIFYVDLTNIEKYHQLHRQITCHVPSYIYDHAYNVLGYIYYQSPGLLYINLHTVPQGAGHILWEYLVFGTLALQGNPFEGRREEYFKSIIHVHNFAEQLGMEDLKSDSAKEIFREAQDMCLVELLKLLEEVNYRSNLFPKFSVYLEKRLVSSALDYDAEGSLRAFIELRDQPSLSVAQMLLKAMAEVSNIECRSGKQDSMRDEAYRKKVAETTAVSEVIGSEECKSPKTRWIKPRNETAPVSNSVGSQFFGPVAKQEDRSGMTNHLEQPLQRAAVPDSNSYSPREPAFLPRMFLPALAPRSENNGTGLLPSFGDTSKNSRSRTPPYCHRLSPMEYTLPTEPTQLPRLQQKNRQRMAEMAFAHMTGTEHNPRRKSLDPNPSTASGELESESAAEIDNDTADEAEEACDRPVTPIGSQLNFTECILPSFDEPWQSPTSSSDTLEGEPGEVEGSMDWNAGSSESDYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGJ8</accession>
    <name>S0EGJ8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_08410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433587.1">
        <property type="nucleotide sequence ID" value="XM_023580892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGJ8"/>
    <dbReference type="STRING" id="1279085.S0EGJ8"/>
    <dbReference type="GeneID" id="35401886"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08410"/>
    <dbReference type="HOGENOM" id="CLU_004312_0_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="354"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="767"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="804"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="825"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="927"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="952"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT71508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="966" mass="108165" checksum="B6274D59EE17862B" modified="2013-09-18" version="1">MPSFLSDQDNSTIFSNNPDILNLDPTNQFGFVNKDRVNGGSIRHTRSDTINESFDESSISSTHASDVSDSTPAPMNGNSNSTRPTSMSSNSNGMPATATHIQQDDVNGVGKFGQQPMPNGTANLVDRTRQHSSDTNGINSNTASTNNHQQNNILSKPLPSEPQTIEGTSEKPPSRSFEGNHTLSLSPFPVEPRGSQSQTALSANNNTNTDATPTLHPRTNGTHRLSSPPIYNPSSAAASSTGHLQAPPGLKQRHTLDVPKYVPGRGSKDGMDTAQASGRFSPTNAGSSSGRRPSLSMGRRPTRSMQSDGPRDEIVPDEDALRWAEALRQKRASKRRRKEEEDDDRVLVGTKVDENHANWETAYNMLTGIRVSVSRTNAKLDRELTDADFETKQKSTFDIAGNELVPSAKYDFKFKDYAPWVFRRLRALFRLDPADYLMSLTGKYILSELGSPGKSGSFFYFSRDYKYIIKTIHHAEHKFLRKILKEYYQHVKDNPNMLLSQFYGLHRVKMPYGKKIHFVVMNNLFPPHRDIHTTFDLKGSTIGRDYREEDLEKNPRATLKDLNWLRRQRSLELGIQKKRMFLEQLQRDVALLKRLKIMDYSLLVGIHDVSRGNEENLRDKTLQVFNPGGEKSPDDEPNSVLLRTPSKLENQRKARELRQMIRQERPVPMGQSANKMPDELQEGQHRPGWVFGQDDGGFRATHEDNTPGDEIYYLGVIDCLTHYGIIKKIEHFWKGLSSDKTQISALPPDQYGDRFYHFIEGVTMSTEEAHREAERRHQEMIEAQRSENRVSSWNSRRRSSQAVPPMPTHVPPPPPGPRSPEAQETLERANKEAERSERHGHIENQVPDRVLTTGTSRDNRDSLQHEPILPVVQEAGENGRDDTEAKLPRSSKDLNKSLPPTRAPPPTPPKSGYAGPGSADSGYAGLSNGTGPVNQGQRVSIDSLNKELPPLPRKDGTDDNGVRLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGK3</accession>
    <name>S0EGK3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumonisin cluster-P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_09251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435997.1">
        <property type="nucleotide sequence ID" value="XM_023568869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGK3"/>
    <dbReference type="STRING" id="1279085.S0EGK3"/>
    <dbReference type="GeneID" id="35402720"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09251"/>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT73919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="599" mass="66872" checksum="A1B75B2FC335C0DA" modified="2013-09-18" version="1">MRGLNTTAVSLVLSAIWSYGLDHDGSGSLFSTLCHYIGTFCKTFPLLVVSRFIWSAIIWPTFFSPLRHLPNIPSGGWLSKETLRLVTEPRGVPQSDWINSISKEPVDLARYRSFLGVERILVISPKALAEVLATKSYNFRKPDLIVSELKQATGMGVLLAEGSEHKFQRKVLQTAFNYRHIKNLYPIFWDVAGELASALEKKVLERQQSPSDTETVIDIVDWASRATLDIIGIAGMGQGFDAIQNADSQLHQAYRMIFEPSREAIFLAVLRLIFPDRLVNWLPLQRNKRMRHGIRVIRSKCLELIRQRQEQIRHLPSAGDGIGSDILTVALLNGGFSDEKLIDQLMTFLAAGHETTATALTWAVYILCKQPEIQTRLRAEIKLNFPNPKTSPTSKGPSLNMLQEAIDSKLPYLNAVCLEVLRYFAPIPLTMREATCDTTILQTAVPAGTRIILAPRVTNRDSALWGSDANNFNPDRWLLPKDENATPTEHSEFDTGNQNRDLAGDVSATTKQTKKTGPGKSEARSNYADLTFLHGPRSCIGQSFARAEFVILLATLVLNFEFQIEDPRLLDEQNIRISRGATSRIVGGLNVRVKPIAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI35</accession>
    <name>S0EI35_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436398.1">
        <property type="nucleotide sequence ID" value="XM_023569143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI35"/>
    <dbReference type="STRING" id="1279085.S0EI35"/>
    <dbReference type="GeneID" id="35403833"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10368"/>
    <dbReference type="HOGENOM" id="CLU_107695_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="219" mass="24973" checksum="761BD4F06A26EB44" modified="2013-09-18" version="1">MIAKTPQEILAALLQTVERDIVPLTSDGVRSGSKVFGAAILSSQTLKPFTVSTNNERASPLLHGEINCIQTFYTQTYPDPKSRPNPRQDCVFFATHEPCSLCLSGITWSGFKELYYLFTYEDSRDQFAIPYDIEILEEVFRVRAEGESDEAVGKRALYNKRNKFFTAKSVKDLVEEIEDTDERKRWNAEVDRVKALYSALSDEYQKNKQSGIETSSTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIV3</accession>
    <name>S0EIV3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">20S proteasome chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434391.1">
        <property type="nucleotide sequence ID" value="XM_023581741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIV3"/>
    <dbReference type="GeneID" id="35405623"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12167"/>
    <dbReference type="HOGENOM" id="CLU_108992_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15186" checksum="CC1A9CA95162F89D" modified="2013-09-18" version="1">MATDIIELSVPLPRSLDTRIYLRLSTKAKSIVLFLTTATQDELAAPVSMGSFVYALPNRLDQAQPLSTTLYSSEASVEFTTRLAKLLARKSQLPVYVTNSISFANAGMGGTVEEEMEAFKNIAQVVSERLQLSGPRSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ71</accession>
    <name>S0EJ71_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to putative tartrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_11107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437109.1">
        <property type="nucleotide sequence ID" value="XM_023569967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ71"/>
    <dbReference type="GeneID" id="35404571"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11107"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF52">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="43"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="486" mass="54235" checksum="579E682AD418EACF" modified="2013-09-18" version="1">MADLNEKAAFDHASVKGAESTAEQTPEESEATKKLLRKCDSRLLPPLMVIYFLSFMDRTNIGNAKIQGMTEDLKMTGVDYNMALFVFFIPYIIFEVPSNIIIKRISPSLWLAGITVLWGISTVGMGLVKNVQGLIACRALLGFFEAGIVPGCIYLISMYYRRYEVQWRMSLFFSAAILAGAFSGLLAFAIAKMHDVGGLEAWRWIFILEGLLTVVVGVISKWWIPDWPETASFLNDDERSRLVARLADDSGDARMDHLNKAAWRRILTDWKIYLGTLAYFGIVNNGYAGSFFIPTILREMGYAAERAQVLTIPVYIVATIGCLSSAYLADRMRHRYGFTMFGVVMTSIGYILLLLQHQVPTAARYFALFLLVTGGYITQPVVLGWLSNTMGGHYKRSIASASQVGFGNLGGIVASNVYLTREAPEYWTGLGVSLGMVWICGIACTAFYFLAIRENKKRDRGERDHRLQAADAGNLGDDHPHWRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJL1</accession>
    <name>S0EJL1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437057.1">
        <property type="nucleotide sequence ID" value="XM_023569906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJL1"/>
    <dbReference type="STRING" id="1279085.S0EJL1"/>
    <dbReference type="GeneID" id="35404516"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11052"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="9"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="357" mass="38252" checksum="40B39CE67328B385" modified="2013-09-18" version="1">MKEAIVKKDTSVEIIDSLIPKPGPGDVLIKVVIAGTNPKDWKIPVWLGEDANTGDDIAGIVEAVGENVVGFHKGDRVAAFHEMRTPNGAFAEYATAPYYTTFHIPDSVSFEEAATIPLAAYTSVCALFQELEIPEPWSPLAKTETKRPLLIYGASTATGAYGIKLAAAANVHPIIAVGSQRSAFIKPFLDESKGDALVDYTAYKNEEELVKAIQEAFKKGGAPDGRCWKAFDSVSEDSTVRTVTKAIAGPPDSTGRKPKVTNILMKKDVEGADPSVDIVVSMVGQVHDKDENNKLLGVVWGAAFARGLREGWFTAHPYVVGKNGLEGLSDGLKDLKEGRIRAQKFLTVIGETPGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL89</accession>
    <name>S0EL89_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen debranching enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437607.1">
        <property type="nucleotide sequence ID" value="XM_023570503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL89"/>
    <dbReference type="GeneID" id="35405049"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11588"/>
    <dbReference type="HOGENOM" id="CLU_012888_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485754" description="Glycogen debranching enzyme" evidence="1">
        <location>
            <begin position="20"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="80982" checksum="E1D57571F242B1D2" modified="2013-09-18" version="1">MMPFIAVLLAVFYATLALGDSCPVITQQLSDPPYENYFYSDCNTDAQVVVTSPLPDSNLSIIGPRLIVAWPAGNSGICTFFQPQDEKNGTLAIALVNSTLGSPLGVVNHEEKGSDYPYVGVEGVLSFNSSANLTVSILGSIRNIRDFTEGPSIINPAIQNATNVTRVKNGGVLISRLWLDNVTTTNLWLEPWQNKDISLSIYNDTVSFGAGFYKFSASFNYPQLKQLSPQQVLNNQSQSLAKKEQSEVRSLSFFSYTDKLLAGGWRFLTYFGRDTMISALLLEPVLSAGNSSALEAVIGAVLERINRTDGSVCHEETIGDYATLLNLQNGIYSTAPGFTYPMIDTDYFLPVLMDRYFSATPKRVKSLLGTKAGNVDVENWNLTWGNLSYINAQKIMNITAAFEKEQSVKNLIQLKKGELVGQWRDSTYGLANGRIPFDVNCALVPAALYAISNLAKVEGVYPNNSVTRGWDSSAAKRAKIWEDNTLPLFQYNLTAETATSNLKDYLKENTFYNGSIHEDSVANYSSSGKVVDYALAINTTKDEEKIRITHTDTAFRLFLLNSTQDSQLTTFLNATANAILRPFPAGLSTPLGIVVANPAVAGNKVFTANFTNAAYHGTVVWSWQLALMAKGLERQLARCSSSQSKDDDNVPAFCSNTDVYTALKSAYNRLWDIIEDNNERLQSEVWSWSYDSKSGYKFAPLGTLPPPPGLSSGTESNVRQLWSLTFLAVKRNKDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELW5</accession>
    <name>S0ELW5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435466.1">
        <property type="nucleotide sequence ID" value="XM_023568118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELW5"/>
    <dbReference type="STRING" id="1279085.S0ELW5"/>
    <dbReference type="GeneID" id="35403392"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09925"/>
    <dbReference type="HOGENOM" id="CLU_022883_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="552" mass="64171" checksum="697D37DC283EAEB3" modified="2013-09-18" version="1">MGDLNSSNFTQPGTFDILESCIFTLIACIFTALHLDVVSNPTWQRLLFEKAKWVLLTIVIPEISILTATRQFMEAWELRSDLQKMWKQQKPSRSSPEDGFKINTKYAYFIIMGGLRFDVSDILSLRDIDPSAKKLFNGPKNGRKTVRAGPGAILLLAREGHWIKIQQNEIDDKSKANIFQKALVLIQVLWMCMQCFWRGAYGFPITLLEFHTMLHVAFAVFQYCLWIKKPLDIKEAIVVQSHGLEAEIAIMLQRQFYSRMSYRLALFKSRQTPEQPPPLGPSGRQMRWIDQIAPTEMKVGDILTSGLALYRIDVTSGYFPLENIWGPMTVIKHKIKSKDSPDFCFDLTPEFLRRWNAILSKFPDEQRENLAKTMGYNQIWRSDVEAGIPDLPEREKRILLLTRLVEFRHEPLLDREREFWEGRSIFSLDIAPHFETQGFRETYGPIWKFWRAIVQVTFAHRGSLMEGLIWLTIWCLFLNESYVLVFPNKTPEFLKKAIRQLAKFYCIYLLSVLGVAYILSGAFIVADIFASLRYCPVGVFITFQWLELFPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM63</accession>
    <name>S0EM63_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11964</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437962.1">
        <property type="nucleotide sequence ID" value="XM_023570922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM63"/>
    <dbReference type="STRING" id="1279085.S0EM63"/>
    <dbReference type="GeneID" id="35405424"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11964"/>
    <dbReference type="HOGENOM" id="CLU_028975_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="694" mass="78324" checksum="2D1C8A0368167B54" modified="2013-09-18" version="1">MTEQLQHRPHGVACTPCRRSKMKCVTSDPASLVCDRCQRLRRQCIFESHRRGLWRRDVSGRREDRARPVEEVTEDGLASGSSGSQRFSDTQAFQAPDLPGRRYSYQNRAPESVSASSRSDQSPFTPASFAMNYQDTRGLSLGAALNSDRSMEGDPGSSLDTFLQHNLPEAMDSPRTRDPVDLGLISRPSAQNLYEGFFKHFNGLVGLLDPSLYTFTYTRSRSSLLFTMILTISSRIFQPESHKPIRDHAEFLLGQALLACDSAIENIWAIICIYYWKDVKDTRGYTLIGFALRMVASAEWNMSHQSVAYDTHGLHEPGELQVRQSRDKDRVWVMLGNVDRISSYFADRPLPTTIVLENMASRQWMALTECTYLLGDGKAVASHELAGIANSVYESMVKTRVDSRVSLSTLDFGTFHKDIDDFNNRIAAWGDYWQATFATFPNSEPFQTPLIYLHRDYMRLYFNAVFLHRMLVSEDRATLQDLITHTARICFCSGLSVLRQAIEMGGLDIIYYLWDTAHLMIAFSAMMIPKLLRQDIDESSISKNEAITTITQGTSAYVSAAKSMGHSDPQTHAISAQARLLSAILVRLKAELGQANTDVMSPAMPHNLSISGLSWIEDQLDRSTLFSDGRMEPPLLDYVDMDTQTMGPEENISSFMPQMYDELDPILDDDFVNSRYLEVGLLSWKEPGIFIQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM65</accession>
    <name>S0EM65_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438179.1">
        <property type="nucleotide sequence ID" value="XM_023571116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM65"/>
    <dbReference type="GeneID" id="35407688"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14236"/>
    <dbReference type="HOGENOM" id="CLU_940247_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="296" mass="33772" checksum="25D1F7B067BB3667" modified="2013-09-18" version="1">MSGDAAQDVTDVKAEDENDTNPTIVPRDADDDINKKNALATAGTRNQGCSIHRPALRWQDAIIPELKKQEEAERGHFTRWRTNPDDIDDLTIPAFQLTEASDSAQSFDTIHATVIEPNKEAIDRLLVEYNKSVHILDQRNDVQFFEKYHKQYTSGYLDEFGRPRTKFNLRPDKSVRHAYRLPLQSPASKEATHDCEAQNCPRLYAACFIAWHGPSFRYFFSKAAEADENPSGVFFSMPRNARISVKSWEDRVQDVARDTMRETVRENNWNWAAVLASAVLKRGFTPSEYDLGGFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMI8</accession>
    <name>S0EMI8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_11881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437883.1">
        <property type="nucleotide sequence ID" value="XM_023570828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMI8"/>
    <dbReference type="STRING" id="1279085.S0EMI8"/>
    <dbReference type="GeneID" id="35405341"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11881"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF96">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="483" mass="54675" checksum="731CC9DE28B6F050" modified="2013-09-18" version="1">MLSQSFATYCLVACTTFILYYAVAKVKTALYGPLSKIPGPAIGRWTNLVVKYHTLSGRRMQYIDSLFTQYGPVVRISPTDVGINDPDAVKVIQKVSGGFQKSAWYDKTGPGMLGMRNREKHACRRRFLAHPLSNSSLPAFEPLIRAKVDLAISQMQKEHRSLGYADCHKWFSFMATDIIGDLTFGSSFRMLEQGRRSQYVEDLQAVMPTVNKRIELSPFFDLMFLLPLPQVKRFSERFQRILKYGEESIRRLQLAQLTGSLDTPIFFEKIMNPKNKENALTDLEMQQEAAELMITGTDTTSNTLTYLVWSVLQSPSIRVRLEKEVSVLSADFKDADLVKLPYLNAVVMESLRLYGAASGAHQRDVPKGGWEACGYMIPDTATVFTQAFSLHRLPEVFSTPYKFDPDRWLSPTAEMQEAYIPFGGGPRICIGIHLAYMELRVTTAAFFRKFRGAQVHVSMTNDDMELENYTLIAPKSHKCLITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EML0</accession>
    <name>S0EML0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_11906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437908.1">
        <property type="nucleotide sequence ID" value="XM_023570857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EML0"/>
    <dbReference type="STRING" id="1279085.S0EML0"/>
    <dbReference type="GeneID" id="35405366"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11906"/>
    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000739">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="199"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT75862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="333" mass="36791" checksum="F46E5B29E9F0B1DF" modified="2013-09-18" version="1">MTSPKDRVLLIGSGGIGTIAALNLERGGLAEVTSVLRSNFEVVRSKGFTIRSCQHGDIHNWRPTESLDAIPSRYDAQGRPFDYIVCCTKNIPDIIPTLCDIVAPAVTPGHTAIVLIQNGLNIERPFIHQFPNNVIVSGISRIDAHEVAHGVIEHKQNDVLHIGAFNNPTLHSKVQEAAAKRFVEIYSKGGKTTCLYQPDVDLDRWSKLVYNASFNPICALSRLNTGELQRTGRVVDTLVIPAMKEVLAVAKRAGYELPENIINDTVNSNPIDESITPSMQIDLEKGNFIEHENIIGEVVREGRERGVATPVLSILYELCCAVQWKLKEKRNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENH0</accession>
    <name>S0ENH0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to D-arabinitol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436166.1">
        <property type="nucleotide sequence ID" value="XM_023567824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENH0"/>
    <dbReference type="STRING" id="1279085.S0ENH0"/>
    <dbReference type="GeneID" id="35403657"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10191"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="254" mass="26874" checksum="67E365D89CADD561" modified="2013-09-18" version="1">MSKFSLAGRLAVVTGGGRGCGFAFAQGLAEAGADVAIFDVIEPSAPEVEQLISSYGVQIKSYIVDVTTLSSLKEGFTAVASDFNNRLDILVACAGVNKNVHFLDTEEEDFDKLFAVNAKGVYFSAKLAAQAMIENKTKCGSIILVASIASHMAIRSQRSTAYCGTKGAVRAMVAPIAAELQEHGIRVNSISPGYVKTAMTAPFPDLIEGWKDEIMNRRVAEPDDIKGACVFLASDASAYCTGSDILVDGGVTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENJ8</accession>
    <name>S0ENJ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437670.1">
        <property type="nucleotide sequence ID" value="XM_023570579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENJ8"/>
    <dbReference type="GeneID" id="35405117"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11656"/>
    <dbReference type="HOGENOM" id="CLU_1540194_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="174" mass="19579" checksum="3E7E77B78B285798" modified="2013-09-18" version="1">MENSAHQLRAELEASANATQNRPTCRELQPGDEYDELNIISNQSLRDDCGYCHVLKSAINSLADRPTTQIFVHSKEGEPIGVEYFTQKKSDSENSYTSKAGFIIYSHDKSRLVPGLGILSWKPLTYPHSFHCPSSQMIQESYKHDTVISIVLNSIGHVTEYRGYVLNACHVPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENP7</accession>
    <name>S0ENP7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cutinase</fullName>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_11791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437800.1">
        <property type="nucleotide sequence ID" value="XM_023570730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENP7"/>
    <dbReference type="STRING" id="1279085.S0ENP7"/>
    <dbReference type="GeneID" id="35405252"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11791"/>
    <dbReference type="HOGENOM" id="CLU_040058_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496275" description="cutinase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="69"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT75754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="181" mass="19161" checksum="7BDC2635F9DB7912" modified="2013-09-18" version="1">MKPTQILIALAAIVYAAPAVEQRMALRPPEIDTHSQPHVKRCGKGKPKYHGRYPYPDQTYNQLTDGTPCRNVTIIYARGMGAEGNVGAVNETGPIIFNELAGLIGPQNLAIAGVKYKADIKNVIKKGPKAGGRAMSELINRAATQCPDTKIVLVGHSAGGALLHQSAENITAEVTARIAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENQ5</accession>
    <name>S0ENQ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437820.1">
        <property type="nucleotide sequence ID" value="XM_023570754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENQ5"/>
    <dbReference type="STRING" id="1279085.S0ENQ5"/>
    <dbReference type="GeneID" id="35405273"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11812"/>
    <dbReference type="HOGENOM" id="CLU_048615_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="416" mass="47593" checksum="FDA150B03821883E" modified="2013-09-18" version="1">MALSPPATSILELLTHPNPSVSHQIPKSKTNTRSPRYYWPRQIKKWEELEDVNILKDVFGGLLLKEACRRGRTLDPYPRLHSQADCIIRDEDDTRDLIHKWNKSIVTTALDPIQDPFHPVIWSKGDPPSGKEAFPSPPQQEEKKRHQPLRKGSSKATHTRLQSLSRLQPDSGSIASSPVSCKVGDITISTCQERFPKEYKISTKWKSERIFNRGLLDDSGCFIKGKTNDNYAWPIRQAYTYCIQHMCRYGCILTAEEAFIFRIIPREDKSSNNSQNAKLLRNELINNGLMEYVSIPWKNYSRGRRQILNVWTVNLAMWFMHVLAGNNFEVDWSYVDLTAETLLIDPGDELKAASSSTARSDDGQHEVVEDNNGSVTSEESEVTEIFNSSTTKRKRDSDEDSDFEGIHLSFTKRQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENX5</accession>
    <name>S0ENX5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Crh-like protein</fullName>
            <ecNumber evidence="17">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">FFUJ_12028</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="17"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438020.1">
        <property type="nucleotide sequence ID" value="XM_023570993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENX5"/>
    <dbReference type="STRING" id="1279085.S0ENX5"/>
    <dbReference type="GeneID" id="35405488"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12028"/>
    <dbReference type="HOGENOM" id="CLU_027506_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004486113" description="Crh-like protein" evidence="21">
        <location>
            <begin position="21"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="22">
        <location>
            <begin position="16"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="264"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="280"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCT75974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="387" mass="41316" checksum="8495D504607AAC40" modified="2013-09-18" version="1">MYFSAWSKIALAGLFASAAAQTYSECNPMKKTCDPNKGLASSSYSVDFTKGADDDNWEGTGHGTVKYTSDGAEFTVAKQGDSPTIQSKWYMFFGRMEVHLKAAPGTGIVSSVVLLSDVLDEVDWEWLGGKDTDVQTNYYGKGNDAADTRSATFAVTAAQEEFHNYTIHWTKDSCEWYINGVAVRTLKYADALGGENYPQTPMRVKLGIWAGGDPDNAEGTIEWAGGETDYSAGPYTMTVQKITIENLNPAESYTYSDETGSYKSIEFDEKDSGSDDDDSSSTASETASKTSSKASSKTSSESTFTTKTATETDSDSSTTASSDDSSETESSDFKNNKAETTSAGATSSESSAAATPSTTDGSTNSAAGSWPKMWFALGSTFAAMLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP77</accession>
    <name>S0EP77_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to tol protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438245.1">
        <property type="nucleotide sequence ID" value="XM_023571191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP77"/>
    <dbReference type="STRING" id="1279085.S0EP77"/>
    <dbReference type="GeneID" id="35407620"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14168"/>
    <dbReference type="HOGENOM" id="CLU_002639_2_15_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="16"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="417" mass="47509" checksum="1AA2FBBA26559D96" modified="2013-09-18" version="1">MPRLYIPSQDARDIEYAALSYVWGGDHANFTKTTASNLDDMRRQLPWNKLSKTIQDAIIITRGLGLKYLWVDALCILQKEKINDIQHMEDWSIEAARFASYYQNAVLTIAATGSESSSRGLFLESPTLEFKPGPVVILQKSFWAGFRQSTIQPLYPDPISEIRNSALLNRAWTAQERLLSERILHFGANCIFWECSGGYVSELHPDRWDPLHKTSEFFHFKNIHTFRTKELTELWYAFVIGYSLKDISVGSDRLPALSGVATLVSTRCQQKYIAGIWESRVAEGLTWIAIRTSDIHTDGPIQSERVLPSWSWASNNGFIWFTFLHGPWESLIQVKTFHSRSKGPDTSGQVLEARLTLKGLFRMVDLSQLNTVYPYNKHAKEESTESEQQDTAKHKHIACMDGIKPAEPLGTHPRLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPA9</accession>
    <name>S0EPA9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438325.1">
        <property type="nucleotide sequence ID" value="XM_023571248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPA9"/>
    <dbReference type="GeneID" id="35407570"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14118"/>
    <dbReference type="HOGENOM" id="CLU_1337603_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="205" mass="23256" checksum="E4C60DAF13689875" modified="2013-09-18" version="1">MASAALQETWSRRNIPCLECMLFLARLGPDRIRRYSLCLESPSGAVRCRHCQHPETYSRCVAISAAALAIPTLQTTDQPDQILRGSELACIAVNLIHAVKAFQASTDEDKNAAQLISLPVANMQTHQTHARKAWESIWEVRKLDKNIDEKVREVRRLEEKLAQKTGEVKRFEEKLDEKKIAVEKLKNEIGQRKNKLRGLLNSVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPG7</accession>
    <name>S0EPG7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to bifunctional 4-hydroxyphenylacetate degradation enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437166.1">
        <property type="nucleotide sequence ID" value="XM_023570040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPG7"/>
    <dbReference type="STRING" id="1279085.S0EPG7"/>
    <dbReference type="GeneID" id="35404636"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11172"/>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="76"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="287" mass="31084" checksum="C8DB4FD27D8B92BA" modified="2013-09-18" version="1">MSSWTHLIRFRAKEDGQIHLGQLVDPTRDIGLDSVNGVEVKALLLNGDMYNATITEQVLTVDQLLAPVERGQCNYIRCLGLNYKDHAKEGGFSIPSDLEVFTKPRTALADPFPAAITIPKCAQDGSSDYEAELCVVIGKTGRDIPEHRALDCVLGYTAANDVSARNLQLAVKQWSFSKGLDNSCPIGPVLVAPSAIQDPQSLGIKAVYNGQTVQNGNTNNMIFSVAKQVSYLSRGTTLESGSIILTGTPAGIGYFRKPRISLENGGRIDIQIEKIGTLVNMVKFDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPI4</accession>
    <name>S0EPI4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-oxoadipate dioxygenase/decarboxylase</fullName>
            <ecNumber evidence="6">1.13.11.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-hydroxyglutarate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.93" evidence="6"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437251.1">
        <property type="nucleotide sequence ID" value="XM_023570084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPI4"/>
    <dbReference type="STRING" id="1279085.S0EPI4"/>
    <dbReference type="GeneID" id="35404675"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11212"/>
    <dbReference type="HOGENOM" id="CLU_026640_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16348">
        <property type="entry name" value="VOC_YdcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.80">
        <property type="entry name" value="Uncharacterised protein PF07063, DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="HGLS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047869">
        <property type="entry name" value="YdcJ_bac-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479:SF2">
        <property type="entry name" value="2-OXOADIPATE DIOXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="HGLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="479" mass="53498" checksum="0ACDFAA47D28BA1D" modified="2013-09-18" version="1">MPAINTLLISDEPSLVYRCDDFASPIDVRTAFTLSLSAVYRNEVPLYGDLVQIVHAVNTDVLSGQPGPIKDSLLSQRLDLERHGAIRLGTPFELRTMARLFAILGLKAVGYYDLSVAGLPMHGTCFRPFDLESLNQNPFRVFTTLLRPELISNANTRELALKLLSRRHIFSDRLLDLINCAEKQNWLLQMHEVEEFIQEAMKTFSWMPEASASEEEYRKLSREHPILADIASFKTAHINHLTPRTLDIDASQTQMRKQGLQVKDRIEGPPSRQCPILLRQTSFLALEEKIRFRDANGDLIQGSHRARFGEIEERGAAVTIAGRKLYDELLAKATSTICEGPGAQSLEAMDKAMNDAFKDYPDSWSELRKQGLIYCTYSGTGKGSFDITGTLSLEDLVDQGYLTAEPITYEDFLPFSAAGIFASNLDKGQNGPLQANGRPDQEGFEKALGAVLLEPEALYADIQRKSIIRCGLVPTLFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPV0</accession>
    <name>S0EPV0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to ethionine resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437831.1">
        <property type="nucleotide sequence ID" value="XM_023570766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPV0"/>
    <dbReference type="STRING" id="1279085.S0EPV0"/>
    <dbReference type="GeneID" id="35405284"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11823"/>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="670" mass="73714" checksum="6B054A675846AD02" modified="2013-09-18" version="1">MSLPTSSPFNPDGERRGRRHSIFADFIPDDLTFPPPFIDPTPNVEEILNRDIDECSSGDEHRDEEAIEDPRYVNETDVQLAFHPTGIAFGQGFSAVPPSSIDIPPPNPHDFEQSLRAEVSLLRDNDIIPPRHPPTGWKTTKLGRLYRHLFSTRVHDHDKPLFASEDSGETTPLLRDRVVRFDGIPPTPGPDEVHKRWEEALASHKIDTTWQRETKTLIQYALPLIVTFLLHYSVTVASVLTVGRLGMEELAAVNLATMTASITYYVPVQGLATCLDTLCAQAYGSGHKHLVGLQAQRMTWLLWIIMIPIAIVWWFSEPILAAAVGPGRTTQLAALYMRILIAGMPGVSAFESAKRFVQSQGLFHATTYTLFVGAPLSFLQNWLFVFKFGWGFSGAAIAMAVTHNLLPLLLILYVRLFEGYECWKGFSRKAFTNWGPMIKLALPGMIMIEAQFSVLEILTIAAGRFGTAQLAAQGVLVTVTSMSFNIPFPLAIATSTRVANLIGADLSKAARVTAKVAIFAALIVGSINLTIFTTLRKQIPAVFTEDEQVIDIASNVILVCAVMQIFDALAAVSHGLLRGIGRQSIGSYANLFAYYVVALPIALGTSFGLGWGLAGLWVGLTAGLAVVSGLEAMYLYFTDWEEAVKQAEARMRTETNRRRSSLSGLSHERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPY8</accession>
    <name>S0EPY8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to triacylglycerol lipase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438021.1">
        <property type="nucleotide sequence ID" value="XM_023570994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPY8"/>
    <dbReference type="STRING" id="1279085.S0EPY8"/>
    <dbReference type="GeneID" id="35405489"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12029"/>
    <dbReference type="HOGENOM" id="CLU_042179_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="122"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="369" mass="41284" checksum="E249423B4B18512D" modified="2013-09-18" version="1">MTLPFSKWEKLKLALRLSYAAPLTLTYILRSILITRRRGLPSRLFIVCAVLKVALGFSPRQLQYLSLPTHETYKKWIQQQIKEAKKLEQKHVARLVYDREGLEDGKSSLLWIGNRKQAKKVVLFFHGGGYAASITTGHLDWCWRAFVFAGIEKGVEVAVAVLEYTLIPEARYPVQLRQAASGLAHLLQKGIPPQDIIIGGDSAGGQLTAQLLCHLLQPQPTIPEITLVKPLAGAFLVSPWVAQSTGDASYRENSAIDMLPVHGIVAFTKELLGPEAEPAISAFPLDRDKSSLAGMTSVLSRMYVTAGAHEIFRDQVVAFKDRVQLLNPDLKLQFQYYKNCAHDFIVIEKEDGECTQDMKQWMVDLLDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHP9</accession>
    <name>S0DHP9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase I-specific transcription initiation factor RRN6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_01749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423845.1">
        <property type="nucleotide sequence ID" value="XM_023575240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHP9"/>
    <dbReference type="STRING" id="1279085.S0DHP9"/>
    <dbReference type="GeneID" id="35395234"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01749"/>
    <dbReference type="HOGENOM" id="CLU_005807_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048537">
        <property type="entry name" value="RRN6_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20640">
        <property type="entry name" value="Rrn6_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="3">
        <location>
            <begin position="115"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 helical bundle" evidence="5">
        <location>
            <begin position="602"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="4">
        <location>
            <begin position="874"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="945"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="896"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="978"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT61764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1023" mass="113420" checksum="5DC27DA12F39C11F" modified="2013-09-18" version="1">MAETRRLTDLIHGHVGSLTYIPPENATAQPGTFHSSRVTAEAPHFKVVGSSAELYPPSKTPSPEISSNLWQERRVQKRWLLQAHPEAFMGNSALSELLQENMNRYSKVEGEVSDQPLLAIGQMTNVSDHSRLTGSPMLAAATGESGELLRLARIDQSKWKWGNDKRTTLQPSVIDPDDPEEEAIWASDGLPISQVKFATSLTRYDSIRWLIVQKQTSTTILHPEYHKVPVAQSSASDSDIHQPRLSRIDPNPILTVSHKSTGGNAQVDVAFNPNSKGLPPQIAIIDECGYWSIWDILGGNKLKTRLLPYSCGHISDGLLNELPSMTEHPAEKHGVLFVGTAKVDSFWEGRSQSAGDSKGYAQRFSHLLIWNREKYEVIDLVSHIALPRLSLLARPKSKPDAILDIRVSPANQNHIFVLTMRTIYWIDLFAKSTLEEEVGPNPTILISSPRLLDREGLRMTTCLTSEGGQETAMVFVFSPTHRQLQTYWFGQSKSSGLPYWHRDTLTLPQNAGSASVDIQSLEIHPVKLTRDGDASSGFGADYYRAGVQFYQGSILSKNLGVQYCICVSVKDRNMQITLPSGRVGRNKSDEAQRWKKKRKQFIRHMGSTFVLPEGMADDNIKHVVKHNNRSKDLDKIKSRASAVLGPVSLNLDGLCRSLQKTLLAISDSLHDIPPALLSAIQENITEGVAEGRLPLKTWKETGNELGPIDLRNGFHETQPDMLDLFAGCDGQTVVTQLGRQTSQEWIRELVSLSHLNQTYVDLWLDPLEGRIPQQEEEIIRGWIADLAKDMFLATAGVMVQDVPLLGPASQEEDGRAQPTQSSVVRNKSSQSSEGGIPSSPLVATPNSANDAAIRRLQLLAPSLRLDKMENVKPSKVLSYWPTERGISTDDYISSVAVATDRKFDDARSRLQRIENKRKAQNDKYKLPPFMREGRDPKAIRTSVRTTAGNPMSSPMRPRREEPVALPPISVAPTPQTMSSQQGIPSSSQSQGLFGPSFAMSQPVSGIFGDRKKAKKNKRKGGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHZ5</accession>
    <name>S0DHZ5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_01878</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423727.1">
        <property type="nucleotide sequence ID" value="XM_023573829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHZ5"/>
    <dbReference type="STRING" id="1279085.S0DHZ5"/>
    <dbReference type="GeneID" id="35395361"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01878"/>
    <dbReference type="HOGENOM" id="CLU_147541_0_2_1"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.49.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT61646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="97" mass="10881" checksum="40AE3D3A7141C496" modified="2013-09-18" version="1">MLSSLTLPQASISQSPLLTVKMLSRAAARTTTSLVTKRGFQTTRARMSSPYHYPEGAYSNIPFNPRSKWFGLGYWTFMATGFFAPFGIAVYQTYKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI87</accession>
    <name>S0DI87_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_01428</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424140.1">
        <property type="nucleotide sequence ID" value="XM_023578817.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DI87"/>
    <dbReference type="GeneID" id="35394913"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01428"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000408">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000055">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000220">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000305">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013716">
        <property type="entry name" value="Adenylate_cyclase_G-a-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08509">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00789">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="19">
        <location>
            <begin position="723"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="20">
        <location>
            <begin position="1519"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="1859"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="208"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1202"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2229"/>
            <end position="2264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="486"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1284"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="2241"/>
            <end position="2264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT62059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2264" mass="249566" checksum="A4D985893A3849EA" modified="2013-09-18" version="1">MTRNESFNRIGSITSSSRSKIRGSSNSRRSNSNDDSPSTVASAESSTYSAVTVRSSSPSQSQSLSPSTASTTPAPASASTISTPIPTHSPTPNPAPNVDALTPTPSSSAAAPVATASPAVVAATTSNTSTFSSTPRQHQPTLAPSARPSADGNASLSNPWSSFKDEPQLSPTATNFAPRAGANAHPKDRRMSDLTNYRRELAVLETSRVPQIHQIPPTGGASPQIAPWMNQPGSPSTSSNMPTSFFNDSSDNLSLASQLSPGHQISNRQPHQHQYPSHPSQHDAPEASYFDGRRPSAASILTASSQGSKTSITRGGFRKLQGFFGEEFPGRDSSDGSLPTSLAGKDQRGRSYSHSRPTHRDRNYSNATDHTRDASPSSSRPRTPVPAPEVVPFLYQDNSDIARYGEAPVRDIMTGPDRERYVGDGSSQIPPKTSSSSRSGHSIVHLPGHHRHHKSNDDPRTLRPTMSRDDTAIGTQMSRDRGGSSAMYSTKSRGQSPTPSTRSAGMTWSTKSSQVDGQTSPGHHHGKRGIFGRLRRHHKDKDDIAKLRDLPQSTRSLQPKTSKPDLHRPSDVSTTTLPFSGTFGPGETSDVPDMRPIPGQRGATFNNKFPFAKKGRTHRPQDYVDDAIGPTDRNDPNNIYHLDTNLNDMEGILTKPPPLTPMDTSFVNNVEPERHDSIISTAPKGRWDAPDSWAVRRNTEDNSYHGPEPDEIGSPPRPEEKASPYCIRIFRSDGTFSTHSMPLDSNVTDVISQVIKKTYVVDGLENYHIIMKKHDLIRVLTPPERPLLMQKRLLQQVGYEEKDRIEDLGREDNSYLCRFMFLSARESDFHAKTTDMGLARAQKLNYVDLSGRNLVTIPISLYSKAMEIISLNLSRNLSLDVPRDFIQSCKHLRDIKFNNNEARKLPPSLSRANRLTFLDVANNRLEQLEHAELNSLTGMLKMNLANNRLKHLPSYFGAYQSLRSLNISSNFLDKFPTFLCNLPSLVDLDLSFNAIATIPHEIGGLKNLEKLLITNNRLTHAVPASFGQLVSLRELDIKYNGISSIDIISELPKLEILSADHNCVSAFVGQFESLRQLKLNSNPLNKFEIVAPVPTLKILNLSNAQLASIDSSFVNMVNLEHLILDKNYFVSLPQEIGTLSRLEHFSIANNSVGELPAQIGCLTELRVLNVRGNNISKLPMELWWANRLETFNASSNVLEHFPKPASRAPRIPGEESQPAPPPVNGRAAPLGTLSATASSEELSDDRRPSQNSSTLLSVGPSPLNAGDRKSSVVSVYGKGGRKTSVVSRSATPSAPTQTVNTRKDSGMSSRLNNTFAGSLRNLHLADNRLDDDVFDQITLLAELRVLNLSYNDEISDMPQRSIKNWPQLVELYLSGNALTTLPADDLEESSLLQALYINGNRFTNLPADISRAKNLAVLDCGSNYLKYNISNVPYDWNWNLNPNLRYLNLSGNKRLEIKQTNTGPLGPGAVNREEYTDFSRLLNLRILGLMDVTLTQPSIPDQSEDRRVRTSGSLAGHLPYGMADTLGKHEHLSTVDLVVPRFNSSETEMLLGLFDGQALSSGGSKIAKYLHENFGHIFAGELKQLKTRSNETPVDALRRSFLQLNKDLVTIAIQQSEERPLKTHRGSGQPVILTKEDLNSGGVATVVYLQSTELYVANVGDAQAMVIQTDGTHKMLTRKHDPAEPSERSRIREAGGWVSRNGRLNDLLQVSRAFGYVDLMPAVQAAPYVSNMTIREQDDIILIATGELWEYLSPGLVTDIARAERQDLMRAAQKLRDLAIAYGASGKIMVMMISVADLKRRVERSRLHRGASMSLYPSGIPDDAQVLNTRRGRRTKGDVLDSSLNRLEAEIPAPTGNVSIVFTDIKNSTTLWEMYPSAMRSAIKLHNEVMRRQLRRIGGYEVKTEGDAFMVSFPTATSALLWTFAVQMQLLDVNWPSEVLNSVSCQPVYDKDNSLIFKGLSVRMGIHFGDCVSETDPVTRRMDYFGPMVNKAARISAVADGGQITVSTDFISEIQRCLENYQDTDRGNASGSEDTFDDETYASAIRKDLRSLTSQGFEVKEMGEKKLKGLENPEVVYSLYPHALAGRIEFHLQHERKEEGGGGGDKPAVLAPGAELSIDPDAIWTLWRISLRLEMLCSSLEGNEAPGLQPPETELLERIKQRGGEVTDRFLLNFLEHQVSRIETCISTLAMRHLATGGGPIKELEDLQGPMAAILDMFMAQRKELERYRRKYGALPSPSSSEDEDDDDDDDPDTEEGSDTEQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DID3</accession>
    <name>S0DID3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_01333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424225.1">
        <property type="nucleotide sequence ID" value="XM_023579895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DID3"/>
    <dbReference type="STRING" id="1279085.S0DID3"/>
    <dbReference type="GeneID" id="35394818"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01333"/>
    <dbReference type="HOGENOM" id="CLU_055491_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF33">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT62144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="219" mass="23924" checksum="80BDBDDA8A3D0084" modified="2013-09-18" version="1">MAHYSQRKDILPLTGGCACGLIRYQLALHPLIVHCCYCTACQRQTGSICALNAVVESTALTLLSPASPTIVGSCSTPDPIPTAVQPAFARLTSAESTTRDPRPETEPLSVCLPTASGVGQTLVGCPVCLTGLWNYYADAGPHVSYVRVGTLDRPWDIQPDVHIYTQSRQSWVTVDDGKPSFEGYYTRREDYLRGDALKRYEALKPQVAEMKAELMAGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIQ7</accession>
    <name>S0DIQ7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424465.1">
        <property type="nucleotide sequence ID" value="XM_023568041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIQ7"/>
    <dbReference type="STRING" id="1279085.S0DIQ7"/>
    <dbReference type="GeneID" id="35394554"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01069"/>
    <dbReference type="HOGENOM" id="CLU_023476_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="534" mass="60177" checksum="16D8B4AA06F94B56" modified="2013-09-18" version="1">MAATNDQTPSFRCDSPPPDALPTPAIGACPELSRCLSTTSSWSHGSNDANPRDALGIEKFNRHSTGSLDTSMLKNRHPDISAISRHSSYNFDGRSRRRGYMRPQGTDFAASARSRESVMSLGSIAHLQYYFARTGLLDGKGGQLARKKQQRATLDLSSLDTNAEALPKIVGSDFDSSYASTDSSPDFSSQGFGTGLVESPIEGLDDYYEDNFSDLGGDMLPPTVSTYHHREKVVPKPPTILELKSELEQTLGDAKKALNEVEARRTGTYEEPSSAPDYPNMPAENTQGWFELQGMHILDVVTLAIRAAKIYYTAHELPDRLDSIKPEKQVRADLLAVMETLRQMATRNFKEGMREEEIKTMNDWVESVFDILKKEQEIEDAERAERVGWTWLKGDWAGRELERERAFLMSMDTVSEPLPEWKSMSPSDAKPTPFLEAMQNGVRLVKLHNAVVHKSRRRFGAIGSFHTDTQKPYRCADNLRYWVKAAELRFEVMLKVDVLGVQYNASPQAWIDFETAILKWSRHVREEITRELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIR6</accession>
    <name>S0DIR6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_01443</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424127.1">
        <property type="nucleotide sequence ID" value="XM_023578650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIR6"/>
    <dbReference type="STRING" id="1279085.S0DIR6"/>
    <dbReference type="GeneID" id="35394928"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01443"/>
    <dbReference type="HOGENOM" id="CLU_034747_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="5">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT62046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="265" mass="28956" checksum="5E206C88029D3D23" modified="2013-09-18" version="1">MNNFGVIELASAKTTSAPGWAYVPDNTISRPTAPTSRKRARNVPGLTYSDLTARQDNKIRKEAEALDKDGGKDNTIPLPIKSGRTQGKHTPNVRKILQSQKTFGNHLDDFLAMLALAEANPTNSRSAASGANNKRPSNSRRDTPSSSKPPQKDDIAMADADADAPTVLPESSKTSPPSHPGDNDPLLMSRVPDTPSDEELRRLLSHAPLNYGEVTGHRDNKYPVRSFCEVCGYWGRVRCMKCGTRVCALDCLEAHKEECVTRYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJJ2</accession>
    <name>S0DJJ2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to C6 zink-finger protein PRO1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423533.1">
        <property type="nucleotide sequence ID" value="XM_023573339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJJ2"/>
    <dbReference type="STRING" id="1279085.S0DJJ2"/>
    <dbReference type="GeneID" id="35395555"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02072"/>
    <dbReference type="HOGENOM" id="CLU_019313_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="559" mass="62274" checksum="0D721908C63A8059" modified="2013-09-18" version="1">MPAPACWTCRLRRKKCDRARPVCRGCGDLSIDCHYSPERPQWMDGGYKQKQRAKFVKAQVIQGATSRRAKGFAVQVQSLQQEYGSSAIELHEASSEDTSPSSGEPGTWVSSADTATFVRAGHPTNQKETDDFLTSLYLDTVFPHLFPLYHPQTFAGGRTWLLKAILEQPAIYHPVISISAYYFTLLLARDARQTLRTPCEQQVWDTLALHMNCSLKIIQGEMAAFNKKPCGKEDPLKQARLLGAIIQQLIFDTAMAQGADWNLHLTAALGLFRDIIETRRQADGTFNLDAFLQTVAPRSSIFDGLNLHMRPWSDDQNAFRFFSAFLIYADVISGVMSGTPPKLQPYHGMLIADEPASDGCEVPTLETEEFIGCPGWVLAVLGQISSIDASQKASRGNAFHGRADGDRGILAEIKTKLQTGLRDTQVDSQRDLAADQVAEAWIHGATLYLLMVEQRRRPSQTETKDHVQFIARLIGSPACQVSLRSIMWPFFIAGVLAEKEDEIIFIEAVSKLGPLKAFGSAKEALSLLERAWLARDETPRHDWRLSDCFGGEHRYGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJM1</accession>
    <name>S0DJM1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_00662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424835.1">
        <property type="nucleotide sequence ID" value="XM_023572563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJM1"/>
    <dbReference type="STRING" id="1279085.S0DJM1"/>
    <dbReference type="GeneID" id="35394147"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00662"/>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="167" mass="18051" checksum="D6A3BACFBF73D799" modified="2013-09-18" version="1">MSVTLHTSHGDIKVEIYCESVPKTAENFLALCGSGYYDKSPFHRLIPKFMAQTGAPATPNPPENPKGGRSIWGGAFEDEIRPALRHGARGVLSMANKGPGTNGSQFFITFDKAPHLDGLNTVFGRVIGDEGLATLAKMEAIEVDRKNRPKEPVRIENVTIHANPIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJY6</accession>
    <name>S0DJY6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423693.1">
        <property type="nucleotide sequence ID" value="XM_023573573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJY6"/>
    <dbReference type="STRING" id="1279085.S0DJY6"/>
    <dbReference type="GeneID" id="35395382"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01899"/>
    <dbReference type="HOGENOM" id="CLU_020336_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="296" mass="32846" checksum="A569979DBFB86026" modified="2013-09-18" version="1">MSTYETAQDQFITVDGIKFAYRRFGAKQGVPLTLCMHFRGTMDHWDPALINPIAAKRPIITIDNAGVGRSDGEVPKQYKQWAQYYINVLRALGVNKTDVMGFSMGGCVAQLVALNGKDLVRRLILCGTMPSTGEGVVPAPSLKAFNALSAAKTEEEHKEAFLMSMFNTSDKSRAAGEAAWKRITGARKDRTDHVDPANARRQGIAFAKFMDPKQAKDASYDRLEELRIPVLIANGSEDLLLPTENSIVIWKKLKNAQAQLHLYPDSGHGFLYQYADEFSKLINVFLGDESKLSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK37</accession>
    <name>S0DK37_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425015.1">
        <property type="nucleotide sequence ID" value="XM_023573268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK37"/>
    <dbReference type="GeneID" id="35393946"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00461"/>
    <dbReference type="HOGENOM" id="CLU_099558_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20167" checksum="AE23EF249C66C898" modified="2013-09-18" version="1">MQPALGALGHTWTAMRAMEFISLITIIGLTANFIGEMVNADYAAPSALIGTLVVACISTLYTAISYILYWDGMLPLLLSTGADIMLLVACIVVACTVGKPVSYLSCPKFPSDGNTANFVNSLFHNVYHSRGNTFAWVDPDKASCYQIKSIWGLSIALCVLFAFSAITSGCLWKRTKGASRPAPKDIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL87</accession>
    <name>S0DL87_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to glutamate-1-semialdehyde 2,1-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424183.1">
        <property type="nucleotide sequence ID" value="XM_023579395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL87"/>
    <dbReference type="STRING" id="1279085.S0DL87"/>
    <dbReference type="GeneID" id="35394863"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01378"/>
    <dbReference type="HOGENOM" id="CLU_016922_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="436" mass="47320" checksum="7DCB74427D0DCE0C" modified="2013-09-18" version="1">MSSELIQQIQAELDAATTRYIDRNSRSKALHDEALKSMPGGNTRTVLHASPFPVVIKSGKGHQITSEDGHTYTDFTGEFTAALYGHSNPVIISTIRDVLDNVGMNVGGNTAQEQIFAREVCSRFNLEHVRFCNSGTEANIHALAAARAFTKKRKVVTFSGGYHGAVIGFKGGEPEANNVDLDDWVVARYNDLDSARAAIQSEGVAAVLVEGMQGSGGGIPGHPEFLQGLQEIAGKAGVLFIMDEVMTSRLSGGGISEMRGLRPDLKTFGKYLGGGLAFGAFGGRADIMAAFDPRLPTALSHSGTFNNNTLVTHAGYAGLTKIYTPDIAAQFTRSGDELRDRLNAVTKGTRVLFTGIGTIMGVHFPRDGSRAIERSGEVEELDSLRDLFWLDMMEEGFWLVRRGFMALVLDTPMDEFDRFVSCVEAWVSKRAQMVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLD0</accession>
    <name>S0DLD0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425301.1">
        <property type="nucleotide sequence ID" value="XM_023573608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLD0"/>
    <dbReference type="STRING" id="1279085.S0DLD0"/>
    <dbReference type="GeneID" id="35393641"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00156"/>
    <dbReference type="HOGENOM" id="CLU_022883_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="620" mass="71306" checksum="22A386E8F2FAE8AF" modified="2013-09-18" version="1">MDNAWHEDPGLEFVKEQIFKHLKAHNDTALHTIRAPSFVGSPEIRGTMTILWSCVITLIACLYTALHLNVPGDTKAFPMLREKFKWVVIGLVAPEVVLYLASSQFLDARRLSKELTLLWRQQHQSETDSTLLGESEEQNGIKVPCFDIKYGFFVIMGGLEVDVSKFEHFTGHWAARGTLQSGTLRLSVNGVLQLARMGHFLPIERSKINDKSKADTLQKMLVMTQVTWMATQCIFRLGYGLPISLLEIHTMVHVICAVVMFMFWIKKPKDLLDPDWVDTTKFEDIIALMVQEQFHWNKSDEFILYAKPPADEDNDIQEQAVLVWVHSTDTSRRKYLQDEQNLPQQINWVEDDGNRIMLKTGEVLPSGLGVVARSSSWETETIQRKVLPSWYDEHRYDDPWDIPDSIWITEWVEAEPVPPTVDLYPEDIQRWNHVIRAIENLDGQIQEPQPFRGSHQRARYQDQNFHNAFLRSAGNFQYSEESRVDPDQILSFIVDNPILLVLLLVLPGLYGGIHLGTAQILFPTDLEKLLWKIASIGIIVSMPIFLLISVLGLGFSQRYLKYESITHDSWATFYKFPAHLIFLAYSLSRTFLVIESFISLRALPIGAYWTPSWLQMIPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLQ1</accession>
    <name>S0DLQ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425610.1">
        <property type="nucleotide sequence ID" value="XM_023573718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLQ1"/>
    <dbReference type="GeneID" id="35395369"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01886"/>
    <dbReference type="HOGENOM" id="CLU_785378_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="353" mass="37943" checksum="A62000AFAC9140F5" modified="2013-09-18" version="1">MAPGNRSSGKTSNLFAPDGNLFARHTGNIKAKAGESAQNAIGMGQNAILLAKVVKTLVDGKNTPEMRLKARSILMTMGGVDGIINSVDIIKTEQTHEPEPEQIGRAVWEAPHVGKLVFVTMSRINSYANVLREFVYDPEVQLINQSPGEIPCFYCVCNIHRDLSLRCCAGPSPECCVFCADDRKKCGSRACAAIESCGAAWRVVADRTHNPASGGGSTLAATIQSQDIASLRDLQALQCLISGGVELTPEEVSARVASAMPLYARNVSAATRLRSAILRLDTCEDVPVEGEGTCDELPSAFEAKPALRALLDEHSDNPVPDVPVAFVWRCSCQSSRPVYSCPSPRRRRASPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLZ2</accession>
    <name>S0DLZ2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to acyl-CoA thiolesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_01983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423619.1">
        <property type="nucleotide sequence ID" value="XM_023568529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLZ2"/>
    <dbReference type="STRING" id="1279085.S0DLZ2"/>
    <dbReference type="GeneID" id="35395466"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01983"/>
    <dbReference type="HOGENOM" id="CLU_725719_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="109"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT61538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="381" mass="41832" checksum="57C29E93ED2F6ED0" modified="2013-09-18" version="1">MSQSLIAAKQTVGEDFVCHSLQSQFFLLGSDKSPVTYSVARVREGRSYATRTVHATQEGKCIHLAVVSFARTPSKKPQHIHHASGMAAVGKPPAEERHMCQKQGIDAIAPDMLAVSFGDDSTPPQDRVLRCWIRAREDILHADDITVHQAVLVFLSDWLAIATAPYAHGYFRFPESIAESVKSSILVGTEIGMLSTLNHSICFHSSSSIRADEWMLVEVNCPWAGDERCLAIAKVFTKDGALLASYTQESRMPHLCLLSPELEDAKTILYTTADMIKVLGSEAPRLLEQDLAAPIIAATTGLAQLYVSFLIDKEMRSGNFDKASLYSRVYETGAMRQILATFTASGPGGDVTRAVKPQLWSSPENWEGTIWHALAQMKRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNJ8</accession>
    <name>S0DNJ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426235.1">
        <property type="nucleotide sequence ID" value="XM_023572038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNJ8"/>
    <dbReference type="GeneID" id="35398132"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04651"/>
    <dbReference type="HOGENOM" id="CLU_1315505_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="209" mass="23391" checksum="BFA3367FB42F2A82" modified="2013-09-18" version="1">MTSSGDRYARDASGFSSSGANITQSHTRQAPQLQRQTTAPQDAMLHQHLPQTQHSGTAYYPHQDRSYQQTVSSQGTQGYTYAPSSQPVYQGSRITQGSNDTPGDQCQVNLPGVQHSIDDPQQRTTNFVNGQQVRIESSPDEAEQNGIRRGTNTISQFEKQFTRTINTSTPASETQRDERYPQCTRQSYPGYPRTLDYRGQHDSSSQARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNM3</accession>
    <name>S0DNM3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_00396</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425078.1">
        <property type="nucleotide sequence ID" value="XM_023573341.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DNM3"/>
    <dbReference type="GeneID" id="35393881"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00396"/>
    <dbReference type="HOGENOM" id="CLU_000480_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="411"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="15">
        <location>
            <begin position="2160"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="84"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="475"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="701"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1053"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1598"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1916"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1056"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1096"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1603"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1631"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1653"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1737"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1780"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1799"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1853"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1949"/>
            <end position="1958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1982"/>
            <end position="1992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2024"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2042"/>
            <end position="2052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT62997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2518" mass="281383" checksum="65DB30E9E88F7985" modified="2013-09-18" version="1">MSRPRSGSVASTSTPIRNRRDSINSISTGQLAHALDKIHTSASQCDSLTTFNDFAPPPVAAPTSENKGIAGDLVQQGFSGLYSRLREAVGGGGTPKSPQEQTPGERSEPSSKRTSIVANHGSKASIGSLSRVDTGASLSTSSSQVIPNDGASTSQSGGTIEPRPQAQPSKPSSISLMSNQKSNPTNRQSFSKKAPSSIAADPTIAPVTVHRDPSHTTIRTEDSGGVGSSRKSISSRADLQAHLTTAESSSSLYDMKDGKLPPRSKREDTESIDESIKSPTSPRSTHHRTPSLQTRNLRSPSVTSSLLSPDSVRRKPAVIDRISRSRSPGGQNSRDSSLDRGTAEPSHVSTSAHDSVCHDSFSNNPKPQKMASGDFRIPGTVTSSEEASEQVNAQLTRMRKQVLSKEFWMKDDTVKECFLCQTPFSAFRRKHHCRTCGCIFDSKCTTVISGEKFGVQGSLRVCKRCLEVITRRFDGSGSEDSGDEQSFMPRFFGANHAKSPSNVSQPKPRDNESGVASEGSEDSRPVSRPVTTPMMAIPATRRLGESRTAAILEIDAPQLSRPGSSRSLKSLSARPHSSAGHKRHHSKHAGFLNRFKPAPEERAPFRRGIDDESVKKPKFPAFHDDNIIDPELADYMSDESSEDEQMSLFTTMTGDLQPGSLGDDKSELTPYVNANRKYRHRAGEKSISGMSFVSRGGLDELPGSLGGYRRPPRRRNTSNVSGSMHHLPSPRPKSAVFKGPSQSSELLFSLDTPHQSANQITRSDSLQHKKAPKVELNSSSLRHVDKLLHQLLDDAEITNPPAWQKALVPILLRATDDVDPDVAKGEDMDIRHYVKLKRIPGGKPGDTAYISGVVFTKNLALKSMPRRITNPRVMLVTFPIEYQRHQQHFMSLQPVIEQEKEFLRVVVQRITNLRPQVLLAEKSISGVALQYLSDANISVAYNVKHTVIEAVARCAETDIISSLDMLALPVQIGRCASFEVRTFVNNDYPGRKKSYIFLSGCTPELGCTIALRGANSTVLSKVKHIMEFMVYVVYNLKLESSLLRDESIELPEAGDSMTNSMQLQGDSARSMSVNSVDNSRDGPAVVVNHPPGDSEPPSQTTADSASITETDDTGSLNQSGQLTQERTRLMSLQEQSDPVAEDQASQVPDDVPMPTYYSDMVAKYETKILSASPYVKFTQPYLLMKTREQERRLLYLRRLRNHDYYEETDSEKLEPQKFQLIKPEMVEAIGQKAPRQIMEILRAVHDAEYDKALYNYQTQTRQWETYIQGNLDLFDPYSHQNIVVLYSVVCTETKIPCTEPSLVAINFYDEQHIDTGMDPDCTLGQYVEDLAYTMNQVCTSNGCERRMLEHHRTYVHDQFRITVFVENLPNNSALADYDGITMWTYCKICKKDTEERPMSEATYKYSFGKYLELLFWGRGLKMKGMHECPHDHHRDHVRYFSLQDARIRIHWDPIDLLEIVVPRARITWKVTNDLKLKNEIFVRMEERWAKFMASVRSRLMCIRIDSVLPDKADLCKSEVDRLTAKAKEDLPTIVKRLQDIYVNSKYYEVVPFNSIVREMLEKAGEWDQAFTKFEADFLSDKDMRQLTIMQLKKMFTDNESKESLVSNEGTPSTVDSEERPSQTFTEEEGKSTQPTDYTDNTSMEASVASSKPVDGKDVPDEDGKVEIPAEGAIERVEPLDLARTPSTPTHPPTELSQGDEAPEAQEAHDQDDQETPIADPEQTPKASGGAFDLVPLEPTETTEANEPTEPAEPGAESTEPTEPLPSPLEALPSPAPTLSDKIDQVRREQGYQAGPSAIPTPTNERGSSRKSGQAVSPPMVRATSHPVRTLSRTQSGIGKGLGIKETKTNPPDSTGSESTTEGSIRVDKKLSDRLGLRNLKDRGKATASGIPRFVHKKRESKVSTLARHFEQLSREFEKERIRDRKKRAASMRQPRAMLPRTTTKAIVEVYDDVNDAFDEPSPPSESIAEREASKRAGSIASRRSDSHHKPESVTEPLTPAEPPASIEEQQHGNPSQQIGGEEPCQERGDKTDHGEGEEITEKEEKEENDDHTIANTSQTFSDDEERTTDLEHSVPDEYLHDIKEIADSVDASDIPLELPKHQKTSLMKYLTNFWAERGASGWHQLEYPVNPSDHIFVDSDIIVREDEPSSVIALALNSDDYKGKLANIRREAQEVMQREVEGGGYVEPKSLPSDGTDWMVSETDMEKSLLRVTGTHLKYQFREGSATMTCKIFYAEQFDALRRKCGVAERIVESLSRCLKWDSKGGKTKSVFLKTLDDRLVLKSLSPIETSAFLRFAPGYFNIMAEALFHDLPSVIAKMLGFFQVFIKNPATGTDIKLDLLITENLFYDRSATRIFDLKGSMRNRKIQSTGEQNEVLLDENMVEYIYESPLFAREHSKKLLRASVWNDTLFLARQNVMDYSLMIAVDEARKELVVGIIDCIRTYTWDKKLESWIKDRGFAGGGRNRPTVTSPKEYKSRFREAMARYILQAPNCWHLFNNPQYPHYYGRARFEEPELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPM2</accession>
    <name>S0DPM2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424589.1">
        <property type="nucleotide sequence ID" value="XM_023569507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPM2"/>
    <dbReference type="GeneID" id="35394422"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00937"/>
    <dbReference type="HOGENOM" id="CLU_103881_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12716">
        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="179" mass="20006" checksum="ED1FBC787E4EF48C" modified="2013-09-18" version="1">MPSVEPPTLATHLLTALLPPELADSIQKHILHPRSPVQIIARNVLDQAQSLLDTAAPLLEPLFDRVMILLAENQGLVGVIASLVVLATVVIILNWIRRLLMWWTRMAMRIATWAFLLALAAWIWERGVFESARDMAVMGGKIVGYLAVIKDVWLQEYDRYEAQQGMAGTRGTASGRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPM9</accession>
    <name>S0DPM9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FFUJ_04384</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426477.1">
        <property type="nucleotide sequence ID" value="XM_023572337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPM9"/>
    <dbReference type="STRING" id="1279085.S0DPM9"/>
    <dbReference type="GeneID" id="35397865"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04384"/>
    <dbReference type="HOGENOM" id="CLU_074400_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="136"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCT64396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="232" mass="25732" checksum="860B4B6FD832E07E" modified="2013-09-18" version="1">MADDTTEYTESNIWESPGNDDGPPTSRPRTPRTPKTPKTPTQERPEPIDHEAALRKELEGVRSINESIEGVISTLERAGGNMNTVLSTVNNASVLLNTWTRILSQTEHNQRLILNPAWKGATEDIAEQEAEAIQKQLAAERRAAEEEQRREELRQRREEEEERRRLAATAPARGTRGTRGLRGTTRARGRAATTRSVSSSYTSESTTSSIPSTRGTSNIGRGFGARRARGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPP5</accession>
    <name>S0DPP5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_04359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426501.1">
        <property type="nucleotide sequence ID" value="XM_023572365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPP5"/>
    <dbReference type="GeneID" id="35397840"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04359"/>
    <dbReference type="HOGENOM" id="CLU_2084964_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT64420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="116" mass="12754" checksum="9A44F72AC684E894" modified="2013-09-18" version="1">MQLLCTPSISLVRAARSLRNRLINKTLVPARAAAASVRNSIHFSPFSSHSHDKLKHQARPAALGTVAVLGNGLHTGMESHAAVREGEGCSRVRKHISPFYQQWEQGSLMFQKSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPP8</accession>
    <name>S0DPP8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426506.1">
        <property type="nucleotide sequence ID" value="XM_023572371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPP8"/>
    <dbReference type="STRING" id="1279085.S0DPP8"/>
    <dbReference type="GeneID" id="35397834"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04353"/>
    <dbReference type="HOGENOM" id="CLU_066296_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28866" checksum="B8B8D33684925885" modified="2013-09-18" version="1">MDNPHDYLITSRPPSRPVDPDNADSWVMLNQGGFVKLGNERILMKLESRISCDLSVPQELRARCASFQRKSDKGTLFLTNKRIVYLPLKPTQEPKFESFSAPILKFQDSTTSSSMWWGWVWKSDCIPVSGGGIPPDIPRLEVKFTFSDGGMMDFNEAYIRLRERLYQYQEMRREMGPGADVPDEPLPAYEAPSAQPAPTTNSAGVRPNRSESAASRRAPDEPPPDYDEAQAQQLNIRLEDHIRGEIDRGAYENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPX7</accession>
    <name>S0DPX7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable ribosomal protein S16, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426567.1">
        <property type="nucleotide sequence ID" value="XM_023572445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPX7"/>
    <dbReference type="STRING" id="1279085.S0DPX7"/>
    <dbReference type="GeneID" id="35397769"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04288"/>
    <dbReference type="HOGENOM" id="CLU_100590_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_bS16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT64486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="114" mass="13009" checksum="A3FAE3D031D6C214" modified="2013-09-18" version="1">MVVKIRLARFGRRNQPFYNIVIAHARTARNSRPLEVIGTYDPIPKPDPYDTSGKLHKDIKLDSQRARYWIGVGAQPTDTAWRLLSMVGILPKKQFGPKQDNTKGVIDQGKVRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQP8</accession>
    <name>S0DQP8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426975.1">
        <property type="nucleotide sequence ID" value="XM_023572937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQP8"/>
    <dbReference type="GeneID" id="35397326"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03845"/>
    <dbReference type="HOGENOM" id="CLU_1570787_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="169" mass="18678" checksum="AA9CF83E9A7A3AEC" modified="2013-09-18" version="1">MADLMNKIKETLVPSNTENNNTGSHQESHNTGSLRETYNTSSNNTESFNNTFNANQNNQRELGSNSRVSPLEATSNQNQHTEGVRTGDRINSLVENVPGDPSSQSKPSNTSYQNDMHKSPGATLDAARAPPSALKEHLGEPIIEHDYPHESTTKRHSSVSHQEEHYNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR26</accession>
    <name>S0DR26_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426986.1">
        <property type="nucleotide sequence ID" value="XM_023572950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR26"/>
    <dbReference type="GeneID" id="35397314"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03833"/>
    <dbReference type="HOGENOM" id="CLU_2427184_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="91" mass="9804" checksum="F32F63797FEEED9C" modified="2013-09-18" version="1">MSHVCSNLKQKIIAIPYIVTELNRSGRQAEHSQRCLKKRRKPRRSVQSNPDTSATLPSAVSSHAELVEPVKGSGTLVACSASDTTNQDSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRG8</accession>
    <name>S0DRG8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_02089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427250.1">
        <property type="nucleotide sequence ID" value="XM_023573780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRG8"/>
    <dbReference type="STRING" id="1279085.S0DRG8"/>
    <dbReference type="GeneID" id="35395572"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02089"/>
    <dbReference type="HOGENOM" id="CLU_010194_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT65169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="311" mass="32911" checksum="AD74F8B06DDECCCC" modified="2013-09-18" version="1">MDSAKETAKETFHKVTHPSMDSSKNTQQPANAGLERDLEPKPQKVHLPSEGEDSVYTPSGKLAGKKALITGGDSGIGRAVAILFAMEGATVAIVYLPSEEADAQHTKAQVQKNGGKVILIASDLSLSINCKDVANLAVEELGGIDILVNNAATRQEQGDICDISEEQWASTFRVNLDSYFHLTKYVLPHLSRGGVIINSASVDSYIGVPSRLDYATSKGAVVAFTRALSNQLVKKGIRVNAVAAGPVWTPLVAAGVSEQSQQGHGLGNWTPMDRVGQPSEIATSYVFLASKESTFMSGQTLHPNGGIVVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRS4</accession>
    <name>S0DRS4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-amino-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427360.1">
        <property type="nucleotide sequence ID" value="XM_023573916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRS4"/>
    <dbReference type="STRING" id="1279085.S0DRS4"/>
    <dbReference type="GeneID" id="35395694"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02212"/>
    <dbReference type="HOGENOM" id="CLU_004498_8_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF382">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495086" evidence="1">
        <location>
            <begin position="19"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="187"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="690" mass="77492" checksum="485468913CA9075D" modified="2013-09-18" version="1">MRTSTVLWSLTSLHGLLAHAVPLNSPSVKFISPSKVSPGSAQNVVVEYSGDVDGHLTLSYGACGDETIVSETVHHIGSTHVGQHPLAKRHVDHQDKRPTRFVWLTSDNISSGCLSAFLDGELIGQSDELDVVKRLARRGEKKKSFADVAGDDSLWFDGVAYLKQKQPDDCFVTATKNKTFGILGGGMSGLLSSLILDSVGIHNWKILESSERIGGRVRTVYLNGTSPEDGQYHELGPMRFPYELTDSETNETFPFMDQRMIFQLADVLNGMNAGNKSLQVEFWDWIQSSPNTPVDTPFRRPDGSWPTKAEVASDPAYKNPAVYHNATAAEEAIEALDDFKGLTPERIRMSATNIFKAYKQAKEDGGFDYSEVSYLRDVIKADLNTTDEVTPSHIYWPMWEYETIYFLASKWVTIKGGLSRLPAAVEPHIKDRVQYNAKVNGLHYNENKTLSVSWKPTGSEPFSTPNNVENFDYVLNSVPLNLMKFWKMPRYSSLLKRAIDRTLFANACKVAVQFKTRFWEHLDRPIFGGCTRITSPQLGQVCYPSWHINSTGPGTMMASYLSDYEATVACAMSEEEHLAYIKNALIEIHGDVVEENWVGTYKRHCWENDEHHAGAFTMQIFAQQHLYLPAFYQTEFNTVFIGEAATFTHTWIFSALESAVRGSVQLLLDLGLVDEAKQVTQTWMARWIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRU8</accession>
    <name>S0DRU8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_04709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426188.1">
        <property type="nucleotide sequence ID" value="XM_023571971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRU8"/>
    <dbReference type="STRING" id="1279085.S0DRU8"/>
    <dbReference type="GeneID" id="35398190"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04709"/>
    <dbReference type="HOGENOM" id="CLU_006331_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000013">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="173"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="591"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT64107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="965" mass="108877" checksum="8AED1833D6DBE13C" modified="2013-09-18" version="1">MAESKEDLGAVFTIPDFWEPSRFLHQIDDGPQAQNPFFSPGLREDVKSELVQLGQVSLEQSGFFKLPSQLELQDKPEPEVTASTNNIQASTESLADPEIGDDIWAHTDEPEEKTPEHRTWDSFISGTPAGQQQPLVTEAGAAVYDALLGWSVDPLELKSSDVPIVDIKAYFSSLLALALGQESIFYVKQEKGRSFAPAIPSMRVTGYSKDVLQGLEKQCHRCGSMLFELRSFVNSTYVRRTSKCGVALAGVLDQILKDVQRHVALHRQTPRSLLELQSTVKGMLAILIPFQRLASKFRKGYEDQHVLSQVFHEAYSVDYGEEQLRGIMREVLQRVSSPWIEFLEEWIGTRQEKGIPLTKANVGASKGFVKVDTEKYTDDFGQEVEDIDFLLDETKMPHFMPYDIAKSIFETGKNLRFIRECHPEHPLASSAIISATDPPKVSWLYDWNAIENLEKRVAKYHDDLLGAIRDCSFRDRVNSESNGLAIDSEIANPFFREDPMSETAGGLLNTLTARMDEPLPDDVSKEDTLSQILRERLTQSPTRKSQPPTNGFDFTPHPSLLPVLSFGGIASAQSEVVNQESLRLLFNHHDLRGHLKMHRDFHLFGSGMFVSRLSHALFDPDLETAERQAGVARQGGVMGLRLGGRDTWPPASSELRLALMGVLAESFDSDNEFAKEKLASISRDASELPGDMSFAVRDLSQEEIDKCMNPDSLEALDFLRLSYKPPAALSSIITPVILTQYDRVFKLLLRIMRMVYVVNQLFLDVNARTSRWNDPEDISYRFTREAHHFVSGITSFFMDAGVAIPWEAFEAKLDKIEADLKNPSTAKGTADKVESPDRLREFHSRVLDRVMLSLFLRKRQQPVLNLLEEIFGAVLEYAKFSRSKALGKNQTTDPRELEELQRLYSNFKKKVQIFMTVCRALTEKSRSTSNKVSDDLGLKQEGIGEDHMVAQLLLKLDMGHYYTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS82</accession>
    <name>S0DS82_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acylphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 1 7">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425509.1">
        <property type="nucleotide sequence ID" value="XM_023569197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS82"/>
    <dbReference type="STRING" id="1279085.S0DS82"/>
    <dbReference type="GeneID" id="35394450"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00965"/>
    <dbReference type="HOGENOM" id="CLU_141932_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
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        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="91" mass="10455" checksum="0C00DF90B85D15E4" modified="2013-09-18" version="1">MSKRVYFAVEGRVQGVGFRYFTQKKAQEYGVTGWCRNTKDGKVEGEAQASEEVLSKFFKDVDNGPRSARVVRVSQEDRQIIEDENDFVVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS93</accession>
    <name>S0DS93_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to agglutinin isolectin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_02255</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023573964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS93"/>
    <dbReference type="STRING" id="1279085.S0DS93"/>
    <dbReference type="GeneID" id="35395737"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02255"/>
    <dbReference type="HOGENOM" id="CLU_801804_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485238" evidence="11">
        <location>
            <begin position="18"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="12">
        <location>
            <begin position="42"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="12">
        <location>
            <begin position="100"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="12">
        <location>
            <begin position="179"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT65321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="352" mass="35599" checksum="16CF07C514D6D144" modified="2013-09-18" version="1">MELSLAYFLCILSLASASFPFNFGLSSSPVLLPRAKNPTSKDGNCGSNSETNATCLTSTFGNCCSEKGFCGKTSAYCNEGCQSAFGSCSSSDDGQLVSTSGSCGATSTSNITCEGSSYGDCCSEKGYCGKNATYCGAGCQSMFGSCSSSDESSTTTATSDKTSTSTSAASTSLGAISIDGNCGSNSDTNATCQDSTFGDCCSAKGYCGKTSDYCASGCQSDFGSCDSSSSSASESASSATSSSESSSSTPSTTPSTAGLSTGAKAGIAVGSVIGGLGAIGLVAFLVLRRKNRKSSQQLTDSDAGKPNDETRYELHDERTHEMHAQNLVELPADYGRVDDRAAAGYDGAYRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSJ0</accession>
    <name>S0DSJ0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425604.1">
        <property type="nucleotide sequence ID" value="XM_023573441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSJ0"/>
    <dbReference type="GeneID" id="35393790"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00305"/>
    <dbReference type="HOGENOM" id="CLU_829118_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484484" evidence="2">
        <location>
            <begin position="18"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="335" mass="37666" checksum="0A625B39A486F7DB" modified="2013-09-18" version="1">MLFLLISLLVFPLLAQGRTEQCKFYPVISKTGGKITDCLAQDHRWKVARCLLQRNSLDYTMQCAGWKKDEKLTFDLSLHPRAPDIDIVPSLNTYDFTSKTWNPVTWKRDDDDVITFTPRGLIVAAAQYCTYLKDCRKEFFGQVLACPYEDMREFIPCLACEGTTAKDITDFERFIRRKQFGRISYDFTTEAMNWRKYADVSFCDDELDPDEDGDDDNRNIKARDQGEATVSYLYTYTRSIRYPISDPPTPDATGLPSNPTQTAGDGDEEEDEDEVASVTKDVAAGTVKRKEAAPTTTKPPETITSSPTNNGTGRYAVVDVGILGMLSVVTALLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSV6</accession>
    <name>S0DSV6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426563.1">
        <property type="nucleotide sequence ID" value="XM_023572439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSV6"/>
    <dbReference type="STRING" id="1279085.S0DSV6"/>
    <dbReference type="GeneID" id="35397774"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04293"/>
    <dbReference type="HOGENOM" id="CLU_015715_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
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            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
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            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
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        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="888" mass="98677" checksum="09CCCDECCDD8D9FF" modified="2013-09-18" version="1">MDGLSNQGLGRANSDQNVESNENIDLGNLPPLNDPTDWQLEQLEEQQRRGSSLQVANWLHHQPNSQPSQNTFITSRSLPQRQLDNYRVIGRVDDVLQRGRRPSAQAIGTPGTTGPHNRFFTPSNNVTSIDERLMQRPRPSSQSFLPFGTPSDRQIRYTDNGNHDEGRPPGLATPQGSSAFTTLSGPHTRGAYKQPPGSISQQTAWSVAGTDTSSGSKKVPKRQNSRSTDDEATGKYQHAKRYRSGHKNQSVARTSPASSGPSRLPQQSTSVPLQTIEDTQESQRQTRNIQPLSASSDSNSSNVRKDGPVRGRPNNLVMPDDFTGACETCFFWLFDPKRLSSPERHACSGRKDEISHIVTHAADHHGLIRGRDPYYSARKYLTSCQTFDPFIKAKGNCGKCDSLHEWQGQDFLDQEHYGKALCLRCWRTFDKKGMQDHMAEPLCDYNAEQPKEKKVHILYTTFCSVTVKPSGPPKNMPPRKSNHRSLANKYSRPNQRQQSNNNQTQRRPEQPTRDLRPAASKAPHGQGKAKTHSASTVSPVIQDRPRAERPSQFPQQPTRNPPNLQVAPPHASPWQQQGAQQSSQPPIALMIYNTSPELVAGMVKNLQRNGIQEVTQSSYSPMSQATSFGSLQGGSAGYSFQPQQAHPQPQAQAHTQGMFPPSYPYSSWQSSIQQPPPLAFSQAPSQNSDLTRLQPASAQNHLSQQSYDPSLMHKTATSDRQGSRMQLPTSMNSPMCDDEDSMLLGACLDAATADTNLFQDSGMPFYDRDAIVSLSDIVSQVQSTPSRVPSTAGESMGLMHRSPKVDEKLWLEHIDDFNDMNFDHMGSNPELRVTVEMVEPQFHQPEEKLKDQKPNGQISSLLRSALEQDSGYRTQSGIFDGDPNTMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTU6</accession>
    <name>S0DTU6_GIBF5</name>
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        <recommendedName>
            <fullName evidence="5">Glycoprotease family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428070.1">
        <property type="nucleotide sequence ID" value="XM_023574776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTU6"/>
    <dbReference type="STRING" id="1279085.S0DTU6"/>
    <dbReference type="GeneID" id="35396464"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02982"/>
    <dbReference type="HOGENOM" id="CLU_004045_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1008" mass="110770" checksum="50B6A459363D4F32" modified="2013-09-18" version="1">MNNDTHNQVPVHPPPYSEAQPRRREEWEDWEDDEPITPIDAGEQVSPAPLNVSTRNSKPSTRRASRASAARIVRVKSRQRQKVQNAKAGIKLITDMSTFRRQNYMPTPAGRAGKFVDAAALKALEGEPTSASVGNWNWFKKSKDQSPATASPLSSAQPAQSARTPDNKLSPDDRPIVIGLALSSEEAGSSSRYGAAPTPIETPAQPYLPRNPSSSSNLSPFPVQQKSVWSPDTPDTVSSFSTIRYASSIYSQFPSPGTTTAVNVPPVPAVPANFKKSAHQRLISLELGGRTPDDSDGGTPCTLFEEDGTSSPHKQARGKTSALTPDSAASKSRGWWDHHVVTPFMENRLTFTTSPKVYTDSPKTIRGDEWWNKQETKPPQGGYLTPSLAPGSFQTPIVKEPTPRRTPSPRFEHTQESESGPSTARASPVPETISISEKPQILVTEEEESTGEQLPAYSPPEKKSQAAPVRYRAVFPPGHPLQSQFPPSPGPVSPGLSSTMSSQRAEQLTDIPLTPAPRDNLPLPQMPLPTRPLGTSAPREYSHGEAEHATKQERQRRRNEKEEAVARRLGGFWRGRGCIPDRGCFGRTGREGRQRRRVWMIILGVLLAVIILSITLGVVLTRPKHSEEVPSIWVNLTDFPPMPTGDLTIVGPDNTVAKSGCTEPSTLWSCSLPKEQHDSVKPYKPDQPTIILQIQWDNSTRNDWKTPNEDPPSLKGRRGMGGAAYAGDTIRAREAPGFEPSPSPPKFQEMWFLGNTTDNIKSDKKGGEATPFYISLVDSVEESSRKELTKRQELDVNVSLAEVLPSPDLNENGASKPAVLLPQPVQQPVRLYDRGLPTEHYGFYTYFRRTIFLKSVTVLNDTKDGDIPLDEDGGCRETEADFIATWSETRFLVQIWTRTLAANTSKLIDPTGQGAIDGSPDLIRPGTMPYPVTVTMDTHGGDPGKKFVWAWPIDDRQKIDEENPKLLANDIGAGGTWINKRSRGDEKFGGFDGGTGGCKCQWVNWVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU87</accession>
    <name>S0DU87_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427033.1">
        <property type="nucleotide sequence ID" value="XM_023573010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU87"/>
    <dbReference type="STRING" id="1279085.S0DU87"/>
    <dbReference type="GeneID" id="35397261"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03780"/>
    <dbReference type="HOGENOM" id="CLU_464630_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484538" evidence="2">
        <location>
            <begin position="17"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="566" mass="60204" checksum="6BE4CE9BE89F8BE4" modified="2013-09-18" version="1">MRGLVILSAAVSLANAAVVERHYPVPGQEEYPAVPDTEYTPPAPGNGAYPPPAVEKPSTKPSNEYPPPEATKPSNGGAYPPPEETKPVTPPEETQPTGVYPPPEKSTDVYPPPEKSTDIYPPPEKTTGVYPPPEETTSAYTPPEETTGVYPPPEETTDVYPPPSETQPEEHSSTETPYLPPTETLPSAESSTETPYLPPSDTLPAEGTSTETGYLPPTYTKPSYNKPSYTKPGYPETSKWTTSTIYTTQVQTVTKCPPEVTNCPVGPHVTTETTKLTTSTIYTTKVHTVTKCPPEVTDCPEKPHVTTETIPVSTTVCPVTETHVVPPVHETTTKLTTSTVYTTKVHTVTKCPPEVTNCPEKPHVTTETYAVSTTVCPVTETHVVPVPPKETQPIVVPPPHPGNGTWTPPKPQPPKESHPSYPQPPAPQPPKESHPSYPQPPAPQPPKETYPAPPKETQPGVTPPKETHPAQPPAPQPPKETQPGVTPPKETQPAQPPAESHPSYPQPPAPSKPAETAPVVPAPSKPAETYPAPPATTPTQVTAGAGRVGGSVGAALFVAGFVAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV97</accession>
    <name>S0DV97_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_03416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428471.1">
        <property type="nucleotide sequence ID" value="XM_023575261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV97"/>
    <dbReference type="STRING" id="1279085.S0DV97"/>
    <dbReference type="GeneID" id="35396898"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03416"/>
    <dbReference type="HOGENOM" id="CLU_088621_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT66390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="203" mass="23111" checksum="385C676491D77417" modified="2013-09-18" version="1">MSAQALNKIAPNSPSRQNPSELETSIAQALFDLESNTSDLKVALRPLQIVSAREIEVGHGKKAIVIFVPVPSLQGFHRVQQRLTRELEKKFSDRHVLILASRRILPRPKRSARSRNTQKQKRPRSRTLTAVHDAILEDLTYPVEIVGKRVRTKEDGSKTLKVILDEKERGGVDYRLDTYSEVYRRLTGRNVNFEFPQSGPADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DW17</accession>
    <name>S0DW17_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to UPF0136 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_02759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428835.1">
        <property type="nucleotide sequence ID" value="XM_023574529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DW17"/>
    <dbReference type="GeneID" id="35396241"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02759"/>
    <dbReference type="HOGENOM" id="CLU_096652_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF15">
        <property type="entry name" value="UPF0136 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03720)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="110" mass="11560" checksum="17E584F41CF55036" modified="2013-09-18" version="1">MATVNYHDLELPAYILGALTAGGGIMGYARTRSVPSIVAGCAVGFLYALGGYRIQNDQPYGVELGLLASVVLGGSAFPRALRLRKPVPILLSVISAFGLFTYGSALRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWA4</accession>
    <name>S0DWA4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to steroid monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_02168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428867.1">
        <property type="nucleotide sequence ID" value="XM_023573867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWA4"/>
    <dbReference type="STRING" id="1279085.S0DWA4"/>
    <dbReference type="GeneID" id="35395650"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02168"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF12">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT66786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="602" mass="67447" checksum="31B5E31CF12C2457" modified="2013-09-18" version="1">MANSSTNSTPGSSAREDAIRFYQIAAQRQPTPAETAAYKSIDPLAFEMSRVPMRTPRPLKIVCCGAGISGLNLAHEVETGGFANCELKIFEKNSDLGGTWFENRYPGCACDIPIHNYQFTWAPYPHFPSFYTGAQDIYKYLKEVAEQHNLRKYIRLSHKIIGAKWIEERQKWQVQIVQTDGRELVVSDGETKDGEQGEPFIEECDVFINASGAYNNWRWPTIPNREAYRGNMMHSASWPDVDYVTGRTVTLIGNGSSGIQILPAILDQADKIYVMLRSKTWVTPALANRFAGENGANKIYTDDEKDNWSKDPEGYYAYRKEIENELNARFRLYLKDSQAQQMGKEATKKQMTARLSAKPELVNDLIPDFPVGCRRPTPGSGFLEALCSPKVEIIWGEIDTFNETGLKTASGKQVDSDTIICATGFNMGFIPRFSIVGLNGCDLREVWTQELPTAYLSVTVDKMPNYFVMMGPQSPLGHGSITGSIERLTKYIRKLVSKLQTEAYASLVPTEAATKAWLAHALKWMEKTVWVENCASSFKNGSSGRTVVSLHPGSRLHFFDLLEQPRYEDFEWTSLSNDPLSMFAWLADGFTADESSAAADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYI9</accession>
    <name>S0DYI9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_14547</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429687.1">
        <property type="nucleotide sequence ID" value="XM_023576493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYI9"/>
    <dbReference type="STRING" id="1279085.S0DYI9"/>
    <dbReference type="GeneID" id="35407928"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14547"/>
    <dbReference type="HOGENOM" id="CLU_060983_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF60">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="15"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT67606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="294" mass="32990" checksum="0143D953FBDD3D35" modified="2013-09-18" version="1">MLVPHTDPASKPKPYKRIIFYHQTQYKDDRYISLQPTILPATGVTHVIVAAIHLNTPERITLNDDLYDADKFIPLWDEVRQLQAAGVKVLGMLGGAAQGSYTKMDGSLEGFHRWYQPLRKMIAWAGFDGLDLDIEEAMSLGGVVRLIDHLKTDFGQSFLITLAPVAPALLNRQNLGGFNMEELEKGLGSRIAWYNTQFYCGWGDMSKTHDYDTIIARGWPQEKVVIGLVTNPANCSGHVKEAKLRACLKELVSRYPRIGGVMGWEYYNSVTEASPEIGSPWKWAEMINDMLNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYN9</accession>
    <name>S0DYN9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to putative monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_14651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429752.1">
        <property type="nucleotide sequence ID" value="XM_023576609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYN9"/>
    <dbReference type="STRING" id="1279085.S0DYN9"/>
    <dbReference type="GeneID" id="35408031"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14651"/>
    <dbReference type="HOGENOM" id="CLU_006937_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="535" mass="60768" checksum="BFC933ECB1EFA650" modified="2013-09-18" version="1">MNQTDVLIIGAGMSGIGLGVQLIRKFGTRNFEIIEKDSAMAGTWRVNSYPGCGCDVPSHFYSYSFALNPNWSQAYAMQPEIQTYFNDVAKKYDIERHVRFNLAVESARWDETTGTWETTIRDVKTSEVMTVRSKVLISAVGALSIPKECDIPGTSDFEGRIFHTAKWDHSFDWKDKEVVIVGNGCSVTQILPVISSGDAAVKKATQFARQAHWLAERPNPAYSTTFKWAMRWFPLAMRLYRAWLYYLKERDFAGFRVAEGLQVRNQWARDTTDYIRRTAPAKYLDFLVPRTEVGCKRRVNDTDYLACLHKDNVELVYSDPIQKIEAKGVRTSSGRLVTADAIILAHGFETQKPLFPMKIFGKDGVSINEHWNQVSEGAASSYFGTYLSEFPNFFIMMGPNTLSGHLSVIYTTECQINYTMRVLRPILTGKADIVEVTPEAEKKDIENVQEKAKRLVWATGCTSWFIDEKTNRNTVMFPDWQFKFWLRSVFVAWNDLEYRSVSTNKPVKMSRVSLSLLAVAGLVGLGSFCSHILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZP0</accession>
    <name>S0DZP0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428963.1">
        <property type="nucleotide sequence ID" value="XM_023575690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZP0"/>
    <dbReference type="STRING" id="1279085.S0DZP0"/>
    <dbReference type="GeneID" id="35406506"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13050"/>
    <dbReference type="HOGENOM" id="CLU_980201_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="284" mass="31921" checksum="0DA1DCB2BABF10D9" modified="2013-09-18" version="1">MDENHPPPGESSQGVEILATPKKQHAEAEFGDGNQSLPIDLVDDSVPSPNQTQAPPVRRGRGRPRGSKNKKTIAAENAARQPQTRFPSPPHALGDERDSHQSWMGDKYIPNNYGGSPRQAIDTSQLSNGEVLVPPDPSESHAIAELIKSYRNSVNLMKEKNRQSATISKDRLKEEEQYELAKLIDSHTWNQAQEDELDASWESGLVKAVIERLPDRGAYLSSVFETSYRLCNMDPLSLLSMYHNFEFDNSGSDSFMHAGQMKRNPLWTPHFCDKFKRIMAHPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0B9</accession>
    <name>S0E0B9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430140.1">
        <property type="nucleotide sequence ID" value="XM_023576998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0B9"/>
    <dbReference type="GeneID" id="35400293"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06816"/>
    <dbReference type="HOGENOM" id="CLU_2469255_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="88" mass="10381" checksum="9F931F1716F7FA9B" modified="2013-09-18" version="1">MSRQATKQLGATRTNDNTSRRTLCREARVQQQYLQRLSLGVQTLKLQRDRDPVVQALTKRNECLEKEIQYLHTQAMVMARKMFEKDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E169</accession>
    <name>S0E169_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable delta3,5-delta2,4-dienoyl-CoA isomerase (Ech1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_07371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430659.1">
        <property type="nucleotide sequence ID" value="XM_023577615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E169"/>
    <dbReference type="STRING" id="1279085.S0E169"/>
    <dbReference type="GeneID" id="35400848"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07371"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_1"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT68579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="285" mass="30541" checksum="A15EDEE180212EEE" modified="2013-09-18" version="1">MSSTTPLPAYTSYKNIIVSSPNPFVAHVEINRPQKLNAFTQELWLEFGRVFKQLSGDEDVRAVVVSGAGERAFTAGLDVQSASNDGILSGSQADIAKKAKVVRNHIEEFQDSIGAMEKCEKPVICVLHGVSIGLAIDIACCADIRICASNTRFAVKEVDIGMAADIGTLARLPKLVGSTSWVKDVCLTARDFSAQEALSVGFVSQVHEGKQAAVQAAVALATTLADKSPVAVQGTKELLNHGRDHNVAESLRYTQVWNAAAVQGKDFSLALMSGLKKTKPRFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1X6</accession>
    <name>S0E1X6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_07514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430785.1">
        <property type="nucleotide sequence ID" value="XM_023577775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1X6"/>
    <dbReference type="STRING" id="1279085.S0E1X6"/>
    <dbReference type="GeneID" id="35400991"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07514"/>
    <dbReference type="HOGENOM" id="CLU_397417_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF40">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495467" description="Glycosyltransferase family 31 protein" evidence="8">
        <location>
            <begin position="36"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT68705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="85461" checksum="8A7E633A837EEF14" modified="2013-09-18" version="1">MGLHLSSAWSTPRGWRLITVTLVALTLLLVVPLHRLSDDSPGVYGHLTNYLSHEGAAYDVEEGFVANLNETTTNQILNDKEPAEKNPYDTDSPQYTGEKDKEASASAEKPAGAQHPEDDKKAEDAEDDGAVLEIDHGDSDTPQSTDQIHSEVPKETTKPESSETELQAVQSGEPKSQEDGNKPEEADKEHRPQDNTQPQTGEKKLQADEKASGDEHKPTHSEIKTEESENKHQQGDDKAEDKDKGDKQPDGTKLSDQSQNNNDHKNEDGDSAAKTQVYQDSATTSIASEFMPSQTADLDVPSGPLSNWTGVCDGFPNTDGIMLVMKTGATEAFTKLPAHLLTSLQCLDDYLLFSDLDQQIDKYQIYDVLKDVKDDVKKGRKEFDLYKAQTECPIAQQYCTENMKEGWNLDKYKFLHMVEKAWEMRPNKEWYVFAEADTYVFWSNLVWYLRNRVNGTETPYVGSVAMLKGKPFAHGGSGYVIHGDTMRKMVEIPDLAHKYDMMATHECCGDYLMSLAVMETGKKVKQAHPMFNGEKPMTLPFGNNHWCEPLLSMHHMNPEEVSDAWHFEKTRQKKGFIQIREMYHQFWAPQLEAEHDEWDNLSDDVCYIGFGPEAQGKATDHQKGRQKKENEKNAIEQHAHRSKEHCAMVCEAENLDISEDDYYNLKDDKERNEMIRSRYSQKKGSKEWHAGRRCFQWRYHNNVCCIARSFKRGKPRKEQKPEEKWTSGWFVQGINDWIDAKGDCTPKWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E239</accession>
    <name>S0E239_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429803.1">
        <property type="nucleotide sequence ID" value="XM_023576685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E239"/>
    <dbReference type="GeneID" id="35408099"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14719"/>
    <dbReference type="HOGENOM" id="CLU_108575_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485203" evidence="1">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="206" mass="22847" checksum="FD11243402A405CE" modified="2013-09-18" version="1">MQTFNILFITLATAVAGVTSSSSCPPFPASMTPFSYGFKEPKPPAIKPEYQAHFVQHKWNGELSHITAGFIQNSPSKGFVRADEAFDGVLASSTFDYSNVTKSGLVDNTLTTYDPKKSKPSIWRGYVNSNYPILNKTVLIDNGAVFEGFVKRDFTPNPVAAWSIMYQNAVPVTVFVNECGVIVGYDYFAPELRTRVIMEFFNIQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2I3</accession>
    <name>S0E2I3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429953.1">
        <property type="nucleotide sequence ID" value="XM_023576629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2I3"/>
    <dbReference type="GeneID" id="35408049"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14669"/>
    <dbReference type="HOGENOM" id="CLU_082466_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495451" evidence="1">
        <location>
            <begin position="26"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="294" mass="33118" checksum="FA7C38FC0D515CD8" modified="2013-09-18" version="1">MAPVFGTFYLSLLFILLLFSQFLDAIDLSVKHPPPGHLKVRLDYGLATQPIPGVTESRRRESQHRYLFSSYLVFNEPVASITDGQLRQMAQVAHGEMEKDMQQYKPTVFADKGQTKPTYLPSVMTIVAFGNEIILSSSQKGLDGFLNQWPQSPVKLALDRCSALWRDRVVNDPESIADPAAGHKNKAKCGEVNAFHQYYMTHTTSIPEVKPKVRVTTVVKGRQGYTILPPCGTDDNGEDEKEFWGCNLLVRDQDVHYIGQEEKAMPFSLRKIAGGVKKKGQIQMCTRNNIIWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3Z3</accession>
    <name>S0E3Z3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431546.1">
        <property type="nucleotide sequence ID" value="XM_023578554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3Z3"/>
    <dbReference type="STRING" id="1279085.S0E3Z3"/>
    <dbReference type="MEROPS" id="M19.013"/>
    <dbReference type="GeneID" id="35398832"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05353"/>
    <dbReference type="HOGENOM" id="CLU_031404_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="392" mass="43226" checksum="2EFB04786324CA9A" modified="2013-09-18" version="1">MAPISDEYLSQAHALLKRVPLVDGHNDFPYMIRGWFGNNFELFHPGIHNMPIGQTDLTRLRKGLIGGQFWSAFIPIPKTNDTLGKLECLMKTLQQIDTIHLMIENFSDHFGAVNSSKDIETIFKSGRIASLIGVEGLHQIADSASVLRLFHKLGVRYITLCHDDDNRYADSSNGKSTNGGLSSYGLDMIREMNRIGMIVDLSHTTTETQKQVLSVSEAPVIFSHSSCNSLLPSPRNVTDEILDLLKTNNGLIMICFLPDLVSANGVQGAMIDQVIDHIIYAGRRIGFEHVGIGSDFDGMLEGPKDLDDVSKYPKLVEKLFERGLSEDVVAQTLGGNVIRVLGEVEAVSRELKGHVPVLSDPIEEVWTSEQKDILTRMGTLRSSRGSGTNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E484</accession>
    <name>S0E484_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430572.1">
        <property type="nucleotide sequence ID" value="XM_023577513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E484"/>
    <dbReference type="STRING" id="1279085.S0E484"/>
    <dbReference type="GeneID" id="35400756"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07279"/>
    <dbReference type="HOGENOM" id="CLU_741934_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="349" mass="38283" checksum="22834486DC118FCA" modified="2013-09-18" version="1">MNRPSSMDLSQPSSNNHFHVVGGNGYPVQVSYGGWQQNTQVSQLSAPRGMTSGNWRGSQPSANPMNSAVPGTKHSLMSSPTHPSPSNNEGGPVSISDCLNGYAYCVKRPDGLYTRLIPADMVPTLIELPATQTSAQGMVLLPDLHMQPPQGVPGMNQPVTFKAPTGPASDILQTRIDRIVATSPTQQRRTKIYCDKWIHDGTCAFTQQGCKYKHEMPFDKATQQSLGLFHGFPKWWRDHQEELQKHRNRDLPASNNQAILQSGWRGDGNEDVPQTATVLAPIGPERNQKSSKKNRISQTCEGLLAAPAPEKRSLTGSETEWFMASPAVQNWNGSSPRRSSVSAGRYIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4Q9</accession>
    <name>S0E4Q9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to WHI3 protein, involved in regulation of cell size</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_05789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431949.1">
        <property type="nucleotide sequence ID" value="XM_023579041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4Q9"/>
    <dbReference type="STRING" id="1279085.S0E4Q9"/>
    <dbReference type="GeneID" id="35399268"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05789"/>
    <dbReference type="HOGENOM" id="CLU_017278_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12245">
        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000089">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="358"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="546" mass="57833" checksum="691D06DD1D88C7A7" modified="2013-09-18" version="1">MNIDQSAPPSDPARIASPTANLSYRASPLPPPAATSAKPSAATAALSNTTSTVASAASLSAMATPSFMNPSLRSMAPPYSHPQISRDFHRYTPAPIGSSSSPVKVLIRNLPLETSRESVRFMLVWSQDLVDVELLPVDSAEPHYLTALLKFRTRAGAEDAKQLLDGCANTSNSALLRVEIISDEPSVAHQQPAEPAHNGVFQSMENISPQTTNVYPGHDLPKNEGKLQQIFSPHSPIGNHLNEPGRATGKSLIANDPYDDSYDPLNFVEDALSYDNGPRRATVPSVPINGMSSLSLNTNMPPSAPSSLPQYGSGMSAQSGPMSPSGKGQFGYQAPNQSPYGRMNYPHANTADQNPPCNTLYVGNLPMDTAEEELKTLFSKQRGYKRLCFRTKGNGPMCFVEFEDIPFASKALTELYGKLLSNSNKGGIRLSFSKNPLGVRAGQNPAHANPGALGQMNGNLAASMNAFGSANRSAPLPPPGLPQPMPGNGRGPFHGGASMNPSSTGTFGGFTHQAWPVAAFNNHVTPSPHSAHAQSSGFSSAYMLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E506</accession>
    <name>S0E506_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to glucuronyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431926.1">
        <property type="nucleotide sequence ID" value="XM_023579014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E506"/>
    <dbReference type="GeneID" id="35399244"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05765"/>
    <dbReference type="HOGENOM" id="CLU_027158_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000048">
        <property type="entry name" value="Unsaturated chondroitin disaccharide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="493" mass="54766" checksum="12E2E2869264F56D" modified="2013-09-18" version="1">MTISNGINGHANGHTNGHTNGNETTTKNGVLFAKPYKASISSIVSELFEDNITAKILHAAESGLVNNNPPLAYPEYVPQTGSDAGKYILREKLFWTCGFFPGSIYSLIERLIKYPQASAGDTNKQQLLKQLLDVGRAWSDPLHEYAQRTDTHDMSFMIQPSMRVRWETLHDSTALESIITAARSLYSRYNANVGALRSWDVLSQNGVDISSMTEDFLVIIDSMCNLDLLYYAAAQTGQTEMAEAATAHAKALIKALLRKETDESVGRTMYSTFHVVNFDPRDGSVKEKRTGQGYAANSTWARGQAWGILGYSQTYNWTKDPEFLDAAIGLAEYFIFRLLKSPDCVEVPVPGESRTKGRYVPLWDFDAPIDTSAPLRDSSAGIIAANGMLVLSQALAGSGSPDLSERYRSMAIRIVKDTLDFSLSQEKSKVALRSDGKFEVQDLKPEAHFEAILKNATANHNAKDYKRYWDHGLVYADYYLIEFGNRLLKMGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E578</accession>
    <name>S0E578_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431930.1">
        <property type="nucleotide sequence ID" value="XM_023579019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E578"/>
    <dbReference type="STRING" id="1279085.S0E578"/>
    <dbReference type="GeneID" id="35399248"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05769"/>
    <dbReference type="HOGENOM" id="CLU_041303_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484873" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54377" checksum="24134B5EE5282550" modified="2013-09-18" version="1">MKSILFLVASIAFTSTFAASVHTADIDDLKGATDTFNAALRESQYNLTEADGDVGDFATRLFGFEGCGYWGSLKRKAIYSGWQQAWHMMDAIQGKELNWNEAAAVEFFAPPFINEEEQSAIKSTISPLLSSLAGSSLNPFQWRLHVRCDDPSDICKCKPHTQLAYTTNKDQESGKARIAFCPNYFLEPDLLKVIDGNSKKELPIEHRADLNNYVRNKGRVWFHELLHVDWASGVDPRYNIADLHALYVRGDQTIVKQKIYNPAKTKGLATFPLDPACWIKRSADNFAMYAMAKTVQKITGNYPHLPFASTLESMVGTEGQGKCQASEDEHGPGDKGLVVPKTSSAWFSGQDRYPEDYNRQLRGWLADANPRHNRVRIVLMQTLMGSQWIAIQDTPEEPVKDFCLAKVLSKVPAKADEDNPEFPTELPAFEAHGAKGCIYSGTSNIVGNLTCENGPLDIRCWEDPEWREMSYCDGGKYMLGIKCDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5K9</accession>
    <name>S0E5K9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432110.1">
        <property type="nucleotide sequence ID" value="XM_023579237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5K9"/>
    <dbReference type="STRING" id="1279085.S0E5K9"/>
    <dbReference type="GeneID" id="35399443"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05965"/>
    <dbReference type="HOGENOM" id="CLU_019833_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT70031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="727" mass="82018" checksum="ED7E1589894AAD0C" modified="2013-09-18" version="1">MSKRYRQLLPIPPNENSPPNSHPSGSSSTPRSSSDEPLKRQRIGTQLACDSCRKRKIRCDGRKPMCEACRRRGEKEPCTYAETRSPGQTSKKTEQILGLFDILKTVPESQAIDVLRVVRSHADLDTAVSIIQPRITKNISDHERSPEHPRHLGLEAELMAGHSLAFPALQPLESSILKKVFSASRTSSSAQTDKNTPITNSDPNPFPAHDPTQSLAPTLSSCDKRLEELNIGFWTSVPIASDLAAKVISLYLETDHPLLGPFDPTLFMEDLVHCRTKHCSKLLASTIMYWSCQMYSAVDSTVQPFIPQFCEEAEKRWSLEKATDSLLNLAATQLLGLAYLGNGKDHYVLTYVSEVNAMGARMGLFGVEQSVANSKAKQVSPELQSATSYAAWGAFNWIVLMALFYQQPGLSYPEHPPIVPIPGHEWNDPSDSSPGSHQQRPKQAYMGGTFPIICRFWRIMHEVTLKYYRDQPLPRESLNSHITLAFAEYKYRELIAWAETLPPPMVRSEQSPHHVFVFHIWLHVAILCVLRPFTVRARDSPKPLRLKTFPCRRSSPDAACKASVNQLKRLVVMYREKYACSSYTMLWHTALIHIANAILGDTKDPAWRFYLFFCVESYGELRRAFRFAETIGRSILSMALQQGDLSTDEARRLMVQFEENRLTSPSEDIRATFMADLNLAMTDPEEASVESLSGRFEDIALFREFTNAGDSSEDEPVESDDNTWDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6R3</accession>
    <name>S0E6R3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_06534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432633.1">
        <property type="nucleotide sequence ID" value="XM_023579869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6R3"/>
    <dbReference type="STRING" id="1279085.S0E6R3"/>
    <dbReference type="GeneID" id="35400011"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06534"/>
    <dbReference type="HOGENOM" id="CLU_019706_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495594" evidence="2">
        <location>
            <begin position="23"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="91"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="4">
        <location>
            <begin position="422"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT70554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="611" mass="66229" checksum="15AAECF59551F8B9" modified="2013-09-18" version="1">MPSLSKIAAVAAVSFTLIDAKACPPLGAVFPAPQSPSQSSIAKKATSLLKAGLDAQIGAQFNNSALSIGVKSLHEDDPLFTYQWTPPNPGEGTDKVDEDTVFRIASGSKLFTALAARISDKIDLEASVLKYLPELNKTAGDDDIFSLKWEDITVGSLASHLSGVGVDMAQDLAIVGSAPWQPYGLPEVLKSKGPNCSGLPGTTPCTRKDLLEQVNLRPPVYAPFTNPIYSNVGHALLGLVIEAAEDMPYEDVIKRDILDIVGMKHTYVDKTPPTDELFIPVEEPTWNATLAVFDSAGGIFSSVSDMLLLADGILSNKFLTPVQTRKWMKPEANTASWGYQVGGPWEILRGDNITSDGRLIDIYTKSGDLGLYHSQTVLIPDYDIVISIMTGGLEASANPFITGTILSKVLQNLLPAIEKVGRDDTKEAFAGDYEDKETNSTITFAMDSGPGLKIKSWQVRGFDVLNNIGNYNFNALESNASTETPYVDARMYPSNLNKKGQTAWRAVFDRTNSTADAEYDTQLFFKDGACQTWFQQDRMVYDYLPLDLFVFVEGEEGVSEAVKSPAFNVTLTKVRQPAEKKAADDRNAAGEMRVGGLGLTLVAVATFISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6U5</accession>
    <name>S0E6U5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432605.1">
        <property type="nucleotide sequence ID" value="XM_023579837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6U5"/>
    <dbReference type="STRING" id="1279085.S0E6U5"/>
    <dbReference type="GeneID" id="35399982"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06505"/>
    <dbReference type="HOGENOM" id="CLU_1086600_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF15">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="1">
        <location>
            <begin position="48"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="215" mass="24037" checksum="3C1FC4D046E7B3CF" modified="2013-09-18" version="1">MATESSFHGWLDEKDWPNVDLDSNGNWKSSYKYSLASHDVEPVEGAFEFREPNLSPRFDWNHDPNKDKWTTGPDGLVLHTATITEDFSPAQNTLTHRILGPRSNVTIELDYSSMVDEDRAGLVSLRYDVGWIGIAKDGSSTTLQMVDNAEMGPENNSSPHQKERTDGKTFVKLGQEHVAKQGGVWFTGTRYSIFNFATKKSGGHAVVKAFDIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7H3</accession>
    <name>S0E7H3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432933.1">
        <property type="nucleotide sequence ID" value="XM_023580097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7H3"/>
    <dbReference type="STRING" id="1279085.S0E7H3"/>
    <dbReference type="GeneID" id="35402600"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09126"/>
    <dbReference type="HOGENOM" id="CLU_284000_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1095" mass="125056" checksum="61FC28A17D79B540" modified="2013-09-18" version="1">MNLENVGETASNQGPELRMKLEDDPRMTEGAEEPSVYTALGSWTRLSLENQYVYKFEMEASQGDYVRKSVLGGFHPYAPLQPYGTEDSAHDAYYVKVPNGFLRSNFNDAFVEFSIEWPKTKQVKGDIYVSLRYLQALAENNVAWNPIHVLDLVTKKDELCKRDERIQKKEEEWLNNSEKRGKKAADAAKAAKDKMDELIQKRKNVLIPPITARVKVKAVTPGFDFSERCGKAPNPVNDVTEEQRIYGVAGDTEEKALGPCLEEMHKMSSCKWKFRGKDDKEIEEHVEECQTFRIFVKAVIPFRAESGRLCFGCYSPFPAGTKNDIRKHYDDNRSALLSIHYYDYASMQWLWKEYWKSPTAHDQPKSAKSRGWRTRYDASPLSKPLVIWILPGARTRFYNTLNNGLVEGYKKSDPAGHAHEVFGKIIAQINEREKNDASRKHTKLQLAPEKWEWESSRHYCLLSEDPFRLYQTYIHKDCIHEYMQRFKDAADEADGREAEAVSPKADGAMNLETSGTQQATPVTNKERKDFMPIRQLPIGLDHKYIDKMSEYEAKQESFTEYWPTDPKITPVKKSDDQDEDESEAEYYESDEEESNPPAQGEQIVATKTPTQEVDEEDTKPIETKSKSTKEMEKKAEKAEPKKGMTRSIHVNPINAQKVIRAAGSRKGQKDQKAVMGFSASYFADQVLGWSWRPGPKATLKDRQMSNGLYIAEWLHLSAYSWGGIQQGTNTSAQKSSQTKKNLVFGTSEANSCMTRYEKAWQQLFKDEKLLRDKLADEQAKASTTSTTSTTSTTSTTSKTSKKSKKSKKSMVTEIEKYGKGNDKRTYLQGELSVVCNTKSGPYLFDEIDTETEKYVWKKRNPIEEDSTLAKLAEEFPFLAYNIRYEIRLMGQSRILAPLGESDSDVAGTEYELPTILHMKAMFYPFSRRFYHRSEHLLDSALYQHMFMLGALNRFDGDRALAEKVFEGRFKTKKLNDYKSWKKLSKADEEAAGKGKALRELETLKKKPLTKETALDLQDAQVRHQQAVKAKVRNMKSYTSKAGSIVKWPMGKKAEKYIGQMSFVPKNETYVSESQGEAHPDNFKKVPGQPGSSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7M5</accession>
    <name>S0E7M5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylenetetrahydrofolate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="2">1.5.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_06644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432734.1">
        <property type="nucleotide sequence ID" value="XM_023579992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7M5"/>
    <dbReference type="STRING" id="1279085.S0E7M5"/>
    <dbReference type="GeneID" id="35400121"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06644"/>
    <dbReference type="HOGENOM" id="CLU_034045_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="9">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="10">
        <location>
            <begin position="145"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT70655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="310" mass="34616" checksum="5D5BE7D7AF964E32" modified="2013-09-18" version="1">MEAIELLTLPLAYQNGSARLLTGDLVVRDIEHWCHRKAHRGGIEPVMAVVFFNTGPDAVDYVKIKAHVAARAGVDYWVYEMPADTSTIEVMNQVKKLNMNPQIHGILIQRPLPQQLNEAKIMGYIDPVKNIEEYDNGQADNIAADALVRLLTRYGLLESAQQAKIQIIGFGNIITKDFIKQMKRQFPYVSASKDFDPSHDTSRDKQEAEEEVQAPRASMIISELHRGPGFIKESMVKPEVSVLVDLGFYVTEKGVIGDVSHALFDRSDLAIAPTPGGVLPILLWIMMERTIKAKQMIAKEDLRGCCCSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7N5</accession>
    <name>S0E7N5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to tryptophan 2,3 dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_09096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432960.1">
        <property type="nucleotide sequence ID" value="XM_023580131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7N5"/>
    <dbReference type="STRING" id="1279085.S0E7N5"/>
    <dbReference type="GeneID" id="35402570"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09096"/>
    <dbReference type="HOGENOM" id="CLU_033932_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT70881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="495" mass="55360" checksum="1919AE69EC0A7E17" modified="2013-09-18" version="1">MSAANTLFPYLRKDPSELPEGEDPFTITTRTGYLPFSLPLKKLPSQFDPVSNLLNDIPILKEDGTPGLLATFALGPLIDSGALPDLTSEIDNLVVPGTDKRDMAAITAAFRDYSFIASSYLLEPCWETYSKSDDGGYGLGRQTLPKCIAGPLVKCAEILDIPAFMSYAASYALYNYWLVHPEQGHDDYDNIRLVRAFEKGLDPKSSEAGFILTHIHMVAQTGGLIEGAVDLLAAVEKDNSTAKIAEAKASLELILNAMQIIETNMEGMWSQSLPKDYMTYRTFIYGITKQSMFPDGVVYEGQYDDKPQFFRGESGANDAIIPLLDHICEIPMPKNPLTDILIEFREYRPKPHRAFLKYVRETASEVGVRDFLTKSGDHGLAVLYLRVLDHIRSFRWRHWMFTREYIIKHTLHPTATGGSPIITWLPNQLTAVMDLMEEVAKGSGLWAVLEEGVWSGGGSLTHEDYILVKKIMDNVVTKKAQLKKEVDKYCQDRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8E6</accession>
    <name>S0E8E6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to zinc-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432994.1">
        <property type="nucleotide sequence ID" value="XM_023580171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8E6"/>
    <dbReference type="STRING" id="1279085.S0E8E6"/>
    <dbReference type="GeneID" id="35402533"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09059"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="38"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="371" mass="39891" checksum="A883AC03E3051E97" modified="2013-09-18" version="1">MPHTVGCFALTHHILLNYLPQINMSLPETYRAFRRTTGDFPRTVEPSIETVPRVLGPNDVLIKVHAVSLNFRDVAMLNGIYPMTMEDRGIPCSDAAAEVVAAGSAVEGFVTGDHVSVISDLNNITGSEDEPLYGLGGDTAGVLREYAVYQDKHLVKLPRHLSWEEAATITIAGVTAWTALDGLTTASKSRSALMQGTGGVSMFALLICLAAGIQPIITSSSDEKLEAVKKLDPRVRGINYKTTQDQGAEVRRLTDGQGVDFVINNAGPGSVPQDISFLRQRGGTVSLVGFLGGIGGDWQPAAIMALMAKSAKIKGIAVGSKEDYINLNRFLEEKKVSLSPLVDRVFSFEESPAAFEYLYSGKHAGKVIIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8L5</accession>
    <name>S0E8L5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT71219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433298.1">
        <property type="nucleotide sequence ID" value="XM_023580537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8L5"/>
    <dbReference type="GeneID" id="35402204"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08728"/>
    <dbReference type="HOGENOM" id="CLU_2346852_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="97" mass="10651" checksum="1450F2880904BB8C" modified="2013-09-18" version="1">MDHQEVSRRNGAAKRPNTNLKVGASSSGLVDQADPLCEHSSVHNCANLTRHGCGSHVLGRNIGRVDWRIGKHNAGGVRLMGFRHVQLRCHYSRTKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8V9</accession>
    <name>S0E8V9_GIBF5</name>
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        <submittedName>
            <fullName evidence="1">Related to sedlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8V9"/>
    <dbReference type="STRING" id="1279085.S0E8V9"/>
    <dbReference type="GeneID" id="35402101"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08625"/>
    <dbReference type="HOGENOM" id="CLU_085828_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="162" mass="18378" checksum="1E78780B5448C40A" modified="2013-09-18" version="1">MSYYFAIVGTQDNPLFEHEFGTSKQGGDGQSRFSDQVRHLNQFILHSSLDIAEEVQWSHGQMYLKCIDKFFNNYISCFVTAGNVKFLLLHQPIIPTGTSSRSSTAIGANPTSPATEEAIKMFFTEVYENWVKAIMSPFYRANMEVRSPVFRTRVAAAGRKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9M8</accession>
    <name>S0E9M8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432546.1">
        <property type="nucleotide sequence ID" value="XM_023579768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9M8"/>
    <dbReference type="STRING" id="1279085.S0E9M8"/>
    <dbReference type="GeneID" id="35399920"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06443"/>
    <dbReference type="HOGENOM" id="CLU_1970739_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="127" mass="14190" checksum="0596856AD210A7BB" modified="2013-09-18" version="1">MITADEKRAMVTQYNAFVIASSPVPGIGAYDVEITSNHKYSFLLLCQPDWTSIIDHIKLPEDQQCTWPTRRRYTEADMEALVTPNSALGGNTAMEDAVVIANTLHTLLAKHPNKKPSDVELHDAMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9V0</accession>
    <name>S0E9V0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to NEUROFIBROMIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433509.1">
        <property type="nucleotide sequence ID" value="XM_023580796.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E9V0"/>
    <dbReference type="GeneID" id="35401973"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08497"/>
    <dbReference type="HOGENOM" id="CLU_000249_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05392">
        <property type="entry name" value="RasGAP_Neurofibromin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054071">
        <property type="entry name" value="PH_NF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21877">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2448" mass="273374" checksum="A979BE2E6DA18BC0" modified="2013-09-18" version="1">MNCDASLVGCLVDRLATRLPHRAGTTGQSLQQDDVLHVTRATLVELGNTSISTVIASLLVLLEDLARPYAAVADHPSHILASELYIVAVIADCCSSHWASLSQDADVEPTLAPPSLDEVLVSRLFDAFKHLLEPIPENCILPAQTLLDQVSTRNVSVTRPESSSVSSDADSSPPSDERFADTLVEMDIHIKTVTEYVTTSSWTAAFDYLRNVIYTIRTSIATQPGVSAPGSTQDAERAALVVLRLLSFFWVDGPKLGQVIQEICSSFLHFRKPYQNTIAVVSPLLIMRWLGRFPREFVQLHQLHKRLDGGADTLFDMAQAATDNGRRKGLFYPLQTTLLFLLPDVFEVASNMREAKSSSMVKKVTFLDGLRKASRNRNEQAAYCLVSLLRAARHFDVESDSALVSYALDVQDEVRDAVFRRLTASEYGLFDQDMMTAAFVSLTHLNLDTSVSGFVESCIASNAPSSFKLATVQGCTYFAQQPYALRYHELFDAAIPFMRTQLETENAKAVNTTGRQGSERTELVCSILQFLDASPARLLDDLSKDGSNNSFFKSFLLCVLSENPAVRKLATGVASRLFQGHLEAYRQFDTGHRFGTKELRDDIWSRSSKVLLALCESVTSKKDDQSLRDLQDYLEARFLLLKNIPELAKVPEDAPDVINASSKLETTLLISLCSASITTCQLVTSCTGLFIQECSIVDKHVESAKTSASVLRNAEVYREISSPAFRFTGLVAFQKRVRGFLRRMQFPTTGIVNAWETAFDRWLHLAKDVSTSTVEIVDGRALAEWRNYSGFLASLGGICTADQAIILEEPALGGLRWIDRVSSEHSEEPLLTRYLRLSIQLLACANVRVREAMRDVLASEVSPTLYYPLFRALESELEVLFTGALAPVEKDQDSEVVFAEQAASLLRALVERLESPSDLGAASSVHLGALTLNFAKFLDGVTDTPNTLRVKIRVCHLCEVVTKRKEHLNLRDDVRIRNQLLEYIFGWIARPRSPQHGPGSRQDDTARVQKDLDKACLKSLADLTFRLPLQPSESHTDAGMSEMKSQMFHTYFNRFLSLLNHEPSELTRTDTNLSVTLREESASNSDLAITILSNLLSANIDVGLKHSLNIGYHDNVEIRTAFVKVLYNILIQGTEFSNLTDSAVSEKYEELLELLTNDLSLAISMAVACPSTEVDELTICLLTVFEQRGMIFELLEALIKQEIEDTENEAEILRRGCVATKMLSVYAKWKGASYIRTTLQKVLERLMLTSKDLDLELDPARVSSTEELQKNALQLRIVAKVFIDDICASSSNIPPAFRKICYTISNAVMPRFPDAKYTAVGAFIFLRFFCPAIVAPEVEGLVSAAPSKEMRRGLLLIAKVIQNLANNVLFGAKEPYMFPLNDFLTQNIYHVTTFLREISVPPNQMEVQGTTESFDFGSCVALHRFLYDHWDHVRQTLISRERKDHGRTSGDVVRGRSPVLEPLRNLIANLGPPPLAVSWNRPQVSSNSPPLYSRFQNFMLRNAFRSTESFLTARAVYDGGESKDGLSIICVILRHIETESIDYDTLMYCYLKIASRLWHRPFGILIDATCYNGRNEPQDDLFKKLELLTPSELSQNLSRIYVYNMNSAFKRCFRRLLRVCTKNENGVFNPKNVEYHLIGSLQDLQAHFHLSQLHLPKETISVVTDTRYVFQPITRLSKSKGKIEVIIKVGSQFVQVTTTKKQEIFAGFRLGTTVNDIFRLGEVDEAPTSIQTEDDSAFGLRADNGKIVMYFTSPKKSDVLQTIRGAKAKHGKDNRAHKSVERLIRPQDVPGTLLNLSLANLSSHDHILRLSSYNLLGALCRAFKFSSASRIVCTKDVSVPLDPTRFVVDISKELALSEPQLTSDFLTEFFVGWESFPDEQKPLSLAYMAPWLPGLRTNILTNELDGEKGRERVAILFRKLIDVTVQDHSLTFALEQSVWPRIIQDEILLEVFLDELLKSAMSYSAHDESLEIIASIVVGIGTVTLRGKILSRLRKALNRSSLRPTKYLPDNAVWSEICVLLRFCLALSFDNGVQSQLFLPEIFHIVTMLANTGTQEVRLLVYRLLVNTVHAVCTSFSLDDTRSSKLRASLDFLCDPRSDIFTAPPTFPRDGASVSTSQDAGPALTATENLASALFEICSVAAPTVDLANTWRSRWMSLVASTAFQNNPAIQPRAFAVMGCLAREEVDDDLLYQVLVALRNSVNRFGEDHNSEMLVSIVTSLSKMMAKLPSASRYGLQLFWLAMSLVRLVPATLFNCTAQFLEAVLANISTSEEFRGDSMASLLLQGRAPLDEAALPLEEMYGIHFEEETFHLAVCACLARGLTDTMTRQITMRVLSSFLEMMTANVEGREKAEMTQTSAYLSLMTARAVENDEFKDSLWSAGINADELGFADGMRKSPDLEGMPDNVVLLITAIELVDFQYVEDSVQRRSLDWLNKLASERPIVVDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA07</accession>
    <name>S0EA07_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433554.1">
        <property type="nucleotide sequence ID" value="XM_023580853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA07"/>
    <dbReference type="STRING" id="1279085.S0EA07"/>
    <dbReference type="GeneID" id="35401922"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08446"/>
    <dbReference type="HOGENOM" id="CLU_041686_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="382" mass="42016" checksum="A9C4AD59A9AAB75E" modified="2013-09-18" version="1">MPPKKSLRRRPATPNLNVAQLRAQVQEVQNQPLTADPNSPPETPTTSPPFLRKTSLKPRRQPDFHDYFQSLDSDPNIKPTGDGHQFSYQPSVGPHQLSPRSSSSSGMADDTSDEDSSSEDEDEEGSASPSIRSMGNATGPAVSSPIDDSAMELGDDDTDSSSDSDTSESDSGSESDRSGATDEAETSHITVTSTATATVACNFTVEDIDPMDSDCDGLDVLQPTEIESNRSRSRSRSRKAHKTMVKDFRNLTCSNETSDNEQSPEGEGELDEEAQFLKRREQIKKFRRMSMGSSFGKRTHSELSDSEDEGEGLDANEVGSSARRMRRKMHRTSLLFHDPPPARIEELEEPDSSEDELVAHQHLARELPYWAIEIMEMGSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAJ9</accession>
    <name>S0EAJ9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_08242</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433744.1">
        <property type="nucleotide sequence ID" value="XM_023581079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAJ9"/>
    <dbReference type="STRING" id="1279085.S0EAJ9"/>
    <dbReference type="GeneID" id="35401718"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08242"/>
    <dbReference type="HOGENOM" id="CLU_016733_0_1_1"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT71665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="434" mass="47167" checksum="DCB9FE28EF83AD98" modified="2013-09-18" version="1">MASFMRMKAATGLSGLSRVAISRASLTHSAILCQRDPQRRLFSNSSIFNGSYIVSVPPMAESITEGTLASLPKKIGEAVEQDEEIASIETDKIDVLVNASEPGAIAEYFAEEGDTVVVGQDLARIVTGEDAGSAKKSEGEESKPKEEPKKEESKPAEQPKPEEKQAAPAEAPKASKPAESKPAPKESKPSPPVQGSSSGPSRGERVEKMTRMRKTIAARLKQSQNTCASLTTIQEVDMTNIIAWRAKYKEEVAEEHGVRLGYMGAFTKATTLAAQKVPQINAMIDTEKEIITYRDYVDVSIAVSAPKGLVTPVLRNTHELSIVELEREVASAAKKARDGKLTMEDMEGGSFSISNPGIFGSMFGTPVINYPQAAVFNMNGIRQEVVAIKGEAVIRPMMYISLTYDHRLIDGREAVTFLNTVKKYIEDPSRMLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAR2</accession>
    <name>S0EAR2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to beta transducin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434052.1">
        <property type="nucleotide sequence ID" value="XM_023581341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAR2"/>
    <dbReference type="STRING" id="1279085.S0EAR2"/>
    <dbReference type="GeneID" id="35407486"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14032"/>
    <dbReference type="HOGENOM" id="CLU_000288_138_17_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="537" mass="60480" checksum="17E1076F897DB8D4" modified="2013-09-18" version="1">MRLLTVANDGELRLADFVGDYIPPYTILSHTWGKDSEEVTFQDMVEGKGKNKLGYQKLRFCEKQSANDNIQFFWIDTCCIDKTSSAELSEAINSMYHWYRDADKCYVYLSDVSINGSVGSSLFPHQTWETAFRQSRWFTRGWTLQELVAPSCVEFYSLEGERLGDRESMIQEIEDITGINTEALQGSPLSRFGFEERMSWARGRETKREEDAAYSLLGVFGVHMPLVYGEGRRNAFIRLQRVIQESARNFGSEGFHFILQRGTALHETDERFRFLMGDMNRDGCPDLVAVKSRDTTSSMIELSVFSGASLFRTYISETVIGVPVTTTTQYDFALADWDGDKTLDLVVIKKGSTDTKTTEVCILSGASNFQDIILHTGTALHETDDTWAFSMGRWNAGRKPDLFAIKKSSTGTNSTEVHVLSGASGFQKFILQTGTCLHETDDAFDFAVADWNADGCPDLVVVWKSNDSNRYSLLHVLSGASTYQDFMLHAEIPLLDTLGMYEFMVTEWTRNGRLDLVGIRKSETGTNSTEVHIMTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB23</accession>
    <name>S0EB23_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to high-affinity iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434194.1">
        <property type="nucleotide sequence ID" value="XM_023581505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB23"/>
    <dbReference type="STRING" id="1279085.S0EB23"/>
    <dbReference type="GeneID" id="35407338"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13884"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT72116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="332" mass="36263" checksum="6507E375E1329BA2" modified="2013-09-18" version="1">MLDLFSVPVFVVVFRETLETAIIVSVLLAFLKQTLDGSQRDAGIYKTLRTQVWLGTALGLALCLIGSGVIIGIFYILGNDTWADHEYYYEGVFSLISAVIITIMGGALLRVGKMEDKWRAKLAKAIETPVTAQGKRAWLVNLFEKYAMFVLPFITVLREGIEGIVFVAGVSFSAPASAVPLPVIMGLTLGGLVGYALYRGGSSAKLQYFLVASTCLLYLVAAGLFSRAIWLFEQQQWNKVVGGDAAELGDGPGSYDIDRSIWHVNCCNPQLNGGGGWAILNAVVGWNNSATYGSVLAYNLYWVFVIAQFSLMSFKEDHGHYPLLKEEGTRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB36</accession>
    <name>S0EB36_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433051.1">
        <property type="nucleotide sequence ID" value="XM_023580238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB36"/>
    <dbReference type="GeneID" id="35402473"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08999"/>
    <dbReference type="HOGENOM" id="CLU_121547_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="150" mass="16477" checksum="4F42476D2142D3DF" modified="2013-09-18" version="1">MPSNYEKLSRPSGETNLTIPEKAATNATVTETPRISTTSTPQTDKLNPFDTDIEAMVTTRTSDSCMHKTSSTPLARKTDCQVWPGKDHWKQQAKAAKAKNRCTCMAKLSQRNRWIVKGLIIFLVVGIAVGVGFGVSKPLNAPIWGDKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBE9</accession>
    <name>S0EBE9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_05674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431843.1">
        <property type="nucleotide sequence ID" value="XM_023578912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBE9"/>
    <dbReference type="STRING" id="1279085.S0EBE9"/>
    <dbReference type="GeneID" id="35399153"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05674"/>
    <dbReference type="HOGENOM" id="CLU_050460_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT69763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="336" mass="37346" checksum="F93D741EC01BF1D1" modified="2013-09-18" version="1">MADSTTEPQASAPVFKKRGAKGKANLRKRPATPPPADSDDSDYSSSEDESGQRVKRRKKTATVTASSKDLATGKTDLQATVYTADRNVPITSTNDATKHSNWYDEDSQDALSAKNLLGSTRIATKDSQPDGTYKGLANQTTFIQKNPDAPNRAKGPVKASSNVRTITVMDFKPDVCKDYKKTAWCGFGESCVFAHIRDDVKQGWQLDKEWEEVTKGKQNLGGTVVASANRDKKVENTDDADEIAMLEKIPFACIICEGPYREPIQTRCGHYFCEPCALKRYRRDPTCAACGAGTNGVFNSSKKLKKLLEKKKEREEQKKKKKKKKEEEEEEAQEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBX9</accession>
    <name>S0EBX9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434472.1">
        <property type="nucleotide sequence ID" value="XM_023581844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBX9"/>
    <dbReference type="STRING" id="1279085.S0EBX9"/>
    <dbReference type="GeneID" id="35405716"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12260"/>
    <dbReference type="HOGENOM" id="CLU_029214_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.80:FF:000001">
        <property type="entry name" value="Chromosome segregation protein (Pcs1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="3">
        <location>
            <begin position="360"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="467" mass="51166" checksum="7CE2267EB7E92DC6" modified="2013-09-18" version="1">MPPRARAKPATGLAGLVASDSEPDLDMFDQSELQAVVRTMSTTKKPRGRPPGTASKVIKTAPRTTRRNSADKLAYVPEVIAQPAATSKISDGATKRGRKTKQLAPDETVTFEDIGVPPSIPATETKRGLRGHPKKLNGEPSILAPESAVKRRGRPPRQPTTPIEEIPETQAEDVMELDAVPEEDEDRNSITGTAEPLESWSSYGTSDAALRRRLGELTKKYEALEMRHRDLREVGVREAERNFDRLKKQAEERTAAATQLISELKVELAAQTALAKEGEELRKQLEASEVKAENLEGNIETLNSSLSEAEAEIKTLSNKLAAVRSGNANTRVPGSAIKASGPANRTAQAEAAHAAQAIAQAKENLYADMTGLIMRGVKQEEIGDTFDCIQTGRNGTLHFKLTVDNDDTSDNIEDVQFTYQPQLDAGRDMELMEMLPDYLTEEIVFPRSQAPKFYLRVSKSLAEDLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC13</accession>
    <name>S0EC13_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to RNA processing factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433421.1">
        <property type="nucleotide sequence ID" value="XM_023580685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC13"/>
    <dbReference type="STRING" id="1279085.S0EC13"/>
    <dbReference type="GeneID" id="35402072"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08596"/>
    <dbReference type="HOGENOM" id="CLU_040063_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="181"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="415" mass="47816" checksum="8B2C72966E234F61" modified="2013-09-18" version="1">MGFTKPPVQALKSSNKLKRKELFVQYKKHQNKERHEERHRRRREEAKDPELKAARLAKRKPATIDSKRVWDDIDDDSLGVQVDLEKLKRRRIEEAEAAEQAAHEAAMRAEEELDEDDDVDSMLASDEEMDEERQAAMEKNRQRRAQRDNSVAPSTTSTNLDLTPTSLALKFPSLFTDIPAPEPKILVTTSINSTLHEQAHVLCEFFPNSSYVPRSAHRYGHKYSLREICKYASNREYTAIILLKEDSKKPTGLTVVHLPSGPTFHFSITNWIEGKKLPGHGNPTNHYPELLLNNFKTPLGLLTAKLFMTLFPPKPEFQGRQVTTLHNQRDYIFVRRHRYVFREKRQTEKSIVGADGKEVKGVEGIRAGLQELGPRFTLKLRRVDKGIGRAGSEGDDATQWEWKAKMEKDRKRFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECA1</accession>
    <name>S0ECA1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to Na+/H+-exchanging protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_12386</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434587.1">
        <property type="nucleotide sequence ID" value="XM_023581986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECA1"/>
    <dbReference type="STRING" id="1279085.S0ECA1"/>
    <dbReference type="GeneID" id="35405842"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12386"/>
    <dbReference type="HOGENOM" id="CLU_008635_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="32"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT72509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="536" mass="59259" checksum="BA44FEEFF3F7F032" modified="2013-09-18" version="1">MSGNLWSIPLQTTNFNIVVAFLGGFISVFGLVSYLLKENYYLSEALISLLAGVAFGPHGANFIRPKDYAECAEFPESCDFDLNAITLNFSRLVLGVQLVLAGVQLPSKYLVREWKSLSLLLGPGMTCMWLATSLLVWALAGQPPFLHALAIGACVTPTDPVLSAVIVKGKFADHNIPQDLQYLITAESGANDGLGYPFLFLALYLIKFTGAGATSGGAADAMGLWFGMTWGYTILLSVIYGAVVGWVGKELLHFAEKHNYVDRESFLVFAIALALFVLGTCGMVGTDDVLACFIAGNTFTWDDWFRLETKDDSLQPTIDMLLNVTIFLWYGAYIPWRDFHDNSVIPLWQLVVLGICVLVLRRLPWVFGMHKWIHQIEEVKQAIFVGFFGPIGVSAVFYLFISLEFIEKHLSNEDGRPRSDVKNLGDQTRIIVWFLAVCSIIVHGLSIPVGKLGFHAPRTLSRVVSESLSDAPAGGRRRNIPFIGRYFFGPDKKDARPPTGPIVITGAQRMRSELPVHAGDETPPIRREIQFADEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECK5</accession>
    <name>S0ECK5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_06049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432187.1">
        <property type="nucleotide sequence ID" value="XM_023579330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECK5"/>
    <dbReference type="STRING" id="1279085.S0ECK5"/>
    <dbReference type="GeneID" id="35399527"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06049"/>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="432" mass="47893" checksum="99A8E78CFE30A018" modified="2013-09-18" version="1">MVIPSVLIIGAGNFGAATALSLRRKGKVQVTIVDTAYFPNPRAASHDINKIVRDDYPDRLYMRLLKKAMPLWRHDELYKTWYHEVGMLRADSTSFGEESINSYRDMGIPNRSELLPVDEVRRRWNGAFETADFKGVDRVLWNPDVGFAEADKALGAVVQAAVDLGAEYVVGEVTKLDFGSEGQCIGATLKDGTTLRADKVLLAAGARTASLLAQSAPKKLLLHAGERLLATGAVSFYAKLHGAQKDKFSAIPVLKNCLPQVKGEGMSILSDGTIKFNCDLCFTNYQVFPPTGEAMSVAPSQSMYNTWTGPRFLKFFEDRARKTFNGLYGKEVENIKIEAYRMCWDASTPTHDFLISPHPQSDRLYIATGGSFHGWKFLPVIGDYVVDMMQGTLDSDLADRWAWDKKGGDGHSANPTYQIVGDLQDWTRGWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDH9</accession>
    <name>S0EDH9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to KTI12 (TOT4) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433975.1">
        <property type="nucleotide sequence ID" value="XM_023580609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDH9"/>
    <dbReference type="STRING" id="1279085.S0EDH9"/>
    <dbReference type="GeneID" id="35402140"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08664"/>
    <dbReference type="HOGENOM" id="CLU_027147_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002734">
        <property type="entry name" value="Chromatin associated protein KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="337" mass="37705" checksum="65A2F08259CF946D" modified="2013-09-18" version="1">MPLIIVSGLPTSGKSTRSQQLYNYLSNRIADSKYRLHLISDESLSISRSVYDLSSLPAHTRSANASEKDARATIYGAVKRVLSDKDIVILDGLNYIKGWRYQLHCESKAVRTPSCILQIGCSVDKAREVNEARLKKREAGASRAVNKEEATSSATTSGDLIVGSAEPYEPGNWDNLVFRYEEPNPMTRWDSPLFTLIWEDDDAQTSKVFSDLWDAIAGETRKVVRPNQATIQRGREESGDYLYLLDRETSDVVKRIVEAQREGDDVDEVRIPSGSVELTIHLPTGNKVGLPQLQRLRRAFMGLNRGGIGLEAVGDMKSSRLRDTFVTYLNDAFEKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDY8</accession>
    <name>S0EDY8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_12309</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435132.1">
        <property type="nucleotide sequence ID" value="XM_023581900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDY8"/>
    <dbReference type="STRING" id="1279085.S0EDY8"/>
    <dbReference type="GeneID" id="35405765"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12309"/>
    <dbReference type="HOGENOM" id="CLU_004553_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="332"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT73054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="966" mass="107188" checksum="8C9C7DA60428C9AD" modified="2013-09-18" version="1">MTGILAPVTSAFGMPLPSKNRLKGSSATTNSSTPPSPSTSTFSSSSLSSFKTPSRLITSFTPAPVHAPSTPPLSAVSIDSVLSQAKATSLTSSPTSLDMASPETSRPASAVLSIDTRPSAAILSSAFSSPRSASPSRTIRETMRDSAVELRNSARSSMDGTTTTTNGAVVPSSRTSLDSGRTSMSSDWPVHPGEINTIAQLDTLPIGTEVTFRARIETQRPISKVLDFLLLRDQTHSVQGVLARDASNADFITWVRKINPESLVQITGNLKTPPEPIRSATHSNVEVDVVSVHLVNPAQNLPFSNYKPPETLRNRMNARILDLRHPSNQALFRVRSMVSRIFRNTLEEQGFVEINTPKLQPAATESGAAVFAVNYFGRRAFLAQSPQLAKQEAISADFGRVFEIGPVFRAENSNTHRHLTEYTGLDLEMAIDTDYHEVIQFIDMFLKEVFRTVYASRELEVIRKRWPSGEFKWLEETPIIPFSEGIQMLRDDGRDVEEEDLSTPDEMRLGQLVREKYGTDYYVLDKFPANARPFYTAKDPEDPKWTRSFDIFIRGQEICSGGQRIHNVDELRANMAAAGMAEDGMEDYLTAFELGAPPHAGAGLGLERIVAWMLELGDVRYASLFHRDPKSLPTKAPGLPHPEADTTKPHHADSPPPIEKLIANYGDATNTSWLDDRFQIWRHSTGAAVGWVQREKFAMITGDPLCDRSQYTQVIRDFIHYITVDLRLTPFWMLVSYEVQKILASELRWRSLSCTEEQRVDADKHNSAQIDGLAAKARRVEREGVKIHEVKPDEDFISRANPAIEAWKGTRKGKGKQVHLTEVRPWIDQEHRRYFAAEKDGKVISMVVLAKLAPRHGWQVKWALDFPGAVNGAIEVLVSFALQNVSGKVTFGAGVSEKLTPGEHVGGIRAKFLSASYRSIVDSLGLRRKASFRSKFGALGEEIYICYPKHGVGLRDLQNVIKFFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE94</accession>
    <name>S0EE94_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435053.1">
        <property type="nucleotide sequence ID" value="XM_023582530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EE94"/>
    <dbReference type="GeneID" id="35406329"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12873"/>
    <dbReference type="HOGENOM" id="CLU_2073347_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="118" mass="13728" checksum="51E4575108BFE669" modified="2013-09-18" version="1">MPQSTQHPKRFGFRDLLCAIWLTIVSIVTLISVFSSVDIVKMLAWRHRDDFVLSFYFKFSQLFLQSYFKLAQWKAYAKDVPEMGYWGIVDSGRVISLCIVPCAVIWGAGRLFDHLFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEA7</accession>
    <name>S0EEA7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435369.1">
        <property type="nucleotide sequence ID" value="XM_023568007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEA7"/>
    <dbReference type="STRING" id="1279085.S0EEA7"/>
    <dbReference type="GeneID" id="35403492"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10025"/>
    <dbReference type="HOGENOM" id="CLU_729659_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="314"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT73291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="423" mass="46627" checksum="F00C09C5F4E864A7" modified="2013-09-18" version="1">MNAIFNFLSSPLKQPAERPPPSSMPLTASRPSLSPREQRLAKRAADRFSEPAGRSPRSRLSNVSLASTDDNTAEISVVSRRRETIAMAPPPSVKKRISTSTRSSPIHKPKPNGSVSRVTSSPAVRSSPRRRESAELGESSPALIAASPAFPKRVSRVATSSPAVRSSPRARESAGGPPAFASSPASIPKRGINGVSRSSEAAESPRRSSRASRVTEAQINGTKKTPEEQPEEAHFGEEEEEVQAEDDKRYEFVRITDHRWAEGEDEIELLMQWKDGETSWISEELLHTDNRQALFAYWRSQPNGRPTNPENDVYHVFAIRKHRVRNGIPQVLVEWLGYDASENTWEDQDYIEKVAPKLVDAYFDQVKGKGKIQAKPKSQAKSNAKSKAKPKAPARTKAPAKTKAQAKTSARGVTRSSARVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF68</accession>
    <name>S0EF68_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434575.1">
        <property type="nucleotide sequence ID" value="XM_023581973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF68"/>
    <dbReference type="GeneID" id="35405830"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12374"/>
    <dbReference type="HOGENOM" id="CLU_1468568_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495869" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="165" mass="17351" checksum="E36A293EB67DEF45" modified="2013-09-18" version="1">MWSLYFLTALFTISPTIAKKSSKPCPTVTTTATLCTTCVVPACLTIETISSQRNCPSKVPTSGTSFPCSKSKCPSGCATSYTYASAYGTVTKKPKCPTVTETATICSDCIRPMCLTLETVSSVCGCPELPATVTTSYPCGEDCPVGCGTEYVTPTVTPNCKKNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGC8</accession>
    <name>S0EGC8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable flavin-containing monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435932.1">
        <property type="nucleotide sequence ID" value="XM_023568790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGC8"/>
    <dbReference type="STRING" id="1279085.S0EGC8"/>
    <dbReference type="GeneID" id="35402790"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09321"/>
    <dbReference type="HOGENOM" id="CLU_015676_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="637" mass="70814" checksum="1A28C52CFA9FA0D6" modified="2013-09-18" version="1">MGDVIPQSIPRTSRAWAVPGSTNIALAKFPSATKKPSSSNPHEIATSLVSAFNTALKNKDLTALARLFSEDGFWRDHLALSWNFRTVQGPSNILSFLKSCSESKDGLRLTKIEVDSSAPVRKPQFLPIDGAGEVQGVQFFFEIETVRGKGLGLARLIEENGEWKIFTFYTRIQELKGFEEAINDHRSRGVEHGGKPGRKNWAQRREAEADFADGSEPAVLIVGAGQAGLTAAARLKMLGVEALAIDQNDRVGDNWRKRYHQLVLHDPVWYDHMPYLQFPPQWPIFTPKDKLAQFFEAYATLLELNIWMKTSLVETKWDDAKKRWDVTVERTKDDGTKERRTLHPRHLIQATGHSGKKNMPDMKGISDFKGDRLCHSSEFSGARDNSQGKKAIVVGSCNSGHDIAQDFLEKGYDVTMVQRSSTHVVSSKAITDIGLKGVYSEDGPPVDDADLLIHGLPIPVFKALSVTTTKKQADFDKDILSGLNKAGFKTDAGPDDAGLLLKYFQRGGGYYIDVGASQLIADGKIKVKHGQEIETVLPHGLRFADGSELEADEIVFATGYQNMRTQTRVMFGDAIADKVNDVWGFNDEGEMRTIWQKSGHPGFWYHGGNLAMCRYYSKLLALQIKGLEEGLYGYDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGI4</accession>
    <name>S0EGI4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435015.1">
        <property type="nucleotide sequence ID" value="XM_023582487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGI4"/>
    <dbReference type="STRING" id="1279085.S0EGI4"/>
    <dbReference type="GeneID" id="35406290"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12834"/>
    <dbReference type="HOGENOM" id="CLU_016056_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052701">
        <property type="entry name" value="GAG_Ulvan_Degrading_Sulfatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751">
        <property type="entry name" value="SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751:SF3">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="2">
        <location>
            <begin position="435"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="846" mass="96144" checksum="7DDAB8515D17A867" modified="2013-09-18" version="1">MAPFRRICLLYASKLANQRLAFTLTLLAVCAAKGVHLHNHRASVTPKRMLLFFFSFFTQDILLLLLIRLLLSHWVPSAAKPRSIVNTLAFSLITYNTIICTVSVSFYLVSGSEIHWRNIGFMADPTAQAIILSGLTAFIGVFCVFACLGALLQVPCYSLFGWGADLVNWPLTFICRQLGHRFDYDALFQREDLSWLDIESTSYHDKEFKENFNSPSVSLLSSPRSSRGGSPVRRSRLSRFLRILPYPIVTLLLTALFILTFIRPKDPSLIFLSWTTGLLPFIDFASSPFLDNLPSVFGKGVQRTWDDRTALVQPTPFSWLPMDIPALDGFKDWYLDQPHYSAKSDPMRVSNLDEPLRDSLRGKLQKLNIRHVVLFFLESTRHDVFPIKKDGLVWNRFAETFPNGLPKDVQEKLANLTPTANFITGDYSDGFEHASRPKRGGIRFTNAHTSGTYTLKSLTGSICGISPLAADFNLDYSHHIYQPCLPHIFNALNKAEEKQARTKEASQKDKWKSYFFQAAKLNYDSHGALMSAMGFPDEGIIGQEYLRSANARHGAVTLENINDFAFEEDPLEDYITDVFENARTENNRVFLSHITSTSHHRFHMPKKEKYTPLANGGHLDMMSRYINTIGYEDRWIRKVLGILDKQGVANETLVIFQGDHGVSLPENDIASPYYNPNVGVEHVPLVLSHPQLPAFDVDEGVHATQILPTILDILLETGSLSKTSREAAQDLIRNYEGQSLLRPLATGNGQWQFTITNPGRAMLSIRDGRYPERHLVVPIIEHVAWKLADLTKDPYEHNPVQALDFKSFLQEVEQRFGREVAEWAEEGAFMTRWFIKENSKRWRFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH01</accession>
    <name>S0EH01_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435180.1">
        <property type="nucleotide sequence ID" value="XM_023567779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH01"/>
    <dbReference type="GeneID" id="35406380"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12924"/>
    <dbReference type="HOGENOM" id="CLU_016835_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35606">
        <property type="entry name" value="CELLULOSE-BINDING FAMILY II PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35606:SF4">
        <property type="entry name" value="CELLULOSE-BINDING FAMILY II PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485925" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT73102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="408" mass="45052" checksum="1BB4C0AC2DDF0A3D" modified="2013-09-18" version="1">MRVSTISAVFSGLAVSAIAQSDLDGAVWKALLAEPQSKRGFSDMPRNRPVKRQSGWNPPADLKAPLQEVWEHYEKTYDGGLDANVNTGFHQIMANKGYLNICVRWDSSTTVTEAERTKIASAYNAQYQKWFKWLYGYNGFPYDEVKVNIVAYAVKDKSQLQGSTAGYEVYTELDADGVPMCPVACARDAHLDGDYSGCKAGADRHYDHSLWLKDGLEGGFGHNWGQEVGREYFMNNLDSDNIHILLHEMGHTFALDDFYDWTPTGITKFIMLAGASMEITDFDGWMYRNWWYYLSQKNNWGSGKSSTDIAPVSSESKPTTKTAASATKTSTPKPSTTTKAVITKPVSTKKATATKAPVTQVHSVETTSSAEVAPWGQCGGINWTGSKKCASGAKCTKRNDYYSQCVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH50</accession>
    <name>S0EH50_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_10399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436429.1">
        <property type="nucleotide sequence ID" value="XM_023569178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH50"/>
    <dbReference type="STRING" id="1279085.S0EH50"/>
    <dbReference type="GeneID" id="35403864"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10399"/>
    <dbReference type="HOGENOM" id="CLU_281873_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050966">
        <property type="entry name" value="Glutamyl_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462:SF8">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="600"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT74351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1110" mass="122650" checksum="A6B90EC84F250F44" modified="2013-09-18" version="1">MFSNPETLSNCLTLATVAIMTTNRGRDTISNQTLEEVDRRFNIGRLDEFWRRGALLKYVKCALQSCSDSKFGGCPQELWAFQCQAITSENIRDLGKIMGAEYCDKADPGIDYDIAGPGIIVAYLIQFTIVLLFASCYKITKTWTRNFTLISLLPFHGPAGAFETAFQWQEMVSRSSFGVTVASTLVDLQEAQAVFLGTISIAAIVTFSSSSGTGLGNISSLLSWLTNNLTLILQKTHNRWWYTLALVFINWVLVMLIARPQTVDESSLLKHFTESSSLERCGNHIGPRTFCQTFNKPAAGGSSSTTGEKSGYLDRDAENFFKFHSRTQTPMHLVMVFLILDWILAMFRMYLFEQIEWLSHKAHALTDSLPFRLNSSDSQRFFVLFTEAIWISMEVLTIVMGAIGVQEFAAFMHLLSGGESGNESKVALSKWGFGQLVAVCVWVPVILKFASLMVDGALPGWRKRLGQFIEITQRKETEPDRNDIIMETLILPRSTRRGQADELEGHWCMRQALHFFASSSPISLPCPERTYARWPLRDVPRTPATNVLPIGPEADGIPTVFDDDSRTLVDPVYYRPGGKYHSIVKLQIRFEGQDASDTRHAQATGWLIMPHLIITAAHCVYDHTHDFGKAVQVRAFVGYNGKNSVDQAGVQFRRGLKVVVPKDWIISDTNRASDVAFIKVEEFNDIVRIAQQPTAGILNKMLLSVVGYPCDKSLGDEPGAQMYEMTRRIDCDLSKTAVNLLEHTISFASGQSGSPVLISGESKAIGVSSYGTGTRNTATVFRGSYGTYLSGMSAVMFGLDRAPAGSEDIRYTMTIGRPEGSVMEEPLSDGKTFWAIFRKVTSVGQKVDRSILRTGFPFMGQVGGPIAAVAGTALGVMSKLGADTSIDVRSVHVNYRQCAARAIIAEAAMQTIIKMDPHKVNDYRIFDKMEDQFPETKDVVPRVAKLITPGIVESALRISVNAQGAGEGMSRLYPKLPPVSGSLSDDGKSFADAFTRYTNQGDDNEMSEFFASIVKTALAARPPKMDDITRTIGEPELSVTDMSTHIEILCHRALIGDICLQSLIAIPLDQIMQKGLFDHFVATVGNIGRTVIEVAPVVVQNILNNLKQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHB4</accession>
    <name>S0EHB4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to acetylxylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_10081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435315.1">
        <property type="nucleotide sequence ID" value="XM_023567945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHB4"/>
    <dbReference type="STRING" id="1279085.S0EHB4"/>
    <dbReference type="GeneID" id="35403548"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10081"/>
    <dbReference type="HOGENOM" id="CLU_005594_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496025" evidence="8">
        <location>
            <begin position="26"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="9">
        <location>
            <begin position="84"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="887"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="942"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="1117"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1215" mass="133586" checksum="106AA4FD97A2652E" modified="2013-09-18" version="1">MQIKHRGLYWPLAAVSLLFISHTTAYESPDGIEPYGHGNAPDVVSWDTSWNESYPASEGDEPSLGADRGLSSRADDFYLRVMPLGASITQGYLSTDNNGYRKWLRSQLRYKGWKVNMVGSKQNGDMKDRDNEGWPGYVIDQVHNEFRKSMWMKPNLVLINAGTNDCNQKIDIDGAGGRMKALVDDIYSNIPGVTIVLSTIVRSTNVTNDACASKVSKQIRQLVKTYRGQRIGLADINPVLPTSMLQKDGIHPTDAGYKLFASVWWDAIRKVQADIQPPAKVSGIDDAVNEKSSECKKTAGNSRAPKQSQRGSGHDDGIYRHYSHAQGVLKSLRLENGGDSASLIKDYPWHVLFANIVLNSANSPRSYALDDMIRIHHEKDGTNTYWYRQNQGGGKFAASKRFDVDMDCNDGPRYAFADFNNDGLDDFFCLKSGSAVWVSINQGGNPPKFKSIGQVVGKHDGYEATDVRIADIDGDGRADYCLVEDSGAVICSRNGGTGVKYAWQGFKTAKGLRETVFDKNPKSAASKSGVVFADLNGDFRDEYMWISDTGSVHTWNNMRGWGKGIVPEWRDAGLTHKGQAAKGIQNRIKFGRIYGSGRRDYIYLRSDKTGIDMVVWENRGFGGTKRKADGNFYCDMRGTGSDDYVWIYFDGHAAELNANIHNPPLWGNDLKIELKVPGPRVGIHLADWTGDGKCDVLVQNEATGALTLYENTYETGSKSVTFTNKGVVTPATCSQGWGVSPFDRGMRLADIDGDGRADVMCLEPNGRITGWLNLKSGMENVGQVKFSEGRERADIRFADVENSGRADIIYLDKYTGAATVFKNLGRKAGTGSSFNWSNRGVLYAPIDRGETMHFTNQGGLGRADLVHVLPFTNKAYTYFNECGASGGDDGPITDPGLPKYSTGGQDGGTDDGSEDGGGSSDDCSKPTFDGDSKVILSENFPDPSFVFDFESCTWYSFGSQDKGKLVQMARYNKAKDKWELLSDDPLKDAGAWGQNLDIVAPDVQWNGKQWVMYYSAFTQDDNDGKRCIGVAFSDSIRGPYTPRDEPLVCQLDKGGVIDPSAFYDPGSDTRWVVYKIDGNRICGKTSIMLQQVENDGFTLKDDPVEILSETDDEKLLETPSLVYEDGSYLLFYSSGCYTSDKYSIKYATSGSISGPYDRGDDEVLGSIAGSIQSPGSASSNGNGHLLFAAWCDKDLTTRCLYSASYKFEDGQVTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHF1</accession>
    <name>S0EHF1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to 3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436292.1">
        <property type="nucleotide sequence ID" value="XM_023569018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHF1"/>
    <dbReference type="STRING" id="1279085.S0EHF1"/>
    <dbReference type="GeneID" id="35403721"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10256"/>
    <dbReference type="HOGENOM" id="CLU_031652_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="2">
        <location>
            <begin position="188"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="603" mass="66378" checksum="C37E6D79E816D483" modified="2013-09-18" version="1">MGAFTLPSTEGRTVAVLGGGVLGRRIACGWAASGFDVVIRDPSPEQRAAAVEYCNTSMSLYSDFESRGTVAAFEDLSEAVVQAWLVIEAVPEKLPLKISTFADLEKLTPHDAILASNSSSYKSREMIGGLLPETRRRVLNMHYYMPPGNRVVELMTNGETDESIFPFLREKLEEIKFHPYIARKESTGFIFNRLWAAIKREVLNILAEEVSTPEEIEKLWKEMWYGKESGPVEMMDAVGLDTVSFIEQHYVDERGLPDTPVKFLQKYIDDGRLGAKSDKGGLLPPRKSVQSDHEPSLYFLDIGLSSGNAKGYASAGRVLVGSSNGEPMKTLVSGQRLPDGIDISKSAGKLFWTCMGNPSANDGAILSCNLDGTDLEEIVPQGLVHTPKQLTVDNTNSKLYFADREGMRIMRCNFDGSQLEVLVQTGDWEVDGHMLDPTRWCVGITVSPSTGKFYWTQKGPSKGGKGRILQANIDFQPGEEAQSRTDIEVLFQGLPEPIDLEIDEDENVLYWTDRGELPNGNTINRAKLDGIAKVTHDGPSNPGVHYEVVTRGLHEAIGIKLDSKNHRIFVTDLGGSVYQFDIDGGNRKRVYEGSGAFAGITIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI33</accession>
    <name>S0EI33_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435575.1">
        <property type="nucleotide sequence ID" value="XM_023568367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI33"/>
    <dbReference type="STRING" id="1279085.S0EI33"/>
    <dbReference type="GeneID" id="35403169"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09701"/>
    <dbReference type="HOGENOM" id="CLU_031404_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="489" mass="54670" checksum="EFA61629873749E9" modified="2013-09-18" version="1">MADSSPTVASPPRRNSQQANTPQSTTSTNNNRDGALVLHASSSATAWWSRFRYPVITAGIVLFISPFTFLWSGQESIDPANYAERTKRILKTTPLIDGHNDLPFMLRLELKNRIYDERFDFTNRLLGHTDLQRLRQGMVGGQFWSVYVDCDEQQKHFEDPSWIVRDTLEQIDVTRRFIREHPKDLEYCDTAACARKAFKSGRIASMIGIEGGHQVGGSIASLRQMYELGARYMTITHNCDNAFGMAASTVASGTADTGLAKLGKVAIREMNRLGMMVDLSHVSHQTMRDVLSIARAPVIFSHSGAYAIEPHLRNVPDDVLRQVNHNGGIVMAVFLNRFLNMKHPEQASIHDVADHIFHIAEVCGWTCVGIGADFFGMSNVPIGLEDVSKYPSLMEVLMQRGATDEQIRLLAGENILRVWGNIEKSAKTIQATGEKPVEEEYEGREWHKGFSTDPYMLRGGLEEALRNGAKIEEDVFDLDAEGRPKILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ57</accession>
    <name>S0EJ57_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436902.1">
        <property type="nucleotide sequence ID" value="XM_023569730.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EJ57"/>
    <dbReference type="GeneID" id="35404358"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10894"/>
    <dbReference type="HOGENOM" id="CLU_005545_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="814"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
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        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1364" mass="148450" checksum="013E0B3D05798F4E" modified="2013-09-18" version="1">MASGPPYNGYQVPPGPGVPNQGPPPPTQHYAQSPHLQQYSSPPPHQYVHGQQPVYQSPHPGHAQQAYQTPQPPPAQYAQSPQGVTQQYAPAQQHHYQSPPPPGHYQVNQSGQSPQAQHNQSPQGQYPQQQTPGQQPSYQTSTYGVAAPPTPAQHQQQYQQQAAQFATRPSTQAQLQSTAQSLFKSGKGILGNLASNIKSKYPTSAPSGAPASSGTSYTGEAPKPTYNPAQHPTQTPLSPTNSFPQGYGQTQPQQPYTNQAPPTPQQSVPPAAPGYPPSQHQAAPATSPSQQPSAPGQPPHLSWQERLEAAQHPSAGFQPSQANVHAGAQGTVPQPPVQSPPGASPYPQPVLHHQQSTPYQTTPAPPADQSFPQGAGPAASPGYGQSPPEALSPHQQHQSAPPQLQQQGSLPQQGGVSTPYNPTLSSPPPPPQTAPQSGPPVGPPNHGSPALQQQPQYHQQTGTTNPQDPTATQQVGLVSAYQTVPASATHSTHQVLPPQQLYQSPPPQGYPQQQAPAAYDPMAVSGVSPTAHTVPAPLIQSAPIRHPQGPPATQSPHQQHQSPPVQQIVSPAAATQHQQAPFQSVSGPQGQYYTTNQAQVHQTGGLPGGVQPIAPPGQAHSYPPPPPLQPQHDVNPVATPAPNQFQPYSPTVEQHAPPSQYLQHPEVPATSHRTSQHDTSPPAGEINPGQANPPPTVPGQQFQPYQPVPEATNFQPPPANANYGHSQPAAYGYQQDPMASLSAQMSSLNVLNSGHPPTASNTDQAARQDGPRGPPPCQATGMSSDVLPYCPEDRTVSYSLDWYRFIAVPQYLICTRCYTDYVQSTHLAGHFERYHSPEGIESKCGFWSPRAREVLWPQALQNNDVRPLQEWMEKSLTIKPCKGRVWTTGADEVKWWGLVNDEIDGFISCDACYEDHVVGTAFESRFQPYRQQGQDEKWMCDLCIPYIAKIAVKMAKQNHWNGFVEAAKVRVQLPLCEGRDEESNSGHWMLPRRKIKDMTICEACYLDKLALTPFGNEFERHIRAEGFDAFVESIGQRWKCKLTDTAVSMSIALEAAIYRRDFDVFWNAANAIADLVPCTIHGIVRGNWWTVVGGCADYDVCEACYKGIVETSGLEKFFEPAQRDQTVDIICNFCPGTPRWGSFITKFAEALDKGVFSLYSDYIKKWAGVPPCPGIKNRGKSKWWGHPEALACQDCWLNFVADTPLGDSVPVKEVYDERTLICQLWSPRMRNMWLVACAAGPPGSPESQKALDEFKAFGSRRLQVYNATVPHIEMIQQMQMMKQMQAMQQGQLSLMYQGMNGMAAISGTTDGYLHGNSSVGYYETEHGVTAANMMNNMHAGMADANKMSDWQTIMQLQATWMEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ99</accession>
    <name>S0EJ99_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436788.1">
        <property type="nucleotide sequence ID" value="XM_023569594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ99"/>
    <dbReference type="GeneID" id="35404237"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10773"/>
    <dbReference type="HOGENOM" id="CLU_1948978_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="129" mass="14698" checksum="8E236F3E0C58DF36" modified="2013-09-18" version="1">MSIPGKFMIIVGGKPVANPRDNGEPMIQAQPGDPAAIFEFRDGRLFSGEWALGRLNYEDRSMMPKRVLWRKREEVNDLQPVQFQEDGGPPELKFSGMLHHTVTSAVSRLTTSDRFWSGIFRQQALFTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJJ9</accession>
    <name>S0EJJ9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_11221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437259.1">
        <property type="nucleotide sequence ID" value="XM_023570095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJJ9"/>
    <dbReference type="STRING" id="1279085.S0EJJ9"/>
    <dbReference type="GeneID" id="35404684"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11221"/>
    <dbReference type="HOGENOM" id="CLU_044885_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="396" mass="45279" checksum="FD78BC24F474A586" modified="2013-09-18" version="1">MSSDLSRFYCNYTGCERSYKKKEHLLRHERDHLNLRSFACRLCPATFNRSDLLKRHETISHPLGQGVLQEDAEPSTEERVPESQEAVPAYELGESPVNALDSFLGTELQDLNLASNPAMQLLQESCRNELESSYFLHFHPHWPLLHKRTFLQSESPPELTAAVLTAGLWVLDTSETRDKARFYHDALLKTLYEQLFKLPELATGSSGSRAEFLPTFQVLLISLIICTYRGVETFPSPLFHSKQVWQLFQSMGVYDQKAIDDRNSSPMIRECYQRLALLHFKVHVHLNSILMSHFSQFKPFDYLTPSMLKVRIPSSGLHWEGGDGSVPCQGHGSRTVADFLGDYTELTRLSDLIAWDFTLGMVIGCYLVRPAGETHRQLMIRLDPFLFIHLKSSEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJK5</accession>
    <name>S0EJK5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Beta-glucosidase cel3A</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Gentiobiase cel3A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FFUJ_11227</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437264.1">
        <property type="nucleotide sequence ID" value="XM_023570102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJK5"/>
    <dbReference type="STRING" id="1279085.S0EJK5"/>
    <dbReference type="GeneID" id="35404690"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11227"/>
    <dbReference type="HOGENOM" id="CLU_004542_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485699" description="Beta-glucosidase cel3A" evidence="18">
        <location>
            <begin position="27"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="19">
        <location>
            <begin position="695"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCT75186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="774" mass="84701" checksum="05EA296C6E405A05" modified="2013-09-18" version="1">MRICEVLPDMMWSTKLLCLALQVASSFSLPAEIPTEEYPSPQGTGKGIWKDAYEKAQQFVDRLTLEEKVNVTRGFAADNVCAGNTGTIPRLGWPGLCLHDAGNGVRATDFVNSYPSALHVGASWDKNLTYQRGYYMGKEFKAKGVNVLLGPNVGPLGRTPLGGRNWEGFSVDPYLTGQLSAESIIGHQDAGVIANVKHFIANEQETYRRPYFGIEAVSSNVDDKTLHEYYLWPFVDSVRAGVASVMCSYNRVNGTYACENSKLMNGLLKTELEFEGFVLLDWNAQHNLESANAGLDMVMPMGGFWGENLTMAVENGTVKEERVTDMATRQALLNTEILAAWYLVGQDVDFPIPGIGMKNLSLPHEQVEARISESRPTLLEGAIAGHVLVKNENNTLPFAQKPKMISVFGYDATVAKTKNTDNLFQLGYTSSPEMGQAVLGTEEHFDQAAKGGTIVSGGRAAANSPPYISDPLSAIQQRAAKDGSWVNWDLSSPNPDVNGATDVCLVFINAMATEGWDRDGLHDDFSDALILNVASKCANTIVTIHAAGIRLVDQWIEHPNITATIIAHLPGQDSGEALVKLLYGEADFSGKLPYTLAKNESDYTPYKPCGLEEGSKDPQCDFTEGVYLDYRSFDDRDVTPRFEFGFGLGYTEFEYSDLVVKVAETSASAAATDLWSTFATAQATVSNVGKRDGEEVAQMYVAIPNSPPKQLRGFEKVKISKGEAADIPFELTRRDLSVWDVVKQDWTLQSGNYTIFVGSSSRALPLKESFTIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK01</accession>
    <name>S0EK01_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436280.1">
        <property type="nucleotide sequence ID" value="XM_023569005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK01"/>
    <dbReference type="GeneID" id="35403709"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10244"/>
    <dbReference type="HOGENOM" id="CLU_885783_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="374" mass="42804" checksum="31AAC93E7ACF354D" modified="2013-09-18" version="1">MAFLELTAPRSPTPESASTISSEDNKLVALTPPSHTFAEATNTTSAEVNVDNTDKVSLQSPIKDHELKEPKAFDQMIAHLNAMRAKVQALESENIELKAQVEHEKSSKEQFSNSLDEANRNWRFAESESAAKVQALESENNEIKAQVEYEKSFKEHYSRSLDEANRNWHSAEFEAAAKEAELGRVRERLSLIEAQVTEQAELHAVKEQNTELQARYRYQFYLTTHHHVQTLKHMMHDWKAQVVQKIDEEYEKNKEKENDSAAAVDAEYERLKALIEGHDYIITNIKKGNEKFATLIKDLRESEYPTLTSDLAADRFEAFLSEREKMVAQLEQEKQETVEMIPTETKEPTKAERKKAKKAAKKAAKKAKKANEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK44</accession>
    <name>S0EK44_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein piccolo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437227.1">
        <property type="nucleotide sequence ID" value="XM_023569559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK44"/>
    <dbReference type="STRING" id="1279085.S0EK44"/>
    <dbReference type="GeneID" id="35404205"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10741"/>
    <dbReference type="HOGENOM" id="CLU_847405_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="34847" checksum="4B36B365A2ACA36D" modified="2013-09-18" version="1">MFSQKPKKPVAGNKGPAAPAQRPPAGRPAQRPQPAQRPSQPAQRPAQRPAGYQPVTAPRSVAGAPVVGRQPAPNHGMQMTQMKKPQQAARPPAKKPAPAQGQKAGLPKGHAPQSGGRPVQRAGPAPVQSYHPGHPQQAHPQQSHKKSSSNMKYAAGGAVVGAAGAGAAMYYLNNDSNEPTYVINNYDNSQGPENITCTQYNQYEGDYIDNGDYRYDSDGDRQYSPNSPDDDNRYYDNDQGQYANDTNYGNQYENDQVDTSYNATRYQQPSDQQDYSNGNNNGGDGGNDDCCGCDNCCECDNCCDCDGCCGCCGDDNGKDGGGGCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKH3</accession>
    <name>S0EKH3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437544.1">
        <property type="nucleotide sequence ID" value="XM_023570431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKH3"/>
    <dbReference type="STRING" id="1279085.S0EKH3"/>
    <dbReference type="GeneID" id="35404984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11522"/>
    <dbReference type="HOGENOM" id="CLU_070126_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496086" evidence="1">
        <location>
            <begin position="28"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="295" mass="31902" checksum="CDCD345511F664F0" modified="2013-09-18" version="1">MSIRTMSSRLLAAALALGGLSVGQTTGNFNFLTYNVAGLPAIINNNEVPGDKGTNANLIGTVLATQKYDVVHMQEDFNYHAYIYATDNHPYRTPTSGGVPFGDGLNTVANYDWTGLVRKKWNKCNLNSGDCLTPKGFSFMRMKIQSIEVDLYNLHADAGSDQGDVDARSAGIDQILAYINANSQGRAVIVAGDTNDRWTNAGRSINKLTDAGFSDSWIQLIQGGKFPTAGATANPCKVPAADNTCEIVDKVFYRSGSSVKLTAKSFNYVPKVFVQPDGNILSDHNPVLVEFTWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKI7</accession>
    <name>S0EKI7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to Metal tolerance protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_11189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437183.1">
        <property type="nucleotide sequence ID" value="XM_023570059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKI7"/>
    <dbReference type="STRING" id="1279085.S0EKI7"/>
    <dbReference type="GeneID" id="35404653"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11189"/>
    <dbReference type="HOGENOM" id="CLU_013430_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF13">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="76"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="282"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT75105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="365" mass="41546" checksum="EC21DE0F1524A3EF" modified="2013-09-18" version="1">MEEVSDPFDLTSRRRQDVTKEQIKNDYPQGDARLLRKYYTRQNKLIDQFLGVDDEERAQAEEEARVAGKIKFAVNASFVVNFCLFVIQLYAAISTGSLALFATAADAFMDLVSSFVMLITSWLAARPSIYKYPVGRTRIETIGVILFCALMTTVAVQLLIESARTLGTGKTESEELHLIPIIFVCVAIFSKASLMLYCMTYRKYPSVHVFFIDHRNDIAVNSFGLIMSVVGDKFIWYLDPIGAICIALLILFSWISNAFEQIWLLVGKAAPQEFIAKLIYMSITHDDQISMVETCRAYHAGQKYYVEVDIVMDEQTSLKISHDVAQSLQRKIEGLGDVERAFVHVDYECEHNIHEEHKPLYDRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKU7</accession>
    <name>S0EKU7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to quinate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_11483</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437507.1">
        <property type="nucleotide sequence ID" value="XM_023570387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKU7"/>
    <dbReference type="GeneID" id="35404945"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11483"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF21">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="31"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT75461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="530" mass="58317" checksum="2D7DF454927F4CE7" modified="2013-09-18" version="1">MTIHGMFRRIVRNDAIHVDPPEIYNWRVIALTASACFAGALFGVDAGIIGGVLAMPDFKREFGLDTRPKEDAADLAGNLVTTMQAGAIAGALLSSPFADRKGRKSALLLVAVTGFVGGIMQAFSYGHLSVFYIGRFVEGLGLGAGTMLAPTYVSENSPRAIRGFLVGFFQLLLVLGGMTAYFINYGSLLHLPGKATWMVPLGCQSICPALLFFSMLFCPESPRWLASRDQWEKAGAVLSDVRKLPVDHAYIQQELLELKTQIDQEREIMQDTGFWAIQKECWTLPWNRKRALLTVAIVTLGQWTGTGAINYYAPTIFSGLGLSSTTTALFAQGIYGVVKVVTCLIFIFFLADSLGRRKSFMFGGAIQAFCMFFVGFYLRFGPEPGEGDHPPPAGIAALAMIYIFAAAFNMSWGPVSWIYVSEIPTNRLRAYNVALASFTHWVHNLAVSKSTPVMLLHDPWRAYFIFGSFNLFMAIAAYWIPETKGISLERMDEVFGVADFSNVEDVGIAARRAKRIDDEDVEDIQAPNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL32</accession>
    <name>S0EL32_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436685.1">
        <property type="nucleotide sequence ID" value="XM_023569473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL32"/>
    <dbReference type="STRING" id="1279085.S0EL32"/>
    <dbReference type="GeneID" id="35404128"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10664"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="250" mass="27427" checksum="47AB7B56ADB3DA29" modified="2013-09-18" version="1">MSSNPTIVFAPGAWHLASCFDPIREALHSRGWTTEAVEYPSVGAEPPTKGLDDDADAVRTVLQRLADKGEQIVLVVHSYGGLVGANAVKGLGYRQRKEQGLPGGVIMFVYLAAFVTPLGLSIKQMLGGQFLPWMNPKGDYVYADTPEEVFYHDLSGDALESAMKTLKHQSGRVFTDTVTYEPWHDIETMYFFCDEDKALFPVVQEQMAGMLGPNAVQFHSKASHSVFLSKVDETVKGVELAVEEGKKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELC9</accession>
    <name>S0ELC9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435266.1">
        <property type="nucleotide sequence ID" value="XM_023567887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELC9"/>
    <dbReference type="GeneID" id="35403601"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10135"/>
    <dbReference type="HOGENOM" id="CLU_122516_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="151" mass="17295" checksum="7A0576DDFFB54BF0" modified="2013-09-18" version="1">MAKSKSKTEASSETDTAPTEPAARPVSTCGSEHLLMTTRRQASEQYAKAAKAEKAYRTKKRAALARANYNETKTHFKEAFSHLWLALKGVFPAIKNSRYLLGERRVKRRQEAEKKKRERNLERKKKLEEQLAKEEAEAEADGKKEEDKVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELU7</accession>
    <name>S0ELU7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436955.1">
        <property type="nucleotide sequence ID" value="XM_023569791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELU7"/>
    <dbReference type="STRING" id="1279085.S0ELU7"/>
    <dbReference type="GeneID" id="35404413"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10949"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="498" mass="53905" checksum="6EAA0F710F6DF25B" modified="2013-09-18" version="1">MSSELYQQLTAPNGVTYNQPLGLFINNEWRRSRAEEFISVVSPIDENEIAKVHAGGEEDTDDAVKAARAALKGPWSHLSGTERGEMMRKLADLVDAATNELATIDTWNNGKRFSSAQGDVGGLTGVLRYYAGFADKQYGQVISTTEKKFAYTTVGPIGVCGQIIPWNYPLGMAGWKIAPALAAGNCVVLKPAEQTPLSILFFADIVKKAGFPPGVINIVNGFGKKAGVALAAHMDLDKIAFTGSTATGREVTRLAANNLKEITIESGGKSPLLVFEDADLDQAIKWSHYGIMANQGQICTATSRILVHEKVYPQFIELFKERVKSCKIGNPFDIDTFQGPQVSKAQYERVLSFIESGKAEGATVALGGQPTAVNGKGFYIEPTIFINASDDMKIDREEIFGPVAVISPFQTEDEAVRRANDTIYGLGAAIFTQDITRAHLIANKIDAGMVWINSSNDSDFRIPFGGVKQSGIGRELGEEGIRAYTSRRSVHVNVGNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELZ8</accession>
    <name>S0ELZ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to tubulin-tyrosine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437010.1">
        <property type="nucleotide sequence ID" value="XM_023569854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELZ8"/>
    <dbReference type="STRING" id="1279085.S0ELZ8"/>
    <dbReference type="GeneID" id="35404470"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11006"/>
    <dbReference type="HOGENOM" id="CLU_031301_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="470" mass="52867" checksum="AD4C0A9C757DEAEB" modified="2013-09-18" version="1">MHVYVHSANPWLDGHVQECIKRHVPDAICHKNFTDIPEDADTVYQLLNGWELNHHFAVLNRAKHGLLNAYPNSDALARKDHMASVVDYWITKRPESVLKGHSPATVKLSLDYSEYVEDALAAADDLTLLYSLEDNEAKDSSERSWWILKPAMIDCGHGIRIFSTIDELAGNLELAADISEEDEESEEDAETPDTKFESDDSAEGFKPSLSAPGLDSLDALITATGKLSVQGTNKIQDLVIDENERIPSALLREFVAQQYIVNIPPIDGRKWHVRAYVLSVGRLKVHVFNEMLALLALDDYEPPWKNPSLKSSLTNTALQDEEEFTSKESMRDFWKIEDDLLPGDWKKRVFDQACQISGELLRAAAHTMADKFTPLDKCFELFAIDFLIDSKGTAWLLEVNETPAFYEQGYAGELAQRLMESLICVTLEHMGMADMENEKNVEARGRMVEVLDATKELAKSNITEILPGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM29</accession>
    <name>S0EM29_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to short-chain dehydrogenase/reductase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437035.1">
        <property type="nucleotide sequence ID" value="XM_023569882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM29"/>
    <dbReference type="STRING" id="1279085.S0EM29"/>
    <dbReference type="GeneID" id="35404495"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11031"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF35">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="365" mass="40328" checksum="FAE0A1D057E643A7" modified="2013-09-18" version="1">MSAELEHQAAFEATFRGWLSRQFTTPKPLPTTLEPAEKTAIITGSNTGLGFEASRQLLKLGLSHLIMAVRSHTKGDAAASILRDEFPQSTVSVWILDMESYDSVTAFAARCATLPRIDIVILNAALIKPSLTRASTGHELTMQVVYLSTALLTILLLPILKSKRTAAGTRPPVITVVGSDLAYRADMHTMGPVVEQSDKDQGYNQFVWYARSKLLLTFFVSTLAESVNPNHVIVNMVNPGTTRGTAFLREFSPLLERLAGALQLIFARPVDIAATNYLDACLLRGIESHGSFISDWSIKPYPAIWYTSVGKDLGKTLWEETMREFEPFGVAKIIEDLKKTQFGDREASKPRTSIPTERRTEANLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMB2</accession>
    <name>S0EMB2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable spherulin 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438007.1">
        <property type="nucleotide sequence ID" value="XM_023570977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMB2"/>
    <dbReference type="STRING" id="1279085.S0EMB2"/>
    <dbReference type="GeneID" id="35405473"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12013"/>
    <dbReference type="HOGENOM" id="CLU_061239_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013288744" evidence="6">
        <location>
            <begin position="16"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="75"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="262" mass="27619" checksum="24F8CFE1912D9928" modified="2013-09-18" version="1">MQFLSILLLAGSALAAPRAAQSSHHARGDSIDDMLPPIVPINTRSGDRDLISKIITAPTQAERVKLLNQPGDFVFDFKAATGAGEASGKGGRSVSATALTMPALIGNGASMTVAFLGPCGMNTAHVHNRATELNIIVKGRLVTNFVVENGAKPIANTMDTFQMSVFPQGAIHQEFNPDCEDAVFVAAFDNADPGVNQIAQNFFALNGDVVQATLGGVQTIDGKDIESFRPHIPANIALGIDACLNKCGIKRNAKRDLSELLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMD5</accession>
    <name>S0EMD5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to transcriptional activator Mut3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_12043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438032.1">
        <property type="nucleotide sequence ID" value="XM_023571010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMD5"/>
    <dbReference type="STRING" id="1279085.S0EMD5"/>
    <dbReference type="GeneID" id="35405503"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12043"/>
    <dbReference type="HOGENOM" id="CLU_018186_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT75986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="695" mass="78197" checksum="4652B2DA465F6258" modified="2013-09-18" version="1">MPVTGPAPSNRRMPLSCEPCRRRKIKCPRNNSRGRTPCDTCVRRGVPVNECIYLRDQSSLRNVLVPRHADNSALVARIDRLEELLRQSVSSAGPEPRTPHTGLDLEEEQEAGPGQEQAADFLSPESTLQQSATTWSSTQSDSSLTQPHTAMPPVGVIIRYESGHERFESVSSQLSPMIQNNPVVVGVKTDMAENICGSMPFSMNNSSIADLLELLPPASYCEQLKKLYFDTFAPLFHILHDPTFEIDYLRFQSDPEKVSLPWLALLFAILSIAVIALPQDSPLLRELGKRKSVLDNMSLLSSRFRGGVMKCLEADHYLWRHNMNTLQTLVILIYGINHTHGQSWALLGAARNIALSLGCHIEPTVFQMDPIRAEERRRCWAGLKMLYTIQNTTLGILDATHIPSTVKPPLDVNDNELVVGYHIPESREGPTQMSYLLLKFELYDLCTRICSHVFESSRTASYDKVQALDGEIVAMREKLNYKYLFDVSIAAHHSVQLNILFGYTHQLTLLLHRLVLRQGASGYTREDWLSSQAKCIESSKDLLGIHHAFHENPNFHPYQWYNRGLGSFHAFHAAVCLAHICMSGINLDSSTKNSFQELIRDSLQVFRYFMETGISAICTKATPILEKLLSVMNTRDSSTGCESIYHPSDSSHGNDAELFDEYIENLAPQQWLSPSNMGWEGWATILEHGSIENIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPD6</accession>
    <name>S0EPD6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437011.1">
        <property type="nucleotide sequence ID" value="XM_023569855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPD6"/>
    <dbReference type="GeneID" id="35404471"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11007"/>
    <dbReference type="HOGENOM" id="CLU_1120223_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="246" mass="28202" checksum="270C56945AB48860" modified="2013-09-18" version="1">MRNQNFYSPSSEDMPAPVKFPRRTSSLRNKRPLPHIVTTIEPGYNRQLFTLHECADDASRSYHKRSFSLSSSRTPTTPGHIDSPFSDVAPTLRMFSTSYVMTKPLENSGSYFQRNINDQPEVPGPSQQKPQGKVQNWLSKLPDRREPSFEERERDDEVCGISKPRQPCAVVDASTTPTGAQKQFLDLEEDDESESSDSEETGDLDGYHEALFRLSGTRNDCRPIFRASMRRQFPIDREREAHLKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPP0</accession>
    <name>S0EPP0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to DNA repair exonuclease SIA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437531.1">
        <property type="nucleotide sequence ID" value="XM_023570415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPP0"/>
    <dbReference type="STRING" id="1279085.S0EPP0"/>
    <dbReference type="GeneID" id="35404971"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11509"/>
    <dbReference type="HOGENOM" id="CLU_019692_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496300" evidence="1">
        <location>
            <begin position="21"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="436" mass="47800" checksum="1E067AFC0901581B" modified="2013-09-18" version="1">MLRSLALTSFLAGQSLRAAAQRDQVDNSNLDPLKFKSDGTFQISVFSDLHFAEDASSIGPEKDARTVKVMGDVIDAELPDLVVLNGDLINGESTFIHNSTVYIDQIVSPMVDRNMTWASTYGNHDHNRNLNGTAMLEREHTWPGSRTDSMVPGSDAGTTNYYLPVYASNCSSNCTPELILWFFDSRGGFYYQGGAQPNWVDKSVVEWFNETNADLREEYGKNIPSLAFVHIPVYASLMLQNNGIDENYHPGINDETVIQQGAGWCADKKGGCDYSDQDLPLMQALVATPGVIGLFSGHDHANSWCYKWEDKVGDMDLPGNGINLCYGQHTGYGGYGDWIRGGRQIVVTQEGLKNLEIDSHIRLESDEVVGSISLNSTYNTDAYAATPNQKTFLSIASSSTPTPSTRPVSLGARFGLPNAFNSSLIVFAGVITWIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ16</accession>
    <name>S0EQ16_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable ornithine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_14254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438161.1">
        <property type="nucleotide sequence ID" value="XM_023571095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ16"/>
    <dbReference type="STRING" id="1279085.S0EQ16"/>
    <dbReference type="GeneID" id="35407706"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14254"/>
    <dbReference type="HOGENOM" id="CLU_026444_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0702">S-nitrosylation</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="9">
        <location>
            <begin position="66"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT76115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="443" mass="48944" checksum="76A54EBC91B06382" modified="2013-09-18" version="1">MTSIQIGGPQGQHIGSIESSMTDRMAEYTMPTAEHLIRQALRKRIDSLDAKFVSHNQEDAFFVADLGEIFRQHLIWKQLLPCVKPFYEAVKCNPHPAVLELLYNLGTGFDCASRNEIEQILKLGADPKRIIYAHPCKALSYIHYAKAVGVERMTFDNADELYKIKDVFPSACLLLRISTDDSTSHSPLSKKFGADSATVGSLLAIAQELDLNIIGVSFHVGSGASDPMTFVNAVRDANRVFSQASAFGFNLSVLDVGGGFCKESFENMAWHLRHELDIYFPSSRGIEIIAEPGRYYVASAFTLATSVIARRITHGATYQQNGHMIYIQDGTYGNFSGVLIDHDLPIARILRSNGKILYGTRDANPLKSNDGVLYSIWGATCDGADCVVKTTRFKATIKIGDWLYFDNMGAYTSSSVTHFNGFPMSNDVVWVCSEASLPQYVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHI3</accession>
    <name>S0DHI3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423670.1">
        <property type="nucleotide sequence ID" value="XM_023573295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHI3"/>
    <dbReference type="GeneID" id="35395407"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01924"/>
    <dbReference type="HOGENOM" id="CLU_104707_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="163" mass="18247" checksum="03ACDCD056E097D9" modified="2013-09-18" version="1">MGSPAFALNPTGYMSIDTVEHARAVVTQCINGDLQLVPRGPDDREAAQFSWPPNAVFVFEVSDQVSRPPAYFDESEPEFFIRDIPGDTRVNLRHKSITIVENGRRYCVVVIFSSQTITNHYGHPRLQMLWPTELKLSEIHTPSQTCVAGLEAALQDMRDSGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHP1</accession>
    <name>S0DHP1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423601.1">
        <property type="nucleotide sequence ID" value="XM_023581227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHP1"/>
    <dbReference type="GeneID" id="35395485"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02002"/>
    <dbReference type="HOGENOM" id="CLU_073371_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="328" mass="38060" checksum="B4463DC2EB514E80" modified="2013-09-18" version="1">MDQDQRNRIENALLRYRKAVLEHNLSLLRILIEEVEAQPAPTGYRDSAAQHLRVEAIREQVVVPDSIKSTSEILDERFRDALISEGCLDGVSHGAVDLAGRREYFAGVQANIARKGVEVSEFPPADLEFLCSLVRGVTGPGLPFHREVSQFHFVTPLEFEEMEEMMKSVCIPIRDETGEEEYNSLTSIWEDWEISIAFKIGGGPRSWGGTYALYCRNDDHEQWKWRYGVHDEEWYSDVYESVEDYLEFYTHFREQTEEELREDIPSLEAMRIAQRYWLAIGSYRRTVSPERTLNRPMFSVFVNMVFHGVRYLIRSTLLPDHAVTPKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHZ6</accession>
    <name>S0DHZ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423732.1">
        <property type="nucleotide sequence ID" value="XM_023573884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHZ6"/>
    <dbReference type="STRING" id="1279085.S0DHZ6"/>
    <dbReference type="GeneID" id="35395356"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01873"/>
    <dbReference type="HOGENOM" id="CLU_022730_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="505" mass="55110" checksum="63E3CC2B36E9C9D8" modified="2013-09-18" version="1">MGSIISTLKSTASAISAGLKTVLTLHKQFSSLLERASSEPGFPVPQSTKSYWLDDPPFPALCDIRDDKLPSEVDIVVIGSGITGAAVTKSLLELSNSSLRVVVCEARQLCSGATGRNGGHIKSAPYDEFAMFKSKLGPENARRIVRFKRRHLEMMKQLGKGIEVAEVREVETVDVFVEREDFEKAKNQVEDVRAWMPEEKHRVWEAEEARKEFGLNELVVGAVTYTAGALWPYRLVTSVWNDLLERFSGLSINTHTPVEKVSHNPDGSYTVTTPRGVIKAKHVIHTTNAHAGQLLPPVRGCVVGAIAHMSAQRPGSSFPPTQGNRSWSVIYSPGFDYITQRPDRPDGTPGDLMIGGGFFRSKEDGLDQVGIWDDSKNHALPLMHIRGVMPSVYEPNWGTGSSLIKAWTGIIGFTGDLMPLVGRAPGSKGSGEWMAAGFCGEGMVYAWLCGTALAVMVLGKEGEKLGEGVGRPGGRLEEWFPGDLLGVDKERLRRAYIANAAEFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIK2</accession>
    <name>S0DIK2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424052.1">
        <property type="nucleotide sequence ID" value="XM_023577750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIK2"/>
    <dbReference type="STRING" id="1279085.S0DIK2"/>
    <dbReference type="GeneID" id="35395009"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01524"/>
    <dbReference type="HOGENOM" id="CLU_017554_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT61971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="410" mass="46056" checksum="57E0C518A1D81438" modified="2013-09-18" version="1">MSTKYAFLSLPQGVFDSSDRDDAISSLRGTISSDNGSVLPFNIPDFKIGTLDALVQQADELTKLEASCQAVVSKVADSLKNVLEGDEDRIAQYKMVNDKPTDQYVSTFSWNKIRYRADKSLAELISTLQKARSSTNRSPKLQLTCHQELANVDTDVKTKFNQYNSVKTNLAALQRRQTGNLSTKSLTPIVDPKLLVQDSEYIETHLIVVPGNAKKDFIKEYETISPMVVPRSAIEVAKDDEFVLFAVATFKKHSAEFLAKCREQKWTPRQYKYVEGGRQEEQRELDRVTNEERKVCGEALRMGRTGWSESVMIWIHVMTLRVFVEAVLRYGLPLDYVSVLVKTTSKLAPKVKAALDSNYSFLGGNAFGRDKRGKITKDDAALSSEMAAAGFQTGEGHEYTAYVYYEIEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIX6</accession>
    <name>S0DIX6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_00990</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424540.1">
        <property type="nucleotide sequence ID" value="XM_023568919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIX6"/>
    <dbReference type="STRING" id="1279085.S0DIX6"/>
    <dbReference type="GeneID" id="35394475"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00990"/>
    <dbReference type="HOGENOM" id="CLU_000288_52_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904828">
        <property type="term" value="P:positive regulation of hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901494">
        <property type="term" value="P:regulation of cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047484">
        <property type="term" value="P:regulation of response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090153">
        <property type="term" value="P:regulation of sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05586">
        <property type="entry name" value="STKc_Sck1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="284"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="489"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="751"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="349"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="841"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT62459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="893" mass="98406" checksum="4184223853D774CE" modified="2013-09-18" version="1">MHGVINKNVRSAADEDGADHIGLETPRSGVATPQPDLQDKRLPGIMSYFGQVRKYPSTPLSDPNSSQSDTTLDRIPVVPTPPAGLQLQAHTEGSPRRCEYSALDRSLLQHERPGSMPSTTQRDEHNLSDPYPTPPTSQPSSSGGSISQDMISVDSGVHGRAAVEQKSLTQQSQFKKPTASPFTTTHFQTSNDPSLPELDSSKNAAPAKDSIIPSHPEPSTSSGACSAAAPGKWHFLNGLKELTRMTFKSGNSTPTRAMSAARPSGSDRAPSSGRTSHDGAEVSGTQTPRSSAGAQAPAAKGKLTIKINEARGLRKSRDPYVVVVFQRSELISGGPHHIDEDDNLSVEPPPAAGGIPIQRSGSDSGRPLAIPMRSRQSSNTSINDYGSFRNRSGGQLTFTNPKWDAEAEFDVVDYDMLVDVSVYDHGATGDEFLGHVDFQASKDPGATVQGWFQLQGHADTMAENAPTGEIFLEAIYHRAERKQFGPTDFEILKLIGKGTFGQVYQVRKKDTQRIYAMKVLQKKVIVQKKEVAHTVGERNILVRTAMSDSPFIVGLKFSFQTPSELYLVTDYMSGGELFWHLQKEGRFDEKRAKFYIAELILAIQHLHHNDIVYRDLKPENILLDANGHIALCDFGLSKANLTKNDTTNTFCGTTEYLAPEVLLDESGYTKMVDFWSLGVLVFEMCCGWSPFYAEDTQQMYKNIAFGKVRFPRDTLSQEGRNFVKGLLNRNPKHRLGATDDAEELKRHPFFADVDWTLLSKKLITPPFKPKLKSETDVSYFDPEFTTALDQNGSLNERAAALARGYAASTPLSPSVQANFQGFTFVDESALDDHMRDRAGLVDEDMDDGQHHRNRDNDDWDNLDDIDLRKANRMSGIMKTGHDEHMVGGSHFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ17</accession>
    <name>S0DJ17_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to CAF120 CCR4 Associated Factor 120 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424575.1">
        <property type="nucleotide sequence ID" value="XM_023569352.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DJ17"/>
    <dbReference type="GeneID" id="35394436"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00951"/>
    <dbReference type="HOGENOM" id="CLU_005248_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000203">
        <property type="entry name" value="PH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="24"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1301" mass="140833" checksum="0B97BC33447224C4" modified="2013-09-18" version="1">MDITEDTIPELQPIFSFLNSHSNKLYQEGYFLKLDDQNTQGKPNPDRTWTECFAQLVGTVLSLWDAAELDAAGEDGEVLPKFINLTDASIKMVNNSLACQIESLPTRSSDEQPLQNILSISTAGRNRYLLHFNSRHSLLQWTAGIRLAIFEHSSLQEAYTGALIAGKGKSLNNIGVIMERARFPTEEWVRVRFGAGVPWRRCWCVITPPDEKQYAKLQKELKKRSPYDRSPVPTLKGDIKFYDQRKDGKKQKKMQPIATITDAYSAYAIYPQSKSLIDASTLLKVEGNIAIHTDPPSSTEGFVFIMPETHPAVSGFEMLLRFLFPTWDTFGLYGRPGRLVASTLDSRSLMFAMPKSRRYGYLENLDVSNLILEDGSSGWGERDWRKKLKECTGTRMNAVDDAPTTRSRSNSRKSVRLSFGDGPPKPKAGFSDEQVPTRSSRSFSLTERTRTDSAPADPARVAFGGHGRNSSDPNQLGGPPFRPGTNGNSPYSGSPQRGQTPVGASRHNQASRDESPAYQNERAPSGSPPLKDLDGMRQMHTPEPVSRPPAFSHGSQARPVSRAYHSPELRRANSRLSVTTLAQLATAGGLGGPNDSNPSPRGDEVDTARSGPSVLPPHANSVGISANDNRSREALSPLNQDPSSNSLPPLANLSQQRSRSPLAQPPLGPPNAYGRGPNSRPGTSEGRRSPMPPGMPPQQRPPHPQNANRRPDMGPDGRRPSDPRRPGPDGRRPSDPRGPGFDGRRPSDPRGRGNGPPPGHMPPPPGPHGNYRPGPGRPGPPGPPGYRPNGPPHGPPNGPPGPMGHRKPVPGGPPPPAPFENSKGNTMSGSSGITTNEIIDHYAFDQGRHTPRQGTPNSERRPGPPGRQESHQSNQSSHYEDNSPTSSLKNFVDTYQYSEPKPRAGVLKTVGGAEEPDPRDPGFDIPDINFGPTINYAATKDRSKNPGALTPGGSSQRPHTPGGQGPTPPPHKSSGSQGSLGRKESPDPKRTMAWQPGASTPPSNAHGLSPEEFVQQRAAHARSASSNTLGGSPSSGMKRTSSSDMLQAIQNGRHSRSSSADMLARPGSRGASSTLNFASSGETSSHLSAREQEHVARLTGQPLISMPGHQRQGSQGSFMPGHQRQASSGSGLVGAIEAREREKQQMKQGVNSQAVQHAISQRQQQQAAMAYQQQMAQQQMAQQQMMQQQMAQQQQIAYQQQAHQQQNYQQGYQQPMMGAGNIPPYSPMGQPAGQYTPGGSPYGPAPQQMGGHGQANSFSRPLRAAQQVDPRFVPPQGQYGPSPGAQPTTRNVHPQYQGQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJU7</accession>
    <name>S0DJU7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to sorbitol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424726.1">
        <property type="nucleotide sequence ID" value="XM_023571197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJU7"/>
    <dbReference type="STRING" id="1279085.S0DJU7"/>
    <dbReference type="GeneID" id="35394270"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00785"/>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="126"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT62645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="653" mass="73495" checksum="87F7C3A4F9D2B2D1" modified="2013-09-18" version="1">MAPNRGGDDIERLSRTTNEYPSSSMIEHARRPSEAYVNLHANIEAKIKNPLWGLPRARLLADVDDFCRKKELEQYRPLIRKGALVAQDPTGYEDIDGDEKLDDTEIQALRDEILHKWRVPFVLYLTVATCSIGAAVQGWDQTGSNGANLEFPYAFSIGSESIHDKLLVGLVNSAPYIGTALFGCWLSDPLNSRWGRRGTIFFSANFCLWPVIGSAFCNTWRQLFACRVLLGIGMGTKASTVPIFAAENSPAPIRGAFVMSWQMWTAFGIFLGTCANVAVTKIGHNAWRFQLGSAFIPAVPLMCLIYFCPESPRWYMKKNRYQDAMKSLLRLRNHPIQAARDLYYIHAQLEVELDFIGEAHYAKRFIELFTIPRVRRATVASFVVMIAQQMCGINIIAFYSTSVFRDAGADDNQALLASMGFGLVNFVFAWPAIWTIDTFGRRSLLLFTFPQMAWTLLAAGLCTLIPGTGGAHMALVAFFVYLFAAFYSPGEGPVPFTYSAEVFPLSHREVGMSWAVATCLFWAAVLSITFPLMLARLHAIGAFGMYAGFNIVALVMIFLLLPETKQRTLEELDYIFAVPTRVFVRYQVTKVLPWWIRRWILFQREARLEPLYQFDTVGEPEDNHSSDFGYENDKAKVELKDTIGLTSGVQTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKT4</accession>
    <name>S0DKT4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to deoxyribose-phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425305.1">
        <property type="nucleotide sequence ID" value="XM_023573612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKT4"/>
    <dbReference type="STRING" id="1279085.S0DKT4"/>
    <dbReference type="GeneID" id="35393637"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00152"/>
    <dbReference type="HOGENOM" id="CLU_053595_0_2_1"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="238" mass="25599" checksum="6C9A703E637EF0A5" modified="2013-09-18" version="1">MSSNTNQITVTLRQIAKMIDHSLLHPTMTDADILQGLAIAKKYGVATACVKPYAISMAKQELQGSDVLICPVIGFPHGNSSTSVKLFEADVATTVGGNEIDMVINIGKALGSDWNYVADEIRQVNNVVVKRGAILKIIFENDYLDEEQIQSDGTYNYKGATIPHLKLMVEESGKNVQVKAAGGVRTLDDLLHVMSLGVTRIGATATVAIMEEAVKRGITDEPTEVTFNPMADSSIGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKW3</accession>
    <name>S0DKW3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_01484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424088.1">
        <property type="nucleotide sequence ID" value="XM_023578195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKW3"/>
    <dbReference type="STRING" id="1279085.S0DKW3"/>
    <dbReference type="GeneID" id="35394969"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01484"/>
    <dbReference type="HOGENOM" id="CLU_034027_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="255" mass="29871" checksum="3BF1808301CEFB3D" modified="2013-09-18" version="1">MDDYVSESDSDYTSYWRDWFISSRGNEYFCEIDEDYLTDRFNLTGLNTEVQYYQYALDLVTDVFDLECDDEMREAIEKSARHLYGLVHARYIVTTRGLTKMLDKYKKAEFGKCPRVMCHSHPLLPMGLSDVPNMKPVKLYCARCEDIYNPKSSRHAAIDGAYFGTSFHNILFQVYPALIPTKSVERYVPRVYGFKVHASAALIRWQSAKRDEMRRRLRKLEIDTGFRDEMEDEEDDDEELEFEGIDGRMAVVEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL30</accession>
    <name>S0DL30_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425192.1">
        <property type="nucleotide sequence ID" value="XM_023573478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL30"/>
    <dbReference type="GeneID" id="35393757"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00272"/>
    <dbReference type="HOGENOM" id="CLU_900275_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33776" checksum="E56F46FBFB3CF2A1" modified="2013-09-18" version="1">MSGEIRTIARALRAAGHNTLPNGDLTFLQVQGRRLIERVYDGDELKDQRMVASGLREGSTADYAVAKDRTFAVYISDDGLIKVSEFDEDSEEWDEAHLEGLGDVSVHDESHITVAGLPSMNLVLYQAHDGTIKTVKHDKDSDIWTEEFDIPGSAATGTPIAGFTTDEALIVSFFGDDGEIHVHSRDFENGEWTEETIPDSSFDDTVNSIIVAKDKDSGNFEAYVLANDTVYNITKTGSRDTVGSFDQNGDFEPSTKAESGGCYSNNWGNYCGSYTCYRGCSCGCGQGYMCGCYSCGCGCPRPRRCPPCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLN4</accession>
    <name>S0DLN4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_01387</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425600.1">
        <property type="nucleotide sequence ID" value="XM_023579295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLN4"/>
    <dbReference type="STRING" id="1279085.S0DLN4"/>
    <dbReference type="GeneID" id="35394872"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01387"/>
    <dbReference type="HOGENOM" id="CLU_171977_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT63519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="66" mass="7749" checksum="14D7CA011A076B47" modified="2013-09-18" version="1">MALANTLYRSLFSTNYLMLATVFTAGFAWEIGFNNVMDKVWDNNNRGRQWKDIRHKFLEGGDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLQ8</accession>
    <name>S0DLQ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to KEL2-involved in cell fusion and morphogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425457.1">
        <property type="nucleotide sequence ID" value="XM_023573131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLQ8"/>
    <dbReference type="STRING" id="1279085.S0DLQ8"/>
    <dbReference type="GeneID" id="35394069"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00584"/>
    <dbReference type="HOGENOM" id="CLU_019536_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Attractin/MKLN-like beta-propeller" evidence="4">
        <location>
            <begin position="354"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="507" mass="55551" checksum="88B922DB5979F205" modified="2013-09-18" version="1">MADPRRSPDKSHLKAKSIQQQQQRSPAPAPAPTTTRPTFVDDDSDDDDESSDQMPLPRSHTPGHLASKSIQANRRKPSDLSIRQRSQSASQTAPQGASTSRPAHKPPHSISTSAGDASSEGDRHNRRPTASRSTSAITSRTTAQATARYASHRSRISQDEYTAFPSLPDPRTAPKVDVAPASGMYWSKAPVSGAPHTSLRAHTTTIIGSNVYVFGGCDSRTCFNDLYVLDADSFHWSIPYVVGDIPVPLRAMTCTAVGKKLIVFGGGDGPEYYNDVYVLDTTNFRWTKPRIIGDKMPSKRRAHTACLYKNGIYVFGGGDGVRALNDIWRLDVADVNKMSWRLVSSSDKSSPGSKDYRPKARGYHTANMVGSKLIIFGGSDGGECFDDVWVYDVDAQLWRAVPIPVAFRRLSHTATIVGSYLFVIGGHDGSEYSNDVLLLNLVTMTWDRRRVYGKAPSGRGYHGTVLYDSRLIVIGGFDGSEVYGDVMLLELAVHAYYSQISHFTIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLT7</accession>
    <name>S0DLT7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_01427</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425487.1">
        <property type="nucleotide sequence ID" value="XM_023578828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLT7"/>
    <dbReference type="STRING" id="1279085.S0DLT7"/>
    <dbReference type="GeneID" id="35394912"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01427"/>
    <dbReference type="HOGENOM" id="CLU_008917_4_1_1"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494960" description="Mannosyltransferase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT63406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="552" mass="60072" checksum="DA553F32A3D56B55" modified="2013-09-18" version="1">MKTSDIFLTCLLITIPLVHLLVSPYTKVEESFNIQAAHDILIYGTPTRDVYERLSHTYDHFTFPGAVPRTFLGAVLLAGLGQPIVALVGFQHAQLIVRGILGAANVAALLTFKSSLKRAYGSGVSAWWVVFMASQFHINYYVSRTLPNMYAFCLTTLASAFLLPQPSPHLSAARQKQAIALLVIAAAIFRSEVAVLLSTTGLYLLFTGRIGLRPLILTFLGSFISSLLISVPIDSYFWQKPLWPELWGFYFNAILGSSSEWGVSPWHYYFTSALPKLLLNPSVPALAVYALLQPGTSRATQTLLIPNLLFVAIYSAQPHKEARFIFYVVPSLTAAAALGANFVSSRASKSIIYRGVSAAIALSVLVSFAGSTVMLLFSSLNYPGGDALQQLSYITRDDPTPVIDVHADVLSCMTGLTLFGQNPSGCPIAFPISPNPDFAAPVLVFDKTEKGDQLYWPRFWERFDYALAENPRKVLGGWQVIGVVAGYDGVEILKPGSPAAGDESEEGTIGGDKILGLGANVAAVRNLVRGYTGGWWVGPRMSPRIRILRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLV9</accession>
    <name>S0DLV9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to hsp70 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423604.1">
        <property type="nucleotide sequence ID" value="XM_023581672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLV9"/>
    <dbReference type="STRING" id="1279085.S0DLV9"/>
    <dbReference type="GeneID" id="35395481"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01998"/>
    <dbReference type="HOGENOM" id="CLU_009958_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF8">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G13740)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="712" mass="81348" checksum="0FFC2DC0EC730D7D" modified="2013-09-18" version="1">MSFSRSSTVTLGRENAPNHQHQPEEDHSRPEPINLDLLDEDRGDPFPKRLIIAVDFGTTYSAVSYVDVPQGCPSDSVDSRSIRSIGNYPENYNYHYNDPMGLEVPTEVIYPLDRHFRDHFNLDNPEEPSENGDRVAVQAPDEDGDISMLSDMSEEFRWGYRVHEVWNRPSTHSNTTNQPMSRFKLLLDQSEMTESVRRNVRETIDTLKRRNVIQGPLHVIADFLTYLLEHTRSQLRRQGFDDSYEKEMILCVPAIWTQKACRDMQACLAAAMKRANFTRADLQNKSIDNLFIVSEPEAAAAHMLSTSAQIKSGDCFVLLDAGGGTVDANTYRVSSEEPLRLETEIVAPGGGLHGSSYLNEGFREYLEDLLAEETYLNDGTETIHGIVERITFEEFEKRIKRGFDYRQQRPRKEIYIKGLRDNPAKGFRNECIYVPKQKIQEIFFRHLDAIVEIVKSQLEEARGKGYTVGKVVLIGGFGTSISLSQRLKEFLEEYGREHNCRVTLMEPQQGTSIINAVASGAVLRALNKANGPERIARSSYGIMRSEPFELYDEHKGLTPSYDNHDGMAYIKRTIDWVLKLGEVVPSVWQCEPFTCSHTFDVWPVRPFICKEVLYVSDRATKSHYRKTHPNNEGAECVGEIEVDFSSLRDRLVPIEPGFNKNQRKVGKRHYRIDFTMVIKVVDRDLECFAIHDQKVVKKCRINIASGFRPGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM87</accession>
    <name>S0DM87_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425825.1">
        <property type="nucleotide sequence ID" value="XM_023571536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM87"/>
    <dbReference type="GeneID" id="35398580"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05099"/>
    <dbReference type="HOGENOM" id="CLU_024882_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="77302" checksum="ACE2F87EB4114291" modified="2013-09-18" version="1">MALPTMNGDQGPTSEQGSWDLLSSRSDELSSGSYDFNGVGTAFGDLDSRPSDMSLALSANSDEVSLRFEEQDYLIKSKLASVETQLDYMSDTANFPNLSAEEIMSQREAREQARADLVRLKEENRLNRIRYDELRDEIIGSTDGNLTPTQVLAKMEELGRVEVDLLESNMALREMNQAQGDSSSRSDFARSDGNSAADGGNNDASPTNQGLASDDQDAPTSNQNETVSIRSDDEIYMININSVFDPDSPADSRRVLLEKIPQGTTLTQIANAVCGIGGLVRISLMHNLVNSGTAFKVACVEFRDSAAARKYVANVKANGLELVDGTGRFFEIEVKLINSTSSYDSRHGHPLEYGVGYHTEHSGRCITLENFPTSAIWHLLTRFGTKYIIRASFSPNDNQMNGKLSIEFASVFEAGRLCYMILNHVFLPYHGPASKMGFGPTPSDRDVVELTNSVSNTIAHVPPKHLSDAWNVQPFNLFTPSLNFAYGTPIPRRAVTSRTSSMNVEVVSRTPSMNIEVPHTPSTNAEASSRPSINVETLHRPSCYPGNYAVVPHILVRDDKNSPDLRDIQMTNITFNFVDGNTKYIIVKGKIFSRQVNGDIYTKLDDTELMKLKQDNVLKTNWAPFWRHYCEANEMPYLPKYAEYGRVASVRRNINKKFGFASSWNPERLTAIPNQIKAYLNPKSRKVVSTAEAEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMS9</accession>
    <name>S0DMS9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent protein kinase regulator pho80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423944.1">
        <property type="nucleotide sequence ID" value="XM_023576417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMS9"/>
    <dbReference type="STRING" id="1279085.S0DMS9"/>
    <dbReference type="GeneID" id="35395129"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01644"/>
    <dbReference type="HOGENOM" id="CLU_071095_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494979" description="Cyclin-dependent protein kinase regulator pho80" evidence="1">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20340" checksum="E30257EE0BF896D3" modified="2013-09-18" version="1">MRITTFLSTICAAALVAAEQRTAQVYIQPILSSPSTPQILAEVAYDAASLISTEIVSYEAPELPESASLVRVGIYDPKSSRWIAGTTAASTENFDRGYAPTMLLSVDESGDVRSVALKGVRVDAGQTRDFGPKAVVIAEKKGAQPELNKPVVLSPNGKKAAEEEPKSLLQKYWWLIAIVVVMSMAGGNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP35</accession>
    <name>S0DP35_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04613</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426271.1">
        <property type="nucleotide sequence ID" value="XM_023572080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP35"/>
    <dbReference type="STRING" id="1279085.S0DP35"/>
    <dbReference type="GeneID" id="35398094"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04613"/>
    <dbReference type="HOGENOM" id="CLU_020931_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT64190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="538" mass="59267" checksum="75E446B9481A9EC2" modified="2013-09-18" version="1">MSPHSEVSFNGFETPVSNGTTNGHNGTNGANGTTNGHNGHVNGNSNGNGAAPAARHGPRVHKERSPYLESAPADSEFDLICAGFGPASLAVAVAIHDAIAEGKKLRPDGAAPKVLFLEKQTKFAWHAGMLLPGAKMQISFIKDLATLRNPRSEFTFLNYLHRQGRLVDFTNLSTFLPARTEYEDYLRWCSSWFDHVVSYSNEVLSISPESKEADAVKTFTVQARNGKTGQVQSFRSRHVLVAAGGQPSLPKSLPAKHPRVLHSSQFANYAPQILAKQNAPYRVAVIGAGQSAAEIFNNVQNLYPNSKTYLIMRQEFLRPSDDSPFVNSIFNPEYIDNLWPRSVKARETLLTEARATNYGVVRLELIEHLFEKMYDQKREISDDETQWPHRILAGREIASVDTKGDALEIKVQRVNDGPLDGFVDQETFEVDLIVAATGYKRSAHVDMLKDAWTMLPKTVSGRNESPKGVNGWNVETQDGERKLAVGRDYRVKFSPGTVADDSGVWLQGCCEGTHGLSDTLLSVLGTRSGEIVESIFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP67</accession>
    <name>S0DP67_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426445.1">
        <property type="nucleotide sequence ID" value="XM_023572295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP67"/>
    <dbReference type="STRING" id="1279085.S0DP67"/>
    <dbReference type="GeneID" id="35397902"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04421"/>
    <dbReference type="HOGENOM" id="CLU_060196_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="258" mass="27778" checksum="43848626370FA9EF" modified="2013-09-18" version="1">MSALRILVPVKRVIDYAVKPRVNKAQTAVETAGVKHSMNPFDELSVEESVRIREKKRSPGGVEDICVISAGPPKAQDVLRTAMAMGADRGIHVELKDGDELEPLTVAKILQKAVEQQKSNLVILGKQSIDDDAAQTGQMLAGLLGWPQATQASKIEFGAGDKVTVTKEVDGGVETVSAKLPMVITTDLRLNEPRYASLPNIMKAKKKKLEKTKLEDFGVDGVKRLKTLKVIEPPARQGGGKVEDVGGLVSKLKELGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP70</accession>
    <name>S0DP70_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426312.1">
        <property type="nucleotide sequence ID" value="XM_023572127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP70"/>
    <dbReference type="STRING" id="1279085.S0DP70"/>
    <dbReference type="GeneID" id="35398052"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04571"/>
    <dbReference type="HOGENOM" id="CLU_003661_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="780"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="715"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="784"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="842"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="857"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="927"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="943"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="988" mass="111018" checksum="4ADCA7D4EDF1EAB2" modified="2013-09-18" version="1">MISVPLKATNEIDWIEPLKGYIRDTYGDDPERYAEECATLNRLRQDVRGAGKDSTSGRDMLYRYYGQLELLDLRFPVDEQHIKISFTWFDAFTHKSTAQYSLAFEKASIIFNISAVLSCHAAAQDRAEESALKTAYHNFQASAGMFTYINENFLHAPSSDLSRETVKALIHIMLAQAQEVFLEKQIADKKKIGLLAKLAAQAGYLYGQALEGVQENVNKAIFEKVWLLMIQIKTNLLNSMAQYYQALADDEANQHGIAAGRLQVAEAQAKEAERIARNFPSSVPMSSNLSADCGGFLQEITKRHHSTVQTQLQSALRDNDYVYHQEVPAEASLEAVAKLPAAKPIPVSELYAGQDIQRITGPDLFAKIVPFAVTESASLYDEEKAKLVRAEAERVETANDEMAASLDYLRLPGALQVLKGGFDQDTLPDEDFRQWCADVSDQDNPVTLFDSLRSEKDSILMILDKSTKQLDMEEGVCEKMRSKYENDWTQQPSSRLTTTLRGDIRHYREALDEASRSDNQLAGKLRQNEMDFDEMRRAAQSGEVDQLFQRAVAQARARGSNATSPAGIEPNLLDDDFEEGPSVVDQINRVEDILKKLNLIKRERNQVLKDLKEKAHNDDISQILILNKKSISNYETQLFEQELEKFRPHQNRLLQANHKQSALMKELTNTFNRLLQDKRVQSEQSKYEAIQRQRSSVINRYKRAYQEFLDLVAGLQSAKNWYAEMRETVESLEKNVDSFVNNRRSEGAQLLNQIEQERSSSKNSQAEMERERLRGLMDRMSIDPSKSSPQPQTQNRPAPPSQYQQGQNPRYPQTNYQGQYQAPNSPPVQKQTLAQQAYQNFSPPPTTQSFGPPPINTFVQPTYNPSQYGRTPGPTSPPPNQTSFNIGGYRGPASPPPNQTTFGQTQSFGGYGASATPQTQGGYVPPGFVPPPPPPGPPPLGPQQTFHYGNQPSSAHPNSAYPQSAHPQSAVPQQQQQNDPWAGLNAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ04</accession>
    <name>S0DQ04_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_14887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425573.1">
        <property type="nucleotide sequence ID" value="XM_023581194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ04"/>
    <dbReference type="STRING" id="1279085.S0DQ04"/>
    <dbReference type="GeneID" id="35408257"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14887"/>
    <dbReference type="HOGENOM" id="CLU_116866_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="WSC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT63492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="125" mass="13370" checksum="CDA2AD0FB313609E" modified="2013-09-18" version="1">MQIQDSAQERALTGGSHLVTAGKMTVPICLEFCASNGTQYKYAGLEWSRECWCAPYLSSLSVRLNDGECENSCEGNSSQVCGGPLKLSVYELAEGGDTPDGVAINQIPRGLFVLTIIFGMSLLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ33</accession>
    <name>S0DQ33_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to DUF255 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426607.1">
        <property type="nucleotide sequence ID" value="XM_023572493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ33"/>
    <dbReference type="STRING" id="1279085.S0DQ33"/>
    <dbReference type="GeneID" id="35397726"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04245"/>
    <dbReference type="HOGENOM" id="CLU_014051_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="1">
        <location>
            <begin position="36"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="720" mass="79531" checksum="F0D1C3C295F04116" modified="2013-09-18" version="1">MVASELTASAIAMRSTPVSGDESSSSLPKPLAPLRNRAAASQSPYIRGQAESLVSWQLLDDEAVERSRKENKLIFMHIGYKACHFCRLMSIETFSNPESASVLNESFIPVIVDREERPDLDAIYMNYVQAVSNVGGWPLNVFLTPNLEPVFGGTYWFGPAGRRHLSDDSTEEVLDSLTIFKKVRDIWIDQEARCRKEATEVVGQLKEFAAEGTLGTRSISAPSALGPAGWGAPAPSHAGAAKEKSTAVSEELDLDQLEEAYTHIAGTFDPVFGGFGLAPKFLTPPKLAFLLGLLKSPGAVQDVVGEAECKHATEIALDTMRHIRDGALHDHIGGTGFSRCSVTADWTIPNFEKLVTDNAQLLSLYIDAWKVSGGGEKDEFLDVVLELAEYLTSSPIVLPEGGFASSEAADSYYRQGDKEKREGAYYVWTRREFDSALDEIDSHMSPILASYWNVNQDGNVEEENDPNDDFIDQNILRAKSTIEQLSIQFSTPVEKVKEYIEQGRRALRKRREQERVRPELDDKIVVGWNGLVISALSKAASALRTLRPEQSSKCRAIAEQAAACIRERLWDGNERILYRIWSGGRGNTAFADDYAYMIQGLLDLLELTGNQEYLEFADILQQTQTSLFYDADGAFFSTQANSPYTILRLKDGMDTSLPSTNAVSVANLFRLANLRSNDDLAAKARQTINAFEVEVVQHPWLFPGLLQGVVTARLGGETSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQZ4</accession>
    <name>S0DQZ4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_03879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426942.1">
        <property type="nucleotide sequence ID" value="XM_023572900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQZ4"/>
    <dbReference type="STRING" id="1279085.S0DQZ4"/>
    <dbReference type="GeneID" id="35397360"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03879"/>
    <dbReference type="HOGENOM" id="CLU_301881_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="533"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="857"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="785"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="799"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT64861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="110189" checksum="89444B4614D2C9CC" modified="2013-09-18" version="1">MSTIADHVSACLQEFNSLCNSPAIWTDCALEEGHQSDISLLKLQNELSRFKVWSGNIGAHKKGRSSLDHRLRDASNIRNQVVDLLEDLRESLKDAKDILTGQTTPWDQEQSPAEFSDDDSDDGSFQDDAPGPSELSQIFAAIVEDINCLLRLSVSIHNPSPHDRFKKACLTDTSGYEPFDVQHVYNKLSKAPKPIAERLGKAISRRRQYFKYRELHHEKLASGLELDGKDQMQSTVASSLPKKLSLNEPISLEEDVDDASDGGRSQTSWATSAANPERRKIPALPAEAENGPFECPFCFIMVSITSRIHWKKHVFSDLFPYICVELGCPAPDQDFQRRHQWASHVKKYHWKTWACKLGCNETFVSIQDMKRHLAQRHSETMELTRPFSLLSMCERPKLENESADCPLCGEKQSSFKQFQRHVGRHQEDLALFALPHLPGGEDDKNEESGSESEADEDMEPEIRDELEQASSYITRLSDGSVEEATDVSERSIRFAQEGGFAPVAVKEEISDDSVPTFMARRKKNPPPEEIVPQKCHEPGCNKEFKRPRDLNKHKKTHSRPWKCPVPTCKYHTYGWVTEDDMDHHYREEHSETPAFYECVFKPYPYKSKRETNCKEHMEKAHGWDFIRTQKVILSTGRHSTVEPSRTPPDADSEDQSSEQGRDLTTQRSIEMLAPIENRESFDLANVDVLHLRHKESSYTFKFPRHDIRDGRLRVSKVRELAAGMTYVPESFRHLVELSCKDTKLLIDGTPIRNYGVSRGDTINVEAPQFRKSGLLIRSASDDLVLDNGHSTEENMGIEGKAERDERRAEFSSELRQRATVESGGDQRQKAPASSNPQDVREETNRNMRKIRKKTKTGCLTCRKRRIKCDEGRPTCNNCIKSERHCEGYNQRIIFKDPMGARQGVPAPEIESDLEIMDTREVSGPILLSKEADRKVKRTPTSGVRCPTCAVGNKEVWVLIGGSCAYCGTPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS41</accession>
    <name>S0DS41_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_02188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427336.1">
        <property type="nucleotide sequence ID" value="XM_023573889.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DS41"/>
    <dbReference type="GeneID" id="35395670"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02188"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_8_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="239"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="729"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="762"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="795"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="899"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="971"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1045"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1183"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT65255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1349" mass="150717" checksum="73C9A75B05F46CEC" modified="2013-09-18" version="1">MEVTGLAVGVVGLAGLFSVCLDSLSRFQTYRESNSETHILETRFRAARARFEQWGVSVGISNGRLQSDHHLGLDNEETTHLIESILQIIAKTICDESILQRTRTGPRFQSGQFGGLSQSRGKRLKWALGGKESRLEQVDMFEKLVQQLYNLIQPEDKNQSYEGLESTAWVEDIRQMLSKIEEGMKFEMQRDVLSWLGKSAPNDKYEDSLAKRVNTTCEWILERPTFQSWLSPVNSTEPHVLWINGPAGFGKTVLCAHIVHYLSEALDTPVAHFFFTSDHESREDPFSTLISWLRQVAAKMNDAFECIRRAFEHEYPSEQASRKTLLELLKQVITAVPGCVFIADGLDECSQLGNGDASVARFLRDIMVAIAGADARLLLVSRDEPDIREALTEHQEILSEYRIDTNDVQADIAVFSRSVVNRKLWGKSDDLRAAISKSMTDRCQGQFLWIKMQEESLRSGMSKKRLHEVVENMPSGLDHIYDQNWNRIMNMSDWDRDRAFALLRWTAFTFIPLTVYAAAEAVLITQFGDLDPDEYPENFDNVYVKTEIVGLCGPLLEIRDDPDDLSSQRRTLHIPHFSVHQYIVDHLPVPAWMQANRALDSENERAQHTAIAHVCVQYLTLSQVWEKGCYRYLCSGSLLFYASYFWLRHARIAFMDNSLVVLSKAFLSNESVQFKSFVNYLVEHQEIVTLKVETIEPCLRPLEHIFYEGWVKMADHLIGDRDVNEIGALGRSPIFSACYSGSVESVRMLIERGADLSITDSRGCTCLHAAVRCGFEDIVGILLESNIKLSPQDHQGCTPLHYAAGFGHINCYQILLEQGADINIRDTWGGNALHHACLYAGHAEILRFILQNAPNNFSTDHYGRLGSPLTLVSDCGDAAMAKVLFEHGAVSSLFDPSHNGDLPLRLAASSGHIELVKLFLDHGAERTLACPDRTGNTTLHLVCRVTGLEGIIRLLLLQPGIGNLMLLENEDGNTPVHVASEAGYALYVKLLLQYSESESHQHLLWKRNKKLETPLYVASSSGHANVVHELLNFGAQATFSVLDEMGQTPLFIASFNGHAEVVKVLLENGADPSIYALDSYNTNPLWAASFGGSCDTIKELLAHGAAKTITTTGQGGETPLHAAATENHVEALKLLLEVPGVSINQKTIYGFTPLFIAARNGYCDIVKLLLATDLVDINSKNWLGLTPLFAAVANGHFHVTKLLLLEGVYLHSEISIGRDLLWWAQRSGKVDLLQLLQTQENPICPHVEPCNPLPDPFLVLEPLSHDAGTIPCEPGMFWCHVCTLSVQNDQNFLCTECNDCYLFLCSECFTRGFRLCPRSHTLVPYESDSDESDMSVGADLSVGSKDLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS98</accession>
    <name>S0DS98_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427407.1">
        <property type="nucleotide sequence ID" value="XM_023573970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS98"/>
    <dbReference type="STRING" id="1279085.S0DS98"/>
    <dbReference type="GeneID" id="35395743"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02261"/>
    <dbReference type="HOGENOM" id="CLU_880139_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="253"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="316" mass="35585" checksum="90C743F16B3B803A" modified="2013-09-18" version="1">MFTCQLDSDYLVTCAWEKTTDVLNVFMKGPEDDQEVGEFKVFANTKPHDEASDEVAELKRKIKELTDNLTAEKVKTASLTAQLAQAQTTCQAEKTQKDNEITRLEDKVSQLERDKTTLQTKLDQALHGEGDQAHKDAKISEQAARIAELERKLQSRPEILFRTWLRSRITHGYSNGKEYLLQLTNAGNPEGKPPVSIREQNARYISPLWEIYAVDGSNDAVIIMSGSSGYVIWSKGHEKKAQASKHDLSDPAAHWVLEGMKRDSPSMNKVIKIRNVKDGTYLDVRNAHAADETPVITQNGNGGSSQKFEIYLTWQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSU7</accession>
    <name>S0DSU7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_05201</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425729.1">
        <property type="nucleotide sequence ID" value="XM_023571422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSU7"/>
    <dbReference type="STRING" id="1279085.S0DSU7"/>
    <dbReference type="GeneID" id="35398682"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05201"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="45"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT63648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="378" mass="41027" checksum="E9CAC4DDCD9A15ED" modified="2013-09-18" version="1">MLSRGSLRSAQLLRGVAKQQPQLARSFATVQSDIFKPAKYGGKYTVTLIPGDGIGTEVAESVKTVFKADNVPVEWEQIEVSGLEGAGRTEDAFRESVASLKRNKLGLKGILHTPISRSGHQSFNVAMRQELDIYASISLIKNIPGYETRHKDVDLCIIRENTEGEYSGLEHQSVDGVVESLKIITRAKSERIAKFAFSFALANGRSKVTCIHKANIMKLADGLFRSTFHQVAKDYPTLEVNDMIVDNASMQAVSRPQQFDVMVMPNLYGGILSNIGAALVGGPGIVPGCNMGREVAVFEPGCRHVGLDIKGKDQANPTAMLLSGSMLLRHLGLDEHANRVSKATYAVIAEGKVRTPDMGGSSTTHEFTKAILDKLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT81</accession>
    <name>S0DT81_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_05042</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425879.1">
        <property type="nucleotide sequence ID" value="XM_023571600.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DT81"/>
    <dbReference type="GeneID" id="35398523"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05042"/>
    <dbReference type="HOGENOM" id="CLU_000914_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="18">
        <location>
            <begin position="393"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="17">
        <location>
            <begin position="616"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="254"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="735"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="981"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1282"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1582"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1102"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="981"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1295"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT63798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1621" mass="178919" checksum="B5B230D00EAB7FD9" modified="2013-09-18" version="1">MDKNNPLDPDLNAASLADTDDSPAQAQAQAQEEPEPEPEPEQEQEPSVSSSVSASGEPSAADFSSSPRRFHPHSHPHSHPPSSSLTFGYVSVEQHNIQPNPPRQSRAFSSTSASLLANSSAAAITRKSRGAEPVTRDAHATARRASFTAAPSSTTAISSLPIRNPRPLARTRRESMNSDTASEEQTLADSQLSCPGEEPHQLRTRLPSANENSHTVSSEASNAASHRLSSSSDYQSRRLSGTSIYTLASARGVLSGSSSAHGSELGTPPRSVPGLLSTGKSTATGQSEAEVSSVTVTTSSNQPGQSVVGHPNQHHLTPRDLQSQPLDFTKRAIRHDNMQSSTSGLRQGPDRSRSRAKRRFSGSTATSSHSPSSDRGPHHREREEVKPSRFGVIGVCALDVKARSKPSRNILNRLIANREFDVVVFGDKVILDEEVENWPICDYLISFYSDGFPLDKAIAYVKARKPFCVNDVPMQQILWDRRLCLHLLDKIEVRTPKRVEVTRDGGPQYLTPEMVKHIKDVSGVSLDPIDPSQTPPPQKVELIEDGNTISVDGQTLRKPFVEKPTSGEDHNIIIYFPTEEGGGARKLFRKIGNKSSDYIKDLNVPRAITEPGSSYIYESFMQVDNAEDVKAYTVGPNYCHAETRKSPVVDGVVRRNTHGKELRYVTALGAEEKEMASRISTAFGQRVCGFDMLRASGKSYVIDVNGWSFVKDNDDYYDHCSNILKDLFIKEKMRKGGVTPPMPSPAPSDTDPFTRASNAFKDREQTQSGTNGVRTSINSIAGTTDSQPDDSSRRALSGTVTPILTPESGLPSKTHSTLATPAIPPTPVDVTLPGISSAPPTQQSAIAEPPSEQASIVPEPPLPTHSWKLKGMVSVIRHADRTPKQKYKFTFHSEPFIALLKGHQEEVLLIGEAALGSVVQAVDLAYEQGIEDRAKLRSLRNVLVKKGSWPGTKIQIKPMFRKKKTETPAISEELVAMTEEKKEITEEAGDSSKEDKSHQGPKRQDSLSGVTMSKFTAAEERLVLDKLQLIVKWGGEPTHSARYQSQELGENMRNDLMLLNRDILDEVHVFSSSERRVTTSAQIWAASFLGKKDIPEDFITIRKDLLDDSNAAKDEMDKVKKKLKGLLRKGNERPAQFTWPENMPEPSEVQTRVVQLMNFHRRVMDHNYKKLQSGAVTSLNAISNPSTEKLSGENSSSSIASSLSQANTLNQIQSRWCCGEDAELFRERWEKLFQEFCDGEKVDPSKISELYDTMKFDALHNRQFLEWVYTPPNHMLDEYTAAGASSVPGGSNGTKDGKSKESEDGKTSDDKSDKSHQPSPEGADKVDAGSRSASVKKLFRRRSFLNNLRHFNEEAPPEQYFRLYKGTKQTSSTADAHNEPLQELYRLAKVLFDFICPQEYGISDSEKLEIGLLTSLPLLKEIVQDLEEMQASDDAKSFFYFTKESHIYTLLNCIIEGGVETKIKRSTIPELDYLSQICFELYEAEMKSGDGTSPYDAPTFTYSIRITISPGCHVFDPLHVQLDSRHCIGCAPRRSLTPHADWLQVIKTLRAKFNQVKLPKTFLAVNLSDAFTFEDLERQGSDSDVLEMKTAPSRGITEQPKSPGDEGSETLATGAGEVMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTX5</accession>
    <name>S0DTX5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to transcription activator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_03889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426933.1">
        <property type="nucleotide sequence ID" value="XM_023572889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTX5"/>
    <dbReference type="STRING" id="1279085.S0DTX5"/>
    <dbReference type="GeneID" id="35397370"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03889"/>
    <dbReference type="HOGENOM" id="CLU_006173_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF4">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
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            <begin position="68"/>
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            <end position="882"/>
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            <begin position="971"/>
            <end position="993"/>
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            <begin position="87"/>
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            <end position="140"/>
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            <end position="857"/>
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            <begin position="982"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT64852.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1013" mass="111935" checksum="9742A9FA1BD122BB" modified="2013-09-18" version="1">MMEAVSQRNLNSSIANFSTTTPLSLTSQPGSGPLYWPFDARSYPALAWAPDTFAYSCNPALAAVKAPATATSTKPTGRRPRQPAAISRCTARTKASTASCTSASNKSASSSATSSARSSPASSRGISPRIKSKMPGRPPKRAASNGEDDGTIQAPSKVKLPRLERGPDDFSSVVKNRLQSYTRTGQACDRCKVRKIRCDALPEGCSHCTNQNLECYVTDRVTGRTERRGYMQELEREKSDMLSHIRDLEKLLDNKGVEVKPWEWSPYAQCPPDSNFDDLGNPIPDPKTGETWSQVGSAVFKDSGSAPSLSPSFPRTLESRAHENHLGVGMDSAPLSSIGGTRLSILGMTVDLASFEPPDAEEPPVDGKVAPSYDKSPQSFLQSIMRVNPPMQAEMPSREDAFTWAEWYFMTFSAFLPVLHKPSFMRLLTRIYDEPNFEPSVAELVTVHMVFAIICFQYGTRNWQQVDQRAQMNERSNSHYHFALSKFFELTCTRDLASVQAMAMVVKHTRAFPKPGVVSIVANLALQRALELNLHRESRKPGEPNSLQHELRKRAFWVIMTVYIAVTGRRGRPMPITVEEFDVGFPEPIADELLSDEGVDTSRDIPCPYWPGIASFKIIPIYMEMYSNIYSVRRDARNYVSIVRALEAQIKKWEDELPSHMVIDHAEQTEQTRLAAVYAKTWALEFRLCLRHPSVAMTSDKAMMAENMAICEDVSRQMLHCQMEIQKCKCLDTTWYQTSMYTAGTFTMLAAMWERRFETTPEAIATLREEMNGWIGILEEVGSLLGSDSSIATEIGNIIDRTISWIDHDMRNKETKSAQPSTTPEVKQEPTPSYPSSQVQSTPTSGGAQSEVPSTKSYFPESDLNGQTPYPTLAYNDHPQNNMAAPTYDTGAMFYNTSAQATVAATTSALPSSVAQVNPMLAFSQPPQVAPQPDMMWQSRGNTWHDWTSAIADTQDRFSASTLLTLGGSTRDASTGAGIPGVTSSPSANDINSIQQGGQWPLIIFDQVGPNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTY5</accession>
    <name>S0DTY5_GIBF5</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT64862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023572901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTY5"/>
    <dbReference type="GeneID" id="35397359"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03878"/>
    <dbReference type="HOGENOM" id="CLU_1970738_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT64862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="127" mass="14370" checksum="0B3A93A6556658C8" modified="2013-09-18" version="1">MISTPEPPSSRQTETVEPLLDPGLMMNQNELKVWNALCELEDELEVGWLPICKDSINLDDGSAKRQEERLGLINGIHSNIIKKLRRIEQLSGPDIKAKRSHVEEKVDKLLATFGAKSMTGTEKYWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUJ1</accession>
    <name>S0DUJ1_GIBF5</name>
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        <submittedName>
            <fullName evidence="9">Related to myosin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
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        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCT64223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023572119.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="35398060"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04579"/>
    <dbReference type="HOGENOM" id="CLU_001250_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="7">
        <location>
            <begin position="184"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="8">
        <location>
            <begin position="482"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1065"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="1201"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="1535"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1849"/>
            <end position="2072"/>
        </location>
    </feature>
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        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="164"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="298"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="568"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1237"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1437"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1502"/>
            <end position="1526"/>
        </location>
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        <location>
            <begin position="1548"/>
            <end position="1568"/>
        </location>
    </feature>
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        <location>
            <begin position="1569"/>
            <end position="1579"/>
        </location>
    </feature>
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        <location>
            <begin position="1581"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1612"/>
            <end position="1675"/>
        </location>
    </feature>
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        <location>
            <begin position="1716"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1849"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1878"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1924"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2019"/>
            <end position="2040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2072" mass="233483" checksum="39DD97C67CCA0934" modified="2013-09-18" version="1">MAAADVDIGYVAGHLGLDQPVIASLTTEPTVELVNIVLQAVAAKAHEFDTLYAEKLQTDIELENAVRSSETRSQTFKATADKALKDVEEARQQLKDEETKRQSLENELQVFKSKKSDYDAEIKALNDKIETLQSSNRTNLSIIESNNKRDQTITEELTKQHQRNVELSREITALQQSEQNARGQLNSAKYREESLQQQLDLARKNSEWLENELKTKSEEGLKYRKEKGARIAELQRQNEDIQSQVDSLKRTEQQLRDRLDAMQAKADDALVKVQNQEGTFAQTIESYKHELEAQKRLVEMSNQLSKKHQERVHDLEREKERLRDNYETELRRVRAELEQERQTTSEMEERINQLQSEVDELQARMEQHAPPPESAPETPRANGSLMRPSSPFATPSMRTKGAITTTQALDQLYQVKGQLATEKRRNAQLSEELDNMMTALEAKAPEIQDLQTEAEQLREEITRMSELSQNSFEERDKAKRAARKAESALATSQSETNILRTQLRDLGTQINMLLFQIHAMEKGTDRLTDEETFRLQQLQKGEISEEALSDMSDTHQFITQKLVVFKDIQSLQAKNEELLRITRELANQLESEEALAEKHQAKQDHDMVEKLQQELSHMTEEARSIKKTMESFKTERDMFRRLLQQRGVHGDEASMMRNSIAGGERLPLASIEATEQTEALNEALRKLQSEYDNYREAQDGVRKDLRDQMDALSAERNSLQTDKVKLHAEVRLESERREMLQTNYVALQSENRELQKRAQTLSETAAKQDIRTQQVAEELIEARGLLDSVRNETANLKAEKKLWKDIQDRLSKDNESLIEEKNRLNNLLATQQSIENERNMADSEARRKAQAKIESLEQELSDAQRKLTYEAEETKKLQLRKEFESKESQKRIDELMASLSQIREEHVAVKTSRDHLQARVDELMVELRNAEERAGRLQPRPTPRPGTIEVSEQQQQLENEIQDLNVEISDLKRNLDMANTYLENAKTQAEQFKELSQANEEALEDLRGSQEQYRQEMEAIIEEKDGKIKELSQRAEDLSAELSRSNTELSSLRDSQGEVARRYEDEKSILQEEVNRLKEESARHLEATRFHQQDLRAQAEIASKAQQDYEQELVKHAEAAKLVQQLRTEYNTLKSEAASLKSEADSAKVTLAQSESSWEERRQQLEQEMTELKTRREDVNSQNKILHQQLEALTTQVAALQQKRSGGEEEDERMSPVPLGDASDGLRELNGYLRREKEILEVQYDLKAQEAKRLQQQLEYTQSQLDEARLKLDQERTQAAQSGRTSMTHQDLMEKLNELNIYRESSMTLRNENQQLKDQIGEKNKKIEEMEARIQPLEAEIDTLKTQKSFLEDEIKQIQEDRDRWQKRTEGILTKYGRVDPAEMEQLKDKITELETERDALKQGEEPLKAKITELETTMESERNNWSTTRAKIVEQAKERSRKLTGEKNEAIQRANQLQESLDKAKNELEGTKKEAEESRNQKSELEQQIRNFQKEVEQLRQQAQTANSTPTPAQPAQPAEASVSSDVVAQLEQQLADARKELEAINGQKQSAEQQLESLRNELQTAISERDEATKKLQEATVNASAQTTDQTPAEPVAADSTEQPASSISDEEKKALEERVAAAEAKAAEFEQKANEVETRIQTTIKERSDRMRDTLNAKLRESRSKMEEEYKKKDEDLKLKFEQEKQIWLAENPTARNADVTKTEPADQPPATPAKAEAPAVPATPSSVGQTDLSQLDDTGIRQFLATNPTVKNIVAANIKKKLEIESSKLKAELESTIKTEYEPKIAAARDQAQLMESKKSTLRINMAENKLRAANAKISVVEKAVSETPQKPVVEVWEVAKVAVAPPATPVVAKPTPARQGSVAGVPPSPSPATPAAGAKAAQGTPAATPAGQQQAGSDTKPAQAAGPTPATSGIPGPKTNNPFAVPANATTAAAPNPFATNNENGVAPAAKPGQQQTQAPQQAPQQQGQQQGQQQGQQQGQQPVRSGIPMPRGGGRGRGGAYVPPGQRAASGPQEGGHGNAGRGGRGGRGGGRGGMNPSANDFQPGNKRPRGDSEVGGGAKRARGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUM1</accession>
    <name>S0DUM1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable TVP15 Tlg2-Vesicle Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_05039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427148.1">
        <property type="nucleotide sequence ID" value="XM_023571603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUM1"/>
    <dbReference type="GeneID" id="35398520"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05039"/>
    <dbReference type="HOGENOM" id="CLU_120579_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="131" mass="14071" checksum="A1109C9399C1F9BA" modified="2013-09-18" version="1">MELSDIFRIVNLAVGVITVLGGIASIFHLGLQPIVVGAYMIVFGLVIALLEFQIPPQVSRHASFMFSFIGRGVFYVFIGCLLLGNFILSKIAGSIIGIVGLGYIALEFIPSIEPPSNMREAEDAGWGAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUV3</accession>
    <name>S0DUV3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427243.1">
        <property type="nucleotide sequence ID" value="XM_023573011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DUV3"/>
    <dbReference type="GeneID" id="35397260"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03779"/>
    <dbReference type="HOGENOM" id="CLU_003905_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1294"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1315" mass="147011" checksum="60C052461055D5AC" modified="2013-09-18" version="1">MASSNPSGSSIPGPQPSQVSVPENETEPEGHKTLKSHLMSAIQTDNVEEVERLLDQNSFLTNAAICYEVEYNQGSIECQVLPVTIAAKFGRVAILDILLSNFTANIDAPIYSTRTSSLHLAANMAGWSLSGFSYLTERRSIGQTNGHTDIVSFLLENGASSQLRTDRKHTAFSLACYHGSLELQKLLWNQGPETQISLRDQRGNQPLHHAVFNNNHRVIPWLLKKQADIEAYGEGGLTPLCAAAEALLSQGAYIHARSNIGKAIPILYASTRLDSRLSVLLQEYCASLLDTDKRGYNCFHRMLENEGGSWRDFLDVTIQFVAGGANINHLSDGDPSPLASACLEGKLGEARILIDFGADVNQCGSSTGVTPLTMACKRPKNNKVIAMLLDRGADATKTHRHGGTALSIACLAGDSENVETLIARGIDVAHFDRHCHTPLFNAAMKGHFDIMLQVLRTATYFPSNPTNKRAFTDPRQSREVIGKAVLKALEHLPDLPQEDLHTIMYWAVANDYPSLVKKCIEIDNSIVQKTREKANWLHTAAQHSSSQVIRFVSEAGVSEKATNGNTAMHYAAFSGSLETAEELFKLVVTGCPVNTAHAKVRLVMQRNVWDYTPISMAVSGRHKAVMDLFWEEIRCLGTVDKDYLRTHEEQAVEILELVARLEEPGHEETLRHLLEQWCMREPDPQMTTLELAVRCSQATAVWWLLSNGAYSWMDMSALGGIFKPEPGTFHKNINDLLRDNPPNLRSVANPNDDRPPKLPQCREKGTIHFSGFMILRNHSQKKEEKLHEKKLPLSDSSHAALNLLFRWIHLPVAEMRLMRDLANRLSHDSGVSEMDHELMMQHFNSSWTELSAGGGGSYMKPRVATVDHIINSTQLEYTNKPLNNSAAGQRPKQNIPYMDLYTDSSWAKMPYLGFGTYEGSRSSHKDSFDMQRKGIDESIQSRRLRRANHRHMTLDQYYYSVLTDTDTRDRDQVLSKFIDAGNKQTLGTNNSSHDSTPGKKERQILMVYPVRILFLATKLSLETLITATTEKEPDNFLVETIRKNLTGGETRSRFAQPQSIHMFIEQILGITTGFFEWPIVGLKTPLDVFRESIRKVIYQANDEAELFKVFHEALEAERGQQHESTPSWTCSQADAKHDLTGLITEAETAHGSVGSVQSEISHRINLLLDLRQKQASIKEAEFGRIQANDSARQSNSILIFTIVTIIFRAQLPLSFLSSLFALDVSSFPHESGDLKYQGWWLFPILFGVTAIVSVPTIILAWKINKVSDWWNKLEPGVQNGQRFEREADDIGSHSSRRRRFGGAVRKRNTGGDGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV47</accession>
    <name>S0DV47_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_03468</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428520.1">
        <property type="nucleotide sequence ID" value="XM_023575319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV47"/>
    <dbReference type="STRING" id="1279085.S0DV47"/>
    <dbReference type="GeneID" id="35396950"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03468"/>
    <dbReference type="HOGENOM" id="CLU_012510_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="441"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT66439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="718" mass="79605" checksum="B09E32D994D8DC55" modified="2013-09-18" version="1">MGSTSTSSTSGQTAPIQMTGKSNAATPKLNNEVEMGSLPGDTQAQEEDIMQIARIGDVPAMEKLFESGEYDATYHDDEGITPLHWAAINNQYAMCKFLIEHGAEINRKGGESVATALQWAAQRCHYYTVNLLLQHGADPLITDAQGYNTLHISTFNGNVLLIVLLLHQGIPVDVIDTFGHTALMWAAYKGFPQCVDLFLRWGASVHATDEQGFTALHWALVKGSPGCILKLIEYGADRFAKTQTGKTPAVTANELNTEGAWHRALRECGFNEDGHPAVPPWPGASYFLKDKRAFVTRFLFIWPFVLVWGMLMAVSSAPIYIGVPLGFAVVYGVQWVAQQVLEYAPPDMRHFHKTPWLTGIFAATLFLTAVNWLTTVLFATTLGASEGHGHTFLNLFFGIFLGLTAYFYVASMRYDPGFVPKMNGIAEQKAVIDGLLSQWKYDETNFCVTCMIQTPLRSKHCRRCQRCVAKHDHHCPWVYNCVGINNHRHFFFYLISLTFGIISYDFLLYYYFETISSNASDSCNVLSPNLCKFINADSYTSILAVWITLQLLWVTMLLFTQFIQVARAMTTYENMFGVRDGTAITALTSTGAPLDPNHPSLSATATPGGHHHKHKGGMLKSLSRTLGVDPFIETITGRGAVSTKNKRKKKNPYSRGCIANCKDFWCDPAPIFGQRENGAAVLGGERVDYTAMYESPGLMQLTGRRERGGYEAVGTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVM5</accession>
    <name>S0DVM5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Attractin/MKLN-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_03651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428690.1">
        <property type="nucleotide sequence ID" value="XM_023575521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVM5"/>
    <dbReference type="STRING" id="1279085.S0DVM5"/>
    <dbReference type="GeneID" id="35397132"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03651"/>
    <dbReference type="HOGENOM" id="CLU_012508_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21699">
        <property type="entry name" value="JMTM_APP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495238" description="Attractin/MKLN-like beta-propeller domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Attractin/MKLN-like beta-propeller" evidence="7">
        <location>
            <begin position="27"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT66609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="589" mass="65588" checksum="9A98655EDD14D7B8" modified="2013-09-18" version="1">MAPKFRLLSIAVLVTTLHLSIQHDPVKDFCRRFGHQTAVVDRKLYIDGGLINWKPLETDPKNYTNTWLMWHDLDHNSKDNMPQIHANLSKNVSVPSVHGGALWADDVNYRLFLFGGEFFSGSPTTSNFMSYDIWYDQWDDFGPPSDDIKRVSYGASTTVKERGEGYYYGGYLSRASVPDWSGERHATSDLIRYQMDTNTWAKLSGPDDTKRAEGVMTFIPASDRGMLVYFGGLQDPGDNGTMVSQPLDEIFLYDMISNKWHVQRANGTIPESRARFCAGAVWAEDRSSYNIYINGGHGLEGPGFDDVYILSLPSFTWIKSYPLDQNGTGYYPSHSLSCDVVNQGSQMLTIGGAFPKDETCDVEEVWGVHNIDLGNQIKSNFKKVWAGYEPSLFGYKVPSFVTSVIGGTEDGGATKLKPDYGFVNHDLGTLLSMKATFTSRTRLDDGRTDPRASESEGGSSSKAGLSKGAIIGIAVGAGVVALAVLIGLWLLRRKRKIQRDIQSAPTTESFYSVPYMPQTSSPLNFPQSPEGWRRGSPGVREYEGEDPGQVHYWRPFQVNVEPCEMDGQGTRLPETHAEIEFIRSRGFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVP2</accession>
    <name>S0DVP2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428637.1">
        <property type="nucleotide sequence ID" value="XM_023575458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVP2"/>
    <dbReference type="GeneID" id="35397075"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03593"/>
    <dbReference type="HOGENOM" id="CLU_2574065_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="87" mass="9902" checksum="EE082026268A2460" modified="2013-09-18" version="1">MSQNTEATKRAQRALEEHGPLEEVEPNIVGIDGHRFRINYGVPQEVTNRLNALCDQDEVKYEDIPDDLKAYEVKEESKDGNEENSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0DW33</accession>
    <name>S0DW33_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MADS-box MEF2 type transcription factor MIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04051</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription factor acting downstream of the MPS1 MAP kinase (MAPK) cascade during conidiation and plant infection. Required for overcoming plant defense responses and the differentiation of secondary infectious hyphae in live plant cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with MAPK MPS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426784.1">
        <property type="nucleotide sequence ID" value="XM_023572709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DW33"/>
    <dbReference type="STRING" id="1279085.S0DW33"/>
    <dbReference type="GeneID" id="35397532"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04051"/>
    <dbReference type="HOGENOM" id="CLU_024080_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000013">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="373"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="583"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT64703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="654" mass="70198" checksum="9385419262C8AC63" modified="2013-09-18" version="1">MGRRKIEIKAIKDDRNRSVTFLKRKGGLFKKAHELSVLCSVDVAVFIFGNNKKLYEYSSTDMRELIHRYQYHGGPSEHKGPSDFNGGNDDDEDEENDGTPPHGPEVVENQMMPPHAYGQHQPPFPQIRHHTPSASPPIGNGGPFQAHPGHPIQRQHTPQPSIGSRPASRTDMRRMGPGMVQPPPPPGPPHPGMNYMPNPPIYNSPHPPGLIPQHGPGPHPQYAYHQQPSHMQQPGPYMDDRRSPMPSPMPPAYTSQPPSQPIQAPVRPTPSPQPPQQQLPPNMSQMSPPPPQPERRLHDPPPPPPVEPKTEPQERPQPPLLNTDSAIKKLPQRKSHSIFTPIEENRSILSQHLASFTSESNKSESAAAAAAANAANAANRSQSVDVAALNRATDGPKSSPHLPQRASTQTDEKSRTVSLSSIPETTLTPPSRSNSAKAGGPGGARPRGPRLTVQIPDGGSEGSGSARTAESNSPRVATETTTQAPQRHNSQSSLVLPPPSPSASAIMSAGATGPPNPFARPPPQQNVNGDTPVSALPSRFLTNELLPSPSSFYPDWNFRGGDSNTLPSPLNFATPVVGSGPSFLRDDLNTTPNANSNVSKDRDPLTGANGSLGQNLSVAPNNSTATKRKTPEPGATTQSDTADESEPKRLKVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX28</accession>
    <name>S0DX28_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_13305</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429200.1">
        <property type="nucleotide sequence ID" value="XM_023575976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX28"/>
    <dbReference type="STRING" id="1279085.S0DX28"/>
    <dbReference type="GeneID" id="35406759"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13305"/>
    <dbReference type="HOGENOM" id="CLU_031730_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495283" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT67119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="270" mass="29528" checksum="A960C8063C59FB7D" modified="2013-09-18" version="1">MTRFKAACWLALLLPAIIVSAHGHVDEIIINGVSYQGYGSTDFPYMENPPVVAGWTISQRDNGFVSPEAYGDPDIICHRDATPAEGHIEVTAGDVITLRWSGWPENHIGPVLNYLANCKGPCERVDKNELEFFKIDGLGQLEQGTPGRYADSVLQENGDKWNVRIPENIAPGNYVLRHEIIALHNALERGGAQNYPQCFNLRITGDGSDSPSGYLGTELYDIEDPGILVNVYSRSVDYEVPGPTIVEGGTSSVEQSPSRATTTAKCTSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXN7</accession>
    <name>S0DXN7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427319.1">
        <property type="nucleotide sequence ID" value="XM_023573866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXN7"/>
    <dbReference type="STRING" id="1279085.S0DXN7"/>
    <dbReference type="GeneID" id="35395649"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02167"/>
    <dbReference type="HOGENOM" id="CLU_012494_13_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="94"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="327" mass="35664" checksum="4FDC88BD0553303E" modified="2013-09-18" version="1">MSVNVRPVQVSSSSQQGRLELADRLEKLLANDKPWHEFPTPQDYRDARRDGTNGFKKPVCNDKARLIDFTGREGNSIELRVIEPTTGPSKGVWLHFHAGGFVIGSNASYDPYLTRLSNELGLTMASVEYRLAPENPYPAGYNDAVDAALFALSEDGANKLGAQLRVLGGESAGAWYAVSVALALRDKHGVDVQSQLSAICAGYGIFDLTYTPSCLNHKRNIVLSSDGMQRFGEAAFAHVPLRDRKTRYISPLYADLGNLPPAQFLVGTIEPLLDDSIFMAAKWANSGNEVDLHIVDGGCHAFTLIPMGDATEEGLQSVISFVKKHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXT7</accession>
    <name>S0DXT7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_13586</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429460.1">
        <property type="nucleotide sequence ID" value="XM_023576288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXT7"/>
    <dbReference type="STRING" id="1279085.S0DXT7"/>
    <dbReference type="GeneID" id="35407040"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13586"/>
    <dbReference type="HOGENOM" id="CLU_006301_8_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="482"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="318"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="756"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT67379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110385" checksum="5FF1140A94C7A736" modified="2013-09-18" version="1">MLRVRTLQERSNSYVCALCRHKLSPSDSQSRDRHVSSVGATITSVRATRPSSCHYLRLSGVRALSTSSILHGPNDNGKPGGFPGRGFPGGFGAGLGSFGAFASKPSPDTSKQSVDLLPHEQEARKKMGLPLKKPLKVEAAPTPPPAQNNVKKRSDTQNANQNQSQRKNTSPARDNQQPNRSNDGNKYARQQRHQQQQQQRDAKPTTPPSNLLPAAPAWGAFSARKVDTQIPLISRKAEAKPAESQNKNKSKNVAPATGQEEGESVWGQLKRSRKLEEKPSRGEDGFWDALESRVTNIRSRPGPGGQYLEALQGADGMLRGGQQSQEDQIRRKSRFEMEESDVSDKRRDKKDKRPKNVHRNEAEDDDFDEDSIRRWEARQRKKAEKEARKRLEEATEAAPVPIFLPEYISISNLAGALQIRIADFLHDLESMGFEDLTEETIMTGDTAALVAQEYGYDPTVDTGSQRDLQPRPAPEDPSLLPSRPPVVTIMGHVDHGKTTLLDWLRKSSIAAQEHGGITQHIGAFVVQMSSGKQITFLDTPGHAAFLSMRQRGANVTDIVVLVVAADDSVMPQTLEALKHATAAKVPIIVAINKIDKEDARVDQVKADLARHGVEIEDYGGDVQVVPVSGKTGKGMQDLEENIVTLSEILDVRAEADGMAEGWVLESSIKQTGKTATVLVKRGTLRLGDIIVAGKSWAKIRGLRNEAGVEIPEAPPGTPVQILGWRELPDAGEQVLQAPDEGKARTAIEYREEMAERLESSKQLAEQEQRQREKEAAEEAAAAAEAEGTEAEPAKTEPGIIYQNFIVKADVAGSVEAVCGTVQELGNNEVQSKLLRSGVGAISEYDVDHAAASKSIIVNFNMPILPHIRQRAEEAGVRIIDHSVIYHVVDDVKSALSDLLPHTITNKVLGEADVLQVFGINVRKRVQKNIAGCKIRNGTIKRTSMVRVIRGGEVVYDGKIDTLKHVKKDVMEMGKGTECGIGLEDFQELQIDDQIQTYEVIKERRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYS4</accession>
    <name>S0DYS4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429792.1">
        <property type="nucleotide sequence ID" value="XM_023576669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYS4"/>
    <dbReference type="GeneID" id="35408086"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14706"/>
    <dbReference type="HOGENOM" id="CLU_052452_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="430" mass="48597" checksum="6ADFA9114CC89360" modified="2013-09-18" version="1">MNSLPDEIVSIIITKVTAHELAQLSRACKRLNRLAEPLLWTNIEFHHHTFHQASDLKKPSPIASASHRFYHWDTEYPGQCKAEKFFEMLQDLLLEDIGRLKKLCSRVESICTVVRSKTDFWRILPYFTNVKALELYGDSSYFDQDAHRSFCQSATVLTKLRHVKLDGSIPLAVAKWILKSCSTVERLELGLLDKPIESRATMEDDFQCLPEDIYSPPEGPTYGRLRGWAVIPRPLSGFLPFHKDATSLRLPRLRHVHLCQSSQSNLSARMVSYFWSTSAEVSAHKDWDSILQASCETLETLSVEQQIGIEHGDGAVDDAEGFFRSDQDGLGSERLMLMLERALTTRKFPALKRVYLKGIVVGSKERGEPIGDVPGGRFMRFLLTKGIACEARLGEGYWFDGDDGTGPPAEWDACDDDWEEELLASVGSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ46</accession>
    <name>S0DZ46_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_03700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428738.1">
        <property type="nucleotide sequence ID" value="XM_023575578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ46"/>
    <dbReference type="STRING" id="1279085.S0DZ46"/>
    <dbReference type="GeneID" id="35397181"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03700"/>
    <dbReference type="HOGENOM" id="CLU_030571_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT66657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38419" checksum="6A24F520F8F8F593" modified="2013-09-18" version="1">MASQNKSPPVYVTVSALDAGHLTLPENLFVTEAHCNKRATVPSLAFFVKHPAYGGGRDVNLVFDLGLKRNLTGYPSKQQEHIANRHPIISRPDCVDSLQYGVDWEPGSNGETLLDPATDVVMVILSHVHWDHVGTPSDFTNACFVVGSGTLDLLKHGAGPLYPTEIFNDDELPASRTVELPAVPYATKEEGYDAAPHAPKHTHSLPETVATLPSCVPVDLWSWEPLANLPHVLDLFGDGSVFVIDSPGHLYGHINLLLRVAERRFIYLGGDCCHDPRILSGQKGIALYDDGKGGMRSVHTHTGVAQKTLGQIDKFANEMSVNEGIEVEVIVAHDKTWREKNRHRFWPGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZE4</accession>
    <name>S0DZE4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429856.1">
        <property type="nucleotide sequence ID" value="XM_023576778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZE4"/>
    <dbReference type="STRING" id="1279085.S0DZE4"/>
    <dbReference type="GeneID" id="35408173"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14794"/>
    <dbReference type="HOGENOM" id="CLU_055465_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21091" checksum="07864F019227C46C" modified="2013-09-18" version="1">MASRRPDLSQYPTGFTVLRIFQAVLNIITIVVTSFTINAVVIPGNCLFIATSSASLLVSTWMAFAHMFSNRLFSYLVAAILDIILTLFWLVSFAVLAAQTAVLWAHGTDYCENNKCPDSLKNVTSFYGYVFATCVGLGGLAFLFSCICLIFHGIVSCRQHRYNQIGTNNVSEPIFVGDRHPQGTTEYRPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZT9</accession>
    <name>S0DZT9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UvrD-like helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_02986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428074.1">
        <property type="nucleotide sequence ID" value="XM_023574780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZT9"/>
    <dbReference type="STRING" id="1279085.S0DZT9"/>
    <dbReference type="GeneID" id="35396468"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02986"/>
    <dbReference type="HOGENOM" id="CLU_010692_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF66">
        <property type="entry name" value="UVRD-LIKE HELICASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="5">
        <location>
            <begin position="133"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="721" mass="81001" checksum="5858D792D68FD2B6" modified="2013-09-18" version="1">MHLLLSAWSRQRMSCYSRHIGSSRLFTRNHSRLQCVGTKPAFEPSSQQLRVVKLCADQNVVVSARPGSGKTATIEAIAAAHPDKRIGSILFSKRLQSETSHRLKKYHNSDVYTFHGMAGVLLRQVVPSDEALIKLLENINKCGKLPRCASKPFDIIVLDEFQDCNPETFWLVECFVRANNLRKGGQPARIVVLGDERQSIYRFRGADPRYLTLAPEVLGPTSPYPFAEVQLGNSFRLSSSAVQFINRVFLGGEQYISSSRRGPKPIVLRCNIWDNLAVAGAISPLIRRYKPENCVIIAPSIRTKGPLQDLTNALAQVYGLPINVPTDEETPLDDIVINGKLCISTIHQFKGRERKLVILLGIDASYFQFFGRDLPDDGCPNEVFVALTRSLQQLILVHNDERKMMPCVSLDSLYDTAKIVTLTKKRTKISHPDLPGRPLGLGLMLPKSCGACEITRYVQGDALDKLIEGHLRVDRLAPPLPRHEHINIRNVVLSDPKKGLYESVSDINGLVVVGALELETAGTLRSLGRPSEEEKLVAWLCRKACEYEASLSGYLPRVIQMKDHKYDWIKPEDLILARRQLDSELVDSAQRLNFEVEMQQQFHIDGQETQLCGRADIVKNSTTESNGNMDNRTVWEIKFVSSLSNEHVIQTCVYAYLLGSESGKLPRIILYNVRDGDKREIIPRHGIEGLRQLISSVLRLRYTSKGDMTYEEFIKGCSNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E066</accession>
    <name>S0E066_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430334.1">
        <property type="nucleotide sequence ID" value="XM_023577232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E066"/>
    <dbReference type="STRING" id="1279085.S0E066"/>
    <dbReference type="GeneID" id="35400502"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07025"/>
    <dbReference type="HOGENOM" id="CLU_045417_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="381" mass="42895" checksum="2E850F88FBD0A041" modified="2013-09-18" version="1">MATPSCIDIEQTPAVVEWEWEGATRSLATPDPDNVPIRFTIHTDSTHDKHRAHFEIVVPVKFKDKPSSAAVFLRISPLFITCFRFSTNIDTLDSIKNQRFDSATCLEFELSNSIAVLVPSYVKEPVSASRPRSGKVLDSLYELSHVIALRIYIQDSLLSLDQLNSISDTVTKGHLEPFSGPEYDISRMFSGSGAKATNLAAPKPPSYEKATSSHSQPPSAPSYQRKRPRQDSPQGPDSISQVWDKLQKLESLFHNKVGELTAENAKLRDQKPKPDESQAETTQSTDQSQVVIELRAENAQLREEVERLKKRQEDLEAEVASLQTAQRSEKDTEEVAIIEIRDDIESLERRLSWVENGKDEYFVKQIKQEIFDELATRVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1I3</accession>
    <name>S0E1I3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable transcription activator protein acu-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_07541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430809.1">
        <property type="nucleotide sequence ID" value="XM_023577805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1I3"/>
    <dbReference type="STRING" id="1279085.S0E1I3"/>
    <dbReference type="GeneID" id="35401018"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07541"/>
    <dbReference type="HOGENOM" id="CLU_007124_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15485">
        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000007">
        <property type="entry name" value="C6 transcription factor FacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="604"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="723"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="829"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="835"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT68729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="890" mass="98928" checksum="4BCBF807748B4687" modified="2013-09-18" version="1">MPGILPMKVIKVGTSSQSRIAQACDRCRSKKIRCDGIRPTCSQCANVGFECRTSDKLSRRAFPRGYTESLEERVRQLESEVRELKDLLDEKDEKIDVLSKIHGNRSSSTMPASSPAVPESRNEALAAKEDTFRVQAAPLLLGVENSDSYFMGASSGRTFIESFKRKIQETGKPSTDFNTEAFLHIQGCKPLGPKSPEQSFRLPPRLFSDRCVNVYFQEWAPLFPILHKPTFLHVYEEFVADPEKIKGNHKLAQLYLVFSIAGLSSENPDLPQLAACEHQWQTSLDAVLMEDTMNTLQCLSLALLYCTMRADYKRLQHYKGIAVGLSHRLGLHQSQKRFSFGALTIETRKKVFWTIYTLDCFSAATLGLPKLFKEEDIQTEYPCDTDDEYVTEKGFQPTLPGEYTRLSNALALFRATRILAKVLEKNYPASSSYEISLQQMAALESELDAWYDQLPTHLRLNFVQDKPSTDVTGSRSPLLALAYYYIRTLIYRPAVGSSLGSKAASALMSIGASSKHIVQIVQLLEERGMTFSFCLNKTDLLVVCGMALLYHSIDLKQDSKLMRDDERLVNAVIHILDKSEGSGSLDFKRVASVLVKVDESAVSPMHTSREVSMPPAPVSNRGSPPRGMVTKPKKKGRAACPLGQLPAAAASESNLIDHQERLRRMTMPCVADQRPEFYRARGRQSFDNLQAEVPMLQRGHRMSMSPNPDRKASSLSRNLDFMPFAHSSQSPQPTSPQQTRAHSHSGPTNQAHHMMESSSVAAAKVNGVSTTEWETLLGSLDGGMNNVYDAIYGGQGLVNESAIAVSNCGDWPPDNWDLGGFSIAEFGNNPQPPQSVLSMSDESLSSGEEVGPSELGLSVENVDYRNHMVTQQHGHEGYMMPDHMETFPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1W6</accession>
    <name>S0E1W6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429738.1">
        <property type="nucleotide sequence ID" value="XM_023576583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1W6"/>
    <dbReference type="STRING" id="1279085.S0E1W6"/>
    <dbReference type="GeneID" id="35408009"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14628"/>
    <dbReference type="HOGENOM" id="CLU_120161_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="129" mass="14454" checksum="4645384D9FC0C670" modified="2013-09-18" version="1">MPILNDVQLSSPKDLVSLARGDEPIYVILTSSNDEETGAPWCSDVRAALPFLEETFGKPDGPKAVYESVGPRPGWKKSDNPHKLTWNISAIPTVIRFELRDGRIEETDRLVEAEVYEEGRLQNFVLKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E270</accession>
    <name>S0E270_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cellulose-binding GDSL lipase/acylhydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429833.1">
        <property type="nucleotide sequence ID" value="XM_023576735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E270"/>
    <dbReference type="GeneID" id="35408145"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14765"/>
    <dbReference type="HOGENOM" id="CLU_015101_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495474" description="Cellulose-binding GDSL lipase/acylhydrolase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31261" checksum="2FA5D6F7D673F228" modified="2013-09-18" version="1">MRSFLQLLSLAAGLSQATATPVLSRAAGAAKNLVVFGDSYSTVGFWPGGDLPSPGSPLGNPALPGQTTANGLNWVGQLASVLNTSSVLTYDFAVTGATVDKEIVSTYAQYCVDDQVAQYREYVANKISSAETLVAVWIGINDLGEPFWKKSAAPIEKTMDRYFELLKMLSEAGLKKFALLTVPPFADQIPAMIGQSESDLKTLRADIIAYNKALTERAATFSKSGSGIEVTVFDTKPTFDTAVKNFKEYGAKDATCYGANECLWTDTYHAGVAIHKALATNFAEGVSKVFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2A6</accession>
    <name>S0E2A6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_07660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430920.1">
        <property type="nucleotide sequence ID" value="XM_023577937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2A6"/>
    <dbReference type="STRING" id="1279085.S0E2A6"/>
    <dbReference type="GeneID" id="35401137"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07660"/>
    <dbReference type="HOGENOM" id="CLU_125186_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT68840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="96" mass="10959" checksum="1BE6E5DBDF56B87A" modified="2013-09-18" version="1">MTGRGGGGGRRLMLPPIKYIFELLREHATVSIWLYEQLSIRIEGKIRGFDEFMNLVIDEAVEVKQVTKTNEKETRRPLGQIMLKGDNVSLIQNVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3V6</accession>
    <name>S0E3V6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to Orc3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429484.1">
        <property type="nucleotide sequence ID" value="XM_023576316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3V6"/>
    <dbReference type="STRING" id="1279085.S0E3V6"/>
    <dbReference type="GeneID" id="35407066"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13612"/>
    <dbReference type="HOGENOM" id="CLU_017272_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="188"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="499" mass="56858" checksum="064971EACACF1DFF" modified="2013-09-18" version="1">MADFDEAPYTHEEDEEQLWGELDKCVSSKCDSHETIDDALRTWIDLTTRLRDHLYDSQEEVVTCTRMLLASDLFQANKDYVRTQIIYSLLQEDEAGPLHAIVSLLLLDGCQDETMFPRMVNEACFPRLLELINGRRDQDPGLHRLLLQLMYEMSRMERLRVDDLTMVEDEFVHYLFALIEELSDDAHDPYHYPTIRVLLVLNEQYMLASTEVDDSASPNSPLTNRIVKCLSLHGASFRTFGENIILLLNRETETSLQLLILKLLYLLFTNKATYEYFYTNDLRVLLDVIIRNLMDLPDEKMSLRHTYLRVLYPLLAHTQLSQPPHYKQDEILRVLSILRGSHNVHFAPADDTTLRLVDRVSKVKWIEEAQSPTVGSGEAEVARRFIGISLSRSQTASSISVSDVAAVKEKPGVQTPSRSGDGGDVATDDDNVPMATRPKKPLPEVPKHRHGVPFAQKFANGGPKKTPPKAPPPRRWGRMKTVEKPPTDPVQETVPEQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E531</accession>
    <name>S0E531_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to ankyrin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430892.1">
        <property type="nucleotide sequence ID" value="XM_023577903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E531"/>
    <dbReference type="STRING" id="1279085.S0E531"/>
    <dbReference type="GeneID" id="35401106"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07629"/>
    <dbReference type="HOGENOM" id="CLU_020808_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="467"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="646"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="710"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="783" mass="84755" checksum="A0B52E374C25DD52" modified="2013-09-18" version="1">MDQLQSRVEKADLQDLIDICEQLSEECRGISNCLNTSPVTLASLAKECRAITNALDRLHELSRSIEGGTESVRASNNEFVYSVSKDVHELRAALKRIKGPDRDSGIHLSEPQLIIVWNEAALKEYLARLRTHQASLHTLLNAATRQVTFFSRCTGSRLTLSSAGYNFGENDNRRRVIEPDIGVDEALRSLARKFTAPNQQSVVLPRVSDSAEIQVLLDTLVPPPGVNYVRTKDAANELHNAIERSDETAVFHILLERADPNIMLAGSMLSPLHRAFDKGHMLIAAFLIVAGADVDEPTTDGHTALMRGIRCGFSEQFATLVIHMKARVNAIDNDGCSALHLSAASDVVDDETLPVLIDAGAEVNLVDYDGQTPLLVAIQHSRWSAATKLVQAGADLEVRLPDGKTALHMAIAMRNQEFSQVLISRGANVDRVLREHTPLTMAINSRCTAITAVLLDSGADPNLPSRNGNTPLLAAASTGHDETVRYLIAHGADPAATQGHSGYSAMHMAAHKDKPHILQLLFDAGAPVDILDKTGETPLLVAAKLGNAQSIFRLIRLGADVERVGPDGMSILSHAVKMGDVDLVTALLELGAGMQVSSMFPSKGSKEYLVPEPQTTPIHVAAQHARDEIILRLVSYGASLESTIFPGRTPLSVAASHGHILTVRLLLRLGANTHALTTHGDTILFQASANQATLKLLLQQGIDVNHQNDRGATALHYAALRGHIGGVRMLLEKGARQYHANAVWDAWEDRDGTGGYRQGTPAGMAMQRGLDKVAELIEGWKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E547</accession>
    <name>S0E547_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to alpha-1,3-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431895.1">
        <property type="nucleotide sequence ID" value="XM_023578976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E547"/>
    <dbReference type="GeneID" id="35399210"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05731"/>
    <dbReference type="HOGENOM" id="CLU_036740_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="452" mass="50883" checksum="D0D55020E6C0C1BC" modified="2013-09-18" version="1">MYRRFIAPLLAVFCFLLVVTSLYLGRDHLTWRSVSYTPVQKGEVEDSSSLKSTTSVTTTRAKIEESPSHTPTPTATSAPTPIISNGNMLSAERISPYIAAILNPLSTVLPRLGCPALNENRYKILQESRHGDEVGDSQIDYFFAFNLRSCTNILPRLIGSIVEAVRFLGPHRCVLSIVEGNSLDGTSDILSALRPFLEDLGLVYFYNSSNINPAQGNGRVHKLAQLRNLALTPLYKEQVKVTDETTVLFINDVSACTEDLLELALQRRSLNADMTCAMDWTYVGPDPTFYDIWIARTIAGDSFFEVGSDGNWNSAWNLFWNTPGTRSRYHAQQPFQVFACWNGATAFTAAPLLHGLRFRDTRKGECFQGEPQLFCKDMWSRGFRKIAVVPSVNLEYSDEKAADIKKLKGYVSDLVERQEEDGAIDWAYDPPEQVRCMPTWDKQSWRAWNETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E558</accession>
    <name>S0E558_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429834.1">
        <property type="nucleotide sequence ID" value="XM_023576736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E558"/>
    <dbReference type="STRING" id="1279085.S0E558"/>
    <dbReference type="GeneID" id="35408146"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14766"/>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="335" mass="37925" checksum="94D01E1A79AF7CE8" modified="2013-09-18" version="1">MADPISTADPVALEVDEADTNTASDTDSLGSIEGSSTSSITSSILKYRQENGRTYHAYKDGQYVIPNDEQEQDRLDLQHHLFLLTFDHKLYLSPAGREGRQLHNVLDVGTGTGLWAMDFADEHPSASVIGIDLSPIQSPFVPPNLSFQVDDIEEPWTFHVKFDFIYSRMMTASIADWPGFFAKAYDNLNPGGWIELADIYPITSDDGTLAKDSATHEWVTRLLDGTKMIGRPFDGANKYKEQLEAQGFQNVQQVVFKWPQNTWPRYKKHKELGAWNLENISSGLEGLSSAVYTRVLGWTKEELDVLLAKVRREMKDRTIHSYWPIYVVYGQKPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5Y5</accession>
    <name>S0E5Y5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to SEN1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_06162</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432290.1">
        <property type="nucleotide sequence ID" value="XM_023579456.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E5Y5"/>
    <dbReference type="GeneID" id="35399639"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06162"/>
    <dbReference type="HOGENOM" id="CLU_000459_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase Sen1 N-terminal" evidence="9">
        <location>
            <begin position="87"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase SEN1 beta-barrel" evidence="12">
        <location>
            <begin position="1188"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="10">
        <location>
            <begin position="1337"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="11">
        <location>
            <begin position="1640"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="913"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1097"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1874"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="929"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1897"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1956"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2043"/>
            <end position="2056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="2058"/>
            <end position="2079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT70211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2079" mass="232867" checksum="3EC58ADAFF562595" modified="2013-09-18" version="1">MDLHEQLSQWYEKIQRFDEECHLLCPRINDEDNENYKLVDDPDSSITQEEKNSRVKAGKERLEVTYWNCLIFGFDKSSQGKWGEQLSERLNGCLKHCADCVYNWHMQRRELLQQFQERWNEEVVVDIRSMLEQRDVERIDLSLRWAKGFIEKIISEGSTFKKSQLGEHLPEVHISIYEALCCMPYMEHADRRMTFQYVFQRLQGKSGLKLGTKEPLPGMTYFIFDLKNQDRRKWATDNYRNLDSNSMTLEQFDWAVSSGLTRAIEDISKREASAVDSWPEMAQFWEGFNEILRTLTADVIMQRLRNLELSGTISHIYDLLFRHIQYCPAESVLVMTITILTNFLKKAPRAFWDVIGDARPNVIADLIFASPGYKNLLRQSLEDCWTGYDGSISRGPFPTSWIDPWLQSVGRDRRYNACEILMHTLFESLAKDEAIGEPGRAACIRAGFDALQLTISTFVDPETKIGAGTTHLYACCAFNLVMKYKGIILRNLRAPGDEREGWVTFQVAHAAKKAMQAAMKLDMKVFAEEYIACLEGSQLQSAVTRDSKAFWQGIIEMFDLSTEQVDLARDIVLSLEPLIGVEQIRALKSDDKLSDSSKNFNKSLAATVDILGNLLGRMSEIDAATDLNTFFDDRLAFQGTITLSTHGEAGLAEAAAELLKSWTGEYSQSGAFEQMSQLHPEQTLSSIVWALERVLKPPYPWGPIRPMLNMSRDILRGLTDPMSGVLRVKTLEPMSAAKVLRWWSEQWRFVSTACRNIEGWSRYIQNAVMTEFCREIMELAEALVAEDGLITSAISKALNKSEKDTMSQILIPAKQHFGGMENMIRLKDKWLVDVTVRVLCKILTRLRENNHEINPASRKLITDACLPTNVPGKFVRSTNMTDQQRAELLQALGQTDDEIQIYQLGIAQTPLAQRPKDGIKKQSKLDAWSKSGTSSSSTTTAASSRSNRDDVLDLSRSIDSPILRQLEAKKVKDQAKAKTKAQAMIKPRTQIVPDRKDIAALKEARQKAKLEKEKRDAAVIANAKALRGETVPGEGSGLLSLGLIGKDHGRSEIMVNSSEEESDEEEDVSDADNELAALSTGGQTALEEANKRRMAKALQDKMRRPVKKVRQQRSVKDRRARVIPPMDRLHNTVLAWDIFHGGNDPPNGPAASEVATKYSEPRTYQDTFFPLLASEAWRSFVTAKEELTSQPFGMKIASRASVDSYLEATFTMPVVQSRERGVSEGDILLVSESEQPLIDQTARHCLARVHRITYKKELIEITYRVASRNNPMTQVLTPNVSVFGVKITNMTTIEREFAALESLPYYDLMDEILNAEPSPILQYGDEKISNCMNNYALNRGQAMAVLGAHDNDGFTLIQGPPGTGKTKTIVAMVGTLLSEQLSQPGNQGIPMGVPLRPNGAPGAPKQSRSKKLLVCAPSNAAVDELVLRLKAGVKTISGKTKNINVLRLGRSDAINAAVRDVTLDELVKARMEGDQTKDKAKADRDQLHENAGKVKEELGKLRPQLEAAKLMDDRTLYNKLSREFDELKRRQMSYGKQIDADKSSGNSVAREMEMRRRQVQQEILNSAQVLCATLSGSGHEMFRNLEDVEFETVIIDEAAQCVELSALIPLKYGCYKCILVGDPKQLPPTVLSQSAAKFGYDQSLFVRMQQNHPQSVHLLDMQYRMHPEISLFPSREFYEGQLADGQNMHELRQQPWHKSALLGPYRFFDVQGVQERGHKGQSLVNTKELDVAMQMYDRFSNEYRECDLTGKIGIITPYKAQLYELRNRFRSRYGENITSIIEFNTTDAFQGRECEIIIFSCVRASSTGGIGFMTDIRRMNVGLTRAKSSLWILGDSRALVQGEFWRKLIEDAQARDRYTNGDVLSMFRKPLEKAKPGAYLPPPPQARDRDVPMRDASLGTSSLSSSRPNSPKVEGAQRPTAPTTHIPGIAGGESAGVLPRSAGPPVIHTSSSKPPGEPRKRPHDGPDSNQPAPKRTASDNARGGGLMGKFGNKSHRPPKAPTDPSAMSVMGLAPPERPPAAAPTGPSLSSRPQAPTGPRIPTGPSNPGPQYSNNQQRRPPHPPSSRKKGKPSLFVPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6I9</accession>
    <name>S0E6I9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432515.1">
        <property type="nucleotide sequence ID" value="XM_023579732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6I9"/>
    <dbReference type="STRING" id="1279085.S0E6I9"/>
    <dbReference type="GeneID" id="35399887"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06410"/>
    <dbReference type="HOGENOM" id="CLU_057752_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="249" mass="27897" checksum="A20DF485894F5611" modified="2013-09-18" version="1">MAPQGVEGFLASLKEYYNTDYLSDITVTCEGQVFKAHRIILSAHSKCFAKMLNGNWKNVGELEGNVEIKDFNPGVVNAMLRFIYSFEYNNTEGTPQMIFDAHMYQIADKYDIAALKTESKKKFELSIANGWATDDFPVAANLVYVSTPSEDRGLRDLVVEIARKNIDQLVSKDGFCELTRETPDFSADLIPFLCGKGSGPRSVQTYTCQSCYQVVQGEFAAKVQFCPFCSQRLPNLRRQNSLFGSSPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E756</accession>
    <name>S0E756_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430428.1">
        <property type="nucleotide sequence ID" value="XM_023577343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E756"/>
    <dbReference type="GeneID" id="35400602"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07125"/>
    <dbReference type="HOGENOM" id="CLU_127830_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="126" mass="14558" checksum="9A220AFD34144BE2" modified="2013-09-18" version="1">MDEEDPLASFAFADVSSDEADEAKATKSRRTGQSEEAWRVVQKQYKAKVENGDIFQKAKLPLGPDATKMDIQEVIHAVEEHYFFHRYREAEQLAGEALKDGQGLDRDSRQLLEAYRDRCHEKHEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7E4</accession>
    <name>S0E7E4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to capsule-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432865.1">
        <property type="nucleotide sequence ID" value="XM_023579890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7E4"/>
    <dbReference type="GeneID" id="35400030"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06553"/>
    <dbReference type="HOGENOM" id="CLU_005027_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF61">
        <property type="entry name" value="CAPSULE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="48"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="176" mass="20405" checksum="FEC6AE154632AD39" modified="2013-09-18" version="1">MPFGSSVAVQKVKSSFLNGRLFDVTFTRIFQCQRKACGDQDAYFDTKSWVDKDEALKSTLAFDIDGNGISGRYYKLLASMSVPIKQTLFLEWHDDRLIPWLHYVPVSQSMEELPELVFYLTSNPSGKEVASQIARQGRQWHTRAFREVDMGLYVYRLLLEMARLQDPQRKANVPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E849</accession>
    <name>S0E849_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432046.1">
        <property type="nucleotide sequence ID" value="XM_023579160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E849"/>
    <dbReference type="STRING" id="1279085.S0E849"/>
    <dbReference type="GeneID" id="35399375"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05897"/>
    <dbReference type="HOGENOM" id="CLU_003431_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF2">
        <property type="entry name" value="HELICASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1132" mass="125149" checksum="8B9DD02FE5FFF2D9" modified="2013-09-18" version="1">MPLSKPRPSPRSTATSSFSDTTDKSGPKLTDENKNAPSQKRHERQKSRGLLLPQSQSGATSIATTSIIPTKSPIADGDAQNENDENDPIDGSGAIGASASTGGRFTRPDYLLHGLLTRAKNRVKDRTGRDKEKGNGDTTSTVTSPTKAFSSSPHSPPPRAAPPDRGFRRKAPPRASTGRSQGTKTPSSSQSPSHSPPRALTSPRSPPDQNKPLPPPPPLPNSGALSDKENATSPPSNPVLKLNRIMSTLTDSEIEKLFSGAPQYFARSEGHCSGAPNPSVAFPFDEALEIRDLTDHVQIEDRAWSGLTAWPHLTRDLNQDAAARAQAVDSRKAHFFIRCRERPNMLSMQGLEKGTMGFSAALELAVGDALEEEQFGFDSVGKKAHAIVEARERMLSSLGYLRRLPETELLDRLKRNAELYRVNDLRKKTSVQTYQDLFHTFMRPCNSVVDKRDHYSLTNQINALIKCLGTANVWFDFTHVEWRIRLGQILWGGEDNDELEDTSSIHDASSASERAEEKYWLLMQILVATELLIRLDAITEGEEYGVEAFRPVDVVHFERAATPMVKWSLHLARSWLDNIEIEKIKEDPPSDASETKGKVTPPPATGWLGALFSKFIVRQHHEDKTTASHTYTIKGRNPQQQVDGLTHFAKKLLWPNIDTYEGLIAKNARRSIINSVPKPAPVIASERSSKSSESNGSKRGLYFGAWDRPGSQKDKTRPQRRKLAAALHPSGWLSKSYIYGLVLPGDGMCHFLMATLLENDSKAMERLGSFANLCGGFVYSGKSFWSTSCIVGRVIAAGQGSAECMGWVSSDILPLGIDEGWVNIEVEEVAEDKAHLGKKARLWAKKRVERESSILGDADEYSVFPADFIIPHENNYSTPPPLISVTLRSLELLSPANSIQSTPFTKLTPGASVSNKEPELLSFPANVNFAVSIDGFTAENFSFSLLYDINFVTAHPCSPSHRVRFVKSPSSPTIQQIDVSGSDTFGQGHPLHKYYNYTVIHISELLKRQHAPLSELLAVPQTHRRSPSRMGSERVLVIDCITNLSEVPQSPTIERLTSKYNIVQRRGSFPAAEQMHFESRKRQFGSDMEILVRALCAQKGWNAIISRRKRGCLACAIREAGALQWKVIIRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8Z6</accession>
    <name>S0E8Z6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_06204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432331.1">
        <property type="nucleotide sequence ID" value="XM_023579503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8Z6"/>
    <dbReference type="STRING" id="1279085.S0E8Z6"/>
    <dbReference type="GeneID" id="35399681"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06204"/>
    <dbReference type="HOGENOM" id="CLU_000288_79_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990315">
        <property type="term" value="C:Mcs4 RR-MAPKKK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="266"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT70252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="654" mass="69774" checksum="91E675C73642473F" modified="2013-09-18" version="1">MSASDSIPATPEEWKDLSTPASPGSEDSSEPSTPLESPSHDSPSEPPRRVPSLRSVSDPRNMNPNSTAMGVLGMARRPVQTSSSFAGSSSASVENSIMAKARALHRQRMEKGMSPAGNPGTPSGSSPTASIANGFPTNLGLPPNMQRPHAPHVNSAPAITKPSLSERRAMGGGMGMKLSDMSRPSPVTASGKKRGPPGKLSDITGDAPGSQRSNGAGGGQGSKMDDFKKYIDTEKGWVTFDGAATITRTGVNFANGQTFSISLDEVEVLTELGKGNYGTVYKVKHAKRRVPRFGQGLSRKPLPVQYSQSDPSPVRSAEDSAEGLSETTDGTTGTVMAMKEMRLELDDAKFTTILKELVILHECVSPYIIEFYGAFFQEGAVYMCIEYMDGGSIDKLYNGGIPENVLRKITYSTVMGLKSLKEEHSIIHRDVKPTNILVNTRGQVKICDFGVSGNLVASIARTNIGCQSYMAPERISGGGFAQAGNSDGSYSVQSDVWSLGLTIIECAKGAYPYPPEVSSTIFSQLSAIVEGEPPAMPEDTYSEMAKDFVKSCLHKIPMKRPTYAMLLKHPWLVEFTKPQTITEEAEEGDGVDTVAEAVGKINLNSSTADAEVAAWVNGVLQREKDGLKEDGLLKPALHNAPLDSVSPMSSPKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9B8</accession>
    <name>S0E9B8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to nucleoside-diphosphate-sugar epimerases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433570.1">
        <property type="nucleotide sequence ID" value="XM_023580873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9B8"/>
    <dbReference type="STRING" id="1279085.S0E9B8"/>
    <dbReference type="GeneID" id="35401904"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08428"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="308" mass="34314" checksum="B6C214CF2C36871D" modified="2013-09-18" version="1">MAAIEYFLIAGATGRQGGATVDALLTHPDIKIKPKQVYALTRQASGSGAVKLREKYGDINIVAGDLNNPEAILQQLDKTILPKTGIFLAQAHGPTEVSDAKGLIDSAARNGILYFVYSSVDRGGRELSDKDPSYCKTFSDKFLIEKHLIDTWSNSKMDYTILRPTWFADNAWWGFPGQLCMTGWRDNMAGKKMQVTVTKDIGRWAVEGLVRPDRTKIRNQALSIASEELSFKDIDGIFIKHTGNGVPVSYGLLTRFIIWMIKDLNTMFGFIGERPYGADLAWLKTQLEPTTFEQWVKTDVPGRDNTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9I7</accession>
    <name>S0E9I7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to anaphase promoting complex subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_08388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433608.1">
        <property type="nucleotide sequence ID" value="XM_023580918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9I7"/>
    <dbReference type="STRING" id="1279085.S0E9I7"/>
    <dbReference type="GeneID" id="35401864"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08388"/>
    <dbReference type="HOGENOM" id="CLU_039415_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DOC" evidence="8">
        <location>
            <begin position="419"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT71529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="648" mass="71953" checksum="9350E3E9CDECD222" modified="2013-09-18" version="1">MDITRGSRRARHVAATHANPNNNTNARAQAQANRASSPRPVPSDITSSPVPQAPAATPSGPSTRLHPSQGASPLAAAPMVTPDGPPVHRTPDQPPDQRRRRAPPPNPFRLYRMFAAVVGCHWSSATYRRLPPTDAFISLLLLYLLFFFFFNTRSTLHTPSRIIISPHIPIANSSNKYLVNPLSLSPSFLSSGTFICCSQLDHSFITELVPPLSEQTIPSLNMPSRRDIYIPPPPASTHRINRDHRIKRVPLQDLAFKKSSGALLQQRKRVFRTVPSPDKENVEACYRAIDHLSVTFEEWYQERMRLLRESRELRTSINNILLAAQQPTDRSRLSMPPRDSDASSSDAEPDESILFNRARPMAAPAGPSSDATMANNDDQAAEDDVDQRTLSHSPEEYEDENSIDEEEEEEVDEDEDDEEAAEHDQAHEAATLFDPATAGLKEISNLARFTVSSHKPGNGVEELKSDDLKLFWQSDGPQPHKLTMYFTKRVGIRDIRFYVDYNEDESYTPTKVVFKAGTSENNLIEFATMALENPSGWQQVPIAGAGGGPDGNTLVAWVVQMQILENHQNGKDTHLRGIKIYSFDNDSALGPGRDGNPVEDVLDLMDTATSHINPSSTRSRLSNFGASNFESAEGGLAIPEFMREPEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA58</accession>
    <name>S0EA58_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_07702</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="16"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431453.1">
        <property type="nucleotide sequence ID" value="XM_023577984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA58"/>
    <dbReference type="STRING" id="1279085.S0EA58"/>
    <dbReference type="GeneID" id="35401179"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07702"/>
    <dbReference type="HOGENOM" id="CLU_023894_0_1_1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 15" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="18">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT69373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="477" mass="50390" checksum="4023B179BB25D333" modified="2013-09-18" version="1">MLCGISGEAPQEPVVSKKSGVVYEKRLIDQYINEHGTEPDSGEALTADDLLPIHSSRIVRPRPPTLTSIPALLATFQNEWDALALETYNLKEQLARTREELATALYQHDAAVRVIARLTRERDEARDALSKVTVTGGAVDGDSMQVDSVEKLPEELVAKVDETHQTLSKGRKKRPVPEGWATGEEISAFESATTHSLPVPEATALTVGGTNAAAVGGLKGQAVVYSTTEDKVEQSLSVGEPVTDAVWAEAGVAFATGQGSIKVFQEGNQVASLSEHAGAATALSLHPGGEILASVGTDKSIVFYDLVAQKRVARAYTDAALTSCAFHPDGHLFAAGTTSGEIKLFMTNTLEQAASFSLGAPIQALSFSENGYWFAATAKGQTMVTIFDLRKEGDAAVAKVLETGGPVQSLAWDYSGQFLATGGAAGVTVQQFTKSSKKWTEPLKSSTPSVAVRWGESAKQLVTVNGEGVVSVLASTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA63</accession>
    <name>S0EA63_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable NADH dehydrogenase (Ubiquinone), 64 kD subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_07805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431458.1">
        <property type="nucleotide sequence ID" value="XM_023578098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA63"/>
    <dbReference type="STRING" id="1279085.S0EA63"/>
    <dbReference type="GeneID" id="35401282"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07805"/>
    <dbReference type="HOGENOM" id="CLU_021377_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000002">
        <property type="entry name" value="External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="539"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT69378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="693" mass="77589" checksum="D6051C06867C3BB6" modified="2013-09-18" version="1">MPVSSMMAARLARAGQNRAITSSRCFKPSLAPRPLYSSQSRSFVKLTGAWPSITKGSPATSRTTRQLPSQFFVRALSGKPLPQGKSKVVNFCYRLAAWVGISISVIGVGIVGFFIYDASTYCEHPTQSDIDVSKIALQPRSGGEKNLPIAEVFIDDDDSEEKRRLKDKPRLVILGGGWGGVALLKELNPEDYHVTVISPTNYFLFTPMLPSATVGTLELRSLVEPIRRILSRVNGHFIRAKAEDIDFSHKMVEVSQVDANGKDFKFYVPYDKLVVAVGSTTNPHGVKGLENAYFLKDINDARMIRNQVIQNFELANLPTCPDEERKRLLSFCVSGGGPTGVEFAAELFDLLNEDLTRHFPRLLRNEISVHLIQSRGHILNTYDETVSRYAEERFARDQVDVLTNSRVKEVLPDKIIFTQKQDDGTIITKELPIGFCLWSTGVSQTQFCQTLAAKLGKSQTNRHALETDTHLRLNGSPLGDVYAIGDCSTVQNNVADHVVTFLRSLAWKRGKDPETLQLSFADWRGVAEDVKKRFPQSINHLKRVDKLFEEFDKDKSGTLDFDELTQLLKQVDNKLTSLPATAQRAHQQGQYLARKFNKMARMHEGLNANDIREGDVDAAVYKAFEYKHLGSLAYVGNSAIFDLGEGRSLAGGLWAVYAWRSVYFAQSVSLRTRLLMAMDWTKRGLFGRDLMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAJ1</accession>
    <name>S0EAJ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to GNT1 alphaN-acetylglucosamine transferase K. lactis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433734.1">
        <property type="nucleotide sequence ID" value="XM_023581068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAJ1"/>
    <dbReference type="STRING" id="1279085.S0EAJ1"/>
    <dbReference type="GeneID" id="35401728"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08252"/>
    <dbReference type="HOGENOM" id="CLU_034860_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="435" mass="50480" checksum="1C95AD382D7602E9" modified="2013-09-18" version="1">MGVASTLMSRFCRILPPVTIITICFYFLIKLSLVSNAAVPDPERWKNHALDFVEEDEEGYTPTFETTAIPTPLQTSAAHIEDLENKGDIGDFADDDEFLPFVNIEDDGDWDEEDLQEMSGGKYENETVDDGGDWSRFAYIQYVTNEDYLCNSVMIFEALHRLGSKADRLLMYPQEMLDPEAEYSSSHGGKLLIRARDEYNVTLQPIEIQHRDGQDETWADSFTKLLAFNQTQYERVLSLDSDSTVLQHMDELFELPPCPVAMPRAYWLYNDNPPKKILSSQLMLIQPDEVEFERIVQKMNSIGPNDYDMEIVNSLYLDSALILPHRKYDMLTAEFRAKDHSAYLGSEREQWDPNAVLNEAKFVHFSDWPVPKPWINDPEVRLQNQPDCATNETTCAEREIWNGLYTDFRDNRERVCESFGTQKWIHWKRMAKRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAL2</accession>
    <name>S0EAL2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_08480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433997.1">
        <property type="nucleotide sequence ID" value="XM_023580814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAL2"/>
    <dbReference type="STRING" id="1279085.S0EAL2"/>
    <dbReference type="GeneID" id="35401956"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08480"/>
    <dbReference type="HOGENOM" id="CLU_031996_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT71919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="402" mass="46456" checksum="AE29D7D30913A64B" modified="2013-09-18" version="1">MSSHGIARAARSRTEEQRQQDLVRIQKYCGLEDDIRQQISDNNYGAETFQLTSKLLRLNPEYYTIWNARRRCLIYGLLSKPSAGSPHSKESQNTSAIGTHTASSDASLPSSSTEIPPRPAPPTAGKTGTTTDSDADTNVIRSELGFTVPLLMEFPKCYWIWNYRLWTLDRAIERLDVSIARHIWEEELGLVSKMLTKDRRNFHAWGYRRHVVAQLESSVLNGQSLVELEFEYTTKKIHEDLSNFSAWHNRSQLITRLLNERKADNASRKDLLDKEIELIREALNVGPEDQSLWYYHQFLVLNLANPSSTRQIAPNLTMEERKSYIYDEVTEIKDLLQDYKDIKWIYEALVEYAIAFNQLTGQPFEPESRSDVTSWLQILRKLDPKRNGRWSDLEKDLGSPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAR8</accession>
    <name>S0EAR8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to salicylate 1-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432936.1">
        <property type="nucleotide sequence ID" value="XM_023580100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAR8"/>
    <dbReference type="STRING" id="1279085.S0EAR8"/>
    <dbReference type="GeneID" id="35402597"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09123"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000201">
        <property type="entry name" value="Salicylate hydroxylase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="163"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT70857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="452" mass="49961" checksum="89D2A377B2F616A8" modified="2013-09-18" version="1">MIKDNAPTMPNWKRLNVGVIGGGIGGMSVAIALRRAGHDVTIYERSDFAGEVGASVSCAANGTRWLHEWDVDVAKGDPVVLKKLINRDWKTGEPVSVYDLDDYEKRWGFVYNMFHRQYMHAMLKDTAMGEGEGTPAKLLVNHKCSAIDFPTGTITFENGVTAKHDLIIGADGIGSAVRKILGINPEKKPSDQSCLHCNVTTEEAVKAGLVDYSQNSALEYWGGQEGKWDKIVLSPCNGGKLLSYYCFFPREQGDYTTQAWGSEDLPTEDLLKPYPELDRQVFGHLAIGKEIQPWRLWVHQPYPYIAKENVCLLGDAGHPMMPHQSQGACMAIEDAAALGILFSKRYFNGDVKQALSVYDKVRLPRATRVQAAAAKAAYNINERIGFSVNKDISTYKVENEKEVLTIEEMNTYDMYKDIEEKLAKAQGEKYAGGFLNGLPLGLELPNGVIVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBG5</accession>
    <name>S0EBG5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434063.1">
        <property type="nucleotide sequence ID" value="XM_023581353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBG5"/>
    <dbReference type="STRING" id="1279085.S0EBG5"/>
    <dbReference type="GeneID" id="35407475"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14021"/>
    <dbReference type="HOGENOM" id="CLU_664011_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="414" mass="44059" checksum="7C2A26D51EE49E0C" modified="2013-09-18" version="1">MKAKDDKGNSLSSGSVRVSASSSISIILNGRNHLLTTVPMWLDCDPAGNLDFIIPSVTKATKFWESFMAPEIAKLGAAMSQLGQDITILFMKNGSINGDDIIKVSKSIVKAGIASVRAIVIGLLRLVKVFVQKLSELGNAEINIPIVSWVYKKISLIIAIPTTIFAKLITGKAPPTFASMDAKLIEGLIEGKGVPDSTKTDWTIFCGEVVVGITLTSGAVSLIKLLYKSATQGLDDVLDELDEGPSSLFDVFGIVVDIIGSLMAIPEQNDMPRAAYRNAISAISCFRGFYHTFAFFVKGKSSVEKVVLVLDLLTVFANLGLSIAVGVEETKAADSWEGYDKDATETGFITSGLNTLAGVAYFTAFFFKTNPGISSASAAVMVGTVAAGAALEGMVFKLQYDKSRKIALPSPLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC39</accession>
    <name>S0EC39_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_08561</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433451.1">
        <property type="nucleotide sequence ID" value="XM_023580723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC39"/>
    <dbReference type="STRING" id="1279085.S0EC39"/>
    <dbReference type="GeneID" id="35402037"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08561"/>
    <dbReference type="HOGENOM" id="CLU_020279_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT71372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="609" mass="68956" checksum="BEBB94CA8C90F902" modified="2013-09-18" version="1">MPTISVDKYKLYEALGQKFTTEEFEDLCFEFGIELDEDTENDERPIVNGEQEPPQLKIEIPANRYDMLCFEGIVTNLNIFRGRIEPPKYRLVEPASGKLESITVKPEAEQVRPYVSGAILRNIKFDKSRYDSFISLQDKLHQNLARNRTLVSIGTHDYDTIQGPFTYEALPPKDIKFIPLNQTKEMDSAELMNFYENDKHLGRFLHIIRDSPVYPAIYDSNRVVCSLPPIINGDHSKISLDTTNVFIEITATDLTKLDIVTDIMVTMFSMYCSEPFTVEPVQINSDHNNQTRVTPNLKPRVAEVEIDYLNSCTGLSESPKSLCKLLSKMSYTSTPSTRDSNILEVAIPPTRADVLHQCDVMEDLAVCYGYNNLPRTAPSRSATVGAPLLVNKLSDIIRIEAAVAGWSEVMPLILCSHDENFAWLNRKDDGNTVVRLANPKTAEYQVVRSTLLPGLLKTIRENKGHSVPMKIFEVSDVVFKDESQERKARNERHFAAAWYGRTSGFEVVHGLLDRVLLMLRTAFLTHEEGLSGKSVDFEVKENPGKPDGYWIQELDDATFFAGHAASVYLRLGGKERRIGEFGILHPTVLEKFDLKYPVSTLEINLEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC45</accession>
    <name>S0EC45_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Alpha-galactosidase</fullName>
            <ecNumber evidence="4 8">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_13796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="4 8"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434278.1">
        <property type="nucleotide sequence ID" value="XM_023581603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC45"/>
    <dbReference type="STRING" id="1279085.S0EC45"/>
    <dbReference type="GeneID" id="35407250"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13796"/>
    <dbReference type="HOGENOM" id="CLU_013093_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485087" description="Alpha-galactosidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="10">
        <location>
            <begin position="338"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT72200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="409" mass="44768" checksum="D3A19314FE5329A7" modified="2013-09-18" version="1">MFFNTQSLGVVALAGLATAVPSRNHLQTREVGKLPALGWNGWNQGQCNAASEKVALATAKTFISLGLKDAGYQYVNIDDCWSTKQRDSKGNLVPDPAKWPRGIKPVADEIHAMGLKFGLYGDGGVKTCAGYPGSQGHEQQDANLLASWGVDYWKYDNCYTPCNTGNAADIQTCPNNQAPSSKPRYEKMRDLLRATGRDILYSLCNWGYDEVWTWGAQVGHMWRMSQDNWGKWADVVRIANQAAPILKYTVPGHYNDLDMMILANGALTPAEERTHFAIWCITKSPIILGTDMTKLNSDEVKLITNKGLLAVNQDSLSKPAVPFTPPNTPTKGSGEIYPYWSGPISTGTVVAIVASKGNLNTQLNLKDVPGLKDMEYSWTELLTGAKGKGKTVSANLQTHDVAVFRIDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECB0</accession>
    <name>S0ECB0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to ribosomal protein of the large subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433536.1">
        <property type="nucleotide sequence ID" value="XM_023580831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECB0"/>
    <dbReference type="STRING" id="1279085.S0ECB0"/>
    <dbReference type="GeneID" id="35401942"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08466"/>
    <dbReference type="HOGENOM" id="CLU_064548_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="317" mass="36161" checksum="991EE95DF68A3B76" modified="2013-09-18" version="1">MRLRTTTSQKSQLQKVIDIVDDQRISKGALRARKSPPASTPIEDQCLVYNWKIAIRDSITNIMASWAPARPALKALASLSTTTPARLFSTTLPQQTKTIKSHLLPNRLIPPYPYGERRVYKQSNKGLYGSARIRFGNTVAEKYNNKARRFWRPNVHVKVFRLPAIQANVKTRLTLRVLKTIRREGGLQEYLLKSKPARIKELGPGGWNLRWLLMQSKDIQKRFNEERIALGMPPKEIEDRDDIIQYALDFATPGPLSKRSQATLGELLAREFVLGDEDLADLEGIQELSDEDEALLFKQLDAEMEARKTRGEQKITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECG7</accession>
    <name>S0ECG7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432137.1">
        <property type="nucleotide sequence ID" value="XM_023579269.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0ECG7"/>
    <dbReference type="GeneID" id="35399472"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05994"/>
    <dbReference type="HOGENOM" id="CLU_002643_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1303"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1387"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1520" mass="163412" checksum="D5F716107B691052" modified="2013-09-18" version="1">MALSSQPLTRETANPNATTAAASAFLRRESTPSLSSAAAAAALKARPTTPTNVSQVQSKRVARRSASVSSTGSRDRRSRELHRSPSASSMTERTFRSPSPSPARVAAPQAQDVPPVPKIPQHEHNKTNPKSSTHKRATSLQTQHFQTASQKMKSGQAQGSWFGAATGNDLSNVRRAPVADKRASADLRPSSPNSINFSYPRSMTESPSPSSNAMVYDPNSRRMVPQAQLLMIDQTVRDASEKSVRKQKHDGSRTGTHLSKGTVGRLRGTAVEPASPPPKAVASPQSPSITSVATTQQPGHPEAELESDPESEPEAKREAKPDSNLPTGQALIQQEQEPGVETSRHPSQTVGVPPAVTKSEASVRKRPSVVHEDPELEEEPRAAVQPAPTNEYPMDGVDAIPVKSTSPPQHPSEAAPIPGPSETVRRSRVHSESPAHSPARTTHFAPKTDQLLVRHEPPPRSLSPRKSALKYSGPRDASPSEDGSDASAAWSGMAGREETELSRKKSVRVSFDDGNTAVIGGSIPSSDTDSPQIASPQSRKSWHSIIGRNKRDSVTLDEEETMTPRPALPSFGSIREKKVREPEERPLVRPMERSASPPATDSLPSESSHKAPAQELAQSSDLAIGSVLAQEQASRNEANTSRYREPLPPVVTSVDGQGYISNSDLSSDESESVVMPRSQASVDPVSETQTTISNPASPYESSSAKSSPSDNIPTISIIQPSPRIPDENQAESPQDFFDVPGGFPAGLTDASGEQAISEDAKVSSSEPRSSQSPKGADQPAPIATRRSFDSTSAVSSSSQMHDIQEESDESDGSSIYSDAYEDLSDMEGDGFLSLDAVVDSPVESAFSQKVFEKAIAKSKETNASQQSTAKTPSQKPLRTPSDWETAKAYWRSLSPKDRRQLEKEAMEESDEEDTPAEAVRRSKPKTKTQAKQKQKLAEEPIQEPLETSENASVSEKLRSSTRIYQIQPGTSWPRDEVEKPLVKTPVTEKAKQNGGAKLRKSMRASEATTVGHSEPAQTGGMRKSMRSGAAPSSPQNSHDGHLRKSLRQEPETTAGVAMRKSLRANGPAANGHNTAPTQRNGGRPTSYQPATTSEAVKSQRRAHSEDRGPTMRSTTKPTLTRRGSDSSESSFRRAKAGGGEGFGFRKTMRGSTREPAAAAPPPESARGSSRFSLRSLSPTGSAFRRNSNTSSPPPVMMGGRMRQSLRNESNDASSSRMRVSGFGRLSKGKKSKSGSRFDDSSDEDEGRPAFRSRFVDSSDEDTPSPLPKQKRVPKTMRSSASDNAAAAAMGVPPARAGVQDSPDLPDSDDEEEQPRENLASNGTAIAVPRATLNRSGSGRDAIAPQANSVEITGGRPGHKRRGSFMSSILRRKKDPADKISRSTSESASRRDTHLERGPQRLAFIRSNSESQAHSSRLHKRGANWPLQDHQNTHEEEDQLDDGSQNTYVVDEEKRPSTAGGLGPSSSSPTTKTGFLKRRSISQSQIGAANHGVSASIDGSEVGTPKKKKFGTLRRMFKLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECH5</accession>
    <name>S0ECH5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to RTT103 Regulator of Ty1 Transposition</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434423.1">
        <property type="nucleotide sequence ID" value="XM_023581779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECH5"/>
    <dbReference type="STRING" id="1279085.S0ECH5"/>
    <dbReference type="GeneID" id="35405658"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12202"/>
    <dbReference type="HOGENOM" id="CLU_042070_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17003">
        <property type="entry name" value="CID_Rtt103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000030">
        <property type="entry name" value="DUF618 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047883">
        <property type="entry name" value="Rtt103-like_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="405" mass="43560" checksum="C0FECFF28CA18D5F" modified="2013-09-18" version="1">MAYNDDSVLARLSSLNESHDSIATAAQWIMFHRRHAERTVQLWMQRLKDSSSTKRLSLIYLANEVAQQSKIRHKDDFIIAFAPVIAEAVSVAYKGAPAELQAKLKRVIDVWRDRSIFEAPIQSAIDARIGDLDKSRGMSKPGFGGSPFGSTSTATSIPSEFAPLVTAHQKVNKLSTPLKATITSADQEYEKQTDPSTPVPSAPVYAARLNGLLKTLANAESAVAECVKAREGLVSGLESLLNANRAALEDERSAAAQLTSRKAEIEDKKHQVEVGIMRALGPADSNGSPGQGDSSVTPPEPDRPEIEALTPPAFEPFEAPTPEALTPEGEPVAAPSISPDPVPAAATTTSQDKEEEEVPSYQSLPISTNGSNKRRRVDTEEFPDLGGDDGIDADVAEMLKEQPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECV7</accession>
    <name>S0ECV7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434792.1">
        <property type="nucleotide sequence ID" value="XM_023582233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECV7"/>
    <dbReference type="GeneID" id="35406063"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12607"/>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415:SF3">
        <property type="entry name" value="GNAT-FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415">
        <property type="entry name" value="SPERMIDINE N(1)-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="213" mass="24218" checksum="451C2B77EF2BBFF7" modified="2013-09-18" version="1">MDYSTKDIANAYQSKRLEYVRADKTDENFKKIALTILQDPVIQALSAPTMLLPKGPKEVDSYIDSVVNSLLGVAIYLRDDVGGDKTEDKDKKPPTIIGVMCIGWGGISPTVSHHRTAEIGISLVKEHQGKGYGREAINWMVDWGFRHAGLHTIGMTTTDYNPRGVYLYENIGFKLEGRRRQTVWMNRKWYDLIEFGMTEDEWESLRGLDTEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDL6</accession>
    <name>S0EDL6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to vegetatible incompatibility protein het-e-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434808.1">
        <property type="nucleotide sequence ID" value="XM_023582251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDL6"/>
    <dbReference type="STRING" id="1279085.S0EDL6"/>
    <dbReference type="GeneID" id="35406078"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12622"/>
    <dbReference type="HOGENOM" id="CLU_834318_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="333" mass="36782" checksum="2E33747FA7F4A00F" modified="2013-09-18" version="1">MLLSRRSHSAKLPWAFLGHQNERGIVSFSSDGTLVASLSSTSQVVKVWSTESYKCRHTLHFKTPIVHDQLALNKDWLVVGLNNYRTPVHDMKTGAVSKTVCSNFKAGPVISDDGTLLASHSLEGAVRIWDLTSMASTDSMTIEQSMGVELVTPFTDDKTILSHSRGKVEIWDMQSAVCKESLEPEVPSETQIFVAAATGAPVFAILKDTVVEIWDTNPLRHASTFQRTFSCLGERYYCLAISANGERLAVGSSKPGTVEIWDVKNAVLQHTLNVRLADFPCIAFSPDAAKIAYTLWGALKIRSLPRLETLTIKTNRKSFIRTLTFRGKRIIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>S0EED5</accession>
    <name>S0EED5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to PMR1-Ca++-transporting P-type ATPase located in Golgi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_09993</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435399.1">
        <property type="nucleotide sequence ID" value="XM_023568043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EED5"/>
    <dbReference type="STRING" id="1279085.S0EED5"/>
    <dbReference type="GeneID" id="35403460"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09993"/>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="854"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="882"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1030"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="109"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT73321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1099" mass="122463" checksum="F1B5976E88D2EC1F" modified="2013-09-18" version="1">MSDPDIRGTKESDPEAQIQRITFQDGPERGREDHDAHRLGRTLSRSLSRRRSHSSSRSRIHPTSPYSGVQIEYRTLSIQVTEAKQVEPTEDSKTAGGQKTDEDYFSKLQYHELQTEQLCQQLNVDVGAGLSESSAATRLERDGKNTLPHPKTNYIKRTLKYIFGGFCSVLWVGAIIFFLCWQPLSNPPSNQNLSLAVLILIVIFLQAGFSAFQDWSTAKTMNAILDLLPSFAMVKRDGELKSLPTVGLVAGDVVHLKVGDKVPADLRIVSHSGDIRFDRSVLTGESDEIEGAVDATDANFLESRNIAFMGTTVMNGNGIGVVILTGGRTVMGRIATSTSGVKDSAALIQREITRFVMIIVCMTIILALAILLTWVGWLRVDHKAYMSVPAMLVNVMACVVAFIPEGMPVAVALTLMMVARHMKAVNVLPKGLSTVETLGCVNVICSDKTGTLTQNQMFVSSVAFVDKQFDSSDEFQHLLHGKEVSEPATALQRAALLCNDASFDPTTNHLPLHERTIQGNATDSAVFRFAAYGPSGDSFRKTVPRIFEVPFNSKNKWMLTVFQSDDERGAYRVIIKGAPDILLAGCTKYWSSESNSVETLTRDARIKFQEIQDDASRRAERVIVLCEKFITPRAVAGTNSFSDEITHSAIQDLTVVGMLGIIDPHRPEIPATVEQCRRAGTRFFMVTGDYALTAAAIARNTGIFSCQQDPDTIDTLYTGNQITESEKPKRKARKGDRAEIIKRSLLLEGANLSRLSQEDWDVVCAYEEIVFARTTPEQKLRIVTELRERDNVVAVTGDGVNDAPALRAADVGVAIVTGSDVAIEASDLVLLDRFDSIIDAMRLGRLVFQNLQKVISYLLPAGSWSEIWPVILNVWFGVPLPLSAFLMIIICVFTDLFLSLSLIMEKEEFDLLSLPPRNHKRDHLINRKIYTQAYLFTGFMETITAHAMFFFYMWKYAKMPVSELFFLFEGYTEGYRGYTAAELTKFNNTGQCVYFVTLVFLQWGNILAVRNRRLSIFQASPLSKAHRNPWLILSMLISLCIAIFVTEVPGIQNLFDTESVPIEFWLIPIPLGLGILLVDEMRKFIVRKYPKSIVARIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEP8</accession>
    <name>S0EEP8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_12198</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434420.1">
        <property type="nucleotide sequence ID" value="XM_023581775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEP8"/>
    <dbReference type="STRING" id="1279085.S0EEP8"/>
    <dbReference type="GeneID" id="35405654"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12198"/>
    <dbReference type="HOGENOM" id="CLU_017171_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="281"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="445"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="567"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="495"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT72342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="790" mass="87232" checksum="2ACB43CDA5132880" modified="2013-09-18" version="1">MAAQGAGEHVYATLLLSDSYLPGALVLAHSLRDAGASRKLAVLVTLDTVSADSITQLKRVYDYIFPVPRIRNDHPANLYLMNRGDLHSAFTKINLWKLTQFSKIVYIDADVVAYRAPDELFDTPHPFAAAPDIGWPDLFNTGVMVLEPNMGDYYAMIAMAERGISFDGADQGLINMHFGQRYHRLSFTYNVTPSAHYQYVPAYRHFQSSINMVHFIGSNKPWFTGRDAPSGNNPFSEMIGRWWAVYDRHYRHQESSSGNASSTTPYVQYFTKGEWHPQLVHAQSSTSEHHRSVSAEGTHHSAPAHEHHASWEEQGSGHHQSEGSGPHEGSHHGGGYHDGSDSGSAHHDHHPAPPSGRPVSTPGHHHEQHHGQHASEHQHHHHKEPKNEPPQITMHDWDAQRHPPPADSKPEAMNFPSTHYEMSRDTAPFVPPERYPSPPKNMWYEVPKEKPAPRSKPAPEIFPWERNRPRPTRSFLGEPELPAPEPEPTPAESGSDPSTVPTTQLSVTTEGLTESSEVTASGSGSKNESNASTPIVQITPSDPWTSYTRTNAWDEVPEIERYVDRLHGGHRRGKSSTSTIGRVKSPSTGAWRDDRSTFKNRGLKLTDFPSATERPSLPVTPAPIHRHSFWAGDDGEHEDEAAKKLPEAEGVPTQSDWDPLAQLQKLAKQQSDALLKKLGGEGDEGREGGVSREIPTRSLPFGSGDAKSPTYVAQSAAGVLSPQPVKGERSAGILRDMSSGRLEPESTSQSTTIPEPSYTGPGAAWEKDEDIPQYETPVPPKEEELDALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF06</accession>
    <name>S0EF06_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to transporter protein HOL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433037.1">
        <property type="nucleotide sequence ID" value="XM_023580220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF06"/>
    <dbReference type="STRING" id="1279085.S0EF06"/>
    <dbReference type="GeneID" id="35402489"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09015"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT70958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="505" mass="54542" checksum="58A0E4F42DD1D2EC" modified="2013-09-18" version="1">MAFGVLESNASEQPAGTVFLEDSQDGMHTILVPAPSNSPHDPLNMSKIRKELYFLTLLFGACATGAVGPVLVPAFGIVSQTFQTPLSKVALLNGSLVLGMGVSCFFLAVVSDLWGRRIIFVVTSILLVVTHIWAAVSQGYESLLAARVFQGVAMGPFFSLAGTSCVNDVFFLHQRGRRVGLWNFAIIVSVNIAPVISGYLIVDMGWRWAFWFLAVAFAVGLAMVVFFLPETKWHRDEITSSVVGEEKTDEKAVRAEETPVEIALWRKICGVQHLQFASAKELLPGLARSILMLRHPAVVWGCVMWSMTFTWVIVLGAVADQIFGAPPYSLDATQVGLVIGIAPLVGSALGTLISGWMSDLAAHYMSAFNGGLYEPEFRLVVIVPSAITIAIGAFGLGDGIEHAKSTMVCCVHLALINFGVGAGCTGIVTYTNDVCMDRAGSAFGLAMLIKSSFAFGLTFMLNDYYATKGPMVFFSTWGGLTLGICLTTVPLYVFGKRIRSWMGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF17</accession>
    <name>S0EF17_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435619.1">
        <property type="nucleotide sequence ID" value="XM_023568416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF17"/>
    <dbReference type="GeneID" id="35403124"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09656"/>
    <dbReference type="HOGENOM" id="CLU_043410_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36864" checksum="A810A6BF59C13BB2" modified="2013-09-18" version="1">MLRTQKLSSALAKHARTFATVTQPPQVGVVRPSAQEVKNRTLDSRNLEKAVRHMHRDGLVIVEDVVPHTDIDTLNKKMIEDAHTLQARGDKGPFNYNKGNIQQDAPPVSEYFSPSIFINPIATQITTAMMGPRPKWTFCSANSAMATLPGGTPQRQPVHSDADFAHPDHPFALVVNIPLVTTTPENGSTEIWLGTHNGFGLDAQDCAHGERASGRIREELLRQRQEVSPPLQPVIKKGSIVVRDLRLWHAGMPNTTQQTRVMLAMIHFAPWFRNRMRLELGEDIKPFLEGLEKEGRLGLDVPVDWASREAVLESYLNRGFGNSYDFSQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF53</accession>
    <name>S0EF53_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435664.1">
        <property type="nucleotide sequence ID" value="XM_023568469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF53"/>
    <dbReference type="STRING" id="1279085.S0EF53"/>
    <dbReference type="GeneID" id="35403077"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09609"/>
    <dbReference type="HOGENOM" id="CLU_052989_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="32841" checksum="EBB13F573A0F68DB" modified="2013-09-18" version="1">MSNARTIFQLNSQPTWFENISLRPRGTILATRLDVPEVWEIDPEKSTGSKILRVLLPDDIPNPVLTGICCLKPDVFAVAAGSFDMLGGAKSKPGSWSIWVADLAGEQAKVTKIADMPEIGMINGIATWDENTALITDCLYGKVYKLSVATGSYNVTLEDDTFTIPADAPFQVGLNGIKVHRFAEQTYVYYTTTSRFCVYRVPVTQQVQAEGPIETLAPGLVADDFALACDGTMYVCTNISNTVVRIPATGGKAVVVAGEAKAFDVAGSTACVFGEDEGVLYISTSGANAVPVDGKTEPAKIVEVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFQ6</accession>
    <name>S0EFQ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435914.1">
        <property type="nucleotide sequence ID" value="XM_023568769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFQ6"/>
    <dbReference type="STRING" id="1279085.S0EFQ6"/>
    <dbReference type="GeneID" id="35402809"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09340"/>
    <dbReference type="HOGENOM" id="CLU_034859_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="49879" checksum="71CD5E1E364B8B45" modified="2013-09-18" version="1">MEAPIMMKQYDTAPKAALPHDLPPTELSVPGPDSVTLAKKHSQWSCIDDNRLRNNLFAAVGFLELANAGDFAANVWNDVPVPIYAIVFMAIGGTSAFVLSICAFFDSRKAWRNIKFLRQQKQYLETEKENLPAGADSRGLDVFIEITTRELRIEIINRWAMDLLMGGGAMLISIGTFMAIGGANRKVWHASNILSGYLGNAPIALFGLISAIWASMVVSKMRSHVTVAKKELQGSPSLPLLKQRCFNVQLFFILNGIANVLGGVGSMITAERWWGYCILIPVIVTSIFCNVWWRHRVGYDRPCISAIPPLTVDNITEALESTSQLRHTIQGGAGVDLEQIFGEEVTLQDVLELFVKHDLFEQFSLRLVANNKIGHLFVKTQELRVQVSVASILDLSEEHHPLILAAALRFLKKQGPKHLLHRERFLVEVLGTYLHQQKKSQTVEVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFW4</accession>
    <name>S0EFW4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable transitional endoplasmic reticulum ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_08663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433357.1">
        <property type="nucleotide sequence ID" value="XM_023580610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFW4"/>
    <dbReference type="STRING" id="1279085.S0EFW4"/>
    <dbReference type="GeneID" id="35402139"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08663"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="143"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="255"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="529"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="801"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="736"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT71278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="821" mass="90234" checksum="13338561AF72DD3F" modified="2013-09-18" version="1">MAPQPDEHHPHKKVNLTDPSGAEVKNEDDVATAILKKKKKPNQLMVTDAVNDDNSIIALSEATMDQLQLFRGDTVLVRGKKRKDTVLIVLADEELDDGSARINRVVRHNLRVKHGDMITIHPCPDIKYAKRIAVLPIADTVEGITGSLFDVFLAPYFREAYRPVRQGDLFIVRGGMRQVEFKVVEVDPPEYGIVAQDTVIHCEGEPIQRDEEENNLNEVGYDDIGGCRKQMAQIREMVELPLRHPQLFKSIGIKPPRGVLLYGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKREKTNGEVERRVVSQLLTLMDGMKARSNVVVMAATNRPNSIDPALRRFGRFDREVDIGIPDPTGRLEILQIHTKNMKLGDDVDLEQIASETHGYVGSDVAALCSEAAMQQIREKMDLIDLDEDTIDAEVLDSLGVTMENFRFALGVSNPSALREVAVVEVPNVRWEDIGGLEEVKQDLKENVQYPVDHPEKYLKFGMSPSRGVLFFGPPGTGKTMLAKAVANECAANFISVKGPELLSMWFGESESNIRDIFDKARAAAPCVVFLDELDSIAKARGGSMGDAGGASDRVVNQLLTEMDGMTSKKNVFVIGATNRPEQLDPALCRPGRLDSLIYVPLPDEPGRLSIIKAQLRKTPIASDIDFGYIASKTHGFSGADIGFITQRAVKIAIKESIAADIERQKAREAAGDEMDTDEDAEDPVPELTKAHFEEAMQMARRSVSDVEIRRYEAFAQQMKNAGPGAFFKFPEAGAEAAGADGGNSFGDAGNDDDLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGP8</accession>
    <name>S0EGP8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436279.1">
        <property type="nucleotide sequence ID" value="XM_023569004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGP8"/>
    <dbReference type="STRING" id="1279085.S0EGP8"/>
    <dbReference type="GeneID" id="35403708"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10243"/>
    <dbReference type="HOGENOM" id="CLU_381318_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="726" mass="80318" checksum="345AEA99FC574CC3" modified="2013-09-18" version="1">MYPLNLEPYAAGGHCAVAICLGETPLIDPDNVCDLVKSLQEKFTDIAFLICDEIHNGQLSSNLTILRWSQIEDQDYQKVYDIMYQYRKNFDEELRASSGFYIKRRLALMGFNYDNRQYTTIFHPVYPRKNPDGSAGNVNSAYVSPIDTVVQAYRNNSDVVGDISRSVPHMEAGKVRRVFFDRPVPEEVKEKLCANGLDAPLLNLLEGWAFDDQLIGYDDEETFADKKAWAGGYCFGGTMIWSIDFQPSDNSTDGYVPALPDLDGIGAIPKDLQDKVLKKCDTGFSYDNYGDLPKLWYDSGAEQWADAYIKSQKDHTNWAQNLYRNLFEKKDHTKFSCVTPNSQCDFEASCAEFNKVGKGGLYYLFQSMSSFHTFMKALNQQYDSKITLPLAAASEMRLILDIKSGLPQTTINIGSVLGSAFSMANAIAAPLPGVGGPLAGISGLASMIRTFTSTVGGNDNAVDATDTLTFAVKTAAVERKRKIADIVSSVYGDFGYAQADLPKTILLGGADNPAIKVFGYGAWLRDSDLTDLSGAVERMSDKMNQALLWQMAIFFKGFYVVIRDDLPINRCTHPNNTWDDRTNRCVDILSWWPKSASGRVGSDLAMEKVWAKWNMSPLWTLLNAVECWENNGGKIGDAKVKALQSEWANGVPLPCFFAMPVLKGNWSKDAASDGATWLAGDFVGQEGQDGRLWPKGKCDKANKELDPITGGQVKKCSSLNKVGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGX6</accession>
    <name>S0EGX6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to monophenol monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_14012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435140.1">
        <property type="nucleotide sequence ID" value="XM_023581363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGX6"/>
    <dbReference type="STRING" id="1279085.S0EGX6"/>
    <dbReference type="GeneID" id="35407466"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14012"/>
    <dbReference type="HOGENOM" id="CLU_035914_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485923" evidence="3">
        <location>
            <begin position="21"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT73062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="353" mass="39487" checksum="9FECF8F0B015F607" modified="2013-09-18" version="1">MHVASLLATALLVAVPGSCALTHDCGCKAPLVRKEWRTLSTKEKHDYIGAVKCLATKPSQTGNIYAGAKSRYDDFQVSHIVNTDFIHYVGFFQAWHRMFIAQYEKDLRDLCCYSGGQPYWDWTLDSNSMEDFESSPIFDAETGFGGNGVFIDISGWTNVTRQVSGRTGGGCVTDGPFAKGQFEVHAGPDNSTAYKPRCLARDISVEYGISKLNQTVVDGTLEAKDFFEFDQRVQGGVSSESQGYHGGGHLAIGGSLGEMGDMYSSPGDPIFWLHHTNVDRLWDIWQRLDWPARKSDISGPDTQYAYPYDFFGDKAYKNITLAYVMDFGNLLPDRRYVTVEEAMDTRRLCYTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHR8</accession>
    <name>S0EHR8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436407.1">
        <property type="nucleotide sequence ID" value="XM_023569154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHR8"/>
    <dbReference type="GeneID" id="35403842"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10377"/>
    <dbReference type="HOGENOM" id="CLU_088295_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050680">
        <property type="entry name" value="YpeA/RimI_acetyltransf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420:SF44">
        <property type="entry name" value="ACETYLTRANSFERASE YPEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="183" mass="20435" checksum="CF2761595AE8505D" modified="2013-09-18" version="1">MTKPQIVVRIPPTSDAEDKTLVSTLTDIVNIAYMKAESDIFIPSYQRTSTAEITKFLSNGQLAVAYLQPNDEPIGCVFIKLITSTLGEFGMLALDPQYQGTGAGRQLAVFAEDECRRRGCTTMQLEILVPMTFHHEGKARLLGWYTRMGYELVKLGDFADDYPDLVNLLAGPTEYRVFEKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EII5</accession>
    <name>S0EII5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436528.1">
        <property type="nucleotide sequence ID" value="XM_023569293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EII5"/>
    <dbReference type="STRING" id="1279085.S0EII5"/>
    <dbReference type="GeneID" id="35403967"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10503"/>
    <dbReference type="HOGENOM" id="CLU_033263_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459:SF1">
        <property type="entry name" value="FATTY ACID DESATURASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459">
        <property type="entry name" value="ORF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="129"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="421" mass="49291" checksum="625C06353B2C2270" modified="2013-09-18" version="1">MEDTIVFHPQLTKADALILEGLRQDIKDSSSSNAETTTSAPTARDEELLRHLQAMNDPQDAHFEPSVTTNWDIDQIKLPLFLEKTVLRPYIRLARSVVRVETDVIMLTHLLLYFSTTIPSAIFLFTNFTWIHGVLHFVMQFSYMGAYTLLMHQHIHMRGVLDKKFAVFDHLFPYILDPLMGHTWNSYFYHHVKHHHVEGNGPNDLSSTIRYQRDSLVHFLHYVGRFFFLVWADLPIYFIRNGKVMTGLKAGFWEFSNYAFLITMFNLHRNATICVFLMPLLLLRLGLMAGNWGQHAFVDDVDPDSDYRSSITLIDVASNRFCYNDGYHTSHHLNPLRHWREHPVSFQKTKHTYASQHALVFHDIDYMMVTVRLMMKDYKTLARCLVPMGKQIAMSLDERAAMLETKTRRFTEEEIQKKFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIK0</accession>
    <name>S0EIK0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable NADPH2 dehydrogenase chain OYE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436919.1">
        <property type="nucleotide sequence ID" value="XM_023569749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIK0"/>
    <dbReference type="STRING" id="1279085.S0EIK0"/>
    <dbReference type="GeneID" id="35404376"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10912"/>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="350" mass="39297" checksum="BAD96A41B06029DD" modified="2013-09-18" version="1">MAPMTRLRADENHAPLDMMRDYYAQRASVPGTLLITEATFVSAKSRGRDENAPGIFTLEQVEAWRHVTDEVHSKGSFIFMQLWHVGRAARQHALDKAGLEMVSSSDVPISEEYPTPRPMTTEEIWECIASFASAARNAIDAGFDGVEIHAANGYLIDQFTQDTCNRRTDEWGGSIENRSRFCLEIAKAVSKEIGPARTAIRLSPFSTFQGMRMHEPEPQFSYLISELKPLGLAYLHLIEPRIAGNVDREADDQESLDFALDAWAWVGPVILAGGYIAEKANKALETTFKDRPVTFAFGRHFISNPDLPLRLARNIPLAPYQRDTFYKVKSTDGYTDYPFSDGWKEGQTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ08</accession>
    <name>S0EJ08_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to Ribosyldihydronicotinamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)H dehydrogenase (quinone) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436847.1">
        <property type="nucleotide sequence ID" value="XM_023569667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ08"/>
    <dbReference type="STRING" id="1279085.S0EJ08"/>
    <dbReference type="GeneID" id="35404302"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10838"/>
    <dbReference type="HOGENOM" id="CLU_058643_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051545">
        <property type="entry name" value="NAD(P)H_dehydrogenase_qn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204">
        <property type="entry name" value="NAD P H OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204:SF34">
        <property type="entry name" value="NAD(P)H DEHYDROGENASE [QUINONE] 1 ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like fold" evidence="3">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="261" mass="29771" checksum="7B0E971FA302C1A6" modified="2013-09-18" version="1">MKIFIVLAHPEPRSFNGSLFQVSVNELKAQGHQVKTSDLYSMEWKAKVDRSDFPNLVSDARLKVAYASRDSYTAGNLTEDVRTEQEKLLWADVVLFHFPLWWYTMPAILKGWVERVFSMGFAYGYGEHSDKHYGDRYGEGVFAGKRAMLIVTVGGKKEHFSTRGVAGHIDDLLFPINHGVLYYPGFQVLPSHVVYQTDRLDQTGFEKEAEMLRERLRHLDTIEPIAYRPQNGGDYEIPNLTLKPGLEGKNAKGFSIHIRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJA0</accession>
    <name>S0EJA0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to alpha-L-rhamnosidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436020.1">
        <property type="nucleotide sequence ID" value="XM_023568900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJA0"/>
    <dbReference type="STRING" id="1279085.S0EJA0"/>
    <dbReference type="GeneID" id="35402692"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09223"/>
    <dbReference type="HOGENOM" id="CLU_007933_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF4">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="1">
        <location>
            <begin position="384"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="2">
        <location>
            <begin position="716"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="807" mass="88812" checksum="04F60079D3550FE5" modified="2013-09-18" version="1">MENSRETRNAPKFVTPKRILRTSGNVTSQNEISSFSLSNDDSEDKAEVILDYGRCEGGFPIFTIESASAPERQKQVAFQVTYSETIEGMGSENGDGPFFLFSNAMDSYRVCRHHATVTNDTQSVKPRFNQASQRYQRITLLDPNTSIAFSKVGFQAVRPDAPVKANFHCSDETINRIWNDGVRTVDLCTVAREETVPVWDVTAEGTRVYGSHWAPCRQGTRWRDYKVTFQAKVEEHGASWAVRMITNGLIFCLDRRSRTLTAVEGLSNKSSILPSIERGSWQLPESIDLSGWLNIETLAVEDRVAVTIEGHKIATIRDIYVKAMLGNGLVNTGSVAFGGPPGWIALYRDLSVADNDGQILYDNSMLQPDASRTFDDFQVGTNKLACIIDGAKRDRASFGGDAFVTGRSIAYSTADFEAWKGTIQLLLSHQNKEGYLGNLCPIQAPEHDGADDPPHYGHYSMTYALLLVVSIKDYWLHSGDWSLVEKSYHQLERQMEFTKGFLNSDGLVQASPYLSMTWFPMGGPVFGVSAGLNLAYLDALNAIASMSRGSEATFQYSSQAANLKEALIRMLWNDERGTMRPALSLDNNGVFQDVNAYAATLGVSPDHPELVEGIFPASRSLPATFRGLGKWDKFGLASPYASGFALEALFVKNEGTKARELLSQVWGVMADQGNPNYSGAHWEAMRTDGSPFNHDVSLAHGWSSWPVFLLPRYLAGVYPLEAGWKRIGVEPVLADLEEVAYSLETPQGSFLVVVNIDEKQGQGSIKLLVPRGSTAVVKAPKGWILENDGVIQGSGTEISVKLSNCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJU5</accession>
    <name>S0EJU5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to pisatin demethylase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_12551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434741.1">
        <property type="nucleotide sequence ID" value="XM_023582170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJU5"/>
    <dbReference type="STRING" id="1279085.S0EJU5"/>
    <dbReference type="GeneID" id="35406007"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12551"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT72663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="521" mass="59364" checksum="BB4194F95EBCEAB2" modified="2013-09-18" version="1">MAILPIAAAVLAVVLFVKHIFLDPLILSPLRSVPGPKSFAATKWRLAYEDWKGTRTRTIFKLHQQYGPVVRIGPHEVSFNSLSALRTIYGPGSRYGRTTFYRMFDVYGEQNLFTFHSPKEHGDRKKLLSHAYSKSVVLKPPTAKMVERRVRQYLDLIEAEPENVSEIFSTLHYYSLDNITAFVYGKYGQTAAIRGSKIHRELIADILHPSRRKLSWSIVHLRTLTQWLYRQSGVMGQLVKPVLPMQQPTTYTGIRGYALRAFEAFRADVEKITHSEDEHVSIVENLWQHHESQKPGGLRDLQMASECADHFLAGIDTTSDTLMFLVWALSLPGNEKYQEKLREEVMAISGDGLNQWGNPRAEASDRCTYINAVIKETLRLYAPLPSTEPRSIDIDSVIDGYTIPGNTVVGMSPWIMHRNESVFKDPLVFNPDRWLGSDAAELNRWFWGFSSGGRMCVGMHLAMAEMTTLTATMYRQFRTTIAPGFEDTTPAITARVETFYDDRFPKVQESKCLIKFTKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK30</accession>
    <name>S0EK30_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to glutamine rich protein, nitrogen starvation-induced</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437207.1">
        <property type="nucleotide sequence ID" value="XM_023569286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK30"/>
    <dbReference type="GeneID" id="35403960"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10496"/>
    <dbReference type="HOGENOM" id="CLU_1102815_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="229" mass="22859" checksum="44C629BBBD7EE9C4" modified="2013-09-18" version="1">MSAQDYYGGGGGGYGQQQQQGGGSNHGSNQPSYDNRDQSYGQHQGGQYGGGPGQYPDGAGGPGGPGGPGGPDGERGLGATLAGGGAAGWAAHTAGSGLLGSLASAAAGAIGANFLEHKFKKHKKEKNRKHHRDGRPRAFTGDSTSSSDSDSGDERRRRKDDDLAYGKSQYDNSSRHGHGGGSHGGSSSYGGGGYGGRDQGYGGGRSYGGQGGYGGQGGYGQQGYGGTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK54</accession>
    <name>S0EK54_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434851.1">
        <property type="nucleotide sequence ID" value="XM_023582298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK54"/>
    <dbReference type="STRING" id="1279085.S0EK54"/>
    <dbReference type="GeneID" id="35406121"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12665"/>
    <dbReference type="HOGENOM" id="CLU_090389_14_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050620">
        <property type="entry name" value="Thioredoxin_H-type-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438:SF405">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="116" mass="13379" checksum="3C57469741895B8E" modified="2013-09-18" version="1">MPVIEIKSQEDYEKLRKKYKVVIINANASWAGPCKAMSPIYDRLSNQIPYNPELFVLAKLDIDDVPDLAEKLDVQGVPFFMIYENGKRKESFLMPSPTTLQKFLIMWSDKAHELGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKW0</accession>
    <name>S0EKW0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437684.1">
        <property type="nucleotide sequence ID" value="XM_023570594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKW0"/>
    <dbReference type="STRING" id="1279085.S0EKW0"/>
    <dbReference type="GeneID" id="35405131"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11670"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF147">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="41"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="425" mass="49133" checksum="FDBABB46F7FDE469" modified="2013-09-18" version="1">MKLRLRDDQDDGPVHTFVNPYVELNAGLWSLFAGATFFLWLRLYVKITRRHGMWYDDYILLVSWFILLANNSLIVWEFGNGYVLKDSSQQWDDKMHILINISSCGTLIGQALTKTAFAVTLLRMSNRWQKWILWFCIASMNAYMIVKVFFQWAKVCGKETYDNWYRFDFCLDSKFRNDFKEGGNIYNIIMDFVFACFPWLITRGLEMKKAEKIGLCFTMSLGMIIAIVSAIRVSWKDQGNGRDAYYIWRNGMSQIWYSSEVAGTIMVQCIPILRPILKKFHTSYTSRRLDSQTGERKGSGWTWTRSSKHISTGPLTPGHPPILNNNPDGMELRNIPEEQEPAEFDFWGKNDPPSPDDLEDGRPDIKYKFNREEMKFTRDDSWPLGGESESAKSARSIELAHSNMGLAVEHEAAQQGLSPPPPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKZ8</accession>
    <name>S0EKZ8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437363.1">
        <property type="nucleotide sequence ID" value="XM_023570221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKZ8"/>
    <dbReference type="STRING" id="1279085.S0EKZ8"/>
    <dbReference type="GeneID" id="35404796"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11334"/>
    <dbReference type="HOGENOM" id="CLU_023526_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="793" mass="87974" checksum="2228E8B54FE4259E" modified="2013-09-18" version="1">MAWLHPSFVNAIFPQTYFQPFIMYGPAPHRPSKTGARRSKSGCVSCRKKRRKCDESKPRCNRCLSANIECSYNTRVEFRDATVWAAQKVKRRIIHGPKEHGSPTPPESQNRHWPRFQPSPPSECDMVNNNDIPASAGEVTDSPNNHVEGNDVHQKQDTDLDGHVASDDIHKRQPDRGQTVQPAELTPSDRPLLGLTSPSTDTDIAAWMPTGVISSSWDDYVSSDMLTGDMLQYMPDQGALDINLEPCYNEMWCSLMESPSRVEPDSTASIPSTSTFESATGQEGQLDSVNSPSDAVTKTSVPILKQTIWTAPLPSSMPNIPVRDRVYLAHFMSQMIDLIPGLKYLGKIAIQSEPIRLCANALAAANLANRGGRFSKDEAGRWVPMQTHYGRALSFASRSMDAIQSSPGIFPGCRIVMLILMLCYQLELGCIGEIYHALSVLDSAVFSNRDAILSLEFGPGLVQSWLGLRSLCEGTLQPLALFRGESQTEHEVSELQDLTTGTSQAFGIIAAKAYRISRRILLFRCTGDNEKSPSTIASRFSQWWSIIKCQEADDITGTHDLGSHLSEDKLFCELARLRDALDISEVPTGLPLNFDPSVPASCTTTPEPLYLADHEQAMELADYASAQIVCDESNIQTLGSPAFQRSPSRNPWLHLLLRIAAGLDVEKCLTRNRYRQGICNSLQCAVFLLQDLEAAYFLSGLLQRLMDVGGSYEDCFTPLNLLSQCNKLFCQELMKGRTVFMLCPTYNAWTAKDVLFSRGDHECFIIFGRDADGLYLKDMVELEESPTGNLDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELS6</accession>
    <name>S0ELS6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435426.1">
        <property type="nucleotide sequence ID" value="XM_023568072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELS6"/>
    <dbReference type="STRING" id="1279085.S0ELS6"/>
    <dbReference type="GeneID" id="35403433"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09966"/>
    <dbReference type="HOGENOM" id="CLU_035622_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="267"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="436" mass="46338" checksum="F00B6826CA27BD14" modified="2013-09-18" version="1">MSERDDDVTPQRKRIAVACGRCRKRKIRCSGDAGNGESCTNCKNAGHEPCQFLRVASHEASIVKSEGFTYSLEASRQYQARGSSAISSLPSTAPAYADGVSSYTSDPFVYRAPTTYGYGAKPYCPLATWGHGYADDQSYYNSMYQAPYSSVHDSEYAISHRIASGTPGKSALCVDMEPNYAYSGPNSATSLVHRPAPVTTDSANLSYQTMMPDSTKSLGYQNLPTDSKSLGFQNMAASVNMGDRLLPAPVARTALPNSMGSSYKNDSGSSIYGSSSSKSSQASTSDTSPVSSTSEAPSSYTSYESSSMSSTSGCLPSYPTNLASQYGRQSNDYYSYTNSSDAPVLGPADSMRQGPEMTYRYIDTTNSVTAAPPTTARRDMPTLNSGGISSFPLGHSNSHYMTHQSAAYMMPPGDLGSVGADAAADSYRKATGTLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELX9</accession>
    <name>S0ELX9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable brt1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435481.1">
        <property type="nucleotide sequence ID" value="XM_023568136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELX9"/>
    <dbReference type="STRING" id="1279085.S0ELX9"/>
    <dbReference type="GeneID" id="35403376"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09909"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="135" mass="14410" checksum="D3532668EBA3EC53" modified="2013-09-18" version="1">MALRTGVLTTDAPAPSPHLSQAIIHNGTVYCSGSFGLDPQTRQLAEGPYHQTAGALKNLDAILNKAGTSLHNALKVTIFILNMDHYAAVNRAYLEFFTSDPKPSRTCVAVAQLPLKGAHVEMEAIAAIPEKSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMC2</accession>
    <name>S0EMC2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to members of the aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435601.1">
        <property type="nucleotide sequence ID" value="XM_023568397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMC2"/>
    <dbReference type="STRING" id="1279085.S0EMC2"/>
    <dbReference type="GeneID" id="35403142"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09674"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="332" mass="37367" checksum="AD2ED4737654C6A0" modified="2013-09-18" version="1">MSFGRTVTLNSGHKMPQIGYGTWQAAPGEVGNGVYEALKAGYRHLDLAKIYQNQREVGEGIKKALNDVPGLKREDIFITGKLWNNKHRPEEVAGALDDSLEELGLDYLDLWLIHWPVAFKNGPELFPLKADDKNKTELDQGVTLSQTWEAVTKLPKEKVRSIGVSNFSIEMLETIIKDTGVTPAINQVERHPRLPQPELVKYLKEKGIYLTAYSAFGNNSWGEPLLINTPEVKAIAERLSKSKGKEVTPAQVILAWSTLDNHIVIPKSVTPARIRSNFEEVELDDEAIKELEKFGDKPQRFNIPKTYSPDWDIDVFGDEKEKTATHKVVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMN0</accession>
    <name>S0EMN0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to PRC1-carboxypeptidase y, serine-type protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435726.1">
        <property type="nucleotide sequence ID" value="XM_023568544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMN0"/>
    <dbReference type="STRING" id="1279085.S0EMN0"/>
    <dbReference type="MEROPS" id="S10.008"/>
    <dbReference type="GeneID" id="35403010"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09542"/>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF453">
        <property type="entry name" value="S1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496247" evidence="6">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="477" mass="53527" checksum="E6AA3DAAB9917182" modified="2013-09-18" version="1">MRFSSISTVLLGLIGSVSAFGGIAPDSRQFRTLERHGLTVFKHAATGSKLEYVTNSGICETTPGVGQYSGYLSVGKNHSMWFWFFEARHNAEKAPLAIWLNGGPGCSSMIGLFTEHGPCHFVNNDTEPSLNPHSWNEYANMLYIDQPIGTGFSVGTEDVNSTAQAAPYIWKFMQVFLDRFPKYKSREFGLFTQSYGGHYGPEFADYFLKKNDQIEKGDAEGHKVDMVALGINNGWIDPKRQFKSYATYANRNPYKQILNNKLFTRFIDAYNKYCLPVINNCTQLEGQDDECAEADDACNTQMYTNLEIAGRTDFNVYDVRIGRDDVDPPETFLEYLTRAEVMDAIGANTRFAECSDTVYANMATTGDGARSYVGPLADVVKRGINTLLWAGDTDWICNWEGVLWASYALEWPGQKKFVAAPFSNYTINGTAHGRYKTVENLSFLKVWEAGHSVPYYQPETALQVFKQVMQKKPIKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN84</accession>
    <name>S0EN84_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438183.1">
        <property type="nucleotide sequence ID" value="XM_023571121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN84"/>
    <dbReference type="STRING" id="1279085.S0EN84"/>
    <dbReference type="GeneID" id="35407684"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14232"/>
    <dbReference type="HOGENOM" id="CLU_1204856_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT76137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="230" mass="26061" checksum="EBF57C1550DDB2C7" modified="2013-09-18" version="1">MEPNNLVPGYQQDDNLKIDNIESHHAGLSSSESVIAQVAQVITATMSPIMLVKLKTPNAPNRAILKLYDRRFGSSLRRSKKGKHLPCRVQDEAAFRSFVDRGDIGPFMDEMEKDRRTELLPNSAADWRLESGGQAKFEAALWWEARSHFETGIEAYRRLKDPQGVFIPCMYTSICFSPTSARASKDIDDYYSVNVILLQFIPGWSLWDLPESPSSPTLQREWTSIVQPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENA7</accession>
    <name>S0ENA7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436061.1">
        <property type="nucleotide sequence ID" value="XM_023568946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENA7"/>
    <dbReference type="STRING" id="1279085.S0ENA7"/>
    <dbReference type="GeneID" id="35402650"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09181"/>
    <dbReference type="HOGENOM" id="CLU_013866_5_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25997" checksum="79BD05E36C0E3107" modified="2013-09-18" version="1">MAALARRYRSQETLGLAFKEFSTALEQTNARLADPATATLNATLGAVFTLGLFESISTGQENINSWAAHTLGTIALLRLRGLQQFGDILSRRIHIHAAYNIRISCINRAVEVPQDLIQLEEDFYEAFNFPQAVRDHYSIMNRTCSINAEFKNGLTTELIYGAIEAKRDTDLFIQGFSPSATLANTVMLHCVTGVPPLAMMARWLFGMSMLRLVLNEIVLSGGPMHDGFLLSRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENJ9</accession>
    <name>S0ENJ9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436241.1">
        <property type="nucleotide sequence ID" value="XM_023568960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENJ9"/>
    <dbReference type="STRING" id="1279085.S0ENJ9"/>
    <dbReference type="GeneID" id="35403670"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10205"/>
    <dbReference type="HOGENOM" id="CLU_012494_13_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="41"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="268" mass="28888" checksum="155FC2413029F4A8" modified="2013-09-18" version="1">MRQNGTNGFNKPPEISEAENMTIKRRDGTDMELRIVKPTTGGLVYGTARGQDNYLQALANALGLTAVSVEYRLAPEHPFPASQHDATDAALYAISADGEDKLGGPLRLFAGKSSGAYLAVWTAISLRDDHGVDTKATLAGLVCSYGTYDISYTPSLLRHKRNIIVGRESMFRLMDAAFPPEQVVNRKDASVSPLYADLKNLPPALFLCGTEDAVVDDSVFIGARWSLAGNKAEVKLVPKGFHAFSLIPTGEIQKEGVSEVISFALSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPF7</accession>
    <name>S0EPF7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to hexose transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437116.1">
        <property type="nucleotide sequence ID" value="XM_023569977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPF7"/>
    <dbReference type="GeneID" id="35404578"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11114"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="34"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="517" mass="56790" checksum="C2F0025409F8DB0F" modified="2013-09-18" version="1">MATPEVTTTMALPASPVDTKRWWKSPNLRTLNFLMMIPLLSIFSQGFDGSMMNGLQSVSHWQTYFGTPTGAMLGFFNAAYPLGGILGTFLISPAADTFGRRWGLATGAALCCVGAAIQGAAMNIAMFIISRVIIGAGSVVVAGVGAPYITEIAHPAQRSTATALFLTFYSVGSIIAGWCTFGTFRIDSTASWRIPSALQGLPSIIQLLFVWFVPESPRWLVSKGRNDEALQMLAKYHGEGDSSDPVVQFEYNEILETLSAEASEHNNIVVFLKDLGSTPGNRRRMFIMIWAAICSQMSGNAFVSYYLSPILHSVGLNSDLQQTLINATNQMLSWFSAIYFATLPAKVGRRKLFLWSLAAIWVIDICITAGSAVFAKDNTNKAAAYTVVAFLYLFSPAYNLGFNGNLGLYIPEILPYRMRTKGLSFFYFVQFCFMMLSTFVVPIGLKDITWKFYIIFVGWVMVEFVGVYLVFPETKGPSLEEIAWIFDGPNSGVDMHAARAEGKNSTIVEHTDGKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ17</accession>
    <name>S0EQ17_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438166.1">
        <property type="nucleotide sequence ID" value="XM_023571101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ17"/>
    <dbReference type="STRING" id="1279085.S0EQ17"/>
    <dbReference type="GeneID" id="35407701"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14249"/>
    <dbReference type="HOGENOM" id="CLU_1138074_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT76120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="244" mass="26636" checksum="C6A08954B9122D71" modified="2013-09-18" version="1">MKKLQVTLKSSSEEEGSSYAKHIDEVHNWMMESLHLTGWQNDIVSLCQRMLDPDRARRPKAGHISSELSNLLVSDKPVHCTCTADSVLTEDDKLVEACKARSEDEVKHALKQGADPNTLKGIHYAAENGSVNIVGLLLEHGVDVDTPNPTGQTALQCAARNGSEDVVKFLLQKGADVNARDENDHTALHGAAGQDNSDIVKMLLDAGADPDAEDLDGNVAIEFAERRKLEEIIDILENHQIDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHS6</accession>
    <name>S0DHS6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anaphase promoting complex subunit 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423895.1">
        <property type="nucleotide sequence ID" value="XM_023575839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHS6"/>
    <dbReference type="STRING" id="1279085.S0DHS6"/>
    <dbReference type="GeneID" id="35395181"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01696"/>
    <dbReference type="HOGENOM" id="CLU_115512_0_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 11 RING-H2 finger" evidence="6">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT61814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="63" mass="7310" checksum="42B2FB9E09862E34" modified="2013-09-18" version="1">MKVTIKKWNTVATWRWDIPEDDVCGICQVHFDGTCPTCKYPGDDCSLCFEWNEQLKEPVTQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHW5</accession>
    <name>S0DHW5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sulfhydrylase FUB7</fullName>
            <ecNumber evidence="13">2.5.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Fusaric acid biosynthesis protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_01624</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="13"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423960.1">
        <property type="nucleotide sequence ID" value="XM_023576639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHW5"/>
    <dbReference type="STRING" id="1279085.S0DHW5"/>
    <dbReference type="GeneID" id="35395109"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01624"/>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT61879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="452" mass="48738" checksum="F816CE6C6D348E9F" modified="2013-09-18" version="1">MAEELSKNFETLQLHAGAEVDPTTKSRAVPIYATTSYVFDDSAHGARLFGLKEFGNIYSRIMNPTVDVFEKRIAALEGGVAALAASSGQAAQFLAISTLAQAGDNIVSTSNLYGGTYNQFKVFFPRLGIKTKFVDGDKPEDIAAAIDDKTKAVYVESIGNPKYNIPDLEAISKAAHEKGVPVDNTFGAGGYFIRPIDHGADIVVHSATKWIGGHGTTIGGVVVDSGKFDWGKNAARFPQFHEPSEGYHGLKFYETFGNITFIIRARVEILRDLGSTLNPFAAQQLLLGLETLSLRAERHAQNALALAQYLEKSPYVSWVSYPGLENHPYHETAKKYLKRGFGGVLSFGVKGGGAGSEVVDGFKLISNLANVGDAKTLAIHPWSTTHEQLSDDEKRSSGVTEDLIRISVGIEHIDDIIADFEQSFKAAADATTKGEKKDVPVGDKEAEAPLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI76</accession>
    <name>S0DI76_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribonuclease H</fullName>
            <shortName evidence="10">RNase H</shortName>
            <ecNumber evidence="4 10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_01653</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 10"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423936.1">
        <property type="nucleotide sequence ID" value="XM_023576317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI76"/>
    <dbReference type="STRING" id="1279085.S0DI76"/>
    <dbReference type="GeneID" id="35395138"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01653"/>
    <dbReference type="HOGENOM" id="CLU_030894_0_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000115">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="12">
        <location>
            <begin position="188"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT61855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="343" mass="37335" checksum="776C61B9BDD879DB" modified="2013-09-18" version="1">MVKKRNAPSGGFGAGSSSKMRKTANATKFYAVQKGREPGVYSNYDECQAQTTGFPGAKFKSFLTREDAQAYVAGHENPSADRDRPKFYAVAVGHVPGIYHTWDETQPQVTEVAGPKHKRFNTQADAEDFIRQNASPETCRRLGISLEKTQEYTGAAFEPVEASTKKVKAEPTRRPKAAPRAEPHHENNGNVLTIWTDGSSLANGQAGSRAGLGVYFGPNDERNLAERLPGELQTNQRAELMAILRALEIAPSAQDVEIVSDSQYSIKCVTQWGPGWEQNGWKNAAGGPIKNQDIVSSVLARIKARDAAGSKTSFQWVKGHASDFGNHRADDLANEGARKPPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIN0</accession>
    <name>S0DIN0_GIBF5</name>
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        <submittedName>
            <fullName evidence="3">Related to mitochondrial integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424166.1">
        <property type="nucleotide sequence ID" value="XM_023579183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIN0"/>
    <dbReference type="STRING" id="1279085.S0DIN0"/>
    <dbReference type="GeneID" id="35394881"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01396"/>
    <dbReference type="HOGENOM" id="CLU_028296_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="531" mass="59035" checksum="4ADCE93AFC9FA42D" modified="2013-09-18" version="1">MPLFSSPKDSIEDRPNGTNGSARINDPEEGEQAVPDEHTRLLPNRVNSTQPGLLAPDDPAVSPYNLWSIRALRYLTIAFTLITLVWWILLLVSTFVTPPGIGTRGSPWFAFGFATWTLANLIFTLLFFEVPSKSVRILAIFISGVILLDMVLILSVQKTRYEEGWVGAATVIWALLTSLWTLVVDRTVKWGKAEEEERLTGRAETRRTLFEWSEVMISTVAYAIMSVAVFLITLSIILRALDAGVSHPGKLYPVDNGKYRIHVYCHGNKTDSKGNNLPTVLFEAGERTVEYDFWSFADNAVKNGSISRYCFADRPGYGWSDNAPSPSSAGFVVDTLGEALAGAGESGPWILASAGIGSIYSRVFSARHGDHIKGLLLVDPLHEDLLGDVASPGRGFFLWLWGVISPLGLDRIPGAIFRGRTSRDRVYGRSAQQNGKFIFAKLQESLVAGSFTRRDALTSRQIQDKDTPLVVISSGKHIKDSHTWEKKQRDLTKLTKNLKNWDIVDGAPHEVWRTLEGRQKIEKRLKELVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ47</accession>
    <name>S0DJ47_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mucin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424401.1">
        <property type="nucleotide sequence ID" value="XM_023582050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJ47"/>
    <dbReference type="STRING" id="1279085.S0DJ47"/>
    <dbReference type="GeneID" id="35394625"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01140"/>
    <dbReference type="HOGENOM" id="CLU_008913_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="86810" checksum="A2F6DD6B0804BA02" modified="2013-09-18" version="1">MSQGDGIAALDSTLGWNEDQCPNRAEAVVAIDSNSMNARDSGSVNSQGPGRPDDIMSFFDNETLSSGSASLSQPLYPRPLHHYPHQTSHINKSRIHAQPSQVYTPIFETMHSLQRPKPPLQPQRQRRVPTRLDPNGSTDTSAIDQSQGLGDHSFLLPSRPMSIATTDVTPTKDEPTCSSSLYRAWAEEEQIELRIHSETNHDTDNLRHNSQYHDLLSEIDTECLFPDDSLTADHRPSSSRSHLLQWRRSPSAAASTASKHQRVSSDVQPPTTENRPSATITRQEFEALPPTIQRKYFSTIERSQLAQSPDLGNCQRPGSVGQDQLLSPWPSLPKPRGSYEHQERPITSDDSILRTDRPRITETDQKFYANLPEKIKRRHLTEEELQLAYKSQNTFTYAPEAVSNTVDIPPQEVKMPSPLPSPGLSEGTSPFPGMLSRQNDRAMTSSDIKRSDSFYDSFRWLDDEEGLDLRLYLDDYHINLREEIPVPNKSRRPSFRRHLSINKLPFGKPSVNGLGEGPASPTTLPPSASHSSSVGSSGHVRKKSRARALSLISANRQTPLASPSPLTPPLDPSAAHYRDPEARRKLRAYLASPQKFDEAIEFGFSSKDGPRPHTGFNKASAYDPDRLRSFLEDDRSSRYSDDASAAEPDSPKTPQLFDKTPHIRSLRSSNEHSSYSRGEKSIYDPAASREMTLRMTLTRPDLRQSEDQIYGWKQAGSRVSSSRGDHTPSPALYAREGNPKQSIERQLAALDQWEDPVGHDNRTVKRFWNRVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJC1</accession>
    <name>S0DJC1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_01063</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424471.1">
        <property type="nucleotide sequence ID" value="XM_023568108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJC1"/>
    <dbReference type="STRING" id="1279085.S0DJC1"/>
    <dbReference type="GeneID" id="35394548"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01063"/>
    <dbReference type="HOGENOM" id="CLU_024991_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042272">
        <property type="term" value="C:nuclear RNA export factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nuclear RNA export factor 1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
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    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="11">
        <location>
            <begin position="405"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="12">
        <location>
            <begin position="602"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT62390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="658" mass="71635" checksum="46A9770BFC4AFDA5" modified="2013-09-18" version="1">MAPRGRQNTSARETRNTRKPATTSRGGIQKRKAGRVDGDGDLDMDSAGRRAKKTTTADIKPTRSSTRTSTRGGPSKNAQNVLKHLSNGTAASLASRISSASSGKGPKTRSQDMTGLTVLRVGGLKESKAASNAGGGVNDLLGFMERKAGSFRTGSKRKVAIKKHHTVGDYVYIGASGEDASELIKLNTFTFAGAPLEVIEVDEVPDRGTAIESKTTLELRTKLQEILSSRYLGANKLLNLDALASDANLVTLGMFESRERALKTFRGLMAVCESLFKTDKEKQDAIESISLANNNIDDVGQVEVVATTFPRLKNLDMSGNQVASMQALQPWKGKFKYLETLFMTGNPIETTDPSYPSTLLEWFPRLQNINGTQLRTPEQIAEQEAALRPKPIPQNGPDFRDVGGIGENFLLEFFAAYDSDRPGLASRLYDEDSRFSISVDTRAAPDPNAAAPMSWASYIKLSRNLTKITMPNPRIQRLFRGAASIQDAWKTLPLTRHPDIKVEINKYIMDCHPLQGLVDPSGQSSGGVDGLIVAVHGEFEEQDPNTNATGKRSFSRTFVLGPGKPGKGVIRVVSDMLSLRTYSLLPNVFAAPVLIPTTAPADQHQAMITELCKQTGMTPQYSEMCLTQVNWEFDQALVIFNEKKSQLPAEAFATMVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK57</accession>
    <name>S0DK57_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423798.1">
        <property type="nucleotide sequence ID" value="XM_023574695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK57"/>
    <dbReference type="STRING" id="1279085.S0DK57"/>
    <dbReference type="GeneID" id="35395283"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01799"/>
    <dbReference type="HOGENOM" id="CLU_029201_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="415" mass="46968" checksum="25125A57905FAED5" modified="2013-09-18" version="1">MSAPEIDNAHDGVTIQHPPASKDTDPSTEAPTQSIETPLKFRIPEDCRTFSPFPRLPPEIRAQIWQATLETPGMHFLKIDTDWHPATGLGKWWLKEPIFLHASAEDHDDDVDSVALEVRKEARPTAKVYGTLKPLYPTPQADISYYTNLHQQLAKLSVTCNEAAAIAKSLTNRSTTFRLNTGRIVSLNSLSDVIYLEYVPPEVYEDSIRFNKVLNCSGLDQIRKVAVRYCHKWFLAQYLPNLEQFFFVDYLILRKSDLNAATDRYGFQRDLKGTCRFEGGNRSYFEADTQDWTISSRVLEVKSWLQENFVKYAKSSSLSAHKNPEQVEFSVLACEWNVEPPSEPKKALATPVKKGRNKRANSEEHTLSRTNRRGSTPTVSRPVADSLPLDVAINFPFVFDAAGSNNFESTFSMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKN3</accession>
    <name>S0DKN3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_00439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425037.1">
        <property type="nucleotide sequence ID" value="XM_023573292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKN3"/>
    <dbReference type="STRING" id="1279085.S0DKN3"/>
    <dbReference type="GeneID" id="35393924"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00439"/>
    <dbReference type="HOGENOM" id="CLU_011759_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="48"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="347"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT62956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="482" mass="55267" checksum="27B183A27FF11459" modified="2013-09-18" version="1">MDPGRKAMIAGRRSPTRRDVTSPRHDPSNRITKSTKPSGSKINPKYLTQDEQSRQFVADEDKFVLKQSKKKADIRIREGRAKPIDYLAFNLRYIDTDRDIFDDDDADIEIDVPAPGDVVASLDAEQIVELESDIASYHVLETNATNREYWRALQTICKDRKAKLDPHGHERRVVSSVSDDIDKILAPKTHDQLEALEKQIKAKLQSNEDIDTDYWEQLLRSLRVWKARAKLNQVYETIKETRLSQLKECDPTKVKASGQPTSAPRVTFGSQPVASASEEKASPAPVSSSRHVGTSAPPGTERFSQVDNVDFSQVTKALYDREVARGVDENEEIFTSEEAVTTTKPQWADKYRPRKPRYFNRVQMGYDWNKYNQTHYDHDNPPPKVVQGYKFNIFYPELIDKTKAPTFKIIREHGRRRGESFAAAGEEDTCLIRFMAGPPYEDIAFRIVDREWDYSAKKDRGFKSSFDKTPSPLHYMLMNPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKZ6</accession>
    <name>S0DKZ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425375.1">
        <property type="nucleotide sequence ID" value="XM_023573702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKZ6"/>
    <dbReference type="GeneID" id="35393558"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00073"/>
    <dbReference type="HOGENOM" id="CLU_077177_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484272" evidence="2">
        <location>
            <begin position="22"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="341" mass="35139" checksum="6FBF550DEEF128DA" modified="2013-09-18" version="1">MHLSILRLLAVGLAGIDDAVAGPCKLRSSVATSSFDLSSDTSATFASTTTEAVTSADTVTDITTEVTSAVIETETASTEATASGDTTTEATTFATSTATTEAASTTGADTTTEAAPTTTEETTTAAATTTAVPMFRLIPESSNYQGQPLLSNRVHFASLLFNSAQEYTDAYFTIGATTGRLLLDGTLPICGYFPGDGTSAFIVCDATNMPDEEQYLTCETPTPGSRLECTVPGVQCSMSSGCTATGTLWGTTYIGPSGGELGMKALIGPPSMPEDVPVPLLVTFDSDYINSAQGQLSLATLLSDSERNYGLQSFRDIGTQPGSPGHIDLVGIVCRAATAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKZ7</accession>
    <name>S0DKZ7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425136.1">
        <property type="nucleotide sequence ID" value="XM_023573408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKZ7"/>
    <dbReference type="STRING" id="1279085.S0DKZ7"/>
    <dbReference type="GeneID" id="35393820"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00335"/>
    <dbReference type="HOGENOM" id="CLU_370897_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT63055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="817" mass="91188" checksum="76C42DC2D34375FE" modified="2013-09-18" version="1">MADDNPAEASAAKPEAKPVNCHICNKSFPHKGSLRRHRQSKHPVKKEEADASGTGQDGEAASTFDCELCKQSFPRQSSLTQHQRSKHGPPKPEAPATSATQAQAAEPKPEASAANEASTSAKQEDTNQGDKGQESKTTCSICNRSFSHRGALYQHKRTKHRTIKTDVETPTKEEYKAPDDEEKTIKCDVCDKLFTSRNSLRRHLKSKHASDKKGKGPAKSSEQGGKAAGSSKPVHATLKERHIAGSQRFKCPCCNENFPSEDTLMKHQAEQRLEAMRKVMENMALAASGMRVSNGQDGSDEESEEQEPAEETATEEKKASNMHQCTLCDKSFRFKSALVQHGLIKHAVADDTVAESSGQGANATAAGKKAENVDGDEDEDKPYCQTCQKTFRHAKGLADHKLNKHGIVETEPTNSKQGVPENPTFRCRPCNKTFRLASALRQHQRDSHPEMHGPRYSEDDIMRQLLRMAVPPFGDDGDDDDYEDEDYEDNEDEDDPFSYPGRRGHPFDFPAGIQPGDIYDSDDPDFGYPGFSDDDGDEDDSDIDMDNERGPPTLCTHCNGYFPQMLLVAHQWHVHGISHPAVVDVQAKIAKDDSYGPKRTVCKGYPDPQNFPFFFEAKYFLRDCKYKNCGQDFETGTERINHEVEAHNRCITCEMYFQTPSALEKHQSKSKVVDTVVRDFDHWLEFAVPAQVHHEKQKEKAARNSNPNKNIDCITCDRKFEKASTMMKHVERGRCIPDVNEIDIFAVGQTLANRGAPCVRSGGFFCPICDKSYMVLSELIQHAEGDECNLNVLSGPLRELISLVMMDFMSMMMGHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLK4</accession>
    <name>S0DLK4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_00045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425402.1">
        <property type="nucleotide sequence ID" value="XM_023573733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLK4"/>
    <dbReference type="GeneID" id="35393530"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00045"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="510" mass="54904" checksum="58E7B7F509173B38" modified="2013-09-18" version="1">MDVKPTTNLDDYQLAQLGHSQSFKRNFSRWTMLGLAFAILNSWTALAASLSLALPSGGPVAVIWGLVTAGICNLSLAASLAEFLSAQPTSGGQYHWVATIAPKSLKIPLSWITGWINLSGWACLVATNCSLSSTLIINIISLQNPSYEFQRWHQFLIYLGIAFIAFATNAFLHSLLPRINGLALVWSIAGFFIISITVLACAAPEYATADYVFATFINTTGWPDGIAWLLGLLQGGLGLTGFDAVAHMIEEIPNAASEGPKIMLYCQYIGISTGFLFLIVVLFVSGGIKNADTIIGSTAGPLLEIFYLATNSKVGAICLLMFPLLCLVFAAIAVMTTSSRMMFAFARDGGLPASRIWWKVHPKLGVPMNALYLNVVIVVIFGCIYLGSTVAFNAIVASSVVALGLSYGIPIALHLASGRTQLPEGAFKLPNWLGWTTNIIGLVYTIVTTVLFLFPPALPVSGTTMNYCVVAFGVIVVISAIQWVVDGRKNFEGPRITIGEHEMTERDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLM2</accession>
    <name>S0DLM2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425590.1">
        <property type="nucleotide sequence ID" value="XM_023573615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLM2"/>
    <dbReference type="STRING" id="1279085.S0DLM2"/>
    <dbReference type="GeneID" id="35393634"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00149"/>
    <dbReference type="HOGENOM" id="CLU_037227_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="54637" checksum="1AF30A5C53F3C95B" modified="2013-09-18" version="1">MWILRWTISKQREAYGEMAHFQFVTVQGPPDKTSDKAAKRLARSHAVKQALQKKRQMQQQSMQHFAVRTIEDEREQTRSICRRHCTKRTIPSPVSLSASLLDPFQSLAIDSKRLQILLNDFNARQAPEPVFSVEDDFQNFKSVFRSGLVDPALLNAFMLSLAFTANGGVINKECLVYRGQAIQHIRERISMPDKVVSESTIGAILLLVGVEARLGTTSQVQLHMGAIQYLLNACEPIVVNLTQGIKRAIFWQDLNSSIMVGSKRIVDHTTFTDLRWERDSIAPDFFELPLGFQIRSHLFSQEFLDIVRDIHALQCIRNIYQRTGRPVSTSHSIHTISSSGSAEHLPDIQSLPSRSVHVLSNAVLQSLVRFSNSCESPCNLWKHSLTCKSNITAQLLKEIEKVRHEPVWDEHADLLLWLICIGGVFAPVGPVRSGYTALLRSTWFERPDLYDSWSDISDILNQFIWSDLAFGSAVRKFLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM96</accession>
    <name>S0DM96_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HRQ family protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425636.1">
        <property type="nucleotide sequence ID" value="XM_023571306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM96"/>
    <dbReference type="STRING" id="1279085.S0DM96"/>
    <dbReference type="GeneID" id="35398785"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05304"/>
    <dbReference type="HOGENOM" id="CLU_025462_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42229" checksum="22E0E05CBA0D9E9E" modified="2013-09-18" version="1">MTSLYHLNGSLQPFARLLFLPAAVLMSIWVVTTTAKRWMRHRRQHLQAAKAEIVPPEKVLAIEPLHDFDWKTAPRRQFRPFKPTYHITMAIRADTPSELITIDEDYLDRVTHRRNIIATHGSTVHGCTPEGDAAVRELYTYLLSEQLPKRFPTIFKLSKDNSMCENLATGMSFPTLPEGNMDAALRVLGETVEEDIFLLQETPEGHRSVAFMCCFPSGFDPSSKLGKTLVEIHAPVPSYEKIGSSMEKFFTKLEVGKSVKRTNWSVQTHTELFNCQGNHITGDDKYENDEDVDIEKTFLRIELQTLTRLPKTRAILFSFKTYLYPVRQVKDEGLGPAFADAIEGLAKGNAPGMWTYKSAVRWGSSVITYLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN46</accession>
    <name>S0DN46_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424893.1">
        <property type="nucleotide sequence ID" value="XM_023573114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN46"/>
    <dbReference type="GeneID" id="35394083"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00598"/>
    <dbReference type="HOGENOM" id="CLU_631758_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
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            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
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            <end position="431"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
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            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="431" mass="47240" checksum="1333844867213D26" modified="2013-09-18" version="1">MTTTMLYATGISMEEPSHRFSPTTVAPGKPRHRPKALQIQPLDPSELSAKLNDISVEHEGQPRRPVHTEDSLRPPLSATSMGALSPRTIQTTHALPSIPTPVSSRVFRKEKTDDKLSSPLSAKPPRRGSFFDAFHFRGSNYSDETQKQTEKDVQKPARYRHVPQVAAQQFARTTTVEPLTQKASSKGMRPAPGPHSMNNGTISLQEYNSQYRRAQSLCSGRPTSASNVARTGGTELDKVSTQRKRQTARNSMLWNVNGPELSRRMSTGNMQPLPQPRRDSIGTGVGGFQGNAASSVRRGSASSSGFSDASPFVRESGPATPFKQEFGINTSPNRRGSETSAATSGSRRGSFVNIPNPQHAAEIHRVDWSQSDQPVKVRRDSKWGGLKHRKTSLSQQKPNAEDQGSNFTKTSSQSSISPKSPKSGFLKRFMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNE6</accession>
    <name>S0DNE6_GIBF5</name>
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        <submittedName>
            <fullName evidence="7">Related to low affininty zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_00468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCT62927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023573260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNE6"/>
    <dbReference type="STRING" id="1279085.S0DNE6"/>
    <dbReference type="GeneID" id="35393953"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00468"/>
    <dbReference type="HOGENOM" id="CLU_027089_1_2_1"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF60">
        <property type="entry name" value="FAMILY ZINC TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="146"/>
        </location>
    </feature>
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            <end position="375"/>
        </location>
    </feature>
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        <location>
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            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
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        <location>
            <begin position="203"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="449" mass="48524" checksum="98221D633281FFA4" modified="2013-09-18" version="1">MSAHLEVPRGESWASIPTDLILAELKRRKDDGDKPECGSRTKGSYDTSAHVFALILILTLSTLACAFPLFSRRTMRGRGQKTVIFYCQHIGTGVLLATAFVHLLPTAFESMTDPCLPDFFSKGYTPFPGFVAMISAIIVVGIESYLTARGAGHSHSHNHGYFDSDDEHESELPMMDAAGLSERRHGPRPPDIHLENMESQGLVAGVSPLPGSSPLVGQEGKKLNDDFNDDDSDLDLDMEELEPAGSSSTRHRHGPYASLKPEGAGAEEEPMTPMTPMSPGPHNPEEQQRKLLQCLLLEAGILFHSVFIGMAISVATGPAFVVFLVAISFHQTFEGLALGSRIAAIQFPRKSLRPWLMVLAYGTTTPIGQAIGLIVHRMYDPKSAGGLLVVGFMNAVSSGLLLYAGLVQLLAEDFLTEKSYKILKGKRRLQAYMAVCAGALLMAAVGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP31</accession>
    <name>S0DP31_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to SET3 complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023572258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP31"/>
    <dbReference type="STRING" id="1279085.S0DP31"/>
    <dbReference type="GeneID" id="35397935"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04454"/>
    <dbReference type="HOGENOM" id="CLU_009510_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="280"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
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        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="908" mass="99725" checksum="580C8FD7EE8E1068" modified="2013-09-18" version="1">MTDRPAPLSTHSATPSQIAPLSLSGATPNDEVAQLIEGAEEEPYTIKCICTFSVDDGNTIYCESCDSWQHIDCFYPDNREEAVREDFAHSCAECKPRPLDRQKAYDRTLRLINGATDEPADKRTKRPPSKSHKKRSRPAELPINGHASPQENGKHGHSGDHHPPPKKAKHRSSHSVSSQAPKRSPSYGNGRTNHAHPPSPATTPPDLPDDFQIHHYSEKFYDLYNARDVPESRNNAFASLAIPTALSRWLREPNTMRSEVGRRHSEVFQKAPSNLEANKPKLEVSDATRTLDDGKALRWRFLKSSTPIEKDVPLVELNGEIGFQKDYCAEPVNLWADLSSPLPFVFFHPVLPLYIDTRQEGSLARYVRRSCKPNAQLDTYLSEENEYHFWIVSDRYISANEQITLPWDFRLEKSVDARWLHLLGLSDDDSTNNTETPVDGTEYMAISNWIDRILSEYGGCACDLDNNCAFARFHRQYLFGKPQGRAPAKKKSRKPKTQAISPTNTGQTVTSRATSEGHVDDAGDNDNRSQSGSMRSKPPSRDLTPLRQGSFDQLGILTEPTDRDKRKVAMVEDSFRRMEQQQPSRKKKRVSDGTGSTSSKSKHRNGSVASHGNYVDAGTCRSHSGSPASSSPHIQQRPSISNQDSTATPSRQLSASPRGVYCDAAVQTDPVEGAWFSGPHQSPRPKKRIISLSKRLLNSRHRVRAEGEDLRRRSSVSQLSNGTIMEVDSPLEHEVVIKRSDSELPPLFSALGDTHMADTSSPTTTPVLGSASSDTSIKTKTPDLRVQLPPVPAFDSAGLGIHNATTPKSGGVGHSPLAGPLPSPFAPPAVNGIGTHPSPVKKKLSLSDYTKSRMNKAAGRTAGGHAVLKPSISSPEDTKVDIMVDPPSIEKPAETLIMAPVAAANASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPA9</accession>
    <name>S0DPA9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426351.1">
        <property type="nucleotide sequence ID" value="XM_023572178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPA9"/>
    <dbReference type="STRING" id="1279085.S0DPA9"/>
    <dbReference type="GeneID" id="35398006"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04525"/>
    <dbReference type="HOGENOM" id="CLU_074173_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495017" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="22408" checksum="8FEE0A14E16EE435" modified="2013-09-18" version="1">MARSLALLAGALATVAAQTTTVEFLLPMFDPQPLEGSVVAVKGGATTLAIHCPDAKATNCGLASTSTIVGGPSTIEYSYTMHPDVDGFDGGEIKQNMGCVLDPKKDVATCSVHQVAVLSGITDVTSMTDSVSGYKSLLMPITVTAGVNKLNGNDDASATEAAGSEATSADKPKDTGAKATDTADATTASSDAAATPVSSDNAAGPMITQNAILAAAAVVGGAAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPL7</accession>
    <name>S0DPL7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_04396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426467.1">
        <property type="nucleotide sequence ID" value="XM_023572324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPL7"/>
    <dbReference type="GeneID" id="35397877"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04396"/>
    <dbReference type="HOGENOM" id="CLU_144931_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT64386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="117" mass="13243" checksum="ACD8D9802F3AE884" modified="2013-09-18" version="1">MSEMEGVVATQAVVAMDIIEPEPHESRDENKPAFDIKKPKPTLQIRDNLLYWKCNQTLHDGSVCGSYNELDFKQCKDCKSRRGIGDDGTDAYGTKIAKIVFVNNKNGEELWQYASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQB8</accession>
    <name>S0DQB8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425673.1">
        <property type="nucleotide sequence ID" value="XM_023571354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQB8"/>
    <dbReference type="STRING" id="1279085.S0DQB8"/>
    <dbReference type="GeneID" id="35398743"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05262"/>
    <dbReference type="HOGENOM" id="CLU_064982_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495046" evidence="2">
        <location>
            <begin position="20"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="357" mass="36650" checksum="199BB81C314A70B2" modified="2013-09-18" version="1">MMRLTTISCGLSFLSPIYARVISDPCATTTTLPVITVTKGPNGYYNQYTRTYQEFYPQGLTSKVYTITQLCSSVNCQPLPIETAPPPGFTSAVVKCDKCGGSGTKVATLTFPNESAQAYSSSGYVVVPIAQPTQIPLGQSEQSHSSSVSENSSSSSDAGNALNNHGTSLSTNNSPDSGDSAAQDSGSGSQEIQDISNIGSMQPQSNNGDSSGDGESSDETDSVTPGSRPLSETPTAGYQFSPSNSSPAGSDGQSSSSMDDTESSDTAATGDENPYPISNQKVGNPYAGDTSGASSNGSGSLGNNSPSTGRPATKVFGDDSWSPDSPITINSAGHIKTNVVKCVLANTAGMFVLRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQD7</accession>
    <name>S0DQD7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426741.1">
        <property type="nucleotide sequence ID" value="XM_023572658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQD7"/>
    <dbReference type="STRING" id="1279085.S0DQD7"/>
    <dbReference type="GeneID" id="35397578"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04097"/>
    <dbReference type="HOGENOM" id="CLU_036645_0_1_1"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="345" mass="36687" checksum="F58C15716A67A975" modified="2013-09-18" version="1">MSSLINPTMRSCASLLSRVSVPSTRPASRTLGRAVRPLIIGGAAQTRYSSHSPMGAPPAVQRKKVTVGTLRSMHRKGDPITVMTAHDFPSGHVADHAGMDIILVGDSLAMVALGMEDTSEIILEEMLLHCRSVARATKSAFTVGDLPMGTYEISPDQALATAIRFIKEGRVQGVKLEGGKEMAPTIKKITTAGIPVLGHIGLTPQRQNALGGFRVQGKTSSGAMSILEDALALQEAGCFAMVIEAVPAEVAALITKKLSIPTIGIGAGNGTSGQVLVQVDMIGNFPPGRFLPKFVKKYGDVWGESLRAIEAYRDEVKSRQYPAPEHTYPISAEELESFTKAVKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR39</accession>
    <name>S0DR39_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426992.1">
        <property type="nucleotide sequence ID" value="XM_023572957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR39"/>
    <dbReference type="STRING" id="1279085.S0DR39"/>
    <dbReference type="GeneID" id="35397308"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03827"/>
    <dbReference type="HOGENOM" id="CLU_746054_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="374" mass="41168" checksum="9C1CDCF27AC4F911" modified="2013-09-18" version="1">MEAISAIDGLLACLVCLDKSNSQVMSLFIHDLETQIGHYWERLRQIVSTQATQSLTVLFNSFNSSTTFLEVAIFTFRNILVGAKPDSLNAIFSLCSLSYIASCCLRRVRLQTDDIFRDIDVWRNAIRDPQERQTFSDLAGIVWQQVSPVSIDNTLNSQMPSSLRPGASTQPTIATQSSALGFDFLQDEWLFGGLSSAVWEPDVMPDSSVVDVENLHRTSSTLEDLQGSAIVSNLICFLTECGDLLHVFSGRGVTTKDLYSCIAFTQAGSEAKNVVNACVKRLKSGFSSQNTSTGGILSIVERFVELGYLQTPEELRKYMLCVGRTVILEDEAFATFCQSVCELTVTVSRPPTPPRATPPRGGGRRRGPRLIPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRJ8</accession>
    <name>S0DRJ8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426103.1">
        <property type="nucleotide sequence ID" value="XM_023571869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRJ8"/>
    <dbReference type="GeneID" id="35398282"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04801"/>
    <dbReference type="HOGENOM" id="CLU_093250_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="26688" checksum="9D4EF1D1FC7CD120" modified="2013-09-18" version="1">MGASSLSLNPAQQGGEAPVTTIVPFNNQKVLPACAAACGPLYDANGACVPPQVAADAGPTAYTQCFCLDQRVAAFSTATTGVCDDACTADPKGLSSIAGWFRSMCSVSTAQNGGTTKKTGTGGSTTLTGDDASSTSGSKLSNNGGGGDWLSNHWQWVIMIVVLVVGIAAIWIGACIWRRRYLRKKDRQTHLGQKHSGSASRPSWGPGMEASESGGLPYDDESNRNSHGLMLPGAAAGAPVEEKPKEKKRWIVRDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSB8</accession>
    <name>S0DSB8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425539.1">
        <property type="nucleotide sequence ID" value="XM_023573250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSB8"/>
    <dbReference type="GeneID" id="35393962"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00477"/>
    <dbReference type="HOGENOM" id="CLU_027514_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="518" mass="59197" checksum="4D3D30909131D7A3" modified="2013-09-18" version="1">MATDDIISLKSRQKRRLYEPIVLYKALTEITHEQGALRPAEAPERPRTEEERYHHFLHKLASICDSTKGGKTVTSIAILDEEEKYKYIFACNQISDGDLGDTQDLLTTVIESLYGFHSFPLDKKKTVESELRKKIVSFNSSRINCYLNALKAKNIVDCLEYCQLQTDTANTSVEEGLRSLERAIEDTTFKNMGDNEYFETYNTIQQALEAFLTREVKSYVDKRATNGRFSEGRSFVCWSELRHSLSRLQSYKKTIQDLIAAEREWPDIFQEFEVVSVESSQTEPNPLSKKSEKASNIIGRMCSNEASRQRYCDLAQNLQRMFDLDDRIQTQCTKSTFKPIVHCEILVLEWIMGLNRELAQKHYPGVTFFNGWSYIGSSKPACQLCRYYFDAAGQHNGIRTRAGHGNLYINWRFPDLHESCGTFGQTRRQSIFNSMIEKIRQDAFGILVMRNSEGKRHDSSTHPLMSVRYTDVQTELSVGDLPDVDELGEGFATGLSLDSPSNSLEESDFDNEDGGTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSS4</accession>
    <name>S0DSS4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426538.1">
        <property type="nucleotide sequence ID" value="XM_023572410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSS4"/>
    <dbReference type="GeneID" id="35397800"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04319"/>
    <dbReference type="HOGENOM" id="CLU_860659_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="323" mass="36279" checksum="6E9602DD76AA9052" modified="2013-09-18" version="1">MDYTEFCPKTGRGHNELRTELKALGEASFCPFCRQPLIEAVEVVDLTASSPPGPSSMTIQTERTRPIPITYTNAINMATESQQHSIAVTSRKSTITIELRATFYIASGYLEEVIPGISMPKYDKGVKSKNIKSKITAPLGSTFSSHDEMVHFIVSSCHKEFSSTKWKLISGYITGTHSNGPIMYGDAVYKTLRLKDFFEAASITLSVRAEAPVSLMLLYFNVRDNSEDSDTPRPNKRAIEQAETEIPASKRTTKIKREIKNKKEPVRDKRKENDIKAEIKVEVKAKKIKGEEERQHEDLDAFEAFLQSTTSDEDQGGKEDKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUB3</accession>
    <name>S0DUB3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428260.1">
        <property type="nucleotide sequence ID" value="XM_023575002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUB3"/>
    <dbReference type="STRING" id="1279085.S0DUB3"/>
    <dbReference type="GeneID" id="35396666"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03184"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="497"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="588" mass="65018" checksum="9F488121B90286A4" modified="2013-09-18" version="1">MSDPPSRIRSILNHLRPHPAAPVNFHTLSPTTFLERAASIEPDAEAIFHITVNGAVLRRSYAEFADRARGLAYYFLKHGYRRVGILAPNTPAFLESIYGIVAAGAVIVPTNYRLKQDDIAYIFDFAEVDCIIVDNEFVGLLDAYKEKHQSVPLIVDMVDLPPRAHVHSCLEVVANLARQDTDATEGQLSGPFDEAVLEGLKHDIDQGSHGWAGLHAQARSEDDMLAIPFTSGTTSRPKGVVYTHRGAYLAALANIIESGLNIGRCKYLWTLPMFHAIGWTFPWSVVAVRGTNVCLRKIDYPLIWKLLKEEGITHFNAAPTVNTLLVAAKEAERLPQEVKVTVAASPPTGYLFEQMTKLNLMPVHVYGMTETYGPITKCYILPEWDNLPPQEKFAKMSRQGHGFITSQPIRVIKPDQPQGVLIDVARDGKEVGEIVFTGNICAKGYYKDPEATRQLFAGGVLHSGDLAVWHPDGSAQIQDRAKDIIISGGENISSVALESMLAQHPDILEAGAVAVPDSHWGERPKVYITVKDGKSVKGEEVISWAKHQSHISKFMVPREVEVVDELPKTSTGKIKKNVLREWAKHGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV64</accession>
    <name>S0DV64_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to anthranilate synthase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428535.1">
        <property type="nucleotide sequence ID" value="XM_023575338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV64"/>
    <dbReference type="STRING" id="1279085.S0DV64"/>
    <dbReference type="GeneID" id="35396968"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03486"/>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005950">
        <property type="term" value="C:anthranilate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="1">
        <location>
            <begin position="242"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="1">
        <location>
            <begin position="336"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="1">
        <location>
            <begin position="488"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="576" mass="64110" checksum="394C5405E8ABB43F" modified="2013-09-18" version="1">MAHTNLLHQLDIRPTADEARAAFNQEWTPTTQPTLLPVCASAPADLLTPSAIYLKLSSGATAEYSFLLESATGSTETVGRYSFIGANPRKVLATGDGYEHNGDPLKTLAAELSNDRVLDIPSLALPKLSGGAVGYVSYDCIKYFEPKTERPLKDNLQIPEALFMLFDTIVALDHFRSTLTIVTHMKLPKSPSDDLQPAYDEARETLRKTLDIIYQPETPLPAQTLSEQSESEQQYSSNVGRKGYETFVKELKKYIVKGDIIQAVPSQRFRRSTKLHPFNIYRTLRTLNPSPYVFFLSCADFHIVGASPECLMKTDGYAPLPSDSRFGYSAAEARSRPRIVNHAIAGTIHRGKNAAEDDRLAAELLASKKDRAEHVMLVDLARNDVNRVCHPTTVKVDRLMRIDRFSHVQHITSEVSGVLRPECTRWDALRSIFPAGTVSGAPKIRAMELIYDLEQEKRGIYAGAAGWFGYDIVRVDEGSKPEDKVFVDEGPMDTCIAIRTMLVKDGVAYMQAGGGIVYDSDPTDEWMETMNKLSANLRCVELSERYFGDGVSTKTVEEIIAIERRKGEEEVKEAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVM9</accession>
    <name>S0DVM9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426614.1">
        <property type="nucleotide sequence ID" value="XM_023572503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVM9"/>
    <dbReference type="STRING" id="1279085.S0DVM9"/>
    <dbReference type="GeneID" id="35397717"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04236"/>
    <dbReference type="HOGENOM" id="CLU_022339_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="639" mass="71449" checksum="C31488B0C07B27D6" modified="2013-09-18" version="1">MEKLESQSDTDTDIDIDMGDSISEPMDTADDGHTGPCAPCPTSIPASALLPIRDSYTSRRNDLSDDRDDDADSDTEFASIMATSMLNGILNTASNPVSPGSSSPSHDQAKTSDFVPPTRPSSTPFPHPDRRHSKPCCSSGSPHGADHDTPTDSTAFPDNEPVVLPRPITDFNQLPIEVHEAILDHLFGYRVSATSRSSMAVSSITKSWGTALRHSRRRELTELALVSDVWRILVQQRLYRHIKLKATVDCLEDAMVHLALHEQLQSYVKHIEIWFPVFQPTYGPVALSNTLTLPTVTMEGLTNATYTLPGNNCTLEQVFQFVGQTLPQARVLTLEGGERRKAPRVLHFPEQKIDPAIYKPLPVLESVQTLVTRGQWNLMRDDQDFATVLNALPGLYEWQGSYSKPKSKSYITMAEFLPKLPRHITNLSLCLESDYRREGVMPPFYSKVVQKTHICARMAEALPSLEHFAYTGRVCHHFFDVAMRSTDSRTSRLKTLDLTVKNCCRYNTSFHEAGSGIQDMGFIDAFEKLVLSAIRSLEKLKEVVYLRIRFVDLDSVLPPLNPFFIMHKGACSGVWSERILAEMGRVRPDVHFPELSESFGNIVYNKDGRMVITPDPPRTKIASLKLSNYRSLATGITIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVQ0</accession>
    <name>S0DVQ0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428647.1">
        <property type="nucleotide sequence ID" value="XM_023575470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVQ0"/>
    <dbReference type="STRING" id="1279085.S0DVQ0"/>
    <dbReference type="GeneID" id="35397086"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03604"/>
    <dbReference type="HOGENOM" id="CLU_005047_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="931"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1239" mass="139178" checksum="A778F6FD5F5BF6BD" modified="2013-09-18" version="1">MRTKHSTAWPQSLNGEILWVCRDHVEDGKSIPYSFSSKRDLDQHMLLIHFSKKRLSDDEFTKYLEQQTPLIGTTSRPSCPLCLFVVGAKEYSSSGYGEGMLDLSTMVQENNKLQKSVDSRVSYVDDVKPASDAGCGDNLGDDPSTHFALELHIAAHLQYLLVMSLRLVATLDYDTGDEFSTGLHGSSDAATRSISSRKDGPERDAWPDEKSALLYISDSERLQLEQKRLSEEAAESVHSSYEDFQWNGLNLLVDNPTGEDLILRHFSSRQNDVSQLELYRKSVRSLRQELVESHGEHVEHAYQWREVGVLQGRIFDQSGDSDDLDQAVEALKTAAESIPDEHPVKGQNLADLSTRLIDQCKIESHRVDLDYIMEITKKVVPTNPHQQHDHYLNLIYIHRYRYSKTGTEQDLNTAVKIALEAQFWDPERKQAEYHRQLGELLALDYWRTGVENTIFKAISELRLALDCATEEDIKYSEYLAALSAGLDKKFAMSGSQEDLKEALQLTRRSIALGDEHGTDYLRRLDSLGVMLGEVYEKTGNTIALEESIQVARNVVASTSEHDTDAAERMTHLAARLEDEFQRAGDLEPLDEAIDLSATAKDLTPIEHPSYHVYCHSLVARTFELFNRTGSMQDVRDAFEYSSEAVKLLPDTDVNMAMYLCLLADLTLEMSSDLGNNEGDGYYYEGEEALRLYEQALSHGYPALQSRLQAGQKLFEADAKFPERNGAFEATKMTIGCLTHLPFADLEHLDKQRVLQTTRWIASEGVAAVLRHAPFEILSLLEDSRCLDANSRAYCLDDFERLRQAHPSKLDEFLALRKDLRKPMFVPPTGFIGNSPWRAQSRRRYQASIDCQRILTEIRNEPGFSNWLGPEDESRMLEAGAQGPVVVLTTGHSGSAAIIIRQDTIEVLRLPDLDYDEVVEKSDSSGRFTVATLLWLWETIAKPVLVYLGLSATPTDSRPRLWLIPTGRLSYYPIHAAGDYKSRSTDPVSVLDYVVCSYIPSIKALNMARKRRIAIPENPKALLVSGKGSSAVAGHQSISKEISAIKNICQSRGFEVFQPNHKEDILQALTSCTLFHFAGLFAGSREDPFESQLLLSSGVTTVKDIVDTTPRLHPPYLAYLSSCSTAKTYQDVFTDECLHAAGALHMAGFRHTIGTLGQVHDDLCSEISDFFYGAWAEKEFSDDTVALCLHESTRKCRDWWIASRDGPITAEGTNHRGITPIEDEDDYTVVDWASFVHFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWE6</accession>
    <name>S0DWE6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426889.1">
        <property type="nucleotide sequence ID" value="XM_023572834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWE6"/>
    <dbReference type="STRING" id="1279085.S0DWE6"/>
    <dbReference type="GeneID" id="35397419"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03938"/>
    <dbReference type="HOGENOM" id="CLU_001305_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="828"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1147" mass="128658" checksum="F773851649590DF3" modified="2013-09-18" version="1">MEQTLTSPQGTEVPGTSVAESSYTTPEDRLERLVRSYRDRNDPDQLEQLIQTAREVLEATAKPDAKLLHTLAWALYIRYKDVIDDFGDLEEAAKLERKAIETSPSDSMDHQRFSYWLAQQLGDSFYHTGNVDDLDEAIGLIQGSLKSLPNKSPMRAAHLANLGILLKEKYSVLGVKDDFESACQNLETAIASSSEDQNITATWLEKLADLYDVKHGNFGKLEDLEIVCRLRKDSLSATTDDYELDRLARQVQLARTLYELFEETRDLRELRESIALTREVVSATSEDDPEWLDRIRKLNVTIYIMYHETGDMKDLEEAIDIVKRYLEKATKEHHHWSEQLSNYSNYLDSLHSRTGDLAHLDEAIELGRTGLKDIPKNASNLQIVLGNLSIALSRRSMIRGSMVDLEEAVSYARTSLEVAPIDSPSRYIQLHNLGSILLKRFSRNQENESDLNQGISLLRQALTSISSTNPEIESILSRLASALDTRHDKFESSDDLEEGIEVARKAIAAMVNPYTERPTAISTLSALLKKRFRAGGSLNDITEATSITQNTLESMPEDSPFRTDLWTTLGDLFAAKFSKTWVSGDLDEAVRSYRCAVEHPTGNTLRRIIAATSVMPLCLSLQEAYDIGRTAIDLVPGIAAARSLETSDRQHLLSFSRGLAASVTGAAIRLDRDPSEALAILEQGRGILGSSLDDIRTDVKELQQVFPQLAGRFIRIREELESPNGSHFSDELGEDRGLRRRNAAESFDDLLDEIRNMPGFEDFLCPLTTDQIRAAAAYGPIVVINSSWMGCEGIVIERERITSMVFKDLDDGELMERAAGFDLGTPDMLEWLWDTITSRVLELLGFKKAPSDQQEWPHIWWIPTGPLSRFPLHASGRHQERSGNTVMDRVISSYSPSLKALVHGRRQREVVTGPSHALLIDVEHTDGHSRLPQARAEIKVVSEICESMAIRPVLGGQSKQDMLSCLRNCKIFHFAGHGYTNGEDPSKSHLCLSDSSDPLTVGDILKLNLNERSPFLAYLSACSTGRVQDDKFIDESIHLISAFQLAGFRHVIGTLWEVRDKHCVDVARVTYEAIREGGMTDDSVCRGLHRATRILRDSWLESLDKKRERLGQGDEKGLRDIVPCDNDEGVRGEQFPAYWVPYVHFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWI4</accession>
    <name>S0DWI4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428942.1">
        <property type="nucleotide sequence ID" value="XM_023575666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWI4"/>
    <dbReference type="STRING" id="1279085.S0DWI4"/>
    <dbReference type="GeneID" id="35406485"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13029"/>
    <dbReference type="HOGENOM" id="CLU_005931_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="919" mass="104960" checksum="68FE1CDD761352A0" modified="2013-09-18" version="1">MSNPRKRPRDERNEEFIRYVRQESQPGLDGNDIATRFVSPAVTARWWKKSGQRRLSRAIDRNIHALPTTIENGYLNIFSILVYISRTYLINNFTSNGYQDQQLPLLNARCFGDDPALVDDMNEFCEHQWMFCPLIFSRHSPMDKRHIDPRQILPIKKTVTITTDSNHSKSNIRVVTLYPECFDREWSPTGTVVFKEYRTGERETLRDAWIKEYNAFAAIESCDYIVEYLGSFEQNNRCFMILEHASEGSLLELFKRNERPVTEEERRYFLYGLMGLTKAIDKIQNLEGGPRNQRTGFAHRDIKPANILVFPGQDGRYSYGFRMKLADFDTATPNLPIDEDESSFQDNDGNRTYCSPEATRLYRDQEKGFMQVPVASDVWSLGCVISEAIVWVAGGTAALDEAASDRRREILTHWPLLADGSFGECFHNSSTALTCVVKSHSAALDALHGPIFLSRNVCSLVEHWMLVPYRERQSPILIWRTFERNYREIFHPAPPLDHHSTPLLPQPSFHNTPILTQSPMNMAESLFQPDRSPHQRTSSHSGSSRQIGMPLDRPNMQQRDHLGINTRMPSNNGTPFDRHTSAQWSHNNFRAISELEDKSSPALAVSTKDFNLGNTLGSPTHPGISFPAQDNHYHSIPDANSPAKTSADITRLTPQKQNEVGMYGDLTIDHVVSHRKNNGKRESLQGYEKFRNRMGNRRFVFIVDDSETMRDREREVLKVLDVLVWLVRKIDHSGPEIRFTSKPDKRIPIERRPRFLLKMDKFINPVREWLGGNDAETLCNMKHSFNQIFADASMVDPKRPTSVVILTDGIWEHGGSLEEKGVEACITKIIKRMEDKGIGDTAFAFQFVSFGNDPVGLRRLRYLDDDALYGGDEDHRTDIVDHKSSESNVWAILTGSVSPGNDKISASPSIERPSYSQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXZ5</accession>
    <name>S0DXZ5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_13640</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429510.1">
        <property type="nucleotide sequence ID" value="XM_023576348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXZ5"/>
    <dbReference type="STRING" id="1279085.S0DXZ5"/>
    <dbReference type="GeneID" id="35407094"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13640"/>
    <dbReference type="HOGENOM" id="CLU_016265_3_1_1"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="121"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT67429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="574" mass="65104" checksum="0DDB0CC9EA3556B2" modified="2013-09-18" version="1">MAHSAVVTGLPPLAGNAPEKTPKLMTRDEIEALIAQGKHVTIFHNQVIKMDAWMPYHPGGDKAMLHMVGKDASDEIDALHCFETRQKVLRYRIGRIEGTWENFLPPIQGGVYRTHEEIERANAGGESHKDQDSSAPSTRVPSPVFDEEETAGARQRKTNKKDGARAPSISSASSVEEPDLDGMSYLDTITREHISLDLDKYPPPDKETQATIVAKYRELHQKVYDTGLYNCNYKAYGIEFIRYTALAVGSAFCLRHEWYALSAFLLGALWHQLSFTVHDAGHMGITHSYLIDSCIGALIADFMGGLSIGWWKRNHNVHHVITNAPEHDPDIEHMPLFAVSHRLLGSLRSTYYERVMAYDAVAKVLLRVQAWTYYPLLALARFNLYRLSWDHLIMGRGPKKGPGLVIWWLEIIGQVFFWTWFGYGLVYNLLPDNWTRFYFVMISNITASPLHVQIVLSHFAMSTVELGPQESFPQRQLRTTMDIDCPEWLDFFHGGLQFQVIHHLFPRVPRHNLRATQKLVQELCNEVNIPYALYGFANGNQQVIGRLAEVSRQAAILAKCQQAIQNGDLSGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY99</accession>
    <name>S0DY99_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable DNA polymerase epsilon, calytic chain POL2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_13259</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429600.1">
        <property type="nucleotide sequence ID" value="XM_023575924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY99"/>
    <dbReference type="STRING" id="1279085.S0DY99"/>
    <dbReference type="GeneID" id="35406713"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13259"/>
    <dbReference type="HOGENOM" id="CLU_015981_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT67519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="849" mass="93415" checksum="C00E23E9A0F88C93" modified="2013-09-18" version="1">MNNLRRKDHRGAVDFNGPGHYHGPTARHRTVQAVSTPLTTPASIALSMSKTTVPPSLMSFDFFQQPIQSIHSDFNIGCYRSASPAKLDLGLESGTNWAGELDMREMSTISTISADTSSTGSIFSSVPTEFSDAMTVRNGRGRSRGPSPLSRGGRTNSTDNSTPSFVCLGPQCQRAFSSDKDLKSHVKSCHTYLCNWAGCDQPSFSTRDGLIYHVKVKHLVICPSPGCTETTFQSVRLLQSHIAMAHPEDGRDDAKEWELPAKMNASMKTGNRSSSSETPTTTLASLKRKNRDHDTDMSMDVVKTKHQCQDRLQVVVEKRARKNTGTPRSAESPTDLIRGRASRCIEVTSFSLVFEHAVLPFLSQYLPIWVGPRHVITVTRGKSPQMKRICIMAPRIISRARKIIIASHVQDLIPSNFSKLVTFAFTQGEINRTVTWARGLDKNHKDDICAARNPYFFRDPCMGDSIGVTGNGVFEDSTATLGPCITVGGGSYWLGNFHPFMEAYQQLAQVEVEHPSSQDRKRCIDEGHDAMAQETNFRLGKLEVTSGLNLKTTRISHDPYWDECDTDKPLVVTDWALIGARTSQANILRKFPSETQPPTQEPTVATTTTIVPGADVLSSGRTSGYQRGQICEIPAYVSGVENQTQKATREWFIEEPWPQEDEDAWIRGGIGVNGDSGAGVVDANTHGLIGQVWGRNNYWGPGQRVTYFTPIADIFDDIQEKCGQQSRPQLPQHRDEANCFPLHPSCRQCFDLRVYLNSSRRSSRMSLQSMIMGTGDGDQDLTSIEAVSELATPKDYHRHSGIEETLVSLSGIVSPAGPSGYPGTPMIADMKSPYATELDLGDLAGAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYN4</accession>
    <name>S0DYN4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_14644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429747.1">
        <property type="nucleotide sequence ID" value="XM_023576601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYN4"/>
    <dbReference type="STRING" id="1279085.S0DYN4"/>
    <dbReference type="GeneID" id="35408024"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14644"/>
    <dbReference type="HOGENOM" id="CLU_079104_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495357" description="NmrA-like domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="304" mass="33554" checksum="720F3E3141BCCF9B" modified="2013-09-18" version="1">MLILIAGITGMVGQTLARYALEEGYQVRGLSRNPDKLNADIASKLESFIVCPDFLDKSHLAKAVKGVDVVIAALPPVPSIIGAGQLALLLEAEKAGVKVFHAASWNFDWTKLELGDHETYDAYIAFKRLAELSCSLKPIYGFTGAILDYSLIHIKDAGRPSLVNAKTRSVVYFGTGEEKMSFTTLDDLAKYTLLAINDQDVLKRGVYYVESSHCTMPELADIYGKARGYEMKKQCFGGKAELQAMLQQARENIGAFQADKYIDLAYGMVFLNGKAVIDPVDNERWASKVTPTSMEQWLKEHPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYY6</accession>
    <name>S0DYY6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HOL1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429716.1">
        <property type="nucleotide sequence ID" value="XM_023576541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYY6"/>
    <dbReference type="STRING" id="1279085.S0DYY6"/>
    <dbReference type="GeneID" id="35407971"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14590"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF164">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="59212" checksum="3C9B1D5F2E8383B8" modified="2013-09-18" version="1">MGKDDNHGKAMNVEDAVGNSAGVLLYDNHGNVRNLPVPSCDPNDPLNFGIWRQRLVLLAVCMYGIAGFGVIQSTPLFFGNLIAEYMKETRGTFHPDRIADLASYPSLCMGLGNFFFVPLSMALGRRFAFILSNIIFVASIIWAAKSQTFESHLGARCLQGLTAGISDCLLPIIVLDMSFLYKRTARLIAYWALTAIGSSILLVPIPFIVENAGGNWRLNYWFWLAFAVFAMILIIFCVPETLFNRRAAELSGRIHATDAYGTHRTFASPQAARDAGFDIDDAQSENPTELSYKRQFALFTVQPSPVARFLGAYKDMFLCILIPGTLWVLLFNSMVFGGLVVLSLTYAQRLEMPPWNFSPETVGTVQVGAAIGALFGLGYGELAEPISRYLTKRNGGVREPEHVLPNFILPAIFCFLGMIIYGVVAADPTQYSWVGMHAAFALFYFGFCAISAVTGVWLGELLPHMSGPAIVLTCGGRNAISFGYSHSFNSWISAMGIRDTYILFGGILFALGSLAIPLYFFNGRIRRVMEKMTFIGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZC0</accession>
    <name>S0DZC0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable ribosomal protein S13.e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_02805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427909.1">
        <property type="nucleotide sequence ID" value="XM_023574580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZC0"/>
    <dbReference type="STRING" id="1279085.S0DZC0"/>
    <dbReference type="GeneID" id="35396287"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02805"/>
    <dbReference type="HOGENOM" id="CLU_090139_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="151" mass="16806" checksum="8443300533FB99B0" modified="2013-09-18" version="1">MGRLHSKGKGISASALPYSRSAPAWLKTTPEQVVEQIAKLARKGATPSQIGVVLRDSHGIAQVKLVTGNRILRILKSNGLAPELPEDLYMLIKKAVAVRKHLERNRKDKDSKFRLILIESRIHRLARYYKTVGVLPPTWKYESATASTIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZL3</accession>
    <name>S0DZL3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_13013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428928.1">
        <property type="nucleotide sequence ID" value="XM_023575648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZL3"/>
    <dbReference type="GeneID" id="35406469"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13013"/>
    <dbReference type="HOGENOM" id="CLU_025209_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="695" mass="79968" checksum="660E962D09346B55" modified="2013-09-18" version="1">MNKPWRLDDIVTWAIDDNQNERLTFAHIQGPPASRKAIRLPRKIIESPRILDHRRTIIVQVLPDFKRNVVVEGRGSWSPNHELKPGQRQPKLKVETYRESETMPDAEADRIIFLIEADPDYSAEYALTLATITSFALRKTSIQRALHIKIATVSWESIHPVTKQLFHQYSGLFTGVSEFLLAKYEREPAQPVILKEMPSDLLKYGTVSNDSGTICLRFRDAMYDAEDQDEGNTVPSQWDPWITMSTTNGHYTSFPPGVKEPGLKLQMIHLNANARIAELLPPSYSVSIFASPTVRRVIFDRRSHQLLHTFLWISESEKLQQLSWLYRSQSYHSPDVLCLDHFTKHRATERRMKIRNEHAEGFMAALLDYTQWPATIWDLLKIVRRKDDVFAHVGDRFIFQGLTLSQQDRPKLPPRLNNGRAFYSLLPQIDYDSRIAYFLTLESSPLIAMMRVRFAALLMSGNESLELLHIQRLDSGTKTAIQECLKGCSLVCDPGSWVHLSTLWATAGLASMIVADDGEDRAMTPLADGSIRVVTLASAFLSHFSQALDRILRANGMEVTELATFRESVNYENYKQISRDLLRVYSHQVAFTSKPRRKLKEGELPLLNDFMTKKIFNPNLNLAVIDWDYLFTQEKTVYGVYTHLKRLGNGGTTVCNWTWIPSGVWNEFQGEMEKVRKMKGRRDEKNSDEFWQTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZN5</accession>
    <name>S0DZN5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428024.1">
        <property type="nucleotide sequence ID" value="XM_023574719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZN5"/>
    <dbReference type="STRING" id="1279085.S0DZN5"/>
    <dbReference type="GeneID" id="35396412"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02930"/>
    <dbReference type="HOGENOM" id="CLU_055660_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="261" mass="29830" checksum="A34FCF73B24B3839" modified="2013-09-18" version="1">MKRSRELEEELDSDSEQANPEPSLRPVSKVTQLESAIDDEEDTIAMRCNLPPHREPLAFRSYDEYEVHYNKSHTNRCLECHKNFPSEYLLNVHIEEYHDPLVTVKREQGQHTASPIPWLPIDRYESATDPLRSSTRALSRDVSHMYPKNFFFAVTRDGIDGRRSLLNDGSHHRRRSSTNSQAIKNSRRRASLMEGEIVSSQPEDKSKEAPKSPAVKNVENKQEKHKPADTEMADLTGAMSSLSFVPPSVRFGRGRAGFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0G5</accession>
    <name>S0E0G5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430371.1">
        <property type="nucleotide sequence ID" value="XM_023577276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0G5"/>
    <dbReference type="STRING" id="1279085.S0E0G5"/>
    <dbReference type="GeneID" id="35400542"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07065"/>
    <dbReference type="HOGENOM" id="CLU_067853_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="304" mass="33172" checksum="D22B990110BC3E39" modified="2013-09-18" version="1">MPVTNRGVTQLTPDTTTSRSTQSNYLNKSSSSFQTLQAGLAIFAVAVIARFCVLRLYLWLRQMRGLDQHTLPISSLSHTRRLQSQPFWAMNEKTMTPPANQEDMAPEDMLHAKQEDKKLVIDPNWQSTDNLMSRHVMSRPPPAPPLTPPELSTAVFTFDDRPRPGEDSFIRQPNPDYMSSTANAVLPDNPPSTSVTRRRSYNKTLPIGVPVSQPSQRMSDTADLTFSPSSYPPASPLLPPAPPNAGTVEIGVQGEIIGVLDSEGAGWTRHTRVYGGGVCLACAASGGNHGGGFYGATVRPEEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0I2</accession>
    <name>S0E0I2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_13340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429233.1">
        <property type="nucleotide sequence ID" value="XM_023576015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0I2"/>
    <dbReference type="GeneID" id="35406794"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13340"/>
    <dbReference type="HOGENOM" id="CLU_013756_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT67152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="538" mass="59923" checksum="F0F2080B84557335" modified="2013-09-18" version="1">MAPQYHPVSSDDVELESHLDVPLLDLEPLEDDAVSDSESLHSHSEPIPSYRFSRWGVHSPKRIVFLIAVIKFAVVLSGMLLLLPTVRLIEDMFCHIHYQDTSTDIIDEMKCKVDEVQSQLGYLYGWNSLITSIVGLVVAFPYGMMSDKIGRKPTVMLAWSGIAVCFLFAPFSMKAFQGELREKPYLLIVGGFFQIFGGGIPVMFSTLYSIAADVSSEEDKAKHFLWLTFGATLGGISGPIIAGILMNKYGPWVPVYLVFATVPIIIGILCLLPETLTINLKHQKAQAGKSAPTTFKGHISHAIKDLKHSVSMLKDPSVLMIMVTFFVTNARFTAYTTTLGQYISKHFKWKMAEVSLILSPLGILNLIILAGLPKISEILVSPRFRMSAFGKDLFLTRISTGILAFAAFWQGISHNAVMFLFGLFIGTFGAADSPLARATVTHYVLPEYTARLYALIGMIEVIGSFIGGPVLAWFFDQGLKRKGVWIGLPWFYISFLCSLSWIALFFVKPPKKRSREDPTDSDGYEEDDYMPDDPLRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E138</accession>
    <name>S0E138_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_07273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430566.1">
        <property type="nucleotide sequence ID" value="XM_023577507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E138"/>
    <dbReference type="STRING" id="1279085.S0E138"/>
    <dbReference type="GeneID" id="35400750"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07273"/>
    <dbReference type="HOGENOM" id="CLU_112609_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000030">
        <property type="entry name" value="Coactivator bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="9">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT68486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="152" mass="16301" checksum="1E680C63D44ED8BD" modified="2013-09-18" version="1">MDDWDTTTKIGSRTRGSGAAQRETVVRGKAALNAAQRAGGLTTEKKYSSANAGSAPEGQRMTKVDRSDDIIKPNTIGKTVGDVISKARQQVEPKMTQKDLATRCNTTQAIVADFERGTAAPDQKVLGAMERVLNVKLRGSDIGAPKFPNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E165</accession>
    <name>S0E165_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to SGD1-involved in HOG pathway</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_13638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429508.1">
        <property type="nucleotide sequence ID" value="XM_023576346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E165"/>
    <dbReference type="STRING" id="1279085.S0E165"/>
    <dbReference type="GeneID" id="35407092"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13638"/>
    <dbReference type="HOGENOM" id="CLU_006786_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="640"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT67427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="866" mass="97274" checksum="385AC28A473C95B5" modified="2013-09-18" version="1">MTSAPELQQKLFKRMGLDVPEPKPQRNGTRRAGQQLSRKEQRKAQRVQKRTHVYARATPQRPQHINHAQRRPNTTQRKEQVNKSQSRSPKQVSDDEDDLEDEDEDGAGDVSLDEDDGLDDLMDDEEDDNDDDEEEEEKKNTKAKSGKKGVSKAAQERLAQDDAEIEAFERKLGIKKGRKSLPQSFREDGLGDLLGNLSGEEDVSDNDNDNKKRKSEYDDWLASKRRKTVEPAGRQKVRDVPENEERDDDTGLDDESGDDDEDMDLTDEDDEDGGDFDNDDEEDDVTDTTPAQPRQRENPYVAPTTGVTVAKYVPPSLRRAANSEEERKSRLRKQVQGLINRLTDANILSIVKSVEELYQNNARGDVTDVITDAIMAQISKPESLPDQFFVLTGGFAAAIYRLIGSSFGSVSIRRIVEDFGGHYEQASKGQNAESAIQKEASNILTLLSQLYVFEVVTCKIIFDYMERLLSDLNEINVELLLRICRMAGRMLKQDDQQSLKHVSGVLNQSVSKVGYTNISARTKFMVETITDLTKGKKKARGLDFTVVSEHVQRMKKRLGELKSQSRRLDGLAPMGVGLVDIEGAETRGKWWLVGASVPTTLLDKSKKGHVSDAEMSDHEDMDIVLPDYPKKARAQGLSGTAQIAIFTALMTASNFEHAYRQFVNLRLKKDDQLALATVLVQCVGSEMQYNPYYALVGGKACLSNSRIRFAIQDRLWKIFRSLGESMFGEAPEEDESADAERMKDERRIANVAKFYAALVADGTLNIAILKPLELPEANHWTSMFVQLFILALLKECRSKKKGTEEDTKLKKIFGVARDLPGLAAGIHWMIRKKVRRTKLVSAKESKKLEGVCEKAQIIVRPAAIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E176</accession>
    <name>S0E176_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA (Uridine(2843)-N(3))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430674.1">
        <property type="nucleotide sequence ID" value="XM_023577637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E176"/>
    <dbReference type="STRING" id="1279085.S0E176"/>
    <dbReference type="GeneID" id="35400868"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07391"/>
    <dbReference type="HOGENOM" id="CLU_028833_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44000" checksum="8A9AA9EED8B5288F" modified="2013-09-18" version="1">MVKKTGPSKKTAPSKQSLSSKQSSRKSSAPLETSSPALQSEQQQQRLLNIFSSAFNNVLTSADFSRLLQEIKQALFNREFAAAFGREDYLEAYAARWSPTRALCYATVFLSIKKHLDGTLIDKEETKDDTNTTKERLASHTEIAGSTQDDANDKSEGTGLEIFQDLKLDSTSNRRNATLRMLSVGGCAAEHVAFASYLQTTATDGHLTLLDSGPWTRVISLLESSTVNPPPISKYASTARQAANHPLLGKNQLSLDVVQRDVLDLDVDSLSAQCANGRVPIILTLLFTLNELYTTAGIGKTTKFLKNLGQVLASDSLVLVVDSPGSYSEAALGKEKKRYPMQWLLDHTLIETETPGYSWEKLQSDESIWFRLPEGLSYPIPLENMRYQMHLYRLQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1N2</accession>
    <name>S0E1N2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_07587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430854.1">
        <property type="nucleotide sequence ID" value="XM_023577856.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E1N2"/>
    <dbReference type="GeneID" id="35401064"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07587"/>
    <dbReference type="HOGENOM" id="CLU_000504_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043008">
        <property type="term" value="F:ATP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170011">
        <property type="term" value="F:stalled ribosome sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904689">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071264">
        <property type="term" value="P:positive regulation of translational initiation in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990611">
        <property type="term" value="P:regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006448">
        <property type="term" value="P:regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1335"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1512"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1655"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1974"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2626"/>
            <end position="2666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT68774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2666" mass="289902" checksum="A57CBB011BDB1532" modified="2013-09-18" version="1">MSKGDSSDSGAPAPLDMAVVKQALSSSSTAVRITHLRTIEDKLAQKYRQSRLSVQKCLVALISSGADSNTIAPLITALRKESQKPGIAPTNAFVLVEWCSLFMQYLDASQWDQFATDIILADADALEKCHQPVCRKSVTHSAIIVTRRGLRKLFSSNELSEKRLSASVDVLTAKGAQSISRNAVLLGVIAGVSARKDHLRPVLDSLKSRYYDFFTREIIGSRTSVPEHLVLGLGNFFASFATLEEISKELIPALEKGLLRAPEVILGGVVTPLVRCLPENFDLSKILEQNLLKPLLSNAKSTNAAIRAGSLDAFSALVNKSGDTASLEKVINEVATPLKSGKLASPDHRVLHAQMLQTAPLSKASAEQVANAVAVIAAKEGNESALAAETSALAKAVSFLLTNDAEVPKSVLESVTKGLTEKKIPSRKYWLLRVGGILQTLNEAQSVSSAMAAFVDAVIPKLITTFTEVTSNAASAAQNGLIVGAYILTAVSTHINRVLPGSAADLSLTKAVVTKQSLSLDPKSSFLLSPRIYSKVTAEEDLKWFSRAMNSIFQGLDKEADNQIALAWSEAIIHLVTAQSVPATVQQETSKTLSSLYVRSPKLVSGFIIAGLWDYLKHSGSPEKEPSSGAHNLIQVVKAICLTPSDIEKSGETINTEDLEAQANNLLVLARPELIPRANWIDLCLRMELDPGNLVKEYQDELLTEIENQTSFSQKVSMTLPGYRNLINLYRQVDAIKKAAYNAAADLAFVAPEAIIPRLLETLSRDLNAEQLHDVGPVEAAIFRTPEGTVFVDVLAKKSQQVLDKNKKDYDILKWEEELRSQLERKKGQQKKLTPEENAKVNAQLKKESLIRQSIAEIEAKLLRGIGIIRSLATGPPTDAAQWLGTAVSLLIDIMDAGATMITGDAAPLAYITCAKKVTERLGSMRPFVGVAALRLRGVSLADNYQEEAVEDLVTRVLYRLRFAGEQRPFDSVSLIYALPLVLELLRKGGVGDSPDDADAQLVLAIEFLSYHTDVCSDEAVPRAELLSVLITSMQAYAQHYKLLRDCFADMCRCIAPNMDRDEMVILAKGALVPEARVRSTVLQSISAEIDMSELGYSSEIWIAAHDDEEENQDLGREIWEESGFEVTPEVPLKMLPFLESKDGQLRRAAARSLSEAASLHDESLPAVLDQLKATYVELAKPRVQQLDEFGMPKKMDLSDPWEGRQGIATAFKEIAPVFKVDQLDPFFDFLIDAGPLGDNNDAVRGEMLDASIMAIEIHGKGILDELMSKFEQTLEQPDKNSDAADRVNEAVIIMYGALARHLSPGDPKIPIVIDRLVTTLSTPSETVQYAIAECLPPLIRACPDQSSKYFGQIMEQLLTSKKYAVQRGSAYGLAGLVMGRGIAALREYRVLSTLTDAMENKKEANQREAALLAYELLSTMLGRVFEPYVIQIVPQLLTGFGDANANVREACLAAAKSCFAKLSSYGVKRIMPTLLDGLEEQQWRSKKGACDLLGAMAYLDPQQLANSLPDIIPPLTGVLNDSHKEVRAAANRSLKRFGEVINNPEIKSLVDIILKALSDPTKYTDEALDSLIKVQFVHYLDAPSLALVTRILQRGLGDRSNTKRKAAQVIGSLAHLTEKKDVVMHLPVLVAGLKIAIVDPVPTTRATASRALGSLVEKLGEDTLPDLIPGLMQTLKSDTGAGDRLGSAQALSEVLAGLGTTRLEETLPTILQNVESSKPAVREGFMSLFIFLPVCFGNSFSNYLGRIVPPILAGLADDVESIRETALRAGRLLVKNFAARAVDLLLPELERGLADDSYRIRLSSVELVGDLLFNLTGIKAGTEAEDIEEDENIKEAGASLKETLGEEKRNKILSALYVCRCDTAGAVRSAAIAVWKVLVHSPRTLKELVPTLTQLLIRRLGSSNMEHKVIASNALGELIRKAGDSVLSSLLPTLEEGLQTSTDVDAKQGICFALRELISSASPEALEDHEKTLISVVRTALTDSDENVREAAAEAFDSLQQIFGKRAVDQVLPFLLNLLRSERDADNALQALLTLLTETTRSNIILPNLIPTLTTPPISAFDAKALASLSKVAGPAMNRRLPNIINSLMDNEINCNDDGLREELATSFDTVIQSIDEYDGLNTVMNVLLQLLKHDDHRRRAATARHLGNFFAAASVDYSRYNQDIIRSLLNSFDDRDTDVVKTAWVALSAFTKKLRKEEMESLVVSTRQTLQRIGVAGANLRGFELPKGINAILPIFLQGLMNGTADQRVQAALGISDIVDRTSEASLKPFVTQITGPLIRVVSERATEVKSAILLTLNNLLDKMPAALKPFLPQLQRTFAKSLADPSSETLRTRAAKALGTLIKYTPRIDPLIAELVTGSKTADPGVKTAMLKALYEVISKAGANMGEASRASVLSLIDMDTDERDETMTITNAKLLGALIKNVPEEAAHGLLKNRVATSHFTHSSVLALNSVLAESPDALLQSALADDLPDLLCQGVTNKNVFVADNCILATGKYLLSDSPKTFETTKGIFEALASVIQPGNATDSRRLALVVVRTVSRNDMEMVRPHIALLAQPIFASVRDPVIPVKLAAEAAFVELFNVADEESRIFDKFMAGHGADLPANTKRSMGDYFKRVAMRLGSQARERREAEGGQGGLGLSNDEAEDEKEIWSVGKVDVGSEAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2A3</accession>
    <name>S0E2A3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to stress responsive A/B barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428879.1">
        <property type="nucleotide sequence ID" value="XM_023575592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2A3"/>
    <dbReference type="GeneID" id="35406419"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12963"/>
    <dbReference type="HOGENOM" id="CLU_120569_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="106" mass="11983" checksum="0C503B5B4AC25A4A" modified="2013-09-18" version="1">MSGKITRVTLFKIPKAEDQQHLIDLYKQMPQKATKDGKPYIVSVQAGKAKADQRSQGFTIVAISTFASQEDFNYYDTQCTAHLELRTFAKSVNEGVAMIYFENEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0E372</accession>
    <name>S0E372_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="8" type="ORF">FFUJ_07820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E372"/>
    <dbReference type="STRING" id="1279085.S0E372"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07820"/>
    <dbReference type="HOGENOM" id="CLU_026505_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT69261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="437" mass="48253" checksum="83E5DD39EC2513EA" modified="2013-09-18" version="1">MREFMDYVHSAFYEATGWNRDNSYAALNVTSDALLNFETPRGLRLTLSALASPNFATSYQLGSVGIVDGSISYLFSSVPLRLLLTPQSEAVNLPELLRSYRPLTELPHRTNPLLQAPKDKPESSLLYGRLYLPQSLLEALFVKRLSPALQVQLSSVSAQHLKNGGTVLGLAQYDVGKYALEGLASSDGGLLGFRGVYNFGGDAEKPEDQAANDNGNADRERIYGRFSTGGEIYYGTLNKSGGISVGTRFATLPAHKGTPLSATLTLNPLMGNISASYAVVAGRHCSLATRMEFNVFSYESAWAIGMELWRKPFTRLVLEDEPVIDDKLVLDDKPEVKRPKERSFQAKLEWRLDDPEPVIVKPPPPPPSPPKEEIDPEKPGEERYAGVLKTRLDQNMRIGVLWEGRVKSLLFSLGSSIDLNKLDKPFRTLGLEIQFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3R7</accession>
    <name>S0E3R7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_06917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431415.1">
        <property type="nucleotide sequence ID" value="XM_023577111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3R7"/>
    <dbReference type="STRING" id="1279085.S0E3R7"/>
    <dbReference type="GeneID" id="35400394"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06917"/>
    <dbReference type="HOGENOM" id="CLU_005024_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF19">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="617" mass="69216" checksum="4DE7744D2C2BC269" modified="2013-09-18" version="1">MRTTIACERCRRSKVKCRHNDQPPCAGCIKSGCTETCVLGGPVLGQSSGPKRPAKRQRLSVDQSRTDVSGDVWQDVNQVFDQTPRAQVISAINLFRAQFPEFGFLHPDDLEYRQDELSVVQKLRLLVIVAVSHRYTDAYTADINNKNILFIANEVQKRVTSGPSLALIQTFLILSLCNWGDGDGFNAWMHCGIATRMAQGLLSTGFASCGKRETLSELEKRTLWTCFKMDRLLSCGKRRQAMFADGDMHFSLPVNDTQFLFGQTPQPTTVDDSLRSHGPDDHLVLLIRGLRIWSRIHTWIAEGGRRQPGMTEPEQCPFNETSDWSKMKQDLIKWRGSQDALMKYPATKVSVHAQRGQAERFGYINLVYYVSLLFLCREFIPFSPVDEVIPRGPIEPPLLKARGPDSFWLQNVFDLYDAASQISSLLCDLEHVGCPLRTPFSGLCAFSSTLWSIYGAAFPNFMGFTPSQTSDADAQAERTMAVLVRIGKVWRLAEEWIDVLNTAKSIMTRVSEGRRVKKSRYDYPELEDSIHLAPLQGMPRQTFDRPAGLVSADDGSKLHQLVAGDAEQGMEADGLGFLEETSGSEFVGEDWWRLLSFCDDPHLLSTSMDNMGDENVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E463</accession>
    <name>S0E463_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431550.1">
        <property type="nucleotide sequence ID" value="XM_023578558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E463"/>
    <dbReference type="STRING" id="1279085.S0E463"/>
    <dbReference type="GeneID" id="35398836"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05357"/>
    <dbReference type="HOGENOM" id="CLU_003291_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050229">
        <property type="entry name" value="GlpE_sulfurtransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43031">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43031:SF1">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="371"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="459" mass="49376" checksum="091E519EE58E2C94" modified="2013-09-18" version="1">MPRRIIIIGGVAGGMSAATRLRRLDESAIITVFEQGAYTGFANCGIPYALGKVHELLSDRDAKYVCVIEAGFIGIEVAENLRKLGLAVSIVEYGSHIFPPIDGEMAEILHSELRDNGIQLFLNESAQKIDKSRITLSSGLVLPADLVILAAGVRARTGLAKQAGLVLGATGVSVNTHMQTSDPDIYAVGDMVETQNNITEKPAMLAMAGPANRQGRMAADHICGKTVNYRGNVGTSVCQVFGLTLGFVGLSTQVLRQLGHDPLSITVHPPDHAGYFPGSHTMTIRLAFRKETGQIMGAQIIGKAGVDKRIDVLATAMQFGSTVFDLEHLELGYAPPYGSAKDAVNMAGFVASNVLRGGCKIVHAEQLTREKLDELQVVDVRSPEEFARGHLHQAVNLPLNNLRQQLATLDRSRSTMVYCQVGYRGYLAYCILKQFGFDVVNLDGGFKTVVQGGCQSLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E473</accession>
    <name>S0E473_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430557.1">
        <property type="nucleotide sequence ID" value="XM_023577496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E473"/>
    <dbReference type="STRING" id="1279085.S0E473"/>
    <dbReference type="GeneID" id="35400740"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07263"/>
    <dbReference type="HOGENOM" id="CLU_007315_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000065">
        <property type="entry name" value="PX domain protein (AFU_orthologue AFUA_2G07450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="3">
        <location>
            <begin position="199"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="754"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="754"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1090" mass="119023" checksum="84B869B1A05A99BD" modified="2013-09-18" version="1">MSSTAFPNQNAPQPGASFTNPSKPKVIALNGSPLPTLSQTQDDDKPLLTDKQSDANNLANKMTATNDAMTSDNPITNSTRTETSNTRTATEDGTPIAKVIHFFATATSESLAGVAVGFAAFTYFTMGRLGLVLIGALGGVAGFISWEARNPELAKAVRRERGIDVIDRLLEAKNNQTGEKREDSSDDEEPALKNFDEFRPETREALGGLVDAIVRDYVKWWYSPIVPTDHSFPLACRKTLTSYLLSVSSHLSRKRPADAFLDLLTNSSSIIIVFMSELASAFSELPPDSSMTAADAVYNYLASNPDCHLANLLNQRQQASKFKMVAEDLLGFLDRNAYNCDPARVFLREILANSVLEKTLHTCSQADWINGWIVYLLEAGEPNLNQAIDVGMQRAPESSVVATNAFADLDGNVGNVGIAKPGRSSLETERARRKEPLGHKKKLSKAEEEMDEAMQEMKRMNDMIAEEEARRKRASVVSFHDSSKDLNIAEKRLSGAPDLSAATKHDVPLPSATSTEGFSSKSDIVQTPVTPRSPMDSSSPESSPRQSDGTRFTSFDQIVPPGQVADEGEEDAPKKAPLTLHNATITLHDDTPGEPNRIRSKPNWDYWVQVEPSATAYPGWMIVRRYADFETLHEILRRIANISGATAFTELHKDLPDWKLHTRESLRGELERYLRDACWYQSLAESEGMKRFLEKSKGHTHSESKAGFGWETMGKGMLDALTSGPKGAMEGGKSLVGGVTGVFGSTFSGLSRKSTQSVDLTANSSRLSISTPPSQLSGVRSPVRSARDSMDSQRSSIVSLQPGKMPPMERRPSYQSQSESDADIRTSRSECKESASASASALPSREHSRAPSLAQLRSPSAVSLDFTKLPPPPDQIPDDYGLPEANIDSQSAKGQQDRKAPPQIPTPPPSMTDGKRASLKPGKQYTPLSEPETRVAVELLFAVINEMYTLSSAWNIRRTLLAAAKSFLLRPGNPSLLTVQSLIQKSVIDANTSDSGIAEQLRKIRENMMPTEHELAGWPAELTADEKEKLRVKARRLLIQSGLPAALMGVMGQAATGEALGRVFDCLQIEEVARGLLFGLILQVVRIVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4W7</accession>
    <name>S0E4W7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_05848</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432003.1">
        <property type="nucleotide sequence ID" value="XM_023579106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4W7"/>
    <dbReference type="STRING" id="1279085.S0E4W7"/>
    <dbReference type="GeneID" id="35399326"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05848"/>
    <dbReference type="HOGENOM" id="CLU_027174_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000053">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="300"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT69924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="470" mass="51697" checksum="E685E89604E987B0" modified="2013-09-18" version="1">MPVTTFDLKEKYRYQNGFNCYLESEAVDGALPIGHNSPQKPPYGLYAEKLSGTAFTAPRHENKQTWLYRVLPSCAHPPYQEDKKSAGDTNKTLDGAEDGKLYYIPNQLRWDPFDHNESKDLDFVTGLRLVAGAGDPTLKEGLGMYIYAAGKSMDEKSAFYSADGDLLIVAQEGALDIRTEFGWLLVRPMEIAVIPRGVKYQVHLPSGPARGYALELYQGHFNLPELGPIGSNGLANARDFQSPVACFSEDFGATASEGSNKYTVSVKFNNNLFKTVQAHTPFDVVAWHGNYYPYKYDLGRFNTIGTISFDHPDPSIFTVLSAPTNTPGTAVADFVIFPPRWLVGEDTFRPPWYHRNTMSEFMGLIQGGYDAKKGGAGGFVPGGASLHNVMSGHGPDAESTEGARNAELKPAKVGTGSCAFMFESCLMVGVTQWGLRTCQKVQEGYNEESWGGVVNHWKMPEGLKVKPHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E502</accession>
    <name>S0E502_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431921.1">
        <property type="nucleotide sequence ID" value="XM_023579009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E502"/>
    <dbReference type="STRING" id="1279085.S0E502"/>
    <dbReference type="GeneID" id="35399239"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05760"/>
    <dbReference type="HOGENOM" id="CLU_080664_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="110" mass="12204" checksum="21712D6950F8635E" modified="2013-09-18" version="1">MSITHTVLFQFKDSVDQKDVTKTCDDFLQLKDLCIHPTSKKPYITSLQGGKDNSPEGMQNGITHGFVATFESAEDRDYYVKTDPAHQAFIAQVGGLVEKAIVVDFTNGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0E519</accession>
    <name>S0E519_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_07618</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430882.1">
        <property type="nucleotide sequence ID" value="XM_023577890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E519"/>
    <dbReference type="STRING" id="1279085.S0E519"/>
    <dbReference type="GeneID" id="35401095"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07618"/>
    <dbReference type="HOGENOM" id="CLU_006949_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000260">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="25"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="13">
        <location>
            <begin position="679"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="820"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT68802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="957" mass="106649" checksum="1D87651596F26547" modified="2013-09-18" version="1">MSGFLENAYSLVHQDNAADVPTVSDLRMQLEKGTDETKVETMKRILTIMLNGDPMPSLLMHIIRFVMPSKYKPLKKLLYFYYEICPKLDSSGKLKQEMILVCNGIRNDLQHPNEYIRGNTLRFLCKLREAELIEPLLSSARSCLEHRHAYVRKNAVFAIASIFLHSPSLIPDASELISTFLEGESDGVCRRNGFAALVSIDHDAALVYLSSVFEGIPNAEELLQLVELEFIRKDAVQNSQNKARYLRLIFDLLEAGASTVVYEAASSLTALTNNPVAVKAAAAKFIELSIKEADNNVKLIVLDRVDQLRKKNEGVLDDLTMEILRVLSSTDIDVRRKALGLALEMVSSKNVEEVVLLLKKELSKTVDQEYEKNTEYRSLLIHSIHQCAIKFSEVAASVVELLMDFIADFNNASAVDVINFVKEVVEKFPNLRTTIIERLVSTLGEVRAGKVYRGIMWIIGEYSLEEKDIREAWKRIRASLGEMPILASEQRLLDSHDTEEQTDDHINGASKPAAPSGSRKVLADGTYATETALTSQSSAAAKLEAVKTAQKPPLRQLILDGDYYLATVLSSTLVKLVMRHHEISSDQARTNALRAEAMLIMISIIRVGQSQFVKAPIDEDSVDRIMSCVRSLAEFEQKKELETVWLDDTRKAFRAMVQVEEKKRAAKEAFEKAKTAVQVDDVVQIRQLAKKNTTEGLDEIEVDLERATGGEGTAEDLSSKLSRVVQLTGFSDPVYAEAYVKVHQFDIVLDVLLVNQTTETLQNLSVEFATLGDLKVVERPTTQNLGPHDFHNVQCTIKVSSTDTGVIFGNVVYDGAHSTDTNVVILNDLHVDIMDYIQPATCTETQFRTMWTEFEWENKVNINSKAKSLRDFLDQLMACTNMNCLTPEASLKGDCQFLSANLYARSVFGEDALANLSIEKEGEDGPITGFVRIRSRSQGLALSLGSLKGLNKIGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E559</accession>
    <name>S0E559_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_07662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430922.1">
        <property type="nucleotide sequence ID" value="XM_023577940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E559"/>
    <dbReference type="GeneID" id="35401139"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07662"/>
    <dbReference type="HOGENOM" id="CLU_1959773_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="128" mass="14312" checksum="E23CFB82B48C053D" modified="2013-09-18" version="1">MAQENFSRQMSDVSSSFVELMYEVNKRGNLPGWPETSKLQSLRSDYNSWVRNHGMGLDSGISNSAPNYPSEALVKRSAIRLALSTLNSQIQLLMQDYRDGPDVRTASGAQSHTSSVERNLTILSRWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0E690</accession>
    <name>S0E690_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uridine/cytidine kinase</fullName>
            <ecNumber evidence="4">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_07804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="4"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431327.1">
        <property type="nucleotide sequence ID" value="XM_023578097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E690"/>
    <dbReference type="STRING" id="1279085.S0E690"/>
    <dbReference type="GeneID" id="35401281"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07804"/>
    <dbReference type="HOGENOM" id="CLU_021278_0_2_1"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="9">
        <location>
            <begin position="34"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="260"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT69247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="455" mass="51314" checksum="97356FB38DD848DA" modified="2013-09-18" version="1">MSASAIPEVNGGLESHVTVQKRAYYSPPWADVSIIGVAGSSGSGKSTLSQAIVKKLNLPWDSFYKTLTPEQSKLAFANEYDFDSPDAIDFDVLVDKLRDLKAGKRAEIPVYSFAKHSRLDHTTSIYSPHVLVLEGIFALYDPRVLELLDMGIYCEADADTCLSRRLVRDVRERGRDIEGIIKQWFGFVKPNFEKFVEPQRKVADLIVPRGIENRVALEMMVQFVEKKLFEKSRHHREALSRLEAASKDSPLSERVVVLDDTRQLKFMNTILQDIDTDPEDFIFYFDRLASLIIEQALNNAHFEAKNIVTPQGYEYKGLVSTGEVCAVIVLRGGSAFEPALRKTIPDCRTGRLLIQSDYSTGEPELHYLRLPDDIADQESVLLLDTQMATGGAALMAVQVLVDHGVKQDRIVLATYSAGKVGLHRLTSVFPEITVVVCNMLDYQQERWVEKRYFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6G6</accession>
    <name>S0E6G6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">NADPH--cytochrome P450 reductase</fullName>
            <ecNumber evidence="18">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_06851</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">This enzyme is required for electron transfer from NADP to cytochrome P450.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="18"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431412.1">
        <property type="nucleotide sequence ID" value="XM_023577038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6G6"/>
    <dbReference type="STRING" id="1279085.S0E6G6"/>
    <dbReference type="GeneID" id="35400328"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06851"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0521">NADP</keyword>
    <keyword evidence="12 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="19">
        <location>
            <begin position="79"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="284"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT69332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="700" mass="78209" checksum="D2072EB1C57E1FB1" modified="2013-09-18" version="1">MEAETVTAPGDVPVFDMMPAVLTAVLVSLIAYFGHGPLHELLFQTSTKTKSLGADSDDESDVSSDKCIVKRLEEEEKNCVVLFGSQSGNAQEFAEKLGREAHTRFSLRSIVAEIDDYTYQNLHKLPENTIVFFILASYGDGEPTDNSEQFYNFLTDEDDDGPFDRLREHGLQNLSYSAFGLGNSSYAHFNAVVRKVDERLQLCGARRLGPVGEADDGKGTNAEDFIEWKDKMWPQVMEAFGLVERDAGEREPAFEVVEIPNHHGPIFQADYTDRNLAQQAQAVTNHCFAPISDSKLLSDAGGRSYIHVELDIKNTKLDYETGDHLSVSPINSDIEVERFLRVFGLWDKRHETIRVRSLSDDLNPPFPSPCSYESAARFYIDICGPVSREVVSAFANSVSNAKQKTTLRQLGKDKEAFLALTEGSYYNVASMMETLFPGETVDVPFAIIIEAMPKLQPRYYSISSSSALDAGKVSITVAIESFPIQKTNRHFSGVATNFILDAASTGNEVLSRSRMQPIPYTLTTKRPHLQASLSTFVRTSTFRLPSDPTIPILMVGPGTGVAPFRGFVRERVAMHRQGTSFAPMTLFNGCRKRTEDFLYEKEWKAYASELGSKFRMYTAFSREQKHKVYVQDLILQQSKDIASLIQNGGHVYVCGDVGMGRGVTETLCKVLASETSMSLDDAQRELSDMRHSHRYQEDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0E846</accession>
    <name>S0E846_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to SYP1 Protein with a potential role in actin cytoskeletal organization</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433133.1">
        <property type="nucleotide sequence ID" value="XM_023580341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E846"/>
    <dbReference type="STRING" id="1279085.S0E846"/>
    <dbReference type="GeneID" id="35402382"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08908"/>
    <dbReference type="HOGENOM" id="CLU_011037_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09264">
        <property type="entry name" value="AP_Syp1_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07650">
        <property type="entry name" value="F-BAR_Syp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000102">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049609">
        <property type="entry name" value="Syp1-like_MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="3">
        <location>
            <begin position="617"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="845"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="845"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="890" mass="96361" checksum="DA18C6E6A8092C0B" modified="2013-09-18" version="1">MEDMARAEYPAMLATLQPSQAVHTLTERMKRMSRVNTEIADWLQERRRVEDQYVQGLKKLATFKVPNSQSELGVFQAPWNRIIDSTENIAHSHHQLADRIERDIEHPLRNFANRKDVQNMNTMSSNLTTMARDLEESQNQVDKLTKKGSRANTSKVDAASSKLESATGQWESQAPFIFESLQALDESRVNNLRDLLTQYQTHESDSAGRVQENAMETLALMLEIDTEKEIQSFVHRATAGKAKLPTRTSTRQSSFAGTTPSTPVPPSTADSTNLPAQSAHTSSPAPVPAPASSHAGDDDISEHNSVPQEKPGGKLRRLGTMFGGRRRQSMHAGFGQLSPGKLGPSFGRMGTSHSQNERGVSPRGSSNNLAEHHRLSSLAETPDVPKLPNNETDSPRPDASHENTNGVSHNGNLLDSPIPHTTGGTVNGNHEPDLSDVQPPPGPPPSHKQENQSPAPPQLATKDAEGFTVPPPMNDPISEAQREAKESGEDPDQLLKVNIQQTPVEDEDPEAKMAALSSVANSLKLGPATRRSGTVRGRRDVRHTMYVPPPNLPESGTDSSLSARPTSPSFAQSLSKGSAVAALASEASIAGTSDTQSVRSGNSLGGLNHPQHAHMTAPGLNTSIIESVSATFEDGVVKSTTITGEIAFVNNPSDSGDTKSYQTIRINNFSALERIGPNRIFVNSSPDHNDQFTMGLDHLSNNTPAFSYRVFSEDSETPSLGEHAPLSLKPAWKPQGDKLGLLLQYQLNPSSKLTAPVTLHNVVIVATYEGKSSGAQTKPVGTHLKDKHLVYWRIGDLTLTTEPHKIVCRIIGAEGAEPKPGHIEARWEFTATGDQVIGSGISISRLDEGKGKGKDVSEDDPFADDTASTEHKWVDVPISRKLVSGKYEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8E4</accession>
    <name>S0E8E4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to 1-phosphatidylinositol phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433238.1">
        <property type="nucleotide sequence ID" value="XM_023580466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8E4"/>
    <dbReference type="STRING" id="1279085.S0E8E4"/>
    <dbReference type="GeneID" id="35402269"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08793"/>
    <dbReference type="HOGENOM" id="CLU_024117_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="2">
        <location>
            <begin position="76"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="348" mass="39183" checksum="6D9A8ED999529064" modified="2013-09-18" version="1">MVAISGFRSLSTPVNRTRRLPMILGGGAFFIMCIIYLLLSIAPCMVYGNCYRGYSSAYSFDADLAHNPTWMADIPDDVFLSSLSIPGTHDTMTYEIGSETLQCQNWNLTTQLEAGIRYFDIRARVRDDELHIYHANGYTGFSFEDVVGYMNDFLDRNPSEAIIMRLKQEGNGIGDNNTLSFEAAFNKYPLGDRLYNYSASEPLPTLGSLRSKIFVLQNFPAWRGGPYGLKWEGHQMILEDIWIIPDIYHLSEKWTAIRDALELAATAALDNKVLYLAHISASVGVLPIEAAAGPMNRTVTGMNDMTGQWIKDFEDNEDTTRTGIVIIDFPGKKFIDAILRWNKSYTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8U7</accession>
    <name>S0E8U7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable DUF895 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_07729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430983.1">
        <property type="nucleotide sequence ID" value="XM_023578014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8U7"/>
    <dbReference type="GeneID" id="35401206"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07729"/>
    <dbReference type="HOGENOM" id="CLU_030884_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT68903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="472" mass="51953" checksum="3B9C20A43067DA67" modified="2013-09-18" version="1">MTVVENRHADSEVAAPPKDQLLPVKRYRSTFFNITVLGLCNLSAPGIWVAMNSLGAGGAASPKLINAANALTFCLMVVSCYFSSTLVRYIGIKGALIFGTLGYAPYAAGLYTNNRFGTEWLVLVGAALCGISAGVFWMAEAAIAIAYPEPWNRGKALGYWLTYRLSGQILGGAINLGLNADRNEAGKVSYTVYLIFIALQAVGPFVALLLSKPHQVQRKDGVTVKLEIDKLPSFELKETARLFFTKKFLLVVLFIGQAVFAESVFFTYLALWFSVRSRALGSFLGGIVAVTAGNILGAWLDRTKVSLRFRTRSSFAFLATLQGACWIWATVLVTRFRETRPTYDWVDSGFGHSFAIFLFLTLSFQLNYLFLYFVIHHLANTQDEIIRFSALLRGTESAWQALSYGITSLPLFAEVGGVYFNFALWGLSIFPAWLVLKDFGSHAAPSLESPIQEVDSQKYGSNSGEDSDIKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8V4</accession>
    <name>S0E8V4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433388.1">
        <property type="nucleotide sequence ID" value="XM_023580645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8V4"/>
    <dbReference type="STRING" id="1279085.S0E8V4"/>
    <dbReference type="GeneID" id="35402107"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08631"/>
    <dbReference type="HOGENOM" id="CLU_047269_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF2">
        <property type="entry name" value="ALPHA_BETA-HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="422" mass="47861" checksum="ECAF416691E27AB7" modified="2013-09-18" version="1">MILGPVSLVDCGVFLMFLAPQLIWHAGFFLTLFTGLRALPFLLIRLPYEFVTDRYLTHSTRQLAFTQTATVFEDLVIRCVRYAFSNIPAKVGRVFFGKHVALPFIHWRMLRHGYVRSPVHYREYHIGKGDIKSKGTWIMHQPEHRPDFVLYYAHGGGFLMGSSYFYLEFLMAWHHLLIEAGFNNPAIFALEYTLVPDQVYPRQVLEALEGYKHVLEVVQDASKICVSGDSAGGSLILSLLLELGAQAGNQDKKGIKVNIRSGLSDADPPHLPLPRMATLISPWITLMSNLHYSSKSDFLDKRTLWKYAHEYAGENMVQQQPASPGDCVDEGLWRAASPERGYFIVFGEEEVFAPDIEGFLKRQAKIGIQAEGQKFDGGIHAWPVASLFLSSTEDKRLQGLRAAVKEIRRRMLEWGTLNEDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8Z9</accession>
    <name>S0E8Z9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431028.1">
        <property type="nucleotide sequence ID" value="XM_023578065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8Z9"/>
    <dbReference type="STRING" id="1279085.S0E8Z9"/>
    <dbReference type="GeneID" id="35401252"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07775"/>
    <dbReference type="HOGENOM" id="CLU_030169_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF7">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="87"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="399" mass="44360" checksum="ADB17D08B6BA6A5E" modified="2013-09-18" version="1">MGDLPHLSDHIGKFSLSSIHPADPAYTPLLYRLREETFQNRTTQVRHGSYLRRFTRDTSFNTAEAIKENSGIDLNNFMRRYGLTGCVVVQNGAIKLEEYRHGNSQASRNDVQSVTKSFVATALAIAQQEGKLSVDDSVSRHVEELKGTAWADVPLLALSSMSSGVVEQSEEERPADVPNPMYATELYPQTDPEAVINWLKTSRKVAEPWEEFHYYNPNYYVLSTAISRATGEPLNEYISRTIWDPAGMQYDGYIRTTGAGHVDGHGGLSITLTDMARFGCFILESFRDEGKGPNVPPGWFQDISDAKNSVGARALQPDNFVSNFGYESGWWTTGRGGKEYKMGDDGAFAAIGMYGQSIYVVPKLDAVIAIQSGYPEHELDLFTKNAELATAILKVLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9F9</accession>
    <name>S0E9F9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="573"/>
        </location>
    </feature>
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        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="428"/>
        </location>
    </feature>
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            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT70402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="573" mass="65781" checksum="B228BABA57F0798E" modified="2013-09-18" version="1">MSTLSPSVEAASDEVYPLSNSNNLDDNVHAADNPANEERDTYSVLVLGTSMLVPRTYDPDTYDFDARMPWTPEPEPYDPETYSAWGRKHFGEEWYQLRKVMLEERNPHDRRDPVYGARQRALRVMEHQAEGRPFKPASGTLHVDETDEGWKRLWARMSNNELGLPRSPSPPPAPPTPPAPPTPSPPSDSSGSREPTPIPTNQWEYVEYMRTHDDLTEEDYHFHRFFVREEIIDRARSRRENEPGNRQAREKRELMESFRQWDLDRFHLEEDNIRDHINLPKKGWTQAEIVAVYEADVAFLEWSRGNPVPREFGYFSKDVSPEEEAASASYSQHDAWNCFYGSQPPKLPPDTHLGVWNLGVWDLWRKGTYGRISRRRRREALLSDAKRDAASCAEELERIEGEEQRDREALERASKRSTELTQKADRTTHLLSPQDRAEWTRRRCMSNLTGFGLIPTYLAHKYGSFPRVKGTELTPQPPAKVPKAGGTGDAPGAHTREAVAHSSATKPQPARGTLRKTCSGRITKNTLTQAEASTRAASQRHSRQRKTYKKERASRRLAKLEPEYGMLDNARRK</sequence>
</entry>
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    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="35407818"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14367"/>
    <dbReference type="HOGENOM" id="CLU_619705_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="49786" checksum="92D809FD7ACF20D3" modified="2013-09-18" version="1">MFSLVAVPELWDIIAQCLAPTDLLHLSSVSRAFNAITEKHLYRKIIWTWDHSKPDASMPIQQLLLNLLHRPELASFIREFSVQEIGYGPKPRMHADSNSLRDADVAISSLIQEAGLSPSEDWLKRLYGLEVEIIVALVILQLRNVEILVIDMFHRDDGYGSPIPNFSPIGDVLRLACNPHSMTRATKLERLEAFSWPSGDFDCHTDLMRRGEVLDMLPIFRASRLREVALKLSCPEPPLDAAMPTVSPSESLTSLTLRYTTVAESFLKQLLSQMKNLEFFRLDLYRSGEAHIFDGQSISQGLMPCRKVLRDLTIHWEACDDYIEVDVPSSTPLGSLKGFSALESIDATSTAVIDDDLTLGDVLPPTLKALVLRQGLDDFNVSWEEGFSSILEEFANLSPVPTPCLTELRIGVWQLLEGERAEQDLREKYHQNHGVEVSFFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023577380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA28"/>
    <dbReference type="STRING" id="1279085.S0EA28"/>
    <dbReference type="GeneID" id="35400636"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07159"/>
    <dbReference type="HOGENOM" id="CLU_030057_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="353" mass="39152" checksum="C8CA8CB178D6ABEE" modified="2013-09-18" version="1">MDNDNWKEGHTRVAGQKRFKSTANVRIVERLKHITWAWFTFVMSTGGIALLLHSTPHQFRGLQVIGKIYFILTLVLFVAIVSGLVFRFMKTPYALRSSLMHPTESLFFPCSLLSVATIIANATVYGVPATGPWLATALRVCFWLYAGLSILSAIVQFYVLFTGAHLPIHSMTPAWILPVFPAMLTGTLASALMSSQSPEHRMSMIVAGLTFQGLGWTVSLFMYPLYLGRLMQDGLPAPAMRPGMFIAVGPAGYTAVAIIGMSRSLPEGYGYFATYPMANEILRVLALWTGVWIWCVGFWFLGFSLFAVLASALRWKLKFSMSWWAFVFPNIGFTLATAYIGEELQSEGINGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA60</accession>
    <name>S0EA60_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433880.1">
        <property type="nucleotide sequence ID" value="XM_023581246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA60"/>
    <dbReference type="STRING" id="1279085.S0EA60"/>
    <dbReference type="GeneID" id="35401569"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08092"/>
    <dbReference type="HOGENOM" id="CLU_628575_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.50">
        <property type="entry name" value="putative glycoside hydrolase family protein from bacillus halodurans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF0">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="2">
        <location>
            <begin position="181"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="436" mass="48533" checksum="C2B47232645F417A" modified="2013-09-18" version="1">MARKLLTENDYTGAAGLASDMYGIPPQNRWYSVTGNLLLDFGPQTEEVSNYERWLDTLEGTTGISYDIMESHTPNFPLGVIAARFTASKHGSLNIGVSLERDRGIITSTVDLFLDVETSFQWKSESDWKAGLVNKLDQAVKRGFESLKVEATSDHQSLMERVALDLGSNKGTLSQPTDKRGSKFTVNINTEMNYWLAETTDLTETLRPLWDLMYRSRDKGSEVATKMYSYPGYVSHHNLDLWGDSAPHDSGTAYSIWPSSNLKAFLREKAWPLFKDIAAFFDCCLFEFDGKWTSGPSTSPENVFIIPKDGSKAGSKESFDISITMDNSLLHEFFSNVIEAAGILGVDLSTDKVLSKVKTYRDGLRPTEIGARGQIPEWRQDYTEAEPGHRHYSRLVDLFPAKAISPLLNKTLANAAQKTIEPRLHAGGASTGWSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAM3</accession>
    <name>S0EAM3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432886.1">
        <property type="nucleotide sequence ID" value="XM_023579245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAM3"/>
    <dbReference type="GeneID" id="35399450"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05972"/>
    <dbReference type="HOGENOM" id="CLU_581468_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="470" mass="52082" checksum="73C51C6011B6F888" modified="2013-09-18" version="1">MAICIDCPIDEREAGSGRQQKHFNQGFDSRLARDIRCIPYAMHYSRDGAKFAAIKATDNSRLWVDRFGTGEECLMTTYRCGGPVPSKRNSRLQLVIEYTSVCNNKPRLLFLHQADVGTAPHALVPTLDCISDLPRYLLTNIVATFPFPELTNKPHHATEAVTVTPGEGQIYPACPICVSIVKYEPDTEHTLSAIPPQLNVTALSQNTNTVKTHDSGKQKMVMDQYGIVHQQLHVPVTLQVHELFTVSGSPASTGSQNQTPLTVQQVSRPKWHGPTKAVLATLLRSDFLKWVVQIDRSPSWRIADNRLGSRFRLGIHELNEASVRFQNDKMLTTSFVPTWICLVSSHPGQSLVPCAGPRSTSLRHAYTKTNFLGTSSHTLQLKHNRHPSASCTLFHLDLWLSGSTLAGLVVVIQVDVRDPLRTASVAMPDLIVSLSSRSGVVAEYWFSLRAREENFNMLVPDSLAESGAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB02</accession>
    <name>S0EB02_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable maltose permease (MalP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_05534</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431713.1">
        <property type="nucleotide sequence ID" value="XM_023578755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB02"/>
    <dbReference type="GeneID" id="35399013"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05534"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="63"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT69633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="557" mass="62112" checksum="4C5FD89F31810F18" modified="2013-09-18" version="1">MAYNNGPDEKGDRRESVAAQHIHEVNDSEELRGILTAAENAAAAEHNMTFMEGLRAYPKAMGWSIALSTCIIMEGYDTILIGNLYAMKPFNEYYGHPDGKGGYSISAAWQSGLTNGASVGEILGLYVSGWLADRYGYKKVLATALVMMTAFIFIQFFSVSLSMLLAGEILCGLPWGVFQTLTTTYAAEVCPIHLRCYLTTYVNLCWVIGQLIASGVLRGVITLDSKWSYKIPFAVQWVWPIPILIAVLLAPESPWWFIRKGRVEDAKRSVERLQRKGTGVNADDTVAMMVHTDKVEKKISEGTGYLDCFRGRVNLRRTEIACLTWICQTICGSSFMGNSTYFYEQAGLAESNAFTMTIAQFALGFVGTVLSWPLMARVGRRTIYVWGLFALTVILFVTGCLGIPAKAPSYSWAIGSLLLVYTFTYDITVGPVCYSLVAELPSSRLRQRTIVLARNAYNIVGVAYTNIIGLYSLNPTAWNWGAKSAFFWAGNCALCFLWAYFRLPEPKDRSYAELDMLFDQGVSARKFATTYVNPYEVTERRFDQDADIKEKSMSHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB42</accession>
    <name>S0EB42_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to cytochrome P450 monooxygenase (LovA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_13863</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Plant hormone biosynthesis; gibberellin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434214.1">
        <property type="nucleotide sequence ID" value="XM_023581529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB42"/>
    <dbReference type="STRING" id="1279085.S0EB42"/>
    <dbReference type="GeneID" id="35407317"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13863"/>
    <dbReference type="HOGENOM" id="CLU_022195_9_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485063" evidence="12">
        <location>
            <begin position="20"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT72136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="513" mass="58121" checksum="F01E251B82D57A41" modified="2013-09-18" version="1">MSFYLFVAVFLAIVYLAQYRSSPRLPSSLPRLKRDSYLPFKLQWAYLTDCRQLFLEAYGTFTKHGKACVLPSMGFKDEVHLAHHHTQWAASQPDAVLSPIEGFREIDKGDWNSGHASYIQDPWQSIVIKKEMGRFLEILAAAVDDELQYAIPEYIKPGASDEVDVYEAMKWIVAQVSSRFTVGLPLCRDKEYLKDSLAFADLFILNSGLLIYTPSLLKPLIGFLVTLPTRYRRWKIQRHIQPLYEERTKRLLNPGLCEKSEEPTDNLQMMMRYATSKHGSQVSPSQISDRLCLANLASFHQTAVAISNALINIAASDAEFNTIAVIRKEIADVLAESNGVFDKSSVSKMIQTDSILRESMRTHGFGNRAMIRKIVVPGGLKTPDGHTLPNGSTLSILSYPVHQDPDIYENPDKFYPFRFSNMRTGPDGKDANPTLSFVSTSSTYLPFGHGKHACPGRFLVDFEMKMILYHVLNRFDIELLPEHNGVRPESQWVTEAVMPPVSVKLRFRKRGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBG9</accession>
    <name>S0EBG9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to magnesium dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433171.1">
        <property type="nucleotide sequence ID" value="XM_023580389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBG9"/>
    <dbReference type="STRING" id="1279085.S0EBG9"/>
    <dbReference type="GeneID" id="35402338"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08863"/>
    <dbReference type="HOGENOM" id="CLU_071162_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000155">
        <property type="entry name" value="Putative magnesium dependent phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="222" mass="24613" checksum="9646D7C2EA178FBC" modified="2013-09-18" version="1">MPKKLSKNPLPPSTSTLSTISTASTSSTALPSSLADPSLPLPKLIVFDLDYTLWPFWVDTHVTPPLKPNSSHTSATDRYGEDYGFFSDVPAILHALPRAGIKIGVASRTSAPSLARDLLKMLHITGPEGGKPKKALDVFEGLLEIYPGCKIKHFESLQKRTGIKYEDMLFFDDEPRNRDTESLGVTMCLVRDGVTWGELERGVTQWRNRRGYITRPEVPEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC08</accession>
    <name>S0EC08_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433416.1">
        <property type="nucleotide sequence ID" value="XM_023580678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC08"/>
    <dbReference type="STRING" id="1279085.S0EC08"/>
    <dbReference type="GeneID" id="35402078"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08602"/>
    <dbReference type="HOGENOM" id="CLU_083918_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="CDD" id="cd00457">
        <property type="entry name" value="PEBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049556">
        <property type="entry name" value="PhiB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="200" mass="22354" checksum="2E84531B9E55249B" modified="2013-09-18" version="1">MTAYIELAASWLFKNSKGRDAKAFFTTPAFAEHPDPTLAVTSPDCGPDGATSGKDYMHGGQHKFPELSWDSHSGVREWLIVSEDPDAPLPTPICHGIYLGIPSEKTRVVGSDFESVEKSSNRLAGGFYYGASRNGSVYIAPRPLLNHGIHRYWYEVIGLNEPLDEKFKISKPNRDQVAEAINGKIVVWGRWMGQCERRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC32</accession>
    <name>S0EC32_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to RNA binding protein Nrd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_08575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433441.1">
        <property type="nucleotide sequence ID" value="XM_023580708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC32"/>
    <dbReference type="SMR" id="S0EC32"/>
    <dbReference type="STRING" id="1279085.S0EC32"/>
    <dbReference type="GeneID" id="35402051"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08575"/>
    <dbReference type="HOGENOM" id="CLU_017390_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12520">
        <property type="entry name" value="RRM1_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12521">
        <property type="entry name" value="RRM3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12522">
        <property type="entry name" value="RRM4_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000047">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000130">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034195">
        <property type="entry name" value="Mrn1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018835">
        <property type="entry name" value="RNA-binding_domain_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10378">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="194"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="285"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="419"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="510"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="577"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="586"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT71362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="786" mass="83656" checksum="6CF102001158A6A1" modified="2013-09-18" version="1">MQDLNGPVGQGAPNGPANRFGHASKPSNSDTGFSHGAFNSNISGFADRHPRRGNIPSINTQPQPMVQQASNNGVDMATPGTAFDMQFTPLLPSQLLLGSPFQPGTPAAFASPQFQSIPGFQQQQGNNQPQNGISSPVQQTISPQSYQGIVSPSTYGAPQFYPPQSPTGGFGMQAPLPPTSPVSMGSGVVTGTSRTVYLGNIPPDTVAEEILGHVRSGQIESVRLLPDKNCAFISFLDASSATHFHSDAILKKLCIKGQDIKIGWGKPSQVPTSVALAVQQSGASRNVYLGNLPEEVSEEELREDLGKFGAIDTIKIVREKNIAFVHYLSIANAIKAVSQLPQEPKWQAPRRVYYGKDRCAYVSKTQQQNAAQYLGIAPGYAHMLTGADRDLISNALAQQSVAAAAVATTAGGINNLGNRTIYLGNIHPETTIEEICNVVRGGLLHHIRYIPDKHICFVTFIDPTAAASFYALSNIQGLMIHNRRLKIGWGKHSGALPPAIALAVSGGASRNVYIGNLDETWTEERLRQDFSEYGEIELVNTLREKSCAFVNFTNIANAIKAIEAIRGRDDYRKFKVNFGKDRCGNPPRQMQQSQSPRGDGVSSPPPNGSQNSGSPTNGNTPQQSAALFNANSNPLTMYLNQVSHQAQQQQHHQQQQIVAQQNALFGTAQPSPSDLDLAMSQQVPVSGHGQSASISNGYPANSAAPGATTIGGLLAPGRGQHSRAVSLPVLAPGFENGGNASNGIPGAETEQRRGHHYQASYGGMGSGFGLAIQGGLNGWVEEEVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC47</accession>
    <name>S0EC47_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to 2`-hydroxyisoflavone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434532.1">
        <property type="nucleotide sequence ID" value="XM_023581923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC47"/>
    <dbReference type="GeneID" id="35405785"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12329"/>
    <dbReference type="HOGENOM" id="CLU_044876_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="327" mass="36502" checksum="82D1A733F767A18D" modified="2013-09-18" version="1">MVKIAIAGGAGNVGQEVVDALVARNKHEIIILSRKDAPETEIAPGVKWFKTKYDNVEELTNILEGVHTVLSFMSVAPGDTAAGPQEKLIDAAVRAGVKRFAPSEWASSNLDYFPWYDFKRSAREYLAELNKDKKVIEYTLFQFGLFTNYMTYPYKSSKHVNLFETPVNFHDRRALLIDDGEAVITLTTAQDAAKVTALAVEYEGEWPVVSGVNGTDITMNELVALGEKIRGQKFKVEYLKGQDLEAGIVKASWLPLPEHPSIPVEMREKIAADMIKCFLLGIKHGALKVSDEWNRLLPEYEFTQPEKFLTKAWAAIDVGAKSVFTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECR2</accession>
    <name>S0ECR2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_08313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433676.1">
        <property type="nucleotide sequence ID" value="XM_023581000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECR2"/>
    <dbReference type="STRING" id="1279085.S0ECR2"/>
    <dbReference type="GeneID" id="35401789"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08313"/>
    <dbReference type="HOGENOM" id="CLU_069054_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="125"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT71597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="245" mass="27237" checksum="C7065AAF3B1307E7" modified="2013-09-18" version="1">MFASRSITRIALRRGCPLRQFSTSRPLAVSYHSYTLPTHTSTPPRNDDVPETSITQPDPLPKVHETRPPPQQPQHPQPPKQQEPAPTHNATPATSASAPKLSETEAQKPKAARPRPKLRPRKAAMKLTPSAVEQLRELLDQPEPKLIKVGVRNRGCSGLAYHLEYVDKPGAFDETVEQDGVKVLIDSKALFSIIGSEMDYVEDKLNQRFVFKNPNISKLPQEPQTGIVLTDFSEEECGCGESFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDU7</accession>
    <name>S0EDU7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_06538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432637.1">
        <property type="nucleotide sequence ID" value="XM_023579874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDU7"/>
    <dbReference type="STRING" id="1279085.S0EDU7"/>
    <dbReference type="GeneID" id="35400015"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06538"/>
    <dbReference type="HOGENOM" id="CLU_016834_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495816" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="22"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="417"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="150"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT70558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="566" mass="62916" checksum="9A672403CB675B2E" modified="2013-09-18" version="1">MQHPNSLALLGAIYAFTLAAAGSVPRGVGPEFASHYQGDEFSCITNAAIKLSLDRVNDNTCDCPDGSDEPGTAACANLDPLSPEQPLAGSVSGTTNTTNALPGFWCENKGHIGMYVPFLYVNDGVCDYELCCDGSEEYAGVGGVKCENKCAEIGKEYRRLEDEKKKALQKAAMKRGAMVSEAKNLRQKVEKKVEDLKKEIAALEVKKEELAQKHRDAEQQDKGKVVREGPGSGKLGVLVGLAKTRVNELRDTLDRVVTQRDALKERVGELEELLTKFKTDYNPNFNDEGVKAAIRSFEDYSARRAESKEEVVNDEDVLSVLKEDGENSGVNWSEFEEGEGSDTDILYNFEAYLPPPVRAFIHNSLDNLRVWAITNGILADNSSPGKESTLVRTAREAVDAAKRDLSDKKSSLDVEQADLDFDYGPDDIFRALKDKCVTLEAGEYTYEQCWLGSTKQKSKKGHGQSNMGNFKRIDREMADEEDRIDGKSLGRGERMVLRYEDGQQCWNGPQRRTDVWLGCAETEELWRVSESEKCVYRMEIGTPAACDFSRWDVGSQPKKPRSRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDX2</accession>
    <name>S0EDX2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DAL1-Allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="2">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435117.1">
        <property type="nucleotide sequence ID" value="XM_023567795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDX2"/>
    <dbReference type="STRING" id="1279085.S0EDX2"/>
    <dbReference type="GeneID" id="35406395"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12939"/>
    <dbReference type="HOGENOM" id="CLU_015572_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF96">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="56"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="309"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="496" mass="54246" checksum="6EF7DA328CB1305C" modified="2013-09-18" version="1">MVEPFDLVITHGVCVTASDVGAYDVAIKDGKIALLAASGSLAQTETLQLIDAEGAYVTPGGVDCHVHLQEPAMFGNGSSSDTFETGTRSAIAGGSTTIVCFAPQQRHEPSLLKPLADAHNKARGNTYCDYGFHLLVSNPTETALSELGMLKAEGVTSLKIYMTYEALQLRDDQILSVLHHARNNHILTMIHAENGDILNWLTSQLEANKLFAPKYHATSRPPALEAEATNRAIVLSSLIANTPILLVHISDPGAAYRIRQAQTAGQPVFAETCPQYLFLTRDDLDAPGFEGAKFVCSPPPRDEASQDVIWEGLRNGTFTLLSSDHCPFSYDDIEKGKKACITPEHPVGEFRHIPNGIPGVETRLPLVFSANRLPLTKFVEVTSTNAAKLYGLYPKKGAIIPGLSDADLVIWYPNDKLPDVTIRNEMLHHANDYTPYEGKTARNWPRYTILRGMVVWDNGKIVGKKGYGEFVQRQAGVLNDVWECVQEQGQFSVAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE74</accession>
    <name>S0EE74_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435187.1">
        <property type="nucleotide sequence ID" value="XM_023582379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EE74"/>
    <dbReference type="STRING" id="1279085.S0EE74"/>
    <dbReference type="GeneID" id="35406194"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12738"/>
    <dbReference type="HOGENOM" id="CLU_1384272_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="197" mass="22065" checksum="504BEF49F24FD9DD" modified="2013-09-18" version="1">MAMATTLTRVFEGSSLDDWIRVYHNTKNKNAYWFRQNLGGGKFDQSVQFNVDMNCDLDHWYALADFLGQNSDGLDDFFCIKENAVWLSLNRGGKPLQFSTTSVRITLEAMEEQIFVESSYGKIACVHPEANEPGLAVIGALDRGWGDKSQWQGFSTAQGIRGTVFSTVQPEKPGITLGMTYLKFRLLRRIGSVMSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE79</accession>
    <name>S0EE79_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435334.1">
        <property type="nucleotide sequence ID" value="XM_023567966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EE79"/>
    <dbReference type="STRING" id="1279085.S0EE79"/>
    <dbReference type="GeneID" id="35403529"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10062"/>
    <dbReference type="HOGENOM" id="CLU_039184_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18056" checksum="DCC3104C0C500567" modified="2013-09-18" version="1">MYIVFRYLLHSTKTPVQVWPDLREAHDATCNKGISRKELADKFPNLDFSACPEKWDFPPHTPDDATVRAERVRRRLKDVARTGGYKNIMLVTHRGIAAFLVQGDRFSVCEHRSYRFATSEEVDNARHGVNVDTGLEQDFGPTVLIPAEKPKTRQDKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEM2</accession>
    <name>S0EEM2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434400.1">
        <property type="nucleotide sequence ID" value="XM_023581751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEM2"/>
    <dbReference type="GeneID" id="35405632"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12176"/>
    <dbReference type="HOGENOM" id="CLU_024652_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="587" mass="65587" checksum="2E07EE719DF5ED6D" modified="2013-09-18" version="1">MFDVIWVDPDRELVGEHRAKKEIKRELKNKEREKEQENSILSRSISVTSTRSSTESRFGFLRTRNGKHAKGKEKTPSGLLTPSHHSSRSNSGSYHRSALMANLSNVSLGVERALRANTPVSTDASSSHVAKRNEVSQSRPSDLENPDLCSEVHGYSELEGDHPPTPAGSMGDRNFPVPILQSESPNSLVPSLNLPKEPKAPIVINFRPNDPDSWRPPEEWEYIDRQAEEEARMLENQEDVEMTVDAEETAQVKPCTDFESIKDQVKAMAASSPSMILARIKEIWTVTDERLHGELNIELKRWMLSVLNYLDIEARDGAGVACVVANTSDDLGVLALYESEITATYLAALRSTREVFSLTTASFQNKELPNIHPVLVPSMTPSTLPISQHSFAIVYSLSLPAVCSSPEIPGVLKNISNRLRVGGSLQLTLIDPLPCASTLGHRMRAWLQEHLLINLERHFKCTNPSRLFPEWMGDAGLRGQGSTLTTSKFYAVSASIRSQADDSDPFVDRIPSEREVKAEVRSIIGRLLWMEVWGSFVTGDKWWWEDEGCVNECLQLGTVWEYHMIDGVKQGQEDIPEGVEGLENLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFD2</accession>
    <name>S0EFD2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
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            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="35403367"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09900"/>
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        <property type="component" value="Chromosome IX"/>
    </dbReference>
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        <property type="entry name" value="Pan_app"/>
    </dbReference>
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        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495923" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="333"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="766"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="706"/>
            <end position="752"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="53"/>
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            <end position="275"/>
        </location>
    </feature>
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            <begin position="276"/>
            <end position="318"/>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="734"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="849" mass="88557" checksum="61F5978CBDD77970" modified="2013-09-18" version="1">MRSVSALVALAFASSLELVAASNCKPSSPVGVKTTDSASITSGTSTKSAPPSETTDEPVIITNEVTNGDFGGYDPSSDGGIYAFQAGGDAKLLQGPGYQGDHTEETNCVQLKTNSGNPGQKRDFISDNPYIQQQLDNLEPSDFTVRFWYSIVNNAIADTCRIEGLYGNAQFGATPYFPVVSEGNSWLEFVDSMPVTTSSGMIRFELNCINGGSAEVYFDQVFVSNKIGDEWVDGISLFFPTSKHAATIAPAQTSTAPAVDTATASSDNTESSGPPTTQASQAQTTTDEASSTDKTIESTSASASAPTSAPTDPTTSGPKLCAKLGTGAAGRGCAKRPYSSTKGYKGYGGSKITKEQCASLCLADTNCQSFEWRYFGSGCANTCNLLATNWADIPTNGGSDSAWAYDRSCIQEDECAEQPAGSVCVNVNADTPAKSCTQVKGKAKACAKPFLTAQTNGVCGLSNECRDLCAKYPSCKSYAATFGSCSLYDARSSEVAEAGSELFWFTDMDCHSCGQGNAYFDYISVSQDPANMPQWTCAAEDKTSSTLAAPTTTNPAITTTSGAEAATSTSQASDEADSSTIIPTTTSTSPSTTASLCANGVPSPGICSAANVVPSTATCGKRGWPRNVEPYGRSLADFPNQNTFEDCALICKLDRSCKAFAIDPTRSGMKCMFSSDPTIYGVSNAPGVWSDLECMSCMLCDDSVTSSQPVSEAPTTMITSTRPAGEDSSSQAATSASGEPTTTQTTQAEPTDCAVPSASLSGDVTCGIPGQSGQQAQSARLLNYVIKPVGNLANCAAVCLQRSDCQGFAYIKSNTECYPFRVGSAGLGITYNPQGTEKYYDRGCFSCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFE2</accession>
    <name>S0EFE2_GIBF5</name>
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        <submittedName>
            <fullName evidence="3">Related to atrophin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023568264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFE2"/>
    <dbReference type="STRING" id="1279085.S0EFE2"/>
    <dbReference type="GeneID" id="35403262"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09795"/>
    <dbReference type="HOGENOM" id="CLU_015359_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
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        <property type="entry name" value="Fluconazole_resistance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065:SF1">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065">
        <property type="entry name" value="FREQUENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="327"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
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        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
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        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="594" mass="64284" checksum="3EBC19308CA357F4" modified="2013-09-18" version="1">MSPSPLKTPGPGPESGSGAGSEQASCVGSDRHQSSTGTTAAPTESSNVDIGSVAKTSDPDQGQEQEHQHSRQQSPARDITPSSPTNIHPLLQVASAPPHSRSTIAATDTTPATTTPITESPALPLGSPKQSPANTAQLASRATEARASTSSNMIFSDIYKSPRSPIAKLRHHSVQLPTPLPTNTPDWYGEEHADLLSKDKVKQKEAVKRYLDAKVKNDWEFPWPSRVVEPPLLEGDVAVVDTASETPDAIEAVTSLDVTEPTKSIQDKTREDDGYQIDEPESSDNEDGSDAESTYSTVSEDLVNFRTRLDWASDLSDDEDEPGPSRSPFRFDNPNNVGSTVQAVVQGKRAKRRRAVRKEMEWNEGLACFEARRNAWTGARTVRVRAKPATPPAVSPLSPRRFFFRRSMSTSPPASTIASTLPPQVSDASDNSSLTRSDELRNARSKDTTPSTPPDSRNYPVEVLLPLPPPLLPPNNPLRASITPSVYLSLYDKVIIHSLQPSCPINLSDMLRACVTGWKRDGEWPPRPTMAPAPVAKKKKPKKPSNPSENAGSTVRRMSFGLLGRDKDDSTSGKGIRRSLVRALGIGEGTETPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFL3</accession>
    <name>S0EFL3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to myosin tail region-interacting protein MTI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
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            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023580482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFL3"/>
    <dbReference type="STRING" id="1279085.S0EFL3"/>
    <dbReference type="GeneID" id="35402254"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08778"/>
    <dbReference type="HOGENOM" id="CLU_003021_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="CDD" id="cd11887">
        <property type="entry name" value="SH3_Bbc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035552">
        <property type="entry name" value="Mti1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF6">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G10320)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="596"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="751"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1215" mass="131310" checksum="4DEA8F8D9C29873C" modified="2013-09-18" version="1">MAAPFRVKAIYEYSSPHEDDLNFSIGQVITVTDEEDADWYGGEYVDDHGVKQEGIFPRNFVEKFEPTAPPRPARTRTKKEPEPAQPAEDIASPPPPPVQQEAPSIPAPEPEPEIEEAHEPIHKQSAPEPAAPAIPEPVTSKPAEPVQATAPPPVAVPKPEPPAPAPQAPVAASPKPKPSGPPPKAEKPPASSFKDRIAAFNKPAAPPVAPFKPSGLAGSGTGFIKKPFVAPPPSRNAFIPPPQQTPTAKVYRRDEDPEIKEREAETQGQAERAGLVPSEGQGGEDEDQPKPTSLKERIALLQKQQQEQAARHADLAAKKEKPKKPHKKRESVGHIDTPVEAEASPQEPHAPLERRDTQDTEVRTSMDEPRQNRMPPPPRRRSSKGPAVEPVHDGNEADMSGAGDTTEGNDDLAERDDSDGVARNAPRAPALPIHAGPPPEAPTSRKEDSEEADEEEEEEEEMDPEVRRKEELRARMAKMSGGMGFHGMFGAPMPAPAPPPKKKKAPKPERTSIDETVEDASPTSHAAPPVPTMMALPGFGGSSKPEEPSRPEEHEPAARAPPPPVPSQPPRVPEHAEMAEEEAEGDITPAPHTAPTVPPRDPAGPPPIPGSRGVPPPVPSESRPPPAPPADVKSQSEGSQSGDELSGGRDSDREGSVAAARSPPMAPPPVQPPHLPARSPPLSPTREEFSPTSPKPNASNRLSRLPPPIPGSAPALPAQSRPPPPPPPGGLRRQSTQDSHAQHTRGPPQAGEEEAEELTEYEGDYDTDIASSVPHKDALKSHARESSLEDNSILSPVSDAPPKLPPPIPTGTAPRAVPPPVPSQPPPENMRQSIDTPRAAPPPPPPTDNKRQSIDVPRAGLLPPQPPQSPRLEEDYDPYNYSAPPGGHGYAPRTPKIEEEGIFPQSPSVTSPIDRRPPPPPGVPAGRTSGRQSLDISRAAAGNRRSMDVHRPSMSMESGFIANDLDLAIQSGWWKQSNQVPPVLQGRKDIYFEAEESTSTNGGQQTTITREIFILYQDYSQTFLTIRYDPYDASDVQLEQRHEPPPRPLRQDQMEEFYERFGRHISTAAAAKKDSVVADGTPQGLVLELLKPYKDALPPVGTRAYGALVYSNMANASTQQNDVIRAGDIITIRNAKFQGKHGPMHAKYSAEVGKPDHVAVVSEWDGTKKKVRAWEQGRESKKVKVESFKLDDLRSGEVKIWRVMPRSWVGWNSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EG25</accession>
    <name>S0EG25_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435678.1">
        <property type="nucleotide sequence ID" value="XM_023568484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EG25"/>
    <dbReference type="STRING" id="1279085.S0EG25"/>
    <dbReference type="GeneID" id="35403063"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09595"/>
    <dbReference type="HOGENOM" id="CLU_074390_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24490" checksum="0B3CCD968A301828" modified="2013-09-18" version="1">MASRSLIRPCSAQRAVCQALVQTQRPRSATTVFRAATSTVSPRSQASTSSRRLFHALPSRRKDQQPPAQPPPTDFAELDVLGNTPAPSTSVDVCMYDGFGLNSGITVTGGNGVLLIDGEVFNWRPWEAKGSMNLVNKKGQFELPPKAFALFDLLWPRPDLLIIGVGPSIMPLAPETRRLISELGMRIEILDTRNAAAQFNLLATERGVSNVAAALIPIGWKDGVGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGB7</accession>
    <name>S0EGB7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to fzr protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433522.1">
        <property type="nucleotide sequence ID" value="XM_023580812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGB7"/>
    <dbReference type="STRING" id="1279085.S0EGB7"/>
    <dbReference type="GeneID" id="35401958"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08482"/>
    <dbReference type="HOGENOM" id="CLU_014831_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="758" mass="83779" checksum="1D133CCDD5B1BEE3" modified="2013-09-18" version="1">MFRQPPRRPRLLPRTSGADLSCQSINSPDSGYSSADEVFGLCLNLRKRCFPSFDGPGPDEIPVKSLENQEQKPPASSKTGLAAEPPKTPERRHPKGKADVISPFLYSKSSRRFPLQDKRIDPNIQYLDRYVPRRDPISQSSERYRTTKQSQDLSRDERLRRDKSASADPFVLKRRVMDPDPRFPFRVDDSHLDRGIALGQLPQNRGGDRQVSMGAMWSVGGLAPNAIATDDGQGHLVRRGTNARVFPTLFQESLVSTSVEKEKHEGRIASALDIDQVRKILEFARAQQIPRSIKQHGLHADFSHTSWNGHQWANKEQWSIPLRPAKRRLLPATPFRVLDAPNLKDDFYCSPLAYSYTAQTLVLTSVAFSSTPGGKAVLGIGHSDGSVLFQSLFDPLPRFEIRQAFPISCVSWRPVCTLRPSKNPMNLGVEVLTEDLVVGDEMGNIYYYVVEWPIGWEVTRDTWPGAVLLVTKISNIHCQQVCGLAWSYDGRLFASGGNDNLCCLFDADQVSGRRTEQAPGVNGVRGRIEAGSAYGGIETRVTRLLSVDGDDDMPARAFRAQLQPLPSGTDTVRYLGPAIAKHHWNHDAAVKAIAFCPWRRELVATGGGSNDKCIHFFHTPSGAALATISVSAQVTSLIWNTTRREIAATFGYASPEHPYRVSVFSWPECKQVAAIPWEDDLRALYAISYPRGPTSDDPTAPAGGKEGCIVVASSDKSIKFHEVWSRERGVTVGATGILAGSDILEGLEGIDKEGDVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGE8</accession>
    <name>S0EGE8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433542.1">
        <property type="nucleotide sequence ID" value="XM_023580838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGE8"/>
    <dbReference type="STRING" id="1279085.S0EGE8"/>
    <dbReference type="GeneID" id="35401935"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08459"/>
    <dbReference type="HOGENOM" id="CLU_032510_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="524" mass="59193" checksum="1292DBCD5C9BD186" modified="2013-09-18" version="1">MFQARWKSPAELDHQLPSRRDSQDSVMGRLGGKNVVIFCSTRVWRGAPKLILQIAALFFTTFLIFGVLPNRLSGGQLRNGSTGLFSWGRHEPEPESNLRIVVFGSPDVVGNVKDPRYRTWTEELCDELNCSSYLSLVPDGRPNRGLISNELHQKGVKDLLNITKHTDVKKKPAFDYNFISKQYPTPDKVPDLASQVKTFLAMPPPEIPPRETLWIFSFGTWEVWNMAAMPRTKSEDIITDMARVILDQAEILYERSLDPTSIAYSDFWTNATETQIRELTAPGALDSVDKRKFESFRIIAPMIFDLSLTPAWQARQAPPVPNSVVEHTRNAAELTKYWNQEVDFAVAEWIERSTKKPQKPASEEKAASKTKTKRTESVEPVEHSEDIKDSAKKTYEDERVIQAPYPMRNGLAVDIGKVLLDAMTEGEMQHAAVVDLRGRGTMSPNATMRFADVWTSCVKADMSDLTIDQDEVTADCAVENDHLFYDSLTISERAMKGAVQAVVQEIKDELFNAQKKKGWLYGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHE7</accession>
    <name>S0EHE7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to reductases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436287.1">
        <property type="nucleotide sequence ID" value="XM_023569013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHE7"/>
    <dbReference type="STRING" id="1279085.S0EHE7"/>
    <dbReference type="GeneID" id="35403716"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10251"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="312" mass="34321" checksum="6E69420373615E89" modified="2013-09-18" version="1">MTFTPQSLPDLSGQVYIVTGGNAGIGFNTVLELAAHKAKVYMGARSEAKANAAIVEIKGQHPQADISVLVMDMMNLKTVKAAADEKESRLHGLVNNAGIMATPYEESVDNYEAQFQTNYLSHWLLTYSLLPILTESARLTRPGTVRVVNVSSDGHLLFSPSAGIDFDDINQTKGTAFSRYGMSKLANILHAKELHRRYGPSPDNDRQEEIWTASLHPGTIDTGLGRNATGSWAWQVLVPVMRLLRLYSPLETAAYTSLFAIAGPDFHQDMSGEYLKPVGIIGKTSSTGQDPKLAEELWHWTEIEMRIKGFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHR5</accession>
    <name>S0EHR5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to alkaline protease (Oryzin)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_10237</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436273.1">
        <property type="nucleotide sequence ID" value="XM_023568998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHR5"/>
    <dbReference type="STRING" id="1279085.S0EHR5"/>
    <dbReference type="GeneID" id="35403702"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10237"/>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485638" evidence="8">
        <location>
            <begin position="18"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="145"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT74195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="394" mass="41115" checksum="7936527A3D4E1E4E" modified="2013-09-18" version="1">MLYKTVVSFGLATIALALPTDRDNKGPGSSNFIVALKPTANADLDLHARWVSDVHGQALARRGVESSGIDKTFSFPGFKGYSGSFDEDTIQIIKANSSVLHVEPEQTFTIASPVTQQSPPWGLSAISNANPPSSKASYTYDSTAGAGTFVYVLDSGIYLEHEEFQGRAVFGADTSGVTTKKQHGTLVAAIVNGVTYGVAKKATVVDVQVLGDDGGSSSGVLAGLSWTVNDIVSKNRAGKAVINMSLSGGNSVILNEAVQKAIDAEIPVVAAAGNSNEDASKSSPGNQPNVITVAASNKDYQRWAHSNWGPACDIFAPGEEITSAWPTSASATRVASGTSEASPHVAGVIAYLFALEGSRTPAQIWSRLKELAIKDKITDVKGVPNLLVYTGIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIF5</accession>
    <name>S0EIF5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_09565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435705.1">
        <property type="nucleotide sequence ID" value="XM_023568517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIF5"/>
    <dbReference type="STRING" id="1279085.S0EIF5"/>
    <dbReference type="GeneID" id="35403033"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09565"/>
    <dbReference type="HOGENOM" id="CLU_070147_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="260" mass="28069" checksum="BA309A523814A4DE" modified="2013-09-18" version="1">MSRKGVGLAAFDRSRLTSAQFASHGSSLRANNAQALETQLAVFRSLLQQFANTHARDIRSDPAFRAQFARMCAAIGVDPLASSNSNGSSDGSSIWAQLLGKTVNDFYFELAVRIVEVCGATRAENGGLIGLAELRERVAAGRMDGADPIADDDVRRAVQTLAPLGGAYAVVRVGRKEYVRSVPRELNDDQVSVVEAAQVLGYVSVSMLRDNLGWDKARARTVIDDLVAGGMLWVDKQTKGEWEYWSPGFMAEAATPDQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIH8</accession>
    <name>S0EIH8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435730.1">
        <property type="nucleotide sequence ID" value="XM_023568549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIH8"/>
    <dbReference type="STRING" id="1279085.S0EIH8"/>
    <dbReference type="GeneID" id="35403005"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09537"/>
    <dbReference type="HOGENOM" id="CLU_092121_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485660" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="27421" checksum="A1DF39B6C935A04E" modified="2013-09-18" version="1">MTGQSTRRWLQLSFLLMAGSASAGSLKLSDFESISDKSFPETCVQAYDTPLSQCTPKDFTDGKACSAACKYSVQQAQGFIQASCGDVSASSESLLSRGQKGNLVAVLCRDVDEPQSEPESAPQTQPKQEPEPEKTQPPATTTTSASSTKVLKNVLIETGHSSLDDKSNGSLDGPPLSSVDEDLATKSTVLAIDTDQPTGSLPMPAPPSMMTSVTKPSAASHTAASASKEPTPTPTTAGGSVHGPSFGFMCASLAMSAIMYMVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0EII3</accession>
    <name>S0EII3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">sterol 22-desaturase</fullName>
            <ecNumber evidence="13">1.14.19.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_10640</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5-dehydroepisterol + NADPH + O2 + H(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:33467"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:52972"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:33468"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="13"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436662.1">
        <property type="nucleotide sequence ID" value="XM_023569447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EII3"/>
    <dbReference type="STRING" id="1279085.S0EII3"/>
    <dbReference type="GeneID" id="35404104"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10640"/>
    <dbReference type="HOGENOM" id="CLU_023517_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0349">Heme</keyword>
    <keyword evidence="9 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT74584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="533" mass="59764" checksum="81633D0B4644A7AD" modified="2013-09-18" version="1">MASIISPRDEASVSNASLTLTDISKGNGLLTSYLNGYSNTQILLTILVVLIAYDQCMYLWRKGPIAGPAFKIPFIGPFIRALYPKFDHYLAQWASGPLSCVSVFHKFVVLASDRDIAHKVFKSPTYAKPCIVPMAETLLRPSAWVFLQGKAHTEYRKGLNGLFVNKALSTYLPVQEKVYDDYFGRFVAASAANKGNPMAFMRLFREINCALSCRTFFGDYISQDAVEKIADDFYEVTAALELVNVPLSVYVPFTKCWKGKRTADAVLAEFAKCAAACKANMASGAEPRCIVDQWVLHMMESKKYHERIAAGEEGVEKPRNLIREFTDDEIGQTMFTFLFASQDASSSATTWLFQVLAQRPDVLDRLREENLAARNGNKQQPFELSMLESLPYTNAVIKELLRYRPPVIFVPYEATKSFPVTPKYTVSKGTLIVPTCYPALHDPQAYPNPDTFDPNRWITGDAESKTKNWLVFGAGPHDCLARRYVPLTMAAMIGKASLELDWVHHATSRSEEIRVFATLFPEDECQLVFTSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIU8</accession>
    <name>S0EIU8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436782.1">
        <property type="nucleotide sequence ID" value="XM_023569588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIU8"/>
    <dbReference type="STRING" id="1279085.S0EIU8"/>
    <dbReference type="GeneID" id="35404231"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10767"/>
    <dbReference type="HOGENOM" id="CLU_054623_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="333" mass="38672" checksum="671BE5A48C0C4EC9" modified="2013-09-18" version="1">MLDDTADIATIDAMGTRFRQAFVQALMRVMETDVAEMTFAEIIDGLPTIGSYQDFHWPQDGHPATQHFEVCPGMIEKARQLRSDYPPTRLKFHLPLLRAFEEATIDSRPFHLRLFELLAVSIHQIAVYSYQQGGFNHTHQDYQKWIDSPRDTRRWDGYRHPTAFCHSFYIAVERYPNGDADTVGYWAEAKIFGGVLVFDRGESESECNELYLHARRRVGPFTLFPLTTAQFEGFVDFLLGDTEEPAASRSPLPFRATSENRWRWHNWDTITRYHIFRDKYERTVQPTKPVGGVKSSVDWPEIGDELYLIGAMQDYWDGQPVDKDKVREALEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJC7</accession>
    <name>S0EJC7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_11180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437174.1">
        <property type="nucleotide sequence ID" value="XM_023570049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJC7"/>
    <dbReference type="STRING" id="1279085.S0EJC7"/>
    <dbReference type="GeneID" id="35404644"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11180"/>
    <dbReference type="HOGENOM" id="CLU_029539_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT75096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="627" mass="70245" checksum="DB5AB5E7450405D5" modified="2013-09-18" version="1">MYRPAPPRPKKTRICRSRDGCYTCRRKHRKCDLTKPSCSNCTRNGLDCEGYDLRLTWLPASLGTGHNPQRPKRKTSTEKVISPPSISPNTATSVSYLDEPDRWLDATIDDATTVDDTQLQQLLTHAVNNPQFSRGFLILDHEAYLLSHFNRCVHGQLMHLMGDWLTELLYHPYLQPALIAISASNLFQEYIFRRDPTLASCNIKGRKIDALTQSCYRLAINYYNHAIRTISDTTSNGNKSPQLNLASTLLLVLFESQSGSIHGSFVHMDGADAIVISSLKQLGQTTTGRPLLKSWADMRARKNRQKLAFRPLEVEFSRASDPRHRVLMSHALQFSSFIAPALTNAISMRDRLVLQACAACEGIDESLVLSHFRQWYSHAFDFKYSEELSSEAGCAVTMKELMSGLDATKQALQEWHSSLDESRLPVSQASLPPALDQSFEDRLVLVEDIIPLQFQTPEAAFDYLRYAVSLVITSPQVLGMYVLATRPRAPKTQVPAVIAHLLSVIEGLNSAELIRYDVYDSGPLWVLVTLALCVPESHIVSWILETILPRYEKYAHRGSLLITFINVKDMLLCIQSQLKKGILPLLCSSSSVITEDLISSPIARFGQKFAIVGRNTLGSFSRMVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJE4</accession>
    <name>S0EJE4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable citrate transport protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_12369</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434571.1">
        <property type="nucleotide sequence ID" value="XM_023581967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJE4"/>
    <dbReference type="STRING" id="1279085.S0EJE4"/>
    <dbReference type="GeneID" id="35405825"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12369"/>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000092">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="104"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="201"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT72493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="298" mass="32420" checksum="C59011CA5B6543BC" modified="2013-09-18" version="1">MASTTQTGEKKKQPSPLRSIIAGSTAGAIEIAITYPAEFAKTRSQLNRRLAEGQKLPWPPFGKQWYAGCTTLIIGNAAKAGIRFVAFDQYKALLVDENGNLSGPRTVLAGFGAGVTESLLAVTPTESIKTTLIDDRKSAKPRMRGFLHAVPIIARERGLRGFFQGFVPTTARQAANSATRFTAYNFFKQMAESYTAPGEKLGAVGTFAIGGLAGLITVYVTQPLDTIKTRMQSIEAKKTYGNSFKCATTIFKQEGVLTFWSGALPRLARLVVSGGLVFTAYEQIQVWFNKIDPDEKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKG8</accession>
    <name>S0EKG8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to bifunctional 4-hydroxyphenylacetate degradation enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437163.1">
        <property type="nucleotide sequence ID" value="XM_023570036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKG8"/>
    <dbReference type="STRING" id="1279085.S0EKG8"/>
    <dbReference type="GeneID" id="35404632"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11168"/>
    <dbReference type="HOGENOM" id="CLU_028458_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051121">
        <property type="entry name" value="FAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796:SF4">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="95"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="305" mass="33310" checksum="5A0C89E699747E5E" modified="2013-09-18" version="1">MSPNRVSFGLATIRNADENLEAAVVVKQWVYPLSSLDESFHGRTVFDLLQDWSRACSSLQQFASRVVNGDAQVGRHQIQLKDANFHTPICYPNKLLAVGANYSGHLKEMGLSVEKWNPMPFFSCPPTSTIVGPGKTVPLPPTTKQFDWECELTVVMGKGLRNAAQEQAAEAIAGYTIGLDLSCRDLFQTGPQGLVDIIRGKAQPGMKPCGPVFWPKECIGNLDNVPVKLWLNGDLMMDGSTSEMIRSPAECIAEMSQILPLDPGDMVMTGTPSGSARSHGNRWLVKGDCIKAQIGDMEPLDVEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKJ6</accession>
    <name>S0EKJ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to ECM4 protein (Involved in cell wall biogenesis and architecture)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436500.1">
        <property type="nucleotide sequence ID" value="XM_023569260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKJ6"/>
    <dbReference type="STRING" id="1279085.S0EKJ6"/>
    <dbReference type="GeneID" id="35403937"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10472"/>
    <dbReference type="HOGENOM" id="CLU_037263_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="112"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="4">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="4">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT74422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="346" mass="39920" checksum="0F0BE0505652D3DE" modified="2013-09-18" version="1">MTVHSSPDDSWHGVITSDGPFQPEKDRYHLYIGLFCPFAHRANLVRHLKGLQDIISLSVVKPYPKGDDKGWPGWQFPSPPDDDYEGATEDQLFKSKYMHEVYFRDDPDYKGRYSVPVLWDKKENRMVNNESHELLRWLPTAFDSILDSNSLGRDLDLYPENLRSTIDDINVWMQRDLNSGVYKAGFATTQEDYNNNVPTVFAALNKLEALIHQNGGPYILGKQLTEVDVRAYATVVRFDVVYVGHFKCDLGTIRANYPVTHEWLKNLYWNVPGFKETTDFKHIKENYTKSHYKINPLAITPLGPFPYMEEGVDLDFGKLKPGLIRHPAVLERQKELCGSEDFSQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL71</accession>
    <name>S0EL71_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437428.1">
        <property type="nucleotide sequence ID" value="XM_023570295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL71"/>
    <dbReference type="GeneID" id="35404863"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11401"/>
    <dbReference type="HOGENOM" id="CLU_1686739_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="154" mass="17136" checksum="DE4807B0A963F873" modified="2013-09-18" version="1">MSDRTKIPSSDETNPPHAQLFIAASPTLDFMPKIKVKVPSRWMVAVLIPSTNTWLTAQGRQNEARYTLIKVEAPPEGSKFFEVASIPVSNLGDVEARIRSVLPEENPEGETQFNRQYVRDVLKDLVDGGIIREDQARDALLAVEAFAELSLKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELB9</accession>
    <name>S0ELB9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to pisatin demethylase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_10147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435256.1">
        <property type="nucleotide sequence ID" value="XM_023567873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELB9"/>
    <dbReference type="STRING" id="1279085.S0ELB9"/>
    <dbReference type="GeneID" id="35403613"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10147"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF190">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="478" mass="54075" checksum="06A43AD3833151BB" modified="2013-09-18" version="1">MTDISLLYLILGLILASGLLKIATFVYGYFFSPLKSIPGPFLARFTDAWYLWRLYKGNFERDNVALHREYAIKAIYGLEKAFPKSSWYDAWVAPGEVSLFADRDTKRHAYHRRLFQNNYSMSSLISYEPYVDECADLFVQRLSEISQTGLPLDMGHWLQCYAFDVIGLITYGKRLGFLDSGKDIGGVMEALEAFLSYAAPNYFAGSSGTGRAYVISFTRSRVAESMKTPTAVPAEKKTTSAEPFLLKFLEKHEQSPDKFTSTNVTMGCVANMVAGSDTTGITLSAILYYLLKHPPCLAALQQEIDFYYSEGKLSGKPTFQETQQMPYLQAVIKETLRLHPATGLPLERVVPKGGATISGHFFPEGSIIGINTWVQHRNQSIYGLDADIYRPERWLTTDEEQLSVMNRHWIPFGLGSRTCLGRHISMLEISKLIPKIVREFNYELDGDLAQMGTNWSTFNFWFVKPKGFQVRISPRHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN32</accession>
    <name>S0EN32_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to heterokaryon incompatibility protein (Het-6OR allele)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438312.1">
        <property type="nucleotide sequence ID" value="XM_023571270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN32"/>
    <dbReference type="STRING" id="1279085.S0EN32"/>
    <dbReference type="GeneID" id="35407550"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14098"/>
    <dbReference type="HOGENOM" id="CLU_004184_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="238"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT76266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="820" mass="92682" checksum="246AB9E5AFC83B9F" modified="2013-09-18" version="1">MDFPLQYKTFEYEALPSPTSIRLLRPVKQLKSPEAASINGVPLLQFVLEASERNDRPLYDALSYTWGNPKSVRYGLPDEYDTQHKHVIAVNGRLLYVTRNLHEALCRLQEPHRLSEDIDKRYMPYNKTRLMQAAEEGNLTLVMRYLEQGADHTCQDKFGETALHYAAENGYPEVVKALLFAGAQPTTLDNTNRDPLACCISRKRRRWGETCEILRDWLAQPKGKSHLEASSSGRGVPLWIDAICINQDDIAERNSQVAMMSQIYGSARCVVAWLGEEDDTTNAAFNCLSNIPQPSTAIARSYHNSYARHCDHVRGKVLDINERPHNLPMSVAEVQAVKSLFTRTWFSRTWVIQEASLAREIDIICGSFHFEWSSIFTLLFILFGESGSNDILSDGGPPAKFGKAGPNAQILTLFAIRSRTAPNSREAREARKYFLGKDIVDPPCSQLSILALFLLTWDFAVSDGRDKVFALMNVSEPSEGLAADYSKSIAEVFTEMGMTLLRAKGYNKVHDLQGEIVDDLEPLELLSFVQKPGTPQWKVSPAVMKNKYERPADLPSWVPAFNAQLVSIRIYHKLYNASGSRQAVIHNSLPGILKVDVSIVDTIAEVEEYPLSEGYGRINNDCTIESWLTIVSKLCTTYPSGESRTEALWRTLASEHHKKSKKPEAVESYLQNIVLQWIVKHRRQDSIERHEDLCKVLQELFNTESSDSPPPISKLISSNTESVGKGSEIGADERYFRWGLMRYMRGRCLMRTELGYLAISSKESRPKDHVVVIAGGRTPFILRQITANQFTFVGEAYVHGIMFGEWLRREGCNFQPVEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN97</accession>
    <name>S0EN97_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to aminotriazole resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437485.1">
        <property type="nucleotide sequence ID" value="XM_023570361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN97"/>
    <dbReference type="GeneID" id="35404922"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11460"/>
    <dbReference type="HOGENOM" id="CLU_000960_27_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="525" mass="57221" checksum="976009143F181496" modified="2013-09-18" version="1">MTETEKEQGFMPDPETDAPSDNNTLTGPDEEAISRTKSNVSIAETFSLPHEILFVAIICMAQFMTQAALGNCLNIIHIIGDSFNLTNPAELSWLIAGFSLTVGTFILFSGRLGDIFGYKRLFLIGFVWFAVWSMICGLANYSNHVLFIFARVFQGIGPALVMPNGLAILGASYKPGGRKAVAFALFGACAPGGCVFGALFAGLFVHGNPAWWPWTYYSFALGLAFIALMAYFIIPDPPHKLSSADMSWGDILGQLDLLGAITGITALVLFNFAWNQAPIDGWDKPYVFVLLIVGVLLVPVFFYVELRVASHPLIPFDALTSDVAYILGCIVCGWATFGIWVYYTWQFFQMLRGSSPLLTSAWMSPVAISGACASLITAWLLHVSHPALVMLLALTAFTTGTILMMTAPVEQSYWYQSFFGLVIMTFGMDMSFPAATLILSNSVKREHQGIAASLVSTIVNYSISLGLGFAATVEVNVTNGGESKHELLIGYRSAFYMAVGFAGLGLGISIIYFLKTKWYQRKGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP95</accession>
    <name>S0EP95_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438290.1">
        <property type="nucleotide sequence ID" value="XM_023571244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP95"/>
    <dbReference type="GeneID" id="35407574"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14122"/>
    <dbReference type="HOGENOM" id="CLU_106738_9_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="149" mass="16108" checksum="DB7E97454EE2DAF8" modified="2013-09-18" version="1">MAPVISDHELIRNCIARYCIGVDLKDWNTFSSAFLDNGKVDFPGPGGLVEGVTAITATVQGMAGNLQTQHALTTQLIEVTGEKTARATTYCTTEIFGVGEDKGKRVTSWGLYQDKLVKGNFDGRDNWKIAERIATLAAPLMGDLSLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPB0</accession>
    <name>S0EPB0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_10883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436891.1">
        <property type="nucleotide sequence ID" value="XM_023569717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPB0"/>
    <dbReference type="GeneID" id="35404347"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10883"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000217">
        <property type="entry name" value="MFS lactose permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF70">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT74813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="533" mass="58635" checksum="62E9C1F3DDDCC42A" modified="2013-09-18" version="1">MDYKADEKVAVDHGDEVHDAHVAVQLAHDVENQKLSPWTPRMFRLYLVLACAYLCGCLNGYDGSLLGGINGMKAYQRYFNMSSEGSSTGIVFAMYNIGSIAAVFFTAPVNDFFGRRWGMFTGAIVVIIGTCVQATSTGRGQFLGGRFILGFGVSFCCVSAPCYVSEMAHPNWRGTITGLYNCTWYIGSIIASWVVYGCSYIDGDIAWRIPIWCQMITSGIVALGVLWLPESPRWLIAQDRVEDAVQVLATYHGEGDENHPMVVLQIKEMSNQIAADATDKSWWDYRGLWNTHSARRRLIGVLGMAVFGQVSGNSLSSYYLPVMLKQAGITNEKKVLALNGINPVLCFFGAILGARLTDVVGRRPLLIYSIIFCSCCFAVITGTSKLSLDQPDNASAANATVAMIFIFGIVFSFGWTPLQSAYIAECLSTDIRAKGTAVGNLASSIASTIIQYSSGPAFQDIGYYFYLVFVFWDLFEAVFIYFFFPETKDRTLEELSEVFEAPNPVKKSLQKRDAQTVMNTLNVTGDAKLAGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPL3</accession>
    <name>S0EPL3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_11369</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437396.1">
        <property type="nucleotide sequence ID" value="XM_023570259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPL3"/>
    <dbReference type="STRING" id="1279085.S0EPL3"/>
    <dbReference type="GeneID" id="35404831"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11369"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="686"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT75350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="741" mass="80660" checksum="0E3C41D1A3DE8FB9" modified="2013-09-18" version="1">MTSDSTLMEIDEMTETTPLLPSHKRGTKAAPTNTASQQDSLPYSDYHTIDWLQDLVQDSHRRDNSSLYLRRGIRYRITKLWDSSQGWVAAFLIGLLTASIAAFVDVSVEVLADLKDGYCTNNIFLSRRACCASEMNCQNWKPWTESYMHAYAIYVGLALAFGTIAGIVTATTKMNLTAIAPEKERSRASIESPGGKVMYMAAGSGIPEIKTVLSGFCIPHLFDLKVLIVKAIGSIFAVATGMCLGKEGPFVHISACVGYLVSICIPKYASNQRKLREMLSIACSAGLSVAFGAPIGGVLFSYEEISTYFPRRVLWRSCLCSVVAAAVLKELNPTGTGKLVLFETNYGVNYDALHYLVFVILGVCGGIFGGIFCQANFLWSKSFRKISIIKNNPAFELALVALITAVLQFPNILIRETGDIVMQRLLVDCNHAEEDWICQKEAQTTGKGTYYAWLVSGTFVKLFLTTITFGCKVPSGVIIPAMDAGALFGRMIGQLIPNISPGIFAMVGSAAFLAGVSRMTVSLAVIMFELTGEVNFIPPFMIAILTAKWVADAISADGVYDLAQHLQGHPFLEAEGAISKVREFRYNEGTATVDALLPSKEAMDNAIVCVGANYRILTSVLQHRLSHLQSSGLSDSGLVIVNDKGLCHGYISQYKLEQALQMIEKTDGVEESCEINVLEGNLAEAIDRSPLTLSSKAPLEYAVELFGKLGISYLAVTEEDTARVLGVLSTKQLIAFLDMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ37</accession>
    <name>S0EQ37_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438266.1">
        <property type="nucleotide sequence ID" value="XM_023571216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ37"/>
    <dbReference type="GeneID" id="35407598"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14146"/>
    <dbReference type="HOGENOM" id="CLU_270225_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="401"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT76220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1206" mass="137657" checksum="29B4614EE15F56D0" modified="2013-09-18" version="1">MSFIRKFKRSKPGPVPASGPISDVGLTLIWEPDNGNTEVDVVFVHGFTGHPQKTWTFQGSKTTTYWPRDKVPQTLPSARVWTFGYDTKIGSPFRPENQNTIYGEGKELVASLADVRPANEENVPLIFVAHSLGGIVVKQALRYSEKCREQLANRNLGLIYDSVIGILFFGTPHGGADPRGISHHIVQSLAKIAGVRVNPNTMATLLPSSAELEQLRDEFLPLVRKNRWTITSFQEQRGTPLLHGKLVVEKACSSLGDVDIERTRAMNKNHGDMCKFSEEDPEYSKVDRAFKHAWESWTMELRMSLKAKWRGSISEDQRKQLLSTLWWSEMNARENSIDHTSVETVQWIFDSPKGASPRTNQTTSSNGQAALTGTAGRFYLDCVKEQDTGSLLQLWLESNESMFWIRGKAGCGKSTVMKFLINDHRTPRYLQKWQSSVRILRFFFVEVNTSPLQRQVQGCCRSLLYQVLNSECALLDNVLQNHPYLATKQSENDWSAKELQETLTYILEKSETAFCLFIDGLDEVPNEHHGLAVELMTALANIQNVKVCVSSREENSLSGLTPCSSLHLQDLNRHGIKAYIEQRLAPRLKTFGDTEDKIFSWKVHRLKYTLVEKSCGIFLWVAFAVRSLLRGIDNGDSLQILYQRTSEFAPSLDDLYQQMWSRQNMDQHLYRQESAQIFWMMLDSHHEPNQWMTTFVGNLFLTNISLSKEILGILRIGRLATIQQVQLLFKKHSRWLSARSAGLVEHQSHISAFVEHRASIPLSLPLSKQSEVGFIHRSVREYLLNTPSGRVLLGYDTRDPEDKWLRSLEALEGTAIFSIVYKTNIFADYVRMIPLLLPENMETQACASFAGLVACHVVIGHVSVDDELRLLNDFSDMLGAVSQTKSLQLAMFICAAAYGASQFLSQSRGRILATLTTDEQNAILFSACDIFETHEEITSMIPDNWMKSMDMQEYNILTFKMIRRSIGSVKYMLLANADAQAVFPVLVKNSLEKTTTPFLACLRRLFKVIASLTFIDRYSDEFDEDEAYSNELKLLYLDIGACIRVFNTLLPSTGYVILDKNDYGAFCLDTQPLPFDSRVAFAVSTRWFVEFFQMRELFWKDPSRWHENSVVHDRVPYVKCIVLESEVKRRRCERPPKNIEDETLRDEKLKLEAAFEELLWDRGSWRHERGRIFAAQSRDLDRKFGDIVCKVLDSLYEAGSERLSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI43</accession>
    <name>S0DI43_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to AAC-rich mRNA clone AAC3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_01488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424085.1">
        <property type="nucleotide sequence ID" value="XM_023578151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI43"/>
    <dbReference type="STRING" id="1279085.S0DI43"/>
    <dbReference type="GeneID" id="35394973"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01488"/>
    <dbReference type="HOGENOM" id="CLU_045202_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000870">
        <property type="entry name" value="WD repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="336" mass="36536" checksum="3076D431CD7C2506" modified="2013-09-18" version="1">MAPVLRARQSLSKDKFSGYFGNLRSQPYNDPNNSRGSNPHSLRCIAWNPLGTLVATGSSEKTLRVWNPEKPHVKFSTELKGHSASVEKVAFNPTKDAELCSVSSDGVVKFWDVRTKACFNEVKGLGDAFTLVWAPDGATLLVGNKADTIFVLSPSQSTPLSTHQQSVQTNQIAFCWSGEKIFVTTAEGRIRVLSYPGFQPVLQSKHGEETDEFELNGHTSSCLTADLQPTGRYLATGGSDSIIALWDTTDWICQRTITRMVGPVKSLSFTFDGSFVVGGSDEGSGLEVSHVETGEHVHTFKTAGACPVVAWAPTRYCLAYSDLGILRIVGVDVDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0DID4</accession>
    <name>S0DID4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_01555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
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        <property type="protein sequence ID" value="CCT61945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023577406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DID4"/>
    <dbReference type="STRING" id="1279085.S0DID4"/>
    <dbReference type="GeneID" id="35395040"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01555"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="Helicase-assoc_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
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    </dbReference>
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        <property type="entry name" value="DEAD"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="118"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="334"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="99"/>
        </location>
    </feature>
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        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
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            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT61945.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="777" mass="85675" checksum="B1242EFD06AE63CC" modified="2013-09-18" version="1">MATDNSGPPPAKKRKTKNKTDSNAITIGGKTISLEGYLTAPSKAVPIASSTSASDSPVATPLAAPVATTEAKKQRPEHKKPSRGCDTSDRSRARDDPKLLKTRKELPIWQYREDIQKALRKSGSDVLVLVGETGSGKSTQVPQFLYQEPWCRRQKIKIGGSDDEISVGGMVAITQPRRVAATTLAHRVSQEAGTPLGKGRRDGLVGYSVRFDHQVPKGSRIKFLTEGMLLQELLRDPNLSSYSAIVVDEIHERSLDVDLLVGFLKQILASDLSGRGGIPLKVVIMSATADVEGIQEFFKDVRPKNEGESTLQVLKIKGRQYPVTIHHEPRPVPDIQDALLKTIYKIHLQEQLPGDILAFLTGQEEIEAAQKLIEEYAETLASNVPKIKVFPLYGQLSMDAQREAFLPVKTPFTRKIVLATNIAETSVTVPGVRYVVDCGKAKVKQYRARLGMESLLAKPISKSSAVQRTGRAGREGPGKCFRLYPESAFKTLQDSDLPEILRNDVLGAVLTMKARGIQDVLAFPLMDPPETEAIEKALIHLHFLGALNDDGTITRTGETMARFPVSAPLGAVLLAAADPEFDCVVEAIDIISCITSGEDIFLSIQSEQAQEEVENFRKELQRREGDIITYLTTIQQYTAENADRVNWCKQRKINMRNMKQALNIRRQLRGMCLEEKLLDEAPPADPQPFVPISPERAEQVLKCFLRGFALKTAMLAPDGSFVTIQGKHVVAIHPASVLHGQKKEAIMFLEHVYTNKNYAKKVSAIQATWIVEAMGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIJ7</accession>
    <name>S0DIJ7_GIBF5</name>
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        <recommendedName>
            <fullName evidence="6">Dynactin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCT62030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023578473.1"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
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        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47637" checksum="2835AAC0A121FB4D" modified="2013-09-18" version="1">MALNRKYAALPDLDSAPDIYETPELTDDNSTVPTTTARTHSDDEFYDIEDETPGISRSRLRIDEARSRFLPTNVDANRVDFSDRVDGKRKAYKVSSRRQRILQDGTQELGDLSDDDDDESLERRIARLKREVEEAKNEYAKRKAESQTKENIDATTGDDRLTSLSQVLDEISQPTGRPTSIRIAGANVTSNSEEKTEAPSTEDATYTLMYEPTYEQSHALAKATDFDRRLLMLERGLGINASLMQESEANGLPRAILPTLDSMNKQISTLAEASTANLDAISRRVRTLAQEQDKLNDSREKARSLREELGRNGSSAQSEETEQEAKINALYGILPTIENLTPILPPLLDRLRSLRAIHSDAATASETLARIEKQQAEMATELKQWNEGLVKIEAAVKDGSMSIEKNKQVMEEWVKDLEERMEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJA5</accession>
    <name>S0DJA5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable LSM2-Sm-like (Lsm) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424650.1">
        <property type="nucleotide sequence ID" value="XM_023570263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJA5"/>
    <dbReference type="STRING" id="1279085.S0DJA5"/>
    <dbReference type="GeneID" id="35394354"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00869"/>
    <dbReference type="HOGENOM" id="CLU_130474_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT62569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="120" mass="13871" checksum="FE545F2B62EC3FA0" modified="2013-09-18" version="1">MLFFRYHRTIFSVVNALVRTLTRYSYSFFKTLIDHEVTVELKNDIQLKGILKSVDQYLNIKLDDIQVVEELKYPHLSSVKNVFIRGSVVRYVHLPGASVDTQLLEDATRREAAAQQAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJD4</accession>
    <name>S0DJD4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to atp synthase epsilon chain (Mitochondrial)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424700.1">
        <property type="nucleotide sequence ID" value="XM_023570896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJD4"/>
    <dbReference type="STRING" id="1279085.S0DJD4"/>
    <dbReference type="GeneID" id="35394297"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00812"/>
    <dbReference type="HOGENOM" id="CLU_187039_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="72" mass="7960" checksum="26EC9B0445D991B1" modified="2013-09-18" version="1">MTAAWRAAGLTYNRYLAIAARVVRRSLKEDKRIAAERRGEMDLRFSKWQNGKQGEPKNLAAANAAIAAENAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM00</accession>
    <name>S0DM00_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425551.1">
        <property type="nucleotide sequence ID" value="XM_023573725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM00"/>
    <dbReference type="STRING" id="1279085.S0DM00"/>
    <dbReference type="GeneID" id="35393537"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00052"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="49"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="285" mass="30940" checksum="52FDC8A26378D72A" modified="2013-09-18" version="1">MEPGIAILADPNFPLDQVTTRDFFADTSDGQNILLRWYSSNHKSPSLAVIYAHGGGMILGSVKAYDKVVAAYVARTGVPFLAVDYRRAPEHPHPIPVNDVYAALNWLVAHSEELGVDTSRIGIMGDSVGGGLAVVTALLARQHDGPCIAKLILVSPMLDDRTVSADEHLTPFLSWNTTDNETGWQALLGCSRGREVVAETAAPARMVDATGMPPLYIVVGELVVFRNESIELATKFYKSGISAELHVYPGCPHGFDIFPSRETGVCKRAFENRDRAFKSIFPANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM26</accession>
    <name>S0DM26_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05173</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425755.1">
        <property type="nucleotide sequence ID" value="XM_023571453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM26"/>
    <dbReference type="STRING" id="1279085.S0DM26"/>
    <dbReference type="GeneID" id="35398654"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05173"/>
    <dbReference type="HOGENOM" id="CLU_011226_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="95"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="225" mass="25879" checksum="F4D2498280976D89" modified="2013-09-18" version="1">MSPLTLYTDSRFPCPQRLQLVILELGLDITNIHEVDIIKREQQKPEFLELNPFGAVPCLQDHSHDPVLVLTESRAIARYLADRYGRPDNKLIPDGEVAKAKFEEATSIELTSFDAVANPLAFEAYFKSQFMNQEPKEQVVKDLKVRLERVLRLLDQKLSTQPFMAGEAVTLVDLFYVPYMHYLQDGVWPTLLEAYTNLLAWWNRMKGRASYRQIYVDGNNGIDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM67</accession>
    <name>S0DM67_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424553.1">
        <property type="nucleotide sequence ID" value="XM_023569063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM67"/>
    <dbReference type="GeneID" id="35394462"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00977"/>
    <dbReference type="HOGENOM" id="CLU_032739_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="414"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="486" mass="54565" checksum="9B83DCBCF78504E6" modified="2013-09-18" version="1">MKKLPFKPTALRRAAPKPKPTQSEDSKDSDDDGLSLFRRSKEMAPIMAAEQQRRWKRHREAEQEAERKRLEAIGEKRPREDSPDSDGPTNKDSGPEVSDGLPSLPERVEGTPVTDQPLTHDGADRTSELVTPPPSKRSRLDSSSAQKPILSSQLDIDEDPFPDASPTRRLGPIHNPPTPSRNLKTEGFKPQAKPKTDPITIDSDSESDSGPPKPKTDLSSKPGSSSIELAERTSKPSKEPSPPPVEEDEFAEYIRKAEEKRARQQALQANKSEEQSKDAFNIFITSTIPHTVPLQVRFSFNKPLRIVRDAWVNHQIRKGVSIQADDVTLTWNSKKVYNTSTLVGLGIRPIGNGRAVSDGQGSAGFRENMSSINVQAWNPELFQKMEQEQELQRKRDAGEISGEEEEKPAERIRFVIMLKGRDVEPLACKILPETTVETLISYFRQQRNVGSDKQVSLWWDGERLEEHVEMQDAEIEAQDTIEVHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMG6</accession>
    <name>S0DMG6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425721.1">
        <property type="nucleotide sequence ID" value="XM_023571411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMG6"/>
    <dbReference type="STRING" id="1279085.S0DMG6"/>
    <dbReference type="GeneID" id="35398691"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05210"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="324" mass="35895" checksum="1AA9020188F5661D" modified="2013-09-18" version="1">MPPLRQPKVEPLPPGIDLTNKTAIVTGATAGIGLELSRQLLDLNLSTLILAVRNISKGEEVRNSLAVINPQAVIQVMKLDMTDYATVKAFAETFKSKHGKLHLLLLNAGISDVNFELAPTGHEKNFQVNYLSNVLLTLLLLSALEHTAELEGAPTRITWTGSRMHWQTSLASKAPLKKDEGIFEHFDAPGVIPSLTRYGDTKLLVLLFQHELANRYPPKKVIINHFCPGMVDTSLTDVLPLYIRLPALMLKALRARSVDKAGWIGLHAALVVGEETHGQLLGDKEVAELGDFVPSEEGLRIRKLLWDETVEEMRELTQLPSWME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMQ2</accession>
    <name>S0DMQ2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to pyridoxamine phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423919.1">
        <property type="nucleotide sequence ID" value="XM_023576129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMQ2"/>
    <dbReference type="STRING" id="1279085.S0DMQ2"/>
    <dbReference type="GeneID" id="35395155"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01670"/>
    <dbReference type="HOGENOM" id="CLU_054794_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF1">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="276" mass="30533" checksum="9B58E769CACCE35E" modified="2013-09-18" version="1">MKLYPSISEDLATWVQQQPVFFTGSAPTHGSHINVSPKGLSDSHFAVLGPNQCAYIDRTGSGCETIAHSYDNGRLCLMFMSFGPAPRIVRFFCRSRIIEWDDPAFPDLVRRISKGKRSTFDGARAIILADVFEAQTSCGFGVPRVKRGIYAPDETSEKNLSLEQVLQEGVDGKVNELAVFEERPTMDMWVAKRVENNTLLDYHKETNVLSMDGLPGLRAARRSVGETLWFTDAKAHARKVFAQSEAIAVGFVLALLLYVVMVSLGAISASWPRTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMS6</accession>
    <name>S0DMS6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425985.1">
        <property type="nucleotide sequence ID" value="XM_023571732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMS6"/>
    <dbReference type="STRING" id="1279085.S0DMS6"/>
    <dbReference type="GeneID" id="35398405"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04924"/>
    <dbReference type="HOGENOM" id="CLU_086423_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="202" mass="24092" checksum="1712A3A669C8A237" modified="2013-09-18" version="1">MAEVAKTVARQLPGFKLGQKQVFLPNHVITFLRKDHLPPNEATFQVPLRFTKFDLRDYLWNLYNVEVTKVRSYVKQQPLTQRNSHSRSWYRPKPLKVMTVELAKPFQWPELPEDKTPWSNQLFQMREDMLEKRNQQHIAQQRFEIPLKSKQLPSKERQELAKMAQKLLSGEEKWTNDVILDPKWEKILNKEEVEVKKDANEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMZ7</accession>
    <name>S0DMZ7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424833.1">
        <property type="nucleotide sequence ID" value="XM_023572541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMZ7"/>
    <dbReference type="GeneID" id="35394149"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00664"/>
    <dbReference type="HOGENOM" id="CLU_038276_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="375" mass="41651" checksum="A5CE93964041DEF5" modified="2013-09-18" version="1">MHASKIIASIGLAASAHATVIRYERDLEANAPAAALEKRAEPTAAWVTVDDEMQPATTYTPSYTTVDGTTSLIDAPPHDLTASVYTYTSWGKIHTSTGEPPNPQATGKHGEGVFARCYNKDGDNAPFCSPYANSTLDVKNTYFVTWDPDYFNKTKSSDNSTLLVTARLDLYNRTSEKWVKYKEFTDSAVPAAWGYWPFDVKQDYMKYSPYNISITLYSNSNNSLEKTKSSSLYLNLNDQNFPEKSHEKLPEGQTLTIALPVVFGSLFLLLVGGFLWNRKTRRIGLGNISSRSRHGYTGRAKRRIFGARDNGIQLDTSVPPPGEYRDAPQRARADSDGLGSLAGSPVDPTFPQQGTTGGRNAFRDEVRRQEEERRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN43</accession>
    <name>S0DN43_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to thioredoxin domain containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425942.1">
        <property type="nucleotide sequence ID" value="XM_023571677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN43"/>
    <dbReference type="STRING" id="1279085.S0DN43"/>
    <dbReference type="GeneID" id="35398454"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04973"/>
    <dbReference type="HOGENOM" id="CLU_021868_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484743" evidence="7">
        <location>
            <begin position="19"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="287"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT63861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="757" mass="85692" checksum="EA6432D791123CED" modified="2013-09-18" version="1">MRFSPLAILAGLSAVALAEEERNPVTDPTTFNGKSVPPFKELTPSNWEEETKKNKFWMVKHYSPYCKHCTRFAPTFQTLYEFYYTSKPPTENPDDTFTKYYDFAFGTVNCVAYYDFCMDHNIQSYPTTILYEDGKVFDTLRGIKNMTALTTSVENALSKTHPGRPALVELPQPGDTVYPAPKAEEPAAEKKVEGAQGDAKAPVEKPAVNAEKPLDAVAEKPVEEPAGKNAGKSLDDITELPKDAEKSDKTESTEKKPEESAAAKDENKNTFGADWKVPTTGQMLKKTKPKDTTPKYNLEGTSVPLTPENFDKLVTSSKDPWFIKFYAPWCSHCKAMAPTWQQLAKNMQGKLNIGEVNCEADHKLCTQMGVKAFPTIYFVTGTEKAEYKGLRGVGDFVAYAEGALEVAGGVIDVDAESFKELEKTEEVLFVYFYDHATTTEDFKALEALPLNLIGRGKIVKTSDTELCSRFKITTWPRLLVSREGRATYYTPITPDEMRDVDSLVSWMKSTWLPLVPEMTAVNAKQIMSHKLVVLAILNRNDEDRLQISISELKNAANEWVDRQVQEFQLERKKLRDAKQMRIEEAQSRDDQRALRNAKAIKIDMDSTRRKEVGFAWVDGIFWQRWIATTYNIDVRDGERIIINEEDRHQFWDTTPTGNQIMVSHTSIMDTLDKIVYGPNPISPKYTIGTLAKFFFDIKMNFVDHPFLSMGFVIAVGFGLYSWIRNRTRRSRGTFFRMDDSLGLKDGLLGQNGNDKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNK0</accession>
    <name>S0DNK0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424229.1">
        <property type="nucleotide sequence ID" value="XM_023579939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNK0"/>
    <dbReference type="STRING" id="1279085.S0DNK0"/>
    <dbReference type="GeneID" id="35394814"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01329"/>
    <dbReference type="HOGENOM" id="CLU_021798_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="407" mass="44012" checksum="24408B6C4C81F9A5" modified="2013-09-18" version="1">MPRPGLPLTPGSSSDIKGKDGTQQLSSFQLSFELPPPAIHDASRISPTMSSQVSPTDTKPHRLTTTSPGATYPMQPAETVKARRRSSVAKDQKDNSFALPPPPTRSRKIIQMKPRQDGNGDNGGSKDKAKTTSKNAVSAKTTTAANSKIIASEKGDAAADDKAKKKQPSATSAAGRKIARKTAHSLIERRRRSKMNEEFAVLKGMIPACTGDMHKLSILQASIEYIRYLEDCVSKLKAQQEEDNGQTESGRQTPTGRDRLPSIREFHPTFQEDPVGDEDVEMEDSDVTSPAMTAMSDRNPRHPSVSPALPPQDSRNRAQSYSSVSTDHRRYSYSVSAGTSPAFGPQIYGAPHYARSDASAPGSALTSPALNPQSELDQEAMAALLMLNNDRRDSKGRGLSVRDLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNT9</accession>
    <name>S0DNT9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Folliculin-interacting protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023571945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNT9"/>
    <dbReference type="STRING" id="1279085.S0DNT9"/>
    <dbReference type="GeneID" id="35398214"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04733"/>
    <dbReference type="HOGENOM" id="CLU_007239_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028084">
        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Folliculin-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="89"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="218"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="905"/>
        </location>
    </feature>
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            <begin position="1045"/>
            <end position="1064"/>
        </location>
    </feature>
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            <begin position="1105"/>
            <end position="1128"/>
        </location>
    </feature>
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        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
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            <end position="184"/>
        </location>
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        <location>
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            <end position="259"/>
        </location>
    </feature>
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        <location>
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            <end position="274"/>
        </location>
    </feature>
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        </location>
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            <end position="781"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1209" mass="132722" checksum="F556771A9AD591B4" modified="2013-09-18" version="1">MLGRLLHLGSGGPSATPTQASTKTSRPVSSLDSAQEDMVTRNLLFPDADALYQHRNDQVFPLSTTPTTPATSTANAFDYSGDVDLDVRDVRVIIMQDALGPSNATLLFDSHPAPPVSPTERPPIPPEFRRTPTSPRKSSLGGLSRPLVIQPEGPQPSPRQGAFDRRASLQGRRDSHVESDGQKAAREYREELATFSSCIFGNSELMSYKGTSTKVHVVPGESRPAEPSSSIVGDGRSSIGRSSARSSRLSQSFSSQAFSPTNMSAAQNHTSTSRPAEKKKVLITRLFPVNLTIDDPETNVSPSKDDAEENAGFPFPTTSEESVPKKKKPQPKQRRTPMYAVVLVVQLPAANNTTTRMSPMNQSKSAQRESSSYNDQEFFPSSFSSARPSGWTMVGSGNGDGSDTYTLDMEDRIDSLIRHWDIIMRTLTHLQSVVATTLATLLKQVDLASPGPAPGPVPPLVVTNKTGRAHSFSDQYRGDMSRIKPSKGTTKLVYLWPNCLTDDKTVIREVDTARQRIVMGLSAARVVTGQGRWGIWRDEARWASKWVAGTDNQNQFLYNLLTGFLSTHTDWLQALCPPSYRRRLYLQQKNRNEEDLSLPARTIIVSDDKMVARRLIFLLSAFLPANSHFPTTRAHRPSTSTSVGTYSNSPPTFVIPVLREESLRRKINRRTGLRRASHSRTTSQSARASAVPMQLAHLTMDRNHERRVSDAASIRPPNFAMFGNDVVSRKSSAATTTTIMPETTIPHFSTAQRVESQRRPRPSSSGSVATDDLKRSLKRGESTGALSNASSDSRSQSSRWGSVIGALWNNRRRDSASFSTYGGYDPKSPTKASFHRADKLSQMVEETSLADNTSVPSPSDRRPSTDALKGTGTPRECKGHSREPSIRPDRTPDPNGAFESPVKTSINADDGVIDVDISFPDYMTSFESAISSPSSSGYLSTPGLQSGLESFEQASRLCIDGDLPLNAAGWLNRYHPDFALQAIPPQEDLMVQIKASLQAEPTPPPAHPILGDLNERWVDISSVMIADTTTNSITRLRYRRLVKPRSPADHRPLTGPPGLSTSYGGLLTPSILPYETQLEEEWIEEPVLHPDETLTDAVERVISLSQDTSKDHSLASSQTHSDTRMSTEVEEPLSLTAPVTPALPQAPLEIPRVQCKTVVLSALEDSIREVIDIREKRHLETNHARNGRSRSPLHDAIGLWLDNLDINDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNY2</accession>
    <name>S0DNY2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_04677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426217.1">
        <property type="nucleotide sequence ID" value="XM_023572009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNY2"/>
    <dbReference type="GeneID" id="35398158"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04677"/>
    <dbReference type="HOGENOM" id="CLU_066261_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT64136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="358" mass="39108" checksum="AADD4A106187D3A6" modified="2013-09-18" version="1">MNKKSALIYIRAPNLDYEPDKAIRLGHIWKHPMDPGSFCGPPLPIPEDMETNHTFKAPWHIGKGRANSGSLGIWANFLQAVGVTAESNFDWNNANDVSHTCERLDTYSIEPTDNYVKESVKAVAAEAVKRRQRLFMVTGVKIARGAVGSISSSRRVGGGARAGFGGESFGVPFDGGPQFNISRDTYDEETYGESSDFVFAYRVRRIIYPKGGWESMQAGSSIVNYGRCETDVGASVLAGLRSRPFNSRLEFSEADEAEISGPLFFGYPSTWQEVCESESEGKGKGSLQDGRAKHGVVVSPEVGYFAGSSGAKSYFSSEIDGLILGDDRFVLGEFGHEADLIPFVDDSREDGLFISFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP46</accession>
    <name>S0DP46_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to hexose transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_04596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426287.1">
        <property type="nucleotide sequence ID" value="XM_023572100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP46"/>
    <dbReference type="GeneID" id="35398077"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04596"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF66">
        <property type="entry name" value="MFS HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT64206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="556" mass="62484" checksum="B719469356889486" modified="2013-09-18" version="1">MALPKFLQPIGSKVPAHSDRVPLDIAQAEAPRFEKVIWYKEPHLRKLYFLIIFLLIASATTGYDGMMVNTSQQMDKWKEYFPEEKNESKLGILINMYNIGSIVSFFIVPYLADNWGRKPTIMLGCVVMITGSFVSAFCNGYGMYMGGRFVLGFGNSLAQMSSPMLLTEICHPQHRGPLTAVYNCLWNLGSLIVSVVGWGTASINGHWSWRSITFIQAVPSIIQLCGIWWVPESPRFLINKDKSEEALQVLAKHHAGGDVNNATVQFQYREIKETIQADKSVTSTRYIDFFKTSGNRWRLAIIISLGIISQYSGNALFSNYMDVIYEGAGIKEQNKKLALSAGKTILDLSISIGAAFTVDKIGRRPLFLTAISGMVFAFILWTLTGGIYENSQFKTPPTEEQPDGGVAYSNTGAGYAQIAFVWLFGIFYDIGFSGLLVAYALEVLPFHLRAKGMMIMNITVQAILAIGNQTNKLAWNNMPNHWNFMLFYTLWDFCELIFVWYFYVETKGPTLEEIARIFDGDDAVAHIDLAQVEKETNLTRHESNTFEDYPPPKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ71</accession>
    <name>S0DQ71_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426676.1">
        <property type="nucleotide sequence ID" value="XM_023572579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ71"/>
    <dbReference type="STRING" id="1279085.S0DQ71"/>
    <dbReference type="GeneID" id="35397649"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04168"/>
    <dbReference type="HOGENOM" id="CLU_294559_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="909" mass="100079" checksum="B9F633BB504E7506" modified="2013-09-18" version="1">MTPKTRSGGKPAPSRVYHSTPAQQQAQFPARRKVVRTYGKQNRKKQAETPSRLLRQQTLTQIDFVSSLEGNEDPIVLSDSEQDEMQSDKDQGDQEDQEEDEEPVSSGRKRRAKAKVTSTKNERAKRRRTLGDDTEEQPNPKKEKKSSRRKTMGDAPSSAYHTQTLTQFLGRDPSHAEFIKDSEDEDNDDDFQQWLGNAASPSPRKTRKHRNASPIKNQKTPKSILKRRPEESTPQREESIVPQTPHKQTPHKNVQLTEIPSSSQLSAPPSISSTPASMMLERYGPPDRANPSPVKGKTSSPANPSPLKELRGRPKTTSSPRKHERIIQDSYATDSWGSINRTPLKELPVDSPNKTPRTPKGVIEPLETSSSVMAELETPTKSRRRRSSELGGSQRSGSPTPRMKRVSPGSGKKVMLEIPDSEDEEDEDFGDENDEIAFVAGAETQLVMSEIASSEEEVTRASSASVQTTTLKTKRRAVATISSEESSGSNGQASTSTSSLPPLSSRPTTLPPTLPPLSATPQAKSRPRPAKRVRKPIHSPLPPTQTQPLESQRVPLANLQALPPASARTDVLLSLPQDIIDDVIEGYQADLILDFKIPAQVVRFWLYDGELLRFMACADPGRVTEGPAWRYHLTQVYELNNPVEGDDMREEGWIDGDVARYVYFPPAVVGQLLWNLRHALFKENASGDEPAQTQATVGEDDSGRVDLFANSSQPLPADKTPGPSSSMSVSQQVEAQLKSDFAQSTQFPTSDDILVPSTPEEENNNNNNENTTPPTTHIASSPTTIKPPPRRTPFAASSYRATRPPLSSASKLPAVRPSQATTVSQSSTPEQHSSSIRRPPLHSSSSIGLPEGLLDEDDDDDALRLASGYNPGSSQLLTKSQMLPDSLIRDDTRVPPEIWDSDDDDDERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSA7</accession>
    <name>S0DSA7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427525.1">
        <property type="nucleotide sequence ID" value="XM_023574108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSA7"/>
    <dbReference type="STRING" id="1279085.S0DSA7"/>
    <dbReference type="GeneID" id="35395867"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02385"/>
    <dbReference type="HOGENOM" id="CLU_045148_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="23"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="270" mass="30820" checksum="CD534F026AC18CA0" modified="2013-09-18" version="1">MGYSGGDDQRQPSVTIPIAVCMGISLYNVIELNVLILTTFKTRKSLYFWSFLAATNGIAPHTIGFLLKNLVFSDNFVLYITLISVGWVLMVTGQSLVLYSRLHLIFWNQFILKLVLAMIITNAVVLHIPIIILMYGANSSDKNPWVHPYQIYEKIQVTVFFFQELIISAIYIKACSSFFGTEGLLYRKGVRRMRRHLLFVNVVIILLDIPILVLEFADFYDFQTAYKAIVYSIKLKLEFNLLNRLVDVAKGNDTRGAESGNQIVRLKAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSA9</accession>
    <name>S0DSA9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427406.1">
        <property type="nucleotide sequence ID" value="XM_023573969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSA9"/>
    <dbReference type="STRING" id="1279085.S0DSA9"/>
    <dbReference type="GeneID" id="35395742"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02260"/>
    <dbReference type="HOGENOM" id="CLU_597224_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF60">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="357"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="458" mass="51272" checksum="007F0157EF2386AC" modified="2013-09-18" version="1">MTVSDSKPHTHDWDAPLPPPQNAELQVRLPQPEPSLPRVLEPLPFPTGIIENLKHVVAYADQAGYLVSYAHERFNQLDADFHVQGKVLEERNAAIAQFKQEVKKLGDDLTVENAKVADLTKRLDEARATYEAKLKEKDEVIKKDEDQIKKVKGHDIDDHKTIDRLAAQLEYERASKAEVQKNLDQTKTALAAAEASLATASATIASLTTRVASLEAELEVEKKDIDKLQKETKDKTAIISQLEKNNADLQSKLNGALQDVRNKQDQINAKDSTIRDQSIRIDNLTKESNAKSITINNLQSQINNLQQQIRNLQSIPVFKFKCNIKCQAPSNREIAVDLTDGGGSGTPVQCYSLVNNNNQIWDIYSIGGRNNVVIIKNTRNNYVLWSAGRNQKARCDPGRDTSDQATQWELEGTTVDSINNNTDGMYLDLRQGDTSNYTPFMTWDGNNGSNQKFKISKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSH4</accession>
    <name>S0DSH4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to CAR2-ornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427471.1">
        <property type="nucleotide sequence ID" value="XM_023574046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSH4"/>
    <dbReference type="STRING" id="1279085.S0DSH4"/>
    <dbReference type="GeneID" id="35395811"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02329"/>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="483" mass="52315" checksum="B32DDF6E21A40541" modified="2013-09-18" version="1">MAPTNSLLYKNFQKHPAALLESTDGIYLNTSDGRKILDATSGAAVACLGYDNKDVQKAVAEQLVNVPYCHPGFYKTQAAEDLADFLVESTNGQMSKAVLCGSGSEAVEVALKLAKTHFAHLAIPQTERSHFITRVGAWHGATLGALTLGDFKVRKDPFVQLISQNSSRVSACSSYRGQRDGEDDEAYVARLAQELDDEFLRIGPEKVCAFVAETVGGSASGCAMPLKGYFPAMKAVCEKYNALLILDEVMCGMGRTGTLHAWEQEDVVPDILVVGKGLGAGYAPVSAVMINSKLVESFQKSGKGFAHGQTYMAHPQAAAAALKVQQIIRDENMLSHVDAMGAYLGTKLKERLLPMPYVGHIRGRGLFWAVEFVTNKKTKTPFPYDLGLNGLLHARGMSAGYEIALFNANGGYDGYSGDHFLICPPFIVTKEDVDEIVERTARVVEDTFEELGNSAVWEKITLQMEIDDVEVEVKPAAAMVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSI4</accession>
    <name>S0DSI4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427481.1">
        <property type="nucleotide sequence ID" value="XM_023574057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSI4"/>
    <dbReference type="GeneID" id="35395821"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02339"/>
    <dbReference type="HOGENOM" id="CLU_499692_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="544" mass="58427" checksum="31645158D0439BEA" modified="2013-09-18" version="1">MSSTNNPVASITNNSGSSVDIYDVFNPSTDPKMQGPLTYTKLATVSSGSTQQVQTIHFASQLQAMFTGNVTALSGTFYQQFPVAVLAVSPFADSNAFTVTSDNQQSMVDSFKFIKYTQANPSSQLATQFRTALGDTTNQKTAVNKFFQSTGSFKLCTLSTWTAVFTWQAQFTNPWQGTYYLYSLDKVPALVATLAITASTDNSSAVLTMAGTNNENTAVVMAGDGTMSEQNQGTGNLSVALTPTWLNVAQTSQQDGKAVSNYVIGAAFTGTINGQKVAGNLNQLAIPDPSDSSKNASNKNSANGFSLSMLEGLIGMLTSIGMLYYMAKGHKQAETQKKNDVEKDATSKKDAEDKVEKVEKDYQSESVPEVQAQASKVEATVPEVQQGYKGVNQAQDIQGKTDTIRQQKESMNEVLEGGAPSPATEDTAINLAKASDEVAGATDPNKSPEERDASLKDATTTLNKTSEDIQTALKDQAEELPKEEAQKLEDASEAIDQTQKEADAEKEVQEEQEKENEESPENEVEDSTFDPPEGREAPPFEGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSP9</accession>
    <name>S0DSP9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to high affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_02419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427557.1">
        <property type="nucleotide sequence ID" value="XM_023574147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSP9"/>
    <dbReference type="STRING" id="1279085.S0DSP9"/>
    <dbReference type="GeneID" id="35395901"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02419"/>
    <dbReference type="HOGENOM" id="CLU_013661_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT65476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="687" mass="76363" checksum="47B4839D620F2B2A" modified="2013-09-18" version="1">MNDFAAYQEHSREPPRREEPEWDSDRSVIFRETDNPNGIFTSAPKEAFKLGYFDVMCLVLNRMIGTGIFNSPQRVMEGTRSTGASLLLWLAGMIYCLSGVHVYIEYGLNVPRYTINGIEQSVPRSGGDLNYLQYVYQKPAYRRGTVLLSTCMFGFCFIALGNMAGNCISFATRVLYASGNTDPAPGAIRGIAIGIAILTCFIHTFSRRAGILLNNMLAIIKVMILLLIIVTAIVVGAGALKTTKGEKVKNYISENTQPSRAFADSGDANGYAHAFLAIIFSFSGFEQPNYVMGEISRPRRKHPIAMILGVGIAIVLYMAVNISYMVVVPEKDQISTNVAQEFFERTLGSLTEDETGQRIFNAFLAISSMGNIIVMTYTAARVKQEIAKEGIIPYAKFFAQDGDISLGRLLSWLKKKGMFSSLLSTRWLSPEDHREKTPVGAFVLHLTSCFILIFATWGMDYFNSYTLLTSLSAYVINAFFGIFLGLGILILRFKGPPQTDKDEIHSPAAVPQTWRQMTGKHINPTLSVLCAVIYVIGGLWPIVTIWIKPSTPQSLQWWLVPVITWSVIGGSILWFLGFVSFAWRRKQKRNEIFVVEKKPEFESADGSDDSGEKSSGYVLVHETVYLSWIAGEVHESRGTGRTGFDEQADTIPVPAASRYAGTDFEAFYEDDHRGAAPTRGYNTGYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSQ6</accession>
    <name>S0DSQ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426518.1">
        <property type="nucleotide sequence ID" value="XM_023572386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSQ6"/>
    <dbReference type="STRING" id="1279085.S0DSQ6"/>
    <dbReference type="GeneID" id="35397821"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04340"/>
    <dbReference type="HOGENOM" id="CLU_003608_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04486">
        <property type="entry name" value="YhcR_OBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485243" evidence="1">
        <location>
            <begin position="18"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="300"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="602" mass="65084" checksum="F664520580F312DA" modified="2013-09-18" version="1">MKLQFLVSSFISPLAAALTIAEINGNSYLSSYAGKNVTGVEGLVTAVGSSGFYLRSTKPDRNSATSEGLYIFGKSAVSSVSVGDVVTLDGLVEEYRSNKDYVYLTEISSPKNIVVKSSDNKFKPKVIGKDTGNPPGKQFSKLDDGNVFAVPNNESLISVSNPKLQPNTYGLDFWESLVGELVTVPKAYALSRPNNFGDFWVRGNWKVSGLNKHGGLTMVGSDANPEAIIIGSPLDGTKNPSDTKLGDYVGDITGVVSYAFGFYRILPLTATKVSKPSNAEHPAVSFTSKGSCKGITVADYNTENLNPASAHLPLVIKQIVEKLRTPDLLFLQEVQDNSGATNDGVVSANQTLAALADGIEESSGVVYEWAEVEPDNNEDGGQPGGNIRQAYLYRPDRVELVKPNQGGPNDVNAVVDGPSLKYNPGRIDPANPAWDDSRKPLVAEWKPVKGTKKSFFTVNVHFGSKGGSTSLHGDARTPVNKGVEKRTKQSEITAKFIAEILKKDKKAHVIAAGDFNEFAAVAPLQTFVKTSGLVDVDEAAKIPETERYTYLFDSNCQALDHMYISKELRRSIKYEHLHINTWQNTAGEVSDHDPSVAMFDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT89</accession>
    <name>S0DT89_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to Uth1p, Nca3p, YIL123w and Sun4p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425884.1">
        <property type="nucleotide sequence ID" value="XM_023571606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DT89"/>
    <dbReference type="STRING" id="1279085.S0DT89"/>
    <dbReference type="GeneID" id="35398517"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05036"/>
    <dbReference type="HOGENOM" id="CLU_026108_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053088">
        <property type="entry name" value="Beta-glucosidase/SUN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484518" evidence="3">
        <location>
            <begin position="23"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="348"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="496" mass="51590" checksum="24F0853FADB590C9" modified="2013-09-18" version="1">MRLINLSAALLGALSAPSMVAGKQHGHRHNGFEHLRQHLPVQSSTLEKRGGQCQFPTDDPNMVAVTPDAKNAGWAMSPDQECKPGSYCPFACKPGMVMNQWDPDSTYEYPASMNGGLFCNKNGEIEKPFEGKPNCVSGTGSIEAVNKCGSKMSWCQTVLPGNEAMLIPTLVTSSATLAVPGSSYWCSTAAHFYINPPGTGEEGCIWGTESEPIGNWSPYVAGANTEANGQTFVKIGWNPIWEDSALKSKLPDFGVEIQCPDGGCNGLPCKIDPANGEGNVGSSLSAKGAGGAAFCVVTVQKGSTAQIVAFSSGKGSSGGDDDDEETESSTAEAEPSTTTQAKVTTSKEPVVSTTEEPSTTAEPTTSALPTTTSSTSTSTTSVETTSSAESSSTTEQETSSETSSEEPTSTIFTTATSKTTKHKSTKKIYPTVKPGIFRENGTSTYTSSESEETAAATEVDSGAAPTQSKESEAGRHQGNTAVAGLVVAFIAAACFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTJ3</accession>
    <name>S0DTJ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to pleiotropic drug resistance control protein PDR6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_04936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425974.1">
        <property type="nucleotide sequence ID" value="XM_023571719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTJ3"/>
    <dbReference type="STRING" id="1279085.S0DTJ3"/>
    <dbReference type="GeneID" id="35398417"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04936"/>
    <dbReference type="HOGENOM" id="CLU_004909_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="12"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="175"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="716"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="716"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="757"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="864"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT63893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="881" mass="100124" checksum="DC25F22E0B81BE37" modified="2013-09-18" version="1">MAQPVPHQPTDKKRVKVYELRNNDWFDRGTGFCSASFETLEDGRKEPRVIVESEDHPDRLLLETKIQKEDGFQKQQGTSPYTLIVWQEPSSGVDMALSFQEAEGCAMIWFVLRFVSNVQQTFHNHLPGAGTKDRSSPRDYDTDNQCLDDGLSDDLPIDAPPAINLPTAELGNLGDIEQTMRMMSTTANGRDALAKAIMAEDFIGKIVPLVEMAEDLESLQDLHRLCNIMKTVILLNDTSIIEHAVSDECVLGVVGALEYDPDFPSHKANHRHWLGNQGRYKEVVPIEEEQIRRKIHQTYRLQYLKDVVLARILDDPTFSVLNSLIFFNQVDIVQHLQANAAFLNELFGIFRPTNSDQKRKKEAVLFIQQCCAIAKNIQPPARQTLYNNFIAHGLLSVIHFGLRHHDVGVRVGATDILISIIDHDPQMVRQTLYRQLHENQTLLTDSLIDLLLVEVDLGVKSQISEALRVLLDPGPQQLQNNEALAKANGEFMGRQRPQITIDPQQETFLNKFYEKSAPRLFKPLMDLEKRTDMNFTVQQASMFTYLIEIQTFFIRCHQLRVKLHVMSHDIVKRIAQLLACPEKFLRLVAIRFFRSLIAMQDEFYIKHLMEKQVLGPILEVLIETMPRDNLLCSASLEFFEFIKKENIKDLIKHLVVNYREKLRGLSYMSTFREILLRYDQTQGYTSNVDYFLEAEDEMGRRPLANTRMAEQITVEQEQEEYWATSDPEDDDDQSSKEGERTPSTNGSITSKLLVDYASDEETDENADPEATPEADSQHSDVASDAVHSPIDSSLGGGVPPPERLSEKRRREEEEDEDEMSKMMQNKRRSSSGSVTAILGNSRGPQRRKSFNVNSPTGGKKIAISLSSGLKTGSDPGSNEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU39</accession>
    <name>S0DU39_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426124.1">
        <property type="nucleotide sequence ID" value="XM_023571898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU39"/>
    <dbReference type="STRING" id="1279085.S0DU39"/>
    <dbReference type="GeneID" id="35398257"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04776"/>
    <dbReference type="HOGENOM" id="CLU_028608_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13394">
        <property type="entry name" value="Syo1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="419"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT64043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="655" mass="72035" checksum="D1AD4CF2985ED05C" modified="2013-09-18" version="1">MGKSRRARGHAARKDPIAKTVKPPSDPELAALRESKILPVINDLKSADPKSRSAAASAISNIIQDEKCRKLLLREQIVHTITTQTLTDAALESRAAGWGILRILAQEEEPDFCVHLYRVDILTAIEFAAKSITEMLLSKDLEFQKRSKPEQATILSIASSLISLLTALAEAQDDILEAISRNTTITRFLLLLTSDELASNPDIVSLRSDALACLMILCEDNEELSDKVVNSKEYRTYGTLLSLRKTANSDGVLACGVLHNLFSSLDGQDIALGADNSLLIPTLSQALKTFEPGQMTDAVGWANPVEYQQLALEILASIGTTLNTSAEAEPRKEEKPDVKDDEEMGDADEEISDGEEEGGEEDDDEMDDDELEADMEMVTGADRNEEDSNIDDLPILKTFIDNALPELIRIASLSPTDDASLRLQGHALSALNNIAWSVSLIDFSDLHNAPIQNAWDPVGRALWTQVIAPILATDTADIDLATHVTSLAWGVARSLRGRPNTPFADEHRRFIALYQATKGSPVAQNLEDPFQSLSVKCIGVLGQLALDPAPIDRNRDIGTFLVTLLAGLPETPTADAVEALNQVFDIYADEGYSYDKEVFWNNNFLKHLDETVPKVRTMIKSIDKRANSELRLRADEAVLNLNRFLTYKRKNKPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUM0</accession>
    <name>S0DUM0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to C6 transcription factor (PrnA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_03124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428206.1">
        <property type="nucleotide sequence ID" value="XM_023574936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUM0"/>
    <dbReference type="STRING" id="1279085.S0DUM0"/>
    <dbReference type="GeneID" id="35396606"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03124"/>
    <dbReference type="HOGENOM" id="CLU_009353_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF15">
        <property type="entry name" value="PRNA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT66125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="762" mass="85504" checksum="78E14FF9FAC5E213" modified="2013-09-18" version="1">MDKQQQTVQKSRQRREAERERKRALRACDGCRRQKEKCDGGVPCRRCTRLHRQCEFLGPTARDAEGGDGASRNRPGPGNAELLQRASYMEKIIAHYAGNVSLDTESLKAMAESIDNKNFDANQLKRQAPIMDSPGSDFLGAEDENYTVQPLDNNTTHYSGEFSHWNFSMRIKQWIEQCVPERHDAPGPLSFKEYYRAEELQSANNTQASLSALPPRYVAEFLVQAFYKHAETNYFYVERGWLAEQIDLIYQNPGALSRREVGTLCMIWIIFAIGTQYAYLDSISGRDAHGKSNDSSPFSEDTIGVMFYQQACKLVPDVITVASLESVQAILLIGIYTLPLDASGLSYIYLNLAVKLAIQNGMHRKWPAGGLDPYVRETRNRVWWTAYTTEKRVGIYHGRPLSILSKDVDAEMPTDRPDIMPSSPTNVAHMLATLRLNQALGKIAHEISVLRTAQKHEMNEGLQRVIDMKEELRRWWDALPETAFHEEVNPQNPITRADTHLKLEYCLLRMYAGRPFILPREVVRGNASTSSSPADSNNQRPNTPHKSNPRSILVADCVEAALTIIDTCHLLQSTIGLARASYTEFSSCRAALLVIITQCLQKKTDRLRDALRTGMAMIKEMSAGGESARSEASLIEVFERAISRLDATADSSGRETDYSRFKKWELLWKNDVPLQDFRQEESPETSLPLPQNPNAFWRGSTGTTARPGMPTMQAPSPFVGMDANFPSVPQVMDEFSTLFGYGFGPSPDSMAGTANGGMWMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUN5</accession>
    <name>S0DUN5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428390.1">
        <property type="nucleotide sequence ID" value="XM_023575163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUN5"/>
    <dbReference type="GeneID" id="35396809"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03327"/>
    <dbReference type="HOGENOM" id="CLU_1310182_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="229" mass="25031" checksum="0F3D3B31C0232F94" modified="2013-09-18" version="1">MTSNSLSVYSESLPAFAEQATCANSLWPRSSSLLPQMSSSAGPPNEGNSQRIVEDEIQALVERIDNNICEWRSDNGTNQTIDVEEVINVPNVPAIQAAENTEVDGLFCGTQPTTAWSKHMDCLAFHLLRVRDSLTAISNCFRSIMRTIDRNNVEESNSSGYTSNESFQFDGVSSGSYQQTGQSEVNPPTGSRIIILIKAMLIDERQLPLAWPRQTSSASFLPSSSFASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUV5</accession>
    <name>S0DUV5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428332.1">
        <property type="nucleotide sequence ID" value="XM_023575091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUV5"/>
    <dbReference type="GeneID" id="35396746"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03264"/>
    <dbReference type="HOGENOM" id="CLU_094297_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="190" mass="20636" checksum="D57A0F92DF683E52" modified="2013-09-18" version="1">MTSTAKAVAFSPAPYHIITYGTLLGTTFFHTFINGIVMFRTVDRPSFSAIQQKLFPIYFGLQTVLPGVLALTYPGNTLIGLSNGPAGLVSEFARWHSLLPISVMAFTGAVNLLVFLPLTVEVMKQRRGQVKRDGKEWYAEGPQSDQMKALNKKFGMLHGISSLFNLITFAAAVGYGFTLGGRVLSVADLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV96</accession>
    <name>S0DV96_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to toxD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427403.1">
        <property type="nucleotide sequence ID" value="XM_023573966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV96"/>
    <dbReference type="STRING" id="1279085.S0DV96"/>
    <dbReference type="GeneID" id="35395739"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02257"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="9"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="354" mass="38287" checksum="D1FB8392DE61CC5E" modified="2013-09-18" version="1">MTVANTTKALFIDLENNPKVIERQGLPKPSSGELLIKVLYSGVNPADIKHATHLGMNNTVMGHDFSGQVLETTNPNSVYKPGDIVAGITPAGLHSPVHYGAHQAYITCPEDLLYKVPDNLPPPDAASLTVVAMTAADAIFNQFKFPLPAENKRPAHDGPFLLWGATGSVGYCALQFAIASGVSPIFVTAKPAQFEHLRSLGVEHLFDYRDENVHESIAKALRDSGFDKFSYAIDAAGAPSSADQVLKAVADDTIVASVVIRDNKRFKFPVASSLQDFVIQPPGVPHPISIPSRPADHARAWEGLKWAAERYGKEFRLPPVRIVEGTAEHALEEIKRFVKQGGGFSKVSIKQPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVR7</accession>
    <name>S0DVR7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to dienelactone hydrolase and related enzymes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428735.1">
        <property type="nucleotide sequence ID" value="XM_023575575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVR7"/>
    <dbReference type="STRING" id="1279085.S0DVR7"/>
    <dbReference type="GeneID" id="35397178"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03697"/>
    <dbReference type="HOGENOM" id="CLU_032662_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="411" mass="45522" checksum="9D2495A8C61CDC48" modified="2013-09-18" version="1">MSENNFSAPPVLPAVRLRNPTVSLTILEPLSRRGSGPGLIILVPETGKATSDTLRIDGCVPSPLMKWAEEGYTVAEITEAGLANPSVALSQALKELEAAKSTEPKNVVGVVAYSTVLWNQIAPHVDSFSQISGAVIFGDLGDSDISAIASSKVPQLHHLAGKSSKRLQRTKEVTAYNYPEAISYLFATPFSKDFSYNMESVSHSRSLGFLKPLMNGPYFDLEVIWDEHTYWEFENRSVENTMSTMVQEPYVNHVPTMTGGIGRDKLTAFYRDHFIFQNPPDTETYLISRSLGIDRVIDEFIFTCTHHSQIDWLAPGIPPTGRKLEVPFTAVVNVRGDRLYHEHIGWDQGTVLAQLGLMPSYLPYPHPVPNAQGQEKLEYRVPIAGVETANKLRDKEAVESNGMFAFGLRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWD2</accession>
    <name>S0DWD2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable alpha-methylacyl-coa racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427783.1">
        <property type="nucleotide sequence ID" value="XM_023574429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWD2"/>
    <dbReference type="STRING" id="1279085.S0DWD2"/>
    <dbReference type="GeneID" id="35396152"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02670"/>
    <dbReference type="HOGENOM" id="CLU_033975_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="400" mass="43588" checksum="7474AAFA88DF765A" modified="2013-09-18" version="1">MLQHPPLTGIKVLEFAGLAPGPYAGMLLADAGASVLRIDRARPDASAPTEDMLARHKSSIAVDLKSERGVALIRRLVAEADVLIDPFRPGVLEKLSLGPDELCRLNPRLIYGRMTGFRRDGKYALMAGHDINYLAVSGTLGMLGRDGEKPHPPWNILADFAGGGAMLFEGILMAIISRQSSGRGQVVEANMVDGSSYLTTFPRMALKTIVGNSGRGNNLLDGGAPFYDTYETLDGKYVAVGALEPQFFAILLSGLEIAGQGWEEDQHNRDRWPELRHLMTDRFRSKTRAQWELVFDGTDACCTPVLEYSELENDPKREGDQRPAVTLRETPCLAMKEGVGLADPARLGQGPGVPGDGYRANLLKPGAGGEEVLRKWLGWENGTEYVLERGGFVLKELSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX88</accession>
    <name>S0DX88_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable AVT3-involved in amino acid efflux from the vacuole</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_13382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429270.1">
        <property type="nucleotide sequence ID" value="XM_023576061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX88"/>
    <dbReference type="STRING" id="1279085.S0DX88"/>
    <dbReference type="GeneID" id="35406836"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13382"/>
    <dbReference type="HOGENOM" id="CLU_009646_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990818">
        <property type="term" value="P:L-arginine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089708">
        <property type="term" value="P:L-histidine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089707">
        <property type="term" value="P:L-lysine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="362"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT67189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="766" mass="83323" checksum="2B681F432A41A125" modified="2013-09-18" version="1">MASPSRIPSEQPPRSASPSSFRPRSISASVPRADLTARLASPIPSQLLGTTPPRGGSPRPDAAPRAENLEDLSQLPGSGTSAQGPGVSALAAALSNSLGQSPPRHGTPAARVATPPIRSQSPLLGGRNSGTPTNYGSFNSRSQNALGTSAPYEDPEIVKRHLVQPSDENPGSEESSIQGNSKGKQPAEIGGAGLGEDEFSSLKLQGGDVTRGIYKWTEQAEARAKYNRSKSFDLGRPEPEAEVLDINSIKVPGGFRRNHLRRNVQSPGPHGHPEDGHASPAPGQQRLFTSSFLEFLTIYGHFAGEELEEDDEDLGPNEYFSSGEDTDEYNSDDEREPMEDSALLTPSRRRRKRKVRGGTGNNSPMNAALLLLKSFVGTGVLFLPRAYLNGGMLFSNLILFGVAALSYYCFVLLVQTQLKVGGSFGDLGGALYGKHMRTLILASIVISQIGFVAAYTVFTAANLQAFVRAVSDCKSSISIQWLILIQMLIFLPFALLRDIGKLAFTALVADAFILIGLAYLLYYDILTLNANGISDIIMFNKKDWTLFIGTAIFTFEGIGLIIPVQESMRHPQKFPRVLLIVMIIITVLFIGMGAISYAAYGSHTETVVLLNLPQDNKMVNGVQFLYSVAILLSTPLQIFPAIRIAETELFTRSGKYNPWVKWQKNVFRFFVVMLCAAIAWLGADHLDKFVALVGNFACIPLVFIYPPMLHYKAIARTKFWKVADILLCIFGFIAMAYATTLTAMSWATAEPKHPGYCDEKGTMVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXF8</accession>
    <name>S0DXF8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429302.1">
        <property type="nucleotide sequence ID" value="XM_023576099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXF8"/>
    <dbReference type="STRING" id="1279085.S0DXF8"/>
    <dbReference type="GeneID" id="35406870"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13416"/>
    <dbReference type="HOGENOM" id="CLU_568634_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="53907" checksum="B2A5D8B8EE691411" modified="2013-09-18" version="1">MTIHRPLREIRQQSIADGVVTNIGSLNYETPKTEVHKLLQDHDFSVEIYWPNFEPVLGESDLGTAIMGWCWVQFQRREDAQRAKDVLNGTILYGRRTKTGSVTHQPGPKSQKDSRGKGTSKSLPSRPATRATSKSFLPVSAAPTPSAIETPSSAVSFLTAHYPDDWIWDPAKPGMYRSAFEARTKHIQSDYASRGLVIGPDLTQRQDKTLSPLSQPVPSPHPCNKDVWLQTFIQVFERGGARTEIKKIPTTDLPKFQAQGYSQHFHPVKSSTNVFMTGMIASGLAVKVMPGEELVTTLPSKDLVELTMPMTEEEKQQVQQGKGPKYYWQPGRLTGANAAAEAGISDPSRAFFPPSEMDSRNRFATCSSHMQQHPRPAGVGVGWSGFDRFREWQLHGRQVKRDSVEYESFSKEPKSTLDFVTETGEVTMTIPMDIEEFKPEPSFLKTLTLWEKLNDGKGKQVRSCKTRKDRKDRYTGVRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXY4</accession>
    <name>S0DXY4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF974 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429396.1">
        <property type="nucleotide sequence ID" value="XM_023576211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXY4"/>
    <dbReference type="STRING" id="1279085.S0DXY4"/>
    <dbReference type="GeneID" id="35406971"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13517"/>
    <dbReference type="HOGENOM" id="CLU_027041_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="2">
        <location>
            <begin position="195"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34656" checksum="3BB0B614C24C105B" modified="2013-09-18" version="1">MSHQRYPSHDPVKEPHSISLKVLRLSRPSLVTQYPIDSPSSVGASIKSAPIPASLAYHSEAASNPSPFLLSPAVNLPVSFGSAYVGETFSCTLCANNELPIDAAKNIRDVRIEAEMKTPGMGAVQRLELGPLNDQSEVDLESRGTLQKVVSFDLKEEGNHVLAVTVSYYEATETSGRTRTFRKLYQFICKASLIVRTKVGPLNSNNTQEHGRWVLEAQLENCSEDVVQLEKVVLDTEPGLRYQDCNWEASGSEKPVLHPGEVEQVCFVVAEDGTESGVEVTPDGRIIFGSLGIGWRGEMGNRGYLATGKLGTRRAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY50</accession>
    <name>S0DY50_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SDS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein sds23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_13689</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in DNA replication and cell separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SDS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429555.1">
        <property type="nucleotide sequence ID" value="XM_023576402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY50"/>
    <dbReference type="STRING" id="1279085.S0DY50"/>
    <dbReference type="GeneID" id="35407143"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13689"/>
    <dbReference type="HOGENOM" id="CLU_024459_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016711">
        <property type="entry name" value="Ssd23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018148">
        <property type="entry name" value="UCP018148_CBS_YBR214w"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="231"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="305"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="419"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="502"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR018148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT67474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="540" mass="57602" checksum="3F07A880CDEAD9D7" modified="2013-09-18" version="1">MDPSPSSTSRELKDTRATSSTSLNSAASGSSSTHKPPTLSQRSPSVSISAGSGPSSISAHRASFAEGLRNAPSSPRSQRHPSFTQAALQELLNHPPAGNKHANPRFAGRDWRDVAIGELVSPDDVKWVEFDSSVEEATKDRRNMRLQVPNNHANSNSQLLLKSPTNVVLVREDPSTHIAVSTFDYTDLNAYLLVVVGLAKPEEDQVELFNSILAKAQEGGQIPLRDVFPLFRKETLITLPGDEKLAQAIQILGSGIHRLLVTTTSGEVVGIASQLRIVEFFWNEGVNFPSIDRLYPALLRDLGVGAKEIVSVNSDSPLSEALTLMNNEGLTSVAVVDNGMNVVGNISTKDVRHLTKSSNAHLLNSSCMNFISVILNERGVEHGRDVFPVFYVNPYSTLAHTVAKLVATRSHRMWVVESASPSPSAPATPLMGPQSFTTAGPPPPAAPVSAAAPPSPVPTAAVPASPVPTAAVPASAMAGARLSGRLTGVISLTDVLNMFAKSTGLHPSDPNEQRARRRRSSSSSVRPSLDSSRASIDFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY58</accession>
    <name>S0DY58_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_13686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429552.1">
        <property type="nucleotide sequence ID" value="XM_023576399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY58"/>
    <dbReference type="STRING" id="1279085.S0DY58"/>
    <dbReference type="GeneID" id="35407140"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13686"/>
    <dbReference type="HOGENOM" id="CLU_015846_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000059">
        <property type="entry name" value="Serine palmitoyl CoA transferase subunit LcbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="124"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT67471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="516" mass="57503" checksum="677B7C9DCCE56F74" modified="2013-09-18" version="1">MELDALQARVGEILEQAAVYFHKVPGSAVFMRYIQSSYQNDPVRSAIELVLLLFFIRYLLSPSYSTRKQNYIKLREEEIEELIDEWQPEPLVVEQTPFEVAEAERLPVLVGPTGPKTKLANGRTVTNLASYNFYNFNGNDQIKEKAIQVLRTYGVGPCGPPQFYGTQDVHMKTEADIAAYLGTEGCIVYAQSFSTISSVIPSFSKRGDVIIADRNVNFAIRKGLEQSRSTIRWYEHNDMDALEDAMKAVAREQANARKLTRRFVVTEGLFELSGDSIDLPRLVELKEKYKFRVILDETWSFGVLGRTGRGITEAQNVDPQQVDMIIGSLAGPLCAGGGFCAGPKDVVEHQRITSSAYTFSAALPAMLAVTASETLNLLQCNPEILAQSRENIKAMRAQLDPRSDWVYSPSDPENPIMLLVLKPEVVAARKLGLEDQERIFLDCVEETLANGVLITRTKTRPYAHAVKPKDGAWFAQPALRICVTSALSKKDIEKAGVTIRHAITKVMTRKTSTKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY93</accession>
    <name>S0DY93_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429595.1">
        <property type="nucleotide sequence ID" value="XM_023575747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY93"/>
    <dbReference type="STRING" id="1279085.S0DY93"/>
    <dbReference type="GeneID" id="35406557"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13102"/>
    <dbReference type="HOGENOM" id="CLU_021915_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="25"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="509" mass="55999" checksum="080E220570D95696" modified="2013-09-18" version="1">MASPELAIAKATLSATLFRADPTSLSRPEVDAFFPILTDALTKCSRPNVQKCKVWIIDKITPSAARTTALAKYFNALSKSLQDDGSRPSLKRRRLHLLYVLNDVLYHVVTRNDDFKFATAWEPVLPGMIASAAAFDNCPKHKQKIADLIRLWENQQYVKSGFAKKLEDALASGVAPQSAQEAQASNVSLKLAKEAPFTLPSFHGDSTVPWYDLPATTWLPHLTPNSTKPMFPDQIRPIQLAAGPADKVLVNAVQDLLGEVERIFSKEQKWNDEPGNDLNELGERVVLDEITGEVIGGDTYYERGQTGVVRAPDLAAILAVDHEVLHGPSISAEELPKTLGVEVFPAAEAGHIVPITIALQNDHAVPATAGVEVEVEAAKHDLSAQGTADHRRVHLHAFRTKRPKTVHIARLLFLSKRLQHLFFLSHHQETSLSHHLPQLATKVLGHHRRLLLIWHQAGSPPNAAMMGQMMGGWNVPPPPPPPHNGYQGRGRGNGYRGRGRGGYDRGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ21</accession>
    <name>S0DZ21_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to transcriptional activator Mut3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_14536</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429915.1">
        <property type="nucleotide sequence ID" value="XM_023576481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ21"/>
    <dbReference type="STRING" id="1279085.S0DZ21"/>
    <dbReference type="GeneID" id="35407917"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14536"/>
    <dbReference type="HOGENOM" id="CLU_011099_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT67834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="615" mass="68755" checksum="BE8668C20F40C6B0" modified="2013-09-18" version="1">METAQSSRRKACDYCVSRKIKCDGKPTCSNCSLYAVTCKTTVTSRRKATRNGGITPAPSSQSGTQPDRMAALEERLANIEALLTALGGRTLGAPPTQPGLDISLSDIDVSGSSNSWGISPIQTPLDIAQCQHTTISNAGSQLTKAASSDQLELAPLSEVLPLVDSYFRNYNSIIPLFEENTFMRMLLDWYSSSTKRSTVAWAAINVVLAINYRILEGKTVDDPAFSQTIRNARSAMSELMMQGQDLTGLQVLLGMVILFQGSSEVQLAIVLIGSVTRLAQSLRLNSKKALAGLSKSEQAHRTRLFWLAYIYDREMAQRSQCPYHQPDCETDVDLPEPNPEEDLGIIASSSDTIRFNYLRSCAKFAFIQGKAHDLLYSQKSHTLTPERRSRSIALIEELLKEWVDEIPPELHTTEGIDKTLSPLARDMMTNIWSRHIETRIKIHSIFTFEDTWINRVRRYLSPAVIDITDDIDGEVKRADLTPLPAGWGECVGNARVCLELISSTKLTEYILWLHTCTALPCLILIIVNMIEYPDHDLVTQDRKLLDSCFGVFDGVMKYLPKEPFDTILSISHQLDRRAKGQVYRTMLGKGDMSYQEDFQMSPSTAWALLDDIEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ55</accession>
    <name>S0DZ55_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429945.1">
        <property type="nucleotide sequence ID" value="XM_023576597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ55"/>
    <dbReference type="GeneID" id="35408020"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14640"/>
    <dbReference type="HOGENOM" id="CLU_1796553_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="158" mass="17573" checksum="EBAEE751061A0283" modified="2013-09-18" version="1">MRPDLYILWFAAASVPVSGRTIYSEELGSDLSANAAHPQSDRFGLEKRQFRQHRVRVNWIVTLAQATDLILNVFVQTDSNGRVSIVPEQVNLGWILSNPQATGGSNEYASMLSIVRPWGRATAQIFWNAVTGSWIGVVSDGVVNERGQEMQHSLNWCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZA7</accession>
    <name>S0DZA7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427894.1">
        <property type="nucleotide sequence ID" value="XM_023574563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZA7"/>
    <dbReference type="GeneID" id="35396271"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02789"/>
    <dbReference type="HOGENOM" id="CLU_106798_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="271" mass="30925" checksum="75A3528E2EAB16BB" modified="2013-09-18" version="1">MYSSQSPSFTAEFIKEEPGKPVPQKPVRRRGLNDQIKWVKAWMSKLPQGDEDWDNNRPSTLEDILRLRDRLTISHVESRRDMDWLTLLETYAAASKDFEGRETQLHCMVMVAACHVAHDQGCTINEVMDAMAKCVTGGSDTLRSKRFALPKCVQIGDELAKVLGPRAYELPLRVNSYFTFGQHFTVECFPILRRESAFAHRPNNKLPSDLLRIPNLVYELCDGKSTPNRKGPRARRCEGQGEIEVTDEVEGEVDGKPRQHLECRFERGYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZQ2</accession>
    <name>S0DZQ2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430129.1">
        <property type="nucleotide sequence ID" value="XM_023576986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZQ2"/>
    <dbReference type="GeneID" id="35400282"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06805"/>
    <dbReference type="HOGENOM" id="CLU_1960581_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="130" mass="14430" checksum="19FF5C39D02D9DCC" modified="2013-09-18" version="1">MSTRTSPVKITEYARPRGITALVFGGAVFSYLCLAGVTLISENNAIWQTIDSISPGSAETFRWIVKTGVPPLIVIHSIEAVAFDRTRLMPHGVPRWGLLWWKWVLSCWIEGIGCWQRFASVVNAKKAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0B0</accession>
    <name>S0E0B0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_13254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429153.1">
        <property type="nucleotide sequence ID" value="XM_023575919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0B0"/>
    <dbReference type="STRING" id="1279085.S0E0B0"/>
    <dbReference type="GeneID" id="35406708"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13254"/>
    <dbReference type="HOGENOM" id="CLU_079690_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF79">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="182" mass="19765" checksum="B52354CF4D3CCA3E" modified="2013-09-18" version="1">MDHGGMGGSGAACKVDMLWNWNTIDACFLASSWQIKNQGMMAATCIGVILLVILVEFFRRMGKEYDALLQRGFQRQATTHSVALAAAGCTGAVVPTSQTLTYRASPLQQFIRAFIHAATFAGAYIIMLLAMYFNGYVIISIFIGAGLGKFFCDWLVVRINVEDLTAPDDKAKGIEETTVCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0K5</accession>
    <name>S0E0K5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430474.1">
        <property type="nucleotide sequence ID" value="XM_023577396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0K5"/>
    <dbReference type="STRING" id="1279085.S0E0K5"/>
    <dbReference type="GeneID" id="35400650"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07173"/>
    <dbReference type="HOGENOM" id="CLU_029371_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="445" mass="50970" checksum="0C4CCE5D901F892D" modified="2013-09-18" version="1">MASLNMQNVPNELVAHILSFLDSESDLQRRIYFDPAKLTRPVSSGPNTPLKNASLVCRLWRSSVMKILFRYVVWPFWRFYKPVAQDIASQIELLDFIRRNNLSSSVDHFTILIDLPLGSGQNRYPDGQFWGILPPVSQQPETPMSWNLLWSVLNQEDRDAEGSDTRTEENRAQCFWDNNWLWHTIFDVIDPLRITMISSIDILASLLSRTVDLSSHWAFNSTYYVLSLSRPSRSIAESKRVQVLPSHISGPMNRIPCDLFHIRDWSSVLVNEGSFAPVYSTYEFFHYSAATLLPAIFDSSDPSFDALCANLHSLSYIATFPLSHHISDHLIPNCPPVEHLYVQLMPKNRDFWESSSLSRVNLSDLWLECDTSYALLVRQLLQTVPQPGWQKLKVFETGDTPAEGVWKMNTYDGHINGSNGWREDSEGVFVKDDIQSSDEQTMAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0T9</accession>
    <name>S0E0T9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to potassium channel beta subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430476.1">
        <property type="nucleotide sequence ID" value="XM_023577398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0T9"/>
    <dbReference type="STRING" id="1279085.S0E0T9"/>
    <dbReference type="GeneID" id="35400652"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07175"/>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="353" mass="39750" checksum="1D17CC60B3F0F985" modified="2013-09-18" version="1">MPLVTQNVKPRVILGLMTFGPPGSEQLDARIFDPETYNKALDLFQSKGYNEVDTARIYVGGKQEGWTGSQTNWKERGLTVDTKVKYPAQPGENTYDKVIESVETSLKELGTDCIDLLYLHRPDRGTPFQETLGAINKLHKDGKFVKFGISNFTAYEVAEVVMICKYNNWVRPTVYQGMYNCLTRSIEAELFVACRRYGLDIVVYNPIAGGLLSGKIKSMDIKPESGRFSDQSKIGTAYRQRYFRESTFKALKAIEEATEKNGLSMLETALRWIIHHSGLKVTNGNDGIIIGMSNIQQLEQNLELVEKGPLPDEVVKALDQAWLYSKADTANYWHGDLEYTYDVHEALFGASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E187</accession>
    <name>S0E187_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to dnaJ-like proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13653</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429523.1">
        <property type="nucleotide sequence ID" value="XM_023576363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E187"/>
    <dbReference type="STRING" id="1279085.S0E187"/>
    <dbReference type="GeneID" id="35407107"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13653"/>
    <dbReference type="HOGENOM" id="CLU_009539_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000046">
        <property type="entry name" value="dnaJ homolog subfamily C member 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="490"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="529" mass="58897" checksum="A8F62313C955479C" modified="2013-09-18" version="1">MGAQQSSETSNAGGPAPVAKTCYYELLSVERSATDDEIKRAYRRKALELHPDRNINDVETATRRFAEVQTAYEILSDPQERAWYDSHRDAILSGRDGDDDGQSTTFRNVRLTSAEEIMGLIRKFNAAVPFDDEPTGFYGICRETFEHLAMEEEAAADHDDLNVRNYTTFGSSDDDYEDVVKPFYTAWTGFTTVKSFAWKDKYRLSDAPDRRVRRLMEKENKKMREDAIREFNDAVNFLVGFVRKRDPRYLPNSQTQDERQASLRNAAAAQAARSRAANQERMASFEVPEWAQARSDDNGAEGGFSESEEESEVEILECVICDKSFKSEKQLEAHEKSKKHIKAVQQMRRQMKREGAELELDGVSSPYETNANKQTDAAAQKDDVKEESLGSTQGGIVSPSPAESSLAATPAESADASDDTDYAPRDIVEERIASASKLKTTSDVTNEDDELSVSVQDLSVGEPAQGKKVGKAKAKRAKKAAAAQSQKEEPQCGVCGETFASRTRLFVHIREEGHAELKSVTGGGKKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1H4</accession>
    <name>S0E1H4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_07523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430794.1">
        <property type="nucleotide sequence ID" value="XM_023577786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1H4"/>
    <dbReference type="GeneID" id="35401000"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07523"/>
    <dbReference type="HOGENOM" id="CLU_2512802_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="85" mass="9502" checksum="2C220C45339AFF96" modified="2013-09-18" version="1">MAMRPDIEEVRLSVLEMVGVYDSPSFFTSSPDTPTMRFDPDVPASPALDEAMWVFGSALHLPAALPRYTCEWSYFPGSQCEEQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2C7</accession>
    <name>S0E2C7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to microbial serine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428904.1">
        <property type="nucleotide sequence ID" value="XM_023575621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2C7"/>
    <dbReference type="STRING" id="1279085.S0E2C7"/>
    <dbReference type="GeneID" id="35406445"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12989"/>
    <dbReference type="HOGENOM" id="CLU_006016_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07491">
        <property type="entry name" value="Peptidases_S8_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="679"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="684"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="728"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT66823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113597" checksum="E0FE1C5A39FDA45D" modified="2013-09-18" version="1">MNHSDEATNGFSQAHEEDDDEVYLDEDEFPAASVTLLDEDPVKAKFERHVEEARILSNNLQSSESSDKASQQLKFVNDRFSEWHNTTEEGKNFLHFLADYDHRIHKPPVNLQWLMWRAIRKLPAHLLWSPDNNKRIPLTSALLANNSLFGWSVCLKIKDTTCQEYNALLQKRYENRDESSETTCLHAAATCIFDNGVKRTEFFTKVCGFVPRDMFFVRDTKRRTALHRAVEYECCCNSQVEVVKEILRSCPDLLEEPIQDPDDFNRTLSVYQYHHLTRKKFLESRRRRAQDLAVQEPAAAAPKRVEYKLERGVDPKKDAKRVVTRTEKSGSEKTSMGPPPGVKRRGSIAATPQGATTPVQSPSLTPITRVKTGTATRPDIVQKPGSKEKEMEDAARTIGNLLKLETLRKLSPERAADSLRLPDDPDKEFWFDFGPPNTVSQDDFKKYFGHLQFDTALQYVGFPRVRLKGGREQPDVRHQGRKDMTFFFDWLRGKSVTRIIKVVVEDMEKPSHSDEAIEECLKDLGVEILDWRRLDLDALTLRKIGTHLREVHLQWSGSNSTLRAWSEKEGLASIPTLEVIHLFQHEGLESRERTIENLNAFEKRLHDSWPEGRPKPQVIPPKTGGGVRMATVQVPDARPQPLQRSIDPHKWMECMTSFSKRFKQIKALRGNNPSLPPVEVALIDDGVDIMHPDLNDTRDRTFLGQSFDHQTGGSTPRVPPYWSSPSGHGTLMARLIHKICPSAIIHVIKLQTFWSGNSKKLQIKPDSAVKAINYAAKRGSQIICMSWTIKPPEEPLRSQFDTAIFNAIGKHGCLIFCAASDQGQSADVSYPHASSHHCFRIGAAKATGNIVDTVGDSQTVDFIFPGHEVVIDNNETKTQLEKFDAHSGSSVANGLAAGLAALVIECVRLGALYTREYRKLEPKVAINYSHISIDEEDLKKIRSRAQMAYALNWIGTNQNTNNKYIEVWHTFSAVAEKLSRSEGVSLEQLEHIATLAGFFLKKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2E4</accession>
    <name>S0E2E4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_13009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428924.1">
        <property type="nucleotide sequence ID" value="XM_023575644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2E4"/>
    <dbReference type="STRING" id="1279085.S0E2E4"/>
    <dbReference type="GeneID" id="35406465"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13009"/>
    <dbReference type="HOGENOM" id="CLU_007383_12_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31027" checksum="9E1E24D88AE7A4B1" modified="2013-09-18" version="1">MSRNILITGAAGYIGGSIVVDLLSKHPEITKDQIVAATSGLSAFYANSGWSCSVNKDTDAVFETEKGVADSYPVRKTDVMVIEHAQAQGVTPFAVVPSIVYGRGTGAWNQLSVMIPGLTRASLKLEKVYKLDENISLQAVHISDLTALYCRIIHAVLNHEEIPSGKEEYYFAVAHDMDMWEFQDHLAAAMKARGLVTSDKPEVYPSNEFDADSIDVPLEFLEDLYKSGGHFTATRPQSVGWKPQWDSERFLKNLDGEIEDVLELGKAKSSLIGTLFAAVGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2H9</accession>
    <name>S0E2H9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429948.1">
        <property type="nucleotide sequence ID" value="XM_023576603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2H9"/>
    <dbReference type="STRING" id="1279085.S0E2H9"/>
    <dbReference type="GeneID" id="35408026"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14646"/>
    <dbReference type="HOGENOM" id="CLU_035514_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="561" mass="62894" checksum="C27F6C0F94503BFE" modified="2013-09-18" version="1">MLALCRVSKAFNLMTMEAILESDMLDDVGYWDPVRKQTIFYHTVDDDHRSSYPPLLENVSDDGDTNSEPETPDLDRPVSPSLAEGNQEKSEDDTLSGEAVITSSSSVVPSDDFWVMFLTARTLGRIRTKPPTQDHVLLLKVSEYLYQHIQQTSSQIELEDTVRIVCEVAVKHGYIYSHPDFYIKTGSSAFDATALQLDESCAVFRDALAAMAVHLSDNTLLENTLSNKDQILCPSHLKALSTADEQLTALSSFQTPIPQAGRILDDELGLLPPKCGKSLIRLANPVKLAVQLNKIEYIHLLLKSVSTRERELDVYRTDIVTEVILPDQIEFLRVAIESGWPLTRYRLLAPSIADMIWMNGRTDLSSRSPAGIRLSKILETTIDLDVFNLVYDAILEGYNDNEGVWWTKGLSFAADTLAFWGLRRLQRAVLDDCLPIVRRLIELGYSLGPTRTIEDLEGEEQNVVAEIINGERTVDVALPVAAGRGNLEMVRLLVMAGAHRKRKNVRKAMRIALEQGNHEMLEVLASQGSPAGLLNRKAKQRWKKDSESSGRQNMLKWIEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3Z1</accession>
    <name>S0E3Z1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable SnodProt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_07171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430472.1">
        <property type="nucleotide sequence ID" value="XM_023577393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3Z1"/>
    <dbReference type="SMR" id="S0E3Z1"/>
    <dbReference type="GeneID" id="35400648"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07171"/>
    <dbReference type="HOGENOM" id="CLU_111635_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485270" evidence="4">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT68392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="139" mass="14623" checksum="E0750E7FCBB8E620" modified="2013-09-18" version="1">MKLSGVLSALALTSAVSATTVSYDTGYDDKSRPMTAVSCSDGKNGLITKYGWKTQGNVPTKYVGGVNIIEGWNSANCGGCYRLEYKGKKINVLAIDHAASGFNIGLDAMNALTNGQAVKLGRINAQVYHAKPSDCGLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E402</accession>
    <name>S0E402_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431629.1">
        <property type="nucleotide sequence ID" value="XM_023578655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E402"/>
    <dbReference type="STRING" id="1279085.S0E402"/>
    <dbReference type="GeneID" id="35398923"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05444"/>
    <dbReference type="HOGENOM" id="CLU_560256_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="487" mass="55438" checksum="8241AEFEB6A75B42" modified="2013-09-18" version="1">MDAVRFAKPAITSIVPPELLGDIFSRLCSHCSDDVDSEDNAANTKDLLALTQTCRYFRSVAMPILFHSLGPHLPSTYIFRVLDDQPDLVHMVKHLCLPLSTPKSSSIMADPVVLARFANRLSLSREWIERTQFSVVDAEMCLAMALCSGIERLKIQIADDQIFGHPRHFEILYSLLENRKHEDIFPKLRHLDIDKTQCIQFSLCDPEPILLLRGAPRLRTLIFRGPATERHGNQNSESNIQEFCAGVANIAEIQILGWPFFTDNWQTRALERILGAARNLKTFKFVGVGSGYWHTDARSEISPAQLLGFLSPETEKTLQHLSLNFDSRSVPSRLGFSQPEPIRPQQIKQFTSLNTLEVDPLCYCIQDNGEEDDIEQETYLVDFLPQTVHTLTILLDRWARYGLVYDSTLLAQRVLSGEFPNLKRVQVDAPIWCMMPLRNSGDDDWDKEQQVKLSDMKVRGEAFEERFVGCGIETRFKTWVVQLDGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E568</accession>
    <name>S0E568_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_14781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429844.1">
        <property type="nucleotide sequence ID" value="XM_023576764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E568"/>
    <dbReference type="STRING" id="1279085.S0E568"/>
    <dbReference type="GeneID" id="35408160"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14781"/>
    <dbReference type="HOGENOM" id="CLU_032067_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT67763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="488" mass="54560" checksum="BE47AB8406FF21CA" modified="2013-09-18" version="1">MAPQSEEPNTFDVIIIGAGISGINAAYRLQTEGPSDLTYAILEGRDSIGGTWDLFKYPGIRSDSDIFTFGFPWSPWKHDQSLAPGDKIKDYMIESARSTGIDHHICYKHSVSEANWSSKERRWQLQVTRPGDEKPVTFRSRFLLLGTGYYDYQTPLQTVIPGIEKFQGKVIHPQFWPEDYDYTNKEVVIIGSGATAVTILPSMSDKAKRVTMLQRSPGYIFPLPSSSFFTRLLLTVFPASIALFLNRLLWLVRSYLTNVFCKSCPGLAKKLIKYVTIKNLPPDVSWDPHFKPRYNPWEQRFCASQDGDFFAAIRSGKANVVTDKIKTITEKSIELESGASLHPDLIVTATGLKVRFGGGIKFSVDDVPFNVADKFAWKTVMLQDVPNLLFMFGYENASWTLGADVSARLFVRILKKMTQSKTSVVVPRLSSSSGMPVKPMMSLSSTYLKTASSVFPKGGTGLWSPKSNYFVDMAGARWGDISTGLEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5Q3</accession>
    <name>S0E5Q3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of G protein signaling superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432318.1">
        <property type="nucleotide sequence ID" value="XM_023579489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5Q3"/>
    <dbReference type="STRING" id="1279085.S0E5Q3"/>
    <dbReference type="GeneID" id="35399668"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06191"/>
    <dbReference type="HOGENOM" id="CLU_041181_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49847" checksum="23BE0CCBF5AF0D81" modified="2013-09-18" version="1">MGLLSLSYTRPKYVSRQSFRNNTSSDSLSDAEKSDATDNSSSSRSSTGIPDSLSFDRIIGGGTCPPMTLRDLMTYLIYVEHAAENLQFYLWFQDYEKRFNANPTPDLKLAPEWTRAMQDEAVIKIRKEQSDKMRKEPEAAAIFKGSDFEKKAGSQDRNMSAVDPFATPPQSSKGDDSSIYTASCTMNSLNAMSHQSQASDAFNMAGAQQPFTIQPFREEINRVISTYIMEGAPRQLNLSSSEQKAVIVALSKTTHPSAFRSVFKTVDSSLRHQAHPNFIRWSICNGNPARVFFARSLGVGLIAAGIVAGIILTLSNAGRGYRALAAVALVLGISTLVAAYKGMCVVLHGMHHRHVRPWELFVDSENVEDTQKQSFDSFGSKNSYEDEPWVVKYEKRNVVRKVFDREIWIQEPALRQIQDTIFVQAILASVLLGGIITAIFVAVPGGHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6X6</accession>
    <name>S0E6X6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432728.1">
        <property type="nucleotide sequence ID" value="XM_023579986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6X6"/>
    <dbReference type="STRING" id="1279085.S0E6X6"/>
    <dbReference type="GeneID" id="35400115"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06638"/>
    <dbReference type="HOGENOM" id="CLU_069189_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024653">
        <property type="entry name" value="Peptidase_M10/M27/M57"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12388">
        <property type="entry name" value="Peptidase_M57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27789" checksum="30E276A63275DF4A" modified="2013-09-18" version="1">MAAVAEITKYPCNTQEETDPSFGPAPISNLAGTTGDNAPDEPDSLVVGFGTIVPRWDVKPNGGRKLEYFVQTQSFPSPDTARTAATAFQEAADSWNELNIGISIIETTEQASANFYLVYRVNPSFGNGRNTLARAFFPHEIDQDVIVFTRAFDRNNLPILKNIFQHEIGHILGLRHEFAIEGDAAKDLLPEGQGAVLLGEKNYFSIMSYNFPPKFQDSDGNQTIGFYNLANGHMISGSPVTDFQPQIRRANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6Z8</accession>
    <name>S0E6Z8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432670.1">
        <property type="nucleotide sequence ID" value="XM_023579918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6Z8"/>
    <dbReference type="STRING" id="1279085.S0E6Z8"/>
    <dbReference type="GeneID" id="35400054"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06577"/>
    <dbReference type="HOGENOM" id="CLU_013539_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="783" mass="85727" checksum="608566611FC39EF4" modified="2013-09-18" version="1">MASSRADSDQSAPLLSQDLQLSNAVGFQQQGTVDWTRVLSGSVAFSVDVLSRLSKAGIEAFTIYAARAIFSNVKIGPNGELRLHRALDKISAFPSFGKALWFGFGVKHIIWSMQESTEGLNCLGICACLTEGFSTTVAAKIIRELFLLYDPPAEVTPALRQWIALVESSAGLLASSEFGLVLHGLTKLCLMDGQRNVRSSGSPKDIALVLKEIFEVSTGRLDRLFLSGGADCAWIAAVAHWLLDLRVEVQHQDGTVIYRPDGARSEFSLDAQVIIVYHQGDSSELLRVNSKHHIIPSGNMLIHYHEPQDIMSYGRLSWDSCLVDTFGGPMRLLLGPQARSTGACLGSAARVFLAAMRDGDGHMEFLAKRDPRNSFPPVSESSYGRGFYLLARRLFPELGQNPVLHQTMEAALNKGFLEAAQLFSQSFTSLRQLCSCSICRPGEGNEREDNTFCLLTLIQTICTLVRAMSSICMEEGLEVRPTRSGLENLYWTQRNMLITRELLEYDPINHGLLSSWPPGGVLMVAQTLLSGQQHDIVSGSGSLVAASHHGLCFLLNTLTEITSDPQRAYVVIVIPGRIEWNNFMYDTVRDQGFEMVNTPEKTGYDAISMSTVTRYDDLADSSTPGLNAELLIEEILRENTSLHASYRISTAAFPGRHFSVGPSDIWHNLNSAVTSANCEGKACESLNGFESTLVEGDGLLPLTDLPTLLPPITRVLSTPGLSVWVALSQSYLPKTADPMRGGLVTLQHRLQGKQCVRCCIVNAEQSVVNCQPPRCCISILTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E704</accession>
    <name>S0E704_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431597.1">
        <property type="nucleotide sequence ID" value="XM_023578616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E704"/>
    <dbReference type="STRING" id="1279085.S0E704"/>
    <dbReference type="GeneID" id="35398888"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05409"/>
    <dbReference type="HOGENOM" id="CLU_434147_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="427"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="630" mass="70225" checksum="1E4A1EE7C11A4E53" modified="2013-09-18" version="1">MAHNDIEPVAKLGLSLASSLQVHSEANRRARQRLPKLINLINSTALTLIKVDDVIQENALTKLCLEDVTRLTATCEKVYIGILIMLVRQTESFVGDKEINEIPREETGKYLQSIAHINVWRYESWESLEVQLGYFRYRLTQIKLELMLRYLLGSVAQHQMRAQTRVPGSFETENAIRQLAGQVAYKRASHYKFWSKKVDKWTIIAPPLASSNVSTTDVNSTCSVSSTPTIAVDTKIEETKPVETIPPAETQSPELSKDTEVLADTTAETTSTPTQKDQQPAKEPGPSLLTATRDWIKRIVMPGSHDEWKNQDLEVWQIDLAAHFNCAPTKTFKRLELDDKHVRSALSKATSKSRWRKCPGLLEQYDSLDQRVRQRIDDGIDAAKQSSCRERTWIAMSTASPPLKNRYEAVVQTDASICLFFRLGDEVEPIHVVELHTGKRLTFPYASCKDLDSLRKRLSCLTLGYPASAILKDGKYNFCAEDGTVILPESWESLRRPGMTLNIQNYGTPIPPVFGGPTPFNRRPGMMPPGPSNVVTVGPPCTSTTTSSSSSTRSYTSLTMKQVHGEIEEMLHLSDSWSPDPNTMGTGLGRLLGLWTNALDPHVNATEDSDSEWSCSASDSDYCSNGSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E707</accession>
    <name>S0E707_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7600 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432534.1">
        <property type="nucleotide sequence ID" value="XM_023579755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E707"/>
    <dbReference type="STRING" id="1279085.S0E707"/>
    <dbReference type="GeneID" id="35399908"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06431"/>
    <dbReference type="HOGENOM" id="CLU_012355_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7600" evidence="2">
        <location>
            <begin position="321"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="775" mass="86764" checksum="1B95C0DFC06581FF" modified="2013-09-18" version="1">MIYCTLCGIHITAQTGETWLQEFRAIWVESDLVDHVAVSGVGRRSNNDDEFFGTAPDDPKKRYDDDTGPGTTIDVALTPSRPTIFTRSLDEDVSAWGYGFHASCWSIFTKYSTPNLGHLFAACLSMPTGQEAFLNWGHDYGGASILEKGFEVPTQDTRFPDPRTIPNPFRSDPFHIPALANAIQQTARLQNDIFLSHVTFNTKALTKDPFFRLSPDILQLITVLLSTSEIHAIRLASPVFASLQLTERFWASRFQPGHEFEYIPEVIDHPPESWRAFYSSLQIWALNDPHMANRKRIWSLAKTVHGLVSQMEDIPCQGRPLQTWFETSADLDDTSACWHTAACASTQPNDSFLNGNRVLRARILSFSPTLMMHRMSVSFVNLPEGVFVSGLVLINHSHERYVIGYIHEGNMVDIHLPNAQHIQGWELALHTSGVKAMALIYEDGVLSSWAGDPAGTPRWRLAGAPGLLAIKAEFDAIKLVKLSRQGSLDELSWRNNCLWYPQVPPMGLLYDWNRGDKPPSEFKLPFTRVFFGEADDMYSSILTEIVVWIFDVCYISGMEFRFANPSHNRQLGNTGPFDEEFPGRRNFSDSHDSNVSLIIDGGAGERLKSLEVQERGATVVGMKINTTFNRHVQTPGYPYGIQKGWVTVQPKGSRIVGMFATCRRGLLGDGFNIACGASSVQLMEEEGMQRIQHPRTGGSCPVRGNANESFDLNQRANCSEVDRCHHRAALPCVFSMVDLDLDRSRRIGNAQQGESEFKLRISGQRSSLPACLIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E734</accession>
    <name>S0E734_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431612.1">
        <property type="nucleotide sequence ID" value="XM_023578633.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E734"/>
    <dbReference type="GeneID" id="35398903"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05424"/>
    <dbReference type="HOGENOM" id="CLU_273423_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="169"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1294"/>
            <end position="1327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1365" mass="154164" checksum="48071CD3E2A09543" modified="2013-09-18" version="1">MEVVGVVAAVPGLIQIIQAVITAVRGVSKKDVAPKVAQNLIQSLQNVEQILERGKEQGLWTKPQFEQHKSTIKQWTTELVSLKLVLQPSNIKKETRRSLKKFYLVLTELEKTLNEWSTRLSHIQTELVLIMTHIQQEIMKDVLHETVTSRLRADLHPCSDSFIPDKSPGTCEWIWSQTTLSDWVKSSPTMPDSYLKRTLCIHGMKGCGKSVLIKSIAQKLGDQGQIALHFSFWSGDENQRKLQDLLRTLVWQTLRRIKDADLEKVSKLLTRSDGIDKRSLVEALRIALSGISQKVYCTIDGIDESSEDWNCSTDGCLSTVLDLVKDHTNLHVLLAGREASLRTFLKRAGPRLEITEHLIRGDIEKLIAAEIHDSLKSYSQAIRDEAQKSLEAKTQVMFLWVTLVLKELRRCSSVEDVRQTLQQVPHDLDREYHRLLLQLMIRTKGSLAKPSISMKRARCVLSSILACPEPMTGEDLCYAYATQANMNGTIEDDLITIDGIMDACGDFVRLTEGRYHTIHASATDFLIRPKNEWESEDANISYFQVDLAEAQESMSLACFKYIKSIDLGYPLTDGGAPSLPSKYIFFPYVARYLPFHLAAALQESEQVRIETSKFVKTHHFCALIEFLLATSENSLPNDFLGSMYYWGEIFARMWMELDQAFHLELDRRERDFGDQDERYQSWLALAFLIPESAQKVPEQQARPLKRFARHRSVFAEMKGNGISFLPRHIGNTHGPIIQRVSGSLQALSQIFATFRSTGTDLLAASAESMPVPMLLLAGRVARQQGNPLLAEKIAIISVKKTNGKGGIFELCSLLLLVAVRFYSNQDTSEVTVEMVRKSVLIADRLPTLPHIQMLKVEALQILILILLQHERKVEADEFIRMYEDLIGRYRKESSSRVWEYGLCHTRIGTASRTDALEYMARKLLYTGNYTVSADFSAQAVGILADSGSKPTSKDLSLLAINRDSLYKAGKLDECISSCQQLLDHSTKLSSEPIVTDARWQTQILVARCLAMAVDTAEADMWFRKATDEIALLGPDQRHQKRQSWFLFMMEDVALMGQYRLAQSMARELLEIKRVPPSDDEEDLGFGPLESLVSKLKDINSIDPSYLEFLRCHSLLITAQGVRDMAGRVDWFGRRLCSIYDDLESFSKRLPLLKLKYIDTCLRLDDGLFNAIGGYIMLGRFFFNQGNTEAADIVSSDAASRIFSDMSSDDPSWTFRLASQVYLFAGKFAKCIPLLCQAYEESLNVNGDAVFSFEMEMVYAFTYILGLEEFEEDLEKVDLRLSFLEKSCEHVAKASRARDEIDRSKGSGSQEEPRDGDHDAEESRKERMADLKARLEDLNVGSMLTEAVARLGSVAPGAEVLSENNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7S8</accession>
    <name>S0E7S8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-methylcytosine G/T mismatch-specific DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432789.1">
        <property type="nucleotide sequence ID" value="XM_023578943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7S8"/>
    <dbReference type="STRING" id="1279085.S0E7S8"/>
    <dbReference type="GeneID" id="35399181"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05702"/>
    <dbReference type="HOGENOM" id="CLU_008691_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF5">
        <property type="entry name" value="5-METHYLCYTOSINE G_T MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="840"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="871"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="894"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT70710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="917" mass="102067" checksum="2396EB79BC3F5B0F" modified="2013-09-18" version="1">MSSKDHDLEVPADEPPREKPRRSKSERKDHKDRDRDHDREKHKDPDRERRRHRTSRSSRSKLSEVSDTVSHTSSRRHRHRRERDSDEQHHRHHRAASTSDLASSDMARTSTAATSILSDRISVPYPSFSKAHSKEAIVSRDSLSLPRQRSPKPSTPEPTAAPYTEDSRSPKGSDSGKPDVPLSPPRTDLDADKTAVNEETPEDPAKEEYSKEEAPENETPKVETPREETPRIRTPTEELPAAEAGLEQPKSRVSSLSRSASRNEERSRVSRRSGVSSQATYVKSSSRRSGDKVRRSDSRASSSSHRSVHRTSSTRSHRRYDVDGASSPSSAQDSSPRTPTQAPFPHGYPDAKPETPSVIDVQDVDSNLHSKTATPASAFGAAPPPPPPPPPPALDVHDMPRVDYLLQNGGLAYTAPKNFLSVLPRQNGNRPSNPPLVGTDTLFAPFHNLLDQYNTVLSKQGSIAVATGHRSVARRLLDRLENVFSRDLPPHGCTCIMCDSPHEIHDGLNWGDVLEWVSGRIDLPQWPPFDLAEVGTKAAEISGDRPPRPQSPVQLDPDIAEEFREHYLRQSKKVRSAVDRWLSNTGETPVPPPQDVDDETLSFAILTNLDPEDRPYFNAIMTGSKELKSSVRAPTPGHRPRTDFLIKTGLALQRLYRLQQVPRDAESATYLVKNPHTHDLLVALSNINNSEWEILISGRFDGFLWSGADDDVPQTPHNESRGPTPASAYYNTRTMSPGPRASSSFSSRNTTPFSVYSRGTTPASFVSVNTTGMPGSRQAVSNDEEMEMAAIAEIEREIYKGMETLEDAFEKLHKKAEVVRNALRQRGAALMQNLQNRRRIDVLSGPNSGNSQASGYERPAWAGESDRDPGSDDDWAFDDVDIMPDDSASNISSSRHRRPKRRTERRTPAPINEEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E864</accession>
    <name>S0E864_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433158.1">
        <property type="nucleotide sequence ID" value="XM_023580372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E864"/>
    <dbReference type="STRING" id="1279085.S0E864"/>
    <dbReference type="GeneID" id="35402353"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08878"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_20_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="211"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="787" mass="89602" checksum="EB26B33B267786D7" modified="2013-09-18" version="1">MADPLSIGASVLAFIGLADRIIRTCRYCIEAVEDAPKDIQMVLGEATSLRAIIDSIGESSATSLVPNLHEQNGPIKSCHSCLASLEALLPDTIGQYKTGKRRKLTLVDLAWPLKQSKVRKLLAEISHHKATLLLAMSGDMSRDLKEIKTGIERLQGTISESEARETIRWLERINPSSLHNIAFSKHEPLTTAWVKNSSQWKAWVSSASETRLIWIHGLPGAGKTVLASYVIEELEKLCEPANGSVCSYYYCHYSHNQDETVPLMSWVIAHICRQINWIPTELKRLHGHGCEPTIVDLGVVLEVVLQRLDSLYIVIDAVDESTPREELLSLIETLTVDKRFEKIRILATSRQYFDIERSLGEISERISMSNTMVDADIRRFVHARLRSSHRLKRWHERFDEIEEALATMAKGMFRWAECQIQAIERLRDQSKLQQLLSNLPKDLSETYVRIFRAIPQDERPLVRRVLTWIIGHSQAAWLYDVGVNANLLLSAVTYEHFGYEIEGQNSIIDFEYLQEICSCLITVRYVPGDIFDSQHEDSTGLQAREATGGQDLYVSLAHYTVLEFLVSPHVFQPNFAFFAMSPELIRLKFAKSVLKQALAADPEGTNTDWIHDREAYCLTLGCALYIHDILADSDLQDLFLRYINPCSPHYSRFEAIQSKIVQSDENSSCYFLRHIPARFHCSATKDTCFGSAAALMNLLLLRHQSIQKGLMPMIRRLLEGRPVQELLNVRVTATFLDEADKDLDENGSRLCQNTLNGMVWEIVQWRQTFLDDEELAESFDMLWRHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9K5</accession>
    <name>S0E9K5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_08378</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433618.1">
        <property type="nucleotide sequence ID" value="XM_023580929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9K5"/>
    <dbReference type="STRING" id="1279085.S0E9K5"/>
    <dbReference type="GeneID" id="35401854"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08378"/>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019280">
        <property type="term" value="P:L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="18">
        <location>
            <begin position="4"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="17">
        <location>
            <begin position="435"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="385"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="524"/>
            <end position="525"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="662"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="736"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT71539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="766" mass="86630" checksum="CD05C54AF451C385" modified="2013-09-18" version="1">MVQSAILGFPRMGVNRDLKKATEAYWGGKISQSDLLAEAKRLRLAHWKIQQDAGVDIIPSNDFALYDQVLHQIQDFGAVPERYTKDGLDPIDQYFAMGRGHQKEGVDVPSLEMVKWFDSNYHYVKPTLQDNQTFKLTDSPKAVAEFKEAKDAGINTRPVLVGPVSFLHLGKADRGQSVEPIDLLEKLLPVYEQILTQLKEAGAETVQIDEPVLVFDLPQKTKDAFKPAYEKFASLGDKIPKIVFTTYFGDIVHNLDLLPKDVYGVHIDLVRNPEQLEKVLDALGSNTILSAGVVDGRNIWKTNLKRAIETVETAIQKLGKDRVIAATSSSLLHTPHTLASEKKLDPEIADWFSFATEKASEIALIAKAVTEGPASVREQLEANAKSIKARADSPRTNDPQVKERQSKVTQKDYERKSEFTTRISQQQKKLNLPLFPTTTIGSFPQTKEIRVQRNKFTKGEITAEEYDRFIEKEIEENIKIQEELDLDVFVHGEPERNDMVQFFGERFQGYAFTTHAWVQSYGSRCVRPPIIVGDISRPQPMTVKESKYAVSVSKKPMKGMLTGPVTCLRWSFPRDDVHQSVQAEQLALALRDEVVDLEKAGIDVIQVDEPALREGLPLRSGEERDAYLKWAVQAFRLSTAGVEDATQIHSHFCYSEFQDFFHAIAALDADVLSIENSKSDAKLLRVFVDSEYPRHIGPGVYDIHSPRVPSEQEIKDRIEEMLQFLKPEQLWIDPDCGLKTRQWKETKEALANMVNAAKYFRAKYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBZ7</accession>
    <name>S0EBZ7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434549.1">
        <property type="nucleotide sequence ID" value="XM_023581942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBZ7"/>
    <dbReference type="STRING" id="1279085.S0EBZ7"/>
    <dbReference type="GeneID" id="35405802"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12346"/>
    <dbReference type="HOGENOM" id="CLU_049925_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36614" checksum="337C34776ADF57CA" modified="2013-09-18" version="1">MAQTVTKTAQHAFRQGYLVNDGILESSMIGKLKQSYPSEPIEHLRARYEKDGYLFMKGLLPRSDVLGCREAYFRFLSPSGVLQPNSAAVDGIFDPNNKGVNYPSIGASPFGKDQINPGSFASLAEKAHTEDFYLDFSRHPALRDFVSGLKGWGDNTKLLPRSLLRNNTPHNNAIGVHYDQSFLRYGEPTSVTAWVPIGDISRQGGGLIYLEGSDTLGRTLEDAFNKKAREGGMSEEERIDAFNKNMMSNGFLELGPIKFLQDNGGGRWLLTEYEAGDVVFHKPHMIHASTINKDPENRIRLGTDLRFVDSSRPHDTRWSAPFRLDDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC57</accession>
    <name>S0EC57_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to protein yhhW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_05908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432057.1">
        <property type="nucleotide sequence ID" value="XM_023579173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC57"/>
    <dbReference type="GeneID" id="35399386"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05908"/>
    <dbReference type="HOGENOM" id="CLU_064194_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212:SF3">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="92"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT69978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="325" mass="36134" checksum="511CF10CE30842CB" modified="2013-09-18" version="1">MFRVSPLIAIFVAAISILIIIYPSNYIAHIQQLTTNIFTNKTTTITSTTQSQMNAAKNMSKSLRHAKITPHRSNSRGHSDHGCHFGSLRVLNEDRVKANSGFPTHPHRDFEIFSYILSGELTHRDSMLTKGKEGGQSDKFYRMHRGDVQFTTGGTGIAHSEFNEHKSDTVHFLQIWAIPWKRGLTPRYHTRHFSDESKRQDFVKILSPLKGGEEATVQQEKDAEPVIPDTIPIHADFVMAAGIIEPSKKFEWTVGGGATEQTKRKVYVHVPMTKGGRAKIRLDGREDSEIQEGDGAFIDGVNAGDKLAVESIGEAEAEVVVLDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECJ4</accession>
    <name>S0ECJ4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432172.1">
        <property type="nucleotide sequence ID" value="XM_023579313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECJ4"/>
    <dbReference type="STRING" id="1279085.S0ECJ4"/>
    <dbReference type="GeneID" id="35399512"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06034"/>
    <dbReference type="HOGENOM" id="CLU_019274_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="231"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="578" mass="62576" checksum="457D4E29361AFA3D" modified="2013-09-18" version="1">MPCFKGIAVSIHANSAPLPEYGMQKQSRLSRISTYIPVPQPQLAESNKPEPAKFAISITLLTPGLPIPYSTPKPSDDNPYPKPQFVGGLNTGDRNKSSGVVNPYIPMTNSENETIAAYIYFDGRAKEEVATLLRPGEETWVNSRWVQVPDSEGGGLAEREFLFREVGLERWLNGLDLQGHDAAEKLEKRRQKFEKRRRRQRAMEGNASADVEQGSTGRRDTLRYGADDKSPIEAVVDDSDSWSDDDDEPPEATGQIKVAMFRVLASGEIKKGEYSPQFGAHDGDEDDMGSKEGNGIDADVEHTTSFAKPKTLDPKTISTQTVTGIDGPDKPYAVFTFFYRGERQLQKIGVLQSSKNPQTTPGSAKRRSGQLDFSSLGPLKAGGTVGFSAFRDQATEASRRRKARKKSNGNIADDSDDDDEEDDENLGKMEEVYAKDVNAKLAPEDVKFQGELAEGVDRIHLKRAHSADPDSLATPELSQTPTAASESTSQVPTTGGSPANNLLSNAVGLDTPSKSIFQSPLKKYRPSVDYGPGGLNLSTGSGLKSEVDSAVSGGSGSGSGTPSNIETQKPKVEDEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECM6</accession>
    <name>S0ECM6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to Putative nicotinamide N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432212.1">
        <property type="nucleotide sequence ID" value="XM_023579364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECM6"/>
    <dbReference type="STRING" id="1279085.S0ECM6"/>
    <dbReference type="GeneID" id="35399556"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06079"/>
    <dbReference type="HOGENOM" id="CLU_056749_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="291" mass="33288" checksum="0951FD25C7764520" modified="2013-09-18" version="1">MSTSQYLQYLNRDGFVVIKSIVSRDKLDALREVSSKATQLAREGHWPYVRTVGKQFPPWDASQAREHGIWGVQHLMNPDLPGHELFTELYFSEAILGIVKQLLQCQDDHLVVELFNMLVRPERDFELRWHRDDIPAEASEDEEMERLGKHAYHAQYNFALWDDDSLIVVPGSHKRARTSTERNADPFAKSLPDQLIVKLQPGDIVFYNNNILHRGAYSSSKERMTLHGSVGHVQGSTLRARNVLQHGIGNWVDKCAFESLPEEDRRRADGMRQRLIQLGSESGQVGYSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECT0</accession>
    <name>S0ECT0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433701.1">
        <property type="nucleotide sequence ID" value="XM_023581031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECT0"/>
    <dbReference type="GeneID" id="35401762"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08286"/>
    <dbReference type="HOGENOM" id="CLU_206738_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="65" mass="7773" checksum="0CA98138EFEB6CCF" modified="2013-09-18" version="1">MAVVIEIPLPGGAGICLNMPDWIVVLIFIMIFRVWGWPMVVRRWPLAFTRYLEYDLYEPFLKFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDK5</accession>
    <name>S0EDK5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434005.1">
        <property type="nucleotide sequence ID" value="XM_023581287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDK5"/>
    <dbReference type="GeneID" id="35407534"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14080"/>
    <dbReference type="HOGENOM" id="CLU_192387_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="85" mass="9188" checksum="A72E4E7D31BD1B2E" modified="2013-09-18" version="1">MSDDQQKNESPEYTSGGKRPFVSTYENAPSLKVGDSVYLLNTDGSREGPYLVATAPVSGQCTLCHTDGNPFRNNADIDVDELEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEE4</accession>
    <name>S0EEE4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435409.1">
        <property type="nucleotide sequence ID" value="XM_023568054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEE4"/>
    <dbReference type="GeneID" id="35403450"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09983"/>
    <dbReference type="HOGENOM" id="CLU_053722_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="318" mass="37305" checksum="8A9BB8B56FAC6612" modified="2013-09-18" version="1">MRHLIETFTRFVTFRTHYGWSHDARVPLQFPRSDVEHFAILLHLIDRLCGVDFSLSLPTHRDILAFNKALRKTGLWSTNGDTPFSLTFLDEPEVSNFNAVVRRFEPDTLGAVQLPKGFNRRYYVILKKSPHSQGLKALRIDRTENRQNFRRVFPSLDHQILGEVREDFPQLESLVLHEDTPCISSYSDLRLWSLVWFNYQLAFDRTVNELATALNGRPRLRRFAFTLWFVRLHGRLVSHDGDKPYRPKSMVELDNFYINNLVSPIMAQVPTLVELCVSSEHPIFYRGIRRDDQIHVQRECRDNPGEENRFPSLLLDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFI2</accession>
    <name>S0EFI2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to trichothecene 3-O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435834.1">
        <property type="nucleotide sequence ID" value="XM_023568673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFI2"/>
    <dbReference type="STRING" id="1279085.S0EFI2"/>
    <dbReference type="GeneID" id="35402894"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09426"/>
    <dbReference type="HOGENOM" id="CLU_026450_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="499" mass="55960" checksum="DFF56AD2F1FC6DF8" modified="2013-09-18" version="1">MAGILRVVPELSPSSVAVIRAHPNSHGHVVRLSAIDQIAPRDYISTCLFFRHSPDADKQQIFLAMHKALLMTVNDIPELTCCVQKRVDNSREEVELVFDSARGVEIYYKDYNSPELCGLWTYGNFDQLEKEHFPHSKMPRSHVFGPSYKLKDNVKLPSLIVQVNFIPGGLILGSQLHHVAGDGQCNFMLWSTIGSHFAAATSEPSSTQGPPVQSLDRHDIVKGDLDTSLQEFPDWKLAEDENKFLNPTEYDSDEVFESATYFIPADKLTQLKTQILNAMPPTTKAGTISALCAFLWRHVVVARDIDCRKYPEAKLAVTVDARPRMKSPVIPSTYWGNFAEPNAVAQLPVASLQESSALSSVSSQHCTSTIYGQAAHIVQRAMAAVDDKAVRRLVGLLNQMPKSTTLTWNANRYPGPDMLIVCIQHHRYNDINFGENIGYPLAMRFTVGDTEDKPDGRCLILPPRRADSKGLEISLQYDKRTLRRLKDNAEFSEYFTRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFX6</accession>
    <name>S0EFX6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to acetylxylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435747.1">
        <property type="nucleotide sequence ID" value="XM_023568569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFX6"/>
    <dbReference type="STRING" id="1279085.S0EFX6"/>
    <dbReference type="GeneID" id="35402987"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09519"/>
    <dbReference type="HOGENOM" id="CLU_040058_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="295" mass="30774" checksum="09F23E2051F0A243" modified="2013-09-18" version="1">MRPFALSAAVFAATVLSQKKGEKTECADGLYMIAVRGTGEDKGSGRIGEIAEDVSKRVNGSIVSPLDYPATLQDPDYFDSEDAGVKALSEALDDYHSSCPNGKIAVFGYSQGGQVATDVLCGGSENKPLTMSLVKDSVVAVIAFGDPSHVANLTYDKGTSKNDGIFERPSNETKLCEDNYSDIFRSYCDTGDVYCDTGNNNETHGSYFEKYGKEVVDFVVERYEKALKEESTSTQTSTATATAATSGSATASDASATASDAPSATTAAPGNAAAGLVPGLVLAMIPLALAVSELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGJ1</accession>
    <name>S0EGJ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to protein RMD1, required for meiotic division</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433577.1">
        <property type="nucleotide sequence ID" value="XM_023580880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGJ1"/>
    <dbReference type="GeneID" id="35401897"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08421"/>
    <dbReference type="HOGENOM" id="CLU_011220_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="165"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="418" mass="46178" checksum="0F160C0760DA4AAE" modified="2013-09-18" version="1">MRNSSQRITLNVARLFHTSVAGPRLRPHRQFHLTSLASFPRKRSFFTSNPYLSQVDDGSRSASEISKEEKGPASSKRKPTRSNTAKNSLRRVAIIAQQPKRGATAPGSPSDEPSNVVSATCVAESFKMPVVLEILSSHGFDIDPDGTGFDANEVVHARGVNGGDIFVFPSGTIVTWSLPPDVVTRQIMRAAEEAHSIESREFEDLEFTTDTNREASVLKGDVIVLGTRKEHKEADKLDTTLAKVAFSSGLARSTKLAVLETALTSYFESTRNIPALLSQGAGVPLGRKFILQKTGELLSLRARLNHYSELTDSLPDIFWDTSSDLGLEGYYEQVGRALDVNVRIRALNQKMDYAAEIASVLREMSSEQHGTRLEWIIIVLIAVEVIFELRRIVLEMLQERQERKLAAELAKPTVPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGQ2</accession>
    <name>S0EGQ2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Beta-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_09341</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 8"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435913.1">
        <property type="nucleotide sequence ID" value="XM_023568768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGQ2"/>
    <dbReference type="STRING" id="1279085.S0EGQ2"/>
    <dbReference type="GeneID" id="35402810"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09341"/>
    <dbReference type="HOGENOM" id="CLU_005732_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496000" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="11">
        <location>
            <begin position="389"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT73835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1002" mass="110421" checksum="C05ECBE880623E43" modified="2013-09-18" version="1">MKLSNFFLVALAASTHAQNVLPRGTRPSNILDSRALLQDVVTFDEHSLFIRGERVTIFSAEIHPFRLPVASLYPDLFQKVKAMGFNMVSFYVDWALLEGKPGEFRSEGALDLQPFIDAAHEAGIYLLARPGPYINAEVSGGGFPGWLQRVKGLLRTNATDYLEATDNYVAHVAKIIAKAQITNGGPVILYQPENEYSAAQGTPFPNHDYLKYVNDQVRKAGVVVPLINNDAWPGGTGAPGTGPGAVDIYGHDGYPVGFDCKNPYNWPKDGLPTTWHAEHEKISPNTPYSIVEFQGGAFDPPGGYGFSNCYELTNHEFARVFYKNNIAAGVTIFNIYMTWGGTNWGNLGHSDGYTSYDYGAAIKEDRTIAREKYSEIKLQGQFLRVSPNYAIAEASNFTTTEYTDNKNIAVTALTTKKDDAFYVVRHADYRTTDSASYKLRVKTSAGTLTIPQLGGSLSLHRRDSKIHVVDYPVGKYKLLYSTAEVFTWKVLGDKTVLVLYGGPDEAHEVAVKGQETLKVVEGDGVKIEKKKGAGVFQFKTSTKRRVVQAGSLYIYLLDRNAAYKYWVPTIPSKKSGEYGSSAMNPDAVIINGPYLVRSVAVEGSKLSVQADFNTTTAVEIIGAPKGTSRLSINGKDTSFTKSKLGNWLVNPDIKLPTVKVPDLKSLDWHYIDGLPEVKKDYDDSKWRTADIKNTFNSKWPLNNSVSLYSGDYGFNAGALIFRGHFTASGSESKLKLWTFGGRAYGSSVWLDDKFLGSVTGRGNNNNDTSTYKLPKTEKGKKHIVTVIVDNMGLNGNWVPGVDESKQPRGILDWHITSDSGKETKVTKWKITGNLGGENYKDKFRGPLNEGGFFFERQGYHLPSPPLTSFKPGSPFKGLSKPGVSFFTAKLQFNLPSSTHDIPLSFTFKNNTSSTGAYRAILYVNGFQYGKYVANVGPQTDFPVPEGIWNYKGDNWIGIALWALEKSANVDGLSLTAGVPVQTGRKPVKVVEGPKYSRRQDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGR2</accession>
    <name>S0EGR2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_10258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436294.1">
        <property type="nucleotide sequence ID" value="XM_023569021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGR2"/>
    <dbReference type="STRING" id="1279085.S0EGR2"/>
    <dbReference type="GeneID" id="35403723"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10258"/>
    <dbReference type="HOGENOM" id="CLU_001570_31_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000090">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF87">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT74216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="550" mass="61938" checksum="3A96575884AD0639" modified="2013-09-18" version="1">MATKQFFLLGQAPSSARDIELPSGVDFEELQNIVASHFAIVKPNGVGFVHGDRRLTALSDVLGIDEPISVSIDGNAVRDVPGPAGIPYFGNYLEIYPDHLGNHQRLFEKYGPLFVTNSMGSRLYQTNCAELSNIFLAEDHYFTKDIVPGHPLHPIKNPEAGVFLSDTNTEQWRLAQKFLPPALGPKAVRHYAPTMQKTVEQSFKVFDELDAKGEAWNVYQYMLKLGSQAVGKLVLGMDFGHFHEVDSPLHEMVLKIAENLELNKRVSSMGAWYAKMPFGDPKKMRQTGARIMEMMAESIARASKGQEDLELQDAALKAENVVDYFLRAKDNKGSKLPPSQFAPTLLVATGAGFTTTSSLLSWLIYSLVKYPGNQERLLQELIDNDWDDDTQVTAETTNKLSFLDKFIKETQRLHNPSFQPGRTAKVDMILPGGYRLPKGAVVISALHHMHNNKDVWENPGRFDPDRWDTEKVKNRPPGSYIPFAAGPRMCVGFNFALQEIKVFLPNLVYRYKFSLAQDGPIDYDPYFQLIRPNNLYVQAEKRVKWPPKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHS7</accession>
    <name>S0EHS7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435485.1">
        <property type="nucleotide sequence ID" value="XM_023568142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHS7"/>
    <dbReference type="GeneID" id="35403371"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09904"/>
    <dbReference type="HOGENOM" id="CLU_1532682_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="175" mass="19282" checksum="1B4E120E24002FCF" modified="2013-09-18" version="1">MSPKASITFLGLHWNNCGPSPRSLGIHVVRGEMSPTRKRRRAASRIPRAHGERSHLQVYVVKNGKAPTAINDKSLSPANIRKKRSAILSYPPQPDALHQLLSVILVEQDIDEAIVRQADEGDLEDGNDSNVDGSNVCRARLIGGDYGESQQKSISKAIKNREEAKKSIEAEWVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EID3</accession>
    <name>S0EID3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to tol protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436859.1">
        <property type="nucleotide sequence ID" value="XM_023569680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EID3"/>
    <dbReference type="STRING" id="1279085.S0EID3"/>
    <dbReference type="GeneID" id="35404314"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10850"/>
    <dbReference type="HOGENOM" id="CLU_002639_5_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="74"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="554" mass="62861" checksum="CF8074A63666000F" modified="2013-09-18" version="1">MLQEWAADFQASTSSEKVHRLASGWYEACSQSHELCHRLRSSPNFAPSRLIDIGSGDIWKLCLYPQDIMDPPEYMTLSYRWAKVPSISLFSSNFEVFRKGAPISQLPKTFREAITVARRFSIRYLWIDSLCIIQDSPEDWARESLQMHLVYANSACTISATASEGPDEGLFRLRTARETLVGHIKVPFADGKPRRFDVWDQHYMQRLTQGPLTHRGWVFQERILSPRVLHFTKTQAVWECFEMNKSEMFPRWSPQPTDAVYTPDLKAIDAFFDDGHRRTAWAKEEDKTMTVDVYQQWTNLVKTYSKCRLTYADDRLMAMAGIAEMFKKNSGDEYLAGLWESRIVEGLNWVVLEPRPRPQNPDRVPSWSWAAVDSGVLPQRTNLPRDEDLIEIIDVRSHLVETSSRSQQVKGSIQLRGCICEGIVRESSRRIGAQNIGLKLLEMSATIYAYPDTLETTFQGGKSLSFLPLRSALRRQVNNPDENPVGEAFAIIEGLILQALYGAGSSYKRIGLFVLDSLDNASFFGLVATLPPESGGGVPLISADESRKSNIRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIN7</accession>
    <name>S0EIN7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435805.1">
        <property type="nucleotide sequence ID" value="XM_023568642.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EIN7"/>
    <dbReference type="GeneID" id="35402923"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09455"/>
    <dbReference type="HOGENOM" id="CLU_001419_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="823"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1766"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1815"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="830"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1768"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1824"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1854"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1873"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1922"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1955"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2020"/>
            <end position="2037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2037" mass="230460" checksum="E9052FB1654B96D0" modified="2013-09-18" version="1">MSAVALEVLRPPIWYDTQIWERTFANEILKPAFQAINLEPEDNIDEQIDTTKEIHVDEALKRFQNALKLHAQGPRSREAAENAYNELFESEIFKYREAKTDYERAERHADGQPDVSNLDHSLTDGGLDVDAGGADGVAASLSQALYLSYKNYGQFFVDKYKDESTSNPAFKEKTRLKYHDDHANQVLDRWMAALDQDPSDPELWRRAARFAGAMNSHRIKRYCLEAAIELDDDPAVVEVDPPSLAEGMAGEQLKDHLQLLGDDMALSHPIMAPWLKKKMPALLKRHLDPIPFLPDPTKSLIPPKDPITQDQTAEDTEMRDAENASRSDPKTVLSWASLGDEIINRLTNYTEVFDIFDEILESSVDEAVVETPSNDSESISSEIQVAIGRPIQPAESSEKSSPEAEPKDQKAASEATEDSQKAADQTRKEANGVSTRKRSQSAAGLPDGAEEENATEKRSKRVRRRETLQAEDSTDPSTLIANQLQPYQGADQNLFQMTKSVLENLGVDDKSTFDFITELIDSCAVEDRPGKIANLAAGDLSSAIVDFREEVAKVFLHKNEQAPLGPSSFLEHAKTSSQDQNSTPTFNETQGLRSFATKIGESRSWMTIDDVAYEWVRAVSQSYATTKWSDKMKLSVVQMLNHSDAALHQRINEKIELAAGSPEKLAELETIVPMIYELHIDVYELITNPNSVVDYATRMKTKYRLGRWLNVASAYIQALDRPSNDELSARFLWTSVLVSSHSERPVREHILLMWTSLRDHLTDENIPTISLPNNVVMPTISPQAADREISKLTTMDFFLGLFQDNMEDPVSVIETLEPVLNPSSVCVPDQETEPESPCTEDDDSSSSSSDKQKKSLSDCASQSLQDLWKFLHNSSTELRLFLWSRLGTAYHAIGYPTKQFSGYLKSIELIVSDLESETYANTPADSRKLLFMRTLKSLDELLISALYSALNDNTAFEIIDDAHIKSTTAALAKVNCLLHVSSLCEDEVRIGLKTERPGNAASKAALQSLKNRLKEMQIRAWCLQYTMFKAGINEDNCIIGPEKDLADFLAAIHQVIGIRKFCKASNKIFLKVMRVELLKLKNIENWEDYLGQVLYDLHGLKLGAGVWEVQDHACPPEKLEKRQTMQLVERVTILANRMPMKDLLKSDLKTTIDHMQQTLGQAKSTSQMYHNLRNFTEYLKRPIHPLRLYRALTGEVSVDAVSVNTPETILATHGWFFLLGMMALTKFKGVDLNRRQTPGATDDLRIGATFLRLQLQFTADRWDAWFRLAECFDYELDESVLWTADKMNKDRPELVKFQRNAIHCYTLALSHSRNVEVETHDGDPLHDLYHKFAMRMYASSREPFAMEPFHHSDQERYFIEDMGAGTFKKILHPQMNEYKVWKFAAKLFRMAMQRKPTDWKNPYMLSKCYWKMYQTSDDQLDVKDIKSKISIELLIHTLQKAVTVAHNARRGRNSDPILEPHYKIVSILHKLVIRGDLSSKEAAAILAEQPFGLAVNPDDHFASFTEPEDWEEYIIRNLTKLRDKDKSNWQHRIIIRHARILFDEANEAQGSDRLVEAKAAFGILRDSMVTKTMVMNVWKCDAERPGRHHVYTEQYVRFMTKLLVIMSDRNNLEQLLRRLRKKGADYYHFTDLWQSCCMAYLKLLREGYHVSPVSDDVFKSLSSEEFEVIGERIADWAASDGADIPLFNCMKETIELKKLNANLTKVAPIDDLLNDCYSRIYSEIAKTLPGPDPSKVVEERHHAKEVAAQLEAAQAEAKATSSLANILNAPNGQESITGTATPMETEKHEAAPRARKLGVRRPDVLRKAEQAVVRALEAPKSSKSRVGSVSSGKRGSHTPIQHASDAGSDEEADAQIRREAGHDVDIDMKDAGDEHEEEHEEDHEDHEEEHDEDHEDGADEDNGEEHAEDKAESEEGSIHDSADDESDLSDVPEDYDEEVPPGLIFPNLRRHNDESSGEDADSESEGDDEAEESDGEEEAEEVAEEEEEHDESREDGEETLGNEDTELVDGEEEEDEVDGDERREDWDADDSVRAEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIY5</accession>
    <name>S0EIY5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437044.1">
        <property type="nucleotide sequence ID" value="XM_023569892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIY5"/>
    <dbReference type="GeneID" id="35404504"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11040"/>
    <dbReference type="HOGENOM" id="CLU_599979_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="509" mass="56907" checksum="A206882E4AA484B9" modified="2013-09-18" version="1">MAVSAGCSASGCLNLPWACMRRKATDEPQELENEVYAEKKLSRSCFRFSRLEMLQTKSQQISGSMSSFIEIETSPLLAESNTDEAKRVRDEAKATLQQKYPTLVDMAAIDILKVFGAMREARLEIAELCISISFPLVILQCRSLSNLLASLSAFDDHGKVPEMTWHARNLSMLGKLENGFGYSWRYQWCLVFERWSDHVKDYHWLSDKTGDLQSNVAHIRPIFLLLKEAFLQIDKMAGTSLVDLLSDVQHAFDMFEHRLGECSAKADELRVEQERPKHLSPFVNSSSGQSWSSGSNIPSGGITQRTSFGRDGNTTAVQMDNSSTKPKERRLTKLRQRFSINPDARENHWTTLFGLGKSPVVLILTTAMPPTIYSTILCGPPDVVPALDSNFYSTLSQFISSLAGLYVIVKPIFSGNKKDQIKTSFPKTFYTMLTLSLLTSLTSAVTYAWSPAASIPLAYVSGLTLNIATLLIIQDSGNQIKETNRYNEDLVFAVNELEMELAENRAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ14</accession>
    <name>S0EJ14_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBM-cenC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437069.1">
        <property type="nucleotide sequence ID" value="XM_023569920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ14"/>
    <dbReference type="STRING" id="1279085.S0EJ14"/>
    <dbReference type="GeneID" id="35404528"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11064"/>
    <dbReference type="HOGENOM" id="CLU_906256_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485969" description="CBM-cenC domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="31737" checksum="3CFC8FCBAFF02DD9" modified="2013-09-18" version="1">MLFLKYSAVVAAFALYGQTSAGPCKPVTRATSSDLETSSTVTNEASSTVTNSLSAETSATVETSSVATSVESSATTFSSEASTTAGDSSTLFTSTATLDATTTEFVSTSTDVSTTATATTSAAPVCEFTGVYTNYVKNPSFDNLDGNGDPTVDPWILLGVSTLTTNFPRTGARSMAYSYPDAAVGGSSSILQELTNTVAGQEYVFKFHYALIEGQPLESEECRIGTFAGSGGANRLFLAVDGDQAIVQDQYYEQEYRITAENDNQRLSIGFFCTSQPSAGTVKIQIDDVSVYDYYEGCESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJL6</accession>
    <name>S0EJL6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434636.1">
        <property type="nucleotide sequence ID" value="XM_023582042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJL6"/>
    <dbReference type="GeneID" id="35405892"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12436"/>
    <dbReference type="HOGENOM" id="CLU_041445_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="41402" checksum="75FCDDFDE5EE69B5" modified="2013-09-18" version="1">MGGLLLSDHYEFHKPSTNDMNIASIAWGFSLGVSIFAGTKAAKQTIKSWKRGTRTNIYLVLVWMEWTSSVIMSAITWLYLRQYIPPGFPVFFVIVLLWAIQIQSLLQIIINRISILMVNRHNAWKLKLIVFLVLLAINISVFCVWIPARLQISAKWIAVNAVWDRVEKCIFLIVDAGLNFYFIYLVRSRLIANGLTKYTRLYRVNLFMIAVSMTMDVLLIAMMSLPNDIVYLQFHPLTYLVKLHIEMNMAELITKVVKASNPNGYDYSDSRSRSGQKSGKTTTGKKMGSVFPGNNQTFIEAGGNDIELPQRKEDGIQVSRTFKTTQIEVVKENRDRTDYDDLESESSSTRHLKREPLPFPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJM4</accession>
    <name>S0EJM4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to KP4 killer toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434646.1">
        <property type="nucleotide sequence ID" value="XM_023582054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJM4"/>
    <dbReference type="GeneID" id="35405903"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12447"/>
    <dbReference type="HOGENOM" id="CLU_123452_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.10">
        <property type="entry name" value="Killer Toxin P4, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015131">
        <property type="entry name" value="Killer_tox_Kp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011329">
        <property type="entry name" value="Killer_tox_Kp4/SMK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09044">
        <property type="entry name" value="Kp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55221">
        <property type="entry name" value="Yeast killer toxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485984" evidence="1">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Killer toxin Kp4" evidence="2">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="127" mass="13323" checksum="21D03B20F2C0708F" modified="2013-09-18" version="1">MHITAILATALVAASSVAAGINCKGSVLCGQGTEPLSNLINYAGGLNDDRWYQNGQHIVCGGSLCAFLQNTGGLPGREIKRLLGELRNHGCKYCGSVPVFFPDDNNDGDHGILTVNYVSNPNCQGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJV8</accession>
    <name>S0EJV8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436225.1">
        <property type="nucleotide sequence ID" value="XM_023568393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJV8"/>
    <dbReference type="STRING" id="1279085.S0EJV8"/>
    <dbReference type="GeneID" id="35403145"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09677"/>
    <dbReference type="HOGENOM" id="CLU_069416_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="311" mass="33314" checksum="559D6F59A63CE09D" modified="2013-09-18" version="1">MSEARCCVNDPCGRNNGTCPGGDLRATSFASDKYSQLPQQECDNSQGADNWHSCAHTEPPFLGCCSQNACSSECPRAKLVPAKLSEIENNRLNFLHPSQSQSSATSSVSETASTTASSTSVVDVNEGDGLGAGATAGIAVGALVGGLIVLVLVAWLFWWKPRQKNKHQREHDPGYSVPPAAPTLSANPFPPPSGPIHPSTFVAQSPMSGYQPVYPLLNSSKSIFRIFLILNDRNPPHTFRSTVPNTHTVPNFFLRTSNSTITVTTNQQQMGVASEMVGSTTLPQEMSTGAEHRINRHSSIVPETELSLARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK00</accession>
    <name>S0EK00_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437167.1">
        <property type="nucleotide sequence ID" value="XM_023570042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK00"/>
    <dbReference type="STRING" id="1279085.S0EK00"/>
    <dbReference type="GeneID" id="35404637"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11173"/>
    <dbReference type="HOGENOM" id="CLU_388852_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="250"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="710" mass="79392" checksum="4FA29FEB86075727" modified="2013-09-18" version="1">MDMQPSPRNNGSGSLESDLARKRDHSGADMPAPKRQRTILACNRCRARKVKVSALFNPTLPINVGAKMIHQCDGGYPSCFHCQDTDARCEYRTPHREQQEAIPDNTLILEQRLKALEDTVQRLRKTSCSTAEESDESDTPELVIQDLPEDFTQVQYLCSSSAQDGIGSTGEEFYGPSSNIFYLRQILGEVDSTTLSSFRGMDSKISEFIKPECSPPAAVFHMESVPVAKHTDNEGLYVLPPDHATRSLVELFFRDYGSMNPFLDKATFFHTHVDPIYKSTLPPDASKLALLDMVLAIATASSIDSITPTTRRFFISRLFFERSKSLLSKDDLACGNLEQVQSYLLMSQYLQSTDRCSDSWSTYSMAVQKALRQGLHNVDYLAKDFAAEREAKRRTWQLSPFQCILAVRLCWGLMYNELITSKLYAILGQIVNTEYFQSPKPLDLSRFMDIIASIACMSQKLDEWLDSLPEEWRAAIIDSSAAPVDEANSQNNLYRVLGLRYHNVRLMLHRPALVLVLSAVGKLANSNDITPTSRRQILMFSRPSLETSIDSAEAIVATINAFEGGKPGPGMWWTLIQIVYNAALTCFALICLQTRDAAFGGSQAAFKARVYVDLARQAFCKLVPDHPAVERASSFLRHIARLCDHIVQQNVSTVLIDSVLNIPLSQADTEYLGPESFPFDFSMFEPLDDPLFTNHQSISEGDTDVGIAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL30</accession>
    <name>S0EL30_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_12220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435156.1">
        <property type="nucleotide sequence ID" value="XM_023581800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL30"/>
    <dbReference type="STRING" id="1279085.S0EL30"/>
    <dbReference type="GeneID" id="35405676"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12220"/>
    <dbReference type="HOGENOM" id="CLU_001042_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="540"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="191"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="421"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="690"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="860"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT73078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1254" mass="143751" checksum="F30C1DC35A196FD9" modified="2013-09-18" version="1">MGKLIRLELFNFKSYKGHHVLLFGNSYFTSIIGPNGSGKSNSMDAISFVLGIKSSHLRSAHLKDLVYRGRVLKTAKINDDGSAQTNGDANGDADGNDKASRGDPKTAWVMAVYEDDAGEEQKWKRSITNQGASEYRINDRVVTAQQYNESLESENILIKARNFLVFQGDVEAIASQSPQDLTRLIEQISGSLEYKTEYEKTQLEAEQAAENQNFQLHRRRGINSEIKQYREQKKEADNFQNKTDERDAAIVTHSLWKLYHFQKAMEDSFAAIQDHQENLKELRRNVESFEKRLEAARKEQASANRQVARLDKEIKTKERDIEDKENSLVPIEEKINESTQAVETLQAAIAKATRERDEQAEVVRQVQKDIESVEKARQVFENDYKEQMKKQGREISDEDRREYNRLRTQLMSRTGSNQAKLENLDRQRKADEVTVNNLKGKVDSIAANIEKIEAELSSIEERRSAAQATSKDLSQEIDAKKKEFNKLQSERVRTNQKRTELEEKLEDVARKLREADDGRRQNDREARMKEMVTSLKRMFPGVRGRVGDLCKPKQKKFDEAVIVALGRDFDAVVVDSEKIGVECVQYLKEQRFQPMTFIPLDNIKVNAVNTAVKGFSGARLTIDTIDFDSSVERAMSYACGSSVVCDTLDIAKHICYEKRIPVKAVTLEGYIIHKAGLMTGGRGPESKSKRRFEEADVQNLQRMATKLKDEIDRLPNAERRGSQEETLQIDLSGLERRLAAVKDELAAFNKNHASKKRELDNQRRQLRELEPKYQDQASQLESTTATCEEFRNAIARVEDDVFADFCRRLGYSDIRSYRDSQGKLEQEVSEKRNEFEVQKQKLSSRLQWEQQRWETATARIERNQAHVRKLRNDINSYAREKDAIENAMSEEQAELEALREALDENKSELTEKNQKVSEAKLEVQKRSKDIEAHLKDINSLETVVQKNSASKAALLRRCRLEQIRIPLAEGTLENLPNDDRLLNQDPDAMDIDDEDDDEEMMGMALDDHGITIDFSGLDEELKVSDDPSVEESLSEKITNLTSELEKLNPNMRAMERLESVESRLRVTDQEYEDSKTAAHEAKEVFNRVKQKRYDLFNKAFSHIQEQISHVYKDLTRSEAYPLGGQAYLDIEEDTDMPYLSGIKYHAMPPLKRFRDMEHLSGGEKTMAALALLFAIHSYQPSPFFVLDEVDAALDNANVDKIKKYIKDHRGPGMQFIVISLKAGLFQDSDSLVGVYRDQEVNSSRTLTLDLRQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL65</accession>
    <name>S0EL65_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to E.coli tetracycline resistance protein TCR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_10701</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436720.1">
        <property type="nucleotide sequence ID" value="XM_023569514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL65"/>
    <dbReference type="GeneID" id="35404165"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10701"/>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
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        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT74642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="550" mass="59533" checksum="7E2C66BBE1BBB74C" modified="2013-09-18" version="1">MIISRALTTTAAICRFSEPIAFNSILAYTFVMVKDLGIAEKDASLYAGLLVSAYAVAEALTSMGWGILSDRVGRKPVVLFGLVGVALSSLIFGLAKSYWVALLARFVGGALNGNVSVMQTMVAEMVKLPEHEPKAYAVQPFVWTLGGIIGSAMGGFLAQPAKFYPSVFSEDGLFGRYPYLLPNLVSVAVVAIAVIQGLFLLEETLVKPGSEGENGVINYQEVPAIDDLESIDERTPLRRSAVRTSVSRSRRHMSPSTSRSRPRFAESSLGMAVEHDFIDLRRSSFGTVHSIVLPQDLLTPPNEEQEDEQAKSGERTFNKTIMMLIVALLIFSYHQMAASSLLATYLLDGPSEKRGAIDWIGGLGYTVHDVGVYLAVNGVLGLFIQAVIFPVFVSRVGVWHSFVSMIILYPASYMLMPFLSAFGEPFVSFGIYASLLMQSFCGLIVAPVTLILIKDATPSPQVLGRVNGLAMSGACLARTVAPPLAGVFYALSGSVSAWFSCVVVAVIGAVQLFWIPRRSIKRDDVMVDNALTKTVTNESRRGRRGRNSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL88</accession>
    <name>S0EL88_GIBF5</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435221.1">
        <property type="nucleotide sequence ID" value="XM_023567829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL88"/>
    <dbReference type="STRING" id="1279085.S0EL88"/>
    <dbReference type="GeneID" id="35403652"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10186"/>
    <dbReference type="HOGENOM" id="CLU_2704990_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="73" mass="8643" checksum="4963ABC081DA7F32" modified="2013-09-18" version="1">MHSNEFSYNSYFIHEKDLKYVPPYLKDVPETPNEVEYRTSGSWPTWIEGKLLRIGEGRFTNPFSQQSHQHPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELB4</accession>
    <name>S0ELB4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_10153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CCT73173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435251.1">
        <property type="nucleotide sequence ID" value="XM_023567867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELB4"/>
    <dbReference type="STRING" id="1279085.S0ELB4"/>
    <dbReference type="GeneID" id="35403619"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10153"/>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00943">
        <property type="entry name" value="CUATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="757"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="56"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT73173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="817" mass="88320" checksum="F1B5CF2FD4A899CC" modified="2013-09-18" version="1">MACCYIAAFCISQLVKVYQFLDVDDAIQYNEDEPEFPYPNTKSTDGNYAECEKHNASLVLSLSGMTCSACSSDVESALRNHPDVDQARVSLALQQATLIGRTSSLDSQSIMTLVTDLGYGVELGPRSPQEIIRVLKFKEEIARLKSSLSSLPGCATVIQTVGFLASIGHGRLPSATLFIAHLLCAALTLFAQGRYIPWIHEDGWKAICRGQPNMNTLVSSSISLGTFISFIDLFAYGTADANSYYTTVIGLALVVVAGRYIELMSRRTTSEDLLRVYKPLTKSNYTRLHPTGKTVPQSYLTAGDQIAIPPYSIIPCDCYVTEGTSSINQALITGEALPVQKSVGDFLLGGTRNLGNELVAVVDKEQGNSFYSQLVHGAVEAAGSKDEDNRTVDMVTKYLVGFVMSLAVLVPLKEIYTATESLSYETIRVALARAMTILNCACPCALGIAIPSAVVAAVGTASQNGLLITKGYNTIQKLSNTQSIVFDKTGTLTRAILDVTDFETTKALKKPTTEFWTYTCAVEERSVTSHPIGRAVFTAGVSHLDGPWSETKAFVETRNITTESGKGVSGEVSLGQEPWRRVDIGSRRYLLSCGVSDLPVISQGQGGGAIAVYVAIDRTYAGILYVTDAVRDDAERTIQRLHTMGYATHLLTGDMPQSAHRISQQLKIPVLASEATPQDKLDLIKELQKEGEAVAMVGDGLNDGLSLAAADVGIALYHDVATPTVGATVFILNSRLDSIPLLLEIAELTMKQVRYNLVWVFGYNALALSMASGLFTPYGIVLTPQLAAACMSFSSIFLTLNGFWLRNRLATVFRTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM07</accession>
    <name>S0EM07_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to sedoheptulose-1,7-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_11654</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437668.1">
        <property type="nucleotide sequence ID" value="XM_023570577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM07"/>
    <dbReference type="STRING" id="1279085.S0EM07"/>
    <dbReference type="GeneID" id="35405115"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11654"/>
    <dbReference type="HOGENOM" id="CLU_039977_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023079">
        <property type="entry name" value="SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF35">
        <property type="entry name" value="SEDOHEPTULOSE-1,7-BISPHOSPHATASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01958">
        <property type="entry name" value="S17BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="9">
        <location>
            <begin position="54"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="10">
        <location>
            <begin position="207"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT75622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="332" mass="35493" checksum="79EB20415D0E0091" modified="2013-09-18" version="1">MSSTKAPELELAPFLKSALPQESRASLRDSVIPQLLSAIADIGKGLRGSYDVSIVGTENAFGDEQLNVDVLAENIIRDGIAKSSAIKTASSEEDPVEKPARAGETTQVDTSVEQYTVAFDPLDGSSIIGPNWSVGTIIGIWDGVTAVGQPTEKQIGSVLGVFGPRTLAIVALRVPGSEPKCFEVSLNDTQKFVVARPELRLAEPPFKTRYFAPANLRAAADNEKYMNLVTSFITNKYTLRYSGGLIPDIYHALVKGHGVYISPVTSASKAKLRRLYELLPVALVVECASGQAIDPETGARVFDTVLKGCDDRAGLVCGTAEEVEKVKRALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM25</accession>
    <name>S0EM25_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_09757</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435526.1">
        <property type="nucleotide sequence ID" value="XM_023568305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM25"/>
    <dbReference type="STRING" id="1279085.S0EM25"/>
    <dbReference type="GeneID" id="35403224"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09757"/>
    <dbReference type="HOGENOM" id="CLU_002761_1_0_1"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000043">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13418">
        <property type="entry name" value="Beta-prop_TYW4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="16">
        <location>
            <begin position="835"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT73448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1024" mass="114185" checksum="2E5E7633BF3F1E49" modified="2013-09-18" version="1">MAKGNPPSTKMTRTQALDDQIMGTNSSSIVSKRSVERLYYPDELHFFRYFVNKFQRRAPLINRGYWLRLRAIDVIVRQFVTSPKPGRKKVVINLGAGSDVLPWQSYHRYGDSCENTLFIDVDYPDLMLRKRAIVLGTPQLHELLGDSPAISENVTDQILLRSDKYCQIGCDLRELESLRNCLESFLNLCECSVLFVAEVSITYMDTFSADALIQWASSIGQAEFCLLEQILPHGPDHPFASTMLKHFNKLNTSLKSVDKYPTVESQRRRFQERGWSSVDVWDLWEAWNSDLFLDSTERAALDDVEPFDEWEEFVLFSRHYVVLHATAYHRDERGAGQCGHVGVSSKYVKANVTSLGWLGAPKRRFGAPLIAYNPEGDKYLINSLGMGVKARLDSCDIYSLQQDSIALEMSPAGPTARLCHATVDIGHLGTLLIGGRASPSKALNDCWIFKKDSNRWEKTFDLPAPLFRHCAVHLPGSSLALVLGGKTGPSEISHDYYVFHPVNGWLKCSVTGAKPSSTFGALAVASPNPGSKHGTFEGLMAGGISKYGKINEQAYFWTINVSTNVPHIHFEIVTDSHGYARSLSVFGAQTAGVESLHFVCGGVGQDPSSQGQSMTCISVKDGHLEEFNVDLRNDARQLPFMVGSATVSSGSELVVLGGGATCFSMGTFWDAGVYKIDLKDPLTEMPHIQPANCSPASVNYQDSPKLAHQTTTIDWHQPTLQPSIKSIARIKLQSKLDFEQLIENRRPVIIESLDLGGCVDKWSPEYMVQRVGQTKEIVVHECQSSAGKMDFNSKNFRYVTEPFSAFMAKAARGEAVYLRALSEAKPTEFPANLQDDFPTLADDFQLPEELSLIKDRMFSSVLRISGRAKMWLHYDVMANVYTQIQGSKRMILLPPMDVNNLAFAPGASSSSLDVLSALDKQELVSTTNPYEAILNPGDLLYIPAMWLHTASPTTDLSVAVNVFFRDLDSGYSTGRDVYGNRDLAAYEKARQDISRIVKSFDRLPSEIRDFYLKRLADELLHKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMC6</accession>
    <name>S0EMC6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="5 12">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_12030</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="5 12"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438022.1">
        <property type="nucleotide sequence ID" value="XM_023570995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMC6"/>
    <dbReference type="STRING" id="1279085.S0EMC6"/>
    <dbReference type="GeneID" id="35405490"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12030"/>
    <dbReference type="HOGENOM" id="CLU_008878_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="14">
        <location>
            <begin position="245"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="15">
        <location>
            <begin position="644"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT75976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="721" mass="78232" checksum="93950678C62DF3D7" modified="2013-09-18" version="1">MTERTAVGLPTGPSSGPLTDAQWQVMMAIMDTIIAPCPESAIPAGQKSALLSNCDDSTLKAFLDEKPSNMPLFQEILKRLLANLHADKLSAIGTVCSLLGNRAAVLPLTGYFTLFCDLSPQDRTLVLNSWQTSSLATFRVLFKQLSIIAKHVYLRSSTLFNEVVGFPSTPTGWHPVESYPFEFMQFNDAETHVKLETDVVIVGSGCGAGVVARTMAMAGHRVLVVDKGQHFETSSLPLDQSAGYFHLFEGGGLVSSEDGSISTLAGSCFGGGGTVNWSACLQPQNIVRDEWADQRGLSFFKSAKFQEHLDSVCERMGVSNEPINHNHGNNVLLEGGRRLGYSAKQVPQNTGHSEHLDGYCSMGCWKGQKNGPVNGWLPDAARCGAKFISGFCVNRVLFKKRGGKNVAFGVTGTWRPRDGSDTSARTVTINAKRVVISAGSLCSPIILKNSGLKNKHIGRNLHLHPTSFVSAIFEQETRPWEGGILTSVVSSFDNVDGHGHGVRLERPAMLPSMCLTWCNWTSGADYKATISKYRHMEAYIAITRDRDSGHVTADPINGTPRLVYTPSKFDASNNMKGMLGLAKILYVQGALEIHPILPGLEPFMREPESLKNGVDSSSGVTDAKFSQWLKKMEAHGNKTPDTPYGSAHQMGTCRMSTKESDGVVDEFGRVWGCENLVVADASVFPSASGVNPMITTMAISEHIALAMADELARDTQERPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMY7</accession>
    <name>S0EMY7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438242.1">
        <property type="nucleotide sequence ID" value="XM_023571188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMY7"/>
    <dbReference type="STRING" id="1279085.S0EMY7"/>
    <dbReference type="GeneID" id="35407623"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14171"/>
    <dbReference type="HOGENOM" id="CLU_537447_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT76196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="633" mass="71792" checksum="CF3547B58D16617D" modified="2013-09-18" version="1">MTTLNGGRNVNDAGSRLVELRDGHEIIALATEDPAQLSAPSAPKRYALPADWEQHRETIRRLYLDENRTLNDVMHIMEHDYNHRGSRKQYKTKLRKWELDRKYKKRQNAQNKETKSNRHRSRAGQPSTASLVNYESQTHEADATSDNCIQGPDIEIANDAFPELADAGSLASDLYEDPSRINAANPIFQYADANVEYPDFQPLNDSNTGIELFGNLSPRVPVANLSIEHVIEDPYLNLDGNQQSKDLDDVRAGIQSPQNMNVTSTGNREHQQPSFSHRQSLAMSQAVGIRSGRSATPPLSIDEKILSLAQQHIETSFTYRIWKLDSNGTCTSINCTSDGLELPETFFDLIRSAHLLLEQGSTNEGIHVVSKAFALVKPIIKSGNVRALNFFWASLVFLVQFGHVDIVIRLMRHIYEMAKILLLPQHPVVQIFKLLNGIDVSKLEDFVHRSWQATADEFQKQLPPLHPEYIRHQCDLIFRIYGTRDAATGEQRLLQLLKSCDETPQTKELSHLTVLNAIGYNFMNSKKWAEAVNIGVKLEDRAQRADDIDLLVYKIGGMEIQARAYNELKLVEPAVKCLKQAIPLIAKEWGQDDPWRIELMTLQQKWLRENNDAMAADDIKEEIRTITESIDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN62</accession>
    <name>S0EN62_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Efflux pump antibiotic resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437445.1">
        <property type="nucleotide sequence ID" value="XM_023570316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN62"/>
    <dbReference type="STRING" id="1279085.S0EN62"/>
    <dbReference type="GeneID" id="35404881"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11419"/>
    <dbReference type="HOGENOM" id="CLU_061199_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31773" checksum="C307F9318F117724" modified="2013-09-18" version="1">MESLTTKSSPPKNGINIIHAGLYRTGTASMAAAYRILGYKAHHALHNEWHEPWGKLEQAAEATFPHLINLPDYTHNGPRPPFTREGWHSLWGAYDIATDIASTFTLELIKAYPDAKVVIVQRRFEDWWPSFQSEILVSVFEATWLQKFLTWYVLRFRALHAMRKILAGFFSVNEYSVEAITPDIARGTYEEFYSKVREAVPRERRLDYSLGDGWEPLCEFLRKDIPDVEFPRVNDRKTHSEDMERLMAKLMRASMGVLGPYLISVLAVAVVFYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENT0</accession>
    <name>S0ENT0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436426.1">
        <property type="nucleotide sequence ID" value="XM_023569175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENT0"/>
    <dbReference type="GeneID" id="35403861"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10396"/>
    <dbReference type="HOGENOM" id="CLU_052695_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="298" mass="33293" checksum="CB1A67B395B218BF" modified="2013-09-18" version="1">MSPENTDPLAGLDSVDWSQLSHAYGSADDVPQLLKDLQSTDPEVYKTALTKCWSNIYHQGSRYSASVEAIPFLYALLDSPGTKDRESLLYLITSLAIGHPDWSVPNGIDIDNWERSIAEIEKPEYRERAMQGFKTYEAVERGLSSILRCLGKDSASMRANAAHALAFFPRQSATSKVALLNRLSGETNNNVSATAVLALAVLFARADEDLEKRDLIRKVQEYHTASLIREEFEDIVGWSCAVALFILGSKEDKLAETVRRVNENKSYVEKLESTLDQDVWFPFASLNLRDLAKSVLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPC8</accession>
    <name>S0EPC8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436971.1">
        <property type="nucleotide sequence ID" value="XM_023569809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPC8"/>
    <dbReference type="GeneID" id="35404429"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10965"/>
    <dbReference type="HOGENOM" id="CLU_030671_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36512" checksum="5C6D0BF17646C496" modified="2013-09-18" version="1">MSNFSFPEFDDLPVVKGQPKGCLWGIFDVDGQKDQLGTLRLLTKEVVQKAKDEIRTGTHVQLDWPLHNIEFPGFGRIPLQHTVKDLAEEGFVAFDDVISFNTQTSSQWDSLKHFGSQKTAVYYNGWTHDQLKTSNDLGIHKICDRGGIVGRGILVDWLSWWEHKNPGIEPPSAISCHKIPVSELEATLAYQGTETRQGDILIVRSGFVRWHNNAKADIRALGTEKQHYMIGLENNDETVRWLYSKHFSAVAGDTMGFEAWPYPEDCCLHEWLLVQWGTPIGELWDLEALAEECKAHNRWSFFLASAPLRVVGGCASPPNAIAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPR0</accession>
    <name>S0EPR0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437631.1">
        <property type="nucleotide sequence ID" value="XM_023570532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPR0"/>
    <dbReference type="GeneID" id="35405074"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11613"/>
    <dbReference type="HOGENOM" id="CLU_041445_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38244" checksum="FB977A5589DE7D25" modified="2013-09-18" version="1">MIDLASVYYGLFLGVFIFTFAKAVSQTRAIYKRTHSLHNAYLYMIWTEAVVNFVFALITFLYLNGIIPRNLGFLLATVILWSIQTQLLPQIIANRVSLIMTNRRRARHLKWGLVVCILFVNGAVCYIFTVAHLDTATTSQKHTNMIFEKCEKTFFLIIDLALNMYFLYLVRYRLIADGLNKYWRLFNFNAGMVFISTSMDVLLLGFLSLPDPYLYVQFAPLAYIVKLYIELLMANLISKVVRGTSRSQGEGWYSSSRDKSNPTNYGLTSRVVVTTGPPVPTRGSNIMSRMGKDGKDLESNEGNNGSQVHLATFPEPHGITKTVETTVVVGDGESDRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPS9</accession>
    <name>S0EPS9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to nonphototropic hypocotyl protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_11713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437726.1">
        <property type="nucleotide sequence ID" value="XM_023570644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPS9"/>
    <dbReference type="STRING" id="1279085.S0EPS9"/>
    <dbReference type="GeneID" id="35405174"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11713"/>
    <dbReference type="HOGENOM" id="CLU_012260_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF9">
        <property type="entry name" value="PAS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="285"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT75680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="674" mass="75192" checksum="41E30AF94577A48C" modified="2013-09-18" version="1">MPTQHLNLVDDEMDSQPPPIPLRAQTPRRQVAMKQSFETQDLGDGMANFDPELLQAPSSRASSRAMSYRTQESQIWSHKDRDASSISSVYVPTHLPALQAKGAGLDRDGLEPLTEEEYDPASFDLVVPAHAMGKQYTLETQSELLFSVKHLSVIFDDPVLLQRFTNFLSASRPSSVPLLTYYLDTLKAMKAINYANSLTGSLKTIDGHDFTADPVTATVNEALAKRATEAFQAMVNHDLPAYITHTYIQTVSITIKRRITDTLAPQLRDLSEGLAEVFCLTDPSRSDNPIVFASEEFHRTTQYGMDYVLGRNCRFLQGPKTNPFSVKRIREKLAAGQDHCETFLNYRRDGSPFMNLLMVSPLYDSRGVVRYHLGAQVDVSGLVKECAGLDSLETLMADENPENERYPGESEQRKKNEEKDEFQELAEMFDLAELKTVREAGGAFHRTHQQDVRQTDAVPANWNKPRLVFRDDATINRRPSDPVLHDTAMASFGGRLSGIYKHYLLVRPYPSLRILFASPSLRVPGMLQSSFLSRIGGSDRVRETLTQAFAGGNGLTAKIRWLSKAEVQTKNRNSRAMDHSASGDGGQAPPANPGRNRWIHCTPLLGSNGAVGVWMVVLIDDESDQAFMRGLRREAPPVQPQPVQQQQQPQASHELYGDDDKMSLSSFAAAHRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPW1</accession>
    <name>S0EPW1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_11884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437886.1">
        <property type="nucleotide sequence ID" value="XM_023570832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPW1"/>
    <dbReference type="STRING" id="1279085.S0EPW1"/>
    <dbReference type="GeneID" id="35405344"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11884"/>
    <dbReference type="HOGENOM" id="CLU_046582_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="15"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT75840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="292" mass="33004" checksum="EAF7E0330FFE1813" modified="2013-09-18" version="1">MGSIPAQKKKPTPVFLFAHGSTMMLGEESEPARIWESIGNECLRRGVKRIVMMGAHWDSPYDTIRVSMNPDAKKDPVGSVTEARYMPYKMVADLEGGQRVIDMLRGAGINAQADPKFEWVHDTFLIIIRMFPHCIPLPTTIVSMNARYDPHLHTKIGVALRPLRYEDTLIIGSGGSVHNLYRNHWYQMLTYRDNFAQPVPPGDFALEFRQALEDAVTQNTGPALRRAVTRLMKHPRYKEAHGTDDHYMATLFAAGAAGSHEDQGPNRFLGECWELVNMCNSQYQLGDWDDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPZ4</accession>
    <name>S0EPZ4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438051.1">
        <property type="nucleotide sequence ID" value="XM_023571032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPZ4"/>
    <dbReference type="GeneID" id="35405523"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12063"/>
    <dbReference type="HOGENOM" id="CLU_063680_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052514">
        <property type="entry name" value="SAM-dependent_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203">
        <property type="entry name" value="METHYLTRANSFERASE, FKBM FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203:SF15">
        <property type="entry name" value="SLL1173 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="50"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="254" mass="28582" checksum="212F42B8C62EBED7" modified="2013-09-18" version="1">MTTPLQLLETPDGISFYHQGEEEARWIFDEIFTQRCYDTVKLSGKPVIIDAGANIGLYTLFAKKNYPDAQVLAFEPARESGSIFNHNMSLHKLSGVELHECALGSKNETKMLTFFPNTSAFSTICSDGGKELLDLIADKVSNEIADRMRENAREAPVPVRRLSEFLRDRGDITKVDLLKIDIEGGELNVIKGLDEDHLLSVKNIVMELWSPDGQLEAMQKFLEAKGYTVTTTLVPWKSGQAEQLKMYMLTAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ26</accession>
    <name>S0EQ26_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438211.1">
        <property type="nucleotide sequence ID" value="XM_023571151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ26"/>
    <dbReference type="GeneID" id="35407656"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14204"/>
    <dbReference type="HOGENOM" id="CLU_1482097_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT76165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="182" mass="21250" checksum="D6F52842E09D0D0B" modified="2013-09-18" version="1">MGASPDEMISDLTKSSKTTSYLVSVVRCNNPALVGRMRDEEYLHRIDVHQQDQTLRRHLQLDERDLVASPQVTLYAEEFLAQGFPIEDEYDVNHNTINYNDFLVNTFIYMCSITDRIKAELKNTHFYWVVGTRNWTDYYEFTSPIDENIFDPEDELISHIVTMEDQLFLGARILHVRALPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIJ1</accession>
    <name>S0DIJ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable EMP24, component of the COPII-coated vesicles</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_01193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424350.1">
        <property type="nucleotide sequence ID" value="XM_023581462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIJ1"/>
    <dbReference type="STRING" id="1279085.S0DIJ1"/>
    <dbReference type="GeneID" id="35394678"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01193"/>
    <dbReference type="HOGENOM" id="CLU_066963_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494872" evidence="10">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT62269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="203" mass="23277" checksum="2B72A821C10970A9" modified="2013-09-18" version="1">MYFVSAAKALVAAAVFSAVTAHNIVLPAHGRECFHESLHKDDTMTVTFQVGDREFGSAGNLDIDFWITNPAGQYETNEKSISNGDYSFTAKHDGKYIYCFGNENWGANTKEVSFNVHGIVYVSEHEMPADPLDREVRKLSDLLAQVKDEQEYIVMRERTHRNTAESTNSRVKWWNMFVIGVVIGESLFQVWWLRRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIV7</accession>
    <name>S0DIV7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_01358</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with KAR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424202.1">
        <property type="nucleotide sequence ID" value="XM_023579617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIV7"/>
    <dbReference type="STRING" id="1279085.S0DIV7"/>
    <dbReference type="GeneID" id="35394843"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01358"/>
    <dbReference type="HOGENOM" id="CLU_034955_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031884">
        <property type="entry name" value="Sil1_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16782">
        <property type="entry name" value="SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484970" description="Nucleotide exchange factor SIL1" evidence="9">
        <location>
            <begin position="31"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT62121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="418" mass="45739" checksum="99C883EEBDE161BB" modified="2013-09-18" version="1">MAPSRAKSLSLMIALVLGIVLCIFAAPTLASAPATASQPSPEADVELICHTDNPKDCYPKVFQPTDEFQVVHDDQELPHGLHVRLNMSNGKKEAKINVPDEGNPALEGLPVDQAVVVVDQQQQEDPQIPRGAPAYEPIGKIKEPEGEDFVGKPFFTAMKMLKAGETGQGKELDDALEGMEELSHDIYYGLKVTEDPAVLKALFCMMADSDVAYPADITPRDHQAAAILGAALQNNAAALKEITKQWPSLMEGQCPSNSKSLKESFYTPLVPAHVPSSLSTKTLASAAKAKVGAINGLIKSDVIREEFLKNDGMKLLLEVLVPEGKEWDTTQRKVGQLVLDTFLDEDMGAKLGQWPRTERDSDAKCRVFETSTGEGCWDYHVARILKENKRDSGHWSRDLHDRLAALRKSGKVPPRVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJM6</accession>
    <name>S0DJM6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to protein tag-253</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424845.1">
        <property type="nucleotide sequence ID" value="XM_023572674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJM6"/>
    <dbReference type="STRING" id="1279085.S0DJM6"/>
    <dbReference type="GeneID" id="35394137"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00652"/>
    <dbReference type="HOGENOM" id="CLU_038085_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="324" mass="36305" checksum="84E7D715A45901DB" modified="2013-09-18" version="1">MTTTRPAKKAGSWYEEDPETLRLELQSYLTAVPESLDGVPVPVTGARVIIAPHAGYAFSGPCAAWAYKTLDLSRAKRVIVLGPSHTYYLEGCAATTFEKYETPFGDLEIDLELATELEDAVAMEPMDRRGEVNEHSLEMHMPYLYLRCQETFESPDKFPRIVPVLVGSNNRQEEKVIGRALLPYLRDPENAFIISSDFCHWGANFSYLPYSPTKSPSDLTQLRKENPKPNGPPIHETIRVIDEAAMDAVKSGSHDAFLETLKQTRNTVCGRHPIGVVMAALELIRQEDAFQDKGRFNIIKYDRSNLVDIPSQFSVSYVSAYAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK04</accession>
    <name>S0DK04_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424801.1">
        <property type="nucleotide sequence ID" value="XM_023572162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK04"/>
    <dbReference type="GeneID" id="35394183"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00698"/>
    <dbReference type="HOGENOM" id="CLU_067132_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="156"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="309" mass="33528" checksum="A8B59A1664232836" modified="2013-09-18" version="1">MSSIGPQLPPHLSKRKRTPDDEDSNSSKHRRSESPAKNTDEIELEDSDDDYGPSAPLPPKAPVGPALATSNKDEIELESDSESDTGPAPPKPTVGPAPPPADISQRPATSPDSDSDSEDDYGPALPGSAKANKPTIGPQLPSAEPAPQRDSWMLAPPTASGYSERDPTKMRNRKFASKPASSSGPSTVSTMWTETPEEKLKRLQDSVLGRADKNTDTTPKPGKSREEEERNRKIAANIESQRGKSLYAEHQGRREKEGKKEEEEDDPSKRGFDREKDMALGGKIGTAQRRELMNKAADFGGRFSKGSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKC0</accession>
    <name>S0DKC0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425105.1">
        <property type="nucleotide sequence ID" value="XM_023573371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKC0"/>
    <dbReference type="GeneID" id="35393853"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00368"/>
    <dbReference type="HOGENOM" id="CLU_029663_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT63024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="396" mass="42732" checksum="531A094664375DD0" modified="2013-09-18" version="1">MSSHEASTDHSLSGLVNAIVPFIVHSANYLIIPYPRWIVLLIETLPALATKLLMPHVLHRVPYWMRPLTIGAGWIIVAIVTNVTPPNIAPPLRILTSVLASISAAAMEISFLGMLRYYGRVGLAGWGAGVGAGAVFCAILPFVLTVWLESFLRDFIDCIYALTGAMLVAFFVVLPGAPVNYPHAQQEASKVDVEDASLLFQDPVEQLSRMLSTRNRLNLTKALIRPFIWPLFGAFAVQALAYPGIARALPLPTSYTSFFSYFTTYSLAFQLGNFISRTHTLLLRPTSTKAALAIIGASTFILLANSIFLVFSAEVLVGSLAFGAGLGGGAVYMTIFDRVLQETSFESGINLEFGLQVVGVGETAGVIVGGLLGVMLETLMCGGTFTTTKRWCHTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKG8</accession>
    <name>S0DKG8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424996.1">
        <property type="nucleotide sequence ID" value="XM_023573244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKG8"/>
    <dbReference type="STRING" id="1279085.S0DKG8"/>
    <dbReference type="GeneID" id="35393967"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00482"/>
    <dbReference type="HOGENOM" id="CLU_006524_9_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="732" mass="81075" checksum="1771D1320EB4BB07" modified="2013-09-18" version="1">MISSNTDRPKPATAKWGAACAQCSTAKAKCIRSNSTPGSKCDRCERLVKNCTEQVHRPRKKRTVKPSRTAQIEERLNGLVNLLKAGGLTNADLATDTTCIPTEVDPTTADQRKPSTKERDSSLSPETIEWSIPDTYNSYAPPQCICRQTSGVAPPPPASDEELLKLYRKELQALHPFVVIPDGVTAAKLKTTRPFLMSAIRMVTSYRSLRSMRAQMYHLMKYIGDHMLIRSERSLDLLLGIVVIIAWYKYHCFMHAQLNNLIALASTLVGELGLHRSPSVLERTSLMVVTPFQPAARTNEERRALLGVWYLSSSMSLGFLRIEPMRYTKYIQQCLAVLEQEREYDTDMRLVTLVRVQHLTERIAQLNAPDDPAEEVVGLPAAPLSAYVSAFHSELDRIRNGLPPELTNDRVINMFLNTAMLRLYEPPILDAPRIISMSESLTSPTLGAASALDIFYQSRNALKKFFDDWLTVPIPEFYNQTTPVVAQLVYGMTMLGRWAKYTAPIPLTKATTPMPQDTSARDPHDEVYKADSAYSASVSPSVATPSVTTGRDSHETSPISLREGTDPRLPAAVAALRSQIQTQPGLSLDVTGILSAICARFEEANASFQMASTEPGSSDHNLWSMSAIKVKITRAKLERWAEIVAAGTEALKIHDEVRDTAMPDSSTSETGATGFVAATGQDIQHDVFAMPDWNSEMPWASEMLQGVDPSIWFDGYLDWGAVVMNSMGRTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKI8</accession>
    <name>S0DKI8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to nitrogen permease regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424987.1">
        <property type="nucleotide sequence ID" value="XM_023573233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKI8"/>
    <dbReference type="STRING" id="1279085.S0DKI8"/>
    <dbReference type="GeneID" id="35393977"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00492"/>
    <dbReference type="HOGENOM" id="CLU_014995_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="411" mass="46621" checksum="AB39221080A9E97E" modified="2013-09-18" version="1">MIQGIFYARFFPQEGPKIVAQSPAGCITAVEGSTKSPLIDFDVLHEYIIPRQAFCNRYLTINTPDGKYTVLGYPVVIPHTKYLRNEFIFNFGLVLDADVDHVPYERVVRGLASTFSEMEKQNEYLSQNAETKGSGRRPIDSLLEIVKEDLDNYGECMIPVDEANTINMKLFPHHMDPPRVRGWHVPVPKAKFSDIMDPTWDLTLQKVISHIDGVSDVRRIAHAASVSLELAKTALRHLLYYDTILLLDMFFFTACYAPRPGIHDFIRNVDGMVDECAAYVSHGRGLVSNYHLIKLMSTFAPGKSVMEWLKGHQVTGFEVLRFVDVRRFVQFGVIKGCIYRVHKFVVSKQYLAALASGQSRPVPGGDPLQKYTDGCHHFDQIITEQNMTDSEIMEKLKKLPVPKGDLAVFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKM1</accession>
    <name>S0DKM1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425022.1">
        <property type="nucleotide sequence ID" value="XM_023573276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKM1"/>
    <dbReference type="STRING" id="1279085.S0DKM1"/>
    <dbReference type="GeneID" id="35393939"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00454"/>
    <dbReference type="HOGENOM" id="CLU_061601_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="380" mass="43770" checksum="45F8886556620BFF" modified="2013-09-18" version="1">MSSRTSLRSILRGWFASDKYSDSESEPDVRIESARGECPLPDRNRGRHKRERKNPFGLPKKRTYCSHCHGTNGYGDNDFSRGGQQHRLSEQLKPLPVAPRQRPPQARGQRRTPSEDTSLQREGHNQKHKRSNAVDTRPNASKQVNRKKHGIHTLYQQDQDQDQDQGSNEAIFLSDDRSMNREAVSEVVDMIAQRFSHIPYAVSGLAAMVYYGYEARPYRVSIVCPEHTRENQKCWAKAQGMIPIPRQRHVWGVATSDGIIQQIRVRFPYDFNEMHALKIGTAGSNPVSMLSLAGLADELARTYVNELKHSDRDRQENLAHEMIWILKRIIQCRLPEHALRPERIPHLTRETFWLPFTLSYPESVPLFAKAGWSIPNEGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL28</accession>
    <name>S0DL28_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to Protein mmf2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425405.1">
        <property type="nucleotide sequence ID" value="XM_023573736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL28"/>
    <dbReference type="STRING" id="1279085.S0DL28"/>
    <dbReference type="GeneID" id="35393527"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00042"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000004">
        <property type="entry name" value="Translation initiation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF12">
        <property type="entry name" value="TRANSLATION INITIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="116" mass="12659" checksum="292986921A22DFF2" modified="2013-09-18" version="1">MSRQLISSEKFPTKPHNCPATKVPGLVFCAGQTATGEIKQATRTVLQNLKEVLELSGSSLEQVVKYNVYLADMKDFAAMNEVYIDFLPQPMPSRSCLQALPPGDGTVIEIECIAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL69</accession>
    <name>S0DL69_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_01400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424163.1">
        <property type="nucleotide sequence ID" value="XM_023579139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL69"/>
    <dbReference type="STRING" id="1279085.S0DL69"/>
    <dbReference type="GeneID" id="35394885"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01400"/>
    <dbReference type="HOGENOM" id="CLU_042324_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="65"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT62082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="382" mass="42394" checksum="C52A89345C339F31" modified="2013-09-18" version="1">MASFFDLKARKAAAAANGNADQKQDKPSNTRTQPWVEKYRPKTLSDVTAQDHTVDVLQRTLQSSNLPHMLFYGPPGTGKTSTVLALAKELYGPDMIKSRVLELNASDERGISIVREKVKNFARMQLTNPAPGYKDKYPCPPFKIIILDEADSMTQDAQSALRRTMETYSKITRFCLICNYVTRIIDPLASRCSKFRFKSLDQSNAKKRLEEIAEKEGVLLEDGAVDALIKCSEGDLRKAITFLQSAARLVSANAPDKEVEGDEVMDVDKKAVTVKIVEDIAGVIPDTTIDDLVKAMRPRKSGSSYQIISDVVEKLVADGWSAGQVVNQLYQALTYDETIPDAQKNKIVLVFSEVDKRLVDGADEHLSILDLSVRISTIMSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLU5</accession>
    <name>S0DLU5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to immune-responsive protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424438.1">
        <property type="nucleotide sequence ID" value="XM_023582516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLU5"/>
    <dbReference type="STRING" id="1279085.S0DLU5"/>
    <dbReference type="GeneID" id="35394584"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01099"/>
    <dbReference type="HOGENOM" id="CLU_026574_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="291"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="484" mass="52894" checksum="00E9405CD0E3B132" modified="2013-09-18" version="1">MSDSNPKSSSPTVQLSQWVSKLKLDDIPDRVRTRTKYLILDGLACAFVGSHLPWSETAAQAILNLEPTQGDASLIGWGGRKVTALTAALLNGTFIQGFELDDWHSEAPLHSNSIILPALLAAAEQANAQASRFTSPGKDFLLATIAGYETGPRVGRSLWGTHVLSSGWHSGAVFGPAAAAASVSKLYGLDADRIEDAFGIACTQSCGLMSAQFESDVKRMHHGFAARNGLLAVVLAQGGYVGIKKVFEREYGGFLKQFSSGNGKQPQYRPEELTSELGIRWQTDGIRIKPYAAMAGTHPSIDCIRHLQEKHPDRLKRFDEIKKIDILLGEAAFHHGGWKAVKPLTATGAQMSNSFTAATQIVHGQVLMPQFTPEMLVDKDVWRLVDLTECKLHVTDGDSISCQEVRIVFEDGRVLHHGVPNAFGVDPPLSNEDILAKWRQLTKDIVESEVVAKIEEIVLSLEEQDDLVTLFELIRQASKNPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM51</accession>
    <name>S0DM51_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425596.1">
        <property type="nucleotide sequence ID" value="XM_023573667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM51"/>
    <dbReference type="GeneID" id="35393588"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00103"/>
    <dbReference type="HOGENOM" id="CLU_144303_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15304" checksum="9DA0697F684272F3" modified="2013-09-18" version="1">MGNLKPYQHKKNINQIWSVFSIPGKNILIKSEANQQWLVATGTSTKSTGCQKLIHQNPGYCQPTSTGNPHWSDESAQWIIQGGNIHNLNNKTDVSIWNKQYADCVLDVEGGNGPGSPILAYKYHGGPNQIFRLWKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMB4</accession>
    <name>S0DMB4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">FFUJ_05308</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425632.1">
        <property type="nucleotide sequence ID" value="XM_023571302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMB4"/>
    <dbReference type="GeneID" id="35398789"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05308"/>
    <dbReference type="HOGENOM" id="CLU_024516_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="22">
        <location>
            <begin position="61"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCT63551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="531" mass="58210" checksum="CFABB325B6F82D6F" modified="2013-09-18" version="1">MEFKNPNTVTINPVSEQSSSGTNDNGNQLDTHTITPVSDQSNGGSDNRGKKPVPLGIKILAVAIVSMYTFGSRWSNGVTGALKSTLKKKLHISNTQYAILTSTKDIVKLSLILFSGVLTDRYGGASTMLCGTAVDTFGAIMVATATQVRSFKFMIVGSIIESLGEVAISTAQYKILSSWFAPSSGFASSVGIEHGIGKIGSFVAKSTANIIAHNLGLSWAYWMIVFMNLFTNAIALLFWWMTRQCEKRYTHIKDPATGETLTENTKKFQIRKIILLPWSFWLVCLFTMLEDPLSNLFSRNSTELAEQRFNISPSKAGLYSAVSHYSGFFLAPLIGIFIDVFGQRITLMLICGSGLLLSMCLLTWGPTVAGAAASLVIYGIFSSYDSTLITDSLRTSMWYQDIFGSGVAIRSAIKDSMEVIISLIAGVLQDRDDNKYYRVTILYVVLAASCVLVACLMLALGLATDNMGKLQWSRKKRVKNGHVINAKRQESESEGHAEKQRMLNIINFSAVLLLILGAWVSYLWGLVTKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPC7</accession>
    <name>S0DPC7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_00122</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425333.1">
        <property type="nucleotide sequence ID" value="XM_023573645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPC7"/>
    <dbReference type="STRING" id="1279085.S0DPC7"/>
    <dbReference type="GeneID" id="35393607"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00122"/>
    <dbReference type="HOGENOM" id="CLU_434773_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="208"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT63252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="629" mass="72666" checksum="749B1845CCD203E9" modified="2013-09-18" version="1">MPEVEYPDYRLHPWVFQEWLRGRFRDNTIRVECKNACFVFHLPDGEELTEAEICELRGKSSWEKPSSITKFRKWVMQNQRIGLNGFEQTATYVSVSSLKDYWTNARIQEVLELCLIEADIEQIAERFLRTFSLLVQIGRHRDIKIFLDRDFDDETFASPGLAQGRLPDFSDIFEKHWSFFPVEFKSHLTQRQELLSRQILPIKYYELFKKGNRRSESALAKVQIESDYCDLVPKDTPLVFKIYRGDELREDFKVETDNYSNLNGEAQHAVTKCYGSFSCEETDFRVIILEYASEGSLRSFFRNIHPPVSVLEFRELWVNLVGLLDGLEALHTCHDSKQGIHQDIKPDNILVFPKSSESRFDVRFKLTDFHVTEFKHLDREGKMMINNWGSRLYTMPPPGPGKGKEACPGESPASKSKYLALCVQTGPIYTTLKEFDTSSFKSDAALLQEMKSVYTRIRGARSKHNSLFIPIGLEFVKFTLWNQKHGYISICDRPDSVPPKTQLEYDYDPKPLDFLPPMPAQVFLHYLEHGEEGWNKLRYLWLPKLPVRREKRVIEGHEASYGWGIHIIEGPNRWAIFAMLLTTVFGSALAALLWSAIHNDIQGGTGLGQLIIALSSAILTASLFRLGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPF4</accession>
    <name>S0DPF4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_04470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426402.1">
        <property type="nucleotide sequence ID" value="XM_023572240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPF4"/>
    <dbReference type="STRING" id="1279085.S0DPF4"/>
    <dbReference type="GeneID" id="35397951"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04470"/>
    <dbReference type="HOGENOM" id="CLU_028982_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="179"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="9">
        <location>
            <begin position="310"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="504"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT64321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="608" mass="66471" checksum="EBA0C1B742B0E00F" modified="2013-09-18" version="1">MDYSSTIHDVEDPAGDSPWGNSPVSSPSRNNIAAFNPASADAPPPFRYNTQSSNGLSQDQPASQSEEFQRPGTATTASGTEDGTEASGTLNTSEAQSQSTAAEPSAGEDGQSQAHSQQHSQAGAPDSQSGQEQHPPKPAGPQYRLQAKITGLERTGKKDPILRFDVHTNIPRFRTTQFRDVRRLHSEFVKLADHLISANPEVFVPAVPPPLTSAGAGTDEDEIRVKALMQRWLNYVCGNEILMRDDEMVLFVESDFGYSPMVKKKQPATGVRRKILKQFAPPPDDTPELADARPTVKLFYLGSMDAGHKVDKLVKARRGLGLSEADYGAKLTSMHVQEPHPGLANAYRKLGKVVQTVGDYHAAQATAEATTIGDPFQYHSQDAFIVKESLTNRQILIREFLQAQEATRSKLNAADRLKASSSVRREKVDEAITALDDARQHETYLYNKTNRVTQNLVQERRKWFSRTSADLRLSIREYVLREIEAERRTLALLETVRPDIRSIDASGGLSRLGRESHPTVRRSSLAASQGPKGDSWSGVPRRSDATGRSVSGSLISKVSEEGESEESTEAAQGRQTGGRAGLKGVSEEDDEDRVDARNAASRLAASTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPQ6</accession>
    <name>S0DPQ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426512.1">
        <property type="nucleotide sequence ID" value="XM_023572379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPQ6"/>
    <dbReference type="STRING" id="1279085.S0DPQ6"/>
    <dbReference type="GeneID" id="35397827"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04346"/>
    <dbReference type="HOGENOM" id="CLU_014533_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="615" mass="65854" checksum="1C5E01E10D316A28" modified="2013-09-18" version="1">MDRFRNTAGEYEDSATMDDLKAVGYQEVTGLQETQARSPLTKTRSMSDGGGTPSRLSPSPRIVEASRRTSKDDTSIPTPQPVTPRRPNFSNRGFSIQMPPREFTPPAANSYVKPAPLSPKLDHSQIYASPTNILPRRSRGLDFSRAATSLHHSTLAEQSSPDSSPTAGGRAMNIPSRRSHYAGPEQTSTSLWSVMGNQEKMHISSSLGSQAIGSDSSSTSDDDELMDEDMDETYVTTPQVHKIGPILGPQGSGGTFGSPAMSSLMSFQQRQRPRKQAKKKNRGPLGLGFSGASLSKSPPTNSSRARRESISWQANQLHISGADSDETRAMGDVDGLGDGQRNVIRRPKTKGFARIRAALMEESTPAESEFRREAEVVKQVRDCDMELEPRITQPALESTQSTTAPSSPNLTQQEGLNDVPEDDIMGDISMGLSSSFKQHAIKNSKGKTFWDTFSESSSTGGARTTPPPAAFLPRGSSSGISEDVAMDSPSVGGATNGSTQPPTAAEITRRINSKRRRDDDFDPVSFKRRAVSPGMSVHNSPVMQSPLQRDGMSWGSRPGSNGGDKAGSSAPSEAGSTPGNLSGSSSAAGRLNSKGRVGFQGMIDTHDGIMRMSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPV2</accession>
    <name>S0DPV2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426547.1">
        <property type="nucleotide sequence ID" value="XM_023572421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPV2"/>
    <dbReference type="GeneID" id="35397791"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04310"/>
    <dbReference type="HOGENOM" id="CLU_1787018_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="145" mass="15858" checksum="FAC227A1C52F69B0" modified="2013-09-18" version="1">MLQSLLAAEGSGGQRGGSEGAACQISQCNHSTRVTARGINVQNVLHAINYDMPSTTTCHQLRHAINYDMPSTTTCHQLRHAIDYDMPSRCGQQGQLARRRNMTILQRQQGQQGQLARRRNMTILRPVIFVSAGPTSSASLPDIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ43</accession>
    <name>S0DQ43_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to Pdr3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426780.1">
        <property type="nucleotide sequence ID" value="XM_023572703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ43"/>
    <dbReference type="GeneID" id="35397537"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04056"/>
    <dbReference type="HOGENOM" id="CLU_019691_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="543" mass="60786" checksum="16437A0DCFC509B3" modified="2013-09-18" version="1">MSTSQGRKRSRLACETCRDLKRKCDGAQPCGACVRFEYECTYKTSSNKKRKAHEAPLLPSPPVHTEKDSRPSRSDHATSPRHLQSLEANSGAAFLRRLALRLDPKNAPRMHTFSWNAFLGARNSSHVPVSRPITDLLSKEDMESLSAVYFQKMDPIYGFVDRNDISQTIQGRWSGYIYDQSQDSILCGIAAIGCLFSQVEPPPVELDLIETARFILEQKMSDDPSAASVTGWLLRVVYLRIAGTPHTAWMASSILMHMLEAAGLHCEPSQESVLPVTEEKVDAELRRRLFAVAEHLNIWISFDMGRSRTILCNSTLEMPCSREGDYTHELMELLPYSTELDPNKTQDVSELEASLSTVLSRTHSVPPSIMAQTNLSLCLCRRLQSMNTTFSGKILDQILSITKTGIEAAQAILDARSPWHHMANVPFQIICVLLAIDTGESIAQLKDAMQCLSNVATVYNTNATKEALNTASLLILMQQRRKEKCASTLSDVLKTFPIVSLPETRDETPVAEMDDMRWLNNLVGDLSSFDYADLDRFLFPNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQE9</accession>
    <name>S0DQE9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425708.1">
        <property type="nucleotide sequence ID" value="XM_023571397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQE9"/>
    <dbReference type="GeneID" id="35398704"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05223"/>
    <dbReference type="HOGENOM" id="CLU_020425_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="553" mass="62301" checksum="E4CA7778F3783C7B" modified="2013-09-18" version="1">MPSHIALPGAARPRPRFRVNGSNWRWVKKGSTLLFAFFAFTFTVYYLVCSLSLIEAQTDHQIHNDSLWRPTGPILQETEVTPANISSGERKFVIVLPVDDSSPDLCKVVSSAVALGYPAPVIVNWKKDFHTEADGIGPSQLGKITGTLNYLEWATGDEVSSEEKLGEDDLVLMLDAHDIWLQLPPSVMMHRYYSSNERANRRIAEEYGFFDKELMQQTIIAAAQKGCIAPRDKISNLYCNDVPDSTLPENVFGFFTDYTVSRYKYMRPKYVNSGSFMGPAGDMRRYFQRVKDRMDQDLLEVRSAEDLAGDQGIFAEIFGEQELWRRQIKQDDFAGDNPGKEAALSARNEFEYHVGLDYTQELFYPTCYSDYGGAFVSLDDPSTIAKESSQAGVSPPRVGGVPSDISKAEAPFAQLDDHEGGWGDVSLYVDFWTTSVPVAIHHNAWRDGLKARRSTWWDKTWYFPQLRNLIEAHMTANTTTPLASITADDGNLEVWSYGAKTKGSASLLFGKNKDTKAWELRSTDWDTICKASNEAETESRWYDEVFRDGKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS88</accession>
    <name>S0DS88_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427381.1">
        <property type="nucleotide sequence ID" value="XM_023573939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS88"/>
    <dbReference type="GeneID" id="35395715"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02233"/>
    <dbReference type="HOGENOM" id="CLU_1669471_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="158" mass="17544" checksum="BEB37B7A25B5D89A" modified="2013-09-18" version="1">MPTVPVISFCTVGQLGFWKTAIHEMKETYPPLRTGAPRRAPTYMPPFLPAKEAMDEMYRFQSAVYQSIAWLRDHATDAEGIMVLRVIESLAEGQRIETRRIQHRIWILHPARMHREFRDGNFHFVDGEPVMGPDPNANAGANAGANAGGNAAGNAGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSR3</accession>
    <name>S0DSR3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to putative multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_04329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426528.1">
        <property type="nucleotide sequence ID" value="XM_023572398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSR3"/>
    <dbReference type="GeneID" id="35397810"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04329"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT64447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="564" mass="61141" checksum="4E41BED8D7451D40" modified="2013-09-18" version="1">MANTMAEKIEEVAAPLASQDEVQEQHGDKPELSHARKMSILIVMNTVSLVQSFDATCICVVLPSLARELNASFSESLSMGSVFLLATAIAQPIFAEMAHVIGRRPTYVASLVIFIAGTVLCGIAKSSVMLLAGRAVQGVGSGGPQALSGIIHADMFAIRERSRWMSYQHVSWALGTIAGPLIGGAVVQNKDSQWRWIFWCTLPLLGSSLIGAIFLLGYDKGKRNLRLIKNLDWVGILLYIIASVSLLLPLTWGGSRFPWSSAAVIVPLIASFLAFLGLGFYEKTTKKPMFRKSLFRHRSTVLQFASATIHGSLMWMVLYYLAVYFLGIKGQTPLMAGVWALPATITVAPMAAVVGIVAYRTGRYMGFLLGGWALMVAMFGVMTILDKDTPTWVILVMTLFLGIAIGLLIPVMNLGVQATVREEDAGHAISMIYLLRTMGQCMGIAIGIAVFSVQLEKELGKLGLDTAQISNALKMIKASVEHGSLGQQEHMMNAVVKALQCLWMTGSILAGLALILCLFARCPKLPEDPHGPVSAELMPESRFSDTAIGRVWYCFSGKILHKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSV1</accession>
    <name>S0DSV1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_04298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426558.1">
        <property type="nucleotide sequence ID" value="XM_023572434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSV1"/>
    <dbReference type="STRING" id="1279085.S0DSV1"/>
    <dbReference type="GeneID" id="35397779"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04298"/>
    <dbReference type="HOGENOM" id="CLU_010244_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF104">
        <property type="entry name" value="AT-RICH BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="700"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="777"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="805"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="833"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT64477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1072" mass="120797" checksum="621CF9780365B0BF" modified="2013-09-18" version="1">MATDMDHTASLDEILQAFVDNTITLDQPRKRELKNQSDNVDGCANACLDVQIMLLDHIGNSPWTSLPESVQNVLSIKFPGSEYLVLKVQFGVEDLKALPVATPARPQAASAYVTPLSLELPPTGQHAQSPGTADRGSVKRKSAPLLSEALGSLPDLFKKPRLSSPEDDFVPSDDEAPVDLVDDDDAAAATAECLTPVVDDEGFIRIGPQPMKSQLWVQSAPEERSNRIIKEAVAHNHRRTDSCFPNSNADRLELAATKLARELSGLMIESKTGWVKLLCDYTGLPMSWAPGPRSPSLESIYPMVKFEGHIEYHAPPNGCLIMSFINWTKRQHPSIALSLVSVWLNAYQEPNFNSQRRQCAWAFNALSNMMIMTRAFQAMDTHENHIKRWDSRGVDEQRAILEMQRTGTRVPEAERFLEAASVDFLWAPADMLYPARLNFHGSSIYRNLKRIAESKGITTFEFEYYCTVLSPGRIRQRVFYPFHILSRPQAESIGWDWNMLFKLCREMLHTMRTACNKHAEKADRGEAHVDEVQLIYWMGTWVCDQINRLKAEKSDREEIAFSMMLDRWGLPIVPWKSHILRVSLCKKQDHGIAMIFGIEDTPDFDPVQHIDLSCATVTLDTSFTNMAMKNFDTGSWDSLRTILMQVPLHHPFWKVDLSLGDTVWAGEWDRSIQPQAPTPEFQANLLSIEAWVDEQPRDPFACAYCGQTFNSAGRLVEHSRRCSRGIEDEQEAPNLEQDNADQEYWDSTHKCDICNKSFTTARSLTRHKRTHTGDKPYKCDICGRSFTRAKGLKEHIKTHTGQKPHTCDVCGQSFARLDHLNGHKKTHTGEKPHKCDICNKSFTTAQSLKVHKRTHTGEKPYKCDICGGPHRSQTPHHPNPKDWISYREGIVIPGETSTGSGSLVEVGLGEPVEVEAKIPVKTRITLKFSEDETQYPEPVHPAVPRTEGGYYWGYNVRRASSLSNVFTESPYENGYDVSIGTSERGVPASRVFPPSKRVNFNHLIIVFGGPRGLEFAAMNDQELSSMDIQGPRTKELFDHWVNVLPGQGCRNIRTDEAVFIALATLRGIWNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTC2</accession>
    <name>S0DTC2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to ADH5-alcohol dehydrogenase V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_02628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427746.1">
        <property type="nucleotide sequence ID" value="XM_023574382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTC2"/>
    <dbReference type="STRING" id="1279085.S0DTC2"/>
    <dbReference type="GeneID" id="35396110"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02628"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="209"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT65665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="374" mass="40929" checksum="CDCBAB25F6A1772E" modified="2013-09-18" version="1">MTAHVTVPQTMKALRLVEFHKNYTLLHDVPVPKPKLNEALIRVATAGFCHTDLMVYHGITQVSLPFIGSHEPAGTIVALGSDVPGIWHKGDRVGVTNFMDPCQGCNGCKWAMQSLGSLDPRFCDNRTMCGIVRRDGAFAEYMVSWHGAVVSLPDSIGFEQAAPLMCAGATVWHAINQADTTKGETIGIIAIDSHEVGLKLASGVPSHLQPDLVLKLDDPETIQKISDFTDGIGLKATIVCTSDDAASDWAAQRLQPRGILVAAGFPEHGLKFDPMNLILREIFVKGTVHGSMSETREMMEFVVQHGIRSHLTLLTMEEAEDIAAKSEAHAFIGRPVNICLPTHSIRQPYSSEPMEYPVWYLHSDLLKSLAMRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTT7</accession>
    <name>S0DTT7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_04857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426049.1">
        <property type="nucleotide sequence ID" value="XM_023571806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTT7"/>
    <dbReference type="GeneID" id="35398338"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04857"/>
    <dbReference type="HOGENOM" id="CLU_071085_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="227" mass="25068" checksum="28979DE6A3ECF64E" modified="2013-09-18" version="1">MESSQPVVISPQSPSELLSYIISYHRYPSTIIIGSSKEEFQSSLIEEITHHLTLQAEQLQLDDSGDSETQPSHHLLKAPLYQIAISRHIRFLFAPTVTHLRAFLSVFTPKDSPIPAPPNYTPASRPPLLLVYGLLALHRDASEWSAQGIGNSAALLVDAASRNEFRAAIIEPKGIGGHHALDHLGGEMTPLLNGTSRRDDGSWSGRTVSAKQVLSRWFEFDNREQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTX0</accession>
    <name>S0DTX0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_03894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426928.1">
        <property type="nucleotide sequence ID" value="XM_023572883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTX0"/>
    <dbReference type="STRING" id="1279085.S0DTX0"/>
    <dbReference type="GeneID" id="35397375"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03894"/>
    <dbReference type="HOGENOM" id="CLU_010591_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484914" description="LysM domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="249"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT64847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="298" mass="32211" checksum="8380050720C3AA01" modified="2013-09-18" version="1">MHLVAFMAASLAIQLPYALATPHRRDVKCENKTNPLPGQTCAIFAEDWNMTLNEFKALNPGVECPDLDPVGSYCVKGTADKDEPAGVGSKTAKPTSVTEPTEPSYGEMPDAPFDVESFSIPNADDESSAEPTVPQKPSPVDECCGNGIQTPKPIQQGMVANCNKFHYIESTTTCQGVLDRYKISLADFIKWNPAVGEDCTNMWAGTNACVRVKGYTSSATRDIKPNPVADNQSATPSPVQAGLVKNCVKFHYIGPGTTCQEVLHHYKITMAQFAQWNPAVGEDCKTLWKGTYVCVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUF2</accession>
    <name>S0DUF2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to P.glauca late embryogenesis abundant protein and YBR177c and YPL095c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428162.1">
        <property type="nucleotide sequence ID" value="XM_023574883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUF2"/>
    <dbReference type="STRING" id="1279085.S0DUF2"/>
    <dbReference type="GeneID" id="35396560"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03078"/>
    <dbReference type="HOGENOM" id="CLU_032487_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="392" mass="44062" checksum="3EDAD569C1E9036B" modified="2013-09-18" version="1">MEWLGHAELNFTHAPSPRKVQEEDGNVTDLLSICEKATPPCRLNPLLFNGHLQTMWTATKPAGPKIYYKRKIFDADHKIYHGTFAVDFAVEPFEAPDDPSLSRRTAYFTPEEFEHIGSDDCKPMLVVLHGLSGGSHEIYLRHTIAPLIGEGGWEVCVVNSRGCARSKITSGVLYNARATWDIRQEGPNCVLKGAVVCSNPFNLEVSSKILQNSYIGKEVYLRVMGSALKELAATHRTELEKYSKIDVKAVMNITYLYEFDRLIQCPSWGYPTESAYYRDASSVDSILSIEIPFLAVHSTDDPIAVKEAIPYEEFKQNPNTVLLTSSLGGHLCWFETSGDRWFTKPVANFLNHLAFKTDLNDLRPLANPNNNDHLADGHGYIPMRRKLVIVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUF8</accession>
    <name>S0DUF8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to bromodomain and PHD finger-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_03229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428300.1">
        <property type="nucleotide sequence ID" value="XM_023575053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUF8"/>
    <dbReference type="STRING" id="1279085.S0DUF8"/>
    <dbReference type="GeneID" id="35396711"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03229"/>
    <dbReference type="HOGENOM" id="CLU_002663_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15670">
        <property type="entry name" value="ePHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="428"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="482"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="646"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="979"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1126"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="761"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="979"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1144"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT66219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1158" mass="127731" checksum="F9796D9BFF013993" modified="2013-09-18" version="1">MAPASPTPRRPVTGRRRGRPPGSTNAARAARAALAAASATEPPPKRRRYIPGGAGGGGRFADADLLTTPNTTGPPTVSRSRAAAREAINGPSPSIMPRRERGARTRAAGNDGLEEMQWGSAAAMATAVKQAEDYKPREERSWEDFHPNLDIDATFMILRSEQVDGIPQEQPDSSVVQAFGTPLDETRTPSRQPNPASTGNTPNPQGRSDSNAADVLGETPLRRPRRPTRDVVSFYSSKPLDFLSTPKTPKILPIQNQTPKEKLDLKLPSYRKTNSIELYESKTFGQARFVDKSMSNVGYQESDHYLRPEQALIKSSDLTMEDDAELTDAAMAASDGPVHRTRIGRVEYDMDEQDDIWLGRYNTHRKQNDVPAITREIFEITMTKIEKEWHVLEKRIPKPNPKPPQTHRPRSSSAAAVNGEPQGGEEPDSKCAICDDGDCENTNAIVFCDGCNLAVHQECYGVPFIPEGQWLCRKCQLCGPSVPTCIFCPNTDGAFKQTNSSKWAHLLCAMWIPEVSLGNHTFMEPVMDVEKVPKSRWKLTCYICRQRMGACIQCGNKNCYQAFHVTCARRSRLFLKMKTSQGALAVLDGGMVLKAFCDKHCPPDYVQEHSVQQATKAAKKFYKRTMRNRIWADNTAVANAIAEQQRNALSEKPSDETQVTGTKSAAVGDKKRGQNPKNVWKTPAGAPIIPQAVFEVVDASIQRFALPKRKEFLSQACRYWTLKRENRRGAALLKRLQLQMESFSSMELTRRDFAAMGPSGKIRLARRIEFAENLIIELEQLKDLAAELVEREQIKVAACELEQEFVDECYFPVAKLLNPAVDRAISLDKDLFKDGLDKLQSRVNARFYVTVMSFALDLCDVISTGISTAPPESSTVATQTEVVDASLAKTTFSDIRERRKLGKRILKAVQPHLETALRIESEISQKPFEGLKKELENIIDRSVDIRPLTATSQDKPTDLSDEANDTIMVDAELQITVKASSTEGGDAMDTTSDNGNIEVSTNIDVDTSDLAEAGAVGKHESLPNTINSSNTPPDTDGYVSKPQPAQSGPPTPPQSNGSLGLEPADPLTDGGILWYLKGHDPKGTSVLEERWAGRDAIRMLSEDLTDLDDEEFKGLGMDVDHAAASATVEADVQEEVEPAGGKTRASKAKKRRTSTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUM9</accession>
    <name>S0DUM9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_03135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428216.1">
        <property type="nucleotide sequence ID" value="XM_023574948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUM9"/>
    <dbReference type="STRING" id="1279085.S0DUM9"/>
    <dbReference type="GeneID" id="35396617"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03135"/>
    <dbReference type="HOGENOM" id="CLU_051065_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT66135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="264" mass="30312" checksum="312B9C477B0810F9" modified="2013-09-18" version="1">MAPSPTEKKDEAQQIDNMSKAQDRMARFKALQARAKTSSEKNLKEATLESQRLATDPSQLTALHRKHAIASHKLLKADVEEAGGDFERKRAWDWTVDESEKWDKRLKKKTTRRDNNAFADHTQEANKIYKRQLKNIDTNMEQYEKDKKALIEKAAASGGLDIVETEDGELIAVDKDGSFYSTADSTTFAENKPDKAAVDRLVADLQRAEEQRLKKRKERMAQNGDDGDVTYINEKNKQFNQKLSRFYNKYTAEIRDSFERGTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV31</accession>
    <name>S0DV31_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427333.1">
        <property type="nucleotide sequence ID" value="XM_023573886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV31"/>
    <dbReference type="GeneID" id="35395667"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02185"/>
    <dbReference type="HOGENOM" id="CLU_075610_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="269" mass="31059" checksum="7F133295113309E3" modified="2013-09-18" version="1">MTVIHTLEAKALAKDEAHRKRLEEEVERRKAQEQDRSRGENVWFSRRIKDGHLYHWALFVYGKKYELRLPSRQKYKSLPKGHLVGSLVPSIDYESKIAPWSMQDEMMRLRQESLDSEGKPYAQDYYICQIGWTKMSEKRVDEECEAAHKSFGVYVLGFNDCQSFLRQFAKRIIKQPEDCALDFPWFEKNIQTAYHELQLIAADENIKAFQFYMRTVLYGTAGATVVGAGSAYEHQYQSQEPMTKANGSKEGSKKDDDDDGCCDCDGCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVS3</accession>
    <name>S0DVS3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428641.1">
        <property type="nucleotide sequence ID" value="XM_023575463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVS3"/>
    <dbReference type="STRING" id="1279085.S0DVS3"/>
    <dbReference type="GeneID" id="35397079"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03597"/>
    <dbReference type="HOGENOM" id="CLU_030583_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485330" description="PA14 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="248"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="428" mass="43975" checksum="2FE0FBD73E91F342" modified="2013-09-18" version="1">MKSVLTFAGLAFASFAAAGPCRPRTTTTAAAVSSSTEIASSTATETAAVSTSTGYSVPVVSESSTTLATVIVSETSATETSAGETSATGTTTAETSAAGTTTADTSAVDTTTTAADTTTTVEGTTTTVADTTTAAEDTTTTAADTTTTAEGTTTAEGTTTEGTTTAAETTTTAEGTTTTAEDTTTAETTTAEGTTTAADTTTTAEGTTTTAEGTTTADATTSTSAEPTADQSCDNAGLEYAIYKHTFYNSDPPHFSSFDPTFFHTATPTYQGETTRIGIPPGTASDTSFAIYDGSPSQLWQYKAVNHRAFLYAPETGDYTVTIPNSDEITLIWFGEKAIEGWTRANADLEQDYPGGTSKTFTIHLTAGTYTPFRLLWANAQGDLNFIAEVQAPDGKVIVNGDGSDNKYFVRFACDESTPSFPDFGYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWB2</accession>
    <name>S0DWB2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427758.1">
        <property type="nucleotide sequence ID" value="XM_023574397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWB2"/>
    <dbReference type="STRING" id="1279085.S0DWB2"/>
    <dbReference type="GeneID" id="35396123"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02641"/>
    <dbReference type="HOGENOM" id="CLU_051898_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT65677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="259" mass="29090" checksum="A80B78CDAE8DF015" modified="2013-09-18" version="1">MADNVMAAYWALPPVSRNLITATVLTSIGCIVGLLPATRLIYHPSYLWMFPPQIWRLVTCFFIEMQPINLLFNSFFLYRYSVQLEMGNPRFPRKVDLVFYILFVCTVILMIDYLAGLTSFLYMNGLILAMIYTTTQDQRGQKTQYLVLTIPAQALPICMIVVTALMAGPQKALVEIEGLLAAHLFDFLTRIWPEFGNGPRLLRTPAWLERLVQTPRITARGFGTAVRPGNSPSSGRSTGINTGPLPDSWRSRGPGQRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXQ6</accession>
    <name>S0DXQ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428233.1">
        <property type="nucleotide sequence ID" value="XM_023574967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXQ6"/>
    <dbReference type="STRING" id="1279085.S0DXQ6"/>
    <dbReference type="GeneID" id="35396634"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03152"/>
    <dbReference type="HOGENOM" id="CLU_020826_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="408" mass="43876" checksum="5A6920DC953CDE7C" modified="2013-09-18" version="1">MKKTLLLCFIHGFKGGEDTFGVDYQFTKDLRDLVGQALPKVDVEVVVYPKYETRGDLGSCVSRFRDWLQNKVIDMEVAAGTPSPTIEPSVRTILVGHSMGGIVAAEMLIGLASEKPIYTEDGIQKTEKPTFNSLMFPYIQGVLAFDTPYLGISPGVVAHGAEDQYQNAAQAVGAISQLSGLGASLWGAKAAGSPSTSPAPPKIAGALPAPSTSGGNSWQKWGKMAMYAGAAGAVAAGGAAAWMKRDQLGEGWSWASSHLEFVGCLARGEELRKRVACLLQLREELDVGFANIYTRLGKAAPSKQINVVGTVLGQDRTFCNLPKKQPGGVWMEAINNKATDEAGAHMNMFTPRENPEYNRLAQDATEVIRGWLQNGWYETSAEEPLLLEDTPLTEDGLLPETPQVEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY42</accession>
    <name>S0DY42_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to light induced alcohol dehydrogenase Bli-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427459.1">
        <property type="nucleotide sequence ID" value="XM_023574033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY42"/>
    <dbReference type="STRING" id="1279085.S0DY42"/>
    <dbReference type="GeneID" id="35395799"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02317"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF281">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="291" mass="32597" checksum="33EA6EDC30FF9712" modified="2013-09-18" version="1">MINRKEEQGQEAISTIQSEKSDAKVDWKECDMGNLAQIREVFGGLRESLDRLDFLVLSAGINTNQFGLDSDGIERHFGVNFLGHFYVCNQLWPLLRKTGKMENTPPPRVVFEASEMHRLAQLSNIQFRSKDEINDPNLDSTARYNRTKLAMILFAKYGLAGKVIQENGDRIYALSVHPGAVNTAMQQQWKDAYPGLTGKLLSWAMLAIGRDVEQGSYSALWALTSPKIEEEDLNGYYFSDPDQEGKETSQASNPELATNLWNLSSTLIEGVLGSDALLDWNVSTVADKDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYR0</accession>
    <name>S0DYR0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein PTH11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_14685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429777.1">
        <property type="nucleotide sequence ID" value="XM_023576646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYR0"/>
    <dbReference type="GeneID" id="35408065"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14685"/>
    <dbReference type="HOGENOM" id="CLU_019101_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT67696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="369" mass="42128" checksum="904CDDF271913C0C" modified="2013-09-18" version="1">MTALAGQIAEIWILYVIGTAMIGARIFCRTKMVGYRNYDWDDYLVIAVAGMWTAAPVIGQVFVQGAEGRHTSDLTFEERKNMSEEDRKKWAYGSQMFLLGLTGYVVILWTLKFNMLCFYSRVVRGLWTERFVKPLMVVVILSVVVIIITLAATCRPFHHLWQVWPDPGRQCVPQNLTFFVVILVFNLVTDICIMLIPIPVLVGIQTNRLKKFGLILLFSLGFFCMFAAILRFVLIFNASVSALWSMREDCVGIFVGQAPMVTPLLKRRFWVMAGYATDKTGNSQTPHYNGSRLESHELRSGRANNSKVHDPYSITNVVSRSESQEEIVQKDLPSLPEQPRQFRSGIRVEQRIDVEAVQGTYTQPRDPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYR6</accession>
    <name>S0DYR6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable zinc-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_14738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429815.1">
        <property type="nucleotide sequence ID" value="XM_023576705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYR6"/>
    <dbReference type="STRING" id="1279085.S0DYR6"/>
    <dbReference type="GeneID" id="35408118"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14738"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08286">
        <property type="entry name" value="FDH_like_ADH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF4">
        <property type="entry name" value="NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="8"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="345" mass="36138" checksum="9622600C5AD078D9" modified="2013-09-18" version="1">MKALVYAGNGSVTLQDRPVPKIASPTDAIIKVTKTTICGTDLHIRKGDVATCEPGRVLGHEGVGIVHSAGPSVARFKEGDKVLISCISSCATCEYCRRGMYSHCTSGGWILGNTIDGTQAEYVRIPHADSSLHPIPDGADEAALVMVSDIFPTGLEVGVLSGKVQPGGTVVVVGAGPVGLAAIITAQLYSPSRIIAVDMDNARLDVAKKLGATEAVVSGPDTVAQVMKLTDGKGCDTVIEAVGIPATFELCQKLIAVGGVLANVGVHGTKVDLHLQDLWIKNISITTQLVDTVTTPMLLKLVQSGKLQPSQLITHNFKLSDVENAYKTFGEASKHNALKVLIEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYZ9</accession>
    <name>S0DYZ9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_14802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429862.1">
        <property type="nucleotide sequence ID" value="XM_023576788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYZ9"/>
    <dbReference type="STRING" id="1279085.S0DYZ9"/>
    <dbReference type="GeneID" id="35408181"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14802"/>
    <dbReference type="HOGENOM" id="CLU_014095_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="649" mass="72680" checksum="A6879372CD16C2B9" modified="2013-09-18" version="1">MNDSPQRTPNIPRYPNAPRTEAAATQPPDLKSILRVRQLARIRKACLPCRERKVRCNHQQPCQTCIKRRHSDLCFYDQSRASSSPTPQPRQPEVQAITDSSHGTNNATQPRRPVSHDGSASNASPSLLGDNSIISVARPDTTQPHANNERRTAFETGILPLLGMDGASDGGRGTPAGSSETIFAVDQDMISLFGFYRDRVHSFQFVLDDLTEIEKLICSLLSHEVQTQQIDNHSLCLLHAIMAAGAQFSDLPTAIRLSKSSQNLQSALKYLGSFDLLWNPSKRLIQALLILGHVLQNNMNPRAAWILGGTTVRVALSVGLHQPINHCALRLSPAEAQQLRLAIVWQDALLSLAFDRPPASHEMDLEPDLPALVSLDPSSQPLDYRQAMNWLCHLSFRHLPRLPQTEPVRDYSRLFHDFDLYESSLAPHLQDLQRSTSIQELQEHYSLIVHRYFLLSTLCRPVLSSQNKGKFSEEECSTILNRFQGALKQSVRAFIKLRSISNLATRSWAFVHNGLASALLLSFIRQGSDAQDQDSQEILAELVKTLTERSDDVGQFSAAHKKALRAIQALQRSSVDEIRCQSENSSQEHHPIAVSSENMPVLPEHFGNTQEQSMVSLDDWLRDFDFDAFSPLESYNFIMSDQVPQDFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZL4</accession>
    <name>S0DZL4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429926.1">
        <property type="nucleotide sequence ID" value="XM_023576522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZL4"/>
    <dbReference type="GeneID" id="35407954"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14573"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="30"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="447" mass="48192" checksum="59B6ABABEF47BB73" modified="2013-09-18" version="1">MNAKGTPRQPDLETQEISPTSEKAPDGGYGWIVTTSVAIVNGHSWGINAAYSVFLAHFVKENTFPGTAPLIYAIAGSLSVGAMMLISPFATIVARELGTRPTMLIGAIVQSVSLVFASLSIEIWQLFLSQGALFGIGMGLLFLPSYGIISQWFTRRRALANGIAIAGAGLGGLTYSLATGAIIRNMGLEWAYRILAIVSAVANISCTLLIRTRYNAQAMRLAFDTTLLHRPEYLLVLSYGAFSILGYFVLIFTLANYANVIGLSSSQASMIPAFFMFGQAIGRPCIGWLSDRFGRINLTFIMSLITGILTFAIWINAKSFGVLLTFALVGGLSAGVFWVNISPVLVEVMGLENLASALSCLWVAMAAPSTFSAPIALEIYTGTGSYLGAQLFTGFMYIAASFCILGVRHWKIKSLRSAKERSRAPGEEGEDSERKGWAMRLTKFEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZT2</accession>
    <name>S0DZT2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_06781</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430106.1">
        <property type="nucleotide sequence ID" value="XM_023576959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZT2"/>
    <dbReference type="STRING" id="1279085.S0DZT2"/>
    <dbReference type="GeneID" id="35400258"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06781"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="34"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="224"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT68026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="385" mass="42048" checksum="ED35F2DE4CE8C9A6" modified="2013-09-18" version="1">MTTDYKFEGWMGEDERSAEGNMVWQEYEPKKWEETDIDICITHCGICGSDIHVLRSGWVSLYEAYCYTARLINDFVPQRQAPYPVVVGHEIVGVAVRVGSQAEGGIKVGDIVGVGAQSDACLNRKLGDDNNGRPKCNECASGEENYCTRMAPTYGSKFLSTGDKTQGGYARYHRCPSHFVFRIPEGVAPEYAAPLLCGGVTVYSPLKQFGAGPGKKVGIVGVGGLGHFAVLFARALGADEVVGISRRESKRQEAMDLGCTDYIATADEEGWETRHSRRLDLIISTVSSPKMPLADYIGLLRLDGTLVQVGLPEGQLPFRPGSLTGARRRIAGSSIGSPAEIKEMLQLVADKNVKPWVEMRPMSDANQAIVDFEAGKPRFRYVLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E005</accession>
    <name>S0E005_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_06731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT67980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430060.1">
        <property type="nucleotide sequence ID" value="XM_023576903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E005"/>
    <dbReference type="STRING" id="1279085.S0E005"/>
    <dbReference type="GeneID" id="35400208"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06731"/>
    <dbReference type="HOGENOM" id="CLU_038125_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484685" description="Alginate lyase domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="111"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="411" mass="45979" checksum="5C40E738065321A8" modified="2013-09-18" version="1">MKLQFLMLGLGASFALKSVHAASDSNATPYLPIPTKAPKTWVHPGVFVSGPQLNYIAKRIKARENPWTEALDSMLNMTYMSPTRTAEPYETVQCGPTSTPNIGCYQEREDSMAAYMNALAWWITKDKHYAEKSIHYMDAWSSTIQAHNNSNAPLQTAWSAANWVRAGEIMRSSYKHWSKKGIKMFSDMLRHAYLPMIEDGAPRKNGNWELVMIESTIGAAVFLEDAALYEKALGLFSARVPAYIYLTSDGEYPVQGRGGINTTAEIIKYWYNQKTFPISGITQETCRDFAHTSFGISSISHIAETMRIQGMDVWRSTDVGARVKAALELHTALDSKQKPVPKWLCNGTIPDTMNPMLEPAYNALAFNLGHKMPFTKKVLLSQRPAGISEPPLFIGVETLSNAQTPFERWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E094</accession>
    <name>S0E094_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to glutathione S-transferase GST-6.0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430316.1">
        <property type="nucleotide sequence ID" value="XM_023577211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E094"/>
    <dbReference type="STRING" id="1279085.S0E094"/>
    <dbReference type="GeneID" id="35400484"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07007"/>
    <dbReference type="HOGENOM" id="CLU_011226_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03188">
        <property type="entry name" value="GST_C_Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03057">
        <property type="entry name" value="GST_N_Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="103"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="230" mass="26190" checksum="3FCFDFBE5188B59F" modified="2013-09-18" version="1">MGSTTESINMPKLTLYRANGSCSLIPHAILRHYKIPFTAVRLKFGPNGVEAVDGSFSNAQYRSIHPRGYVPALTTDDEVITEMPAILSYISSLVPEEKLFGIGTVQQAKVLEWLVFLSGTLHGLGYGAWLRPGRFSDDVADHKRIRAKGREVIHESFKRIDDALKNREYIVGNALTFVDFNVYIFARWAHELEIDLEREYSHYYEHVRKIERMKGVIEAVENEGLKFAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1R3</accession>
    <name>S0E1R3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to endoglucanase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429678.1">
        <property type="nucleotide sequence ID" value="XM_023576478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1R3"/>
    <dbReference type="STRING" id="1279085.S0E1R3"/>
    <dbReference type="GeneID" id="35407914"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14533"/>
    <dbReference type="HOGENOM" id="CLU_073364_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="328" mass="36115" checksum="C175034DCE4A5EB5" modified="2013-09-18" version="1">MTIRFLVNFGLLALPIAITLGVLIGLNSSREASGGPPLFKPDPKPTAPKKKNGITTEQHCQKSYGVHPDTKGQEYTLNPNQWGWDEGDDGGLCLYVDINNNETYATKTTAPRWSVVWEYPQGPETAPVHAFPNIKVDGDVFPAKLNTIDKIEIDFEWTYALGNGSAKVATQATKTDLAAMKKNLLNANVAMDMFMDSDQKKAQDSADASHEIMVWFAAIGPATQPIGFDVDGANPLATKTLHGTEFKLYYGTNQAKQKVLTWYVDEPTEKFDGDLYPLVEEILSMDNANYPTSSYYIGYMSWGTEAYSANTTVTFDVPSLSINVEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1X2</accession>
    <name>S0E1X2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430780.1">
        <property type="nucleotide sequence ID" value="XM_023577768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1X2"/>
    <dbReference type="STRING" id="1279085.S0E1X2"/>
    <dbReference type="GeneID" id="35400985"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07508"/>
    <dbReference type="HOGENOM" id="CLU_104756_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485504" description="GPI anchored serine-threonine rich protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="16828" checksum="8BDF3F288E54732E" modified="2013-09-18" version="1">MKFLWSLALFAAAASAQSSTDSGAAPSASSECEAEYIVKRCLETENAKVEACKANDWDCLCASYEAVATCFNNCPDDSRASSAQSQVQVNCQQASLYGTATKATKTSSSTATADASDATATGSDAPDATSSATESAASAENTNNAADKARNTAGVLLAVAGVVAAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2K6</accession>
    <name>S0E2K6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to nucleotide exsicion repair protein RAD7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428999.1">
        <property type="nucleotide sequence ID" value="XM_023575731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2K6"/>
    <dbReference type="STRING" id="1279085.S0E2K6"/>
    <dbReference type="GeneID" id="35406543"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13087"/>
    <dbReference type="HOGENOM" id="CLU_006598_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000601">
        <property type="entry name" value="DNA repair protein Rad7, protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000632">
        <property type="entry name" value="DNA repair protein Rad7, protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056451">
        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF234">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23550">
        <property type="entry name" value="zf_Tbcl_Rhp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein rhp7 treble clef" evidence="2">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="600" mass="67468" checksum="70A7C6244BF59679" modified="2013-09-18" version="1">MVSKINLIDKLVLSMDPLTDFLASHNISAAQIRSDADARRRQAARDDVAEDENGNGESSAAGARSGRRSSRNDNDEASLKRKREEEKKLAKIKESKAFKKRKQRSDLSDDELARALMESNSGPLPGQIEHCEICEKRFTVSPYSLAGPNGGLLCPPCGREVAKEREGNQKKKPKKPANTGPVGRRRAIQSRILDGDVGTKSLATLCVQTLAKNVDLADSLGDLPDHLVDKIARMFSKRRLLKPETLPLFVQPGTEDLHIYDGAKLGEQDYISIFQTASKLKNLKIRCGIQFKDEVMDYLLSRDINLETFYLHGANLLSDEKWHKFIQEKGEKLKGIQVYYTDNHFGDEIIATLRDHCPNLKRLKVENNQKLTNDGVKTIASLSSLEHLGLQLQHKTESDAYIEVVSKIGANLKTFSLKIVPEVDDTLLQAIHEHCRSLSKFRITDSEFMTDQGFVDLFTKWANPPLRFVDLQKCRQIDASKPRENPDSVGLCSEGFKALMAHSGEKLQYLNIHACRHISREAFEEVFHEDAQYPELKELEISFCEEVTDFILGSIFRSCPKIREVNVFGCMKVKEVRVPRGVILVGVPNAQGMMVEGSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2P4</accession>
    <name>S0E2P4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to cytochrome c oxidase assembly factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431141.1">
        <property type="nucleotide sequence ID" value="XM_023578312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2P4"/>
    <dbReference type="STRING" id="1279085.S0E2P4"/>
    <dbReference type="GeneID" id="35401474"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07997"/>
    <dbReference type="HOGENOM" id="CLU_161486_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495486" evidence="5">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="85" mass="9813" checksum="1F6EDFBD72C89ACF" modified="2013-09-18" version="1">MSRASKLTLLGTSLLTVCTVVGVHFQQKFEQAAMHEGVVRDMEQQRIKRERQLDFDLQKQLEAEYKREQTVHDSIEAADKGLPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E353</accession>
    <name>S0E353_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to thermophilic desulfurizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431165.1">
        <property type="nucleotide sequence ID" value="XM_023578341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E353"/>
    <dbReference type="STRING" id="1279085.S0E353"/>
    <dbReference type="GeneID" id="35401498"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08021"/>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="39"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="474" mass="52414" checksum="5C08BAA175FDD881" modified="2013-09-18" version="1">MSESQDAPKAKKQLIINAFVESCSGHQSPGLWRHPDDKSWDFNNISHWVKLAQLLEKGKFHGIFIADVLGSYDVYKGPRNPDPAIISGAQWPVNEPLATVPAMAAATKNIGFGVTVATTYEQPYHLARRLSTVDHLTGGRLGWNIVTGYLDSAARNLGHTEQPSHDERYAIAEEYVDVTYKLWQSSWRDDAVKLDREKGIYTDPCLVRLINHEGKYYTVPGPHICQPSPQRTPVILQAGTSKAGKNFAAKHAEAIFVAGHSPVTVAKNIAEIRTLAKEQFGRDPKAIKFLALFCPIIGKTQEEAEAKYKELVSYGSEDGALALFGGWTGIDLAQYGDDEELRYVESNAIRSAVESWSKSIPGVPKWTKHTVANHIKVGGLGATVAGTPERIADEMERWVNEADVDGFNLAYALMPASFEEVISDLLPVLRERGLFWEDYAVDGGTYRENVYGKKGVARPPADHPAAKYHWAKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3K1</accession>
    <name>S0E3K1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_07868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431489.1">
        <property type="nucleotide sequence ID" value="XM_023578169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3K1"/>
    <dbReference type="STRING" id="1279085.S0E3K1"/>
    <dbReference type="GeneID" id="35401345"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07868"/>
    <dbReference type="HOGENOM" id="CLU_013933_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="558" mass="62609" checksum="A0C98FD2A2CB3B87" modified="2013-09-18" version="1">MDVAQAVSGYINKVVTTSDTSSAKMKILLLDRETVSIVSTAVTQSSLLNHEVYLIDRLDNAAREKMRHLRCLSFVRPSPESIQLLIDELRDPKYGEYHLYFTNVVKKSSLERLAEADDHEVVKLVQEHFADYNVINPDLFSFSFTLPQQRIWAGSPDTWNPDSLQRCSEGLVAVLLSLKKKPLIRYQKTSPLAKKLASEVRYLMTQEDSLFDFRKVDTPPILLVLDRREDPVTPLLTQWTYQAMVHHLLGIQNGRVDLSDVPDISPEQKEIVLSQDQDPFFKKNMFLNFGDLGGNIKEYVGQFQSKTKNNENIESISDMKRFIEEYPEFRKLSGNVSKHVTLVSELSRRVAADNLLENIQRLIQSPNVTPESKVGLVALYALRYHKHPSNTLPMLQDLLVAAGNVSPREADLVSKVTAYHNSLQASQSQGGISEIFESAGIFSGTGSRFKGLKGVENVYTQHSPLLETTLQNLIKGRLKDQQYPFVEGGGTTKDKPQDIIVFIVGGATYEEAKMIAELNASSPGVRVVLGGTIIHNSATFLEEVDDAVSSWPESRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3L7</accession>
    <name>S0E3L7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to 6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430322.1">
        <property type="nucleotide sequence ID" value="XM_023577218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3L7"/>
    <dbReference type="STRING" id="1279085.S0E3L7"/>
    <dbReference type="GeneID" id="35400490"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07013"/>
    <dbReference type="HOGENOM" id="CLU_018354_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF7">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT68242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="466" mass="50890" checksum="24B168AD71C172B7" modified="2013-09-18" version="1">MPAQIKGIELLQCEYVVPDNDAPQLPRWSDTHIEHPALTVTPKTEQDVKDAISIAKENKLTIVAAGGGHGTFVSVDSASLYLDMKLFKKIELNKDEGTVKIGGGVIVGEVLKTLADEGYYTPIPNSDAVGFVGCMLGGGNSAQTGLHGWMVDNMVSFRLVASSGDVVEVNSSSKDKEQALFNVLCGAGHGLGVVTELTVSAFSLSSINMDDDKIWTRSLIFPAPALDVAIKTFLSLSHPPAEGYMSLAFARSPPGTPAAGSPIIILGYQYFGPAEQAEKATALLFQDDIVSKTVVANTELLLFENINAKMNIYNSHHGHKTIASCRLHKTTAEAIKAGFNKWRIATEDYPDAQQSSLIISSYNTDKTSAIKDEKFVEGRDRNINAFMVMVAKEDKTREAFGPILDDVVAGFRKIDEGRVPRSFPNNLRPGKDLSDMYDEERLEVLRDVKKTWDAEGVFWSPYFKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3U8</accession>
    <name>S0E3U8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_07119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430422.1">
        <property type="nucleotide sequence ID" value="XM_023577335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3U8"/>
    <dbReference type="STRING" id="1279085.S0E3U8"/>
    <dbReference type="GeneID" id="35400596"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07119"/>
    <dbReference type="HOGENOM" id="CLU_115008_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="123" mass="13901" checksum="923F1E14841ED5A8" modified="2013-09-18" version="1">MSRTPSLFNCLIRTHHITSRKKLSRVRRAAQQLNVDWLYVRSGGSPGIMFAEGRDEAGLTEWVSTVQALRYKDFKCVAKPARAEGVGSKSGFDETESVREFGRVMDERGLGGWWKRAMGYEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3V4</accession>
    <name>S0E3V4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to synaptic vesicle transporter SV2 (Major facilitator superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_05400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431589.1">
        <property type="nucleotide sequence ID" value="XM_023578607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3V4"/>
    <dbReference type="GeneID" id="35398879"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05400"/>
    <dbReference type="HOGENOM" id="CLU_001265_52_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="64"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT69509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="525" mass="56550" checksum="158B179A99120194" modified="2013-09-18" version="1">MSNIEASGSVKESRDQEKDGMAADDVSYHVSTVNELGNVVDPVLSAKINLVNETINEIGWTNFHLKLCCLTGFGFAADSLVAFLQSVAAGQAYLEIGHGGYPTGSTMALYAGLQMGALFWGFGADIIGRRIAFNTTLFIAAIATIVAGAGPSWVAFCVFVAFLGFGAGGNLVLDPTVMLEFVPAKQQWVITAMAGWWGIGQASAGFIAWGYYSRNDWTCVATVETCTWQNNKSWRLIMFTGGALMFVMSALRILIIRLPETPKFLVTNGKEEELVAMLQKLASTYKRPCSLTLEGLQACGTAHIPEHGGSKGLAVRGLGKSLVGHVKGLFSTKKLALSTCLIWLSWTLIGLGYPLFFLYLPSLLSSRLPDYKPSFTETWRDYTITNICAIFGPLIAAGLAEVGFLGRRYTMAIGAVITAIFFFCYTIIKTPAQNLAISSCISVCINLYYGTLYAYTAEVFPSEHRTTGNGIAVSLNRIMGLLSAVIAVTADTTTIAPLYISGALFFVMAIVSVILPFEPYGRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3X0</accession>
    <name>S0E3X0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_07884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431465.1">
        <property type="nucleotide sequence ID" value="XM_023578187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3X0"/>
    <dbReference type="STRING" id="1279085.S0E3X0"/>
    <dbReference type="GeneID" id="35401361"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07884"/>
    <dbReference type="HOGENOM" id="CLU_141397_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT69385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="113" mass="13088" checksum="1B6B86D179EC19F0" modified="2013-09-18" version="1">MSAQQLSIDNADLEKLNDKDRLELRQFLANEQQRSQIQARTYNTEEDIMGYGIADEMSLETHSLTQMCWTKCVPGNIKNPKLDKSEETCLANCVERFLDVNYLTMKHLNGMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4G2</accession>
    <name>S0E4G2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-glycosylation protein EOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431859.1">
        <property type="nucleotide sequence ID" value="XM_023578934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4G2"/>
    <dbReference type="GeneID" id="35399173"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05694"/>
    <dbReference type="HOGENOM" id="CLU_043164_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31624" checksum="43142C830CC17A23" modified="2013-09-18" version="1">MANPPPVRRGSSTGHLPLPPQPLAPVTSTSSKPPPPPHTAKTAPPEIDSPVHPSLLQPRVAVVLNVPKPWHPWLFALRLFSILPALWWGLPSALQLLLRVLPGPEIVVVVPSTTGGSVAMSVEADARYALTETGLATIWCFASGYLSFFFTDCLMSRWLINYTPQATMVRLLTTNFCNAYLTAFVLSFTGGFQDPRLLLPGWVGIATTLTMMYHVTHQKINIRKETSTSINVFSIACSITMVTLLVHLHQSTPDYPQMPIVASGRRAFDEASRVITQIRGSIEQHEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4G8</accession>
    <name>S0E4G8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to DNA-damage repair protein DRT111</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_07362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430652.1">
        <property type="nucleotide sequence ID" value="XM_023577605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4G8"/>
    <dbReference type="STRING" id="1279085.S0E4G8"/>
    <dbReference type="GeneID" id="35400839"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07362"/>
    <dbReference type="HOGENOM" id="CLU_025002_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000495">
        <property type="entry name" value="Putative G-patch DNA repair protein (Drt111)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="313"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="388"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT68572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="480" mass="52901" checksum="C343252C93B645F7" modified="2013-09-18" version="1">MAAPPPPQGGLSLYENLLDPNDTPSTSATISSAPVLYSQTEDTSAEISVKKPIDPALRFQPIRRPQVKQAKPKPAFPKPAVSKQAVNSAPPAPVQPKTTLADWAATEEDEWMYGMGEKRQRGGRKKKKKRQQEEFETNWDDIYDPTRPTNVEEYLHSDEKVQEVRDWKALLYRHRHRRDESDLSDEDEDEQTRHVPSNQFAPPSSYAFVPPPLQSPPGPPPGDVSGDDAFARRVAISQEDAPLPPAAQASPSQPSNSATISRAPVRYSKPHDDEDAAGDNVEDDAYSPPPTLGSSLPDQPGDDSQARSSRPGQSGFAHRLMSKYGWTKGSGLGADESGIVNPLRVQVEKRRKKADADGGGWAEPGGKGKIIGGKRKEENAGKFGTMSDVIVLRNMLENMPNLEEEIAGGLGQEIGEECGEKYGRVERLYIDQESRKVFIKFTNQVSALRAVNELDGRVFNGNTIVPEFFDTEKFEQGKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4Q3</accession>
    <name>S0E4Q3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431944.1">
        <property type="nucleotide sequence ID" value="XM_023579035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4Q3"/>
    <dbReference type="STRING" id="1279085.S0E4Q3"/>
    <dbReference type="GeneID" id="35399263"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05784"/>
    <dbReference type="HOGENOM" id="CLU_009665_6_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47296" checksum="BA8C577A72ABA4F5" modified="2013-09-18" version="1">MTVKNTTNGNGNINIRAAIIGGGPGGLGAAIALAKLSFVDWALYEKKPEISETGGGISLQLHTWRMLEWNGASKNIKPSDLFRSPDGISGQQRNGRTGELIEQSYHPEDTPIHQRSGRQRRAKLQAALLKEVDESKIKLSKKLVGIEKLQSGRVIIQFEDGFTDEVDLLIAADGIRSVVRSFTFPSHRIKYNGQSAYRTIISKSEVNALGTIPQASTFWQNLGGRYVFTSPLGDDDFEVTARISRPSEGQDHVSWGRPFDFSTLVHEYDGFCEPVRQVVRLAAKGETQEFALFSGPRLDRVVALDSIALIGDASHPLSGAFGAGAGFALEDVYTLSKTLEWAWTRGGGIKAALELYDRIRSPHYHDLYNVLDWYAGIGKEIAAEGLSVDEEIEAKVRRTKGKKSNWMYYYDIQAVVDNVLDSLDSKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4S9</accession>
    <name>S0E4S9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable AMI1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431841.1">
        <property type="nucleotide sequence ID" value="XM_023578909.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E4S9"/>
    <dbReference type="GeneID" id="35399150"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05671"/>
    <dbReference type="HOGENOM" id="CLU_001023_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1586"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1290"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1422"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1725"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1855"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1440"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1473"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1504"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1518"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1542"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1740"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1761"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1855"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1874"/>
            <end position="1886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1886" mass="205985" checksum="9629436C553E7AB7" modified="2013-09-18" version="1">MASSLASDKPSLPAPGAAQYDPFITTTPPAPAPVPAQHRYSNYDHDFFVTGPASPESAKRALAAHLQETERRLEEAGKLGNALVLQRKQLTEQLKEIEKVNNEEELSQELRERMVGIEKEFNTLTRESARNLLPKQRVPSNEVNPNSPFAPENKGGRRSVSPSKFESQATGSPTKLTVPNRKIRNQPSNRVHDIEFAAEISTSLIAQVRNLQGVLAERDEENKDLKAEKARLELEAEGFQQRFKSLDESENRYKEENWNLETKLQELTAQHKEALDREKKLTQSLNVIKTEKVTIQRELDEVKVHHARLIDQHAAAVKQHDIELGTVKRNIAMAEGERAAMQRRIDDLTGQNQELARAFASQRRTVTELEPSIRASDDDLESSADHLTPEHSPPVSPIKGTPRHAMLETETMKSSLSHAQRTIQSQRGLLHREKTEKLELRRIIQDLRDDLEKARSDAGEHKPHRKSRVKESKEFKKPPRLLGSFRSSRQEVITDDGEWEDQHDVSPRASVSPMISRSSLSNSTQTILPSIETSHPTDTEQFETANEGGESAFETANERGTETEDFQTGAEEMSGSDDTETEGTTRGFGSMKNAPRLPAGFTRHASSNSLHSTASTSGDEDDYSYTKTPTGTIGSQRSSRFRMSRSIFNRSRQVSEEPNFQSSPVSFASSREGTPQAGGQSLFAELQDFGGSDDDSAGPGTPSRMRARSMTPGSIRRGSSPRPAVPPMPKVIMVDSGMMTEPVKIVPRLSGLGTSQMSTTGAMTDDGDEHFAESPVSVVAAIRRASMHSSIGPSGDRDRRIPSWAYDSLADSRPISMAYSDAGAQHDPDMEKNLALFPAPPSMLPILPPNLTMSSIASEEVEPVLEPEVVPIPPALTFTALSNQSVEPVSEPGSPVPDLTMTSIISQDLEPRAEPVVLPPALTLSGIMAHSLEPKAEPEVPPPDLSMTTIVTEQVEPIAEHEIPAPALSLSSISTEIVDPIAEPPVEPVMFMPPPPALSMSSIIGEHVEPVAPKNPELSISNIRGENIEPISEPVVPAPELLMSTIRSEHVAPVAQPETEVVIPAVVAPSLPPAPALSFSAIQGENVEPVASKAPELAMSNIVGEVVEPIAEPVQVPVIPELTISTIHGEQVEPVIESAPELTISAIQGEYIEPTDLPAPDLALSSIAIQSVEPISEPKKLAPKPSLNLSSIYAEGCEPREELPPTPTTLVFSGLSTQNVEPVSEPAPSLALSGIASENVEPVLEPLPLPPTLVMSDIATEGVEPVSPVHKTPTLPAFGFSNIESIETFPVSPRTPKRDGFILPRDMKSPFIKQDVPRTPENQRGIDQGSSPLMVEDENGQSPSDTPEPATPDSERPFDKPVVIMNDQGAQTSLTADVIDAMFKARAQSAFSHQKSLSMASIGTPGTTGTSGTVRIRRSQEMFETPSQHERDTDDVFNTSPIRRPGSSRSGRASVQDAPPLPANHRQVIEAARSNSSHGPQNNMGPPLWPASALKQRPTTPGNRAASPASTARATPTQRTVRNPVSYSELGRQSPSKHTAASRKSSVSSFASELDTRFNMRPGEMGMDPSGFGPNTDPRMIQAITQTMIGEYLWKYTRKTGRGEMSENRHRRYFWVHPYTRTLYWSDRDPSTAGRTELKAKSVPIEAVRVVTDDNPSPPGLHRKSLVIISPGRTIKFTCATGQRHETWFNSLSYLLLRTNNEQANVEDMAENFTREDVDEFNPQFGQRAANGTRPGAPPSLSSYNSRTTRNESPAVGMSMNIPTLTPKAQPQRPTGTLSKLSGYWKGSQLSGTLTSRRGRGSAHNVNIYEASEAHDSAEDVREIIERQDREADRLENVRACCDGKHDVGTLHHFSKRGRHGNSTHTHSHPGLTHSHTTMSSLRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E541</accession>
    <name>S0E541_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430902.1">
        <property type="nucleotide sequence ID" value="XM_023577914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E541"/>
    <dbReference type="STRING" id="1279085.S0E541"/>
    <dbReference type="GeneID" id="35401116"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07639"/>
    <dbReference type="HOGENOM" id="CLU_069001_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT68822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="248" mass="27437" checksum="117DBEF843538E9A" modified="2013-09-18" version="1">MPRHKKSSSVSRSHRSTLSLSKTEITIHVYDLLPPGRLSSVLWTVGASLLHSGVVINGREYAYGGHDKRGLTGVYWTKPRTEPPGGTFRCEILHGFTLATEDEINATLQSASEEFLGTSYNLLTKNCNHFTSYLCRRLTGQSGPAWLNRAASIGVALPCVVPRDWIEPPEYDTSEGALLDDYDNSNDDNSHTLKKTTDPHLLMGDNDSNEDDEWDSAEERRRGGSGKGKQALRDSAGRRLPPAERAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5C4</accession>
    <name>S0E5C4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mfs transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431980.1">
        <property type="nucleotide sequence ID" value="XM_023579080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5C4"/>
    <dbReference type="GeneID" id="35399303"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05824"/>
    <dbReference type="HOGENOM" id="CLU_073624_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485601" description="Mfs transporter" evidence="2">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16800" checksum="81EE7BB482DF4BDF" modified="2013-09-18" version="1">MARISLFILLLGALISLAAASAPTFCKCTCFKNSTIIPLGPKGETSSSQLRRAVLDFSTPDLEPRSKSKSCSECTKAFCLKQGIDFCKDATEEDVTTMCFQRDSNKDKIIVWAFIIGTVGLLGWAAFKKVVALRQGPTFGRQGSNYAPMQGNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5V1</accession>
    <name>S0E5V1_GIBF5</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023578336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5V1"/>
    <dbReference type="STRING" id="1279085.S0E5V1"/>
    <dbReference type="GeneID" id="35401496"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08019"/>
    <dbReference type="HOGENOM" id="CLU_029473_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="355" mass="40945" checksum="D9477749D72EC752" modified="2013-09-18" version="1">MDPTERLPPEIWREIIWNLRKPYHQGIICGLRWKENAEPQRPCHCITALAAVIEPFLFKDLHLRIDKVLGFKCIIFLTQQRLSYIRSAAVKCGLASHICKRSKRCTQGPGDCAFRQHHLKDEIEFNDIVYKIFGILKDLPRREKPYMDMIFEMPRIGFGVTFTQKGCSLARSLDLIPLSVQTLLIDYQREMIVDQTFNPPSLIPIGSNREAFAEAMRPLAPRHGIREITLLASINIAMFQPTTENPCWPIPKSFTFAFYNVLQSYQWVVTGENPLSAEEEECERQETREWVGGLHYCPPGCEIENSFKSYMREGTMDRFLLAAAQAVCHMPKIRKLSVRHVFDPAGFKEDILRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E632</accession>
    <name>S0E632_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430093.1">
        <property type="nucleotide sequence ID" value="XM_023576944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E632"/>
    <dbReference type="GeneID" id="35400244"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06767"/>
    <dbReference type="HOGENOM" id="CLU_054623_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="360" mass="41497" checksum="341A20E08EE1CF80" modified="2013-09-18" version="1">MDPEELKVLTETLKEKAAAQHRLRVPFRDIQSERHRHVLDGAIKNALATELAQFTYAQIMDGLPTGDVCFERRFPHVFGEHPIDSCHDELCPGAFDKAQEYYQQWNSAILTFDPMTIEKYQHAEIGSRAFKTRLVELVAVALHEIAVLLFQLDFQLHRGGKADIDYVTNWRIPASVLEGLVDVPPRPTLFSHHAYLDADIYPNGVADIVGFWAEDRILGGVAIFDRRAETSSDTPMPNIYFHSCRHKQTYRVYQLRDDQQEALFAFLLAETDCPPPEPNPLPILSDAQNRVRVDSEYALTHHEIFRDIWERKPITIEQRRLIDRQAKSDLDYPEALEEVVRINEQLGFPIPKFRERSPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8I5</accession>
    <name>S0E8I5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable aflatoxin efflux pump AFLT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_08754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433275.1">
        <property type="nucleotide sequence ID" value="XM_023580509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8I5"/>
    <dbReference type="GeneID" id="35402230"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08754"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="69"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT71196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="570" mass="61605" checksum="9BD12F1C89CE4F88" modified="2013-09-18" version="1">MTTPTSKTERNEPHPISGDDEKTESRSNTPTLNEPNQDEKPKKSEDGDGELTTEEEETEWISGWKLASMMISLTLAAFLMLLDMSIISTAVPRITSDFHSLPDIGWYASAYNLASAALQPLTGKIYMYFNTRWTFLALFFVFEVGSLICGVAQSSAMLIIGRAVAGIGSSGIQNGALTMIAKAVPIHRRPSLVGIIMGFAQLGLISGPLIGGAFTQYTTWRWCFYINLPIGAICAVLILFVHMPDHRANRDESTMQILKTKLDFTGFVLFCPSIVMLLLALQWGGLEYPWDSATVIGLFCGGGVLFIIFIYWEHRVGSEAMIPLPIVRTREVWASCLSQSFLFSTVMVASYYFPVYFQSAKNASPFTSGVNLLPSILSVIFAAVASGALAQRVGYYLPFATASGVLSSIGFGLASSMGPYASTATWAGYQILLGLGRGLGLQMPIIAIQANTSADVTPIAMAILTFSQTFGSAIFITAANVIFTHELRNELVARLPDINADMVIDAGAGAVSEVVSGADLPQVLWSYSRGVRATFLLAVGTSCAMVLSSFGMGWKDIRKKPDHSPILDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E924</accession>
    <name>S0E924_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431048.1">
        <property type="nucleotide sequence ID" value="XM_023578089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E924"/>
    <dbReference type="GeneID" id="35401274"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07797"/>
    <dbReference type="HOGENOM" id="CLU_1034535_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="242" mass="27559" checksum="0F7B0C494754C755" modified="2013-09-18" version="1">MTPPLDSIEPIRVLIGFRVECHDSDPRYASKQQIHLETNGRSSLTTECNIPDNKHHFIEAAANHLSRKQVPSPFTSLFRSWESAIQQRDYLIKKGAYDVLIIAIWLKDRVVYDAENITVSLGYVDCPATPDEETRQLYFHNDEIFITDGISASENRIFATFGGKKSEDEPVLISELTIEKQMLLSELMSAEVELEDVIGKGEITKTLASELFHRTGVLAYGQYYLLVRAICGRPPRDRDNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9E7</accession>
    <name>S0E9E7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable ADP-ribosylation factor-like protein, member of the arf-sar family in the ras superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1279085.S0E9E7"/>
    <dbReference type="GeneID" id="35402121"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08645"/>
    <dbReference type="HOGENOM" id="CLU_040729_7_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001317">
        <property type="entry name" value="Putative ADP-ribosylation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="213" mass="24154" checksum="756785291BF388CD" modified="2013-09-18" version="1">MYHLAKGIYLYATSKEEYSVILLGLDNAGKTTFHEQVKSMFLPNRPDPKLKTVPTVGQNVSTIPLQDMYLKLWDVGGQHSLRKLWESYYASCHAIVFIIDSTDIGDGNIEHEENVGRLEECRLVLEDVLQHSETEGVPLLILANKQDREDCVETIRIKEGLVKKVMEGDKGSAVRDSRVLAMSALTGDGVREAIEWVRTRVQWNKESRPPVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9P0</accession>
    <name>S0E9P0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431278.1">
        <property type="nucleotide sequence ID" value="XM_023578474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9P0"/>
    <dbReference type="GeneID" id="35407761"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14309"/>
    <dbReference type="HOGENOM" id="CLU_727702_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495692" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43918" checksum="9C7A5B162F7844F8" modified="2013-09-18" version="1">MRLSSFLLAAGLSSSALAVDASLDPWEIDPSCNGFENDIKDALTQSIDLADAARTSLEFLLAKMPDRNSDPDGAVKWARISSAANSIFGLMPNYKGHDAETQKYIEDLRDIFAKTANTLPSSQNNPAKGFSPILSQKPNAKPLMVCGDDVFQWYDVDDEPEPGVGKVRDQPAVSRYIQNGGTIAGAFYYANRWDFRQTKVASVGHCIGNREAVISSSDDIVIICPKMTSDAGKARITPRQYKTSAALGDHIMTNWVSNPTQLYHELMHWFGGVDSNLKHIIKDQVAVSEKGYLRYKDKNNQVEYYTRPPSQQELNQKGQRKQGAYGLRWIMNLARTYKDKNGNTNPYSGPKLATKNADSLALFSFMMYLDQFDWSKNGDAQDFTRLKNKLGLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9T2</accession>
    <name>S0E9T2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432581.1">
        <property type="nucleotide sequence ID" value="XM_023579811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9T2"/>
    <dbReference type="STRING" id="1279085.S0E9T2"/>
    <dbReference type="GeneID" id="35399958"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06481"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT70502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="307" mass="34120" checksum="A39064D1BA38CFC5" modified="2013-09-18" version="1">MSQTIAFVTGTTGNQGGATARELLNAGVKVHALVRDPSSKSAIELQRLGARLFPGSFDDISSLKAAVKGATAVFLNVLPVLSDTNLEVVHAKNIIDAATESGTVTSLVYSSVTMTGKHEEFPNWGPDYPLAWYWLSKAQIESMVRESGIKYWTILRPAFLMNNYHQPTASYMFPELGQRRTFLSAYIPETAMTVVDPRDVGKFAAAAITEPLSYNKHEIDLGVESLTPAQIVQELSRVSGVEIGLEFYSEQEAKDAALRNPKIYAELWANEVGYQVDFEELQKYPIRQTIFSEYLEKHRDEVIQTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAG9</accession>
    <name>S0EAG9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433704.1">
        <property type="nucleotide sequence ID" value="XM_023581034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAG9"/>
    <dbReference type="STRING" id="1279085.S0EAG9"/>
    <dbReference type="GeneID" id="35401759"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08283"/>
    <dbReference type="HOGENOM" id="CLU_006632_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="671" mass="74441" checksum="C6B04B1B28ADAA2F" modified="2013-09-18" version="1">MFSHPLHGAGQSDLSRSGSGSGRPLMATSGASVGNANARARPCDTCRVRKTRCVKEEGQTRCVLCTFHNQPCTFLRGPTPRQRRQNREKEREKQNDARDGDENQGNSTTSPVAGLEMGASPSSRHGDAASTPASVESNQQFTQMQQVMPFEDNMPEPSRPSILSNTLGLDLKTHAEYIGPTDYRDPVLLDLHRPNLLNQEAPPLPTTSTFARRLDYQTVFLVHPDESTASEKMRIADLDAIEATVHPLGRTLVDLYFRIVHPSFPILHKDVFISKHRLSHRHFAPSLLAAVYLVALDWQLYDSQLAGREVESIPDPAALEELAERTINQDMRRPKLSTLEAGLLLLQRNRKIVESGSHTHPMSNRMFTAQIVAMAQDLGIHIDCSSWSIPAWEVGLRRRLAWALYMQDRWGACVHGRPFLIQDNDWDVRPCTAPDYPELGQMDPEANPDHTSPIIVGWDLFIRHIELTQILSDVIRTFYSAAATRVGGTLDQMGVVAAVELAKPLVFRLREWHANLPARLQLQNTQLRELCANGALHLAHAAVEIALHRALVRITTPDTPASLYEVLRSTARAKLQSAIELLGSLRPEHTAAFWGSAAAYQAAEIGSLAGLLWATADSFDEMAWCASRVDELRWALRVRGAAAPFAREALRLLERDIGGLGMVKTANDSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAU4</accession>
    <name>S0EAU4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_05464</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431648.1">
        <property type="nucleotide sequence ID" value="XM_023578678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAU4"/>
    <dbReference type="STRING" id="1279085.S0EAU4"/>
    <dbReference type="GeneID" id="35398943"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05464"/>
    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.230:FF:000001">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000009">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="15"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="130"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT69568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="425" mass="46478" checksum="E876F9105AF3BBD3" modified="2013-09-18" version="1">MSWLSIPAESDFSIANIPFGIISTSSNATPRPAIAIGDHVLDLDAFAKGDGFSGSSEIQKYVDVFSQQSLNAFAALGRPFHRVTRSYLQDVFAKDTKNPVLKDNQKLQDTALLKRSDVKNHLPLTIGDYTDFYAGKNHAFNVGCLFRGPDNALQPNYTHLPVAYHGRASSVVVSGTPIRRPWGQILRPGNKVPDLAPCERLDIELEMGMFICRENEMGSPVPIDEADEHIFGYVLMNDWSARDIQAWEYVPLGPFTAKNLGTSISAWVVLADALEGAKAAGIKNDNEILPYLKEKKENNVLDIDLEVEIITAAGNKNHLSKTTSRNLLWSWPQMIAHHTITGCNLRPGDLLGSGTISGTESGTEGSMLEQTKGGKVPIQLKDGEERKFIQNGDTLIIRGAYGSGDKKVGFGEVSGQILEPLPLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBG4</accession>
    <name>S0EBG4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433166.1">
        <property type="nucleotide sequence ID" value="XM_023580381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBG4"/>
    <dbReference type="STRING" id="1279085.S0EBG4"/>
    <dbReference type="GeneID" id="35402345"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08870"/>
    <dbReference type="HOGENOM" id="CLU_038278_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="3">
        <location>
            <begin position="44"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="419" mass="48131" checksum="E553431597FE64C9" modified="2013-09-18" version="1">MTTSNNGPSAATNGDAIPKIGPHPGTISSSNQYTSELKLRRMLKDHGCDPARQDNYRLQGVQLIENVREYLQLPVRTFDTACTYFHKFRLNFRDVEYNYQDAALASLFVACKVEDTIKKSKEILAAAYNVKNPEKSVTPDDKMFENPGKIIICLERLILETIGFDFRTRYPQKLLVKVVRDIFGKEDGKPFFETAYAMCIDIYKTFVPIKRTTFSMVMAVVELTALMTEQHVDRVQEYAKTKRQYHWGSVMETMLDILDLYVQHGKSTKVGAQFDQNKIIDIKIRLNNDLDKAFEPRYLYYCSRCEAEDPQPSTPASATSPATSTSWPGDGKRTVKGPEGTLRFVFEPEAALREREITEGFFKEEFEEYEVEVEEPVPPPPREDRGGYHGHRERGNHRRGGPYGGYRGDRHYRGRGRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBS0</accession>
    <name>S0EBS0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431943.1">
        <property type="nucleotide sequence ID" value="XM_023579034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBS0"/>
    <dbReference type="STRING" id="1279085.S0EBS0"/>
    <dbReference type="GeneID" id="35399262"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05783"/>
    <dbReference type="HOGENOM" id="CLU_028906_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="58934" checksum="94B63F218836B3F7" modified="2013-09-18" version="1">MSNSTAFSIAYTEAQRRFDHLAHTLNGETWEKLEKRLFIQRTCKEVVSFVEVVCDHTARLVPPVILGRHNVIYRMHCDGDAFDIAVRQPRPDLGQFWGEKALHEATTISYLAQKSDVQVPYLFFHAPSSYIGPAMILLFVKSERSMSDALSSPGRDLEEVPVLDPEIPEEDLRILYGKMAGLLIKLFKPTRHRIGSLLEVNDKFSVAGRPITQNMYDMVFKASIPESVLPSSNQVYRSADGWYAASAAMHMAQLLFQVHDIVDSEDECRNKYVARYLFHSLAKNGHLSSFGFLEDTWSAQSQSLELSCSMPYGFDSFRLWCDELRPHNVLLNKHDNIAAALDWEFAYFAPTQFSLDPPWWLLLQPPELWMSGIDDWSQVYEARLETWLLSMEDQERGEEINFPAHLSAYMRESWLSGRFWLTYATRKSWAFDTIFWKYLDERFFGSRDGDTQESQFWRARVHLLGEEAQRVMAMVVERKMNDAEERVLADWDPDTANQLLQEALGHYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDD6</accession>
    <name>S0EDD6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to component of actin cortical patches LAS17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432482.1">
        <property type="nucleotide sequence ID" value="XM_023579690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDD6"/>
    <dbReference type="STRING" id="1279085.S0EDD6"/>
    <dbReference type="GeneID" id="35399849"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06372"/>
    <dbReference type="HOGENOM" id="CLU_023467_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="256"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="550" mass="63701" checksum="F41C069A439B2090" modified="2013-09-18" version="1">MAERWDRDRFERMRGEQNRDRFDDDRSYTRSTRGRDHSDERYDRRPGRGYYEEEDIRDRRYYGDDSRYQPQRERERDMPPPWARRADVLERERERDLPRRESPPRRPGFLRRQSSLDTFDRRPRFFQDREEYPPPARREDIRPRDHRDPRDDYRAPPYTPIPLPKSRGLPPPRRYGDEFYDDIKIAEPDYYGDDDFRSMPERVREREYTRSRNRRGRSRESRSTRTRSVRSSSYSSSSSRSSSSSGGTTVKSEYPKKGKTRIPAKLVSKRALIDLGYPFFEEGTTIIVQKALGQDNIDELLKVSEDYKKVEAEIAASREPKAPTAALPAPPPKEKVREPTPEPPPAKTPPPPAPPVQAPPAQAPPAAVPVATPGPPPPVQMMPPPQQTPMPPPPVQMMPPPMAQPGPPPGFYQPGPPPPPQGPFEYAEETVIRDVSPSRFTTTTTSSSWDSYHHHHHPAEELVVRTRSRSRSGREIRKEIKALERELAHRPRGRSTSGEIVRAERLPDGQLVIREERLEKVVEHRKPPRIEKDKKGPPPKLMRAMFATLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFF0</accession>
    <name>S0EFF0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to aminoglycoside N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434645.1">
        <property type="nucleotide sequence ID" value="XM_023582052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFF0"/>
    <dbReference type="GeneID" id="35405901"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12445"/>
    <dbReference type="HOGENOM" id="CLU_060091_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="AMINOGLYCOSIDE N3-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104:SF0">
        <property type="entry name" value="SPBETA PROPHAGE-DERIVED AMINOGLYCOSIDE N(3')-ACETYLTRANSFERASE-LIKE PROTEIN YOKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="TTHA0583/YokD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="272" mass="29672" checksum="D87D2D20CC11EF63" modified="2013-09-18" version="1">MTPPTLTGPLCTRPSLTQDLQNLGLKPQDTVLVHSSLKSIGWINGGAEALAQALLDILTLEGTLVVPTHTSSNSDPSKWVNPPVPEEWWQTIRDTRPAFNPKTTRSENMGVLAETVRTWPGAVRSMHPQTSFAAIGAKAKFITDGHDLDSMLGEKSPLARLEELNAKVLLIGVGFDNCTCFHLAEYRVNSPKADTSFAVSVNGAREWATVTDVSVNEEDFLEVGKDFVEQNSVAKGQIGAANCHLFSLPQAVKFAQQWFLSHRTANPQKTCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFM6</accession>
    <name>S0EFM6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to CPS1-Gly-X carboxypeptidase YSCS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_09372</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435884.1">
        <property type="nucleotide sequence ID" value="XM_023568733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFM6"/>
    <dbReference type="STRING" id="1279085.S0EFM6"/>
    <dbReference type="GeneID" id="35402841"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09372"/>
    <dbReference type="HOGENOM" id="CLU_021802_11_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="270"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT73806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="565" mass="62418" checksum="E4AE7FC61C83DDDE" modified="2013-09-18" version="1">MRFTDIVSTAFAAGAVAFSHDAQHRLNDKINVAGTAETNPKCHLPAPLNPSDDGLESSHDLFSSKKALQLMVKKHQSLVRIPSICYDDMGDLDTDDRWKPFYDIPKMLKKAYPTVHKHITPEKVNKFGLVYTLQGSDPSLQPILLAGHQDVVPVADGTLHEWVHPPFDAFYNETDGYLWGRGASDDKSAITAEMSALEALLSQKNYKPRRTVILAFGFDEECSGHRGAGYISKHLEKRYGEHGIAAILDEGGAGLQKMGDVLYALPAVYEKGYLDVWFNVSVVGGHSSVPTPHTAIGIMAEIVTTLEHNPFKPEIAKNGAIHQCLACFAEHSPHVFPDLTKLVNGGDLQGVAKFLTKLSRDMQYMVQTSQAIDVISGGQKINALPEFVTLGVNHRYAPQDSIGSIQHRIVGLVKEIAESHNLRVEAFEDDGDYDEYLAANNLSRQCNKDEELWGQKYKGTLTIAAKKKSYITPQSPTAGPIWDIFAGTVRHSFAQEAKTVVAAPGAMTGNTDTRHYLSKSLKWSPGSLKSFSNIHGVNERLLMSEQMNMAKFYYDFIRNFDKANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFY2</accession>
    <name>S0EFY2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434835.1">
        <property type="nucleotide sequence ID" value="XM_023582280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFY2"/>
    <dbReference type="GeneID" id="35406105"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12649"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="451" mass="48828" checksum="3CA6CE39D4B05734" modified="2013-09-18" version="1">MSSDNSTSTKEKAPEKGLLRYWKPSTTNQPPPDGGLTAWLQVLGSFLINLNNFGLANSFGVFQTYYETTLLRQHSSSAISWIGTLQVSLILIIGVISGPLFDQGYFYPILVVSSLMLTFALMMLSLSTQYYQVMLTWGVLGGICTGLLYIPSVAMIPLYFTTRRGLALGCATAGGSFGGIIYPIVVRRLLDSGGFGWACRAIGFITLFTLTIAVILIKPSTQAVKKPTRKLFDKSIIKDKAFIFFTLTSFFIWLGFLVPYILTPSFGLLGLDHPVSEDLSYYMLSVLNAAQALGRILPAAIVDKKILGAESILMFNVVVSGILALCWIAVHNLGGFTVFLILYGFFSGAVTTLPAFIIPYLCPSLAVIGTRMGIVYGAAGFGALIGPPIALAADEAHGGQHNRAFLGAQIWNGVTILFASCLCAYPLWEARKRRHMKEMADAKAKQGSNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EG54</accession>
    <name>S0EG54_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435842.1">
        <property type="nucleotide sequence ID" value="XM_023568686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EG54"/>
    <dbReference type="STRING" id="1279085.S0EG54"/>
    <dbReference type="GeneID" id="35402883"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09415"/>
    <dbReference type="HOGENOM" id="CLU_771794_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32885" checksum="AA8F3F471410DF24" modified="2013-09-18" version="1">MAPESSTQTDPAPAASPAVPPTAQHAPQTYAQQQQQQQQPGFQQDPRSYGPPYAPYPQQPAQQQWTPPRVAESKAWMITKLTLHGIDIVCCIVGLGLTGALRSTETLGLVALGACPLFVVAMIWDIAELATRFGRKWKAGIHPGAHVAISLFIWLGAAIVGGLESTFSAYYNEFDYLDEDCEYNSTQGRYICTSSDKVGSKRTLFIALSVFTCLVWLWHFILFVGACIDTQKRNAAMRRPVTMVFGGPAYWGPGAQGFQQVPQYYGPPQGQGIPMQNWAPPQMGNGKEPMAATQPAAERYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGR0</accession>
    <name>S0EGR0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to STB5-SIN3 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_09190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436052.1">
        <property type="nucleotide sequence ID" value="XM_023568936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGR0"/>
    <dbReference type="STRING" id="1279085.S0EGR0"/>
    <dbReference type="GeneID" id="35402659"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09190"/>
    <dbReference type="HOGENOM" id="CLU_012331_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="664"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="783" mass="87343" checksum="61820CC5E6BB3F27" modified="2013-09-18" version="1">MTTMDDNGTTNEDRFPVRLDGLGSVGRQSDNAAGRKGRVALACKRCKRRKQRCDGSHPTCKSCERVGTPCIYERTIRPQYPGGKTLYINALEERIAFLEARLPDHAQDHFETLAPSSVVDGQDNDVINVQAYPESSSSHRGSVSEDLDGYERNSIIDGVAYLSLCASGTAEATPDPSYLGSSSGAAIARMIQRSIFHNSRNGITRPSNFPRQANPSVDPYLESLAPTLHLHLDEPSHGFPFPDEARHLFDVFFDRMHTRWPILDRKKYTELFEVQYQQGALSITQRSIMHLIYAIAARFEQLTRKPSQVDPEKHLLAAIEPMDYILEQHNLATVQFLLLLAVHGQRSPYGAGAWSQVRYAVSLCIELGLHRERQGPPPSAAIARDLEIRRRAFWSCYCLDRGTSVVLGRAFAISDRDINVSMPNPGREYWDLTHASSASDDHAVEWCNIEPFIHIIKLEKIQSRIHRTVFRVDKDIFSGPVEERVRLDQKMASIRADLDRWIQTTPQSPKDNGRITWLYDPESTNQDAGDFYSLQYHKAVLALFTVLLPSLATTDPRFITTARSAACVCIAYKRLNQQRTLTYTMISLHSCFVAGLTLMYCIWKDKSLFSYHVVEATQACSQSLTVFGEKWAGAVKYRDIFDALSGSLLKTLMSPGGLSGDTGMGAHQTPPLQTKFDRPSFSASPGLSTHQPSSISNNSNEAGDITMRDLVSDAVKEAFMEVDEEAPGGWHGWQMWNEMLGEDPTASDLSTCNIFSGAAKGCKDVWNLSQGDLDLSKGWDLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGS4</accession>
    <name>S0EGS4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436067.1">
        <property type="nucleotide sequence ID" value="XM_023568953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGS4"/>
    <dbReference type="STRING" id="1279085.S0EGS4"/>
    <dbReference type="GeneID" id="35402644"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09175"/>
    <dbReference type="HOGENOM" id="CLU_012358_11_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF37">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485915" evidence="5">
        <location>
            <begin position="23"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="6">
        <location>
            <begin position="81"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="510" mass="56199" checksum="51195BD69BEA4D37" modified="2013-09-18" version="1">MKFEPAILIPALLVCNVAGVTASSKLFSGATIIVWDESEPEPRVLRDGYLLVEDDRIAKVTTSKPSRLPRNTEVIDTTGQIISPGFIDTHRHGWQTAFKTLGSNTTLAQYFGRYGEFAAAPHFNAEDVYWGQLAGLLEALNAGVTTSLDHAHHTWSNETAYAGLNASVESGARVFWAYTFHDVPTLNYTVNDQIPNFIEIAESGLLQHSNVQLGIAYDSFGPNPPDVANEVANLAREFNVSVVTTHSLAGPFGVSNLPEDVHSFDLLNTSIPVVFSHGSFLTATGANLLRQTNQYLSITPESEMHYGHTHPHSYYIQDQAALGVDTHFTYSTDILTQARIWLQSVRYFFFDKVLSGWEVPKNNPMSVVQAFSLATRAGGLALRHPELGVIREGAKADLIVWNAAESPSLLGWTDPIAAIMLHASVGDILHVMVNGDFVKRDGKLAIANYPTIRQRFLNSARRIKSIYRDFYYPTLDGEFNGGGFYYGEARVADTERGESNGYGELHLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH77</accession>
    <name>S0EH77_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable class E vacuolar-protein sorting and endocytosis factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436202.1">
        <property type="nucleotide sequence ID" value="XM_023568525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH77"/>
    <dbReference type="STRING" id="1279085.S0EH77"/>
    <dbReference type="GeneID" id="35403026"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09558"/>
    <dbReference type="HOGENOM" id="CLU_069208_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="228" mass="25589" checksum="99154C1CE57B44E0" modified="2013-09-18" version="1">MNILEWAFGKRMTPAERLRKNQRMLDKAIRELDQMRVKLEKQEKTLIQQIKTSAKNGQMGACKIQAKDLVRTRRYVEKFYSMRSQLQKISLRLQTYRTNEQMMQAMKGATMALGSMNKSMNLPQLQRIAMEFERENDIMDQRQEMMDDAIDDAMDVGIEEEGDEVVEQVLEEIGVDFNQALGETPTALGTAAVPEGKIAQAVGGGGGGGGGGDPVDDDLQARLDSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHC2</accession>
    <name>S0EHC2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to HOL1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_08117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433857.1">
        <property type="nucleotide sequence ID" value="XM_023581218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHC2"/>
    <dbReference type="STRING" id="1279085.S0EHC2"/>
    <dbReference type="GeneID" id="35401594"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08117"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_8_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF187">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="73"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT71778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="512" mass="56811" checksum="68974DDEF857FDEC" modified="2013-09-18" version="1">MDDLKPKQSMDEKVGDTALSSDLKDSEGYIAQVDTAHHGNLKLAKDGHTVLIPQPSDDTRDPLNWSPVKKHVILFIISFAAFLPDYGSAVGAVTLIPQAAQWNMSQDTVNHSQVGNVFMLGAGGIFVVALSAWAGRLPVLFYFLVIAAATAAWCAAATTFESFMAARILNGFFSTVSQGGGLMFIFDMFFFHERARKINIWAAFIILSPYMGPLLTAFIITTEPWPIAFWVYFTETSLALILTILFVEETYYDRRITAANQPPRGSRIGNLLGYAQYRSRHLRNSFGQACMRPIRVILKPTVFLSCLYYLLTFAWVVGINTTLSIFLTPLYNFGPKQIGFFYFTPVVAAILGEVVGHWLHDGIATQFIKTHNGHFEPEIRLRAIWFSTPFMLAGLVGLGFALQEGYHYMITALFWGLYVFGIMVTTVALNAYNLDSYPEASGEVSAWINFARTTGGFIISYFQVKWANSVGAKVSFGTQAGICAFAFLIVLVLQVFGKRMRAKSGKLCFPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHN0</accession>
    <name>S0EHN0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to nitrate assimilation regulatory protein nirA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_08176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433967.1">
        <property type="nucleotide sequence ID" value="XM_023581154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHN0"/>
    <dbReference type="STRING" id="1279085.S0EHN0"/>
    <dbReference type="GeneID" id="35401652"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08176"/>
    <dbReference type="HOGENOM" id="CLU_011581_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="51"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT71888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="595" mass="67088" checksum="4620A0F5AA7A7C93" modified="2013-09-18" version="1">MEVQTSPASTSQSHYGSVPSQASPMDMPASVTGGTQRVFELENRDTIRQYLDTYFDKSDIADCVFLHRATTIAEWSQGKLEKTLLKAICASALRFAPTYHSETSPAHNWIKQVQHELVNHMGDISVPKLQALMLVIKFLFSMRFTGDVWVLLSIASRVAFTKRLNYERPAIDPVKQECLRRLMWSIYVVDKVFSGGIEDLTVCPTQRMHIRLPSSHHNFQLGSRSKAPFLRSKNENDTDLNVLAYLMRLYDIRDRVLRYTRQVILGGASPYLSRGQLRSLDLELTSFEESLPDELQLTDNRLMIMCHSEEARTYTTLHTFLFSSRCDLHRFLIPGIREAVSPEAFGQTPREYIDYCQQQCLQTALRYIDMWSKVRQMETSSRVGTPTFAVVTYQFVKMVDHLAALLPLHGESSLPVIKQKFMDILLIVSGSRAEVGWIGSCVTDIENLIPRLGTRHISPGSPSASPGTIRLQEKLHRRSKHAFAPDDEEEEDPAIRPPESNTGEEIPETSLESAAFENPEGQDIWSFPVQGDEQGLTGSTGDGSLGSFSSMGYPLINYDSINSTDMVFGDQELGFPLDPFDLQMNAYTDANAPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHQ3</accession>
    <name>S0EHQ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to sensory transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436397.1">
        <property type="nucleotide sequence ID" value="XM_023569142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHQ3"/>
    <dbReference type="STRING" id="1279085.S0EHQ3"/>
    <dbReference type="GeneID" id="35403832"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10367"/>
    <dbReference type="HOGENOM" id="CLU_000445_82_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="755"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1076"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT74319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1209" mass="133960" checksum="02396C2FD9A86F5F" modified="2013-09-18" version="1">MDSEIAHDLDKLNIRDILNADSRPTFIIDLDPDDETPLRSKAIQPVFCNSALATHERLLDAVRGEQSESEYGDFKTWATGVTKQDDSKDVFPLFFLYKGLLWTGSTVGKRWRLISGNRLWQHPDTPASLSSSALSRASTPSLKEQDTPKGDFSKTPKQDEAKDETAEDMTHEMTPTEATLIASTPRKFPFRSWWRASTSKGSSDRNTGSTSSGSIILGKPEKAVADWTATNPKGLLSPYIRLLRAIDWSSTPLGPMSSWSPELRQVANLVINNPHPANIFWGNDMTMLYNEAYAVAFAGNKHPSMLGTGASGPWSEAWDVLGPALQEVVRTGVSFRSDNNDLALFRRGFLEETHICWSLTPLYGGTERIVGFYNAPFETTDLVLSQRRMGTINKVSESLRKATSIKSFWKSVLDGLEDNHRDVPFALLYSVGEAEEADHQSSSSGSTISSKSCYLEGTIGIPLGHDAAPEQIDLKRSYQGFVPSFREAMRTREPTLVRIRDGTLPEDLLQGIQWRGFGEAGTEAIIFPVRPTNGETVLAFLVLGVNPRRPYDEGYISFATLLNNQLATSLASTILFEDETRRGRDAAEAAALEKEELTQQLNLQASRLRRMTELSPLGMFLTSPEGILREANDRFYEMTGHSRDTPGDVSWANLMKNSGSVMEQGWHRLTQDMLPWSGEVKLRESFENPVNIHGEPIDFWVLVTAHPEITPSGTLRSIMGSITDISHLKWAQGLQNRRLQEAEETRRQQNEFIDITSHEMRNPLSAILQCADDITSAMQACRTNGITASQDVIESCLDASQTIALCVQHQRSIVDDILTVSKLDSNLLLITPVVCQPQTIVERVVKMFESEMLAKDITLAIDISTEFEKLAVDWVAMDPSRVLQILINLMTNAIKFTASSATRVIKVAVGVSKDPPEIDNIPGFAFAPTRGEIGSVVGSDEWGSGEGLYVRYRVQDTGCGLTDDEKKRLFQRFKQASPRTHYKYGGSGLGLFISKRLAELHGGRIGVASTAGKGSDFGFYIQARRCSPPSEQTSPQPILSEVPSTKKTLHLLSPNPSARTRRESILAAVFTPSALTVHVVEDNLINQKVLVNQLRKAGCTVSATNDGLEALEFLKKTHFLKTGGSDLSVVLMDLEMPNMDGYQCVREIRRLEREGLIAEHVPVIAVTANVRDEQIRMALDSGMDDLVSKPFRIPEVMSKIEGLLKKCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHY9</accession>
    <name>S0EHY9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436684.1">
        <property type="nucleotide sequence ID" value="XM_023569472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHY9"/>
    <dbReference type="GeneID" id="35404127"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10663"/>
    <dbReference type="HOGENOM" id="CLU_2573983_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012926546" description="Hydrophobin" evidence="1">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8550" checksum="BE00342F42C34FAF" modified="2013-09-18" version="1">MKASIILALPAIAAAAATPQVKERQVPTVFDPECLLQITGISVCLPNLDVNSVVGIDEVALCPVRLLARILRCINVDGVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI37</accession>
    <name>S0EI37_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to sulphate transporter proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435580.1">
        <property type="nucleotide sequence ID" value="XM_023568372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI37"/>
    <dbReference type="STRING" id="1279085.S0EI37"/>
    <dbReference type="GeneID" id="35403164"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09696"/>
    <dbReference type="HOGENOM" id="CLU_003182_10_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000036">
        <property type="entry name" value="Putative sulfate transporter YPR003C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="653"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="801" mass="87416" checksum="FB296485E33117E2" modified="2013-09-18" version="1">MAKRPSHSRTNSGTDHRPTQPSALRQALSAHDRNESESPAAEGFTTPTSIPVASPPDSPGHPPGATINEIFANETTPLIDGNNQRSNTRRGSVHPAHPGVCSHGTFSPRPMSPTLTMRSTDEDGSETAGSGTHIPVLDNAITSIVGHEDWKKWLKKRMRTKTMGHSSMLAEQAGFEDTAFMYLAYYVPCLNWMRQYKVSYLRGDLVAAITMASFYLPMALSLAANLAHVPPIHGLYAFVFNPFIYALLGSCPQMVVGPEAAGSLLVGTVVKQNVGSGEDEDNDLLHAQICGIVAGMAGAMVLIAGLARLGFMDSVLSRPFLRGFISAIGFVIAVDQLIPELGLAELADDAGVSHGSPVEKIRFMINNIHEAHGLTFAIAGISFLVIMICRELKNRLQPRYPGVAYVPDRFVVVVVSAILCWRLDWENQGVEILGTVKAANGQLLAFQWPFKLEHMPHIRSAMATSFLIALLGFFESSVAAKSLGSSETIQGIQLSANREMIALGIANMVGGCFMSLPAFGGYGRSKVNKSTGGKSPASSMFLSIISLLSIFFLLPYFYYLPKPVLSAMISVVAYSLIEEAPHDIGFFLKIRGWTELGLMAVIFFATMFYSLTLGMAFGVGLSMLMVIKHSTRPRIQILGRIPGTNRFENAEGDKASLEFVEGCLIVKIPEPLTFANTGELKSRLRRLELYGTSKAHPALPRLRSTDMNRNVIFDIHGVTSMDGSGTQVLTEIVRNYHDRGVRVYFSRCPARKDHPVWRLMSSSGIVEMAGERHFVNDVEEALRLTEYEESIAGESSRAQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI60</accession>
    <name>S0EI60_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to sexual differentiation process protein isp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_10764</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436779.1">
        <property type="nucleotide sequence ID" value="XM_023569584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI60"/>
    <dbReference type="GeneID" id="35404228"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10764"/>
    <dbReference type="HOGENOM" id="CLU_004965_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="689"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT74701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="751" mass="83964" checksum="58ED4D9CD6451140" modified="2013-09-18" version="1">MTASVEKGLADAEVAAPNEGLVRPETSSGESVEEVLSAAGVGFKDDDPTLPCLTLRMWTIGIAFCLVGSGVNTLYTLRFPSISLSQSAIQFLAYPVGKAWEYAIPDWGFTLFGKRHSLNPGPFNHKENMLIYILANLSFLTRLSADVLTEQRVFYGLKAGWGFEILATLTSILFGFALSGLTRSVVVEPKSLVWPGVLGNTALNAALHTPRQEVIAGKLSRYHFFILAFVASFCWYWFPDFIFPALGYFTWICWIAPKNPVVNQVFGMKSGLGLLPFTFDWSQIAYIGSPLVVPVWAILNVLASLVFWIYIISPALYYSNTWFSAHLPLQSNSIFDNTGEVFNVSKVVNKKDGFTFDHDLYARYSDIYLPVTYALNTFGLSFATISSLFVWLFLEKRRDLARTFRDACKSLTLKNTSTRDRLQPQYDAVPLWWYTTAALVALGIGIFTYEYYPVQLRWYGVIFGMVVSSVFFIPLAWVYATSNIKIQIDIFCRIIAGYVWEGKVLANIWFFNVGYISGIKGLAFSQDLKLGIYCGIPPRSLFLVQVVGLIVGTLGQVSVLNWALGNIPNVCNAKLAPNGFTCPFSRTHFNTSMVWGALGPRRFFEPGALYRPLLWFFLVGALLPVVVYLLRTKAFPHVNWLKKIHVPLFLGGLNYIPPASGVNYGSWALFGLLFGALIKKRKASWWHRFNFVLSSALDCSVAIAGIVIFFAIFYTGAADNFSWWGTNVHKDTCDWKSCPYKALAKGQTFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI90</accession>
    <name>S0EI90_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436587.1">
        <property type="nucleotide sequence ID" value="XM_023569362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI90"/>
    <dbReference type="STRING" id="1279085.S0EI90"/>
    <dbReference type="GeneID" id="35404028"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10564"/>
    <dbReference type="HOGENOM" id="CLU_488362_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="552" mass="60438" checksum="163C6FF5FFFF2969" modified="2013-09-18" version="1">MSFTNHPLLINIYDALRGKFDAGDKTLFQMQVPTQPLQKSEFHYDGSDSNFAQIIKPVPVTEAEFRLTDGMLELSNIVGGPNGSKLSEKYDQVLSGLISADRADEELQQAREDMRSCVSRNIDDTEDIYPLNLVPSDWAKSLSVPSQQDDTASIKSQLQDTIRQHRFLEARRDTLMTVGDFKSLQKAVNDARAAVYATEAEMAKGFTDTVAECIKLYFAQVCSMAQDSIAAVKGLNNANKMELGTLLQKYQGGPLSDEQWRFLVALQLKHVQNLNDLAEASKMLNRAQVEVSQVNGRDKGVELGVINDQIALLAVEIEKYQNMLRETGSQNFEKISDAFQGNASTPGWEILTIDSRTLTQTQSGLSCTSSANLAWSTNILSYGESGLTSFAAVDQGRTLSTENTDVRVMLSLTKVAIDRPWFNAQVLGKGTGPIASTAAKLSAGNAEDVRKLFASGSIIDTTEYQLPAWTTSFLVVQDVCITLTSHTTFQRSQVQEIDNCLSSGGSLLVFRACKSDTNGNQGAGYGIKSDDKMIQVRISAPQILGWSTQISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIN3</accession>
    <name>S0EIN3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436949.1">
        <property type="nucleotide sequence ID" value="XM_023569784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIN3"/>
    <dbReference type="STRING" id="1279085.S0EIN3"/>
    <dbReference type="GeneID" id="35404407"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10943"/>
    <dbReference type="HOGENOM" id="CLU_021768_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="324"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="540" mass="60861" checksum="91749D63CD0A2109" modified="2013-09-18" version="1">MNSTVDPKFQEAFSFIQSEYLPHPLGKFLRSFIANALNPASAATHVLSHCRQGQHSKAHLLALISDWTFIVESITKYGTTPPAPDSRTQAQIIRRDGNRCCITGKPGSLKDPLVVMPVILAPSRWLEAEPRVHEMLRAFFSPLTSIDPIDSHWLVCRSAAEAYRNGLVKLHRLHPSMTEYRVVWCLIGTVGPMIDVDGQYPLLGDHSRSGIRKVDARFIGTQGRLASSMRWLEVKKKIVDNETVVAQAGIQPLASRPSFVSAVFQMCRTIFWQAWLLAPPFIRLSTYKVLRKMVSHLYGSTSSLAVSRLPFGLYLKATNEGASNESNALGLVHKYTSAPVPLVLDLVADSRNTYLLTTGLRGEPLSRAMDMLSDRDCHDFIDQMQSYISQIRAIPSVDTRNYICNTLGEACRDPRIRDGNPIGPFEDEASFSQYLRHPDDPARRGHQIVFTHADLNLRNILVDKVTKPDGTRGWAISGIVDWENSGFYPEYWDCTKAQFEGFRWDERWTRALVEVFRLFGGYAKEIEVEKRSWSEGDGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJB4</accession>
    <name>S0EJB4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to glycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_12343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434546.1">
        <property type="nucleotide sequence ID" value="XM_023581938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJB4"/>
    <dbReference type="STRING" id="1279085.S0EJB4"/>
    <dbReference type="GeneID" id="35405799"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12343"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12163">
        <property type="entry name" value="2-Hacid_dh_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="128"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="231"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="365" mass="40765" checksum="5B0CF8C757511B24" modified="2013-09-18" version="1">MTLIRISNNKTLKGHKAIIFSTVELPEAQIDAIQKQFPDLTIKIFIQPWGAPLDPSFKEEEWQDTTVLLTATLLPKPEQATHLQYVQLTSAGANHLIKDPLFTDTKVPFSTANGVHGPQIAEWIITTYLSHRLHLKEYSKLQDEGKWKRLHQGAEDTEDTAGKRIGILGYGSIGRQTARLSKALGLDVHAYTLHPRNTPESRRDDSYTPPGLGDPEGEFPSKWFSGGSKEEIHEFLDSGLDILVISVPLTDKTKGLISKPEFEILGKKGTFLINIARGPIVDTDDLIEALNSETIKGAALDVTDPEPLPDQHPLWSAKNVTITPHISAASSFYYTRLLDIFRLNLERLSQGRTDFINKVNRKEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJD0</accession>
    <name>S0EJD0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to monophenol monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437179.1">
        <property type="nucleotide sequence ID" value="XM_023570055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJD0"/>
    <dbReference type="STRING" id="1279085.S0EJD0"/>
    <dbReference type="GeneID" id="35404649"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11185"/>
    <dbReference type="HOGENOM" id="CLU_360169_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496031" evidence="7">
        <location>
            <begin position="18"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="331"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="777" mass="86436" checksum="CC409B3F4B538FD7" modified="2013-09-18" version="1">MFFFLLTVLALVLPVPAISSSNSTCTSKNIQTRIEWANMASNDQQSYLKAVECLMQLPAQTGIKGTVTRFDDMNAMHQVQAKTIHLVAQFLPFHRLYIYVYEQLLRDECGYKGPTPWWDETRDAGNFIDSPLLDPNTGFGGNGTGPHHCVIDGPFANTTLHIGPGQSVSDHCLSRKVNEFNSTLGNETYVHECHSKTTYLDFWETTGYTTHGAGHSGVGGVMEDIDASPGDPLFYIHHAFIDRLWWKWQSEDPDSRLYQLGGSSTQGGTEELTLDYVMTTYEIRPNVTVKERDAPSSSLRLAEDGHTVLLPQPTDDPNDPLNWSSRKKHLILLVVAWAALTSDLTSAAGSAPVILQAAEWHKSPNSVNHNNSINVLMMAIGGLIWVTMTSIIGRAPTLFWSTFLGLIFSILSSVSTNFEMFMGVRAIQGLFLTSGQTIAIAFIKDIFFFHERARKIGLWALMYITFPYWGPLLANFVIGETHQWQDAFWLGVGVNGISLLLILAFMDETWYNRDLPSSVQPSRGQGFFSRLLRLTGLWQVKHHSGYFESAYDAYKRVLLILSKPVILLVIAPYFMCFAWAIGVNISTAILFGLPQAMGGYGYSFTQLGYLHFAPIVGVFLSEIFGHFFNDHLTRRYVQKHNGVFEPEARLMTIYISIVPMIAGLVLMGQALHKHLSVAAIVVGWGMHAFGIMLTSVAVASYLLDAYPSAPAEVCGLTNMFRALSGFSVGYYQHPWGAKVGYDVSFGTQACIVAASMILIAIVHRFGHQLRLKFGQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJI8</accession>
    <name>S0EJI8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Secreted protein CSS2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436893.1">
        <property type="nucleotide sequence ID" value="XM_023569720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJI8"/>
    <dbReference type="GeneID" id="35404349"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10885"/>
    <dbReference type="HOGENOM" id="CLU_099521_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046624">
        <property type="entry name" value="CSS2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20521">
        <property type="entry name" value="DUF6736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485982" description="Secreted protein CSS2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Secreted protein CSS2 C-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="207" mass="22636" checksum="2769009A241C0B92" modified="2013-09-18" version="1">MKLALMSFFVLMSLPLSIYSMPTTEVTEAINETEAVNINEAVKMPDSLALYHLEDFESENYALEKRRHVTVCERIITITSHCVIIGGAIKDGILQISAAIKHASNVKTCSTFTGHAGPNGNLFYRYRSTGGHCDTTAEQETIAGAIEHHIKNHGHKICGTQCLELTHGGTWHGYLLIGPASNFDHKAYCGPKVTFKHCDSGGKGDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJR2</accession>
    <name>S0EJR2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable RPL34B-ribosomal protein L34.e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436160.1">
        <property type="nucleotide sequence ID" value="XM_023568486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJR2"/>
    <dbReference type="STRING" id="1279085.S0EJR2"/>
    <dbReference type="GeneID" id="35403062"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09594"/>
    <dbReference type="HOGENOM" id="CLU_118652_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46595">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="116" mass="13291" checksum="6A68BD1DA349C557" modified="2013-09-18" version="1">MVNHRVTYRRRNGWNTSSNTTRTVRTPGGELRVLHIKKRGTVPKCGDCGSKLIGIPALRPREYSQISKPKKTVQRAYGGSRCGNCVRDRIVRAFLIEEQKIVKKVLKEQEQSQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJT2</accession>
    <name>S0EJT2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_10978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436983.1">
        <property type="nucleotide sequence ID" value="XM_023569823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJT2"/>
    <dbReference type="STRING" id="1279085.S0EJT2"/>
    <dbReference type="GeneID" id="35404442"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10978"/>
    <dbReference type="HOGENOM" id="CLU_002833_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485987" description="chitinase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="26"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT74905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="417" mass="45485" checksum="7B9D919A6588922F" modified="2013-09-18" version="1">MPSFKAISASLVGLLSLGSASVIPPVNSEGYLVASTYFAGFHSTRGFPVSAMPWDKYTDVKYAFAETTPDGSLNVSTSHPENIPCFVKDAKKHNVKPLISIGGWAGSRFLSSNIDGAKNRTNFVKNVIDFVEKYGFEGFDIDWEYPNRQGLGCNVINKDDTANLLEFFKEIRKDPKGKNYYITAAGSVFPWNDNTGVASKDVSGFADVLNYIMLMNYDYYGAWSAVAGPNAPLYRSCDPRNDQGSAEDSVTKWTAAGMPASQLVLGAPNYGHGFKVNSTSAYGKSKNHKLQLYPAQNSTDRFQGSSWDNDPLIDACGNPNPPGGTYPFWSLIKEAHFLDTKGNPASGIASAWDNCSQTPVLYDAKREIYVSYDNAASFYDKGKFVLKNKLAGFGTYEAGGDYNNILINSIRSAVGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKL4</accession>
    <name>S0EKL4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435016.1">
        <property type="nucleotide sequence ID" value="XM_023582489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKL4"/>
    <dbReference type="GeneID" id="35406292"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12836"/>
    <dbReference type="HOGENOM" id="CLU_1586518_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485382" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18385" checksum="1D354741D0702954" modified="2013-09-18" version="1">MKLLTLISALATASLVSADQRSQLEHPNWRANRLSARGNTCPRPMCQTPPSQGPNDAPACGDSYAACKFDQFPCDDHMTPKVTDTHHCYCIFADNRAMTAWCRERGFKSGNNPWIYHYAAQCYGATSDKVCNDFCQFQDLGNGRINKANPNGPCACDKPWPPADFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL06</accession>
    <name>S0EL06_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436655.1">
        <property type="nucleotide sequence ID" value="XM_023569439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL06"/>
    <dbReference type="GeneID" id="35404097"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10633"/>
    <dbReference type="HOGENOM" id="CLU_994134_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="58"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="275" mass="31169" checksum="9857AAAFB50D6CD0" modified="2013-09-18" version="1">MRHSKKMQVADGDDHYTPSKKSQTSRKGNGSGKQLQQLYRLYEDARDIYNQSALAKTIEDMLRTKNRPRITKIVSLGLGSLLDAKDQQRRIKQLVVLMAIASHLTLSTGDKRKLRIYAQDPTFTAADETFLQSLDISVLKTPSIANLGEAGQMMDEETLIYSPFLTLETYKLLLSSSQSSDGTVRAPILVSDDFNALRLKWDKRTSERKDVEGLIQGAREYRRRAVSGEGFWTQADRPFPMALYWRDVGAARNTIRSESQSSFSRFEHHAIPIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL33</accession>
    <name>S0EL33_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437779.1">
        <property type="nucleotide sequence ID" value="XM_023570705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL33"/>
    <dbReference type="GeneID" id="35405230"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11769"/>
    <dbReference type="HOGENOM" id="CLU_102253_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004486027" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19978" checksum="CEFC992DCA57C9E9" modified="2013-09-18" version="1">MLAQTIFSILAIATTGLAAPVEPRSDDYFTPAEIHTYNINNGAIYDTDEGRVTKAPTNGGNDITTLLTFKYPEAARGKKCQFAFYLAPGENVIGSKKLDLYSSLAPAPGPRAGWGPGNQRNVHLGRMDVKVGGFATWEATYGPYMTQKTDCKKPGTVEGLELVGVYDLDAIYWNPAKSGPRIVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL96</accession>
    <name>S0EL96_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437612.1">
        <property type="nucleotide sequence ID" value="XM_023570509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL96"/>
    <dbReference type="STRING" id="1279085.S0EL96"/>
    <dbReference type="GeneID" id="35405054"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11593"/>
    <dbReference type="HOGENOM" id="CLU_1049773_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="266" mass="30035" checksum="D9180BE1B6721B1B" modified="2013-09-18" version="1">MSTSYKHTLFLWIEGYFPKRITYYLLSKGICSSVEQLYDGKTNESNLKIVPITFTGDGFVSQDPEEPLPPGSKVPALRLDDTESGRSVLIHETCSIINYLEEVFTGNKYRQMWATSPINRAIAQDVISYIALATDAGRIWLINCAPYMAAFWKIPDSELSLSAGRRARREFEGHFKTLQDMAADNLTATGWLTPAADGGPGMADVMLAATVRHTELSWGEFILEHKGLGRLREWYERFKTLGFWYELEETGRFPDNAKRGEGSVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELK0</accession>
    <name>S0ELK0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_11720</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437732.1">
        <property type="nucleotide sequence ID" value="XM_023570651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELK0"/>
    <dbReference type="STRING" id="1279085.S0ELK0"/>
    <dbReference type="GeneID" id="35405181"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11720"/>
    <dbReference type="HOGENOM" id="CLU_011500_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008559">
        <property type="entry name" value="PRK11504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="17">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="18">
        <location>
            <begin position="101"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="16">
        <location>
            <begin position="230"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT75686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="682" mass="77109" checksum="B77030EE03256C5F" modified="2013-09-18" version="1">MSGSVPHPFDPLSGEEIRLATSIVRKEHGDAVHFHVITLQEPRKAEMVAWLANPSSGARPRRVAEVVIIDPRDGKGHVYDGLVDLKSQRITKWERAEGQQPILIVEEMLEVEQACRKDPQVIEQCRISGIDADEMHKVYADPWTISHDTRYGSSTRLFQGLMYFRPDIDNCQYQYPLDFHPIYDPRKKEVIAIDIPRVRRPLQRNKAVDYHHLYIQKEGGYRKDLKPIYISQPEGVSFNVNGRELEWQNWKFHIGFNYREGIVFNNITFNDKGNVRPIFYRMSLSEMVVPYGHPEPPHHRKHAFDLGEYGAGYLTNSLSLGCDCKGAIHYLDAELPTQTGQIRKIENAICIHEEDDGILFKHTDFRDNSTIVTRARKLIVQHVFTAANYEYAIQWVFHQDGTIQPDIKLTGILNTYVMNPGEDLQGYGTQVKKGVNAHNHQHLFLLRINPSIDGHENTVHMVDAVPSDAPVGSPDNLYGNAFYAKRTRLETTGQAITDYNGATSRSWDIVNENKLNSESGKPVSYKLVSRDVPNLMPKEGSLVWKRAFFARHAVHVTKYADDELWAAGNHVAQTSGEPSRGLGAWIGDGTKSVANTDIVLWHTFGITHFPAPEDFPVMPAEPITLLLRPRHFFTCNPVMDVPPSYSVTPSEVAAKKAGFDTTDKVSKLAAMNDSSCCKPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELM3</accession>
    <name>S0ELM3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436880.1">
        <property type="nucleotide sequence ID" value="XM_023569704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELM3"/>
    <dbReference type="GeneID" id="35404336"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10872"/>
    <dbReference type="HOGENOM" id="CLU_921492_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="302" mass="35131" checksum="790711266E2160C7" modified="2013-09-18" version="1">MGELPTSDPEPNVESLSDLSSFRLFSQLPAELQFMIWEAAFCATSRFINIRLYMALGYNGGSNLPRPNMCITGGSFILRGRETDKFRESHRLSLACWVARKVYLLRYPQSIILLNSIRRKDGYSRIRCNIAHDILCIEKINGIFHEHDDRRLFTTPLLTQMARQAFSSSRKVLSSFQHVAVRLRRGYPSRGQLATAFATARLHFTVQQATLFLFSFFESIRHLYFPVKSENPATDDTEFFRGLPAQGYTPAPVQSFLDFYDRVQRYSEQVNDSDCDVNHRKWRPRPLRDIQCYYGREWLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELR0</accession>
    <name>S0ELR0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable BAS1-transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435406.1">
        <property type="nucleotide sequence ID" value="XM_023568050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELR0"/>
    <dbReference type="STRING" id="1279085.S0ELR0"/>
    <dbReference type="GeneID" id="35403453"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09986"/>
    <dbReference type="HOGENOM" id="CLU_031723_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="71"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="124"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="450" mass="49493" checksum="3603E8EB68BDA4DD" modified="2013-09-18" version="1">MSGQETSPQSPPANTPKHRRPWTAAEDATLRTLVGHFGASRGSEGRWKDIASGLEGRTAKDCRKRWLHSLDPSLRKGRWTSQEDEILLSAYARLGPLWNEIALLIPGRKDDQCSKRYNDILNPSAKNRLSDWTAEEDNLLRQGVAALGHRWVAISSRIPGRPPLTCRNRWRTLSRLSHNRQSRSQGTTPSSSSQMSPFDNGISPAAHNPNLGIETNHGATTDLMHFPMDADMGHDQMGSSFLDSAFFDTFTGPSPSPLRESDPSDETETPNDVSAPGAASENTAPVPDLSSSIATQTQSDPKPWPQPPKPPQAQQHQNAPNASFMPSPSTWSSLGTMLPPGTSPTDQNMWLGMTGNPPTPKNWTAPGPADSSNSLPQSFTEQFQVPAVPGVPASTQQTIHHHHHHHVHHHFHHYHHYPGNGDQWRQLEQQSEAEAMQAHLQNENGPQNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMH3</accession>
    <name>S0EMH3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_09633</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435641.1">
        <property type="nucleotide sequence ID" value="XM_023568443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMH3"/>
    <dbReference type="STRING" id="1279085.S0EMH3"/>
    <dbReference type="GeneID" id="35403101"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09633"/>
    <dbReference type="HOGENOM" id="CLU_047148_1_2_1"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1300.10:FF:000002">
        <property type="entry name" value="Pantoate--beta-alanine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT73563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="375" mass="41221" checksum="A201873E88A74BA1" modified="2013-09-18" version="1">MLPLRFLRHRSPFATSVRTASSCSTSSRLETLAKSPIRVLRSVEAVRRWRNPHVVNHRSVGLVPTMGALHEGHLALIRAAAKENHHVVVSIYVNPAQFGIKEDLSSYPVTWDEDAKKLAALDRELADDGGNLGRISAVFAPTTPEMYPSGFPGQEINSKGSFVTITPVGEVLEGASRPTFFRGVATVCLKLFNIVQPERVYFGQKDVQQTVVIRRMVKDFILPMEVVIEPTQRELDGLALSSRNVYLGPRRRAVATVLPHALFTAAEVYNTKVSRKREEILGAAHNFINATASGQSTLPPTERVLFEVDYLSLADPETLVEIDEVDPSRGAVMSAAIKMLPVEQAQNGEDLGFSGGPAVRLIDNIILKPQEPRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMN2</accession>
    <name>S0EMN2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437230.1">
        <property type="nucleotide sequence ID" value="XM_023569465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMN2"/>
    <dbReference type="STRING" id="1279085.S0EMN2"/>
    <dbReference type="GeneID" id="35404120"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10656"/>
    <dbReference type="HOGENOM" id="CLU_020336_50_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="286" mass="30880" checksum="4B7124D3304468DF" modified="2013-09-18" version="1">MPFIKVQNKTLFYAQVDAETASKDDLVLVFIHGLGSSHSFYIPVMNQLATAGYSSIALDVYGSGLSVLSEAVEDPTFDTIASDVKALLEGLSIRLENAVAVGHSMGGIIVPKLALKCNLRGAYWPCAAKACDGRDLQYAHRDSQERQVNLKCSEYDLVLILGLEGMEPMAKTIPFAATGSKATLTQKAFIRALLLSQKPEGYIALCRAIAQADLPPYANIKCPVLVLSGEEDKTSPIPDAQKILKDWGCDDSSKSMHILPGVGHWHCIEAADEVGSKIQEFLPKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENF2</accession>
    <name>S0ENF2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to L-fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437575.1">
        <property type="nucleotide sequence ID" value="XM_023570466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENF2"/>
    <dbReference type="GeneID" id="35405016"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11554"/>
    <dbReference type="HOGENOM" id="CLU_028200_0_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="379" mass="42731" checksum="4F45AC1966C562C3" modified="2013-09-18" version="1">MRSRQPDLWAAEYITFAAATIFLILRIASRRITRIRFWWDDYFACASYATAVCWGIVLPIWIHHGFGLHAKDVEGMTFTEANYTTKKYLFIMEHFYAFTLFFAKISILSFYWRMFRVANIQIFVSVLLVCSILWILVRTFLTTFHCYPVRAFWDPTMEHYTCAIKSSDFFFGTVLAHVIIDVGILILPIVQIQKLQLPTLQKIAIIFMFMFGILVCVAGLVIVSVSASFDNKSVDMTWQLAPVIIWASVEVNLVTVSTCLPIIRPACLYLFTCTNPVSSIRSGSNNFGSNYGRSQTKHSIRLGTIGKDESSSTHELARSEPSGSESFNSEFEHEDQRHGNIATVTGPGSSANLAHPADVGGIMVKNETVVHVSRARSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP71</accession>
    <name>S0EP71_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_10776</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436791.1">
        <property type="nucleotide sequence ID" value="XM_023569598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP71"/>
    <dbReference type="STRING" id="1279085.S0EP71"/>
    <dbReference type="GeneID" id="35404240"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10776"/>
    <dbReference type="HOGENOM" id="CLU_005732_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004486121" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="399"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT74713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113450" checksum="2E6182A72D4984EA" modified="2013-09-18" version="1">MKLLSLSTVGLLALAGLSIGQETKDVPIQDNGLTNIVEWDDHSYLINGERIFVFSGEFHYWRLPVPELWRDLLEKIKAAGFTAFSIYNSWGYHEATPGVLDFENGAHDFVSIMTLAKELGLYLLIRPGPYVNAEANAGGFPLWVTTGEYGKLRNDDPRYTKAWSKYWTEISKIIEPHLITNGGNVAMFQIENELGGQWKNDDKRILNEPTANYMQLLKESARKAGIDVPVFHNAPNTRTFSWSNDFERNATGNVDVTGVDSYPSCWSCNLDECTGTNGEYVPYNIQDYVTYFNKQSPRQPHFLPEFQGGSYNPWGGPEGGCPGDIGPDFANIFYRDLLAQQATAISLYMMYGGTNWGWFACPVVATSYDYSSPISENRAIWDKYYETKSLTLFTRVAHDLTKTIRVTNSTSLSTNDAILISELRHEENDAAFYVARHDHSPSGTKETFRLHVKTSEGKLTIPQNDGAITINGHQSKVIPTDFHFGKKTLLYSTAEVLTYSIIDNKEVIVLWLPEGEQGEFTLKGHTELKHDKSLNGIKVKAGKKSVTVNYTQQKGLFTLNLKDGSTIVLADRKTAYKFWAPTLDNNPFAPVNKTVLVHGPYLVRHATIKNGQLNIQGDLDSSTEITVFAPESLKSIAWNGEKVKASSKQGHKYTIKIKGPSKVTLPNLDSWKYADSLPEIKTNYKTSSSAWVVADKKNTTNAVLVPDLKNPVLYVDEYKIHYGNHIYRATFPTTSSAPTGVYLNLTGGMAFGYSVWLNSDYIGSYLGEATTGHAGQEFSFKNATLSKKENVLVVLMDNSGHDLRDGALDPRGITNATLVGPAKGGYKFSEWKIAGHAGSVEGQVIDPIRGPLNEGGLYAERIGAHLPGFSDKKWKSYSSKQGTLVNPSAGVRAYRTTVDLDIPDGLDVGVSFKLTAPSNTTFSATKKGYSNQVRVLLFVNGYQYGRFNPYIGNQISFPVPPGVLNYNGENTIAVTVWSQSAQGGEVKVEWEVDYAHTSSFDVKFDSKYLRPDWTKERLQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP84</accession>
    <name>S0EP84_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438260.1">
        <property type="nucleotide sequence ID" value="XM_023571209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP84"/>
    <dbReference type="STRING" id="1279085.S0EP84"/>
    <dbReference type="GeneID" id="35407605"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14153"/>
    <dbReference type="HOGENOM" id="CLU_1129098_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="1">
        <location>
            <begin position="12"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="275" mass="30383" checksum="F8218ED76E272692" modified="2013-09-18" version="1">MAILPAVPAFSTAIIVNGEPADEYQPPCPIPYDAEFEGVPRTRCFIPAETGNTYCVRFRLSPRFGFGDETDTLLVAIYIDGALAEETIVYKELLREQDFIDYIKYRRGSNSWHEFCFQDLAPVECTAAATLNADMQLVKTLGTIRVVLKLAKNFGKDPSAQPSLEEKVCGSLDPSWKALALNGHGQTHGTGYVKVDVDIPISYYAIDTRETIGCFDFVYLSPDTLKAQGIMDPKFINQAAQGMPQTIEPAPEPPRFPTRILSNGCLEIDLTGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHY2</accession>
    <name>S0DHY2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_01890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="2"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423702.1">
        <property type="nucleotide sequence ID" value="XM_023573674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHY2"/>
    <dbReference type="STRING" id="1279085.S0DHY2"/>
    <dbReference type="GeneID" id="35395373"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01890"/>
    <dbReference type="HOGENOM" id="CLU_047845_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="109"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT61621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="310" mass="34491" checksum="1459BAD7AF99DF64" modified="2013-09-18" version="1">MTSKRSSRLFVDEPTHTREGQQTPNATQFRSRQGSRSSAREETMQEVEEALFNGHDATNVSRSGSLSAVNMEASLSTSSRTSNSSASSTSAYQSQSTDYTAPFNGRPHNFGVVIPGVYRSSFPRSHDFEYLKGLGLKTIVTLVKKDELDHDLETFVQREGIRQVVFNMKGTKKEAIPLGTMKAILSIVLDKSNYPLLIHCNHGKHRTGCVVGVVRKIAGWDAESVVAEYKSYAEPKARECDVNYLDDFQVSSLGISNPIPSMTKDVCKNRSRFQPRTFFRAVFLSAFVLLLFFMSGSKLSTATRPDHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI83</accession>
    <name>S0DI83_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423867.1">
        <property type="nucleotide sequence ID" value="XM_023575528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI83"/>
    <dbReference type="GeneID" id="35395209"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01724"/>
    <dbReference type="HOGENOM" id="CLU_105974_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT61786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="162" mass="16738" checksum="99FBA0308E6B9951" modified="2013-09-18" version="1">MPISIPLPSLVATATGITGSAYASGFIASLSLAGIPSALQLSGPPAVSVWQVLFNRGFALMPKFAGTTAIAYLYAAYTAHQQGRNWKGLAASAALTVSIVPFTIIFMSSTNDLLFKASAGTLDASQEDVATLIGRWGVLNLVRSLLPLAGAALGFSTLFSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK33</accession>
    <name>S0DK33_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to nicotinamide mononucleotide permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_01840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423763.1">
        <property type="nucleotide sequence ID" value="XM_023574251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK33"/>
    <dbReference type="GeneID" id="35395323"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01840"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT61682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="511" mass="56793" checksum="71DE006FAABA34FC" modified="2013-09-18" version="1">MAVSDRDQEKGFDERSEMKGGVINDYHDAAGHGHTATDAYGNSLVQFDPAAERRLRWKLDLYTVPTVAVLYLFCFIDRANIGNARIAGLTEDLKLVGYDYNKILSVFYISYIIFEIPATVCCKWMGPGWFLPATSLAFGIVSVATAFVHSQAAICGVRFLLGIFEAGMLPGIAYYLSRWYKRSELTFRLSLYMVMAPLAGAFGGLLASAILKLPHFGSLHHWRMIFAIEGIITIGLSLIAFVTLTDRPETARWLTQEEKDLCIARVKSERLAQTEVIDGIDRVKLWRGISNPVTLQIAFIFLFNNITVQGLAFFLPTIVGAIYPEYSTVQKQLHSVPPYAVGAVFAVAFPALSWYLDRRQIFIILSAPTVIIGYAMFLASETPSVRYGACFLIASTCMVLGTMTNAHISANVVSDTARSSAIGMNVMFGNIGGLIATWSYLVKDAPNFPIGNGLNCATGSMIFILSISGYFWMKWDNNRRDKKNVEQELAGLSPEEIANLDWKHPGHRWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKB2</accession>
    <name>S0DKB2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to F1F0-ATP synthase subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424897.1">
        <property type="nucleotide sequence ID" value="XM_023573120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKB2"/>
    <dbReference type="STRING" id="1279085.S0DKB2"/>
    <dbReference type="GeneID" id="35394079"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00594"/>
    <dbReference type="HOGENOM" id="CLU_083674_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT62816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="197" mass="20919" checksum="121C0C0AF7FABB0C" modified="2013-09-18" version="1">MSSLARPMLRSPALRVAARRFESTAAQKATENAKQAASKATENAKLAASRAQEGLSRVTTAAGPAIAGYAKGVASTLGKVGGRTGKVIGFIERQVPFVVYYSKVALELGKFVFHNQKMSPPNLATFQNTYQSIIKSIQNRTIIQSSQNAIQQVRNIGPAQLAAGGVVAAEVLGFFTVGEIIGRFKLVGYRGEASSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLJ9</accession>
    <name>S0DLJ9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424318.1">
        <property type="nucleotide sequence ID" value="XM_023581061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLJ9"/>
    <dbReference type="GeneID" id="35394713"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01228"/>
    <dbReference type="HOGENOM" id="CLU_040692_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="46730" checksum="483D9159768C2D5E" modified="2013-09-18" version="1">MDSNTTDGTCDNPSSPPTRSTVGSQVSVSGEFVLGSNISASPQTHTLEISPQPPVPSPNHYSSTPYLNTPTPESTYLSTPASQSYSQFPTLASAGIDSTWSQPNQAQEEPRSLISFPQEDRHQLVPNSRQAGRSTSMSTVAIQFDPAFTMGPRSAFTWPGPLETSNSGNSLLSPGLPSMGHVSGSSLTPPPQSRSVTSSPPRLSLSADQREVKRQSDRARRDSRLVNRMRRANSNPYVDSSPSALGLATTTAAMNISAYTTAPAPVTLMSDTPTTMSSSTYLQSYSPSLEDHQTQSAPVYPTSYPQSLQANYNMPVDYAAVYAGSSQYSTRPPPVPVGQDVGFMYQVPTVLGPGGANTQEAGHVRVVQSRPKPRCWEHGCNGRQFSTFSNLLRHQREKSGQAAKASCPNCGAEFTRTTARNGHLLHDKCKGRRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLZ3</accession>
    <name>S0DLZ3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425546.1">
        <property type="nucleotide sequence ID" value="XM_023573516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLZ3"/>
    <dbReference type="STRING" id="1279085.S0DLZ3"/>
    <dbReference type="GeneID" id="35393722"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00237"/>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF13">
        <property type="entry name" value="MITOCHONDRIAL 2-METHYLISOCITRATE LYASE ICL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="483"/>
            <end position="487"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT63465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="598" mass="66432" checksum="A03EB2C0BA7C2D18" modified="2013-09-18" version="1">MLRRLSTRAPQRLLSASKPRSVAPLFAVRAISTTPVAKMSQLSTHATQPADAFQLLPESQKAGEAEDRLYEATVKEIEAWWASPRYQGIKRPYSAEDVATKRGTQKVQYPSSVMAQKLFNLIQERVAKGEPIHTMGAIDPVQMTQQAPHQEVLYISGWACSSLLTSTNEVSPDFGDYPYNTVPNQVQRLAKAQNMHDRKQWDLRRKMTAEERTKTPYVDYLRPIIADGDTGHGGLSAVLKLAKLFAENGAAAVHFEDQLHGGKKCGHLAGKVLVPVGEHINRLVATRFQWDVMGCENLVIARTDSESGKLLSSAIDVRDHEFILGVSDPSIEPLAETIQAMEAKGAVGAEIDAFEAQWIKNTKLVTFDEAAVAHMKKEGVSQAKIDEYLAETEKDRDMGISRRRGLANKYTKEPVYFNWDVPRTREGFYHYRAGMQAATKRALAFSPYADLLWVETGDPNVEVATKLGRAVREVNPGKGLVYNLSPSFNWMAHGFTDETLKSFIWDIAREGFVLQLISLAGLHSNATITTELSREFKKDGMKAYVDIVQRREKDLKCDVLTHQKWSGASYIDGILGAIQSGSSSSKSMGEGNTEGQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMB7</accession>
    <name>S0DMB7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424593.1">
        <property type="nucleotide sequence ID" value="XM_023569552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMB7"/>
    <dbReference type="STRING" id="1279085.S0DMB7"/>
    <dbReference type="GeneID" id="35394418"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00933"/>
    <dbReference type="HOGENOM" id="CLU_069672_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484706" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="262" mass="27308" checksum="48E632C759C13F84" modified="2013-09-18" version="1">MQFTVSAAALMAFAAKALAQVADFDPVLTPTNWEEVSAGSTLDITWQAKPKYSGEKISISLIGGATQNTQVPIKTIATGIDNDAASYSWAIDSTLGTENVYGLVLKLESNPEVFQYSFPFKIEGGKKSEEKPSQTKNDYEVPSSVAPKPTKPAYPVPETTVVAVSETVTVPCNNTAGSPTTFVPVVKTHYPAPPAPPAHNGTAPNPPVYTHPAQPPVVPTQPAGQPPVYGKPTPTPVPVSGAARFGAPIAVVAGLVMAAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMS3</accession>
    <name>S0DMS3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423939.1">
        <property type="nucleotide sequence ID" value="XM_023576351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMS3"/>
    <dbReference type="STRING" id="1279085.S0DMS3"/>
    <dbReference type="GeneID" id="35395135"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01650"/>
    <dbReference type="HOGENOM" id="CLU_054057_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="477" mass="52547" checksum="994CB78BE3D576C5" modified="2013-09-18" version="1">MGRPKSRRALSASRFQEGSMNDRTSAAPPVHFLGPEERAALERPALTNIKSNNSRPMSDDFSDKQVKRGRLLGQVWDEVRGRLGFKRDNEEERGTRKRSRSRKRDQSEQRGRQRERENGSRDRPAELKTAEDTPREDMPSREEILANYHNLMASGFFSSHAIQSTRQPPPGSIQASHHLSAPPHPTSLRDALSRATTPQDGIPRAPNYDAPSPPKSPTKIKHLQKHHLRPDGPGAATYEELVASGFFTPPISDSAPPPTPIGAAPAPTVYTGRMSRDYLQPPRQTRGSRAATPSASRAPSPIRSPASASSRGTKRAAADSNSEDEEENASRDPPTPKKKLRKSASRDITLPKLRNVASRRNMLSSRRSVSGPHGASKEYNTLARRVLGRLPGGGGRGSLDIDRRPASASRRSIEESRQPLQEVQYTRILRSRKSAAEGLSVVPNANRGIPKVPNIPEKFAAYDEDAENTAPAIRSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNM0</accession>
    <name>S0DNM0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426260.1">
        <property type="nucleotide sequence ID" value="XM_023572067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNM0"/>
    <dbReference type="STRING" id="1279085.S0DNM0"/>
    <dbReference type="GeneID" id="35398106"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04625"/>
    <dbReference type="HOGENOM" id="CLU_029043_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494998" evidence="3">
        <location>
            <begin position="37"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT64179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="518" mass="57489" checksum="C8967A64D398B6B4" modified="2013-09-18" version="1">MAEPGSPGWKWFPNVKANWSLDVVTLLAVIGESSMAEQTQTITASLLCLLPRLIPAPQALLKPSRPSRMPETLAKMTGVYSGTTLDSVGFFATIITPLDALQPFSFRVLEITHTDPSFGDIDMNPPSAQESWSTRSLNWVRSRRSNSDTTEKLPNEKDPQSSRIPRAPHIEDGGLPLPNTARTTTFRPPGDSSPSNADAPKPLARRPTAKQKVQDMLANPTFANTKRRPAVPAKLFSPIHILSVFSCLLSIAIITCAVVWQDGNAILAVSLISFASTVVGYASFWHPILMNRKHTNEVPRGDVMIRTREGAFLLIKCTEEVARELYSGTEECHYHVGGRTYRLLMALGTTLLMLSVVLLGNCTWNSQIFIGGSYIVLNGLYWGLGMLPRSYFWDLSRYQWQDVTPEDAKNANEVTDVNEQREGYPSFTRTLWFAIRETQLTGWVGRSGAAPGTKQWNKWLKEALQNAKDGNRSWDSVARKDAIMKESLSADEIPDEAAQHAPAVEVQNSPTEKDRTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNN0</accession>
    <name>S0DNN0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to U1 snRNP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426275.1">
        <property type="nucleotide sequence ID" value="XM_023572086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNN0"/>
    <dbReference type="STRING" id="1279085.S0DNN0"/>
    <dbReference type="GeneID" id="35398090"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04609"/>
    <dbReference type="HOGENOM" id="CLU_013872_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000035">
        <property type="entry name" value="Putative ff domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT64194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="566" mass="64593" checksum="80AD56A2FCBB8707" modified="2013-09-18" version="1">MLKSTHTPSAAALAPLPPGWSEHTAPTGHTYYYNAETKESTYKRPGAQPPPQPAQPPAPAYPGYGSIPYLADPNVANAYMAQFNQDNDGQRYNNSSRGGHGGGRGGFEGRPRPQPVDKPRKKEPIPGCEPWILVYTKYSRRFVYNPIKNASYWRIPEKLMPAILELDKARLRQKATGESQGKENKQDEKQPEQAIPQKKDDAPVAGLDDDSEYEEVEVTDDEGDDEGDGEHPSKRQRTADPGADEDFPMEFTEADFAAQLQAMGDDYGLEPGDYDDGNAEEWPEGAEGVPLSVDDAKYLFKDLLNDFNINPYSPWEKLLEEGKIIDDLRYTALSTTKARRDCWDEWTREKIAELKEQRARQEKRDPRIAYMAFLQEKATPKLYWPEFKRKYKKEDVMKDHKITDKDREKAYREHIGRLKMPQSKLKSDLTALLKAQPVHLLNNKSLSTGLPDPVLTDIRFISLEPKIRDPLIEAYVSNLPPPPEDLDAAKDDEEQRKQRESREKREKALEERNRVVEEQKKKRDREVAASKARLRDEERELEMAMKVGKQGLQSQLASMKVAEKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP27</accession>
    <name>S0DP27_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative aldehyde dehydrogenase FUS7</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fusarin biosynthesis protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04618</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative aldehyde dehydrogenase; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C. Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production. The other FUS cluster members are not essential for fusarin C biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426267.1">
        <property type="nucleotide sequence ID" value="XM_023572075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP27"/>
    <dbReference type="STRING" id="1279085.S0DP27"/>
    <dbReference type="GeneID" id="35398099"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04618"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00078750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT64186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="509" mass="54343" checksum="5A37C20DC51E04CF" modified="2013-09-18" version="1">MTFSSEIHTFHSGRSQPESSSKTNTFVSVDPSNAKPLATIYTTTPEQLNSTIAAAQAAFPTWSQTPAPRRAAILLKAAAILRERNDELALTETLDTGKPWSETSTVDVATGADVLEYYAHIAAGSFPGQNTRLRPDAFVLTTHEPLGVCAGIGAWNYPIQIALWKSAPCLAAGNCMVYKPSEVTPLHAQTLAQIYIEAGVPPGVFNVVYGDGIAVGAPLVAHNDIAKVSFTGQVSTGSKVASQAVKDMKGVTMELGGKSPLVILPDADIEEAADTAMVANFFSTGQVCTNGTRVFVPDILLSQVEQAIVQRCREGIRMGLPQNGETNFGPMVSAAQQEKVKMYIQHGRTVDKAKVLFDGSAEPSMTQPTSDGFWVHPVVFTNCTDSMRVVREEIFGPVMCILPYSTQGRPRQEWVSELIARANDTPMGLAAGVVSSDVGLAHEVVQKLDAGITWINTWGESPAEMPVGGWKMSGIGLENGHEGIAAYMRTKSTLVQLGKGACKGVFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP69</accession>
    <name>S0DP69_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424454.1">
        <property type="nucleotide sequence ID" value="XM_023567897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP69"/>
    <dbReference type="STRING" id="1279085.S0DP69"/>
    <dbReference type="GeneID" id="35394567"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01082"/>
    <dbReference type="HOGENOM" id="CLU_005537_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="839"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="904"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1149" mass="126396" checksum="F3BEB2D34C7B01B9" modified="2013-09-18" version="1">MASTFDVPPSSLHDKDTQPFPTSNQQAPTSAFNSDQLPATLSRVDSDSLSPINYLETPDSTSSLGHYQASDFSDLDDDPFFGADFNADGGAPNFLEQDLNGLDQSFTPGLMPDKDVDSGTYPLTPEQTASVHATPPQGDLSYAIKGSAPSALPNCISPQEIQKRFNPHPINTQTSELTPSHSSSCRSSEDGLAPGIATMTSPRVTVSMWGNHDETPVHTSVERSFEDSPTTVRGGFEYAGDLISPGDNSSVRDSAGRWQQNPSTGQSGLDPNNRPSNEVPSINELATRRDDDERKEMVGDWLADKMNDLSVKPDDNSRDQINELDSQRDDPHDHVIPFGRETENKFVPGQTYYRAQGEMNQQDRDIIAANRNWADAPMFPCISRGEPGRNQPESSAAAMERFERMCRDTDSILSRAATWGTRRRSLPSVFDLDMTDGTSGGILKKLSSSRESRSSKPGSLLRDLRGLVRRPSASRLKRTLSSGNDEESLPSSEGRGSQDSKRDSISKRGDSVSHLAPPNRIGSWGKKPMPSINTAIASMGSNIASIGTTHARSGSVSGSGTPGGSITSPKSPFSGLSVKKSIRRPRSKSELPKATPVGMQTESHPTLVSMWKRETGGPPVAALAKTKHADLDDDDDDDDDFSDEADMRTNPNIIDNITPNLEGFQQHIIDLNPGLATSNTFLVDRIAYHQVQRYKYLLKNKVAHIGLGAACNSGIMCVSRGGSATLLDQNKNVRELDPLSSPNDDEDGSPVEGAINTESFPQDIPMPPTSHLPAEFECRLCFAAKKFMKPSDWTKHVHEDVQPFTCTWDKCPGPKMFKRKADWVRHENEGHRQLEWWTCDVEACHHQCYRRDNFLQHLVREHKYPEPKVKSKAAVKKAGGSEPTWQKVEQCHHETTKKPHDEPCRFCGKTFPTWKKLTVHLAKHMEQISLPVLRLVDAKASELSADTVISPVQDPPPRNILTTPIQTNMPTQYPVGGQHQQIPQATPQIYENHSQNQMAYPVMPTEAYHHQQQQQGFYTDQYTNASNAPHNFPSTHAEMGMHPMNNQSFNTAPMQEMVASSAGYQQNAFMMPNSGLETYNQMNPLGLQSHAMPMGQMGPMVYDGITDPSSGNGSPFSGQGSMSPYSHSPNLNANTGNGMWGDRRMAGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPJ4</accession>
    <name>S0DPJ4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424564.1">
        <property type="nucleotide sequence ID" value="XM_023569208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPJ4"/>
    <dbReference type="GeneID" id="35394449"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00964"/>
    <dbReference type="HOGENOM" id="CLU_047429_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="369" mass="41196" checksum="B88A937858396214" modified="2013-09-18" version="1">MEFHSSEPATEPVRFRTGKKRKAYRQRVQQDDASVAETIQSHPTASASEPSHELSRNASPDRAQDEEESVVAALKLRNARRARLGGVAFRNTNRPDDDMNNERALIPHDADGTSNNEPTVKGVADRFTHQTGRLTDLNDKHMMDYIESRLYNRAGGNTSHNTLSASTSDPARQPSATTTTTTTNHESGRAVMQGQLVEISLEDHSARGKNPVQADSATDGGPRAKKPRLRKDGTPWRPRNRRDSDALKRDQIVDEILHETRRMSLMSMFLELATKSLFLVDLYEPTPGQDSHTAVADQDGAADARLAEEFRQQFLEDVAERQLRKKKATNQTTRPGTEEVLKGPKLGGSRNARAQMRDLLLKKEKEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPJ7</accession>
    <name>S0DPJ7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425408.1">
        <property type="nucleotide sequence ID" value="XM_023573739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPJ7"/>
    <dbReference type="STRING" id="1279085.S0DPJ7"/>
    <dbReference type="GeneID" id="35393524"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00039"/>
    <dbReference type="HOGENOM" id="CLU_059964_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000004">
        <property type="entry name" value="5-keto-4-deoxy-D-glucarate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF9">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="269" mass="29054" checksum="A8BDF72C937D8CF3" modified="2013-09-18" version="1">MTQKTYPTALTTTIENPRLRFLNKIKAGEFPLMTFVAIPSVRQAQIVALTGLDGIILDCEHGHIGDDSMHNSVAAISALGVSPIIRIRGPAHDIIKRALDTGAHGIMVPQINNADEARQIVASSKFPPQGVRGQGSAFPAIGHGLTTPEYMKSANETIITMIQIETRAGVENVDEIAATPGVDMLFIGPNDLAQSLLGYVPARGDEPEFVAAIDKIINAGRRHGKWVGRMVNNGSVAKEERSRYDTVAITGDTKAIQNWYMAEFDIARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPY0</accession>
    <name>S0DPY0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mating-type switching protein swi10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426690.1">
        <property type="nucleotide sequence ID" value="XM_023572595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPY0"/>
    <dbReference type="STRING" id="1279085.S0DPY0"/>
    <dbReference type="GeneID" id="35397634"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04153"/>
    <dbReference type="HOGENOM" id="CLU_052531_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48237" checksum="EC12551396EB6569" modified="2013-09-18" version="1">MDNTLTRSHSLKPPRRKLQKPDPKLKSLNKAKRGSTDSTMSSLSPQSTMSSPSQRQIQNGAPDLSDSKWDHYLRPKTVFVPSFSEPEDHLQPEINSPYEPPQQQQQHHQYQHEPEPEPPRAFFSPPPRRQSSQRQIPEFHHLTLQDHHARPSLDSSSLPSTASTTSTSSIMRRQAKTPVFRIGQLEQHALARKARDVPEKTSSVELIADQYNAVLESRDGPPALDSQLPSRASTYSFDDTPLQISPHGAKRQSLRSSNTYSSMTAIPRQLRPRLRSAATHDTNVAAVEGDTIYFKPYSFSPPPSPDQTPGTPRGSWTDEFRPPSSSGHSFQENISLQIALDLLTSELSSVVSGRPQRNGQDTAALQVWVMIEAYERLRDQLTRQQSSNAEAQKVATMFDCWLASLYSIHSSLTESTLPSPTEYAGLEEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQK8</accession>
    <name>S0DQK8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426792.1">
        <property type="nucleotide sequence ID" value="XM_023572720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQK8"/>
    <dbReference type="STRING" id="1279085.S0DQK8"/>
    <dbReference type="GeneID" id="35397522"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04041"/>
    <dbReference type="HOGENOM" id="CLU_028866_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000911">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="363" mass="40258" checksum="5E07003539B2AE32" modified="2013-09-18" version="1">MSSTSDRILRVGIIGCGEISQVAHIPNINFLSHKFQTTYLCDISKQALAHCTTKVQGGTPKTTTNPEELCSSPDVDVVLIANADAYHVEHGILALKNDKFCLIEKPAATCFRDIDRLIEAEKASKGKVFVGTMRRYATAFIDAVAEVGAMEKIQYVRVRDIIGPNSTFVEQNGTFPQKFNDFSEEDGQDRSRREADIFEQALVKEFGVSSTPHLGTHDLSAMREILGMPKFVAGAVLTLPGIFSVLFQYDDFPVTYESGLSGVPQFDAHIEVYSANKIVRVNFDSPYVKGLPVIMTIREKIGEGGFQERIIRKTYEDPYTLEMLDLYDCVVGGKVPKTSATDARKDVELFEMILKAGADRFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQR1</accession>
    <name>S0DQR1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426852.1">
        <property type="nucleotide sequence ID" value="XM_023572793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQR1"/>
    <dbReference type="GeneID" id="35397456"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03975"/>
    <dbReference type="HOGENOM" id="CLU_804212_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="345" mass="37086" checksum="8FA5FBD439304277" modified="2013-09-18" version="1">MSFTAFNSYQLDTSDILDAPGIEPSNDYYQFSPFNTCQVPGMAQYGMNSAEDLQEVEESKSNARLKLGYKRASSACKQCRHRKIRCIASSSDAQARCVSCVRLKKECSSYLTGQSSTEGSSLVRIARFSPGPDPGLLPYNPARNSETVDRYLDGIKSSLNPSEIRPTPPVVPVSTGIPWTDGFAPDMRVSTVANPANLIMRSQSLPGKSGRVLGQDLNSNAAGFDSTQGAQLSEAPAMSQFSTLAEMSSPSTSSVSDSANPLFHPDFGIPWDSNSHALPMRFMPGLSDSANMGDMFIGGGGDVFDFNSGPGPSTNQPLPLQVNPVIQGRSQSLPYNGYAVNTYWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRI6</accession>
    <name>S0DRI6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425254.1">
        <property type="nucleotide sequence ID" value="XM_023573552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRI6"/>
    <dbReference type="STRING" id="1279085.S0DRI6"/>
    <dbReference type="GeneID" id="35393690"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00205"/>
    <dbReference type="HOGENOM" id="CLU_019833_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="692" mass="78029" checksum="635E74A41561D3E1" modified="2013-09-18" version="1">MQGNYRKIQPAPRDDADEIDRKFRVAKRKRQHVRIACNPCREKKRACNGIEPTCDQCQTRSLACIYRIPPKTVDSTIKIQKQLDTLQHSFNHYADLVEQLKTLPEKDALKLLQRLRSPADVNGAFASLQGSVNTRIRLSNHRTAQAVLPTTNSRVEFELTALHGIVYPTLVPIDITSLGVSPLEKPALPTTQTGTLVHKISPASPIILSSDRVRSLCDRRLEEVDISYWTKVPISNETAAAMISLFLETDQTIVGFVDADLFVESLVERKPQFCSTFLVSAILYVVCHAFTAFDLESVAVGRLCFQETERLFRAEGSFDDLITLAAINTFSLACRFHGHEGLAQELVAAARHMGRRLGLYGVPLDSPSSLAFQELPDDLVRMTAHVAWGTYNWLTIHVLYFHDESIAIPPALPIPGHERVDDPWPEHPLPEYMGSSFTKLCEFFTVIQEVAVVYSIADGTPVVDRVPIAFAEAKYQKILAWADSLGKDMAWDQNSQEHVMLFHMWFHCAVLDIFRPFAHGGHKTYTLRSFSSQDSTPKTIFSASLNQLKRLALLYRTQQMPNSYMPYINISLIHIANTICRETNDPTAKFYFLLCIRYWQHLYVGYPIFGGIAQAFLTMAINNGLITNREAKRLMAEVKGQGGHHDEGISTSLIVDFDLAMTNRDEADVQAVAQKFEEVALFDEFAVYKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRP9</accession>
    <name>S0DRP9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_00131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
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                <person name="Sieber C.M."/>
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                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
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                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
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                <person name="Wingfield B.D."/>
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                <person name="Freeman S."/>
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                <person name="Proctor R.H."/>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
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                <person name="Michielse C.B."/>
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                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
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    <reference key="2">
        <citation type="journal article" date="2006" name="Planta" volume="225" first="223" last="234">
            <title>Fusaric acid induces apoptosis in saffron root-tip cells: roles of caspase-like activity, cytochrome c, and H2O2.</title>
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                <person name="Samadi L."/>
                <person name="Shahsavan Behboodi B."/>
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    <reference key="3">
        <citation type="journal article" date="2008" name="J. Appl. Microbiol." volume="104" first="692" last="698">
            <title>Bikaverin and fusaric acid from Fusarium oxysporum show antioomycete activity against Phytophthora infestans.</title>
            <authorList>
                <person name="Son S.W."/>
                <person name="Kim H.Y."/>
                <person name="Choi G.J."/>
                <person name="Lim H.K."/>
                <person name="Jang K.S."/>
                <person name="Lee S.O."/>
                <person name="Lee S."/>
                <person name="Sung N.D."/>
                <person name="Kim J.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1111/j.1365-2672.2007.03581.x"/>
        </citation>
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    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Arch. Pharm. Res." volume="34" first="1177" last="1181">
            <title>Antimycobacterial activity of fusaric acid from a mangrove endophyte and its metal complexes.</title>
            <authorList>
                <person name="Pan J.H."/>
                <person name="Chen Y."/>
                <person name="Huang Y.H."/>
                <person name="Tao Y.W."/>
                <person name="Wang J."/>
                <person name="Li Y."/>
                <person name="Peng Y."/>
                <person name="Dong T."/>
                <person name="Lai X.M."/>
                <person name="Lin Y.C."/>
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            <dbReference type="DOI" id="10.1007/s12272-011-0716-9"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
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    <reference key="5">
        <citation type="journal article" date="2011" name="Toxicon" volume="57" first="176" last="178">
            <title>Phytotoxicity of fusaric acid and analogs to cotton.</title>
            <authorList>
                <person name="Stipanovic R.D."/>
                <person name="Puckhaber L.S."/>
                <person name="Liu J."/>
                <person name="Bell A.A."/>
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            <dbReference type="DOI" id="10.1016/j.toxicon.2010.10.006"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
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        <citation type="journal article" date="2012" name="Planta Med." volume="78" first="1562" last="1567">
            <title>In vitro acanthamoebicidal activity of fusaric acid and dehydrofusaric acid from an endophytic fungus Fusarium sp. Tlau3.</title>
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                <person name="Boonman N."/>
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            </authorList>
            <dbReference type="PubMed" id="22864988"/>
            <dbReference type="DOI" id="10.1055/s-0032-1315146"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
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        <citation type="journal article" date="2013" name="Planta" volume="238" first="727" last="737">
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                <person name="Jiao J."/>
                <person name="Zhou B."/>
                <person name="Zhu X."/>
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                <person name="Liang Y."/>
            </authorList>
            <dbReference type="PubMed" id="23838885"/>
            <dbReference type="DOI" id="10.1007/s00425-013-1928-7"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
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            <title>Contamination of bananas with beauvericin and fusaric acid produced by Fusarium oxysporum f. sp. cubense.</title>
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                <person name="Li C."/>
                <person name="Zuo C."/>
                <person name="Deng G."/>
                <person name="Kuang R."/>
                <person name="Yang Q."/>
                <person name="Hu C."/>
                <person name="Sheng O."/>
                <person name="Zhang S."/>
                <person name="Ma L."/>
                <person name="Wei Y."/>
                <person name="Yang J."/>
                <person name="Liu S."/>
                <person name="Biswas M.K."/>
                <person name="Viljoen A."/>
                <person name="Yi G."/>
            </authorList>
            <dbReference type="PubMed" id="23922960"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0070226"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2014" name="Appl. Microbiol. Biotechnol." volume="98" first="1749" last="1762">
            <title>Characterization of the fusaric acid gene cluster in Fusarium fujikuroi.</title>
            <authorList>
                <person name="Niehaus E.M."/>
                <person name="von Bargen K.W."/>
                <person name="Espino J.J."/>
                <person name="Pfannmueller A."/>
                <person name="Humpf H.U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="24389666"/>
            <dbReference type="DOI" id="10.1007/s00253-013-5453-1"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2016" name="Environ. Microbiol." volume="18" first="936" last="956">
            <title>Two separate key enzymes and two pathway-specific transcription factors are involved in fusaric acid biosynthesis in Fusarium fujikuroi.</title>
            <authorList>
                <person name="Studt L."/>
                <person name="Janevska S."/>
                <person name="Niehaus E.M."/>
                <person name="Burkhardt I."/>
                <person name="Arndt B."/>
                <person name="Sieber C.M."/>
                <person name="Humpf H.U."/>
                <person name="Dickschat J.S."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="26662839"/>
            <dbReference type="DOI" id="10.1111/1462-2920.13150"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">Hydrolase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:24389666, PubMed:26662839). L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism (PubMed:26662839). The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and linked to the NRPS-bound amino acid precursor by NAD(P)-dependent dehydrogenase FUB6 (PubMed:26662839). FUB1, FUB4, and the non-canonical NRPS Fub8 may form an enzyme complex (PubMed:26662839). Further processing of the NRPS-bound intermediate might be carried out by FUB6 and the sulfhydrylase FUB7, enabling a spontaneous electrocyclization to close the carbon backbone of fusaric acid (PubMed:26662839). Dihydrofusaric acid is likely to be released via reduction by the thioester reductase (TR) domain of FUB8 whereupon the final oxidation to fusaric acid may (also) be performed by the FMN-dependent dehydrogenase FUB9 (PubMed:26662839).</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="9">Expressed under high amounts of nitrogen via regulation by AREB (PubMed:24389666). Moreover, components of the fungal-specific velvet complex VEL1 and LAE1 act also as positive regulators of expression (PubMed:24389666). Finally, the pH regulator PACC acts as activator of FUB expression after the pH shift to alkaline ambient conditions (PubMed:24389666).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="9 10">Impairs the production of fusaric acid (PubMed:24389666, PubMed:26662839).</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="2 3 4 5 6 7 8">Fusaric acid is phytotoxic to plants such as cotton and banana (PubMed:20955724, PubMed:23922960). It has been shown to induce programmed cell death in plants (PubMed:16868776, PubMed:23838885). In addition to a mild toxicity to animals, fusaric acid exhibits acanthamoebicidal, antioomycete, and antimycobacterial activities (PubMed:17927749, PubMed:21811925, PubMed:22864988).</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the AB hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="13"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRW4"/>
    <dbReference type="SMR" id="S0DRW4"/>
    <dbReference type="STRING" id="1279085.S0DRW4"/>
    <dbReference type="ESTHER" id="gibf5-fub4">
        <property type="family name" value="FSH1"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CCT65186">
        <property type="protein sequence ID" value="CCT65186"/>
        <property type="gene ID" value="FFUJ_02108"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02108"/>
    <dbReference type="HOGENOM" id="CLU_051938_4_1_1"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-19343"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000437315" description="Hydrolase FUB4">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16868776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="17927749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="20955724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21811925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="22864988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="23838885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="23922960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="24389666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="26662839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="24389666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12"/>
    <evidence type="ECO:0000305" key="13">
        <source>
            <dbReference type="PubMed" id="26662839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT65186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="267" mass="30933" checksum="08BEA25A6EBF292D" modified="2013-09-18" version="1">MRFLCLHGYAFSVEVLQQQMEPITAHLPSDWEYEFLEAGMEPTELMLPNLKQVPKPNYSWYNFPYPEDVEEAYERLAAYVESDGPFDGVWGFSQGGSMAALLLLMHQAEHPDTPYPFKMAIFTSAFLPHSFDNGVVSWDLTEKNTLEPTYLPGRIDVSHGKKLDWKKDLHTSIEYDMINAVKDELDFPVDLLLRWRPSDIPEKIPVPSVHVRGLKDHYSFVDESVYELFDPDMARKMTHRGGHNFPRYNEELVHFAELIIDTVVSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS94</accession>
    <name>S0DS94_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to SRP40-suppressor of mutant AC40 of RNA polymerase I and III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425519.1">
        <property type="nucleotide sequence ID" value="XM_023570552.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1279085.S0DS94"/>
    <dbReference type="GeneID" id="35394328"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00843"/>
    <dbReference type="HOGENOM" id="CLU_398527_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053263">
        <property type="entry name" value="Euk_RPA34_RNAP_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155">
        <property type="entry name" value="ACR243WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="636" mass="68048" checksum="13F1BD9A74762AB8" modified="2013-09-18" version="1">MAPKEPYKVHSLNKHIENTKKGLSAEAQFNRRPGNRAATIKKESSDPNNIFANNNGDDDDESGSGSDSDSSSDGQADFISKLTSTAKPTSATPRRRSKDDEIADSDAERNTSKKSTIVKKPAPAKSKPQSSSDSSSEDESDDEKTKAKTNGTTPAKASESTSSSSESESDSDSDEEDDKAPKPSTKKQQPSASTSEDESDEADAKAKPPLNGKAATTSDSSSEDSDNESEDEKQSVKLAAKTPAKPAAPEPDSSSSEEEDSDDEMVDESMHIEDREGQLALPNFIAPDFVLRKGDDGTNGRDVAEICNKANLEGKQFWYFTVPSNVPISVVQNLEIPMNQSQSTDKLFSHNGEDYGVSFESIAPKGNIQIMIPSDRPQYQPVTKQIDQVMQVKKITQLGSTKSVAPVPKPAPRAQPAGLKARYQPIGVNEPMGSIGDDEDVEMGDAPVLSTKAAKKEKKRKSKETSDKKQKKGQSIPELPSSRTTEAPTSDTRKNKRKLAASEDDAVAVAEQLQEEARLAASKSKKQKTTRDGSPDLGSEPTSAVAKKYTPVLPPAIPAVGTPTSKSASTAVASSKKQKKVKEASVPAPRQSVPPASPSQGKEKRARKRKDKDGKKTPSGKKETPVVPPVPLTSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSJ2</accession>
    <name>S0DSJ2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to transcription co-repressor GAL80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427491.1">
        <property type="nucleotide sequence ID" value="XM_023574068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSJ2"/>
    <dbReference type="STRING" id="1279085.S0DSJ2"/>
    <dbReference type="GeneID" id="35395831"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02349"/>
    <dbReference type="HOGENOM" id="CLU_023194_25_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="141"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="385" mass="42478" checksum="ECD1F429803D27CB" modified="2013-09-18" version="1">MAPIRTAIVGLSSSAKTSWASNTHLQYLNSPLGRSKYQIVALQNSSLQAAKNAIVHYNLPPETKAYGTPEDLAGDKDVELVVVATRVDVHHSSALPSVKAGKDLYVEWPLAQDVQHARELVDAAREKGVKTIVGLQGRYAPPIKKLREIIEEGRIGKVVSAELYASGGTNDREILPSSLEYFTQRAVGGNIFTIGLGHIFDQFQSIIGDITNFKSTLHNQRPNIRVRDPKTNEITHTTTSNVPDLILATGRLSESSIAQKDAAVLVRFRRGQPFPGSPHLSIAIAGEKGEIRVQVFTGTTLHGASAYEKPVVIEVHDFERDVVEQVEWKWEEWQQDIPLLARGVAAVYEAFAGREKDGLVSFEEALKRHQQLEGLLGRWDEDRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSL1</accession>
    <name>S0DSL1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425624.1">
        <property type="nucleotide sequence ID" value="XM_023571293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSL1"/>
    <dbReference type="GeneID" id="35398797"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05316"/>
    <dbReference type="HOGENOM" id="CLU_128312_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="180" mass="20478" checksum="5C589913799D5250" modified="2013-09-18" version="1">MSSTNTPRISSSLHEAASAVFKLTQHNSRLQQHQLDQALKFRQLADSLHRSIDELEVAIMHLRCVPGSEAYFYQAQQHFYSFRLIENDLNKTLASITHADFKFCQETRTTYAQFLGHISCYTGDDTQALASLKATTGLFDVFHSQQRQRLATMRDQLDSLTLVMNKMAALKHGLEEQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT78</accession>
    <name>S0DT78_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA (cytosine-5)-methyltransferase 1 replication foci domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427737.1">
        <property type="nucleotide sequence ID" value="XM_023574371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DT78"/>
    <dbReference type="STRING" id="1279085.S0DT78"/>
    <dbReference type="GeneID" id="35396101"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02619"/>
    <dbReference type="HOGENOM" id="CLU_023186_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="86652" checksum="1EA345FE20A4B437" modified="2013-09-18" version="1">MVGRPRRASTSSVDTEDESQRSWKQEKSVLRFDPGGVDSDTTFEINDAVVLNKDGHTLENALDVATRGPYIIRGLLHIEEQSQRARLIMKVRSLTPFEVRKCGQFSIGESESGSPVIWMLGACGWFELNPAPAYLPIYRKMQEAIRLYYRLMAIYRDKKPKRAKKSKKDALKELYQVFHEYAASIGDGSTLEEVITRCDDHASFLIAQCIQDQSEVEWFVTPFFKWLINRHQDLYNKELERMNNPPQPQRSPSVETSNTPVSQILTSRTRNASSAPSTARDATPDIIEPEDSPPRRRYSRSRSATHRPENTAVDLFSSTQISRDGSTRPGSVHSSASVSSVRMSQAPGTVDAKDDAFRSVLDALEWIRVEISNSRNGHLSIPAVTQRFWSNFSFPTYKGDIRPSYRVPITEVLHYNAHALLQVLNKDKYDGEFYSWLQELAQTPFNPVTIKLSDFPFYVKRRQPSNKNNPSKTTPPSQARAASRNHDGGPSTPLRSSPAGKSLMRPGRPSGIKSSLRLATTSRKRPHSEVDSDSEDEGSEPKRSHYFSGEEETMGDTSHMSLSEDEDAQETSEGPVKIYLRADNIPTTVPRGPGETWVCEEEDCGYVVRGGDIQNCRDRIRRHFNEHEQQMDRVNLARTEATRGHLPVKYAYFPPFLIVVELHPPCITQQRQSPPIDQVATAASTPTLANSPVAPSLQPRTPESSPTKTPVLASRHNFRSIVDGFRRRAHPVHLMDKLKKLGEKSQAAEQLRVNEIVLPQRIKRNLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTI9</accession>
    <name>S0DTI9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426778.1">
        <property type="nucleotide sequence ID" value="XM_023572701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTI9"/>
    <dbReference type="GeneID" id="35397539"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04058"/>
    <dbReference type="HOGENOM" id="CLU_120571_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="195" mass="22428" checksum="3DF95C79082FC62B" modified="2013-09-18" version="1">MRYAYARCIISHETTLPSTLALQFSHINYAQLYSVSLNRSIQDTDSCTFIYDQKKSIKMIFTISWTNEGDDYIFQNEEEAKFWERVVRLCSTVSPLQKRIKTELEGTAFREMLEISDQEWSETWSAGVPAPVPEITPQNQPPVSTTTVAEEGARIRRSVARFGSRFSIRVRFPRFSKKKKKKGQNEEAVKEATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTQ9</accession>
    <name>S0DTQ9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426858.1">
        <property type="nucleotide sequence ID" value="XM_023572800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTQ9"/>
    <dbReference type="GeneID" id="35397450"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03969"/>
    <dbReference type="HOGENOM" id="CLU_1023261_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="272" mass="29737" checksum="58883AF926109620" modified="2013-09-18" version="1">MSVNNGPFYSSSFPFHSPNAASSLNISFISIKALLCPTWSISSFQLIHTTSRSLTTSERTMRFIIITAIIAGCAAAGSLSKQQKPIRRPSTFQIVYNRTEKFKAANNTLYIGSPKQDACCNQFNAEDAATFYLKDEELFLYSPGNPKQQVIVNSKKAATGCEKTFTGCCTLLTIPPLGQNSVGYSIGSRKKLEKAQRQGWRIDDDDNITFDGLSLMACSSSGVGRGIIVRKSDCRLKGCRACRRVTAKATYTSHPTSCLYSGEGQVVSHFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU95</accession>
    <name>S0DU95_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prenylated Rab acceptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428102.1">
        <property type="nucleotide sequence ID" value="XM_023574813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU95"/>
    <dbReference type="STRING" id="1279085.S0DU95"/>
    <dbReference type="GeneID" id="35396496"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03014"/>
    <dbReference type="HOGENOM" id="CLU_020822_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="60317" checksum="36A06297F8699DCB" modified="2013-09-18" version="1">MSRIQIPLDVITSRLNFGDRFQGLRSGPLSGRFSNLRPVGEFLDFKRLSKPANFVEMQSRVNYNLSHYSSNYAVIFVMLSIYALLTNWLLLFDIILVVVGMWFIGKLDGHDLEIGTFRASCSQLYTALVCVAVPLGLIASPFTTLLWLIGASGVTILGGLGGRPQSPEFAPQWGRPSRRSRRRTDGDSASRGRQGRDVRVEELDSDEDARGVGASSGTRFASDSLRFTGIDLGNRERGLVRRGDYQDSEDSEDDSESSEDEEFEQYLAELAVRDREEALVQSAMHRIERAKAKGRTDVDLNEEEMGALERRRKRDEAAKKKKSGKKRKDQRVAVPLTQLEPSSRKKKAPPVSSQPRTQSRARQSSSNSNLTEDQDRSSRPSMGYFPPPATAGRPRSGTSSQRPQSRVRAPSNSRQPSDSSVIVRRGRNSSQAPLDPFQFQVPGAQASSPAGSWRQFSGAQRSSRGSRQINGSSEEGSESEDESDEEREASVETTSSDDVGSGAQIVVEESSPEPSKPEPVRRNPPRTSASSSTSKRKPAANGGRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUJ5</accession>
    <name>S0DUJ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428181.1">
        <property type="nucleotide sequence ID" value="XM_023574906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUJ5"/>
    <dbReference type="STRING" id="1279085.S0DUJ5"/>
    <dbReference type="GeneID" id="35396579"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03097"/>
    <dbReference type="HOGENOM" id="CLU_409953_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="670" mass="76343" checksum="7611AFF3697514C7" modified="2013-09-18" version="1">MPRRSGRLASRQTGDAKEHDEKRSEEEQGESSSMHAKVPQEWDDDEDDEYDDDRDTAKYTQNSLTVTYEDSEFELSEIEEDEEFLVEGELEQECFDLSELPLDPCEVPPEEPEVDDDDELETHQSNKRARISIDTAEQWISDFNRANPVNDDDPDLLRFRETLKIIVERICNWARENENGSLKAWFKSPVSERHTTSQFRSILARVDIQQLIDNLFEHMPKCVQKIFGKKNLRPMDLLDLPKVPHSFSHRLTYTDVPVRAGVNNITRLPGVRGKPVKSIKPDAQLGKEAPTKVYLGSTISKFGAYTRIRTHEAGSDGKVKEKSVHYDFTKQPDVAPNLRIVGVWSNPFVVDSLDNPNDIDRWLPVFLEGILMVYLGLVHRSNTPLIDRTLQGVFSEAKYVLIDRLRSNLELPDFHTQSLNLAWSIAQGVNGGMIVVNECSNCKRPKFFHGKKQKFVTLDGSLSDRICGACYQYARKHNGELRTSNTTHYVKSRGARVCNNPNCRKVEGSDEKGHFRTDILDKTKWRCPTCAAYQKNHNGEDRPAEQPAPAADNRSCCNPDCDRVQVPGGAKIHWKSRVTATGTVEWRCSRCSSYLKNNGVDRPSGEVKTGRKPQQAGRSCSNCGQVQDPNGKSLNWRKNEAAEGTFRCRPCHDYFTKHDGEERPQSRWTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUX2</accession>
    <name>FUB5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homoserine O-acetyltransferase FUB5</fullName>
            <ecNumber evidence="14">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Fusaric acid biosynthesis protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FUB5</name>
        <name type="ORF">FFUJ_02109</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Planta" volume="225" first="223" last="234">
            <title>Fusaric acid induces apoptosis in saffron root-tip cells: roles of caspase-like activity, cytochrome c, and H2O2.</title>
            <authorList>
                <person name="Samadi L."/>
                <person name="Shahsavan Behboodi B."/>
            </authorList>
            <dbReference type="PubMed" id="16868776"/>
            <dbReference type="DOI" id="10.1007/s00425-006-0345-6"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="J. Appl. Microbiol." volume="104" first="692" last="698">
            <title>Bikaverin and fusaric acid from Fusarium oxysporum show antioomycete activity against Phytophthora infestans.</title>
            <authorList>
                <person name="Son S.W."/>
                <person name="Kim H.Y."/>
                <person name="Choi G.J."/>
                <person name="Lim H.K."/>
                <person name="Jang K.S."/>
                <person name="Lee S.O."/>
                <person name="Lee S."/>
                <person name="Sung N.D."/>
                <person name="Kim J.C."/>
            </authorList>
            <dbReference type="PubMed" id="17927749"/>
            <dbReference type="DOI" id="10.1111/j.1365-2672.2007.03581.x"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Arch. Pharm. Res." volume="34" first="1177" last="1181">
            <title>Antimycobacterial activity of fusaric acid from a mangrove endophyte and its metal complexes.</title>
            <authorList>
                <person name="Pan J.H."/>
                <person name="Chen Y."/>
                <person name="Huang Y.H."/>
                <person name="Tao Y.W."/>
                <person name="Wang J."/>
                <person name="Li Y."/>
                <person name="Peng Y."/>
                <person name="Dong T."/>
                <person name="Lai X.M."/>
                <person name="Lin Y.C."/>
            </authorList>
            <dbReference type="PubMed" id="21811925"/>
            <dbReference type="DOI" id="10.1007/s12272-011-0716-9"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Toxicon" volume="57" first="176" last="178">
            <title>Phytotoxicity of fusaric acid and analogs to cotton.</title>
            <authorList>
                <person name="Stipanovic R.D."/>
                <person name="Puckhaber L.S."/>
                <person name="Liu J."/>
                <person name="Bell A.A."/>
            </authorList>
            <dbReference type="PubMed" id="20955724"/>
            <dbReference type="DOI" id="10.1016/j.toxicon.2010.10.006"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="Planta Med." volume="78" first="1562" last="1567">
            <title>In vitro acanthamoebicidal activity of fusaric acid and dehydrofusaric acid from an endophytic fungus Fusarium sp. Tlau3.</title>
            <authorList>
                <person name="Boonman N."/>
                <person name="Prachya S."/>
                <person name="Boonmee A."/>
                <person name="Kittakoop P."/>
                <person name="Wiyakrutta S."/>
                <person name="Sriubolmas N."/>
                <person name="Warit S."/>
                <person name="Dharmkrong-At Chusattayanond A."/>
            </authorList>
            <dbReference type="PubMed" id="22864988"/>
            <dbReference type="DOI" id="10.1055/s-0032-1315146"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2013" name="Planta" volume="238" first="727" last="737">
            <title>Fusaric acid induction of programmed cell death modulated through nitric oxide signalling in tobacco suspension cells.</title>
            <authorList>
                <person name="Jiao J."/>
                <person name="Zhou B."/>
                <person name="Zhu X."/>
                <person name="Gao Z."/>
                <person name="Liang Y."/>
            </authorList>
            <dbReference type="PubMed" id="23838885"/>
            <dbReference type="DOI" id="10.1007/s00425-013-1928-7"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E70226" last="E70226">
            <title>Contamination of bananas with beauvericin and fusaric acid produced by Fusarium oxysporum f. sp. cubense.</title>
            <authorList>
                <person name="Li C."/>
                <person name="Zuo C."/>
                <person name="Deng G."/>
                <person name="Kuang R."/>
                <person name="Yang Q."/>
                <person name="Hu C."/>
                <person name="Sheng O."/>
                <person name="Zhang S."/>
                <person name="Ma L."/>
                <person name="Wei Y."/>
                <person name="Yang J."/>
                <person name="Liu S."/>
                <person name="Biswas M.K."/>
                <person name="Viljoen A."/>
                <person name="Yi G."/>
            </authorList>
            <dbReference type="PubMed" id="23922960"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0070226"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2014" name="Appl. Microbiol. Biotechnol." volume="98" first="1749" last="1762">
            <title>Characterization of the fusaric acid gene cluster in Fusarium fujikuroi.</title>
            <authorList>
                <person name="Niehaus E.M."/>
                <person name="von Bargen K.W."/>
                <person name="Espino J.J."/>
                <person name="Pfannmueller A."/>
                <person name="Humpf H.U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="24389666"/>
            <dbReference type="DOI" id="10.1007/s00253-013-5453-1"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2016" name="Environ. Microbiol." volume="18" first="936" last="956">
            <title>Two separate key enzymes and two pathway-specific transcription factors are involved in fusaric acid biosynthesis in Fusarium fujikuroi.</title>
            <authorList>
                <person name="Studt L."/>
                <person name="Janevska S."/>
                <person name="Niehaus E.M."/>
                <person name="Burkhardt I."/>
                <person name="Arndt B."/>
                <person name="Sieber C.M."/>
                <person name="Humpf H.U."/>
                <person name="Dickschat J.S."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="26662839"/>
            <dbReference type="DOI" id="10.1111/1462-2920.13150"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="10 11">Homoserine O-acetyltransferase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:24389666, PubMed:26662839). L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism (PubMed:26662839). The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and linked to the NRPS-bound amino acid precursor by NAD(P)-dependent dehydrogenase FUB6 (PubMed:26662839). FUB1, FUB4, and the non-canonical NRPS Fub8 may form an enzyme complex (PubMed:26662839). Further processing of the NRPS-bound intermediate might be carried out by FUB6 and the sulfhydrylase FUB7, enabling a spontaneous electrocyclization to close the carbon backbone of fusaric acid (PubMed:26662839). Dihydrofusaric acid is likely to be released via reduction by the thioester reductase (TR) domain of FUB8 whereupon the final oxidation to fusaric acid may (also) be performed by the FMN-dependent dehydrogenase FUB9 (PubMed:26662839).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="10">Expressed under high amounts of nitrogen via regulation by AREB (PubMed:24389666). Moreover, components of the fungal-specific velvet complex VEL1 and LAE1 act also as positive regulators of expression (PubMed:24389666). Finally, the pH regulator PACC acts as activator of FUB expression after the pH shift to alkaline ambient conditions (PubMed:24389666).</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="3 4 5 6 7 8 9">Fusaric acid is phytotoxic to plants such as cotton and banana (PubMed:20955724, PubMed:23922960). It has been shown to induce programmed cell death in plants (PubMed:16868776, PubMed:23838885). In addition to a mild toxicity to animals, fusaric acid exhibits acanthamoebicidal, antioomycete, and antimycobacterial activities (PubMed:17927749, PubMed:21811925, PubMed:22864988).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="14"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUX2"/>
    <dbReference type="SMR" id="S0DUX2"/>
    <dbReference type="STRING" id="1279085.S0DUX2"/>
    <dbReference type="ESTHER" id="gibf5-fub5">
        <property type="family name" value="Homoserine_transacetylase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CCT65187">
        <property type="protein sequence ID" value="CCT65187"/>
        <property type="gene ID" value="FFUJ_02109"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02109"/>
    <dbReference type="HOGENOM" id="CLU_028760_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000437318" description="Homoserine O-acetyltransferase FUB5">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="77"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16868776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17927749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="20955724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="21811925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="22864988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="23838885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="23922960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="24389666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="26662839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="12">
        <source>
            <dbReference type="PubMed" id="24389666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="13"/>
    <evidence type="ECO:0000305" key="14">
        <source>
            <dbReference type="PubMed" id="26662839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT65187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="427" mass="47013" checksum="8E2A747E7D405A4F" modified="2013-09-18" version="1">MTTTTTAPALPTPIHDGLGNGTTYERSIPRPVNPFSNRVPGREIITVPNFTLESGVEMRNVPVAYMSWGKLSPKANNVMIICHALSGSADVSDWWGPLLGPGKAFDTDKFFVICMNSLGSPYGTASPVTAKNGDYSEGWYGADFPATTIRDDVRLHKLVLDRLGVRKVAAVIGGSMGGMHVLEWAFFGKDYVRCIVPAATSSHQSAWAIGWGEAQRHAIRSDVKYKNGRYGFDDPPILGLEAARMTALLTYRSRDSLERRFGRDTGNKKKAKNKGSETLPSNSTPIHSQGGADETPVAFDRADSNFAAQSYLRYQAKKFSDRFDSNCYIALTNKLDTHDLARGRTRTITEALSLIEQPTLVLGIRSDGLYTLAEQEQIARTVPNAKLREIVSDDGHDAFLIEWSQLNWLLVGFLHESLPDIMQRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV94</accession>
    <name>S0DV94_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_03422</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428477.1">
        <property type="nucleotide sequence ID" value="XM_023575268.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DV94"/>
    <dbReference type="GeneID" id="35396904"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03422"/>
    <dbReference type="HOGENOM" id="CLU_001266_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057211">
        <property type="entry name" value="DUF7889"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25417">
        <property type="entry name" value="DUF7889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="799"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="957"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1007"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1054"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1129"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1358"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1401"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1459"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="456"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="595"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="662"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT66396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1679" mass="185079" checksum="E9D3D8BBB04152B9" modified="2013-09-18" version="1">MEDPTSIAKAKSLHRTSTRSDDLLQPQDNPSICRICRGEGTPEEPLFYPCKCSGSIKYVHQDCLMEWLSHSQKKYCELCKTSFRFTKLYAPDMPQSLPVHIFIGHMARYFFQNVLVWLRGALAISVWLCWLPYFMRGIWSVMFWVSDEGFGSTSMMTRSNDTASSTASSLRGMSPSALDFETCPGSPLFVATTTPASVANTLLDGLSEQNISDFFARMMSIWGVAVKSDRLESTNATSSPSMSIPPTLLGEVAFLNNLTRNPTLNRAVISILEGQIITVLVIVCFILVILVRDYVVQQQPEMNVRPAFPAPENPVPQQEPMLVRPEEVDELQGPDESDDETLDTGDPFATANDVAFAAQVQADGRLRRRTNSELVVPPGLIETSPAEAGPVESQTPPDAVVAEERASVYEYLRIYRQADGDARKILELIHQEGLENKLSYWVDVTRRALHDEDDEPLLGIVTDPDTSRERAGSFGSTVASSSRKAYTPGSDDYPTPMDVPGESSSKGKEKEILPPLPHQTSETSFTTSPSRPRAVSDGPQLHDSVNPLANNSWSFVNLPVDTQEAGASSGLSDASQAALFGSENHEQLRHDAAASALPDLRENEDEPARQVERTGTFGTPEPHASEQPPLAAAQENGHPAGLVGRVTDFMWGDLDEQQRAVPDANAADPIAAQQDDTDGWETELDEVHQDVPPPDEAAAQEPEEPEDLGDGPGAGLDQEAMEDLEDFEGVMELIGMRGPVAGLFQNAIFCAVLVSVTIFACIFVPYNFGRVSLWVVANPMRLVRLIFEFSKLLQDAAVMVAGFGLWVAINMIDIFTGLIGGLVGSHVIIARKASWSLWTNAGSRVLDYTFMDLPMSAAEMQNFSAISHSALLAVKGNIGALFTITSKVVGFIFSGRIFTSSVSVESITSAAAVAWLKITALSSAVLKPNSWVVNLGEPDGPLNVNPELAHWSGLDRFWAIAAGYSTLFFFGALYLKRGSPFSRGHMLQAWEAGIIDTLHQASGIMKVIMIISIEMLVFPLYCGLLLDGALLPLFENTTFKSRLLFTYHYPLTSVFVHWFVGTGYMFHFALFVSMCRKIMRQGVLCKFSFIPCIAEANRFTDFIRDPDDPEFHPVRDVLERSLATQLRKILFSAFVYGALVIVCLGGVVWGLSYTVPGVLPVHYSSNEPVLEFPVDLLFYNFLMPLAVSFFKPGDGLHAMYTWWFRTCARGLRLTYFLFGERKIDEEGSLSLGNPVRGQQLPWYKTLFLELDIRYKVVPKTWTDFFDGGDAKPRAPLNNSEIRSLTRHKNHLKTANQLVESGRFVRAPASDRIKIPKGKRVFLDVDEHGRRIDGQEDTDLYASNQYQMVYIPPHFRARVFLFILFIWIFAAVTGVGFTIIPLVFGRRMFKMLIPQHIRTNDIYAFSIGVYLLGSAAYLVFHARSVWAKIKDRVSAARASLAAGNLEQRAAAVLLRGAKMLYAYSFLLVVFPLLISGLMELYLAIPLHTYMYPPTAASIQAAREGGPEASRHTVRVIQAWTLGLLYLKLGARMITSMFPDTRLAVAVRTVLRGGWANPDIGVLTRAFVLPGLAITGAAIFGPPALTSALIKYNIIPGIEAGESELAEAARIAITYRHSYPAIALAALLVKNTIGLVKVFNGWTARIRDEAYLIGERLHNFGAAAAGAGRVRGAWRAGGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVG1</accession>
    <name>S0DVG1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_03499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428546.1">
        <property type="nucleotide sequence ID" value="XM_023575354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVG1"/>
    <dbReference type="STRING" id="1279085.S0DVG1"/>
    <dbReference type="GeneID" id="35396981"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03499"/>
    <dbReference type="HOGENOM" id="CLU_036094_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT66465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="402" mass="44057" checksum="2CD6B291B7193757" modified="2013-09-18" version="1">MSRFCIPRLETLSKPKFLNGIPNNSIFAIATLIAVNALVWIAAGIVLHFHPRLISPAALSYVLGLRHALDADHIAAIDLMTRRLIASGQRPATVGTFFSLGHSTIVIVTCIVVAATSGALRERFDGFQHVGNIVGTSVSAAFLIILCIGNGWVLYKLIQRLQAILQERRDQVRLEGFVEEETQIQDHFALEGGGFLTRVFKRLFRVIDRPWKMYPLGVVFGLGFDTSSEIAILGIASIQAVQGTSIWLILIFPILFTAGMCMLDTTDGALMMALYTSKAFSRDVVAILYYSIVLTGITVVVSAFIGIVQVLSLIQNVADPQGRFWDGVSSIGDHFDIVGGSICGVFLIVGLGSIFVYKPWRRHVERQQQSLIQDPEPSLDAQSPAPSTEREDDGFVQAQRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVM1</accession>
    <name>S0DVM1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428685.1">
        <property type="nucleotide sequence ID" value="XM_023575515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVM1"/>
    <dbReference type="STRING" id="1279085.S0DVM1"/>
    <dbReference type="GeneID" id="35397127"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03646"/>
    <dbReference type="HOGENOM" id="CLU_070115_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="360" mass="39228" checksum="79A831778D889B49" modified="2013-09-18" version="1">MAGVAKEAVVPIEAVLFGISTLLVLARLALRTIRQHQSLTVSDWFLIASLLDAAALFGTDTAAYNLGGMDEYDPSAPPRSIEDQITLMKVSFAGNYFYDTGVYFPKLALLALYFKLIPQTLPLLRKFLYGVTALTGSFMLTTCFLDTFWCGANVSVNWELDGKCSTFDSKTVFRIDWVMNLISDMLVFALPFPLLFGLQLSRRYKAGLVAIFASGLITLGASIGRFATVEAIHAWTNVYVLSMTEIAAAIVVVSLPALKSLLHGLGLRSSKQNTTQTGSGYNKHSGTVTTSSHFNKLSSGRDHHSRELYASTARVAAGAEEDSGSEVELTNLQGIYKSARISVTYQRREDGDWQGNSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVP7</accession>
    <name>S0DVP7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428616.1">
        <property type="nucleotide sequence ID" value="XM_023575434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVP7"/>
    <dbReference type="GeneID" id="35397054"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03572"/>
    <dbReference type="HOGENOM" id="CLU_114609_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484581" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29375" checksum="CAF6EB74804DF00F" modified="2013-09-18" version="1">MEISRLILGIVVLAWRTPALSTANINETRPFEQLFLDISIGTVLDLNNSLQLVEPWASEYVSSIREARFGDALWARYHMFGTIVDGLVEGSNQTVMEALEESAMEYKATVPDDYRHALSVYANTSNNDKHRDVLDLLSAVHLRDVSHLKERATFGIKCDIGHNEAYRYNCLRLIELMSTSRAYIGAHDRTIFRYGNCHLRVGTLTHAPDVTYWTAHSVAELIEGHCTRECCNHQLKTSGYSPANRSHRKVCLSSKVWGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DW46</accession>
    <name>S0DW46_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428807.1">
        <property type="nucleotide sequence ID" value="XM_023574997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DW46"/>
    <dbReference type="STRING" id="1279085.S0DW46"/>
    <dbReference type="GeneID" id="35396661"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03179"/>
    <dbReference type="HOGENOM" id="CLU_140539_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="122" mass="14233" checksum="0951CF0D9B07A656" modified="2013-09-18" version="1">MCKHILNAQVSVRSPCCRKWFDCVECHSEQESHPLKESFEMIFACKKCRKCFRKDVKEFEEADEFCPHCDNHFVIDAKTPQAALSIESDDVRMDNKMLKDDRQKTKGLRSIFDPTEEADKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWB1</accession>
    <name>S0DWB1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428925.1">
        <property type="nucleotide sequence ID" value="XM_023575645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWB1"/>
    <dbReference type="GeneID" id="35406466"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13010"/>
    <dbReference type="HOGENOM" id="CLU_057711_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484987" evidence="2">
        <location>
            <begin position="30"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="363" mass="39650" checksum="D9976477F98CD5F9" modified="2013-09-18" version="1">MASALVKPGILNLTLFIAAILSFIPPTTALQRSNKQFREFFPAWEPLLKDQLKYNCSSEIQEYLNISSPALRPGYRVINCILTTMPEFRKAELASAAVILGLAPSVLQLLSASYLDTAILAYRRPGLALLLAMCSSGVKPLTASEYDDFIAKMGAESSTTFGVPRFVGAQAIVSWAEYIIAAASVANNAYLTYQLCLQAVCTFAPAEDFLPAIWTASALAIHLFGYITARLKITVDTKSAWEDRGKLWSEVTPTAWQPKLHVKANERHAGWFLTLASALYVGDCLQALFGTLILSSLVFISVRDSAIIVIRLIGSALFARLILIYELAGLKTDGEGYPASGSTIYLESLEQNERSLRGSRVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWD4</accession>
    <name>S0DWD4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to purine utilization positive regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_03495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428861.1">
        <property type="nucleotide sequence ID" value="XM_023575349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWD4"/>
    <dbReference type="STRING" id="1279085.S0DWD4"/>
    <dbReference type="GeneID" id="35396977"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03495"/>
    <dbReference type="HOGENOM" id="CLU_012331_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT66780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="707" mass="78913" checksum="2DB83C7FD437A2D8" modified="2013-09-18" version="1">MPGARNSNGKRPHQASLPDRSAPRTRMACSRCQRLKRKCNLELPTCSNCRSAGAECVDGKSSRADAAPRQYIASLTNRINWLESIIRSNCPDVDLSQGPPVNIGESWNDTSSEVTDNSALPAPEPVQQSSEIAQNSENEPPVTQPATQPITSTSEPTGASAMTHEIGLVSLATNQDPRYIGPSSGYFLARVLLDSASKSDDSVGRANRNAPFPIRLVEALQGPLPLPPRDTAMQLFYDYLDMAYDEESQDPAAHFQVFMVLAIGSAVLSARTRARIPAESYCLSALQYLDELNVENSLKGIQCLVLLLIFTIHSPCVRLNVWYLNYHCIAALVDQGLQRNISMGPDYSLLNQEMRARIFWVIYSFDRIIATMMGRPIGLRDEGLTRKMPFGLSDEQLVNQRQQQTAEPSSEMAFAVHLFEAAKLNSEIKYIAQSIIRETPRYAYPRVTDINDWQNAMLQRLDEWSNKIPGLGNPDVLYLRTTCQLRYHGLRMLLLRPSPAIPKPPKDALIKCHQSARESLQLFDLLYKKNLLVHNWTTFHGLVLSSITLLYCIQSVSEIARSTGVDAFMSDLSISLSILGATGEHWSGAKHSRDILDNLGKSTVRYIREKNRRSEGLRDRSAPQVNGQVIDPTLSTDAWESLGQEFNSIQGSSSQLNIDDDMGFMQNQFYEGLLNETFAEYFEPTESTNLDNIVRDLFQGLIPTDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWN2</accession>
    <name>S0DWN2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_03840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426979.1">
        <property type="nucleotide sequence ID" value="XM_023572943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWN2"/>
    <dbReference type="STRING" id="1279085.S0DWN2"/>
    <dbReference type="GeneID" id="35397321"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03840"/>
    <dbReference type="HOGENOM" id="CLU_113403_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT64898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="155" mass="17938" checksum="E9ED9E56A9D2E87D" modified="2013-09-18" version="1">MAVQNPPVPEEKLGVPSRNPLPLSASQEAQVRDIFYQKIMNTTNNPPAFAACALGRTFTVSFACRAEHRSMNSCMKLHATQSAHDEAREEWFALRIERQRERERKARVAQAQEEFMREWWGLPEHVRLSRQKEMEQRGERVHGLTAKDRPRGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWQ2</accession>
    <name>S0DWQ2_GIBF5</name>
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        <submittedName>
            <fullName evidence="7">Related to HNM1-Choline permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCT64918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWQ2"/>
    <dbReference type="GeneID" id="35397299"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03818"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="41"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="67"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="130"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="159"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="190"/>
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            <end position="400"/>
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            <end position="447"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="513" mass="55886" checksum="CC63C2F0050DAEC9" modified="2013-09-18" version="1">MTSSTQEGALQQRLSTLTMVAMAFAILNTWIALAGTMAYILPSGGSVSFIYGFIVCVLCNLALAASLGEMAALWPTAGGQYHFMYALCTPKWKRSMSFFVGWTNIAGWLTIVTTQAFFAAQLISAAAVVASNNAYEATQWKTYLFFLAILTFGTVGNVWGNKILGRWNDMALYWSVLSVVIMSIILLSMSPKTDARQVFTEFRNETGWSDGVAWILGLLQSALSLIGFDVVLHLTEEMPNPSRDAPRAMMLAIVIGGVTGFLFILVILFCLTDPETILASNTGMPIVELFLQSTKSRAAATILALMLSVCFINGTSASITSASRLLYAMARDKGIICHNYFAHIEPKLDVPVRTITLCFIFNVLFGLLYLGPAVAFSAYIASCTIFLNVSYVGPVIALLVRGRGILKEYQTRKTPARMGLRTGAVVNGIASVFVVVITIFFCFPTALPVSANTMNYVSAVVGVFYVLLALYWMIYGKTFEGPNFEAIIGQPLQIKGEHETEAVQEKSETSTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWS1</accession>
    <name>S0DWS1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427019.1">
        <property type="nucleotide sequence ID" value="XM_023572993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWS1"/>
    <dbReference type="GeneID" id="35397276"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03795"/>
    <dbReference type="HOGENOM" id="CLU_2498043_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT64938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="86" mass="9407" checksum="0D8A1C404A0848E4" modified="2013-09-18" version="1">MDGLPQVRPQVDNGTIVHIGTKWLFNFFRYYNAERLDTEIPAGSPIGRGLCDNNHIDGGDPSDRLGSIPYIGKYGYERGPGIVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWX8</accession>
    <name>S0DWX8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427993.1">
        <property type="nucleotide sequence ID" value="XM_023574681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWX8"/>
    <dbReference type="STRING" id="1279085.S0DWX8"/>
    <dbReference type="GeneID" id="35396378"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02896"/>
    <dbReference type="HOGENOM" id="CLU_022039_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="592" mass="64780" checksum="4387440DA7B99ABD" modified="2013-09-18" version="1">MPRAKRARRAPARSAKSHARSPSPDASDNQVPRPTQSPERGRRRTTRSSGAYSSAVNEQDVLAANRRRDAALDKLANEDPTSTASKNVGDGDSGSSIEGGRRVTATPTRRRDTTGLDLADSVFGDLDDSFGLEDDDTRPGLRSADASSLNLSNFRRRPRQSSIIGRNDPPIRPSSRGGNTPSISSTLHFGAFKRRAREPSILGTARKPRPEENAAGQEPDSASEDEDEDDFVPEAESTPLNNRRRTKPETELEIEVPASPEVSAGPKHRKRKSEDTLPSSGRPDKISRIERDAGEESEEEAGPAPQVISDDASDSSLSDLDSPLGPSPVLLDRPVTPINNEELMALPASSDSEDVNWPDIHTLAKRRRRPSATTPIRADNFSDVSSPPSLTHSPNYAEASKSRGRATTRRQQPSPKITTADLTSLLPKRHYKKQRDPLGLESDEEHDTSGIGEDEDELSYLDGRAARRRRGGRSTSRGGARRPGSRGGRPTQALKPRQPTSDRQTGRNAQTYSRRSSDKENENDAGSDEDEDEHEASRFQPLPDDTFENGSGENASTPSADELKQAARKFKEVDRWELDFEEVTQSSSPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX27</accession>
    <name>S0DX27_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427109.1">
        <property type="nucleotide sequence ID" value="XM_023571455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX27"/>
    <dbReference type="GeneID" id="35408259"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14889"/>
    <dbReference type="HOGENOM" id="CLU_049343_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF38">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="308" mass="33431" checksum="1344EA1C5A017836" modified="2013-09-18" version="1">MSFDLKGLVPAPVTPFTKDGKVDYDAIQRLGSWLGSIDGVKGLVVLGHAGEGTFLTQQEQVDTIKAFVKSVDNKIPIIAGITGEGTEVAALEAKRAKEAGAQAGLLYPSHGWLRFGYQPGAPQDRYKVVYEVSKLPLILFQYPDNTKATYNLQTLLGIAAQPGVIAMKNGVRNMRRWDTEIPVFRRERPNVPVLTCHDEYLLHTAFDVDGMLVGYGGIAPEPLLELIKAGKAKDYAKAREIHDLLLPVTKAVYHRGSHMEGTVALKHALVARGILSHATVRSPLLPLPDGAEEEIHAAISSATLKKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXL0</accession>
    <name>S0DXL0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_13511</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429390.1">
        <property type="nucleotide sequence ID" value="XM_023576204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXL0"/>
    <dbReference type="STRING" id="1279085.S0DXL0"/>
    <dbReference type="GeneID" id="35406965"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13511"/>
    <dbReference type="HOGENOM" id="CLU_012173_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM20" evidence="13">
        <location>
            <begin position="559"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="528"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT67309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="666" mass="71473" checksum="35043B5AEF07710D" modified="2013-09-18" version="1">MDLVDVGDPVSSVSINSTASLIQPIMYFVSSAFLLGSFALQSVLGRPAFDERSLVQERQSSVDSFIKSESSVAIEQLLCNIGSDGCNSKNVATGIVIASPDTQDPDYFYTWTRDAALVFKYVVDRFINQYDAGLQRKIQEYIASQAKLQGVSNPSGSLSDGSGLGEAKFNVDMSAFTGGWGRPQRDGPALRATAMITYANWLIANGYTSTANDIVWPVVRNDLNYVAQYWNQTGFDLWEEVKGSSFFTTGSQYRALIEGAALAKKLGKSGDNYSNIAPQALCFLQTYWISSGKYVDSNINVNDGRTGKDANSILSSIHNFDPALNCDPATFQPCSDKALANHKAVTDSFRSWNINKGISQGSAVAVGRYVEDVYYNGNPWYLATLAAAEQLYDAIYVWKQQGSITVSDVSLSFFKDLVSSISTGTYASDSATFKSITDAVSKYADGYVAIVAKYVGTDGHLAEQFDKNDGHPLSATDLTWSYAAFLSAADRRAGVIPPSWAGSVAAVPNQCGTNTVAGSYSSATATSFPASQTPKGGVPTPTGTQTSTSTSSSSTSTSCPTATSVAVTFEEFVTTNFGDTIKIVGNIAALGNWDTSKAVALSASDYTSSNPVWKTTISLTAGQSIQYKYINIKKDGSITWEKDPNRTYTVPKTCATKATQSDKWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXY5</accession>
    <name>S0DXY5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT65323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427404.1">
        <property type="nucleotide sequence ID" value="XM_023573967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXY5"/>
    <dbReference type="STRING" id="1279085.S0DXY5"/>
    <dbReference type="GeneID" id="35395740"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02258"/>
    <dbReference type="HOGENOM" id="CLU_037990_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28357" checksum="6A796D1EC2ECF744" modified="2013-09-18" version="1">MGDKIHSISDEAKALGEKNKEHFDQVAADVFKHPWIQRLCSQISDELQQNLGWIGVPDKPGQFKMLDYACGNGVASRALAPYVSVVRGIDISSKMVEQYNMLAEAAGFSSDKMRAIHGDLMDPEASPSPELDTPEFNDFDLIVMCMALHHVQDYTAMIQKLSEKLRSGGVLLIIDLVASSESGCPEAPLSKELSNHTMSKMGFTEVEVKTAFEKAGLEGWSWRWCSERSQVPEEIGGEQQGFFARGCKSAGIGVVKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYQ0</accession>
    <name>S0DYQ0_GIBF5</name>
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        <submittedName>
            <fullName evidence="5">Related to Gbp2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_13635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT67540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="S0DYQ0"/>
    <dbReference type="STRING" id="1279085.S0DYQ0"/>
    <dbReference type="GeneID" id="35407089"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13635"/>
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    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000232">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="103"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="227"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="390"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="490" mass="52312" checksum="6A423F347A0B1AA0" modified="2013-09-18" version="1">MEPQLVLLPTNKLKRERSRSPRRRSRSPDRSHRRRSYSPRSRSGSRDEYRRNRDRSPMTSTGAPGGGQSAGYGGQAPHRSYEERAVAREQMMNNIRETSQQDRRVYVGNLSYDVKWHHLKDFMRQAGEVLFADVLLLPNGMSKGCGIVEYATREQAQAAVATLSNQNLMGRLVYVREDREAEPRFIGATGGNRGGFGGGGQGGGMPGGFNPGYGGGAPGGGAGGGGRQIYVANLPFNVGWQDLKDLFRQAARNGAVIRADVHIGPDGRPKGSGIVVFESPDDARNAIQQFNGYDWQGRVIEVREDRYAGSGPGMGFGGRGGYGGGMRGGFGGGFGGRGGFGGGRGGFGGGFGRGGFGGGAPGGPGFEPPASSVPPNPFTDFATAGTERGEIIYVRNLPWSTSNDDLVELFTTIGKVEQAEIQYEPSGRSRGTGVVRFDSAETAETAIAKFQGYQYGGRPLNLSFVKYLNQGGNDVMDTDPHGGLTQDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYV4</accession>
    <name>S0DYV4_GIBF5</name>
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        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427719.1">
        <property type="nucleotide sequence ID" value="XM_023574346.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DYV4"/>
    <dbReference type="GeneID" id="35396078"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02596"/>
    <dbReference type="HOGENOM" id="CLU_241636_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="700"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1538"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1538"/>
            <end position="1549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1599" mass="177717" checksum="026213228D69E1F2" modified="2013-09-18" version="1">MVRTRKEENQPTTNTPRTSSVRKSKRKRKGQAQNSEPELVQPSPARKRRKLGKKKEWWNIRRVIDEEYLADPKSGEINHRCFVEWETDSDGETYENEWIPYEDLNAEALEDWEKEKENRELESTEREAQRRETRNRRGLRDLTPRQGKSETPVDCNKQQQPKLDASTPDISRFDSHEQDVQPNRSFRIKSEEPVPSFISASSVDAESVSSFELSRAPTQGVVVLLSKPDNFDPAEYQSVTTQNSSQRITDLEDDDQRVTFASQLSQETIPDSQDLSGNWDYQDRESQPAARPDFVPRSPEISENPSSSLVEDNPGSNRQVREVVCQKEVHNRESIVRSPEREAFQSANAPVDLKTEYPDSENPEDNLSPTDFGGFTGAVYQDDQTEDIHNLEETHDLEGENTENRADTNNQIFDGDNLGSTGGIRDTLSPENESFETANSQASHSSNSRDLPVNQDPYGQDSVSVNQGSGDGQRVVQDHVLDSSSRLPFEEETLGSREPGVERSAPTHHHPQSDRNERGGLQSEKGEVNPQRPDKPNSVSGVEDLSQSQALSSSSKWIDTIVPDSQGDSSLSTDLNIITGRTSTLVSKAEVTPLASPTQIVPDSAATGSEIIPSRQPGDSHPATSEGGIHLDSSLPSDQSIRHVVGETAASPRSSPGSQRTQKPQTYYSQPQGSYGSLDISSFLSSAAGTLNKTARPRATIETQASQEKSFEASQLSKPEPEKNIVSDQRIGSSQRPPSPTTTTQINRDSEGLEKSQLTSKQKMERPGSQTRDSAVDELKSYINFDRDLALTHVGDSLEENLDGTPYEVIADEEPIPVASASSQAAVLQSQPVYSMDPWKAQAIGTNSDTPVSSIAPAAIMADPSTSAVARMREELSRRFAESDISLTHSIISQDEEDNLLPATISPTVISIVNEPVASTHTLNFPNHGSVPTEAESSGHSITTAQVPVDQVSDVLSESSEQNDFYVQTKVTLPMQASRRSYYGEVIEDHKDEIQAFSRCFTGETQEEPSEELTKKIKNLFERLFEICDYPQDVIGSVLETLPSSELARYCCDANPKFSFLFELMDALDRKEKEILIVVGTKELVRLLFKLAEAAKVECSAESINRHTKFASFARISIALTSEDFDPFSFDVIIGYDYRYPSSLIARQLCDNPARKPPLVLRLVTTYSIEHVYNTLQGATLLETQNAILASTVSASRYLEEPERGYCEPHEVAEIFANYFNGNTDTLNWEPQGIPDDVLDIFENPGTQTQLPFTGDALYGNDLKRKHTNDEGDGDAKRMRTLPLRDPPTDTNNPPMPIAVRQMLESATPRSESRDRKAMISVPLGTLETIQEQIDEYKRQTVQAGEVEEELKSHINRLDKELKDHRKTLSKIESSNRAALQDRTVAERERLRTEGVAAAAAKVAQKEKEKQQQRIDELESVIARLNQNPETAKREEALSEVKGQLQLSESRRTSALNDVDFMKSRYQDVDAQALRLANENKALKIQNEELEQKASENLRAIHAQNVAMERQELLGQIAGLQAQLQQRDAELYNANQRLASVSNGRNTRGGSMPRSPRVPSGMSPRPRAAFSASRGTSPIGSGQPFVGQQAGNGRWNHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZV6</accession>
    <name>S0DZV6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_13110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429018.1">
        <property type="nucleotide sequence ID" value="XM_023575756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZV6"/>
    <dbReference type="GeneID" id="35406565"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13110"/>
    <dbReference type="HOGENOM" id="CLU_040943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="518" mass="59466" checksum="B35C28CB055AF971" modified="2013-09-18" version="1">METSGEQQRPNEARPASVPQPVLIPRLPLDILYHIGYLLAAESVVEHEHQIDSNSSCDCCMDKSSTTLYKLTYTSKATRDVLEPLLYRNLILTTPQDVTNIFINLIQRPELRQHVQYILCYADLAGPRVRKFEMPECKKIWSKRCPSDKPALMRLLDGAGLHKLAWSACMLERTKQRFMFSPDFKHDGILELLFASILFLSPNVTSFTWRDCNNNPKAFILDHIMCKAVHDGLPLMPKLQKLSTEKAEFEESKQAQFFTPHINLWENLYSLQLNDIDLDMEFVLMLFNGSFKENRPVRELIVRCVTGSERPESLTSFPPGFELASTMLLGDKNLDNYKDHFKAFPNLNLLDVTFVFHRGRMEEGSLTLKAFLHAVGSPERLCLSGHPLPTSTLDTGVTHSRLKYLKVREFQPNAPAKTTSKDNLIAGLNQFWNKKSMIVPNLKEIDWDHYTFKREDMEGEDKAVWELVGEEEWEDDSGSDEDEDEDEAALWYSMGRGDIDAFVENAMDVEDMWDAWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E041</accession>
    <name>S0E041_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430251.1">
        <property type="nucleotide sequence ID" value="XM_023577135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E041"/>
    <dbReference type="GeneID" id="35400415"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06938"/>
    <dbReference type="HOGENOM" id="CLU_095749_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="247" mass="28133" checksum="81362CF359F8A604" modified="2013-09-18" version="1">MPSIFGNVRCDGCQAMIEDTETSAVLFYCYNYPTGDWGHQILGRSSRLTIIQNTRYTFLHRRCFDIFQIMPTGQQRSQAEINCFRGAIGWRKLDFMRIFPEGLDIPGLPRVSLIAVARAATFALQNPLVRELSYIEELLNIVRSYCPDAYFWNMVQLMGLKGFASTGNPVMEDLSRVESWKRLQPAPVCGRPLEDPDGLLISLDSDGICEIQRLGSHPHPPNHDPQVKLRKYVLANEKDLESVKAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0D2</accession>
    <name>S0E0D2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430346.1">
        <property type="nucleotide sequence ID" value="XM_023577246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0D2"/>
    <dbReference type="GeneID" id="35400515"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07038"/>
    <dbReference type="HOGENOM" id="CLU_2049835_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="121" mass="13544" checksum="1BC6FF5873D5E1EE" modified="2013-09-18" version="1">MSLSKQDMKYFANGKVITEEALIAIAAAKRDDFEKWCGTRQFQHFLMRARLGSLSGPMTLPRLQNWAADEMFHLRSLEESQTHTGGNLVQGTTSKVPTKEKNMADVEEGPHFVGDDLIAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0P7</accession>
    <name>S0E0P7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430514.1">
        <property type="nucleotide sequence ID" value="XM_023577442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0P7"/>
    <dbReference type="STRING" id="1279085.S0E0P7"/>
    <dbReference type="GeneID" id="35400692"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07215"/>
    <dbReference type="HOGENOM" id="CLU_045013_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="128"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="395" mass="43381" checksum="3D56D49034D3F13D" modified="2013-09-18" version="1">MSGQTPAWKKLGLKLKQPSDASEPSFGHPTSSSTSTSIQSGTKRKFDAPPPSNSSQVAKRPRQDEATTSWNAPGQLKRQKSVTFADSPSNNHSTRTPSRPIKQSKAKSKGPAKKPQPQVPTDLKPALEYLRLWKTARDSWKFNKNHQSNLIKHVFDADGIPASDIETFYDYIQDLKGFVRMRLLENAREVRDQDQSDGAKVFPEGTKDLEATQKRYEEVLAKILENHPVGTKRKGFTEVDYLSDSEEEDVIIRRLVKRMRAELVIDELSDGEDTVASIASSQTITASDNNVTSTPDAEKTVKITDGVAGKRRRKLRVNVEDSDSSSSESDSDSDSDSDSDTSSSGSSSSSEDESENEAPARAYRQPGEEDSSDSSSSSDESSSDNSSSEDESDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E168</accession>
    <name>S0E168_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428514.1">
        <property type="nucleotide sequence ID" value="XM_023575312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E168"/>
    <dbReference type="STRING" id="1279085.S0E168"/>
    <dbReference type="GeneID" id="35396944"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03462"/>
    <dbReference type="HOGENOM" id="CLU_658964_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="417" mass="48112" checksum="922F58020B2F87D4" modified="2013-09-18" version="1">MFPHRDFLGIEKDQFWWNPRPHDVPRWKHIMRFDTNGFENYQKGLDRFGFSCSDDESDAESHNGSSTNSGNKSSAENDSDDGSSDEPEEKDPEEVENMFYTLEFYPLGLMSYDDFLNFEKLMEYRPSPPDISHVRSILFQKGLPIEITDRILERIAQPLLYRTIAIEGRNGAKSIGTLLLRTFVENPQLAEQVRAVSLTDCIKLSEQVEILDRDATKTLVRSAMEKLDVPPALKRMMMRKIAYSDFAALILAYMPHLQVVDCTIGVRTFILPWLLSASPDAGRPLGWLKRDRKVEVSDAEDNDKKQEENDFSDDEYYVAKKEVSMEEYQQKGISKGTFANYRFANLIEIRIRAVEYPGAIEGAWTIEPLLLNSKLKILRTFGTAWYGDELTNFVWPEHKTTTWSISTLWNHMSMPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E170</accession>
    <name>S0E170_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable LST8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_07210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430510.1">
        <property type="nucleotide sequence ID" value="XM_023577436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E170"/>
    <dbReference type="STRING" id="1279085.S0E170"/>
    <dbReference type="GeneID" id="35400687"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07210"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000339">
        <property type="entry name" value="WD-repeat protein pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT68430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="317" mass="35375" checksum="243C266414A9756E" modified="2013-09-18" version="1">MSVILCTAGYDHTIRFWEALSGICSRTIQHPDSQVNRLCISPDKRYLAAAGHHTVKLYDIKSTNPNPLLTFEGHTGNITGVAFHCEGKWMVTSSEDGTVKIWETRTGSIQRSYNHGCPANDVVIHPNQGEIISCDRSGSVRVWDLAENNCSHELIPEEDVSVSSVTVASDGSLLCAANNAGNVFVWNLIQSFDRTQLVPVTHFNAHKEYITRILLSPDVKKLATCSADHTAKIWEVKNIEPSTDLEPKPYPLEATLTGHQRWVWDCAFSADSAYLVTACSDHYARLWELHSQQIIRQYNGHHRGAVCVALNDYSETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2F7</accession>
    <name>S0E2F7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to Mitochondrial import protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428939.1">
        <property type="nucleotide sequence ID" value="XM_023575663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2F7"/>
    <dbReference type="STRING" id="1279085.S0E2F7"/>
    <dbReference type="GeneID" id="35406482"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13026"/>
    <dbReference type="HOGENOM" id="CLU_127808_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="123" mass="13426" checksum="D2AADF3FACB07C2F" modified="2013-09-18" version="1">MSDEHNHLAESGVTLHSDSELYSAGDDLSSPPSSNSPVILYKPPTVWSLIRGAAINLLLPFVNGMMLGFGELFAHEAAFRLGWGGTKVFPLSRRRVHPIGPGIELREKPYAPRPSLDDFASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2Q4</accession>
    <name>S0E2Q4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_13139</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429044.1">
        <property type="nucleotide sequence ID" value="XM_023575788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2Q4"/>
    <dbReference type="STRING" id="1279085.S0E2Q4"/>
    <dbReference type="GeneID" id="35406593"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13139"/>
    <dbReference type="HOGENOM" id="CLU_037229_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="12">
        <location>
            <begin position="102"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="13">
        <location>
            <begin position="212"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT66963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="414" mass="45729" checksum="0EE0A2CA3914F944" modified="2013-09-18" version="1">MDEEAEIAHSIAIPELTQSPQANHTSSATANENTDTNTIINNPNAGTVVTRIEDILAQIISALAAGHELSIPFSARRSTRRAANAQPEQVHFPGRNQQEAVKFARILLILQLSHDALVSGTVLTKRHIFYQHQHLFEKQGQVDDLVDDIAFNLGISRGDLNIVAASKGALAGPLLIRFHDGSTLNPCSGDLGVAIPTVQSISSIDVQNIKWILVVEKDAVFRSLCSSQFWRNCIFGPGVLVTAKGYPDLTTRSFLNFVHTQYPQLPLLGLFDYDPDGVKILRCYRYGSERLSHEADLGIEALRWLGIRSVHLSRGHTDTSLSNYGQPSHVSITSIQCRNPVTYLNGRERAVAISTFKKISLRSQNELEGSELRLELQLMTMLGVKTEIEWLDESGDLCSWLDGEIGEALISERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3D9</accession>
    <name>S0E3D9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bys1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431265.1">
        <property type="nucleotide sequence ID" value="XM_023578459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3D9"/>
    <dbReference type="GeneID" id="35407774"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14322"/>
    <dbReference type="HOGENOM" id="CLU_144311_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495482" description="Bys1 protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16275" checksum="4C3B91B8AA7900D9" modified="2013-09-18" version="1">MKFSILTALTAIVGSAAAANQAVVKNDCSGTIYVQSWPYNGGAPGPLVALKPGKTFSENLRSTGSTVKIATTKTLSNPLFFGYSSTSKPNYVYYEFSTQWGNPFANKHNILTTGKGCKQFDCAAGDASCYSTPSMKKVYGCPQPATITATICAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3E2</accession>
    <name>S0E3E2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Probable bifunctional purine biosynthetic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_07897</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431401.1">
        <property type="nucleotide sequence ID" value="XM_023578201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3E2"/>
    <dbReference type="STRING" id="1279085.S0E3E2"/>
    <dbReference type="GeneID" id="35401374"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07897"/>
    <dbReference type="HOGENOM" id="CLU_005361_2_2_1"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000007">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="113"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT69321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="797" mass="84749" checksum="632B5386851DFF8B" modified="2013-09-18" version="1">MADLRILLIGNGGREHALAWKLSQSPRVEQIFAVPGNGGTAGCPKTSNVSSVKAEDFAGLVKFSQENGVNLVVPGPEAPLVDGVEGWFRKAGIPCFGPSKEAARLEGSKTYSKDFMKKYNVPTATYENFSDYNKAVAYIDSVDHDVVIKATGLAAGKGVILPQTKEEAKAALKQIMVDKEFGDAGDEVVIEELLIGDELSVLTFCDGYAIRSLPLAQDHKRIFDGDQGPNTGGMGCYAPTNIATKELTELIDREILEPTISGMRREQQPFRGVLFTGLMITSKGPKVLEYNVRFGDPETQTVLPLLSADTDLAEIMLACANGYLDNCKLTIENKFSATVVLASGGYPGFYPKGKAMSVQTPPAGCNIFHAGTILDSTGLKTSGGRVIAINAVGDSLRAAVDAAYAALDKKVIDFEGAFYRKDIAHRAFRSTAQTSMTYAQAGVDIQAGNDFVEKIKKAVASTKRPGADAEIGGFGGEVDLSQAGYPQAPIIVGAIDGVGTKLMIAQAMKKHDTVGIDLVAMNVNDLVVQGATPVMFLDYYGCSKLDLSTAADFVQGVADGCRQAGCALVGGETAEMPGMYQNDDYDAAGCAVGTVTADIKLPRKDDMAQDDVLLGLGSAGVHSNGFSLARRIVSRAGLSYTDPAPWDQSTTVGESLLTPTRIYVKSLLPVLSHIKGLAHITGGGLVENVPRMIPESLAAEIEFGSWEIPPVFKWMREAGNVEPIEMCRTFNSGVGMVIAVDPAKADSVSQALTDAGEKVYRIGRLTRRDQGEACLIHNVDSWKADTAVPSKRKDIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E401</accession>
    <name>S0E401_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to GPI-anchor biosynthesis protein PIG-F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_07182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430482.1">
        <property type="nucleotide sequence ID" value="XM_023577405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E401"/>
    <dbReference type="STRING" id="1279085.S0E401"/>
    <dbReference type="GeneID" id="35400659"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07182"/>
    <dbReference type="HOGENOM" id="CLU_069429_1_0_1"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT68402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="249" mass="26359" checksum="8940397A78572E53" modified="2013-09-18" version="1">MSTTLVKSGTLAQQPAPKAAVPAIPLVNSPAALPASVAHQLLLAGLFYWRFDALVADPVSTLQTGLPVVAAIQAVYLILSLPPAGSSGSSKKPRPGEKKKSDGREAKAIPTAVISLLLALILTPALHLLLVLFGAPFLTHVPHTFLCCAHIAVLAIYPVFYVRGSDPVPLQAVVGVSAPFDQTFGGFVGTVVGAWLGAVPIPLDWDREWQKWPVTIVVGAYIGYIVGSQILGTVFFGKRWEVTPEVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4F9</accession>
    <name>S0E4F9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431711.1">
        <property type="nucleotide sequence ID" value="XM_023578753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4F9"/>
    <dbReference type="GeneID" id="35399011"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05532"/>
    <dbReference type="HOGENOM" id="CLU_321596_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="785"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="563"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="901" mass="96410" checksum="EDDA67CA37F1A49A" modified="2013-09-18" version="1">MSSDLVQSTLGGGESYISPTTNLQPDSPEYGKVEAMMGRIMDFMCQQFRNMNDRLSELKIEVGEISGSKTMLALDLINERLSHFDDINARFNEAGMLDHGNIRALDVFNGRLFSIEEDIKCLKHAIQGTADDSDDSIKRYLGKIDDRLSNLESNLHRLEDRMFANLDGAIDDETGFITVVMDALDFQKLDAMNPTEIAQKLREKGSGWKIESIKLKAPKTADQQHQVIINFLTRESEAYMRQHISEMSELFGLEHGVYCLSPVYTLHVEHLVPHLSKGGMGHKELEEALLKALGVKDIKAKVTYERMLLKTQDFELVSRLCFTGVNLLGHYYEIVPFCVQGTPLFCYRCWKTGHFKDDCTVSVMLCGRCSGAHDTRGCKAASRCCNCNGPHVTWSPECTISLSREEHRASAWYRQLVPHWAKHLPKTGKPILPTVTKTKPEKAKANPAESSPTKSGEHSGASPSKAVEKRPVGRPKALPSKESGQRTLGQFLKTGGIGSSPATSKKPPSSPDADMTGTNTVPLPRSEGTGVPSPNTQPLTANASSSSVSDVDNSLTAMEMDTDTTSSSTPGASQSSGSDGDSGAADIDIDTASTADNEPAESEAPGAEQSKPSSSTQAKSDPKGGIQGSSKNNNKNNNNSKKTNKNNNKNKNNSAPKQTTTQTITSLVSNTSQQENGNKPGGARGKKKPFSWREHKAKKKAQKQADKSASAKNTPAPVSDAPVSNTPTSEAPGVPSSPAPLRTTPLDSGIISTPIPPAGATSAPATPLPVVPVPAMSVPDASVAATSAPAPLPPIPTSSTPCNSVPTASLPSTTNGPSAPMFPTFSNLLPLPPVVGITQPSGFNFEEISQPVSPSGKREGPLSVHSPEKRRKPSRSIESGDEAMAALNSVVQDENVARAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E510</accession>
    <name>S0E510_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429789.1">
        <property type="nucleotide sequence ID" value="XM_023576662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E510"/>
    <dbReference type="GeneID" id="35408079"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14699"/>
    <dbReference type="HOGENOM" id="CLU_072365_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36423" checksum="2DB2F7C99B396F9D" modified="2013-09-18" version="1">MSQYAATARNLSRAPLAGKAFSPALPTLGKAAPPYQSKWKRTAPVPLSGENFLDVLFNRTPVIKQPGFLGREECFAHEKALSHRIAPYRYYTGPLLQRVGCAQFEYQAQAAADFENRKNEKEEYFKVAQSLSGLHQEVADQTGVNAWEKVIGTLRALLPEYEIVRASEGPGKTYFSGNFRALNDSTCLHCDWTPYDAATEDWIINQVTHQAVFNLYMAPVKGGRTWVHDVEWSEECLNFRDPDTYGYRDEIIHGRQSVVVKPEVGDLWFFNSRNMHQVEKVEPELCPELGLPYRPRLCLSSFIGLLPEHKTGGRPRLILWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0E546</accession>
    <name>S0E546_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to GDP/GTP exchange factor Rom2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_05929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432078.1">
        <property type="nucleotide sequence ID" value="XM_023579196.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E546"/>
    <dbReference type="GeneID" id="35399407"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05929"/>
    <dbReference type="HOGENOM" id="CLU_001083_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057283">
        <property type="entry name" value="RGF3_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23582">
        <property type="entry name" value="WHD_RGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="890"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="1346"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="541"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1202"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1654"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1202"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1223"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1657"/>
            <end position="1678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1712" mass="189977" checksum="5D621B15D830D5D8" modified="2013-09-18" version="1">MSFRGDDQRRYGHVPPVQYPVAGRGQEYQQQQQQQQQQQPHSSYDDIGRRASFNGGDDAAYIQPPTNRSPAFGGSGEDELFMNNNGAARPGYGSTNNALSGYQHQYQDVPPTPTYSYNPQSFAQTSGFSRSTSTNALPYRNQPQPQPQPPSRYASNASSYTPQAYDPSAYASTNVPQRQASYQGYNTYGQSYGSQTSPGFNHSTGSYPQSVASPALSSGFEQPLRSPSLNASPGAAQTSAYDQSYSQYPGQLSNGGGSFSSASQPPYPTATQMPVGPYYSPNEHNSLYNRGSRSNSQASPMGSPANPGSTSPGLQRHPTNAPLPSRPIDDELTWSAGHERITSDNLMQELELELGGSGQGYRPLPEPENGHYDDDLHGQRLQRFDSGATTIPNNASRTTSTRTGQTAYEPEEDDDAYGEAGLMAMRQAELDEQRFSTGFGYTDMPAMPEPSPEPAPINSLSTKALHTHPEEQGHSSDSDFAGVDLGMLGGGFGGTLTYGGDVGSPPASSGQDTGRPLPTPGYFNRAYDQGESVPAFKTAEIDYGGTGGLQPPTQHRLSFDEEDERVSLWSRQSGTESPSKDELQDLFYHPGLSNRPLPAIPGPGSDSSSMLSVQTNNRQQYQHAYSRSTDSRFGAPDNPEAYYTGNQAYNLQPERSISLAGHSHTPQVQTPARSRTDAAEERRKLARHGHQQVPSNQSFPEYETPAGSIAAFDGITLPSGRKKKFIPSKLNASDFRRCAEPWALSGLENWIREMGEGEMDLRTKTIEEALINLFTGKIPMMNVADAEVLSTHVVSLMLERGVLVPDEEWVKFGNGRISGVLWQLTGSGCYAPKVHDEEIGGRCYSHHCTRTIKKVDLEELAQDSQPADEWHVFYGLTKADWESKPKKEVERQNILHEIVTGEENYIKQLDIFRRYYRDQLRAMQPPVLKPEKRDKFLHTVFGKLDQVQAINKDHLLSQLKYRQQEQGPWIIGFSDLFREWIRKAKSVYIEYASAYPNAVYQVRREADRNILFKRFLDDMQKQKVSSKQDWTHYLIAPIQRLQRYSLLLDSVERKMPTDSEEKTNLAKAIAEIRQVTLESDLKVEEQNKRVEMMELNRMLVLRPGFHSVLNLDHLGRELIFQGDLQRMGSKGVRWVDTHALLFDHYMILAKTVTPKEGKDKKYDVSKEPIPMPLLFPESINDEPVQKQKGITAPLGRTTAAAASSTQLNKVSSNTSRPGLEHAATNSSMASGTPTGSNDTEGKILYPFKVKHLGHEVYTLYASSAKDRADWCNMIIETKTRHAKALFSQNAEPFRLRVLADAAFHYDTASMYARFSSVAVKGTPLDRAIHELESVLGPAQGVAPVCRAQVNCATSFTAFGKSVIAIGTDYGVYISEPSNPRGWQRTVQATRVTQIAVLEEFSVCVLIADKNLISYPLDVIAPVSDFSAPVNDSPRRAPQRLAKDVTYFATAKMKDRMLLFYKRKEGLHTSFKVLEPIFQKSTEKKSRLFGGRKAGGGGCAETFRDFDEFFFPTECYSLSLFQTYIAVATAKGVEMLTLDKKQPMSIPDLKAPAIANIASRIRDQKPLGMFRLNENEFIVTYEDCAVYVDKHGDVSRTLIMEYTGKQKKARGATMYGQYLLLFNEDYVEVRNAENGRLRQIIAGRDVRVLDLGVRGPTGRSTLNPQSHSNGYMQSTSAGSEGSKGTVKIAMAHPELPGRQIVLEMLLNDGHTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5I3</accession>
    <name>S0E5I3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431047.1">
        <property type="nucleotide sequence ID" value="XM_023578088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5I3"/>
    <dbReference type="GeneID" id="35401273"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07796"/>
    <dbReference type="HOGENOM" id="CLU_1034535_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="250" mass="28881" checksum="8ED5B5AD6060AA0A" modified="2013-09-18" version="1">MSYPRKLPEAVDALIGFRVECHDKNCDFASQHSINFSSIRPRCGISVVDFWHAAEDHLSWKHIRTPFVSFFRSWERALNWRKRLIERGGKGVMIVAVWLKDLSGVYDAYNIAQRLVVRQGPNSNSRGINYMEYRILACFKGDSLEIERRSISPLLKFPERELVVSIPRGTLPIYGISNLSITHQLEYEMLSLTGVRNDAKLCALVLAMCDCEMEMKEENKKMTIKATEYCGHYMSKSVIGRYNYSFDISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5M8</accession>
    <name>S0E5M8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to CTI6 Cyc8-Tup1 Interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_05992</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432135.1">
        <property type="nucleotide sequence ID" value="XM_023579267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5M8"/>
    <dbReference type="STRING" id="1279085.S0E5M8"/>
    <dbReference type="GeneID" id="35399470"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05992"/>
    <dbReference type="HOGENOM" id="CLU_020879_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="105"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="524"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT70056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="585" mass="65082" checksum="29DA86B44EC09034" modified="2013-09-18" version="1">MAPPSPRRSSRARATNSQSQQSSVSSSTSGRVERNTRSVAKPSSNKSTPSDSLSSEPFEDLDDTLLGRRRKRNHEDENDKTLKPDNFEMANGSDDLPEEEDEAVRCICDAEEYPGRPPVEGADLDFFNAIEFTEDVTGFFVQCDICKVWQHGACVGIFSAESSPEEYFCEQCRKDLHKIYTASNGQKWSKYVPHNRPSRATSRATSIAKEGNRSPKTGTSKTSRPTSASQTSKRRSTMNSRDRAYEDEQLLRAIEASKEDVPQDEQEIVTRRAKRGRSDSEESIAVNARPRDEKLASLRNPLSVKRQRTNSMSPSPPTELVEVQSYNESDEEVNTRNGAKKVRNSKNQRTKTEKEDKERQRQEAADKRKGRAERRRGEDSDPSEETPPAVAKPPATKSIETPVIMETPALALPVPDTPPASNQTVSSTAKRGGRATHKKGKGRNQYTRDRDVDGESPARSMSRDIQKNGEEPTPTHTKPTSEHRHGKSKPALHHKLNMVDMKRRVGAIMDFISRTQVDLAAEAIPGTNGNASSGEASPQKSSDSHSVENEDTAGSSGGKDFKDLNCIEMMDVLTRDMVKWQNQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5W7</accession>
    <name>S0E5W7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_06142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432270.1">
        <property type="nucleotide sequence ID" value="XM_023579433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5W7"/>
    <dbReference type="STRING" id="1279085.S0E5W7"/>
    <dbReference type="GeneID" id="35399619"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06142"/>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="71"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="470"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="529" mass="56797" checksum="E1552DA1E43D12EB" modified="2013-09-18" version="1">MLRTVTGRAAASGLVKSALPRVSQAAASTCSFAPQLRLQNKTRVAGLQLSRAIHSTSARMSQTRTESDAFGEIQVPADRYWGAQTERSLENFRINQPQDRMPPPIVKAFGILKGAAATVNMRYGLDPKIGAAIQQAAKEVADGKLLDHFPLVVWQTGSGTQSNMNANEVISNRAIEILGGTMGSKKPVHPNDHVNRSASSNDTFPTVMHIAAVLDIEGELLPALHSLRAALQKKVDEFEAKKIIKIGRTHLQDATPLTLAQEFSGYVAQLDFGIKRVESSLPDLRLLAQGGTAVGTGINTFQGFAEAIAEEVTNMTGTEFKTAPNKFEALAAHDAIVQAHGSLNTLAASLTKIAQDIRYLGSGPRCGLGELNLPENEPGSSIMPGKVNPTQCEALTMVCAQVMGNHVATTIGGMNGQFELNVYKPLVIRNLLHSSRLLTDGMRSFEKNLVAGLAANEEKIASIMKESLMLVTCLNPKIGYDMASKVAKNAHKKGLTLKQSALELQALTEEEFDTLVKPELMVGPSPYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6F1</accession>
    <name>S0E6F1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_06214</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432339.1">
        <property type="nucleotide sequence ID" value="XM_023579514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6F1"/>
    <dbReference type="STRING" id="1279085.S0E6F1"/>
    <dbReference type="GeneID" id="35399691"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06214"/>
    <dbReference type="HOGENOM" id="CLU_004222_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.220">
        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="116"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="564"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="776"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="901"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="790"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="940"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="968"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT70260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1219" mass="137677" checksum="B89D3014AEDCE5F0" modified="2013-09-18" version="1">MADTMVSIVRSPLSEASNRINSNYSTQEGQRHKPRYDRPNSSVVNNTARTSHGHPTAYFSGRPSTQQQPPVSTPQEQATLKPPSVMDDERRHSAASYDSSGSGRSKKNYKTHIGPWQLGRTLGKGSSARVRLCRHTGTNQLAAVKIVNRRMAYLVQDSSLAALSKWDNNLPEQIDGEMRVPMAIEREVAILKLIEHPNIMKLYDIWENRSEVYLILEYIDQGDLFTFINMKGRLSEEVSIFFFRQIISAISYCHSFNICHRDLKPENILISADLQIKIADFGMAALHQTDTHQLATACGSPHYAAPELLKNRQYRGDRADIWSMGVILFAMLSATLPFDDPDLRVMMARTKKGQYEMPSFLSPEAEDLIRRMLQVNPDRRITLKDIWRHPLIRKYAYLDNLCDINSQPPDIRKGFQYTPVPTKDVDPQLVRQLRSMWHMFSENDLKLKLTCDEPNDQKAFYWLLHHYREQQLEDFKPELAHSTSDYHHMKPGTWKKRVSTCEFAQPSGNGHGRSISRFTVISNATEPELAINQEPFQTERAAHSRDSQKGQSLVSVHRYSYAENGSYTGQPKRLRSGSGARRGRGTSNRNSTTGRLQSSRGSLSSMHSSRQGTPHARSLRHRRGVDFTHVRKRSTSSSNRNRSGSMPPYVTEQGSTYQIEMIRSHTPELPSLPSGVLPRLADGHDPQKRSSGQALRIALGSRYASEIFKEELRHFSSNIAKDCDEAFKSSLIEEDSIAGSLTEPDRTQYESTPFSFTIDAPEDSAADVLELSKKSFNNRPLPPLPTPTPSYNGHSLAPTPTGSRPMTGESYSEELSSEQVEVAQPVLLTRHTERRVVSAPTYTQKHKRTAALPSINEAGAAANDKARIVSAPPHTPTTKGIDRIRGIEYLSQVENSIRVVHSPGDESPVKIPEPLNVRKKVPEPEQRNSAPAAQLRELDSASQRSVDGGTTATTLSLDPPCHDAQAATKKKKLSWFKRPSKVESEPSRESVEWQDCTSYLTSSDGKRSDSTSTEAPTKKKTFHFSFWKSNKQRDSVMSTARPEQKEERPSLEINIMGKTHVSAKVSQTKWHESGSGPVRNIEVKQNWLARLFRVKPATDHICMTISRRRARQEVTILLREWRKYGIRDIQVDKQRNIVFARIAAKNFLNLKEVSFAAEVVTVIEHGKKQPLSIIRFTQERGAASSFHRVVDTMNMIFDARALVVADRNKRKMMIKTLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6K4</accession>
    <name>S0E6K4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_07689</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431452.1">
        <property type="nucleotide sequence ID" value="XM_023577969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6K4"/>
    <dbReference type="STRING" id="1279085.S0E6K4"/>
    <dbReference type="GeneID" id="35401166"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07689"/>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_1"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF13">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="62"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="404"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT69372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="600" mass="64483" checksum="0E432DFAC53ACB00" modified="2013-09-18" version="1">MADQVQHDPKQDPDYIPFPCLPPGGALNRWSTKITREHDYPGAQAMLYGAGVPNKDKMKNAPQIGVATVWWQGNPCNTHLLDLGQIVKNSIEKEGMIGWQFNTVGVSDAITMGGEGMRFSLQTREIIADSIESVTCAQHHDANISIPGCDKNMPGTVMAAARHNRPFIMIYGGTIRKGHSKLLEQPINISTCYEASGAFTYGRLHAKTNPGEAGRESSDVMDDIEKHACPGAGACGGMYTANTMATAIEAMGLSLPGSSSYPAESPEKRRECERAAQVIRTTMEKDLRPRDIMTRASFENALVLTMILGGSTNGVLHFLAMANTAGVPLTIDDIQRASDRTPFLADLAPSGKYYMEDLYNVGGTPSVIKMLIARGLLDGSIMTVTGKTLAENVEDWPSLDPGQDIIRSLDNPIKDSGHIRILRGNFAPGGAVAKITGKEGLSFTGKARVYDTEKMLNAALNKGEIKQSDGNLVVIVRYEGPKGGPGMPEQLKASAAIMGAGLSNLALVTDGRYSGASHGFIVGHVVPEAMVGGPIALVKDGDVITIDAIRNRIDVDITDEEMEKRRSEWKAPEPRVKRGVLAKYAKLVGDASHGAVTDQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6N8</accession>
    <name>S0E6N8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432565.1">
        <property type="nucleotide sequence ID" value="XM_023579792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6N8"/>
    <dbReference type="GeneID" id="35399941"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06464"/>
    <dbReference type="HOGENOM" id="CLU_065613_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal" evidence="3">
        <location>
            <begin position="206"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT70486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="363" mass="42086" checksum="C2FFFDF58125345C" modified="2013-09-18" version="1">MQPRLERLQPMLGNPLFESILWGHEYDLSKLNNDLRQRIESGQFKRLVFYGMGCSSVVSDIVKGFFLNEKIPLHVQVINDYDLDWFVDRNVMKDPTTLAIIVCYSGWSVEPCLFFETMREMTGNKNLIVLSGGGKIQHLCEEHNTSIILYKLRHADREYPLYHVQQFFSIFLDLFHKLKLTPSSYHKELQDSVNFLKTEFNDATLKKAQAIAERLKNSRIALLSTADWYVTLLKQTTMFFNEIAMVPTHRNLLHEFSHTEVAAYSNPSEKQAIITFLDSNADQYTKDKVKTLEGLFGSKDVPQNKNIEFINIDLNQDNFFKKFFYGHFFTVYVAYYLGIHSNVEGRDLISIAAKNPVVEPAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8A6</accession>
    <name>S0E8A6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable neutral amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_09097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432959.1">
        <property type="nucleotide sequence ID" value="XM_023580130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8A6"/>
    <dbReference type="STRING" id="1279085.S0E8A6"/>
    <dbReference type="GeneID" id="35402571"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09097"/>
    <dbReference type="HOGENOM" id="CLU_027816_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="53"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT70880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="469" mass="50740" checksum="EB8DCC2A865FE082" modified="2013-09-18" version="1">MDQINTAPTAPTDSKKSRRESVPDMFDTRTGEVAEINDMEKQKAAEGNAHFHRLGWKRLTVVLIVEAIALGCLSLPSAFATLGMVAGVILTVGLGFVAIYTSHVVGQVKLAFPEVSHYADAGRLMFGKFGYELVGVMFALQLIFLVGSHCLTGTIAFLNLTNNGACSVVFGVVSAIILLIVAIPPSFAEVAILGYIDFVSIAIAVAITIIATGVQAGDSVGGMSSVDWSAWPKDNLSFTDAFIAITNIVFAYSFAVCQFSFMDEMHTPRDYVKSIWALGLIEIGIYTLTGALIYAFVGSEVKSPALLSAGPTISKIAFGVALPVIFISGSINTTVVARYIHGRMFKNSIIRYINTKMGWITWLTLVTVITVVAFIIAEAIPFFNDLLSISSSLFISGFTFYFPSIMWFMLIRKGPWHSKENLLLSIANGLIFIIGMIVLVGGTYASIDDIILKFRHGEVRGVFTCEPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0E900</accession>
    <name>S0E900_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_08583</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433433.1">
        <property type="nucleotide sequence ID" value="XM_023580699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E900"/>
    <dbReference type="STRING" id="1279085.S0E900"/>
    <dbReference type="GeneID" id="35402059"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08583"/>
    <dbReference type="HOGENOM" id="CLU_005138_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="602"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="842"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT71354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="877" mass="97212" checksum="EB522B47673F0249" modified="2013-09-18" version="1">MAPKQATLGYVKSGQSTIGKFFGAKGVPPQQTKLSFSSKPKKEEVKDEEEADVKVKPGSDSEKETKKRARSEDKPKPEPTPIKKEEIDDESDGPVTKRARRSRKRVEEDEDDEEETVKKEKHASPKKSNVASPPPKVKSPEMSKTTPKAKAAKEATPEENDDSDKEEASTASASDAELDDEADVEDKPEVAAKAREKVQTKFKSKTKDPYPDWKPGTPVPYAALCTTFSLVEMTTKRLIIMEHCALFLRQVMRLTPEDLLPTVLLMINKLAPDYAGIELGIGESLIMKAIGETTGRSLQVIKADQKEIGDLGLVAVKSRSTQRTMFKPKALTIRGVHQGLMNIATVTGNGAQGRKVDGIKKLLAAADANSTGKVDINKDKGGPSEAKFIIRFLEGKLRLGLAERTVLVSLAQAIVAHEADAKGKVPSTSDLEKGESILKTVYSELPSYDVIVPAMLEHGIMKLRENCKLRPGVPLKPMLAKPTKAITEVLDRFEGQTFTCEYKYDGERAQIHYVAKDAPQELSEASQGAAKEAAAGVASIFSRNSEDLSRKYPDILAKLHTWVKPDTKSFVLDCETVAWDVDEKKVLPFQQLMTRKKKDVKVEDVKVKVCVFAFDLLYLNGEAVVEKALRERRELLETAFNPVEGEFSFATHMNGQELDEIQVFLDESVKSSCEGLMVKMLDGTESGYEPSKRSRNWLKIKKDYLSGVGDSLDLVVLGAYYGKGKRTSVYGAFLLACYNPNSETYETVCNIGTGFSEQVLEDLHTQLSEITIDRPKPFYSHSSGGQHQPDVWFEPRYVWEVKTADLTLSPRYKAGAKEGVDPSGNKGISLRFPRFIRVRDDKKADAATTSRQVAEMYRKQESVTKNKGPSVDDDFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA10</accession>
    <name>S0EA10_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433803.1">
        <property type="nucleotide sequence ID" value="XM_023581156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA10"/>
    <dbReference type="STRING" id="1279085.S0EA10"/>
    <dbReference type="GeneID" id="35401650"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08174"/>
    <dbReference type="HOGENOM" id="CLU_297748_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1079" mass="123376" checksum="674C2EA590532FE5" modified="2013-09-18" version="1">MVLASMPSPKAGLMFADIFFNSETDTMLSQAKLHQLESAPSNVKSNWLTTVQTRPVRSGSVSSDDEPTESIIHHHDTESIVAPARSSVFEYGTGTTTVLSHCDFSSATTRHGSKAMSIISKRDYSFSSSSYASELYDTQAIWKHGIDYEGFSFELDSHMQRAIDRYARVCGKPLDFGRSVTSKEFLAMVTNERLRYMPEKGSRLDKTLKKAEAFAKKFDKIMTAIKMIEVSTYDSSALVLSSCKTLLGFAGKYGFAVERFFTVLDDAMGTVVKMVEKLEASHASHRVTSIFQSSLAMIVDIVVDITASFGTHRSGGSEKTIVAQFESRFEIIIVRLTQLKAEFHMCHLNHWLECHGSVDSLLIILRGFGDFGLDSCPPAYISILMKVCLSLHKSHSEHAETLTWFRFLWNSIEKHRHEHEIISSEQWFEVYQEYLIILGVHEQHTERLHLAESFRAVILADFGATHAYYIRASIEFAKILEIDTVRYVEAVSIYEELCQIDIHCCEEGDSIIALLEIAKYRLSVLFESHCDLGHRAETLLIDSFVSLKWELSYSHEKVLVALTRIVDYHRKQKRRESITVAIKVIEEYIVGLLIEERNEIVLFDIARSLAKMYRELSSVEFGIKFIQTLKEEVLMGEKSKVEGFCGFGHEDRLAHLDRRCFIFIHAFEQLLCGYERENMLDIIIRDVYTETCLYEAWSISVRTSSRPIHMRLAAGARLIAFLELKGRQTEVRKLRTDMWEMFKGFCSTSVSSELLWQLFELTLSNVNKKVVHIDILERLVEVGLQVYKAKDFKVSLQLLKWSQVYFRQLTKTKHSHVVKLAFKISESFSRRHTHDHDHIIIELQQISSEILVEVLKVGRLDIDFGTIPFDQLNVIIRLLGERKNFSMLERILQYLWDTRMSRNWSGAATVATGRRLCEVKFAAGHQSAAMSLIESICYNLRDVYGSLHHLTVDCETLRASFHNTCGNHRAARDIHVHLLEQIGNMDSDAISGRDDLAELVTDQAKRLKWAHHSHQSKAGEDDKDESFYLSILRNAQSSVGGHHRVESASFGDAFKLDGEKMETKWKHPENWSLPVREVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA17</accession>
    <name>S0EA17_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to reductases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433840.1">
        <property type="nucleotide sequence ID" value="XM_023581199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA17"/>
    <dbReference type="STRING" id="1279085.S0EA17"/>
    <dbReference type="GeneID" id="35401611"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08135"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="332" mass="36018" checksum="496B8E17B928B707" modified="2013-09-18" version="1">MSRYTAVHVNTKGPGDARPTALQIIKDEGLEEKRQGQIFVITGTSSGIGIETLRAIAATGATLYLTARDLDKARTALDGIFDPSRMELFQMDQGSLASVRDAATAILKKTSKIHCLIANAGIMAIPDLRFTAEGHELQFGTNHLSHFLFFQLLKPALLAAGSPDLPSRVVVLSSSSHNIHGINDADNYAFEHGDYNPNIAYAQSKTANIYMANEVERRYGAKHLHATSVHPGVVATGLTRHMPPDAFKGMEHIYPMMKSVEQGAATTVWAAVGEAWKHNGGEYLVDCDVAKPAVDGDDKIIGPGYAPYAYDVEKAARLWMDSLKLVGLKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA92</accession>
    <name>S0EA92_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable RPL42B-ribosomal protein L36a.e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_07271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431483.1">
        <property type="nucleotide sequence ID" value="XM_023577504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA92"/>
    <dbReference type="STRING" id="1279085.S0EA92"/>
    <dbReference type="GeneID" id="35400748"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07271"/>
    <dbReference type="HOGENOM" id="CLU_114645_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT69403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="106" mass="12112" checksum="4285CAF587058C09" modified="2013-09-18" version="1">MVNIPKTRNTYCKGKECRKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECVKCKTKLQLALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAE4</accession>
    <name>S0EAE4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433965.1">
        <property type="nucleotide sequence ID" value="XM_023581146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAE4"/>
    <dbReference type="GeneID" id="35401659"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08183"/>
    <dbReference type="HOGENOM" id="CLU_1256109_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="220" mass="24471" checksum="2C1C9C3D558F319C" modified="2013-09-18" version="1">MYESSNLDSDVYCICVRGSADDSCVLCDHYENQCGGSVPLQLLGVAQWYWNFVKDLSDRDPGEGMDPIELHLTKRQLWRLNVALESCGNAWRELEGHLKDPNNFAILALQELTSAREIATLSALRSAGANISPDEFRDRIAASQPAYTRDDNCVVTLRDALARLSVAENTVVPSVQEKECESLPNDFPFELQDAMLSHSDSPTPRLMAVHNGMPGFFGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB04</accession>
    <name>S0EB04_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433919.1">
        <property type="nucleotide sequence ID" value="XM_023580954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB04"/>
    <dbReference type="GeneID" id="35401831"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08355"/>
    <dbReference type="HOGENOM" id="CLU_030818_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="540" mass="59311" checksum="9E57DA1C5436C9A1" modified="2013-09-18" version="1">MERAAEDRHNNSHSAHELERLHTTKEEFQTQPHHDYQRDESNPLCRSDSTPTPGSPQQSDKTLHHRRPSRAVALEKLRNRPKKLRKALIANILRWFASVLFVVAIYVILWYYSKLNIMSTTTKREFNALIIGLSLGLGMSITISLEAMAVEIRYWIISLRDWPDRETELILKAKDLTKIIQLTWVSKSRSLRSYAVAFIILNIISQIALAMLGLVYSTNTADSAAILHPGNVTIPDMSNIVTNRVLANKSQNNSQALGALRYTANSYGTIALGAVWGGMDDIPKPGTLWDNNDPLAFCGGKSCTYVFQESTARPKNYDLVVSTNRSVEATGYCRSWKVAKGGNGNEITITIDDDKKTQVNITAINGANQTTFMFNAAVPQGQTWSEVTAFEASSSQAWFYRCNVSIGPVVNAMRKEHYIGTNITSLATSAIALQGYGASSLGPTDSDRQFQSYPAESSYGQPMNGSTDDMGQVMSTFAIGVIAVTAQSAAGIIVPGMQPQNGVVLQITKWMYVHLILGLSLGVQLLLGVGIAILSNLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB35</accession>
    <name>S0EB35_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_13874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434204.1">
        <property type="nucleotide sequence ID" value="XM_023581516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB35"/>
    <dbReference type="STRING" id="1279085.S0EB35"/>
    <dbReference type="GeneID" id="35407328"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13874"/>
    <dbReference type="HOGENOM" id="CLU_027146_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="501" mass="58385" checksum="E8BAB160B16FCDC5" modified="2013-09-18" version="1">MLIEELESLRDSIRSLKLDMLRATIRGESVPEVFPHELTYKCLVSGIRHHDGFADEIRGKSGHHSIERAFNARNIMSGRVPVMEKPEDIPYCFWNPDVPGQDILRRLLEDHPTVLMRYQVGRACAVGGHVELYKELDILPDVSIAEEARDNLPVSQEIYELVMDAPILYQVMDDYNLCLFDKPQVGACLNGGTCVRSTLDERQPIHYEIFPPPFDITEDWCLGASGKRLEERPIPTNTLSLLYTPLPRHLPTVDKDILILMAAYTGNIDRYARLRRPRTINGEMQCIVRGIYHNTFFARWCYNQPHLAVLRKFVHARFIMNDDLTWFNHNQPISKDDLPRVIWYPQHVDPTTYIELLRLLPELKQMVAQALVVCNEPNDFLCLESELTPEIYGEITNGVRSPLLREFIDQRVTYEEEEKLADWTELLHDCHDIAPYDHLVSKEMKPHFTRALEELTLDDVGFENRRAYPPDVKDARDLMRYISAFPHKPRDHYREEQERDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB60</accession>
    <name>S0EB60_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable MUP1-High affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_13886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434192.1">
        <property type="nucleotide sequence ID" value="XM_023581503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB60"/>
    <dbReference type="STRING" id="1279085.S0EB60"/>
    <dbReference type="GeneID" id="35407340"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13886"/>
    <dbReference type="HOGENOM" id="CLU_013661_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT72114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="522" mass="56970" checksum="CF7B9E556413BE43" modified="2013-09-18" version="1">MSNDDLKGLEPKANKTNYVGSDSEEGRLHVAAENKRQIGVLSASMLIFNRVIGTGIFATPGSILALLGSPGLALIIWVVGSIIAAAGTAVYLEWGTGIPKNGGEKNYLEFIYRKPKFLVTGIYASYIILMGWASGNSVVFGEYILHAANKEVDRWNQRGIGLACITTAFIIHGTALKWGLRLQNALGIIKLIIVFIMIICGFVALGGHLKTDEKPNNFSNAFEGTTGSAYGVVTALYNVIWSFVGYSNANYALSETRNPVRTLKIAAPTAIISVSIIYILVNIAYFAAVSKAEIIASERLVAASLFRNVMGPAAERAMSVFVALSAFGNVLSVIFSQGRLVQELGREGILPFSRLWASNRPFNAPLAGLFEHWVICVIVILAPPPGDAYNFILNLISYPLAIVNTFVAGGLVHLYLHGAKYNWNPPIKATLPVTVFFLLSNMYLVIAPFIAPDDPSQNQYKSMPYYIHCVVGIAILVAGAIYWLIWAVILPKIGGYKLVREVHVDEIDGWESNRFHREPINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBJ0</accession>
    <name>S0EBJ0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to retrotransposon HobS hobase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434342.1">
        <property type="nucleotide sequence ID" value="XM_023581681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBJ0"/>
    <dbReference type="STRING" id="1279085.S0EBJ0"/>
    <dbReference type="GeneID" id="35407180"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13726"/>
    <dbReference type="HOGENOM" id="CLU_773984_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="201"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="358" mass="41070" checksum="4B6E4328C788E4AA" modified="2013-09-18" version="1">MNTEQIDQVLEPVQGPDELESQESTLENLIDDLPTEEAEPTEDQEDDGTKYTQARFELLPTPPESPFSSFLAQIGIQSPARKEGLDVDLKILNQAFNAGTMAVPIAKQEGKLITKATRSRYIRGRLKPRWEAQKSHMNLVPDKERLHRRNLPPAPSSFGSLTGHRFEEEFKQAQKDHLESHKQMRSWSEISRLDPRIGDSQVLDCMWVFTYKFDKHGYLRKCKARLVVRGDQQYKSSTDDTYAATLAGKSFRTLIAIAAKYDLELLQYDAVNAFVNAKLQSNVFMKLPPGYRSGEKQDRILLLHKALYGLRIAPLLWQMDLGDTLEAQGWNQVPNEPCCYRKENILMFFYVDDIRICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBR6</accession>
    <name>S0EBR6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to YJU3 Serine protease, localizes to lipid particles</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434422.1">
        <property type="nucleotide sequence ID" value="XM_023581777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBR6"/>
    <dbReference type="STRING" id="1279085.S0EBR6"/>
    <dbReference type="GeneID" id="35405656"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12200"/>
    <dbReference type="HOGENOM" id="CLU_026209_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="26"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="299" mass="32848" checksum="6E88A76147663C6C" modified="2013-09-18" version="1">MSTETEGTFELADASLHTKTWTPEGPIKANLVHVHGFSDHVDWYNDVYRIVASHGIQVFGFDQRGWGRSVKQPSDKGNTGPTSRVIADIATFIESKLPSDVPVFVLGHSMGGGEVITLAADPQYAKLVSQVRGWLLEAPFIGFAPEEVPSSLKVFAGRLAGKILPKFQLKHVLDVANLTRRQEVAKGFKEDPLCHDTGTLEGLASLLDRTGALQSGSVRLGKEVRSLWLGHGDHDKACSYQAAIDFAQKQDIEDKTIKTYVGGYHALHVDLCQGEYAKDITDWILERSSQDQKPIEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECS5</accession>
    <name>S0ECS5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_08291</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433696.1">
        <property type="nucleotide sequence ID" value="XM_023581025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECS5"/>
    <dbReference type="STRING" id="1279085.S0ECS5"/>
    <dbReference type="GeneID" id="35401767"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08291"/>
    <dbReference type="HOGENOM" id="CLU_015495_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="285"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="443"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT71617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="593" mass="65292" checksum="11B849959F75A21B" modified="2013-09-18" version="1">MSLFVLAETPAGYGLFKATDKKMLKNEELAAELGRPEKVVEMLKLKKFVKFDSAATALEEAASLKEGKVPELLTQLLDDLKSEKKASLAVADMKLGTAISNMPSLNISPVSGSNTMDLFRGIRGGLPNLIPGLLEENFDRMALGLSHSMSRHKLKFSADKVDSMIIQAIKLLDDLDKELNVYAMRTKEWYGWHFPEMAKILNDNLAYARVILAVGMRTNIADSDLSEILPEEIETSIKAAAEISMGTEITDEDLDNIKLLADQVIVYSNYRTQLSSYLESRMRAIAPNLTALVGYLVGARLIAHAGSLISLAKSPGSTIQILGAEKALFRALKTKHDTPKYGLIYHSSLIGQATGRNKGKIARMLSAKAALGLRVDALGDTEDDADEEERAILGLSNRIKLENHLRKLEGKPLLPKGANVTPSGEIVGAGQFTLKETRRYNGDADGVADDEETNEATPAKKLKKAKKLIEEVDEEMKDAENDSDDEAATPGKPKKLSEADYERLAEEAGISVKKFKRKYERGDVEMNADGTPKVVSKKELKKLRKAEEKATPSKSQAAAEETDGKKKRKHDDSEDEEPKKEKKQKKKKRHSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECS7</accession>
    <name>S0ECS7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_06144</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432272.1">
        <property type="nucleotide sequence ID" value="XM_023579435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECS7"/>
    <dbReference type="STRING" id="1279085.S0ECS7"/>
    <dbReference type="GeneID" id="35399621"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06144"/>
    <dbReference type="HOGENOM" id="CLU_000288_67_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120105">
        <property type="term" value="C:mitotic actomyosin contractile ring, intermediate layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034973">
        <property type="term" value="C:Sid2-Mob1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903501">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903473">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902846">
        <property type="term" value="P:positive regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902854">
        <property type="term" value="P:positive regulation of nuclear migration during mitotic telophase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905758">
        <property type="term" value="P:positive regulation of primary cell septum biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21776">
        <property type="entry name" value="MobB_Sid2p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="262"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="566"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="639"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT70193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="662" mass="75681" checksum="DA7D7F0CE70298F5" modified="2013-09-18" version="1">MASFMSSFFPGGKEKNPASENGSSRPATPSTRVDNFLNPASTPQGSPSKKTNPPGSHDLPSAFESALTLNPPVMEPPLKLGRPQSVVAPLSPGKTKVQPLDESNVNVDESVVHKTRPASPQKKQGQENTPPTSRLAGTDSPHQHSHAAVTRQQHYEHRERPNTPATKKFNTARGLTPEEREILQKPNVKRLVNVTQLYFLDYYFDLLTYVGSRQNRLAAFKNEYPPPPETDEQTHNQMWTKYTGRERANLRKRRVRLRHGDFQILTQVGQGGYGQVFLAQKKDTREVCALKVMSKKLLFKLDEVRHVLTERDILTTAQSEWLVRLLYSFQDEKSIYLAMEYVPGGDFRTLLNNTGVLSNRHARFYIAEMFCSVDALHQLGYIHRDLKPENFLVDSTGHIKLTDFGLAAGVLAPSKIESMRIKLEKASESAVPFGKPMDQRTVAERRESYRTMRENDVNYAKSIVGSPDYMAPEVLRGEEYDFTVDYWSLGCMLFEALTGFPPFAGATPDETWRNLKHWKEVLKRPVWEDPNYFLSNRTWNFICTCINSRTRRFSNIKDIYAHHYFAEVEWDVLRQTRAPFVPELDSETDAGYFDDFTNEADMAKYKEVHDKQQALETMAEREDQMSKSLFVGFTFRHRKPATEEGGSPRKRIPTDETFGTMF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECT9</accession>
    <name>FFSC4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Terpene cyclase 4</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Sesquiterpene synthase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ffsc4</name>
        <name type="ORF">FFUJ_12585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="ChemBioChem" volume="14" first="311" last="315">
            <title>Genetic dissection of sesquiterpene biosynthesis by Fusarium fujikuroi.</title>
            <authorList>
                <person name="Brock N.L."/>
                <person name="Huss K."/>
                <person name="Tudzynski B."/>
                <person name="Dickschat J.S."/>
            </authorList>
            <dbReference type="PubMed" id="23335243"/>
            <dbReference type="DOI" id="10.1002/cbic.201200695"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Terpene cyclase that catalyzes the cyclization of farnesyl diphosphate (FPP) to the sesquiterpene koraiol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E,6E)-farnesyl diphosphate + H2O = koraiol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:66640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:167323"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:66641"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 3 Mg(2+) ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sesquiterpene biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="2">The 2 conserved active-site motifs D(D/E)XX(D/E) and NSE are required for coordinating the divalent metal ions that stabilize the PPi moiety of the substrate.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal WxxxxxRY motif is frequently found in terpene synthases and is important to guide product formation.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Abolishes the production of koraiol.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECT9"/>
    <dbReference type="SMR" id="S0ECT9"/>
    <dbReference type="STRING" id="1279085.S0ECT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12585"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000452516" description="Terpene cyclase 4">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="D(D/E)XX(D/E) motif" evidence="2">
        <location>
            <begin position="118"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NSE motif" evidence="1">
        <location>
            <begin position="260"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="WxxxxxRY motif" evidence="1">
        <location>
            <begin position="341"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>(2E,6E)-farnesyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>(2E,6E)-farnesyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P9WEY7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9UR08"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23335243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="23335243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT72694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="365" mass="41636" checksum="779066CBD2109A51" modified="2013-09-18" version="1">MVPSLITPPPSRSGEATPQKDACLNPVNIAEPEGHWIKLPEALFSSIMAVEPEVNPLYRTSKALSDEWLKTALRMNDKTAVIWSRLDIAYMSAICAPHADLETLKLMNDWNGWVFAFDDPFDEGTFANDPIKAAEEVIYTLATLDNIHPVVSPDENPLRHTLQSCWMRFRERSSPSLQYRWKKHLTMYCVGVLQQVGVQHRATRPTIEEYMDMRAGCVGAYPCIGLMEFAEGIDIPQNVMDHPSMQAISRITCDLVTLQNDLCSYRKDLIQGEESNIIFILKDQGMTDQQAVDQIGEMLYDCYRRWHMALANLPFWGEGIDRDVIKFVTGCRNIALGNLHWSLYTFRYLGNDGPEVKRTRMMKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECV6</accession>
    <name>S0ECV6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_08250</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433736.1">
        <property type="nucleotide sequence ID" value="XM_023581070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECV6"/>
    <dbReference type="STRING" id="1279085.S0ECV6"/>
    <dbReference type="GeneID" id="35401726"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08250"/>
    <dbReference type="HOGENOM" id="CLU_002833_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="8"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT71657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="399" mass="44723" checksum="A8D011C62AE1B60A" modified="2013-09-18" version="1">MGGGPEGFRTVAYFVNWAIYARQHRPQDLPVENLTHVLYSFANVRSDSGEVHLTDSWADTDIHWDGDSWNDQGTNLYGCMKQLNLLKRRNRNLKILLSVGGWTYSSNFKAPASTPQGRDTFAKSCVDLIKNLGFDGIDIDWEYPQNADEARDYVELLGAVRREMDAYAQTLSQPYHFELTVACPAGATNFQKLDIRGMDRYLDFWNLMAYDYAGSWDSVAGHQANLYPSPDNPQSTPFSTSAAIDFYVRSGVSPGKIVLGMPLYGRAFQNTDGPGRPYQGTGEGTWEAGVHDYKKLPLEGATEYGDRACCASYCYNPQTRTMVTYDTPRVAWDKAEYVKKWKLGGAMWWESSADKTGDQSLITTVVNGFGGQGALMRQDNCIEYPATKYDNLRNGFPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDU3</accession>
    <name>S0EDU3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434908.1">
        <property type="nucleotide sequence ID" value="XM_023582363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDU3"/>
    <dbReference type="STRING" id="1279085.S0EDU3"/>
    <dbReference type="GeneID" id="35406179"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12723"/>
    <dbReference type="HOGENOM" id="CLU_606963_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="450" mass="51338" checksum="A1EB7C69C8A90BE1" modified="2013-09-18" version="1">MTYTSRHMRRPGLRPALYYYICFGLRDTTPRPIPATPYQPQLFKRSKEDEAQLKKLCARHSRDWSQIDAQAYEDIIDRDEARKDASREPQRLVIYSYFEHLNLPPLPPPLPRCSTSVRIKRAENHSNESVRPFMLACEKGLLDEVKAWTEDGERIEELQQLGLQDGLVYAARANEIEVVRYLLDERWTHLNGEVVREACDNLSLPLFELCVQHGYHPNQQIPSLNGYFGVAINHCVQDVDITRFLLEHGGDPDLAPFKDGRLHNWGEKATPPMDRTSGLALDLAVEKSPMIVAQMLLKHGAHPQYSRPLHRAIKRLHCHPIPGAQTDWRPLMEMALSHGAEINARTYSGGTALSRAVHYKNWEIVEFLIEKGADPFVKCPASKHDSFDSALKFEDQPWQRSKEVKEYLKGLMSGSKLEIGGEALEEARKNPLVQIIEKVKSRDADGVETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEC1</accession>
    <name>S0EEC1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435384.1">
        <property type="nucleotide sequence ID" value="XM_023568025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEC1"/>
    <dbReference type="GeneID" id="35403476"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10009"/>
    <dbReference type="HOGENOM" id="CLU_044233_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="477" mass="53515" checksum="8F5AE0058666768D" modified="2013-09-18" version="1">MPVGPFDRRKKRSRCLACAASHLKCSGNVPCSNCVRRRVECAFEKQKPKQIWISQDESGKKTVAPVPAATCKNQSPRLDINPTGDQIYYLSHYFDTFLRRNSCNPRTEIFTDVIGLMKDQRSGTFLHDAVLSLGAMQAVKLNASEGVDPSKTYNLAVHHYSKSVFGLRNALEEFDQEPNARHRILWTTHLLGLFELMTDATGEGWIQHLVHGTSKALVVAGPTSCKSGHGQRFFTEIRIFEVCRAIIFNEPTFLAKPDWRCLTREIRTKEQGDSDCLDELLDIIVSCSTLRVRAINLLYHSDADSVDVTKHLDEAFAVAQEGFRLRQSLVDWEAKDGPSEQQSAENVSGGFSPLTKAFFSATSIYLSGVFDYEIPYWQDKGIVAPNLSEEEIQMHVVNILTHTNIVLYNSSISSLLVLFPLRVAGARSWQGWQQDCIMQNLLVIERTFPVAAAFRADLMGVWARMSPPSYSDSPLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0EED1</accession>
    <name>S0EED1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435088.1">
        <property type="nucleotide sequence ID" value="XM_023567761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EED1"/>
    <dbReference type="STRING" id="1279085.S0EED1"/>
    <dbReference type="GeneID" id="35406364"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12908"/>
    <dbReference type="HOGENOM" id="CLU_013387_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014390">
        <property type="entry name" value="Acid_Pase_Asper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000900">
        <property type="entry name" value="Acid_Ptase_Asper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005146101" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="8">
        <location>
            <begin position="84"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="445"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="7">
        <location>
            <begin position="598"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT73010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="720" mass="80099" checksum="FCF43494D1FC5525" modified="2013-09-18" version="1">MKSAHFFTGIFAALTQAAPTVDETYQYNGPDVPIGDWVDHTIKGDGTGFIRLVEPPAVKPAHDKPTNNVNVISLSYIPSQSGGDTVGINIHYQTPFGLGQVPWVNWGVSNSSLDKVAPGSTVTYERTPPCSRVHVTQCSQFFHNVQIENLQPGTMYFYQIPAANGTTVSPVLNFTTAQAVGNPSQFSIAINNDMGYTNANGSYFFMNQHMNDEDGLAFVWHGGDLSYADDWYSGIVQCNSSAWPVCYNGSNSSLPNNDTNPDYFDTPLPEGEIPNQGSPRGGDMGVLYESNWDLWQQWMNNITMKIPYIVLPGNHEATCADHDNTPFVLSSYLNENKTDTPMSGDNPNATLTYYSCPPSQRNFTAFQNRFFMAGDKSGGVGNFWHSFDYGLVHFVSIDTETDYANSPDKTFREDVQKAKKEEDCKGKDKDKAKCKPEKPEPTGYQCTKIDLCDEFETDDLEEETYLQSGKAHPLRNETHITDAGPFGYIDGSVKDNRAYQQYHWLREDLKKVDRCKTPWVIVMGHRPMYSSHDASNYHLHLREAFEGLFLKNKVDLYIAGHVHWYERLKPIRNCDVDHRAIKNDSEQNGIYEVRPGHSMVHLINGAAGNIESHATINKSLPIPDITAHRNITSFGFSKLTVFNATTLSWKFIQGHDGKVGDELTVLKNASLTCKDYKTYSSPSSSGSSGSSCATECSGSGVLAWLYCNVYCASFGEPLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0EED2</accession>
    <name>S0EED2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Extended synaptotagmin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_09999</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435394.1">
        <property type="nucleotide sequence ID" value="XM_023568036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EED2"/>
    <dbReference type="STRING" id="1279085.S0EED2"/>
    <dbReference type="GeneID" id="35403466"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09999"/>
    <dbReference type="HOGENOM" id="CLU_048762_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21670">
        <property type="entry name" value="SMP_ESyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051634">
        <property type="entry name" value="Extended_Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039010">
        <property type="entry name" value="Synaptotagmin_SMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761:SF1">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17047">
        <property type="entry name" value="SMP_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="16"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="188"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT73316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52327" checksum="B99F9421C84FA355" modified="2013-09-18" version="1">MDNMASLKDTLTASGGAESAGFLNDIIAQLWPNINVAGGKIIKDVVEPMLDQMLPGPLANLRFVKLDFGPTPIRFSNVDVHKTELEGIKLDMDLDWDGKCDFELDASMVPKIGIEHVKMKGRLSILLCPLTNVIPLIGAAQVAFINPPELSLDFTDAANIADFSLIDKTVRKVILNIISSMAVLPNRFLVKLDSSNDYFKTFQPHHGVLRLTVDNATEITGEKKSGAKRLLQKLVKDIPDCYCDVNVGAEGEWRTSTIKNKHDPQWNETHDFLVTDYEQRITIDVNDEDLGGDDDIGIATTTVKQLLLNGGSQTLTLSHKGQPLETKVTIHGKFFNFVGESNSISASSQNEGEICGLATVLIASVNGLNGQRDELKPSVKVTWGDKEFVTPAKSYSPGTDIFNPSFDTAFRFPITAEQLSNPHSFKLSLQNGTSEQGSVDIPFDSVTGADGMNREEEFDVGSGATIRARFSVRGLQLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEH9</accession>
    <name>S0EEH9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to hydrolases or acyltransferases (Alpha/beta hydrolase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435262.1">
        <property type="nucleotide sequence ID" value="XM_023567880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEH9"/>
    <dbReference type="STRING" id="1279085.S0EEH9"/>
    <dbReference type="GeneID" id="35403607"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10141"/>
    <dbReference type="HOGENOM" id="CLU_034451_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495849" evidence="2">
        <location>
            <begin position="20"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="203"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="438" mass="48939" checksum="D96127075C5DD547" modified="2013-09-18" version="1">MRSTSLFSAILLGATIASSSIIPRDSAPSTSPKEPEDPIILLSKDESFHFELLFTLGNTIFGAGDVNDVLAAAKHVKAGNSTSWLETFQVLAEYTKTQAEDADNAYDPLNVREAWFAASSYYRQADFYNHANWTDPRINSFWLEQRAAFDKALATLPIPGERIQIPTDNFTIEAIWYTSAADNVKRPTLVIGNGYDASQEDSYHSFVVPALARGWNVMTYEGPGQPTVRRNDDIGFIPDWEKVLTPVIDELLSRKGCFVDEDRLVLVGISMGGYLAARAAAFEPRIKALILNGGVWDVYEGYASQLGPDMKKLFAAGKQEEFDEAVLPLLDSPQAPTMMRWGLGHGLWCFKKHSPYLWLQSLKQYTLKNVVDKINVPVLVVDSEFEGFFAGQPEVVKDALGDRATYKFFNGTAGYHVQVGAGQEWNRYQFAWLNKIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFU9</accession>
    <name>S0EFU9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433342.1">
        <property type="nucleotide sequence ID" value="XM_023580591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFU9"/>
    <dbReference type="GeneID" id="35402156"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08680"/>
    <dbReference type="HOGENOM" id="CLU_078011_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="305" mass="34934" checksum="6EC9963EBF58935C" modified="2013-09-18" version="1">MTGNHDSPNSVLSHVPRELDPRAPPAPLDLLSTVSSVFHQRSERLRREALALTDAEIEAGFIATREARIKEKLEKLEEEETSEDEWAEEEYEDEIPSREDVEAFVNGVIDREATGSVLERAIGETVEDHRKRIETLEDRIQGYQLSKAVLEDVRGDPPRYVEGFPVNLVNAFLRLRPRIAVMNTGGFICLQCQVKGKRCSRNMNYSPACERCRRHGDPCLVKDFTHPVVAVRWWFARGQETDHIEQVELEWWLERLANKGRTEGIQALPVWPEVGNNPSNNRGEEELPQKWQHILKGSAKRKINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFW5</accession>
    <name>S0EFW5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435727.1">
        <property type="nucleotide sequence ID" value="XM_023568545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFW5"/>
    <dbReference type="STRING" id="1279085.S0EFW5"/>
    <dbReference type="GeneID" id="35403009"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09541"/>
    <dbReference type="HOGENOM" id="CLU_034979_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="284" mass="31576" checksum="677292DB1793E2B4" modified="2013-09-18" version="1">MNVLHIFAGLAVVVPGIYMFTASSAQSTIKNKRVCLLIAHPDDEAMFFSPTVLALTRPENGNHVKILCLSTGDADGLGEVRKKELVKSGLALGLQSEDDVFVVDNPTDFPDSMTRMWDKNLIARLLGSTFAPKFGQERKNNLKPTANIDILVTFDSNGVSSHPNHISLYLGARSFIQALTTASEWPSPVDLYTLSTVGIVRKYSAFMDFIPTLLSSIGVKDQDKERPESLVFMNQLVGRGAYGTAWSAMTQAHRSQMVWFRYGWITLSRYMVINDLRLEKVKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH44</accession>
    <name>S0EH44_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to pathway-specific regulatory protein nit-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_10171</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436167.1">
        <property type="nucleotide sequence ID" value="XM_023567846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH44"/>
    <dbReference type="STRING" id="1279085.S0EH44"/>
    <dbReference type="GeneID" id="35403637"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10171"/>
    <dbReference type="HOGENOM" id="CLU_277069_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="923"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1107"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT74089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1146" mass="127875" checksum="A7718E315B7C8865" modified="2013-09-18" version="1">MSSQGNGVIMVADDGPSQRPPKSLAKACLACRTKKIRCDAVKPECGNCASQKRECIYRKETPRKRPTFSQIAKLQRDLAALKVFLLTLKRSSPEEREKLLDAAVDEDGAVNLLDSTEPGPPEEASSRKNTSQPIDRSATTPIVSSDDELNIANFISVDDAGTTNSFGPSSALHNPARNDRGTPSSRQSTTTTEHVKNELIANAALQRHLEHRLTRHATIAGEPTELALHLLNLHWARQHHTFLLTYRPVVMRDLECSGPYCSAFMLNAIFACCSKFSPRPDVRDDPDDASSVGRRFFKRCDELLSSEYLLIRPHISTIVGLVLLGSTYNARGETSKGWLYTGYALRMVYDLGLHLDPKQTTEDPEEIEIRRRVFWGVFVCDKLQSLYMGRPVAINLRDSQVSREFLDLYEEMEPFYPSVLATGSSSRLDENMGDAIPRYSVSTFQQLCLLSKIMTTIINRFYVVGATFSNAQIDLQKIEQALHQWRHKLPSELDFQPWLSTSTAVQTPNIMVLQNVYYSLIILVHRPFISDDHLRSTATAGRSWEQCTVAARSITSIASVYKSTYGLNGAPYVLAYTVYVACTIHVRNAASQSQTRDHLTMLKSSLECLDELCTANPGVAKPANSIRRLIEANHLNLVTEEPHSCRQNDMSFDLDIIHSTFSVNELSNTGSDMFRMADFEYAKRRASAGFCKDSSGVLNYPEARSINNDQIPKPKVIYADSCGSKYGKWSLFNQVESWQMEVAVETVKTGTTLIENTVPTTRYGDLKTADLVEIEGFRSTAAVIHEYLHGKASRPLLIAVFGQPGTGKSFGVKEVIKTVLSSFGKGLKKDWKPIEANLSQFKDQSDLSGIFDDVRDMTISGDIPAVLFDEFDSALDKQALGWLKYLLAPMQDGKYLQSGSVRSLGRAIFVFIGGTSSTFEDFTGESINSKKDDESQSQTNDAQSLQKQKWAIKDKGAKKPDFVSRLSTHINVAGPNKSGNNKDDKMWVMRRAMLLRNMLERRLGTKDKADKSISVDETLLTALLKHEKIPHGSRSMELLLQMSRLSEGQKFDLSALPSGNQLGMHVDLEEFQKDLATACFEQDIRPIDTVLYNRHMWCTWEAKENVAKSKAQPMPSGETSSPQRKEQLDISVEESGVGQSVINLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHV5</accession>
    <name>S0EHV5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434036.1">
        <property type="nucleotide sequence ID" value="XM_023581322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHV5"/>
    <dbReference type="GeneID" id="35407502"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14048"/>
    <dbReference type="HOGENOM" id="CLU_039184_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26975" checksum="C41564198825F27C" modified="2013-09-18" version="1">MPRIIHLVRHGQAVHNLCEANNVLPDTVLTPLGQEQAKGLISKCPELANVDLIVSSPLRRTLQTTLLAFSSQLERGLQVVALPEVQEVSDMNCDTGSDLNVIKAEFQQQPVDFSLVEPGWQIKDGKWAPVVGSVLERARAARQWLSERPESEIVVVTHGCFLHFFTDDWVNSVNPDGTDWANAEVRSYTISHDEREGPVLCETRESRERRGVEPVATTREEQLELRQAALKAALEWGLIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIJ4</accession>
    <name>S0EIJ4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to vacuolar protein sorting protein Vps66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_13791</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434281.1">
        <property type="nucleotide sequence ID" value="XM_023581609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIJ4"/>
    <dbReference type="STRING" id="1279085.S0EIJ4"/>
    <dbReference type="GeneID" id="35407245"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13791"/>
    <dbReference type="HOGENOM" id="CLU_048121_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="11">
        <location>
            <begin position="105"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT72203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="322" mass="35471" checksum="37B59D888C55935F" modified="2013-09-18" version="1">MEKYSQFRDRATGIAPFLPVSTPVSALATFTHAALFLFRLPFFIAYFLGYFLFFHFLPLPVIFRKVALWGLMAIPGIWWVDLQLDGVKRGTLADQPRERFPHPGSVIAANFSSPIDAIYLAAIFDPIFTISYPDTRKVQRVSLLGAVLAALSPVKTGPPKNAKLVEIKDLLDSNPGQIIAVFPECGTTNGKAILPFSPSILQTPADVHIFPVSIRYTPSDITTPVPGKWFRFLWDLLSRPTTCIRVRIAEGQINTSAAKTNGVTPSSSELRNRSDASSSVSPDEQRVLDRVGEALARLSRVKRVGLTMKDKAAFVDALNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIK8</accession>
    <name>S0EIK8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435770.1">
        <property type="nucleotide sequence ID" value="XM_023568598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIK8"/>
    <dbReference type="STRING" id="1279085.S0EIK8"/>
    <dbReference type="GeneID" id="35402961"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09493"/>
    <dbReference type="HOGENOM" id="CLU_1115829_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496009" evidence="3">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="271" mass="29391" checksum="8FF8495711A8BAAB" modified="2013-09-18" version="1">MQRIIWTLQLFQLYICHSNALYAKLSTATETLQPSQTPKRPERLEQRAVPSEMITCGYKNGGPTAMTTVESGSALCRFSTQNGLWGICKSTGDSKCTLAGRCRDQHDCSDGCGTTENLKFRMTSCKRVECCNFAYLIMDEGHKHTYVACGAVVARYLGHHPKSPGIDKSRFTNDIDKSDMGAIFGGVTGGLAVVCGTAVAIIYLLRESRAQKPEATPEKGQGMIEVSGQTETDNGPKELVGLKASDVPANLQPDKLHGTLAPRLPHPVELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIY8</accession>
    <name>S0EIY8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_09333</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435920.1">
        <property type="nucleotide sequence ID" value="XM_023568777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIY8"/>
    <dbReference type="STRING" id="1279085.S0EIY8"/>
    <dbReference type="GeneID" id="35402802"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09333"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="62"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT73842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="528" mass="58473" checksum="404906728770D6A6" modified="2013-09-18" version="1">MSTFKGDDAPSQQHAEDVESQIAKPDLHPQNGDAVAQMIGAQHIEVTEEDNKRLRRKTDKHVLSILVWVYFLQILDKSVLGYGAVWGMREDTNLSGNEYSMVSSMAPIAQLVWLPFSSWLMVKIPHRIFMASLVFGWGAAQTCMAACTSYQGLLATRFLLGLFEAACLPLFSVITSQWYRRAEQPMRVACWYGTNGLANMFAAALSFGLGQINGSLASWRILFLFAGLITVITAPVVYLVLDNDIPSARFLTEHEKLQTIERLRANQTGTGSRNFIWKQAFEALIEPKTWLFISMALCLNVTAAVTNTFGPIIVGGFGFDKGVTSLLNIPFGAVQLLVIFPASYLAHRYRVKSIFLIAVMLPVLAGAVMLHQLNRDHVAPLLAAYYMLAFLFGGNPLIVSWMISNIAGTTKKSVIMSLYNIGVSAGNIIGPLLFSSKDAPYYKPGLTKTMGITGALIGVILLQLVNLMFLNKMQERKRVKNGKPAKIRDLSMEHHYVANAQDNDEDGLGQNAFMDLTDSKNDEFVYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ82</accession>
    <name>S0EJ82_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437119.1">
        <property type="nucleotide sequence ID" value="XM_023569983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ82"/>
    <dbReference type="STRING" id="1279085.S0EJ82"/>
    <dbReference type="GeneID" id="35404584"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11120"/>
    <dbReference type="HOGENOM" id="CLU_004498_0_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="478" mass="51980" checksum="4BD34694D3F704D7" modified="2013-09-18" version="1">MTVLTSSPTTQWTREPVDVAIVGGGFSGLAAAKDLVAAGKLVLVLEARDRVGGKVYDVEVKDGNGQKVEAGAEFVCKNHKRLLTLASELGIKTFPTYIEGNMLMWIPGQGPLLYDPVKTQGLPPLSEEDIAILADITVQFNEMASEIDVHQPWMHPKAKEWDRLTLSSWLDGFTRDGVARGVIDMTNRAVMSAEGEDVSLLSAVINVARTGDAETKGRMEMLTNVKNGSLEERIEGGPQNIAIKLAERLGSDRIRLQAPVRQILQNDDGYLVVGDSFHVQAHKVIIAIPPTLAGRIVYQPPLPAARDQLCQRVPMGSIGKVIAIYKTPFWRDQGLSGEVASLEGVSQSTFDSSPPDGSFGAMMGFLEANEMRRLDDASEEEIFAAVTEDFVRYFGPKAREVQSWVLQRWDNEEFSRGGHTGLFPPNVWTQFGPALTKPVGGIYFAGTEASSYWAGFMEGAIIAGEAAAKQALESLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKA5</accession>
    <name>S0EKA5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_11281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437312.1">
        <property type="nucleotide sequence ID" value="XM_023570161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKA5"/>
    <dbReference type="STRING" id="1279085.S0EKA5"/>
    <dbReference type="GeneID" id="35404743"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11281"/>
    <dbReference type="HOGENOM" id="CLU_021753_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT75256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="86150" checksum="116534427763A4AF" modified="2013-09-18" version="1">MSATRFLRKLSLRNSSPQRAAYIAALGLVGIQVGIGIIMKTAQSGGSYAFSPSGSITISEFLKLILSSIFFYRECKTRAQAGVGPSTRGSDTAYASLADDHRDLEIQDKDGDASSLTAMDSDDEGSRDSGSTSAALPFRIRTFWGYVRGEVRNDVRFGFYNLALIYILINNSLFLSYKMADPGTIQLTKSGVTLITALVMIATLNQQVSKTQWMAIAMQLSGLIVTQYQPGKGALYPLDTYALLLFQVFLSASSGVYNQVLLKADDSSLHANNMILYASGTIVNFVCHITIKCVSSNEPGFFEGYGSIHAILVIMSNVFIGLAITAVYKYADALVKCFATAFSTGILLYLAPLISDTSLSFLVVPGTFIIFVATWLYMENPAPKPTATKSDSDPKTGFFSKLGAIVENKRILFIFINTLITVMAVMALAMYQVAMPTKSISTAPTDASTLAVATTQEADAPKIVTSPFKNTMAFIRWNSVHPERIPTLMKYKPFFRDIHISMPDMMKAEGRKPEYHNITHDQSTLTFHIYQQVADTMQLILDEDPEIDGLLYYHFDAWIDPLAWGGIDRNKIYFPMTWPEMKPVGPQFSCMNDTKGYDWGGWGGPHYHLKAQLASAQLDHLDLGFKIDINEFCVGWSDIYFIPRKFFKDYIIAAPIFKSFDVFHEVGIPTMLHIIEQSHRESPYVPAMELFSDCWGYCCKDNPSIYDVTTYRCGHRLDYRNEQVTGAFYEKLDAEAKFLGQPMNGSHVANLTEMFPPIKEEDKAKLPARRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKC7</accession>
    <name>S0EKC7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_12753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434936.1">
        <property type="nucleotide sequence ID" value="XM_023582396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKC7"/>
    <dbReference type="STRING" id="1279085.S0EKC7"/>
    <dbReference type="GeneID" id="35406209"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12753"/>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT72858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="353" mass="39552" checksum="FB161739ABF28878" modified="2013-09-18" version="1">MSLPQPRLNIPGSKSMVSVAVIDTTSTIKAKTSLVVTPHISGHDEFNCPCYCFLITHPTTGRKVLFDLGIRKDPENLAPKTYAFTKAMEISSERNVADILGDDEVSTITDIIWSHHHFDHIGDPSRFPAKTALVVGQGFKAEFFPGYPAREDAWILESDYAGREVHEIEFTTAGLKIGQYDAFDYFGDGSFYLLDCPGHTIAHMMGLARTTPTSFVLMAADCCHHGGEFRPSPFVPLPDVIDPNPLVHSAKYPRRMPCPGQPFLDAHPKKSKTEPFYQLNNPNDSDTVREATQSQRKLDEFDASDDVLVLTAHDSDAQGVIDLYPKTINEWKKPENDWKRKLHWAFLADFKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKG5</accession>
    <name>S0EKG5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434971.1">
        <property type="nucleotide sequence ID" value="XM_023582435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKG5"/>
    <dbReference type="GeneID" id="35406244"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12788"/>
    <dbReference type="HOGENOM" id="CLU_1643836_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="161" mass="18730" checksum="47772E0B7EE4036A" modified="2013-09-18" version="1">MQHSTISAGVDATRNYFQFRILSYFKSCRGSVLITSGLEILGRVLEAIVNANSTNSWRKIFIIVAGHISEELIRLSAEDERLYDQVQAQLPLHHEQSEEIGWAAIPRGILHERNKRRKALLGIQIRTTRIKTRRVLHHRALWYIHMLGCDRRMKVVGKYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM28</accession>
    <name>S0EM28_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to protein C21orf6 (GL011)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437698.1">
        <property type="nucleotide sequence ID" value="XM_023570610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM28"/>
    <dbReference type="STRING" id="1279085.S0EM28"/>
    <dbReference type="GeneID" id="35405145"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11684"/>
    <dbReference type="HOGENOM" id="CLU_064566_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF10">
        <property type="entry name" value="DUF1115 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G14750)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="1">
        <location>
            <begin position="172"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="297" mass="33262" checksum="FA93826B3DFD1F5A" modified="2013-09-18" version="1">MSSDEASQNALPKELMELQLGQIDLLMAMYASDEAIAMDFAASGLIETLRAWCESDREAAPKFSETVINLQLRVDVEDDDSTTRTLQLTLTVPLKCQIQEELTEPPPIKTRIQQPDWMSKGDVAKLNTEIPEEDILSVIEHIKDAASQHLLSLKQAEIANGPKADTSLVRVWFYFPSISTRAKRDDFINYAPTYGLTGFLLAGKPGILCLEGGSVAIDDFMKFIKTESWGDIPAHHKKVSERHREEATDLKRAFSDMQEITDMIEKRGARGNRGDMKALEAWLVECRLGEAFGKILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM38</accession>
    <name>S0EM38_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438144.1">
        <property type="nucleotide sequence ID" value="XM_023570825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM38"/>
    <dbReference type="STRING" id="1279085.S0EM38"/>
    <dbReference type="GeneID" id="35405338"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11878"/>
    <dbReference type="HOGENOM" id="CLU_011409_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT76098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57350" checksum="86F1A83465328A5B" modified="2013-09-18" version="1">MNPIRTSRAGKRSTRSRLGCRTCNTGRACDGYGVWDSKHPLPSTTKSPSQHMNPSCSVSRDRHTQLYFDWFVTRARKKIPGIFASEFWDTLVLQHSGECSPILTSGIGLCPQIGNALAGRHARKRELHIAALQRGHISVQHHLVTGNKESIRIVTISCLIFICLEFMRGNIKTGADHLQNGLNLLPLLNSPSCLGDGALVLKAHNESIEDVVTEAFLRLCVYSARFHRFPRNISIVTQDDALSGQSRSFPTLAVARLHLDELFNRIHRLEADARQLQALPCSITTTMLQNQRRIQKDLDCWLSLFKHSYEDIANNDSEESLPLTLLRIHHAMAYVMAGTCIAPSDELAYDLFKSSFDSVVSLSDHILEAAASVMAADIICGACTEKFSFSADMGIILPLYYTILKCRCPVTRRRALKVLLPVSHQEGIWNGPLAAAIACRVIQIEEEGYYGCSPIEDHPLESLIDAPIPTLPESHRISGVFIDPPESSTGDIIWGYRRAQENGQLAILQESVKAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMH6</accession>
    <name>S0EMH6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to 3-carboxy-cis,cis-muconate cycloisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438062.1">
        <property type="nucleotide sequence ID" value="XM_023571048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMH6"/>
    <dbReference type="STRING" id="1279085.S0EMH6"/>
    <dbReference type="GeneID" id="35405537"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12077"/>
    <dbReference type="HOGENOM" id="CLU_030949_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01597">
        <property type="entry name" value="pCLME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF2">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="2">
        <location>
            <begin position="368"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT76016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="454" mass="49622" checksum="548A9FD41AC0196E" modified="2013-09-18" version="1">MAAATVHDTSLFRDTFGTQEIRECFSERSYVSKLIEAECALAQAEEDQGVIPPGTAKVIREHSDVSKIDWPLLAKRAEVVGYPILGLVEQMASWVPHQQSGYIHWGATTQDIMDLASQLQIKSGIAIMERHLNETISILESMSSKYRDTPMAGRTHLQHALPITFGYKCGVWLSGLRRHAERLQQIKERCLLVQFGGAAGTLASLGSSDDGIRVRKRLAVILGLKDPVITWHVARDTIAEVVNFLALVGGSLGKIALDLMIMSSNELNEVAEPFVPHRGASSTMPQKRNPISSEIILAQSKILRAQAGLVLDGMVSDFERASGPWHLEWAALPVAFISVVGSLYQANFALSGLQVNSGAMKTNLESTRGLIVAEAVMMKLAQFIGRQEAHEVVYGACVAAIEGNLSLIESLQKIGQVTKHLSTDQLMSLVDPTQYLGCCQLMVDELLRLRASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI84</accession>
    <name>S0DI84_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to bZIP transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423951.1">
        <property type="nucleotide sequence ID" value="XM_023576517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI84"/>
    <dbReference type="GeneID" id="35395120"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01635"/>
    <dbReference type="HOGENOM" id="CLU_020925_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="592" mass="65064" checksum="46D7E4C2F14F236F" modified="2013-09-18" version="1">MASGPDTPGTVQSPAGFGPGPDDDSASLKRDADAVNPSSPAGGDDGAKRRKKAGPGSRGVANLTPEQLAKKRANDREAQRAIRERTKNQIEDLQRQIQELTNQQPYQELQSVLRAKEAVEQENADIKRRLAGIVAMLQPIIAGIEQAYVSPAQTYAPPVQHPVTLAVHNNHHNNANAASTPGSVASPPSHDTGPSQGHWHHQVHHAPPQHHHSPHPPTGPPNTAEAQAASQLTQQRRNLQHGLDMGPERLGLEFLLEPSQRVNRIQNGVNGAQDTPQFRHMPMKHDWTGVSQERALHSRSASWGSQGKPGQPSQEQQQGQHQPPSHHTLSAAHTPESSHSPGYSPAMSAAGGPVPRSEPSITDPATPIKNCPPTCPLDSLLLDFLSERRQRAADGLPAQDVVGPRYPSVSSLLNPANSAYSHPLSKVFTDILATFPDISTLPERVAVLYIMFLVMRWQIEPTQENYDRLPKWMAPCLSQLTIPHAAWLDHIPFPKMRDYLVRDHNPLLHPFDNFFVPFTTTLSLSWPYEETDTLLQDPDSDELMINPVFERHLRNLDNWKLGDAFAKAFPKLVGTFNLSQSTSPRPTSSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIB4</accession>
    <name>S0DIB4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424190.1">
        <property type="nucleotide sequence ID" value="XM_023579473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIB4"/>
    <dbReference type="GeneID" id="35394856"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01371"/>
    <dbReference type="HOGENOM" id="CLU_084512_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118:SF3">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494861" description="DUF7707 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="3">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="207" mass="21594" checksum="D27454F875707BEA" modified="2013-09-18" version="1">MRSSFALLAMAVSAVSAQAVQNYKSSLDMTIDPNTVDLATRSSWCGAQQNTCDALCKDDTNENKCTENDLKWECTCSSNSSTPGLQYYTQTMPTFICEELFSQCISQNTGSQSGQRECTSKIEDKCAKQNPPKDVVSDDDDGTSSTATDTATDTATTSATRASSESATGTAASVTSTSSDAFAAPTMAPAGRGAAAAVALGMLAYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIP1</accession>
    <name>S0DIP1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to nuclear localization protein NPL6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424186.1">
        <property type="nucleotide sequence ID" value="XM_023579428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIP1"/>
    <dbReference type="STRING" id="1279085.S0DIP1"/>
    <dbReference type="GeneID" id="35394860"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01375"/>
    <dbReference type="HOGENOM" id="CLU_013061_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF5">
        <property type="entry name" value="LOCALIZATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="549"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="633" mass="68556" checksum="99887AEBCF036179" modified="2013-09-18" version="1">MYSAQQPSADNATINPAALSSPVIGLTQQPQRTLKRSHSPGVYGAPQLGDDGDTKPLRKKARPMNKRSTGSISEAPGQAAGSTLPQTILPPQTPQSQGSALPQTSPAYTPQTQMPPKTTPTKSTLKALPTVRDHTTDQLNPTGDEYIPREIDEFGEKKVQLNGTLNGGREYKCRTFLVPNRGDKLFMLATECARVLGYRDSYLLFNKNRSLYKIIASQAEKDDLVGQEILPFSYRSRQIAIVTARSMFRQFGSRVIVNGRRVRDDYWETKARKQGFTEADLAGEKRPGATKAREAAEAQQNNVLLAGPHPEIVYSNNPGPFPGPPQPHLVQPGMIGPPPGTTTRMPGLTLGSDLSDSRPRDYSGILKGGPRQEITGPAYQDQTRPSPLGELNAQAHHAADFNRSVNQQRDMRNDYLQGVWRRPHEQPPSNLTQQPVASADSSNTATSRPSHSPHTTATAMSQQPGLVSTQSPQMMMTTAPYSQSISAQSSLSQAPMRGMAQSPTQSIRPTLPGTGGSMSQGAPGYNYQSGQMWPQTPQAPQHGYGSYTAQSQAPHPSQSPSHLRQGSSGQMQSMQFPGMAGMQYGAGQSMYPADQTPRQYMPQGGAGGPSVSQGWSGQHSPAQQWWTPGQQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJC2</accession>
    <name>S0DJC2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_01107</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424432.1">
        <property type="nucleotide sequence ID" value="XM_023582416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJC2"/>
    <dbReference type="STRING" id="1279085.S0DJC2"/>
    <dbReference type="GeneID" id="35394592"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01107"/>
    <dbReference type="HOGENOM" id="CLU_017900_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="376"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT62351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="564" mass="62832" checksum="2D03B723F98D3C76" modified="2013-09-18" version="1">MEASSPLAALHRPSMLPSWGSRDVFRGHPHYSTSSVTSASMSLREQMHKHSGDYFNVKDVRGSSPAASLAADLSQNFRLDSDSSPQFPTPRRALFTAGMMGSLEGRDSVTTPPLPSSSPAPLAELKELMEVSPLPHKTPFFTQFEITSPTPGSTPAADDEMILDSPAPISRQSSLEPPKPIMAENRRIAVPRRPSLTRMKGFSTTAVPSRQADTELPPFRFGAGSRLNHTSSNLSLSECFESTSPPQERRPASANSPCPGLSISRTRPQFLNFNACSRVNGSPSMSSHSRRQSNPFLRNRKQFRRSLSMFEHPADIMKSNSEGEETTSSALQSVMDVEEAQEPVLPHFLLEDPTDTIPRITRETLVDVLDGKYSSHFDQKIVIDCRFEYEYEGGHIDGAVNYNDKDLLTNQLFQTPMDGRTLLIFHCEYSAHRAPLMARHVRSEDRTVNAEFYPKLTYPEVYILDGGYSGFFTEHRGRCYPQEYVEMSDEAHQRTCEREMGRLKSRKGLSRAATFAFGQREPCVDESPTAPSRPQSRTLHAPISLLGASPIIGDRSHARRMASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJT0</accession>
    <name>S0DJT0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydrolase (HAD superfamily)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_01984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423618.1">
        <property type="nucleotide sequence ID" value="XM_023568418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJT0"/>
    <dbReference type="STRING" id="1279085.S0DJT0"/>
    <dbReference type="GeneID" id="35395467"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01984"/>
    <dbReference type="HOGENOM" id="CLU_045011_8_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051400">
        <property type="entry name" value="HAD-like_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470:SF2">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470">
        <property type="entry name" value="N-ACYLNEURAMINATE-9-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT61537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29326" checksum="3E6B02F39B23183A" modified="2013-09-18" version="1">MSLPPPDNLFTIESQPTRTMVFFDLDNTLFNHQQSTYYAMSAVRILLPLPREIPLDVLVDKYNEALDLVYNQYLRNEIAHEDQDSVKVKLFFKSLHLEEPDSKCIARFRSVYKRTYRGKRKAMPGSIETLRSLRKNGYRTAIITNGPTEIQIEKAKAIGVFDLVDCVITSQEAGHPKPDVRIFQYALEKLDVKPDDAHMVGDSVEADIKGALDAQISPILYSPGSNSSLKLLFGKEIPVIRQFDQLPMVLEPPLDSGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKY7</accession>
    <name>S0DKY7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425121.1">
        <property type="nucleotide sequence ID" value="XM_023573391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKY7"/>
    <dbReference type="STRING" id="1279085.S0DKY7"/>
    <dbReference type="GeneID" id="35393835"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00350"/>
    <dbReference type="HOGENOM" id="CLU_089370_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="231" mass="27159" checksum="81AAA228028CEA4A" modified="2013-09-18" version="1">MDRNSTQSITRGLTVSVASYLKQSGPPAEDSAQEARSAFPTRIRLDLPYFKHDIQAKWPTDERCRFERYRLTRFPSVNIGKRPWSEEELQWLGNEGINFDEMVERTTIRHDEEHPADAGIKTRKVVTILRGKHRAQWLKNPFQEHFDLDTRSCEAYACDRAFSFAQNGFVYQVWGDTQQFMCMYGYEYEVNDDCRIAAMQVKDIMREQWEDEDEDVCECEHDKCECVDGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLV7</accession>
    <name>S0DLV7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to calcium-related spray protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_01083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424453.1">
        <property type="nucleotide sequence ID" value="XM_023567886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLV7"/>
    <dbReference type="STRING" id="1279085.S0DLV7"/>
    <dbReference type="GeneID" id="35394568"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01083"/>
    <dbReference type="HOGENOM" id="CLU_013753_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF5">
        <property type="entry name" value="DUF907 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G06100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485062" evidence="9">
        <location>
            <begin position="27"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="28"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="667"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="729"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT62372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="767" mass="83684" checksum="38CBF68461DA9773" modified="2013-09-18" version="1">MTRLHSNWSVWKVAVTAATLVTGVLGDNILKTSGVADCGSEPGISIDKLDISYDNDKQTVTFDVAGTSDKQRNVSAILEVNAYGRKVYENSINPCSKDTPIPQLCPLPDKHFAAAGSQKIDSEWANKVPSIAFQVPDISAQATLRLVSVDNPEEQVACFQAQVGNGKTASVPAVTYLSVGVVGAALLVSGASAASSALSGTAGAGHGGAPSPSFAETLGWFQGMAMNGMLSVDYPPVYRSFVKNFGFSAGIIPWESLQKSIDNFRNMTGGDLTNDSFDVLRNATLVFSDNSTSPPEDHSYKVKRAFNTFESLANLAIRGVETSVGDASESEGGQSLKNQTLSVAGISAYVQQYSVPKSNTFMTVLLVVAIIIATIIVSILLVKAILEFWALFGSFPQSLSGFREHYWGSIARTITHLILVLYGIWVLYCVFQFTVGDSWVAQLLAGVTLAIFTAILGWFTWKIFSTVKKLKSTEGNADALYNDKEIWVKYSLFYESYKKDYWWIFIPTIVYLFAKGCTLAVGDGNGMAQTIAQLVVESIFLCLLVWTRPFERKSSNIIGIAIQSVRVLSVALILVFVHELKIPQDSKTIAGVVLIAVQSALTGLLVILIIWNAINVLVKENPHRKRRKEMEKAKRDMDTLTPLDARNSLLLDRKDNNSISMFAMPAPQEKVSGRSMSPDQYRDAESGYQQPPPNYLSSSPPMQRNLTNMEHNNDSQYLMDNAAPVAWTNRDPSPVGMGRYDSGDTGYSPLNKQQTYGYGNGGGYRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMD1</accession>
    <name>S0DMD1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="16">PE methyltransferase</shortName>
            <shortName evidence="16 17">PEAMT</shortName>
            <shortName evidence="16">PEMT</shortName>
            <ecNumber evidence="16 17">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_14418</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16 17">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16 17">Endoplasmic reticulum membrane</location>
            <topology evidence="16 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16 17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="16 17"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425865.1">
        <property type="nucleotide sequence ID" value="XM_023571582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMD1"/>
    <dbReference type="STRING" id="1279085.S0DMD1"/>
    <dbReference type="GeneID" id="35407866"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14418"/>
    <dbReference type="HOGENOM" id="CLU_005987_0_1_1"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000006">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 16 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13 16 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="561"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT63784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="971" mass="109763" checksum="46F887CC3B9451C2" modified="2013-09-18" version="1">MSTAADLPATGPGLRQRQSGVDPPAQQDKPQAEQGHSRQSSDVPFPSDKSSKTYGRTPDGTVFIVPTTHDMVSQLLDPRQPKNLSDAIVLTILGLHILAAYFLPSSSKRIVFAAIFLFWRACYNIGIGVLLQIQSNHRRLVTWARRWKLFENPSTGKNPRPWLYKLLKNELETKIPEDYEFEKAPIEYNTWLVFRRVVDLILMCDFVSYCLFAIVCGHTPEGENPLIGFSRWAVGIALIGFNLWVKLDAHRVVKDFAWYWGDFFYLIDQDLTFDGVFEMAPHPMYSIGYAGYYGISMMAASYEVLFISILAHLAQFAFLVIVENPHIEKTYNPPPPRKRTVSGGQSDAIPADMKSLEGAFDQQTLTPAQKDEPAPVHNLVGLSNLDLFRVPDFAVILMPFYVAVLTLVTPSTAVWQAAFVFHALAWRVWYHLGLGLILDQQSKNKMWTRHFLKFGESAGEAWRQWKGLHHISMIMCNTAFVAACWKMYSPPEDWAYGLVLLKHVLGASLVALQLWTAFSVYDSLGEFGWFCGDFFFDQQAKLTYKSIYRFLNNPDRFFGTAAVWGAALITWSRSIFLMALFTQILTVYYISYIERPHMQKIYGRSLRQEAGLTKFIKKSLPPPVKGWQESVDKVLDDTSQFVEDFIDTARPKFAAGVKTIVRDTSALFNMAPARLTITRIAPDLEGHDPKLYSLSVQGTPVNNAPIVEKYTGKESLTGRFPKPVKTMAFEYGAPLRVKWRAPANHSKKDWIGLYMVTDNRSRETTEVSSLGRWAPTNAGSYDALTADVSIVVEEHPVTSTEITETDLVEGEVVFEGDKLWWTQGVFEFRYHHNGHHHAMTISEPFEIRISKFDEEDVDLGAKGLYEQAVEAALLPVVQNCLDRDPDIAPNQPEEPFGGHVERDTKYAKRIVYAIREMFGIEFAPPVVAADGSVRKLAWRICNAKEVLAPYSMSLSRGTTTPAIQDFPSEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMK0</accession>
    <name>S0DMK0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424658.1">
        <property type="nucleotide sequence ID" value="XM_023570363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMK0"/>
    <dbReference type="GeneID" id="35394345"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00860"/>
    <dbReference type="HOGENOM" id="CLU_2184189_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="109" mass="12031" checksum="173235D78813D8E2" modified="2013-09-18" version="1">MLYIAVDNQWKTTSHRKHLEIQTLPVPLQTKQCLPNKDSTAVDRDDDRRSAVSELGTESSLKTWMNATAATNENPSQGLGLVTPNELKLDKGERKANEEGPGRVCNAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMP4</accession>
    <name>S0DMP4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425791.1">
        <property type="nucleotide sequence ID" value="XM_023571494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMP4"/>
    <dbReference type="GeneID" id="35398617"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05136"/>
    <dbReference type="HOGENOM" id="CLU_1049907_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28657" checksum="30CC56AAA386E906" modified="2013-09-18" version="1">MAQEDASLLGPRPSTAADRHTTKRPQLVPDSWSGVSPSFNYFIGLEPFAPSNQRNLSYIRGWVESFDTLSAIIVALPIGRITDHRGQQGVFMVVMAGILMSLTWSLIVRENSTTNALIGEVALINLILFFFTMPILLRIPVAALPGVTTTNSASLIAATTICGLGFGARSTQLSPVTSWIDPQRAGPLFSAVFLVEHIGMLGGEPLVQNELGVSLGLQDPWKGLPLIRTAKVCEKSYNFKLLSSEPLGTTSTITTGELIRFFVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMY4</accession>
    <name>S0DMY4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to TFIID and SAGA subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_00679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424818.1">
        <property type="nucleotide sequence ID" value="XM_023572374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMY4"/>
    <dbReference type="STRING" id="1279085.S0DMY4"/>
    <dbReference type="GeneID" id="35394164"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00679"/>
    <dbReference type="HOGENOM" id="CLU_068315_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000069">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="253" mass="26314" checksum="4A8F2C2E1C4A5775" modified="2013-09-18" version="1">MSSSQPQTNGVPASSAGTSQPLPSTQTTAASSSQPAAAASQNAPPPAQSTTAPRPRDSRLIELLLTSQGVTAYEPRVPLLLLDFAYRHTSSVLSDALHLSGDPYVTQAGSKPSANAGAISAPAGDAAVTANAVKLAIAARLSYQFRGGNAGGGISKDYMQELARERNKVALPKIVPSEWGVRLPSERFVLSGTSWGLKDVWDEEDDEEEDQGGDAMEGIEGPEPEDIGGDGVEGGTVEDMFGEDVDEEMAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN49</accession>
    <name>S0DN49_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable pyrimidine 5`-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_04968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425946.1">
        <property type="nucleotide sequence ID" value="XM_023571682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN49"/>
    <dbReference type="STRING" id="1279085.S0DN49"/>
    <dbReference type="GeneID" id="35398449"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04968"/>
    <dbReference type="HOGENOM" id="CLU_059493_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.450:FF:000001">
        <property type="entry name" value="SDT1p Pyrimidine nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="237" mass="27316" checksum="B568EF46A61B5958" modified="2013-09-18" version="1">MGSTQDMNPGKPVLFFDIDNCLYPRSTKVHDIMAKLIDEYFSKHLEIPWDEAVKLHKEYYTNYGLAIEGLVRHHQIDPLDYNAKVDDALPLEEIIKPNPELRELLEDIDKSKVTVWLFTNAYVNHGKKVVRLLGIEDIFDGLTYCNYAEQPLLCKPDPRMYEKAMREAGVDRVEDCYFVDDSALNCTEAKKFGWTAAHLVEEGVPAPKTPASQYQIQHLRELRNVYPQFFKSTSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNE5</accession>
    <name>S0DNE5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to fungal transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426042.1">
        <property type="nucleotide sequence ID" value="XM_023571798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNE5"/>
    <dbReference type="STRING" id="1279085.S0DNE5"/>
    <dbReference type="GeneID" id="35398346"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04865"/>
    <dbReference type="HOGENOM" id="CLU_020030_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF51">
        <property type="entry name" value="ACRIFLAVINE SENSITIVITY CONTROL PROTEIN ACR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="570" mass="63882" checksum="9EA10847B21416FF" modified="2013-09-18" version="1">MPPSNTKPCHNCRRRRLRCDRSWPTCHKCAVSGQECLGYGKVFVWTQGIDSHGNVNPPPGRRLPDESDASTSVSPPGHQQGQGQHDRARPQPQPDYSDQHPLARLVQQAQQAAQEAEEMNQHQQQQRQQQQPTPPGSEDAPSHDPSIPWPSPAALTDPLFQDLDRTSRYYLAHFSERVCKDLVVRDTPENPFRELIPLTRKHPLLLQILVATSAIHWSNIFRRVTEIPAGLTNPAGYLSLLRSKDLVTRQALIDALTAKQKAMSHMREVLDTLDPAGSEVALAAMHFFIKFDLIDLDKSDNQSWRAHLEGATSIMALLNPDSNPDASSRMLRDRVITDSFIYNILGSTLTSGGLAARVARQAFQFLPVMKRVELTSYLSCPPEILNIILSASELSHEVPWTDQSLGAADKAIALIDEALAVDIPAWADYLRQHNLVQDLESRVCLAAAHRSAACLYILQALPLVRSVRSIDTDFLLEDVLRNLAAIDENDPYFKASSWPTFVAGAETRDPEKRTWTLARLLSIWQICPWGYLFTAIEMLKATWAMQDSRGSDNVNWLHDLRGMGFENLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNH8</accession>
    <name>S0DNH8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">FFUJ_04839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNH8"/>
    <dbReference type="STRING" id="1279085.S0DNH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04839"/>
    <dbReference type="HOGENOM" id="CLU_057381_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT63986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="346" mass="38747" checksum="A5E1C7ECDA3D82D6" modified="2013-09-18" version="1">MDKYIDGRFERLEKALANLIDSVTKYHPSIQQGEELNAADQELSRGLEEVQTHQNNYLRIQQLRESSNALDTQIRDTLSNLATTRKDIVTTQTTTFPSGPSYPIAYAELLNYARRISKTTMPPAGTIKAVPQTADVPEVQTPGGQTPAAQTPGPESQAASVMTPSAPPSSQVQSPAIMNGTPAVSQEPATQQSSMSANTVLPSEWTQFLNPLTDQIFLPWPNDLQLGAGSLAANQLLQEQGIDPKGYDPAEEEERKRREEEERKQKEEEDRIAQEEREKKQREERERQRIERERQREKDQEAWRRASLVGGPAAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNI2</accession>
    <name>S0DNI2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to ribonuclease H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_01355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424204.1">
        <property type="nucleotide sequence ID" value="XM_023579650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNI2"/>
    <dbReference type="STRING" id="1279085.S0DNI2"/>
    <dbReference type="GeneID" id="35394840"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01355"/>
    <dbReference type="HOGENOM" id="CLU_008679_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="333"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT62123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="716" mass="79138" checksum="70315C2008DB8713" modified="2013-09-18" version="1">MGKKAKRKAAKLVNKALTALEYDPIPEAVDQASSSDNQDEAQTSDKFDQGVPVTTAIATLEKDVSTQSDGSLKRSNPHDADDGGEWQVVSRAAKKLKKVPKPGKNYPTIAFSPNARLQSKINISQMRDLVTYIFADGAGPQWIGITHRPAFRKIVAIMIPGIEEAMFKHNVDFDTYNDADRERNAAVTSPDDYYPRPLKRERLPKALQPFADMFTHLWPVKTPGDDRHGKMHSPLAAFLTTPTPKEKNGPKGIKPAHEPSGWKNERTRITEFLCTVDDLTDNGYLVHPAMLEGVARDQFVLPEGWVITHVKSLEEGQVPEDEVEKGSITQGRDILALDCEMCMTGEDEFSLTRISIVDWFGNVVLDELVKPDKPITDYVTQFSGITEEMLAPVTTTLHDIQQKLLELLTPRTILIGHSLESDTKALRITHPFIIDTSIIYPHPRGPPLKSSLKWLAQKYLSKEIQKGGANGHDSIEDSKTCLDLVKQKCEKGKAWGTSDSQGENLFRRLARAGTAYKAQGGAAGGAEVGKTSAAVDWGDPSKGAGAGATHQLGCKNDEDVANSVIRAVQGDPDGLEIRGGGVDFVWARMREIEALQGWWNRNRADNINSDGGPPEDPEAVPSDKSELERALVRLTERLTRIYDALPPCTAFMLYSGSGDPREMSRLQKVQTQWRKEYNTPGKNWNDLSVKWTDVEEQALKEAARKARSGIGFISVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNR5</accession>
    <name>S0DNR5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to NAM9-mitochondrial ribosomal protein, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426315.1">
        <property type="nucleotide sequence ID" value="XM_023572131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNR5"/>
    <dbReference type="STRING" id="1279085.S0DNR5"/>
    <dbReference type="GeneID" id="35398049"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04568"/>
    <dbReference type="HOGENOM" id="CLU_026386_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="162"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="528" mass="60052" checksum="47351536EFFA0377" modified="2013-09-18" version="1">MRRPTKYYSLTRPKLRQSWNKYNLFNIARAAGREPQVNSRATFFQQKWAAKSKTRGYHGEHVSEKKWVRLFSRRLQSAVDLPPEYLAANDGAEQAAGRGSGLTTSNVTAETYSRVPKGSTTVRSPSHPAQRGRAFGNVNDMLSEHFQNMTPYMQMTFAPLERRLDTAVFRAMFASSVRQARQFIIHGAVKVNGKKMVHPSYALNPGDMFQVEVEKVLYGTGEQKTAEYTTMESREKEMLDQQEESVRKHGLKKQSKVLDAVAKEGEEAESADAKALGKNARRRVEREVQLHRVKNLRTTAREILKGDMRNLSAKQKKDLRLFRDTAQRFLSLPEARELDARDLLHQIQAQITKLESVDTFRKADSTLAKAANAEASAEASAEESAEPQTEKSVSKLSKEEREAKKLQFKNNVLEKGLEGITNKADRDRAMNILATENLTHEETRRLINILRNDSENPIDPSKPYVTPWRPRPFMSAFAFIPRYLEVNPNICAAVYLRHPVARKGMAEVPTPFSYLTNQLAHNWYLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNZ9</accession>
    <name>S0DNZ9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase F0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426390.1">
        <property type="nucleotide sequence ID" value="XM_023572227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNZ9"/>
    <dbReference type="STRING" id="1279085.S0DNZ9"/>
    <dbReference type="GeneID" id="35397963"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04482"/>
    <dbReference type="HOGENOM" id="CLU_061220_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32929" checksum="B0E7E993C5D12540" modified="2013-09-18" version="1">MANWQQYNPFGKRESHSSSAILTYKILTLVTWILSLVVTVYYTLNRPDDGHTRNRKIWEQNHMYRTAFTLNPIITSIYWVVLFILQAGYIGHLFSSNSDIVHAAASVGSHFIFNNLFHFAFVMLFVRSHFHWAEVVLVLNFINLSSLYFRHNTYPRFIHTPVVSGPLAWTFVAIYWNGALMVPHPDHLVARIFGNIFIWSILVYGLFFVTIYKDYTMGFSLSVFAAAIGVSQFLHQVIAFQWIFAFVIMALLFIATVVVAVPAATGREINWRSAPADQERAPLLAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPM0</accession>
    <name>S0DPM0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to protein LAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_04274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426580.1">
        <property type="nucleotide sequence ID" value="XM_023572460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPM0"/>
    <dbReference type="STRING" id="1279085.S0DPM0"/>
    <dbReference type="GeneID" id="35397755"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04274"/>
    <dbReference type="HOGENOM" id="CLU_028277_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="199"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT64499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="520" mass="59733" checksum="A736E57EAF22C97A" modified="2013-09-18" version="1">MSDHPVMQVEDKIVPGPSVASNETAVEETVVRQDVTVITTTDEATGPNSALSSTTNPTSATTAAPRPRLKKDNSTPNMNGPLYMQTAGNKTVLVRRLKRKEESTWKHLSRWFVENQIGLSFNLLALIFLAQTFIPKAREHTHKFFHLSYYSSQSGQYRIGYDDAYFITFCVILFTGLRAATMEYVLAPIGRLQGISNRKNLTRFSEQAWLMVYYTVFWPWGVYIYCTSPHYMSMENLWTDWPNRELDGLMKAYLLCQWAFWLQQMIVINIEERRKDHWQMFTHHIVTTALIFACYTYHHTRVGNFILVIMDVVDLFLPLAKCLKYCGFKKVCDVMFGLFVVSWFIARHVLYIAVCWSIYSDTPRIMPTGCFKGNNEDMVGPIDPPAGWKYLVDPFINPEGLVCYNETIKWSFLAPLLFLQVITIGWFTMIVRVIIKVLKGGDAEDVRSDDEGGEEEEEEEFVYEEAQPLEEEVGVEELDLRNWERRSGVKKQASSSGVSLPGHSDRKELLGRIGCEKQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ16</accession>
    <name>S0DQ16_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable UBC8-E2 ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426740.1">
        <property type="nucleotide sequence ID" value="XM_023572657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ16"/>
    <dbReference type="STRING" id="1279085.S0DQ16"/>
    <dbReference type="GeneID" id="35397579"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04098"/>
    <dbReference type="HOGENOM" id="CLU_030988_7_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010637">
        <property type="term" value="P:negative regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="203" mass="22704" checksum="39F59EC12D95F45A" modified="2013-09-18" version="1">MSSPRRRIETDCKLSIPLSPTPIYSLTDPLRQEFFVRFKGPAETPFEGGMWKVHVELPDTYPYKSPSIGFVNRIFHPNIDELSGSVCLDVINQTWSPMFDMINIFEVFLPQLLRYPNPTDPLNGEAAALLIREPKSYDAKVKGACAWVLESDIILMTAEYVQKYASKDAADEAGAESEDDDELSSVASFGDDDEEPAGQMDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQT0</accession>
    <name>S0DQT0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to hippurate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_03955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426872.1">
        <property type="nucleotide sequence ID" value="XM_023572815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQT0"/>
    <dbReference type="STRING" id="1279085.S0DQT0"/>
    <dbReference type="GeneID" id="35397436"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03955"/>
    <dbReference type="HOGENOM" id="CLU_023257_6_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="5">
        <location>
            <begin position="206"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT64791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="431" mass="46363" checksum="E8DC708BC411F721" modified="2013-09-18" version="1">MSKSILSDLVDQHRPDLQPLEELYKHLHRNPELSNQEVETAATIAQRLREISPEDLVIKPHIGGHGLAAVLRNGDGPTVLLRADIDALPVQETTGLEYASTKRMIHAASGVEKPVMHACGHDMHIVTLLGAAATLFSSRESWAGTLVLAFQPAEERGTGAQAMVDDGLYTKHEVPIPDFVLGAHVRPLRAGTIGTRRGLVATSADNYKVTIHGKGSHASMPHTAIDPIAISANAILKLQTLVSREVDPAESSVVTVTSIHAGDAENVIADSAVLGVDTRSTTIATRERLLKRIKAVIEAECACANVLKSPDFEQTRAFPLTINDEAVTKRVEESFAAHFGEGPGKYDRDMPKLAFSEDFSILATAVDKPYCFFTYGCVDGDVWDKAEKEGTVAQSIAANHSSKFAPIIQPTLRTGLDGYALGALTFLAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQV6</accession>
    <name>S0DQV6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to monooxigenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_03906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426916.1">
        <property type="nucleotide sequence ID" value="XM_023572870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQV6"/>
    <dbReference type="STRING" id="1279085.S0DQV6"/>
    <dbReference type="GeneID" id="35397387"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03906"/>
    <dbReference type="HOGENOM" id="CLU_006937_8_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT64835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="535" mass="61265" checksum="E7D9E4750A5DD2CE" modified="2013-09-18" version="1">MTVNTIVLDALIVGGGFGGVYQLKRLREEGYNVKLVDVASDYAGVWFWNRYPGARVDSAIPHYEFSDPELWRDWNWTQRFPGSAELREYFSYVAKRWDLRKDTFFNTYISKAVWNEETSKWEIESKDGKKFVARYLLLNTGFAAKRHTPNWKGIDKFNGLWVHPSYWPEKEPDLQGKKIAVIGTGSTGVQLAQELSQVASEFVLFQRTPNMALPMKQIEYSRNDNAISEERYREVYSGRHESYGGFDFNSYPRDTFSDDAETRRAKYEELWTHGDFKFWLANYQDMLAREDANAEAYKFWKSKVRSRVKDPRLQEILAPEKQPYSFGCKRISLENGFYEIFNQPNVSLVDVNATPVVEVTERGIKTTEKEWEFDVVVCATGFDAITGGLKDINISGVSGVKLADKWETGAKTYLGMAVAGFPNMFFTYGPQAPTALCNGPTCAESQGEFIVRVMKYMSTQGRHKIEAREDAEAEWGDKVREFANASLFPKTKSWYMGDNIPGKPRECLIYLGGVPTYTKTLEDCTENGLEGFQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR93</accession>
    <name>S0DR93_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to HOL1 protein (Member of major facilitator superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_03755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427057.1">
        <property type="nucleotide sequence ID" value="XM_023573037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR93"/>
    <dbReference type="STRING" id="1279085.S0DR93"/>
    <dbReference type="GeneID" id="35397236"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03755"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT64976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="546" mass="59775" checksum="543CF9DE02AC002F" modified="2013-09-18" version="1">MSIDIRKTDTGTADGRNDMLGGLRLRNEETNEIILIPTPTNDPNDPLNWSKPYRFYIAVLVSCAIFFSNFLAAGPSVAIVSTTESFFGPPGPDFSAQVSKIAYFFTTTALLQGMGNLIWMPFVAKFGRRPTYVTSFILYTAVAAWAGGATTYGSALAARILMGFASGVAECLAPLTISDLFFLHERGAAMAIYTTALSAGVGAGIIVAGLITINLSWRYIYWVSVALIGVCTILIIFTFPETVYNRQEVTEGTHTHIVTNRKDQDEDIEKVQFDEASASGHVSNAPAQKRTFWQNMSLYSGTHTKESLLKLFFRPVVLLTLPPVLWATLVMSVTIGFLVAISSNFAVAFSATYGFKPWQSGLCFISCPIGAGVGAFFGGHFSDKVADRLTRKNGGIREPEMRLPAILISLVVAPLSLVLYGVGIDRNWHWIVPTLGLGLLNMAIVQATNVSLVYTIDSYRPVAGELAVTQLAFKSAFGFLLSFYTNPWIDKSGYANAFGAMAGISGAVILCWVPIYIWGRRIRHATWSWGYIEKFVHWNVDREVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRK2</accession>
    <name>S0DRK2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_05153</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10841"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427141.1">
        <property type="nucleotide sequence ID" value="XM_023571476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRK2"/>
    <dbReference type="STRING" id="1279085.S0DRK2"/>
    <dbReference type="GeneID" id="35398634"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05153"/>
    <dbReference type="HOGENOM" id="CLU_015170_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000046">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="97"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT65060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="540" mass="59962" checksum="683839D3E9A20BC5" modified="2013-09-18" version="1">MATDSTHTQSQVYLSTRGGDYGLSFETVVLKGLAADGGLFSPMRFPLRQNGCQSWKDLSYQELAFQIFSLYISRSEIPAEDLQGIINRSYSTFRAQEVTPLVQLKDNLHLLELFHGPSYSFKDCALQFLGNLFEYLLARKNEGKEGKDRHHLTVVGATSGDTGSAAIHGLRGKKDVSVTILHPKGRVSPIQELQMTTCTDANVHNLAVTGTFDDCQDIVKALFGDPETNASLKLGAVNSINFSRILAQIVYYFYSYFSLAKKSSTFKVGDKVRFVVPTGNFGDILAGYFATRMGLPVDKLVIATNENDILDRFWKSGKYEKQPARGPEAQGGLEVDGVKAHEEGVKETLSPAMDILVSSNFERLLWFLAYEFAATVGMDVEFNRKQAGQEVATWLKDLKVKGGFGPVYVDVLNSARKTFESERVSDPETLETIKSIYEQFSYVLDPHSSIGVTASLRSAQRAEANLPHISLCTAHPAKFAGAVELALKDEKDFNFQEKVLPEEFVGLEKLPKRVSDVSNDWKAVRELVKEQVEKELSGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS62</accession>
    <name>S0DS62_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_01413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425489.1">
        <property type="nucleotide sequence ID" value="XM_023578994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS62"/>
    <dbReference type="STRING" id="1279085.S0DS62"/>
    <dbReference type="GeneID" id="35394898"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01413"/>
    <dbReference type="HOGENOM" id="CLU_085878_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990328">
        <property type="term" value="C:RPB4-RPB7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT63408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="172" mass="19121" checksum="C3E69FCC6B72E073" modified="2013-09-18" version="1">MFFLYNLERKVTLHPSFMGRNMHDLVTAKLLKDVEGTCAGSYFIISIMDAFEISEGRILPGLGMAEFTVGYRAVVWRPFKGETVDAVVHSINPQGFFAHAGPLQLFVSAHLIPSDVKYDPNATPPQFTNNEDTSIEPQTHVRVKIIGTRTEVGEMWAIGSIKEDYLGCLQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSJ4</accession>
    <name>S0DSJ4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_02365</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427507.1">
        <property type="nucleotide sequence ID" value="XM_023574086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSJ4"/>
    <dbReference type="STRING" id="1279085.S0DSJ4"/>
    <dbReference type="GeneID" id="35395847"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02365"/>
    <dbReference type="HOGENOM" id="CLU_029631_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT65426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="501" mass="54558" checksum="16047D4C02858B30" modified="2013-09-18" version="1">MRPPRCLLPAAEKILLNAAAPASRRCMSSAAALQPPRILAAAPWKGSSFFLSNRLFDRSTCLDFVILRRANGIRSTSASAATISSTNTAQTEPEQELAPHRRRQAQRREKAAADAAAAAARGEKPLPPDASSLLASHAASQTSSFRRYLSACLSLSKPRLTMLVVLTGMATYALYPVPEMLSPSTTETPSLSPLTLLFLTIGTTLCSSSANALNMLYEASTDAKMTRTRNRPLVRKLISQRAAVLFAVLAGALGTGALYFGVNPTVSGLGFANIVIYAGMYTPLKAVTVFNTWIGAVVGGIPPLMGWAAAAGETATKDGSWRELLFSPDGSSIGGWVMAGLLFAWQFPHFMALSWPIREEYKKAGLRMLAWTNPARNGRVALRYSFIFIPLCVSLCAAGVTEWSFAVTSLPINGWLIKEAVRFWRFEGHQGSARSLFWASVWHLPGIMILALLHKKGMWSRVWRSVFGEEEGEWEEEELDEMISMAAESTNGQSQHDKPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTJ6</accession>
    <name>S0DTJ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable MET12-methylenetetrahydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_02716</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427826.1">
        <property type="nucleotide sequence ID" value="XM_023574481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTJ6"/>
    <dbReference type="STRING" id="1279085.S0DTJ6"/>
    <dbReference type="GeneID" id="35396198"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02716"/>
    <dbReference type="HOGENOM" id="CLU_025841_2_1_1"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="410"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT65745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="673" mass="75090" checksum="5F403F5DF845B45D" modified="2013-09-18" version="1">MDKITDRIAALPADGTYFSLEFFPPKTAMGFSNLRDRLHRMERALRPLFVNVTWGAGGSTSQKSLELAELCQREVGLTTCLHLTCTNMSKKLIDEALSDAKALGIRNILALRGDPPRREEYRDPEDSEDDGGQDFNWAIDLVRYIRKTHGDYFCIGVAAYPEGHAEESHPLGQSLEHDLPYLVQKVQAGADFIQTQLFFDIEAYEHFETTLREHPSGAFKGIPIIPGLMPIQSYQMIKRTTKLSHAKIPDHLLARLDAVKGDDERVKMVGVDIVSELIDKIKDIKSKTPGPKGFHFYTLNLEKAVSFILERANLIPDPPENEEAIAVDELAIPSLQINGSANMRSSSHSRSRQSRRHSSVASDPHNRVIVGDRPAIYPEWEATGQEAGVRAEAINTRANTLAISEGEGVLGREATWDDFPNGRFGDARSPAYGEIDGYGVSLHMSVTQAVKLWGYPKTRQDINDLFVKHIQGELSAIPWSEEELRAESSTIQPNLLQLNRKGWWTVASQPAVNGLRSSDGTFGWGPPNGFVFQKSFVEFFIPANEWDTLKAKLTSPELQDSVCFYASNARGDYLSSDNSDHVNGSTEAGPSTNAVTWGVFPGKEIITPTIIEEVSFRAWSEEAFGIWGEWAKVYGRGSESEKLLSGIKDDYWLVNVIHHDFVERDALWQLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU61</accession>
    <name>S0DU61_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428195.1">
        <property type="nucleotide sequence ID" value="XM_023574922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU61"/>
    <dbReference type="STRING" id="1279085.S0DU61"/>
    <dbReference type="GeneID" id="35396593"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03111"/>
    <dbReference type="HOGENOM" id="CLU_046160_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="162"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="162"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="269" mass="29794" checksum="2C128FA4B80C44C0" modified="2013-09-18" version="1">MTITLKRKASEADLPPRTPAIPSTLPPSVEEAYRRKCVQLKNRTNEVEDANDAARLRLARIKRQVEKLRIERAFLLEQLAKRTSANVEDSDGSPSPPPTPKDKPLRTKRGHRKSMMPDSDSKAPVAASFTNTAGSPTSETFSHPPESQPKPAHANGISASDSKKPTSAFELFCSETRPGLESKEKDSEIPLNIEDELARVWKGLSDGEKDEYEARFELAMAKNDESKKSPASDKKDDKPAEPKQLVQDEDIEMGDDTEDQDTQAGEKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU65</accession>
    <name>S0DU65_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426159.1">
        <property type="nucleotide sequence ID" value="XM_023571936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU65"/>
    <dbReference type="STRING" id="1279085.S0DU65"/>
    <dbReference type="GeneID" id="35398222"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04741"/>
    <dbReference type="HOGENOM" id="CLU_089876_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="4">
        <location>
            <begin position="79"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT64078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="177" mass="19697" checksum="96142D559860FF7B" modified="2013-09-18" version="1">MSDNKPTDNHRKTLKEGSPEERVKTWLQLSQNDNGHSKQGDWINTLIPHLQLVSTNAEGPHPSCVFSYTVQPDNCNRLQNLHGGCAATLFDWCTTLPLALVNKPGFWQHMGVSRTLNVTYMRPVPVGTEVLIECSITQVGKKLASLHGSMRRRSDNLLLATAEHGKVNIDSDIKAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV09</accession>
    <name>S0DV09_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to C6 zink-finger protein PRO1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_02156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427308.1">
        <property type="nucleotide sequence ID" value="XM_023573854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV09"/>
    <dbReference type="STRING" id="1279085.S0DV09"/>
    <dbReference type="GeneID" id="35395638"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02156"/>
    <dbReference type="HOGENOM" id="CLU_019313_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF26">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT65227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="567" mass="62775" checksum="B6874013511117DD" modified="2013-09-18" version="1">MRSSPSGCWTCKLRHRKCDLQIPACRECTDRRLPCHGYGPKPAWMDGSAAEHQDLERIKKAVKQYLKKLRRGQQNKSLGRDAAVGSSTERRTRVQAPSAPGVTDLSSPSSPQTALHLAYDNFESPETLADASSSLTVTRSSFQDSEAVQPVLTSQNPTPSCVLFPRLAFLIMYYLDHVFIWQFTYYQFKSSLGNRGWLLTCLSNGGSLSHAALALSTLHRDVSQKRCYYSQEAFEFHSMALRELRNLSQHTETETLLNDRAKFSEFIAASLTLISFEVFNGAEYDWVPHLDAVTAVLAMYSPGALLRTSSLSENDLPSPINISADDDPELQGDFNFLVAEALWHDILACATTGRVPRIPYRQWLEGSSIVMADLMGCYNWVMIAIGDLAHLNAWKKDMEQKGTLSVPELVRRGQKIEKELQDGITELKRAAKAGGDIRGNVSPAPYVSHIFALASLVLSSTIISGPWASLPEVKDAVSESVIVLRNWPQSVPLRGLVWPLYIIGSMAEASLQGVFESLLYRIREESGGFGNSGTVIKLLKGRWAAPPIRNDDGLEMVFETGGNVLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVZ8</accession>
    <name>S0DVZ8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartokinase</fullName>
            <ecNumber evidence="10">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_02498</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="10"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427628.1">
        <property type="nucleotide sequence ID" value="XM_023574236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVZ8"/>
    <dbReference type="STRING" id="1279085.S0DVZ8"/>
    <dbReference type="GeneID" id="35395980"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02498"/>
    <dbReference type="HOGENOM" id="CLU_009116_6_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="448"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT65547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="511" mass="55823" checksum="CFD938F35B85526B" modified="2013-09-18" version="1">MGSLSHCNSPSLGWVVQKFGGTSVGKFPDKIATDIVRASLSQNRVIVVCSARSTGKKAEGTTSRLLAVYGKLRGVGAAMCVDEEQQNELVEQARGLMLDICNDHVFAAEAYIQDPSIRGKLIQTIKDECQELVEYIVAAKRFNLEINSRAKDRVISFGEKLSCRFMAALLQDKGVESEYVDLCDSFHYDASERLDDKFYRTASEAFTRKIAACESRVPVVTGFFGNVPGSLIDGDIGRGYTDLCAALCAVGVKAEELQVWKEVDGIFSADPSKVPTARLLSSITPSEAAELTFYGSEVIHHLTMDQVIRAEPPIPIRIKNVKNPRGNGTIVVPDRILSASHQLTRDSPKPQVEHKKPKRPTAVTIKDHISVINVHSNKRSISHGFFARVFSILDTYSISVDLISTSEVHVSMAIHSSSQQVEAFGKATKELAECGDVSVLNDMAILSLVGAEMKNMVGIAGRMFSTLGEHNVNLEMISQGASEINISCVISARDATRAMNVLHTHLFTFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWH8</accession>
    <name>S0DWH8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_02723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427833.1">
        <property type="nucleotide sequence ID" value="XM_023574489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWH8"/>
    <dbReference type="STRING" id="1279085.S0DWH8"/>
    <dbReference type="GeneID" id="35396205"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02723"/>
    <dbReference type="HOGENOM" id="CLU_035254_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="187"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT65752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="445" mass="50673" checksum="2FDABC05545519C9" modified="2013-09-18" version="1">MAETKTAGQPTLVFVDGSFEDLAAEMADYLKAEDAKQLLSQEKPPSQEEVISKLVSASGALNTVPEKEYTAASNLMTHLVLMSSDPKKFLPTLCTTFAKPLLNSPVHGAGLSLNALTTVFNLLDPTDPVRARVFMEILKFLRAHGMFESLRTYLDKLPEWLATWGTDADFQRKIYEEVAEVAIEAGEEQQAYEYVVKALRTFDGDAISSEEAQRLSLRAVKKALTSNNHFLFQDLRGIPSVQALSDSHPVYSQLLDIFAEQDLEDYNDFNDEHQGWVEKEKLDHEKLHRKMRLLTFSSLAASTPSREIEYSKITKALQIPENEIEMWAIDVIRAGLVEGKLSQQRQKFLVHKVTYRVFGQKQYQELANRVDHWRTTLQNVLGVLRQEQANAKAQKEREIQELERKVANAGVSGNQDGGRRRQNQNREPREPREPREPRERTEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWP7</accession>
    <name>S0DWP7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_13090</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429002.1">
        <property type="nucleotide sequence ID" value="XM_023575734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWP7"/>
    <dbReference type="STRING" id="1279085.S0DWP7"/>
    <dbReference type="GeneID" id="35406546"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13090"/>
    <dbReference type="HOGENOM" id="CLU_009165_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000020">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="15">
        <location>
            <begin position="480"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT66921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1004" mass="111969" checksum="4204D3375619FB0A" modified="2013-09-18" version="1">MLRNAAAGARKAVTELSQFPKPGEKLHGFTLVRSKHVPELELTALHLQHDKTGADYLHIARDDSNNVFSIGFKTNPPDDTGIPHILEHTTLCGSEKYPIRDPFFKMLPRTLSNFMNAFTASDHTFYPFATTNAQDFKNLMSVYLDSTLHPLLKKSDFTQEGWRIGPENPLAEDEASKKLVFKGVVYNEMKGQMSDAGYLYYIRFHDHIFPDINNSGGDPQKITDLTYEQLRKFHAEHYHPSNAKVFTYGDMPLVDHLQQVDAQLQAFEKIQGDKQIHEPVTLSGPKEVTLYGPLDPLVDPDRQYKTSVSWIMGDTTDVLESFSLALLSTLLMDGYGSPLYRGLVEAGMGADWSPNAGYDSSAKKGIFSIGLTGVQEADVPKLKEKVQQILREVREKGFDKTKIDGSLHQLELSLKHKTANFGFSMLNRLKPKWFNGVDPFDSLAWNDTINGFQAKMAEGNYLEGLIDKYLLNDNTLTFTMAPSTTYGEDLVKEEQERLSTRIQAAIKEAGSEENARKHFEKQEQELLVEQNKTNTEDLGCLPTVHVKDIPRSKEPVVVRDENANGTKIQWHEAPTNGLTYFRAINTLENLPDELRELVPLFTDSIMRLGTKDLNMEQLEDLIKLKTGGVSVGYHCTPSPTDFHAASEGLIFTGMALDRNVPVMFDIIQKLVLGTDFDSPEAALRVRQLLQASADGVVNDIASTGHRFAMGSAESGLTRSSWLRQQVSGLSQVQLVTSLASRPETDKLEDVISKLKQIQSIALAGGNLRTAITCGPESVAENGASLQKFVGNLSRDPLDLKNPSPRQLPKDSKTFYPLPYQVYYGGLSVPTTSYTAAEGAPLQILSQLLTHKHLHHEIREKGGAYGGGAYSRPLDGLFGFYSYRDPNPQNTLSIMRGAGQWAVNKEWSDRDLEEAKISVFQGVDAPKSVNQEGMGQFLSGITEEMKQKKREQLLDVTKDQVREVAQRYLVDGLAKGEGRVAFLGEKQPWVDGEWKIREMDVKGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWS6</accession>
    <name>S0DWS6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429032.1">
        <property type="nucleotide sequence ID" value="XM_023575773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWS6"/>
    <dbReference type="STRING" id="1279085.S0DWS6"/>
    <dbReference type="GeneID" id="35406580"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13126"/>
    <dbReference type="HOGENOM" id="CLU_060131_6_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="218" mass="24693" checksum="E279DC96144EE739" modified="2013-09-18" version="1">MPFQLRPAVPEDIPEMCQVYYSAFGDTSIGSRVFTSDIEASDRFFQKTFTDDIADPLCELLVVTHKSSPDSKDEKVVSLAKWALPGAPIQDPPPAEAWPANGDLAVEFFGAMTRGHRGLMGDRPHYYLEVICTHETWQRKGAGTLLLRWGIERADTDGLPCFLEATPKGKLVYEKLGFRVKAEEEFKWSFGTFVETYMERDAKIEKRTMTRPKSKEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWX1</accession>
    <name>S0DWX1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429082.1">
        <property type="nucleotide sequence ID" value="XM_023575831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWX1"/>
    <dbReference type="STRING" id="1279085.S0DWX1"/>
    <dbReference type="GeneID" id="35406632"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13178"/>
    <dbReference type="HOGENOM" id="CLU_045276_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="150" mass="16568" checksum="FCEC275E1B758C0E" modified="2013-09-18" version="1">MAARRAVQSILPKSQPPAWTASKRITEFIAHVTPVTSPSQANIYLESLLESDKRIRNATHNITAWRIRGEGTGHQQFNDDGETGAGSRLLQLMQSMDLWDSMVVVTRWYGGAHLGSKRFRLITSVASDAFARAGMSGDKKGDTPEGKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX30</accession>
    <name>S0DX30_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_13198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429101.1">
        <property type="nucleotide sequence ID" value="XM_023575854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX30"/>
    <dbReference type="STRING" id="1279085.S0DX30"/>
    <dbReference type="GeneID" id="35406652"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13198"/>
    <dbReference type="HOGENOM" id="CLU_139293_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="129" mass="15312" checksum="F88459270C0D3C50" modified="2013-09-18" version="1">MATPTEIRYAYRHLYRNILKAVQYTIPARFVARDQLRRAFREPGATYDGRGIKRTIWFLQAAAKEKGLEHKILKNLLRVRQMRYRKRDYSAYDPLKHVAQEMKDANVTAYNHYDMTVAMLNKTMGLCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX40</accession>
    <name>S0DX40_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="21">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">FFUJ_13258</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19 21">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 26">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="21"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429157.1">
        <property type="nucleotide sequence ID" value="XM_023575923.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DX40"/>
    <dbReference type="GeneID" id="35406712"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13258"/>
    <dbReference type="HOGENOM" id="CLU_000556_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000015">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 21" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 21" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 21" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13 21" id="KW-0408">Iron</keyword>
    <keyword evidence="14 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="23">
        <location>
            <begin position="1521"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1234"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CCT67076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2211" mass="253004" checksum="897C3B3FA23667A6" modified="2013-09-18" version="1">MPNTSLRRPQKGFRRGGKVAYHGNRTRTFAASSRNEATSADEKWERTRLAHSIDENMGFARYESGKKREGWLVNIQPTSIEDERIPGGRAAVDCYFIEEDGSTFKATVEFDPYFLIAVKKGRESEVEEWVKRVAGDGVVKSIRRVEKDDLNMPNHLLGYRRTFLELRFANVNDLMAARKDIMPIAEKNKKNMNAMDAYAEVATSNGDFDLFDDSRDDDRNMNTALSDASDFIVDIREYDVPYHVRVMIDLDIRAGKWYFVEAKHGVTKVYPNEERSLPAEPVVMAYDIETSKLPLKFPDAATDQIIMISYMIDGQGFLITNRQILSEDIGDFDYTPKPEYPGPFMIFNEPDEKAVIERFFLHIKEARPTVIATYNGDFFDWPFVEARASINGIDMYQEIGWKKDNEDQYKCNYSVHMDCFHWVNRDSYLPQGSRGLKAVTVAKLGYDPDELDPELMTPYATERPQTLAEYSVSDAVATYYLYMKYVHPFIFSLCTILPLSGDEVLRKGTGTLCEMLLMVQAFQREIVLPNKYITPKEAFWDGHLLDSETYVGGHVESIEAGVFRADIPVDFAVDPGAIDELLGDLDAALKFVITVEEKKNFDDVENYEEVKAQIVERLNKLKEAPNRNEKPLIYHLDVASMYPNIMTTNRLQPDSMIQESDCAACDFNRPGKTCDRRLPWAWRGEYLPPKRDEYNMIKNALQNEKFPGKYPSSPMRTFQELSADEQANLVRKRLQLYSQKVYHKIHDSTTIVREAIICQRENPFYINTVRDFRDRRYDYKGKAKVWKGKTSSLQSAGAAQSEVDAAKKMIILYDSLQLAHKVILNSFYGYVMRKGSRWYSLEMAGVTCLTGAHIIQMARQLVERLGRPLELDTDGIWCMLPATFPENFSFKLKGGKKLNISYPCVMLNHHVHAKFTNHQYQTLVDKKTLKYETHSDNSIFFEVDGPYKAMVLPTSKEEDKNLKKRYAVFNDDGSLAELKGFEVKRRGELKLIKIFQQQIFKFFLEGETLAECYGAVAKVANRWLDVLHSKGTTLADEELMELISENRSMSKTLEEYGNQKSTSITTAKRLADFLGEQMVKDKGLNCKFIICARPKNAPVTERAVPVAIFSAEESVKRTYLRKWLKEEPSDTDPRALLDWDYYLERLGSVIQKLITIPAALQKVRNPVPRVPHPDWLQRRINIKDDKLKQKKLTDLFKKSPLEDITNISGSRLDDVEDFGSKLLKPKQVNAVIASSQAATTVQKRKSPEPAENPDPMSALPEVMPSASENYEAFLMYQKKKWKLQKQARIRRRQLFGDRRGGAVNNLQQTFMKQAHTTYMSNWQVLHLKATETPGIVMAYVLIDAKIHTLKVNVPRQVFLNLKSKDLPDVEVEGCEVEQVNYTLPNGHPSSHLFKLTVSEDIYFNESEKFSLLFNHPSVEGVYEKQVPLNIRAVLRLGNQCTIDATQHAVLGKGLEQGFDLAGLKRPAKTRTYLETSPLAYIYVSHITTGERQIFGIFSTTNDQAHVVILQKNKDSGQDLPNISKMYSEMLARRHAEAAGTNWQDCFTYQEKLHIKITQVTTRRKAHLEIGDVVKKMRKDEPRPQMMVIQSSQRKLLIHDVPILGEFPVLPLKYDVGDSSLPPLGWQSVIAKRLVGHYLGLGSWILHLTALARYGDVPLCNLERDDPRFLIDVAYARRLQANGVVLWWSPDARPDHAGYEKDDLLGPLDTVKMPNVNNPGTFSSVCIDIDVRNLAINTILTSSLINELEGADSVSFNPAADDSETLASENAFANAGVQVLREMVKAWWTEACRGSTMADVLVQHLVRWVENPDSFMYDRALHYYVQMMSRKAFQQLMADFRRVGSQVIFANANRLILQTTKAEVGNAYAYSKYIIKSIKSKPLFHFIDLEIKEYWDYLVWYDEFNYGGKACQEVIEAEEQNLETVMHWQMATFLPVRLQSTFQDWVIEFIQLMHQLKRPHNGDPDGTPRLTQLPSNGLEDHEGQILLGKAFEKPLKKDIIGLLNKQKRELLHPELAQDYTFPVLPGSHLKPRNPILELVKSLMQVLSLDKNITLEARLLRKELLALFEVREFSKDGSFTNPSESLRLPQISCDSCTMMRDLDLCRDEDLFGEGAAWCCGFCGTEFDRVAIEERLLGIVESWIVEWTTQDLKCARCGALRLNDFMEHCTCSGEWKEIVSRQDVSKKLGVMRRVAKFYGLRMLSDVVEELHKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX87</accession>
    <name>S0DX87_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to large neutral amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_13323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429217.1">
        <property type="nucleotide sequence ID" value="XM_023575996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX87"/>
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        <property type="component" value="Chromosome IV"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
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        <property type="entry name" value="AA/rel_permease1"/>
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    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
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    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
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    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="195"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="270"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT67136.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
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    <sequence length="610" mass="66078" checksum="B43353FA2C6C49EA" modified="2013-09-18" version="1">MAPPYGLPSNTRDSLELASLASSSQPNEEGATEISSRPSISSSRRLSLEQDDPLDSANPANRMNRSYSVSSAFDFSANMFPLSSTTGAEGYAPIGAPTSRSRPSGGLGGGSLEKNKTLTYLNGLSLIVGLIIGSGIFSSPGSVSTRVGSPGAAILVWIIAGILAWTGAASYAELGGAIPLNGGAQVYLAKTFGEVIGFLFTWVAMLVLKPGSAAIIAIIMGEYFVRAFIGPDAEHVSPWINKAVALVGLFIVTFLNCVSTKLGTRVNDTLMFMKFIALLGVTVIGIVVAITGKTLKGKSEVEWKPHQLFENTSTDMSAWALALYAGLWAYDGWDNTNYVVGEFKNPTKDLPRVIHTAMPLVILCYVLANIAYFLVLPLESMDGSNTVAVMFGNRVFGSVGSLILALIVSASCFGALNSSTFTSSRLAYVAGKEGYIPSIFGTIGIGGSPHEHELSTQRTRSWFTRKMRRMFGDEDAGLFYTPVYALLLNAVLTVGYVVVGEFSTLVTFYGVAGYTFYFLTVLGLIILRVREPGLVRPYKTWITTPIIFCCVSLFLLSRAVFAQPFQTIAVVFFVVAGVPVYFWRIRGRDEQVLRRRGQPSEEKKWWQFWK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-10-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXJ2</accession>
    <name>FUB8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Adenylate-forming reductase FUB8</fullName>
            <ecNumber evidence="12">1.2.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Fusaric acid biosynthesis protein 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Non-canonical non-ribosomal peptide synthetase FUB8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FUB8</name>
        <name evidence="11" type="synonym">NRPS34</name>
        <name type="ORF">FFUJ_02115</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Planta" volume="225" first="223" last="234">
            <title>Fusaric acid induces apoptosis in saffron root-tip cells: roles of caspase-like activity, cytochrome c, and H2O2.</title>
            <authorList>
                <person name="Samadi L."/>
                <person name="Shahsavan Behboodi B."/>
            </authorList>
            <dbReference type="PubMed" id="16868776"/>
            <dbReference type="DOI" id="10.1007/s00425-006-0345-6"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="J. Appl. Microbiol." volume="104" first="692" last="698">
            <title>Bikaverin and fusaric acid from Fusarium oxysporum show antioomycete activity against Phytophthora infestans.</title>
            <authorList>
                <person name="Son S.W."/>
                <person name="Kim H.Y."/>
                <person name="Choi G.J."/>
                <person name="Lim H.K."/>
                <person name="Jang K.S."/>
                <person name="Lee S.O."/>
                <person name="Lee S."/>
                <person name="Sung N.D."/>
                <person name="Kim J.C."/>
            </authorList>
            <dbReference type="PubMed" id="17927749"/>
            <dbReference type="DOI" id="10.1111/j.1365-2672.2007.03581.x"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Arch. Pharm. Res." volume="34" first="1177" last="1181">
            <title>Antimycobacterial activity of fusaric acid from a mangrove endophyte and its metal complexes.</title>
            <authorList>
                <person name="Pan J.H."/>
                <person name="Chen Y."/>
                <person name="Huang Y.H."/>
                <person name="Tao Y.W."/>
                <person name="Wang J."/>
                <person name="Li Y."/>
                <person name="Peng Y."/>
                <person name="Dong T."/>
                <person name="Lai X.M."/>
                <person name="Lin Y.C."/>
            </authorList>
            <dbReference type="PubMed" id="21811925"/>
            <dbReference type="DOI" id="10.1007/s12272-011-0716-9"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Toxicon" volume="57" first="176" last="178">
            <title>Phytotoxicity of fusaric acid and analogs to cotton.</title>
            <authorList>
                <person name="Stipanovic R.D."/>
                <person name="Puckhaber L.S."/>
                <person name="Liu J."/>
                <person name="Bell A.A."/>
            </authorList>
            <dbReference type="PubMed" id="20955724"/>
            <dbReference type="DOI" id="10.1016/j.toxicon.2010.10.006"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="Planta Med." volume="78" first="1562" last="1567">
            <title>In vitro acanthamoebicidal activity of fusaric acid and dehydrofusaric acid from an endophytic fungus Fusarium sp. Tlau3.</title>
            <authorList>
                <person name="Boonman N."/>
                <person name="Prachya S."/>
                <person name="Boonmee A."/>
                <person name="Kittakoop P."/>
                <person name="Wiyakrutta S."/>
                <person name="Sriubolmas N."/>
                <person name="Warit S."/>
                <person name="Dharmkrong-At Chusattayanond A."/>
            </authorList>
            <dbReference type="PubMed" id="22864988"/>
            <dbReference type="DOI" id="10.1055/s-0032-1315146"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2013" name="Planta" volume="238" first="727" last="737">
            <title>Fusaric acid induction of programmed cell death modulated through nitric oxide signalling in tobacco suspension cells.</title>
            <authorList>
                <person name="Jiao J."/>
                <person name="Zhou B."/>
                <person name="Zhu X."/>
                <person name="Gao Z."/>
                <person name="Liang Y."/>
            </authorList>
            <dbReference type="PubMed" id="23838885"/>
            <dbReference type="DOI" id="10.1007/s00425-013-1928-7"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E70226" last="E70226">
            <title>Contamination of bananas with beauvericin and fusaric acid produced by Fusarium oxysporum f. sp. cubense.</title>
            <authorList>
                <person name="Li C."/>
                <person name="Zuo C."/>
                <person name="Deng G."/>
                <person name="Kuang R."/>
                <person name="Yang Q."/>
                <person name="Hu C."/>
                <person name="Sheng O."/>
                <person name="Zhang S."/>
                <person name="Ma L."/>
                <person name="Wei Y."/>
                <person name="Yang J."/>
                <person name="Liu S."/>
                <person name="Biswas M.K."/>
                <person name="Viljoen A."/>
                <person name="Yi G."/>
            </authorList>
            <dbReference type="PubMed" id="23922960"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0070226"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2016" name="Environ. Microbiol." volume="18" first="936" last="956">
            <title>Two separate key enzymes and two pathway-specific transcription factors are involved in fusaric acid biosynthesis in Fusarium fujikuroi.</title>
            <authorList>
                <person name="Studt L."/>
                <person name="Janevska S."/>
                <person name="Niehaus E.M."/>
                <person name="Burkhardt I."/>
                <person name="Arndt B."/>
                <person name="Sieber C.M."/>
                <person name="Humpf H.U."/>
                <person name="Dickschat J.S."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="26662839"/>
            <dbReference type="DOI" id="10.1111/1462-2920.13150"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>DOMAIN</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Non-canonical non-ribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:26662839). L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism (PubMed:26662839). The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and linked to the NRPS-bound amino acid precursor by NAD(P)-dependent dehydrogenase FUB6 (PubMed:26662839). FUB1, FUB4, and the non-canonical NRPS Fub8 may form an enzyme complex (PubMed:26662839). Further processing of the NRPS-bound intermediate might be carried out by FUB6 and the sulfhydrylase FUB7, enabling a spontaneous electrocyclization to close the carbon backbone of fusaric acid (PubMed:26662839). Dihydrofusaric acid is likely to be released via reduction by the thioester reductase (TR) domain of FUB8 whereupon the final oxidation to fusaric acid may (also) be performed by the FMN-dependent dehydrogenase FUB9 (PubMed:26662839).</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">Contains three distinct domains: an adenylation (A) domain that activates the substrate amino acid which is subsequently covalently linked as a thioester (aminoacyl-S-PCP) to the 4'-phosphopantetheine prosthetic group of the second domain, the peptidyl carrier protein (PCP) domain, as well as a thioester reductase (TR) release domain.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="10">Impairs the production of fusaric acid (PubMed:26662839).</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="3 4 5 6 7 8 9">Fusaric acid is phytotoxic to plants such as cotton and banana (PubMed:20955724, PubMed:23922960). It has been shown to induce programmed cell death in plants (PubMed:16868776, PubMed:23838885). In addition to a mild toxicity to animals, fusaric acid exhibits acanthamoebicidal, antioomycete, and antimycobacterial activities (PubMed:17927749, PubMed:21811925, PubMed:22864988).</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the adenylate-forming reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="12"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="S0DXJ2"/>
    <dbReference type="SMR" id="S0DXJ2"/>
    <dbReference type="STRING" id="1279085.S0DXJ2"/>
    <dbReference type="EnsemblFungi" id="CCT65193">
        <property type="protein sequence ID" value="CCT65193"/>
        <property type="gene ID" value="FFUJ_02115"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02115"/>
    <dbReference type="HOGENOM" id="CLU_002220_0_0_1"/>
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        <property type="component" value="Chromosome III"/>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
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        <property type="entry name" value="FAR_NAD-bd"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
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    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
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    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
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    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
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    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000437339" description="Adenylate-forming reductase FUB8">
        <location>
            <begin position="1"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="544"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation (A) domain" evidence="1">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thioester reductase (TR) domain" evidence="1">
        <location>
            <begin position="658"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16868776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17927749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="20955724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="21811925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="22864988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="23838885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="23922960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="26662839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="26662839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12"/>
    <evidence type="ECO:0000305" key="13">
        <source>
            <dbReference type="PubMed" id="26662839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT65193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1036" mass="115068" checksum="31C7FFF763B4B490" modified="2013-09-18" version="1">MGSISHLPVYGHRLLPVVIDEIARDEPDRVLFYTPRNGQPSQGYDKVTTKIFANSINRLCGWLDSQLGSPTVSKTIAYIGQNDLRYFIMMIASTKLGHRLLLSSPRNSVEGHVSLIKQSGCEFWIASSGLDHHGFLQDLQIPSVEAPELSQLLDPTPLKPYVYQKSWNEGKSDILALLHTSGSTGLPKLVPVYLETAATVDGFHLMELTNGKRPTGVEWTGTRQLCAMPLFHVAGICLGLYSAVFFNWTVVLPSVGPIMQHVIEDALDHITLDSAFISPSVLQDISKSPRVLEKLSKLKFITSAGGPIPQSVGDLIHPRVPIMQTMGMTEGQWLASVVTHPDEWAYYYFHPRTGVEMRPYSEDLSELVFVQNPKLTATQPVFKTFPELDIWETKDLYSRHPKHPSLWKYEMRRDDLVILSNGEKFNPLAAEGKLISHPWIAAAYLTGRGRFQTAALLYPDETNLDKSDDTIIDNVWPTFEEVNRSLPAFAQIHRDFVKIVRTPFPRTPKGTLARNETEKAFTADINAIYDRSTHGKPSVHINGTTEVVVRSGIREAIEAVSGLVDLKDDDNIFTRGFDSLHVIRLAGLLSSAFDQPIEVEVGTIYTNPTVSQLARSVWSHLEHGPQDKIHHSEATREMLAKYAQAFEPPREAKEHIVITGTTGEIGSYLLDVLCNNDKVAKIWCLNRSADAFQRQVDSAKSKGLSSTWQSKAKFVRYDVAADNLGLSQDDLQEIKNQATAIIHNAWEVNFNLPLSSFEPQFVGLQSLVDICREARHKLRFFFISSISAAMNWPSDLLGPVPEASIPRFDAPINGYGSSKLVAEHLLSKAARSGVLSLSVLRVGQVAGPVKTLGEGSIWTRRDWVPAIIDASVHLRALPLDLGTASILDWIPIDLLTEVIGQLVVPVNAVVGQENYYNLLNPRTPSWIDALPGLKAHLEVSFSDKFEIIPLHEWIGRLRGAEKTIVKEVSEGSSETARRAQSGLKLLAFFEMLASGEEGSRGLEWSKGNTLAQSSILACMEPVSSAWFGTWLTQWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY52</accession>
    <name>S0DY52_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to Staphylococcus multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_02327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427469.1">
        <property type="nucleotide sequence ID" value="XM_023574044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY52"/>
    <dbReference type="STRING" id="1279085.S0DY52"/>
    <dbReference type="GeneID" id="35395809"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02327"/>
    <dbReference type="HOGENOM" id="CLU_025894_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT65388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="460" mass="50170" checksum="969E5702AD6C2777" modified="2013-09-18" version="1">MAVTGRFLSSIGADVLWRSSRDLKILILLRFIRLLGYGGTTLVLALYLNALGFHDTQIGLFMTLTLVGDLAISFILTWVGDRVGVRLTAVVGALLMSAGGVAFAYFENFWLLLLASIVAVINPSANEIDPFKAIEESAIARLSTAHTCNDMFAWWSMLGMFGTAASNLLTGWLINALEDNGMKKLDCHRMIFLGYAGIGLLKLMCSLLLSSEVEQMPLQKESCSTPQSGILTPEEELSDDETAPLLDDNSSGYGAVPQTQVQVLAAAQEKRLFTPASFDFMWKLSLALILDFVGSGLAQISWMTYFFKREYDMPEGALGSATFTAGIISSVLNLASSPLSRAIGQVQTMVLCHTVNSISLLMVSVPGNKYIALVIFIFRIVTREIDNAPRQAFISAGVLDHERTSAMGVVNITKTIGSCLGLYITGLFAGLDKFWLAFILAGALKLSYNVLILAFFWKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY54</accession>
    <name>S0DY54_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to mfs-multidrug-resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_13592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429466.1">
        <property type="nucleotide sequence ID" value="XM_023576294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY54"/>
    <dbReference type="STRING" id="1279085.S0DY54"/>
    <dbReference type="GeneID" id="35407046"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13592"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF12">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="594" mass="65093" checksum="CF85E286AA4499B3" modified="2013-09-18" version="1">MKEDLEEASPANGAESSSSASSTGSSPILEPIRTIETRRSRTHDLDVFEALEHALTPDVETEAEREAREPITYTRTGTSVTSAASRPPDFEVFFEDGDPDNPRNWSKGYRAWIIVCVSYSTWVVVLYSTCYTASISGLAEEFGASTTVTTLGLTTYLLGLAAGSLIVAPLSELYGRQKVYIVCLTVWALLILPCALATSLTEIIVVRFFGAVFGAAMISNSPGTIVDISDPDYLAAAMSMWSIAPLNGPSTGPIIGGFVYQYLGWRWDNWIPLILGGVGILMMITVQETYHPAILKQKAARLRKENDDPRYWCQYDQRVSTRHLIKINMSRPFTLLASEPILWFMDIWISLIYAILYLCFVAYPIVFSQHRGWDAGMSGLAFVGIGVGTMLAIFAEPLFRRLINSQPRDPVTGRPQPEATALVMAIGAILTPIGQLVFSWTCLPATIHWAIPIAFGIPFGAGNTISFIYGSNYLAGAYSIYAASALAGNAVIRSIAGGVLPLAGPKIYAAMTPQWAGTLLGLLEVAMIPIPFVFWRYGAKIRAKSPTIRALREEQDRLDAKRAKYQKKLEKKQQREAENPKTEGEGVLEKTAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0T5</accession>
    <name>S0E0T5_GIBF5</name>
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        <recommendedName>
            <fullName evidence="3">DUF952 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_07260</name>
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    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
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        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
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    </reference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="CCT68474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13294" checksum="39DC4A1CC981A0F2" modified="2013-09-18" version="1">MSVESPPRFIYKIVPSPPGEPFPKEHPLSELDQNDGFVHLSTSTQVPKTAGLFFARSSSLWVIKLEFKQFADSIRWEGGFPHLYGNFGADNVDSTMKFVRQESQTWGEVMAKSEWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0X9</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
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            <dbReference type="PubMed" id="23825955"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1434"/>
            <end position="1459"/>
        </location>
    </feature>
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            <end position="1255"/>
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            <end position="21"/>
        </location>
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            <end position="82"/>
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        <location>
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            <end position="105"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="187"/>
        </location>
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            <end position="215"/>
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            <end position="237"/>
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            <end position="301"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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    </feature>
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        <location>
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            <end position="816"/>
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    </feature>
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        <location>
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            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="912"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="948"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1373"/>
            <end position="1416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT68325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1459" mass="161741" checksum="4C3EA272604C4C93" modified="2013-09-18" version="1">MQSWSNNGQNGADETQHQWHNNYAFAGQNGQFDPHQPWSQPVSEQAAYSQLNPQDASPSNFFDSDQSHPFLSSTLHGSQQDQAGYHPSHDSLSMNQQFPQQSQDVMDTDFSGIHPDIYGQHGKMNLDNAMAGIGQLSSHPHSTNFPYSMAPQNESSFEPSIQQFSQQHVMPQTSRQQSHTPVQQFDSIPSAYTPGHNFSRPPQPSPVQNQQQYNQAAFSPPVNGQTPQPRPNDQLNFQQGHPQARQQPQPQQQPPKPQQQMQQNQPQKPSPQPQFAPKQPVAYPQTSQPLPGQNFQQSIHHQQPPHFINNATSPPTANTQYILSQPGTNQDTGALQPATNEPPPKKRKRVVKTEVNTPTPTPEPTAAYVDSPVGSPAVKKIDDLDGLSAPTPTPEEAQLINQFNMRTKAAQAKFPVIKGLPHLVHDGTIKLPAPKSYDKLAPLVALPARSGRQMVPELGYSLPCEVQGRFTSQYRPSPDKGGLDERRMEAKVLLDDFDRSMKSLGKRRPKYTEYPHAFKEQLKSDEASKNKAEKKAKKELEEERGKPIRAATRPADPAEAAAWDAIGMVHIEQSVARTNALIASRVQQAGEYFIKLRSEMNRAKQELDQAIKDKKPDGVVARDRQDFEQKKEILYRALDATIEHADDAVLDNLGGHQKLVLSLVNALIMCIKASDFSGKLPKIVLEMFTHFPMTKKIAETTNFETVRKRFADKGDSEVKELVSEITVKVKKLKASESESTGYQGTSASSRAKAKPGLEPSAKRGRDEEAETRTVKKIAVESSGNALSRKLAQPKIQLQSASKTSAAKAAAASILPGKPRPVAKPAPKPETKADVKVISDDKIKAEAKPSRTETKPPAPRNGTTTALSSSSASALSGIASLLDSINAPKVEAPVAPKETNGSETSESPEEKAKRLRKEARRKLRVSWKPETELVQIRIFQKEEAEDEGRESNMTRDAADDRSEGMVLKQRANVEEEEDDEDVPYQPWMGPVAIDFSRLPTDVRNKNFVTRGGNVTFTTDEQQRIADREQRELMAIYTDPDDIPPSPKSPIPEVAGPDQQKTQYLPDDSKFQEIQVRWRDEQQMGSDGALYTALQRIEAKNNPGTRLDSILGNLRGVSSAARTSPQHATESQHHPALANDTLPLIAGRAVLEQVIAMLKSDKVKSWRDSNPITTDAWRTFHYSDTPTRLCGGAIEGVAKSLAGMPFPSNSPPEWILHDQEKVREWQMGHNKELVSRQKRADEERARAEAEANALQAAAVGASSGQAPANPQDWAAYYAQQQQAYAPYMALLQQIQPQPQTTTAPVQQQPQIPDTQLQSILAAINQPSQALGQASTAAPNVASYLNPNDPSYQQYMMLTQMAQGQQVPPPPPPPAAEREWDRDRAYSRDRDQDRGWDRERTYDRDRDDHGGRGDRDGKDGRKKKPTLPPHKPANKALIGTKPCTFWQQGKCARGDKCTFRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2K4</accession>
    <name>S0E2K4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431129.1">
        <property type="nucleotide sequence ID" value="XM_023578299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2K4"/>
    <dbReference type="GeneID" id="35401462"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07985"/>
    <dbReference type="HOGENOM" id="CLU_032674_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="416" mass="47323" checksum="B39389767D8B1332" modified="2013-09-18" version="1">MDLNRSDMERLRADLIQRSRMERGGSPNGGDVNLDVNVDVEAQHNIQEPRSSPPPLSRLLSRREPASMTGQAHLAEIESVKSQDSNTNRPGGSRRFAVPGFLRIWGRNNTTPQSDDIRIATASPAPLLPIAESQSPTRPEPVAAPSESHRSRRQRRQRNPPQDPLEAHLSEILGGSTIRRHRRRREYHERERDRHRSRRSHQRHPKFFLGCIPWVRSRRMRAQILRCLTSGLFLIILVTVYLALSMTHKVNTREMNIMLILVVLFAAAFFFHGLIRLCLLIIKSNREAAERANRPPRYRAPRYAVPPVPIPVVLAQDEEAVGMESEATKTLPPAYGRWRETVRVDPDRLFWQRNEAVDLSQIRPNTRAGPRPPSYVSEDGISYVVEAQPRSTAPTTEVPLPTHPSELGRVARVPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2X4</accession>
    <name>S0E2X4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431241.1">
        <property type="nucleotide sequence ID" value="XM_023578430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2X4"/>
    <dbReference type="STRING" id="1279085.S0E2X4"/>
    <dbReference type="GeneID" id="35407800"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14348"/>
    <dbReference type="HOGENOM" id="CLU_275710_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="2">
        <location>
            <begin position="882"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1157" mass="128414" checksum="CBD3AC4C14703F16" modified="2013-09-18" version="1">MTVNETTVFRDSDRLLHVPRKFKTVASTVTASIFRNVLPVPPAPSRDRRVSCDAKTPPHNSTAQTILAETADDVVLPDDAQHQEPIPIPDEPEHQQETGPFRDAVELPHVSPKIYVYPHSGGEVNDAFRSRFHEVVNLFRLNTEQHSPLKAHLEHIDYELRMCGTSILEAHPSIIVFCRPSEFSYLRSLLNSKHLKMQYCLRKSSPRYSWKTWGKSAVTQPSDTFKPLFNLYFWRAQRPRILYSHRHSMESASVLVEPAEGPYSRLTMSGSVVAASLPGGGHLTSTIGCILQVDSRFYGLTAGHLLHRERLHGTKSPQCGDSTCTVRTKDALQGPDAASIITQARASLSDDGSSMISGVDMAESAYTAHTSLPDSGLNHQITNDLSTDDDDFVDDIDYDDLVENDRDAPRAVEACQFQPILSENGQARKTTILAPSSCPIIGACCKVPDNDWALIALDTTESRLPNAFFDANRTSDPAFFSSTPGSLPEEETPVFIVTSNQRVLRGLLQPVPSFLGGITRKVQAEYWTVVLSRGAALHAGDSGAIVIGAGSPILVFGHIVASNPLGEVYVSPLGATMSQIAGLLATTHVSLPEPLPLLTGLASYHLGKEDDYAFELLKYLDECIQATQQTSDWSSLESWALCYQRVELLGAVKDSLRVAKDPAKIRLLQKFSPDHSEKVLGFDLVMSFEAESTALSTAMKSRTSTIFTDSTDDSDYEFDTAQPAMITPKDPWGWPRNTLDADSSASDIVPGISEHDLDSEQTGRKSKADERFAKESQSPEGADQAGHLDENVDMAQDPSEPSQQSTEPGHARRLSIDDDMFHQHLLVSKARLPSASSVWTTRPSHSDIDGGLGGTRAQIREQEIPPFPHETLPEYYCEIDLEGVFMRKMEIKNTTKRAENRQWQMIYATLHGTALNIYNVKKSWQWRLDKDGPHHNPDNPAWIGQGDLIKSYSLQYADCGIAADYKKRRYVIRLRVETDQFLISSVELSTFLAWLDGLNAAISVAAPMEDWDIPRDMSIPRIIRMQWLQDQEPSPTPDLAQLSRINSPQLSTTAENDNVPESSETTATGFPNVVAGLPRRWDSTGSSPDNSIHPVTGKWEPEHQWSVAHDLLYAKLCYPNLLFRSPRKSNFIISNGKKWYVDWTTGRMVQTLPPAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2Z7</accession>
    <name>S0E2Z7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to tol protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431319.1">
        <property type="nucleotide sequence ID" value="XM_023576943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2Z7"/>
    <dbReference type="STRING" id="1279085.S0E2Z7"/>
    <dbReference type="GeneID" id="35400243"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06766"/>
    <dbReference type="HOGENOM" id="CLU_002639_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="150"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1093" mass="124032" checksum="5AE1EA01A8FEF81D" modified="2013-09-18" version="1">MLDIEYLRGRGQEIESHLEENFDSAEFLPCTKIDQFLGRNAVELALKASGLNDREDLVNFVLQPARAKRIFLILLYMSEEREKLSFLANFLKQKLTDASLPVKKSQLGSIFTSNNDRTLFCKYQHMVTSPEFGKDKFRSKLHTDTILPYLKSHNPSGRGFFGEVSRMDIHPSHIPEDVRLTLGGTASIAVKTANNHDQIAKFFEQEATALERLKNHNSPNLVQPIAAYEYKNQKCLVFPWAHGGDLYKFWEAYQEKTVDLEWIISQFTGLCSVLNDLHKINCRHGDLKPDNILWYRDKDGLGTLKIADLGLAAFHIKDTGNRRGIQTMTPTGTARYEPPETAENKTGERSRMYDIWSMGCIMLELLIWLTQGIYAVDKLGTVTDYFWKRDDKSHRYEIHPEVRKSIEELYKHEAVQGNQTYSDLLTLVTNGLLVVSLQSDANQGAHRYEASKLYEQMLVIDNNYQGNGSVQPSQARSMTGRHRQERHSQNQASQLYDVWQSTSHNQFAAQFLSLVGWDNVRPDSNLALNNLCARCSSIKTTPLFSSTLPVEIQANCDLCSMLSIALDKQGIAWLEGVRIQQKDGAIGVLDAPYLLSVYSEPGQSVPHGARLGLPQLPDQGGTGQFLLLKEWARVCSLEHEKCRSGKDQIVKAMPTRLISVQEPVHLLDSSSIDPTDYIALSHCWGKLTEDQKFCTYKRNITQLRTKIDTDRLPKTFRDAIVVTRGMGIQYLWIDSLCIIQDDDIDWEQEAGKMEQVFSGAYCTISATAAKSSLDGFLSDRSPRPYVHLDTKDGRLWICPAIDDFRQDVDAAEISTRGWVLQERLLSRRTIHFTSNQVYWECGEGVCCETLGHLENPRAALTSDANFPSSVLKLYRDGRQMLIQDLHERYTRLNLTVSTDRSVAILGLETRLARALETQTAYGLFDTYFARGLLWKRGQESSMPIIPYQEDKRVPSWSWFHRKGVIEYMDLKYDRVDWMSGNFNNPFTTQQHGGSRQQATSEAPKCSHVLKAKAKSIKTDGTSLSEHIVFDDEKFDLDKVKCVTIGSDKIGGGRIHVLLITVFGAPEENKYKRVGVMSLRPTSVDGEGLWVDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E388</accession>
    <name>S0E388_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431356.1">
        <property type="nucleotide sequence ID" value="XM_023578139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E388"/>
    <dbReference type="STRING" id="1279085.S0E388"/>
    <dbReference type="GeneID" id="35401318"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07841"/>
    <dbReference type="HOGENOM" id="CLU_029210_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="257"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="476" mass="55026" checksum="681FCE3CFA124028" modified="2013-09-18" version="1">MATYQNGVAPARAIDDDSDVEEEALVAEYKEHVQYEDGDDLSRTTSLNLTAQTDDIQARLVQAAQPLDFQAPLEAKFQSYDAYCSLFHFILNSEGPVDLEPPSYYWAWDVIDEFIYQFNSFSSYRMRIARQTTNEEERQALRENPNTWGCYSVLNVLYSLIQRSQITEQLAAMKRNEDPLAVAGEYGSKNLYKMLGYFSIIGLLRVHCLLGDFSLALKTLDDIELNKKAMFARVMAAHFTTYYYVGFSYMMQHRYADAIRMFSHILIYVSRTKNFQKSAQYDSITKKNEQMYALIAICVAFQPTRLDDTIHSALREKYGDQLLKLQRGGPESLPIFEELFRAACPKFISPVPPDFENPEANIDPVEHHLAVFMDEVKTNMWSPTIKSYLRLYTTMDLNKLAGFLEVKPEELRSWLLVTKQRTKQLRWQDQGLLEGELVNVSDLDYALQGDLIHISEAKVGRKLVDWYLRNLSRTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3C3</accession>
    <name>S0E3C3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable CAP20-virulence factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_13402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429289.1">
        <property type="nucleotide sequence ID" value="XM_023576083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3C3"/>
    <dbReference type="STRING" id="1279085.S0E3C3"/>
    <dbReference type="GeneID" id="35406856"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13402"/>
    <dbReference type="HOGENOM" id="CLU_082150_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="182" mass="20337" checksum="4B320BD15453EBCD" modified="2013-09-18" version="1">MSHQVNGDVSAAQYSAFVQHLLNYPVISDGVHTFKSNEFGQRSIKLTDAAYQTFAAPVVPYFAKPYQYVSPYVQKVDSLGDKTLDRIDEKFPVVKKPTDELYQDTRALILFPIQKGLEGKDHVFQVYNSEIKKVEQGGLVAHGKAAVTTVLVVSNETLSWLSSFLHQKKAETTTAVNEKINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3Z4</accession>
    <name>S0E3Z4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to aldehyde reductase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431619.1">
        <property type="nucleotide sequence ID" value="XM_023578642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3Z4"/>
    <dbReference type="STRING" id="1279085.S0E3Z4"/>
    <dbReference type="GeneID" id="35398911"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05432"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="352" mass="38583" checksum="3FB0EE44F7638208" modified="2013-09-18" version="1">MPREQHDMTGSNKIVLVTSANGFIATHVVKDILQKGYHVRGVVRSQASADAVLKTFRDSSEFLSVTVVPSMTVAGAFDQAVKVVDAVLHVASPFTLDVNDNETELLVPAIAMTKGLLESASMYGAEIKRIVITSSFAAMVDLKKGLWPGHTYNEADWNQVTYDYAKTADAGTAYVASKALAEKAAWSFVQDRKPHFDITVLCPPMVFGPPAHFLSFSALNIAAWDINRFISGELQDVPNTDFWGFVDVRDLATAHVRALEVPEAGNERFLIAGGRYSYQQTADVLRASSRIPDNEKAKIPRGRPGDNYPGPNVYELDNSKSIRILGVEYRSFEESIVDSAVKVVEARRKAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4F6</accession>
    <name>S0E4F6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable complex I intermediate-associated protein CIA30, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431854.1">
        <property type="nucleotide sequence ID" value="XM_023578929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4F6"/>
    <dbReference type="STRING" id="1279085.S0E4F6"/>
    <dbReference type="GeneID" id="35399168"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05689"/>
    <dbReference type="HOGENOM" id="CLU_059028_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="6">
        <location>
            <begin position="44"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="263" mass="30111" checksum="61B1696FCA42293C" modified="2013-09-18" version="1">MRATPTLLSRGFFGRSMDELRRRTQIAVSFEAIKGATQPKPLYEFNTPDSVRDCIVMTDKTIGGFSESNFDFHKSTDANNDPKIPSAYARFHGNISTRLPSDRPNIQRTGFAGFRSPDQRPTAFGRSMWDIDPYIYLALRVKSDGRSYFVNLQTESVEPSDLHQHRLFPKRPGQWETVLIKWNDFVRTNHGFVVEPQTEMLRQKVLTVGIGLTDRVDGPFELCIERAWATNDPSEVDVTEEPKAETVAERGQLRNKKGEKVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E556</accession>
    <name>S0E556_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431976.1">
        <property type="nucleotide sequence ID" value="XM_023579075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E556"/>
    <dbReference type="STRING" id="1279085.S0E556"/>
    <dbReference type="GeneID" id="35399298"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05819"/>
    <dbReference type="HOGENOM" id="CLU_026731_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="658" mass="71850" checksum="87BE7E847FADA526" modified="2013-09-18" version="1">MSMSPQDVAVLIQREGSGASPETYDAANESDDAVVKRTKLLSSVLETLKQQDPSSLEATAKALGDGSRDVAWRLPYGDSGILEFFLDILAADEEQPHGVKVQALRVTGNSCADTDQNRARVVEGKYIVSFIKHLQDMSLVPYLIPVLYNVLVDYEPAQRLASESRLSSHLITLLQSPNRAAFSPLVTYFCKILALLITQDGEVAVADSETASVLLKLAVSPDHSTDIEDFLALVSTAASYLANESFQERLLDSKEADVFVKAFYIAHTQFDSELDDEDTAKELGQLCTSLLTTLADLTGNDAFPACYSLESSVPQSLLRWLKEPHVILQSAACLALGNLSRSDQASTAFVQKYQAHLPLIAILSNPEIKDAQLLHSALSFLKNLAIPAQNKTLLGDLLEPVSVPRILTIDTLPQVQFSAVSLLRLLLVNCPDNVRRVVTPRTAEGEGSGKHTTVHDMISLFDRSDTEPTRLEAARSVATVCRVLHTAPTEGVLSGWSSEIEKTPSRDLFYAEHDLSQVLAFLITQEKWPILKSEAWFVFALMSRSKDGAQVVAKILAISGAMDALSYAVTGKTTNDETPQIEGGAPEIPPAIPEELALEPQQVDPKQKANMAKVDRENCLVLCTEVVKNGETQESKQVDRLRSLIRQGTELLGKKAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E584</accession>
    <name>S0E584_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_07695</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430952.1">
        <property type="nucleotide sequence ID" value="XM_023577976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E584"/>
    <dbReference type="STRING" id="1279085.S0E584"/>
    <dbReference type="GeneID" id="35401172"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07695"/>
    <dbReference type="HOGENOM" id="CLU_091071_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT68872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="244" mass="26995" checksum="6536054C68C8AA7A" modified="2013-09-18" version="1">MGPSSNFGPNQPIPHKSLDNTSLSPSRVILKARPHCPAQTINRMFLQRSALTAARRVAARPAVARTFTTSFVRRDAARPATPNEQAAALAGTAEKKVGSYKTLKEVRTEEDLFGPGAAPGTVPTDLEQATGIERLEILGKMEGVDIFDMRPLDASRLGTMKDPIMVRSAGEEQFAGCTGFPADSHSVHWLGITRERPIERCPECGSVYKMDYVGPEDDHHHHHPPEFEEPKTFADYIKPEYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5I2</accession>
    <name>S0E5I2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_05955</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432100.1">
        <property type="nucleotide sequence ID" value="XM_023579224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5I2"/>
    <dbReference type="STRING" id="1279085.S0E5I2"/>
    <dbReference type="GeneID" id="35399433"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05955"/>
    <dbReference type="HOGENOM" id="CLU_011862_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
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        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
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        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="16">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="451"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="573"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="627"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT70021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="731" mass="80612" checksum="3CF9EC3F9B769458" modified="2013-09-18" version="1">MMSWWSSSANTALDEQIEKATSSSLEDIALNLEISDVIRSKTVAPKEAMRSLKKRIGNKNPNTQLSALNLTDTCVKNGGSHFLAEVASREFMDNLVSLLQAVGGGAVNADVKSKILELIQSWAGATEGRYELSYIGEVYRTLQRDGYQFPPKISVASSMIDSSAPPEWTDSDVCMRCRTPFTFTNRKHHCRNCGNCFDQQCSAKVVALPHLGIMTPVRVDDGCYAKLTNKGHKIPNPSLDRSPTYPHKTRSTSAMQPRNARVDDGFDEDLKKALAMSLEEVKTHSHGYAGPAQTSYAANGDASSAKQAEEDDADLKAAIAASLADMEEQKKRHAAALKEQTSSSMDASATTNFVLPKNDYELTPVEAENINLFSTLVDRLQTQPPGTILREPQIQELYDSIGTLRPKLARTYGETMSKHDTLLDLHAKLSTVVRYYDRMLEDRLSKAYSQQNLGGYNLPPPRQAAGPYPSIPSQMPSNPTGAESFYTGQQRASYQAPQHQHYQQPPPHATPQPQYPSYGSAPEAQPSQYPHHHQVQRADSWQNRAPSAPQDPYQQQQQPPQQPNDPNLQTQNSQQPQVPTASDPNSSYYLTPHQPQQTPLGPSAPDANQSPYPNLQQPSQYPGGSVSTPSQPTPSQTPAQIAQPVQPVQSPHMQHAQPPQPSQPQPPQPTQQAPPPQQQAYWQPSMPQSHQQPPVAPQNWAYGGYTQDSFPSVPQQEPVKQPVKEEALIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6C6</accession>
    <name>S0E6C6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432523.1">
        <property type="nucleotide sequence ID" value="XM_023579742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6C6"/>
    <dbReference type="GeneID" id="35399896"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06419"/>
    <dbReference type="HOGENOM" id="CLU_117282_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484895" description="Small secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15273" checksum="FA2E216E2F83C598" modified="2013-09-18" version="1">MQFSLACLAAILATSVSAAPAPAVNMMAASPQWTIENMQRSCAKDDSSCTWNFKIDTHKGAATGCKYVVKGSKASQRNGGPVKCGDFTITSGWSGQFGPGNGFTTFSVVSSKRQIVWPAYTDKQVQSGKVVKPDQSYTPANLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6T2</accession>
    <name>S0E6T2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiaminase-2/PQQC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432663.1">
        <property type="nucleotide sequence ID" value="XM_023579909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6T2"/>
    <dbReference type="STRING" id="1279085.S0E6T2"/>
    <dbReference type="GeneID" id="35400046"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06569"/>
    <dbReference type="HOGENOM" id="CLU_1004874_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19359">
        <property type="entry name" value="TenA_C_Bt3146-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484920" description="Thiaminase-2/PQQC domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="2">
        <location>
            <begin position="79"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="277" mass="31218" checksum="2F79F0C104684669" modified="2013-09-18" version="1">MSFSWSRMLHLLPALAISAAALPHAPATTEPIVTPVECPRHNSQVQDGTLVDQLWTQNCDLVTKFLNNAFTAAQAAQTSQGTLESLQYYFVQDYYYLTLTVPHKAYLLKSLDQDESAADQTSAINETVLDMTGDLEYASSFREDLTSPDHLNVSSSVVKNAKLEPVLREYVDWLGDNTNLGWYLWSISRLPCIYGWAEIAYQLNQSSTTVRDTKFYDEWISPNLEWRYGAKLSVELQEVLIANNNTATFSIANGLFRKALEYETAFFESALGKVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6W4</accession>
    <name>S0E6W4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trihydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_06622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-ulmin hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432713.1">
        <property type="nucleotide sequence ID" value="XM_023579968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6W4"/>
    <dbReference type="STRING" id="1279085.S0E6W4"/>
    <dbReference type="GeneID" id="35400099"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06622"/>
    <dbReference type="HOGENOM" id="CLU_141181_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23508">
        <property type="entry name" value="hydrophobin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.120.10">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010636">
        <property type="entry name" value="Class_II_hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036686">
        <property type="entry name" value="Class_II_Hydrophobin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341:SF1">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06766">
        <property type="entry name" value="Hydrophobin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101751">
        <property type="entry name" value="Hydrophobin II, HfbII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485343" description="Trihydrophobin" evidence="4">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT70634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10273" checksum="9EB87F908D5EFCF0" modified="2013-09-18" version="1">MQFYTIVSLFLAGTAFAAPATSSNGYEACPSGGLFGNPQCCSLNLVGVLSGDCRAPTKTPNSAKEFQEICAESGQKARCCGLSEILELGAFCQKPVGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6Y1</accession>
    <name>S0E6Y1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432519.1">
        <property type="nucleotide sequence ID" value="XM_023579737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6Y1"/>
    <dbReference type="STRING" id="1279085.S0E6Y1"/>
    <dbReference type="GeneID" id="35399892"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06415"/>
    <dbReference type="HOGENOM" id="CLU_106365_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="227" mass="25611" checksum="A377884A68AF68C2" modified="2013-09-18" version="1">MGQEEVGLEVLPPPPGYSPSNQDVEFIMPTSFTIHKEGDSEVKFNIRGNSGSTPLSIACTYKSTEDDFEARVNLLPRKDENASPLATVKYSRHSAELEFTNTSSPSNITLYYRLLGDRNATHSFNVNTPERTSFEWRNLGDGEGWKLYMGSRPEVLAVGALNMGSDKPTRFEFTDLEMAKELDEHCKLVIVASWLRIWDKVRIQFRRSPDEGETEMILCSCGFCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7S2</accession>
    <name>S0E7S2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432784.1">
        <property type="nucleotide sequence ID" value="XM_023580053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7S2"/>
    <dbReference type="STRING" id="1279085.S0E7S2"/>
    <dbReference type="GeneID" id="35400175"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06698"/>
    <dbReference type="HOGENOM" id="CLU_032323_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="445" mass="49568" checksum="C0A1B327A0A8D12F" modified="2013-09-18" version="1">MPSRYLFPARANHDLTLEITIDGHYESKVYTFGSTVSGLVTITAHHQLPFQSLQIDLRGITSTCGHAFQYGTPFKTHVFMQLQMPIPTSALPVNQSFEQGQLYHVPFRFVIPQQLSSAACNHQNKAVRERHLRPPPSMGAWDRDDLAGGSANVDYMIRARLLLSKNKRGEEQYLDQSRSFKVIPALPKQPPLHVSPENPEYCLSKSKTIRKGVVGTKMGLVRVSATQPEPILLCLDGLNSPMSRIPIDLEYIPMSSSAPLPEIRVKSATIETFTNFWLGIDGYLPDHHQKPSNSVAPTAPWLTSHALVLTGKEMARWQKDSQHVSEKESEKRFSEPLDVIQDCAEPHFTARSPSCASHRDFGSSKSNSYRAFILQSFGLPTEKSLFLPTFYSCLISRTYRIRVSLAIGAYGNTISLMVPLQVAVNGLDDTQNHGHLSSVSVIISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7U6</accession>
    <name>S0E7U6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433020.1">
        <property type="nucleotide sequence ID" value="XM_023580201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7U6"/>
    <dbReference type="GeneID" id="35402506"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09032"/>
    <dbReference type="HOGENOM" id="CLU_014491_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="712" mass="79953" checksum="B529DD7A44E2A7F2" modified="2013-09-18" version="1">MSTNLLSELKQFLGAFLRPNDAAEGEPAARFAHIQMPPYRLGKEGLMNLINNEVIHSSFAEKAGMNLFVVPESEKSDQFGAEHDVVSSQTLTFSALLDALRITRQASGSDLGWGYNLMGDAEADFRVRNILPLSVVLVLQLDPEMSADCALSLIGIVQWALFVSTVVPFSNIRVLTVSVDEDANFLSKLVHFSAPDIEVASMNLAAHGEQNPDHGSVVFKSHSIELCVEKIRESLESNKDRRLLVLSFDADITKPLIQKLGSDDKARFKIITAGTAPPDVNAVPAEKSLILRFPKPVSFLPLEFQGFDELHVFLSSKTHMAQAWDNISCQVIEYSRPLSREDRRLQYWWARQPSMQHKYLYFNEPALSLFLEAGGSRARLVETSQLGGFIAAVMDIMSWGFHVDKVLNLFIRKPLEVQEMRTRLQVQGLINPTGLALIDSEASVFRRLLSTFRYDYRLSMFVALDSDAQVRRVKLELATMQNLWVANMISIKPGITTTNKLSAELFEGCLGLSSSLARRGVLWLNLGLLKQHLSNPDKFKDYLVFNPRAKVVDRQVAQMLKLLPGQSESNDQRSMSEEVAVLSAEQERVLQKHLLRAFLYQLTLTYYPKVNGTRNGSNGFCHNLVSSMAKCDIEMLNTLTLINFKALYKKEGSEVAFGICHGLFRPDESRRVSCKDWTLIPAETVHEWLSEVAPEGNIFEVLHTGIQHFKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E804</accession>
    <name>S0E804_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433080.1">
        <property type="nucleotide sequence ID" value="XM_023580275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E804"/>
    <dbReference type="STRING" id="1279085.S0E804"/>
    <dbReference type="GeneID" id="35402440"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08966"/>
    <dbReference type="HOGENOM" id="CLU_002748_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="153"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="909"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="970"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1205"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1261" mass="139329" checksum="9C258B0DF061C94C" modified="2013-09-18" version="1">MDQHYHPPLGHYSAPEAGPHRLLPSRSSLSLQATIRHITDQGPVHTSRTWTSSGDHNILSDIDELGDRATFVQEYNRLAKKNGVRILVIDDFDSRHTGNGLGSPRKQGWLYRILRSSSNHPTADTQPRQGSRHKRSVSDLAHNLIHRRDPKILDLQSMVRICGKSMLYLPPEHTPSALILPTCIRATAHHIAQHVTTRGIFRIPGSIRVVNTLFDYYCCTDNIDITNTVRCANLPMHVQASVHDVASTFKRLLSVIPGGILGSLALFDAMVAIHSQLQGDPEFPRTKQTKVRARLIALAIATVQSQFRRELICAVFGLLSLIGRVAEITPREDEEGRSLPTGDLMGYNALGIVFGPLLIGDLLGLYSMKLAAPKAGMLVLPLRSPRSRQDRNGRKTFGNELGASPTMDKIIIANTIAEMLIVNWRDVVRQMKSLGMNRPHPRSTSQDDPNENGFVIRKPQGWDREWRGSDGDQIPREDSPEPPTPTLGISKQRSRSRGSSASKRLAARPNIGCLSPTVEESAHDEDKSQIPAQLGEGSSYVQTPQNFQMPTGAAHLKDSKDVAAKDTPGESAHIAPTPTPATRTRGLINRDGSHLSQEDVPPRTSSKRGTKTTPIQQTSPEEPTSQDTSRVSATETPSIERKGAIRKKYPAKAKALKPRRQSLAVEWTKPARSSDTSMDRPDSTSLEFSSEKGALEAALKAHFEELRELDSMDQRKSSASTNVDQNSEMSTFANTPNVLHFPIDRLEEERDYTICGDKTRTQTLQVANSASTTPRQFYSPMQVPASIAGGSSSMGLASPKSQSLEYDETKKQAKGIGTETPERRYSRVMSLPAETPKTEKQRTASSPWFSVPKRKSTALTRPNLTPTDNPGGVRAMAAKFETDHSTETSPTKPRSASKTQDLILQFSQESPTKSIRSTRSVSTLGHKRNISISSQDRRSRPSAINTVRDEALDQNLRVSIREEAAMRAVELQQADKGQKSSSQEQPEMLAQRQTVPRRKPVPGSRGKEASLENPRSLGTMMPYPEQPPIAQHLNLIRPASSASNTQYGADPSVPQNISTPFQRPGSTTTLHAQIRSLQRQLDLKTEEAIHLRRQLEVQGDADVGTLSQQLREAKREAQTWRERAESAERRIKVFERFTARLKGIREAVGVDTRNADTDTAKYLDGGANGQTENTLENTMGYESDSSGRTEDAGVVKARIRRCLHGLTDGPPDKPSFGLDEIQNPGPERPKRDISPSTLEVWMAAQELLQLDEVQGQRETNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8I3</accession>
    <name>S0E8I3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_08745</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433283.1">
        <property type="nucleotide sequence ID" value="XM_023580519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8I3"/>
    <dbReference type="SMR" id="S0E8I3"/>
    <dbReference type="STRING" id="1279085.S0E8I3"/>
    <dbReference type="GeneID" id="35402221"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08745"/>
    <dbReference type="HOGENOM" id="CLU_044838_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <keyword evidence="21" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="59"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT71204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="278" mass="31534" checksum="D0741BD5F06CA728" modified="2013-09-18" version="1">MAALRSSSRLVGAFSRTAAFRPGAVFTRSMASVSEPPKDSNANLKSFQIYRWNPDTPSEKPRLQTYTLDLNKTGPMILDALIRIKNELDPTLTFRRSCREGICGSCAMNINGQNTLACLCRIPTEAASDVKIYPLPHTYVVKDLVPDLTHFYKQYKSIKPYLQRDTPAEDGKEYRQTKEDRRKLDGLYECILCACCSTSCPSYWWNSEEYLGPAILLQSYRWLADSRDERTAERKTNLENSMSLYRCHTILNCTRACPKGLNPGKAIAEIKKQMAFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8K9</accession>
    <name>S0E8K9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_06053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432191.1">
        <property type="nucleotide sequence ID" value="XM_023579334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8K9"/>
    <dbReference type="STRING" id="1279085.S0E8K9"/>
    <dbReference type="GeneID" id="35399531"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06053"/>
    <dbReference type="HOGENOM" id="CLU_054456_0_1_1"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="62"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT70112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="307" mass="33356" checksum="FD3FD058F8E8442E" modified="2013-09-18" version="1">MGDLPTTFDKPVHIAVIGGTGLGQLEGFEPVAALTPITPWGPPASPIQILSHKGGYVAFLARHGVHHQFAPHEVPNRANIAALRHIGVRSVVAFSAVGSLQEEIKPMDFVVPDQVIDRTKGIRPFTFFEGGVVGHVGFADPFDAGLAKVVKACAAHMEGDGVVLHEKGTVIVMEGPQFSTRAESNMYRSWGGSVINMSTLPEAKLAREAELAYQVIAMATDYDCWHSFEDVNVELVIKYMKANNENAKRLVAGVLDRLAELENSDLVQAKHWAGASQGAVKFMTKPAGRDPEAMKKVEYLFPGFWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E951</accession>
    <name>S0E951_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to nucleotide-sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433500.1">
        <property type="nucleotide sequence ID" value="XM_023580782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E951"/>
    <dbReference type="STRING" id="1279085.S0E951"/>
    <dbReference type="GeneID" id="35401984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08508"/>
    <dbReference type="HOGENOM" id="CLU_025028_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495719" evidence="6">
        <location>
            <begin position="23"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="414" mass="45623" checksum="D8FD84560A39FC67" modified="2013-09-18" version="1">MASRSLIPFLVAMMLLTGVCNTLLTKYQDNQCVRNCGPDDNPRKRAFFNQPVLQTAQMFIGEMGCWLVVGLMALWRRFKGSAPEDRGYQAVHTEENGDAEAAPQADDRTKLLHTGPSILRGYRVTLLALPAICDICGTTLMNAGLLMVAASIYQMTRGALVLFVGLFSVVFLKRHLHLFQWLSLVGVVLGVAVVGLAGAIWPDEKPENSIGQPEEDSATDGGLSDAARAIVGVLLIAGAQIFTATQFVLEEYLLERSTIDPIRVVGWEGIFGFSVTLLAMLVLHATIGSTEAGKYGYFDIVEGWRQMTENKQVLISSFLIMISIGGFNFFGLSVTRSVSATSRSTIDTCRTLFIWIVSLGLGWETFKWLQIVGFALLVYFTFLFNGIVQPPLEFLRVPDGEVEELLPEEPIEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E958</accession>
    <name>S0E958_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433264.1">
        <property type="nucleotide sequence ID" value="XM_023580497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E958"/>
    <dbReference type="STRING" id="1279085.S0E958"/>
    <dbReference type="GeneID" id="35402241"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08765"/>
    <dbReference type="HOGENOM" id="CLU_050866_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518:SF1">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="288" mass="32436" checksum="BEF9AFEBF5C6E41E" modified="2013-09-18" version="1">MADSHIPSVPPPWTLKGEIYAFLFWTSPSQAKEGLPSIAYSPLEGQSSFAKDQKALGGLSMLQLIRYTDSPVGPYDELILAPGTFGYEKEDENGRKVKGKGVKITRIYVSHKHTCYNGRKNWNVPKHLAKFDWINNSNGSTTVKVYPHDTLPTDSASPESASPDPTPFFQATFKPIRYAPSFPFRTSWINFLGFDTTLVFPPLPEGFGSQGELPGTDQWCSVVPQQSTSKCMLGWFDVEQHRGEQGKLTGEFENFWPGWSKWQIGIKMENSVIEFDHPEAWEPPRTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E989</accession>
    <name>S0E989_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable RIB2-DRAP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431103.1">
        <property type="nucleotide sequence ID" value="XM_023578268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E989"/>
    <dbReference type="SMR" id="S0E989"/>
    <dbReference type="STRING" id="1279085.S0E989"/>
    <dbReference type="GeneID" id="35401434"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07957"/>
    <dbReference type="HOGENOM" id="CLU_016902_12_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="190"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="514" mass="58416" checksum="B4D83F33D2BDC519" modified="2013-09-18" version="1">MATSSPKLEASSSEDNIFANSFQDLDIQSDKGLTPSPVPNQPSSDPPQTATNNKKQQNQRRPKQKKKQDPPKVSESDEPLITPVGDPWPRPYHFEGDGLRRVVPYHYTYNTHCKERWRNRPLLEIYESEFRDRPLEYYRQSMIRGTIFVNGRRVGPDYILRNGDLISHTLHRHEPPVTEDPVQIIHEDEDMIVINKPAGVPVHPAGRYNFNSVVEIMKSDRGPAFLPYLCNRLDRLTSGIMFIAKNPPAAEALGIKIKDRTVRKEYIARVMGEFPDGEVVCDQPILQISPKLGLNRVRANGKTARTVFKKLAYYPAEGENDVNERPKTPEQVQEEKLRPWVNKKGYSIVRCLPVTGRTHQLRVHLQHLGHPIQNDPIYANRRVWGVDLGQNDADATQNTDEDIVSRLSRMGKDEVAEAVAYYDAMVDRYEEKRAEKLTGELCDICETPLYSDPGEHELSLWLHSLRYEDAGGAWSYVSPLPRWALPPKGMSGPTSVGGMEELVEAVKDENPEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9U7</accession>
    <name>S0E9U7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433760.1">
        <property type="nucleotide sequence ID" value="XM_023581101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9U7"/>
    <dbReference type="STRING" id="1279085.S0E9U7"/>
    <dbReference type="GeneID" id="35401698"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08222"/>
    <dbReference type="HOGENOM" id="CLU_071125_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485416" evidence="1">
        <location>
            <begin position="23"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="203" mass="22231" checksum="1EEC1FB64FFBC83E" modified="2013-09-18" version="1">MKFTTLSLIASLASLSAASLSAVPIIEAIAPKSKSCPTGNKECRTATQAAPYIISSFQTQGIYSPAEIAAVLALMAFESGDFEYKRNHYPGRPGQGTANMQMPNYNLLYAKSIPELAKGWQGIDSVEGLSDQELGDLLDDVTVDKYNFGSGPWFLKTQCKDDVRQAFKTDVDTGFQKYIEECVGTDLQPRLEYFQRAKTAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAZ6</accession>
    <name>S0EAZ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434117.1">
        <property type="nucleotide sequence ID" value="XM_023581414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAZ6"/>
    <dbReference type="STRING" id="1279085.S0EAZ6"/>
    <dbReference type="GeneID" id="35407419"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13965"/>
    <dbReference type="HOGENOM" id="CLU_062263_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF6">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485447" description="Secreted protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="32551" checksum="E9A563FA866493A5" modified="2013-09-18" version="1">MHIPSVLFSTLILSTASAFPTKTSNPERLFPRLLLRKLDTNADEHSLRFQPALDLDRDSCYHTAAIDRDGTVDKGLSELDGLLAKDCRDKSRLDNANVYTRKRCNNGWWAYMYDYYFEAHRTGSVHGKYHHRDNPLLQDGHPLIVYYKRPMTTDGLRFAKYKDVKNVKNRYWKWVIVDLVGWDRFPTPKFRHKLLKYNYGKARFHLADKHFSKGLHKAAGKHVPEFNPKKDGREEYDHNREKINIKKGKKDEDKLKDNEVKSVQGEQKEEEKGEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBC3</accession>
    <name>S0EBC3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434314.1">
        <property type="nucleotide sequence ID" value="XM_023581648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBC3"/>
    <dbReference type="STRING" id="1279085.S0EBC3"/>
    <dbReference type="GeneID" id="35407209"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13755"/>
    <dbReference type="HOGENOM" id="CLU_015320_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="181"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="390" mass="41903" checksum="C364214E75A80785" modified="2013-09-18" version="1">MTLYSTSNKFIEDVDPLKQAGQLPSYSIQPNSTEYQQPQPQPQDRDVSATAKPTAGERFHKISAKAGSPLNKAANLFGAEGWWPSTMDKECSKAARILHSFTNLNSSTSPTEKGPLHPTGLTRKSMVKIPPSVLQSAAGLAIFNVIRAGAGHNSLSGGSGVVIARRSDGTWSPPSSFIVSSLGAGFVFGLDVYDCVCVLNTPEQVAAFTKPRLSFGAEGSVALGPIGTGGSVEAALSKTARPIWSYMKSRGLWMGVQIDGTIVVTRGDANATFYNERGITAEKILCGDVAWPMAGKPLFEVLQALQGRTDYNQTVVQAVGQIPPPGDGILSEKQERYTDEPQAQETREQTQPVVTPRDVKEDLPDYEVVKKDDEEKIVDEEKARLAASGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBI9</accession>
    <name>S0EBI9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431873.1">
        <property type="nucleotide sequence ID" value="XM_023578952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBI9"/>
    <dbReference type="STRING" id="1279085.S0EBI9"/>
    <dbReference type="GeneID" id="35399188"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05709"/>
    <dbReference type="HOGENOM" id="CLU_2291783_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="101" mass="11753" checksum="3C5C0B52C5263C2A" modified="2013-09-18" version="1">MSTSVLSATCRSHIVSYKRPPGVGLGWGDFDRFYEWQLLGRKVQKSMVRAQRFQQSNSPHMTFISELTGCLHIVRTDSTKIESRRKLKRLNLWQKLKNGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBN4</accession>
    <name>S0EBN4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endosomal SPRY domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434387.1">
        <property type="nucleotide sequence ID" value="XM_023581735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBN4"/>
    <dbReference type="STRING" id="1279085.S0EBN4"/>
    <dbReference type="GeneID" id="35405618"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12162"/>
    <dbReference type="HOGENOM" id="CLU_038401_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43120" checksum="F662D5F46028AD57" modified="2013-09-18" version="1">MAPAIIRSLRSASSITQHAPRAAEAFSTLSGHLLEGSKVLLARDDKDDDKNDRHKPSVEPESGSFDPHDISNAGFFFLFALIGVAFVCTGIWFFFWAKNGGFQFKETDWDDYKSTVLRRTGPNGTILSNATRPTNLGGGSVYKDVDDDNTTVVTESTTLTGITAGASDIGAREKRRRKQEKRDRERAKKGKKTNRHVGEAGVEDEEAELAAKKELRSYRHERPARVGGLNKESEGSEWDGSTNPGTESNVSTNLLSDRQTTPTATPTKATGGIRKVYSTADRRENREAERMRAEARRLREAGRAARRDFSYQRAESYTRADSQVSESLLDGSQVTRTTDDSGDLGTKSYHHPMPELRELERERAREERRARRAQREYRRGRGEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBS2</accession>
    <name>S0EBS2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent protease (CrgA)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_08714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433311.1">
        <property type="nucleotide sequence ID" value="XM_023580553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBS2"/>
    <dbReference type="STRING" id="1279085.S0EBS2"/>
    <dbReference type="GeneID" id="35402190"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08714"/>
    <dbReference type="HOGENOM" id="CLU_013989_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="250"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="7">
        <location>
            <begin position="337"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT71232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="66948" checksum="C7096BDE0BC7A059" modified="2013-09-18" version="1">MSSEGTSQAAATDSASGPGPDAGPRQSRISDPPSDSEPPDSGRQPTQVTRSPSANTSRHRDVAPRDFVRLFQCQICSLPLDEPISLPCGKSLCRRCLPGTHMRANITYPAAPERLRGFKCPFEDCSKEHAVGDCAIDVVLNKTAQHVREEIERFMNESSTTELATKVMWPDPWAAAGVSSMRDDDEAYAKVIPGGKVIATYRLAEEGDLSYEADIYYDEITSATPSPPPDADDTGLVRKAQDATRAEMDCQVCYALFYDPLTTSCGHTFCRSCLHRILDHSRYCPICRRPLAISPLLSQTSSPSNQTIKRIIETFWLEEVNARKEALDAERVAQMQDYDLALFVCTLSFPQMPTFLHIFEPRYRLMIRRALEGDHTFGMVIPKRPQHPGDANFHQLGTLLRIVNVQFFPDGRSLIETVGLSRFRVLEHSYLDGYIVGKTERIDDVSLEDEEAAEAAEAAEATPIETEDQQQPIQAMDTVQEPTEPTPTSPLPRSDSSSPRMPTSITEIDSMSTQNLMHYASSFVTRMRQQSVPWLTERMLTIYGECPEDPAIFPWWFASMLPVKDIEKYRLLGTSSVRERLKICCTWIVEWETSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBW3</accession>
    <name>S0EBW3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431978.1">
        <property type="nucleotide sequence ID" value="XM_023579078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBW3"/>
    <dbReference type="GeneID" id="35399301"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05822"/>
    <dbReference type="HOGENOM" id="CLU_036637_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="305" mass="33922" checksum="6F275133E5965797" modified="2013-09-18" version="1">MFAAQNAGFDQRKRAREEEELANANGMSFSEHRNKRIQCLPLRAYPRTTEQWQPDAPMPAPSFAPHDHLQPEIRQWSSSTNMTSQSHGDTDMDMMQTYQPQHHDPGRLGVMHQDPDNANGRLPTPIQPSFAAQVRGQQAVTTPNGVANLGHQNTGFGDDQSVPRTMAGGWQAFQNERRLPSPISEGDDSMACQPITPTGMQFDANAHGFVTPGMEHPNVIVEPSPPHDVEHPMMDVESHCSGNSVDGDGDPTTPSPRRGHIRSRHTVNNWTWQPGMKKSFSIGYRADCEKCRLKVPGHFNHIIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC30</accession>
    <name>S0EC30_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_05879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432032.1">
        <property type="nucleotide sequence ID" value="XM_023579141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC30"/>
    <dbReference type="STRING" id="1279085.S0EC30"/>
    <dbReference type="GeneID" id="35399357"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05879"/>
    <dbReference type="HOGENOM" id="CLU_051542_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="94"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT69953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="276" mass="31350" checksum="90F5C7106E9F21D3" modified="2013-09-18" version="1">MLLSMDVMKVRDWTYLEDPPQDIGPARHLLEVYSKIPYNDLDGHIRRVREKAWCISQYPCVGRWKFLYIPDPKDPRYQQALFRLNVAGSRDVLLDLGCGVGQVIRQFRADGVDGAQLIGTDLQSKFIDVGYDLFQDRHSLNATFVAGDMLDPADKEMALLRGKITMVHAGSFFHLFNWVQQLYIGKRVVEFLKPGTKNALIYGRQVGTNHPGPSSTSTRSAYLHDQSSFQRLWDEVGALTKTRWQVQVEPTGEPVSKVPGFSNHAFPVNFTVYQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC81</accession>
    <name>S0EC81_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to NIT3 Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434619.1">
        <property type="nucleotide sequence ID" value="XM_023582023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC81"/>
    <dbReference type="STRING" id="1279085.S0EC81"/>
    <dbReference type="GeneID" id="35405875"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12419"/>
    <dbReference type="HOGENOM" id="CLU_030130_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="294" mass="32482" checksum="C7A33DFBFBA1FCEE" modified="2013-09-18" version="1">MAPIYKVAVIQFEPKAIVVEENFAKAESYLRSAASKGCDIAILPEFHLTSWVPEHPEFISASKASTGYLSKYQALAKELSINIVPGTICEVHSVPDSKDEELRNMAYFLAAATGEICGSYQKKNLWHPERPHLTSSTHTPHTAFDTPLKHADGRPVRAGMVICWDLAFPEAFKALVNDGADIILIPSYWFMDDNGEEGAGLNPDSERIFLNCTLTARAFENTAAIVFCNAGGLSCVNMPILGALGRIEVGEEKMEIVDLDLDVLRVAEETYKIRMDMKSEGWHYKYNMNSGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC98</accession>
    <name>S0EC98_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432087.1">
        <property type="nucleotide sequence ID" value="XM_023579209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC98"/>
    <dbReference type="GeneID" id="35399419"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05941"/>
    <dbReference type="HOGENOM" id="CLU_093221_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="313" mass="36937" checksum="A35B75C2FB3C1CB8" modified="2013-09-18" version="1">MAYTNPSQHRKFSSFGHTHNLVTSIMFSVLLNTEQVILATMGSDIHKLIGPKIVSFFPERASRSEDDYRSIEAMIYMGGSHMPRPGLYQVFEQLHRTRFQDRNHRLRQMSVTKDTFLTHNMVIPKPVPSQFGYPHGYDLISLDLHLVASTFDYEEAIPHIQLTDYAWRPLSLKTFPHLEEFTMMCLRPTSCRDQSHLPFLNSSTNRRGEYYGFRYHQDTRRVEYTRLIWSDVAELASAGEDLTNGLFPYTIVRLWIVGQRRGRYRMPRELEWTHLDLYPKSSERYLGRIRDLWVLTRIRLENPIRDETCQMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDA2</accession>
    <name>S0EDA2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_08074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433896.1">
        <property type="nucleotide sequence ID" value="XM_023581266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDA2"/>
    <dbReference type="STRING" id="1279085.S0EDA2"/>
    <dbReference type="GeneID" id="35401551"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08074"/>
    <dbReference type="HOGENOM" id="CLU_021555_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT71817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="572" mass="62241" checksum="F8026E2D22F4C93E" modified="2013-09-18" version="1">MQSDGSDTKNGFGVTSDSEPAHVGAVRRRRFGFNFSLEVDQEPSSFAPSKNLSNADFDPIPPSKRTWNWGAYVAYWMADAWAVSNWEVASSMIAVGLSWRMAIGACVLGNFLMGLVITCNGRIGAILHTPFPVLSRMPFGYYFSYFVVLSRCVLAIVWLGVQTTTGGQCMTVLLTAIWPSFANIPNHIPESEGITTAGMCGFVLYFLLQLPFLCIPYTKVQYFFAFKSIIAPIVFLAVFGDTLHKAGGTISHSTVISKGTTIHGATLAWAFFNNLNGVLGNYSTLGLNIADFSRYANKPSAQNVQAIVIPFIFTIVGLLGIFTAAASQSAYGEVLWNPIDIINLWMKSGSSGGRAAAAFAAIGLIIVTLGINISANSISAANDLMAFAPRYINIRRGQILAAIIGSWAFVPWKILASAQKFIAFLNGYTIFLGPMTSILMTDYYILRRGKVSVPDMYDFHGIYRYSQKWGSNWRAVVAFFIGCTPPLPGFIDNIVQAGGGHTGVSLGGQHLFYIGYIYSFLSAGVFYYLLNHFFPAPESMVEFAITGEDIIAAQDAKNLEIKQAGFASKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDX4</accession>
    <name>S0EDX4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="4">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FFUJ_06585</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Mg(2+)(out) + ATP + H2O = Mg(2+)(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="4"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432677.1">
        <property type="nucleotide sequence ID" value="XM_023579926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDX4"/>
    <dbReference type="STRING" id="1279085.S0EDX4"/>
    <dbReference type="GeneID" id="35400062"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06585"/>
    <dbReference type="HOGENOM" id="CLU_002360_6_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="783"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCT70598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="916" mass="100655" checksum="9E272D6E7C33AF86" modified="2013-09-18" version="1">MARRDTNILGRLGLRNGKSRARTATWQLNPDRATKSTPEDILRWIASMTPDTALAHLVSSSDGISEAEATARKRIHGQNVVSSRKPQSWFMLLLSVIPNPFNILLMFLAILNVAMPDPSWEGFAVLMVMIVISVAVRFWQEFQSGVAIFRLQSAIIPKIRVRRPATYTDELQLSWTEGTVLETDLVPGDIVILVPGAIVPADCLILESSYLRISQSAWTGESEPVGKDAGPHDAKEAFSIFDFSNVALMGTNIVSGHGVGLVVRTGDDAMIATMVKEVEKKRQPNAFQKGILNVTWMLIGFMIVMVPIVLCISGKVTGDWKNAALFSISVAVGLVPEMLPAIVNANLARAAHQLSKKQAIVKRLDSVQNLGAMTVLCSDKTGTLTKDELSVHKYSNAEGEDVLNIMELAKVDSQIQGNSGNNMDRAILNYHLPNGDEVGVAHYEQVRVIPFDFERRRSGCIVRGITGQYLLIVKGAFDEVLTRCSSMRSAGKSEYLSTEMQSRWRKLAMQKNMEGYRVLLVASRILGKSHVNELDLLETNMTLEGMISFSDPPKDDAKDAIASLTELGVQVKVLTGDSLPVALNICRSLELLQHSETMDDDAEAISGPELALLEDSDEFDLAVERCSVFAKVTPKQKSLIVLALQKAGNCVGMLGDGINDCGALRDADVGISVDSGAGVAKDCADLILTEKGLSIIVRSVILGRITHGNTIKYIKMVASSNFGNVFSILAASAWLPFTPMTSIQLLAQNLLYDISQIAIPWDRVDEEYLTQPRRWNARDILKFIIVLGPTSSVIDMCTFSLNWFFYGIRTTDDNVKLAQTHWFLQGLLTQTMIVHLLRTAKIPFIQSRAAPILVFSTASIMAIGFVLPWIPAFRPAFSFAQPAPTFVGFLAAELVLYAVEVQVVKMIYMKIFGTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEY6</accession>
    <name>S0EEY6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435402.1">
        <property type="nucleotide sequence ID" value="XM_023568046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEY6"/>
    <dbReference type="GeneID" id="35403457"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09990"/>
    <dbReference type="HOGENOM" id="CLU_1669524_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17857" checksum="E46078893BECF54E" modified="2013-09-18" version="1">MDYHALLHSQIYDYFLSSGMYSCGQALLNSDYNLRHQVMHAAAQRCTNEPRNATLSLLDSGFGSSYSSPYEEQCLTEPVDLSKAETEPALYQWFCTFWDALNSTQAHATSIPVQDSYLSYPPDLPQHLPESDSTINPDCLGLLSILLSHHLRKWRASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF95</accession>
    <name>S0EF95_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433107.1">
        <property type="nucleotide sequence ID" value="XM_023580307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF95"/>
    <dbReference type="STRING" id="1279085.S0EF95"/>
    <dbReference type="GeneID" id="35402411"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08937"/>
    <dbReference type="HOGENOM" id="CLU_826531_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="336" mass="35647" checksum="099064B29BD6BB8C" modified="2013-09-18" version="1">MSTSSSPLDLEQDSQPPQAVQEYLAQDTEQDHAASCSPPPEDRELWGTPPSTPLSPSSSPSSSPSSSPSPNVNGNKPLALPAVAPSAAAETVFPKEDNTMPQPQESQFDPAAAANEALNSVSLELEEASKPKQSRAAAKREPRQSRAAVKRDTAPKRVSKRAAKPPKLLTPNKLMQQMDKESFGLLLPVWSAKWAADKAAKAQAPVYGVPGQPYGQNPSQAAPGLYPPAPGQYSQATGPLYQQTPSLPPPAPAFPPAFAPAPAPAWVPTPSPHLPSAPQIPFLPQAPNYSIGLGIYNGLGQYHSAAPQPWLMQQPGLPDAFVELDEFDELDEFVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFH3</accession>
    <name>S0EFH3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to tetracycline resistance proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_09766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435518.1">
        <property type="nucleotide sequence ID" value="XM_023568295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFH3"/>
    <dbReference type="GeneID" id="35403233"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09766"/>
    <dbReference type="HOGENOM" id="CLU_021993_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="61"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT73440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="474" mass="51647" checksum="0DD714F9FDDC9A54" modified="2013-09-18" version="1">MNPNSKSCQIEQSQQRNHDDDLEEKLGSVEAVQQPETRTNDSGESINELEHWNSPRVNLYRYYATNFSFLIMGMNDASLGALLPYIETYYGINYTTVSTLFLVPVAGYVVAALTNNWIHYTLGQRGVAVLGPLCRLIAYIPVALHPPFPALPCVMLFTGFGNGIQDSGYNAWIGNMHRANELLGFLHGAYGLGGTIGPLTASAMVTEGKLNWYTFYYIMIGLAVVELVVGTSAFWGATGQVYRQRVRYDEAKERATTRMALKKPITWIVAVFLLGYVATEVSLGGWIVTFMLRVRHAKPFLAGLTVTLFWLGLTLGRVVLGFVTERTGEKTAITVYLVLSIGLELLYWLVPNFVASVIFVMLLGFFLGPLFPAAMVAATKLLPADYHVSAIGFAAAVGGGGAAVGPFAVGAIAQKTGVQVLQPIIVGLLGAITLIWLLLPGGFRKGGLERAREQNLRPGGDVKEAWLWVKSKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFN1</accession>
    <name>S0EFN1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to serum paraoxonase/arylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435889.1">
        <property type="nucleotide sequence ID" value="XM_023568738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFN1"/>
    <dbReference type="GeneID" id="35402836"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09367"/>
    <dbReference type="HOGENOM" id="CLU_033924_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF20">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="402" mass="44908" checksum="4E283D1D3AEFB4CB" modified="2013-09-18" version="1">MSNFLKMASLLIKISIAATALLAILFQIYLKEAIWLGFGINRTIQPLSEFPYRCRKIVHRQLEACEDMYLSQSTRQLFLACSDPIARKQWQPNVGYRNISGRSHRDAIVALDIDKPIDNGFTFRALRTPDFEGTSGDGLINLAGFSGVEQKNGDIDLFLVNLRPSIDVDGNLADQHVHGGNATIEHFVTGPQATEMKHVWTYVHHGITTPNRVAALSDKSFYISNDHGPHKIGWRHHLSMILGFSDVTFCDTQNCRPVAPNLQFPNGLVIKDNILYLPDSITGRLYIYRILPNKDLERIDEVNLGYGVDNASIDENGDIWIAAFPIGVEIFKAYDDPYHAHPPSAVLRARKIEGEYVVEKILEDAEGEVLPAATTVVHDTKTGRLFLSSVISPFIAVCEPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGK6</accession>
    <name>S0EGK6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435035.1">
        <property type="nucleotide sequence ID" value="XM_023582510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGK6"/>
    <dbReference type="GeneID" id="35406311"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12855"/>
    <dbReference type="HOGENOM" id="CLU_1777514_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="139" mass="16313" checksum="E879C49709D2A0B5" modified="2013-09-18" version="1">MADEIDTLIRHRVDRLESTVQILVKWTDDDIPQSWEREDFIQKIDPQALYTYWEDLGGRKEVTGLQLYHIFKVKAKGWAKGEIRYHCQWVGYSPKEDRWEPEEKVVNYAPAALADWKVREAARRARVAARKAAAQADNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="6">Related to parasitic phase-specific protein PSP-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCT74181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436259.1">
        <property type="nucleotide sequence ID" value="XM_023568981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGN5"/>
    <dbReference type="STRING" id="1279085.S0EGN5"/>
    <dbReference type="GeneID" id="35403688"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10223"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT74181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="308" mass="34196" checksum="9A604C2A85E85FF1" modified="2013-09-18" version="1">MNDTGNFVIFGPKANCTLELCPIEMSVYGYRPSLPANITFAALFTFATFAHAYLGFKWKTPWFMWCMILSCTHEVTGYIARILLWINPWSFGAFITQIIAITQAPVFYCAAIYVTLGQSIEHYGPSLARFPTKYFAWVFVPMDIISLILQGTGGGLSASSSGASQVGVDVAMAGLILQVIMLVAFSLLFGDYMFRYLRSKKSRNLGSRDKLFFAFLAIAVLATLARCIFRADELKEGYQGELIKHEDLFVALEGVLIVVAVFCLFIAHPGFVFNRPAKVYYSVATGTEATDEMAYRSKLADPVSESEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGR9</accession>
    <name>S0EGR9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436304.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGR9"/>
    <dbReference type="GeneID" id="35403734"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10269"/>
    <dbReference type="HOGENOM" id="CLU_057547_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="276" mass="30062" checksum="578FC282C885738D" modified="2013-09-18" version="1">MKSWFLAPDFTFTPDGPLRLGAVIPHPSRPTQTLASPRTDAITLPEVQTLVETNHSHSNDVTRTAGVNLFAKFVELASASIGYETSRRNALAYGTVDHEIRSLAAPFTREFLQSIISTEAVQEHIHSAVFGKRTVYFVSGLRVATSSFTVTKEKGIGHNTSLSGSGPAGPVPIEVGAGISSGKESSKTDSYETAPGIIFAYRLHAIRVRGSGTVDSEMFVNKKAFMHGRPVPDPEPFEVTDVDAEVLKADRKEEEDLPKYEMEDLGDEEYCFLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGU0</accession>
    <name>S0EGU0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to diadenosine hexaphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433667.1">
        <property type="nucleotide sequence ID" value="XM_023580989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGU0"/>
    <dbReference type="STRING" id="1279085.S0EGU0"/>
    <dbReference type="GeneID" id="35401799"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08323"/>
    <dbReference type="HOGENOM" id="CLU_1246069_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="98"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="231" mass="26041" checksum="D7917AF000AC172D" modified="2013-09-18" version="1">MSSSASGDSGGGRSMESRVGRSKQRESLPDAQYNVFSLKVSFSAHLTSLAFYESICLGVFYTILVAHFCGVMDLNPTTISYARLGTIGQLSDSYNTKGERLVAGIVPLTPDQNYVLLIQSTRRKGWVLPKGGWESDETCQEAAEREAWEEAGITVQITYDLGDIDEKRAPKSSKDRSRYHFFEGTVTSEYDDWPESHKRERQWFTFAQAWEALSTRPELQEALQRSTVNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHI6</accession>
    <name>S0EHI6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436153.1">
        <property type="nucleotide sequence ID" value="XM_023568251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHI6"/>
    <dbReference type="GeneID" id="35403273"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09806"/>
    <dbReference type="HOGENOM" id="CLU_1402553_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="194" mass="21916" checksum="60ED146E35B4D4A3" modified="2013-09-18" version="1">MDLFITAQEPFAHHPLKAKSFPSALSNSTDNPSSDARPLVPLPPVSQLEFDLIVHDPCHDSTLTGSWDPLPTPLSIPLNTSRVHLLNLLREKLPVVEASGKNRLSRQVRRPKLISATLYWTYGGKIYPLGPSDKEWHYRDLVTKTDIMARSELEWFLLKEMMASSRGALKCYISVRGEHLPAKKTSGWWFKNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHN1</accession>
    <name>S0EHN1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436594.1">
        <property type="nucleotide sequence ID" value="XM_023569370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHN1"/>
    <dbReference type="STRING" id="1279085.S0EHN1"/>
    <dbReference type="GeneID" id="35404035"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10571"/>
    <dbReference type="HOGENOM" id="CLU_055491_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF31">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT74516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="142" mass="15492" checksum="C18167D1BC0CE51E" modified="2013-09-18" version="1">MPAPYSGKCLCGNVKFATSSEPVTVLSCFCEHCCIGAGGTHQLIGKFIAQDVKVSTTADDAITKYSLSDTSSGSSKEKAFCRTCGCTLWTIPAAAKGKFYMIRLPLLDQGLNFQPANEIFVRNRPTWVEPVKDAGQWDEMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI00</accession>
    <name>S0EI00_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to ankyrin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436497.1">
        <property type="nucleotide sequence ID" value="XM_023569257.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EI00"/>
    <dbReference type="GeneID" id="35403934"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10469"/>
    <dbReference type="HOGENOM" id="CLU_001048_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="270"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="697"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="730"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="861"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="893"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="925"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="958"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1619"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1652"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1772"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1807"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1929"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2025"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2058"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2091"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1094"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1373"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2463"/>
            <end position="2502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1095"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1383"/>
            <end position="1397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT74419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2502" mass="278886" checksum="3A334B1F93171C41" modified="2013-09-18" version="1">MATQMPPPSHASVQSLWDQAFNSLGADLKTSLGQAATHKRDILAAALEAAETRKATSLRKRWKFKRSNGEVVIIRDVLEKIAKWIDSFKAVGDAAVQFDASNASLPWAAVRLLLQVTVNDVQQYGTMIQDLEVVSRIIARYKEFENLHLGRDEHAQPALETALTACLQPRQGRSSLTRAVRLAKSVFWTGDDGIRKILSREDEVLKLAKLQDTSDLRFIQKTVLRLRDQINNNTKRVEEDDYIKMISWMSTSPFSIHHETISDSRTPNFGQWLLKHEAYRNWCESSSSSTLWIHGITGSGKTSLFSVIVDSLRATWASQPESTPFAYFYCLKSESEPERSSADGSLHSILRQLAITETQSDVRDFFYSDFQRRSRSALLQGLDLPKMSRKECVDRIVQVANEDPITILLDGVEQVEDESSDILLQCLSDIISRAENVVKVLNTSRNSLDILSSLPTAKEIIVTADLVHDDMAQFIIQKIDDTKLISGRLSPDKRSCLTKELLEGAGEMFLWVHRQIHQLRKVKNEHDLLPALRSNILSDLDMLEFILRTKQCLFSASVAHSLLASTCIKVSARGPPDSGSLEQQVRGFFFYSATHWAGQFESSRVVKKEDKLFQDMISFVFEDEDYDVSLSFEAWLDTAKEIARLLPRDHPMKPALDAIPNATSSPLFLAAVFGIDGLLNLIAESESDIDWDQQNGLGHTALYLAAATGHLSTVTALIDKGAKQDVECGTYGSPLHVACFRGYQDIAEELLQHGASPQCGSKFQSAIQAASQGGHEDIVLSLIRHDIINSEDDYEQAMQMATEYGFIKVIDQLLKPEFNHFVEKDTPDKHKMRLAKAIKAGQLFVLQRQIAKAPPGAADTFPKDAVAIAALYGHTDMVKYLLEQGLDIEAEGQFGTPLRSACLMNHKSTVEELLKRGANINTEERKGNALYVAAAKGHKDIVRILLDEDADLHQKTGSCGTALHAAAYHGHRKVVEMLLDAGANVHVEGSSPDAFHAAAEGGHQNIIMLFLERGYRFLYEPPSPKYRRAQPSPYRPLYREVSPGRDKHPRSKLWPHLWKRAAGTAEPGSDTGARDNITRVETDDEMEMIAIDQRNSLRDDENRQDGYRKNRPLTASAARGRDAVVVILLRQKETLGFMDYEVDAALKAAASNGHLNTVRILLDHALKMKGPFIQRIYSTLENIPEGRHDILQLTLAKALESGCTEEQIDQLRLKLPPGKERYKVAVMEQQVLEADLLECCTSGNVSVLEAIMNCKHQQLLQANELLEGLQKATERGHISVIKSLFKLSSHLQRAGIPDDTLISAAGKDLEILKFLLSQKVDVSKSEFLLSRLIYTACSKGQPEIIEYLISNFGIDVNANIPEDEKPRRFRRMRQSADPRLTSAHITTTDGADGSTPTNDSRLVSLLQVSLGAFDTYEMPYYARWYRDKIMPQQQKTIQTLLRLGADPNSLGGKDVYPLPYAARICPGVVVKDLLEAGADVKLAGQGDLALLGAVQREMEAMAVMNRLLDNGHPLPDYFDRGKALLDKVLKFFEGDRGRQTFHSIIDDPDGRFEQAPSLEYIFEQGPGAIPEFLLQKYDTGKLEDTRYGLVLQMACVLGKAPLVELLLSRGVGVDATGYYYGSSLQAAARTGQLQIAKKLLDKGANPNVIQGRWHTSLHAAIVGGYLEIVQLLLQHGADPKLQFRIERQSHSERGLASSSTLQLALQEGHTEIARLLLDTDPSLVQEEGRLQHPLIISCQKGDDAMTELLLEANAPFNVRGHKEANVASMEVQDASPLHAAISGRHVNVVKALLLRGADANLEVDDCDCQTPLLAAIQRGDLRIIRLLLDSGAKLDSYSLQKACRSGDLAIVEALLEQLFNDGEGPFEIIDETLDSLIMEKFTDYRTLNLVLDYVPPTPKRFLLVCSSGSVPLVRRMIQQGISVDGSDEEEDSPLQVACYYLNFEVVRLLLQRGANVRSRSSQPGDPITLALWACALPLQQQLEQRGTRHQKYRAESADYRSIQRCTSIVRILLECGATPDGGTHEMESPLQLASFIGNLEIFKLLIKNGASVDKITGSFKTPLFSALQGNNSDIISLILEKGVDVNYVHPIHGSALHLACQYNNEPAVLQLLQHGASPALKNANRVTALTLALESAASYYGASQNISRLICRHSTTLDITDSDIIAAARVEPSDLLSFLLDRRGEEPVTEDLVIRFLSEERRPSQENLEVLFDRNQGLEITPKMLNVGLSEQAFRSLTQARQLSVDITPDMLESQTDLGTLKALIGYQPDVEVTEGLVIKILSIVPRYSRWWQREESTELLLSLWPRDLPLSVTNAMLKAATSLPHLEFLLERLGSAQGQLQDVAVWICEQGTDYSGTRDNMLALVLKVDPKVDLSLCHLEKIMVGAKPLMLDMVLTHTPSLPITETLFLSIFREYPDALEYTRKEFAEVLIRHKKKFVFTEKIREAIDTAYQKHSDMDKRDTWYNLRERDESQEEAEARQAEENDGNKNGDHDHPRDNMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJS1</accession>
    <name>S0EJS1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437329.1">
        <property type="nucleotide sequence ID" value="XM_023570180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJS1"/>
    <dbReference type="STRING" id="1279085.S0EJS1"/>
    <dbReference type="GeneID" id="35404760"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11298"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="324" mass="35524" checksum="B669A175F5895050" modified="2013-09-18" version="1">MDPVRPRSRDEFKVALICALPLEANSVLSLFDHHWDEDDGNPRIGKARGDPNSYSIGIMSGHRVVLAHPPGIGIIAAGTIAAFCKLSFTSIRLALVIGICGGAPVNNGIQIHLGDVIISTGIVSYDFGRRFSDRFEMKDTSSEVPGRPNLEIRGLLSKLATTRQTGRLRSAIYSILYQLHQGSDTALQYPGTSKDILFPANYRHKHHEPSKCAICAVCRAKSDPVCAAATVSDCHDLKCNTRKQLSRPRLTGSHQLFPSPNVHFGIFASGNSVIKSGEERDRLNEDKNAIGFEMESAGVWDIFPCIVIKGVCDYADSHKNKEWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKN8</accession>
    <name>S0EKN8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to alpha-glucoside transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_11204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437243.1">
        <property type="nucleotide sequence ID" value="XM_023570075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKN8"/>
    <dbReference type="GeneID" id="35404667"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11204"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF57">
        <property type="entry name" value="MALTOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="66"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="539" mass="59747" checksum="FE874773A58729ED" modified="2013-09-18" version="1">MGISEKEEPVSAAEIETQKHTINHQADLDHKAEIAQFKGDAIEAENAEFNMGVLEAVRAYPMATLWAFIMSCTIIMESYCVFLMGNFIALPKFAQDYGVYSANVNKYVITGPWQSALQCCGPVGALIGVTIAGPITSRIGYRWATIGGLMLLNAFIFVFFFANSLSVMVAAQVLEGIPWGIFIANAPAYCSEIVPMRLRAPATQMLQMFWAIGSIIVNGVAYHYNGLEEKAAYRVPIALQWMFPTPLAILIFLAPESPWWLTRRGRYEDAVKAVARLGRSTVVKNHEESVAMMRRTIELEKSEKEPSYLELFKGTDRYRTLIVCGVYAAQNLTGNLIANQATYFFEQAGMTTNTAFALGLITSALQMIFVMLSWILTTYIGRRTIYVWGSFINVLFLLALGIAGSVGKSNAASLAQASLGLIVSVLFTLGPAPVSYAIIGETSAIRLRPLTTGIGRASYYLVNIPCIFLSSYMLNPKEANLGGRCGYVWAGTGFVCFLMSWIWLPEFKGRSYREIDILFNRRVQARKWSKTVIDPNDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKQ7</accession>
    <name>S0EKQ7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to calcium-independent phospholipase A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_11590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437609.1">
        <property type="nucleotide sequence ID" value="XM_023570505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKQ7"/>
    <dbReference type="STRING" id="1279085.S0EKQ7"/>
    <dbReference type="GeneID" id="35405051"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11590"/>
    <dbReference type="HOGENOM" id="CLU_003208_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="11"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="55"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="204"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT75563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1273" mass="142435" checksum="2E40428313E5EB18" modified="2013-09-18" version="1">MANNPTGLRILSLDGGGVKGYGSLLILRRIFRTMVTEGGLEKEPLPCEVFDLIVGTSTGGLIAIMLGRLRLSIDECLLQYEKTGKAVFDKPISQNKLGKMFKKATSSALYDIDKLQEEIRVLLGSCSMEPDCPFVEDGSGSPCRVMVCVTRGINSRPDVLRSYMSSHPTQENYKCSIWEAASATAAAPTFFDPVKLAGGESFCDGGMRRNNPINETVNELNRELERGWSGRSLGCLISVGTGVVEAAKISTSVTTLIRAVVKILTDSEDTAEEFVKSPFGRQLESSGRYFRFNVPQGLQTLKLDEWMETEKLNAATTEYLSKSGTGNLVKLCAQALNDPDALLNMPLFSNRQLRLDNPCNNFVQRPLYQSRLREYFWNFNSTKPQIFVLWGLAGVGKTQLALKFAEMMKTRLKVFWVPADQPSNFNQAYAKLLAQIQPGHQLANATQDLPTLLEETCSQLEASPASWLLVIDNADDFDEYQQAMDPYLPRSGRILITSRDPRFQGDVAAVEDGMNVLPMEEEESIELLTKSIPGRLLKMPTETEEAPSYLVNMLGNLPLAIAQAAANIRDQQVPLRDYIKFFQDEMDPSSSFRVPARDRNARDPRNAEQSVSKTWGVSLNRLRESSPPTVLLLGYMSCLHWDSIPVDLIRQLPKFMGFSPIEFRQMIAAGLQLSLVQEHDLGQFSVLQMHPLVHGYAWSQVGSTDSKFVEEIVSLLCVTFPLTTSHSSDSPDWVLSAFLSSHCRRAITVSENVSLQSKQLARLMQVYSSYLNEFGDLKSALVISTRALDLATAMWGPHDISTFHVSKTRIDCLQSSQMHQKALEDIDGGLEYLNSGRHGLMETEVERLGEVVDLLCTKRTIFSDLVNHQAALEVDIQAVNILTEIRKMEPQSLPVESALLVALHNKAHSLHRLARLDEAEALNLEVLKDSLGSDGSIKVDQSSYHAFLNLRGQIVADKENASPNQHVEALKIFSLVFQDTLETHGIGSRDTWIAANNVLSELAALDGDSRVQLTSLELFELLFSLVSKQGLPQRANHPEFQYALWSFLGRLNDSLELLQSPDFERLWGMRTEFVKVCQMTQEIPSLYTASRANAAGVMLQARGRFELAEARHREALDILNTMPGEALAAKNARDLFNVSHYNIMLALARQGRVYEARIYRDEHRSDIFTAEETYDSLEVRLDRDLKDKNVYDQTVAMMASGDLSPTDQWWLDHATSLQRAQKRYGSFIKPSATADIAEPQLLGDVKRILTFPKTIKKMKNVFPFKRRKLPKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELE3</accession>
    <name>S0ELE3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437904.1">
        <property type="nucleotide sequence ID" value="XM_023570852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELE3"/>
    <dbReference type="GeneID" id="35405362"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11902"/>
    <dbReference type="HOGENOM" id="CLU_598579_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="457" mass="49810" checksum="8BF446E230C53B76" modified="2013-09-18" version="1">MRIDNTRARPSTRDTQPSLQGQPVSSSRQRHRTISSSSDADSTTAIWGSPEESRISNSPDILPSMTQEECTQPYSNYQPSIGFQQNVVPQSPSWQTSPVQQQAYYQTYTTSNPGPSLTTTSGQGDSTDYTSTESSEDEHVDELRSPYWGSRRQFRDALASASTRSDINFAPRRRSHYQPASRSAVDETTANPSLMTERPSSSRHRRPSSNTTNTAAGSSRPPRIGGPVLPSPADRLPQHMVAPIHSHPFRPWTPIPPPSVLNAPAYDFSQVIYPSQSYAGYGQSGPSEYQYSTGGAPPNIEAIRPRIQLGINQSNQERGPVGSDSGIHMSGISAGYLQQPHGQRESTPHTLVNASQNAIPRWMPTPLLGSHTTQSASRSPVSHQQVAARGAQRQSETSPQLGDVNTEAGRSVLPTGHIEQPSGQRGGNPSPLRTEAYGTSGQGREPPRGMRRRRQQD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-10-10" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELQ3</accession>
    <name>GPY2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter GPY2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gibepyrone A biosynthetic cluster protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GPY2</name>
        <name type="ORF">FFUJ_12021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="J. Biol. Chem." volume="291" first="27403" last="27420">
            <title>Gibepyrone biosynthesis in the rice pathogen Fusarium fujikuroi is facilitated by a small polyketide synthase gene cluster.</title>
            <authorList>
                <person name="Janevska S."/>
                <person name="Arndt B."/>
                <person name="Niehaus E.M."/>
                <person name="Burkhardt I."/>
                <person name="Roesler S.M."/>
                <person name="Brock N.L."/>
                <person name="Humpf H.U."/>
                <person name="Dickschat J.S."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="27856636"/>
            <dbReference type="DOI" id="10.1074/jbc.M116.753053"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">ABC transporter; part of the gene cluster that mediates the biosynthesis of gibepyrone A, a 2H-pyran-2-one metabolite exhibiting a moderate antimicrobial activity against Gram-positive bacteria and yeasts (PubMed:27856636). GPY2 seems to have a minor impact on the efflux of gibepyrone A out of the cell, but it was shown to repress expression of the key gene GPY1 (PubMed:27856636).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Members of the velvet complex, VEL1, VEL2, and LAE1, negatively affect GPY2 gene expression and gibepyrone A product formation, whereas SGE1 represents a positive regulator of gibepyrone biosynthesis.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Results in a significantly enhanced level of extracellular gibepyrone A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELQ3"/>
    <dbReference type="SMR" id="S0ELQ3"/>
    <dbReference type="STRING" id="1279085.S0ELQ3"/>
    <dbReference type="GlyCosmos" id="S0ELQ3">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CCT75968">
        <property type="protein sequence ID" value="CCT75968"/>
        <property type="gene ID" value="FFUJ_12021"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12021"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000445365" description="ABC transporter GPY2">
        <location>
            <begin position="1"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="997"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="1021"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="1107"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="1136"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1 1" evidence="3">
        <location>
            <begin position="279"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="2">
        <location>
            <begin position="601"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1 2" evidence="3">
        <location>
            <begin position="882"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="2">
        <location>
            <begin position="1197"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="635"/>
            <end position="642"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="677"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="1130"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="27856636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="27856636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1432" mass="157247" checksum="9ED388E3AEEFFE44" modified="2013-09-18" version="1">MPPPNCLLHVEDTFGPVVKGCGSNFDFTLLFEETILCILPLCVAICLAIFRVTRLWKKPVIFKGCFILPLKLIAWNLVLGSQASVVALFSIRDETRTRASIAAGSIGIVGSAILACLSFLEHQRAVRTSSILVLYLLSTIPMDAARARTLWRMLDGRDPAIAVMVLGATKVCALVTEMLWKCSLANRHELCDAPEESNGIIERALMLRMMPIFWAGYRTPLQTEHLSKLDTKLQNAELRPSEKGPKRKQAPIKLAKEIFFSHTYEFLAPIFPRLCYLSLTFAQPFLVRRAIDYISKPKTEGSGERGDGLIAAYALVYYGIAFVSSLYEQSAVRATTVVRADLSMRIYQQSLLLDRVVDTGDSSTTMMTADVERVQLGVRKLHDAWASFVSVAIGLWLIEAQLGLAALVTLGLIGGSLLLGGYWSGRASRFQKNWMAAIEKRLHKTVQVLKGIKSIKQMGAAPAIKTMLEDERQSEIKLSKKFRLQLIALVTLSFTSLTMLPALGLSVHNAVSDKSSGRILTAQTAFQVMTLFNIVSSSIQDCTSHVMAIMVGLGSLQRIESFLNQHTWTDPRKSIRDASISTDESSVGGTSEKKVLTDVAVKIQNVSAKWTEDGEAIIRDATFDVPAHGLTVVAGPTGSGKSTLLRVVLGDLAPSSGTVSVDDSQVAFCDQTPWIANISIKENIVGALPFYEERYRMALHACALDQDIEDLTDGDKHLCGLNGQSVSGGQKVRIALARAIYSKATLVLLDDCLVGLDTNTERHILGEIFAPRGLLSSAPTTTILATSSPRYLPFANYIILIDADGRIVRQGTYAEIAPHIEQLEHDVLQVSDHAATAREPRAQDSDELPNTAITNDIAFKKGANGDWAVYKWYFGVIGWMDFVVFLFLCLGFVIGVIFPQIYLGLWSEKSLQNQIDTLPSFYGIFFGVGSMAWVALFSACVWLFLRIAVRTAALFHHLILTTTLNARMDFFSQTDSGVTLNRFSQDLQITDMELPLAFVGATMNLLMLIAQCIVVTIQSHYAGFAILAIAVVIGFFHEFYLRTSRRLRVMDIEARSPVLSLLLESLDGLATVRAYGWAAWYLRRGIEVLERSQVPFHFLQSAQVTLNLSVDLFVATLALVVISIAVVQMNTSGGSLGLALFNIVGLGQSVKGVVFFWTSLEITLGAVARIRDFTEDTKSEHESDTKPPVEWPSRGEIHFSDVTLTHSTSLPPTISNLTLDIKPGSKMAICGRTGSGKSTLVNSLLGLVQVSSGIITIDDVDISTLAKDEVRSRFVVLPQESLILSVSIREYAKLFGISDEQEIIQGLKKTGLWQTIEQGGGLDMIASSDTFSHGERQLFAMTLACLKKGKLVLMDEPTSHVDNDIQTQLRQAVFDTFPDSTVLCVTHQVATIVDFDIVLVLDDGKIVEQGDPKELLHQPTSRFAQLYSAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMC4</accession>
    <name>S0EMC4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437818.1">
        <property type="nucleotide sequence ID" value="XM_023570750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMC4"/>
    <dbReference type="STRING" id="1279085.S0EMC4"/>
    <dbReference type="GeneID" id="35405271"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11810"/>
    <dbReference type="HOGENOM" id="CLU_020019_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002:SF2">
        <property type="entry name" value="AQUAPORIN AQPAE.A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002">
        <property type="entry name" value="AQUAPORIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35243" checksum="1E8F79245BD50842" modified="2013-09-18" version="1">MAVTNRRKARDSGDVEARPSSEPSGPHYRSNSQPFAGRLGANQAYVVEGGTSEDDHLLHHAPDATPHMSFWELMDMSPIKNLDLWKAALIEGIGTLLFVYITIWVNISPDTAPAAPTQRFGSFDNAAFLGPLIGGITNLIFITLFITSFGAISGAHFNPLITFATFCARLCSLPRLILYVAAQLGGGALAGLLVRASWGGRDFKVGGCWLFTDIVPPREIFVVELVSSTLLLFLAFGVGLDPRQAKIIGPALGPFMVGLSVGTMSFASAFARYGYGGAGLNPARCMGAFVGSSFPSWHWIHWVADGTACIIHGVCYYFIPPWTEVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMD3</accession>
    <name>S0EMD3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to sterol glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_11113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437115.1">
        <property type="nucleotide sequence ID" value="XM_023569976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMD3"/>
    <dbReference type="STRING" id="1279085.S0EMD3"/>
    <dbReference type="GeneID" id="35404577"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11113"/>
    <dbReference type="HOGENOM" id="CLU_000537_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF27">
        <property type="entry name" value="GLUCOSYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="97"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="415"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT75037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="803" mass="86211" checksum="C2FE52A599A96444" modified="2013-09-18" version="1">MSKSRSQSPSKGKEAQDTDNVLDIPWDAPPPYELHSSGSVLASTSRVNDYGKVDIEFSSLQPDEVNRLLPPDKAQEIEPSSSFSTAAPSGPCPALNVVIQVVGSRGDVQPFIALGVALQRYGHRVRLATHDTFTDFVRSSGLEFYPVGGDPEDLMAYMVKNPGLIPSMESLRGGDIGRKRVMIHDMLRGFWSSCVKPDPVSNRPFVADAIIANPPSFAHVHCAQALGIPLHMMFTMPWTATKSFPHPLANIQSQNMDPRASNYLSYGVVDLMTWQGLGDVINAWRVKDLHLDPLAAAVGPDIVGLMKVPYTYCWSPALVPKPSDWGESIDICGFFMRDEPAYTPPQDLADFLARGPPPVYIGFGSIVIDDPTALTNIIKESCRVAGARVIISRGWSKLGGNDPSTNSVFYLGDCPHEWLFKRVAAVVHHGGAGTTACGLVNGRPTTIVPFFGDQPFWGSVVASNGAGPSPIAYKSISVDKLSSAIKFCLSPEAQAAANRIATQMREESGVNTAVDSFHRHLPVANLTCDLIPHNAAKWQYIGRSKKGDKGHIRLSNAALKVLLDAKKAKLADFEPLRPKGYLVENERWDPVTAGASSVLGTMTDFTSALGGAFIDPFKDVKRVRPDGTRRSAGTATAVASGKALQGMTTAVVKGSLVDVPLAFAEGFRNTPRLYGEKVADYGPVTDWKSGGTVAAKNFGFGFYEGLTDIVTKPMKGAKEEGALGFFKGVGKGSLNMVAKPGSATFGLLAYPAQGIYKRIQSMKTNKARDAVTAGRVESLSDGEQGATSPDAPQVVKRFQELIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN10</accession>
    <name>S0EN10_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438078.1">
        <property type="nucleotide sequence ID" value="XM_023571067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN10"/>
    <dbReference type="STRING" id="1279085.S0EN10"/>
    <dbReference type="GeneID" id="35405554"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12094"/>
    <dbReference type="HOGENOM" id="CLU_031555_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT76032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="27030" checksum="E5964E6EB6A2AE57" modified="2013-09-18" version="1">MLDGPFSEGIRSNDNFFEVKAFEWNAEALVILLDIIHGHHRCLPKDVELDILIELAMLCDYYRCEEIVEVFAERWIAAFGEDKPPYEDEATMNWIFIAWVFQKGKLFTSMVAATLQHRKIPMYTDLPLPSTIVEKVEAQRVKFINEVLNNLYGLQESLLVTNDDCKRECALMLLGSLMKQMREAGLEILEPNDLSSTVRSVVELRRFVSGLETPVWHLAGVLRAFMTKEDLGKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN18</accession>
    <name>S0EN18_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437380.1">
        <property type="nucleotide sequence ID" value="XM_023570240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN18"/>
    <dbReference type="STRING" id="1279085.S0EN18"/>
    <dbReference type="GeneID" id="35404814"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11352"/>
    <dbReference type="HOGENOM" id="CLU_010595_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="339" mass="38149" checksum="440A908796AE34D7" modified="2013-09-18" version="1">MAAPIEAEPALDVGNDTESNFSADSETESTASITSSIFENKYFQGRTYANPKYGKHWAPNDEEQLEALDLIHHWLTLMLDDKLFLPPIGDNPQKILDIGTGTGIWAINVADEYPSASVIATDITPTQPSFVPPNVEFQIDDAQLEWTFEPESFDFIHIRYLQGTIADWDKLYGQMYKALKPGGWFQHIEPDLQMLSQNPEIKVDDEHIFTRWAKIFTQVGETIGCTFDFSNGKLATLAKDAGFVSVTPQTHKVPIGRWPRDKKKKELGTFVGLSFSQALDGFVKLPLCEILKWSPEEMQLFAAEMRKVLMNPKTQAFGHVFSVYGQKPERPKESSPAAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-10-25" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN43</accession>
    <name>BEA1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beauvericin nonribosomal cyclodepsipeptide synthetase BEA1</fullName>
            <shortName evidence="1">BEAS</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beauvericin biosynthesis cluster protein 1</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Nonribosomal peptide synthetase</fullName>
                <ecNumber evidence="1">6.1.2.-</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">S-adenosyl-L-methionine-dependent N-methyltransferase</fullName>
                <ecNumber evidence="1">2.1.1.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">BEA1</name>
        <name evidence="9" type="synonym">NRPS22</name>
        <name type="ORF">FFUJ_09296</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="Fungal Genet. Biol." volume="75" first="20" last="29">
            <title>An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium.</title>
            <authorList>
                <person name="Hansen F.T."/>
                <person name="Gardiner D.M."/>
                <person name="Lysoee E."/>
                <person name="Fuertes P.R."/>
                <person name="Tudzynski B."/>
                <person name="Wiemann P."/>
                <person name="Sondergaard T.E."/>
                <person name="Giese H."/>
                <person name="Brodersen D.E."/>
                <person name="Soerensen J.L."/>
            </authorList>
            <dbReference type="PubMed" id="25543026"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2014.12.004"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2016" name="Environ. Microbiol." volume="18" first="4282" last="4302">
            <title>Sound of silence: the beauvericin cluster in Fusarium fujikuroi is controlled by cluster-specific and global regulators mediated by H3K27 modification.</title>
            <authorList>
                <person name="Niehaus E.M."/>
                <person name="Studt L."/>
                <person name="von Bargen K.W."/>
                <person name="Kummer W."/>
                <person name="Humpf H.U."/>
                <person name="Reuter G."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="27750383"/>
            <dbReference type="DOI" id="10.1111/1462-2920.13576"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2017" name="Toxins" volume="9" first="0" last="0">
            <title>Enniatin and beauvericin biosynthesis in Fusarium species: production profiles and structural determinant prediction.</title>
            <authorList>
                <person name="Liuzzi V.C."/>
                <person name="Mirabelli V."/>
                <person name="Cimmarusti M.T."/>
                <person name="Haidukowski M."/>
                <person name="Leslie J.F."/>
                <person name="Logrieco A.F."/>
                <person name="Caliandro R."/>
                <person name="Fanelli F."/>
                <person name="Mule G."/>
            </authorList>
            <dbReference type="PubMed" id="28125067"/>
            <dbReference type="DOI" id="10.3390/toxins9020045"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 6 7 8">Beauvericin nonribosomal cyclodepsipeptide synthetase; part of the gene cluster that mediates the biosynthesis of beauvericin (BEA), a non-ribosomal cyclic hexadepsipeptide that shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic activity (PubMed:25543026, PubMed:27750383, PubMed:28125067). Ketoisovalerate reductase BEA2 catalyzes the NADPH-specific reduction of ketoisovaleric acid to hydroxyisovalerate, a precursor for beauvericin biosynthesis (By similarity). The nonribosomal cyclodepsipeptide synthetase BEA1 then catalyzes the formation of beauvericin via condensation and cyclization of 3 dipeptidol monomers, each composed of one unit of hydroxyisovalerate and one unit of N-methyl-phenylalanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 (R)-2-hydroxy-3-methylbutanoate + 3 L-phenylalanine + 3 S-adenosyl-L-methionine + 6 ATP = beauvericin + 6 AMP + 3 S-adenosyl-L-homocysteine + 6 diphosphate + 6 H(+)</text>
            <dbReference type="Rhea" id="RHEA:62276"/>
            <dbReference type="ChEBI" id="CHEBI:3000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:145660"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:62277"/>
        </physiologicalReaction>
    </comment>
    <comment type="induction">
        <text evidence="7">Expression is highly repressed by the histone deacetylase HDA1 and the beauvericin cluster-specific repressor BEA4 (PubMed:27750383). BEA biosynthesis is also repressed by the activity of the H3K27 methyltransferase KMT6 (PubMed:27750383).</text>
    </comment>
    <comment type="domain">
        <text evidence="1 13">NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, additional domains required for further modifications are also present. Beauvericin synthetase has the C1-A1-T1-C2-A2-MT-T2a-T2b-C3 domain organization (PubMed:28125067). During catalysis, C3 and C2 take turns to incorporate the two biosynthetic precursors into the growing depsipeptide chain that swings between T1 and T2a/T2b with C3 cyclizing the chain when it reaches the full length.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="7">Leads to complete loss of beauvericin biosynthesis (PubMed:27750383).</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.2.-" evidence="1"/>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="S0EN43"/>
    <dbReference type="STRING" id="1279085.S0EN43"/>
    <dbReference type="EnsemblFungi" id="CCT73878">
        <property type="protein sequence ID" value="CCT73878"/>
        <property type="gene ID" value="FFUJ_09296"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09296"/>
    <dbReference type="HOGENOM" id="CLU_000022_60_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19531">
        <property type="entry name" value="LCL_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000084">
        <property type="entry name" value="Enniatin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000442145" description="Beauvericin nonribosomal cyclodepsipeptide synthetase BEA1">
        <location>
            <begin position="1"/>
            <end position="3135"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 1" evidence="4 13">
        <location>
            <begin position="1021"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 2" evidence="4 13">
        <location>
            <begin position="2509"/>
            <end position="2583"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 3" evidence="4 13">
        <location>
            <begin position="2603"/>
            <end position="2677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 1" evidence="3 13">
        <location>
            <begin position="70"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation 1" evidence="3 13">
        <location>
            <begin position="499"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 2" evidence="3 13">
        <location>
            <begin position="1115"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation 2" evidence="3 13">
        <location>
            <begin position="1571"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine-dependent N-methyltransferase" evidence="3 13">
        <location>
            <begin position="2042"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 3" evidence="3 13">
        <location>
            <begin position="2721"/>
            <end position="3127"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1058"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2543"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2637"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B6D9A8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="G3GBU6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="25543026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="27750383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="28125067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="23825955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="27750383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="28125067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12"/>
    <evidence type="ECO:0000305" key="13">
        <source>
            <dbReference type="PubMed" id="28125067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT73878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="3135" mass="346309" checksum="82A8B2E7B86EF1FC" modified="2013-09-18" version="1">MTSLNTKSGTPVVPLLLRSDDASHTDTLVEEVSCSLGLGRDRIENILPSTAFQQDVIDCAGSEKQRSIGHVAYEISNDIDISKLAAAWKDTINRTPALRTCAFTSSSGETYQVILKDSFVFSWMFSTSADQKDAVVKDEAAAAASGPRCNRFVLLDDPIQKKILIWTFSHALVDTSFQERILGRVLKAYTHGHDELSNRPYTPESSDPEDDGLSLTPTDGSKTPETEGLHPATQYWKNYLSDLNASAFPHLTSPLAVPYPNAKSEHRITFTASSSSTWPSVAVCRTALAILLSRYTHSQEALFGVVTEQQQLLVNGPTRTVVPFRVHCASDQSLSDIIDVVNANDDAIRQFADVGLRSISSTGDDGVAASGFQTVLLVTEGDNEQSSSTFEILQKTEESELFMPCTNRALLLHCQIASDGLSIIARYDKSLIHSQQIARLLRQLGQLIQRLRGSPDKLPSAGELDISTSEDQAEIQSWNSHPIPSQPTLIHKEMLKTASLSPSKVAICAWNGEWTYSELDNITSRLAALIKFSTPDQEHAILPIYFEKSKWVVASMLAVIKAGHAFALIDPNDPPARVSQVVGQTGATVALTSKLYRSKVQGIIERCIIVDDDLVQSLICTCALKPDPTLAKVTPEDLAYVIFTSGSTGDPKGIMIEHRAFSSCALQFGSALGINSDTRALQFGSHAFGACLLEIMTTLIHGGCVCIPSDDDRMNNVPAFVNRANVNWMMATPSYMGTFQPDDVPGLKTLVLVGEQMSPSVNAIWAPRVQVLDGYGQSESSSICFVGKISSSGADPNNIGHSVGAHSWIIDPSDPNRLVPIGAIGELVIESPGIARDYIIPPPTENSPFFSTVPPWYPFKELPNGIKFYRTGDLARYASDGTVVCLGRMDSQVKIRGQRVELGAVETHLRQQLPDDMSIVVEAVKPSDLPTSTVLVAFLITEATKSVRDATILDLAATKAMSVKLEHVLPRHSIPSCYISMQHLPRTATGKVDRRKLRSIGRDMLAQQLQGTSFRPSQLSSTTTSSQSKLEEVWRQCLGLEPGAANINSTFFELGGHSITAIKMVNMARSAGIDLKVSDIYQNPTLAGLEAIVNGSAEPYAIIPTTTRDGPVEQSYSQGRLWFLDQLEVGALWYLIPYAVRMRGLVDIDALSRALMALEQRHETLRTTFEDCDGAGVQIIHKILSKKLRVVDAPDSDYLDLLKQEQTTPFDLTSEAGWRALLIRLNDTDYILSIVMHHIVSDGWSIDVLRHDLSQLYAAALQGRDLASAMNPLPIQYSDFAMWQKQEAQALEHEKQLDYWKRQLADCSPAKLPTDFPRPALLSGEAGVVPVSIDRQLYQNLRDFCNENNTTSFAVLLAAFRAAHYRLTGVDDAVIGTPIANRNRWELENIIGFFVNTQCMRITVDDQDTFGSLVSQVRATTTAAFENEDVPFERVVSTMLPGSRDLSRTPLAQLIFAVHSQKDLGRFELQGLESEVVASKAYTRFDIEFHLFQEADGLRGSCNFATDLFRPETVENMVSVFFQILRNGLEKPNIPISVLPLTDGIEELRRLDLLRIKKVEYPRDASLVDIFRTQVAAYPDSLAVVDSSSRLTYTELDLQSDRLAARLRRQGMPAETLVGVLAPRSCEAIVAIIGILKANLAYLPFDVKSPSARLEDILSSIPGQTIVLLGSDVPVPELSIPGLEFMRIVDAIECCDTNNLNGHAHVDNSNPTATSLAYVLFTSGSTGRPKGVMVEHRVIVRLMTSNIIPDFPVQPRSAHMFNIAFDGATYEIFFTLLNGGTLVCIDYMTTLDVKALQDVFLKEKINAACMAPALLKLYLTDARDALRGLDFLMAAGDRFDGQDAIEAQSLVRGQCYNGYGPTENGIMSTRYPIAVGDSFINGVPIGRAVNNSGAYVTDLNQQLVGVGVMGELVVTGDGLARGYFDPALNENRFIHIEVDGQRVRAYRTGDRVRYRVGDGLIEFFGRMDTQFKIRGNRIESAEVEAAMLGHGSVRDAAVVVQKDDGEKADLVGFVVIDHDHSLEGDANDNQVEGWQDHFETEMYADIGDIDPFTIGKDFKGWTSMYDGSEIDKVEMQEWLDDTIKTLRDGQAPGHVLEVGTGSGMILFNLGDGLQSYRGLEPSKSAAAFTNSVIKSVPSLASKAEVHVGTAQDVSQLTDLHPDLVVINSVAQYFPSPEYLAQVADTLIHIPGVKRLFFGDMRTNATNKHFLAARAIRTLGDTATKDFVRQKMAELEEREEELLVEPAFFTALQDRFPDLVHHVEILPKNMHATNELSAYRYAAVVHIRDSDSVPVHTIEKSTWVDFGASRMDRTSLLQFLRRSKGSPTVAISNIPFAKTIFERQIVESLEAEDESKLDGAVWISAVGSDADSRASLSVPDLRRLAEEAGFRLEVSAARQWSQSGALDAVFHHLPSPSDTRRTLIKFPNDNHLRSSATLSNRPLQGLQRRRATLQVRERLQSLLPSYMIPSSIVVLDQMPLNPNGKVDRKELARQARIMPKQQTALPVQAVPISDIEAILCDEATATFGMKVDISDDFFKLGGHSLLATKLISRVEQRFNVRVTVKDVFDNPVFANLAVVIREGLASRTTLTNSQDKQGWSARVAPRTETEITLCDEASKLLGIEVGITDNFFDLGGHSMMATKLAMRLGRRLDTTIVVKDIFDYPVLFQLSKKLESTDSGTDNEEVQVDDYTPFELLSLENPQDFIQRQICSQLNVSLESIQDMYQSTQMQKSFLFSPGTGSPRPLTPFYIDFPVDSDPPTLVNACHSLVQHIDMFRTVFVLASEQLYQVVLKHLEVPIETIVTNQNVNTATNDFLVEHAQDPIRLGESLIRIAILKQSSSVRVLLRLSHALYDGLSLEPIVRNLHILFNGMSLLPPTQFRRYMEYTANSQEKGFEFWRDVIGDSPMTILSDAGNGAYHREVSPSKALHLSKVVSVPSQAIRSSIATQATVFNSACALVLSKESRSSDVVFGRIVSGRQGLPVNCQDIIGPCTNAVPVRAHIGTDGNHHQMLRDMQDQYLRSLPFETLGFEEIKRNCTDWPDSTTNFACCVTYHNFEYHPESEVEQQRVEMGVLSKHVELRKDEPLYDLAIAGEVEPDGMSLKVTIIARAHLFEEERVQYFLEEVCNTFQTLNFSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-02-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENM8</accession>
    <name>GUDIS_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inactive (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">STC5</name>
        <name evidence="7" type="ORF">FFUJ_11739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Angew. Chem. Int. Ed." volume="55" first="8748" last="8751">
            <title>Mechanistic characterisation of two sesquiterpene cyclases from the plant pathogenic fungus Fusarium fujikuroi.</title>
            <authorList>
                <person name="Burkhardt I."/>
                <person name="Siemon T."/>
                <person name="Henrot M."/>
                <person name="Studt L."/>
                <person name="Roesler S."/>
                <person name="Tudzynski B."/>
                <person name="Christmann M."/>
                <person name="Dickschat J.S."/>
            </authorList>
            <dbReference type="PubMed" id="27294564"/>
            <dbReference type="DOI" id="10.1002/anie.201603782"/>
        </citation>
        <scope>MUTAGENESIS OF LYS-288</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The Asp-Asp-Xaa-Xaa-Asp (DDXXD) motif is important for the catalytic activity, presumably through binding to Mg(2+).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Although similar to (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase, lacks the metal binding site Asn at position 288 and does not show (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase activity. Converting Lys-288 to a asparagine restores activity.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENM8"/>
    <dbReference type="SMR" id="S0ENM8"/>
    <dbReference type="STRING" id="1279085.S0ENM8"/>
    <dbReference type="EnsemblFungi" id="CCT75704">
        <property type="protein sequence ID" value="CCT75704"/>
        <property type="gene ID" value="FFUJ_11739"/>
    </dbReference>
    <dbReference type="KEGG" id="ag:CCT75704"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11739"/>
    <dbReference type="HOGENOM" id="CLU_042538_0_1_1"/>
    <dbReference type="BRENDA" id="4.2.3.165">
        <property type="organism ID" value="2425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000443321" description="Inactive (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DDXXD motif" evidence="6">
        <location>
            <begin position="134"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="375"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="mutagenesis site" description="Restores (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase activity." evidence="3">
        <original>K</original>
        <variation>N</variation>
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B5HDJ6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="27294564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="27294564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="27294564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="CCT75704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="401" mass="45986" checksum="95AA657CB9CA63E1" modified="2013-09-18" version="1">MVKFDSGSESEMTNGDELHINSKHEVKSRMANGNGVHNVPDHDQFQDRAEMEVLILPDLFSSLMSVPARENPHYASVKADADEWISFVINADAKWASRNKRVDFTYLASIWAPDCSAFALRTSADWNSWAFLFDDQFDEGHLSNDLEGAINEIARTREIMEGTAPRYTADSEHPIRYVFQTLCDRVKQNPEGFYAGKPSSERFYRRWMWAHELYWEGLVAQVRTNVEGRSFTRGPEEYLAMRRGSLGAYPALVNNEWAYGIDLPEEVADHPLVFEIMIIMSDQILLVKDILSYEKDLRLGVDHNMVRLLKAKGLSTQQAINEVGVMINNCYRRYYRALSELPCFGEEADRALLGYLEVEKNHALGSLLWSYNTGRYFKSKEDGARVRKTRELLIPKKMAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENR7</accession>
    <name>S0ENR7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to sulfite oxidase and related enzymes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11849</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437855.1">
        <property type="nucleotide sequence ID" value="XM_023570794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENR7"/>
    <dbReference type="STRING" id="1279085.S0ENR7"/>
    <dbReference type="GeneID" id="35405310"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11849"/>
    <dbReference type="HOGENOM" id="CLU_003827_5_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="6">
        <location>
            <begin position="61"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="7">
        <location>
            <begin position="247"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="353" mass="39077" checksum="4E231EE4B332CE19" modified="2013-09-18" version="1">MESVIAKPMSHAISPVPSTGAERQACTSIDPEGFFLRPPPTPHHLSSFITPDDQLFQTIHMGAAVIDNEKWLLVVDGLVRKPFALSLAQLKAFPQASVTSFHECYGSPLKPPTSNPWRIGNMVWTGVRLSTILALAEPLPEACFVWSEGLDHGKFFEYEADRYQKDLPVAKAQRAEVLLALKINGDPLSKERGGPVRLVVPGWFGTNSTKWLCRLSLQETRAPGPFAAVLYNEKDPTDPESVRMRPVWEVEVNSMITKPVDSAALSAGSVWVEGWAWSHDGVALVEISRDEGQSWIRGKVDDKEDQAWQKFTAAVDLEPGVWRLMARATSESGMQQPLAGRRNHVHSIPVNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP29</accession>
    <name>S0EP29_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_11651</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438140.1">
        <property type="nucleotide sequence ID" value="XM_023570573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP29"/>
    <dbReference type="STRING" id="1279085.S0EP29"/>
    <dbReference type="GeneID" id="35405112"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11651"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="4"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT76094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="316" mass="35769" checksum="3B03E00F85438927" modified="2013-09-18" version="1">MDNYQRIEKVGEGTYGVVYKARDLSHNGRIVALKKIRLETEDEGVPSTAIREISVLRELNHPNVVSLLNIVHADGHKLYLVMEFLDLDLKKYMDSLPVTDGGRGKPLPTGTATTVRNLGMDEKVVQKFMLDLVQGIKYCHSRRILHRDLKPQNLLIDKDGNLKLADFGLARAFGVPLRSYTHEVVTLWYRAPEVLLGGRQYSTGVDMWSVGTIFAEMCSKKPLFPGDSEIDEIFKIFRTLGTPDEDAWPGVTTYPDFKPSFPKWQRDFSTPLCPNLDEAGLELLDYMLICDPVTRISAKAALNHPYFDEILRIADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHW9</accession>
    <name>S0DHW9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to GTPase Rho</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423731.1">
        <property type="nucleotide sequence ID" value="XM_023573873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHW9"/>
    <dbReference type="STRING" id="1279085.S0DHW9"/>
    <dbReference type="GeneID" id="35395357"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01874"/>
    <dbReference type="HOGENOM" id="CLU_894427_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="311" mass="35844" checksum="B4A92489BD1A1C21" modified="2013-09-18" version="1">MSLLNMMPEERIDSWRQRVPSRMDREDPFEGDHFDERPSTRLTFHDVSPPEARPSTRLGFFRAATPMFGRSSTPSSTRPASSMMQRRVEGKRRSFLSLLTRKRKRKEPEEIPRDPVRLNFLFVGSKAAGQTSLLFRSRYGYFPDSNAFSRPLFETYVNERIYHNQPLTYIEWDAVFLCFDISDKISMYTIIQWWHHASSQGFTKSASFAPLLYLVGLKKDLRDQCFLEDHQTGSAFSSSGLLAYPTCCICSSEATWQATRIGAHKYIECSAATGEGMKEVIDDSGREAMRRLVGGQVPEEEVIPKKKRRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHX7</accession>
    <name>S0DHX7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423692.1">
        <property type="nucleotide sequence ID" value="XM_023573562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHX7"/>
    <dbReference type="GeneID" id="35395383"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01900"/>
    <dbReference type="HOGENOM" id="CLU_1107381_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058645">
        <property type="entry name" value="NTF2-like_dom_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26534">
        <property type="entry name" value="NTF2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484223" description="NTF2-like domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2-like" evidence="3">
        <location>
            <begin position="82"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="264" mass="29048" checksum="0D7A815763ABF30C" modified="2013-09-18" version="1">MKAYLALSILACAISTSAKNIHRRADAILPAAGIPVKGGYNAYGGNYDHPETNKYQPVGQKQASSSSTTTTGGKKATTQTTKCISKSKLESIVNKYVSTFSGITDGGALAKTIFEEDWTSSSSKINKYAKVNTSSPFHCTYQANKLQNDDFPPIYKNRKELIEGNTEKTNDPSAFIKGPIAYGCNSFTFYWKGDFEVPKGTRRGRGNGIDMVFLNPETGKVKKAYSEYNTLNQVYNWGAHITWSKDEVCCDCPVVFDPKCKCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI50</accession>
    <name>S0DI50_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to positive cofactor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423807.1">
        <property type="nucleotide sequence ID" value="XM_023574796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI50"/>
    <dbReference type="STRING" id="1279085.S0DI50"/>
    <dbReference type="GeneID" id="35395274"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01790"/>
    <dbReference type="HOGENOM" id="CLU_004682_0_0_1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="126"/>
            <end position="356"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="91"/>
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    </feature>
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        <location>
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            <end position="229"/>
        </location>
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            <begin position="290"/>
            <end position="310"/>
        </location>
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            <begin position="649"/>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT61726.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
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    <sequence length="983" mass="107809" checksum="2C09B780CE355309" modified="2013-09-18" version="1">MAPVGPIVHQNVANKVKRPVPPGIQTNGAITSSKSSPSPSMSAKKPPPSAKQPPHSASDRAITASTVRPVNRARRETASQLQGRHSRNSAGLRSASLAADHSGHDAEPRPYIVTDSYILNKFAGRPPSLVCHLHTTHFRFDNQDGVRTIPHDLLSYFTDAGVPFYDGCLIVQVHDHKSLAQAKNVAKPTKGKGSMMPSSIHNYNQCLTPSPNVPFPKENLSNGDGSSKGNDVAEKENAPVMPASEEQKDRATKPRVFTMVLHPTAESLQMDLLIKASTPRGLGDGLGQPPSTPMSLIPPTPTAGTMPPPAKRQKREKTELDSSNIHAAEGQILLATNAPLVLEPTKNLEETIILMEAMSHPKHAEAPPQPKTRKRTVAEMAADEAAAAETERFMLVADERLAPNANGAQNGGTADGDASGGASAFEPRFERFKVLAEISREHAEKKEQEKLKQLENDRKLQQAKQQQQQDAVALAQKQNAEQERLRREAAAREAQMRQAEAQRQAQARAQAANQNSQNNQNAQRVNGNQPQHGHPQNNVVTNGVNNAAVGTPQMANNMPPQAQPRFQAQITQPPASSPVAGQGTPQHMSSPMVASVPMQQTNSGMANSPPRPSSVVQNAAAMSVPMAHNMSSRGSQQSHPSGTPRIPHSTPNMTQGTPINRPAMVATPRMSQASPPPAMMAQNSQPGQGMMMNGQAMNQMNPQYAAQLAQQRAVQQQQQMAMQNGLNSGNMSHMSPQQQQQMMQAMQRQLMATQQAQQQGNMISPQQQQQLAAQYAQQMQNMSGNQIRQFTPQMQAQFQQMMRMNQVNGQMGNSPMQRQVSGQMMPNGMNLQAFQAMQQQRQQQAQQQGNMMSPQQQQQVQQQQQAQQQMGQMGQQNPIQAQMQQQARLLFSRMMPAVAQKYGGQEHIPPDVIEKMKTQSMGQAQSLMQASMAQRRQQQQMMQQQQQQQQQQQMHQQQMQQQQMQQMQQMQGMNGMMGGPQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK30</accession>
    <name>S0DK30_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable ribosomal protein S19, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_01845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
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        <property type="protein sequence ID" value="CCT61677.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT61677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="91" mass="10405" checksum="2C021E71B9768DFE" modified="2013-09-18" version="1">MHATRVLLKRSVWKGPHLVPLPIVWPKSSSDKVPPVRTQARSATILPNFVGLKFEVHNGKDYHEVTITEDMVGHKLGEFSPTRKPNIWDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK55</accession>
    <name>S0DK55_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425035.1">
        <property type="nucleotide sequence ID" value="XM_023573290.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1279085.S0DK55"/>
    <dbReference type="GeneID" id="35393926"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00441"/>
    <dbReference type="HOGENOM" id="CLU_021323_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14014">
        <property type="entry name" value="STKc_PknB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="318"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="624" mass="69800" checksum="8021A96CCB091AF0" modified="2013-09-18" version="1">MAEPRLGLSEVVSEERTEPFSQSEIDARFKGIGVEEPVPTTSSSLVSLDELHVEDHHHRQGIRILFRPLANFPKSRSVSPGSESLQWLALRAEVASPEQPEHKVLAVTQTSKDIKFTVRIPGETQDDYPRPPLWCELYYDPASDKVIFLNRSDLPISLSGVSPTPPSSPYSPSHVVNPGSAKALRPGTWRITLRDMEVLDFRVLEKRPVILYQPQQQTIVEDVPSESSTPTVNSSGKRALSPEYDEKRVKRRVSDPNTPGDDGVVMFLRPSADPLIFSLPNGRESKELSSVNGHPLLDAEKGETAAISGVCEVDEYELTKREPIASTSLSAVYTATHSHVPNNIVTVKVLKTRVANPNDKALVHERTVIRQADMWLRECRGQEDLQHKSIVRYYGGDARFLSLYMEHIDAKDLTSMPRWRNNTNDEFIGDRNDAARILGDIAGALNYIHGRKLVHNDIKPANILYSPERGAVLCDFGLSTPATATNSPTVGGTPYYVPPEFIGRKQRGPASDVWALGVTMLYVLRKITYPDSRAHRRHPRPLYWLIAGVNSPNMPHKQYGNGQPAMKQMRDWLAEIFDARKSLNPKDRLERIVMEMLYPNPNQRITMAKVVQELAVEQAATPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK56</accession>
    <name>S0DK56_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF614 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424822.1">
        <property type="nucleotide sequence ID" value="XM_023572419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK56"/>
    <dbReference type="STRING" id="1279085.S0DK56"/>
    <dbReference type="GeneID" id="35394160"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00675"/>
    <dbReference type="HOGENOM" id="CLU_083147_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22740" checksum="FD3F8175BB122F91" modified="2013-09-18" version="1">MAQQYSQGPNVQNQEWQNNLCNCSPCDSCLLGTFCPCILLGKTADRMRDPTMQTADTCNSDALIFCAINCVTGCGWIYSMMKRGEIRERFGIKGSGMNDCCVSYWCLCCALIQQDNEVKSRLSQGPITQGYQAQKEGMHMPTSPPAQQQQQQQQYHDQKPNPQQQAPQPDYQLPQHDYQSPQPQGSYPPPQQTYNPQQPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL20</accession>
    <name>S0DL20_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425182.1">
        <property type="nucleotide sequence ID" value="XM_023573466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL20"/>
    <dbReference type="STRING" id="1279085.S0DL20"/>
    <dbReference type="GeneID" id="35393768"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00283"/>
    <dbReference type="HOGENOM" id="CLU_044876_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="303" mass="33128" checksum="E7738689113BD262" modified="2013-09-18" version="1">MGKIAVAGGSSGLGRTMVDALDAAKTHEYIVLSRKATGPETRAVDYSDIDALTSLLQSEQVDTVISMLPIDNDDSGQAQMNLIEAAEKSTCTKRFLPSEFGMVYTRENIAHVPSYQWKLKAVDALEKTNLEFSLVSIGLFLDYWAAPRIPTHIRAANIIIDPENNAAVIPGDGNTPVVITHSTDAAKYTVALLDISNWKRRYAIVANRMTLNEAVKLAEEVKGVKFDVQYFSVEQMKSGENDLTPSMKKALPEEMHGGMKAMLALSGIGMATGSNDIRGIDDLVVKLPDIKPVTVRDVWDAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM34</accession>
    <name>S0DM34_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425581.1">
        <property type="nucleotide sequence ID" value="XM_023572029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM34"/>
    <dbReference type="GeneID" id="35394195"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00710"/>
    <dbReference type="HOGENOM" id="CLU_2061670_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="119" mass="13317" checksum="8D443F3436DBBF14" modified="2013-09-18" version="1">MYYPSKALPLAEGKAGWLVDEWTMDQGTGGPLWLAPALRTDRNHQFSRGIEATTSASIFARHFALNLTALHRYKTTIRENFQPPVHDKEPVKPQTVDQGRWIVAPKLVGHIEKRTGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM57</accession>
    <name>S0DM57_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424543.1">
        <property type="nucleotide sequence ID" value="XM_023568952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM57"/>
    <dbReference type="STRING" id="1279085.S0DM57"/>
    <dbReference type="GeneID" id="35394472"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00987"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_37_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004711">
        <property type="term" value="F:ribosomal protein S6 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000222">
        <property type="entry name" value="Serine/threonine-protein kinase psk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="172"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="434"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT62462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="515" mass="57711" checksum="A4C3AA84D7EAB83C" modified="2013-09-18" version="1">MISQAPAAVTTVRGFQTTPATSGDEDSDHGHSEAPTPRRKTPGRNLMVNDVVSANCSPTFRAHPSPAMSGIAKLRMQMEPLSLDGGSPCHSMSRAGSQQGLALEFRKQMISRTHSREDVRSEAGSEISDSSISYEVNLEHDFASESVRERSGYLETLEGGLVPNRKMTSEDFEQLRCLGKGTYGTVLLVKQRATGRLYAQKQFKKASLVVHKKLVEQTKTERQILESVNRHPFVVKLFYAFQDQEQLYLILEYGQGGELFTHLNTEKMFSEDVAAFYMAEMLLAISHLHNDLGVVYRDLKPENCLLDAEGHLLLTDFGLSKVSVDQNESCNSMLGTVEYMAPEVVLGKKYGKAVDWWSFGALGYDLMTGNPPFRGQNHAKIQDNIVKQKLVLPYFLSPDAKDLLTRLLRKDPSKRLGAAMPKDLTTMKKHRFFRKIDWKKLAERELEPPIQPMITDPELAENFAPEFTELSISPVLPNKEAWPRSLPKDELFGGFSFVASSSLLNEDRFAAFAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMD0</accession>
    <name>S0DMD0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423799.1">
        <property type="nucleotide sequence ID" value="XM_023574706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMD0"/>
    <dbReference type="STRING" id="1279085.S0DMD0"/>
    <dbReference type="GeneID" id="35395282"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01798"/>
    <dbReference type="HOGENOM" id="CLU_868916_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT61718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="376" mass="42911" checksum="5061B2FC791A30E6" modified="2013-09-18" version="1">MHTHPNQIRSACERCRRQKLRCSRSLSSPSCARCTRLGLTCQAGLQRRVGRPPKKDMVLHRPAEDMQFVQVLLDDTAWNLDPFCGYTPESLPFPMDAWPSVSELDPPEIEQKIIVPSMQVFEKLSKLNVDIHRGWEFVSQLENDFRLSAFVCEDRERQNGYQNIQVVLKAAQEYLVVLKTLHRQLGIRTVYCQGRKPHTNRMMLSLEANTESPEPIASSSGEATPTSGSTTPELPPIFDSPTMFLIISCYVQLIKHLDVVLRIIFNSISDPHQDLIDAAPMSFAEVPLIEPSTQFVLFSEMFRHIMSQMNLLMGLPSAWSSKSAWTGLLTNQRYRDMLNTELGDVEDGWTTRPGKLMEINRITKDMLDEFTMMGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNG8</accession>
    <name>S0DNG8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426061.1">
        <property type="nucleotide sequence ID" value="XM_023571820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNG8"/>
    <dbReference type="STRING" id="1279085.S0DNG8"/>
    <dbReference type="GeneID" id="35398326"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04845"/>
    <dbReference type="HOGENOM" id="CLU_104295_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="182" mass="19434" checksum="0E7701AD2950E8F0" modified="2013-09-18" version="1">MVGSILRQFFSPATRRPITTALSTPPSRLIRPSLRTFTTSAPHAFAPTTARPATLNQVLRGIRKGKRARHAVSPALSNTNCPALKGVCLRVGVVRPKKPNSGERKTARVKLSTGAVVTAYIPGEGHNIQQHSVVLVRGGRAQDCPGVRYHLVRGALDLGGVASRTTSRSKYGTKKPKKATVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNH1</accession>
    <name>S0DNH1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable mannosyltransferase involved in N-linked and O-linked glycosylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_04844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426062.1">
        <property type="nucleotide sequence ID" value="XM_023571821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNH1"/>
    <dbReference type="STRING" id="1279085.S0DNH1"/>
    <dbReference type="GeneID" id="35398325"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04844"/>
    <dbReference type="HOGENOM" id="CLU_024327_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT63981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="465" mass="53594" checksum="E32C0AC8D29B40B1" modified="2013-09-18" version="1">MAAGHTRYVRYIALALFTLTMFYFFSNSKIDTIPVPGSVGNFPGGPGSPSNQQQAPGTIPKSPDAGNNVNFPGQQAPVAEEGDTALTKDDAPAQKPAGDAPAVPAPQTPKEGPASGELAEAPLAMSPNDPGWSNLQGTAPGPRMNATFVTLARNQDVWEIAESIRQVEDRFNRRYNYDWVFLNDKPFDEQFKKVTTSLCSGKTHYGLIPEEHWSFPEWIDQEKARKVREDMHERKIIYGDSISYRHMCRFESGFFFRQELMMNYEYYWRVEPSVKLFCDIHYDPFRVMHENNKKYSFVLSLYEYIDTIPTLWASTKKFMQNHPEHISSDNSMRFLSDDGGENYNKCHFWSNFEVGSLSWLRSKPYLDFFESLDKDGGFFYERWGDAPVHSIAAGLLLKKEQIHFFEDIAYYHVPFTHCPTDEQRRLDLRCHCNPDNNFDWKGYSCTSRFFELNGMEKPKGYEKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP36</accession>
    <name>S0DP36_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_04449</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426420.1">
        <property type="nucleotide sequence ID" value="XM_023572265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP36"/>
    <dbReference type="STRING" id="1279085.S0DP36"/>
    <dbReference type="GeneID" id="35397930"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04449"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="52"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT64339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="381" mass="41006" checksum="51C8AC68F261D072" modified="2013-09-18" version="1">MLAIRALRTPASRQALRAATPRAAIFYNRCYSTSGERVAKYNGTKDANGNFLVSLIEGDGIGPEISQSVKDIFAAAKTPIAWEPVDVTPIIKDGKTAIPDAAIENIQKNKIALKGPLATPVGKGHVSLNLTLRRTFNLFANLRPCRSVAGYETPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQHAESIGRKKVRVVHKATIMKLSDGLFLKVAQEVAKDFPGIEFDAELLDNSCLKMVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKNLANPTALLLSSIMMLRHMGLTDHASRIETAIFDTLAEGKALTGDLGGKAKTNEYAAAIISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQH2</accession>
    <name>S0DQH2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425733.1">
        <property type="nucleotide sequence ID" value="XM_023571426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQH2"/>
    <dbReference type="STRING" id="1279085.S0DQH2"/>
    <dbReference type="GeneID" id="35398678"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05197"/>
    <dbReference type="HOGENOM" id="CLU_1065777_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="261" mass="30435" checksum="ABE1FA5D384C9FCC" modified="2013-09-18" version="1">MASGCNQNSSATPRHLQIFNPPLEPCGDFHLFARLPDDIRWLVWQHSLGHERRIDISLNRLDYTNPTHRMRELANSEDRYPVYQMNHVVPIRSAVQSFDRLPYDPRLLGEDLKQVFLGDIDPQAPFNRWLKLLSTSGVQHKHKVIYQFGICRGYKTGYSHKEPIISNRQSAVEWVQHDTDEFRRWFETFHRSPELRGQIDHEITRVFEESPQPVVGFWSFPMESVFVPEDPKIHGTDTSRAGLTTVGMSQHMPELCLANIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQM0</accession>
    <name>S0DQM0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Catabolic 3-dehydroquinase</fullName>
            <shortName evidence="3">cDHQase</shortName>
            <ecNumber evidence="3">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">qutE</name>
        <name evidence="7" type="ORF">FFUJ_05139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQM0"/>
    <dbReference type="STRING" id="1279085.S0DQM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05139"/>
    <dbReference type="HOGENOM" id="CLU_090968_1_0_1"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003804">
        <property type="entry name" value="PRK05395.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003806">
        <property type="entry name" value="PRK05395.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF3">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3 4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3 6">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="150" mass="16210" checksum="E586A895A9383DD2" modified="2013-09-18" version="1">MSRRLLLINGPNLNLLGTREPHIYGSTTLADVESSASAQAESLSSSLESFQANSEGAIVDRIHEARGKVDAIIINAGAYTHTSVAIRDALVGVDIPFVEVHITNVHAREAFRHHSYLCDKAEAVICGLGVFGYSAAIEYAVKHLKLRTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR10</accession>
    <name>S0DR10_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426971.1">
        <property type="nucleotide sequence ID" value="XM_023572933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR10"/>
    <dbReference type="STRING" id="1279085.S0DR10"/>
    <dbReference type="GeneID" id="35397330"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03849"/>
    <dbReference type="HOGENOM" id="CLU_014303_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="896" mass="98284" checksum="D853BA57048028CF" modified="2013-09-18" version="1">MLLAAQPPQGRTRSNSLQQMLDLEKKLNFQRTHQGSVPPSPACTESSGSVPPSPGHPPRRFELVPKDKKGPTPVRNYSAVPPPLFSAPERSESPNMIARKPVGKNLSQSSSSEQLKDDKPAHKTVAFMFPPDVEEQRSVCQSPTWEAYERQKKEKKEEKRQELQRKEEEKRKAKEKEQELAMNQALEEAWKNAPKPRGRKLSKPKPPPPSLGTQGRSTTEPPQTTQKRRSRSSSLLGFSIGRNNDDPEEPRRSRSSSLTSIFRKSFEIKRASFDETSPTGFLGGKKLEKKKDDFHQKVLEDQAKGDSRVHPAMRKSFLGHGSFTPLKVNPQQKEEDAKRRAYPPISINTSGARGQSKPAKSPSRRGSVNIYLWSARARRGSVSDDCAVADTDDEGDQNTAHTPDSEILYNKAQGLNRRGGLYIKKEEGSIKDGEQGVTPRSSNQSMKQAAKPKDTEKPPQQDTITVSRPPITNPTQPQARRSSTASGLSIPPPPPRRSSKRGSLTLLTRLNNSQPASDEAKSAPVESSKSKERLFRHNPPSIRYEQTSPGVRPKPITADSEPAVPTKWKLKDAAKSAFSRGHSAQNSVSSTMSASSKMSSASSVGPPVPPKSDLSVSKGLAGANDAPIRTQHVHAPVKHLAPGTTRSPIGRRPTTSSSESSYSDGIQTVSPMSTPHTSPPQSEMGHSPSIATIKPSMHATAGPVSPYWSYTNSPQMAPIDRFDTNPSDPEIDPIQEAANSVMEAFSNANLRNSTPRRTPVSSDETSFASAPTYPPLKHKPRSKGQLRSVKSGHRSTVSDPEATIKTLRRQSNLELQHHGEPSAKMFVECCACMRYHDMPSRLYEAMSNPDGVLSAGSTDFAGSVTMTVKCPWCKHEMSTKCCAGFAAMVYIKERFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRC6</accession>
    <name>S0DRC6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to general amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427195.1">
        <property type="nucleotide sequence ID" value="XM_023572699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRC6"/>
    <dbReference type="STRING" id="1279085.S0DRC6"/>
    <dbReference type="GeneID" id="35397541"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04060"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="68"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT65114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="535" mass="59750" checksum="3FEA98050C82AA37" modified="2013-09-18" version="1">METKIWQQVIAEKRRQRTRVISAFVTENLPDKEDRRDAYKAITEVDDITILADKISTGKLRSEDVTLAAIEAHNKTNCLTEILFDDALEQAQELDAYYAKEKKTKGPLHGIPISLKDQFNVKCYDTTLGYTSKAFKPAHDDAVLVKILKKLGAVIICKTNLPQSIMWAETDNPLWGLTENPIIPGYTPGGSSGGESALIYSHGSLGGFGSDLGGSIRMPASMMGLYGFKPSSSRLPYGGVPVSTDGQEHVPSSIGPLARSLSTIYHLTKGITLQEPWKQDCRCVPIPWRQSEYDMTVNSKLTIGVLYDDGVVKPHPSVVRVLAQAAAALAADGHELVMWKPDLHAECIEVMDAYFTVDGGEDIRRDVEAGGEPFIPSVERLVNRGKPISVYEYWQLNKRKRELQQAYLEKWNNTLSKKGKIVDAIIMPALPHAAVPHNTVKWVGYTKVWNLLDYTALVIPGGKVEARDLDALWDHEPRNELDEWNTRLWEDNMQEMVKHHLPVDIQIVGRVLEEEKVLAVGKVLDDLLRTHLLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS12</accession>
    <name>S0DS12_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to 3-oxoacyl-(Acyl carrier protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_02165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427317.1">
        <property type="nucleotide sequence ID" value="XM_023573864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS12"/>
    <dbReference type="STRING" id="1279085.S0DS12"/>
    <dbReference type="GeneID" id="35395647"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02165"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="295" mass="31590" checksum="2C462522FBFDFFB8" modified="2013-09-18" version="1">MSSRIQNITNHLAPDGDQTTRLMKGDPSRIDGQVVLITGGAQGIGKAAANLLASKGGRIIIADVDKSKASATVQELQSGGYEAAYIIGDALEDGFAEKTVAFALETFGKVHCLINGAGFCYDAAIHKMDDDKFDVIMKIHNYVPFRMVRALSSHWMARENREMPKTIINISSTSGLHGQMGQINYSTAKMGIVGQTKTIASEWARYGVRCNAVAYGWIDTRITRPPTSDETVVVGGKTIQTGIPIAAKKFRDVSEIPLSRPGTVEDAAGVILFLASPLSAYVTGSCIECAGGRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSQ2</accession>
    <name>S0DSQ2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to mouse KIN17 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_02534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427660.1">
        <property type="nucleotide sequence ID" value="XM_023574277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSQ2"/>
    <dbReference type="STRING" id="1279085.S0DSQ2"/>
    <dbReference type="GeneID" id="35396016"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02534"/>
    <dbReference type="HOGENOM" id="CLU_030065_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT65579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="338" mass="38167" checksum="122C5FDBF5363AE6" modified="2013-09-18" version="1">MPKAEVGSTKYVANRMKAKGLQRLRWYCQVCEKQCRDANGFRQHTMSESHVRQMLLVGEDPKKYIKSYTQQFQSDFLQLLRTGHGEKQVHINHFYQEYIRNKEHIHMNATSFASLTEFAKHLGREGLCRVEENDKGVHIAWIDRSPEALRRQDALRRKEAQDQGNEEIEQRMIREQIKRAQATAGIREEEKEEDNEARELKRQEGEKIKLSFGAKPAASETKSSESPAPDTTAPEAESSKTADTTADKGKGPEVAPAKPGGFGGLSMKLGGKPQTKNVFAQAKKNALASGSKKPAKIEQPKKMSEAERIMKEEMEKKRSRESAGFSFGMGSGKKQRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSX3</accession>
    <name>S0DSX3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable FCF1 involved in the pre-rRNA processing steps of 40S ribosomal subunit biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_02638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427755.1">
        <property type="nucleotide sequence ID" value="XM_023574393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSX3"/>
    <dbReference type="STRING" id="1279085.S0DSX3"/>
    <dbReference type="GeneID" id="35396120"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02638"/>
    <dbReference type="HOGENOM" id="CLU_081098_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000019">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="70"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT65674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="198" mass="22758" checksum="EEF2F3E1BDAD4AC7" modified="2013-09-18" version="1">MGVQKKTRKFAEVKRVIGRRDARLKENKLKAELAQREKEKKTINGELIREAPQMPSNMFFQHNTALVPPYNVLVDTNFLSHSVQRKLSLLDSMMDCLYAKCNPIITSCVMSELEKLGPKYRLALRVARDERWTRLECDHKGTYADDCLVDRVQKSRIYIVGTNDKALKQRLRKIPGVPIMSVARAKYVIERLPGAPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTI0</accession>
    <name>S0DTI0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">FFUJ_04948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTI0"/>
    <dbReference type="STRING" id="1279085.S0DTI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04948"/>
    <dbReference type="HOGENOM" id="CLU_079430_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="196" mass="21348" checksum="747F849D9DCC8870" modified="2013-09-18" version="1">MSAKQSMLLFRALRMSQPTLRQPISRVSVCRFYATSTEDAPPPLLSKLKGDLKTAMRAKDTPRLTVLRAIMSANLNASKTSTPIKTDVQLVALIRKIQKSSQDAAAEAKAANREDLVQKEEDQIKVLDEYLANSGVESLTEAQLKAMVQDAVEASKAAGTQAKSIMGDVMKRLSGALEGKDVDRKELAKMVKELTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU38</accession>
    <name>S0DU38_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to cytochrome-c oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_02962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428051.1">
        <property type="nucleotide sequence ID" value="XM_023574754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU38"/>
    <dbReference type="GeneID" id="35396444"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02962"/>
    <dbReference type="HOGENOM" id="CLU_156745_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT65970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="92" mass="10787" checksum="15A28C18E9283A25" modified="2013-09-18" version="1">MGGLNLEVFKFGTYVMFPIGIMFYFGTNLDNRFAVPGFWPKPEECNKIPKDRDEIKAEYDRIVARQKLRQAKKLEEERKRAAQQPENDQSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUF4</accession>
    <name>S0DUF4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA N(6)-methyladenine demethylase</fullName>
            <ecNumber evidence="2">1.14.11.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04621</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:49521"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="2"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426264.1">
        <property type="nucleotide sequence ID" value="XM_023572071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUF4"/>
    <dbReference type="STRING" id="1279085.S0DUF4"/>
    <dbReference type="GeneID" id="35398102"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04621"/>
    <dbReference type="HOGENOM" id="CLU_029471_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000014">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="11">
        <location>
            <begin position="216"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT64183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="346" mass="39877" checksum="E5CE92F72C1219EC" modified="2013-09-18" version="1">MASANLTEIDAHEQPSDEMRAEWKSYMRQDHKSLLSDPRIDDPRAPFEESGFCQVSSLSKEQVAKSFAHLNPEFALQVEKDVPVIHHPLIPGLLILPSLVPENVQQDLLDRLIHRDLSVQNHQTNLHLHYNLPYPQGKDDNERSFFSISPETPASFLPKDPSVHKPLSIKQVMQRKLHWVTLGGQYDWTNRVYPEELPPQFPDDISHMLQGLFPETIAQAAILNFYTPGDTMMMHRDVSEETDKGLISLSFGCDGLFMIAPNDFKQASQNETPSEKQYLLLRLRSGDAIYMTQDSRYAWHGVPKVLKDTCPSYLEDWPARGDEKFADWRGWMKNKRINLNVRQMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV28</accession>
    <name>S0DV28_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428407.1">
        <property type="nucleotide sequence ID" value="XM_023575183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV28"/>
    <dbReference type="STRING" id="1279085.S0DV28"/>
    <dbReference type="GeneID" id="35396828"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03346"/>
    <dbReference type="HOGENOM" id="CLU_019791_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028115">
        <property type="entry name" value="DUF4484"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14831">
        <property type="entry name" value="DUF4484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4484" evidence="2">
        <location>
            <begin position="424"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="602" mass="66509" checksum="FE1587F6D7E0EAE6" modified="2013-09-18" version="1">MASSRRGQPSLSVRMPSNQPLDRPPIDALFLIHFDVKAGYTILWKQNAPGIDLEGLVEYKSLPSGLHTVSEDLIYFVHDSAHAGLSAFVNMPCDEEEARNARMFAVGVLVPLSYGRLGRAWRHAEGLKEMAAKLAEDRKNTSILEEYWVANREKSGNGNRRLSGETPVSSPSLNSSPFPRKAHSRNRSASDGASLIPPGNKLSPYHPAWSLTSLLDKFGPLIFPIHRAALLRKRILISCHAPVHEVCDFVYNLSVLSNIPLSVTDILPASASTQRLRPLFSIGVHDIPFLMDDFEASKRPRNDEDAIDDESGSGWIACTTDSILAMKDTLWDMLVTLPPDYSSNATERVWPVVECPRGQPIKATQRDLRRFTTLKNGLARLAAASQIPSAVPESPEEERSARRFSTQSSHIVRDPRDDAVEKVVEPLTWAAFAYNGYMWWASAGEQLRQEQQEEAAHDASLLADFGPSMTMPRPGSRSGQLSDSLGFELAIIAYFHRLTTQILSVLADLADSQDEPYTDHDDDDEGLSQASGERAPLRPSDSDPEPDDADAIRVDSHAVESMGLDVWSDTDALFIRELSILYFGRPARIEGKGVEVCGVRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV36</accession>
    <name>S0DV36_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428510.1">
        <property type="nucleotide sequence ID" value="XM_023575308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV36"/>
    <dbReference type="GeneID" id="35396940"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03458"/>
    <dbReference type="HOGENOM" id="CLU_004495_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF28">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="520" mass="56336" checksum="51034906D1128EB0" modified="2013-09-18" version="1">MNNAEKGVSEKGSDHEQAKNYDHAVGDAGDAADLTALGYKPELKRNRSMFTLLFQSLAIAAIPYGFGAPLINSVYGGGQLTMFLGWIIVCILDECIAISLGELAARWPTSAGPYYWSFQIASPKYRTVLSFITGWTWLVGNWTITLSVNFGFASLLAGGISIFLPDYDWQPWKLVLIFYGLCVFTFFIVAFGNKFLPTVDTFCAAFTAITIFVVCVCLSTKADKGRHSASYTLGNFDPNLSGWGNFGFWIGALPSAYTFSAIGMITSMAEECGDVTVKLPRALALCVPVGGIAGLFFIIPICATLPPLEELLAAPLGQVLPMIFYQVMGSQAGGIALTALVLIITLFCSISITVAASRTTWAFARDEAIPLSRVWSKVSKRHETPIMALLLTTIIEMLLGLIYLGSSSAFNAFIAVGVIGLASSYGIPILLSLLTNRAGVNTAPWTFGKQIGWVINIFALAWICFEMVLFCMPVAIPVNAVTMNYAVVVFFGFMAMSAVWYVVHARHVYKGPPESDGLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVH3</accession>
    <name>S0DVH3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428556.1">
        <property type="nucleotide sequence ID" value="XM_023575365.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DVH3"/>
    <dbReference type="GeneID" id="35396991"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03509"/>
    <dbReference type="HOGENOM" id="CLU_002322_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.790">
        <property type="entry name" value="RNA-dependent RNA polymerase, slab domain, helical subdomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="511"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1388" mass="157586" checksum="2954DB90C6BBE491" modified="2013-09-18" version="1">MAGQLSLKKAEQAKDELDRTVRSLSTDFQLQLHIPDLTLSPSKRRQQHRNGDQERSEHIYLCAYRLKFQDPNRLAICLTRFREQADEHLKNWIRKPRADPDTTPSKSFGPPRSHARLASEERAELQDFLLQLLKDDNIASRQRSKHSKRKSDEFPDPSSKRSRNSFEGSPACESIDSIPVRSRAVASSSRLLTGRPARGAGTSSFTNGIATASFASTQPSSFGTRSFNSSKVSLAPTVFTNDYAPSTQATTVTNTSFKRSQLPFQATQPSLTSNATSSKDIQIPFSQSIRKFAYQPPSEENRNDIDPPKPPSFRRYEDRTPPEPVIDLTDDDEPEEEPRLPILSIPQPIKSQVDFKRAGMIRSSSPATAYSSLPEMNEFDTMLFDAPISDPELPECLLTDRLRNIWPKFPIPGLNQAPLIILWELTRAALHCRVDLSTWDLEYQPNDSWHDQTKFRGQLFRHRLFVGQGLPPACDRAVWDAAFGSFASHDKAVVLAGEFVCNTEDTGQLYRLKLQPPRLELGHRLARRFGADRFLEVIMPSPTSRDAPDLIRQDPQGADKVIKWLTESFHYFVGRSWAAFYTREAKKSIKDPRPPHKSLTIMQERVYFFATDGINFRIPMSQFPPLEEATSPGHRTKMRRCDLLNWAINIEQNSSQPVPKLFSRLALSLSKTVPTIVIEPHQFRHLDTMLGFHKYMTKKEKKEQKDMGDGIGRMSRNLARRIATHMGLLETPCAFQARIGSAKGMWIVDVEDDGLDNDDWIETYPSQRKWNCDFEDVHHRTFEVREWSRELRSAALNTQFIPVLEAQAHVPQDMRNVIARHLANGLQEEIGGQLAAMTHPTNLRGFTHRGFDRATLGNVPFLGALPEREEDIISYMLDAGFDATKCRFLRDMVWKAQKRQADQLKEKMNIKIPRSTYAFMTVDFTGTLEEGEVQLAFSSKFQADGESDTLLDGIDILVARAPAHFVSDIQKVKAVFRPNLKRLKDVIVFSSKGKSPLADLLSGGDYDGDLAWICWDPDIVNNFNNAPKPVEPDLVGQGYLRKCNPSFESILNAAADVDSACAYFLCTAISFNMQPGYLGIATKFKEKLCYLERGVNSERAVALSTLVALLVDQAKQGLLFTREDYDRLKRDMNMKGKDPEYENDRSSRRNYVNRDGSIHILDELKFVVAEDTIADVLKRFYDALFGKDVPVQAWDKDLARLWDDFESQKNESKIIGRLMTALHAQVSGTIKEWKRAMAGGRIDSSHNEFPAKVRELYQKWSSYQPPQELLMSKQVKPLLDKWNGDPSLSRWELLKASTMFKLSYNEAYLMLWHLSGKQLAWMKATMSCSTSDASAIAVTAEMWSILRPDNKRIAALNARRQIGHDNESLAALEEVMEYDETGTQIDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVU3</accession>
    <name>S0DVU3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to transcription activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428760.1">
        <property type="nucleotide sequence ID" value="XM_023573834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVU3"/>
    <dbReference type="STRING" id="1279085.S0DVU3"/>
    <dbReference type="GeneID" id="35395620"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02137"/>
    <dbReference type="HOGENOM" id="CLU_006123_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="317"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="713" mass="79163" checksum="889FD9DB0EDD2E47" modified="2013-09-18" version="1">MVSSREYQSTCHYTRSIGKRGRKPKSANRVQQPQQDREPDSSEADCDVEQNTPHPRPEQNGTFDVQGSPGLPTNPHDTVSSHYSSSHSSHHDAVSLDIPAESIPAPTFDQLYHVTDIQPSYPLPDFDLAVHHGADSVHESPARERASTVTQSLPSPGCRYKCLEPIIPLLHGIIDARLVCELFELYFVEPGGSLFKSSSPYVLAHVMRKESLLRTDNPRTCTPALLVTMLWKAIVCEGLRKLMMGLIQGRDRDVWNRTTSGPLVRDLEYATTGDQNRQEYHVGSTFIVSPPVPLVDDVLMFILITIVSSGGDFKTDCLRWWNKALRLSHNMGLNREDSPENSFTQSETSLCTSQTTSCGCRPCEASRTGLSIAEVREERRRAFWLIFCLDRHLALSYNAPLRILDDECQLHVPLSDEAWAALSTGQNPVDAAFGNSSHSADFGTPTRITGTGFFEYFLPLMTILGDVIQLHRQKSHPRFGSIRRPQVNGHEEEDDPATAMIEQVMAQCAQSITDLAGAYQVDALDASTIPASQVRTPQCAISPQQSHGDHSRTSNTASHASSHRQHAQAQLVTAYSTFILHVLHVLLHGKWDAVSMLDNKDGWIPSVGFMKCASHAIAASDAMSRILMCDPELSFMPYLFGIYLLHGSFILLLFADRMPQIGLNESVEKACEIIIRAHEVCVVTLSTEFQVYFPMPSIEAAIFLNPSDTNCHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVV8</accession>
    <name>S0DVV8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02597</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428780.1">
        <property type="nucleotide sequence ID" value="XM_023574347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVV8"/>
    <dbReference type="STRING" id="1279085.S0DVV8"/>
    <dbReference type="GeneID" id="35396079"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02597"/>
    <dbReference type="HOGENOM" id="CLU_024877_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110103">
        <property type="term" value="C:RNA polymerase II termination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140432">
        <property type="term" value="F:5'-hydroxyl dinucleotide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990174">
        <property type="term" value="F:phosphodiesterase decapping endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110152">
        <property type="term" value="F:RNA NAD+-cap (NAD+-forming) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904595">
        <property type="term" value="P:positive regulation of termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030846">
        <property type="term" value="P:termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="374" mass="42751" checksum="3B5C31B3CE9FE710" modified="2013-09-18" version="1">MSARFSVQPIGRFAGASQPVKRPKEFACFSYDDNHEFHLDDSSLKYYYTPQLGADLSKGFDTFQKLDDTGDDHLDSLLKTIAAHEQETGKKIDANVVTWRGMMTKIMAAPFDQMDGFEMNATLYQDCIFIEENNAYKIASRSNEGNNKRRRGPPLEVMQFWGYKFETLSTLPAPWAEMSRDFIENRENEVVNNKAQYCSVVRTGIGKSVLCLGGEVDAIWDSKPEEKGSPINWVELKTSAEIRNPGGMENFKRKLMKYWIQSFLLGVPRIVVGFRTQDGILVEAREMETHRIPDMVNADPNPKWNADMCVNFAATFLEWLTENINDEGVWRIRREPQSPTIELFKVEETGHGDILSDEFKNWRIKLDLGPSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DW31</accession>
    <name>S0DW31_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_02173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428761.1">
        <property type="nucleotide sequence ID" value="XM_023573872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DW31"/>
    <dbReference type="STRING" id="1279085.S0DW31"/>
    <dbReference type="GeneID" id="35395655"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02173"/>
    <dbReference type="HOGENOM" id="CLU_400108_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="252"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT66680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="688" mass="76464" checksum="0FA533292105D87E" modified="2013-09-18" version="1">MATSIQPPRQRRFIKIRSFRACVVSYVVSHSSWEHVTAQRNSSSDCLNTLTSSTQEYLESSQQDGAVSPPTKFNVLPVTSAGHVIYMGESAGFNLLLSGSQGPVVHFPLPRDTLALSIPAGLDPLETRILQRRGAFVLPPKTLCDDLIETFFAWVHPIVPVVNRTKFMSQYRDPKSPPSMLLIQSILLAGARISTNPQLMVDGSASTAVATFYRRAKALYDADYERDGITLVQSMLLMGWYWAGPDDISKNMFYWSQSAIAVAQNLGLHRSMENSTLSISEKRLRKRIWWTLFTRDRTLAVGLGQSVSLNLDDCDVDMIADDDFIEHDGNDIHEYPPDPTQVGFFVQYVKLCKLIGLVASKYSNISSGGQDWDGINSIATSLSKWNQECPAPMRWERSKHHFWSGILYLHYFSACCLLHRASSPRNRKTLQDTKQSYGLRDGTVGSANMITSIVEALRDKQQLRRCPPFIVHSLFSAVVIHLHVSNTPSPTTRRLARRRVSTCLESLKDLAQVWAVGRTVVTMIETISGLSCDGKPSSRKGEVVIDLGCADTSDQACSPDSRSITTDVSDKTQALHDPPGSYQTLPYREAYTPVVVDSHTEFPTAYDYPSNFDLGVLPAQIDSSSLLPDAYIHSGLPPGSFYVDDTAQICNPITDASVPSWDQFQMGCQQDYSISVPWSLIPDPPIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWU7</accession>
    <name>S0DWU7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apolipoprotein/apolipophorin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429057.1">
        <property type="nucleotide sequence ID" value="XM_023575802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWU7"/>
    <dbReference type="STRING" id="1279085.S0DWU7"/>
    <dbReference type="GeneID" id="35406606"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13152"/>
    <dbReference type="HOGENOM" id="CLU_033245_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44856" checksum="1770453E7918D1C3" modified="2013-09-18" version="1">MLPARPLIRSTVPRAARASRASRQVRFQSTASSSSSSAHLASGIAGGFVGSAIFYGIYSYTPAGRAASGINKAAKEAQQKYEAAAKKLQKNTPDADQAVNYIKEFAYSYVGWIPGGRAYVDAAFKDWEKVRENNKDEADKLVNDAYKQFQDLSKSGLSLETASKAYDVLADLAKKVANLAGDAIGDIIDNHPQVKEKLGSNVDQLKELGDKYGPEAKKQVDETWKQVKDIFAGGFSAASISKARKLIEEKVEQIKKLGDQAWKKGLEEAKPYLDKNPKVKELIEKNADALKEGNTAELFKRAKSAVDSGDLGDLEKYVKDATEKVKSKGNELTGGWVDIEKYIKEIPNGGEVMEKLQQLSEVADKHKEEGEKLFKETVEELRQVLEKKSEKAQEIAGEAKKDAKKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXR0</accession>
    <name>S0DXR0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428238.1">
        <property type="nucleotide sequence ID" value="XM_023574972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXR0"/>
    <dbReference type="STRING" id="1279085.S0DXR0"/>
    <dbReference type="GeneID" id="35396639"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03157"/>
    <dbReference type="HOGENOM" id="CLU_005049_6_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="11"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="236" mass="26286" checksum="B05950AA1954CB60" modified="2013-09-18" version="1">MATETTPKTIKRLIACCDGTWMDSDNGYEEAGLLRKEGSLQIPSNVTRISRCFEKRCSDGKLQVVNYESGVGTGSNVLDSITGGAFGMGLAERMRETYSFLCSNYMDGDEIILVGFSRGAFTVRSVAGMIGNLGLLTREGVEFFYPIFKDMQHWMDYDYEDPFPNIPFPDKPKGEDAADVYRARLEQLGYTRVRRSEGQGDIITIKAVGVWDTVGSLGIPRVLWLEKLGIRADNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXR1</accession>
    <name>S0DXR1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429435.1">
        <property type="nucleotide sequence ID" value="XM_023576260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXR1"/>
    <dbReference type="STRING" id="1279085.S0DXR1"/>
    <dbReference type="GeneID" id="35407015"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13561"/>
    <dbReference type="HOGENOM" id="CLU_024934_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="467" mass="51795" checksum="4A0400945346C934" modified="2013-09-18" version="1">MRKSTTPQPTGPESISSARVSKLARRPHRKSRNGCFNCKRRKVKCDEVKPACANCVRFGIPCDFAPQPPSSDDSAPHTSPPEILSVLAEPATTPRRGPGRPRKDWAALTRPPPPPPPASDRTTTSPSSTSATPVSSSTVSNSQICSLNIADAELLFHFMANTSRTLHDADDPVDDIASFWARNVPQIGLSYHFVLHMMYALAGYHLVYQEPKGTERHSQSLALAAHHAELGIYEMNRTLTNLNEANCGALYVAAVLVCYCTFAAGPTGPDDLLVCVIGEGISQRWLPVIHGVRLIRQSIEPATLFTGLMAPLGGGGTNSEMEDTKPDFMVMGFSYIDWVGPLEKLRLWIASHENPDTALYLRVHKSLCDVYEANFGNAEGLVQVPMMNKFVFGWLYRMQDLFVGCLQRKAPQALLLMAYYVPLFRTMKRSWFMEGWATHLLETIRGLLNTDLIGWLDWPVEISRQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY81</accession>
    <name>S0DY81_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to uroporphyrinogen III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429496.1">
        <property type="nucleotide sequence ID" value="XM_023576331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY81"/>
    <dbReference type="STRING" id="1279085.S0DY81"/>
    <dbReference type="GeneID" id="35407079"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13625"/>
    <dbReference type="HOGENOM" id="CLU_051874_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000011">
        <property type="entry name" value="Uroporphyrinogen-III synthase (UroS), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="321" mass="35513" checksum="046A90ADD8E30E86" modified="2013-09-18" version="1">MTTTNPTTEQASEIPVLLLKTRSSPGDSYEDLFSESNVNASGFAPQFVPVLLHQFHSDGMNEVAALLRDRRIGNQKHHEYGGLIFTSQRAVEAFVKLVEDGKADDIPKPEEKTSWPHLQNIPVYSVGPATTRALAAVPQEPPLQVFGSHTGNGAALAPFILAHYYEWYGGQKRATLPPILFLVGETRRDIIPKTLQDGALPDTERIRVTETVVYGTGVMESFPVDLRRVLGETRNDSMRWIVVFSPTGCDSMLRVMGILDPETNKVYKGYERDGKTFIATIGPTTRDHLLSFGFEPDVCAELPTPQGVLEGIQAFMVKRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYV8</accession>
    <name>S0DYV8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429827.1">
        <property type="nucleotide sequence ID" value="XM_023576729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYV8"/>
    <dbReference type="GeneID" id="35408139"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14759"/>
    <dbReference type="HOGENOM" id="CLU_061840_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4185" evidence="1">
        <location>
            <begin position="185"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="348" mass="39138" checksum="5E991CE6316BC226" modified="2013-09-18" version="1">MTVDNTQPEGENPIGDIQVEFLGTQKSSNTASRRDLGFTGQLGGKWYAVYGDVLWCDSGVTDPEDDNEGFHGMVRNAVSALTDDPLVVEDLHLNDDEPVPHQKQFMPFNEDWGETNTFGFGGTGIVEVDPDTATGALYYLVNDDEHYKGAGVAKVELIDDIPHITDRYGENGIWWDGDEVPKYGDVATYRDVNSEYIYILGNPPNPIKDFPDKLYIYMARVPAKDAFDLDKYEYWWGRQEGWKSEVLTTFNCETAVMWGVGQGQIVYNNHFQTYFYVHLDLSGTVFLKTAPSPEGPWTEGKEIYKDEPIDGGLVYAGIAYPHLDESGETLTIGFTNNNWIRVIKVTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZA0</accession>
    <name>S0DZA0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_03122</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428803.1">
        <property type="nucleotide sequence ID" value="XM_023574934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZA0"/>
    <dbReference type="STRING" id="1279085.S0DZA0"/>
    <dbReference type="GeneID" id="35396604"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03122"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_1"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT66722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="490" mass="52602" checksum="FB7212B15DF579D7" modified="2013-09-18" version="1">MAAPELTDPTLIRNACYVNGEWVAAKSGKHFAVENPSTLEKIGNCPEFDASDTEAAIAAADAAYKTYRKTPARQRARYLRRWYDLMMENSEDIARLITLENGKPLADGRTEANYAAAFFEWFSEEAPRIYGETIEATNPSCRLSTIKQPVGVCGLIAPWNFPAAMITRKAGPALAAGCTVVIKAPAEAPLTALALAELAHRAGIPAGVVNVITALDNTAEVGKVLTTHPKVKKVSFTGSTGVGRLLMNQSSSTIKKLSFELGGNAPFIVFEDADLDKAVKGVIACKFRNSGQTCVCANRILVHRSIYDKFVQMVLDVVKTFVVGDGFGEKTTHGPLIHGRAVAKAAEHVEDALSKGAKLIHGGERLPHLGPNYFDLTMLTGMKPGMKVCSEETFGPVAAFFAFDNEDEAIELANDSDVGLGGYFFSNNVNRCYRVAEALEVGMVGVNCGVLSDPAAPFGGIKQSGFGREGSKYGIDEFTITKMVMTNIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZG1</accession>
    <name>S0DZG1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427949.1">
        <property type="nucleotide sequence ID" value="XM_023574627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZG1"/>
    <dbReference type="STRING" id="1279085.S0DZG1"/>
    <dbReference type="GeneID" id="35396330"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02848"/>
    <dbReference type="HOGENOM" id="CLU_016581_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="133"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="597" mass="67172" checksum="3665AA46285F8740" modified="2013-09-18" version="1">MIPEKPLPFNGNFSSPEEYIDELLKFVRTSETFQILCGGVHILDFFTIEPGLFHYAIPKEWHAFILSRSLMEFLDLLMRDELDNIKLEGEQPPAGLIDYIRTVRNLSLGRSFTPPSGKLPVLPRSVAVGMNVKKTHEVTNFADYLARLSEDISSQCGYDISHYVDFGSGQNYLGRAMASEPYNRHVVAVEGRENNVTAARGLDVTSGLAVKPKVMRNKKLWTKILEARGPDGQEDPEALAKAIHEIAGDEAFEFRPVKELEAEYTVEKGKGSVQYISGRLETGDLADVIAQINPGSQTEDEKNDLSLMAMSIHSCGNLSHFGIKSLVLNPDIRAVAIVGCCYNLMTEKLGPPTYKHAFLRPTLQAVNGRLVRESEKHDPQGFPMSQKFSAYQGDGVRLNITARMMACQAPQNWTEKESAGFFSRHFYRAVLQKMFLDRGVVKKVRHTGSQEESQVDVAASTQDDSESPFDISTNPVIIGSLRKSCYGSFKSYVRGAMEKLTTNNEYKQYADVMQEKMGDISDEEIERYEALYLPRKKELCAVWSLMAFSAMAVESLIVSDRWTFLKEHDDLVRHAWVETVFDYEQSPRNLVVVGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZK2</accession>
    <name>S0DZK2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430089.1">
        <property type="nucleotide sequence ID" value="XM_023576937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZK2"/>
    <dbReference type="GeneID" id="35400238"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06761"/>
    <dbReference type="HOGENOM" id="CLU_1343276_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="204" mass="22929" checksum="E1EE86BBDE0BA6C2" modified="2013-09-18" version="1">MTAINSAAVFHPTRDFLLFSAAVGLPLNFVRFCIMVRPVAFFTFILLIFSAIFGFTMKRLHRQGAHLKATFATPITDPLNCLIADILMGILSLLTLSFTWTHNRWQDTGETFLVAYSSTPLMFNMFLHFYLALLVLFRTSQMKDIVKELVGDFVSSSPQPCPHCHGRPEYHDEHDEEQALVTPPAGEHEDAHESGAGPATVWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0A1</accession>
    <name>S0E0A1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to C.cardunculus cypro4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_13243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429143.1">
        <property type="nucleotide sequence ID" value="XM_023575905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0A1"/>
    <dbReference type="STRING" id="1279085.S0E0A1"/>
    <dbReference type="GeneID" id="35406697"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13243"/>
    <dbReference type="HOGENOM" id="CLU_007002_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="246"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="424"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="808" mass="91273" checksum="B352A8701EAFCEF2" modified="2013-09-18" version="1">MFALRGIGKLIFGSSTQEALIELPQGQLYLVRPLSPKGYSELIFRDSAIRIRRTNQEFQYQLVVQRVFEEGEAELLAEEEGEDAEIDALASEKDEKTFLLDEALFFRSEIRESGDKVLAWKDLSGDTGDLFQFVCDPSVTTSQVQQFVQVAQQCQYERKYRKSHSTATASDLQQFEFEEEDPIPPASPLHSPTLARSIESVDDMLSKTQANSAAKREPAFVPEQEIEAPVLTGPDASNPPEPLDIYAAVVAELHVFDPQPGHFALVDDSIIAQVSEVGKWEYWLQIESNDKAYLGTPVVADFNPVFDFEYLSFVFNHFSSDGTARSWLLRFKDQPTLEKFQEAIMQAIWEKLNETKWTKMQDKEREYVLDAFGDLTMEDAPSTEEEEEEEEEEEELEDDRAQEEEYDTDEENDSSFPKNADGEVNSQLAVGYKHDRSFVVRGSKIGVFKHTPNNHLEFSTNISKVTTPSGKLMNPKKVMLHSEDRDLILQNEIDPNKLYRMDLEYGKVVDEWNVHDDIPVVTFAPENKFAQMTSEQTFLGVSNNALYRVDPRLSGNKLVDADMKQYASKNDFSALATTEKGYIAVASNKGDIRLFDRLGIRAKTQLPALGDPITGIDVSADGRWILGTTKNYILLVDAQQKSGKNEGKLGFEKPFAANDKPHPRRLALTPEHVAQFYHETGKPVDFTPAKFNTGEGAEETSIITATGPYIIEWNLKRILRGMKAAYKIKRYEEEVKADDFKYGSDKNVIVALPNEVNMVAKQSLRKPTRESIIGNVRLSDSRRGSGRIGTRDSGRYKLGKDDIVNAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1E7</accession>
    <name>S0E1E7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430759.1">
        <property type="nucleotide sequence ID" value="XM_023577744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1E7"/>
    <dbReference type="STRING" id="1279085.S0E1E7"/>
    <dbReference type="GeneID" id="35400963"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07486"/>
    <dbReference type="HOGENOM" id="CLU_057546_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF73">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="149"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="276" mass="30525" checksum="10CC42EF996A582E" modified="2013-09-18" version="1">MALSRAEIESITAVHVREPLPADTLTATFNSKPFIPIESIINLRDLGAVPGSAIRPGHIFRSGMLDTAADVPEAMAWLTANVKTVFDLRSKEERATYPSPKITGVNFVFCERVSEYPQPSPADFALDDGRTAWREQLMAVIAAYKPSIRAILEHVRDKPNEPFLFHCTAGRDRTGVMAGLLQTLAGTSQQDVISDYMLSRIGIEPARERLLLFILANIDVKSTEEPGFWNMVGLRPSFWEAFGQGVEAEYGGWDGYVKGLGFSAKDLETIKHNLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1I9</accession>
    <name>S0E1I9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable C4-dicarboxylate transport protein mae1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_13464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429613.1">
        <property type="nucleotide sequence ID" value="XM_023576153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1I9"/>
    <dbReference type="STRING" id="1279085.S0E1I9"/>
    <dbReference type="GeneID" id="35406918"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13464"/>
    <dbReference type="HOGENOM" id="CLU_030057_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF3">
        <property type="entry name" value="TRANSPORTER_MALIC ACID TRANSPORT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="493" mass="53849" checksum="99009C98C1D6BA6E" modified="2013-09-18" version="1">MAPASDPMVAGAELQPPSPSPVPPSGSTSALATGYESPSEENPPFFSVVASAPAAPGTAHSRHHVVPRPALSQRPSYITAIPPEHTNGHARPGRLLNNESALTSNSLNHVIATAEKGPGNQKVGIRDRIACYQWTYFTMTMSTGGIANIIYSLKWEASWLRGIGLFFFFLNIVLFAMNCILICTRFHLRPGSFVNSFTDQVESLFISASLVSIAVILINTCQYGIPHTGIWLVHTMECVFWVYAALSVSLSAFLYLILWSTLIFPVHTMTPTWVFPAYPLLLNAPFAANLIAAADSAGHKLSTNTVAMALGATAIQGTGCLIAFMISSAFIYRLMTQKLPRDMQRPGIFMSIGPYGFTAAGIAQLGSQADLVIPPNFLDNPQFAAIIKVISILVSLWLWGLAMWFFIVCVGALWKYSLSGHHLPFQMTWWSFVFPNTALVTATSVMGKIFDSNGLHIFASVMTAAIIIVWALIFIRMCWSLKSRKLLWPKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1Q3</accession>
    <name>S0E1Q3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430791.1">
        <property type="nucleotide sequence ID" value="XM_023577781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1Q3"/>
    <dbReference type="STRING" id="1279085.S0E1Q3"/>
    <dbReference type="GeneID" id="35400997"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07520"/>
    <dbReference type="HOGENOM" id="CLU_052200_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="431" mass="47601" checksum="457309447F43DAEF" modified="2013-09-18" version="1">MPQSLARAFTVASSHERHIILSDISQHFTIETVKVIIDSVWLRTHTDLRRQGILSKQYLHGKCVALYSGHVHSPYTMSPPPSTPTPKRFLLPKRGTQSSQNPATLPRFQSTPRFAPPSVPRPTQARTGIDIEDVEEVGDNSQENLLESDEHQVQLRKHDSIHDSIEIESDDATASQGGNIVISDNEPDDVLQDSLDLEMSNSTPSHYDSPSLEEREPKRRRVSSSPRRECSTPEEQRNPDNESPEEAYKSGLTPSGESTQSIQDAINLNNELKPLQQPTFHAPPRFKPVDLDPAVDGLPAAFSPQRRGVKYMAGGLAADLQGWLSEVKGWEGAAPATTVTKKVIIEEIRPGRRMYLVKARTGASEEGRYLLVGEGRLTGLGQRMPVIIGSVVDVGQPVWDIMLDGQVWTVACDWGISESGNTGEMTHLSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1V6</accession>
    <name>S0E1V6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to the plant PR-1 class of pathogen related proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430919.1">
        <property type="nucleotide sequence ID" value="XM_023577936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1V6"/>
    <dbReference type="STRING" id="1279085.S0E1V6"/>
    <dbReference type="GeneID" id="35401136"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07659"/>
    <dbReference type="HOGENOM" id="CLU_035730_6_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485193" evidence="1">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="41"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="202" mass="22477" checksum="42C097CAD8F25970" modified="2013-09-18" version="1">MKNLLFPLTALLVGPSLAADVTITAPVSIPSNEPEYKEGKSFTSAVLNSTNFYRQEHNATALNWNKTLEEFATDYLDDNDDCDFEHSGGPYGENLAIGYPNVTASIEAWGDERDEYNFDKAKFSKKTGHFTQLVWKDTTTVGCGRKLCGERGWFLVCEYWPRGNVEGQFKEEVSKEEGGAFSTRPGLGLALALFIGYMLVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E205</accession>
    <name>S0E205_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable RRB1-involved in the regulation of ribosome biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430964.1">
        <property type="nucleotide sequence ID" value="XM_023577991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E205"/>
    <dbReference type="STRING" id="1279085.S0E205"/>
    <dbReference type="GeneID" id="35401186"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07709"/>
    <dbReference type="HOGENOM" id="CLU_025272_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="5">
        <location>
            <begin position="95"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="299"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="394"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT68884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="487" mass="53691" checksum="10F3D91DAFA65D22" modified="2013-09-18" version="1">MAKRTAEADHGDALKGGERPEKMDIDDNTKEMGEFEDEFEDEFESEDEILEAGVDGRPDAEREAEEKDAMEVDQGTFIVGRSKLEPGQTLAPDLTTYEMLHNLSTPWPCLSFDIIRDNLGDNRKAYPATMYTVSGTQAETGKASDNQIMVMKFSGLSKMDRGDEGSDSEDDDDEDSDPILESKSIPLNSTTNRIRAHQIPSQEAGRPGTTLTATMTESSNVYIHDITPHLASFDNPGTTISAQQNKPISTVRAHKTEGYAVDWSPTVPGGKLLTGDNDGLIYVTTRTDGGGWVTDNRPFQGHTSSVEELQWSPSEQSVFASASSDGTIRIWDVRSKSRKPAITMQVSNVDVNVMSWSRQTTHLLASGDDNGAWGVWDLRQWKASSDKPQPIASFNFNKEQITSIEWHPTDDSIVAVAAGDNTVTLWDLAVELDDEESKDTAGVKDVPPQLLFVHYLKDVKEVHWHPQITGSLVATGEEFSVFRTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>S0E243</accession>
    <name>S0E243_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_03388</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428819.1">
        <property type="nucleotide sequence ID" value="XM_023575231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E243"/>
    <dbReference type="STRING" id="1279085.S0E243"/>
    <dbReference type="GeneID" id="35396870"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03388"/>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="254"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT66738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="456" mass="51003" checksum="07B53650D7DD6A18" modified="2013-09-18" version="1">MREIVHVQVGQCGNQVGSSFWQTVSGEHGVDGSGSYNGTDDQQRERIDVYFAEARLPLSLTATKDKYVPRAVLVDLEPGPQDAIRAGPLGQLFRPDNFVAGNASAGNNWAKGHYTEGAELVEEAIDVVRHEVENCEHLQGFQLTHSLGGGTGSGMGTLLLSKIREEFPDRMMATFSVMPSPKVSDTVVEPYNATLSLNQLVENSDETFCIDNEALYDIYEKTLKIADPSYADLNYLISTVMAGVTTCFRFPGQLNSDLRKLAVNMIPFPRLHFFMVGFAPLTGRKMQGFQHLTVPSLAQQIFDNKNVMAAADFRNGRYLTCSAIFRGKLSTKEIEDQMLKVQTKNSEYFVDWIPNNVQTSVCSVPPRGLPMAATFVGNSTAIQEIFKRVDDQFSAMFRRKAFLHWYTSEGMDEMEFTEAQSNLHDLVSEYQQYQDAEIDDEVEEYEGEGEPEEYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2B9</accession>
    <name>S0E2B9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431059.1">
        <property type="nucleotide sequence ID" value="XM_023578214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2B9"/>
    <dbReference type="STRING" id="1279085.S0E2B9"/>
    <dbReference type="GeneID" id="35401386"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07909"/>
    <dbReference type="HOGENOM" id="CLU_008699_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="662"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="849" mass="91167" checksum="8E379BDB1D5385F5" modified="2013-09-18" version="1">METESKPSDMGTPLSSTLSSLSDSDSDAEVSKAAGPNNDTDSQNNNEDTVEWLATTRKRRSTAGNRMKSMLANEEPDSDLELLFAEDENDQGFSDAEENGSDVQMDSSDDEDENDHNDDDLEGEKELEKQAKERRAAQRKRKAQEAIPAKFRKKVRIDPTTRTPAPVKPAPRPKKKSERTSWLPSAADLPTRASSRQTTRLSKEQLHQQMVEREARRIKQLAQMQKKAAKLEAMKKPPMTQEERLREAAIVEKRNSKSLNRWEEAEKQREEERRAKLAALHNRTLKGPVITFWSGIGEWMGRHMVIEEPAKEKRKRGEKAKGKDKDKNKEKAGPIEDKKEDGQNGTPATNGEIVNAEEGSQPSQDIPPSITSAEPTAASDSKDTKPATPPKPVEDVTKPTDASSTSETNGAPPAVPKTEDIPPPMTMPPPPQPPPTPPSSLAAPAHLPSTFVPAPSPPRSQDPPSGLAAPPPPPPTPAGSVSTTNSFVAPPSGLSRPPDSKPSGVLAAPILAPPPGIGINGNAPPMMGFGNPKSNVLAPPNTSQGAMPPTLTATAPLHNTPPSTISPPPSNPSTGVTSISSTTNIQPKTITPVPPTKSTSPGTPAIAQAPDSQTQPSQPSTGARNAIVFQNFDDNALKDRSIQTQIIFGRKMNKLSKPSPAPLCVITNHPARYRDPRTDLPYYNAYAYREIQRLTRGEYRWSHILGAWVGSGTYAARGVPERFLNPDKKGPEKKSTPDEGLKGKDAVKAPDQAQDPQTKPPDVPSGIPTTGDKMTGVEQGASALPNSEPNQTIQTKMAPQAVTQPTEATNATAATPEAPNITPAPKAQAPTNPQPTTAEKPLSPLQTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2T7</accession>
    <name>S0E2T7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to SER33 3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_08053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431196.1">
        <property type="nucleotide sequence ID" value="XM_023578376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2T7"/>
    <dbReference type="STRING" id="1279085.S0E2T7"/>
    <dbReference type="GeneID" id="35401530"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08053"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12160">
        <property type="entry name" value="2-Hacid_dh_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="142"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="353" mass="38901" checksum="46F1FD56EC46B905" modified="2013-09-18" version="1">MLPIMRSSPRFGIRTYTSRSLQTPLSRRFISNSYSQLPAMKLLYPTSLKLDVQSLEGFSVDLFPYDVKKTIPEEHVDAEILVTWTNTPENLKDAAKRLTKLQWIQSLAAGPNDVLGAGFDASKIKITTGSGLHDHTVAEHALGLLLNAARRFYEMRDYQLQGKWPGHLGGPQPDRPKNAFTTLRDARVLIWGFGNIAKTLTPQLVGLGAEVRGIARRKGVRNGIEVYSEDDLDALLPETDALVMILPGSDSTRHVLNAQRLKQLPNHAWVVNVGRGTSVDEDALVDALEKGEIGGAALDVFETEPLPEPSRIWKAPNTIVSPHAAGGRPQGAEGLIADNLRRFRAKQELKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2W1</accession>
    <name>S0E2W1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_06728</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT67977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430057.1">
        <property type="nucleotide sequence ID" value="XM_023576900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2W1"/>
    <dbReference type="STRING" id="1279085.S0E2W1"/>
    <dbReference type="GeneID" id="35400205"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06728"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="18"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT67977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="355" mass="37318" checksum="CB7EEBDD28121CB8" modified="2013-09-18" version="1">MGDATAEEPYHRVATVVRSNEGFQFKINSVPIPKLQPWEVLVKLSATGVCGTDMALAGGYLGPCREVLGHEGVGRVVQVGSGVDPDSVKIGDRVGIAWVRDVCGRCNCCREPGGEVHCLEQQNSGRKWDGTFAEHCIVPSRYVLTIPESKELPDELVAPTLCGGVTAYKALKACGATPGEWVAIVGAGGGVGGLGIQYAKAMGFRVAAVDIGPAKESCIKMGADVYFDGASPDTPAELRKLTPNEAGAKAVIVTAGSGRAYQSALDLVAVFGTLVCVGIPPPDQAMSLHPLILIDRGINLLGTLVGTRTETLEALEFVRRGVVEPVVESVSFDQLDDLVNQFSKTSGKLVIQFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E399</accession>
    <name>S0E399_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to laminaripentaose-producing beta-1,3-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431220.1">
        <property type="nucleotide sequence ID" value="XM_023578405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E399"/>
    <dbReference type="STRING" id="1279085.S0E399"/>
    <dbReference type="GeneID" id="35407821"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14370"/>
    <dbReference type="HOGENOM" id="CLU_032886_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd09220">
        <property type="entry name" value="GH64-GluB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="entry name" value="Beta-1,3-glucanase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165:SF1">
        <property type="entry name" value="GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52006">
        <property type="entry name" value="GH64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485558" evidence="1">
        <location>
            <begin position="17"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="GH64" evidence="2">
        <location>
            <begin position="68"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="445" mass="47746" checksum="ED9ED3A762E93E42" modified="2013-09-18" version="1">MRSFFILACLLGTALSAPFKTSSLDTTREGFLKAHPGGTNNVEVTDNNLLNGTYARNKTRVLTHRAEQATLPLKLVNNFSGGNVRAYISGLDSDGTVVFIGANGNLVYPKSGGSKVPVEIKDNIAIPLPAQGQTLEFTVPISMSSGRVYFANEDLHFFVVDIGTGDGLVQPSVTNLQDPSAGVDWGFVEFTYTNGVLYANISYVDFVGIPLGMGLSLKDGSTQSCAGLESGAVSKICDDLVKQKDKDGRAWTFMCIANAQGKPVRVLSPGNQYDLEPITFGDYWDTYVNNVWSKYSSQDLIINTQSEAGNVKCRVTGDQLTCDGDNRGYGKPNTKDIWGCNSGPFTVMEGDNAVHAAVVPRLCAAFVRSTLLVDGGDTQPKLGQEAYYKNDPTNHYSRIVHSYEVDGKGYAFPYDDVNPDGNENASGVVSGVPETLTIFVGGPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4D9</accession>
    <name>S0E4D9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431681.1">
        <property type="nucleotide sequence ID" value="XM_023578716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4D9"/>
    <dbReference type="STRING" id="1279085.S0E4D9"/>
    <dbReference type="GeneID" id="35398978"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05499"/>
    <dbReference type="HOGENOM" id="CLU_036417_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="422" mass="47782" checksum="B4AA6AFD0FC2DFAD" modified="2013-09-18" version="1">MSVLFVLLYVSKGNVLRRCLSKRLNADDVAFLELFSRILIGRGNCPDEISKALKKGIELEWEDVYDLVNPFGDKRGRAFNSVWTFDLDKDILFLTKHDRLCSAPLRLARERILTLDDFEILKSQTETIAEEGLVPRLYWDLQPKVDDRKRAFLGRILRDLGHTWRHVLRAEMNNITFTKLAYAVIWIINLDFTVVERTGFEHVGGRGGPYVGVADLPPWDAPDETIVRVGTCWIFLARDIPKGIKMIREHVETRATMTGTATYAILTLRQIACCKVHDGELVYTRPEPLFSDTLPSDSAIDLLLWASDLHQAEPKPRRLSHLPIEIQDRILRQASISSVAAAKLGIELALGSPFSWAEQGRKIKLAEVLRHRTEASPVESQFFFDGLMRGLSYKCESMSNGFKVDMSSLPAPPHRNGAVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5C1</accession>
    <name>S0E5C1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to DUF718 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432143.1">
        <property type="nucleotide sequence ID" value="XM_023579276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5C1"/>
    <dbReference type="GeneID" id="35399478"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06000"/>
    <dbReference type="HOGENOM" id="CLU_100689_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="119" mass="14116" checksum="AE7FB2E66D802DBF" modified="2013-09-18" version="1">MSQTARRFAQIVKLRPQHLAEYKEVHARVWPDVLKQIQECNIRDYSIFYDDQSHILFASFKYIGSDYSGDMEKMAKNPRVREWWKMTDAWQESLVPGAVSSEAGEPSWWKPVEEVFYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5T8</accession>
    <name>S0E5T8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to Zn(II)2Cys6 transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_14855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430028.1">
        <property type="nucleotide sequence ID" value="XM_023576845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5T8"/>
    <dbReference type="STRING" id="1279085.S0E5T8"/>
    <dbReference type="GeneID" id="35408233"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14855"/>
    <dbReference type="HOGENOM" id="CLU_011017_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="574" mass="63748" checksum="59FB44DABEA259F8" modified="2013-09-18" version="1">MSVSEGSPSQSHSQSPQAPSSSESDLGPLSPWSCQRCRVRKLKCNRVLPICGRCVKIGEVCDYPSARKKPVINPANRPRLRDMQSRIRDLEARLEAQSSPPEFQPFSTSTELVDTGRFEGLPPPHLVDELTSIYFTKLQSDSFMIHGERYIASLYRPAHMQPPMCLQYAILAAGASASPTYKPMAEAFYVRARQYIQADEMKSDSDQISLAHCQAWVLISHFEAQHLWFSRASMSIARAIRLAQILGLHRLDGKNAAGLTLPIALDFTEEEERRKTFWVIFTTDRITSSTGGWPTMMDWRSIQTRLPSSIDALLSNTPIATLTLRQALGQGMYELSTSACRVVAVHLFNECFNFSRNVEEDADNNDWHQLQQLDEAVTNAFATLPLDLRCPENMESPEAVLINLQLHTALICIHQSALTRSQVDMAALPTTKARVMESAVQIMITVALVTDLNTRFRNPLVSFASFIAASFFLSDFLTTGDLQSEANFTALMTVMVEVGKNNMFAASLAVRLAQTLRASGVDQETAGKVGVMMADLNIDHPIPGQEDKENGIVILCPTATTPEQVDFDQGIVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E654</accession>
    <name>S0E654_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to integral membrane protein PTH11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_06113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432244.1">
        <property type="nucleotide sequence ID" value="XM_023579401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E654"/>
    <dbReference type="STRING" id="1279085.S0E654"/>
    <dbReference type="GeneID" id="35399590"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06113"/>
    <dbReference type="HOGENOM" id="CLU_019101_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT70165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="372" mass="40839" checksum="0049479D64B98DC2" modified="2013-09-18" version="1">MATPFQTEAWTEYGLGTLVLFLRYFARWKTVGFKGYQGDDYFALAALVFWTCELVMLELIGQSGTNIGVTDEMGANMSAAEIAKREFGSKCLLAGWNFYVTLIFTLKGVMLCLYSRMTLGLWQRKIVIWTQVGTVVAYIAVMAAIWGHCTPVHKNWQVYPNPGDTCTLAVANYLTLVVFNIVTDIAIVSIPVPLLWTVKLTIKRKLMIGVLLCSGVFIMVATLLRCVFSLRDIQGINTSTIWAIRETFIAILAVNAAAIKPLFSASRWLVSSKGSSRDKGTSSYINKHGHPLGTIGGSGISGGISANRHQKYMTQLDDNSSEEHIVGKPEFVGYSKPEVRAGSTTSGQSDNQDGIMVTRTYEVTPGKPTLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6N7</accession>
    <name>S0E6N7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to glucosidase II, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_06320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432434.1">
        <property type="nucleotide sequence ID" value="XM_023579632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6N7"/>
    <dbReference type="STRING" id="1279085.S0E6N7"/>
    <dbReference type="GeneID" id="35399797"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06320"/>
    <dbReference type="HOGENOM" id="CLU_000631_7_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06591">
        <property type="entry name" value="GH31_xylosidase_XylS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="231"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="576"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT70355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="663" mass="75894" checksum="56E4DDFA89656415" modified="2013-09-18" version="1">MFFNDKTRLRYKYDAEELWIEPWGPNAFRVRATKAAAMPSQDWALQKLTEVTPEISISDESASIKNGNIKARISRQGKLIIEKADGKLILEEYSRHRRDLLDPKCSALEVEAREFKGILGTDNYHLTMRLESVSPEEKIFGMGQYQQPWLDLKGLDLELAHRNSQASVPFAVSSLGYGLLWNNPAIGRAVFGKNIMSFEAFSTQILDYWIVAGDTPAEIVEAYADATGKVPIMPEYGLGFWQCKLRYQTQEELLEVAREYKRREIPIDLIVIDFFHWPKQGDWKFDSDYWPDPDAMVKELTDLGIELMVSIWPTVDKTAENYQYMLEHGYLIRTDRGVRIGLDFQGQTVHIDTTNPDARKYIWDTVNKNYYSKGIKTFWLDEAEPEYAAYDFDNYRYWLGSNGTIGNIYPVNYAQAFYEGQEAAGQKNIVNLLRCAWAGSQKYGALVWSGDIASSWSSFHNQLCAGLNMGLSGIPWWTTDIGGFHGGDPNDEGFRELFVRWFQWGAFCPVMRLHGDREPQQPQQGTTGGATCRSGAPNEVWSYGPQVYDICVKYIKIREDLRPYTRKLMKEAHEKGTPVMRPLFYEFPDDKKSWEISTQYLYGDKYLVCPVLKPGQTKTEVYLPKLSNGEKWSSFNGNESYESGVTVTVDCPLAQMPVFVRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E884</accession>
    <name>S0E884_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to YER185w, Rta1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432076.1">
        <property type="nucleotide sequence ID" value="XM_023579193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E884"/>
    <dbReference type="STRING" id="1279085.S0E884"/>
    <dbReference type="GeneID" id="35399405"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05927"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF7">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="346" mass="38114" checksum="BB2C84C42D784D3E" modified="2013-09-18" version="1">MQPTSPVSLNGTQAPDMPFFCLQNPEAGSCVDDTGYYLYRIDLAPNAAFLAMFTVSLIGFIVTWVFTRRGTAFNVAMILGLLCEIIGYSGRIASWYNRFDMNAFLTQICCLTMGPAFMAASIYLCLRRIVSAFGPENSRLPPEYYTRLFIPCDVVSLVLQALGGGMASVASQQYKSADLGTNIMIAGLAFQVATILAFIACSIDFAIRAIRRQRVLGEAAFDQRPEIVKVRNSRRFKAFLCALSLSAICILWRSAFRVAELSEGWKGPLMGHQYMFVGFEGILIVVAVAVLNIFHPALCMKELLEMDGGGLKGIWGFRKRKNNAMTSEESVEDSDRKTPTSEAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8N9</accession>
    <name>S0E8N9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_08707</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433318.1">
        <property type="nucleotide sequence ID" value="XM_023580560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8N9"/>
    <dbReference type="STRING" id="1279085.S0E8N9"/>
    <dbReference type="GeneID" id="35402183"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08707"/>
    <dbReference type="HOGENOM" id="CLU_037162_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="254"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT71239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="416" mass="45477" checksum="371CF4047DA8D3E6" modified="2013-09-18" version="1">MSTTTSGPGLPEIAVLQTDDSMLTRRFGKEVVNYYAGGRINRYSFLRADTGFLRQAFSSPTARYLALHDLNPLVVDKKTPAYLTFKDVEPLIGPDHFALTEDEAIQSFNSAETRPLVVFVGMLEEGNEKDSIPSSDHGDVQGHPYFAIDITPKGNHAEKATQFLEEQEKKGLSLDKNPRAMNQSPEAAALYAQARSIIDWNTRSPFCAGCGLPNLSVHAGYKRVCPPADKKGGASSEPRGDCPTRHGVSNICFPRTDPTMIAAVVSADGTKILLGRQKRWPPHWYSTLAGFLEPGESIEESVRREVWEESGVRVGRVVIHSSQPWPYPSSLMIGAIAQALPGDGEKISLNDKELEVAKWFSMDEARQALKNGTSSLGEPAPEGYKEGDLRLPPPQAIANRLITAVVEGYLTVGPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9L1</accession>
    <name>S0E9L1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431243.1">
        <property type="nucleotide sequence ID" value="XM_023578432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9L1"/>
    <dbReference type="GeneID" id="35407798"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14346"/>
    <dbReference type="HOGENOM" id="CLU_177933_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="84" mass="9500" checksum="5F96B03E8DEDFE3F" modified="2013-09-18" version="1">MCCGRKDPTSKLSAIPPSLRTPNISSYTEDQELRQDRIIHNMGCANMGLSEEKQRAMAETFHDGIRTAKDRDECQSQIDTHPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9N0</accession>
    <name>S0E9N0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433643.1">
        <property type="nucleotide sequence ID" value="XM_023580960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9N0"/>
    <dbReference type="STRING" id="1279085.S0E9N0"/>
    <dbReference type="GeneID" id="35401825"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08349"/>
    <dbReference type="HOGENOM" id="CLU_025711_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21505" checksum="BCC6F5347908248C" modified="2013-09-18" version="1">MHILLLSSSNHNSARIIQSALSRNFTIAFLTPQASQIPHHANVTPINGLPASQHDLEIALQTPRPPEAVILAFYNTHVLEAVTHTLVRALKAIQTAKVNNEKEAAAMPLRLVFIQSNAMQLEADGYKRVDKIVRASGLPFDLAQCPRLAGELSATVRASPEEGRVAAWLATVKKARMAQSGKIKHGEISRTEVKNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAI6</accession>
    <name>S0EAI6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable chromatin-associated swi6 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_06293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432851.1">
        <property type="nucleotide sequence ID" value="XM_023579602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAI6"/>
    <dbReference type="STRING" id="1279085.S0EAI6"/>
    <dbReference type="GeneID" id="35399770"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06293"/>
    <dbReference type="HOGENOM" id="CLU_045874_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18657">
        <property type="entry name" value="CSD_Swi6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT70772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="246" mass="28009" checksum="A804F1E53EE7E36C" modified="2013-09-18" version="1">MPPALSDEESSDVGEFTTPPRASSRKKSTSAAAVDELDDMKPEPASDEEEGDEDEDLDEDEFVVEAIKKHMVYDDGSLQFQVKWEGYEAKKDLTWEPEENLRESAQEILDAYFEKFGGREKLFEEHETASKTKKRRRATTNGTPSTTSTAKRSRREHPANSATPATAKNWSPPAGSWEEEIETIDACEDEGSGKLIVYLIWKNGRKTKHDTDVIYKKCPQKMLRFYERHVKIIRDENKALVDGTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAI9</accession>
    <name>S0EAI9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434004.1">
        <property type="nucleotide sequence ID" value="XM_023581285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAI9"/>
    <dbReference type="GeneID" id="35407536"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14082"/>
    <dbReference type="HOGENOM" id="CLU_063710_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495774" evidence="1">
        <location>
            <begin position="20"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="305" mass="32972" checksum="3EBEF3F47899927A" modified="2013-09-18" version="1">MKFVSILPIFGLLMPLCWAQADPNTLARYNPANRTMSANTTYCLVPISKTLVKTITGYNPLDIDTDILPSFPTGKHPLIVQAGYNKDIRMTALNLVPLQIDSLMQGSLIVPFVDVTKDGQTPIGVPVNYYIGGTNGQPLQAIVPSVASGVSPFEGTTIFPATFSPDTSAARALPNGFNSIQVKPFLLPNTISGPGIYAEAFDMSFKITDSSPYTAHTFHSLLNIPQLLNTNKCQRNTVYFNESSSEPQMVTGEVTLYHQILATPPQGLEGVYRDVYCYSANGQIVSSVGEPCKEAAANMDPEAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBZ2</accession>
    <name>S0EBZ2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NUP82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_08622</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433396.1">
        <property type="nucleotide sequence ID" value="XM_023580655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBZ2"/>
    <dbReference type="STRING" id="1279085.S0EBZ2"/>
    <dbReference type="GeneID" id="35402098"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08622"/>
    <dbReference type="HOGENOM" id="CLU_009483_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT71317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="890" mass="98418" checksum="D2800A64DE82B14E" modified="2013-09-18" version="1">MPKVKSYSAAWLSSNALGHRLFEPSSEASKSRSLEPAYSSKKKTIPGPRRTIAHRGTEVFAAVGREIRWGDLAYLKDEWTNRYPKRGSSQGIRIKREDSTQPFDNENLENAAGLRTIKTPVADDIRQLIMSPNSNFLAILTTHTVHICVLPDPSHLTSEDAGPLKPKIFTLGPTTHVTSRSPIVSALWHPLGVSGSCIVTTTADAIVRVWELSTTDRWSFDSPTTSVDLKKLVDGTTLDQDFSASTATTNTAFSPDSFEMEVAAASFSTKGAGGWNPMTLWVAMREGDVYALCPLLPQKWAPPPTLIPSLSVSIVTTVASIEDDPDVGEQEKLLAQQQLEWMGELDSQEPTIMEGPIGEPMMEIYTRPTRPGIVPRLQGPFELQSDPDTGDELDTSVTDMLVIGKKTETEQLMMGEEEDLDMDDGDQEGLSLTVLCLLSTSGQVRVYLDLEGVQAQWLPPKNKNKLGRLLAEAETPSLLSFQAIDTMTPVEVNDDSWPVFSNDVTSRYNFFVTHHAAITFISLTSWIFRLESELNGDSEAGTDFRIGLLVNSQSTRDRIYSQPTADIAVPLAACNVLRDPDVGYFLLSATPYEPIALTFDTPEVDLAPIRQESPNYEREASMAPLDFYEPRPVFNPSHTFDEGSALPTLLERLRTSRHKTVVNQEVRLSPLTLQIFTDAHKVLADETHRLGMAAAEVFRRCELLQSELKQQVMKANEVKGKIDTINGSHRDGEADNAMYDRRVTAARDRQERLTGRLENLRKIVGKATTRDLSAKERAFVEEVKSMEASVSAPDYAELASGKSKATPAQAKQLWKRLEDIKHLQANLTAEVEAMNKATGETDGPATPSTELRIPQEVRRAKLQQVQGLLSRETALVDAVTARLERLQTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC26</accession>
    <name>S0EC26_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_13816</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="15"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434258.1">
        <property type="nucleotide sequence ID" value="XM_023581581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC26"/>
    <dbReference type="STRING" id="1279085.S0EC26"/>
    <dbReference type="GeneID" id="35407270"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13816"/>
    <dbReference type="HOGENOM" id="CLU_006412_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000057">
        <property type="entry name" value="Vacuolar membrane protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="195"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="20">
        <location>
            <begin position="476"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="19">
        <location>
            <begin position="798"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="611"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT72180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1034" mass="115749" checksum="144B4A446DB95ED9" modified="2013-09-18" version="1">MRAKNPLAFRPGPVSFWTTVIYLALFIPLIWVHETVPSAPADRSLYQGLNLTEAWLDLQTITRAYHPYNSHENDRVRELLINRTKEILDRNDMSYTTETIGGVVWHSRTSSLENQDSPVSAQDKPRGATLFDDRTSNVSWTYNTARRMGSNISKGTWLGQYFEGNNYYVYIHGKNDPEGEWWRDESKYKKFRGEGGVLVNCHFDSVSTGYGATDDGMSCVSMLQLLSYFTLKGRQPKNGIVLLFNNAEEDGLLGARAFGYSPLLLFIHTFVNLEGAGAGGRALLFRTTDLQAAKAYSKSPHPLGSVVAANAFERGVIKSATDYEIFADAYGQRGLDIAFYEPRARYHTNQDDTRHTSVNSIWHMFSAALASTEHLSKTTGTIFNGDRSDGNSDLAQNGKQAEGVWFDIFGAAWAVFALRGLFAWSLTLLVATPLILIAFTYILARKDKYYFFSRDIKMHHDINDDPVVLGGWKGFFRFPFALAFAGALTIASTLLIAKFNPLIIYSSGYAVWSMTLSIFYFSFWLIMRGASFVRPSALHRGFVLMWLFALGWGVQVVCAVAEDRMHIGALYATVFFQSAIFLALLISLLEQFALLGKHDFAMQLHDAHQARDVSSRDTEQESRQQTESEPAHAEAEDDEDRSEDATETTPLRAGESGYGSNAPTSFANTYRRSVAENSPSPPSMRRYQPFEHEQSWSGRLPTWTWILQFLFLAPVPVILFGNIGLVVMSATQMTGTDGGSLLVPVLSLGILSIFLLLPLTPFVHRVTHHIPLFLLCVFAGTFIYNLIAFPFSDSNRFKFYFQQVIDLDNGTNTVSIVGLEEYARSVISTLPSTLGQEIKCQPAVGRDLSDCQYDASSLTPRLYRNKTPDDLISVETIYGSDGSKARLRIDAIDSRLCYVRTSRPIYGFAVDGASPRDPRFGKFPSEGFSSVQLWRRDRDRPWTLNLYLNEANTLSVLDDTTQKEVESQGGHELRVRSAEQAVDRLEVTVSCAYSDANTPGTIPALDELLKYMPTWAAVTKKNVGLVEVRKTHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECM3</accession>
    <name>S0ECM3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to TMS1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023581840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECM3"/>
    <dbReference type="STRING" id="1279085.S0ECM3"/>
    <dbReference type="GeneID" id="35405712"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12256"/>
    <dbReference type="HOGENOM" id="CLU_029574_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485772" evidence="7">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT72390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="475" mass="51527" checksum="68633BA4305C89A0" modified="2013-09-18" version="1">MGALLSLPLLAVPSIGTIASFAASCCGAATCSMVCSACGKCGNSIATRIAYALLLLVNSIIAWIMLTPWAIKKLQKLTLDYVTINCPTGECHGWFAVHRINFALGLFHLILAGLLFGVATSKNPRAAIQNGYWGPKVIAWLAFVVLSFLIPDSFFLFWGNYIAFAAAMLFLLLGLILLVDLAHNWAEYCLAQIEDTDSRVWRFVLIGSTLGMYIGSLAMTIVQYIFFARGSCSMNQAVITINLILWLGISVISVNPTVQEFNPKAGLAQAAMVAVYCTYLTMSAVSMEPNNECNPLIQGQGTRATSIVIGAIVTLLTIAYTTTRAATQSLGLGNSNGIQLPDDDEHGLVTQQPSARREMRAEALRRAVEEGSLPADALLSDDESDAGDAPAGDDERNRTQYSYSVFHIIFFLATAWVATLLTMNFDESTKDGDFATVGRTYAASWVKIVSAWVCYGMYTWTLVAPVVLPDRFDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECS6</accession>
    <name>S0ECS6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable hydrolases of the alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434829.1">
        <property type="nucleotide sequence ID" value="XM_023582274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECS6"/>
    <dbReference type="STRING" id="1279085.S0ECS6"/>
    <dbReference type="GeneID" id="35406099"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12643"/>
    <dbReference type="HOGENOM" id="CLU_048587_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="93"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="345" mass="38073" checksum="F040A9FE3CB834F0" modified="2013-09-18" version="1">MKSILNYAGQGIMAFAAAMPASAQNLSYGADNFYRSEDVAIQPIHFNTIYNTTIVGNLFTARNASLNASSPAIVVGHPMGAVKEQSANLYATKLAEEGFITLTLDLPFWGRSDGPQNLVSPDFYTEAYSAAVDHLGTYNFVDRDRIGALGICGSGGFVINAAKIDARIQAIATVSMYDMGTVNRQGLRGATSVEQRRAIIANASQRRWAEVDGAPTGYAVGTPNELTSQSDDVAREFFDFYRTVRGEFTPEGWQRNQTTHPSLITNVNFLNFYPFNDIEIISPRPLLIISGDQSHSREFSENAYRAAGEPKELYWVRGASHTDLYDRTEVIPFSKLNEFFQENLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECV1</accession>
    <name>S0ECV1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative aldehyde dehydrogenase FUS7</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fusarin biosynthesis protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_12325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative aldehyde dehydrogenase; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C. Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production. The other FUS cluster members are not essential for fusarin C biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434528.1">
        <property type="nucleotide sequence ID" value="XM_023581919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECV1"/>
    <dbReference type="STRING" id="1279085.S0ECV1"/>
    <dbReference type="GeneID" id="35405781"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12325"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="30"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00078750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT72450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="484" mass="52848" checksum="8AC1EC2E3F706AB1" modified="2013-09-18" version="1">MATNGTKSHPINLKDNYVQIIDGKSAPTQKSHQGINPATLEKKPPVPVATQDDLNRAVDSARKAYKSWSKVPWEERKQKLFAWADAIEAQKKEFADLLVSEQGKPIAQASGEAEAAIAWVRGQASIDLPEEVVEDSESRKIITRYTPLGVAAAIVPWNFPLMLAAAKIAPALVTGNVIIVKPSPFTPYCGLKLVELAQQFFPPGVVQSLSGDDNLGPWITSHEGIDKISFTGSTNTGKLVMQSAAKTLKRVTLELGGNDAAVVFPDVDIESVAEKVSTLAFMNSGQICLNVKRIYVHESIYEKFRDAIVKHVKNYKLGDGSSEGTSHGPVQNEMQYNRVKTFFDDIEKQGWKVATGGKFDPAPKDGYYIQPTVIDNPPENSRIVVEEPFGPILPILSWKNEDEVIERANDTKLGLGASVWSANIETAERVAKQLEAGTVWVNNHFDITPMAPFGGHKQSGIGAEWGINGLKGFCNVQSLFVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDZ7</accession>
    <name>S0EDZ7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432707.1">
        <property type="nucleotide sequence ID" value="XM_023579962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDZ7"/>
    <dbReference type="GeneID" id="35400093"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06616"/>
    <dbReference type="HOGENOM" id="CLU_966860_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="281" mass="30678" checksum="A742A7F906CA166C" modified="2013-09-18" version="1">MAFSSVHAALEPYVDIPFNASLSGILFLAYRCLISKPGLLLIIVYTTSAIIVLFDRTSTRKEMAKTMAELPLGLGSVLWFIVSGRSTKVQWLHAFTIYVNFAVYGNILMMVATPSGGTFRGIGCKVACISLSAWIVLQGYQVQWETIMLHDDLFVFTAASKSWIFAHAAYRFILLTLPCFGSGRRHRLMEVYSLGLTYLLSWSTGLPFEYCFGMADTIVAPAVTAWSSISKTFNLITRDAGNGQPSANGISDTGDVYLGIVALAVAAYAGLNMLSLGRLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE76</accession>
    <name>S0EE76_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to vesicular transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_05584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432787.1">
        <property type="nucleotide sequence ID" value="XM_023578811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EE76"/>
    <dbReference type="STRING" id="1279085.S0EE76"/>
    <dbReference type="GeneID" id="35399063"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05584"/>
    <dbReference type="HOGENOM" id="CLU_002906_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="965"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1058"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="965"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1058"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT70708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1131" mass="127063" checksum="CCF1C3BCBC4E049F" modified="2013-09-18" version="1">MFQRFKSAIDRTIAEEQARSQTAAQSRSPSRTRSTSSRKGDGTPAQRAKARKQAADAGDAPNPDPAVFEAAFVIDDESEPSRATTPMPPTAKDDSKTDNGDTQNNGSDEKNADGSKDEANSGKNQDGGDGASAAKSEATKSQELSPEIRQKLRKLEKLEATYPELLRSYRVAHRRATAIEPFEKALRENTPLTSISDPEALVEYLNQLNLRSDMVMQELKKVSTDKEELQKKHNETKERAKKLEEELAALKSGDSTQPKTDESEATKDDKHEDTPPDIPEKSKSPVSSVIGMFSPKHKPQKSLSEVTESITESKAKSEEFFSYDDEIPHLQADLTSKSEEIDKLKSEVESLQKELTTVKENSAGLVENLENATRELSESRDAAAAKESLQTQLDERNKEIESLNQRLEEAQKQLKQLEEDKSTHTAKVDELEVSLASSDKRASELDAELAKASNAKNISKKLIDDLNNQIELLKKEKTESQTKIDDLTKKLESKPAPVAPTPAATPAPTASQPVAAAGGGNKKKNKKKKGKGGAGGAAAPAVEAAVETPEPATPAEPEGNAELEAEIAKLKEEVAEKDTQIERLSKRRKTEEDLREEIESLQENLLTIGQDHVEAKEKIKELEAEKLELKTQIADLEKKIDSSASDAEVSTKLQSEMESLKTEYDELKEKTTTLQADLGAAQQLAQNRFKDLTDLREVLQKAQPELKSLRQESATLKTTKEELAAKTKELKDMEKREKDLKRDVERVQKLASDRETEIKGLLEKLATETNAKLRLEDAQRVSGRDLRRSEAEKVEISAKAEKTEAELKTVQEELSKLRPKVKELEEQMHKLKREKTAAQEEAEFKTQQYSNAQGLLSSMRDQTAEMSVQLKESKSQAESLEEELAEVQRLLQERTREGETMRRLLADVDERADNKVREMRARMEAAVEERDRIEDESSTLARRKTRETEDLKLKLKDLEREVKTLTHERDELEQREKEWRRRREELESVEEKAEAEADELRTTASQLRTALDASEKQVRDVEKQRAELRRMLEEARQRYEKVSKDLKSVQTRLVANSSRSSFDSVRSGSNGSPAAGGTPDTVYLKTILLQFLEQKDTKLRAQLVPVLGKLLRFDKTDEQKWQKAVQHIEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE98</accession>
    <name>S0EE98_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_12670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435197.1">
        <property type="nucleotide sequence ID" value="XM_023582303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EE98"/>
    <dbReference type="STRING" id="1279085.S0EE98"/>
    <dbReference type="GeneID" id="35406126"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12670"/>
    <dbReference type="HOGENOM" id="CLU_004804_2_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT73119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="682" mass="75823" checksum="046A8C5DFE905A8F" modified="2013-09-18" version="1">MSATAAAPRAMSQSVTARRKMRKGTHSCSECRRRKIKCKFHPGTASPCIPCAARGSRCLDQRNATPVNESNINTESVSLRERVAVLEKMVRNHAVRHEPTLGHEEFDIEDELVEADERAPFVSMLNKAEVCWKLILDYDGPLIVSEALEESHFQITQPIQETPSRTGPPFYTQSSSEACLKLRSALPEYDLLISTLSQNGAWWSSFRQKVQVICQGTYQDLAAFAARAYTSSDPAELGMLVVAYARSTGNKHNLYGLVDRLAIPDSALSYSAEAMELLLLLAKAYSDIGQPRQSWMMYRKGLAISEVMTRNCFPSSEEYLVGFYHGDRFSSLLLGIPYGFNDAHLGPSVEPYNVPTYPEQRFVLRCASIAGKIIDRNMMPGKPSSASSMLLDEQMDTIASSMPLSWWDLPESLPNCHAETDELRNVLLLHFYFFHVRINLHLPFIVGTEMTSARSSHRLACLEASRQLLKRFTLLRTEIQGFSIFDCKTSDFVGFMACVSLILCLSQPRSDEITVPVPDEDQDLIAQVKSIFEREEKAGCKVACQCRRMLNILSGITLVSDESASSQLPDRIAIPHFGYVRRDVVQQAGLQATAGASVVRSTTQRMTAAPVVSSDGLGGLGTGSGSCNWSETVDTGICWEFGELEHFQIDDDLSSWLDTAMLDVNLEWDMPLSGFFPHNPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEI2</accession>
    <name>S0EEI2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to NIT3 Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434350.1">
        <property type="nucleotide sequence ID" value="XM_023581692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEI2"/>
    <dbReference type="STRING" id="1279085.S0EEI2"/>
    <dbReference type="GeneID" id="35405579"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12123"/>
    <dbReference type="HOGENOM" id="CLU_030130_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="318" mass="34983" checksum="EFA88C9A3F2C212E" modified="2013-09-18" version="1">MAVTIPSPSFKVALVQMKPKPLDAEHNFAHAAEQIRIAADQGAALAVLPEYHLTGWVPEEPSFALSPADAGKYRKKYQDLAAELHINICAGTFVSQAPQSDDQQNADARPTLLNTSDFIDHNGNLLGTYTKTNLWIPERHTLTSFVDHAKNISKDDYTAPNPHQVIDTPLGRVGILVCWDLAFPEAFRQLVLAGAKIIIIPSYWTALDMCKDGLAYNADCERMFIQSALVTRAFENTAAVIYCNAGGPAGEGFFGCSQVALPIVGTVPGSFTDGEEAMRILDVDMKTVDIAERNYQIRQDLARDDWHYGYLKNTVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEI3</accession>
    <name>S0EEI3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435454.1">
        <property type="nucleotide sequence ID" value="XM_023568105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEI3"/>
    <dbReference type="GeneID" id="35403404"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09937"/>
    <dbReference type="HOGENOM" id="CLU_1525276_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="176" mass="19963" checksum="F7FB16633ECDD863" modified="2013-09-18" version="1">MERIPYLRCSRRGTPTGWTVHCIVRVQKLLSRDKPMEGPRDLDHSIQSYAKAFNTTLYCNPSFMASSEQFLVCASNGSINPNDPIPRLSCIGPAPSSPHALKEVIRGGIHLPPELLDINAALRRERAHDIDLEKSRRHRAKRRAEDPIGYKQRFTPDKKSWSLKNPDKVLKIATKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEM6</accession>
    <name>S0EEM6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to STB5-SIN3 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_09127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432932.1">
        <property type="nucleotide sequence ID" value="XM_023580096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEM6"/>
    <dbReference type="GeneID" id="35402601"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09127"/>
    <dbReference type="HOGENOM" id="CLU_420395_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT70853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="653" mass="73083" checksum="A1415756D93C0F27" modified="2013-09-18" version="1">MSATDDGELPAVFESASAYDTHSDRDTDRIRSPRRGLKRISAACQRCRRRKQKCDGRHPVCGACAAANVPCVPSDRLVVKVDRECECDHLRGQVERLKDRVNELQTQLAMQSRLPSEARSQESHLQIRSVADRQEPDGSVASLERGYVGRMLLPTFRGLGPNGASETGFMTGPWQLWHGLSASETPPTATSNTFSLHRDGLSLIEVFFDRRWPQYPVLHRPSFMEQHYIPYCNGQVRSRLSAFEVHMVLAIGASEKARISSDAPVSHEVFFEAAVRDLDAVLSADDLDCIRCLSLLCLFGSNEPQSVNLWYTVGMALRLAVGIDMHREESMANKTLLDAEMRKRLFWSLYTMDRSVSISLGRPLGIQDADITVPLPLVLTDEQIAGPADQAIANILPDVRDMSAFRHIVELRQINAGIYSALHSAGGINLQGRNLDSIRQQHYTRLNAWLLSAPRYLAPLSMYQTPEWFQIAYHQAVINLHRPSHASPVSSADAIRLCADSSISLISCYNALYAKNKIIYTFVALDSLFMAAVTMLYSIRASSVVRLELTREVVEANIETCVRLLSKISHGKKVGERSTQIIRRLGNATLAIFDNTSHAEGEIDTEFMSWFGVKSQNPPPRQEYPTPSIDTAWNDLFEHGYDLNSFQNVHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF56</accession>
    <name>S0EF56_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_09604</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435669.1">
        <property type="nucleotide sequence ID" value="XM_023568475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF56"/>
    <dbReference type="STRING" id="1279085.S0EF56"/>
    <dbReference type="GeneID" id="35403072"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09604"/>
    <dbReference type="HOGENOM" id="CLU_028200_25_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="44"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT73591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="381" mass="42629" checksum="BADD5848A324E29C" modified="2013-09-18" version="1">MRNPPPEVVASWPPPNYVNPVHRGPTLLIVEVTIMSVAILTLMARLYVRIFKVNKHGLDDWLMLAAMVFGIGVTVCVILAAQLYGWNIHVWDLKKSQAENGRKVSLAAQTLFLFSSGLAKNSILVSYLRIAPAKSWLRRLTYASLILVTSLIFIFLIVLWTQCNPTSAYWKLDGGDSCRPEGPSVLSQAITTVITDLLVCALPLQTLFHLKLPFSQRMALIVVFSLGLIVVFAASMRAYYTHYVTDETYDVTWQGFHLWIWTAVEANLGVICGSIPALRPLFRNMFRSKSSSYYNKTNSHAYPPGTAPGVVTVVTSPKKNSRNWTDSLQRNSKGVRIQDDHIDVEGGYNDARRQKSSDSGASSLEMDTWPPRPQPRSWPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFB8</accession>
    <name>S0EFB8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Related to integral membrane protein PTH11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_12410</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434610.1">
        <property type="nucleotide sequence ID" value="XM_023582013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFB8"/>
    <dbReference type="STRING" id="1279085.S0EFB8"/>
    <dbReference type="GeneID" id="35405866"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12410"/>
    <dbReference type="HOGENOM" id="CLU_028200_6_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495874" evidence="16">
        <location>
            <begin position="21"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="18">
        <location>
            <begin position="106"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="364"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT72532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="440" mass="49256" checksum="16CA7EDD44E7FB6B" modified="2013-09-18" version="1">MRLLRGAVFACLAALPLAFAQQESSSSAAASALSALPEYQKCMCTNTALQQDIEGCVMRACTIPQSLVTKNATLTACGAPVRDHSPQFIVLNEVMAIITGIFIIQRFGTKLYWKLPLGLDDLFIALTMCVAIPSIVINSRGLAPNGMGRDIWTVTPDQITHFGMFFYTMAILYFSLQTFLKLSMLFFYLRIFPTQNVRRLLWGTVAFTVVFGLVFIFVAIFQCRPINYFWLKWDGQHEGKCADINAVTWSNAAINIALDFWILGIPLSQLKSLNLDWRKKIGVGMMFSVGIFVTIMSILRLHATVQAGVKTTNATWEYLAVSKWSTIEGNVGIICACMPSLRILLVRLFPKILGTSQRYYNYGSKSNKQTPGNTHNRSIPLGTNATSQADRSQRRVDPVGIECHRTYEVEYGDNDETYLVHMKDMDHKSARSEVRSETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFC3</accession>
    <name>S0EFC3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435769.1">
        <property type="nucleotide sequence ID" value="XM_023568597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFC3"/>
    <dbReference type="GeneID" id="35402962"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09494"/>
    <dbReference type="HOGENOM" id="CLU_2573952_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485563" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9040" checksum="2615AA47142EB010" modified="2013-09-18" version="1">MKFITSLILLAAAYVSAKPSGTAECAAIYQRCIETITPQECKKTDRDCLCKAWDDVITCLVDCPNTPRYWLAKENARGFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFX4</accession>
    <name>S0EFX4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to nucleoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433367.1">
        <property type="nucleotide sequence ID" value="XM_023580621.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EFX4"/>
    <dbReference type="GeneID" id="35402129"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08653"/>
    <dbReference type="HOGENOM" id="CLU_002778_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1662" mass="185947" checksum="A17AB9191EFD9F3A" modified="2013-09-18" version="1">MAEITALDALQAFHQGLLSLREGRVEGAEALGNEFLVQVFETELGKLWDKPARKGDNRNAVKSGKVVIDGDKYSINDNFQQDVLTFSDEVELDELESTRCLLESQEDPDTLGRSLLECAIIRFHQQRKYVLDIVRLLLELEGLDDDLADTEALESVKLYVAERLLQPSMGADATKRIVPRCMASMKEIKAWLQKIGDKIAAAQTLGQTTTGGISEQMETIEFSRVSLMQQHELLGVILCRSIEMRQGSTQDFLDFVSVLQKVDRYDALLVHLIPSIGAYISVFGSAEGGYDLIKARELNGKLFPADSPLWPLSQLQAAFRAWWLAEYSGFYVDDPPEAAIPPNTDLDEEDRQRSKAFLESLKDGSFDFLLSIAADVKSPDWHDPVRAGMRKWLQRKSPALAPDAIPFADFFQLTLMLQLEVFVDGFISNLPDVLRKLRVEEDEQRQSSQTHEQDLDLERFLLVIAYAYEGRPDAAMNFWSDPDSNLAGFMHWASRRASTPLVTAFCEMLQAISENEECASAAHEFLMDEGHHSSGKMRKSQSLTWAQIFRELDFFSAKIRQKPTPPQTIRYRNEKMSSDQAETEPESAMMLECYLRLISKLASESEITRQFLLHNPNYSLVETLYELASSPIPPRLRGCTFMALRALMARKSLQEGILMWNCLDTWITGGYASHPITRQAQQSPIVSMDRIFDEISSGFEDPESFIQLLLSLISPAIDSSPLNDGLPFPENLGSASRMPGIEVYVDFVMGLVFATKANDLQDVNQTRVLRLSCLEFILVCLNTFNEDLIIMANETNINVDGVIATTDLATYVRMHPFARVMEWMFNDKVMAALFNTIHQEPVDVGNAAPDSPLILGILRAVEVISKVLDLQATYLELVRPIIKLQSNQRRPPVSNAAFASFEDGLVTRLNLVVDLGNYCGIGHPDLTLACLKLLEKMSSSSKITAVWSGSNRQMHRNKAIVALEANGEHEAISRSFVSELITPLEIGREADSPAYVTKIYILDFLYQCLQETPRKPTIAHLLLGFKCGIDSLSVDVKGAFASRTSLFHTLLRLLLEAPSGDAQGMRQWLIAIKSRVMRILHILWSSPLSAPVVVEELRENEILFHLLLRETVINPDLSWEGENVAMVQFPVTDGAVALIDFLSLRSMGLEYIAMELCSIAQNRMPSVKRRIFEALNGQIIGEGNTPIPIPTIFDLYDFLLPEGVWEIPLPPLQYYKNIDLSACLENDADSNPIYNLERVKEVLLLKRGEAQGSGALVAAQDLAAIEREEGMIIEYLISSNRQKQLTTQSLKVLKTWTKLLLVMIESNDFKGSAQTSFFLQALQSILPSLEAFASERPDEAFELARLAKVLLFKLDLSASADDKQGSAIGNLVSDKLFQLFQICLQAIGKWAGTPELRSVYYGICYRYLTGMADQGSLISNRPKTIKTIQVYGERLINVICDDAYGGEAQCQTAALILLNALVSLGRQESDDHVVETLNRLNFIGVMVDSLRNIMQEWHEVFTSGTSEQQNYQNARLALLLELAQTRSGAKYIIHSNLFRSLEDSGLFGADPELQINNTNPRALEQHYGLLAQVVRIIGAALVSRGSHNVVQGRKFLTEHRMLVTHTLKRSAGIGSGNADEGLDQNIEELAEGLMVIIAATRFLEFENEVLPEPKQQSHGLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGJ5</accession>
    <name>S0EGJ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433582.1">
        <property type="nucleotide sequence ID" value="XM_023580886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGJ5"/>
    <dbReference type="STRING" id="1279085.S0EGJ5"/>
    <dbReference type="GeneID" id="35401892"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08416"/>
    <dbReference type="HOGENOM" id="CLU_060140_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="374" mass="41018" checksum="47CF95DFA39DA510" modified="2013-09-18" version="1">MSSLSIDCSQWTELNDFSEYIQDLDSKTQFNKSLLEYCKSEICNAIYGTGNPDISGIGVAVGYVLEIILSILLSLAVIMSKRSGKNSHGREVAKAGLEAFVDCAAYFALALQLATIAVLARKDYGISTADLGAIEARISQSVAVVSMMPLLYPVALLEPAAKSSARASIKHNARLLLLSVTVALSFYPFLSRCIHAFNISPIGEGKGSEVSPTDWSVVEDMCFPAEYRNIGRSTTFKSLNGLELTASLITYIFTFWLLAGLPGTCYDHDEKAKVTKGAEDKASWRESVNKWFSDRPLAAVLPLLVLVGLTIPLLVVIFTLRNVQEQMSENMGEKYDGNYWGFGQIVSIILFIPVGVEMAYRLRFSSVHAYKLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGN1</accession>
    <name>S0EGN1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435893.1">
        <property type="nucleotide sequence ID" value="XM_023568743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGN1"/>
    <dbReference type="GeneID" id="35402832"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09363"/>
    <dbReference type="HOGENOM" id="CLU_038488_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="497" mass="56214" checksum="E6EDE3E0E202237D" modified="2013-09-18" version="1">MDSPHMDEKNTTLTEQERKKLRNRLSQRAFRRRQAECIRELKNRVNADQRSDSERVEALQKENRLLRKQLIDVQTKMSRMMASVQLLSDSVAKTLDDTASGEGDERQRDERQRDGPERVNGKTESDEHIAEESALQSIDLEAFDPSILDFDAPFSSSSVTASTDNGISSELINVSGTSPFYSQIPNIWSHEYQMGMQPYLTAINATAESSLVLGKDYSFTNSPFSDHIQLLQRMLKNKLNTLGFVPEGHNPVQSVYQPVLMVLSMFNSMTRPDVMAWYAKTRFYHIIELTAWQLYPSSATFNKLHPRYRPTTAQLENPHPGIIDWIPFPTIRDRLIQLHSANPHIDQIFCDAVTGYVVEALMSDLVLGAPQITVYVRVTDLINTMSSATSESENTIAMLPAPDISTLFSSPAYARAAFNKLNMDKGAGYYKIDPAFFEKYPELWDQASDVTATGMPLKPKYQKILTYPKPLDSSTVETYRSFIDFSLDAANTISMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHC3</accession>
    <name>S0EHC3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to G protein coupled receptor like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436252.1">
        <property type="nucleotide sequence ID" value="XM_023568972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHC3"/>
    <dbReference type="STRING" id="1279085.S0EHC3"/>
    <dbReference type="GeneID" id="35403681"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10216"/>
    <dbReference type="HOGENOM" id="CLU_024810_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="405" mass="44876" checksum="1097ACE9CB8DFCBB" modified="2013-09-18" version="1">MVTAPAASAISAIERTCSVPSLLGSLFIIATFCSSKLFHKPISRMLFYASFGNMMSNVATLMSKSFLDQPDSVGFMFADVFWALAMATNVYLTFYHRFDGVRLRKLEPLHIGLCYGIPFIIGITFIFVRNKDGHRAYGNANLWCWLTVEWDAWQLATYGLIWLIIFIAFTIYVRTGITIYKWKKRLNSFSNSYERNISSQVPQNANPMVIAKTTKITISTSDSAPTGFDQAFGTATRPEPVHSANIYTGPAQPIANSSDQSYIRSQQSDRKGRSPSDDAAMSYAKTALLFFTAMLITWIPASANRLYVLVDGKSSVSLGYLSAFVLPLQGFWNALIYYYTSRAACKQVIASLRTGCRPLEESDANGSSFADGNNEQGFQLEQVKTAKRGQSFGDTESTTSLTAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHN4</accession>
    <name>S0EHN4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436223.1">
        <property type="nucleotide sequence ID" value="XM_023568299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHN4"/>
    <dbReference type="GeneID" id="35403230"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09763"/>
    <dbReference type="HOGENOM" id="CLU_1349029_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="203" mass="23606" checksum="38CF1304F2E7D2A1" modified="2013-09-18" version="1">MYVSSRDSGTRAFRQLKAREFHEMQWNENMIHKGRLVGEKSIDLGEPPKSRATEKHQAQTERTHHRRSLSSKIIRSEKMNQIIHIFRVTDKGNGKNENQKPALIQDDHSTILAHDAFKQQFDAYVRDCEIPNANFARKFGLFTSDRSLPPFIRELPVAEDKAMDMVTASSTKGVSNSRRFHGPFTPQLWFDSGIDYRWKHRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EID0</accession>
    <name>S0EID0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435670.1">
        <property type="nucleotide sequence ID" value="XM_023568476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EID0"/>
    <dbReference type="STRING" id="1279085.S0EID0"/>
    <dbReference type="GeneID" id="35403071"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09603"/>
    <dbReference type="HOGENOM" id="CLU_039475_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF263">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="115"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29793" checksum="23B44BF1AADD074F" modified="2013-09-18" version="1">MSQPDPKRVKTDDEAPYELIYWPVIPGRGEFVRLVFEEAGVPYSDVAQNIEKGMNAVKSLTSTDNIGDEHNPPALAPPALKHGDLLISQTPNILLYVAPRVGLAPKEGNGVYHLNEIVLTILDGLVNELHDTHHPIAISLYYEDQKEESKKKSEYFIKERLPKYFKYMQRVLDAKTSGEGPWLYGDSLTYADLVLFQAVDGTKFAFPKSTEALKKSGEYDGVFKLYDAVKERPNISKYLQSDRRRKYSEGIWRYYPELEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIU0</accession>
    <name>S0EIU0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436772.1">
        <property type="nucleotide sequence ID" value="XM_023569576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIU0"/>
    <dbReference type="STRING" id="1279085.S0EIU0"/>
    <dbReference type="GeneID" id="35404220"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10756"/>
    <dbReference type="HOGENOM" id="CLU_061199_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF8">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33190" checksum="79513BFB342231D5" modified="2013-09-18" version="1">MPSLNSWWWRFLENYVYAVPEPLPRKRTKPMEVLCVGLPRSATESLQTALLKLGYDHTYHGWDIVYETPNYSSKWVRLCRKKWFGSLDGNTTITRDEFDEILGHSVAVTDAAASVFAAELIAAYPDAKVVLNYRKDLDAWHESAVKTLVSVNENWALYLLSCLGKLPFWGWHVYERFMWPGLFRALDGNIETGIARNGKWVYKEHCNMIRGLVPKEKLLEWNVEDGWEPLCKFLDKTVPDEPFPHVNKASGWENHEAEVTKRYLTSALSGVAVVSAVGIATSAIAYKTMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJH5</accession>
    <name>S0EJH5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434601.1">
        <property type="nucleotide sequence ID" value="XM_023582001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJH5"/>
    <dbReference type="STRING" id="1279085.S0EJH5"/>
    <dbReference type="GeneID" id="35405856"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12400"/>
    <dbReference type="HOGENOM" id="CLU_028481_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="188"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="426" mass="48380" checksum="1D3B573227DF583F" modified="2013-09-18" version="1">MSRNLLPFLYQTRTLQLACRRPASIIFTQRAGVATSTRRLRKADNSEIPFEFDDEDTTSANETEIERQGTLTPTETEIFKGIFDDIAQGRLGKNKKPSQFGQTQPTISASNQERPDGARRGNTLVEKAHNSNFSGDFLKRYPSSLRRAAENALGKFELAPKRPNLYSLAELDQAEKKQMREWAKYEQIREKEKTRVQNLMKASKTDIELWNVMEEEVFSLPGKLGIVEKDTTVKRGRKSKEQIAREEAEKVKAEKAEKTEGEKAVMDIHGHLYPQYLVYGLELFDAAFARSSILAFNILPRVKELGLSSYVLGVSTTFFIKLAEIHWKRYGDATSAFDALDEMKPVGLFPNEELGDLEGLVEQISDHLHSCTWGAQGPFVMAMMQAPPYDASLMNRLGRMKGLIAKKHFYNERDGRLEDGTDRVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJP8</accession>
    <name>S0EJP8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434676.1">
        <property type="nucleotide sequence ID" value="XM_023582090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJP8"/>
    <dbReference type="STRING" id="1279085.S0EJP8"/>
    <dbReference type="GeneID" id="35405935"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12479"/>
    <dbReference type="HOGENOM" id="CLU_038300_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF44">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="471" mass="52580" checksum="E35EE07B4286DE3D" modified="2013-09-18" version="1">MSSRSRRGCWTCKRRHKKCDEKRPVCERCVQAGKTCEGYKTRLTWGSSDTASSAGGGIVLKPVRPPRQKGNSLRDSRMCPVVESVVDELVDLPDFPSIQSPDDLDLLCLQFESFSEGLPDEEVSQKLMDSFTTIGYQTITGRAGHDTMFKSDILPLCEESISLKHACLAYQASLDIDTSHLTPLYMQSALSNYLNDLENPSMLRQDVTLATGVLLCSVSINSLYIWSPLLKGLHGVLQARELLDDPQRPPVANHLLEAVGLLDIPFFTLNRITPSLEIWKSYVQPHKHSGIEQTSGIPYSLMNLLANMDSTTIEQDLLQWPGELGDEFAQIHLWEAFRLAGILHSRCLADHQQDQTMPPRANVSTEILRMKVFASIQAIIGIGTFNFRLSLARAILYPLFIAGILAENAQEQQLTRVAFQYIMQKGQEGTEQIIMDIVAKVWKNGKDGNEASKLMIATEATAELNAEIHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJQ3</accession>
    <name>S0EJQ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to PET8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_09817</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436145.1">
        <property type="nucleotide sequence ID" value="XM_023568238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJQ3"/>
    <dbReference type="STRING" id="1279085.S0EJQ3"/>
    <dbReference type="GeneID" id="35403284"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09817"/>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="91"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="192"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT74067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="280" mass="29624" checksum="C9AA056F56B26BA5" modified="2013-09-18" version="1">MSANPPTFQSALLAGALAGTTVDLSLFPLDTLKTRLQSSAGFFPSGGFSGIYRGIGSALVGSAPGAAFFFCTYEGVKGFLADKDNTSAPGWKAPLTHMAAASAGEVAACAVRVPTEVVKQRAQAGHHGGSSAAALRAILSRYSSHGFVPMWRELYRGWGITVFREVPFTVIQFPLWEAMKSWGRRRRGGREVTGAESALYGSMAGGLSAALTTPLDVLKTRVMLSKESVSVSEIFGRISREEGSRAFFAGVAPRVTWISIGGAIFLGSYQWAINTMNGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK09</accession>
    <name>S0EK09_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436290.1">
        <property type="nucleotide sequence ID" value="XM_023569016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK09"/>
    <dbReference type="GeneID" id="35403719"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10254"/>
    <dbReference type="HOGENOM" id="CLU_023132_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="439" mass="46571" checksum="58FED95C57345373" modified="2013-09-18" version="1">MASTSQNSVFEAVPAAQSTGDMDKKIPASPTVFAPDGSTSSVRRGSIEQPYRTYKIRWYGLVVLTLLNVMVSWSWLTFAPVTSSTAEFYGTDETMVNWLSSIFVFANFAMTLITIKLLDWGLRPTLISGSALLLIGNWVRYAGSYSSDGNKVSVVAVAQALLGMSQSLVLSAPTRFSETWFTSQGRVTATAVMSLANPTGAAIGSIVVPLWTNEPSDISAVVLYVAIISSAVAIPGFFIPGTPPTPPSAINHAERPKVLPSLRILGFSDTEAGIGGGLLIVLGLIFSAITAPIIDRTKKFILVIKCGVVVGGLCYLALVWVPSTKKIGALYAVLCCIGISSLAIVPVVLEILTEFSYPAGAEITSTTAWAGGQLLGGCFIILGNGMKAAESADPPRNMKDFTVFQAVLAMAMIPLPLMLGMFGRSDQVALKRTNVHQNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKQ8</accession>
    <name>S0EKQ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to secretory lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437268.1">
        <property type="nucleotide sequence ID" value="XM_023570107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKQ8"/>
    <dbReference type="STRING" id="1279085.S0EKQ8"/>
    <dbReference type="GeneID" id="35404695"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11232"/>
    <dbReference type="HOGENOM" id="CLU_029538_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004486007" evidence="1">
        <location>
            <begin position="21"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="154"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="494" mass="53506" checksum="F159694428E9E78C" modified="2013-09-18" version="1">MKYSPWSLFLSASLLGGTEAQNLALALPFSTGFNSSFSLSPAQIKGANLSDTVASSVNTVINFHQSSLANGGPKQDDFYTLPVKRTDLRPGQVLKVQEVTEPAPFSIAPGSSLSRILYTTRNFNGTIIPASAYILWPFLPRQFNSKSDDKAPAILWAHGTSGFFIDSAPSTHRGLYYENVVPLALAQEGYAVVAPDYAGLGVDKSWDGSDIPHQYFATPAGAQDTLFAMEAALEVFSNRLSGKFAIMGHSQGGGVAWGAAEALAKGKDISGRRAFVELLKGYVGTISIAPVTKPLSTPRLFSSYSASIALSSIFPDFKPSQWLTPLGVARQKLMKQIGGSVAAGQQLFFTESQSVFEKHDWYNSSYHAAAFDKLGIVGDKPFAGPLLVIQGSEDVFIAATTTNETITDTTNLYPNGSLSYIYVEKFGHTPIISGVRSLWMAWLEDRFQGKKQQRGLERTYVKGWLGDDKPFFGSNGYLQWSGAPEYTYQNPGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL26</accession>
    <name>S0EL26_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ILV1-Anabolic serine and threonine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_11360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437388.1">
        <property type="nucleotide sequence ID" value="XM_023570249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL26"/>
    <dbReference type="STRING" id="1279085.S0EL26"/>
    <dbReference type="GeneID" id="35404822"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11360"/>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF6">
        <property type="entry name" value="L-THREONINE DEHYDRATASE CATABOLIC TDCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="4">
        <location>
            <begin position="24"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT75342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="335" mass="37138" checksum="7D64D58CB80C63D4" modified="2013-09-18" version="1">MPATPEIFDIGQEALRQWRLNKLYVHRTPLIPSKVKNIKYGSKLWLKLDHIQFTGSYHFRGAIARMKDNPTKKPFVTASTGNHAMGAALAAHALGTKVTIVMPMGVERHLLDKVMQYGPKIIQRGHDLNEARAYAKDLAEMSEHIYFSPCDDVMVLAGLGTVCVEVLQQFEFYQKDIHNIFAPMSDIALISAIGCFATDAKRQAGELRPKVKVWGVTALNSMTLAGSLSAGFPIETENSPTIAASEFENDVIRHGIDFRSARATVNHVVTCTEAEILVALRQLHLQERQYVDGFSALALAGFHKVADKVKHEISTVILCSGNYDRDKMAKLVYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL31</accession>
    <name>S0EL31_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to sulfonate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437393.1">
        <property type="nucleotide sequence ID" value="XM_023570256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL31"/>
    <dbReference type="STRING" id="1279085.S0EL31"/>
    <dbReference type="GeneID" id="35404828"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11366"/>
    <dbReference type="HOGENOM" id="CLU_036005_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000008">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF9">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_3G01010)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="86"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="385" mass="43700" checksum="65B6286FA58B9897" modified="2013-09-18" version="1">MVPAPIDPSIKDVAEPIKDTLKIPDPAKQRLEKSGVDLSKGYPYRPSRPLYLDDVYKIRDKPRDHIDAGARADKSKKSLLSAATKVTDLTAYIGTEIEGLQLKDLTNQQRDELALLIAERSVVFFRDQDLSPQQQKELGEWYGEVEIHPQVPHVPGVPGVSVLWPDLMAQERPASFRQPGGASRWHTDLVHEKQPAGITHLHNDTIPSVGGDTLWASGYAAYEKLSPEFRKIIDGREAVYRSAHPYLDRDHPEQGPKYIERIHPIVRVHPATGWKALWVNRAMTDRIVGLDRAESDVILNYLYDVYEQNVDIQVRFKWTPRTSALWDNRITIHNASWDYSGREPRHGTRVTSLAEKPYFDASAPTRREALGLLGDSEKKELEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELD6</accession>
    <name>S0ELD6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_10780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436795.1">
        <property type="nucleotide sequence ID" value="XM_023569602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELD6"/>
    <dbReference type="STRING" id="1279085.S0ELD6"/>
    <dbReference type="GeneID" id="35404244"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10780"/>
    <dbReference type="HOGENOM" id="CLU_003918_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="10">
        <location>
            <begin position="644"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="8">
        <location>
            <begin position="780"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT74717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1002" mass="111479" checksum="89D0C60CF34AF24E" modified="2013-09-18" version="1">MRLKRSKTKEESSMGDDEASFHAFNSPKRLPAWLDHFNAKDLKILFKCSLAVWILTLFIYISDTLRVLGQSAFFGCVVLFIMPPSGVVFIHFAAGVMICVGLALGWAWGVITMKAALATRPLADLQQRYAELQQSMPQNTTNVDQASGQATYQQIAIYEGFMLDTRVSVTYFCMMGLFVYLMARLRVSAPNLMLVSMFSMIVADIYFTTAPLIPTFNGTIPKVLILPSAIAVGVGVVCNLLFFPQSTSQITLGSMADLLRPMNGYVKALTWHFKTRARFEPEQLQALKSTLTVSFKSVESAVKFLPLDFSYRRWSPEDIKSFQEPLRQVLVSFGELLQMSISREELFAKDEALTKAAEELEKSDNEKHPLAYHIAKAADLRELTRHPDTEEMIVKAIDALSLCATPLLQTLEQSVNAIIEAFSGASQNDTISQHEQILASLQEALEDFEDTAAEQLIAPHAHLFDANGKVIYNDHRAPPLLGLMSGLLYQERLINLTKNIGGVLERAIEVERVRTSKRVWLPKGLQHIFSLGLSQDAPPSTIPNSNDLTRTMSVISKPEKKRGLFSKKRKEKEDPEGARTTATILESMEQPTSRRRSKSSLVFLALINFFTGVEGLHALRALVLTIALAVPAVIPSSAGFYYREKGLWALIMAQMALEPYMSDFTSGILIRTLGTVAGGILGLLCWYIGSGNGPGNPYGLAAIMAVAVIGMMWWRLFAPPQHMAAGIMLTSTMYMVMSYSWVDTHIPSYGNPGVGYEVFWRRILLVLIGFGAAVLVALLPRPLSGNRHYRQILSSQLSSIRDRYALLISVWRSPPDDFVEVIEKQATTTEELLNSIALPILKTKFEFSTSNIDTETLSRANHLCNNLNVFLAQFSMTATKLPLPVRERFFYRVSAGDENLIADLMSTMTLLQHSLMSGEPLPAILPTPLVGRAIQFRRLRGDFQDEGNSKEYLAKQEGRQWSAAVYSFVRFLGTLDELVIVVKKSVGERSHINAEALGGSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELE1</accession>
    <name>S0ELE1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to tetracycline resistance proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437488.1">
        <property type="nucleotide sequence ID" value="XM_023570365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELE1"/>
    <dbReference type="GeneID" id="35404925"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11463"/>
    <dbReference type="HOGENOM" id="CLU_066482_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="27"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="346" mass="39054" checksum="B04A990949525CD7" modified="2013-09-18" version="1">MAEPSLGAAPKQDLQSTSTAKATSPTFHEFRRLPPELRLKIWKEACLSRSTSEKGLHYVTVDIVDTTGQWKESNVDPVTSDPNIEGQNYDYEGSAYATLRALECPWEKTGSSQPPANPPNKSAYLWDAGLWSACKESREVIEKHLNVKEWLAHRGQGRPRGQPAWYNEAFPSAIVPKTKNDNWCPLVKPYGDIFCIDTYNLDAVPDSFLEMMLLAPCLGTKTFTVVGAWNIGFKFEQSWMNNFPNKWSDLGAVGARPSLWIIDDNVRWVARSHQRCSTVWRDLEDEYVAIGWNDTRSNLVDGTQGAVADFMTALEQLADREDYLSDSLLLSIRLLVRKDNMLPGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELT5</accession>
    <name>S0ELT5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_11824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437832.1">
        <property type="nucleotide sequence ID" value="XM_023570767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELT5"/>
    <dbReference type="STRING" id="1279085.S0ELT5"/>
    <dbReference type="GeneID" id="35405285"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11824"/>
    <dbReference type="HOGENOM" id="CLU_012494_13_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="109"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT75786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="366" mass="40799" checksum="2E02CF16EF80BAFD" modified="2013-09-18" version="1">MATQTVNPPAVDGYHDSEDDFSSDDQEFHVDERSGRSWPTKILHNVIQPIKPKLVDIGKVSSADPTRCKPSRRARKRCDVQENKVEGIWTYDMTPKSSDGEKKSYARRILYFAGGGWQAPPSGQHWTFCAEMTNRLQDTRLTLVSYPLAPKDPVQDAFPAICKAYNVLLKESSDLGERVIVAGDSSGGNIALCLVTWTMRDQDVHVVRPPSAILAITATTDLRHNHPDIKEVDKVDPILSESSINDTAGAWAPGHSDVNQQNGTITETTDRNEKLNWSADDPRVSPIHADLGVCVRNNVKIHGITASHDVLGPEAVDFRERCRKEGVDGQWLSWGDQMHCFPLAYKYGLKESKEGLEWIIDVLKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELW0</accession>
    <name>S0ELW0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to DUF1446 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436970.1">
        <property type="nucleotide sequence ID" value="XM_023569808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELW0"/>
    <dbReference type="GeneID" id="35404428"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10964"/>
    <dbReference type="HOGENOM" id="CLU_012617_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="503"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="613" mass="68174" checksum="EA03547BA5629F6C" modified="2013-09-18" version="1">MGSQINRRPVRVASASGAITDMVENLAELAKNADVDFIVGDWLSEYNMAARGMLKAQRAESQNLDFAPAFEQQFVDSFQCALPDLSARKIKMAVNAGACDTELLYQRIQKIVEESGTDLRIVWIEGDEVLDTVQQYVSEGAKLRNITTGQSFQEWGHSPVYAQCYLGSRGISQAFINGADIVLCGRVADAAPTMGAAAYWHGWSSTQYQELAHALIAGHLIECSYYVTGGNYTGFKTLPRGKSPLLNLPIARIQCDGTFFIECHHSKDRGGEVSVNTCRSQLLYELQGKRYYNSDVVAIVDQIKMEQAGPDSVFVHNIGFEKPPPTTKVGLTAPGGYQAEVHYFIVGLDAEEKAALLEKQLRFYLDVESMSKLAFTVSGACQPNPVSQDAATVDVRVFAQAPEADALSPSNFRNKCWNIVMSTYPGATFAVDDRQAFPKPYNEYFVTIMPQALIRQRAHLPWCERVVDIKPPTDTVPYVHRQEIQPVSEPQPLLSFGPSIMAPLGYIVHARSGDKGSDCNIGFFVRHEDEYAWLRSLLTVDRIIDILQNDYNGGRVERFELPNIQAVHFLLKDHLDRGVAASSTYDVLGKNVAEYLRAKHVPIPRKFLDRGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM06</accession>
    <name>S0EM06_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437912.1">
        <property type="nucleotide sequence ID" value="XM_023570864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM06"/>
    <dbReference type="STRING" id="1279085.S0EM06"/>
    <dbReference type="GeneID" id="35405371"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11911"/>
    <dbReference type="HOGENOM" id="CLU_021768_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="249" mass="28476" checksum="4C7EFA666B0E084A" modified="2013-09-18" version="1">MVTPFSTVPNNEKDAAKSPLTPFRKEGDTYRLRREVEAMEYVRDHTSVPVPAILEVHLGNNDKDGGWILMERIPGMQLDEAWPVMTEASKARTISELKHHLSQLHRIRPSEQGWIGSCSGGPAYDHRIDNMATCGPFASVAEFNDFLVTPIKNCPRPEWVAKYRNQLPDDSSIVFAHVDISWENILLAPETGAVTGIIDWEMAGFWPEWWEYRKALYGGRPREWWIAIVKKTMKDYGELTAVVMDIEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM47</accession>
    <name>S0EM47_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437723.1">
        <property type="nucleotide sequence ID" value="XM_023570639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM47"/>
    <dbReference type="GeneID" id="35405171"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11710"/>
    <dbReference type="HOGENOM" id="CLU_098348_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="247" mass="28201" checksum="5730DFFE0D0B25A2" modified="2013-09-18" version="1">MWAQDRDSSDGSPPPSHDGDPADEAGIWEDEGISGLHGSAPSVQMDYPSGFTWDQRGPIDMHGQLGAVPDGHAVNTPWFPQHAPLVYPTPSYTPIYPAQLDSESDVSENEPDQSLNDDPQVKTEDQNYINAFDRIFNQTRELRLADVQLQNEIRTGLNSQSAMLSQSWVAVQKQLRQSRKYCEATKKKLEQVESHHHDRQDEIKELRELLMKKQKKLRRKLKRKLKRKESSDIAGKNKGSVQITWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM57</accession>
    <name>S0EM57_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_11721</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437733.1">
        <property type="nucleotide sequence ID" value="XM_023570653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM57"/>
    <dbReference type="STRING" id="1279085.S0EM57"/>
    <dbReference type="GeneID" id="35405182"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11721"/>
    <dbReference type="HOGENOM" id="CLU_046006_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="12">
        <location>
            <begin position="11"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="12">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT75687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="313" mass="35032" checksum="C246935400FAD0AE" modified="2013-09-18" version="1">MERKTDIKAYKLNHAMIRVKDPKVTIQFYKLLGLSVIQKLSFPENKFDLYFLGIDSPGSPSHGKFTFDRQGLIELTHNFGTEGDDNYRVSSGNENPYLGFSHISISVANVQSTYQTLAKAGYKFHQTLSSRNGPVIALDPDGYWIHIGEQNSSNKNVPSDTRLSSVNQYALRVTDASRSVRYYTENLGMKLINTLENANGNSKTFLLGYPSTGPFTGTEDLSRREGLLALIWQGGENELSQVHNGNDQTQGFGHICVTVDDIDASCVRLERLNVAWKKRLTDGKMKNVAFLLDPDGYWIELVQNEGFTGKANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMF0</accession>
    <name>S0EMF0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438289.1">
        <property type="nucleotide sequence ID" value="XM_023571243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMF0"/>
    <dbReference type="GeneID" id="35407575"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14123"/>
    <dbReference type="HOGENOM" id="CLU_033170_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT76243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44899" checksum="70CDEF6FF637EC6B" modified="2013-09-18" version="1">MKLTRALSFQKKRLVMRLAQRSYRARKQQAQESHRIRAEELNRALDNALATFSTLHQRLLDTPQVQSSPDLLLHLEDAVGQMVTIASSTNKKLPLMHAPDDLSTTFRRHAPGVLAPHKSTPVDSGAMTISLRTSTSKQIPVPARLERACFERVVFVLSNSTVDGSQFPALALPLQLLGVELLMVNSLRGLSLFNASVGDFKYPMHSASQLPNMYRVVEGEYKAVLRMPAPFLQRIVRGKTRTILDTNSPHLQGEWLEAMDVEEYLEERGIYMCNAVTSGTATTGNTMYRSSVPGDAQSIPMEQRAFVSSLAGFPGHEPADYLAFGLPSPRQWKRSATRQIHSSAIAGDLQSDFNQKTTQGIETASRVTVNLDKLVYLLAENAMCLGPVPGIRKADVDASIRGSITLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMS3</accession>
    <name>S0EMS3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435791.1">
        <property type="nucleotide sequence ID" value="XM_023568625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMS3"/>
    <dbReference type="GeneID" id="35402937"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09469"/>
    <dbReference type="HOGENOM" id="CLU_036517_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="316" mass="35867" checksum="CA864E1CE27D4D7F" modified="2013-09-18" version="1">MNYNDAKGYDFDSGNTNIDPAVLRELPEGCKVASIDSHGVSFWAKTGRIDVLLKDGTPQSFFIKVLSKEIGMSMTEGEFHSMSAIHGVVPEFVPKPIACGTYENIPNTHFFVCEFREITEDMPDPDEFASRLSAMHQKSASPIGKFGFHITTYAGNLPQYVAWENSWEKFFTKSMRQALDLEIAVKGNNDELEVLSQALFEKVIPRLLRPLESGGRTVKPSLIHGDLWYANARIDVESDQPLVFDACCFFAHNEYEFGQWRPACNRFGDEYIAAYNRFVQISAPEEDFEGRLDLYRLRFDAHVSALFVDNETLRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN53</accession>
    <name>S0EN53_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to TOB3 (Member of AAA-ATPase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437430.1">
        <property type="nucleotide sequence ID" value="XM_023570298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN53"/>
    <dbReference type="STRING" id="1279085.S0EN53"/>
    <dbReference type="GeneID" id="35404865"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11403"/>
    <dbReference type="HOGENOM" id="CLU_004471_2_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="697"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1057" mass="119668" checksum="66D1DC5021586B14" modified="2013-09-18" version="1">MESPVSPNNPASFSPVPQSSPQIGAPSEVTVPAPASKPLSVKDSQAQNAETEEPVAASDSDLRKKVLLAVHVLEDEVKELHSLLSDSVTMNLDEHLKLIKGLVKETNQKVGQIDDDGDQTKSKPQKENPAVVKADQQDDELVCSVKRCSMASWSKEQPKPEHVIAAHYISPVMINTTSEVRGAGKGNTDRQERPQRVELASDVLIHELEDIAGIDLETQASVLFAPPYKLFIKYYDGICERLLFLQNNIPSECKKCDAPCEKAFPVPLEARTPTLATSIAKSADDAKRPEKRSSSEGEPPGSKNDKSSDINDDASMKRKEWITRMDHLRLLKEFIDSELAPQLKVFAKANTSDLEKIAFEDLYFLFSAGDVVFFKDRGYDRLGRVYAVTGGQQRKQRDSTRFDPFRDAKDKSTEGYAYNSTRGSWNSLTVNYYTMEYDGYYLGPSDACKHIRHYTGERNITDLPIFPLRFHKMKVEIERRLMERGKRYCSSYGHKSYSGTTCPSDNKESPEEIFGDMFVDFKDYYRMPPGWTPYDYRSRTRHPPSRPELGNIRPLESDPSETQETVSDDTQYHLYDKEVDDKSFDDFMMSHLNELEVVKLETDQVPVKSLLLLPHWVPAYFFRTRRYERVDVDKIQDIDKSDEARDSSFEDLVILDSHRSLLLGLVRNLVVGSNSDTGPSGVGDGSTQIDIVRGKGRGLIILLHGPPGSGKTSTAETLAAYSRRPLYPITCGDLGTSPDAVERTLVEHTERAQRWGCVLLLDEADVFLSRRDWRDTNHNALVSVFLRQLEYYSGILFLTTNKVGVIDEAFKSRIHVSLAYPNIKLQETLHIWEGILNRLEKDNQTARIRVKFDRSALLSFAKRHYKCHESTSSTWNGRQIRNAFQLAISLGHHDRDQKLRAANLTDEQAIASGGKKWTSVRLTTANFDNIATTAREFEDYLQNTRGHDSEIAKNLSLRHDDDTEDTPTSSQFNRMQKGYKEQSRAYLSPRHSSHERGASRSSHGYTSGRPRLGGQHESTAESSRRIRNQEIADEQDRNDQDEEHEADIIDDISSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENE7</accession>
    <name>S0ENE7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438308.1">
        <property type="nucleotide sequence ID" value="XM_023571266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENE7"/>
    <dbReference type="STRING" id="1279085.S0ENE7"/>
    <dbReference type="GeneID" id="35407554"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14102"/>
    <dbReference type="HOGENOM" id="CLU_002865_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485816" evidence="4">
        <location>
            <begin position="23"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT76262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="613" mass="66857" checksum="DFC08227A7E08998" modified="2013-09-18" version="1">MSPLSTWVLATVSTALVSTVDGYNIPRSAHQACRISNGSEILPAYDYVIVGGGTSGLTVADRLTEDANTTVLVLEAGIFAADADVLPVYNGGTQRQPRFYWQSKPQENLDNRTVPVWLGKMVGGSSGVNAMMASRGSSMDYDRWGKLFPEANGWDWEGMLPYFRKGLHMNPPAPQMAARFNISTNPKYWGDDSAIQAKHMSKAFYELPGIEPVEDSGAGGAGVYWFPTLMDHFRYERSFAENSHYRGLSRPNYHVAPSSRVRRVILNKGVATGVEFYGADGLLTVKAKKEVLMAAGAIHTPQLLQLSGIGPKKLLHAAGIKTQVDLPGVGQNFQDHINIGVSITLEGLKKIHSNPSDMANGTDFKRWADEAWAVNRTGPYSIAWGNLAGWLPLSAISPERHLQLADQLEKQDHASYLSNDVHPTVAKGYALQMKNMAAAMRSKDVVFARYLVDANTGASAPILNQPMSRGSVTVDLKDPYNSNPVVDFGSLRNPVERSVLVEMVKWYRRYNSETSLSKLSPNETAPGVDVVSDEDISAWIPKALFPTDYHPAGTAAMMPLDHGGVIDQKLRVYGVKNLRVIDASIMPSLPGSNTCQPMYAVAEKAADIIKSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPJ0</accession>
    <name>S0EPJ0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to 7alpha-cephem-methoxylase P8 chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437281.1">
        <property type="nucleotide sequence ID" value="XM_023570123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPJ0"/>
    <dbReference type="STRING" id="1279085.S0EPJ0"/>
    <dbReference type="GeneID" id="35404709"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11247"/>
    <dbReference type="HOGENOM" id="CLU_042688_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="276" mass="31357" checksum="B4A25C25B4B534BF" modified="2013-09-18" version="1">MSSATEIPRGDITVPLNFYGPPADGSEPYFIVNKEDGNKPEFNFSDNSVDVTIHDIRSSENTFCIDHDAFQVVTDAPPPSEVIDFTDDEYIRANYYPEVKQSILEKLPGDIQIFIYDHTVRHQAEGGAQYRSLTRVHIDHTTNNAIRRMRQFFPTEADRLLQSRYHIVNVWRPLNKKPLESYPLAFASASTFDTADVILIQHRYKDGSIVTEVGLIKHSSSQAWYYSSGMADRERILLKFFDSDSLEEGSEIACKTPHTAFRDPRIKSSAVSISLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ20</accession>
    <name>S0EQ20_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438181.1">
        <property type="nucleotide sequence ID" value="XM_023571118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ20"/>
    <dbReference type="STRING" id="1279085.S0EQ20"/>
    <dbReference type="GeneID" id="35407686"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14234"/>
    <dbReference type="HOGENOM" id="CLU_002406_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="883"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT76135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="919" mass="105902" checksum="C2B81795F09650CF" modified="2013-09-18" version="1">MASRPPLPKPNGFQRALADFQNRLKPAERQQFKVTTLDELKVTILAIQSQQRSRKKMMHMGRLVPFLEAMEQFGKVIEVFLNVSEVLAFVWGPMKLLLLTAINWTESFDTLLDAYQRIAENFPIFEGYQSTFSQNDKMQSVMEHAWSNILEFHIKALRIFEQSMLKQFFRSLWKDFKTRFQSILDDLKRQKELVESHANRYHIHNYENDRLKMLAEFKEASVKRSSERKAFVSQWIAAPQAIIDHEHICETLRESSEATQRPMGQWILNHEDVKSWLDKTVPKSSTIWVTAIAGAGKTVLASVIIDHLKQRDTEPVGFFYCKHGDPKKRTLLSFLKSTLSQLVAQQDQLVPYYYDEAIKSGEITLQSVKHCKTLLLHMLQNIPKAYLIVDGLDECDDNERKAILSFLQETLSICDSLNPAKLRALILSRDERDIKKALAMATMIRLGQQDTLQDMKVYIDCKASAIQDIFRFSDADREYIEQYVLDKSDGMFLFAKLVLSNLEGQPNLKCFHKEFHSLPQGLGQAYDRNLHRIRNNPNHNQRAVAEKILSLVLCSRRPLMSRELQAAISIDPQEQTVDSTLRLSLDMRDICGSLIEIIPGGAVELVHATASTYIQELGYIPRWMAELSMTYICLNYLSYECFGETSKPAILRYIHEGYFAFQDYAIAHWTDHVPALLESLKGVTLDGQSHKDDIISAFTLFAAQYDAELASTDKSREMLDAKVLRQLDHSQHVVSLWEHSTNYKALTDDRKDKVSIGKLGKALEINRPLLEATPTTSTNAIMDTHSLENFYGSNWFKCSRLSCYYFHEGFASHRDRQGHYDRHDRPFSCDDDDCPSSKIGFGSLKEFEKHRRNMHPGKGKLTQTFKRLKQLGRPGVEVAKNTCPECSFKFDSRLQFRLHLVWHNAQKTQVARKPARYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHH3</accession>
    <name>S0DHH3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to 6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423620.1">
        <property type="nucleotide sequence ID" value="XM_023568640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHH3"/>
    <dbReference type="STRING" id="1279085.S0DHH3"/>
    <dbReference type="GeneID" id="35395465"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01982"/>
    <dbReference type="HOGENOM" id="CLU_018354_10_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT61539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="594" mass="66539" checksum="3221BBD85972D34A" modified="2013-09-18" version="1">MASQRPGLPELSKEEKEKQRRLLELCMQQVGFFRGKKIPVYTPGDLEYEKSVANSNLLYRFDRPGCVIQPEHESHVRIVVHQAKTVGLPIRIKNGGHSYAGFSSINNGISIDLVNMKRVDLDIANKNNMTITMDAGALWAHAYHELINDHHDKLVINGGRCPSVGVSGFTLGGGLAPFTRSFGLGSDTLLEARIVTADHGIVQVSPNDSDPEKKRLFWALCGAGGNNFGIVTQLKLKVQELHHDYVVAGVYTWAPPHDSKYQTAFTEAMIKFYTASWTNNMTIDSSWLMDLKDARVDPSVRLLVYYNGLETDFDKEVDERLGDCGKVDEKDKIDNKNKSLAEELKDRTLQENSTLFLHETLVAQWSEETQKALPSNAMFRIYTSFSFTEASVKENISEIIKTLKTKLQDFKTDFKGEEGSIRVTWIHSGGKASEKGPHDSAYPWRGCVYHTYIMIEWKDKWLETKMRLFLAEFNKALRGYSMDGLGVYVNFPDATLDKDTYEKAYYGVNREELQSIKAYWDKGNIFQWPHGVQVGPHVESKGTVMEFAAPPLPPSSNPAVEGFVNPREAAGVSACISWDTFNPASGSPIVSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHZ9</accession>
    <name>S0DHZ9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_01868</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423737.1">
        <property type="nucleotide sequence ID" value="XM_023573940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHZ9"/>
    <dbReference type="STRING" id="1279085.S0DHZ9"/>
    <dbReference type="GeneID" id="35395351"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01868"/>
    <dbReference type="HOGENOM" id="CLU_034547_0_1_1"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT61656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="393" mass="41961" checksum="0B2CBCEDE5AB7A8C" modified="2013-09-18" version="1">MSSIGQIFRVTTAGESHGRAISCIIDGCPPGLDLTEADIQPQLNRRRPGQSAITTPRNEKDRVTINSGTENGVTLGTPILLTVPNEDQRPRDYGDKTIDMYPRPSHADWTYLEKYGVKASSGGGRSSARETIARVAAGAVAEKWLKQTYNIEIVAFVSSVGTIKLFADTEAMSNDPAFLSLAETLTREQVDENLPVRCPDDAIGRAMEARIAELRDEHDSTGGTVTCIIRNVPSGLGEPCFDKLQASLAHGVMSIPAVKGFEVGSGFHGAEMTGSKHNDPFVPAPALDAATQRTGIPRSRLQTKTNHSGGIQGGISNGMPIFFRVAFKPPATISQDQITALYDGSGEGVLAAKGRHDPCVVPRAVPIVEGMAAIMVADALMQQNARKMSTVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJW2</accession>
    <name>S0DJW2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to UPC2-regulatory protein involved in control of sterol uptake</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424697.1">
        <property type="nucleotide sequence ID" value="XM_023570863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJW2"/>
    <dbReference type="STRING" id="1279085.S0DJW2"/>
    <dbReference type="GeneID" id="35394300"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00815"/>
    <dbReference type="HOGENOM" id="CLU_027371_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="451" mass="51914" checksum="172285425193AB49" modified="2013-09-18" version="1">MDLNQEFTPGMLSFTDETDFDYAAFLQADDIMFGGEGAQTQQQVPSDSSDKATPPSTTSGSSSELVARTSTQKQRLERRGHTKSRRGCYNCKRRRIKCQETRPACGHCTKTGLKCEYPSMPQITHQPHHQIPLFSLQDMRFFQHFLTQCYPHHPLKQEDVWTHEIPCIAHNHEYLMHAILGFSASELMRNDASIVSSAMNHRIKAIRAIKKRLAETARSSMDHEEANAMVATCYALTFQSVSLDDGLAEYLTFIRGIMIVGMQMLFRGIKPIFENMLEPDQDALLEPLMQGLPLIPKGYTDSAMEALTNLKPLCTRPVEVEYHQHLVKMVEKLYINSWDAYKAYTSQYGWWMLLPHDTFQALIDPDNQVMMLLHSHWVAINEIMSPISGQERNVSEKYPPQRDDQPQLDPGFARWLKHINANIDLEHQIYNQWPMWVEEQLDDDITFFGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK78</accession>
    <name>S0DK78_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable ZFR1 regulator of fumonisin biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_01774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423823.1">
        <property type="nucleotide sequence ID" value="XM_023574973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK78"/>
    <dbReference type="STRING" id="1279085.S0DK78"/>
    <dbReference type="GeneID" id="35395258"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01774"/>
    <dbReference type="HOGENOM" id="CLU_007604_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="822"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT61742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="845" mass="92581" checksum="924662BDD1DB424D" modified="2013-09-18" version="1">MSTPQNVYARSPNLSNRSYDSSSVSSATSPKSLSQFAPGAMSTNPRLNVPATPQPIGIPPLPPVTQGFQPYGPMTTSSSLGHDSLASNESVASTPGPSSAHLTGPGGQGQKRAYRQRRKDPSCDACRERKVKCDATETTSCSECSSRNVKCQFTKETNRRMSSIKQVQDLEKQMERVKRENSGLRRMLQDREGPMDLDAEGGDENSFSLPAIGSEPKRRKRPAPVPELARARANVRDFSRGIWKLPAQYRERAPIFFDPPRPELPARHVVDQLLHAYCNSSHSMFPIIHMPSFRSTINDLYNSNASNRMSPAWLSMFFAVLATGSLFSPTSGSQPNSFYEPAEFLEMVNKMIDPWSNDFTLEHARALTLVTLCLNEMNLKSAAWGWLGRAVRVSQDLGMHVESGPWPVIEGEMRRRTWWMIYILDRTLATELSRPVLIDDDDCDVSLPAGVDDQFIHEGGMLVPTGAEPLTHSLLAVIHVVRSYSSLLTALRPQSMSSVHLSTLDTHLKKCLNTFPPACDPSSSVPLAPGFLAPLAYLFHARLLLHRHHLDPVYPLEARMASLESCTHIALETVSLLHRLNGSLLADSATTLLTTHIFRCALFLLLTGYIDPAVTAVRALASIDRQRDITIACGRYLSFFVSALAAKRVECTNYLTRSAPPHFGSSRPSIDQAALLQMLSRDEDLIVYVSADLQASTDASWLWAGLEREVHLHQSPSPFQHPTSATRNELFSPEARTGLDEVDNKDWGGWARLETAIRGLDGVPATTPTPSSATWTLPPPIKSETPGPAVELPRLGDVSRFGPEIPKLGEGSTAVSPVAGGSRTPSGSATAPTTSKERLSIANII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKH0</accession>
    <name>S0DKH0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable negative regulatory factor PREG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423943.1">
        <property type="nucleotide sequence ID" value="XM_023576406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKH0"/>
    <dbReference type="STRING" id="1279085.S0DKH0"/>
    <dbReference type="GeneID" id="35395130"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01645"/>
    <dbReference type="HOGENOM" id="CLU_023749_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="350" mass="38044" checksum="3B9B9EAB00B42A9A" modified="2013-09-18" version="1">MLKTSPALSASANASPTAFRYATSSPQHSSKPSPALRRRPSTRSDTPSSADAMKSSPIQRPRQYVANDSGIHGSPEVQRPPSSISQKASAHPAQSPAPSRPSQDQTVQQGQGQAPSGVSPTKRRSSPTPTNPDAVAAANSSPQTSKRAKPATPPPKVLPDRYELCAVEDMVELVAHMLAELIATNDAIRISNGGLTRFHSRTAPGISVRDYLHRLARHATLTPPLLLAMVYYIDRLCAMYQEFTINTLTVHRFLITAATVAAKGLSDSFWNNTTYARVGGVRVAELKLLELEFLYRVDWKIVPNPEVLVVYYKGLVERTPGYVLESDGSDDEDEDEDDDPEDGENEPSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLK5</accession>
    <name>S0DLK5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_01218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424328.1">
        <property type="nucleotide sequence ID" value="XM_023581172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLK5"/>
    <dbReference type="STRING" id="1279085.S0DLK5"/>
    <dbReference type="GeneID" id="35394703"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01218"/>
    <dbReference type="HOGENOM" id="CLU_017393_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="501" mass="56316" checksum="6F914B447816CD79" modified="2013-09-18" version="1">MNQYRRALGGAQADFARQMAERNNAVRPQKKFKSYDPKGVKLASGYIDRSKERDDETKDDREQQLKDLEEQLKNEEIDQDTFENRRFEIAGGDLSSTHLVKGLDFKLLQRIRRGEDIYGEKKDGAEQQPTDEPATEIDVDDEFEQLEEQEVQVVPKERTETKKKGQLSTVSLAPGKKRTRDQILAELKAAREAAKAQQGNVLGDRFKKVGVKQKAGSRIERDSKGREVLIIVDEDGHEKRKVRKVQPGAKEIDEGDRTGLLMPDKNSKPLGMEVPEQYRKKEEPEEDEDIDIFDGVGDDYDPLAGIDDSGSDSGANEDSKKMEQERMDEGGIANPSMQPPPKPQAHRNYFQGARTGLVSEEQSKAPSMSDPAIMAAIKRAAALNPIKKARDHAEEDDDDDDDGPTEGMKSEAMEEKRRRLLQMADRDDEDLDMGFGTSRFADEEDFDDSKVKLSTWGDKDDDGEGQSKGGQSKRKRGPKKRKGDANNAADVLRVMEARKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLV0</accession>
    <name>S0DLV0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to pentafunctional arom polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423594.1">
        <property type="nucleotide sequence ID" value="XM_023580450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLV0"/>
    <dbReference type="STRING" id="1279085.S0DLV0"/>
    <dbReference type="GeneID" id="35395491"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02008"/>
    <dbReference type="HOGENOM" id="CLU_044063_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF26">
        <property type="entry name" value="AROM POLYPEPTIDE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="305" mass="33906" checksum="141D223C0DCDE131" modified="2013-09-18" version="1">MASENQEQRTLHLVGIGVGHSIAPPMHNHIAQSLGLPWTFYATECATLDGLMDLARKDTTAGLVVTMPYKNAIIPRLDALDDLAATIGACNNVYRDWKDPKKLRGTNTDWRGIKGCLLEKGDQAGVPVLNKPALIVGAGGASRAAVYALSSYFQSSIIYVLNRDEQEVKDLIKDSQKLSPVPTIIHVKEGEAQKLETPYYVVGTVPDFEPQTPDELAVRANLEEFLSRPEKGVLLDMCFKPRRTRMIKLAEQKGWPTVEGTHVIGYQIEEQWRLWAGEERVKKLDREGAWKVLIDSAEKSPGINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM98</accession>
    <name>S0DM98_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to mannosylphosphorylation protein MNN4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_01839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423764.1">
        <property type="nucleotide sequence ID" value="XM_023574262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM98"/>
    <dbReference type="STRING" id="1279085.S0DM98"/>
    <dbReference type="GeneID" id="35395322"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01839"/>
    <dbReference type="HOGENOM" id="CLU_052528_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494967" evidence="6">
        <location>
            <begin position="24"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="7">
        <location>
            <begin position="94"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT61683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="310" mass="36228" checksum="E1010159FE374674" modified="2013-09-18" version="1">MRSVKSLLLWSLASFSSTTAALAFPPLFHETRDAEASSSIAKRADEKTPKYFVEAGRNIELGHYDNRYFESKVSYEEHRLVLRDLIRSYLFHMNSYGVETWIAHGTLLGWWWNGQIMPWDYDLDVQVSNNTLQWIGDNLNRTEHSWNYTETASGKFISKRYLLDINPHHVDIDRSDGRNIIDGRWIDMQNGMYVDITGLREREVDRPGVWSCKNKHRYKSQDLWPMRITEFEGVKARVPFNFNKILVDEYDTKSLVTESWAGHRWDHDNKIWIKETEEEAKQRQLDAVDRHLAEAAANPQTDESQEAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMC4</accession>
    <name>S0DMC4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424598.1">
        <property type="nucleotide sequence ID" value="XM_023569607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMC4"/>
    <dbReference type="STRING" id="1279085.S0DMC4"/>
    <dbReference type="GeneID" id="35394413"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00928"/>
    <dbReference type="HOGENOM" id="CLU_046290_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="37060" checksum="5595393F5CA3A728" modified="2013-09-18" version="1">MEPVPETERMEEFRPTPTPAPAAVSASASASASSSLSASPSLSPGYPSLRLQSPSAFSNLSIELPRKPPNLRRSTDPSPTSPASPSWSATPFLPYRPRTTSPLSGAHSRSRSTTSLAPPMSRTQSMPGVNGSGHILFSPQHRPGSPSGSPSRVRIPRKHADEAFPPISPVRTSVLEPEQMHERRSTSPIMGVSTSTPARLRRPSSPLRTFTSSSTGSLGTFPSTPSSSISSTSSYRSYDALSGSYGTTYSSVPSTPTSTRSRSPSISSLETIPDTPDAEEAALEAERIAQLKADADAAEGNESSDLKGKDAQTRGRTMGFGSRDKRKRWSVCGAERRGDLDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMK1</accession>
    <name>S0DMK1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425925.1">
        <property type="nucleotide sequence ID" value="XM_023571656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMK1"/>
    <dbReference type="STRING" id="1279085.S0DMK1"/>
    <dbReference type="GeneID" id="35398473"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04992"/>
    <dbReference type="HOGENOM" id="CLU_018649_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="587"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT63844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="627" mass="68613" checksum="1212B283A388F738" modified="2013-09-18" version="1">MDITKFVVQGRDQALLYGDYSTYHKSLSKKLLSCRKKLNIATKNRGKFHDHDKVTAEKIAENHEYVHLLLLTSERAWAHTMSMKSGHTSDTKGITGRTRSHIASRLTKATRAADELVEALSQTDVSGASQTDLLEAIAYASLIRGTAAFEKQSWEPSLRNYATARVTYSALATATNGDLYKDLLTETIDPSIRYAAYQLQTPRTVPIPIIARKAFPQSDPNLVKQINDIDPTILKSDEAKAKDGIASAEGAPKTLTWRSREVNIEDAQIAMAWGAVLASKDRLAKDLAEPKGRGPYELAGAYDEILMLSQDAVDATKQAIDEMRAEGVEQGDARMQSLQITRTAVNFETISWRIGRSRVLTGAHDGAPEEYNVLRKRKGKPAPEAVKPVKDIPTGKKLAKLKEKVALYDGILQNIESITELPGVANDQGLAEQIAAYVKYFEALKALAIARSHAISSNLAAALALINHADGLVEESQSNISSSDGSSNRTPLNLTVSAEDVEYLQTLLNGELQRHRAIVHADTLRKNRELSTSDAVKQPLIGSLHQYPVGGVNLSHIVEFPPKLAAIPVKPIFLDVAWNYIDYPNKAPKQQQQQQAAAAAAPAQADTPERTESPAPSKRGWFGFGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMN3</accession>
    <name>S0DMN3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_05146</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425781.1">
        <property type="nucleotide sequence ID" value="XM_023571483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMN3"/>
    <dbReference type="GeneID" id="35398627"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05146"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="24"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT63700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="545" mass="60467" checksum="7CE380A4ED7F2680" modified="2013-09-18" version="1">MGLLTLQEDRPTPKAVYNWRVYTCAAIASMAACTIGYDSAFIGTTLALPSFVQEFNFENYEPNALALVKQNIVSVYQAGAFFGSLFAYVSSYFIGRRYSLILFSLVFMVGAGMMLGANGARGLGLIIGGRVLAGIGVGGCSNMTPIYISELAPPAVRGRLVGLYEVGWQAGGLVGFWINYGINQHLPYAPGQNENVWLIPFAVQLIPAGLLLIGAVFIPESPRWLFSKGKRDKAIKNLCWMRNLDREDIYIVEEIGFIDAEIDRFNSAVGAGFWKPFAALKQAKVRWRFLLGALLFVFQNGSGINAINYYSPTVFRSIGITGTNTSFLTTGIFGVVKTVITFVWILVLIDHVGRRNLLMIGAGGGAFCMYFIGAYIKIANNEAKVAAGENPTLSSGGIAAIFFFYLWTAFYTPSWNGTPWVLNSEMFDQTTRSLGQANAAANNWFWNFIIARFTEQMFNAWGWGVYIFFASLMVVSVFFVFFCIPETKGVPLEAMDKLFETKPIWRANKIVMEELRLQDEEFRHNVDGADLREEKANAEQIEGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN47</accession>
    <name>S0DN47_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425947.1">
        <property type="nucleotide sequence ID" value="XM_023571683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN47"/>
    <dbReference type="STRING" id="1279085.S0DN47"/>
    <dbReference type="GeneID" id="35398448"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04967"/>
    <dbReference type="HOGENOM" id="CLU_013199_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="840" mass="93575" checksum="E01CB44494421C4E" modified="2013-09-18" version="1">MAQDIVAQGHLASRNQLAGLAEKERHQIEQYEKIVRFSTTVLSGKHPTIKVPSNFIPPTQTSIHPIDISTQDGTPSHQTDAHGQTIANEKQADVSATTNNSSKPYGSGSTEINPIFLEKSEDLVKAELKLQRQRLERALRDEVDQRRVTAKSVAQGEPVVEFDLNEVLTKALTLVESNAGPDTTATAAAADATNIDNASDSFDDNTFYSSQHNTPSSVLTSRVRNESQEAQVPVAESQPKINSHTAPIPRQPPIGFEQVPPGPYAPSHTRPQEAYANPDPFVGSVSVNSTSRPVQVPGLATYNADKTAPRQDRSARQSPSNGESDRRRVDYGSASRQPPREHYIDSRPPSPLIKAHERSHQNAQTSPLINTRPRPRAAEATSTSSTGTPAQVAALRNEPVAVTSPESSPQGGASDRRKAKKKKRKADRQAPETEPTPYIKAEPRSPSPMNAPSYIRPNKRQRYAQQQPDEPVYEEVRYDPHPGLYPPESVPVHNRQERDDRVPIGYDTVGFSSQRAASTTVPGTAVYRREYADDRYVSGGPYPIEQAPHVPPPHQRLSMGGTASSQVRPNNGYPRPSWPYAGAHEASPTGLRPEGDVFMAPQRPPPTRIIVDAYGREYIEPPRSTIIRHSAAPPARSGEPEIFYERTPVRRPQAMETYEEGGAVYRRRSPSYMPRRIVTQPEYVSQDYRDHRPREHSTRPIGPSGEFVEVMAPPERRRMEDGTRDYIARPTSVRPAEPVRYEVARDYGRVQSVRPEPPVRQYATSVHPESRREAVQPYAREYGGIAAEPGVVRQEYSTRPVERYYNQPMRGGEEIAFIERPRGATQEIVYADDARREVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN81</accession>
    <name>S0DN81_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to nuclear poly(A)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_01478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424094.1">
        <property type="nucleotide sequence ID" value="XM_023578262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN81"/>
    <dbReference type="STRING" id="1279085.S0DN81"/>
    <dbReference type="GeneID" id="35394963"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01478"/>
    <dbReference type="HOGENOM" id="CLU_027088_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.40:FF:000001">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055046">
        <property type="entry name" value="Nab2-like_Znf-CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22683">
        <property type="entry name" value="Nab2-like_zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nab2-like CCCH zinc finger" evidence="9">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT62013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="504" mass="54444" checksum="A5B127DBB176E50B" modified="2013-09-18" version="1">MPVEVSLNTPLAEALNAAIQPKLVEVGWGTGGADDSALAEYIILMLVNGKSQDEIAAELSGDLLGLGSDDPSTRNFSQWLFEQIDALNAQFNGGGNAAPGTSQDATTEGDVDTDMNAGDVSELNAYANPIILPRITKSLTSTRPTGPRSMRNGNQRGGRDKRMFGQMNKAMDRAGDSALHRVRGQTGSERINTHGRTPPNGPRTGRGGIGRHNNRTANLQAGLANMAAGGPQAQWMMQGGQPNSAEFAAILEQQSQMMLQMQQIMSGGGFQGPYGHQRRGGKSLFDRTQHPGRGNYRKGFNDRQSGNNAGFEGEGEDVDMSGEKREQLNPDETVCKYNLRCTNKDCKFAHQSPAAPQGTSVDVNDNCSFGAACKNRKCVARHPSPAARLAHQSELDCKFFPNCQNPQCPFKHPSMPLCRNGAGCTNADCKFTHVKTKCRFNPCLNPSCAFAHEEGQQGGFKDKVWTAGESTEHPSERKFVDDQAPEELIKGEETDVKQETDVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNA7</accession>
    <name>S0DNA7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426135.1">
        <property type="nucleotide sequence ID" value="XM_023571910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNA7"/>
    <dbReference type="STRING" id="1279085.S0DNA7"/>
    <dbReference type="GeneID" id="35398246"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04765"/>
    <dbReference type="HOGENOM" id="CLU_038290_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="380" mass="42425" checksum="6D07D167549EAB70" modified="2013-09-18" version="1">MGRKLPWKTSSTASGPERKTPVKLDSPLPTPSRAPCPGTASASRKKPRRERVIEAEGIPDSTLSSKPQRNRQYHADATRSPSTSPPPEPPKERFMRPGLDHDDRYRIVEDEFVNMAHQFTLHIHTSEYNRLKNLAKHQNADTIREIERPEIGAPTLLTRHRQEDVRRKAKQRKLLGTDANEKKDSPYVGSSLQGLMESPRKEHKWISTGLADTAATRASAGFNSQKISPLRLKQGSNSSSAKKRQMPLGDDDETDDGNDLDLATPSRTAATKAARTTHTSSPVMPRSTPRTAFSTPRTLKSAMSTTSRPGSSVKRPTTVPGGSEARKVTKSRDIEEDIDDDDPFGINKRRLQRQKSREQFRRTEEKTPSKPSLDDIPSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP37</accession>
    <name>S0DP37_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_04607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426277.1">
        <property type="nucleotide sequence ID" value="XM_023572088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP37"/>
    <dbReference type="STRING" id="1279085.S0DP37"/>
    <dbReference type="GeneID" id="35398088"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04607"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT64196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="251" mass="27998" checksum="C9EE6CB2C7D609CC" modified="2013-09-18" version="1">MSRRYDSRTTIFSPEGRLYQVEYALEAISHAGTAIGILAKDGIVLAAERKVTSKLLEQDTSAEKLYILNDNMICAVAGMTADANILINYARQAAQRYLLTYNEDIPCEQLVRRLCDLKQGYTQHGGLRPFGVSFIYAGWDPRRQFQLYLSNPSGNYGGWKATSAGANNASAQSLLKQDYKEDCTLKEACGMAVKVLSKTMDSTKLSSEKIEFATVGQTEDGKIYHRLWSADEITALLKEHDLAKNEETEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP99</accession>
    <name>S0DP99_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425308.1">
        <property type="nucleotide sequence ID" value="XM_023573618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP99"/>
    <dbReference type="GeneID" id="35393632"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00147"/>
    <dbReference type="HOGENOM" id="CLU_637854_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484797" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48528" checksum="853FD4AB2B940D99" modified="2013-09-18" version="1">MAPTMNRVAAFGLLLLGLPSSTLAKPIEIQPRQNVPGDTPFVSFDACSDSQRQDIEKAWADVVTLVGVSKQFNPPGTIESRIFGDDINLRFEDISRIYTIFHNIEELSKNGRKMQISCQDVYQDHRGANDQVTCGNVIQSSSGSIGAYAFSTEATIEKSTIVLCDPFWAPGQEFLGEIVDNLRKAPEGDRKNPNLMVGKGKILLHELTHLPALAETSTNDVIVTDQLLNDDSNVKAYGIRMVERFARNKNWRARTAKNADSYAWYATEKYFEGMFGTPNAAYEKRDGEEDDTPTEDPAPPAGPTKALNIILENKRHGVPMDKDFYDTMNWLFYSTDYGTASQCALNPALAINADVSIDTLSIDALRDDHFPGGTFDVKTQDGDCQYKNDGTGNPGALWCDDQGHSCRAHPDRRTFTYCRDLDKSAQIQHAAMVVCEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPV4</accession>
    <name>S0DPV4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to laccase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_04193</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426655.1">
        <property type="nucleotide sequence ID" value="XM_023572551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPV4"/>
    <dbReference type="STRING" id="1279085.S0DPV4"/>
    <dbReference type="GeneID" id="35397674"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04193"/>
    <dbReference type="HOGENOM" id="CLU_006504_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="77"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="203"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="434"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT64574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="585" mass="64801" checksum="BB78F781B08BFF7E" modified="2013-09-18" version="1">MGNTNSSPFNLGDLGQLSQLQTNGESSYGTFDAPDLPTFLTDNPTPNGYPWSTMNSQTNYYQDQPNTGVIRRYDFTVSRGTIAPDGYELSTILVNGQFPAPLIEANWGDTIQVTVHNDLDDEGVSLHWHGILQKGMPWEDGVPGVTQCPIPPKKSFTYQFLADLYGTSWYHSHYSAQVAAGLFGPLVIYGPREKKDYDIDIGPVMLSDWYHKEYFDLVEEIMKPGGNGVVLSDSNLINGKMNFNCSSVAPGDKTPCKSNAGISKFRFKRGKVHRLRLINPSAEAIQRFSIDGHTMKVIANDFVPVQPYDTKVVTLGVGQRTDVLVRANGKLDSYWMRSNMSAICSLGRAPAALAAIYYDNANQKKAPKSQAWDIPDPETCANDDLSITKPVMKLPLPPADKTIELDISSFKNASNVTLWTLGGVAARTNYNSPTLLLSKLGNHTFEPEWNVINTGKAKSVRVVVNNKTPVAHPMHLHGFNMYVLHEGPGSWDGTIINRHNPQRRDVVQIRGNGHLVIQFDAGENPGVWPFHCHIAWHVSAGFLTQFLTNPDQVKKLRIPNVVAETCRQWGHWTLSNIPAQIDSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ05</accession>
    <name>S0DQ05_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424734.1">
        <property type="nucleotide sequence ID" value="XM_023571285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ05"/>
    <dbReference type="STRING" id="1279085.S0DQ05"/>
    <dbReference type="GeneID" id="35394262"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00777"/>
    <dbReference type="HOGENOM" id="CLU_074897_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24305" checksum="1CCCFC42525D0A25" modified="2013-09-18" version="1">MGWLWSSTPPSEGKSAAPVKEAPSVTSISTTATTTSDPSTSAPSNSNTDPEIQKFIDLFEAEKNAKPSATEDQQQQNSSSSKLPSWLSLKKSTRSSTPTPADIPPRDALSEALLPTDMSCRQAFDQAWACNSMGGQFNAVYRYGEMRSCSEHWDDFWFCMRTKSYSPEMREKAIRDYYRAKEFTKYGPGKPSSEDVWESREGKVPEGTVFNEPVEPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQJ6</accession>
    <name>S0DQJ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425763.1">
        <property type="nucleotide sequence ID" value="XM_023571462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQJ6"/>
    <dbReference type="GeneID" id="35398646"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05165"/>
    <dbReference type="HOGENOM" id="CLU_014990_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF8">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_2G17475)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485171" description="TRP C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="83110" checksum="9249AC23CCA4D39B" modified="2013-09-18" version="1">MSSNISRNILISCLLLAVLSQTLPASAEQIWQSKPWIRKYPCSRGYQGIGSIEINPFWIDSFRGSWTIDAESRSASLELNILAVHNASLMSCEDIDVSSLRNSIDFQVLGRSVGKLENFSSNCPLPITDTLTPIEKTRLSSYHLLYSFQNTHQFQTLESTFRFRQDDGQELDCGKAKITPELGDSISAVLKFMPLAILIIVVLSSWRVNQSSLIYTHGLNASSLWSVILDVTSYLRYLQFAFITASMSIEYPGFFVPAVSELSWASLLYWSGPFSNGYMYEGPTGGMYTSNASYGLGFMTQMLRYPNMLNTLANSLINLIILICPIFFLFLVSFWTFSRSSSVHSPPFLSILQKAASSTIGVALCFFSVPLLSYISYDLILTGYLPNYRIGLAVVMLLIILAAGHFLVQVLDGQAGDQLKPPQVSRLETNNPSVDFHTLWRLLSRHIPHTMPLLQAIGVGSLQDFPLAQLFMLIACEAFIIISYFNSKRSMLIKASTTMYVSAMRLIILFLISVFAMPITEATRQGVGYVVLCLHGMVILIGFLIKHTWKVYKTIFRSTSVDQSSSAHSTSGESNLSNSFNMNSLEANSTADLLEYRQAPSREPSTRDFQPDPSTFYRPPRSGAISPAYHAPRLAAVSTTPRSPIAGKSSPSTGHFSIDLALSEVALQPDVDYSLRESDRFYGIDEERVFVSSTSCPDVDTNPGPSTGIRPHGAGRQNKLVAGFTNVFTRPMPKVREKGFQVKRPPRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRY9</accession>
    <name>S0DRY9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to DUF718 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427292.1">
        <property type="nucleotide sequence ID" value="XM_023573836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRY9"/>
    <dbReference type="STRING" id="1279085.S0DRY9"/>
    <dbReference type="GeneID" id="35395622"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02139"/>
    <dbReference type="HOGENOM" id="CLU_100689_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT65211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="121" mass="14252" checksum="2BF9012678D18D50" modified="2013-09-18" version="1">MSDKPNRRFAQIIKLKPQHIEKYKQLHANVWPEVLAQNEQSNIRDSDTIFYDDQSHYLFATFRYVGTDFASDMKKMAQNPSVKEWWKITDALQESLVPGAVSSESVEPSWWKPIEEVFYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS71</accession>
    <name>S0DS71_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426318.1">
        <property type="nucleotide sequence ID" value="XM_023572134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS71"/>
    <dbReference type="STRING" id="1279085.S0DS71"/>
    <dbReference type="GeneID" id="35398046"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04565"/>
    <dbReference type="HOGENOM" id="CLU_270627_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1202" mass="129416" checksum="D6F38668AE22CCD0" modified="2013-09-18" version="1">MSEGLPLKPLQPARPLSQVQLSPGSAEEAIASIRAFGTSFPKAAGSQAAQTSTTLHLPTVSVAEQSQQPQAGAPPAKKPRRRQPKKAQEQSSTSQLSIPQGPQQVQQPQTVAPPSQKARQPRKSLKRSIDSVEPSTSQEGPATKKPALQVSQPTQPAIQVLPSTVALQASQQTQQSQTQVPPSQKAKQPRKSLKRSIDSVEPSASQEGPATKKPALQVSQPAQPQIQAPPSTVAQQAPQPTLPEIQASQSTQPEIQVTPSTVALQVSQSAQPEIQATPSTVALQAPQPTQPQIQASPSTATLQASQSPQSGTQAPASTIDLPPHQPAQQLQFQAPRTDPIPGAWWEVPGFSEAFKQFHRDRYGKEGTLKPFVVQGIIDLAVNEWKRLHAAAAARQAAENQGAAANPTAPGQETDPVSENLQALVSLSGGPSSEMGADDQQADSDPPIDPQLQAEYEASSMDPRAHKIRFGGVTLSEAGLGPDPALPKDDVDGRFKMIVAEIKNQTQAQNIPIPPLSALPKLPPKPFVGGLYLMPPGVQDARLKEVLKQRNVVILKRQKDVALARNNLAARRTRERREEKEKNRREMMAKLQLQMNWWRLKAISLGANAGAWNALHQDYKNKMLQDMNEKVCKAESKQSKEIKDIRGAEHSARNSKNSRLTNLDKPKKEKGVQAIIAAIEAKDREIQEAESQGLNPPEMDLTEFINMVFPDDAIHVDTAAAAGEATGEATGDTAEAPTPINDNQNDSINANTSGPININSVPVETPANIGESADAGGAIDHVNTTDVNNTMDVGNHINNNNNGSMALSNTMDENSLTKDGSAPNTDNMVSALDMNNSSLPPGQSAYQPYTQTDNTPTMSMDFQGALLNNYDMQGNGMQSSGMQSNWYPVGTMMDNEFQVDALSNFNPQNNDFLSLGSQDNGFMQSNPQDTLFAADDMQNINMTTNGFQRITALDDCTQGSTSLDYPMQDNTPLDTSLYSNASLGNSTQCSTSLDYSLQGDAGFDTSIFSNASIDSGTQNNASFDINFQDNTSVNYGPQGNLPVNNGLYGAAPYNNFIQDNASSSTNPQGNGNATNKEKPYRVTKASKPTRASKSNGRNVKKAETARGEITGADLPRVANPTPNNAFNPAVLARARLDHIDHTDRCAFGGRPPSASQQIITPRASDFVNDKYLTNETSFTREGNQSLFNTDYEMYPSDDERNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSA3</accession>
    <name>S0DSA3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425524.1">
        <property type="nucleotide sequence ID" value="XM_023571663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSA3"/>
    <dbReference type="STRING" id="1279085.S0DSA3"/>
    <dbReference type="GeneID" id="35394228"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00743"/>
    <dbReference type="HOGENOM" id="CLU_007383_12_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="349" mass="38702" checksum="316EA99C43A9EC5A" modified="2013-09-18" version="1">MATKILLTGVTGFVGGTAFAKIHDAHPDYDYTLYVRSEDRAKTISKKYPKVRFVYRDLASTDVIEKTASEADVVVHTAESADSLPAAKAIARGLASGHSKENPGYYIHLSGAGILTWYDLKNQRYGEPPLPEQSYHDINDIDRILNLPDEAIHKDVDNAVQSIDSGIVKFLIVSPGVIHGTGLGLFNTTSMTVPGLTRATFDLGYTPFVGAGKAKWDYVHVEDLADFFDKAIEATQDPSKKEDPEIWGKKGYYFVSGGQHQWKDLATWVADEVHRQGYIPESSTQSVTFEDVIKNGYKAGIAWAINSRGESERAKKFLGWEPKAPSLKDTVRESVVWEAEILDLKPKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSK1</accession>
    <name>S0DSK1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to beta-lactamase class C and other penicillin binding proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_02377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427517.1">
        <property type="nucleotide sequence ID" value="XM_023574099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSK1"/>
    <dbReference type="GeneID" id="35395859"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02377"/>
    <dbReference type="HOGENOM" id="CLU_020027_0_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027279">
        <property type="entry name" value="D_amino_pept/lipop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012856">
        <property type="entry name" value="DAP_B_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009622">
        <property type="entry name" value="PRK13128.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07930">
        <property type="entry name" value="DAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50886">
        <property type="entry name" value="D-aminopeptidase, middle and C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="9"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="D-aminopeptidase" evidence="4">
        <location>
            <begin position="354"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT65436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="536" mass="58774" checksum="D6BE1ADB38A42EFC" modified="2013-09-18" version="1">MPVSKELVQDILKAIPARIRGPGGAVAVLSDGALVDQRVWGYADFNRRIPMADDTLIPICSISKQMLCGLVADLERNPTPKLAEKGDVKTQFEEKLKEILPELAKTGELKIDHLCNNRSGIRDYWAITLLWGAKPEDPYSISEHNEKVLKTIKSTHFTPGTEYSYCNTNFNIVARVVEATTGESLSDLLNARIFGPAGMKTAQLGADTAKLPPPCVGYEGDEDRGYIPAENRIEWAGDAGIIASLGDMIAYESFLDRSLFDPTSWYRAIFKPTSFTDGVPSIYSQGLGHSQYGSVSGIGHGGALRGFRLYRAHVPEERLSVVAMFNHEADAATLVEHIIQTTLALQKPPPPTLVDASSAWPGIYLDDGTQLAVTIKNGKKGQIVVNYANYAEPVNLTDPERGESRAMVAVIDGDNLRIHRLKENRTLNAKRLKIGDTPIDNSLFTGDFYSEEIGSTFHCVDQGGLMFGTFEGFLGHSPAQFMRYLGGDVWALANPRGMDAKPPGDWTLVFHRDEKGGVTGVTIGCWLARKIEFVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSN1</accession>
    <name>S0DSN1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427542.1">
        <property type="nucleotide sequence ID" value="XM_023574130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSN1"/>
    <dbReference type="GeneID" id="35395886"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02404"/>
    <dbReference type="HOGENOM" id="CLU_1652288_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="160" mass="17210" checksum="954805153950E7E8" modified="2013-09-18" version="1">MQNNGMQLRTIPTWDLHKILQVAITKRPGVGIGESTGQSRLRLAVAARRLEEEITLFNREKQPTPAEPTPAAEHDPDVEMPDEPAEPTAKPAPAPTEPTPEESSKPASNPTPTPADIDIELTDDDESPDDDEIPEGQFLTPPAIVLPLGLGTTNTIDAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTD9</accession>
    <name>S0DTD9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable ubiquitin-conjugating enzyme E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426728.1">
        <property type="nucleotide sequence ID" value="XM_023572642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTD9"/>
    <dbReference type="STRING" id="1279085.S0DTD9"/>
    <dbReference type="GeneID" id="35397593"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04112"/>
    <dbReference type="HOGENOM" id="CLU_063065_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="140" mass="15786" checksum="672F01DB241952BC" modified="2013-09-18" version="1">MSAKVPRNFRLLEELEKGEKGLGAEACSYGLEDPEDLLMSKWNGTILGPPHSVHENRIYSVKMHCGPEYPDKPPSIQFISQVNLPCVNPTNGIVDPNQLPCLAQWKRENTMETVLIELRRYMASSQNKKIAQPPEGSTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTP9</accession>
    <name>S0DTP9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426019.1">
        <property type="nucleotide sequence ID" value="XM_023571770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTP9"/>
    <dbReference type="GeneID" id="35398371"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04890"/>
    <dbReference type="HOGENOM" id="CLU_064119_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="2">
        <location>
            <begin position="104"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="368" mass="41000" checksum="DA33152D1C3BE41C" modified="2013-09-18" version="1">MAIYSSVPPPEQQSASNTPTPAATNPPLAALHVHSPPTPVKNGSIDIDAWTVSALQSLSVSPIARGTGTPLAIPLDEVVKDKSNSPGRNVNLDEDEAPISTLRRPPSRRDSQRKRDLVLKGKEGSRQRRRWENDRLMGVPNAQPPLPSDYEVHPTHPIHRVPYQLAQFWDRGVRKQVEDKTARLLAERKKQQLKAGSATGLGAGEVPRDLREATKRSPVVRTWVRSLEEPVRQYLANQQAMATTSAVTADEDDDSAAEQMDSDDEEIVFVGRNGAMRELREKKATWKHAHREVSQETVDSGMLFDSFGTDESAAFKRWLTHTISDYYGIQSRSVNLSNPTRRVVYVGLKTSRGALPLRTLPRPMWEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTW1</accession>
    <name>S0DTW1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_02992</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428080.1">
        <property type="nucleotide sequence ID" value="XM_023574789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTW1"/>
    <dbReference type="STRING" id="1279085.S0DTW1"/>
    <dbReference type="GeneID" id="35396474"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02992"/>
    <dbReference type="HOGENOM" id="CLU_025113_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="14"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="300"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="511"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="285"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT65999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="551" mass="61348" checksum="2C0B91147F3E4D49" modified="2013-09-18" version="1">MAPKNKFELKTPKGTKDWEGKDMVIRDHIFNTITQVFKRHGGVTIDTPVFELREILAGKYGEDSKLIYDLADQGGEICSLRYDLTVPFARFLAMNKQIQNIKRYHIAKVYRRDQPAMTKGRMREFYQCDFDIAGTYDPMLPDAEVIRIITEVFEGLGWNGGYTIKLNHRKILDGIFQVCGVPEDKIRTISSAVDKLDKLPWADVRKEMTEEKGLGGDVADRIGEWVVLKGKQDLLQKLQSTESLAANESMKKGMEDLALLFEYLEAFDCLDRVSFDLSLARGLDYYTGLIYEVVTQGSAPEVTPGQENAESKPSKKKGKKGSEDDDRSDDPTVGVGSVAAGGRYDNLVGMFSGKSQIPCVGISFGVDRIFSITKAKMAAEKNAAVRSNDVDVYVMAFGQGYLKERMSVCAKLWESGIKAEFLYKVKPKLPAQFKAAEANGVPFAIFLGEDEVKSGKVKIKEMGLQEGHPEKEGILVSMSDMAKEIKVRLQRKRELDEMTRQAEGLRVVHGIKGDEVKDAEKEVEDASPETTPTAVEATPGTEEPPHNNPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTY1</accession>
    <name>S0DTY1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to F-box protein Fbl2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427986.1">
        <property type="nucleotide sequence ID" value="XM_023574674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTY1"/>
    <dbReference type="STRING" id="1279085.S0DTY1"/>
    <dbReference type="GeneID" id="35396371"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02889"/>
    <dbReference type="HOGENOM" id="CLU_025082_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="174"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="696" mass="76571" checksum="F83FC5C423703B9E" modified="2013-09-18" version="1">MEVHEITPGAPSPSLSPNPGPEGVSTAPAPDMPVKGKSRHRLIQRIQRISSTPSLSGLRRSRSVGSRGSPYSTRSTLSCVSLAATGPPQTPYSARSSTPQPSPLGLPSALSSTPQSSGEFPFDTPDDFLAIRRVENATPTTTPGTAPLPPEFRSKQDVQIRTRPGVKPIQKQPFRFWDKMPNELQIHIFSFFQPRELVQASRVSKAFYKACFDGQLWTSLDASEFYREIPAESLARIIVAAGPFIKDLNLRGCVQVEHYKRTEVIVKACKNLMNATLEGCQNFQKSTLHSLLRNNEKLVSLNLTGLTAVSNTSCKIIAESCPQLETFNISWCGRVDARGVKAVVEACPRLRDLRAGEVGGFDNVATAEAIFNTNNLERLVLSGCAELNDEALQIMMHGVEPEIDILSERPIVPARKLRHLDLSRCVRLTDAGVKAIGHLVPDLEGLQLSGCKLLNDDALESILASTPRLTHLELEDLENLTNSILSEHLAKAPCASSIEHLSLSYCENLGDTGMIPVMQTCTNLQNVDLDNTRVSDLVLAEAAAMVMKRSQRSIETGTRPRLSLQMVVYDCQNVTWTGVREVLFRNTQVKAVSGQPGRVSYPTEMIGLKCFYGFQMTVDEHQKRVLRGDLASAGRLERKWADYMQATEEAGITGAGYRRRRRRAREAQALHLDEEDAGFGPTGRRRARTLGSCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU46</accession>
    <name>S0DU46_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable farnesyl-pyrophosphate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_03086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428170.1">
        <property type="nucleotide sequence ID" value="XM_023574892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU46"/>
    <dbReference type="SMR" id="S0DU46"/>
    <dbReference type="STRING" id="1279085.S0DU46"/>
    <dbReference type="GeneID" id="35396568"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03086"/>
    <dbReference type="HOGENOM" id="CLU_028376_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT66089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="347" mass="40214" checksum="23803057361B289F" modified="2013-09-18" version="1">MAQQTTLQEFNSVYPKLEEALLDHARSYKLPQEQLDWYKRSLEVNPLGGKCNRGMSVPDSVSLLLEKPLTEEQYFQAATLGWMTELLQAFFLVSDDIMDSSITRRGQPCWYRQEGVGMIAINDAFMLESAIYTLLKKYFRSHPAYVDLIELFHETTFQTELGQLCDLLTAPEDNVNLDNFSLEKYSFIVIYKTAYYSFYLPVALALHQLNLATPSNLKQAEDILIPLGEYFQIQDDYLDNFGKPEHIGKIGTDIKDNKCSWLVNQALAVATPEQRKILEENYGRKDDEKEKVVKKLYDDLNLEQRYLDYEEKVVGQIRERIANIDENDGLKKTVFEAFLAKIYKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU69</accession>
    <name>S0DU69_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02983</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428071.1">
        <property type="nucleotide sequence ID" value="XM_023574777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU69"/>
    <dbReference type="STRING" id="1279085.S0DU69"/>
    <dbReference type="GeneID" id="35396465"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02983"/>
    <dbReference type="HOGENOM" id="CLU_023208_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="55"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT65990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="452" mass="49023" checksum="29592A848D9A4B45" modified="2013-09-18" version="1">MRSLLLQCRHRGILLGSRPQRLRFLTTLAIETSCDDTGVAVLRHTPGSTELLFNERISSDNRAFKGIHPIVAAKGHSEALAPLVRRAIDSLPAAEDDGQKFCDAGGVRRQVPDFVSVTRGPGMRSNLGIGLDMAKGLAVAWGVPLVGVHHMQAHALTPRLVRALGMSMGEDEVSQEGPEFPFLSLLVSGGHTQLVYSRGLTEHSIVATSGDIAIGNLLDQTARDILPPEVFEASEHVMYGRLLEAFAFPPKNSSTSAYEAVFTPPASRSAEMSPPSTGYEWNIPTPFRQTRKLAFSFSSIYTHVHDLATSRPSMPLPERRALAQHTMMAAFTHLAGRLCIALDDKPELRAAKTLVVAGGVASNRFLMHVLRSMLAVRGFGDIQIVAPPAELCTDNAAMIAWSGMEMYQAGYESELTVTGIGKWYMDPEVGDGILGVDGWVRRDTRGSTPEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUD1</accession>
    <name>S0DUD1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable YDJ1-mitochondrial and ER import protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_03046</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428132.1">
        <property type="nucleotide sequence ID" value="XM_023574848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUD1"/>
    <dbReference type="STRING" id="1279085.S0DUD1"/>
    <dbReference type="GeneID" id="35396528"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03046"/>
    <dbReference type="HOGENOM" id="CLU_017633_10_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0140455">
        <property type="term" value="P:cytoplasm protein quality control"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:protein aggregate center assembly"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:protein refolding"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein targeting to mitochondrion"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:tRNA import into nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ subfamily A member 2"/>
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        <property type="entry name" value="DnaJ domain"/>
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        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
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        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
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        <property type="entry name" value="DnaJ_domain_CS"/>
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    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
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        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
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        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
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        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="135"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="135"/>
            <end position="218"/>
        </location>
    </feature>
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        <location>
            <begin position="360"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT66051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="416" mass="45684" checksum="88E6CD3202C733F7" modified="2013-09-18" version="1">MVKETKYYDTLGVAPTATEQELKKAYKVGALKYHPDKNAHNPDAEEKFKEISHAYEILSDSQKRQIYDQYGEAGLEGGAGGGGMAAEDLFAQFFGGGGFGGMGGMFGGGGMNRGPPKARTIHHTHKVTLEDIYRGKISKLALQRSIICPKCEGLGGKEGAVKRCTGCDGHGMKTMMRQMGPMIQRFQTVCPDCNGEGEIIKEKDRCKQCNGKKTTVDRKVLHVHVDKGVRSGTKVEFRGEGDQAPGVQAGDVVFEIEQKPHARFTRRDDDLLYNCDIELVTALAGGTVYIEHLDDRWLAIDILPGEAISQDAVKMVRGQGMPSPRHHDFGNMYIKFNVKFPEKNWTEDPEVFETLRKVLPPATQNAPPGDAMSEPASLEDLDNTTQNRVFGNSDGMMDEDDEDGHPGGERVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUT5</accession>
    <name>S0DUT5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to CBP3-required for assembly of cytochrome bc1 complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428307.1">
        <property type="nucleotide sequence ID" value="XM_023575060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUT5"/>
    <dbReference type="SMR" id="S0DUT5"/>
    <dbReference type="STRING" id="1279085.S0DUT5"/>
    <dbReference type="GeneID" id="35396718"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03236"/>
    <dbReference type="HOGENOM" id="CLU_053729_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="120"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="307" mass="34649" checksum="94A029D60B1140FC" modified="2013-09-18" version="1">MSMACETCRTQARAVLRAAMRAGASRAAAPTTRNFLPPAAVVTRRHFSNTSSRSLLKGIGKSMAEPYRVLGATEQLFKASAKAADYHITEKERKDDQVQLAEDGEEIGHSLNPDSPWHHTFKLPPTFSTWSHVTMLHLYLINTRIRCFDREGFQNWQHQLTDHFFFECEKKMHIDHHITSSALRQRYLKDIFVQWRGLLLAYDEGLIKGDAMLASAIWRNLFKGSADADPRALLAIVGWMRSTLLQFEAVSDNNLAAQLPVIMAKPVDVFWTRLEKQLGGQQEDSLPAKEVKEEPVSAEETAKVSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVE7</accession>
    <name>S0DVE7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_03483</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428532.1">
        <property type="nucleotide sequence ID" value="XM_023575335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVE7"/>
    <dbReference type="STRING" id="1279085.S0DVE7"/>
    <dbReference type="GeneID" id="35396965"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03483"/>
    <dbReference type="HOGENOM" id="CLU_024336_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02130">
        <property type="entry name" value="PA_ScAPY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000093">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="AMINOPEPTIDASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005146094" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="10">
        <location>
            <begin position="150"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="262"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT66451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="508" mass="54983" checksum="0D30C020442884CC" modified="2013-09-18" version="1">MTTKGLCLVAATAALQGVSALQIPLNLQVPKLSWNLFGDDLPLVDTKELQKSIKPENLEARAKDLYEIAKNGEEEYGHPTRVIGSEGHLGTLSYIHAELAKLGGYYSVSNQQFPAVSGNVFESRLVIGDSVPKQASPMGLTPPTKNKEPVHGTLVLVDNEGCDESDYPEAVKGNIALVLRGTCPFGTKSGNAGKAGAVAAVVYNYEKDEVHGTLGTPSPDHVATFGLGGEEGKAVAKKLKDGETVDAIAYIDAEVKTISTTNIIAQTRGGDPENCVMLGGHSDSVAEGPGINDDGSGSISVLEVAVQLTKYRVNNCVRFAWWAAEEEGLLGSDHYVSVLPEDENRKIRLFMDYDMMASPNFAYQIYNATNAENPKGSEELRDLYVNWYEEQGLNYTFIPFDGRSDYDGFIRGGIPAGGIATGAEGAKTEDEVEMFGGEAGVWYDKNYHQIGDDLTNVNYTAWEVNTKLIAHSVATYAKSFKGFPEREIETSVQGYSDKTKYHGSKLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVI1</accession>
    <name>S0DVI1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to aspartate aminotransferase, cytoplasmic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428635.1">
        <property type="nucleotide sequence ID" value="XM_023575456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVI1"/>
    <dbReference type="STRING" id="1279085.S0DVI1"/>
    <dbReference type="GeneID" id="35397073"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03591"/>
    <dbReference type="HOGENOM" id="CLU_032440_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="27"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="466" mass="52769" checksum="9507726E0BBC0F75" modified="2013-09-18" version="1">MFSSFRKGPDDPMYFLKRAADQDTSPDKVDLGVGIYRNESGLYGQLGSVAKAKIVLAENDPGHDYEIRIGNQRFLNHAARLLFGQECELLQSGRIASAQTISGTGACHLAALALSQSISPRPQVFVGTPTWGNYKPMFELVGLKVIEYPYFDFQTRTIDFSSIITAALNVPPRSVFILQACCHNPTGADPTRDQWKELGAVLARNSHFVLFDIAYHGLGNGLDEDAYAIRHFATLGLDMFVCQSFSKNFALYGERCGALHAVCSSRDIAAVVQDRLRCLIRWEFSFAPAYGGRLATIVLDSDELTVDWVEDLSEIQHRLKALRKQLHHRLAQVLKTPGNWDHILRENGLFSYLSLNPKQCQTLIDQHHIYLPPNGRINISGLSQSNISYDAFIPHFKPEVFVLKYLGIVIFVFNFVWWKVSKKTTWWSASDVDLSTGRREWEETERPEEVHWEGGLWKNVLRKFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVP5</accession>
    <name>S0DVP5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427568.1">
        <property type="nucleotide sequence ID" value="XM_023574159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVP5"/>
    <dbReference type="STRING" id="1279085.S0DVP5"/>
    <dbReference type="GeneID" id="35395912"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02430"/>
    <dbReference type="HOGENOM" id="CLU_007785_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="417"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="857" mass="96879" checksum="361729B88F98A34D" modified="2013-09-18" version="1">MSARSAYARKKTTQAKNKDPVIHGRAQSVATSSSGEELFTDHSIPPNIPTPIAARFPHQLPPNVSIPMGSRGGRSMMSPDWNRDAYTSNQYAEEWVHNKPRRATVPDEYGTIERSGLRTMLDKRSDDVRKTIAKTFAFRKKEKEEEPIDQDSNGSRPSVETLQPTVMPSPSPNESSGWDSQSVARTDTTLTSTSSYATSQSQMPLTPTSQLSFGLPPVGPPPTTKLPPIPQVPTAPPPQIRRWCGGGRPITKWNKLRKDPELWDPNGDVLIYLGKKGQSLPSMRVSSHIIEAINSRHLISLLDEGLIDGYTHSPTSPNTESYGRKLGQEFRNSPLTPPASGRTSIGDMGGQVLYEMHFPPPQNMKTIDQLRHQLTTRNFFAMLLNASMVGLSLHEALSDLHVRLDSYMPPNNDNVGQLVRYLYNRDLDDVRNNPALAVSLLIWSEEPDVRWEEGWRECFAHCVGMFDLVQKYKDFKQINTNTRKLMEMASHEMQYRVQAAEERLAGFRYQDIWAFTPSTGSEMRAIERLKDMLLRHFEQEYGSWPPSQSDTRSGRSVGSSRPETWLTRTLAVKLQKDFGELYDCMVDRDIVWGSLEIQFGSRLMMMSKSKRRAIDADTREMHMTDMLIDFDNKHRFPHIPHPFPLLPESTSAAGSFRRGITKTRGDQMSALEERIRLAYTENTGFDEPEIKLADAFERFEKTDDIGDLDPATARRSRWILIYGILQSLASVSVDDEKVQYNDKVDYHLCPRLEGAKIPPWKRGMSDGVGQGAHERSYCWVAETERVTESDEYGDDVDMSLINDFPIQLNSPGAAEDRNTASGGSLGTGFISPRVRERMRRNRENESPVTTDYGCTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWI7</accession>
    <name>S0DWI7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_12996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17" evidence="4"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428911.1">
        <property type="nucleotide sequence ID" value="XM_023575630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWI7"/>
    <dbReference type="STRING" id="1279085.S0DWI7"/>
    <dbReference type="GeneID" id="35406452"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12996"/>
    <dbReference type="HOGENOM" id="CLU_036089_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002647">
        <property type="entry name" value="PRK02318.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002652">
        <property type="entry name" value="PRK02318.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="206"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT66830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="391" mass="43630" checksum="09232EE516AD35E5" modified="2013-09-18" version="1">MGKTAVHFGAGNIGRGFVACFLHNSGYDVVFADVNDSIVNQLNNTPSYRVIEVGSEATVENTITNYKAINSRTHEEDLIETIRTAEIVTCSVGPNILKFIAPVIAKGIDRRSTEESPLHVIACENAIGATDTLAEHIKNNTDASRLEDHHLRARYANSAIDRIVPAQDPDAGLDVTLEKFFEWVVDRTPFEDVGIPDIKGINWVDNLEPFIERKLFTVNTGHATAAYHGYNRRKRTVYDALQDKDIMAEVRGALMETKNLIVSKHAIDEEAQAAYVEKIIKRIGNPHLEDAVERVGRAPLRKLSRKERFIGPAAELAENDQPIKYLLDAIEMAFRFQDVPDDEESKQLAEIMSENGPEDVVKQVCGIQDNEKIFPQLVNVVQRVQADSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWU9</accession>
    <name>S0DWU9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427044.1">
        <property type="nucleotide sequence ID" value="XM_023573023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWU9"/>
    <dbReference type="GeneID" id="35397249"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03768"/>
    <dbReference type="HOGENOM" id="CLU_657293_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="418" mass="47266" checksum="36F93DFC00E6A7B0" modified="2013-09-18" version="1">MGFFDSITNAFNKIAEVAASSVQQISDTAEHIRRKLEEETRKAAESAAQRVLKEISGTAETMCRELEELIPSFDDKLQEVKAEITELASSAADDGVDITEAVNAAIEIAVQKVEAAKTAAIRAVNEFILQAQQKLFSLLRATFLTTNLANIGAKLLDNGISFILQQIKGLVQTLVKKVGEVLGPIWGFMKRIWKLLFGEPPEQCELAMQWIEERMYRTQRQMIYKRSAAPISAVIRQNKFFELLPPDEDSWKTTLLDYLARRSSPPGWRECCDRIKPVVGSANPKPGSMIQLTWDDQFTDELKGQQRTQISVIYFRWKTEEFRKVSSGFIGILAMVSAVDGFARPDEPPPFIKTQHEEPLHIDAVAMKKIYNEIKPHLRLLSANTEQDSSRFTGPKKVVSRQLMFRDDDGVWRTSNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX11</accession>
    <name>S0DX11_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429081.1">
        <property type="nucleotide sequence ID" value="XM_023575830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX11"/>
    <dbReference type="STRING" id="1279085.S0DX11"/>
    <dbReference type="GeneID" id="35406631"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13177"/>
    <dbReference type="HOGENOM" id="CLU_462340_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="537" mass="60498" checksum="1A0837465B3B1637" modified="2013-09-18" version="1">MSATQRKSNEAKVPKTVEPGPGPTTGSLAASYPLRPAASRQRTYPQQEEEEQDEDHATLYRYTNHDLSQQHLSTLSVREKLRKGIAMGFANNLAHTNATQDALQQGSQGSPGPQPMDTMTISGTMTKMDMHYHMMPDLSRLHSKGVDNRKVAEMVNHELINNAPGATGRAEFLRQRSQHIKAREVPVRVASERLHVITGSANNNRYAPFPILDLHPERLMRVEPFPNKNDSSLVVPLNSEGLMAWLEWACRRFGYWELELDSLHFKHDMVRNKMLKRSVSLGTHSPVSAEIADSVDALKLDARKGSITLYEANVTCGSPLQQQRWTWFKIVKPLLDIKGPVPQKYRTGDATMVFAIPTSKIKKIKEEWDPPLPVPQAKSQEPSQQDASAQLGDFGRLNLESYTQEATRQLALEWRYSENGIPTFAVTPHPWFMKKFPPDFLWIEDAPIYSADESWWDRLGEKAISDQDHWHYVQALMSGDICLVEARSKKGGKWIKVAPQVLKGNTGRTSTSYPGVGNCQSKTALAASRLRNEIQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX18</accession>
    <name>S0DX18_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429091.1">
        <property type="nucleotide sequence ID" value="XM_023575841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX18"/>
    <dbReference type="STRING" id="1279085.S0DX18"/>
    <dbReference type="GeneID" id="35406641"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13187"/>
    <dbReference type="HOGENOM" id="CLU_026929_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021216">
        <property type="entry name" value="DUF2722"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10846">
        <property type="entry name" value="DUF2722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="495" mass="54057" checksum="87320BA9BDC11ADD" modified="2013-09-18" version="1">MLTVKQPPTYGYKSVHDLPTPPSTSRPSPPLIYREPASNSLPIAYRGHSPPSQPMSAPHRGLPPPAAMTLPPQQPPVAGAPPSTHLPPHPPPPPPPQPSLGPPGHQQRDSWGQLPAPPQQWQGAEESMRHWLQARAEEDKRKQEEERTRQESLRLEQRKVEMDMLRTSLQAGIPPPMVPLVFAGMGSGGVAPQAALEWAQQFMPPGQAPPRAQIMPAQWPVSPEHQREPQTLSHTHAQHPGIPSASTPAAGYAYPASPSRPRGQTVSGAIGRPMGISTLPSINTNVPQPAHVPPPMHSHQHPHMQQQQQQEAQSSPSIYFHHWQPPTSQASGSSNRPGSPSESARQQGDHAPSPTRSEQRHRSPPPLSQSSSSSAAFRGSRRGHSRQRSDMSPFRVVGPGRSRRESFGGPLRRMSPIRASTPMPSQERPGSENKQSVSAILSEEPPPSTRYPGPRRLSEERESRYKQPSPGDLKPHRSIEETSKSREDSGDRQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXJ0</accession>
    <name>S0DXJ0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to 2`-O-ribosyl phosphate transferase RIT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429251.1">
        <property type="nucleotide sequence ID" value="XM_023576038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXJ0"/>
    <dbReference type="STRING" id="1279085.S0DXJ0"/>
    <dbReference type="GeneID" id="35406815"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13361"/>
    <dbReference type="HOGENOM" id="CLU_027654_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="336"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="453" mass="50159" checksum="66CFDC0F46F0DEEF" modified="2013-09-18" version="1">MPEPRFSDLILPQNEQLSMSQLMASFKRTTLTIHNRLTSIQTDADFVDAVSQAYSPRPLVANERCGSWYIPPERKGASAYFKSTDGHERAWKFSTRRLNLHLVDLIENNDGIIIVDSTRRGKRMPDALSSTIPIWCTVLNLTLLPSNPSSANLYLPVHLPATTHSQICALIPGFVASFKALNLNLPTCLTKPLRPFWVTPDSSLPSVQDTSSIFDDFRPVICCTASRRVVGSEMDEGGYIQGAADDTEMWAHDLTAPLFWKNIDELLKTPEAELPDLISRLVGDHAAGKKDEGIQIKLTPNLSVCPLPLPANPLECRIVITQDTAPKDSWIKSKTYMQAGLGKNKLASRNLRTSLPEICDFAAKYLALATEPDQQRIVVACESGRDLSVGVALAISCYLFDDDGNIRKSTEDASFTKTFIKSRLGVIMTAYPSANPSRATLQSVNSFLMDWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXV7</accession>
    <name>S0DXV7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to selenoprotein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428298.1">
        <property type="nucleotide sequence ID" value="XM_023575050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXV7"/>
    <dbReference type="GeneID" id="35396709"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03227"/>
    <dbReference type="HOGENOM" id="CLU_068510_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="132" mass="14685" checksum="D27443CD843C8459" modified="2013-09-18" version="1">MTSQASTQTPLPRVSIQFCTQCKWMLRAAYYAQELLSTFSTGLGEVALQPSTGGTFIVTITHQAPGADISSTETLWDRREDGGFPETKELKRRVRDVIEPGRDLGHVDRDHGKKEEAAKDKPAETEKCEDCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXY9</accession>
    <name>S0DXY9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_13634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429505.1">
        <property type="nucleotide sequence ID" value="XM_023576342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXY9"/>
    <dbReference type="STRING" id="1279085.S0DXY9"/>
    <dbReference type="GeneID" id="35407088"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13634"/>
    <dbReference type="HOGENOM" id="CLU_057411_1_1_1"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.10:FF:000004">
        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="9">
        <location>
            <begin position="147"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT67424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="246" mass="27358" checksum="B325FC8104D231C1" modified="2013-09-18" version="1">MRVLPRSALRTSRLTQSLARRSFHSYDHPPPPGAFGDAEKSILAAAYKHVPEHGFSQKALGCGARDAGYLDISASVIPDSAFGLIRYHLVTQREALAARSQELFPDLNQPGISARVEELTWERLLGNKLVLDRWQEALAIMAQPSYIPESVKELAKLSDEIWFLAGDKAVDPSWYTKRATLSMIYSTSELFMTNDRSPDFVETRQFLQRRLGEVKSIGGMVGSFGQWAGYTLSAGVNILRSKGVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY89</accession>
    <name>S0DY89_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12964</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429590.1">
        <property type="nucleotide sequence ID" value="XM_023575593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY89"/>
    <dbReference type="STRING" id="1279085.S0DY89"/>
    <dbReference type="GeneID" id="35406420"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12964"/>
    <dbReference type="HOGENOM" id="CLU_008828_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="703" mass="78499" checksum="EBB53AC34D36E988" modified="2013-09-18" version="1">MSEEHPVLKPKKRNSADAESVGDTPAPRSKRGKYTSVACDDCKKKKLKCIPSEDNACERCIAGGLTCTFATSSQATKEKPDDNQNIQALNHQLSELRQQMSDLVGVVRELKDQNQNQHQTLPHDASTASSHNIVTHSPASTHRGEMPKQPQFVGPTRSAFGILVSERSLNRMGVPKFDSMPPSGAQSPIEPALDSINDLSFWHCCTASDITKYLVNFQEEVESVYPFIDIAEYIAQSKEILQAIRGGGFEDEGRVSSKDIDIAKVAISTGILLEEPSKLELATAIVDSVQTNVSSILSPQVDLKEVQLLAMLSIYYFHAGEELLAWRSIGIAARQALEMGLHRKRSLLDNFKDTDSRRLATRVFWCVYVLDRRWSFGTSLSFALVDKDVDPELPKPDEEYLYLQCMVGYGQLCSKIWEAIPPFGSASQTIPDDTAAILDLKTQDWLDSIPPHLRLRHPRLGLAPRAQPRLPHRLRALLYLRGNYARILIYRHHLMSTASIASNPQNAWLVVDIAQDTIQVLVHLHATTDIYKRQQNVFNYFLLSALAVIFLAVCHAPEIFSVPCKRTFSDGVELVRGLSRHNIVSKRLWKSIRGMIPRMNTFGFPQNGEDGEPRKDDETGAANEQTVPQVEVNAEEHVPMAMPENEAFSFGDMMFGDADVANSVPDMFQMSESLLNLFNAFGEGQQFLQPVPSTFSEEGEIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYM1</accession>
    <name>S0DYM1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to dehydrogenases and related proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429732.1">
        <property type="nucleotide sequence ID" value="XM_023576574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYM1"/>
    <dbReference type="STRING" id="1279085.S0DYM1"/>
    <dbReference type="GeneID" id="35408000"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14619"/>
    <dbReference type="HOGENOM" id="CLU_023194_4_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="543" mass="60056" checksum="5F5F65219176C47D" modified="2013-09-18" version="1">MAPHAEQDESAHSITRLPPPERPAFSASPPRLLIIGAGNRGKAYAEAVKSSSNGIIVGVVEPIAQKRRHLGRKYIWGTREPTPGEEFRDWPEFVRWELSRRQAVASGSTDVPEGVDAVFICVQDGMHKDVVLGLAPLKLHIMCEKPLAPNLEDCMAIYKSLMPDASGSSEKLFAIGHVLRYSPHNVMMRKLLLEDKVIGDIMAVNHTEPVGWYHFTHSYVRGNWRNEKAAAPSLLAKSCHDIDILYWILAAPPPGSNKPTHVPKDISSSGSLQYFRKERKPVEAGNATNCLSCAYEPSCQFSAKRIYTGADLKSQQQEHFCTVVAPEIEDCIPNGGPEAAKQAIISKLAEDYSEDTPADEVSKRNTFGRCVYECDNDVCDNQVVTLSWDADPIAAPGETPLQALSGRGSKTATLHMVAFTEKICTRFTHIYGVHGEMYADSSSITVTDFRTCKKTVHYPHIPEGGGHGDGDEGLTRQFVLAVDRVKNHGEKVSTAQREYIKCNLRDVIMSHSMVFAAEEARKGKKVIDFPEWFEKEVMIKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ85</accession>
    <name>S0DZ85_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429942.1">
        <property type="nucleotide sequence ID" value="XM_023576579.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DZ85"/>
    <dbReference type="GeneID" id="35408005"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14624"/>
    <dbReference type="HOGENOM" id="CLU_001887_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485083" evidence="6">
        <location>
            <begin position="22"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1113"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1212"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1247"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1280"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1347"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="748"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1385"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1388"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1398"/>
            <end position="1443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1495" mass="168118" checksum="F633232BAE98431E" modified="2013-09-18" version="1">MLHFGYRLFLLLALLPVPTWADSGDDFSNNLFSDLAPLLALFGERVTMQFLSQSMGWADCIILAVAPLGIITTIVSAIRVDGPAWLKAIIGRSRENLSAAEMELMSSTSQETCELWNERDVVRCQGKAPVTEFICLAPPKGDGVIKRIRFLTLSEAIDQKLVQKQCERKVNIFNVIALYKGSHTEPQPSEISSHSSEGGKRYLWDAFRSRRKSRDVEVPTPILLESRTSEAQAEPSLAYELIVLRNTTTHAPNISLNRYHKVGRGHLYMVAIFGILLQLGVLVYFGSITYYPTLKFKKDDKEVLGYGFPFAAGGTLVLILGMLLCAHVVDRSTTEERYEPAQGREMRMIWLQQKQIRCPQVIVTSQRDSTTKSNRGRDPESSAVNNADSTSSQSEETENEISSSDSESGPAFNLTVIATAICLAGFIIQFIGLRAMHWSASVGQLIAVIIMTILRALVRVGFIAPIEYFKLRDKFELDGLALALGDPKLGPDSGPVDEEHRFDFGLSQGRTWKVVLKEDQVSQITDGSAVSLLSSNGDMGAPAQSNNPKPGGLSVERQDNEAQEILDIRKHLAHLAGWRGPASKEANSLAEAIEVTMNTLCPRETAEPRTWSWTIQIDVRAKDEDPKGFPISLHLSHQKGQWKARVDELDAVLSLWLASIDRERELASTTSKEEEIDDDDEWYRKRSSQTRGGLVLLGEHTESLKQAFEWWLPADAPKPLEIEESEIKEQYDETWRIVGTKFREGYYMPPLTESSEKEEEREQANSSDSDELDDEDDDDGDDDDDSSDEISAPSTLGRAIFFYIESNDTLEQLFARHIFHAFVWAAASQMKAPIDQHSEMEVVGTVIPGEWNNIRFRGTSLARLVGSIRSSGLMDLNQAFITLIPPLHAYARLGELDCVIEAVLGQALQHEKALNWEAAYESYIALLDLSSQFREDSFAFRRTVAIAVEYMRTLKLLPKVPESGEDQFYVTESIYESLSLRLNSRTYQQIRNDLGTLYERQRRAKGSPCNDGEQREIINCGFTRLHDMTAQNQFDHEFDKRERKRMRHRPLKPIETRVAIEDITDKLQKYVRAQDILGWTPLHYAAAWNDDEAPYWIDSLLARGADLDAPDIRGWTPLHYSLWNANHRAVRTLVEKGANTKIAGVDGITPLHCAAAKMTGRIINKLISHPRHRADQFATDNFGRMPIHLAAQEGNTRVIGTLLPSIHEKDQYGGTAFHLAAFSGKLKTLSKIIECGADANEPFGSYYDSTTLHWAAEHSKTGLAKILLHLGANVNARDCAKFTALHCACMHNRLEMVEILMGSGADVNAEDRCHHTPLWHAAYSGNTECVGRLLEAENFDINAPVQTGESPLYGAIKRGRGDIVRMLVEKGAKISQQMVDFAADLYEPGERKDKEDVEKMDEDKEEEEDENDKDHDDHDDDEDEEGDKEEDKEEEDEDEEEVHVEEGNKRLGLKTEDFGKYIRAAFSLQNAFCKHVQEDREKVILSELIRRLCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0E136</accession>
    <name>S0E136_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Probable subtilisin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_03429</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428484.1">
        <property type="nucleotide sequence ID" value="XM_023575276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E136"/>
    <dbReference type="STRING" id="1279085.S0E136"/>
    <dbReference type="GeneID" id="35396911"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03429"/>
    <dbReference type="HOGENOM" id="CLU_003559_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02124">
        <property type="entry name" value="PA_PoS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 9 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484727" evidence="11">
        <location>
            <begin position="18"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="156"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="13">
        <location>
            <begin position="382"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="14">
        <location>
            <begin position="615"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT66403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="882" mass="94402" checksum="CB50D3714BBCCD99" modified="2013-09-18" version="1">MVRLSIVAALYAAVANAVDFDKIAVGKGHSRLPGAYIFEFEENHDCADFFAKASARGRTRMQYNYKLFKGASIQFTDIDNAEDLASEMALLPGIKQKWPVQTFSIPKPEVHWTGTPGMEYKSIQKRGFEERDSVNDTFSPHVMTQIDKLRAEGVTGKGLKVALVDSGVDYKHPALGGCFGKDCLVSFGTDLVGDAYDGLNHAKPDDDPMDCAGHGTHVAGILAAQKNAMGFTGAAPGVKIGAYRAFGCNGEAGNDVLIAAFNQAFEDGADIISASIGGPSGWSEEPWAVAVSRIVEQGVPCVLAAGNAGAMGMFYASTAANGKKVTAVGSFDNTKSLALLNASKYSIGGGPEHEFGHLSGKPSAWKGVKLPLWALNYDTSVADDGCDEWPKNTPDLSRYIVLLRRGSCTFDAKAANAVKAGAKYIIFYSNKEDLAPFDVSSVAGIKAASIVSPEQGADWIASLKAKKKITLSMSDGSDGNVILEQKHNNVTAGAASTFSSWGPTWEMDVKPQFGAPGGKILSTYPRSMGSYAVLSGTSMASPLVAGIVALIAEARGTRDPALIENLLSASANPQLFNDGKTFYEFLAPVPQQGGGIVQAHDAAYAKVLLSRSSLSFNDTDHFAESLNFTVKNTGKKQIDLQISHVPAVTMFTLVENYIYPDEFPNDFAKEHASLKFSESKITIDAGESIVIEVLATPPKGLNATRLPVWSGYVTINGTDGTSLSLPYQGLTGSLHDSMVLGPKDTWIANSTDQNRFPVADNTTWTLPKPGTANNLTDTLPGLTWFLALGSAKLHAEIMPVTTEKPTSSKKPRVIGEPVDFPLLWNAMGTNSQAFTGELADGTFAPAGQYVVRYRALRIFGDEKKKEDWDEAYSPVFTIRYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1E0</accession>
    <name>S0E1E0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to myo-inositol transport protein ITR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_13713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429578.1">
        <property type="nucleotide sequence ID" value="XM_023576429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1E0"/>
    <dbReference type="STRING" id="1279085.S0E1E0"/>
    <dbReference type="GeneID" id="35407167"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13713"/>
    <dbReference type="HOGENOM" id="CLU_001265_43_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="117"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT67497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="697" mass="77411" checksum="962B0C82892F4151" modified="2013-09-18" version="1">MTERDNRELQKPSLKKRVEAWIEKQIHTRDEFGNSLAGVSEPVLRKGIDTLCRELPSLERDEVERAAEVAKNGNYYYRLSKGLITNLSPVVELTQDEKESLVAERERLFSQRGMLIIICTVSLAAFLQGHVQSSINAMSLFVETIGIDIQRQDDTQSNGADSTAQWQLGGMNAIPFLTAAFPGAPLSLPVNYCLGRRGALGLSALLIIASSIGSAFAVTWQQILGARIVGGVAMGIKAVSAPILASETAVGYWRGSTILAWQLWVACGIMIGFVINFVIAAATNTLDGQPNAGLNERGGRYHALQWIAAAPVVPSILLFIAVCFCYESPRFYMRPGTPNYNLDRAFRNLLQVRPTRLQATRDLFQIWWSTRDGEVHRDRREKNRHEMAHHAEHQNGVNSKNEDRTNRTPTSGLTYASLIILVSRLSVDQFKPLFTRRRLRNALWSSCVVALSQQLCGINVFAFYSNGMFSDYGVKTSMGYSFGFGGVNFFFGMLAMRSIDIIGRRRWLLLTLPLMGMFLMAATISYAVAPQVDSGDQPKPKADTGGSIAGIIFIYLFAAAYSPGLGPIPFTLASESFPLKNREAGASVAISINLFFAGLLTIILPRINAVFEMAGTLGFFAGLNIVAFVLIFFFVEETKQLTLEELDTVFNNPKSRFAHYQLTKRLPFLSKRYLLWKKDAERPLAYDEWAVEDGQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1L5</accession>
    <name>S0E1L5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429633.1">
        <property type="nucleotide sequence ID" value="XM_023575588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1L5"/>
    <dbReference type="GeneID" id="35406415"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12959"/>
    <dbReference type="HOGENOM" id="CLU_032153_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="429" mass="48315" checksum="BC8FCEBEBA579437" modified="2013-09-18" version="1">MNTKGELINVKGNTLDRFVLHSTLLRLIDPVRGKPTRNTLDENPDGGFSGVWQLQQKFLDSFALICSTSSSGAETATAVCLEIHDQIGNVLRLARNHGLTPEDLAGLKRVLQVLQEVSRREKPSSQAETEVLQLVAELDKDRILPIAERIEKRGIRQFLQKTQSGAQYRQLQSEKLKIWLESCPFTASTSRIQSWTCAAIVKLINWASEARWQYAEQLRTLLELDESKSQAWLDNLHKVARYHSAIKSMIKFAVKEPGIFVNIGILPINAPRPCPFKFPYGEAPLLAIVQTLLGKDTNSAMEKLEKHLGTQDVEPKLRKACPPKLTLHAEMQIVVFYEGKPGLVPHLRLIGTSKKACFLCDQYLRHHPLRLQASACHQKIYPSWMPPPYYRVPGTSAQLPFIKLSGDIEKLTRRELKSALTIPPPATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3A6</accession>
    <name>S0E3A6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to microtubule-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431371.1">
        <property type="nucleotide sequence ID" value="XM_023578157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3A6"/>
    <dbReference type="STRING" id="1279085.S0E3A6"/>
    <dbReference type="GeneID" id="35401334"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07857"/>
    <dbReference type="HOGENOM" id="CLU_013892_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="772" mass="87497" checksum="609010AAF9EE1F34" modified="2013-09-18" version="1">MVDTSYLAQQVNNSIAQLHGLFDEIGVPDHDREARESELFSALSEALNSQVRLVNSEKKEMVDEAKKIITMIHQMEASLDDSKRRRDYEDDDDLTITYPLTQCLQQLKEKHIQISRLHKERFDQVKKLVMALESYSSHLEPTFVQIPLPPTGPNQSIPPNFDLSSTYVDKLDNEFTRVYEEYSRRIATVQALAEQTIGLWAELGIPQAQQDGAIVKYYRDAPEQLGLHEEDISRLRSKRDRLSDEKKNREKKLKELRSSVEALWIKLGVDESETKPFLNANRGCGVRQINEFEDELARLNELKRQNLHLFVEDSRIKLQELWDALYFCEDEMLEFTPAFSDVYSDALLEAHEREIARLEALKEQRAPTLALIDRHKSLIQERDDLAASSQDASRLMARGQKGEKRDPGKLLREEKMRKRIAKELPKITADLRKILSKWEDEYGRPFLVYGESYLDEIEASDGPKKGALPPRSKTPAGPPPSTIKPPKSVPNRAATKSAPPRSMTKTPTAGMPPKRPGHQATGSISSIPGSPARSPSRIPARVPLSNMKHGNNSPERPRAESRADTFRPGPPLMRAPPPKMRDLMARGDLEAPMNPYKSMGLNSSIVRHVEPEDVYDDRPRTARSNSNNSQYSSHPSNNSQFSSHPSNNSQYYSEESFHDPYSTIRSQGYRPMAPPRQISGNSMASTNISGSENWETYDDNSEPELDVSDAYYAKLRATRNKRFSPEPGRPTSSQSKRIRGIPPTASYNGPVMIDQDGNRIISGSEWTDEDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4J5</accession>
    <name>S0E4J5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable carnitine transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_14571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429704.1">
        <property type="nucleotide sequence ID" value="XM_023576520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4J5"/>
    <dbReference type="GeneID" id="35407952"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14571"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
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        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF6">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="38"/>
            <end position="507"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT67623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="562" mass="61312" checksum="43F2F9580D597A39" modified="2013-09-18" version="1">MSSDSEKASKRAESPSPIAESDGGNADGLHRRLNNRQVQLLSIGGTVGTGLFIGIGAGLAKGGPGSLLVCTALYAMVLGLTNNSIAEMNTYMPVSGGFIRLAGHWVDDALGFMVGWNFFFYEALLIPFEIVALNLVVSFWSDTVTDAGPTAGFIIAVIIAYGVLNLLAVGVFGEAEFWLALGKVLLIFILFMFTFVTMVGGNPQGDAYGFRYWSNVHDAFATFRTEGDLGRLEGFMGALASAAFFVVGPDYISMVAAESKHPSRYVKTAFKTVYFRFGLFFIGAALTCGIVLSHTDETLVEVHLGTGSGHGTAAASPWVIAMSNLGIEGLPHLVNALLFTTIFSAGNTYTYCATRSLYSLALDGRAPAFLRKTTKNGIPIYCFAVTMVFPLLAFLQLDSSSAEALTILLALITGGGIVDYITMNITFLFYYRACKAQGIDRKKMPYFGYFQPYCAWIALILHTVVCYTYGYTSLAPFNAKNFFSNYTMQIIAPFMYLGWKLFKRTKIVSAKECDLVWERPVIDAYEERAMIVDPPTGFWEEIIGLVGIKKNKKKKNAAEVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4V9</accession>
    <name>S0E4V9_GIBF5</name>
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        <submittedName>
            <fullName evidence="2">Related to trans-aconitate 3-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT67683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023576624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4V9"/>
    <dbReference type="STRING" id="1279085.S0E4V9"/>
    <dbReference type="GeneID" id="35408045"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14665"/>
    <dbReference type="HOGENOM" id="CLU_049344_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF10">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="53"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="310" mass="34197" checksum="478885A08D1F2444" modified="2013-09-18" version="1">MSQTQQPSDPTFRAYSAQQGATYAEHRRNYNPKLYDTIINFHKEGSGQFNTLIDVGCGPGTATHSLAPHFKAAYGLDPSEGMISTARSITTLENVKFAVSSAESLGSELADPIPDGSVDIITAATCAHWFDMPRFWEQAAKTLRPGGTVALWTSAGVRVDPSMPAHEAVQEVIDDLDNLVQDYMLPGNLLSRDLYRDLPLPWTIDPPLSVFDRGSFMRKEWCTGPDSETMFFQHSPPVSLDMVEMVLGTASPVTRWREAHPEAVGTENDVVRQIRRRIEKILGDAGVEKGKEMLTGDMTGVLLLVRKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5A1</accession>
    <name>S0E5A1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to acetyl-CoA transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431960.1">
        <property type="nucleotide sequence ID" value="XM_023579054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5A1"/>
    <dbReference type="STRING" id="1279085.S0E5A1"/>
    <dbReference type="GeneID" id="35399280"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05801"/>
    <dbReference type="HOGENOM" id="CLU_020502_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="579" mass="64281" checksum="16B976603D20079F" modified="2013-09-18" version="1">MTARARRPQNKPARPPLTIKTEAEDANGHGHLNGNGKMSSGVEMRRKSANPDADNVAANFIKSESFSLDDPIPKTPSLNNHGFFDLPRQDQRNFLLLVLLYFLQGIPMGLATGSVPFLLKNHMSYSEIGIFSLASYPYSLKLFWSPFVDAVWSPKIGRRKTWIVPIQFLSGFGMLWLGSHVEDMMASAGKPGGMTAFSFMLWWFFLVLMCATQDIAVDGWALTLLTPGNVSYASTAQTVGLTAGHFMSYTVFLAFNAADFANKWFRAVPSDDGLLSLGGYLKFWGWSYIIVTVGLGLLKKEDKSQNEDGVWDVYRIMWGILKLKNVQTIIIVHLIAKIGFQANDGVTNLKLLDKGFGKDNMALTVLIDFPFEIGLGYYAGMWSQKYTPMRLWCWGFVGRLVAALSAQFVVAIFPDEGVTSWYLLVVIAEHLFSTFTNTIMFVAVSAFHARVSDPVIGGTYMTLLATVCNLGGTFPRYFVLRLVDSFTVATCEPGKSDATTIKGTLIKDAFSCAVQSEKERCEAGGGTCHMIHDGYYTVNILCVLFGAATFFWYIKPKVLHLQSLPLRAWRLAPGNENKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5Y9</accession>
    <name>S0E5Y9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431212.1">
        <property type="nucleotide sequence ID" value="XM_023578396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5Y9"/>
    <dbReference type="STRING" id="1279085.S0E5Y9"/>
    <dbReference type="GeneID" id="35407830"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14379"/>
    <dbReference type="HOGENOM" id="CLU_900281_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="310" mass="33486" checksum="36D5C33E6FCFD090" modified="2013-09-18" version="1">MTDTFTTTFPTTPNPTWTLPRFTPPPECLDTKSVWKLDTDCYSGTAQGLYRTTRTCDYLWLGYTDYPHTTGGLGHGLNGFCGPGWSHPATECPVGYTPAHTVDYTPDATTSREILCCLAAYDFEWRRPTLTDQSGSSATPYDRFCVASNLRPSRTSPLTLTAFDLSSASSLQTDTRVSTTIKFDPEKDLLLASAVTISYQINSGGTTCVPDCADPYTGGPWPRPEQTVTPAPPSPNDSGLVGLEKLAWVGIGFGIVAGLGIIACIGCCIHRRRKRKRIVAAEGPAANPGVEEGQNQMSVELQVSKGRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6P4</accession>
    <name>S0E6P4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432439.1">
        <property type="nucleotide sequence ID" value="XM_023579637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6P4"/>
    <dbReference type="STRING" id="1279085.S0E6P4"/>
    <dbReference type="GeneID" id="35399802"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06325"/>
    <dbReference type="HOGENOM" id="CLU_078580_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="267" mass="30360" checksum="C43584C3EA4B9C54" modified="2013-09-18" version="1">MPKEKNYNPVQAQRKADKAKALKKGKHERQERLNEKLSRKNPERIQKQIDDLKKITSSGGKLTRHEEQTLEGLEKELKAVKKAREALGDKAPTFSRGWNRDHDSGSRVLGKRRRGSNDATTSDDEVPDDVKSIPMPRDTPPPIPKEVMDKWYAERRARREAENPTRPDGEDKHQKKEVPVVEAKTVYEAKPVVRDLRKEAVSAFVPTAVKMKMNKGQGQGGLIEPEEADRLEQEGYLKTADRNAEARPDQGQSSRHVTMEDVEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E731</accession>
    <name>S0E731_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432725.1">
        <property type="nucleotide sequence ID" value="XM_023579982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E731"/>
    <dbReference type="STRING" id="1279085.S0E731"/>
    <dbReference type="GeneID" id="35400112"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06635"/>
    <dbReference type="HOGENOM" id="CLU_029945_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="524" mass="60250" checksum="1F4EAB2112D6C19E" modified="2013-09-18" version="1">MSWKRSSLADTGFFYDEDLRDQRIDPFPTHVKSLEQAMLDFTCQDFDPTTKQDLTIQNEAKRLAKGGFKEDRWDDFYREYFLDPLMARASITGKRPRISSRCQYYYDSIVFNTDALWTTFNKRSEEDRPFKAPKPDLVFLFPMYHPDSQIPTVTRHGAREWHKESTPSLVEPFLWSTLRELNQHGLKPTPFNVLDKKTPLEADLSSYPWLVVEYKRAKGTERSTTASSRRLEEVVYCQAANAGGCAVKLNQNAARFAIQLAGNAQVPPVPTITTVGPQVKVWITFYAQDLMAYRFKDKYSQQYQGYKEGYMMQCIWAGDITVANDILKFRLILENTYTWAIRVLKPLVATYIDQWRFAYATDNSSMAGMTRARQQDRLELTRNTVRSIYCALDPELNPRAGKDWHRGVSMRLRELCETFVQDVDRMIDEELKSSRRSTRGASKEVRGFKRSVQLNSDGPRSIEHEGLQPRQSESPDYASMALPSAPRSMSPSETSGAVEVVSSYLKASMAIWNSWGTQETAKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E797</accession>
    <name>S0E797_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable phenylacetyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431692.1">
        <property type="nucleotide sequence ID" value="XM_023578731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E797"/>
    <dbReference type="STRING" id="1279085.S0E797"/>
    <dbReference type="GeneID" id="35398991"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05512"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="474"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="574" mass="62848" checksum="FE564E01DC524947" modified="2013-09-18" version="1">MAFYPPSWVPNLPDIPDSISVADFINTEKAGRKSFDKSKRPYTCGVTGTSRTAEEVAQRVDLLARGLAKNVGFDPNDGTAWDRVVAIYALNTIDYIPVTHAIHRVDGIVTPASSAHSASELEHQLRSSGAKALFTCAPLLSTALKAASAVGIPETHIFLLPLPETPSKGSFKTIEDLIAEGKTLPPLELPAWTPGQGKRQVAYLCYSSGTSGLPKAVMISHYNVIACTLMIHTFESITRAQDNIDTQVALGLLPFSHIYGLVVIAHIAQYRGDEIIVLQRFQLDQLLAAIEKFRIEQLSVVPPIIVQILSNQDKCQKYNLDSVRLVFSGAAPLGGETIQKLLELYPKWRISQGYGLTEASPSVFHTSEADPVLGSSGSLLPGAKVKIIDQHGSEVTSYETPGELYVQAPNVVLGYLHNEKANAETFVHRDDGRWLRTGDEVLVRKSPRGNDHFFIVDRIKELIKVKGHQVAPAELEAHLLDHPYVDDCAVIGIVDERAGEVPLAFIVKSKKTNGLKDEDVVRAVCEHVESHKARHKWLKGGVRVLDVIPKSPSGKILRRVLKAQIKAEKPVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7N7</accession>
    <name>S0E7N7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_07253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430548.1">
        <property type="nucleotide sequence ID" value="XM_023577485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7N7"/>
    <dbReference type="STRING" id="1279085.S0E7N7"/>
    <dbReference type="GeneID" id="35400730"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07253"/>
    <dbReference type="HOGENOM" id="CLU_102602_4_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT68468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="84" mass="9483" checksum="BA6052579E6EAE11" modified="2013-09-18" version="1">MSETYTTAEVGKHKDEANGFWLIVENDVYDVTKFIDEHPGGAKILKRWSGKNATKAFWKYHNEHVLAKYGKDLKIGAVGESAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7U9</accession>
    <name>S0E7U9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_05776</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431937.1">
        <property type="nucleotide sequence ID" value="XM_023579026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7U9"/>
    <dbReference type="STRING" id="1279085.S0E7U9"/>
    <dbReference type="GeneID" id="35399255"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05776"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="806"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="835"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="919"/>
            <end position="940"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="952"/>
            <end position="972"/>
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    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="49"/>
            <end position="340"/>
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    <feature type="domain" description="ABC transporter" evidence="11">
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            <begin position="375"/>
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            <begin position="1014"/>
            <end position="1255"/>
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    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00007577"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50929"/>
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    </evidence>
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            <dbReference type="EMBL" id="CCT69857.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
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    <sequence length="1262" mass="138401" checksum="AC4E6A27D744D149" modified="2013-09-18" version="1">MDADNEKKILVEDSTTTTTQKDEPEKQAELGDLWRVFRFADRLDWILNFTSLICSIASGATLPLMTIVFGQFTGRFSDYASGKIDPEGFQDEVNTFVLWFVYLFVGKFVLSYLATLTVTVSGIRTTRVLRQRFLEHLLRTEIWYFDTANVGSPATQMTTNVTRINQGIAEKLSLLIQGLAMFVSSFVVAIAVQWKLALITLTVVPLFFFIIGVGMTLDAPIEAKVQGSYSQANVFAQEVMASIRTVHAFWAQGRMILRYDDYLKEAHVHGKKKSFMYGVMSSSTYFCMYAGNALAFWQGFRMYQSGEIDSVGTVFTVVLSVLLASSSIGLLYPQVPALANGAAAASELFKIFDKPSSLDPFGDEGKAPENCHGHLEVENVSFSYPSRPDTNVLNNISLNIPAGKTTAIVGASGSGKSTIIGLLERWYLPTSGRFLLDGMDVSMLNVKWLRSQMALVQQEPVLFRGTVFENVAKGFTEAQKALSLDDQRKLVQEACEASYAHEFIQKLEQGYDTYLGERGGTLSGGQKQRVAIARSVVSNPKILLLDEATSALDPNAERIVQKALSRVSQERTTVVIAHRLSTIKDADNIVVVSAGQVVEQGNHEELLALNAHYARLIRAQNLTVSANDVQKDMGAKQDMVEVETDEEVARIMTAQTEKSMVLKDGDAKPKDRSILTSIFLILKEQKALLPHIIVAALACSIAAATWPGQAVLFSRLITAFSSSQPSASDANFYALMFFVIALGNLVAYFTIGYISNHVAQSISHQYRLELFSRMVVMDIDFFDRTENSSGALASTLSSVPTSLTELLGLNIYVVLVMAVNITASSILALAYGWKLALVMVFAGLPLLMGSGYFKIRLESRLHESNEARFRESASLASEAVSALRTVASLTAESDFIQAYSETLSSIVAQSVKSLSISMVAYAFSQSIEFLVMALGFWYGSRLISSGEYTSEQFFLIFMGVLFAGQAGAQLFANLGSLTRAKGAANYLFNLREEQPVVRETDENKDRGPDLGQPISVDNVHFKYKSRSTKVLHGLSMDINPSQFVAVCGPSGCGKSTLVSLLERYYDPTSGKICVGGQDIKDVSPRLYRNEMSMVQQEPVLYEGSVRENILMGLDGDIDDTSEERLNEAARQANILDFVSSLPEGFNTPCGARGTAFSGGQRQRIAIARALIRRPKLLLLDEATSALDTHSEQLVQEALEQTRKESGCSVIAVAHRLSTIRNADVIFVLVGGKVVEVGTHEELQAKGGVYADMCQAQSLDREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8C7</accession>
    <name>S0E8C7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_07545</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023577810.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="35401022"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07545"/>
    <dbReference type="HOGENOM" id="CLU_000690_1_0_1"/>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="914"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="1218"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="518"/>
            <end position="600"/>
        </location>
    </feature>
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            <begin position="1321"/>
            <end position="1406"/>
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    </feature>
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    </feature>
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            <begin position="1638"/>
            <end position="1779"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="27"/>
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    </feature>
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            <end position="125"/>
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            <begin position="164"/>
            <end position="195"/>
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    </feature>
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            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
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            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
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            <begin position="244"/>
            <end position="254"/>
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    </feature>
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            <begin position="1638"/>
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        <location>
            <begin position="1660"/>
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    </feature>
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        <location>
            <begin position="1736"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1759"/>
            <end position="1771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT68733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1825" mass="204907" checksum="BA63CEE4E13CE739" modified="2013-09-18" version="1">MTQHRPDGDVSPMDVSPRSVSPENPNLQPAPPSVSKSTSDTLLPPVGLKITALSNPPGSTKEIKPASNELASGHGKAPLTAIPRSTPASTKSLKDHGISDRDFGLAVDGDGQDNSQAPSRPSIQFTRPDGVDTPPTFMRGNSWEEPETPGKSRGASLMSKLKALTNNGGVSTPKSSTVAGPSSQGNQSNINSPTRPSRGVPGTLTEEDTDADADAEETADEGSPGDGKSKKKKQKRRMRRTKKATTPTPGTPRRFVSDIDVLDSFDQLVKRRASMPDTTVPDYGVSEGEGRDRLGMAFRRGNSWMTSAVRHHGEEIDEVESPGAVGRRTGHVRRITVFGGGGVSDGDAMTPRRPFFTSERASTFGAQKWKQVKNTLKLLRQKKEDRFDYYKSAELMAELRAGAPAVLMLASMIQRDEHGNKRIPVLLEQLKLRITDSSPMEDDDKDRHWLFTIELEYGSGPSRMSWTVTRTLRDIYNLHLRYKFAINNDKYMPGRMDLGGRPKQPKFPYSAFPYLRGARKKGEESDEEDQASIRGEEETAGEGTATEAAGDGIFSDPENPGGLPRRKSRNFLGMGPRRRSTGITDPGDMSNPEGPGMPAMDMATRRQRYVEKQRRILEKYLSEMIRWLMFRADSNRLCRFLELSALGVRLAAEGSYHGKECYLHIQPSKGLDFRRALTPAKVISRHSRKWFLVRQSYIVCVESPENMNIFDVYLVDSKFSISSKRSKVKAIGSAEKKAEIDLTVEAPPDKHHTMTLRSSERKVRLFSRNQSVMKQFEDSINQMLKQTPWYQNKRFDSFSPVRNHVFAQWLVDGRDYMWNVSRAINMARDVIYIHDWWLSPELYMRRPAAISQKWRLDRLLQKKAREGVKVFVIVYRNVEAAVPIDSEHTKSSLLNLHPNIFVQRSPNQFKKNQFFFAHHEKICIVDHDVAFVGGIDLCFGRWDCPQHPIVDDKPTGFEMSETPKDAEHCQLFPGKDYSNPRVQDFFRLNEPYEEMYDRSKVPRMPWHDVAMQVVGQPARDLTRHFVQRWNYLRRGRKPTRPLPFLLPPPDANVDELKELGLTGTCEVQILRSATTWSLGIEQTEHSIQNAYIKMIEESDHFVYMENQFFITSTEAYNTRIVNRIGDALVERIIRAHENDEDWRCVIVIPLMPGFQNTVDEQEGTSVRLILMCQYASICRGEQSIFGRLRTAGIEPEDYIAFYSLRQWGVMSNDVLVTEQLYIHAKTIIVDDRVALIGSANINERSMLGSRDSECAAIVRDTDMINSTMAGRPYQVGRFAHTLRLRLMREHLGLDVDEILEQERQAELDRQDFEKEMEDIYNEENGGPADSSKLSPKRPDHLRIPSINHDLDAAVEVEDDSSSSSGSSSDSNAEVDSTIINQSEDKVKHELDVTGYGPDRWKTAEKSGLDAGRDSVIINGREVLVSNIGNEGKGTLQSPKETQPHSPQPDNRYLDPGNHNDSLPPVPALNRRTTDQLGLPRPAQLPSLPISDDTDIGGPPLHIDPETGKPVNGIFHPMAADIHLAHIDKDCMVDPVNPNFIDEIWNRAAQNNTKLYRRVFRCMPDSEVSTWAEYREYTTYGERFRASMEGGRSRGEDSEFPPSSRHRGSTAGGAGVSAPGPEVMAKAVETEAEKAIGRMTEKLPLGHHEEDRIKIVIPGESQRDTDEKQAMKDGEAISSRPTTGLENDNGPDAHQHTEAPSPVYSPGDTPFPAFDGGSSGRYLDPQTGTKDRERRTTFSTLEKPSSRDTNAPPPGQFGSVKRRRRATTKNSRRGFSIDDMPSRGQAEELLNMVQGNIVQFPYDWLLTEEQNGNWGYQVDGVAPLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8E3</accession>
    <name>S0E8E3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_08801</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433230.1">
        <property type="nucleotide sequence ID" value="XM_023580457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8E3"/>
    <dbReference type="STRING" id="1279085.S0E8E3"/>
    <dbReference type="GeneID" id="35402277"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08801"/>
    <dbReference type="HOGENOM" id="CLU_039453_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="14">
        <location>
            <begin position="81"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT71151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="272" mass="30775" checksum="5D475DABE866F726" modified="2013-09-18" version="1">MGSQPEKENGRVDLRPEEVIGDLGFTPMVKVADPWTVDKVVKEIPGGAPTEDSSSPLPFFHMLERLKTTKREGWRRFGISRGESIADHMYRMSLISMFAPPSLAPKLDLPKCMKMCLIHDMAELLVGDITPVDGVPKPEKSRREAETMDFLTKNLLRNVAGGTTGEDIRAIWQEYEDSETLDSHFVHDVDKMELLLQMVEYEKRGEGKVDLGEFAYVATRMTLPEMKAWGQEVLKEREAFWGSKQHVHGEQGVSGGVTSERKGQQDNYYNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8L9</accession>
    <name>S0E8L9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="3 15">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 15">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 15">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_06066</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="3 15"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432201.1">
        <property type="nucleotide sequence ID" value="XM_023579349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8L9"/>
    <dbReference type="STRING" id="1279085.S0E8L9"/>
    <dbReference type="GeneID" id="35399543"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06066"/>
    <dbReference type="HOGENOM" id="CLU_020346_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070693">
        <property type="term" value="C:P-TEFb-cap methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 15 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="18">
        <location>
            <begin position="121"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="320"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT70122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="477" mass="54502" checksum="CCF926DA9D622FF5" modified="2013-09-18" version="1">MGRDSDRDDGDERNHRKRPANDEPQDDLPQPYNAKSLQPAKRRALSPSEQPRKLKRPGARARISEAEREAIRQRQLEREREAAAEEAAEAEQERIRNNSDLVRHHYNNVPERGRDWRTRDSKIKGLRVFNNWIKSCIIQRYSPDEDHTPGSREAGRSSGKDLLVLDMGCGKGGDLNKWQQAPQPIQLYVGLDPADVSIEQARDRYRTLGSRGGRGGRGGHRRPPPRLFDARFHVKDCFGESIENLDIIQQVGFDPSPMNRRGFDVVSMMFSMHYAFESEKNARNMLRNVAGALKKGGRFIGCIPNSDVLGERVRRFNEEAAAKRAAKQSEEKDGDGSTTPQQTEPEDGELEEGEEEPTAEWGNSIYRVRFPGKTPDDGVFRPAFGWKYNFFLDEAVEEVPEYVVPWEAFRALAEDYNLELQFHRTFPEIWEAEKDDRELGPLSERMGVRERGGGPLLVSDEEMEAASFYVGFCFYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8P6</accession>
    <name>S0E8P6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Synaptobrevin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_08671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433350.1">
        <property type="nucleotide sequence ID" value="XM_023580601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8P6"/>
    <dbReference type="STRING" id="1279085.S0E8P6"/>
    <dbReference type="GeneID" id="35402147"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08671"/>
    <dbReference type="HOGENOM" id="CLU_027976_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT71271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37701" checksum="27AD48E9EC3439EB" modified="2013-09-18" version="1">MARLSNSTVHPINRSAIDIASAELGTLLLRLQKTVLHTDSDRERRLRSSEFERARVASNLEYARSSLTKLEHDALGIKAPGRRAEVQSDLNRKRELLELLLDRLEDLRQVAIEEDEDDESTDGEDILSEIIPTPSDSMVDSISTGQPTESSGQDDDAESEPPKATTIPVTTATVPAPASTTPPDTSTTSQEHKQQPTQTTQNLRSRGAPSSPSPSAHSTARAALFVNRSKPSTPQTSTATAEALLDHQRAEQEALSESILQMASALKSSSQRFSTTLEADKDVVARAGEGMDKTEQSMEAAKGRMGMLKRMTEGKGYFGRLLLYAYIALLAVACILVVFVLPKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E943</accession>
    <name>S0E943_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to MTW1 Determining metaphase spindle length</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_07914</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431063.1">
        <property type="nucleotide sequence ID" value="XM_023578220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E943"/>
    <dbReference type="GeneID" id="35401391"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07914"/>
    <dbReference type="HOGENOM" id="CLU_046437_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT68983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="343" mass="37521" checksum="1022A10518DC3BE9" modified="2013-09-18" version="1">MASQQNSDYELLTEHFGYPPVSLLDDIINTVNVLADRALDSVERLLLSIPPQSLGFSSKHASKDGTPALPPDEAAKLEIEHGTHQLETLLNASIDKNFDLFELYTMRNILTVRPDDQPFMRLAHYEGLDFSGSEVPDRPTTESVTALRRRLHASQRLHTALESERARNDALLGKLRSVLGVVPGNVKAEEGQAQAPDGSAFGFLRDKASLQAAGADKPIATTTEFTLSQLQALRALSTSLRTLLPDLGPTDADTSMEDASSSSRTWRRERVEYVEGASRKYLETARGLELGDQGEVRDGEWQGEGRKITRSDVEGLEQVAAMLGQKSTTTDEASGEGEPMDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9I0</accession>
    <name>S0E9I0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432501.1">
        <property type="nucleotide sequence ID" value="XM_023579715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9I0"/>
    <dbReference type="GeneID" id="35399872"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06395"/>
    <dbReference type="HOGENOM" id="CLU_1372273_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="197" mass="22248" checksum="C7138636277C0B22" modified="2013-09-18" version="1">MSDQRDLSEDARVLAKIYSTQFYRRVDGLARNASGVVYDPSRGPAPPSPELKPFQPAPPRPDTPRPSGPPSIDIPGRAIVNENFQENVRRVLGDAYVNSWSSLGDMTMGCIDFVRGKKQRGRSEKMWGVREIQIFARFSVWGVHKDVIEALIEWPREWFTPEEAPIYYATIEDELRYIPVTPQQAQADAQQASSLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9P2</accession>
    <name>S0E9P2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_08292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433695.1">
        <property type="nucleotide sequence ID" value="XM_023581024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9P2"/>
    <dbReference type="STRING" id="1279085.S0E9P2"/>
    <dbReference type="GeneID" id="35401768"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08292"/>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT71616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="364" mass="40843" checksum="CF8EB420E3C47D3D" modified="2013-09-18" version="1">MEGLLYNVNGGYVEGIVRGYRNGLLTGAAYNNLTQCETIDDLKLQLGPSYGDFLASLPPNPSTSALAAKTTDKLISEFRYVRAQAVGSLATFMDYVTYGYMIDNVALLITGTLHERDTRELLERCHPLGWFETMPVLCVATNIEELYNSVLIETPLAPYFKGSLSHQDLDELNIEIVRNTLYKNYLEDFYNFVNTHPEMAGTPTAEVMSEILEFEADRRAINITLNSFGTDLSKQDRNKLYPNFGKLYPEGTLMLSRAEDPEGVRLAVDGVHDYKSFFDAISVGGGPSGPGNMGGGAGETKTLEDMFYQKEMEISKNAFTRQFTHAIVYAWVKLREQEIRNITWIAECIAQNQKERIGNYISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9Y3</accession>
    <name>S0E9Y3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433805.1">
        <property type="nucleotide sequence ID" value="XM_023581159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9Y3"/>
    <dbReference type="STRING" id="1279085.S0E9Y3"/>
    <dbReference type="GeneID" id="35401647"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08171"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_23_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="195"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="472"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="693"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="786" mass="89210" checksum="FCA14D03FE6A5D79" modified="2013-09-18" version="1">MVEPISIIGLVGQISDLIQRAYNYGKAVHDAQSDMRKLYTELLALKGVFEQLEKLDITSAEPHIANLKHSKEFRKTLSSTSELIGRLMKNLNKKQTYSRRVNAFLWPWVKDDVKADIQDLERIKTWFILLIMSENSTQMDVLMIESREILDIARESQARGKLKDEEEKREKIREWIQPFSPKQLHAKAIKKRMKGTGTWFLDGDFKVWREGGAGSPRVLWLRGKSGSGKTTLHAAAVEKLKSVHQEDPRIGQAYYYSSFDDIGSQQPLNILGSILYQISEQHPEALESIDQLRKSGFILGESALLRLISEHMSNFETFFVSVDAMNESLRCMEVFEMLLHLVADNPNVRLFITAISSCSHWLDDLQLEEPPKMMEVDMGTGDADKDIDFYIKNRISEERLLRRLSDVTKLQLREKLLDNAKGMFRYAQCQLDSLRSLRTAKMVLNALNNLPKDIYEVYQKILLSIPEADILLARESLFFLSVALRPLTIQELAEAAVLEDYKPRIDEECRLPEPMVLLEICQGLVDYDAATGVVTLAHSSVRAYITSSFTREGEVGYFSYDISGIHASIANRCLSYLLLGHFQDGCCTHDELEKKFEDYPLLRYASQYWPHHAKLTDRGGRHETSALTLCLSHKKAGGGNFSFWVQCLMPYTSKDTITATEPLYYASSFGLADLVKSLLTSEGVDVDARGGRFKSSALHAACYRGHVEIARQLLECGADVNLRDSDGRTALFWAEKLGRSDIVDLFQDPKYAQTKGRTVVTLSSFPEEIDYPMWFCYVVTRGAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAH1</accession>
    <name>S0EAH1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to allantoate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_08278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433709.1">
        <property type="nucleotide sequence ID" value="XM_023581040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAH1"/>
    <dbReference type="GeneID" id="35401754"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08278"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT71630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="505" mass="55699" checksum="2518D38CD4EA33DA" modified="2013-09-18" version="1">MGTESEVNAAQAPVGTRDEAIAIVGEEQHSIDPIVAARAVRKIDLFLIPAMIIGYGLVYYDKAILGSAVLFGMTTDLHLTIVDATTTPPTVDTRRLSWATSLFYFGMLAGLYPMTFALQRFNIGRVLGGVVVVWAAICMLTAAVTSYQGLYVQRFFLGFVESIIPTGFMCIVSGYYTQSEQSLRQSWWFSSTGLFTIIGGAMNYGFAQITGGGLKRWQYIYLLAGSLTFLFGLFCFIMPNSPVSAWFLTSEERFAAVERLRHGQTGVRCTKFKSSQLKEAVLDVKIWLVALMMASAYTVNGAVSGFGPLIVSTFGWSTLHSILFQFPLGGLCFIVILLTGWLGSKFTNIRIFMLIFTCLPVIAGCAIIWKSEWSYRAAAPVVGYSITGFFGGTVSLIITIGMSNVAGHTKKSFMAATIFVAYCVGNIVGPQLVWSQTKKDHYPALWLGLIICYIICICASTTLYFVLKNENKRRDALGLGDESERAKLAFQDLTDKENPYFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAP0</accession>
    <name>S0EAP0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434027.1">
        <property type="nucleotide sequence ID" value="XM_023581312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAP0"/>
    <dbReference type="STRING" id="1279085.S0EAP0"/>
    <dbReference type="GeneID" id="35407511"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14057"/>
    <dbReference type="HOGENOM" id="CLU_059964_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF8">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="323" mass="34408" checksum="257634AE49999E6F" modified="2013-09-18" version="1">MDRYRALSLFQPPNLNAAIGAVNHEGPSKGPAHLFGAMLGIPHTSMARTVAVLGFDFVFVDTLHVATNPENLVSIIQTINFASEGKTCALVRIPSPDSDLLAYALDAGAAGIVFPQIDTPEQAAAAVYKVRHAYDGGMRSVSPIALLDGITNLAPDGWTSEKIADRNISVICQIESTIAVDNLDAIAATPGVNALMLGVSDLKVTLGLPVRNHDGRVDESSFYEAVEKLIATSKRTGIQLMIPAFRLTPDDADWLRHFKLVMTSVDVLSIMKSHRKDLADVKKTLGMTNEVTNGGTNGRPNRKVSGRANGVATEVASRVSIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAQ4</accession>
    <name>S0EAQ4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_09139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432921.1">
        <property type="nucleotide sequence ID" value="XM_023580082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAQ4"/>
    <dbReference type="STRING" id="1279085.S0EAQ4"/>
    <dbReference type="GeneID" id="35402613"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09139"/>
    <dbReference type="HOGENOM" id="CLU_023417_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT70842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="503" mass="57832" checksum="2FF55CB1C09120C5" modified="2013-09-18" version="1">MAILASDTSENITAFLIMPDAKLRAKTGCAICRQRRVKCDEAKPSCRNCSRFGRSCSWPKPADMTDRRHRRRRASPAPSLSSSDRPSSPKTDETSHDTAPILTNRTTLTTVHHPLFETEIEYELMHHFYNFHFDSLTLPTKDKSYFFQCQSDLMDMMTHSRSVKYAILANCASNKHVLMSNDRYRLIALRYYTEAMGGLNQELEDFCPSDTYRHSCLSTVASFLYVYDFWSLDVMSDPRPHVVGAVKLLSLKNQDNSSLRTAIQSYDRVNIESVLYQGFLLSIRRPFRPDFRLDTNFITHAEDLLRSYDNANPSFAEPSIILGVPTSLYRLILRIIDSSNVPRSNLSDHLQGLKVELQYWEQLLFDDENSEKGQHGDSRFNDLIIIATSLLLDLITETLASNDDTIYPASSAREWDGKPWRWQLDLATNILQCPEEHQKWSGCYLGAWPLLILGYGARSLEEITLVKDVLRKMQERIGYGEVQRIRDELDKITTYKSSQVWVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB11</accession>
    <name>S0EB11_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433031.1">
        <property type="nucleotide sequence ID" value="XM_023580213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB11"/>
    <dbReference type="GeneID" id="35402495"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09021"/>
    <dbReference type="HOGENOM" id="CLU_1704374_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="154" mass="17316" checksum="C8F5DB4734108CCF" modified="2013-09-18" version="1">MAEYVDPLPTFMGPQPSLAQRKEIWDVTYGDKPYTSVVAGPFELALPSYIDFRKLVLGEGNKVYDNLCRLMGPHLVLSWTIVDNKASSLIVGVNPIFNVGAESLFLHQNVRRLWFHVLQWLKVVKQGHNITIVDHLKDILAATISPAQADDFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB41</accession>
    <name>S0EB41_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434167.1">
        <property type="nucleotide sequence ID" value="XM_023581474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB41"/>
    <dbReference type="STRING" id="1279085.S0EB41"/>
    <dbReference type="GeneID" id="35407367"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13913"/>
    <dbReference type="HOGENOM" id="CLU_1138050_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="213" mass="24222" checksum="CB077DE798FF099C" modified="2013-09-18" version="1">MSNQNNDLPQFRGYDRHQDLHPNKRPERIECVGCGSDEHSFSSCLKVGDDVMMRGCPRCNNLSHNASNCRAVKTDKERFIWFVNRRGGMPSFLDFDTWFRLASAEGSLTVHDRSPWTAEFAKFVADDIEQLQDDLDSLTLGVDFKLPEDRKLLGWRAVEMYRQRRAREENVILDGVVTNKKRAAMIVAGDSYPAGESQNAPDASPDTITISRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB80</accession>
    <name>S0EB80_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to D-mandelate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_08959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433086.1">
        <property type="nucleotide sequence ID" value="XM_023580282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB80"/>
    <dbReference type="STRING" id="1279085.S0EB80"/>
    <dbReference type="GeneID" id="35402433"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08959"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF281">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="108"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="190"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT71007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="385" mass="41946" checksum="835914CD4B0F3345" modified="2013-09-18" version="1">MAEPTNTPVPASTPRATSPAPQLPFISQGSLSVRSSMTSSKPRVLHIGDPIKYNPDTYLRFSIQCEVIRPPIEERQRPEFIKALKEKRWGDFDAIFRPFWGTGGEMGKWDQELISLLPQSVKVFASAGAGFDWADTKLLGERGIIYCNSGLAAAEAVADFAIVGIISTFRVLPWCISSAMSGDEEAFKENHRDATMQSYNLRDQALGIIGFGNIGQQIAARARHGFGMDIHYYDVLPKPAAVVAPVRATHHETLESLLGRCDCVVLCTPAGEGTLIDSKTLPHFKRGSRFVNIARGSLVDEDALVAALRDGTLSSAALDVHANEPKIHPELLELAKQGRVLVTCHNAGGTVDTHKGFEELSMRNIMAVLSGVEAITPVNLEFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBZ3</accession>
    <name>S0EBZ3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432002.1">
        <property type="nucleotide sequence ID" value="XM_023579104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBZ3"/>
    <dbReference type="STRING" id="1279085.S0EBZ3"/>
    <dbReference type="GeneID" id="35399325"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05847"/>
    <dbReference type="HOGENOM" id="CLU_099938_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="160"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="236" mass="26292" checksum="D9033D2FF5FCC7E1" modified="2013-09-18" version="1">MPSSDIRVEPITNPDDFTAAFKAVANAFGHQTRDAIWIAFNPGWDTPEGERVGAQRLVDRFSHITTNPDGQPNTIFVKATIDNTIAGLAIWEQASVVPGYGNPPSDLEASGYFKTLYPGNEKEQRFLAQADKSLFKRRIEIINEKAEASPPAIFVMDLCAVDPRFQKRGLASKMVQYGLDEAKRRNLECVTEGSTMGRSVYLKLGFKQEGPETVYNMDDEFKDRDLPSNVVLRTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDE1</accession>
    <name>S0EDE1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable hydroxyquinol-1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434713.1">
        <property type="nucleotide sequence ID" value="XM_023582134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDE1"/>
    <dbReference type="STRING" id="1279085.S0EDE1"/>
    <dbReference type="GeneID" id="35405974"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12518"/>
    <dbReference type="HOGENOM" id="CLU_046727_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="108"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT72635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="326" mass="36427" checksum="835AD43625873344" modified="2013-09-18" version="1">MAAPVNLKDLTIDNITENVHAINSQCSNLRLKYILERVVTHLHDLARETRLTTDEWMTAIQFLTQVGQICTDVRQEFILLSDILGLSLLVDSIDHPKPKGSTEGTVLGPFHTHEAEHVKEGSLISQDSEGEPLLVLCTLKDVNGSPIPGAKIDVWETDSKGFYDVQHADRTGPDGRAVLTSDDNGDFWFKAIVPVPYPIPHDGPVGKLLKVLGRHCYRPSHMHFMFKKDGYDPLITALYLKDDPYETTDAVFGVKDSLIVNIKKVEDEEMAKKYGVKIGSALMTYDFVLVSDEAAAKLRREKAEEAMAKLGRKFRFIDDLPVPDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEE0</accession>
    <name>S0EEE0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to DUF1237 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432862.1">
        <property type="nucleotide sequence ID" value="XM_023579774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEE0"/>
    <dbReference type="STRING" id="1279085.S0EEE0"/>
    <dbReference type="GeneID" id="35399925"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06448"/>
    <dbReference type="HOGENOM" id="CLU_023537_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF1">
        <property type="entry name" value="DUF1237 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485841" evidence="1">
        <location>
            <begin position="20"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="515" mass="57413" checksum="AC51D42A84DC7361" modified="2013-09-18" version="1">MKFLTAVTGAIALLQSADAATWKDYEPQSRTPSSCPDYVDYSQKPHKPLSSGKLKLPFMRPSEECRTFKSPAVEKVISDIKKRVKNPDLARLFENTFPSTLDTTVKYFDAKKNLAFIVTGDITAQWLRDTGNQFAHLYKLLPQDKNLKALVKAIINTEARYISEYPYCGSFQPPPESGLSPSVNDYATLVTVNPPVDNQTVFECKYELDSLAGFLKIARSYYDNTKDASFINDNFKSAMKQILRVIDEQSQSTWAEDWSYISYYNWTGQAGSLSPPVPNSGNGEPKLANGLVGCSHRPSDDLSVFNYITSDNAMMSVELDNVANVLDKVGGQKGLSTTLRGHAETIRQAVWNHTLTANGIFAYETNGYGGQYIMDDANVPSLVSLPYLGFLKRDDPTYKKTKSTLFSRANPYYAVGKKFSGIGGPHANATNPWPMAHVSAIYGTDDDNEITERLNMIMENTAGLGLIHESVNIYNSSVFTRPWFAWANSYFAEMVLDLAERKPGLIFKDDKPYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEF3</accession>
    <name>S0EEF3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432877.1">
        <property type="nucleotide sequence ID" value="XM_023579044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEF3"/>
    <dbReference type="STRING" id="1279085.S0EEF3"/>
    <dbReference type="GeneID" id="35399271"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05792"/>
    <dbReference type="HOGENOM" id="CLU_138804_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="80" mass="9214" checksum="F58B7813E1FCFE83" modified="2013-09-18" version="1">MADKLRTQQELERLQAKYVGTGHPDTTSWEWRTNIQRDTYSSIAGHRPLLSYIALAENEPIIKIRAQMIRPCGPPPPRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF15</accession>
    <name>S0EF15_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435614.1">
        <property type="nucleotide sequence ID" value="XM_023568411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF15"/>
    <dbReference type="GeneID" id="35403129"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09661"/>
    <dbReference type="HOGENOM" id="CLU_117268_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="149" mass="16503" checksum="260ADBF79B34C807" modified="2013-09-18" version="1">MDKATLLTASKVDLNVSTHPRSDITRLIVPSLQIALRFQSLVGSISIFLCLHACIIASSAFVAVLQGSKIVSLNVLIATKYSAFHSFNMSSQAVASAWNSKNVQRLRKKLWYEFAVFILGSGNMVFLMLFWPGWWVLAGACWAGWMLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFQ0</accession>
    <name>S0EFQ0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433297.1">
        <property type="nucleotide sequence ID" value="XM_023580536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFQ0"/>
    <dbReference type="GeneID" id="35402205"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08729"/>
    <dbReference type="HOGENOM" id="CLU_1396437_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485878" description="GPI anchored serine-rich protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="19461" checksum="BEDC5B8B490AE0F8" modified="2013-09-18" version="1">MQFSSIMIAAAGASVAAAQDYAPPAPVLDTTTLTSTTTRVITLTQCNPTVTDCPLRTTTSTEVVVTTSTAAPEVPTTSVYVPPTTSVYEPVVNTTSHELPTIISTPTISTTKKAPSAKTTFYPAGNTTTKAGPTAPGSYTTTKLPVPGSSTDVPGSPGYEAPSPSTVPTAGASGLIASSGFVGAAMVAVMVALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHB0</accession>
    <name>S0EHB0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435310.1">
        <property type="nucleotide sequence ID" value="XM_023567939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHB0"/>
    <dbReference type="STRING" id="1279085.S0EHB0"/>
    <dbReference type="GeneID" id="35403553"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10086"/>
    <dbReference type="HOGENOM" id="CLU_069414_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT73232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30869" checksum="E94B483DF4E6FA75" modified="2013-09-18" version="1">MENPDQLPTAQSFGIETAGIRKSETTVSLANCSKASRFANTIESKRFRFGTRTITASGESSDDVHPNVLRLRVMRTFFDRALQSLFWVISGATGQWLQNKFPEWFLPERIVLKSQKPNWEEEFDKELKAYHKLQPLQGTFIPRFFGMIQHNNIRTLILSDIGGECLATPEGAVLEKQDLRVLLDQTFTSLADHGAYHDDMKLDNFHLVTDEGKDKIMAVDLESVEFDLSGEDLTTVAKGSTEWIIEQYENHLECMELDSVILPKRALRTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIF8</accession>
    <name>S0EIF8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to sexual differentiation process protein isp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_10876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436884.1">
        <property type="nucleotide sequence ID" value="XM_023569710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIF8"/>
    <dbReference type="GeneID" id="35404340"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10876"/>
    <dbReference type="HOGENOM" id="CLU_004965_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="761"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="783"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT74806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="875" mass="97914" checksum="4EB1230F8D93B51B" modified="2013-09-18" version="1">MASQSSVAQGTSADPSQSNTDMASNSEKAITDNGIQATDKREDVVSTGSLKIESVNGRAQILGATPEEILEAEEHARTMDLDEARRRAETLIYLHEHDPNFSSESIMRIQEFLSNEDIFANPHKHEDLITDIKTEISLVTINSPYAEVRAVVSNKDDPSTPAGTIRAWTIGLFFVIVQSFVNQLFSVRQPTIRLQAPVIQLLSFPLGKAWENWFPKGEFTVFGQKLQLNPGKFNQKEHMLISIMANVSTSLPHSRYIIFTSWLKKYFDLPFAADFGFQICLSLAMNLLGFGLAGLARRFLVYPSFCIWPRSLATIALNQSLHNESGNASVLGPFKKMYTMSRYRFFMLSFAAMFIWFWFPDLIASALSLFNWLAWISPNNFTLTAITGVSKGLGFNPLPTFDWNVATYYIDPLLVPFHVTVNMFLGALLGGITIIGMYWNNTYNTGYLPINTNTMFDHTGAKYNVSSILDDRGLLDAEKYQAYSQVYIAASYVTYYIYFFAVYSAIISYAALYHWNDIKLGFVSLWQSFKKNSKINEFKDIHTKLMEQYTEVPEWWYLILNLVGVAFGIASVAGWPTNTSVGTVFFGLALAILFTIPTGIIFATTGIEVEFNVLAEFIGGAWQPGNALAMNFFKGFGYVTVAHALDFANDLKLGHYLKIPQRQTFWCQTVATVVSAFVCTAVMNFQILNIPDICQPTQKDRFTCPGVESYFTAAVLFGSLAPQRVFGEGGLYTALLAAFPVGLAFPVIYYYATRKLPKTHWLAKLHPVVIFSGGHIWSPYNLAYVWPAVIPGWISWVIVRKRYLQFWGKYNYVLSAAWQTGIALAAVVIFFAVSYHGASINWIGNSADSGCEAETCTRLKVPNGTFFGPQPGTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIG6</accession>
    <name>S0EIG6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to ketoreductases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_10615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436637.1">
        <property type="nucleotide sequence ID" value="XM_023569420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIG6"/>
    <dbReference type="STRING" id="1279085.S0EIG6"/>
    <dbReference type="GeneID" id="35404079"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10615"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT74559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="271" mass="29288" checksum="846CD96307BD4854" modified="2013-09-18" version="1">MASAVSKRLEGKTILITGASSGIGKATAFEFARTSPKSLKLVLTARRIDSLRQIAEDIVKEVGDGVKVHPVQLDVSKPEEVRSFVSKLPAEFSEIDVLVNNAGLVKGVDKAPDIKEEDINVMFATNVTGLINMTQAILPIMLKRNNGEGAGDIINIGSIAGREPYVGGSIYCATKAAIHSFTESLRKELISKRIRVIRIDPGQVETEFSVVRFYGNKEKADAVYAGCEPLTPDDIAEAIVFAAGRRENVVIADTLIFPNHQAAATIMHRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIM6</accession>
    <name>S0EIM6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 1</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_13759</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434311.1">
        <property type="nucleotide sequence ID" value="XM_023581644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIM6"/>
    <dbReference type="STRING" id="1279085.S0EIM6"/>
    <dbReference type="GeneID" id="35407213"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13759"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT72233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="233" mass="26180" checksum="45BEE5AED6B65C5E" modified="2013-09-18" version="1">MSRDRRVAKELRDIEADHDDSGVNATLVNNDLKHLKGTFPAPPDTPYAGGTFTVDIQIPDQYPFKAPMIRFDTKIWHPNISSQTGAICLDTLSSNWSPVQTIKTALLSLRMLLECPNPKDPQDAEVAKMMIEDPKRFALMAHEWAVKYAGAPRQDVDVTKYQNDVAAAPVKDDVARLSGYNRDLVERFVNMGFALDDVVEAFIHFGIDRNGGRDYELEEAYMGDVVSRLLHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIX4</accession>
    <name>S0EIX4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434411.1">
        <property type="nucleotide sequence ID" value="XM_023581765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIX4"/>
    <dbReference type="GeneID" id="35405645"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12189"/>
    <dbReference type="HOGENOM" id="CLU_067863_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496088" evidence="1">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="264" mass="27542" checksum="EB1A954AB00E566C" modified="2013-09-18" version="1">MQLSTFVASVLAVTASAAPTYPTITVTDAGSAIDALGSLSGYFNLVADKVKAVKSYGMAPVCDLSQAKMPLDGQLPSPAKGLKLVHVAIGRGTQNYTCDTSKPSSAPVATGAVATLFNGSCVAAMYPDLIERIPGMAVHFPLSDANKLGPASLAESGHHYFTADGTPFFDLRTPNQDIGEAPCAKNSSAPAPSLSAKGQLGENAVPWLRLTTIEGATHKMKEVYRTTTAGGSAPATCQGMDAEFEVQYATLYWFWAGDIEEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJE2</accession>
    <name>S0EJE2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to gibberellin 20-oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436982.1">
        <property type="nucleotide sequence ID" value="XM_023569822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJE2"/>
    <dbReference type="STRING" id="1279085.S0EJE2"/>
    <dbReference type="GeneID" id="35404441"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10977"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="172"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="337" mass="37588" checksum="41A6909D37195099" modified="2013-09-18" version="1">MAALNADTLDMSLFFGTPSQKQDFCDSLLRLLKKRGGVKLINHPIPSAAIHELFAQTKRFFNLPLETKMLAKHPPQANPNRGYSFVGQENVANISGYEKGLGPLKTRDIKETVDFGSATDELVDNLWVPEEELPGFRGFMEGFYEMAFKTEMQLLEALAIALGVSPDHLKALHNRAENEFRILHYPAIPASELADGTATRIAEHTDFGTITMLFQDSVGGLQVEDQENLGTFNNVESASPTDIILNIGDSLQRLTNDTFKAACHRVTYPPSIKAGDGEQVIPERYSIAYFAKPNRSASLFPLKEFIEEGVPCKYEDVTAWEWNNRRIEKLFSAEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK14</accession>
    <name>S0EK14_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to tetracycline efflux protein (Otrb)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_10259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436295.1">
        <property type="nucleotide sequence ID" value="XM_023569022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK14"/>
    <dbReference type="GeneID" id="35403724"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10259"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000436">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT74217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="507" mass="54633" checksum="2B7C5F9666BEAC1D" modified="2013-09-18" version="1">MVLTKDEKALHDQVNILPRRQLIIALATLSSALLLVTIDQNGISVTLPTIARDLNAEATISWAGTSSLIANTCFQMLYGRLSDVFGRKVVFISAALLLCVSDLLCSFSQNAVMFYVFRALAGIGGGGVLNLNNIIISDIVSLEQRGKIQGITGATVGLGNIIGPFIAAGIMERSSWRGFFWLLTPLSFLTAVLSFFFLPSKPPTISFKEGITKIDWVGSWVSGVGIVLLLIPISGGGSYFSWDSPLSISFLAVGGSLFLAFIGWEWKMAKLPMMPVDIYKNSSISIMLAQNFLLGAVYQSYLYYVPLYLQNPHQYSAMKSAAIYTPLVAAQMIASVGSGQYISHRLRYGEVLIFGFAVWTLGAGLALLLTRHSSIAVIAVILGVVGLGVGCIFQPTLIALQAHSPKSRRAVIISNRNFYRCIGGACGLAISAAVLQAQLRATLPTEYKDLASSTYVLPESVRQVPAVLDAYMSASHSVFILQVPLIGLCLLGTAFIRDRGLEPVKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKI0</accession>
    <name>S0EKI0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_11527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437549.1">
        <property type="nucleotide sequence ID" value="XM_023570436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKI0"/>
    <dbReference type="STRING" id="1279085.S0EKI0"/>
    <dbReference type="GeneID" id="35404989"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11527"/>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF123">
        <property type="entry name" value="GMC OXIDOREDUCTASE (AFU_ORTHOLOGUE AFUA_2G01770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="490"/>
            <end position="491"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT75503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="549" mass="60109" checksum="A82853FA63046E2B" modified="2013-09-18" version="1">MASPIYDYIVVGGGLAGCVLSSRIREYDYAAKILLIEAGKETRGRSDVHNMQVLNLGGELDWQYQSEPVEALMGRRITLNAGKGLGGSSAINSGGWTRGAAADYDEWAALVGDERYSYKGQLPWFRKSELWFDDKNPEQHGRDGPIRVTCAKASNRVFPLAEKAAAGWEELGVSTLLDGDQNSGNNLGRAYIYEARSDGKREWSANQYSLDGVQVRLETFVNRIVIQKIDGNLKATGVELADGNVVNGHNIIISAGAFRSPQLLQLSGIGPKTHLQEFGIEPLIDLPEVGKNLSDHMIFFQHWQLRDHSAGHTIGSANPLFHQPQYSQGVPFDWIVNTGIPRNGLAKAIERDEGTEPRESEHVLLAKDRTFIENIIMFAKLPFPGVPIDAEHITSALVSFLPTSKGSVSLKSGKPGEHPRVNLNYLSTEVDKHVFREGLRQMTRFMLESNFSHQIIGESIPEGLPVEALALDDSDDKLDQRIAMTGGTSWHPSGTCSMGKVVDTEFCVRGVEGLRVVDASVFPVPLSAHLQAPLYALSEQAAAIITGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKQ5</accession>
    <name>S0EKQ5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cutinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435056.1">
        <property type="nucleotide sequence ID" value="XM_023582533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKQ5"/>
    <dbReference type="STRING" id="1279085.S0EKQ5"/>
    <dbReference type="GeneID" id="35406332"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12876"/>
    <dbReference type="HOGENOM" id="CLU_040058_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485385" description="Cutinase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="22872" checksum="5F51981D0A1D14DF" modified="2013-09-18" version="1">MLSQFITFLALTGCAAAAPNPRAAKCTSYTIINTRGTGEIQGPSAGFRTMNSQITSQLPGGKIYNTVYLAGYDQNSAQGTQDIIREVNSVLASNPSECFILEGYSQGAAATVNALSQLTGSAGDAVKGVFLIGDPLHKSGLACNVDNNGGTTTKNVNGLEAFGGGGIPQNWISRTLDVCIFGDGVCDTAHGFGINAQHLQYPNDAATQKLGTTFVVKQLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKS9</accession>
    <name>S0EKS9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to PMU1-high copy suppressor of ts tps2 mutant phenotype</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436580.1">
        <property type="nucleotide sequence ID" value="XM_023569355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKS9"/>
    <dbReference type="GeneID" id="35404021"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10557"/>
    <dbReference type="HOGENOM" id="CLU_039184_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="286" mass="32616" checksum="27392901E422B023" modified="2013-09-18" version="1">MSGPKCSYKFTFEPDWLVDYPVISHSYPGSKLTTQPNLGLRNDREWARLTEHVKQSNDQDDSDVSHKILLVARHGHGVHNDVMEEVGSEEWKNHWSKLPGDSNRTWLDAELVEKGVQQAKDVGKLYTEGIRHAGFPVPDAIYTSPLARGLKTTNLIFRDIITEQGTEFRPIVKEYLRERLTNHTCDKRRTRQWIQAAYPDYELESGFAEEDVLWHADRSESNEAHVARTQELLEDVWRHDSGSCIALTTHSFTISTILEAIGAPQFRMGEGAMVALLVKGEKIYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKU2</accession>
    <name>S0EKU2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable potassium transporter TRK-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_11478</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437502.1">
        <property type="nucleotide sequence ID" value="XM_023570381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKU2"/>
    <dbReference type="STRING" id="1279085.S0EKU2"/>
    <dbReference type="GeneID" id="35404940"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11478"/>
    <dbReference type="HOGENOM" id="CLU_005947_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF5">
        <property type="entry name" value="POTASSIUM ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT75456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="648" mass="72194" checksum="74791FD6B6457C77" modified="2013-09-18" version="1">MPAIDAWFFGASASTESGLNTIDVKDLKTYQQLYIYFIPILTNLGFINIVVVIVRLFWFKRYLKRLAPQALDYSPAIPDVDIESAQHESKVLADTNENSAKTTDEPNGKAKATNDCIEEDAALANEDRRVARTTAITFDPSTERHKEDDALYIPGPRARDRGYPIAPRSHEAAQHPDDSDDDDAIKPVPNETQNNGSSSMRRRRFSNDDGLKVTASRSMDRVAGVAASFLVLGSQIEPQPRPISSHSNQQPAINDVPFLSRQATLGRNSQFKNLTSHDREILGGIEYRSLKLLLKIVVVYFFGLHIFGAVCLVGWIHTADKQYADILQSSAQDKTWWGIYSAQTMYDNLGFTLTPDSMISFRTAKWPMILMSFLAFAGNTLYPVFLRLSIWIMSNLVQKTSPTQESLAFLLTYPRRCYTLLFPSGPTWILFGIIFALNFTDILLIIVLDLSNPEVASLPLSQRIPAAIFQAASARHTGTASFNLANVSPAVQLSLLIMMYIAVFPIAISIRASNAYEEKSLGLWEEEKSLDEKHSKTYLLTHMKNQLGFDLWYIFLGTFCICISESTRIADVNEPAFSVFSVLFEVTSAYGNVGLSLGYPTVSTSLCGMFGTFGKAVICLMMIRGRHRGLPYALDRAIMLPTGQIAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKX5</accession>
    <name>S0EKX5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_11312</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437343.1">
        <property type="nucleotide sequence ID" value="XM_023570195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKX5"/>
    <dbReference type="STRING" id="1279085.S0EKX5"/>
    <dbReference type="GeneID" id="35404774"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11312"/>
    <dbReference type="HOGENOM" id="CLU_014602_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005146084" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="49"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT75296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="648" mass="69953" checksum="2DC9F865CEEE4E22" modified="2013-09-18" version="1">MLGFVALTLWLSTAIAAPEDTALIPRVNSVGIRALPNSPSGGYAPKVVDCPSTRPKARLADGLSSEEESWVRRRRNNTIDDLKTFLSRANISGFDAESFVEKHKNNATGLPNIAIAASGGGYRALMNGAGFLSAADSRNNKTGPISGLLQSATYLAGLSGGGWLVGSIFANNFSTVPDLQSGDKVWRFDRSIFKGPKSSGISLLNTAEYWDEMKDAVDDKDKGWNTTLTDWWGRALSYQLVNAPEGGPSYTFSSIADTSNFKDADTPFPILVADGRAPGERVISLNATVYEFNPYEFGTWDPTTFGFVPTEYLASNFTNGSISSKGECVRGFDQIGFVMGTSSSLFNQFLLNNITKVGKENDIPDIVVKAIEGVLVGLDQDDEDIAQYAPNPFFGWNPTDKSVNSKDRQLTLVDGGEDLQNIPLHPLIQPVRGVDIIFAIDSSADTDNNWPNGTALRATYDRVGSSIGNGTLFPSVPSAETFINEKLNQRPTLFGCDANNFTLSDGEVPPPLIFYIPNAPYTYHSNVSTFDMSYTTTERDNIILNALNGATQGNATIDKEWPTCVACAVMSRSWWKANETVPDACKTCFDRYCWDGKSNNTAVKSYEPEYIIGGNATAEAADNAAGARLGPSWFVSAGVGAAALFALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL78</accession>
    <name>S0EL78_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435206.1">
        <property type="nucleotide sequence ID" value="XM_023567811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL78"/>
    <dbReference type="STRING" id="1279085.S0EL78"/>
    <dbReference type="GeneID" id="35403669"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10203"/>
    <dbReference type="HOGENOM" id="CLU_010194_8_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="266" mass="30155" checksum="882FD123A0FA9CC8" modified="2013-09-18" version="1">MALEIDEVEETAALCREINPKVLIKVAAFDVTNYQQVEGFVKEADAEFHGLHVLLMNAGRPPQWLLTAESDPAIWWNTVAVSLQGGFNFIRTVLPIMQHQGDVRIIFTSSSGAHTNFGMSSYVLGKLRLVRLSEIIHHENFKDYIVKCFSFNPGVIRTRFFTDFRDHFEGKHRNDGYLSHDAENEDKSAETAVKILESVTPHTPELAAGLVTVIASRKLDLMSGRYLDATRHVEDYQREEETIRNNDLHRVRLNAGSGLFLPNLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL99</accession>
    <name>S0EL99_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436760.1">
        <property type="nucleotide sequence ID" value="XM_023569562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL99"/>
    <dbReference type="GeneID" id="35404208"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10744"/>
    <dbReference type="HOGENOM" id="CLU_078564_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496124" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="24992" checksum="EB5B671121F959A5" modified="2013-09-18" version="1">MKVSVIYSLAALFGASCVIADCIEGHRETITPDYVVEHKCNMYRTGTTRDAIASAKDCAALCQAAGVEVCSYHPPTKRCIVSKPDGEDRVRSDVIYMAKVEIDDPFVEPDPFDMTDAEAKEACFAREAALKSELAECKATAAASGSESSHSSCAQCGILGKNDPGHFSRRLKTDLAACKAGCAAVGDGTTCRSYAHDGGSPGTCLLYYKHIRELKPAGNFKAEGAWRSWDKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELG1</accession>
    <name>S0ELG1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to thermophilic desulfurizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437687.1">
        <property type="nucleotide sequence ID" value="XM_023570598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELG1"/>
    <dbReference type="STRING" id="1279085.S0ELG1"/>
    <dbReference type="GeneID" id="35405134"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11673"/>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="42"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="484" mass="53910" checksum="4ADB57BF947F3796" modified="2013-09-18" version="1">MASNPATNESTIDNRNNDLKKKIIINAFDMSTIGHLSPGQWKNPVDKSATKRDLQYWIDLAQLLEKGGINALFLADTYGGYDTYEGKLDNCIRRAAQWPMTDPTIPISAMAAVTKNLSFAITASTSFEPPFLLAKRFSSLDHFTRGRIGWNIVTSWKKAAFKAIGLDSPIAHDERYEQADEYLRVLYKLWEGSWADEAISPDPENDSYADPDKIRTIHHHGKFFDLDTRHIVDPSPQRTPFLFQAGTSSAGQTFAATHAEGIFVSSHSPKLLKPKIQAIRKQAAELGRDPQSLKFFATFTPIVGRTDEEAQEKLKELKKYASTIGGLVLVSGWTGIDLSKIPLDQELTSADSLEKHKVQSLLDAFTVTSEHVPKWTPRVIAEKAGIGGLGPVSVGSPQTVADEMERWIKEGDLDGFNVGYVTTPGTFEDLVELLVPELRRRGLYHEIPSEGGHTLRENVYGIGQSKLRDDHTGSKYKYDVFKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELG7</accession>
    <name>S0ELG7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to quinate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_11484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437508.1">
        <property type="nucleotide sequence ID" value="XM_023570388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELG7"/>
    <dbReference type="STRING" id="1279085.S0ELG7"/>
    <dbReference type="GeneID" id="35404946"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11484"/>
    <dbReference type="HOGENOM" id="CLU_008719_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT75462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="606" mass="68571" checksum="684B7F885445ACB9" modified="2013-09-18" version="1">MSEDNARKRPRQPTSDPRYPRKRSLKACHVCRARKTKCDNVQPTCGFCASLNISCSYDNTEKDHSTFDPASLEILRQLGQIITSQDELAQTVRSIAAAQSHAGLGAAQNVHVADGLNWDANLQTQQLPYYDWSGGQSDSNSTTPAASASVAAVRWFGILANDASNEAFPDSDAPLGLDGELLDTSPDGQTDSDITPLQKATRIIDTQPPTRDAVHNHAANSSEESLWQASESISLLDREQTLFQNFLHRICSWLDLFDPARTFSTRVPHLAVRNAGLLNAILALSCYHQSLDETILPNQRPSQNTALQYYYQTLHYVQKAMRYSTYQNSQELMATTLMVSTYEMLRGSRKDWQQHLQGVFWILRSRQIEVETSSLESTTWWAWLRQDIWVAFREKRRTHSTWMPKKGYADLDSHELASRAVWIMAQVINFCAVDSSAEVEGLTGRIGWAKALRKMLDEWRSHLTVEFSALPTMGNRESEVFQPHLIHPQCFGLAVQLHHCSRILITAHEPHLDGIQGLLKRQKEIQESIKMVCGIGMTLTEDASSMLSSQCLFIAGMFMQNPRERECVVEMLDTCQKRCGWPTPSLRTELEQIWENPDALWDGQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELS1</accession>
    <name>S0ELS1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable actin-like protein ACT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435421.1">
        <property type="nucleotide sequence ID" value="XM_023568067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELS1"/>
    <dbReference type="STRING" id="1279085.S0ELS1"/>
    <dbReference type="GeneID" id="35403438"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09971"/>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="390" mass="44046" checksum="69EF29D635F5CF24" modified="2013-09-18" version="1">MSNPPPIVLDGGTGFLKVGYAAQNFPEHQYPSIVGRPILRSEEQTDSDVVIKDIMCGDEAAAARTMLQISYPMENGIVKKWDDMEHLWDYTFYEKLKVDPTGQKILLTEPPMNPLKNREKMCEVMFDRYNFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESVVLNHLTKRLDVAGRDVTRNLIKLLLRRGYALNRTADFETVRQIKEKLCYVSYDLELDKRLSEDTTVLVEDYTLPDGRVIRVGSERFEAPECLFQPHLVDSESPGLGEFLFNTIQSADVDIRSSLFKAIVLSGGSSMYPGLPSRLEKELKQLWLTRALQGNPERLSKFKVRIEDPPRRRHMVFLGGAVLANIMADKESMWVTKAEWEEEGTRVLEKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMB4</accession>
    <name>S0EMB4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_11794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437803.1">
        <property type="nucleotide sequence ID" value="XM_023570733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMB4"/>
    <dbReference type="STRING" id="1279085.S0EMB4"/>
    <dbReference type="GeneID" id="35405255"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11794"/>
    <dbReference type="HOGENOM" id="CLU_018202_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="138"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT75757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="473" mass="52570" checksum="66383C3B6A7D1F23" modified="2013-09-18" version="1">MTTLSTTTRSRAAQGLTLTLRPTSRVRRDSLIALARYSSTNAAAALEATRTNTPVAKGAESPLSELPPLVLYRSLLVNSVSSRPWLLIPSLHLLQKLSNPTNPYLFNVDRNPLLRSLLKHTFYKQFCAGETGAETQSTMKSLQDMGFKGTILTFAKETVFDAKTGKGQGFGIEASSSNECQWCENIEAWREGTVRTVELLREGDQLAVKMTGAGPGVCDAFANGTELPKQFVDASHEIAQKCKDRGAYILIDAESQHYQWGIFRLGMELQQKFNTDGKVVLYNTYQAYLKSTHDTLAKHLQAAVDKGFTLGIKVVRGAYMASDPRSLIHDTKQDTDDSYNQIAQGVLRQEFRSFGTSKPFPSAQLLLASHNKESLVKAHETHQERTKAGLPTVPVKFAQLHGMSDEVSFGLLKLKDDAGVAPEVYKCTTWGTLPECMAYLTRRAMENRDAAARTLDEYSALKSELWRRLAFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMM9</accession>
    <name>S0EMM9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription factor Pig1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_11933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437933.1">
        <property type="nucleotide sequence ID" value="XM_023570888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMM9"/>
    <dbReference type="STRING" id="1279085.S0EMM9"/>
    <dbReference type="GeneID" id="35405393"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11933"/>
    <dbReference type="HOGENOM" id="CLU_003864_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="821" mass="91820" checksum="92AFD2A24C1298EB" modified="2013-09-18" version="1">MSLTCTVCNTRFQRAEHLNRHLLRHLGLRPFQCAICHAQFSRRDSLKRHALNDSDASTSSEAPADPPPRGGRYAARACSSCRHSKQKCDGKFPCRRCTAKKQACVYLPNERHQNTLIGDTSPHTVSGSESVNQEHPVVNADVEVLSSNQQSIEAIESSFEPIPPLPEWNPEAWLTSDSVFQDILQDISFVNVPWPFNIRVGEVGAPERSDKNDASWDHLLIPNPCPTDPIPRIDLPQFLENSESGLPEEVSTSCGPGASDKPSINCPSILEPHLAWTAENDICDAEDFGHVPRISMDVYKIIRTKFEELNGDSSTSQPFTQTEFPSSTVLNAFVQSYFEYFHPGFPMLHKPSFDPGSNESSWLLVLAVATTGCRFSLASSPQILFLLQESLRRSIIRILHVDYDECVIHNLPLAQAAILSQVGMMFSKHQKFSDYAESTACLIATMCRKANSHSDFEPRHGGDTSSSEKEATGNSSPNKSWKAWVAEESTSRMVYCCLLLDFQFSALFDLPALIDIDSIHLPMPCSENLWNADTEELWHSNMTQEPRESLMTTIRKSLQYLYDNKTTSPGLGRFGALILTFAIYRDEIDSEAKYNYLSMVRPDEAHLQSNGSLDQLIFQHNHTLSLFTKLPPRQLFAFSGWRTTVAQQKKAEKHIRDWLSEDMAGSRLCLVHAAKVYSSVRSTRTYGHHEVMAILLSTLAIWSISSIHRVVSSSSSDESLPIYHAACAQDSSEALAKKRTIRLDKTLDGSLLAAWISGQVDFRPYLAGIGTLDDQGTVRRLIRDSLQQLMYSVTWCLGQAVAEVLKTHYRTKTGDLGISQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN80</accession>
    <name>S0EN80_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437460.1">
        <property type="nucleotide sequence ID" value="XM_023570334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN80"/>
    <dbReference type="GeneID" id="35404897"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11435"/>
    <dbReference type="HOGENOM" id="CLU_079904_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="202" mass="22266" checksum="5CF55084DD54E25C" modified="2013-09-18" version="1">MEDTRQLPDGIIELAPRTGTSFFVNKGQRLTVVDPKGGQVSDLVAFNRHDTDEVISNGRTFDYADTIYLTTNHPLYSNRSNVMLKIIDDTCGRHDFLLTPCSKDTFRIIYGDKEPHHGCFGNLSLALSKYDIAPDRIPCAFNCFMNVPVDGKSGKFTVEPPISKAGDHIDFVAEMDLIIAITACSAGKSNGGSFKPIQYKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP04</accession>
    <name>S0EP04_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to hexose transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_10573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436596.1">
        <property type="nucleotide sequence ID" value="XM_023569372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP04"/>
    <dbReference type="GeneID" id="35404037"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10573"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT74518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="529" mass="58205" checksum="D023834B7BB9CC2B" modified="2013-09-18" version="1">MGSSPAEKKGAAAAAGNDLAAVLPDDARPWYRVPHLLKLNLLLLIPLVSSGAIGYDGSMMNGLQTLPQWRGYFGQPEGAMLGALNSVYPAGKVIALFFVTYVCDRFGRKTAMMVGALSCVAFAIMQAVSQNLETFIAARAILGFFTSFLAQPSPILITELAYPTHRGKLTALYNTSFYLGGIIAAWCTYGTFKIDSTWSWRIPSLLQGALPFIQLLAVYFLPESPRWLVAHGRREEARKILATYHAGGDANAPLVNFEMAEIEGALTHEADAMSQNSWLELVRTPANRKRTLIAVIVGWFAQWNGINLVSYYLVLVLNTIGITAAKEQTLINGLLQISNWLAAIFVGAMLVDRLGRRTLFLLSTCGMFVSYIIWTALSASFDSTRSPTTGKAIVGFVFITFFFYAIAWAPLLQAYTVEIFPYTLRSRGVSVMYVSTFVGLVVGNQVNPIAMKNIGWKYYIVFCCILACLIVVIWFLFPETKGHTLEEIQAIFEGTSHGALHAGKLDDIEHGRLDQDGKKDKKVDQVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ31</accession>
    <name>S0EQ31_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438236.1">
        <property type="nucleotide sequence ID" value="XM_023571181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ31"/>
    <dbReference type="GeneID" id="35407629"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14177"/>
    <dbReference type="HOGENOM" id="CLU_1586612_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="168" mass="19116" checksum="0D863BF7EB82F757" modified="2013-09-18" version="1">MPTSTNLHHDNFRSSSALWLRSAQSHTTVADTATPSPWGVTLDRQRARTTLAISKSRPKRNHLAGSAIPQAISRHILSRPQKRMAAKDKKVTTSGTENDRPSIEDLGEIFDEITRERLGRRDPITRRWQRKTWASPIWAIKSGHYNMQMLPHETTPTSNDRRRGPFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHL7</accession>
    <name>S0DHL7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423785.1">
        <property type="nucleotide sequence ID" value="XM_023574528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHL7"/>
    <dbReference type="GeneID" id="35395298"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01814"/>
    <dbReference type="HOGENOM" id="CLU_079410_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="305" mass="34421" checksum="5B386338827730A4" modified="2013-09-18" version="1">MYVARPERTRKPSSRPLYSNAVAKPSTKKHKQSQQKRPDTPTKTAECIEVSSSPTHPIAAHKKHDVAPGAVVSATAYKHIPPGAVVSPMTPEVLRTLAKPGTSQVFGFWLLNQVEHIYVDYRNYCLKEDEYGYPRKTKLGMLEVNVPENGTAIPFDIMSVKHPSFQKVQLLQGVQFIFYSPESLVRFANILVSTLFLPRLLPIVPCVQIKLVIFDPTCLPQAPELMAWQEIGVDQDPPASWTLAYKHYDDWMKAVKKFCKLPVAALVTLHFCYPYRDFDNLESLSKPLRVTENLGLLAIDFEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHM7</accession>
    <name>S0DHM7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423805.1">
        <property type="nucleotide sequence ID" value="XM_023574772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHM7"/>
    <dbReference type="STRING" id="1279085.S0DHM7"/>
    <dbReference type="GeneID" id="35395276"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01792"/>
    <dbReference type="HOGENOM" id="CLU_001366_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057503">
        <property type="entry name" value="PH_RdRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF17">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25358">
        <property type="entry name" value="PH_fung_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RdRP-like PH" evidence="3">
        <location>
            <begin position="146"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="440"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1271" mass="144116" checksum="84F6C6E03B7B941B" modified="2013-09-18" version="1">MEVFCRNVPQDLSEESFKQELIPFMKALNIADFFCDKPKRKPQAWIKFLNPGDGYSFLERHGKHQRHDLPQKENINPRYPFKTNFRPKDTPRLHILKTAVFVEKSTRVLDKHSIAHLKHERAKEQQKAAAAASAAATTKDRQAPVKTFIISSISCGGNTFRGPEQVITFVEHNNLILLGDVIGKFTPQWLTVHDEAGYRMDFHNDTIQDLIASRNDASITLVLTEPPKMYTPHKSDNPNQAWKRVQGLVNWGLIREYSSSCLVYRIFFTSLNDMNEVLRSVKHRDILAVTYHDLPSVLWSYMEPESNHFLGREQFAEKAKRLLASGNVHFALLFQVQALVWDNYINPASGIELLHILDEVITDAKVKKVAAPVTTGAMKTLLQKIPYPCPGTDPDELNVVTLMASIMNEEYEARAENPKRDRIYGAKIPDHQIYIFKAMVTPTRVLLSGPEPDSKNRVLRKYHENNDYFLRVLFCEEDGQDLDFHPKVDNEPIFARFRHVMDEGITIAGRKFDFLGFSHSSLRSHSAWFSAPFTDSNFERQTPAAILQALGDFSEIRVPAKCAARIGQAFSETPYAIPIFETGISHRFIPDVKSEDGTRVFSDGVGTISQDALEEIWPYLSMRAAAPTCLQIRWGGCKGMLSLDTRLKGKVFCIRQESMMKFPSDDLRELGICDASSKPLRLVLNRQMIKILEDMGTPNDWFFRLQNNALDILRNVTADATNTSYFLDYQAIGVNMGLPKLVKQLYKMGIDYRRDKFLKSAVEHVVLRELRLLKHKARIPVDQGVTLFGVMDETGFLNAGEVFVTYDKTHGVYRGRRNNSTLKDGRIIVTRSPALHPGDIQIVNQVTPPQGHPLRSLQNCIVFSQKGKRDLPSMLSGGDLDGDLYNIIWDPEALPGKYFLPADYPRVTPKPLDRPVKPQDIADFFVNFMRTDILGMIATRHVVLADYYEEGTTHPYCISLAGMHSTAVDFSKTGIPVDVKDLPRNPPFRPDFLATAPPLKTYEKGQIAHLHDEDEGDNADDGMARYKAKYYESDKILGRLYRNVDEKKIWDEDIHRIINTAGPSVWDQLLTVVESEVNKYKLDVDWTRRSDEAWKIRGLYESTIADKMWHFSENPRAPLTEVEVFCGFILNKRGAQTRRQGDSSIKLKEEIDRIMTWIVKQIRDRGVGDDAETLSTATDADATPSRWREDIVELCWACVAVACIRKEFAPIVYHGTGELESFRIVAACCLLKELINLARKMEISAGGGFVGVGRGRGGRGRGGAGMILPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHR9</accession>
    <name>S0DHR9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423641.1">
        <property type="nucleotide sequence ID" value="XM_023571196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHR9"/>
    <dbReference type="GeneID" id="35395442"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01959"/>
    <dbReference type="HOGENOM" id="CLU_104284_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="218" mass="24487" checksum="847931848B52742A" modified="2013-09-18" version="1">MSPHSSTQTQTQSKLCQLPSKVLFGVVGSTSDYSDKMNLSRTCRKLYDMLILHIYSDAGERLKWRYMFEAAEDGNCRTLARCLEAGAPVDYREPEDCVRPLQMAIAFCRPLTVKWLLAHGANPNSMRDDNQSIYATCPLGAAVDLAIRPRIGWDIPLRWKFKGSKTPGSKRLAQNAREMIKILRQAGAQEQSLGDLERVHLDSIEAGAFCCPQHKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHW3</accession>
    <name>S0DHW3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable ATP dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_01879</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423726.1">
        <property type="nucleotide sequence ID" value="XM_023573818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHW3"/>
    <dbReference type="STRING" id="1279085.S0DHW3"/>
    <dbReference type="GeneID" id="35395362"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01879"/>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="167"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="403"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT61645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1039" mass="118018" checksum="D2299C8234CB7E9D" modified="2013-09-18" version="1">MDEMFDVFEGKVDAPSASEDEHVTNRKGDTKKRKANAINGENGDAAKTEDVDMDAKTESSKDEGDSSDDEESSESASQQDSKRRKKEDGVGPVMADTFQTAESREVAGAATFTEQDSSLVLSHNIQHQVALPPDLDYEYVPLSEHKAPEQPARTWNFKLDPFQSLSVASIEREESVLVSAHTSAGKTVVAEYAVAQCLKRNQRVIYTSPIKALSNQKYRDFEAIFGDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEIMREVAWVVFDEIHYMRDKIRGVVWEETIIMLPDKVRYVFLSATIPNAFQFAEWIAKIHHQACHVVYTDFRPTPLQNYFFPCGGTGARLIVDEKSNFNEQNFNKVMQEVEEKKGADPNDPNARQKGKGKNKKTNKGGADSGSDISKIIRMTIKKKFNPVIVFNFSKRECENLAMNISSLSFNDDSEKAMVRKVFNSAIESLSEGDRELPQIINLLPLLERGIGVHHSGLLPILKETIEILFQESLIKVLFATETFSIGLNMPAKTVVFTQVTKWDGVKRRPLTSSEYIQMAGRAGRRGLDARGIVIMMIDDKLEPDTAKEIVTGHQDRLNSAFYLGYNMILNLLRIEAISPEFMLERCFHQFQNAASVPSLEKELMTLQQERDNTSIADESTVKDYYQIRQQLSAYTKDMRTVIQHPNYSISYLQPGRLVQIYNPNQPVEDAPMPVGLKPFGDDDDDDVKFAVVPCLLTCIKAISQIRLFLPKEGLKSESERETLTKSLMEVKRRFPDGLPVLDPIENMEITDESFKKLLRKIEVLESRLLANPLHLSPLLPALWDQYHAKVKLTEKVKETKKSIAKAYSIAQMDELKSRKRVLRRLGFINDSEVVQLKARVACEISSTEGHELLLSELLFDRFFNELTPEMCAAVMSCFIFDEKIETTQLKEELSKPYREIQAKARIIAKVSQECKLEVNEEEYIQKLKWQLMETVYAWAQGRPFIEICKMTKVYEGSLIRLFRRLEELLRQMGQAAKVMGNDDLTKKFEDSLSKIRRDIVAAQSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI80</accession>
    <name>S0DI80_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423941.1">
        <property type="nucleotide sequence ID" value="XM_023576373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI80"/>
    <dbReference type="GeneID" id="35395133"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01648"/>
    <dbReference type="HOGENOM" id="CLU_2236801_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="105" mass="11604" checksum="53BC09D80A01D22B" modified="2013-09-18" version="1">MAEPGGFGPEIQTSLLFELEEVGKRLLKDTGVFYRGIADPLIAMEVTVTMYTSVSPVKLDVSQQLDGYSLTVPSLIGPFFRPTVQHTMPVKLRVPPEPADVEQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIW0</accession>
    <name>S0DIW0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_01352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424207.1">
        <property type="nucleotide sequence ID" value="XM_023579684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIW0"/>
    <dbReference type="STRING" id="1279085.S0DIW0"/>
    <dbReference type="GeneID" id="35394837"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01352"/>
    <dbReference type="HOGENOM" id="CLU_089358_2_0_1"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="196" mass="20436" checksum="FD0C3EDF914F89CA" modified="2013-09-18" version="1">MSLKGPSPQHHDGSGLRIGIVHARWNSTIIDPLVTGAKEKLLAAGVKESNIVIQSCPGSWELPIAVQRLFSASQIQGTSTGGPSATDLLASSTTDLTSLPASSGAFDAIIAVGVLIKGETMHFEYIAESTCQGLMRVQLDTGVPVILGVLTVLTEDQAKARAGVDGKGHNHGEDWGLAAVEMGVKRKEWANGTIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIX5</accession>
    <name>S0DIX5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424316.1">
        <property type="nucleotide sequence ID" value="XM_023581039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIX5"/>
    <dbReference type="STRING" id="1279085.S0DIX5"/>
    <dbReference type="GeneID" id="35394715"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01230"/>
    <dbReference type="HOGENOM" id="CLU_452730_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="327"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="603" mass="65418" checksum="B524BBF5A8BC7D8E" modified="2013-09-18" version="1">MDPMDFMLSSNHRASGHYDPVHSASNHWAPHSQAQNLPAYPWHVQNPSLPHIYSHPYTMPPHSSVPDPYGHHAAMLPPMLGMPSPGPFAGSMPGPASPRPNGRAHAYRNSMPVAVAPIPSGTGSYNHDAAFANQIPANRPSDFQPPGLGLGMPPLGANHQEVNSLQRSAYVHGDSSANGMNHSNTGYFPQFLPAPLPPQTHIPAPTRRGHFTAASSSSRPFGNLPSPTRPAPSSSGFRRFHPRQRRRIMSTESGHDDNEDDGYHGHHEHVLYSPNGSESSPEVEEALIRQMQFVRGSLTTKMVASQLTLQSLVSVKLEDLAETDRSCVICYNEYGVDTPEGIKEAPLRLPKCGHVFGDHCIKKWFEDSDSCPYCRDRLHSEPKAQPNSSATAFLSLIRNRGASIHPAMAASGPQDEALARAIMARYGAAGPLNNGSPRYSAQVPGEGRPPPREGVEHQHRRLRTRYGSSSTRDSLALPENRSQATSMSPQPVAVGSSLSAIPQQSERPLTGRQIHEWTGVPTQNASDGSTAVRGHNNETESSTGATPVVLPISPLYATQEDEAQHSNPRTLRNPLQAQTSSPFEGLGNNEAAPDMTYHGNRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK92</accession>
    <name>S0DK92_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424872.1">
        <property type="nucleotide sequence ID" value="XM_023572996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DK92"/>
    <dbReference type="STRING" id="1279085.S0DK92"/>
    <dbReference type="GeneID" id="35394108"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00623"/>
    <dbReference type="HOGENOM" id="CLU_362098_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="788" mass="88340" checksum="8AFE76E82A2336B0" modified="2013-09-18" version="1">MNPCAPTFIPVEPSEDEFSPYEGGSSTPSSTEARHPDQDVLSPRARPRGRTIPSITIDPEGYESMFPALRAVNKVDPLKIRSPKMKTKQRGRRRRSRGKDDRALSSNSVNDERLNIGHQFSQSSEDEEESSNEPPLEYLKPTVYTPRKSLEFLKPDVYTPPASSHNSSSRPRTSASMRPADTRARTRSPRRVWRPPTPHPDGRPRGSRLRRTSTPNQRVMSSAGYSVPPVFPNPTYNHFPSEPPYQMIYPPINYAPRIGPSLVPPMMPYSPLPWQLAPAPWSAHSAQPEVMMDYPADYDSHYEQTDWPSFEGESGMYYAPQPPPNLPPQHFLYYQPESHMRPQIQPYSQYRMHLQPPERSVLYPPSRGSDSQSESRSQPTGSKHEKKASTSSSTKASNSSSGTATNVSDTTTPLRTEFDTIKDQMPVGKDRQLLSTVCRDDSTQEEVKKELRKAADYSKIKGFIPTRQAQNSHDSPRVVRGAKINLKRETTPQEENEARETHKLADPLQNAPRGPSSTRQLPQTFSSTLKQSFNLNGSESGSWSQSKRWTSFATKERQAFQKMMANLRYMSADQSPFVPQSPVELTAFKANLAESKTRKLGQEVKQRLARTNAGVDEGVETRVKPVVKLLRGKKFDDCLSPVFAASNCFSTSRNEPPYGAGWPTLTELKEEGDKRSSRQGRCLPLPRLDLVSRTLSSEVSGAYSSDGAVRNDKRTVQVGSYYLCAVTPEEPSITPPIELQSDETHFIPATLLQSINANEDDAKGTEEDNEKTIGQEREVKAEEKGVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL60</accession>
    <name>S0DL60_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425211.1">
        <property type="nucleotide sequence ID" value="XM_023573502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL60"/>
    <dbReference type="STRING" id="1279085.S0DL60"/>
    <dbReference type="GeneID" id="35393735"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00250"/>
    <dbReference type="HOGENOM" id="CLU_018777_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="861" mass="93098" checksum="C5C0545F8714AFF7" modified="2013-09-18" version="1">MVSFFGLKLGGDRKKSQDKKLASKQIQHLHRNEESVSSTPKDLRRQSNFSRPNLARPGTSSSHLDPPTQWKAPYMNGAGGASSMVDLGAPRAPGMGNPRFHSSDIMLNTRFGNGSSTSLVAPGARPGSPTRPGTAISTKEPENPFNIHFGKDSVSSIPPTPQDEPRGHAEPFEFNLGNEIKEIRNKSPIPTANNGYPSPPPSIVNAERSFSPDPRPSSSRQNVPAAPSLRNPSTAGPMSLPSPAVSVARSDDVWEPQPPVIRNVTAKRDTFTFHTPRRQSFTMDMETRENHKPMVEGLAGNFAGFDFGETVRKGSIGSKSLDTSTEGGVSPTDTNVKPRVLGTARTASPLRTMQSSPSLSMIDTALTRARTASDAMSPLSLVSSLASAAAEEAPRIQTPQPSQQAKPTQQPPKILQPGQLSEPLQAIRPVSPSRSPQPSPLSQPPQQNSPGPSPILSNFPGRSPSPPMVEPHFPRSPPRPLIQTIQPSPQYPTKQYKAYQPPDSSPPTKPLPSPYRSPTAPLPPVPPPRLNPGNRSRSNTPDTAASASPGYMNRPLEPPPRGFRARTDSEPRLGRPLRVPAPLVDRSATIPMVGPGPRSAVGPGFDESGFVRAERLPEPPRTASPFSQQSPMEGEFPVQKGLPRGRRPQPPEMQSPERPFGLEPRKQRRQPPMYPPPRSTELPVADSQLEEVLNQPGTPNWNDFDRAEAHKSAIPAALSPFRTQFARSPTQATDDSLSPRLAQYASSPISDTPPSLPSPSFPSLQKSISSSSENLARTFDMMSDGNYERHEHNSARPLISPVMADFVPPRDRDRSRTRVEAKRAPPRPSPITVPSSLAAGAEPTRVRTPNPVVDAFNPGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLX9</accession>
    <name>S0DLX9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to transcription factor NUC-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424473.1">
        <property type="nucleotide sequence ID" value="XM_023568130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLX9"/>
    <dbReference type="STRING" id="1279085.S0DLX9"/>
    <dbReference type="GeneID" id="35394546"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01061"/>
    <dbReference type="HOGENOM" id="CLU_015973_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="546"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="603"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="644" mass="69038" checksum="1D07F589DAADAD2B" modified="2013-09-18" version="1">MASTGEDDFHQFLDMSSMGTLGDGMHFDFQSFQDGSAQGLMNQARDAPDTIMTDSDNSGLMSTPNTMPMSTSTVQSTIPAHMMTPASDPISSIDAQIQYLQQQKFQQQQRQMQEQQVAFFHNHNHSVPPTPQSLEMPSSGQFYSQAEQIPTSGAYDRSYHQRMKEQDMAFTPLVSPAVTPLDPNFSMDSGYTIPSAYFSPLTSPALHAQNDPSTVYDPRLTNTNNSPIDVDLDRSAAPVTSVLDLPKKAARKKTATKTRAKASIRSSPIVKPQRRKTGPSPAIVSHVLSEVEENNGAFLPMPATSTETSAEENSSVSPEALSEMPPPPIPNRRSTSKSPYIQAQSSNQQTPVSGPVDSRPAPATPASLMKLPASRASKQANGPQEPVVSEHIESLELPESVSGKAMTPVISRSSVQSPSVEPMSRRGSSFQPLPSPVFPKASGSASATASPQLVPGSAGPSARKTPQLAPRSNRKRSTGSVHGSPALLPRISPSIKPLLPGTPGMTPAESAASQLLMSKSNYQNILEGNKVPGVSYPSELSTNLTSKRTSHKIAEQGRRNRINSALQVMAGLLPGGDKTNLADEGDKKDGKQANAQNSKASVVENAIVHMKSLEKENGDLKKEVEELKRRLEGLQGSTDDKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMU9</accession>
    <name>S0DMU9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_01620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423964.1">
        <property type="nucleotide sequence ID" value="XM_023576684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMU9"/>
    <dbReference type="STRING" id="1279085.S0DMU9"/>
    <dbReference type="GeneID" id="35395105"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01620"/>
    <dbReference type="HOGENOM" id="CLU_073620_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494983" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="9">
        <location>
            <begin position="34"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT61883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="242" mass="26209" checksum="49F7D9D7227BB660" modified="2013-09-18" version="1">MRFTFETSALLALLPLALADSLTLYLPSNPNPFSIPANTHATLSSAGVHFAAPLSSANTFVFHNVTPGSYLADVHCPTNAFHPLRIDVQLAEDGEEGIVRAWETYRGNDWGNKGEVVQVKEGSKGRGFELRAIGGKNYFMERPQFSVFAILKNPMILMALVSLVLMVGMPKLMDSMDPEMRAEFEAQRKNSPLSAAMTGQSSGDNPLTNFDMAAYLAGSKPKESTPANNGGNGNTKNQGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMV3</accession>
    <name>S0DMV3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to polycomb group protein MEDEA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_00719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023571929.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1279085.S0DMV3"/>
    <dbReference type="GeneID" id="35394204"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00719"/>
    <dbReference type="HOGENOM" id="CLU_004089_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046976">
        <property type="term" value="F:histone H3K27 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048360">
        <property type="entry name" value="Ezh2_CXC_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040968">
        <property type="entry name" value="EZH2_MCSS_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040595">
        <property type="entry name" value="EZH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21509">
        <property type="entry name" value="Ezh2-like__CXC_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18600">
        <property type="entry name" value="Ezh2_MCSS_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18601">
        <property type="entry name" value="EZH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="8">
        <location>
            <begin position="605"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="737"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="880"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1086"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1044"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT62702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1143" mass="128472" checksum="27AA71407EB32C88" modified="2013-09-18" version="1">MASHHLVAIVAGKPDTIDLTGDSDSDYEPHSLAPLNRNNTTTARFTPNFSISSERPSSTNAPVSPPKLNRSTSSIAASQDRQPSASAEPPRPASSVLKLSQKVTTITANSDDAQSMAKLSSVTASNLASRQVTPTPEMDDSKSTQQSKPASPKYQTPKKQEWDVAAVVQKLTQFRQDIKDGHSRMTSYIIESTKPNERRVMTGKNLFAGLVNKPVPSKKGETMRIKSKEHTKLKNNKREDHYSIVRIQTDEERVPRYRFHHVEIKKNILTPNTMLTFVPHLRDLETSEEYKYNVWLQELEDIDRKSGFKPMSREEKVRIAVRSEFASTVLLYLGTWLDKLSIPGCTRSALIRFMASREPDDAITPRQKSDILNSHRPTESTTPPEANKAAHMFTEAFRRVFHQDQHPSKQIELRDVLLLDESVDSIMETKPTAKDGSSTQHENEHDAVEYWLGTYSILGCLICFSHSCEHGEYDAQNCKRTLSILPRLSDTLKRRRRLPYSAADTVNGNGPLSPLCKRNCYRSSPRPVAASIQRPWDEEDHFILRSTVATADRSKVTKDPFCLVAQLLDRDCSDVFNEYQKLNVSMSPVEPANRSQIRTVSWYDRFKKTLIGDWESHTKTHEHQKRELCEPCNHEGPCTSESCICVQHGVLCEKFCGCTVENCAYKFTGCACHSQGKTCLSKGKERPCICVQLNRECDPDVCGRCGVVERADSENADDEVLHSTGCQNCSLQRGQAKSLALGESQLEGVGYGLFTIEDISQDDFIIEYVGELITHDEGVRREARRGDVFDEESNISYVFTLLDNEGIWVDAATYGNLSRYINHASESDKRGCNITPRILYVNGEYRIKFTAMRDIKAGEELFFNYGENFPNLTKKLLDHKVGGKSDQGKKRSRRPNGEGVARKNPKTDKKKPGKGKKRAQAVLDEDDMLADTLGFAPKPLRKRKKGPFEEDSEEEEYHPTGTDASIMETPSDGDSDFGNSAARLRKRARQDGKGAASSHNGKPRGDLKTRGKRGGARPGSGRPRKYPRKLTSAPMLEHPSASESQDREDPEERQIVAADTIVPASLQRPQPVEINDNMEYINLSEERTEESRLLQNQLEEGNDDDDDDEDQDVVVRSRVDRGVRNRRPTAKLRDDGDWLGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN85</accession>
    <name>S0DN85_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to zinc finger protein GLO3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_04792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023571880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN85"/>
    <dbReference type="STRING" id="1279085.S0DN85"/>
    <dbReference type="GeneID" id="35398273"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04792"/>
    <dbReference type="HOGENOM" id="CLU_023062_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT64029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="478" mass="51060" checksum="9C09F334B18D2BFD" modified="2013-09-18" version="1">MSALASKQQSLKIFEKLKTKPANKICFDCGQKNPTWTSVPFGIYLCLDCSSNHRNLGVHISFVRSTNLDQWQWDQLRVMKVGGNESATKFFQQNGGTAALNSKDPKTKYQSNAATKYKDELKRRAARDAQEYPNEVVITDATDDGAATPAGEPDDDFFSSWDKPAIKRPTPPVSRTGTPPVVGRTPSPFLNSGNGKDIARTASPLSRSSTGDNKPASRITTSAALRKTTTSTGPRKANVLGAKKTTKLGAKKVTSDVIDFDEAERKAKEEADRIAKLGYDPDAEEDPATKNASGSGAAIISPTPVSPSRGTSSSHTRQKSDAEVERLGMGMGRLGFGQIGGPKAAAAPKKNAGGFGSVGPVKAAAVDDSERYARDKFGTQKGISSDEFFGKGAYDPNSQAEAKTRLQGFEGATAISSNAYFGRPEDEPEEEYGDLESAAKDFVRKFGITAGDDLENLTQMAGEASSRLQGAIRSYLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN93</accession>
    <name>S0DN93_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable zinc finger protein white collar 2 (Wc-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424953.1">
        <property type="nucleotide sequence ID" value="XM_023573190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN93"/>
    <dbReference type="STRING" id="1279085.S0DN93"/>
    <dbReference type="GeneID" id="35394015"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00530"/>
    <dbReference type="HOGENOM" id="CLU_024414_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="485" mass="53005" checksum="6A3C20C9298B00AE" modified="2013-09-18" version="1">MSHGPPPPPPPPQGAPHPNNFNNFYGFNLDIGSLPDMTGGQMGADGQDNDLMAMLDNSMLGGITDIPMNLESADDSNMSGSFVNGQSTTEESVARAENQFNTAANNVPGAGPLPAGAFAQMNLAGASTLTEFTKRRNWPAKVVEELRDFLQILDANGRIKYASPSILQVTGYSVEEIQDVFLKDLIHPDDQGVFVAELNESIASGNPLRLFYRFKKKDAEYAIFETVGHAHIAGAKFAPNPNNQSPFCQAVFMMARPYPTKNAGLLDSFLEHKIENERLKRRIAELRREEEAENDEAQKQWLQSQSGRSDMTPSEGTGVSSGTFYRPGSERGMTEADRAALNKALTRENLEGSVAGGRQDSLKDKMARYEGASHTDTIEMLTGLRYIEGERSRGITTGNASPTLIKGDAGIAIPMERDPRTGDKKKKLKTSEEYVCTDCGTLDSPEWRKGPQGPKTLCNACGLRWAKREKKRTSTSHPPTVDQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNM8</accession>
    <name>S0DNM8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable translation initiation factor eIF-4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425083.1">
        <property type="nucleotide sequence ID" value="XM_023573346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNM8"/>
    <dbReference type="STRING" id="1279085.S0DNM8"/>
    <dbReference type="GeneID" id="35393876"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00391"/>
    <dbReference type="HOGENOM" id="CLU_043552_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT63002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="256" mass="28595" checksum="015C833B29299E92" modified="2013-09-18" version="1">MAAAVADTPKMDEQVDLTTIPVDPAGKEDSSDVKDDDKPVTVFHDKDNFNVKHPLQNKWTLWFTKPPSGKGDNWNDLLKEVITFDSVEEFWGVYNNVAPVSELSLKSDYHLFKAGVRPEWEDPQNKHGGKWSYQYKDKRNIDVDRLWLQVMMAAIGETLEDEDDGEVMGVVVNVRKAFFRIGVWTRTIGKSIPGRGEGDVAGGKGRSGEKGKEILLSIGRRFKEVLELPAAEQVEFSGHTDSAHSGSTRAKAKHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPD5</accession>
    <name>S0DPD5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426381.1">
        <property type="nucleotide sequence ID" value="XM_023572217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPD5"/>
    <dbReference type="GeneID" id="35397972"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04491"/>
    <dbReference type="HOGENOM" id="CLU_122923_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40020">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40020:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13084" checksum="607FE03E44338896" modified="2013-09-18" version="1">MPPLLHPKSRMTSSLFATTVAACFLVVTIPHLLPCPVPRARFADGDVMVDENGRRMRWKRKDTNPKVEDGIVQFNDVAGDEAENAQDRARRECPLPKPGGMLGEWLGFHKSDKETGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPN2</accession>
    <name>S0DPN2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="22">3.1.-.-</ecNumber>
            <ecNumber evidence="22">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">FFUJ_04375</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 22">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="22"/>
    <dbReference type="EC" id="3.6.4.12" evidence="22"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426486.1">
        <property type="nucleotide sequence ID" value="XM_023572347.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DPN2"/>
    <dbReference type="GeneID" id="35397856"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04375"/>
    <dbReference type="HOGENOM" id="CLU_001666_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000789">
        <property type="entry name" value="DNA replication ATP-dependent helicase/nuclease DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001170">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.320.10:FF:000001">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048459">
        <property type="entry name" value="DNA2_Rift"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21123">
        <property type="entry name" value="Dna2_Rift"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 22" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="22" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 22" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18 22" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 22" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12 22 29" id="KW-0347">Helicase</keyword>
    <keyword evidence="11 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 22" id="KW-0408">Iron</keyword>
    <keyword evidence="15 22" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20 22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 22" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="25">
        <location>
            <begin position="507"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="DUF83" evidence="24">
        <location>
            <begin position="721"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2 rift barrel" evidence="28">
        <location>
            <begin position="882"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="26">
        <location>
            <begin position="1074"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="26">
        <location>
            <begin position="1177"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="27">
        <location>
            <begin position="1250"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="268"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1525"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="1532"/>
            <end position="1549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF21123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="CCT64405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1578" mass="177070" checksum="667D27D77BDECDE7" modified="2013-09-18" version="1">MPLQKSYSDQVGRTKRLPWQRSRSNPVQQTPRPRALQPVSEVTKNKLNKFQYHPANGESATESTENDQNVSTNRTKDDTTTTPATRLTWQELLEPVGGTEDDTTTSPNDRLLWDNRQDTLYMPALSPMLSRKGRKRARSSSPVSSPVADKSNTPSVNVRKLAQALKSPHADPTLELWDRYSLNGIDNAGSPLGLANPALAQLMVSSSPRPSKPTAGESNLRRAISCGLNWPKRRRVERSTSGIRLSTEMEEMEASKSSMVNALLDTVTSSINGPSDEPREEPQDAPESPSPKKRRIYTTSSGSPRLSKTQARFQTPAQHPAQQHVQVPARPPVQLPPPEPASSDYGDDDFDEFDDDTIMQLEASINTTQLETNPQPDVAVAENSPVSEIDHKTPERFDGKLDEFDDLDDDFFDEAEDLITADSQQVSQAPAATELDDLDDEFGDAFGGDFDFEAVELAATQAAQNCSGDSRKPRTIQRYLVTNVLEGEYTDQYGHARPEKILLIQADNSKDIKTVHLRASWFDTPAHADAYVHIIGDFSLRGQCIVDDGQNLLILHPDQLISATVVADSFGCMRRAVLQDRVKATSPPTPPLIYGTMLHEIFQEALLANKWDLPFLCAVIDRITEKHVEDLYTIKVGIPSAREHLQSKMTELSYWAGAFVSSRPKEDAVVEDRNGKKANMAVTKLLDVEEHVWSPMYGLKGNIDATVEVAMQDGNDIRTLTVPFEVKTGKHANSNHMAQTALYTLLLSDRYDIKIAYGILYYMETSKTMRIPAIRHELRHMIMQRNQLACYVRERSVQLPPMLKSKHMCGKCYAKTSCFIYHRLADDGDGDSSGMNEKFDELVKHLTPHHQQFFIKWENLLTKEEKESQKTKRELWTMTSVEREKKSRCFADVIIEEGSASVDTDNPRINRYHYTFVKRVQVSGFSFLESELSVGEPIVVSDEEGHFALAIGYVTAVKRQRISVAVDRRLHNARIRQPGFDEKDNQIFASIMDVAHEGATQDEATGKIKEAPIRYRLDQDEFSNGMATVRNNLVQMMADDIVGSRQIRRLIVDLEAPRFKAAPTQYIVSDRDSLNVDQHRAIEKVMSAQDYALVLGMPGTGKTTTIAHIIRALTSQGKSVLLTSHTHTAVDNILLKLKADKIPILRLGAPAKVHPDVQDFAILAGHPMKSFDEIKNAWHGTPIVATTCLGINHSVFHERSFDYCIVDEASQITLPICAGPIRMARTFVLVGDHNQLPPVVKNEEAREGGLDVSLFKLLSDTHPESVVNLEHQYRMCEDIMALSNTLIYNGRLRCGTEQLRRRKLEVPRMEALMQRHYDASTINAATPRSFCTAPGPNRCWLYDLLDSETRVRFINTDTIQPPVREEAQGKRIVNSAEVRIVSQLVDSLLTVGIPASEIGVMTHYRAQLFMLKDKLKMFSGVEMHTTDRFQGRDKEVIVLSLVRSNEACNIGDLLKDWRRINVAFTRAKTKLLVVGSKSTLKGSGSDSMLSRFISLMEDRNWIYEMPANALENHYFEDFGTQITATGPTQRIKSPRKKASGKENRRRSPKTARISDKALLKGKLITRDILNEMTNGAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPT8</accession>
    <name>S0DPT8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable ribosomal protein S12, cytosolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425513.1">
        <property type="nucleotide sequence ID" value="XM_023569818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPT8"/>
    <dbReference type="SMR" id="S0DPT8"/>
    <dbReference type="STRING" id="1279085.S0DPT8"/>
    <dbReference type="GeneID" id="35394394"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00909"/>
    <dbReference type="HOGENOM" id="CLU_097347_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="152" mass="17494" checksum="39325741102B9F2C" modified="2013-09-18" version="1">MADEYDAEQAAELKRKRAFRKFSYRGIDLDQLLDLSSDQLRDVVHARARRRINRGLKRRPMGLIKKLRKAKQEAQPNEKPDLVKTHLRDMIVVPEMIGSVIGIYSGKEFNQVEIKPEMVGHYLAEFSISYKPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ10</accession>
    <name>S0DQ10_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable general amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426730.1">
        <property type="nucleotide sequence ID" value="XM_023572644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ10"/>
    <dbReference type="STRING" id="1279085.S0DQ10"/>
    <dbReference type="GeneID" id="35397591"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04110"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF39">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="46"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="558" mass="61462" checksum="DA4B2D331453E4B0" modified="2013-09-18" version="1">MGYQEDPESKAVEAPNVSDTSPGVLIDHNSVDREYGRTVRGLSPRHVQLMAIGGSIGTGLFVGIGGVLSKAGPLSVVLGYLIWGVFFVWPCNLCVAEMCSYLPIRGSIFELAARFVDPALGFAMGWTYFYAGLMLVCVEYSAVATLMQYWVPDINPAAWVAMAMVICVLLNVVAVKYYGEAEFIMASLKVILLFGLLFITLITMCGGNPKGDAYGFRYWKGGKAMQPYHAEGDLGKFCGWWKVVLYAGFTIAGPDMISLSSGEIANPRRTIPRVAKLIFYRLVGFYVFGVLAVGIICSSDDKRLLGAIENSAAGAAASPWVIGIENLGIHGLPSLINFLILTSGLSCGNAYLYSSSRTLYGLARDGQAPAFLMKCNKAGVPMYCVLTVSFISCITFLVAGESSVTVFFWFVDLTTTGLIATYTMMIVVFIGWFRARNAQGMDKSVLHYIAPFNPWAAYVGLFLGVTALIFIGFDKFEPWSTQGFVTSYFCHAYAAVLFIVWKVLKKTKFVNPETADLVSGKKEVDEECKHWEEGGIEENYKRELAAMPFWKRCWERMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ13</accession>
    <name>S0DQ13_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siderophore biosynthesis enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426735.1">
        <property type="nucleotide sequence ID" value="XM_023572651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ13"/>
    <dbReference type="STRING" id="1279085.S0DQ13"/>
    <dbReference type="GeneID" id="35397584"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04103"/>
    <dbReference type="HOGENOM" id="CLU_086099_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495026" description="Siderophore biosynthesis enzyme" evidence="2">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="23417" checksum="3A05F9F57AA3D604" modified="2013-09-18" version="1">MAAKFIAVALITAVPALAKTDLAGCTSYDTVLSNANGMYASRIWYVPDTGELCDFLDCGGGRAPPKTTVPGCPGYVGTATYSPLFINPKTLGGAVPEETGDSPTSTEEDMSESATITAAPTAETEESASATEAETETESESKSKDDEKTSTDKAKDTKTITTLATHATPSASSGAEAGSASASGSDSHSAAHSDSSSETDAAATPASTVSTAGAVMPTAGAFLALAGAAMYAGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ47</accession>
    <name>S0DQ47_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_04208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426641.1">
        <property type="nucleotide sequence ID" value="XM_023572535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ47"/>
    <dbReference type="GeneID" id="35397689"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04208"/>
    <dbReference type="HOGENOM" id="CLU_1189956_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT64560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="237" mass="27044" checksum="A7AF8F8170639D69" modified="2013-09-18" version="1">MNQSPNAPNIGSLLVYRRPIINLSPNFQSLVYDGREKSPMEKSEILPWTKFTFENITNAYGDILEQATNSNRPDEVLEFDCENHSMMVQIFYEAFLKETAISLAISLGKLSISPRFSWFRGTDMYLAFAEAREMKEKLPKRAHQFDFGDEDRVHVLYDANEEIRNPFLATVIVVPSCTWEPDSLVTANRDRQPELGPIEQLAACAKKTNTCLSLILGDKDIVVLQFFKTEAGRMGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQG4</accession>
    <name>S0DQG4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_04072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426766.1">
        <property type="nucleotide sequence ID" value="XM_023572686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQG4"/>
    <dbReference type="STRING" id="1279085.S0DQG4"/>
    <dbReference type="GeneID" id="35397553"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04072"/>
    <dbReference type="HOGENOM" id="CLU_026661_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF88">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT64685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="434" mass="48531" checksum="03270DD1961181A4" modified="2013-09-18" version="1">MSSSGVTGSEQLNRLSCKRCKERKVRCNRVMPQCGRCKPNDLECVYPVRVKRRSARPLIDPALSVDGSNAALSTILDRLQRLEAQTVAGSSSTNGQSIPTPSGDGSEVSSSPVAFSTNGHESSALTPHNSDREIDAMTVLKDAVDQVQELRKRSFGSTAITSSIDIPTDLAKTWVANYFQHMPACMFLGLLDRRIIDLIPDIINLPHIHVDPVILVIYYSIMYHGCSLKASNVTSTSSLGYMNSSYLGCLRAVPSWEREASGTMTDLIAALFTSRVAAEFFDYDLAWRMFKQACEYCQTLNLHKLDSDENNTFFSEAKCDNERRGFWEVIQIDLFYRLILNTPPVITNDIWKVNLPWLDPDSDPLPQGMQTIAFLASSRVSLVIARFFAMLDDPENTTKPEIVAKTEDLCREMQQIFTEWQLKVLKITNKTSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQQ1</accession>
    <name>S0DQQ1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="2 11">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_05107</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 11">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 11"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425818.1">
        <property type="nucleotide sequence ID" value="XM_023571526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQQ1"/>
    <dbReference type="STRING" id="1279085.S0DQQ1"/>
    <dbReference type="GeneID" id="35398588"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05107"/>
    <dbReference type="HOGENOM" id="CLU_033449_2_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000294">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="13">
        <location>
            <begin position="12"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="14">
        <location>
            <begin position="264"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="341"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT63737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="417" mass="45311" checksum="C2645B6953887829" modified="2013-09-18" version="1">MASLGGHSKKHKVTIVGSGNWGSTIAKIVAENTRANKDLFEEDVQMWVYEEDVTITKDSKLYDETTGDKPQKLTEVINKHHENVKYLPGIPLPSNIIANPDIRDAVKDSTILVFNLPHQFIANVCKQVNGHILPYARGISCIKGVNVTDDGISLFSEWIGDGLGIYCGALSGANLAREIAEEKWSETTIAYDPPALDNSRAPTPRTGSPNPTIGELPEMQHKDVRGRTSKTKLTAVPADYPPLDQDCFRTLFHRPYFHVQLVSDVAGVSLSGALKNVVALAAGFVDGRGWGDNAKAAIMRVGLMEMVKFGKEFFGETVHTATFTESSAGVADLITSCSGGRNFRCAKKAVEKGISVQEVEKQELNGQKIQGTTTAEEVNSFLKARGLESEYPLFTAVNAILNGQAKVDDIPHLVQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRS0</accession>
    <name>S0DRS0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425344.1">
        <property type="nucleotide sequence ID" value="XM_023573659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRS0"/>
    <dbReference type="STRING" id="1279085.S0DRS0"/>
    <dbReference type="GeneID" id="35393594"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00109"/>
    <dbReference type="HOGENOM" id="CLU_1415278_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003284">
        <property type="entry name" value="Sal_SpvB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03534">
        <property type="entry name" value="SpvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="192" mass="22245" checksum="B5DDC86841BE00C4" modified="2013-09-18" version="1">MSGADIVRVLTNNGSPETKSVSEPKGDYEVVMYRPRIDNGSLRVERWTSKADPTYVYWRTLSSDNETKNYGDSDGSRILETSNDNSRTFSWMLSKSYDAHGNAIEYMYKQEDAKDLVDASGVLPVWEKNRIEELRCCQKYIKTIKYGNSIPSRDPKSWEVSQWTKDMYWMFELIFDYGEHSHETPTSAESLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSA4</accession>
    <name>S0DSA4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_02271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427417.1">
        <property type="nucleotide sequence ID" value="XM_023573981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSA4"/>
    <dbReference type="STRING" id="1279085.S0DSA4"/>
    <dbReference type="GeneID" id="35395753"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02271"/>
    <dbReference type="HOGENOM" id="CLU_045192_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484891" evidence="4">
        <location>
            <begin position="20"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="317" mass="33636" checksum="0D21260CB0E05D7B" modified="2013-09-18" version="1">MRLSSFIAGAALLSSGANALNILLGNDDGFGSGNLREMYRIFKEKGHNAPATKQSGKGGTSDFTTEGNLTAPSQYDLIPKGAPSVGHDPKDSQIWYYNGTPAACTFVALDYVLPKFANFSVPDLVVTGPNYGTNLGGFVWTLSGTAGAAYAATNRGIPAIAISASNQEVPYFEVKNKTNPATWAAQASVKFVENFIATSPKNGPLLPLGYGVNVNLPVLTKKNQNPDFVQTRFTGNAHVNEAVLDKEKGTFTWANIKPYAAGVNACINGDCALPGETYVVENGKASVSFYTVDYSAPSTEYTKSLIQRVASFISSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSM5</accession>
    <name>S0DSM5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to Transcription factor ACEII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427537.1">
        <property type="nucleotide sequence ID" value="XM_023574123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSM5"/>
    <dbReference type="STRING" id="1279085.S0DSM5"/>
    <dbReference type="GeneID" id="35395880"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02398"/>
    <dbReference type="HOGENOM" id="CLU_065605_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="359" mass="39997" checksum="D843C0079809D74C" modified="2013-09-18" version="1">MPVLDEQHLPHYREASQLHASDSLCPELLTAMSDLRQACDRCHSKKLKCTKIPASSVCTRCAKAGVTCLFSPPTRSLRHPDNAVFNWSMLGLDEPAIEPVPSINLDQFITTPPVSQVTDPPPPPPAQVTEISQLSDLMAGLDRLQTNFPTSQRDHLSARELTEFMKICKFDLGSFLEDLLQRSQKLLHLYPEVLKRLEPEDINCDAPDCIHNAQKEYLLSKSRVPIDQSLIHLIMACHLRLLDIFDMITNHGRMCAHAVPLLPREHEPKFDMPEIKIGSFVAPKISAASMMIAMVIELQHSLSSRAEELEGAVSLAVGNESKTAKIISLQCESLKERASDTLDGLCSLRDNLMKLGVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT07</accession>
    <name>S0DT07_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427652.1">
        <property type="nucleotide sequence ID" value="XM_023574268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DT07"/>
    <dbReference type="GeneID" id="35396008"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02526"/>
    <dbReference type="HOGENOM" id="CLU_1372260_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484507" evidence="1">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="198" mass="22437" checksum="A989FB2628B7786A" modified="2013-09-18" version="1">MRFPIFTSIVFTLTTHSATAYRPWNATIPESFNEECRKVLSTEIDCPYFLRREWVDDGYYLKGERAEAYCSSSCRSSLGHYSADLTAACVNEDIWEENTGPQAALDFSMSLLAAQMILCVADEEGPCLEALYKRERDLCSECGLKVAYLSAMFEFKKPLNISSKQFMCLQKNCAKEPGSFVSNEDGKAKLTKWFNDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUB6</accession>
    <name>S0DUB6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_03024</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428112.1">
        <property type="nucleotide sequence ID" value="XM_023574824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUB6"/>
    <dbReference type="STRING" id="1279085.S0DUB6"/>
    <dbReference type="GeneID" id="35396506"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03024"/>
    <dbReference type="HOGENOM" id="CLU_017633_7_0_1"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF46">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="15"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="13">
        <location>
            <begin position="104"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT66031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="185" mass="20634" checksum="1CCD4EC34BE2A78E" modified="2013-09-18" version="1">MASSQAVVTSPEVATHYQVLGLTPTLLDTQHDSTSLIKRAYHRALLRNHPDKVTNSDPSSVCFTVDQITTALNTLSDPSSRAAYDAALRVSRPSDKRDGSFQTGVENVDLDDLAFDEDQECWYRPCRCGNEHSYEFCEADLEEVSDEGELVVGCLDCSLWLRVHFAVIEDEQQPHPSDKTLKDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUM3</accession>
    <name>S0DUM3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">FFUJ_04557</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426324.1">
        <property type="nucleotide sequence ID" value="XM_023572143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUM3"/>
    <dbReference type="STRING" id="1279085.S0DUM3"/>
    <dbReference type="GeneID" id="35398038"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04557"/>
    <dbReference type="HOGENOM" id="CLU_014815_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120290">
        <property type="term" value="P:stalled replication fork localization to nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.970.10:FF:000003">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="22">
        <location>
            <begin position="606"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="547"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity" evidence="20">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR003033-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCT64243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="644" mass="72107" checksum="E8EF8AC30A3AEF8A" modified="2013-09-18" version="1">MADKQPWRKEDEDEEEQELDENNYKAQKDAILLAIDVSKSMLEPPPPSDSKKADRDSPVQAALKCAYHLMEQRIISNPKDMMGILLFGTKKSKFQDSVEGPSGLGYPHCYLFTDLDVPAAEDIQALKTLVEDGEDEDEVLTPSDEPVSMSNVLFCANQIFTTKAANFGSRRLFIVTDNDNPHASDKQAKSAAAVRAKDLYDLGILIDLFPITRGDGKFDLHKFYDDIIYRDPVGEANMTEVRTSKSGNGLTLLNSLISNVNSKQTAKRALFSNLPFEIAPGLRISVKGYNIVHRQTPARTCYVWLDGEKPQIATSETTRIAEDSARTVEKAEIKKAYKFGGEYVYFSPDEQKSLKDFGSPIIRIIGFKPRSLLPIWASTKKSTFIFPSEEDYVGSTRVFTALWQKLLKDDKMGVAWCITRANAQPMLAAIIPSRERSDHGSGTPYLPAGLWIYPLPFQDDLRNINPPSEVLRSSGELTTQMRTIIQQLQLPKAMYDPLKYPNPALQWHYRILQALALEEEVPEKADDATEPKYKAISKRAGGYLEEWSESLEEESGKVANKKSTKRETDDEDMERPVKKSRGSSEKATGSSFSMAQLKAAIEGGTIQKMTVAQLKDILATKGMSTAGRKVELIERIEEWIEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUP7</accession>
    <name>S0DUP7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427183.1">
        <property type="nucleotide sequence ID" value="XM_023572487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUP7"/>
    <dbReference type="STRING" id="1279085.S0DUP7"/>
    <dbReference type="GeneID" id="35397731"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04250"/>
    <dbReference type="HOGENOM" id="CLU_528971_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="595" mass="68623" checksum="976045C8040EBC10" modified="2013-09-18" version="1">MNLAVNTLRLLFGTDPPTSPFADLDSLCISQKVIHASVDEKDVILHCHLLEHFVSIKPKIDIWAMRHMIDPAAAWTCYINMGVRRLLDWFKASHDGHIDLNRDIPPLDVLLVWHAFLQDPVAWGDFIEESQLLFSRWNPDELLRALDGNRQGSFEPSPECMDRINRVYHEADTCSLMSMSVDYVFSVSPNEMTQEVIRLFSQKRLNHTAMTPRGQQKFFYDFHKAVQRQLDLAEQDVKFSWHRIYVSRGDNERALKPAIQRYRRFFTLEMFREEIGYWQFEYPDHIRFADFDIHLVWRTHKLAPQKYERFCINYFGGLVYMIPDPPENQEVRVSHRNSKDQIYEHLFGEEYALCLCWPCVKGRTDKPAGWRSFRRLTRPVVKTQLAAEMDRRRAAAVSIPLDFAEKQCRKCGSHPRRHCRKKDMTEASATRPITPRRSVSDRVPTPGTSVTSPYTPSRNDPFAVPFRDLGMFPFRSEILDQTRLQSPSPSAASVSVTLEPTQRNRNTDLRTFNRSHNSTPDLTVASTESGDSDIEIGPSYYTLTKTLSMYQISADANEFTPRTGNRNADAATDDPRYVSHVPTSNGPEPGAWLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV33</accession>
    <name>S0DV33_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_03352</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428412.1">
        <property type="nucleotide sequence ID" value="XM_023575190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV33"/>
    <dbReference type="STRING" id="1279085.S0DV33"/>
    <dbReference type="GeneID" id="35396834"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03352"/>
    <dbReference type="HOGENOM" id="CLU_000288_5_12_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="331"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="84"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT66331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="704" mass="79206" checksum="6BFA12A4DB52D20E" modified="2013-09-18" version="1">MSTPTTATATLPHYNPHHYQPSYAHSHTHHQTYQPNPSANFRSTVSNQNILPPPVSSAVSPSHSAILPPPYQLSPLGYSSSGSNGISLTNSNSRSAHHAQEPSPRHDAAYSAGSMTERAPATRAEQPSRKRRRSREPDWGTFYKNGLPKEIIVIDDTPEPEANTSRKITNGTAAAPSDNTSSQVAKKRRREDESGTVQASGYHIKYLESQHSTPLQVSTPAGSSNSSSDRTNSALNTTAPTSLSSNGQYEEGLAPLKRKRTRQQVANEAKRRDVDGLGDFFTYKPPPFPPKKASEVNVQVIHDRHYNKNVKVDDDDGHYIVVPDAELTDKYQIVRLLGQGTFGKVVEAHDRKRNKAVAVKIIRSVQKYRDASRIELRVLETLKRNDAENRNRCIHLRDCFDYRGHICIVMDLLDQSVFDFLKGNGFVPFPNSQIQSFARQLFTSVAFLHDLNLIHTDLKPENILLCNHAYQTFTYNRKIPSSSSTISRQATQRRVLLDTEIRLIDFGSATFQDEYHSSVVSTRHYRAPEIILGLGWSFPCDIWSIGCILVEFFTGDALFQTHDNLEHLAMMEAVVGSRIDSHLVQAVNKMSTRSGGNAASKYFKRLKLDYPTPDTTRGSRRFVKAMKHLDQIIPGNNTFLKNFVDLLKKIFVYDPAHRITAKQALQHPWLKEMAQPDDGTEAAKIRMERIRMEQQAQKHGYVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVE5</accession>
    <name>S0DVE5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427463.1">
        <property type="nucleotide sequence ID" value="XM_023574037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVE5"/>
    <dbReference type="STRING" id="1279085.S0DVE5"/>
    <dbReference type="GeneID" id="35395803"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02321"/>
    <dbReference type="HOGENOM" id="CLU_054599_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41705" checksum="28DA0F2057B313CB" modified="2013-09-18" version="1">MSEPSVRPPEYQAGRVIQLQILEGSSGSWAMSERDISVVVERVITETMAPVMQVRFHDRLAILKVYERRYGTDLRDYRDEHIPCTAQVETAYLSFLKTGAMDAFLKEMDHNEATSEFPRTLAEIREGSNGIVRFEAALWRITDQHFRTEAEVYDRSKDLQGVLIPELYGLVRIVAPGATSASSKQDYQTIYGIFLQHVPGVNLYELIMEEVRPTTQQDWTCLIQRAIDAAYEINKRGIILDDSSPRNIVVEPSTFQPFLVDFAQCFFKDKLIQKRVDSDADAEEGKDWDGDAKFCETAIIFNNSSAIGVPMVRRLNKSCGFTVEVRYPKEGQLLCDIKRRPKPEAKMSESLQHVEGSPEPGIRSPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVK2</accession>
    <name>S0DVK2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Weak similarity to Y.pseudotuberculosis CDP-3,6-dideoxy-D-glycero-L-glycero-4-hexulose-5-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428586.1">
        <property type="nucleotide sequence ID" value="XM_023575400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVK2"/>
    <dbReference type="STRING" id="1279085.S0DVK2"/>
    <dbReference type="GeneID" id="35397023"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03541"/>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05262">
        <property type="entry name" value="SDR_a7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF9">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="306" mass="31802" checksum="9B62AA7674C8F784" modified="2013-09-18" version="1">MHVFVTGSTGFVGSAVVKELLAAGHSVLGLARSDKGVEQLKSQGAEALFGTIEDLEVLKKGASVSDAVIHLAFVHNFADFIGCCAIDRAAITAIGSALVAAGGNRAMVITSGTMMLTQGKLGYEDDEPDMSHPMAAARGASEKVCLDFAKQGVRASVIRLPPTTHGAGGVSGFMGPFVKVALEKGVSAYVGDGQNHWCAGHRDDAARLYRLAIEKAEPGSVFHAVAEESVTVKDIAAEVGKQLDIPVVSIPPEKVPEHFGWFQFGAMADNTASSAKAMEVLGWSPAGPTALEDVKAVVDFTKSHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVW6</accession>
    <name>S0DVW6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein PTH11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428691.1">
        <property type="nucleotide sequence ID" value="XM_023575522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVW6"/>
    <dbReference type="GeneID" id="35397133"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03652"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="372" mass="41640" checksum="A357E790983B29FC" modified="2013-09-18" version="1">MAAHIANRGPQLMAVNITFFAMALVTCLLRCYVRLFMVNGFRKDDWLMVVAMVFFTCYATSSTVGVTFGTGRHHDDLETNQIHTAMMCWWFCYLGYALTMISCKLSIGYFLLRVTTEKIQRWTIYLAMFSTALSCGIFFFVTLFQCHPISYFWNKDQDGKCIDPGVVIGLAALYSVFAVGSDLVFALLPGWIVWNLQLHKRTKYSLIPLLAMGCIASAAVIARFPYLHLLGDPDFLWNTTDIAIWSTIEQGLAITASSLATLRPLIKQIAFRLNLTSKPLSLGPSGYGSSPRTPGPGTPRAFLSREAYTLSSVSRQDGPEKKGSGFDSRQPSDLKLGIKKETKWEVKITKTAMSESEEELHSPRAWRNNNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVZ4</accession>
    <name>S0DVZ4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428820.1">
        <property type="nucleotide sequence ID" value="XM_023575245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVZ4"/>
    <dbReference type="STRING" id="1279085.S0DVZ4"/>
    <dbReference type="GeneID" id="35396883"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03401"/>
    <dbReference type="HOGENOM" id="CLU_647320_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="424" mass="48241" checksum="093889C83AFF65B8" modified="2013-09-18" version="1">MGSGKGGSSWISRSSSSKSLRECLEHKCHKPVGKFGRNKEYSVHCEKHACNFGARCKLSKHSRDKFCAYHSVCAWPTCDTKVLDVEGGNFLYSNIGHQKWYCRDHSCKAKVKDKQCYELPHKNSQYCEEHSKEFKCKNPKCDSDRDGSERYCKKHHCEVDDCHRKTLRLEDHEMAGRDKKKCYRHQHCEASRDCKNYSLWDPDKTPTRLCANHYKCQFLHDCNGFAQGDSRFYGAICTYAPRLDAPTLRTDMVTPTPRNASDILVKEQTVQKSSRTAIPTLIFAKLMPARTLHALMSQQSLVAIATAMDATHLAAVRPETAALHSSPLFADSMGKRDRKMSTTIIPLLLLEQHLARVAGLVAMTPDAFRGHFATSNTIAQHIRIRFRPQKLIVDMKRMITQMIITGGSRDHGITIDRFRVLDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX31</accession>
    <name>S0DX31_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable UPF0047 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428048.1">
        <property type="nucleotide sequence ID" value="XM_023574751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX31"/>
    <dbReference type="STRING" id="1279085.S0DX31"/>
    <dbReference type="GeneID" id="35396441"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02959"/>
    <dbReference type="HOGENOM" id="CLU_096980_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="146" mass="16286" checksum="61A594F61FEE633B" modified="2013-09-18" version="1">MSFFQKQFTLPAKSRGSYLITDQVVSSLPEIRDYKIGLLNLFVQHTSCALSLNENWDSDVREDMSDALDRIAPAEGPKGEALYRHDAEGPDDMPAHIKSALIGASVTIPIKDGKLATGTWQGIWYLEFRAARHQRRVVATIQGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXX6</accession>
    <name>S0DXX6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_13600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429472.1">
        <property type="nucleotide sequence ID" value="XM_023576303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXX6"/>
    <dbReference type="STRING" id="1279085.S0DXX6"/>
    <dbReference type="GeneID" id="35407054"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13600"/>
    <dbReference type="HOGENOM" id="CLU_018316_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000010">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF29">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52049">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="88"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="6">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT67391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="478" mass="53783" checksum="AC20B7E200DA0E86" modified="2013-09-18" version="1">MTKELQADDNVRGGDSFEDAPFVRRSTRLASKPPQQITTQVTTSGPRRNPKRKASEAASELNHRLNSDQLLDEALAPLSLKDVQEWEGWVELESEPAFFNIILRDLGVCNVKAQEIFTIDQDSLALLPQPVYGLVFLFQYLPGLEEETEEPDAIGVWFANQTTSNACATVAMLNIVMNVEGIDLGEKLRAFKESTKDLSTALRGHQISKNNLIRTIHNSFTRRMDHLNADLCLENEASDAKTSTSKRRTAAKKGKRVPPRRKRSNAEYGYHFIAYVPAGGYVWELDGLQYKPHKLDRVPDTGDWTCVARPQIEGRMLQYEESQLSFNLLALCQSPLTAYSQTIAHAAASLQYLHKNTESLLAFNDLTSAEKPPLDIEDESRLSDFNLTKADIMRAHVPDALQEKIKRSNFDSQSAYELHQELVVDVKAAMGEYCSELMAISDDEQRVKGRKKDYGPALHKWMKKLAEKGVLEELIKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYH7</accession>
    <name>S0DYH7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429690.1">
        <property type="nucleotide sequence ID" value="XM_023576500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYH7"/>
    <dbReference type="STRING" id="1279085.S0DYH7"/>
    <dbReference type="GeneID" id="35407934"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14553"/>
    <dbReference type="HOGENOM" id="CLU_027089_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485399" evidence="6">
        <location>
            <begin position="31"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="550" mass="58778" checksum="16E466BF2906C912" modified="2013-09-18" version="1">MARVKSFFESRRATMIAGSLLFVVAVSATANPGAVKRQASATATKTGIDFESLTGCHMHGPTQFCMDGSDEYQIVLEATMTKDPPTSYTDCHSHGSDTYCMNPNGGEVQVLVEGATATTQAAKETAAAKNDEITAVSDCHLSEASLYCMGPSSSEYYVQTTITNTEEYPAQLTSCHSHGEETYCMSDDGEAPILPAEDVESGKADPQQEHCHFHAGVEHCVGGGSEESGTRDCGRKDRDYRIGIRIGMLFVVLVASAVGVFGPILMSTFVPVRSNLVLTILKQFGTGIIISTAFVHLFTHASMMFGNECLGELQYEATTAAIVMAGLFISFLIEFCVQRAMRWQLTKKTETDSAYLSPKAIEKAEMANISIMEAGIIFHSILIGITLVVAGDSFFITLSIVIIFHQLFEGIALGTRIASLGYGQIPLALSHSHSHSTPPPTVERTGTSTVPLWKKLVLASGFAIVTPIGMAIGIGVLNVFNGNDPATLIAIGTLDALSAGILVWVGLVEMWAHDWMLGGELTDASLLTTLLALFGLVCGMVLMSLLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYZ2</accession>
    <name>S0DYZ2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to NAM7-nonsense-mediated mRNA decay protein (RdRP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_03638</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428678.1">
        <property type="nucleotide sequence ID" value="XM_023575508.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DYZ2"/>
    <dbReference type="GeneID" id="35397120"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03638"/>
    <dbReference type="HOGENOM" id="CLU_002184_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RDRP core" evidence="8">
        <location>
            <begin position="108"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="7">
        <location>
            <begin position="1289"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="9">
        <location>
            <begin position="1386"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="10">
        <location>
            <begin position="1475"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1525"/>
            <end position="1553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT66597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1726" mass="193935" checksum="6A9F79E6E3300798" modified="2013-09-18" version="1">MASQKSNRSFHHTLLSTLSLDDIVWDFQVPNLPSPSTLKNANLIKAIALHTDLKECRHSMTLKVQSNTPNRATAEHATDRLMLFSLEAFKPLVFGAAAKEQQPAPDLQPRTRQEVSDYSIKCLRAGIILNGVHYNFYGHSNTQLKSRSCFLMAATKEEISRLIEGMGDFTKMKTVGKKVKRIGLLFSSSKTAMIINPDRCEDIPDIETDDYVFTDGCGLIAPSLAQELARRTRIIFRDSRYRPSVFQLRYRGYKGVVTVDPRMKNQKALLKFRKSMKKFSGGDDYSFAVVEHSKPFSYGFLNDESIILLHALGISKDTLLSKQRHHFNLLSNARSDFRDAFRFLSYVNRTDLAERVLLEGHESVKSQINGQINDELKKMLNKQGGQKCRVFVQKSRLLFGVCDAWDVLKEGECAVKVTLEENGLPHALKNTEIIVIRNPCLHPGDWQKFKVVERPELSHLVDCIVFSTRGRRPAADLMSGGDLDGDTFFVSWDPDLIPSTVSAPALYPGGREPIQFKPITDDDRLVYFAKYQNASLGRVKNLYLDWARVAGPMSAQCQELNRLFSQCVDGNRIRIPDKLCNATKPLPDAPPFILDVLHDDAKEWVRRLAVTQDGDLTGYDFDAIQLLFSREDVAIGEFECVKLAYSWCLKNKTPFESLLHLFDFNILTADQKAWVLAHVPGSATVTGLVQNALCSSGILHPPELQQFHLDYPGIKWKRTYDSSMDRLATFHEAVATNLELFQRTLIVFQPDERLSLAVYIPKKIDRSQDCLIDNTGRLFAFPHSQGPQRQARLSLPTKMQYQLYCDGNVFQLFEKQRGNSWVFISRPGNNDQDYRNVQNGGDRRRRRQEVVDRGGQAEVIASIALDKFSRRLQTHIGRVNRSPITAAEIYVISNRDVASMRNLDLWLEQIDTTETMPLFSEEPKDYSLPSLSDILSPSDPSWLIDVVRGSDMSAVTRLELVQQYQQVFQLARKASDKQFFMRCFEHILANIEEAAVGPKELLNAMLQALSTEPTLAITFTPFLSSSRSDKNQDLVLLLEASLLPILRAFVLSANTMGQLILEPFKSILSAVTPGSLSLHDIADLLELAALTIRSTDLALDLFMECLQPNASRFMVADSKVIGHLLRNMIAIAMDHIEEANNVAKRQQGIYELKLSPKDKKGNLIEIDFRIDTTGTPKKGSHVRLTTASLPSNVLVGDNYSMDAFVVISETGRARFECLHPLPSYFEECSWILEDCGPFVTSKSMIDAVKDLCIYQEDYCGVANIIFGLPSPNIPRPDDSFSRIERFNGSQNQAIKLALNSSLLCLWGPPGTGKTETIVEMICALQTVNPKARILVTAPTHNAVDNVMRRYIQRLQKQPLARKTQPDLVRKVADDLRKYTCDAMAGQEIHTDYKAMKKAMEMVKRSDTIFTTCIGAGIGLIRSEFFDIVIVDEASQQTEPSSLVPLVKGCAQAVLVGDHVQLRPTVNQTALALDFDVSLFERLYTEVKSSKDDGSLRTLMLDTQYRMHPKLCEFSSGQFYEGKLKSGISSSARPPTKSDFPFPPARVTKQKGGSEIGMGDHERAIFIDCDAKEMPGQKSKENRGQANLCLHICQLLTKHPDSETPTHSIVVLTPYTRQAEVLKRMLSSIPYKIEVSSIDGFQGREADIIVFVTVRCNEHREIGFLKDMRRMNVALTRARSALIVVGSRVTLTEGTADEESAVLWRKMLGSLAEVKLDIPVKDTLKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ00</accession>
    <name>S0DZ00_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to GPI anchored dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428688.1">
        <property type="nucleotide sequence ID" value="XM_023575519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ00"/>
    <dbReference type="STRING" id="1279085.S0DZ00"/>
    <dbReference type="GeneID" id="35397130"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03649"/>
    <dbReference type="HOGENOM" id="CLU_027719_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF2">
        <property type="entry name" value="ANCHORED DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485073" evidence="2">
        <location>
            <begin position="21"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="157"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="390" mass="42057" checksum="CD5F328758B12081" modified="2013-09-18" version="1">MVSFKSLASAGFVLAGLVSAHPGEKHDHQKIKRQIQTRDTIANLGQRSLNACSSSLHARELKARSIARRAEKVEKLRKRLGIKTDAKKHRRDEDDIVKWEAVNHNKTGVSSNNMFTPLETVFGANSSCILSPEITAGPYYIVGEYLRSNVIETEFCDGVPLFLEVQYVDVATCNGVPNLATDVWNCNATGVYSGVSSQAGLNTTFLRGIQITDHDGVVQFETIFPGHYEGRATHTHLLTHANASVSSNGTIQVYNSPVQHIGQLFWPEDLREEVEALAPYNTNTVEVTTNEEDMWSVLQADESYDPFPQYVYLGDSVQDGIFAWIQIGINTTADYTSDEYYGVAGYLASDGGHALDSGIGGGGGGGGQGGQPPSGSGTPPAGQPTGTRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZP5</accession>
    <name>S0DZP5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_13055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428968.1">
        <property type="nucleotide sequence ID" value="XM_023575696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZP5"/>
    <dbReference type="STRING" id="1279085.S0DZP5"/>
    <dbReference type="GeneID" id="35406511"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13055"/>
    <dbReference type="HOGENOM" id="CLU_045192_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485449" evidence="5">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="297" mass="31724" checksum="E2A13800B8840C07" modified="2013-09-18" version="1">MKSFVSVAILPLAVQAVRIVQSNDDGWAESYIRTFNDALNSAGYDVVLSAPAENKSGSSSRDERPKDRTTACQYDSCPANSGPVGHDPKRPDLNWVNSFPVTAMKYGIDTFGPSLWDGEAPELAVAGPNVGTNLWLQVPFSGTVGAACYAAHEEGIPAIAFSGASTGNTAFNTSPVPKRSLVYAELATTLVKKIVDSGKPYLPQDVYLNVNFGKVEGKCTDASQFQWVLTRINTGLLSKDDTEWCGEDRLPTETEIALKSGCYASISVGDAADKTTADAARQKVVLGKLKDMLVCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZR5</accession>
    <name>S0DZR5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429976.1">
        <property type="nucleotide sequence ID" value="XM_023576723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZR5"/>
    <dbReference type="STRING" id="1279085.S0DZR5"/>
    <dbReference type="GeneID" id="35408134"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14754"/>
    <dbReference type="HOGENOM" id="CLU_017444_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="199"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="521" mass="58831" checksum="F6C5AD5868F1622E" modified="2013-09-18" version="1">MVSNLVDFQVGAAGLGIGAFGGLIDAFTACSKIYGLWKSLRGLDGYLGLLRTKLILQEALLDQWQRDWLDQPTSRRIDIQKQRILQRHKDAVLASLTTVKILLESLEPLREASGSELALERLKLVTGGAEEHDKTLVQISAVLSDLYRLLPTRDPNIALSQTVLSLEHIGNNQQVLFQDSDSTQHVIQPDKLKRAISFRQLGYDLDQDLEKRVAAFKNSTGDADLTIRSDRVKVLKDDDVAGGLRSFGTLDSKTPVVIEWKRYDLTWKGQKGIRLRGRIQNIARLLHADAKPQELLTLNCLGVFEDIEKTRYGLVFDYPLGTSEQTDLVSLQALIKSPTPETLPTLGDRYRMAYTLSLSLAILHASGWLHKSIRSHNIMIPVRRNQPVWSQPYLVGFEFSRPDSADETTEKPEQSVRFNLYRQPSAQGIPGESYRKGFDIYSLGVVLLEVGLWRVAWSLRRDDENPAKFKEVLLSRVDDRLAHFMGTEYQEADEIIRRTASKMICIEALKRLVRGQEVVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZU7</accession>
    <name>S0DZU7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to PDR16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429013.1">
        <property type="nucleotide sequence ID" value="XM_023575751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZU7"/>
    <dbReference type="STRING" id="1279085.S0DZU7"/>
    <dbReference type="GeneID" id="35406560"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13105"/>
    <dbReference type="HOGENOM" id="CLU_014001_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="117"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="349" mass="40267" checksum="0437E692528FD52A" modified="2013-09-18" version="1">MASSTENTAGPRKTPIASPGPNSKPLPRPELTDEQKTKYEALLEQVKGITEIQCEKKADEEDKSGPITDHERSWLTRECLLRYLRATKWSVDDSAKRLKATLAWRREYGLEGFTPEYISPEQETGKQMIIGYDRQGRPCQYLNPARQNTDTSPRQLHHLFYMVERVTDLMPPGVEMLSLMINFKPSKERKNTSVPVSVAREVLHILQNHYPERLGKALIINVPWIVWGFFKIITPFIDPVTREKLKFNEDMKQYVPPEQLWSLDWGGDMDFEYDHETYWPALNELCRQKRDEKYRRWEAAGKEIGESEDYLAGGTDVSVKGFKFGEDAGVKDVQEKLAETKLEEQPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0J3</accession>
    <name>S0E0J3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to multidrug resistance protein fnx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_13358</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429248.1">
        <property type="nucleotide sequence ID" value="XM_023576035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0J3"/>
    <dbReference type="GeneID" id="35406812"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13358"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="78"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT67167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="571" mass="60691" checksum="9DA69B7E2DDBC712" modified="2013-09-18" version="1">MRESASGSAASAVAENGTNALNDERTPLLKSTSQSQNQDAEPPSEAQGDGPDRGLPAGQEEETTVVAEEVSTGRLVLIFGTAWIGVFLGAIDSTIIATLSGPISSEFQSLSLLSWLATAYLISNAACQPISGRLTDIFGRGPGLVFSNIFFAAGNLICGLARDQTTMIIGRVVAGIGGGGLMSISTFLGSDLVPLRKRGIIQGLGNICYGSGAMLGGVFGGLINDHTSQGWRLAFLIQVPPVLVSAVAVHFLVRVPPKQSDKSFLARIDFMGAFLTSSFLVFLLLGLNSGGNLVPWTHPLPLTTIPLAFITFGLFLFWESKARQPIIPVKLLLDRTVLNACLCNLACTMAVMGALFYVPLYLQVLGSSATQSGIQILPSPIGISVGSLLSGFIMKRTGKYTKLGVVGLLFLIAGVVVLTIQNEHSPKWLMGISFFLIGSGYGATLTTTLLACIAAVDHSQQAVITSATYLARSLGSTVGVTIGSAVYQNILKARLWDRFGAEPGAADEIRRIRDDLDEIKHLPEGWYDGVISSFVEAFRGVWLTLLAFAVIGLLCISLMRQHTLHSTLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1E9</accession>
    <name>S0E1E9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
            <ecNumber evidence="15">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_07307</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430600.1">
        <property type="nucleotide sequence ID" value="XM_023577544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1E9"/>
    <dbReference type="STRING" id="1279085.S0E1E9"/>
    <dbReference type="GeneID" id="35400784"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07307"/>
    <dbReference type="HOGENOM" id="CLU_008523_11_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005146114" description="Carboxypeptidase" evidence="15">
        <location>
            <begin position="27"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="478"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="559"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT68520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="618" mass="69239" checksum="96BC848A6D2A0157" modified="2013-09-18" version="1">MVLKFMIPSPRRWAALVSFCLAPTLAIAVGDATATKAAAADYYVRDLPGLPTDGPDVKMHAGHIEVTPDTHGNLFFWHFENQHIADRQRTVIWINGGPGCSSEDGSMMEIGPYRLKDQDHLVYNNGSWNEFANLLFVDNPVGTGFSSVDTNNYIHELKEMADQFVKFLEKWFALFPQYDRDDIYIAGESYAGQHIPYIARAILDRNMKNPATAWNLKGLLIGNGWIDPIEQYPAYITFAIQKGLIKKDSDEHKQLQGDLRNCQRMMASDVGHVDYGECEAILSNMLRLTKNGDGDNACVNMYDVRLKDSYPSCGMNWPPDLVHLTPYLRKPEVTKALHVDGIKKSVGWTECNGAVGGAFNARKSKPSVDLLPALLKEVPIMLFSGAEDLICNHIGTENMISKMEWNGGKGFEVTPGNWAPRRDWTFEDETAGFWQEARNLTYVLVYNSSHMVPFDLPRRSRDMLDRFMGIDISRVGGDPADSRIDGEKGPKTSVGDAKNSTKTADEEHQKQLDEAKWAAYYKSGEIVLVIVIIGVIVWGYWIWRERRRGAAYSALADHDLSSRSNGHRPKSQPGDLESAAFDESELDDLHVTTPGTSNSARFPANHDSSEKFVTKYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1J9</accession>
    <name>S0E1J9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430640.1">
        <property type="nucleotide sequence ID" value="XM_023577590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1J9"/>
    <dbReference type="STRING" id="1279085.S0E1J9"/>
    <dbReference type="GeneID" id="35400825"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07348"/>
    <dbReference type="HOGENOM" id="CLU_029957_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013243548" evidence="3">
        <location>
            <begin position="16"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="407" mass="42541" checksum="A97719CBCF0EC29C" modified="2013-09-18" version="1">MKLLSCLVFVPLAVAHNPRQYEALQAAPGDLMPRFFIDRSFPLAKRAGDCGSNHHNCLEVGFPDDCCDNDSYCYVNRKGDPKCCPIGSNCSSDSPCSSNAYFCTRTVTRSGTATAQEGCCDRKCPRTSLYLCPSSLGGDCCGYNSECREGGDCASTRPASRTDLLSPIPSGCTTSQHKCSDGAGCCDNDQECTQVSGNGYCAQATPTESGVTIVDDDDDDNGDGGLSDGAKAGIGVGVVVGASIIVGGLIWMCLRKRRQRTASRPSASGEGEGSAPPRDAMTDISGSHARSGLTQDYFGPDPAAGPYTEQASSRVTSPGRTAAVPMHAQSPGDIAAPVEIDSANRDGSDLLSPMSSPSIYQTPLSETIDGRFELYGNDSAITPDRPLSIVPTPPQSVAGDVVPKQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1M5</accession>
    <name>S0E1M5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to salicylate 1-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429648.1">
        <property type="nucleotide sequence ID" value="XM_023576743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1M5"/>
    <dbReference type="STRING" id="1279085.S0E1M5"/>
    <dbReference type="GeneID" id="35407841"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14390"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="147"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="413" mass="45930" checksum="57EAE3DD2A6720B3" modified="2013-09-18" version="1">MPGRTETSLSIGIIGSGLGGLSAAIALRRAGHQVTLYERYDFGGEVGASLSVASNGSRFLEEWDVDIPAAKPVILRNLIRHDYSTGEVEGTYPLGDYRERFGTDYNNFHRIDLHNHLKDTALSPSGKGRPAELKTWHRASKLDTETGHITFENGNEATHDAIICADGIRSVMREQLGVIPNFVPSTSCCYRCIIYADKLRELGLEEYINNEAIEFWGGDTKTKIVLSACSDNNVVSCYCFYPAEKNDTKEDGWNISTTGDVLASTFPGLDPKLIKLFLNAEDIKMWRLYNHDPYPYWTKGRCTLLGDAAHPMMPDQSQGACMAIEDAGALGILFSEKYSDLSVEQRLKLYEAERKPRATRLQEASKRARENLNERIGWSSKNTKPGMLTIDEVCAYDMHAHIAGLVNDTQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2H5</accession>
    <name>S0E2H5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428959.1">
        <property type="nucleotide sequence ID" value="XM_023575686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2H5"/>
    <dbReference type="GeneID" id="35406502"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13046"/>
    <dbReference type="HOGENOM" id="CLU_776225_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="357" mass="39911" checksum="F577601D0988EEB9" modified="2013-09-18" version="1">MATWKVLPSNADRGTKPSILVIALQLQLAFSATCNYHHCAGTHTPLPFYATTRSDFPARLDMSSYSHSREEGRDPRGDESQYSSYGDDNVAPRLRRGLNHAQRTSLQLLDAQKESSERIRELEDNNHSLQEEVANMRAQLSFATGTIINEIQDKVDTATFAGSTVHSLKKQVADQTDTIQQLKTYNKRLITEIVRLNSQSKKKRKSSKSSKIKKEKPDHHVEPFDADAAATTPSPITATAQAPAHEPSAQVCEPYVITDVMRERLIEDGHLTLSVMAQFQQALSKRNNEGKNLFEFIHQGRTGRYYCFHEVCEKGPRASVEQRLANGGCKLGSDKCNFLVKAVSVGSHRKLQIYNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2R3</accession>
    <name>S0E2R3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431060.1">
        <property type="nucleotide sequence ID" value="XM_023578215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2R3"/>
    <dbReference type="STRING" id="1279085.S0E2R3"/>
    <dbReference type="GeneID" id="35401387"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07910"/>
    <dbReference type="HOGENOM" id="CLU_027580_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF1">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE GLYCOGEN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="386" mass="41703" checksum="C076A5A1C953BECB" modified="2013-09-18" version="1">MGFQYELDGSVETHDPSLPSTTACPYLPGQTVNTLIVPVEQALRQRSASLTSMRATDLKTMNPESKYIAPRPAPSVPASHIPYRVGSSPSLNHKSSSRSLSPAPAAWKRLFGRKVNSEGERGRSPIRNDLSGPAEDIDERCTTPSEGTRTRDISPESLRRFLSDDLPPRPGSNLSERPSLVIPEDVVEDNENDDDDNFATSAASDGQPYVTLRSDAAHSSMLPLIPSKPSRKDLLEVSGVPASAVLPSRPRLETLRAPNPRINPATSFFLSPATPNFPEDEGNNFFDLTDDEDDVVSSSNSDILAFQPVPGMAPTTDSFECYSLPESREQGRKIVESQSAYAKVNSTSLLSRGDSGNFLGAPIDTGLDDFAAELGWMVDVIGSKAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-01-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3H0</accession>
    <name>WOR1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Global transcription regulator sge1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sge1</name>
        <name evidence="5" type="ORF">FFUJ_07864</name>
    </gene>
    <organism>
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="Environ. Microbiol." volume="17" first="2690" last="2708">
            <title>The global regulator FfSge1 is required for expression of secondary metabolite gene clusters but not for pathogenicity in Fusarium fujikuroi.</title>
            <authorList>
                <person name="Michielse C.B."/>
                <person name="Studt L."/>
                <person name="Janevska S."/>
                <person name="Sieber C.M."/>
                <person name="Arndt B."/>
                <person name="Espino J.J."/>
                <person name="Humpf H.U."/>
                <person name="Gueldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="25115968"/>
            <dbReference type="DOI" id="10.1111/1462-2920.12592"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Global transcriptional regulator that acts as an activator of secondary metabolism. Required for expression of a yet uncharacterized secondary metabolism gene cluster containing a non-canonical non-ribosomal peptide synthetase. Not required for conidiogenesis nor for pathogenicity, but is involved in vegetative growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Regulates its own expression in a negative feedback loop.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3H0"/>
    <dbReference type="SMR" id="S0E3H0"/>
    <dbReference type="STRING" id="1279085.S0E3H0"/>
    <dbReference type="EnsemblFungi" id="CCT69384">
        <property type="protein sequence ID" value="CCT69384"/>
        <property type="gene ID" value="FFUJ_07864"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07864"/>
    <dbReference type="HOGENOM" id="CLU_028895_3_0_1"/>
    <dbReference type="PHI-base" id="PHI:3210"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000431522" description="Global transcription regulator sge1">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="25115968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="25115968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="CCT69384.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37758" checksum="8F4F93E77E2F7A04" modified="2013-09-18" version="1">MAGTMPLRPTYVGFVRDTTDALLIFEACLSGTLSHVPRRPHDRERQDLIKSGNIFVYEEHASGIKRWTDSISWSPSRILGNYLLYRELEKPFPPGEKKRARGRNGKSTTQSGGISKARQRNTVPFPQGLEHGNEYPSVPSDDERHLVGSLVDSYDFKEQGLVKKTISITYQGVPHHLVSYYNVEDVKAGLLSGPSDDPRLRGVVPRTELMNGQNFRAPVEEAMGGSYMPSMVASIGYPTLQHQSQMHQSQMHQPQMHQPQMHQSQMHQSQMHQPQMHQPQAHQPQVHQPQVHPPQVHQPQAHQPQYQSQTLHPTHGYQQTYAGQPNAPSSTWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3X4</accession>
    <name>S0E3X4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_05338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431531.1">
        <property type="nucleotide sequence ID" value="XM_023578537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3X4"/>
    <dbReference type="STRING" id="1279085.S0E3X4"/>
    <dbReference type="GeneID" id="35398817"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05338"/>
    <dbReference type="HOGENOM" id="CLU_059964_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF8">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT69451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="225" mass="24363" checksum="7375F3DA0939AEB4" modified="2013-09-18" version="1">MVPVVRIPVCSPELVPHALNAGAGGVIMPHVQNAKQAEDLVRLSRFPPTGDRSYPPAALINEHQHKTPEGQTTYDVWNNHAAVICQIEDLEGLENIEEICRVPGVDGLFIGTGDLRLCMGMATGSLDGDEPAFVSALEKIRDAAKANGLPMMGFGISHSTMKSRIDMGWNAFIIHGDITAICQSAIQTLDSYSSVARRIVSNGHKNGESGNGEYRNGTKREWKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4A9</accession>
    <name>S0E4A9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431794.1">
        <property type="nucleotide sequence ID" value="XM_023578851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4A9"/>
    <dbReference type="GeneID" id="35399098"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05619"/>
    <dbReference type="HOGENOM" id="CLU_076914_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="199" mass="22856" checksum="DBCBDFB7C825BE1E" modified="2013-09-18" version="1">MAPIKPTTLGEQPEKPVPRVPKSPSRTAQIQAQNRRREYLSRHPSYFDNLEHELADPVLYERLVKRFQSASEREAEGKAKGYGRTLEADLQRGELKLSRLKDGDIENSGGDLEHPWEKPAADKAHGLLLWHAFLEERFVHGLDDDFDYKPVDADEDLDTMIRRDAQDAWFDDEEPSWIDEDESSAQLPTRQGETGVQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4G4</accession>
    <name>S0E4G4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429674.1">
        <property type="nucleotide sequence ID" value="XM_023576474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4G4"/>
    <dbReference type="STRING" id="1279085.S0E4G4"/>
    <dbReference type="GeneID" id="35407910"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14529"/>
    <dbReference type="HOGENOM" id="CLU_121100_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="148" mass="15760" checksum="616BDA44037C1CAD" modified="2013-09-18" version="1">MEWTKATYNEQYEKWVPWMEDMYLRWFTKDNKTSYAAKQNLDKTKVTGVEQVDTLQDGVHNLAAGQVGQGGLLQPVGDLASKEGVNRAERQGRDENGGYVNKDIPGSGAMNSTANAVVGGGQGAAQGLQDVGKGVGNTVGGLLGGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4T5</accession>
    <name>S0E4T5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor IWS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_05579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431755.1">
        <property type="nucleotide sequence ID" value="XM_023578805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4T5"/>
    <dbReference type="STRING" id="1279085.S0E4T5"/>
    <dbReference type="GeneID" id="35399058"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05579"/>
    <dbReference type="HOGENOM" id="CLU_045275_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="244"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT69675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="428" mass="48567" checksum="EFA1EEA3C87BDAB0" modified="2013-09-18" version="1">MSERDSPIGEHANEPVNDGQEQEYEDAIAAADSDRDSDALSEVDEDQFEDYDPETANIEDRPVDIDEDVARTLKATKRKRADGEAPKKPREGRRDKKRRDRDEDVDMDDAEDGGKKSRRSRRAAGDGERRQRSKPASPEPEKEENLTPAERKQRELDRMIDAAIKKPSGLKRRKKDEIDLEDEIDDLLADLKVQMEQACQADNQAREAGQPALHKLKLLPEVTAILNRNNVQHAVLDPDTNFLQHVKFFLEPLNDGSLPAYNIQRDIFNALAKMNIEKEALLSSGIGRVVVFYTRSKKPEPSIKRIATRLLGEWSRPILKRTDDYKKRQIETRDYDYESAKMAQRQKTSSQFSLSQRPAVNAKDAERERLLAPSRGNNSARMVNLPSSYTVAPQSTFMGSQNSSHRPLGAGGMEAFRKMAQKSKKRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E577</accession>
    <name>S0E577_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430942.1">
        <property type="nucleotide sequence ID" value="XM_023577964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E577"/>
    <dbReference type="STRING" id="1279085.S0E577"/>
    <dbReference type="GeneID" id="35401161"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07684"/>
    <dbReference type="HOGENOM" id="CLU_064787_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="192"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="270" mass="30579" checksum="37D94FD60B9713CA" modified="2013-09-18" version="1">MKHNNNVRLLAVLADPESDEKSEYRFLVDGAHVRYVTLDGGLIDPEHRTYEPKLLPQLPVFPSGDWNEGRVGKDGHTGKPFFCETRRSSLPGIGNVWHDVMIDHLELRQIERVRQTLYRVSHPAFKTPVLAKFAQFPWEIPFFAAETTSYEWIHGQGIGPEFLGHIHENRRVIGFLLEEIHNARTAEPEDLATCQSSLQKLHDLGIVHGDINKHNFLIRQDGDAVLIDFETAYKCTDPDVLDEEYRHVKESLEDTSGRGGAGMASDSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6L7</accession>
    <name>S0E6L7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432545.1">
        <property type="nucleotide sequence ID" value="XM_023579767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6L7"/>
    <dbReference type="GeneID" id="35399919"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06442"/>
    <dbReference type="HOGENOM" id="CLU_973329_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="286" mass="31289" checksum="73D9F2023BF0896C" modified="2013-09-18" version="1">MSLIGFSIYSIVMGGKDMSVAQIGRATTDVTKGIFDILTHFLLRTEVNNSFESNVYDSNLEDLAKGGNKNASRETTCVAISIVVIAFIIWDLCNQWDKLSGAGRGLATEYIAILVAAVIVGIIGLFSTCAFIPVIGQVILVVGLIISFFSLVYGRPEPEKTPGEKFVDNMRGYNGWLEKIDDPPSTALECAITPTEIPKDAGFSFQITGKNTKGSSTQFIIKPNTEKLSSYTKALYIKFGFTTGYYTVCLFSNESFSTAPDAKNGKYTYSGPDDPFQTMLRAEWQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6P5</accession>
    <name>S0E6P5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to sugar transport protein STP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_06821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431497.1">
        <property type="nucleotide sequence ID" value="XM_023577003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6P5"/>
    <dbReference type="GeneID" id="35400298"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06821"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF44">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495645" evidence="9">
        <location>
            <begin position="27"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT69417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="549" mass="60252" checksum="BA01D9F8838B0CFA" modified="2013-09-18" version="1">MINFHVWRHVPGKALLFLINLVASTALIFEGYNQGVLGTVSETPGFIDMAGIGSNGVVTNSTKQGGLAAAYYFGGMWGCFTGGWVGDKIGRKRGVLVGTLFGILGAALMAGSINSNMFLCARIIAGLGIGFLNAIVPPWVSELSEAHDRGSSFSLVFVSNYLGIAIAYWLNFGLRNANTEFRWRFPLAWMAIPLIIVDIALPFLPESPRWLIANGRREEAVDILCKLRGDLTRDTPKIATELAQIDSIVEATHNRRNELLNIALGGRYSGNLHLGRRAVMGFALQWIQQWTGILAIAAWAGTLFNLAGFDTHKSIWLAGLANTFGIPGTVAASFVIDRIGRIKSLMVSFVTQGIALTLVAAFIKTSQDMAATDSEKSQQLGTAAASFVFVYIWFFTMFNIIPCWIYGTEIWPQEIRAKGYSFTIFGWACGCGMTQFVIPIMLQRLGWATYIFFGAMNVVAMPLVWFFFPEVSKKSLEEINLLFTSNSLLVSKNMEEYERRLAEAGGDVAVASRQLLDEVDGYVQQVRGTEKDLENCGNGTIEQQDVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6W3</accession>
    <name>S0E6W3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432509.1">
        <property type="nucleotide sequence ID" value="XM_023579724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6W3"/>
    <dbReference type="STRING" id="1279085.S0E6W3"/>
    <dbReference type="GeneID" id="35399880"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06403"/>
    <dbReference type="HOGENOM" id="CLU_1602854_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18366" checksum="68F1D6625E05FE17" modified="2013-09-18" version="1">MPWKKKLILSLALGMGVVRFMRPFILDIDYQITHNLTSVEGNLIIIAACIPVLQPVLEMLKGRNIWSTKKGSGKHHDEDYSKQSGQQQPGIELKDKPRKKLDAYGFTIQGKEGSEENMVDADKVSRITSSRPESPKEGIVRTDQVTIGYDGGEGGPTSAAKRWATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E782</accession>
    <name>S0E782_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_06129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432843.1">
        <property type="nucleotide sequence ID" value="XM_023579419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E782"/>
    <dbReference type="STRING" id="1279085.S0E782"/>
    <dbReference type="GeneID" id="35399606"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06129"/>
    <dbReference type="HOGENOM" id="CLU_045161_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904600">
        <property type="term" value="P:mating projection actin fusion focus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="273" mass="29828" checksum="4F754BFCD46DE037" modified="2013-09-18" version="1">MSDLETVSAFVEGAPPGELADVIADIKSLTLETSPDIISSLGPAFEKYNEEQFVTVKLPGSSQPVIISSHNSFGDGRYYDVESSSSFAFDHTTQKASAVQSHVLEGAQADLVKSTLKSIGPYVDEHFANAAHGVYPIESDSKIAIVIVGNKYSPNNFWNGRWRSLYILDPSSGALEGSLKVDVHYYEDGNVRLLTNKPVSSTVSSVNGASIVREISTTERKYQEELNKGFVSLSEGAFKGLRRQLPVTRQKIEWDRVTSYRLGQDIGGGSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7N8</accession>
    <name>S0E7N8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to ankyrin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_06660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432749.1">
        <property type="nucleotide sequence ID" value="XM_023580011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E7N8"/>
    <dbReference type="GeneID" id="35400137"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06660"/>
    <dbReference type="HOGENOM" id="CLU_001836_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="383"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1124"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1236"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1300"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1344"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1473"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1612"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1716"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1799"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1722"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1810"/>
            <end position="1837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT70670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1847" mass="204559" checksum="D9CF4C60D2A16041" modified="2013-09-18" version="1">MSDSESVSGSSSGDEVLSRRSSVQHQDERQVEHIDSTENSNKQIEERCGNIRDEAPNFELTQPTVADTKGEVLHLVWQESPPDSDTSDQATEARLIDFIAIPGVYANWTDKDFGPSPGSGSSAWVTKYAEEGWEKPKNAHSSCRVFRFDYDSSELFSGHKSREAIHRVALRLLNGLRSKRAGEIKKRLIYFISHDIAGAIVKDALITAFLDRSSWQDISEMTRVLIFNGCPHRQRDTADLETRLANFLYINYSQDSGKPRPSLTSISGITKAIMQVNGLFVTSHIALRSWIINLHSHGEDGSGSFDAYSATLGIPQERRLTAPTGTDYSPLTQYLAKIEPDVREPKESIGTRQFAQERKLLALASPIYPLRNKVQPNPLADLPAYQSWLNSPCPQILYLHGSHRVRDVAESVFYALEDEATKAKRRANVLFFSFDRFDVRADSIRDMIATFLAQICNHHPKLGPAINRLCSQIENERGWTETDLIQFFEMLRISAEVEQTMIVINHFDECTKGSRKRFLDHITDKYYNDETPWKIVVTSHEPGALSEELSGPFCVPIDISPGEFGDLDADGFENDIQALIGSRGDLTFREEQIHVELRFMEKLDPPVRHILCEQLRIREEWPDEMSTDDAIGLLGLPKHVAEGDKAMVSVLNAVLKQNTDPKSLECLFSWLLYAVRPLTIWELATVLWFSDEREGNKVSPSFMAVDRLVEKIEKDLTGILEVDHNEVRFKHPCFHEIMVNGDASTQNAEDKDCLWNKIKGKAHHVIQSMCLDYLSRDAVQEYVRETFAVTDSATFETPPFPDRTNLTSYAIQAWAHHYSLSSPLPDISTLSSKKDLVQTLAKAQWCLSNPTTRRSPCFQSLFPIFAGLGLPNVVEPLGSDDALRGLIEAASRGQKQVVEDLLREYDFTPDETWDVLKAASSSGNEGLMNVLLAKIEAKGKIPDNFQWPPVLIYRAANLGLAGFAERILSLGCPADPDVDWRNEISMQASPLYQAACHGYTSTVRILLKHGANVEYTSLSGRNPLHKAALEGHIETVKAILEESQVNIDCASESNFTPLYLAVLGGNHSTVKLLLEKGADPNMGISDSHTGDDQWTPLHAATDDGFMKCIRLLLDYRANPNIPGPSGPPLHWAVTHARVDILNMLLDAGADSLTKVLKKPLSVTSVGSELWEAGLGMLKRLLELKLDVNYKDGEGSTPLTTLICSYANKPAGESVQRDKALRMLIDHAADVNLASDDMWTPLQYAVIMKQYNAVEMLLEAGADPNIAYKENQAPLCSALEQPKIARLLLEKDANPNVGFSRGFTPLTYAACFGHQDAVEVLLEYGATVDLEYGFGVDEPFNDWLKGWTPLMCATFQGHHGIVQMLAEAGAEMSGRDKETGRSIVHIAIFGGTLSTILEFPSRIDLNATANDSLGALHYRDLKIQDLKRLVNAGADIEIGTGERPTPLHVYADCDFEKVKFMVNRGANINSLCPHHGSPLHQACRAGRFDIIKFLVEHGANVNATEDFLGTPLQALFLSQGPIDALEHENIVRYLLSQHADVTVKAGIWRYAINSAALGSLPSIISLVLDQENATVDVKDDMGRMPIHLAACNSLANFEAILERGGDIHAKDKQGRTPLHWAAQTGKLQVVKKIISLMGAKLDVDVTDIDGWTPLCWAPRYGLPLLKPENVGELSLSADVVRLLIEHGAKRDVIVKLGEEMWTPLRISQYHRSNPDVVSVLDSRGSTDTGNSDDTPEEAGTKSKAASKTGVQQGDSYCDYCLSRIYGLYWGCDTCQGLCFCHKCYQHAGILHPGHADYTQKGEEEYEGGEQDISATTTSGSSDTYSNSESDSDSGSNHSEAGEDNEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7S0</accession>
    <name>S0E7S0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_07285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the wetA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430578.1">
        <property type="nucleotide sequence ID" value="XM_023577520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7S0"/>
    <dbReference type="STRING" id="1279085.S0E7S0"/>
    <dbReference type="GeneID" id="35400762"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07285"/>
    <dbReference type="HOGENOM" id="CLU_020420_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF25">
        <property type="entry name" value="DEVELOPMENTAL REGULATORY PROTEIN WETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT68498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="621" mass="67171" checksum="FDC8EC258E0D003E" modified="2013-09-18" version="1">MASWTLPYRVEAVDRDPGFYWQDIDNGPNDGSNDFFGQFLNFDGEIPSSMADPHGHNPSMPALANGLILDHPAESTASASSGVSTTEDEFDFFSCSSQVDATIPSQPASSAVASASHEVDPRSLALASAVGLTDEKPPLVPRVSMSDPELPRVDGISLHSSPGKRVPISQPSSPTPPNTMARKPNKFVEALSSTIRKASKLRKPKKLVAIDRPGSPTMDNPPRALRLQHHEYSNGNDAFPPSPTCRPDSTNFVHGLCDDPFSEIPQPPPNNSLRFFSANGIHTPAESPGVKTEPGLYHPDMAGQVPQSAWQHQQHPHSHPHPHQHPHPHPHPHPHPHPHPHPHPHPHPHPQAHVHPNPHQQPVTVVGAAPETWPGQEYMAQNPHQSGWWDLNLLNQNGEYAVADPQQQKNASLNLAMHAQHAELPYEYQIHDPNSAGLMIHMPQPRNASAPSHDLSLNTQTYLPPPPIPPTSERHRPPRAPSSGARHLSCSPIRKTRQPSIPPTPATAHSRHSSNGSVASARSASGRGIVPGTPTAMRKQRRSRDASGSSGGGSEIGFVNFTPSDGGLLMTGVAPSGSSKTKARREREAMERRRRLSEAAMKAVQAAGGDVDKLMEQGFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7Y5</accession>
    <name>S0E7Y5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432849.1">
        <property type="nucleotide sequence ID" value="XM_023579587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7Y5"/>
    <dbReference type="STRING" id="1279085.S0E7Y5"/>
    <dbReference type="GeneID" id="35399756"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06279"/>
    <dbReference type="HOGENOM" id="CLU_035351_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="39800" checksum="278D7FF149C3504D" modified="2013-09-18" version="1">MNAGTGRAGVISAPDDAAPMDKLAHAVLDDVLYNVLSDLLMKTHREEKTARATTAAIRIEKLASDASDSSTPDSKPDVRIETDAAIYEDGKVLLKGNPLKTTAEILCPRCHLPRLLYPTDGKGAQKPDPGVIYCKKHPYIDKPGCDIYGQSWVPQGPGRGKKKKDMEKNNTDSPNTEQRPPNVLSFPSATCSKCKRCILVTRLNNHMGSCIGNSGRNASRAAAQKLSNGGSQNDTTPPSSQKATPAPGSRAASPKKRDASDEEEDSENSHKKKKLKPTSSVTKKVILKTKPSLKKDKPKGLSSLSQEQKADYSNSESVEVAPKKVVSKGISPVKKLKMNKPPLGSPKPKSSLIREATGESESSDTLSSPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E820</accession>
    <name>S0E820_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433095.1">
        <property type="nucleotide sequence ID" value="XM_023580292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E820"/>
    <dbReference type="GeneID" id="35402424"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08950"/>
    <dbReference type="HOGENOM" id="CLU_1468262_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="184" mass="20053" checksum="2DB3F7A1C05FDFDA" modified="2013-09-18" version="1">MASPSTLMTVTPPTATATATLDALTQHYHGKPNHSDKIVIIGLTVGMVALFLLFIAPCCCMQYLAHRQQRKEKKANACSTATMTNTIHRRMSDTSVVIAIAVSCAAIVVIFFAAICFCHWRSRPKSPTGTRSRDHDDSDANSNVEMDAIPDGSLNHPLVRGRNGAGHVYPVFEATRERHAHAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E838</accession>
    <name>S0E838_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433123.1">
        <property type="nucleotide sequence ID" value="XM_023580326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E838"/>
    <dbReference type="STRING" id="1279085.S0E838"/>
    <dbReference type="GeneID" id="35402393"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08919"/>
    <dbReference type="HOGENOM" id="CLU_038606_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="374" mass="43816" checksum="0A258DC1F353C357" modified="2013-09-18" version="1">MVPKAVFRGILVTGFCSLLWLTFRHLRGSRAVFTESLQSIDLLSPASHHGRKTSELYASRAAHDLCSVHGYSAFVPKSPSSERKVYDMLMINDELDFLEIRLDALYDYVDYFIIVESAKSFQANSKPLILKENWDRFRRYHHKIIYHELVFPSNFDPHRAWDYEDLQRDAPFDQVLLNLNGPRAPNKGDVLIVADVDEIPRPQTLLVLQYCDFPRRLTLSSKFYYYSFQFLHTGPEWQHPQATYYQGHQTLKPTNLRNGDGGFRPFRFLERDVLSNAGWHCSSCFQTIDQFLNKMASFSHRWMNREEYRDKDKIAAAVREGKDLWGREQDQFVRIEDNKDMPSLVLNEPNRFGYMISRDGPSAGFVDYNRKEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8H2</accession>
    <name>S0E8H2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Regulator of rDNA transcription protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_06003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432146.1">
        <property type="nucleotide sequence ID" value="XM_023579279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8H2"/>
    <dbReference type="STRING" id="1279085.S0E8H2"/>
    <dbReference type="GeneID" id="35399481"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06003"/>
    <dbReference type="HOGENOM" id="CLU_062645_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33810" checksum="35E5846699A7612C" modified="2013-09-18" version="1">MADTAEASGADHQQEPAKRNRVVDSVGEKAQEVFKEDYAQAREHVASAAKSRSYLYPIKGIFYFISHRSLWKPFISKLGPLVVLSTGVIGGMFFFTYLPQLAVLFFVNGPIAPLSAVLLVLNESTTIINLVSRNYLLQDALLDVFDGTLLARGDTQIVSEGREVKSGADPMQKLGKIIKSPFEKFSPKAIVRYVMYLPLNAIPVVGTVIFILIQGRTRGKGVHGRYFQLKKWSQPKREDWLTKNVGPYTAFGLVATLLEMIPVASMFFTFSNTVGAALWAADIEDKNASMIDGTAPTLRETARKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8T5</accession>
    <name>S0E8T5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_06148</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432276.1">
        <property type="nucleotide sequence ID" value="XM_023579440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8T5"/>
    <dbReference type="STRING" id="1279085.S0E8T5"/>
    <dbReference type="GeneID" id="35399625"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06148"/>
    <dbReference type="HOGENOM" id="CLU_025203_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="212"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="216"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="413"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="608"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT70197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="699" mass="78362" checksum="CD99A155B58CEAE7" modified="2013-09-18" version="1">MIAAALRQSPIIAVDMANSTTTTPLTTTSVSTGVNNGADTNTGATAPELSDLDYFITVLQLPHGRTENQIEDDLVSKANALGISSAPVTDKRITSSVESASTVYNARTFSMLSAGSTSTALTTHSSIFGPSTPDLALSSARQSKDLSFSQYDRYLSVIDPHHNNVKAARDSQTPDATAQSIFSGKTKRSLFSVRSGFRLRWRKKASPQPLQAILTCASCRADFKSSKSLHSISCGHTYCDNCLRSLIHTAMSDESSMPPRCCAQPLPGSLMRDLLSRDAQQEFMKAIIQYSTPWQARIFCSNPSCGGFIPPHQKLNPKYPSTVTCRKCNTRVCLMCKHNAHPTGKDCPEDWELDQVIKEGGKAGWKRCYKCQNLVPLEEASTHMTCRCKSQFCYTCGGVWDANTGCPNDCDGEEEMDRRRTEEQAQLAEYEDEKAAQEAAAAAASAERLEAEERTRNNADFSHLAEMHRQELRRFLEFAEQGREHMRTRFVEQKSSMMKRHAELKESMKEKHARTVSQLEDRQVAAEMDLRNTLEASERSVRIRLKHMEAYCDGLGRNGASSSPGSDSQPHRVVTERDLRELGQQYNIRDGMERSHQAKINVMRDRQAKRMEELIDRQEAEYETLLERNRQELIELDAQAVLEEETLVHTFTARKSKLVRRWELAIGILRKELEDQDGVKYAPIPTPTWPEQTSQVLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8Z0</accession>
    <name>S0E8Z0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433423.1">
        <property type="nucleotide sequence ID" value="XM_023580687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8Z0"/>
    <dbReference type="GeneID" id="35402070"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08594"/>
    <dbReference type="HOGENOM" id="CLU_473294_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="577" mass="61147" checksum="93B0C77C7844D207" modified="2013-09-18" version="1">MSDRGYQDSSKVSDAKALQLLFKSKTGAKSQSNIPKKRAGPSMQAARPAPARPSHVPPSGSTTPSTTDRFYTPTLLPNPLDRKAGAILGSSASDFLGRRDVTPKLSSNLVQGQDHKGKSEVPSTPSTVPKAQEVSPSPAQKESEKPVVKLPSTLAAIPEATKQDCNSIQEAEAHATSINPPTVSKTPERVNNLDLPCGFATDSGQTSIKASTAGTAAGHPKTPAQTINPSGKELKKKTLLELFQNQKSDDESDCGISDCQAKKAATHDSKTAEPLKYSPDKLLELKANAKTGVIPPDCIAKRHYNSQKAGIATTYKSAASFIAHSNTSGSGSQVGMTESTVPRPAAPQTSPQQAKIDSNQAPTVTTAQPAQVECLINFEEGQVELKPGAADKVPGTDSLHHQRWMSGHTYDDLVDLQTSSEHTKIDSIQAPTEAKSEYVQAEDPVACKEFRGPEEPHGLRPQAPGFVSRLHAPPAISMPDQYATPSPIDLGGSEASQHALTKTLVPADQFMVTAIPVATHANGFRITGPPTSQIMPRSPINDTFSTELPLRTAGDNEEVARAPRKPTKGLGASMWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9T5</accession>
    <name>S0E9T5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433750.1">
        <property type="nucleotide sequence ID" value="XM_023581087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9T5"/>
    <dbReference type="STRING" id="1279085.S0E9T5"/>
    <dbReference type="GeneID" id="35401711"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08235"/>
    <dbReference type="HOGENOM" id="CLU_029272_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485714" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="39"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="576" mass="63395" checksum="ED4616F774F8A225" modified="2013-09-18" version="1">MAWKVILPVFIFSLLASAAQVPREIQWTDDTFGPDGPWRGVNVQIGSSPTSISLYPGGTWETWLISDDYCERGTCYASKAGTYDKRTGDRTGLNILVELDNFMQGVNLQGDTSIRYRDDIMFGEINTINSTIALLDAQKIKYPGGQTVPFFAGCLSLGGPGSVNQSFEQPDGRPATNGSMPPGWFWENEYTPSNSYGMHIGSVKPSVAGSLWFGGYDKNRVIGEVLTLSGSPRGDGITLWDIAIEGVGDHSPFTSKSKNNLLAQGNSSITSGLKVTVDGCSPYLTLPKSTCDNIAEHLPVNFDSDLGLYIWDTKSDQYDKIVNSATALSFSFISDTNTDPVRIRVPFMHLNLTLSEPIVDTPIPYFPCHINNNGRYVLGRSFLQDAFIGANWHPDANSWWLAQAPGPKVQATTDVTSIDVKDKTISKGGNDWEASWKGVWDDEPAPPPSSTPTKAASPSEQDEVESKPSMPTATKVGISVGAGVALCLIALGLGIFFWRRRRRAQDQPSETQPALYKDNSDGFSVKWPSNLPPQEMHVPRHKLPPYEMSADERRIYEMYAHESQQKRPLTQRYELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA23</accession>
    <name>S0EA23_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_07050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431418.1">
        <property type="nucleotide sequence ID" value="XM_023577259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA23"/>
    <dbReference type="STRING" id="1279085.S0EA23"/>
    <dbReference type="GeneID" id="35400527"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07050"/>
    <dbReference type="HOGENOM" id="CLU_1396426_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22649" checksum="545EA61D933C2D71" modified="2013-09-18" version="1">MGLFNDIDIERDFPDHEVKSMVKRSEWAAQQHQDFLHHQYPTQEYSTIHSYSPTYYGNEQTSANTSYSTPRPQIYGLADLQAGLSLDGSGSEDDRSESRSEDEHAMGTKEVVCCGRSWKQGANFRKHYNRKHNRRLNCVFQNDCDYLGADKKELHRHYWVSHKEYARANQIPDPSGTCEACGKYFSRKDRTSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA90</accession>
    <name>S0EA90_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_08486</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433915.1">
        <property type="nucleotide sequence ID" value="XM_023580808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA90"/>
    <dbReference type="STRING" id="1279085.S0EA90"/>
    <dbReference type="GeneID" id="35401962"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08486"/>
    <dbReference type="HOGENOM" id="CLU_000288_44_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000163">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000128">
        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="238"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="538"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="743"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT71836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="807" mass="87772" checksum="F9AFF9DE1F7DAA1F" modified="2013-09-18" version="1">MNGDLSLSQALGGLRIANPDDAAEAVNSSSNSPPGPDSTAQNTSISASTSTSALPSTPQPTTTSTTPSSYDAIRLDPIDAGVETSLTDPRLTPSAQPSDPTSDPSPSVNHPQPSQIEPSRSSVYGISSAPEPGPNHSYPVRESSRRDPHRFNNSSRPVSGLMSGGSPLPPRRSSRGMGVGYASGPGGPQQNQPYAGDAPVPNSREDWQERGAAVGVRREVDANGRTVVRQVKKGVRDFSFGRVLGEGSYSTVYMATDRQTLKEYAVKVLEKRHIIKEKKIKYVNIEKNTLNRLTEHPGIVRLYYTFQDETSLYYVLDLCNGGELLGVLKKTGTFDIECTRFYGAQILDAIDYMHSRGVIHRDLKPENVLLDDQMHVKITDFGTAKLLRDPREDPSAASASGAPDPGKDDDSRAASFVGTAEYVSPELLTHKNACKASDLWAFGCIVYQLLAGRPPFKGGSEYLTFQKIVNLEYEFPPGFPPAARDLVERCLVLEPARRLTVEHIKNHEFFDGHPFGKGLWRTKAPRLRPYIPPPQEPQVIQLNGFSTSSNTRPPQQSQAIPSNGNNRPSRIITELPPPTQLDIEWSPVLTKNNERILKLGDLMVVSTPLPSSPHGKEPGEGHKKLSRFFIGSTTKKRQRLVMITSSGRIVLAPAGGEEKRAKQELSLLGSDCTWKTQVDAKGQMVWCVNTGGHHYTFEEAKSSSTPQEGGSAAADWVECLERARDMALSQNMTTSYGGDSGFADMSSQVSSPSSTLGGPGNYSDGFGLSDRQGRNHLSKNQGNSEDPAPKRNRFSKRQSRNGLGSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAB6</accession>
    <name>S0EAB6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431508.1">
        <property type="nucleotide sequence ID" value="XM_023578128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAB6"/>
    <dbReference type="STRING" id="1279085.S0EAB6"/>
    <dbReference type="GeneID" id="35401308"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07831"/>
    <dbReference type="HOGENOM" id="CLU_023951_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="592" mass="65364" checksum="3738E0918C654D7F" modified="2013-09-18" version="1">MTPRSFMLAQRQRESHHQRPPSPCTTGASHHNTLSIPTPSLSPAFTPIPTRLFSSSPSPLSSSVLLDTSSPHHQISIPINSVHYPYQPSPTYNTKLATSTAATSKSTTFSLPRWSPKYDDSNKNITATISSAQPNSNATMVKRKDWRETSSLAPSSPPKTTVSLTMRSTTPTSPVKIPTTNNRHGAHPQKRHSSQRKRSSDSRSSDKLSPSLVALLAVTDIPRHKQLQRRRRRSEKTLTVQEVIDCQHASEKELSWTFGSPLDMLLSPPQEVADDDDSVSDCNIGSGMSTRTYSIDSIPSLDESFSSECLSSLGSPRTPSPCSRRTNLTPMRKSLEPVISPPGSVDEHPLAGDDVDVDELDFSSLSQPEEAQPKSQFLEPFKPLRSVFKSNLTASLRALRSAARSFSVLNLPSIPPDDYLTRSILTIDPNVPYADERRPPVSEEMPSAAVRRYLNPTTNARIEPPTKTVFAGTFAASIQMRTYKIQRSRTAPGSTRNSYPSTSLQSQPAPVPQQPQPQVPTQSVPGMRQREMRENSDFIRIAVMEMAMRKRGKLDDQRPGRARFALPPRQTSTKPYEMGANGVPARWIPITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAD5</accession>
    <name>S0EAD5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">FFUJ_08333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAD5"/>
    <dbReference type="STRING" id="1279085.S0EAD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08333"/>
    <dbReference type="HOGENOM" id="CLU_022833_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT71580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="426" mass="47013" checksum="17A226CA61DA1932" modified="2013-09-18" version="1">MASPVSHRRLVASIVYRTLYLLLYVCLLGLLISTPADAIHRSFQNRQLYNIWIVAAAYVLAIVIISFVFITRLYINKTDLGSIPKGWVPIEKGDLRSAVYKVIALGLGRSASIAYESRPRLQTDNTAPDDETVETRVKLGFDGPSGPAEELVVVIPRKKPVWGDIEHYGWSSPNAPDLPNLEYTTVFSELPNLIEGKALTLAPPDPTSDTNPPLLDPDAVALLQRTANMSLRDYVVHLAELGVIEMDSTTIEFLSHYEYARFSNRPISNAQFKELMHLFAEILHAMEPLDPDVLDEQDDASSPSTDGDDDTRPRLGTSRSNLAPSDASISSSARIRRQPSTNTWNVYETAPNSVRSGFTGPGSISRRLSNNSLARSRRHYPLSQPSTSSLRSKSSASSGSVIRLATRHDSTDLPYVLSLRDTTASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB81</accession>
    <name>S0EB81_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433993.1">
        <property type="nucleotide sequence ID" value="XM_023581252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB81"/>
    <dbReference type="STRING" id="1279085.S0EB81"/>
    <dbReference type="GeneID" id="35401564"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08087"/>
    <dbReference type="HOGENOM" id="CLU_532738_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="533" mass="58004" checksum="8AA4953A838295E2" modified="2013-09-18" version="1">MPWNVTVDSSSKRIGICFYFIIADILLSTVDAVFDAVEWVFNAIKTVIQDLIRFLELLLDWEDIKRTKNVICSIAKLFMQGQINLIASAKPFFDQEMNAPVTMINGWAGDTSWTGTIGQATTHPLSVSGQNSSTGQTSGSQMLSNHYKNNASSLTLVETDTAESGVEELVDNLLTALENENKTMIAAYNNLKNIAHNISSQPLQDSLKQLVTIIADVLISILGNFGDAILDILTTLASSAMHLLDTDDLDISEPSILDLFHWIVAVAYTVIYKISNNSAPFSDNDDVSALINSDSWHTLQSILGQPPPQDELSYYSRVASYIWSAPKEIGDSTKKSIYRCLHTIGTDIDLLNVFVVPLEADGSSDSKQNAFSGPMSVLGYLNTACHVVAGFAVPQNPISNEVLKAMHYRNIAVKVLASPILKKCMKVNRDNRGFPALDKRGMGALVKVVVGYWGLFVTAGHLYELSHDAPSSNRTAAILTEVGSILGEISNVAYCEAVNDPDRTTREVPLLVIAEVGLIEAGLEVSLVATVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBN1</accession>
    <name>S0EBN1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_12216</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434434.1">
        <property type="nucleotide sequence ID" value="XM_023581796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBN1"/>
    <dbReference type="STRING" id="1279085.S0EBN1"/>
    <dbReference type="GeneID" id="35405672"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12216"/>
    <dbReference type="HOGENOM" id="CLU_013808_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000512">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="558"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="546"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT72356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="644" mass="69867" checksum="A7F2714AAA8B8DD6" modified="2013-09-18" version="1">MPQDPAAALSALLRQSSVEDHDEALKIANAALKANKNDVDSQHTRIIALLKLDRFDDALRAIADGSPALHARIALEHAYALYKTGKLQEATSVLQAFGLEKKRSLQHVAAQVAYRAERFDEACNIYSRLLDTHPADEENDISINLRAAFAQSSWLGYSVTDKISVQDSDGFELCYNAACAHIANGSLETAADLLQRASRLCDASDDLTDEDKQAEMRPILAQQAYVFAKLGKLKEALDLYNSLSSAKEEDPDLALIIGNNLVTLEPKDENPYLLERRFSTLTAEARNAKLFQHQSDILRRNRLTVDLQILKGAGVKRRTDALLAEAKHPLTAAETSILSVLNAAASAQGTSGKQLLNNLQGLTQKRPHDVGLVLTIVQIQLNEGKVGSALSILESFLQRLEKNETDDSQNARFSSGLVALTVTLLRTQGRESSAKAELVKAATYWQSRPASSAVSLLEEAGIELMKSSNAQDLQLAGTSFQKLIDERKGSDIAAAGLVASLAPSNPSRVEKHLQNLPPVDSLVEGIDVTALLSAGVATAASKTGFSTLKRSAPSGPSEKTSKRRRKIRLPKNYVEGTKPDPERWLPLRDRSSYRPKGKKGKKKAVDSTQGGIVKEEETLELVGGGGVKVEKAPPPSKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBP5</accession>
    <name>S0EBP5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431923.1">
        <property type="nucleotide sequence ID" value="XM_023579011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBP5"/>
    <dbReference type="GeneID" id="35399241"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05762"/>
    <dbReference type="HOGENOM" id="CLU_1102850_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="252" mass="29023" checksum="87453D175E5A6360" modified="2013-09-18" version="1">MDNDNTMKGFTSSRSPSSSGHPSSTTLEEKKEAHHPVAKGEYQQEVLKVAQRTYPKELPPAKNTMLIHHIRVSGAYVDARDEFAAISQPTDLGWSEVHCLYKYLLAFELSHPDTMTRGHLTQYGDLHYFLTAVFFNWETGKEIKPQPVLPERAFDDYAKDVGLLIRDLDPIVNKDGSLDASGRCMWDQAYLAFKVNQKTLEWQVSWVDCNGNSLKREDVQLYDKYKNNYKEAFDATIENFDRKQNQRIMAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECH2</accession>
    <name>S0ECH2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433596.1">
        <property type="nucleotide sequence ID" value="XM_023580903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECH2"/>
    <dbReference type="STRING" id="1279085.S0ECH2"/>
    <dbReference type="GeneID" id="35401877"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08401"/>
    <dbReference type="HOGENOM" id="CLU_022034_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="618" mass="65713" checksum="5DD6A24288CBD360" modified="2013-09-18" version="1">MASSNPFRKSAAITVDSTSFLNSTSSAAARFPALDQIETASTPPPPTSFQQVGSSTIDSKSKITKKVRVLSPPPLSPDSPEWAFAAPSIAQQAANQQNEDDPFDATSTDDSDREMVAAAVHNYAPNDGQGIGNPFSKTLRSVDSPVAEQKLEHERKEEGQALKAANTARRSLDVNSFKRLLMTGNTESDKSSPPKIRQSMPPPAKNTKDRPSVFRRISHDDSKDISAPENALQEASLISEEASDTPEDDIDQENVSDSSTSAQLSTKNSKRPPPPPSSRHGKSIKLDLVGQASREPLATLSSDMNKPLPPAPVRRSMEEGGDSPFDREAAGKVPDAEGDMGSASPEPSGGSRKAVPAPPPRRGHARGESKAYTAGLGLTQQQFVHNEENLSRSSSMRSRPEHNRRDSHAAAPPPPPPPPRSHHTSRQSTQIPLGVASSLTDLSQSSSSPAPSLDVDMSNTSTPSQLRQSSTVELTPPRDTQSGTHQPVTTTKSWAPPPPPARNTSVRRPASIRSVDSSSRRISFEAKPHNQMAPPPPPRRQRGSSRGSVDGPRRTSLDGVGKAVSSQVAEEEPDNVAATVGSGPTSPQSANEPGKSVDILADLDALQREVDALRGKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED75</accession>
    <name>S0ED75_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable metalloprotease MEP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_12733</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434917.1">
        <property type="nucleotide sequence ID" value="XM_023582374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED75"/>
    <dbReference type="STRING" id="1279085.S0ED75"/>
    <dbReference type="MEROPS" id="M43.008"/>
    <dbReference type="GeneID" id="35406189"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12733"/>
    <dbReference type="HOGENOM" id="CLU_048726_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485127" evidence="10">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="11">
        <location>
            <begin position="128"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT72839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="275" mass="29794" checksum="831AFA2C967A1A7F" modified="2013-09-18" version="1">MVSKLALALFFGNALAGLAGRAIPPRCAIADPTPEQVQHAQNLKKIESVSKVAATSIIVDTYFHVVSSSSSKYITKAKLQAQLKALNDAYGPHDVTFNLIDTTFTTNSNWAAGNGEVAMKRQLRQGDYKTLNLYFTDVAKLDGLDALGYCFFPEPNVSTGSSTFIRDGCVIVAETVPGGSMAPYNLGGTAVHEVGHWFNLFHTFQDGCTGGDLVSDTPAQASQTSGCPARRDSCPNQAGDDPIHNFMDYSDDVCYEEFTPGQKTRMHSAWTTYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDM4</accession>
    <name>S0EDM4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_12914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435094.1">
        <property type="nucleotide sequence ID" value="XM_023567768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDM4"/>
    <dbReference type="GeneID" id="35406370"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12914"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="193"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT73016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="427" mass="44706" checksum="E791BECA72659F2A" modified="2013-09-18" version="1">MELEPISIRDPIIVEVETPTEDPDTPPDGGYGWVIIFVCFVHTFWINLWAGSWGILQAALLRTTLKGSSLSAVSFVGSLGVALGPALGIPAIRIVRVIGARAGMTIGIAIYGLGCLASSWAVGSLVGLFFACGVSYGIGSAFTDTLYNTLPVLWFKKRLGLANGIVKLGGSFGALVGAVSVGYLTEGVGVAWTFRILGIASLVTGIPTALLVKDRGAPPEYPVKWSVFRDACFSWHFAAGAVGIFPIYAPTFFLPYINNALGFSNSTSIATLACLLVCMSVGRILTGYACDRVGSMNALFFASLVNAVSLFAVWPFSSNLGLVLLFCILNGLSNGGFAVAIPTAVGRHLPIDDAPGALSLLFTGWAPGIMGGNAISAALIQVTHADVADSIVPFRPAMYYFGGTALLSTACGVVARLIYSRDMRVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEB3</accession>
    <name>S0EEB3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435073.1">
        <property type="nucleotide sequence ID" value="XM_023582552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEB3"/>
    <dbReference type="STRING" id="1279085.S0EEB3"/>
    <dbReference type="GeneID" id="35406349"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12893"/>
    <dbReference type="HOGENOM" id="CLU_047146_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="474" mass="56736" checksum="FE66EB756A2B08B2" modified="2013-09-18" version="1">MDPNLEFYRSILHLGPRERRERMQHLPESECDRVRIIIEREEDTRRREEAIAGRDLVQMALESISEITENHYLESALLGRTTYYDDECMMIRRITNRIADSSSTLVHRIALFDQHMDPFCLDAWKLVYCDVCYVDGSSATLQEIYESRLREEELQTPAEQARELVRDKDLKIGRRNAKWMIPAIERLSAEERDEPDQEERELRDKLLQQGKYDELVERLEKQRIYTEALQRLWKQVSPSPPAWIQKVLETGEEFGFVYYRSREVYQSRYNWNSVWSRIRNTCSPLRVTWASIHCQGRDNWMKLSSLSVEHWPVFSPDESMTEDEDLRKHFKKYCQENRSKTEEDEKKKKKRKRKGTEDNETVLSPGILRNTFIVIPIEFVSGNLNIEEGDFYDPCWVWAYDADWDGSEEETVVDGETYQGRVKVAKWSLNSWFYAARWEGVSLRDMWLKAQQHPDKYWICYTKELEEWDHEPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEX6</accession>
    <name>S0EEX6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435589.1">
        <property type="nucleotide sequence ID" value="XM_023568382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEX6"/>
    <dbReference type="STRING" id="1279085.S0EEX6"/>
    <dbReference type="GeneID" id="35403155"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09687"/>
    <dbReference type="HOGENOM" id="CLU_050091_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485552" evidence="2">
        <location>
            <begin position="22"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT73511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="324" mass="34367" checksum="778ED0AEBB812658" modified="2013-09-18" version="1">MASALSTRLAAAALFALSVTAQSSPAMSIESFIRAADDVLHRPYVSLLSTPLAERDGNATVEQLPAGDVPLTKDGSLNMTAWNMDTNAACRSVLGGLHKSTNPSGTCVCYNLPSLDVKTGVFEADVRLYQVSQPRGSFAAVAPEDINVGISYKGASVMPIQPADVNGTGLTGGKPGMGKRQEGMQLLQSYMLVGKIDADKMTDNMTMDELECHIMPTLTLTARNSTGSTIRTNVSINEAAFLTGVFSQDVVMSDFAMASAAVDDQVAALNNGTVAFVLPGVQLMVLPIGLIMMSAVGFGTYERYNYALMYKRRQAVTMPKKATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGP7</accession>
    <name>S0EGP7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_09346</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435908.1">
        <property type="nucleotide sequence ID" value="XM_023568762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGP7"/>
    <dbReference type="STRING" id="1279085.S0EGP7"/>
    <dbReference type="GeneID" id="35402815"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09346"/>
    <dbReference type="HOGENOM" id="CLU_044863_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012633079" description="Pectate lyase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT73830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="306" mass="33903" checksum="2938A77924B29E41" modified="2013-09-18" version="1">MKASLLLSLLPVAQAAVIDTRQSKTGDGKQGDTDATQGDLSQRPPPRFPFPITKFPVAKETVVFKNAKYIMPGEVFDGKMKRYERPEGSCNEQAEGTDADTVFNLLPGSTIRNVIIGKNQAEGIHALGDAWVENVWWEDVCEDALTSKGLNTQLRVIGGGARSATDKIFQDNSLGGKYNITGFYAEGFGTFYQSCGNCLNQAKRNATIQNVIAVDGLRMGIINPNYGDEFRLKNAQIDNVTSIVDKEIGNNVQTVPYYIGNGPDEKYALYNETRDNIVKFKGKVTNAYEPEDPYEWLEEFWPEGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH70</accession>
    <name>S0EH70_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to HOL1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435265.1">
        <property type="nucleotide sequence ID" value="XM_023567885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH70"/>
    <dbReference type="STRING" id="1279085.S0EH70"/>
    <dbReference type="GeneID" id="35403602"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10136"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF164">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="546" mass="60349" checksum="09D01E5715F9311D" modified="2013-09-18" version="1">MAERRDSFGMKPDVDAVEDIVKTPHHESHDASGTVNLYQDGTVVLVPTPSPDPKDPLNLPIWRKYMIILLVGFYSGISVLGTSGLGSVAPELYALYHNDNAKRVSDLLTYPTLFMGIGNLLSMPLANAIGRRPVFLFSLLLLTVSGIWCACSKSLTSHIAGRNIFSLAAGQSEALAPLIVQEIHFLHQHGVKLSYFVGVQNTLTAALFTATTYIVPSLGLPWWYGIMTIINGFTMIMSIFFLAETRYDRPEDATEGAVHLKLDKNGNVAREGTNEVLYQVTTRNGVVLQPEKFGERTWRDDIKLFHGKADWKSLVSFYKDVGLSLILPPIFWIFILNGAFLGLYIYQASTFAVILVQPPYNFNGKLLGYVQLVQIIDCLLAVPLLGFGSDIICKFMSRRNKGVFEPEYRLIVLIIPAACAIISAIVYGHAAASPNDYHWIAIVAPYHLGFFSFLGANLVGITFVMDSYPNKSGPLLLVVCAGRGFVSFGLSYATVPSIQSLGYDGAMNILAIICGVLSALGIVMYFIGKRVREWARRRIWPKHHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHW2</accession>
    <name>S0EHW2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_09769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435515.1">
        <property type="nucleotide sequence ID" value="XM_023568292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHW2"/>
    <dbReference type="STRING" id="1279085.S0EHW2"/>
    <dbReference type="GeneID" id="35403236"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09769"/>
    <dbReference type="HOGENOM" id="CLU_019188_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="9">
        <location>
            <begin position="228"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="643" mass="70883" checksum="A7A7018988D90AF4" modified="2013-09-18" version="1">MAIPVGRTLFKKKEGILTLTSDHQLVTWTPNSGGPATVSLNINNITNLQQTPDSSPKVMLKIFERVGDAEPATYLFHFNTAEAKDEAKAVKDLLSSLLASTRGNDASVQKPSGASGGSSTPNPGTGSGSASMAFASAVNSQNASSSRWFDDSQLKNDIELQQSLMRKDTSLHQTYVEAMQTKPDSLSGAAFNSQFWSTRTNLLRAHAIEINQKKGAYNVLSTVKPKTVDGELKLNISVEQVQMIFAQHPLIKRVYNENVPKISEADFWSRFFLSRLSKKLRGERVAENDPNDPLFDKYDPAENTVAFQSKIMANQVPHFIDIEANEENQGGFKSGNAKDVEMRPRANIPIVKTLNSLSEKIMANVAPSDVNTDDPDGGYNTYVQLALRDLKGDAKEHRIMLNVKEQNKFFSKHDSAPSKQAAVFERQVPSEVLFEIVGDLETLESDGAGGINIQAAMGFDEESESDEDIPKRPHVGSRFALLAADKDIMKGVRQQRAQKYGHETDAAEPMGLPVEVSRKCSLTHATTIEFLHQFWNAFLSGDPDRAGELQYLAESLGRSLARINAVAEEADKEREEIIRNRKKEIRDHFQRTGKKIRWRSDNVGGGKAAVIALMQPTMNALEKAQADYSRALAAEGIQISTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIF3</accession>
    <name>S0EIF3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chorismate mutase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436503.1">
        <property type="nucleotide sequence ID" value="XM_023569264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIF3"/>
    <dbReference type="GeneID" id="35403940"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10475"/>
    <dbReference type="HOGENOM" id="CLU_1555339_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496003" description="Chorismate mutase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="186" mass="19716" checksum="49B2BD8A6D70F0E2" modified="2013-09-18" version="1">MHLTSPLYTILLLCTAAAAGSCHLSSAKIARCIEKPSINATAHNYPGSPLSAHSTTYPYNVTCLNDVPVAASACRSTDPDEALACARKFIDAIDEQISFLYARRLGYAAVAGAAKFNNGTALNDPTRNQAVAAGMAARVLKYGGSEETGRIMGGEGCQIYASLEYEAQQIQNCGGKLNETFERVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIT7</accession>
    <name>S0EIT7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to arylamine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434371.1">
        <property type="nucleotide sequence ID" value="XM_023581716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIT7"/>
    <dbReference type="STRING" id="1279085.S0EIT7"/>
    <dbReference type="GeneID" id="35405601"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12145"/>
    <dbReference type="HOGENOM" id="CLU_049918_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="320" mass="36655" checksum="1A1CDDA1EA766B9F" modified="2013-09-18" version="1">MASAYSQEQLSQFFDYIDLPKGLRGDLRPSLMLLKALHTHSLATFPYENLSLHYNATHSIDVDPQHLFRKMVIDRRGRGGFCMEIAILYNHILRAIGFDAYTAGVRTRGRLEGVPRGDYPGWNHIVNIITFPDGSKYHSDVAFGGDGATMPMSLVDGLVHKNLGTQQIRLKRDWIPHQVHKTEETKLWIYQYRNGQDKEWTSFYSFPGIEFFALDWDVVNWWINTHPDSHQPRNVLTIKFLLRPVEIEASFEGEMEIYGKRMLVNGVVKENLGGKTQIITTCNSEGERVEALEKYFQISLSDEEKGGIRGYVSELRGTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK40</accession>
    <name>S0EK40_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to quinate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_12650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434836.1">
        <property type="nucleotide sequence ID" value="XM_023582281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK40"/>
    <dbReference type="GeneID" id="35406106"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12650"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT72758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="541" mass="59644" checksum="BC8F3D82C5971D52" modified="2013-09-18" version="1">MKFTLGNRAAMADTPSEVMNWRLYWSTFVFGVLGASRGLDEGLVGGMVTLKSFKDEFGLDHGSEEHQAQVESNITSMVQIGSIAGSLLAFFLCDKIGRVRSLQFLCMLWLVGFIIVVTSHGSVGQVLAGRFIAGLGIGMTVVVGPTYLAETAPRAVRGMLTNIFAGSVYLGVMVAYFSNWGASINMPDSSRYQWVAPQTCHIGFSGLLLILSFTVPETPRWLTMKGRNEESTKALCKLRQLPEDHPFVQAELYGIREQLEREQEAILGVSRWGKIRELLTIPANRYRLMLGFMAQLLGQWSGASAITIYAAEFFGVLGKTGQSEKLFATCILGVVKLVSAYACALFLVDFIGRRRSLYAGITLQTISILYIAIFLTIVGTKTLEDGTLTSTQKHAGVGAIAMLYISGVGWTMGWNSFQYLVNAEIWPLRLRALGSSITMCLHFANQYGNTKAVPLMLLHMTSGGFFFFCAAVCILGLIWVWAFVPEMAGRSLESTDELFSLPWYKIGRYGNKLAPDNEAILARDEKAEMKREVEVSQLEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKG7</accession>
    <name>S0EKG7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to large-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437377.1">
        <property type="nucleotide sequence ID" value="XM_023570237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKG7"/>
    <dbReference type="STRING" id="1279085.S0EKG7"/>
    <dbReference type="GeneID" id="35404811"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11349"/>
    <dbReference type="HOGENOM" id="CLU_010103_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="624"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="755" mass="83464" checksum="07F876CDED8B3334" modified="2013-09-18" version="1">MAAPPAYQAVDDTPAPGPDDLTAPFTDLQIDYLPHEPDSSTCLAHLRLLFAFEALKEDIGYTDGLWGLWDTRADGNMVVHENGDVDEHPAAGEFNHELEDKKKSLSKVREKRWALFVARAVDRYEAWWDSLPRELSRLTEGIMTDKNSPSFAQFPVGDAPRWWEKKALPPLDVLMVYHSHMLNPYNFLEDCIRQGHRQFWQSGMPWGLVNAAIDGSFSYNVSDDDKARWVAQTGRQWDNVDDPLVKTISCPNKNCAQPFDVPWTTCGLEETPKSPDRPGLMGAGYGDIRFEARCPKCNTRVTKETLSVVKFCKDAENVVFKSYPMPGTILWPNSGTPVPITTRKGNVFDQRMFPNRMIQHVLRLQIQNLLDSPDPEDPPTMETVRKLIESEALLKPSALAIINGSVASGRSGLVPAFSKVCIRKMMSRYWENFSPFALDLCGAVMRQGIFAEKMCKLDWLHSPTARETMDRCCLKYNRFMRIIAKNPKKTAVPTLDVDLGWHTHQLMPLSYFMYTTKRVFKYVRHDDKIEDEKLNDGFEWTSKIYQEMFDEVYSECTCWYCESVRAAHVTSIGRVLKLSHSEKIADKFYESGAADLCPPDNSAHISSHNAVRTSNEGLVAASHVEKVQNRLREVQNKRLEENYQKACKRAEKKGRKLPPKDQYYDHWGYSYWMYGPFMAPVVFVPVAYGYGAAPGCAAGSCGGNAAGGGCAGSGDGGGCAGAACSGGGCGGGGGGCGGGGGCGGGGGGCDGGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKL0</accession>
    <name>S0EKL0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437579.1">
        <property type="nucleotide sequence ID" value="XM_023570471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKL0"/>
    <dbReference type="GeneID" id="35405021"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11559"/>
    <dbReference type="HOGENOM" id="CLU_040944_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="494" mass="57003" checksum="C3EBAE3D33C9410B" modified="2013-09-18" version="1">MRVSNMRLPNSLRNLSVRLSSIRIPHPHPRRIILYVTTTALLVVMILTFTMSDRLFGNGRSGYDPLLSRTNDYRLLTSTRNNLGFYNSINVKKTGQKIMNPTLLELPKGSKHDFLVIARAPHVDQDIKGKKYRRAQQVATFVSLTWDAFGRPELTADNDWHKMLVEDFTEAQGPEHHCKNQPDMDKYIGPEDMKLFWRKNGTPMLIFTHQVDDENLCEGMYIVDARAAVPELVKQMGKHAKELPAIEFDKPVLLRRQPPEGQESDARYQREKNWAPVYNPFSADDDEMMFMVEPSQLFRFNSTDEPVQNMEAEPESAVDEPFPPDNEKKTWHSAEKNCMNDVMLTDKRVHQSTPMLSLTLCNRGTCEPMENNTVIMGMVQMRYDPPQYTNTWYDHRIVVYSPVAPYHMMSVSKKLTYHGETNSRYIWTGSMVYHGDQPTQRSHGYLDDEIWLSFGIGDSSPGWLDIKAEELVLDHYFCQGATPGYRSSIKKHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELQ8</accession>
    <name>S0ELQ8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to hydrolases or acyltransferases (Alpha/beta hydrolase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438019.1">
        <property type="nucleotide sequence ID" value="XM_023570992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELQ8"/>
    <dbReference type="STRING" id="1279085.S0ELQ8"/>
    <dbReference type="GeneID" id="35405487"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12027"/>
    <dbReference type="HOGENOM" id="CLU_020336_13_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF8">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="308" mass="34467" checksum="1F38FEA7D2B33165" modified="2013-09-18" version="1">MTSSQNDPTALTQSFHYKTSTHSYDVKWDSLGDPKSPPLIFIHGTPWSSRVWVPFALSLSRQFHVYLFDRPGFGDTPAEKKLDPTKASSNAIEEYDSNLARQAEVFAALFKSWQADWTHEKAHIVAHDNAGLVSLRAYLLHDLPYASLCLIDVVAIGPFGQPLFKVIAENPQLFEQLPGTAFEGILESYISDAAYYELPKETTQMLKEPWLREGGKRGFIRELCQANSRSTEEVEARYGEVGPKLPIKIIWGADDKWLPVEVAHRLGDALKAREVIVIDKAGHLSIIDQGARVGVELGLWLSTALHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM49</accession>
    <name>S0EM49_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437050.1">
        <property type="nucleotide sequence ID" value="XM_023569899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM49"/>
    <dbReference type="GeneID" id="35404510"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11046"/>
    <dbReference type="HOGENOM" id="CLU_396367_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="267"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="711" mass="78822" checksum="DE063F1D6071C6CA" modified="2013-09-18" version="1">MPDPAPQIVVGCLLDVSGSMRSALEPGQSNEPAGDRLRAVLRAALKLAKAERQQNSSAFMFVGVFGLRTSEKYPNPQAADLCGIADALLIDSENSSSGHDLLIARANANNVSYISRHIKTKLSSQEARIVDAHLKLHPDQVQQFIDAIPPEEEVTRLRSSSRQHSAGAGITLGCAVSVVVPGAIVAAAAVSLATIMAGEMASNSIEDSRVERSEALAFARRIQRDWLSDFETFRPRPIFEVVDILQRLQDQWLDHEDSDSRNVSEEDNDNLFDAIRQYMYGLTPMCYALQKARDAFRSNPEAKRRVLVLMSDGISTDGDPSTAANDLRMEEVSIATVKLTDDLSGPQRALYYEANPLWDVGTRDLFSMSKRIDALTHPVPVLAAAGWAIPLAGEVALFCTVCTVRALEEFCTLLLSARFGSADALLDIVGSIRHDDYINNEHLAIQRRPTHQGKRRICYAHAVASVIHMALLRIVSREGGVPSFIEIRERILSEYPETEAGQPTEDVLSDACIWYRPLQFREVDEKGAREAVLRRRPVLATFGLSKKGWDEFGDHFDENSATRTAVLTEAQMAPHFNKKFDGGHAVVLVSCSPGSLAFLNSWGSAWGDNGIFKIENPVVLGHKDRCLRFYDVYWVEEKLTDAERQAFNARVDEELRRRAEEHESIFELEYRCPKCLGNSALADFRGSVRRALCPKCQACFEPDPGHLAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMJ1</accession>
    <name>S0EMJ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438072.1">
        <property type="nucleotide sequence ID" value="XM_023571060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMJ1"/>
    <dbReference type="GeneID" id="35405548"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12088"/>
    <dbReference type="HOGENOM" id="CLU_1019601_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496164" evidence="2">
        <location>
            <begin position="23"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT76026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="273" mass="28584" checksum="1CFDF62AA2C751C8" modified="2013-09-18" version="1">MSSPKLLATLLAIFLSFTSISAGPCKPQSSLSESTTTTLGAETAFGLSSSTASLPTSFTKSVVSSVEVADSTTTYPTTDIRNLGTTTADGTTAAGLPVTTTDATNIPTTTTEATGTCTLGPMLDPQPNYHLEFTIGVETCYHLDRSYRWRLGGGASNGFNPWVLTTDGGEFFSVQNNGHVSYRRGYVIAQEPGTDNIGGISDSDTARASWTRLTCKAFTTSNAPFVYMTCVGDGPENSIFQICQLSPNGPLSLLLSSSVSPGCTEARLFAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN37</accession>
    <name>S0EN37_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to SUR1-required for mannosylation of sphingolipids</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437405.1">
        <property type="nucleotide sequence ID" value="XM_023570269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN37"/>
    <dbReference type="STRING" id="1279085.S0EN37"/>
    <dbReference type="GeneID" id="35404840"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11378"/>
    <dbReference type="HOGENOM" id="CLU_036369_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="360" mass="41389" checksum="4E7382B822317735" modified="2013-09-18" version="1">MSSSPILGPERKNSYDEERLEWATPSVPKKYLRLPRLRRSTVILLLIDFLIVAVLVHAFYPLITLLRRNEELFGARLTLPLNDTSFGEDVPAQRTIPRIFHQTSANETIPEAWKDLVKSCRDTYSEFEYKHWTDAKARDFISEEYPWFLDTWDTFPFNIQRADAIRYFVLHHYGGIYLDMDTLCNATIPLHQIESDGTKHHAVFKSTTPTGVSNDMMITSAHHPAFTKALSRIQLYNDITRPWAHILPHVAVMVSAGPLFLTMALKNYLLEQPSLPETTIQVINATELEPYLTDYEGASWHHGDTKAIMWLGDHSWVWYVLTVVGVVGGLYLINMLLMKCWARFFEKASSDEAKDAIKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENG7</accession>
    <name>S0ENG7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436151.1">
        <property type="nucleotide sequence ID" value="XM_023568248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENG7"/>
    <dbReference type="STRING" id="1279085.S0ENG7"/>
    <dbReference type="GeneID" id="35403276"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09809"/>
    <dbReference type="HOGENOM" id="CLU_006383_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="6">
        <location>
            <begin position="11"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="442" mass="50748" checksum="AB44313A5B9BD3C1" modified="2013-09-18" version="1">MPSRTNGVGVQAEDTRICVVMVGLPARGKSYIAQRAQRYLQWLSIPAQTFNVGNYRRNDAPQPTADFFDINNPEGERTRRAAAEAAVADMLAWFRSGGIVGILDATNSTLERRKWVLEVCNENGIEVLFVESKCDDEELIMANIRDVKTTSPDYRGQDPETAALDFRNRIRNYEKVYCTIDADGKESHLTYLKIMDVGKQVIISRIRDYLQSRIVYYLMNLHIRPRSVWLSRHGESLYNIDGRIGGDTLLSPRGEQYARKLPELVRKSVGDDRPLTVWTSTLRRTIATSRFLPQHYNQLQWKALDELDSGVCDGLTYQEIKDRYPEDFAARDEDKYNYRYRGGESYRDVVIRLEPIIMELERSEDILIVTHQAVLRCIYAYFMKKDQSKSPWMNVPLHTLIKLTPGAYGTEEVRYEANIPAVSTWRGKGSTAKHENPAPDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENL3</accession>
    <name>S0ENL3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437710.1">
        <property type="nucleotide sequence ID" value="XM_023570625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENL3"/>
    <dbReference type="STRING" id="1279085.S0ENL3"/>
    <dbReference type="GeneID" id="35405158"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11697"/>
    <dbReference type="HOGENOM" id="CLU_122470_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="175" mass="19905" checksum="74E8AD46D3554A89" modified="2013-09-18" version="1">MTEQADENDNKITECTFPPGSRRVEYEDLDPAQKELEDILATMKHDPTGMGISHLGRDGIHRSLTADRDVVDAVPFPPPLIKAMLDRLPYSEEAVKVFRGVDGTKTPKEQWYKPLPGTLPPPLEEKHREEAKNGQEDYRKWYGERMKKVEAGIFERRAVCLMSDHDLGPEAMSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENU2</accession>
    <name>S0ENU2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436446.1">
        <property type="nucleotide sequence ID" value="XM_023569198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENU2"/>
    <dbReference type="STRING" id="1279085.S0ENU2"/>
    <dbReference type="GeneID" id="35403880"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10415"/>
    <dbReference type="HOGENOM" id="CLU_624107_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="514" mass="58902" checksum="E7E74C5460F020D3" modified="2013-09-18" version="1">MGGESERHSGDDDSGGALKNIGDQLRPKSEDEGPYEEVFNFGTHSDPLTKLQQPRYSKTEDKKPRYYPPADATMTDVFETVKASEHQPKQNPGVIGRITQSLNPFGASEPSAVPERVNEKKPSHKSETSREKKLQKEVTQLRTEKISLSTSLNNLTIKFNLQSNDLDGKKRRIKQWEDWKTESDEHWRKRGEELRKAQGAYDRLFDDYKKLKKTKKDLETELDEERDVNKTLRQDIQNQEVVVTEAHSRAISLLAGHVSSDFPDDQVRTELQVLFEKCSEWCIDNRLPLIESVEETRNLMLTQGIMNDPDCEEHLRFDVTHRTATAVLLQAALTKTLMQTFLENPFFLGQHYLNKTALQGGFAEATVTWRIQTCQYLEQAFPPHNQAMQAYAEGFARTYEPLIEPLDRESLTQLTNLFATTCSLALRLWKLRTNIRVEELGDATLHRFQSMFGDMEAHPTVGLLKGDKRFDNRPICVVVRPRIVSEPVESENRGRGIVWSLAQVWVSNWEDAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENW9</accession>
    <name>S0ENW9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436511.1">
        <property type="nucleotide sequence ID" value="XM_023569273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENW9"/>
    <dbReference type="STRING" id="1279085.S0ENW9"/>
    <dbReference type="GeneID" id="35403949"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10485"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="249" mass="27108" checksum="F3C528445820F138" modified="2013-09-18" version="1">MAGLNAVLLITGAWHVPEHYYKLIHELQSRGIRVICKRLPTNNNVVPPNKTIQDDIDFIKGIVSKEVAEGTHLTVIGHSWGGMLASAALANFAVSPGSKEGGVTDMIFIAAFIPSENDSLAGLSGGKPPPALVAESDGTLVPTVPIHLFYHDLPEEEAQWAKSTMVAHGTDVQYAPIDCQKVAWRVIPLAFFICEEDQGLLIFLQEGMIAKVEDQGVTVQKYRLPSSHSPFLSMPKKLADIVLVFMNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP39</accession>
    <name>S0EP39_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to maackiain detoxification protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436711.1">
        <property type="nucleotide sequence ID" value="XM_023569503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP39"/>
    <dbReference type="STRING" id="1279085.S0EP39"/>
    <dbReference type="GeneID" id="35404155"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10691"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000331">
        <property type="entry name" value="FAD/NAD(P)-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF187">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="124"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="438" mass="49098" checksum="7779FB6AD26C0946" modified="2013-09-18" version="1">MAAHKSGVKVIIVGAGFGGLTAAIECHRQGHDVEIYESFPELKVLGDIISFGGNAGRIFNRWSEGQIVARLRPLCIDIQEYGFRIHKWDTGEVLYHQKRPPPNPEAPVLNGHRGELHEIIFSYARDELGIPIHLGQRVSQYFEDSTQAGIILKTGEKITGDVVIGADGVRSKARELVLGYVDKPKSSGYAVWRAWFSNKDMIQDPRTKEFCENGDTFNGWIGQDVHFLFSTLKGGKDCCWVLTHKDDHDIDESWSFPGKIEEVLELLKDWDPTCRAIVEKTPSVVDWKLVYRDPLPTWISNKGRIALLGDAAHPFLPTSAQGATQAMEDGVTIAVCLKRGGKGNIPGALKAHQSLRYERVKAVQKTGESTRDLWHKTDWDKVKEDPSSIGFPREDWIHQFDAERYAEENFESALKTSWHEVKDKVQVDEAPAMAQVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP67</accession>
    <name>S0EP67_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436781.1">
        <property type="nucleotide sequence ID" value="XM_023569587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP67"/>
    <dbReference type="GeneID" id="35404230"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10766"/>
    <dbReference type="HOGENOM" id="CLU_2263933_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="95" mass="10902" checksum="E7D1004AA999A056" modified="2013-09-18" version="1">MSNNHNEKLTAASNPDIEDEWQIVDKEDTQPDGLGKDEKKELVQEKPSDNSEKSLAEEKRELAKARWEGMQPQRGGVYPDREVKTPSYPQFTGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPI9</accession>
    <name>S0EPI9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437276.1">
        <property type="nucleotide sequence ID" value="XM_023570116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPI9"/>
    <dbReference type="STRING" id="1279085.S0EPI9"/>
    <dbReference type="GeneID" id="35404703"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11240"/>
    <dbReference type="HOGENOM" id="CLU_1147230_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="216" mass="22796" checksum="F43195B578FA1073" modified="2013-09-18" version="1">MTIGDFSDFDKAEYTHRISYYETDRLRKQEIVKTRQITAGIISSHIGGWGAVASSGGTLVLSAIAIRRVHVAESKLKLIRAELKKRDILIPLRACAAGMGVGLFPSDSIAHAFCMNPGDSIGGVAHGATQQLHEMGHAIMSLDNGSSAAQNLARVAISVPQTSVEEAVGFHTGMVAMQATERGLASVASSSLATQGMKAMTGDADQMGSAQSARYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPK0</accession>
    <name>S0EPK0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to aryl-alcohol dehydrogenases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437331.1">
        <property type="nucleotide sequence ID" value="XM_023570182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPK0"/>
    <dbReference type="STRING" id="1279085.S0EPK0"/>
    <dbReference type="GeneID" id="35404762"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11300"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="362" mass="40509" checksum="EE15D758484C025C" modified="2013-09-18" version="1">MSSSQHGYVKDLLIQPQATRMGYTRLGRSGLKISKIILGAMSYGSKDWLKWVLEEDEALPLLEHAFKAGINTWDTADLYSNGVSEEIIAKALAVYNIPRERVVIMTKCRFATSAPGEPQLSVFAASINDGEMVNRAGLSRKHIFDAVQASVKRLGTYIDVLQIQRMDPDVPREEIMKALNDMVELGLARYIGAGSMPAWEFQALQNVAEKNGWHKFISMQNYYNLLYREEEREMMPYCKDAGVGCIPWSPNARGVLARPWNGLDEKTSLRTQHDQTLSRLYDRENEADKATVDIVEEVAKAKGLPMAVIATAWCLHKGVNPIIGLNSKERIDEAVLAANITLTDDEVAKLESVYRPKPVTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHI7</accession>
    <name>S0DHI7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable DIP5-glutamate and aspartate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_01902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423690.1">
        <property type="nucleotide sequence ID" value="XM_023573539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHI7"/>
    <dbReference type="GeneID" id="35395385"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01902"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="54"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT61609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="577" mass="63129" checksum="E416B1BD2BDDCA27" modified="2013-09-18" version="1">MSGVEKGNDVEKTDLGYDASAAPTKDMGVGEDRHIRGLETSAETSLHRGLKARHITMIAIGGAIGTGLIVGTGKALAQAGPGSVFICYTLVGFVVFLVMAALGEMAAWLPMSAGFTGYASRFCDPSLGFALGWTYWFKYIIVTPNQLTAAALVIQYWVDRDTVNPGVFIAIFLVTIVVINYFGIRFFGELEFWLSSFKVIVIIGIILFSLVLALGGGPDHDRKGFRYWSNPGAFKPYIMTGDAGRFLGFWSCMVNATFAYLGTELVGVTVAEAQNPRKTVPRAIKLTFYRILFFYCLSVLLVGMIVPYNSEELAFANKAKTGASASPFVVAADIAGVKVLPHIVNACICVFVFSASNSDLYIASRTLYGLASDGSAPAIFKKTDKHGVPIYALAMSASFCLLAFMNVADDSTKVFGYFVNLTTIFGLMSWISILTTHIWWCRAKKAQGLANEALPYVAPFGMWGSIAALSMCILIALTKNYDVFVRDQETGKIFGGEKYKTFITGYLGIPVYLILIFGHKFITKSRGIKPHEADFYTGKDVIDREEEEFLAAQAAKREAEGPNRGGWFYKTFVSWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHP3</accession>
    <name>S0DHP3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to C4-dicarboxylate transport protein mae1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423606.1">
        <property type="nucleotide sequence ID" value="XM_023581894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHP3"/>
    <dbReference type="STRING" id="1279085.S0DHP3"/>
    <dbReference type="GeneID" id="35395479"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01996"/>
    <dbReference type="HOGENOM" id="CLU_030057_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT61525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="442" mass="48730" checksum="F07CF60BD22362BF" modified="2013-09-18" version="1">MSQPSDPQYDAVDGYARDINGRPVDIESGSSARDRAFPKNAPRPLRLRDRVVRITWSWFPCTMSTGGLANLLNEQPYTFTGLKTIGKIFFILNIILFLTFTALIIARFVMKPRAFSTSLHHPSESFFFGAFWVSIALILTGAQSYGGPETGPWFTTAMRVVFWIYYACEMVVAVTQYHIIFETERLDISEALPGWILPAYPFLVTGMLAAKVAGSQPQWSAVQIIVAGLMGQGLGWMLALFIYAVYLSRLIQHKLPDASKRPGMFIAVGPTGNVAPITILNLMLTFVAFTCGGLIALGTQAKSALPDDFLSTPNIPAGELWSGMSVAAGLFIWLMAIWFSALSAISVLRAARRMDFGLSWWALVFPNVGLALASINVGNTLSSRGIKIFASTLTVVLVIVWFICAAFHIRAIIRRDLLAVGKDLDVEHVNKQHDIKAEKQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI77</accession>
    <name>S0DI77_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to peroxisomal ABC transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_01735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423857.1">
        <property type="nucleotide sequence ID" value="XM_023575406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI77"/>
    <dbReference type="STRING" id="1279085.S0DI77"/>
    <dbReference type="GeneID" id="35395220"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01735"/>
    <dbReference type="HOGENOM" id="CLU_007587_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="173"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="527"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="747"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT61776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="810" mass="91301" checksum="028940F7D5C1373F" modified="2013-09-18" version="1">MAAQSTLRHTAAEEQLAAFLDKWTGKIKTRLRGTTRTTRLLATLALAISIILGGVGGRRWWKNRRHEREQGRKLVRTNSWLHNKDGSRTIYVPYKDGTSKVVINTTKPLTFDAHRRLFLNPPRVSGLREGTVPAAQTKPGLNIAFLHQFLSLMSIMIPRWSSKEAGLLVSHGVFLMLRTYLSLVVARLDGEIVRDLVAGNGKAFLWGILKWCGLGGFASYTNAMIKFLESKVSIAFRTRLTRYIHDLYLNDNLNYYKLSNLDGGVGQSADQFITQDLTLFCAAAANIYSSLGKPFVDLCVFNYQLYRSLGPLALTGLMSNYFLTASILRRLSPPFGKLKAVEGRKEGDFRSLHARLIANAEEVAFYGGADTEKTFLNREFKSLKTWMEGIYMLKIRYNILEDFILKYSWSAYGYLLASLPVFLPQWGGVGGRAEMVENGVRGGRERNRMKDFITNKRLMLSLADAGGRMMYSIKDLSELAGYTSRVYTLISTLHRVHADAYHVRAGQSELYSLSDVSGTIQKGFDGVRFEHVPVVAPGLWPQGGEELLESLSIIVRRGEHLLISGPNGVGKTAIARILAGLWPVYRGLVSRPKDIGQDGIMFLPQRPYLSPGTLRDQVIYPDGHVDMKEKRKSEDDLKSVLDAARLGYLPDREGGWDTRKEWKDVLSGGEKQRMGFARVLYHEPQYAIVDEGTSAVSSDVEGLLYETCKERGITLITISTRASLKKYHTYNLVLGMGDQGDEWEFERIGTEREKMQVEKELQDLRERLEQVDEWKKRRDEIETELAAVWTDQGEVLEAPTYAEKAAEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI94</accession>
    <name>S0DI94_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">FFUJ_01408</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424155.1">
        <property type="nucleotide sequence ID" value="XM_023579050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI94"/>
    <dbReference type="STRING" id="1279085.S0DI94"/>
    <dbReference type="GeneID" id="35394893"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01408"/>
    <dbReference type="HOGENOM" id="CLU_000513_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="224"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="761"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1026"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CCT62074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1175" mass="128974" checksum="92ADEF7F3937C9EB" modified="2013-09-18" version="1">MPLNFNLATTLAGRAPALLRHGRRVPRALPSRSFSSVSPLSASASCRVSIASARPANSKRLGTLKVMRAYSSAAVQDAPNPKAYLDSGVIKPHQTVDVKKVLVIGSGGLAIGQAGEFDYSGAQALKALKEAGVASVLINPNIATIQTNHSLADEVYYLPVTPEYVSYVIEKEKPDGIFLSFGGQTALNLGVEMQRLGLFEKYGVKVLGTSVRTLELSEDRDLFARALDEINIPIAKSIAVGTVEEALEAAETVGYPIIVRAAYALGGLGSGFANNEEELRNMAARSLTLSPQILVEKSLKGWKEVEYEVVRDANNNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEEYHMLRSAAIKIVRHLGVVGECNVQYALQPDGLDYRVIEVNARLSRSSALASKATGYPLAYTAAKIGLGHTLPELPNAVTKTTTANFEPSLDYIVTKIPRWDLSKFQHVKRDIGSAMKSVGEVMAIGRTFEESFQKAIRQVDPRFVGFQGDKFDDLDFELQNPTDRRWLAVGQAMLHENYSVEKVHELTKIDKWFLHKLQNIVDCTRELEQAGGLQSLKKDQVLKAKKMGFSDRQIAMAVKSTEDEVRAYRLSFGIRPWVKKIDTLAAEFPANTNYLYTTYNGSTHDVTFEDNGTIVLGSGVYRIGSSVEFDWCAVSATQALQQMGEKTIMINYNPETMSTDFDSADKLYFEELSYERVMDIYELENSKGVVVSVGGQLPQNIALKLQETGGANVLGTDPRDIDKAEDRQKFSEILDSIGVDQPAWKELTSVKAAEEFAEEVGYPVLVRPSYVLSGAAMTVISSQEDLKDKLEAASNVSPDHPVVITKFIEGAQEIDVDGVSANGELIIHAVSEHVEQAGVHSGDATLVLPPANLDSNTMERVKEIAVKVAAAWKISGPFNMQIIKAENPEGGEPLLKVIECNLRASRSFPFVSKVLGTNFIDIATKALVGKQVPAKSDPMAEKRDYVATKVPQFSWTRLAGADPFLGVEMASTGEIACFGKDLVEAYWTSLQSTMNFRMPEPGEGLLFGGNVSKPWLTQVVDYVAPLGYKLYAASPEVKEFIENKSKTKVEVEVIEFPKEDKRALREVFKKYDIRGCFNLAQARGKTTLDVDYVMRRNAVDFGVPLFMEPQTAILFAQCMSEKLPRPEGIPAEVRRWSDFIGGKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIF4</accession>
    <name>S0DIF4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_01519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424056.1">
        <property type="nucleotide sequence ID" value="XM_023577806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIF4"/>
    <dbReference type="STRING" id="1279085.S0DIF4"/>
    <dbReference type="GeneID" id="35395004"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01519"/>
    <dbReference type="HOGENOM" id="CLU_005882_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT61975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="924" mass="104424" checksum="EDE7490D70A7757A" modified="2013-09-18" version="1">MAPVEAEKFLSYEAGPEVEEFANALDDCLSPPLSNEERRERIIDLPRKYYENALRRLAQVRPRMTRNGQDDVDMDADDDGTNSNPASAELVKRLEREAQTWDLLRRLLPLRYASSDDGQSASKTEQSSVDSGDLFKSFLASDSSARERQAVIQWLQSNASSGPDVNELAHELQQNADRGDIIAHGWLHTRSSIKLRKGVTAWPHLLDRQSPAIATSFHTSDGSPLVTQLDPDAATRQGRKLEPQDEYFERAIWLGCWEHLRRGSSLESIREWCQERTEMWRAISTSAILLSADDSQGVTDTKPASLALWRRMCFSLSRSGGCDDYERAVYGVLSGDIPSVEKVALNWDDFLFANYNALLRTQLDNYILGQCPADVASNLTQSFPSFDAIQFHGEPSTVDMRLIRALEANPQIKDEANEPNKALQASLISKEIGQHLYQQGFIISSGANHNESALYRSEPSKLEVNKERFFQSTQHYGLRIVAHIYLLINLLDKLNSKDDSLAPAYSPPEMRRSQQNLIAGYANYLRLAEFHELIPLYCSILEPPRSYEVLSYNLIPENEASRRLLQLRLIRKAGIDVLEFVKTQAWLLFDDLGPAQHGCPAKEGFSIIEPGPPTSRSGRPVRPDFFGDDERFVDQAHENLIRSLEWLVLVQETWPNVLSMGTKIYKFFLRNMHLSAARQLMKRVPFSEVLHAATEENGDEIELYEDIPEFWARQLDRRGIRDVTPQQALSDARNFRELENLVRALDSLETVASLAELTNEYAKIENPGAGTANILTTDRDQKKNREFWNAIGDEVKNTKENMQPLLKNWLLVGIEEGDQELQDLRQAYLPETVLAYVGTLHFAGTGLSRDNLLECMELASIVAERDSDLSVAFLEAGRMKELVEVFAASSKALAISTGEKRTASTGSKKLREMGWSRDLWSVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIJ3</accession>
    <name>S0DIJ3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_01188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424355.1">
        <property type="nucleotide sequence ID" value="XM_023581517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIJ3"/>
    <dbReference type="STRING" id="1279085.S0DIJ3"/>
    <dbReference type="GeneID" id="35394673"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01188"/>
    <dbReference type="HOGENOM" id="CLU_050172_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10308">
        <property type="entry name" value="GST_C_eEF1b_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000001">
        <property type="entry name" value="Putative Elongation factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="8">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="7">
        <location>
            <begin position="144"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT62274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="230" mass="25137" checksum="9D70C1CB0CCED33B" modified="2013-09-18" version="1">MGFTDLVSDAGLTVLNSWLSTRSYIVGQSASQADVATFKALSSAPDAEKYPHAARWYKHIASYESQFATLPGDAAAPYTTYGPETAEVTINPAQAPEKAEGGDDDDVDLFGSDEEEDEEAARVREERLAEYKKKKEAKPKTIAKSVVTLDVKPWDDETDMVALEAAVRAIEKDGLVWGASKLVPVGFGVKKLQINMVVEDEKISVADLEEEIQELEDYVQSTDVAAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ09</accession>
    <name>S0DJ09_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424570.1">
        <property type="nucleotide sequence ID" value="XM_023569274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJ09"/>
    <dbReference type="STRING" id="1279085.S0DJ09"/>
    <dbReference type="GeneID" id="35394443"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00958"/>
    <dbReference type="HOGENOM" id="CLU_022488_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="751" mass="84732" checksum="1894DE48AF443729" modified="2013-09-18" version="1">MIPHRNRHHSNGQYESRHRISASPEFYSLDVESSGLDTVQAWLSQVHDYASHKDPEPQFAQDLDGDHTPNWKPNWKPNWKPHDLSAVPISRNYHQSRHSGNRAFDQRPTSPKSDLLEHDTYSESQHEPSLDIGSDKENGMRSRSRFKQDCHKERSNKTLFERQPRRKTRPDRYTFKDTGGKRDHTIESEEERPRKKSRSKKQEIRASRDIMNNFASGAIPDTRVTMRPNLTAGLFLNGRSSTYGRGADITLDDMTFIETCGEKGKPDEILQHLTSENSSGQDVSNSDHTSRSATELPITTTNDEEGEVQSLADDISQGNQQKNIQKDGFEAHSASVRSTETTQTSDYKTPEAMLKRLIETGIFDGTGILETTSHRTMEPNIEHHDCLGMNGTKQSSKNPTYQDKGVMADRSRQSTLEPNIQAATKNTQFHLNGGAKSAPVPTKASCSRYEQELPVPISSTSPQVQPSILPTSVVENNTHSIPEEPCVKQPLGTKSISSTNNRGQPLSRISERGYRYTEQNDRPGLMFPSFIAEGFNGEHSYHRGSTEEDEPQLEGSFVHRGLQSHDIMIPVSGSPGFQQPRRPLNGHISSAGLDSAVFPTVHSDIYSDHRDIQHDDRQLTQPDYCEDSETIQEFIKRIEGEVSMKWDNSQQSVGVGCISDIEECAKSESFEMDNSEDLPQCSDVDHDGVIQQSLHSIFSSFDQGSISTNQAMAEDWEHSDYEQSRYWTGKYHDEHGVSEAEMVGFWRPNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ34</accession>
    <name>S0DJ34_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424386.1">
        <property type="nucleotide sequence ID" value="XM_023581883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJ34"/>
    <dbReference type="STRING" id="1279085.S0DJ34"/>
    <dbReference type="GeneID" id="35394640"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01155"/>
    <dbReference type="HOGENOM" id="CLU_005053_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="589"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1141" mass="125079" checksum="572B36F3E754C2DB" modified="2013-09-18" version="1">MTSSRSFRASIMPSMLRSNTDPDSSSSPRKSVKKSNTSDLAHLRGSNIGSSKSTTNLPHMGSNLQQDQDAVQHNRPRSAEQKTLRKRNDSTQKVSLPKSQSTTNLSPTKGSTRWRNRLSSFLPSLVLPSEPSPKSVPTPPVPAAPSAPASAVTAAVSPAPTKSSSPTDTSTTTNTAATPPTTVDDSASSTTPSIIDPTVRMTSDFHDALTHQAHGQYQPGHTGSPPSPDSIPTRGSDSLDGPLNPQPQIMAPIPPSPEVQRATMSPQEPNMPPPPIPTSPSDNVSSGSGKLRKENPAARSRSGSLQHTSSNSNGDSIQALKTRQTSPAPDRGRRASSVQSPNSRNNNTKSRVVSTPLAIRPGSSKGDASQSPTRGRLRRSWLPGGRSRSNSMDVSNTNASTAWVLSDDTQAEYNASFLKNGEKVPELWNESGAVLVYLYPKGSGFGPSFKVQEFTISSSWVFNELIQREREMPMGRDRTRSFSGRDSLTAEDANRFISSPASPPVPDDGYDDCLHLYLPNGTPGQETPPDMDRLIAIRNLFAFLTGQPLVATKARPTNFHAFLEISKLLEEYGFTSYDGTTFGDAVDLSFGFYMDQHALADCRNSREKTLEALILGERMRSADLYNEAFAHAAGKLPAIQDLKLPLWNQVSEKTRTNLERASTDLNNRQHNANMHLEQFEFPALFSGIANSTSMSELRSVRFKVWKQSFTKMRNFALSYYKTAFGNWPPKASSKKNPFSESGLNRLVLKVLYSDMCALYDLLVDRTNRTSRIMDAVPELSNDPDKMIMSALRNIMSEFDRSKPPVLPPIPYDCPQLPTATSILETYDTLSPKKQAKFDKNLKEHELMLMLNKAYNYDTNATKVPFLDKFKEFELREARGKTPQDFADQRIGYWLFLYVVIQSLPVLVVDAPGMQFTEGVEYFLCEPPLGNPPWVPDQQVKKMWYEVAGTGGLVELSQDAVLFSVEATYHRSHCWLAATQWESGASGLQAQAPTEPSLSPLQPPRSMFLDEDFMPTPPPSFGNGYNTPPSPIGSPSGSLRPRTHSPGGNRANQAWRSSIALGLEPVPLQPPSPFGERSSSLGGRPPSLMMGSRNSSVGNLAAFGHQGFPQTESPPPEQTGATFDDILRSDAMKKEKKKSRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJV9</accession>
    <name>S0DJV9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to TRM9 tRNA-methyltransferase modifies uridine residues at the wobble position</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424692.1">
        <property type="nucleotide sequence ID" value="XM_023570785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJV9"/>
    <dbReference type="STRING" id="1279085.S0DJV9"/>
    <dbReference type="GeneID" id="35394307"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00822"/>
    <dbReference type="HOGENOM" id="CLU_029501_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="92"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT62611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="280" mass="30689" checksum="FB59F1BF5F1C43D0" modified="2013-09-18" version="1">MASASSATPAGDQEDRPLQQPSSQAQTNQTSAPTESESFSQSAAEEAPETYEATHVHAVYEAIAPHFSATRHKPWPRVASFLLSQPPGSLGLDVGCGNGKYLRVNPSVHLLGSDRSPALVQLARTELRRPREDGVEHNPRVSDVDVAVADGFALPYRNGAADFVICIAVVHHMSTRERRQAAIAELLALVTPKAGRVLVYVWALEQASSRRGWDASSDQDRLVSWVMRKPKGQEPGGTFQRYYHLYKEGELEEDVKAAGGIVVETGYEKDNWWVVCSRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL62</accession>
    <name>S0DL62_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-xylosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424158.1">
        <property type="nucleotide sequence ID" value="XM_023579083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL62"/>
    <dbReference type="GeneID" id="35394890"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01405"/>
    <dbReference type="HOGENOM" id="CLU_095402_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT62077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="17159" checksum="EFF7D7611A6AED4E" modified="2013-09-18" version="1">MMRGEIPSRHHRALGQRRLAKNPNLQRKLEQMALPLAPLVQLTTGAVHPSFPTTVLNFWLLTDEQLESLAHFYHQRTPSPWTNQYPCPVTWRSDLPLEEKRRKMGKFIGLRGCESPILLKTEEEILAEARKARLAAEEDLWRRKHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLJ1</accession>
    <name>S0DLJ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424303.1">
        <property type="nucleotide sequence ID" value="XM_023580883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLJ1"/>
    <dbReference type="GeneID" id="35394729"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01244"/>
    <dbReference type="HOGENOM" id="CLU_2757826_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="70" mass="7543" checksum="BC1E140380B47F8D" modified="2013-09-18" version="1">MPKSRGKGKNCTQGERVEENSDNLTESETTPMPQDTIDLLSNFLGVVKGSDSSDEDKKSALEALVQSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLK1</accession>
    <name>S0DLK1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425570.1">
        <property type="nucleotide sequence ID" value="XM_023573616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLK1"/>
    <dbReference type="STRING" id="1279085.S0DLK1"/>
    <dbReference type="GeneID" id="35393633"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00148"/>
    <dbReference type="HOGENOM" id="CLU_007383_12_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="165"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="345" mass="37848" checksum="4C69B345DBC4BA76" modified="2013-09-18" version="1">MSPTGTTGFIGGDAFYALHKAHPDWKYTILVRSEDKGKDVQKQYPDVKLAIGSLDDSKVIEKAASEADIVVHTADSSDHQGAAKAIAAGLRSTHSSSNPGYWIHISGTGILCWYDMDNKRYGEGPLPEQAYNDLEGVDKVTSLPDTAFHRDVDKIVLDEAAKDPSAVKVAIVCPPTIYGTGRGPSNQRSRQIPGLTETTLEKGFGPIIGAGETEWDNVHVHDLSNLIVLLSERAASNEKHSDEQEIWGPKGYFFAENGKHKWSQISALIAKEAKKQGVIESDETKVLDVDEAQKKLGFQALSWGLNSRGEAKRARKYLGWKPEGESLEEWIPESVQIEAKRLNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMD2</accession>
    <name>S0DMD2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT63595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023571358.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1279085.S0DMD2"/>
    <dbReference type="GeneID" id="35398739"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05258"/>
    <dbReference type="HOGENOM" id="CLU_071330_0_0_1"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27800" checksum="83C9CF6D11E7DC1A" modified="2013-09-18" version="1">MKVVIAGSTGFIGKEVVRQALLHPQITSVVTLSRHDHDLSEDLQTPEIESKLTSVTCSDFKNYPQYVKDEISGADACIWLIGVTPGKLKQYEWDQVRMICYEYALYAADTFAKLPREGNPDPLRFIYVSGCNAERDPAKKPWILGDYCLLRGQVEKQIIERAHLSDGRMQVLVTKSGMVNDPDMGFLKQGLRWFSHAVINIPNIGRKELGAGLIEQSITGFGKDTLSNAEMVEIGKKALEKNEILEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN78</accession>
    <name>S0DN78_GIBF5</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424933.1">
        <property type="nucleotide sequence ID" value="XM_023573165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN78"/>
    <dbReference type="GeneID" id="35394038"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00553"/>
    <dbReference type="HOGENOM" id="CLU_066070_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="278" mass="31402" checksum="4EFEC6016AA15444" modified="2013-09-18" version="1">MAPVRRYLRISKYSVLECRIYLDNPALAQSWLLNPRDPVLPKVIEAIRPLVLPKLREEKERIRKKSKKKSIKDVIVSDEFEVSIFLTETSTRHSLLYKTKHFRDKLPPKLESNSSKLIGETDSVPVDVEDDYRAPVLQEDDDDEVRLADIPVAETTTRRSKRQRRIQGPEQDGNDEAFDDDETASTIEIDSDTEAPPHKRQRARTNDGLDGNEDKKKLAMDVSYEGFAIYGQVLCLVVKKRVNTAASSGGGGKARPEGQATMENWISSTQVPVGEDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNI4</accession>
    <name>S0DNI4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_00433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425043.1">
        <property type="nucleotide sequence ID" value="XM_023573299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNI4"/>
    <dbReference type="STRING" id="1279085.S0DNI4"/>
    <dbReference type="GeneID" id="35393918"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00433"/>
    <dbReference type="HOGENOM" id="CLU_004083_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="806"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT62962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="950" mass="106355" checksum="BAC79343FD22E37C" modified="2013-09-18" version="1">MSGYLEGLALGFGYNVSEGLDSAQQSTASPSSNTQQDASSHTQPNSFQGNVTVYQTTGPDAHTSPIHLPGSNTPALNPRSCVTCRRRKVRCDKQMPCSNCRRAQIPCVFPAPGRAPRQPRRKDPNAPTKNSSQREMELMKRLRKLEGIVEELSGQIEVESGGKGPSSTNSPEAHAGQSTSFEASAHNTQRQSSNAGSHAGNIGRTDDSPRGSDATSEQSETARKNMHKKFGRLVLSDTGGSQRYVSHGFWSKLNDELDSIREETQKLTDEDLDESEEDETPDTSPASALSGNHNAWIFGYRSADVDLDKYWPLPSHIPFLWSVYQENVEPLLKVLHIPTMEPIFRDARKDHKQLSPANEALVWSIYYAALTSLEPDEVRANLGLNKEDVVVQYRFAVEQALAKANFLNSLETPIMQALIIFILVVKGQDGSRFCWSLTGLVAHLAQGMGLHRDGSHFDLSPFETEMRRRLWWALLLLDLRSADELGTDLIIQDFNYDTQMPSNINDTDIKPDSTEAPEPREGHSDCSLALVRFEIAGFGRRLVRLSSASMSFCPQGMPYKDTSLAERERMLIEVYNRVEEKFLKHHTGDSDPLHWMAASIARIIMAKMTLVIYQPVLFPGSEGEGTLSEEAKERAYVAAIEIAEYNHILNNDSRSKQFRWLFKTYTNWSAMAYFLIASCRRPWTPLVERGWEAVSGYEGGPGQLVRSAEYATVVMPIRKLYMRAQRHRAAEITRLRGNPEEARRLEFEERTNPRYQARFGQDADGAVNKMEEIREKWKALVRSDGSNVPISTPAELSPVMPLSMLQPKQEQTPSRPRTPSAYDVPGTLDLSDTTMGYMNDLMADTTPFPMVNFWPLQDVGSVQIKAMGTGMTPMQNTSQLPQDATQPGDTGQHFSPQTLQFTKDDNPPPYLWGGQFPSINSNFDNTGLDDVDMLGDDFNWHTWSQNVRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNW1</accession>
    <name>S0DNW1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_04519</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426355.1">
        <property type="nucleotide sequence ID" value="XM_023572185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNW1"/>
    <dbReference type="STRING" id="1279085.S0DNW1"/>
    <dbReference type="GeneID" id="35398000"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04519"/>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="40"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT64274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="406" mass="44083" checksum="416A46CBD2F0E4ED" modified="2013-09-18" version="1">MAPFNLESSISLRARACCPSPALEQRLTFPSDYKDDGTNILLDANENAYGPSLSSDVAEKAANGVEVDLLGLHRYPDPHQEPLKKQLCELRNTHAHTDKTLKPENLFVGVGSDEAIDALLRCFCVPGKDRILTCPPTYGMYSVSAQVNDVALVKVPLLEAPTFSIDVPAVMEALTKESNIKLVYLCSPGNPTGSVLAKSDVQQILDHPTWNGVVVLDEAYIDFAPEDASLAEWVTEFPNLVVMQTLSKAFGMAGIRLGAAFTSPPIARLLNSLKAPYNISSPTSALASYAVSEKGLAIMRDHRARLLEQRDRLIKELPKIPGVGRLRGGTESNFLLYEMLNSASEPDNTVALAVYEKLAEGKGVVVRFRGKEHGCQGCLRITVGTDAEVTRFLESLKTTLAEVRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP06</accession>
    <name>S0DP06_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_00261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425203.1">
        <property type="nucleotide sequence ID" value="XM_023573490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP06"/>
    <dbReference type="STRING" id="1279085.S0DP06"/>
    <dbReference type="GeneID" id="35393746"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00261"/>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF134">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="496"/>
            <end position="497"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="564" mass="62259" checksum="89DD777759308AE4" modified="2013-09-18" version="1">MASPFDFIVVGGGPAGSALAANLSGTAKKPSVLLLEAGGTNQDRNLRVDGQRWTTFLNQDMNWGYKTAPQEFANNRELDYSRGKGLGGSSAINFGVYSIGARDDYEEWARIVDDDAYRWDKIHGRYKSLETFHGELPEGVDKKYAAPKAEDHGSEGKLHVGYAGEWEKDLPPVLDLFEKAGFPLNPDHNSGNPLGMSVLINSSAKGRRSTANDLLEPKPENLTVLTDSTVQKVLLEGNKAIGVEVNGKKYLASKEVILSAGALNTPKILMHSGIGPKSQLEKFNIPVVKDVPRVGQGLRDHMFTPLVYTRKPGDTARDTFYGDKKAMDDALEQWRHDGTGPWTKFACELGIGWFKLDKLVKSDEFKALPAEEQEFLMKETVPHYEILTHFPIHWFIPQFPDSALNYSCILVFYYNAQSQGEVTLQSSDPNAPLRFDPKFLASPFDRRVAIESLRDAFRLVKHDGYAKDNVAMLAGPQGDSDDELLEHWKNTISSSWHMTGTTKMGKKGDPDAVVDSDFKVIGFEGLRIADMGVVPVLASCHIQSVAYVTGVTAAEKLIAEYNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPR6</accession>
    <name>S0DPR6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_01425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425488.1">
        <property type="nucleotide sequence ID" value="XM_023578850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPR6"/>
    <dbReference type="STRING" id="1279085.S0DPR6"/>
    <dbReference type="GeneID" id="35394910"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01425"/>
    <dbReference type="HOGENOM" id="CLU_008279_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000075">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase creB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="58"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="550"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="580"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT63407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="732" mass="82013" checksum="8285A6717A2C15BD" modified="2013-09-18" version="1">MAGFFNKIKGSGTATTTTPSKQDVVAKKKEEPVLDLTPLEKMLQNAAPLRDDGADRFFGLENFGNTCYCNSIVQALFYSESFRNNVVNYPPIMPLETNGGRPRVPITIRPPPTDPVETLPKQKGLSTSQVIKQRQAMNQQLPGQVGVRPEDKPDTPEYKKKQAMIKGPILELARENATSYGMNECTFTGLKDIFLALLESNTHTGVLSPQRFLEIFKRDNEMFRNSMHQDAHEFYGLVLNDVINSVESTARQMQLQAPADGIDGLATSVGHALGSAMVNHVAGSSSPATGWVHDIFEGVLTSETKCLTCETASQRDETFLDLSIDLEEHSSVTSCLRKFSAEEMLCERNKFHCDHCGGLQEAEKRMKVKRLPKILTLHLKRFKYTEDYSRLQKLFHRVVYPYHLRMFNTTDNAEDPDRLYELYAVVVHIGGNAYHGHYVSIIKVPGRGWILFDDEMVEPVDKNFVRNFFGDKPGMATAYVLFYQETTFEKVREEQEKEGMEEVKLASEAANLAQENGDKLDTAPLRRQATQPMSPLTHHESMANLAHASTAPAMPSAPQPDPAPPAAAAAATNGLTRVTTQKEEAKSKEDKKREKKEREAAEKAEKLAEKEREKQAKVDEKKRREDNYKAIQARRNENDELAKVLEASKKSAAQEEEARKKENGTPQSNGILDRTKRGSKSMSRRSFSLFHKDKSAGQTPDTPNGDAGDKHDKLKDRLSFSLGRKKSTNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ02</accession>
    <name>S0DQ02_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424729.1">
        <property type="nucleotide sequence ID" value="XM_023571230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ02"/>
    <dbReference type="STRING" id="1279085.S0DQ02"/>
    <dbReference type="GeneID" id="35394267"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00782"/>
    <dbReference type="HOGENOM" id="CLU_054590_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="293" mass="32042" checksum="237A6CE7D2C96EB8" modified="2013-09-18" version="1">MLVKESHVDVPTSANGKEGTMRMSSSTLTICDMRSLPTYTRDQASLRFPGVSLFSEIYQVTGPVARFARQIAGQGYIVAAPSSYHDFTGPEPLKYDAEDTDRGNKFKIEKTLESYDADSYATVDYLLSLPTCTGRIGATGMCLGGHLAVRAALDPRISACVAYFATDIHSRTLGPYDAPNTSSTAPPNSNHTIDLFNKFKGEVAMIFGVKDTHVPDAGRDLIRAKLREAGVPTSFYEFAWAQHAFIRDELSKGRYDPAITKVCFEVLLELFGRVLKTDLGAKDGDVPPPEHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR82</accession>
    <name>S0DR82_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427047.1">
        <property type="nucleotide sequence ID" value="XM_023573026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR82"/>
    <dbReference type="STRING" id="1279085.S0DR82"/>
    <dbReference type="GeneID" id="35397246"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03765"/>
    <dbReference type="HOGENOM" id="CLU_669112_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF123">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="360"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="411" mass="46163" checksum="C3696B7B0CC6AEAE" modified="2013-09-18" version="1">MSNSPQMLEQVTRGRPLQPSRANAPTVSFNVAIEQAKLSFPDELLFDKWESSHGSTLNGTKATKTEVNDKTNVSSAGIDNFTHFTDVKLDDMNLKWDEIIPADRLAEMKTEEQQKKEEAYIGTIVAEGAPRKASIKRGNIIQVLGSLPDELPIREREIYKKNSLLPRSAEAGPGYPPPQAHGPLPPHCNTDKLLDCRLRSTHYTISQDHTSGKEAHEDNLLAIFGKRRRTDKPSISLGGRRLLQRSPNLLPSLANDNDVVAQDEGHRTQVISTDDLDSLGNWQPVDSKIPEDTVSFPEETATTKPNEGRDRRDEVEFEWVRNKERRRPVQSRPEIPVPRSQQSFRADTSRVNKSGDGPQATLKRRCHSCNRSDSSAWRRGPDGARTLCNACGLHYAKLEIKRMLERKLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRR7</accession>
    <name>S0DRR7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427355.1">
        <property type="nucleotide sequence ID" value="XM_023573911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRR7"/>
    <dbReference type="GeneID" id="35395689"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02207"/>
    <dbReference type="HOGENOM" id="CLU_005562_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="506" mass="56986" checksum="0A5369C44B5F75DC" modified="2013-09-18" version="1">MSFRFPYHETPSESSFNREFNDAEKGQHDTSGMALVPLSKVYASDKANGHLTAFPPTHDANMASATQSTSSFHNYSKSDSSLPILPKQKTTPPPPKKQEPRKSTLFFLWFNTVGQFQYAQDHLGSMVLGNLLFAILMRNELFFRILYMAFIYGLRSWAPLRMKLMAASFLQHVGGVHSGCALSGTAWLVYYIIQILSHRSIREPAVLITGIVTVVFIITSVLSAIPWVRNNHHNIFERYHRFAGWLGLAATWSFVVLSNSYDANSGKDNSNAQSLITTENIWFTIFMTILIALPWVTIRQVPVEVEIPSTKVAVLRFDRGMQQGLLGRIGRSALMEYHAFGIISEGRHSPYHYMVCGVQGDFTKSLVANPPTKIWTRELKFAGIGHASAMFKRGIRVCTGTGIGAALSTCIQSKNWFLIWIGSDQLNTFGSTISRLIHDNIEPDRMILWDTKERGGRPDTMQLLRDTWNNFGAEVIFITSNMKGNDEMMQGCREEGMHAFGTLWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRU2</accession>
    <name>S0DRU2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trichothecene 3-O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425364.1">
        <property type="nucleotide sequence ID" value="XM_023573690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRU2"/>
    <dbReference type="STRING" id="1279085.S0DRU2"/>
    <dbReference type="GeneID" id="35393569"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00084"/>
    <dbReference type="HOGENOM" id="CLU_026450_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="454" mass="51060" checksum="92943AFDBA92BF20" modified="2013-09-18" version="1">MTALNTTNMDELDIELDIIGQQPFMVKIYTQISFCFPITDPSTHPAITATLKTGLQRLSQSFPWVAGQVKDDGTGVFKIKPFKETPPLVVKDLRDDPSAPTMEGLRKAEFPMSMFDEKKIASKKTLPFGPDYSPDDPSPVLMFQLNFIEGGLIFTVNGQHGCMDMTGQDELIRLLSKACRDEAFSEQEISTMNLDRKTIVPLLENYELGPELDHQIIKPPPTTETPPTPPKASWAFFSFSSEALCELKDKAMQSLDGQSKFISTDDALSAFIWQSVSRARLPRLDDSTSTQFCRAVDVRTQLDVPKTYPGILQNMTYSVSNLSQIAHEPLGIVASRLRSQLGRDDLRRRTQAIVTYLQDQTNRANVSVTADANPSIDIMLSSWAKLKCWEYDFGLGLGNPESVRRPLFEPFESLMYLMPKRPDGEITAAISLRDEDMERLKSDEEWKKYGKFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSP2</accession>
    <name>S0DSP2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427552.1">
        <property type="nucleotide sequence ID" value="XM_023574142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSP2"/>
    <dbReference type="STRING" id="1279085.S0DSP2"/>
    <dbReference type="GeneID" id="35395896"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02414"/>
    <dbReference type="HOGENOM" id="CLU_527883_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="516" mass="57548" checksum="465DBC63A0343DD1" modified="2013-09-18" version="1">MPLQGSAKARTRSVSNPSSWRNRSQPSTPVSTVFPGLGVSQSAHRQGLPAWDRTLDAVYHGTFEKGSFENVLKSFYENHARKKPSSGYFRLPDSVRYRICRYLLPPCDKPLRLNKHALSRDVWRKEDFESPSSTLLQISSYFEVSFDFRADVLVTFVQNTKLHAVLSPFTGPRVSPLATTWLNNYGMYANNIVIELDMTHLGCGSDPGAVALSPNVEQIEKLLQDFINAQMKRKESCPMESLILLCRRFHGRRPQAAIVSPPRAISSRPGSRPASRSASRSAKTPEPRSPTATTPRRFNFDEDAGGLRSPTLPDAISPTYPTVAPVEEYCPDSYLHFCNNILHLKGRIGSVRMCGFSEKYTAPFMGTLFSNNSKITKRYAYRVAPSTIWPKLAGQKSYIDTGDGNLALDDHEVSATNDIPSSLRIWEGCVQLPPPHIDASGDLILPAIVGDLQKLRSTRERSATSLSERTSEDLRKEGSKGDTLDKRTIAWFKSNYGKGKLKKKKRVLSRDAATTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT06</accession>
    <name>S0DT06_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425809.1">
        <property type="nucleotide sequence ID" value="XM_023571516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DT06"/>
    <dbReference type="STRING" id="1279085.S0DT06"/>
    <dbReference type="GeneID" id="35398597"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05116"/>
    <dbReference type="HOGENOM" id="CLU_021598_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="536" mass="62254" checksum="8E6A700F531FD273" modified="2013-09-18" version="1">MTANDEGRGSSGLLGRLPAEVLNEILCELQNIDLKNLRQTCTYFKDVVHLRLSRLFLSPNLRDIEVFRAVADHETLRFQVTEIIYDDARFDSAHEMEWFSWYNEERDIGEVTGVPDWYRHVYRENRNMVERAKPRHRQVKEAFEHLLSPAEAFKHFKRLWQEQQDTIATNRDADALKYGLLRFPNLKRVVVSPAAHGKPGLPWYLTPTIRSLPRGLLYPIERGWPLIRMHSNFPEAKDWDSSEKDKWRGYCLVSRIIAQHLRENPESKLADLAIDVNHLRTGISCRIFDDAENSEIKDLNTILSHTGFAALNLSLHCGNQCNMNWCSFRSNHLRNTLSKARHIQNFNLLTNVVYVDDFYYDSDDPDEDRDEGDHFIPLQSIFPVNDWHQLRHFGLCRFIVKKDDVIEFLGALPPTLESVELSFFIFMPDSGDYHSLVHDMREKLGWRGRDSENQPKIVVRVDVSFGRVYGAVMMDVSREVTNFMYQDGKNPFSEDEGCVEDPYIPQSDTPEGNGRLLDAFDPSFEEPNVSRLAMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT35</accession>
    <name>S0DT35_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_05084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425839.1">
        <property type="nucleotide sequence ID" value="XM_023571553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DT35"/>
    <dbReference type="STRING" id="1279085.S0DT35"/>
    <dbReference type="GeneID" id="35398565"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05084"/>
    <dbReference type="HOGENOM" id="CLU_028200_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF151">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT63758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="399" mass="44198" checksum="04F8DB489E0832E5" modified="2013-09-18" version="1">MAESQLPGLPGFDKHNIQPWTVEVVVSMTVLALVSCGLRLYSRHLKAQKLWWDDYVILFSMSWNLVVVGFIFAMHANGMGIHADKVPPSQIVKMAKWLVVAEVLYAWNLGWTKLSLLLMYYRIFRVPYFKKMAWLVGSFVFAWVITITFLFIFICIPVAKLWYPDLPGRCINQVGTWIANAASTIFTDIVILCLPLPPIWKLQLGKSEKLGLTAAFAIGSFVVFASAYRTSVLFTYTSTDPSYTLAPTVGWTEIEMSAGIVSANLPTMLPVLRLVAKFTGLSSFASTVRSNVRPSGDKSTKGLKSHENTGAGRSSNGSASTNAFYRLPDDNDSTDLIKGPKFTETSAPVNTKLRPDVEGFELTTTTYNAKVDGGNSSSEEILQGIRVHREFHQTTARSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTN0</accession>
    <name>S0DTN0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to G protein coupled receptor like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_04905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426004.1">
        <property type="nucleotide sequence ID" value="XM_023571754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTN0"/>
    <dbReference type="STRING" id="1279085.S0DTN0"/>
    <dbReference type="GeneID" id="35398386"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04905"/>
    <dbReference type="HOGENOM" id="CLU_024810_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT63923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="467" mass="52759" checksum="2F4F8D9D2EA26B32" modified="2013-09-18" version="1">MSHKFVVGRGMQSIELEPTQRTTLVLFERIGGSISLVAVLCIFVAYALVPKVRNVQNTFIVFASVANVGASVASIIALDGLELGVASPLCQAQSFMFHMFMQSDPWWSLAMAFNVFLVFFFRAKPDSFRRWWWIYCLICYGGPFAIAMALLLVRNPNRGLVFGEATIWCWVNQDWEGIRIYTYYMLVWVCIAGSILFYFLVGYHVFHTRNQLKSLTASRSREPAPFEPPQPQAQRQVEFLSVPQDCFYGTIVTEVQVVHSTPSANHLPSEPKPAYTAGPSSPQVSFDENPHVAQGSHSHYFSTSISPGIDSRERTSMSPLRRITSATNRTVNKFVIDDPIKRAYLRTSFLFALSVLVTWIPSSLNRIHSWLVGTSPYEYHVATAAVLPLQGLWNAVIFFVTSGKPLREWYRNLRYPQAQDREMIETRVEHDEHVGRSGESFLDDTDSGSDVELRRMGEAPGKRSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU56</accession>
    <name>S0DU56_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_03101</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023574911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU56"/>
    <dbReference type="STRING" id="1279085.S0DU56"/>
    <dbReference type="GeneID" id="35396583"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03101"/>
    <dbReference type="HOGENOM" id="CLU_019713_2_0_1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="650"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="261"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="395"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT66104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="702" mass="79987" checksum="45E1D1158A97182D" modified="2013-09-18" version="1">MEDRKRPAISSADDIAPPSKRVAVNGSKAKDDSSDMKEESWIEAYTKGAIYRQMQEYSRKASTYESRLEELHKRSVHHDDHLRLIDAWWRQVLEEMELLSDSEITSTTPSEPPYLSGVTFKDLHEFQKHLSDKGKTIKSRAEALLGRLASSRGKIDPDAAALENKVASLLATQKEYLFKLDRLKGEKDQLSEQLNAATLRYFKAEKKLDRAKSAQVQKLEQQAFANATRPSASGDGSAEAGETNGNAGELLLKYEEATAAATKQKEQLDIILAEIKTLQDENSTLKAKRETLTDEDFIRTDVFKQFKNQNEDLIKRINTLEATNKQLREEAEKLQAERSMFRTQLEADANQVTQELEAEIISRDQDLARVRSARDELLAETTQHKARLEQDRASIDQVKALASAKEDRITALEAKLSRLQPNEDQQAIRPDIEALTIDELRLQYTKLERDFNSINTEFPAMEKAYKKIIQIAQKKAMDTSAVEERMAILIAEKSKADQKYFAARKDADTRNNEIRSLRHQNSKSSEIIAQLKDLESQNRTLLGNLDKQLTDFKQANAALMTENKKMETASLDALRRTESLNKQIADLTNLVKSKDAASAVVRERNTMQETEVEKIKVRLEHAQKDRDNWKNKALSNASEEEEMLRTFALCTICRINFKNTALKTCGHLFCNQCVDDRISNRMRKCPTCSRAFDKMDVMPVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU77</accession>
    <name>S0DU77_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426179.1">
        <property type="nucleotide sequence ID" value="XM_023571960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU77"/>
    <dbReference type="STRING" id="1279085.S0DU77"/>
    <dbReference type="GeneID" id="35398200"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04719"/>
    <dbReference type="HOGENOM" id="CLU_008705_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905754">
        <property type="term" value="C:ascospore-type prospore nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="841"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="898" mass="99860" checksum="C8BA89476C39E28D" modified="2013-09-18" version="1">MAQDSEVPKAADKGKGKAVDDAKKDKQQTNGKKEEEKIETAEEELNEEDQQLKNELELLVERLTEPNTELYKPALEAMKNLIKTSTSSMTAVPKPLKFLRPHYESLTKLFEQWPKGEDRTSLADVLSVIGMTFSDEDRQDTLFYRLQAPSSDISSWGHEYTRHLALEIGEVYGKRIANDESTKDLIDLALVLIPLFLKSNAEADAVDLMSELEIIEEMPKFVDENTYARVCLYMSSMVNLLTYPDNETFLKTAHDIYMEYKQFAQAMVLAIRLHDYELIKSDFDKAEDPALQKQLAFLIARQRIVIDADDQSEENTALVESVGNLKLSEHFKSLGKELNILEPKTTEDIYKSHLESSRVAGMTNLDSARHNLAAAFVNAFVNAGFGNDKMMLVDGEKETWVWKTKADGMMSTVASMGTLLMWDIENGLDKIDKYTYSSEAEISAGAMLAIGIMNSGVVMDSDPAIALLADGDKLYHPNPLVRTACIMGLGLAYAGSNKEDVLEHLLPMISDASVDMQISAMAALSCGLIFTGSSHPEISEAIITTLMDDDRKNQLTDKWTRFLALGLGLLFFGRQEEVDVILETLKAIEHPMAKSTAVMAEICAWAGTGAVLKIQELLHICNEHQEESEEKRGDELLQAYAVIGIALVAMGEDIGQEMVLRQFGHLMHYGEANIRKAVPLAMGLISPSNPQMKVYDTLSRYSHDNDPEVAINAIFAMGLLGAGTNNARLAQLLRQLASYYHRDQDALFMVRIAQGLLHMGKGTLSISPFHTDRQVLSRVAAAGLLATLVAMIEPKEFITGQSHYLLYFLVTAMHPRFLVTLDEDLKPLKVNVRVGQAVDVVGQAGRPKTITGWQTQSTPVVLGYGERAELEDEEYISLNSTLEGLVILRKNPDWEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUY0</accession>
    <name>S0DUY0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_03279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428347.1">
        <property type="nucleotide sequence ID" value="XM_023575109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUY0"/>
    <dbReference type="STRING" id="1279085.S0DUY0"/>
    <dbReference type="GeneID" id="35396761"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03279"/>
    <dbReference type="HOGENOM" id="CLU_117700_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000173">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT66266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="137" mass="15135" checksum="0532FE2B849C5511" modified="2013-09-18" version="1">MTVKAIRQIAKGQNGLGAFILQCKKLDFYYCDWAGSSKGMNGFIKSLLPKFAAANPQVEFSISPRPGKHPVVVGHYINGRTKPICVRNLSPYEILQKAELLRDASGEKLKRYNKAVNSAQPSVRGVWSPYHGKGMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV61</accession>
    <name>S0DV61_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_02215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427363.1">
        <property type="nucleotide sequence ID" value="XM_023573920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV61"/>
    <dbReference type="STRING" id="1279085.S0DV61"/>
    <dbReference type="GeneID" id="35395697"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02215"/>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="7">
        <location>
            <begin position="430"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT65282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="594" mass="65807" checksum="F9A72853E4B9A709" modified="2013-09-18" version="1">MAFVANGNEYDFIIVGGGTAGNTVAGRLAENPHVRILIVEAGIPNPHQIPEITTPSKAFNLRGSKHDWAYKSTMIKRDDYERIEKPNTRGKVLGGSSCANYFTWIPGSKPTFDDWEAFGGEDWNWDGCVEYLRKCATYHDEEGLYPAELGKIGTGGPIQIAHADLVPEMQPWRDALTEAWVSKGEVLTENIYDGEMRGLTHCVDTIHGGQRQGSFLYLKNKPNVNILYGVQSKELIIDPRTNTCLGVTVINPDTKGELSVFASKEVILSQGVFETPKLLMLSGVGPAQELQKNGINVKLESPHVGQHLLDHPIVPFVLQVKDGFGLENYILRNGAANSAAVAQYKRDKTGPVSSGLLELVGFPRIDERLEQHQSYREAKAANGGLDPFGPKGQPHFELDFVGMFSTAFQWHYPVPEKGNYMTVIVDLLRPLSEGQVTLNSNNPLVQPNINLNFFGNDLDILAMREGVRWTYDVLTTGKGFKDIVTGEYPWRMPLESDEEMKRAVLDRSQTGFHPCGTARLSKNIQQGVVDSRLRVHGIKNLRIADASVIPVIPDCRIQNSVYMIGEKGADMIKADHPEIFGQAPIRANPFTSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVC8</accession>
    <name>S0DVC8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426529.1">
        <property type="nucleotide sequence ID" value="XM_023572399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVC8"/>
    <dbReference type="STRING" id="1279085.S0DVC8"/>
    <dbReference type="GeneID" id="35397809"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04328"/>
    <dbReference type="HOGENOM" id="CLU_457112_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="597" mass="66078" checksum="46C1CDF6D1AC1DAF" modified="2013-09-18" version="1">MEHLNGPAILSGLLMSSVVYWHVYYLADYLLRKYAPTVHERLKNEDQIRKLMPLVITLVRMAFGLTVVLPSCIQAASTTPWGVDRPLNNAGKVCVVSQLAVWSNELPQARLYSMELFVHHILCLVATANIILSPPIHQIKPLYIYFGSQCGDIGPGSVMILRMAGHKLKTSKLLYNVSLGSTLLLIFGRIGGAFYTLTHVLTDPYNLADWVGALGILVFGSYSTYTAFQHLRRLEIIKVDPVRYKITYFRHFAVPISHSLLAVACSVTLLSSLFLYGIYLERPLKPGETHGLSLHSLIAVALGMTGALVARLAYPHNASRSNSWGRLYVPFGTILTVACISLNSTFTSYTDHNTVMASIGVSLPLFFSLARVAQYYAAKDVEVVRDAKLPPGDSFIRRHVEIALEHAVIFIILLGILIINLLSLPEAARLSIAACLVVQLRYRWSIVPLAATNIHGLVGALLAIVLIVFEPGFIAFATAGRFIRLESSWSAIFQNYLLLGGTVMAAISAPRSETASRPCETMKKPCRSKRFHPIAIIFVFFCILQAMLIAKYMTFDGETSEICPGFVNFRSIFSDVYTWVGVLHMASLPVVVLRELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVD7</accession>
    <name>S0DVD7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_04318</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426539.1">
        <property type="nucleotide sequence ID" value="XM_023572411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVD7"/>
    <dbReference type="STRING" id="1279085.S0DVD7"/>
    <dbReference type="GeneID" id="35397799"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04318"/>
    <dbReference type="HOGENOM" id="CLU_045637_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT64458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="305" mass="34327" checksum="5FFB9ACEE625A973" modified="2013-09-18" version="1">MSALTEITLPSFQKIASGKVRDLFELPDKNTLLFVASDRVSAYDAVLKNPIPDKGKILTLVSAHWFQVLTERIPGLRTHFISLDIPEGVTPEEAKTIKDRSMVVKKLSVIKIESIVRGYLTGSAFKEYKQKGTVHGITVEPGMEEAQKFKQPLWTPSTKADAGEHDENIHPDDAWKEVGDRETADRVKELSLKIYEEAAKYAEERGILLADTKFEFAKDGEGNIYLVDEVLTPDSSRFWPAAGYMPGRDQDSFDKQFIRNWLTKEGLKGKEGVELPQDIVQATADRYREAFLMLTGKKFDDAVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVS7</accession>
    <name>S0DVS7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to TOK1-voltage-gated, outward-rectifying K+ channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04177</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426669.1">
        <property type="nucleotide sequence ID" value="XM_023572569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVS7"/>
    <dbReference type="STRING" id="1279085.S0DVS7"/>
    <dbReference type="GeneID" id="35397658"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04177"/>
    <dbReference type="HOGENOM" id="CLU_013394_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000170">
        <property type="entry name" value="Outward-rectifier potassium channel TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000182">
        <property type="entry name" value="Outward-rectifier potassium channel TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="212"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="379"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="628"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="703"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT64588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="741" mass="84367" checksum="25C6EA9277CFD8C9" modified="2013-09-18" version="1">MDDGDLGDNIQQETDIIEESVSHDRRIGNDDAHLAPNRWWFASSAFPMIAGTLGPVASAFSICALVRPWRQHYIPKQPLKEADFVADPIWLTVINAIQLGMAIISNIFLLLNMTRRVRFTIAQPLTIIGWYISAILLIALLATASGPLYEGFGHPKNELIWSQAFYYGIWAAILYFVDASLMVITFYGASVGHYPNDFNLTPSQRTLMLQTIMFLLYLLVGAVVFSNIENWNYLDTVYWADVTLFTVGFGDFTAQTNLGRALMMPYALVGVISLGLVIGSIRSLVLERGKKQVDARMEEKKRRRIVRTMTKKGQDEVLEPIREPRQQDSIGSQSAQSNNQLPATEYERRKAEFDLMRKIQAQTSYRRRWVAMGISTGVWLILWLLGAYIFVKCEEDYQGWKYFDGFYFCFVSLTTIGYGDVTPISNAGKSFFVFWSLLALPTMTVLISNAGDTVVKLIRDGTLRLGNVTILPGEDNFKSDLKYIINRCTFGLMYANYTEPPPLNREKKPASKNSSTDTSDSTTKKEEDKLDEYARGRPRRSETGEDDDPADPRPGQDRNNSTFTARVRRSLSRLRDAHEELPTGTNLHFLLISEIQVLMNHLKSSKPHKYSFEQWAWYLKLIGEDESNAETHGKAQPSSRHHHHNHPRRKKTNETAEGVEKDVVSDDTTAWSWVGNRSPLMGSQEETEWILDRLLERLRESLSVEGKKQVTADARRALGADRRRSPDDTYHRKKDGRKEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVU9</accession>
    <name>S0DVU9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428702.1">
        <property type="nucleotide sequence ID" value="XM_023575535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVU9"/>
    <dbReference type="STRING" id="1279085.S0DVU9"/>
    <dbReference type="GeneID" id="35397144"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03663"/>
    <dbReference type="HOGENOM" id="CLU_672758_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="415" mass="45674" checksum="922E623F26E7816B" modified="2013-09-18" version="1">MVPPKLRGCCDSCTKSKLKCSGEMSCCQRCRIRGLDCVYSKARRAGRPRLKPKPSQASITSCINREPQTNLITFIGQSVNDQPCPEPELPVCPNPGILLYSPDTQDIAYLMQDPWTSTPCPSSDVTRPSSVCHFDDLMLQDMMLNNNESFGLVSPRGLKQERGQDSALFSDGLDDTCPGHGITNVGPSSHTPSSLSEFYKHTIRDIEDSNGHLSEVDMEINAIMAIITDIAKRPIATYHLDDHPCASSWPQLLSKAQLLMYIAGSANSSSPRLDAVLQISWAAEQVQERISGCPACKPRSMELFSMVALLYDWISSQIADALENPAALQICRLRIGNSVLTGQNGLIGTYELVKYRITRAIHVIENINNTNATVMEGDPGQLYKMTQLMLEVAESRLEAISGLIDLLESEQFCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWN3</accession>
    <name>S0DWN3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_13140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429045.1">
        <property type="nucleotide sequence ID" value="XM_023575789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWN3"/>
    <dbReference type="STRING" id="1279085.S0DWN3"/>
    <dbReference type="GeneID" id="35406594"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13140"/>
    <dbReference type="HOGENOM" id="CLU_009074_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="10">
        <location>
            <begin position="108"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="9">
        <location>
            <begin position="396"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT66964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="779" mass="88551" checksum="556476FC66D0A8C6" modified="2013-09-18" version="1">MVANSTGLEGSALKSRKRAADSELEPLLKQGQPFPKQPRISSHLDTTRWRLKDDDSRHTWHYLENDDDAKEWPQSYAEKWYLNLPLDLPDLPTPDNPLAAAENGLDFFEKLQLPSGHWGCEYGGPMFLLPGIVMTWYVTRTPVSSAKATAIYNYISARAHPEDGGWGLHIEGESSVFGTLMNYVALRLLGVDPEDPVLVKARGTLHTMGGALYAPHWAKFWMAVLGLMSWDIVNPVPPEFWLLPDWVPFAPWRWWIHIRMVFLPMGWLYSKRWSCEETDVIRSLKKEVFLEDYAKINWSSHRNSIGAIDNYHPKSCFLNAANWKAEAWASKQVDMEDANTGYACLAPVNAAMNTVMCYARDGPDNYGVKRHIERLEEYLWVKDEGMLANGTNGVQCWDTAFLIQAVFEAGLHKNEKYRPMLMKSLHYLERQQIREDCVDQEVCYRQPRKGGWPFSNRDQGYGVSDCISEALKAIILLQKVGGLPEVLEDRRLFDAVDTLLLYQNDNGGMSSYEKRRGGEWLEMLNAAEVFGRIMIEYDYPECTTACVTALSMFNKHWPDYRTDEVRTLIRTAAEWIKSNQAPDGSWYGSWGICFTYAGMFALESMKHIGQTYATGENSRRGCDFFISKQRADGGWSESYKACETMTYIEHPSGSLVVQTAWALIGLMEAEYPHVEPLRRGIQFIMDRQKPNGEWLQEAIEGVFNKSCMISYPNYKFTFTIKALGMFAKRFPEEKLVPSWAVAENGTNGVKTNGVKTVEIKVNGAKPNGVKTNGVKGKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWP9</accession>
    <name>S0DWP9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_02804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427908.1">
        <property type="nucleotide sequence ID" value="XM_023574579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWP9"/>
    <dbReference type="STRING" id="1279085.S0DWP9"/>
    <dbReference type="GeneID" id="35396286"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02804"/>
    <dbReference type="HOGENOM" id="CLU_021795_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="228"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="346"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="455"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT65827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="554" mass="62238" checksum="9723E097327FD935" modified="2013-09-18" version="1">MNGDSYSSRDGRRGRDYPPRGERGDRDDRRDRHRDRDRRRSRSPEHRSHRRGEGDVDAYSSSRNHRDREREDRYSGRERRGGDREWDRDRGSSRRDARRDDDERPNRRDRDPYEDRRRGGRDRREDRFPAQQERRSASPPPKKREPTPDLTNIVPVLDRKRRLTQWDIKPPGYENVTAEQAKLSGMFPLPGAPRQQPMDPSKLQAFMNQPGGQVTSAGLKANNSRQSKRLLVSRIPSGTSEEALMSFFNLQLNGLNVIDTTDPCVLCQFSNDRSFAVIEFKDAPEATVALAMDGISMEASDASNGTDGGHRGLEIRRPRDYVVPAVTEEVSYNSEVVSNIVPDTVNKLSITNIPTFLTEEQIIELLASFGKPKAFALVKDRGTEESRGIAFAEYQDPAASNPTALDTLNGMEIGGKKLKVSKASIGPTQVANFDVGITAISGLASQTANEVESSRVLQLLNMVTAEELLDNDDYEEICEDVREECSKFGKIIDVKVPRPTGGSRQSAGVGKIFVKYERAEDTAKALQALAGRKFADRTVVTTYFPEENFDVGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZB2</accession>
    <name>S0DZB2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">FFUJ_02794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZB2"/>
    <dbReference type="STRING" id="1279085.S0DZB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02794"/>
    <dbReference type="HOGENOM" id="CLU_095765_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000093">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT65818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="180" mass="20340" checksum="1D3CD2A1D6A07DB4" modified="2013-09-18" version="1">MLGPPVNLPRWLEENSHLLQPPINNYCVYNEDFSVMIVGGPNARTDYHINQTPEWFYQYKGAMMLKVVDEGEFRDIIIREGDMFLLPGNTPHNPVRFANTVGVVLEQRRPKDSLDRMRWYCGDCGEIVHEAAFHCTDLGTQIKAAVQDFKSSEDKRACPKCGTMAEAAPKPGTIQDPNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZP6</accession>
    <name>S0DZP6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">succinate-semialdehyde dehydrogenase [NAD(P)(+)]</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_06794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430119.1">
        <property type="nucleotide sequence ID" value="XM_023576974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZP6"/>
    <dbReference type="STRING" id="1279085.S0DZP6"/>
    <dbReference type="GeneID" id="35400271"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06794"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="93"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT68039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="563" mass="61246" checksum="5D1EEFD169022A6F" modified="2013-09-18" version="1">MALSKVDSAAFVNSRYTHPELDSLPNWTLVSYVPVMLQRGVKADLAMVPVTESHFASFIPPYIIMGSSHHLPFSLTDDSLFRPKSLINGEFLSSKEGKTFNVIDPGTGLTWASCPDCTASDVDAAVKSSYEAFKSYSKTTPRFRAQTIMKWYNLMVAAREDLAHILVHETGKPLEEARGEIDYALTFVWWFSGEADRAHGSSITCAIPGRRAMTIKQPIGVAAALVPWNFPIALALRKAAAALAAGCTMVIKPSPETPLTAVSVAYLALKAGFPPGALNVVTTSLENTPAVAEALCLNPLVKKVSFTGSTRVGKIIASLCAQNLKKTTFELGGNCPFIVFDDANVDQAMNQLMALKWRHAGQACVTSNRVFVQSNIYDSFVERLVSETRTLKLGHGMMEGVTLGALTTTRGLEKAEELYEDAVSKGAKAVLGTGKRYEGEGYFMEPTILTEMNDEMLMTHEEIFAPLLGVYRFESEEEVVQRANDTPYGLASYVFTKNVDRLWRMFENLDAGMIGLNAGNSSSAEAPFGGIKDSGHGKESGKDVAIDEFLITKTGTMTVEGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZP8</accession>
    <name>S0DZP8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to cytochrome p450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_06763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430091.1">
        <property type="nucleotide sequence ID" value="XM_023576940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZP8"/>
    <dbReference type="STRING" id="1279085.S0DZP8"/>
    <dbReference type="GeneID" id="35400240"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06763"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF8">
        <property type="entry name" value="CYTOCHROME P450 2E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485122" evidence="7">
        <location>
            <begin position="19"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT68011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="518" mass="59086" checksum="39789D306860733D" modified="2013-09-18" version="1">MLFVWIAAIIAIAWLVLGPSSNTKGSGKPLPGPPGKPLVGNLFEIPQYHSWLKFKDWADTYGPIFRLNLAGRQHVVLSTEKIANDLLRERGSYYSSREFLPMASGIVSREMRPLLLPYNDLWRRGRKLMHQLTMPAAADSYQAVQDYESKKLLVSLLETPANYDKWFELYASGVVFRIGFGKWIETGDEPAVKRIIQVVHNLERVASPGAYLVDSMPFLNSLPEAVAPFKREGRRLHEEELSLFRELQYDVGRALKKGSDTQCFTRTFLENKAGYQLSDDEGAYVIGTLFEAGSGTTAAAMMSYCLAMCHFPEWQRKMQDELDEQVGDRMPEFEDIPKLPTVRAVIKEVLRWRPVTAGGFPHQLTKDDEYEGFSFKKGTIFHPNQWAIHRDPALYPDPDNFRPDRWLDPKFPTTYKEPLSKFPNLQNYSCFGFGRRICPGQNIAERSLHILTARVAWAGSVVKKRDANGAELPVPLYDYAIGFNTQPEHFDFDVVPRSQARHTVIKEYLKEARSKRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZR4</accession>
    <name>S0DZR4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428983.1">
        <property type="nucleotide sequence ID" value="XM_023575712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZR4"/>
    <dbReference type="STRING" id="1279085.S0DZR4"/>
    <dbReference type="GeneID" id="35406526"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13070"/>
    <dbReference type="HOGENOM" id="CLU_025883_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT66902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="501" mass="57358" checksum="D88E580E821E1EEA" modified="2013-09-18" version="1">MDPHKTIVAGVADRVKHFHARQEPFRLYHGSTNSTRHSNRRVDNTVDTSKLNHVIEVNKDSKTAIVEPNVSMEVLVDATLPLGLVPLVVMEFPAITVGGGFSGTSGESSSFRYGAFDATVNWIEIVLADGSVTRASKTEQPDLFWGTASAFGTLGVVTLLEVQLKEAKEYVELKYRLARGPSESVKIIKEECKRWENDYVDGIAYSKDTTVVCAGRMVDEIPISATPRQLNRRRDKWFYLHVEKVRDGLRMGSVTCVADYIPLKDYLFRYDRGGFWVAKYAFDYFLTPFNRLTRYILDPLLRARVMYSAGHKSNLFDYYMVQDVGVPYNSVPEFQNWLDKQFRIYPLWICPLRVRREDPDSGYGLHAEFAKPGTVELMNFGIWGPLQGNRRDAIRHNRALEQKVQDCGGKKWLYAQAYYTEDEFWSHYNKEAYDALRAKYGASYLPNVYDKVKVDIEGDEKLMKSTARTGWPIRGLRGVYKAVFGGDYLLQKKKDEPSEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E101</accession>
    <name>S0E101_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like protein AAED1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430430.1">
        <property type="nucleotide sequence ID" value="XM_023577345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E101"/>
    <dbReference type="STRING" id="1279085.S0E101"/>
    <dbReference type="GeneID" id="35400604"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07127"/>
    <dbReference type="HOGENOM" id="CLU_035338_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000404">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="40983" checksum="670481CCAE48D6BB" modified="2013-09-18" version="1">MTDNHTEANASNTTKSPIERKPVGGIPPESPSVERAPTLPPRPAQDSDEKTSEAPKCDTCSVPKKAGSTRSKSPPTPIEVDKTQPEDFEGELATNNDLPSAETLKKIENYIVLDRHGKSHPFKTLYTGSNVARRVLIIFVRHFFCGNCQEFLRSLSDAITPEALLRLPVSTFIAVIGCGDPALIDMYVNETGCRFPVYTDPTRSLFDALGMSKTLQLGTKPAYMRRSMMHSIVGSIVQGVKQIPTGNVLKMGDQRQVGGEFLFEPRDILTPVSTPRDEKAKPISAFEEAEERGPDHDGNEEKRVTWCHRMKTTRDHAEIPELIEVLGLDQTATAGRDVSRGSITSARKGKGHSMAQEIRKLSAERSRTSNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1N8</accession>
    <name>S0E1N8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_07410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430690.1">
        <property type="nucleotide sequence ID" value="XM_023577658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1N8"/>
    <dbReference type="STRING" id="1279085.S0E1N8"/>
    <dbReference type="GeneID" id="35400887"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07410"/>
    <dbReference type="HOGENOM" id="CLU_055657_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="94"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT68610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="312" mass="34187" checksum="A05CBFD5C53CB4E1" modified="2013-09-18" version="1">MTRLILSTANVMLAGPSIIRKPGNSRSNLELVNSLRDNIAEAQRDYAIDAQETNGFTNGDTAKGKHTVVDLWTEQEGDALYVPRINWNAAGLQEEPSQYEITVKFFVLPGMSVAAGEQHVKEALDLVRRELGIQTIDLLIVSFPGISFEGNCEWEADKTNAQQGNLEEELATWKVFEGLHKQGLVKRLAVAEFGSEKLGAFIKRASVRPVIDQINLRNCCDVPPPLKKLADQEGVELHVHNDCIDILPHGTLRELLSHGPKSAGLLADPGNSGKGLTGEIVPEWVVRYTAFVQDRGVIENKGYFAGAELVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1R9</accession>
    <name>S0E1R9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430720.1">
        <property type="nucleotide sequence ID" value="XM_023577694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1R9"/>
    <dbReference type="STRING" id="1279085.S0E1R9"/>
    <dbReference type="GeneID" id="35400919"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07442"/>
    <dbReference type="HOGENOM" id="CLU_010112_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="3">
        <location>
            <begin position="177"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="673" mass="72491" checksum="4A8DF072AB301A8D" modified="2013-09-18" version="1">MSDYGIQLIRDSISEEPGSATTTRPPTSRTRGFTTSSGRQTVRWPFHSFSNSRSSIPNYPRRPSNSRSIPHSSGSFPRRAAGSISRSVSSVLGSDIIPDYVVNFMRGETPETLARRHRIPDSPEPGQFQRPQESQLDFIHSASSTPDNSRPGTPRAEREKMLVEERPQPTRSLMTGWRAGVAANMFLAFLILVASVACLALASAQGHMSTWESLLMEGSSTTVEGIARGILAAVNVFAIILIAGANYVVQILNSPTRAEVENAHSTFKWLDIGIPSLRNMSLISSTRATLSGIMMVFALLSQVIYNSIIITTEHAENSKSSLNVNGPLLAAITLINVVLILTYAIAVALALTRQVFSPLVTLGDALSSFLADPDVSTHNSCLITKEEIKKGLWGDREGKYWYAKTSRWFNVPSFNRWAIWFMTWIMPVGLAAAALALGAVKEPKEAFTRFGKAPVVYELPAGTSRSGMAVVVALPQLLLGLLYLSSNALLTLFYLSHELSQFTSDLLPLRVSSGQPLGSQTTSLYLTLPRPVSWILFFLVTAMAFLLSQGILLVSVDGIKGTTTGIGFSPLPLLILLVLLVLLGLGIAGLALRQVDPRGSVEGGEPAGNPLALVGGTCSAVLSARCHRVAREGGVETLEVRWGVVREGVGMNAGHATFSGRPVGDIMVGRAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E267</accession>
    <name>S0E267_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_07706</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430961.1">
        <property type="nucleotide sequence ID" value="XM_023577988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E267"/>
    <dbReference type="STRING" id="1279085.S0E267"/>
    <dbReference type="GeneID" id="35401183"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07706"/>
    <dbReference type="HOGENOM" id="CLU_023334_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT68881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="401" mass="44003" checksum="699CBC2AC061DC02" modified="2013-09-18" version="1">MKLVARNKALNAYAEEAVSLLPEDPEDMWHAYNLILSGDIVHAHTIRKVTVTTDTGSSKSERHHTNLTIKVKSTTFDPIISSLRVSGSVVIENNLAPLGSHHTLDLEVNRPFSIVKLDGWDSVARATLQEALSDDKDGAVAAVVMQEGLANICLITPFRTVLKVRVESVIPKKRDLASDQDAGMRRFFEKTLSTLLRTMDFTESRPLLLASPGFVAGDFKQYIANQGRDKADKVLTAVAKQATVVHSNSGHVHSLNEILKSPEVLAKMKDMKFARETQYVDQFFEMLKLDDGRAWYGTSAVEKAVKEGAVGPGGGVLLVNNSLFRSEDLALRKKYVALVDKVRSDGGEARVLSSDHESGQRLTMLGDIAAILNYPMLDLDEDDAEKDNEATGESTIENSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2H1</accession>
    <name>S0E2H1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429938.1">
        <property type="nucleotide sequence ID" value="XM_023576563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2H1"/>
    <dbReference type="STRING" id="1279085.S0E2H1"/>
    <dbReference type="GeneID" id="35407990"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14609"/>
    <dbReference type="HOGENOM" id="CLU_036728_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="494" mass="55905" checksum="F9823DB57C8972C6" modified="2013-09-18" version="1">MPLYAPDPQVNELSLICSRGIGRGDPDSLDQALSSGVNPNDPPPQSERHGEQLQPPLYCAADMMCHDPEYMKEGLQMIHSLLSYGSDPYQEFPQALYCPDRSSKPRAPFPSEDPPSTPFPEVLIGFKSLEEREKWERENDDQHPHFSDDEWENEETAPVWGVRHMIHAIIEDDGLLKPFIDYPGFLESLDLEHRDPQGRTLLLSACRSAVGADVLAGTGFNEVHWKVENTSPTSKIYPSWDRNAGPTESDFSEPGMESLVEMLLRLGANPLAVDYQGKNALHHLLVEVCNNNTGRFHRLPVVRRSLRIFASGYPSLVNQPDQHGAYPLHAALCRMRLYPDFNYYTRVKLGEPLCCVQDMLRMGVDRRAKDGKGNTALHYLADDDLTGVYPSEDFRNWQEVDREVFTTLDDAGIDWKAKTSEGGNLLHLVARSGLSQERLIWRSRFLVDKGIDPTALDADGWTAKKIAEHYRLNKLLFYEELGKLEKGEDKVECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2M9</accession>
    <name>S0E2M9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429997.1">
        <property type="nucleotide sequence ID" value="XM_023576829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2M9"/>
    <dbReference type="STRING" id="1279085.S0E2M9"/>
    <dbReference type="GeneID" id="35408218"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14840"/>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="383" mass="43137" checksum="2279D549B259A43E" modified="2013-09-18" version="1">MSDTQASNKTIDEPVPTTDVSSQDEAPTGLLPGQHWTQTEPDQDDDDNDSTLSDNASSTASLSSDILRYREINGRRYHSEQGDAQYWSVVISAVMGHGHQVWHVEFNFLSRISNDNQANEALDINHHVLILMYNDKLFKAPLNDNVQNVVDIGTGTGIWAMDFADEFPNAKVIGTDISPIQPGWLPPNLEFQIDDCMQEWTFKENSLDYVHMRFLVGSIIDWPGLFKQAYKCLKPGGYIESHEASPCIGSDDNSVSEDSAMGQWGKIFMEGGRKLQRPFSVLEDNVQVESMNEAGFINIEEEEIKVPIGGWPEDPRLKEAGQYFHAAILQDVEGTLTFIANLLGWSKEEIHVFAARYRREIRSKKVHGYFRGKVVWAQKPLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2Z3</accession>
    <name>S0E2Z3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430092.1">
        <property type="nucleotide sequence ID" value="XM_023576942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2Z3"/>
    <dbReference type="STRING" id="1279085.S0E2Z3"/>
    <dbReference type="GeneID" id="35400242"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06765"/>
    <dbReference type="HOGENOM" id="CLU_017513_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF37">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="287"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="655" mass="75082" checksum="2899E3BCD23E15AD" modified="2013-09-18" version="1">MGSAASWRVPTSIPQAPDHLSIRIQKPLDAAWKLPTIEFTRSDSDKRTRPIDESSSQRTQFVASDADDVTSVSDWGLAAATNHFNDSHFHNLDYLKLIEKLGGWDEVHHQLWLRNLAGIPFIMSIQWRIEGSLQRNCTDGEEYLPIDAFESIFTPECILLLVLDAFHGVAITQVIRILDHILGKRTGPSRRRLFGILTFMNRRKYLVNFIRAGIYDSNLPLKPSTKSQRSFESQKTNTINTSLFKGWARTDVDLFYIYQKMFCIPFFDFQHNSLCFYALAADVRLPWQVLEHKFTGGSGTVYKLQIHPGHHNFRSGSQDSHEMTFFALKKIDWIDRQAYREELRALQRSRAQITQDKHLIRLLLALQHGERLYLLFEWADGNLLNLWEEVPHKDPSGSTIQRWAANQCFGVANAVRRIHGLTTGQIQRRSSSASDVTDKIKEWGRHGDIKPSNILWFKKYKGDDNVLVISDLGLTRYHSFHTKSLVPRIDGYTSAYAAPELELNQPISQKYDIWSLGCVFLEFCIWYVKGNNAVMEFESELADQHESDISNFAHDNYFIIKTEKDGKKSAQLKPAVTTWIADLRDSPRGSDFVLKMLELIQDRMLVVDVDKRWSISLVCREISGIRSSLPKLEHTEDLLLGIGVGAEQALDRVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E324</accession>
    <name>S0E324_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68027.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="353" mass="37342" checksum="89A742BE16AC2B64" modified="2013-09-18" version="1">MSSTTENLNRSAVLPHPKAHPIVITSSPVPIPTGNEILIRVRAVAINPADHAVQKLGIVIKPEFYPYVNGTDMSGEVVSVGSDQARFKPGDRVVGHAMAWQKGDNKYGAFQDYSIMVEPMVAKIPDHIPFKDAAVLPLGLTTSAAMLFSPTLMRLDLPMAGTELNSKGKVVVVWGGSSSVGSNAIQTVKAAGYIVAATASEHNHGLLRKMNVDYVFDYKKDGVTEEIINTLSGVGDLAGVYCAVYSDTAITACATIANRLGGKKCLGTILPPGMPVPGTIPDGVQVLINDHVLLGSTETGKRLWVDWLPGALEDGTMKCMPHPEVVGKGLEKIQDAVDAIGKGVSGKKLVVEL</sequence>
</entry>
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            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
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                <person name="Guldener U."/>
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            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07652"/>
    <dbReference type="HOGENOM" id="CLU_690877_0_0_1"/>
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        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="245"/>
            <end position="321"/>
        </location>
    </feature>
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            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
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        <location>
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            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46572" checksum="E718F70FB194C6A7" modified="2013-09-18" version="1">MPASSQQPMAPPARSEEEISTASESEAEEEIEVPSSQPAPSQSLPARRPTARQNASKRATRRAPRSDIQNPGSKARWTRDQMEYLLESYGAKRVAGELENEKTQLLKTIHAKIGCELAERYPPNVFDQTKVGRKLGELLRNWKAFLAIMRETSGAGYDHELGIVTTTDDNWDRWVKKHGIGAAAIKRNGLQKMDLYQRAFDGVQEVGLTALEVTDTSGLLSLRNDMEESQIDSQIDEDLVFHSQPSAHEAAQRHLPSRPSPSPFREVTATPAPSSSQTSQLTSSPSGRPSHPTTSSSGDSQSPQRVRRPHRHVDPQAGSIEKAVSKLVTSREKSRRPIGADDTQSAVQDVQQRFLERADEGEIETFFDWLLGDSMRAVFYNSLNERMKERLFCSKSGCIVLRSPQIDLEMTQDSEFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4G5</accession>
    <name>S0E4G5_GIBF5</name>
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        <submittedName>
            <fullName evidence="8">Related to Polyamine transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_07356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF76">
        <property type="entry name" value="POLYAMINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="710"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="881"/>
            <end position="904"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1077"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1090"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT68567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1100" mass="121408" checksum="BDD0AD34B5C3D28E" modified="2013-09-18" version="1">MSTDEGWKKTGMNCPGGSASKDKSIASPEKYAVFTNASSVGNQDARRFSSLSTGTCLHNMPSSDTQLHGSYVQNNSSHDTNCPELSLMEDQSLLATNMNRPVRSQSSGSIMSCLWKSQWLKRLSRTAKSDGSQLTKPQPGIKLIRSDDRRPSEPVLPSSMALRRMSACSTLSGKSGPGVDGVLFKRAFSDLERLLDEALSLALDVADHSEAAAHASHPAASKEHGADRVDESNMSMGDRPQENVETIPIDGSDMAYPARPGCRRAATYTAVPKRPRLADVVESYSGTYQELRTRTQAARRQQSGTSRRSSLSRKSRKSNKGFKTDRRLRPSMLNDLRSTTALLDIGGMDVKEQTTARKRSAAVEASSAVRSGTSHDALPEHNIAGRRLHGEHGINLRKRSHSPVRKRFVASTACLSTALIGVLLGIYTGLVPSIQYYIVDQSHVTVHGNTGCFLALAIPSFFLWPLPLLHGRKPYIMSSLIIAMPLLFPQAIAVSSPRLTNTASWRVMLLASRTLMGGSLGFATMNFHSVLTDLFGASLMCQHPHEEVVDHFDARRHGGGMGIWLGIWTWCWIGSLGLGFLIGAAIIDKHSPAWGFYISIMMIAVVLILNVICPEVRRSAFRRSIAEVRTGGDISHRLARGEVMMHRVKTGPKWWGQEAYHGVRLSLEMLEQPGFAVVAIYVAWIYAQVVLVIILLGSLVSRFYHLRSPYVGLHVAAVALGALLAIPFQKASIFSRSRNRENKVNREVLGKKIVWSSHLVRRAVFTIALPIGGACYAAVSSGPPISSGVPTFFALCIGFLSSLAISECNGLIMETFDTSDLSPGMVGRHRDPTGQDQRRTNYSSFPRVTAGFAMIQSFSYILAAGSTALGGHVTRKLGQQVATSVVAAILFLLTVLLLLVLIRFKNVLIIPRSKSEEMERITQARRRSSKRRASMPNDLRALMEEDYAWRPTMIGNPMGKNRRMNVLEMGNLTRWQDIRRRNKLIDAGVHLNRDTLDQGLDALDVALENHIDDMRQNASGFFRRGSLRKHGRRLRRSNQSSEQAFHDLELDMLDPVGTPSESSQQPRQYVERECVMGQTIKEENKDETQAGPSTLQRDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4H0</accession>
    <name>S0E4H0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to monocarboxylate transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_05428</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431615.1">
        <property type="nucleotide sequence ID" value="XM_023578637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4H0"/>
    <dbReference type="GeneID" id="35398907"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05428"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="55"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT69535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="450" mass="48177" checksum="A8EB2657E5BAF251" modified="2013-09-18" version="1">MAQTKTSLSSATRPDMNLETSEKHPHVEGLPEALPESQTVSPISETEYPEGGQEAWLVVIGGWFGLFCTFGLVTCVGVFLEYYQTGPLADYSPSSISWITSLQVFFQVGGSAVWGRVYDSYGPRYLLLIGAPVYVFGIMMLSLSTQYYQILLSQALLSSMGSGAVFTASLTSTTSWFRKKRGTVFGIVNSGSSAGGIVLPIMLSRLFKIIGFGWTLRAVGFMFLAFMAISCVLIRSRTPSKPRPFALSDYQRCLKEPVMVLTMFGGFLFFWGMFLPLNYIIIQAKASGVSSDLVPYLLPLINGISLIGRLTAGALADVIGQFNCMLIITTFTGILTLVLWIPGSQSTAAIMAYAVAFGYGSGGYVSIFPGCVGQISPIEEIGTRIGLASLVNAFGALTGSPLGGALISDKSGSGNSFMGLQLFCGCAMIASVLAYGTARYCQAGFRRTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4L5</accession>
    <name>S0E4L5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to calcium-binding protein caleosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431665.1">
        <property type="nucleotide sequence ID" value="XM_023578698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4L5"/>
    <dbReference type="STRING" id="1279085.S0E4L5"/>
    <dbReference type="GeneID" id="35398961"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05482"/>
    <dbReference type="HOGENOM" id="CLU_062049_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF0">
        <property type="entry name" value="BINDING PROTEIN CALEOSIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="253" mass="28872" checksum="07254AA66737B55C" modified="2013-09-18" version="1">MDFDDPKNTKSYSDALKVDPNSIITTSIDAVPVTVERKPYQPGVDKPRLAHAGVARANLAATHERPEGTTENDWAQRHQDQTVLQQHCDFFDKDHDGVIWPIDTFRGFYQLGYGIILSVISVLVIHGNFSYPTQSSLLPDPFFRIHIDNIHKDKHGSDTGTYDTEGRFIPQKFEDIFSKYAEGRDYLTIWDVSNLMKGQRLIADPIGWGGAFFEWLATYILLWPDDGRMMKEDIRGIYDGSLFYKVAARRAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0E535</accession>
    <name>S0E535_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_05919</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432068.1">
        <property type="nucleotide sequence ID" value="XM_023579185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E535"/>
    <dbReference type="STRING" id="1279085.S0E535"/>
    <dbReference type="GeneID" id="35399397"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05919"/>
    <dbReference type="HOGENOM" id="CLU_038194_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="44"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="241"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT69989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="333" mass="36773" checksum="2A322790DE93957A" modified="2013-09-18" version="1">MASTKGLTRTTFAKLSPHPYLLASLDPASDDIRPARSNGRARNESRKPTVNLASLSHAHGSAVVRVGDTTVICGVRGETILTPNIPNYRASNTETELKDYDLLVPNIELATGCAPQFLPGGPPSTLAQTLSTRIYSLLHSSRIIKPDDLRIWHTPLSEDLEDHMEEDGEDTSNENRSVVAYWVLYIDIFFISFDGNPFDAAWAATMAALRNTKLPGARYDIDREMVICSHKQARPLNITNIPIACTAVVFTGKETDRPTDGRFWLLVDPDRLEESLCDESVTVVVDCKDGDLKLLSISKHGGTALTPQFLTSEQFLGWASKRWEEFNAAITQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0E561</accession>
    <name>S0E561_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_05947</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432093.1">
        <property type="nucleotide sequence ID" value="XM_023579215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E561"/>
    <dbReference type="STRING" id="1279085.S0E561"/>
    <dbReference type="GeneID" id="35399425"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05947"/>
    <dbReference type="HOGENOM" id="CLU_071681_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1340:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="119"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT70014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="172" mass="19386" checksum="B53671F9C942919D" modified="2013-09-18" version="1">MATGDSQDIPMGSPPEPPAEVDREPKYGGYSRFEVELEFVQSLANPAYLNHLASQKLLSQPAFVAYLGYLQYWSKPPYLKYLTYPGPTLRHLELLQQETFRQQIISPDVVRALMEEGMKASDDTKGTSNNKRNQDEAVNESMPDTPRKRKTPRKKKKHSAIKDSATPVGTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E594</accession>
    <name>S0E594_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to WD repeat-containing protein 44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_07707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430962.1">
        <property type="nucleotide sequence ID" value="XM_023577989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E594"/>
    <dbReference type="STRING" id="1279085.S0E594"/>
    <dbReference type="GeneID" id="35401184"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07707"/>
    <dbReference type="HOGENOM" id="CLU_004759_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="328"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="368"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="523"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="598"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="851"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="736"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="776"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="852"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="949"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT68882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="960" mass="105213" checksum="5ADF5AD604010AA7" modified="2013-09-18" version="1">MSASKSSPAVRGERGLYRRRDSALSSLPESEPQRRQSLAARSDSQGAGASLDLPSSRLSTTQPSVSGSQNAKETKDWKPPFKSSSPSPPPNAGLDPLSTQIYLRTNSNTAEPTIAQRILNQGRSDSPAADNIQRQSSELSKSPNITQDSSKDRRKGVSFLSRLGMRGSWRKDDDMQESDSELGELRTDGTYARALTSVIGAGGGYIPLHKEPPRYIRVKAHNKKDRDYNHLFLAQELTASEHKHTHGRAVATAVGSKILRGGDAIWAAEFSLDGRYLAVAGKDQIVRVFAVISTPEERKAHEEEEAQNGTHGEKLSAPVFRTKPVREFKEHTGEVLALSWSKNNFLLSSSMDKTVKLWHMSRSDCLCTFMHKDLVTSIAFHPTDDRFFLAGSLDAQLRLWSIPDKSVAFQAPVGEFITAVAFSPDGNIAICGVLSGLCTFYATEGLKLKYQIHVRSSRGKNAKGSKITGIRTMTTPSGPEAGTVKVLVTSNDSRVRVYNLNDKVIQVKYKGLENQSSQINARFSDDGTYIICGSEDRKAYIWKLGTQDEIKDKQPYETFDAHPEVVTTALMAPSKSRQLLSASGDPIYDLCNPPPVMLRSLEESTPSHSALSDEDHGDSLHSNKKPEETPAYIERSRHLDGNIIITTDRTGKIKVFRQDCAHKKRQQGLWESGSRLGNRLSGVGRSGSVMTRTSASSRVQSRRGSLNIPGPNPIQLQHASDRINSWRQDIDGGRPSMNNTPARSERSMSPTKPGQSPINSAANLAPESRRKPLPTSPISRPTPTSPTGSGLSNRTTVRASHDRERNGITSPPTPSFSLISASDSEGVNDKEGSFWNLSRWRSSRQSLRYSSALNTPASPNGSPNPGHSRSGSQFLSVRERSSPRMSLGVDELKPPRQDVANRRRSAGPRLTSRLSVQGDQKNGFEDQIETHEEITPSKKRVDSGVGRISNESADSAVQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5C8</accession>
    <name>S0E5C8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431985.1">
        <property type="nucleotide sequence ID" value="XM_023579086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5C8"/>
    <dbReference type="STRING" id="1279085.S0E5C8"/>
    <dbReference type="GeneID" id="35399308"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05829"/>
    <dbReference type="HOGENOM" id="CLU_129819_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009732">
        <property type="entry name" value="DUF1304"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38446">
        <property type="entry name" value="BLL0914 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38446:SF1">
        <property type="entry name" value="BLL0914 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06993">
        <property type="entry name" value="DUF1304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13030" checksum="4C16125C89BC9F98" modified="2013-09-18" version="1">MGVIGLTASGLVGALHSYILVLEMFLWTKPRGRKAFRLTPEFAEQTKTMAANQGLYNGFLSAGLIWSLLHPNPEFSKQLQIFFNGCVLVAGAYGGLTASKKILYIQAAPAALSLGLVLLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5M5</accession>
    <name>S0E5M5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432288.1">
        <property type="nucleotide sequence ID" value="XM_023579454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5M5"/>
    <dbReference type="GeneID" id="35399637"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06160"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_7_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="272" mass="30052" checksum="BBEF0046A1055B17" modified="2013-09-18" version="1">MSKPWIFVCPSTRGIGYALTRHLLQKTSLPVLATARLQHDPETVKKSLLEGLPEKEGLTKRLSIVHADVTDEESLINAASRAAELFPPDKHHLRLACAIPGALKPEKNVNQIDAEASLAQFRINTMGPLLLIKHFDKFLPRRSSELEDSPKSDEVKMPPYSVWLSMAARVGSTSDNRAGGWFSYRASKAGVISLGKSYDIFLRGRSGDKAISIAYHPGTVKTDLSKGFWESTKEGKLFSPEFAVDRLVKVATGLPLEGRGKCMDWNNKEILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5N3</accession>
    <name>S0E5N3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MUC1-Extracellular alpha-1,4-glucan glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432145.1">
        <property type="nucleotide sequence ID" value="XM_023579278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E5N3"/>
    <dbReference type="GeneID" id="35399480"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06002"/>
    <dbReference type="HOGENOM" id="CLU_254227_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485607" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1409" mass="144290" checksum="2186140AFD875430" modified="2013-09-18" version="1">MRPPNIPLITVLSVLLLLSCLLGSATGLGPQQHRGARKDVRGNNLIEARNPLGKALADGYGPPPPYYTGEPVAPTDLTSHHSLEESTATETQTGASQAGVSSKSNVSSHYETVSYGSSSLSVSSALETGTAMITVGSSAKAGSTSGSKALSSVHLTASGSFLGTETSGVKASSISLGQVSTISNSPLTGTYPSADTSSPGTETEFPSGSASSATVSVFFNETKMITESVSHTQAVLSAEVSGDFTTTELASRLESSVTKAGLTTTTTRMLNVTVTVAPSSSSGIASSLSSLTVPMTADETTTVTVIPQQNSSELSTEGLATDTDSAEGSTLGSLATESTKSVTIQSTLTKVAISESTQKSTRASSIPANGTVSFTTTTTTTTTTAYFTTTIGVPASSSVLSNSSGISRTTIVASGDSSGAVTGDSSAIMASITVALSTIVTTSKAHTALNVTSPATSSPFSSVPTSVASASVDVSESNIATTSNQTSSETLFASTALPINVTSHSVTEPFVVTTVSDGSVITIFPGGIIPTGIATSMMSISVSTQYSTSGPSRFNSSMSIRRTSLSSQTDSWLDWPTSTLTTSHTSEVTLEVPSLAFPTSWLSIITAPMTPPSVSTTSTRGPSDGSTHGNVTVIKTTMTSTITSSLTPTSLSSSGNVTVAHTTSGYNFSKSVGSVKSTFSSRSTSLGISTVIISKQPTNFPFPTNTSLVWQSETSSASLSESDKTIGPKASDVTFSLTTAGFNSTTPYTNSTTVTASETYPSSNTDQTQSIITAGASGSRNTTRSAQWFTISTVQTTTRTGSDLVSGTQTLSDTAAATPQPPASLNVTLTTISDSTYSKTFTDVKITIIMPTSLTTSESVSLPTVSTSTAPFPLPSNTTLTGTSTSFPPSGTGPRFTITGTLGDFSTSSMTISPSIRTTYLTVNTTVAGITADTSASASGTNEPLFPVSNSTSLGTTSLSTIASWRPDPEPWTSWPTLSLTNEPGVSTWTVNSEIPQRTSYTRTTTKSLTSTLGEPNMSHSSIHNLSSATSGSTSYTRTTTLTLTTTLEEPSTSPSTNGNRSIATSESISYTRTTTIFRTTTMGGPGASSSALSSSSGGASLSTSYTRTTTLTLTTTLAEPPKSQVSGGTVTNSSVSTWANVTSGVAGFTSTETISLTTVTSSLSGTLATFLTTGSAKGVSTSLESSALAPIPVGNSTLSEASGRTSSGIDTSTGTHLLTSSAAAAAPCESTSTSSSTCTESVYDTPTHTAIPASTDCLTETNGPDLSLSYVSAVTAAENVSSTCNTTSSTVHWSNMTHTFGVKDTETSTYQPLTTLRTVTKAQTGGELGSTGDDYPTPTDRVPQDPNFPWGNDSPIHRHQNSSELGPGENDGDGDGGLSKRISWRPRWENVRDKLEGLWRGQTLKSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5V8</accession>
    <name>S0E5V8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431172.1">
        <property type="nucleotide sequence ID" value="XM_023578348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5V8"/>
    <dbReference type="GeneID" id="35401505"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08028"/>
    <dbReference type="HOGENOM" id="CLU_2527636_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9306" checksum="C0D555269435F998" modified="2013-09-18" version="1">MSSPASHRDESTDLSPTVTNTSMDSEPKKAGKRVLSCVLCQQRKKKCDRKTQNSLHSKFASSAKEAQASESRSSRKACEMRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6E7</accession>
    <name>S0E6E7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432465.1">
        <property type="nucleotide sequence ID" value="XM_023579670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6E7"/>
    <dbReference type="STRING" id="1279085.S0E6E7"/>
    <dbReference type="GeneID" id="35399832"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06355"/>
    <dbReference type="HOGENOM" id="CLU_048587_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF2">
        <property type="entry name" value="DLTD N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G00380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="42"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="298" mass="32910" checksum="C40481BC7C3BFB00" modified="2013-09-18" version="1">MASHKDVNIPTYDGLKLKGTLFSVGQKKPCIIMSSGWSGLRSHFLPEFATRFNKAGYGVLTYDNRCWGDSEGLPREQVDPTLQTRDYFDAFNFAVTQPEVDPTKVIYWGSSMSGGNAICAAAVNHNIAGVILQVPFISGEWLSRMPGASTSLLLGERAKATTEGSPSKIPNFPSSLDELESGASQAVLKDPQSIPFIVEMEQRGLDWSRTCTVQSLTYALLHEPLAYIHRISPTPMLMIVADQDVTTQPHLQLEAYNKALEPKKLVVLKGMGHFSPYFGTPFEENIQAQISYLDELFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6L9</accession>
    <name>S0E6L9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to enolase-phosphatase E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431467.1">
        <property type="nucleotide sequence ID" value="XM_023578190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6L9"/>
    <dbReference type="STRING" id="1279085.S0E6L9"/>
    <dbReference type="GeneID" id="35401364"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07887"/>
    <dbReference type="HOGENOM" id="CLU_023273_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="351" mass="38989" checksum="05F51D985B22985E" modified="2013-09-18" version="1">MTLNLNEFDVLVFDIEGTVCPISFVKDVLVSRPVFLFVSLRNPSDFTPFTYIRPPPSVPLTTSGPGPPYGYHQISSQPPLPDVLRPAAGLCTQIPGVHAAEPSSAKLRKSRARAAENFKPSTSFPTPPFALFTDFARFFPYALEALPKVLDREWDSPEFAKYRDAFPEEYRNSRSDFEAHVRDLVKRDVKIAYLKSLQGYLWLQGYKSGNIVAPLFPDVEPFFNEATQAGKKIIIYSSGSVPAQKLLFSHTNSRKSDMTPLIADYFDTTNAGPKTEVDSYAKIISEHPEHKDVDRWLFLSDNINEVKAAVGAGMRSVPVVRPGNAPLPPDEPLSKLAITEFKHSEVASLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8J9</accession>
    <name>S0E8J9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_08731</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433295.1">
        <property type="nucleotide sequence ID" value="XM_023580534.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E8J9"/>
    <dbReference type="GeneID" id="35402207"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08731"/>
    <dbReference type="HOGENOM" id="CLU_000688_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23120">
        <property type="entry name" value="PEX6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1032"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1302"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1318"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1351"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT71216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1388" mass="149911" checksum="BF50FDDD9DDCDAC6" modified="2013-09-18" version="1">MASSSKPALTSNRRRNRRRRQDKPAITAKLVLDDHIKSDVGIVSEDIFRDLFPHLGNAQLYQGATEDVHHIAIAPWIPNANPTNSPWSIVPIIESSALAPSTVRFSPSSASLQSFAVTLQQVAPSKLSSHSRGGIEILVLDVAPVPLETVFVSLESELTKRLENGEGTFFRDHPASSKAKGADSTPDGRLVTSLRAALSSLKVVHAGDLFPLPLPPHPLTHVPPNPGKIMLCEPVAQGVLTESTKIILMRGRVHTKQIRRVASMTASQQLNGVPEDEDDTSNDQFYSAAEDRDKSGMTTEDMESATETEPDMSDFDNEDELSDDSMDDMISLQAPTLPTTNASGVSTLQPGTPMTVGTLRGRKTNGIATPGSVFSNFTATTARPDRPRGRLFKAQGLMEQIPTDLLHPKPSLEDDEEARIYVDVTSLSRIGCFSGDWVRIEAAEEPPANGFGAFGLGSFGQVESEPAKWRPVRVYGLPEGYSQRPMTRIPSAKHGERRLSFFESQIQRPASPTAYASPILLANLDDAPYLRLAPLKKASYQGKGTIPRFTSAARPPYARDITIHHIRTPISAERAFQTAVLGGLKRYFAHKIRLVRSGDLIAVPVDAELGRTLQEMPGAGGSEVDDVMALTAGGQEGGKQPSKFDSVAWFKVGHIQIQKADEDEDGSAEAFWGSVACIDSSSVAMHGSGFETSRIPGIKQSTWQYYLGLKKTPKKASESTPAPIQEPELPYVSPLRRQLRELIAAATSARAIHLKMPPVAILLTSTHRNIGKLTLASGACSDMGLHTYKIDAYDILSEGSGSGSDVKTEGFLRTRAERAMSCGPDCCALLVQHVEALTADRIESTIKEILEDTRVLIATTNEVDKVPDGVRALFTHELEMTAPDEAERESILKSIISDRGVSLEPSIDLNSIALKTAALVAGDLVDVVERASIAQQSRLEQLSAKNTHDNTIITVRDVQVAGGPLARCLTKGDFEIAVEAARKNFSDSIGAPKIPNVTWDDVGGLNNVKEAVTETIQLPLERPELFAKGMKKRSGILFYGPPGTGKTLLAKAIATEYSLNFFSVKGPELLNMYIGESEANVRRVFQRARDARPCVVFFDELDSVAPKRGNQGDSGGVMDRIVSQLLAELDGMSGGDDGGGGVFVIGATNRPDLLDPALLRPGRFDKMLYLGVSDTNDKQQTILEALTRKFTLHPSVSLASVAEKLPFTYTGADFYALCSDAMLKAVTRQATAVDNKIRAINSDPTTQHPISTAYYFDHYATPEDIAVMVQEEDFLAANDELVPSVSAGELAHYEHVRATFEGVREKEPENKPPPVQRVVSGASTSSKGKGKVVASGSSKGKGKAIALTSGDECDEEDEVDDMNGRSKGKGKAPMGFQDGTASDDDGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9D7</accession>
    <name>S0E9D7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to endo-1,3-beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431138.1">
        <property type="nucleotide sequence ID" value="XM_023578309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9D7"/>
    <dbReference type="STRING" id="1279085.S0E9D7"/>
    <dbReference type="GeneID" id="35401471"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07994"/>
    <dbReference type="HOGENOM" id="CLU_019533_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02182">
        <property type="entry name" value="GH16_Strep_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495727" evidence="1">
        <location>
            <begin position="18"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="28"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="281" mass="30833" checksum="40CB3BE6462F3035" modified="2013-09-18" version="1">MLNFIPIIAGLASLVSATSAPTRPDLKLIWKDEFTGCQGCSPKTNNWNTALNINSNNELQVYSTSNKNIQLSGGDTLQLVPWKDGKGEWTSGRLESKKAFHADKNKALRVEASIRMGDSARKQGIWPAFWMLGDALRHGTGWPLCGEIDIFERVNGDLTGFGTVHCGHEGGGPCNEPEGLGQRVTIPDNEFHAWSVVIDRRASSWQDEKITWLLDGQPFHSITGKTLNDEGTWATLAHSPMYILLNVAVGGTWPGNPNKATEAGYKNMMEVAYVAVYETTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAI0</accession>
    <name>S0EAI0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_05366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431558.1">
        <property type="nucleotide sequence ID" value="XM_023578569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAI0"/>
    <dbReference type="STRING" id="1279085.S0EAI0"/>
    <dbReference type="GeneID" id="35398845"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05366"/>
    <dbReference type="HOGENOM" id="CLU_004542_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="10">
        <location>
            <begin position="668"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT69478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="747" mass="81771" checksum="240AE06420948F37" modified="2013-09-18" version="1">MKSVILTIQAHQHQAHDHEISQPLTFDKAVKEVEQGQDSSAVAIRLLAEMSSAERLHLLYGDVPFWEGLREILCDRYNRRPFVMGAIPRLNIPGVKFTDGPRGIVMGSSTAFPIAMARGATWDIDLERRVGNAIGLEGKAQGANLFAGVCINLPRHPAWGRIQETYGEDPILLGEFGTALTQGVQNHIMACVKHFALNSIENARFRVDVQVDEDVLHEVYLAHFKRVIEAGVASVMSSYNSVNGEWAGQSRLLLTEILRDQWNFAGFVMSDFIFGLRDAAISLKNGLDIEAPFAQQRAMHLNDALKSGGISSVDVGKAAMNILRTKLEFGSLLVQEAPDASVVFCEEHRQLAREVAGRSMVLLKNDHIHGNPILPLKTETLSRLAVVGRLANKPNTGDKGSSQVFSPTIVTPYQGLKSEILSAEVILEDSDNPEAAREAAKQADVAVVIVGYDAGDEGEYVVPSLQNDPCLSELFPPTSNPGEEEMLSIVQGNPAQGKQESALEVGAGGDRRSLRLRPRDVQVINAVASVNSHTIVMLVCAGAVIMEEWKGKAPAILVSWYAGAEGGHALADVLLGRVDTGGRLPFSIPKDESHLPELDIEASSIKYDRWYGQALLDKLGVDAAFPLGYGLSYTQFRFRNLECVYLTEQRIINVALDVENIGLRSGHDVAQVYGYPKMAEFPHRVLLGFGSVYLQSRESRRICIEASLRPIERWVNGKFCLLVSSVEIEVAGHAGDKEAIRKVCNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB18</accession>
    <name>S0EB18_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellobiose dehydrogenase-like cytochrome domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434142.1">
        <property type="nucleotide sequence ID" value="XM_023581444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB18"/>
    <dbReference type="STRING" id="1279085.S0EB18"/>
    <dbReference type="GeneID" id="35407392"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13938"/>
    <dbReference type="HOGENOM" id="CLU_081649_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF1">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485061" description="Cellobiose dehydrogenase-like cytochrome domain-containing protein" evidence="2">
        <location>
            <begin position="37"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="3">
        <location>
            <begin position="51"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="299" mass="30975" checksum="0D444BDBB1794871" modified="2013-09-18" version="1">MPFVRNIHNRRTTRQRHINPHRILATSLLLPALALADDEPTSSTDQVSEPFVDQVTGLTMERFFGVRTSFTFALALPDTAPANGTAGSFIGQLQFPLANGEGWGAAGLTGDMEGNFILAAWPDGKGGVMASFRQAIEEDNPAEVKGNFKVRPIPDGVSVNETSLLYTFLCESCLDSTLGLGPEAAVGNAVMGWALSERPPRGDPSNPGAFLGFHERGFGPFTARLAQAKTAGFDAVAAKALAPVGDSGSAVATVPNAFLDGGSDDEDSGDEGAGTGIGVGGGNDVDSDSGDESGDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBF4</accession>
    <name>S0EBF4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434053.1">
        <property type="nucleotide sequence ID" value="XM_023581342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBF4"/>
    <dbReference type="GeneID" id="35407485"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14031"/>
    <dbReference type="HOGENOM" id="CLU_121025_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="128" mass="15515" checksum="9DAF1BEA9F881E72" modified="2013-09-18" version="1">MSASAEQQNEIAKLVEQHGAVPPPWFMFPKQHPYSIGWRMGAGESYIMMYWTWWEQQKEKLDEKQRIEYFRRWPPPPEWLIWMIEAIWDLDPKDFEDDDDYSPYLKRTETLGFGSEDDYKNAMRDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECG2</accession>
    <name>S0ECG2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to TGF beta receptor associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_12191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434413.1">
        <property type="nucleotide sequence ID" value="XM_023581767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECG2"/>
    <dbReference type="STRING" id="1279085.S0ECG2"/>
    <dbReference type="GeneID" id="35405647"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12191"/>
    <dbReference type="HOGENOM" id="CLU_008225_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="46"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT72335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1195" mass="132286" checksum="AC8E7CAFE4B59A25" modified="2013-09-18" version="1">MTSDGSGDGPSITSPGLTSTSREVGPYVLRTLLDEVPLSADGSKDDIKINCVDYLDANLYVGTSASELLHFVQIPPDPNDPSGQPVYILASRLCPQYVETPGTPSSRPGVQQILLLPRVGKACILCNWTVTFYSLPELSPVFGTTLVKNCSWIGGIDLNEPLLDDGSAERSGGVTILLSLMRKIQVVRVGEDARAFKKIDFSGSTLSVRRDSIACVADSKSYALIDVEQQLKIPLMSISSLEETTSPSEIGHAQSIGADTTSGLLRSSSSTGNRTSSEAPSHSRSTSLGGSILDSIRRQDHRGNEGEDFFGRNTSPQPSISPRPSMERASTPNPPSLDKPLPAAPSPSGTPSQSTDPRPRPGSVFLKPHITSPTPDEFLIVTGTDPLEPGIGMFVNLDGDPTRPTLEFTRYPKEVVVDSPPLEVNSSQPSSMQEEDGYVLASMTREKDSLEYGLEIQRFDAGSDPNPQKFWLTAREADGVYGIRSLAGSEETRFDEIVQKLSQRRYTPFSVSISPGTPDPSSSAKTPDARTALSIEHLSKEKELFDRNIDSQDEESLPEEWEANRNAEGEEFARQLAKAQARLAVWSGSRIWWAIRNPLLIQLDAALEAACVGDVFSPAELDRQAIFTTINSIRGREPQSELEFMTYGYIRQKAGILLLTNLLKSPEDKQFTEKDVKALEEVLIESGLDPRVVLSLIPSVRNEIIEGSRGIWIYGGVRRTADAYLRSREFQMTSKDSIGTLEPRTMHFLRRFLGTWRKKKGFGSVADEREVFHTVDAALLLVLLEIDQHSPKGLGKGGVVRSELYEIVDKGVDCFDRAVDLLETYHRLFVLSRLYQSRKLSGDVLATWRRIIEGQQDVGQELREGEQRVREYLTKIGSQALVQEYGVWLANRNPKLGVQVFTEDKGRAPKFEPAQAVAILREEAPDAVKYYLEHLVFGKGHTTYINDLMAYYLDVVVHDLESSEESRTLVRATYEAYRALQPPKPAYSHFLRDNAPDDNEVWHSRLRLLQLLGEANDYDAVAIRDRISRLPDDLLVPETIILAGRECKHDDALRLLVHNLGDYDTAVSYCLRGGASTTGAAPSQRPSFEEQRRLFNVVLHELLALENISDRVEQTGALLERFGGWFEIDDVLSLIPDDWSVDIIAGFLVGALKRLVGERHEAMLTRALSGAQNLRVSYDRVAKIDEKGPSIEASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECN8</accession>
    <name>S0ECN8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433646.1">
        <property type="nucleotide sequence ID" value="XM_023580964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECN8"/>
    <dbReference type="STRING" id="1279085.S0ECN8"/>
    <dbReference type="GeneID" id="35401822"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08346"/>
    <dbReference type="HOGENOM" id="CLU_089016_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="295" mass="34789" checksum="CD5597BC262E44AD" modified="2013-09-18" version="1">MDQSFPQFPKLPPEVRATIWEHTLPEGDGGAALYMYNMDWWAQYSPPGVAFHDMTTQSIQQLSRPPRVQVPIPTCAAVCQEGRRVVEQWRKKNNLEWYFREETKGDILVRRFDAERDILYVSRHKWESFQLLAVDWENDDEHAAVIRIMESVKYLALPAFTAYYSISNIAGLLPWMKNIKAIYVLWNELPKAHIIKRQLPDVAHIAEVKIPLDAPVQPRWELDKFLRREDEVEFHYTDEETGREYVEDGELAEWLDDIDDLWNTTQVDPEIWDKDEEKLKTPQIHVTAKDLPTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECY6</accession>
    <name>S0ECY6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to STAM-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_08216</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433766.1">
        <property type="nucleotide sequence ID" value="XM_023581108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECY6"/>
    <dbReference type="STRING" id="1279085.S0ECY6"/>
    <dbReference type="MEROPS" id="M67.A14"/>
    <dbReference type="GeneID" id="35401692"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08216"/>
    <dbReference type="HOGENOM" id="CLU_023304_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="354"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT71687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="531" mass="60610" checksum="AD0AF9CA3B4959FC" modified="2013-09-18" version="1">MDSRIAMRPTRPQTVKELVAQAENFKFNTNIPVKHWTRAAETLYQEASFAVSDGDFGRAYMMLYRHSVLVLQYIPTHPQFKDPENKKVYKTLSRRIPRVIQDLEQLKPEIENAVKEWERMALSSKANAGPEPSSRYEQFAARDPSLTGNAKILDAFDNQDLAVDLAQKELMRRDTARRATRQAGITDEDIMSRRRGGRWDQWDGARMGDDEDLRRQMEATRHALDSAQERRTDDDYRPTSHTYNYPSISRPRAVDYEGQTPIPSIQPSRPPKEPVAPPPKEPLHTPSLQSLPPPLPQKVPLPGYAPLIPSPSPQPARPEVPRKEALDTPPALPQKERLTFKPGAYLENGDPIRSLFLPKNLRQKFLDIAADNTRRGLEMCGMLCGTPINNALFVRCLLIPDQKCTSDTCETENEEVMFDYCMKEDLLLLGWIHTHPTQTCFMSSRDLHTHAGYQVMMPESVAIVCAPKFQPSYGIFRLTHPPGLDHILNCNHQDTFHQHSIDNIYRGAGQPKGHVYESDKLDFYVHDLRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECY8</accession>
    <name>S0ECY8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to raptor, a binding partner of target of rapamycin (TOR)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_06217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432342.1">
        <property type="nucleotide sequence ID" value="XM_023579518.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0ECY8"/>
    <dbReference type="GeneID" id="35399694"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06217"/>
    <dbReference type="HOGENOM" id="CLU_001136_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030874">
        <property type="term" value="C:nucleolar chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031139">
        <property type="term" value="P:positive regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000514">
        <property type="entry name" value="TORC1 growth control complex subunit Kog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000278">
        <property type="entry name" value="WD repeat-containing protein mip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="157"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1281"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="894"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="904"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="947"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1396" mass="159025" checksum="A36F5C171C137D11" modified="2013-09-18" version="1">MALRSDVNGTSAPTVEPNGTASAARPRMNGRSTSNDATRSDDDDQRPLSAPNRRNGSIVLETRDDIEHHQKTRPTKPMLLRSKSDYAPRAMEEPEPTEDDIPEWGARHGFEDHYQSEDIISQLANNWYMYFTDKRHETTGKPKPLQYELQDWRQRDRLKTVSAALAVCLNIGVEPPDQLKTNPGAKLEAWTDPTIPPIQKALENIGKSLQAQYETLAIRARYKQYLDPSVEETKKFCISLRRNAKDERVLLHYNGHGVPKPTASGEIWVFNKNYTQYIPVSLYDLQHWLQAPTIFVWDCSEAGNILNNYHRFVEKHEEEEEEAAERDPNYTKTNFRPYIHLAACAVKENLPTNPLLPADLFTACLTTPIEMALWFFVLQNPLKTNISPERAKKLPGRLQERRTPLGELNWIFTAITDSIAWTTLPRDLFRKFFRQDLMVAALFRNFLLAQRVMTVYGCHPQSYPKLPDTHQHPLWETWDLAVDMALAQLPMLEKKESEGFDYEYQNSTFFTEQLTAFDVYLTRGDAMAQKSPDQLPVVLQVLLSQQHRVRALILLGRFLDLGPWSVQLALSIGIFPYVLKLLQSAAAELKPVMVFIWARLIAVDLSCQQDLIKDSGYSYFAQILKPSEGLPVVDSDEHKAMCAFILAMLCKDYKNGQMVCNQTEIMSYCLTHLQNEENPLLRQWACLCISQLWQDLPEAKWRGIRENAYVKLAYLVRDPCCEVRAAMIHAMTTFLGIPDLTEEVARIEESIAWTILDMGNDGSPMVRKEFIVFLSHFAIRFESKFLVAAYEQLVEEKEYLIFPPQDDGQEHKMGLHYTRPDNRNKDGTINPMAHGLSHNTVYMALWKLALVLSVDPHPEVQREATIVVDFVHNALLSSKVGVQTQLVMAEIRKRTARTAHKHTPSASQRNNAPGTSNSQPLPSPGLLRRTASLLFPSLVTNEDKSRPTTPTLPRSPSLKLTPNQVPVPAEQNDRPSSLAQYNVAHEPFSGAYKERDLMKPPALPLRSKFLEWSIEYFREPQMKPSEADEPGSTEYNERLWRRARNETIFRETQPLKQQAGSHKWNNQLGIINNGAQPAKMTFHQFEDHLAVADDGNTVYVWDWKKQGRLSRFSNGNPEGSKISDMKFINEDDQAMLLTGSSDGVIRVYRNYESDRAIELASSWRALTHMVPSNVNSGMVFDWQQVTGRVLVAGDVRVIRVWYAAYETCVMDIPARSGSCVTSLTSDQMTGNMFVAGFGDGAVRVFDTRNRPQESMVRKWKDESDRQWIKSVHMQRGGQRELLSASRNGKVKIWDIRMDKPLHSFQTTRDTLRTASTHEHLPVFAVGTSAHAVKVFNLDGHELSNVEPYSSFLQQNRSSPISATAFHPHRPILGCAARGDQHINLFTCEKSESLYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED82</accession>
    <name>S0ED82_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433876.1">
        <property type="nucleotide sequence ID" value="XM_023581240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED82"/>
    <dbReference type="STRING" id="1279085.S0ED82"/>
    <dbReference type="GeneID" id="35401575"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08098"/>
    <dbReference type="HOGENOM" id="CLU_030794_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485491" evidence="2">
        <location>
            <begin position="21"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="593" mass="65600" checksum="F1131E8559FEB4CF" modified="2013-09-18" version="1">MSSALRAAGVALLAITATAASTPAKDWTSLKLLTKSADAQVQTVIDGKNASLTGSPRSLTREVRRLVTPFVWPNSTYYHDESLLPHIEEMLSVLVKVQHDDGTYTVGNRHSPPDTGFLIEDFGIMVRILERDDHEASQPFAKAMRGILKKAAPGLAKGGIHTPNHRWKICSALARISNIIEDPSLIERIDEWLAEGVDIDADGIYSERSPNYYSAVSNPSLLTVAHELNYTELVSFVRKNLELSIEHAEPNGEMETIQSRRQDQSQPPGDNMGNFYPQFRELALLDKNGRFAAMARLIEKRVGAQLGDFLGNLIERPELAAELPKPKQPFSDFKKHYKSAGLVRARRGKLTVSAFGGSDWYTMDGKKAEFYNRMGSGLSTNPTMFRAWNGKAVLEAVRLSASFFSMGNFRSNGVELSKDGTISLGSEIEVPYYLPIPADKRDDNGTYALSKSVDGRFYAMLDFTNRPTSVRRLKTDVEIKPTKKGYDLDFEVTGEDNVELTFELTFREGGKFKGVKEILDSDNTTIYHLIEGKGEYSMGDDKITFGPGNGKGLIAADAGEQYSWHGGNLTLQGSHVYITGKTPLKYTLNLGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDB6</accession>
    <name>S0EDB6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable proline racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432462.1">
        <property type="nucleotide sequence ID" value="XM_023579667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDB6"/>
    <dbReference type="STRING" id="1279085.S0EDB6"/>
    <dbReference type="GeneID" id="35399829"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06352"/>
    <dbReference type="HOGENOM" id="CLU_036729_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047580">
        <property type="term" value="F:4-hydroxyproline epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.10:FF:000005">
        <property type="entry name" value="Proline racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF5">
        <property type="entry name" value="BIFUNCTIONAL TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE_2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029792-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="346" mass="37822" checksum="554F40A5EEA847A8" modified="2013-09-18" version="1">MPFKRSFNTVGVHCGGEVCDVVVGGVRDVPGKTMYDKMMHFWKHEDHLRNLLLNEPRGCSAMCHNLVLPPTNPEADYGFIIMEHEEYPPMSGANTVATVTCLLETGMVTMQEPETVVKLDAPAGLVTAYARCENGKCKSVRFHNVPAFVFATDKEISVPELGTVKVDIAYGGMIYVLVDAASVGLKIKTTEGAKLVKVGERIKKAVMEQTDPVHPENPGIHGVTIIEFTEPLYEYKDGKAANNTVVVSPGRLDRSPCGTGTCARLAVLHAKGELKEGENFYHRGITGTEFVGRVEGTTKVGEYSAIHPSVEGQAWITSFKQVVLDSTDPFPEGFRVGDTWHLDPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDE9</accession>
    <name>S0EDE9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to ATX2-Putative Golgi transporter involved in homeostasis of manganese ions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_08586</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433946.1">
        <property type="nucleotide sequence ID" value="XM_023580696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDE9"/>
    <dbReference type="STRING" id="1279085.S0EDE9"/>
    <dbReference type="GeneID" id="35402062"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08586"/>
    <dbReference type="HOGENOM" id="CLU_028824_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485130" evidence="9">
        <location>
            <begin position="18"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT71867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="444" mass="47361" checksum="836AEB028AED1F9C" modified="2013-09-18" version="1">MGGVLLLLGLCLVMALASFLAGALPLSMSLSQSQLRLLSSVGVGILVGTSLIVIIPEGIEAATAPAEAAHMHRVRSLVRRTPWSHAVLKRGLPESIVTISTGSIEKRNDELDTEALVRRIINAAARNGRVKRADIEAAIEATGDDAPAIPGAGDAAKDSTTDNKGSEKAESGKEGQQNHDHDHEHEHEQEHEKEEAHEHAVPTFEIGFSLILGFLLMFLIDRLPRHATESLHSTPQTRHISLDNLNGDSASVDEEADGFLGSLTPTPRRARSLATTTGLVIHAAADGIAMGASSTTSDMKLGFIIFAAIMIHKAPAAFGLTSLLLKQGLSKRAARGHLIVFSLAAPFGALTTWTLITLLGGGKVESDHWWTGMLLLFSGGTFLYVAMHAMQEDTTPHTHDHGINGYADSNATAQRKPKGPQMRDTLATMGGMLVPLLTQFGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDT5</accession>
    <name>S0EDT5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable NADH-ubiquinone oxidoreductase complex 1/LYR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435149.1">
        <property type="nucleotide sequence ID" value="XM_023581622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDT5"/>
    <dbReference type="STRING" id="1279085.S0EDT5"/>
    <dbReference type="GeneID" id="35407233"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13779"/>
    <dbReference type="HOGENOM" id="CLU_141157_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="69" mass="8202" checksum="9330AA49043214BE" modified="2013-09-18" version="1">MSLNPQLRRQVIAIYKELLYMGREYPLGFDYFRPRLHKAFISKAGERDENKIRQGIAQAEYVKKEIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE20</accession>
    <name>S0EE20_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435147.1">
        <property type="nucleotide sequence ID" value="XM_023581607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EE20"/>
    <dbReference type="STRING" id="1279085.S0EE20"/>
    <dbReference type="GeneID" id="35407247"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13793"/>
    <dbReference type="HOGENOM" id="CLU_066049_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="270" mass="30919" checksum="532CE9D00939DC6F" modified="2013-09-18" version="1">MDTNPEIVQPADWQTGEAVPVFLIHDGGGTTFSYHCLEPLRRPVYGIYNPKFHSGEPFDGGLSDMARLYTGWIKETVEKPDFPRRRNAAGKIRLLLGGWSMGGHLSLEIAKQLENSNIDVIGILMVDTIYPHRFSSEKRKMPSEDSKEGKNKNQILADLAMADARRMIQAWTPPVWEAGRRPRISLLRAKKAVPSADGTDLVDWSREERNLGWDMYDKDFFADVVDIEGHHYEVFKFEFIEDISTKMKKALDDLEWVALDDEDMNMNETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEX9</accession>
    <name>S0EEX9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435333.1">
        <property type="nucleotide sequence ID" value="XM_023567965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEX9"/>
    <dbReference type="GeneID" id="35403530"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10063"/>
    <dbReference type="HOGENOM" id="CLU_082501_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="227" mass="25506" checksum="4025297A509F0DD8" modified="2013-09-18" version="1">MAFVRPLLYVALGLLMVVSIIELSFISSMVGWLHGNASGTFSFEYRGTRHNLKGEPANLIVDQGHTSNGAAGTAFVLIGCGGILALILRNRQNPGKFSRFLYNTWLVFNVLSLLLILTALIYTFVVTNNHNGQRINPGVAAGLDDDEKYPLQSWTPQNWFSAFLKLDLTNSNERNDIEHHLRLMRGWQYNLIPFFIIHLAETGLALWDAMLRRKEPVPAYAPPKHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF12</accession>
    <name>S0EF12_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to monocarboxylate transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435609.1">
        <property type="nucleotide sequence ID" value="XM_023568405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF12"/>
    <dbReference type="GeneID" id="35403134"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09666"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="242"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="450" mass="47747" checksum="97CFB4EB9AA8D762" modified="2013-09-18" version="1">MTTTTSLELASIRPTGDDEAELPSIDALPPTDRGRRAYTALACCTIAQAPIWGYSVSFGIFQEYYSAHTNLKASPSAIASIGASQTGIMYLMMPVAFIVLNRLPRLRKWCGPLGLAITIISLTASAFAGNVAGLIATQGVLYAIGCSLLFSPISLYMDEWFVERKGFAYGVMWAGKSSVGVAMPFLFNVLLQRFGLKATLLSWTVASTAMTLPTLFFLKPRVEISHDSRPRPISFAFFGYASFWMLQFGIIIQSLGYLMPSTYLASYATAIGLSSVTGPILLALFSLASVPGSLIHGMLGDKISGAKVILVSSLGSALPVFLLWGLNRHISTMVVFVILYGFFAGGFSATWSGALQEVKGTNDAIDTSLVFGMLLGGRGLGFIVAGPLSGALISAGSPLASGDSLGYATKYGPMILCTGVTAILGAWAPICKIARSVGKKGLEKYARFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF85</accession>
    <name>S0EF85_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">FFUJ_12389</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434590.1">
        <property type="nucleotide sequence ID" value="XM_023581989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF85"/>
    <dbReference type="STRING" id="1279085.S0EF85"/>
    <dbReference type="GeneID" id="35405845"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12389"/>
    <dbReference type="HOGENOM" id="CLU_006515_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045005">
        <property type="term" value="P:DNA-templated DNA replication maintenance of fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002774">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="14"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CCT72512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="864" mass="96305" checksum="015258804CAE3AB9" modified="2013-09-18" version="1">MAHSEVEKVTQDLEKLDFHHPYTPYDVQEQFMKAVYDVLETGNGQVGILESPTGTGKSLSLICASLTWLRNRKSNQFEASIQESAEAYKDEPSWLVEQLLRRKREELVTRWEEREKRLETLRLKEKAQEERARKRRRVEDLVPSRSRVEDEDAEWLLDDPDNRDAGPQDALSGLSRETREVLASIGLGGAKKPEEEDDLLEEEIKIYYTSRTHSQLSQFITELRRPSFPPSLPTSLAKGEETKTEAVKLLPLSSRQRLCINPTVSRLGSVQAINDRCSELQQPKSGQKCPFVPKEDLLSQTHQFRDSALATLPDIEDLHQLGKSLSVCPYYASRTALPGAEIITLPYPLLLQKSARDALGVKLEGSVVIIDEAHNIMDAVANVHAAEIKLSDLRRGRAMLGVYVKKFGKKLKGVNRVNVGRVGRVIDGLSEWMDSALKFKQEHGIVDPNDLTRPKGIDQINMFELIQYIQESKLAFKIESYISHVESEDTNSKTPRPSSPVLHTLVSFLIAFTNLSSEGRIFYQKIKGPTPDIQLSYLLLSPTYAFSSIASSARAVVLAGGTMSPFDDYKDHLFPSLEPEKITTLSCGHVIPPENLCVWTLASSRPGAPPFEFSFQKRGDTEMITQLGLAILNLCSLVPDGVVIFFPSYGYLDEVVAVWQKSQGNAQPIWDRLAARKALFKESRGASSDEVLQEYSDAILGEQSNGKGALLLSVVGGKMSEGINFSDRLGRCVIVIGLPYPNIASPDWKAKIEYIETTTQNNLTAQGVAKEEAISRGKQTARDFYENACMRAVNQSIGRAIRHRGDYAAIVLVDRRYGTERIRGKLPGWIRGGLVKDSHEKGLGGLMGAVGGFFRGKKSKSQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFG9</accession>
    <name>S0EFG9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434665.1">
        <property type="nucleotide sequence ID" value="XM_023582077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFG9"/>
    <dbReference type="STRING" id="1279085.S0EFG9"/>
    <dbReference type="GeneID" id="35405923"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12467"/>
    <dbReference type="HOGENOM" id="CLU_021768_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="331"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="558" mass="63390" checksum="E5EEC2C6F0FB42A5" modified="2013-09-18" version="1">MNPPSPDVHKALNLVDRVPLEHPASALLRAYILEAVQPQAAANYVQHRLSADGHAGSLVADWIYVIDSVVSGKQPRAPTADEINAITKRDGGICCVTGKRGSLWDPVIVAPILPVPFPWLKQQNPSRVTELLEAFFGPQYFDWWRFYIDRAGIYSPYQTHWLVRRSVHEAFQRGVVKLIRLPSSMIEFRVEHVLIDDEQPVDVNGPIALLGDHSRQGIDKVDARLIGSHARFSRSLQLVNLARTIAPALFSEPKTTKYVPQQQSPVRMRSSNLGLGHTFVRPIILLWRLFPSKIRIAAYDLLRKLGSCFYRKDGDAQVQRLPFGLYLKFNSNPDTLRNEYNALKILEQKTSIPAPRVFDIVCQNNDEDDLSFLLMSRVPGTSLAICRDALSDQDCANLSVQLKDCVSQMRDIPKPANHDMAICNTLGEACRDPRIRDWSAVGPFPDEASFSQNLRFSDEPSRRGHKICFTHGDLNPRNILVERISNSAGVRGWRLSGIIDWETAGYYPEYWDYTKSMFESFRWPRRHNEMMSEVFSEFGDYSEELAVERRAWESGDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFP7</accession>
    <name>S0EFP7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to zinc alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435904.1">
        <property type="nucleotide sequence ID" value="XM_023568758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFP7"/>
    <dbReference type="STRING" id="1279085.S0EFP7"/>
    <dbReference type="GeneID" id="35402819"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09350"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="22"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="348" mass="37495" checksum="8B30BCDA2091B965" modified="2013-09-18" version="1">MASNSTLPLTMRAAQWRSIKGGIDKNLTLVTDAKLPKNASSLPKGQTLVKVAYASVNHLDYKIAEMPPASLIFSKPVTPGLDFSGTIVSTTLNEFQSGQKVFGRTELPIGGTLAEYVVVGSKGMAALPGSVELRDAACLGICGTTALQCMSPFVKAGGKVFINGGSGGVGVFAIQVAKALGCSHVTVTCSASNADFCRSLGADETVDYKSEDPIEVLKKKENKFDFILDTVFNDPDLYWRSHEYLKPEGQYVCVGLPPRFQTFKALFAINMLPRWLSGGKRKFKYHSVSANRKDFGQFADWMKEGKVKVIIEEDFGLEDAGRAYARLKGGRTKGKLVVRVGGEAGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFR8</accession>
    <name>S0EFR8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_09616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435657.1">
        <property type="nucleotide sequence ID" value="XM_023568461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFR8"/>
    <dbReference type="GeneID" id="35403084"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09616"/>
    <dbReference type="HOGENOM" id="CLU_007091_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT73579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="824" mass="90667" checksum="57861A8EDCF1FC23" modified="2013-09-18" version="1">MPGNSSPITLSTPSFFFNSPLDVSQETLTEATDLQDTSFDLPAETATAGGGTVSSAAKTEKKRRRPALSCEQCRRRKIRCDRSLPCVNCVKSKISPCTYAPTHIPASRAKKGTGHAGASDSNSQVPARSAPAIGSTQRQSPSNSSARQKSSSIPSSTVGSNSEASTVDALAARVKELEQKLAESCYITQPAADKFIQPDDQEAESAPMKGTVSKTRFFGQSHWMNGIHMFPGVFDMLKEAETRRNQHHGGFVKCKALGRTIKANRSKAVSTDKLGENIPERGLADQLVNAYFDTFEGVVRILHRPTFMSEYERYWQNPEASSQVFLIQLQLCMAIGATLHDDVFSLRATSMQWVHEAQIWLMVPPAKSRMTIAGIQIMCMLVIAKACCAVGQDLTWVSAGSLVRQAMYMGLHRDPRHLGNMSVYRSEIRRRLWATILELNLQCSYDAGGPPLLSSKHYDTRPPANLNDDQLTDEPDSDRRPTGDPETLTDMSVQLALQKSFALRLVIIKHVNEFRSKESYAETLRLNSELTKACRTLTETLAALSEAQRHQPRTIFTHFHSSLVQMFTYRCFLSLHQPMVARSALDPTYYYSRKVSLDSSLKLAQITGLSTPRYGTSSPGGSLDPVVSFNRLITNGAGVFRVIPTQTLFSVALEFIKKSEEQNDSLGGGPVMNLFELRAVLQSAETWFERRIRAGETGVKGYCFVVVSLALAEALEMGLPEEDVDQVVVDTGASMSIKAYDLLKEVAEREGLSLDEPGDEEAIHIDVPAIDSDAMQGIMEMPFDWMVMGGDLGLDGMGAFNWARGGMGMPQQFDSVDPSVVSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGL8</accession>
    <name>S0EGL8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_08395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433602.1">
        <property type="nucleotide sequence ID" value="XM_023580910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGL8"/>
    <dbReference type="GeneID" id="35401871"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08395"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT71523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="485" mass="54019" checksum="E07393141B07B548" modified="2013-09-18" version="1">MASKDGQDSTPRRHSLSDESDSNSAADEKRLVAKLDFYIIPLVMVLYLFSFLDRVNIGNARLYGLEEDLSLSSNQFQVAVSILFVTYLLFEVPSNLVLKLFTPRRWIAFIAAAWGIIATLTGLVNSYGALIACRLLLGAVEAGLFPGLTVYLTFFYTKRELALRVGYLFVSAAVAGALGGLLAYGIGHMDGLHGMSGWRWIMIIEGIPSFLLGVVTYFSLPNDAETAYFLDENERALMRSRHAREYGNTASSREFSKKDMMCAFKDWKVWAFCVAQFGVDTMLYGFSTFLPTIIRDLGDWTVAETQLLTVPCYFLGAAAYMSTAFLSDKLQQRGLFCVIFGVISVVGYAVLLADVSSGVHYFGCFLVAGGLYVVVGLPLAWLPTNSPRYGKRTTGTGMQLTWGNAAGIMSAFIYPASDKPRYIRGHAVTLSMVALGTVIYGFMLWWYRRENERRQAGLMDDKFRGMREDELAELGDESPRYRYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHG5</accession>
    <name>S0EHG5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436138.1">
        <property type="nucleotide sequence ID" value="XM_023568231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHG5"/>
    <dbReference type="STRING" id="1279085.S0EHG5"/>
    <dbReference type="GeneID" id="35403291"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09824"/>
    <dbReference type="HOGENOM" id="CLU_019703_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="Toastrack_DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="3">
        <location>
            <begin position="330"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT74060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="704" mass="76843" checksum="08C54D2A3A7DB9EC" modified="2013-09-18" version="1">MPAPYSDNLYSADSDDEHDALSPTDGYFHASSESSSSRSGQNVPHVPNVLVEDPTQLSRDAKIQEAERERRLLNTGGGSAEHNFESTALSHENASGSENPIASTPRSPPRASPLFAHPVDAPPAYSPSPTTTSPPTTVNNYQTFASTATMGRPEENRPLIHHAPESMSSPYNSAQQPSRWQQFKDSVSNFNIRKKVKTVLASLLIFSVIFMIFSSFTMQSSHGSHSNPVEDNDPVAPPSNDRDDFNWNPSRTCLEKPQHSAHFAEEFDVQSDRNLSIIQRMVKSNDLEGWSTHVSGEVILRPVDESSPASIELQVISNHDNLRAKADFDKTTQVFEIKVPRRVAWSSSDKAPCIQIRITVSAHRETILDHLNIETQQLDINLKEGVVLGVHNGVNIRSASGDITSPGIKTIKGKEVVPYTLSSREIRIHTASGDVKGWYPLYDLLDISTASGDIITNVGPKPVNPQNVRPAEFRVRSASGTIKIDEPLTSAQKAARPDREFPPRDYTVDIITASGDITADVAASSSASFKSQSGDMKLQIWPVLDSSLLTINEKAKPTIITDTKSGDTHVTILEPLWTSLATIGETIPPVKPYDPTDGSDPYIVLPEGSELAGISMARPVLSVLHSTHKSVSGKIELYYPNSWEGMFFANSISGSQEFKGKDVTVDRGRGSIPPHLISGRKGKGFSQLDIRTVSGDQFALLGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHN9</accession>
    <name>S0EHN9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_09270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436228.1">
        <property type="nucleotide sequence ID" value="XM_023568846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHN9"/>
    <dbReference type="STRING" id="1279085.S0EHN9"/>
    <dbReference type="GeneID" id="35402739"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09270"/>
    <dbReference type="HOGENOM" id="CLU_024992_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="620" mass="69568" checksum="E04EE2D3CEFCF585" modified="2013-09-18" version="1">MSQVSHGYKPARNNNTELELHQGTTAEPKGVPQRQGDAVSAGPQQAKSYGNQPFTSHSVTSGLPRSLFNQLGHVPAQRIAPASPNIQLHTARASLVQEIGPEDGAATLPQLHDGQNHIAENERLSKLVDRMLLAKIRDLMMDAIKGIDKSVTDIWTSPLWPVPFRFHFGPDPDDMVELSQCSLRESTKATLIEQAFRDAWPKNGDWLKALVVESDGHGPAVLVPWSSVGMAYQDDLKFEYDHRISNRGLTITLQTVTFAYEGLWHSWCYAARGTREQREQMGENNDTRQPSSTPTSEEGPIEGYTCREGKCVLSKRQYTTIRHDSEEICLGERRARASSLYCPCVMIGCLYAKGTFKASVMSWKIGNVMASKVLEYCMDAWGEALEAIDRLAHVNLEDLNGRSRVEYLMFDQSFDRSKDYFVALQLLRIVDEWLDEIVPSLKELRMKPGLTHTEAEENLDAAIRFMTGRAGAVQNRVRRKVEQINSLRDGLFSATSLRESTKAMALNQAIYVFTVVTVLFTPVSFLATFWALPFLNNPKEGSGVVSEPSAFRNSFIVMPLLTYALVIGVAWAVGKRNSGRALLDLLREYWGKSWSLMRSAWTSRPQLPWRYRGSSPYPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHP7</accession>
    <name>S0EHP7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436387.1">
        <property type="nucleotide sequence ID" value="XM_023569129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHP7"/>
    <dbReference type="GeneID" id="35403821"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10356"/>
    <dbReference type="HOGENOM" id="CLU_034857_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="63743" checksum="FA1E3E64C1441315" modified="2013-09-18" version="1">MASDDSRLVTEIWDNICSFLTPPTLSNLRLTSHRLNDIARPWKYRSFRLEAFAPSSVERFIQIAKIPELRSLVREITIDTRIDFDFEYLCNDSFNFPIAFMNALPHLRFFTNVTALHIRFEEHCGEDDRYYQSIEETFEFRYRVLDTILHCASGLWTLEKQIKIDEVMEGYLYFEDDEQLDYSDQDLEFTHDKPFPLKELTITHLADYDDPNLNVSEAWKRIISLPSLVDLRLFVTTEECDASPESTIHYVEKYDFFGNLHNSWLSPNITDHLRVLSLYFKDYWGWFPIMDFRNIGEDSPFPQLKVLTLGNYVFTHEWQIEWFAKLGKENGSRGLVELYLDDCPILYHARQLRIGNDGYADHTAHTAQGGTGRGWNPIKRDFPIRWHQILSQWRDSMKGLKTLRVGHGCWWDCPKDTRQAILEDSDYKDIDLQAMDHRLTRNQHRDFACPAPTDEEYWDRENTWVSEKHRYGTGIDDQRTSRMQYIEYNCGLGPSPWLEKNSRYDCDEEGFAPEKGTLEKDNAAWDMIMAATRARRQGLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHV1</accession>
    <name>S0EHV1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_10617</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436639.1">
        <property type="nucleotide sequence ID" value="XM_023569422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHV1"/>
    <dbReference type="GeneID" id="35404081"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10617"/>
    <dbReference type="HOGENOM" id="CLU_024566_8_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT74561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="333" mass="35459" checksum="EAB6730D965C9613" modified="2013-09-18" version="1">MPSPQHESELSPRESRIIGALLGVHAGDSLGATLEFKTHTDIAREYPLGLRDIVGGGPFRWSQGHATDDTDMTRGVLLAYHDYKAGDDIAQLAGDYFISWLHGDWPGRRPGSRPEDIGGATATGLRRYKQTQDPDRAGAGQGSAGNGSLMRCIPTGLFQRDPQKLVDESIRISKITHDDKRCTVACAAYNTIVSKLINQVDPQDAVKAGLNVAETLEGGSGPVYKAIELGKSLSIATMAKKGPVPELGGRCSGYVLESLSLAIAAVLDTRSLEDVVVDVVRIGWDTDTNGAIAGGILGARDGAAAIPPHWKSVLQFGREFENTALSIFEKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI47</accession>
    <name>S0EI47_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein PTH11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_10743</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436759.1">
        <property type="nucleotide sequence ID" value="XM_023569561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI47"/>
    <dbReference type="STRING" id="1279085.S0EI47"/>
    <dbReference type="GeneID" id="35404207"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10743"/>
    <dbReference type="HOGENOM" id="CLU_019101_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT74681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="385" mass="42162" checksum="E1C2C65FAE4E75AF" modified="2013-09-18" version="1">MSDPVVEGWTLYAVGFASTILRFYARMRVDGLRSLQAEDYLMAISIAFYTIQTTLAYNIGILAHGLANNGMADAQRAALLSSDPEYDFRIIGSKIQVAGWTIYSALIWSLKLSMLYFYTRLTTGLGRPYRIRIYVGFGLVIGTFIATMIAIFAGCRPFHKYWQINPDPGNSCQPAISKPIVWVSFAANISTDIYLIAIPLPMLWGSSLKMIKKIASTIVLGAGIFVLVCATLKSVFVLVDPVHGAELAGSWGTREAFVAVMTTNLPILFPLFRVWLTPIFGSVLRSSHKTSYQYPSGFQTIGGGGRSGKSNDPSRRGPPTANPLSANLSFNNSEERIVKAEAHRMNDLTDYSASKGIIVSNVVEVIHEDKKGGSSRSREGSEGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJA6</accession>
    <name>S0EJA6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437149.1">
        <property type="nucleotide sequence ID" value="XM_023570018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJA6"/>
    <dbReference type="GeneID" id="35404616"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11152"/>
    <dbReference type="HOGENOM" id="CLU_1133291_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496104" evidence="1">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="220" mass="23373" checksum="0C147D357F756CAB" modified="2013-09-18" version="1">MFYTRFLTAVVAGLLGAQGALGVKHGEISEFDGKNVRWQELAKGVFTGVPENEWDDKLHKRSAVELDINEIVGNVTTSDGTQLESRDLAGTCRAGQKCVVKATTYVLLSGYNAWVSTAEYVSSGNLWEFLNKPFVANAGGVAIAGIISGQINEATKKECSTEPPDTSQADIIRTALEKVIDQNTEAGEVSIDISGPSGTVNIKIKAGPPNTSPNPECNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJY3</accession>
    <name>S0EJY3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437142.1">
        <property type="nucleotide sequence ID" value="XM_023570011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJY3"/>
    <dbReference type="STRING" id="1279085.S0EJY3"/>
    <dbReference type="GeneID" id="35404609"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11145"/>
    <dbReference type="HOGENOM" id="CLU_036199_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147:SF2">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147">
        <property type="entry name" value="PROTEIN TAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="289"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="506" mass="55863" checksum="71C2BB3F52383FD4" modified="2013-09-18" version="1">MAVSRNGSSNTAHVNMMTDSVIANLPPDGLRVIIRSLLASHPDITASFEDATRQYLAQAQTRTSKSQLAALDVGGLEKTQRIARCMLGSGQAFDGVSILERLVIRGVQIALDSPETEKQRVNSLLASLDGDLVQAMTAVTKKLAVSSGARALSPGEHDIIQALFESLAQCQRMLKDTGMDFPYGRGMLTTANILRIDLPESPEGRLNKIPSDITRPLPAKETFQLDDRILPRIFSGLWQMSSPAWGSAQMTEIIDGFSTHVQNGFTAFDMADHYGDAEVLYWDNPQYIDALQYLAEDKRVARIGLCNFDTEHLEHVVESGVKIFTNQVQVGTSAITDVAGPDKMQFSLVDSRPTFKMADACSRHDIKLLTYGTLCGGFIADKWLNEPEPDVYDTNITPSQRKYYGMICSWGGWDLFQELLSVLRTVATKHEVNISNIATRWVLDFPYVGAVIIGARIGMSEHTSDNATTLGWSLDDDDCGLIEEVLDRSNRAEMFETMGDCGNEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKK8</accession>
    <name>S0EKK8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435011.1">
        <property type="nucleotide sequence ID" value="XM_023582482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKK8"/>
    <dbReference type="STRING" id="1279085.S0EKK8"/>
    <dbReference type="GeneID" id="35406286"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12830"/>
    <dbReference type="HOGENOM" id="CLU_356400_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="522"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="591"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="624"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="787" mass="86652" checksum="39150C86E9C16A9D" modified="2013-09-18" version="1">MAEAIGLVASVASLLDLAFKLSNALHNLQFQLRNAPYLIQALENETEAVRTVLASVESSIHSTATAGLGGAGSPGILGDLTAEIGKGAAVLKELGTFIDSLKNETSTLRRVKWIQKKKKAAELINELKEVRYRISELQLAYGNSSLTRIRLVLQDIQVMQRRHYAKAHNLETCLLGTKDQLTIDRDTALQSQSDIAAALEALQNTTPTLPPEWVEAISNQVATTINTTQPGLAKENITTVLSHQPHRRQSPQAICSPLQHLTLSFNLRLVQPQCLINCACRCHASASSYRPWNGLPKLLRMIMGSALVEYCSYPVPRTTCDLHSCSKSRPTRLTVRYGFPFWSLKYAVHILMEKLSTSCLKFTLTLRRINPMKISGDNILFNISIGNLSVVRRIVFENPTAVLDIDVQGNSALHVSAWGFLPWELALQIWEVLLQAGADPDQVNEEGLSFRHRIANEQLQKNIPFKLQPEVQKLIQASQCLEDIELSFIHEVVVKRCPIDVGPILKSAKADILAQIHSEDRFGMTPLMYAVALGDAKAAQALIEAGASVHKKGPHGRNLVDYAGRLPPNTCATILHLLLAAGADAIDAFPTGWSLLHTAAIHNNVVMIDRLLQAGAQPDCIGPRGNRPIHYAASHNSVHAIRLLYEQGADINALADHRLSSLGVAIQKNATDAQATLLELGADHRITGDWGTYLHVAAYWGNERTFNTLSCLKFSGLDVDARDAEGMTVTEVYESRYDKTEELTISFCQLRDFITSRSPDDYSSKDEIGHTDEFFDAYEFLGGDGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL51</accession>
    <name>S0EL51_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436705.1">
        <property type="nucleotide sequence ID" value="XM_023569497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL51"/>
    <dbReference type="GeneID" id="35404149"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10685"/>
    <dbReference type="HOGENOM" id="CLU_1959769_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496190" evidence="1">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="128" mass="13997" checksum="770455ED269460B4" modified="2013-09-18" version="1">MHFITILTTAVATLASIAAAAPKTETFATASVYAFNRDQNTHKFVDVPFGKLTHIDYQITDLELRGVQFLLPDGEKIDPDKVTCQMYKDSLGTQPGSAAFTKKTPAHISLFNPVQFGWVLCYVNVGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL82</accession>
    <name>S0EL82_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436740.1">
        <property type="nucleotide sequence ID" value="XM_023569539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL82"/>
    <dbReference type="STRING" id="1279085.S0EL82"/>
    <dbReference type="GeneID" id="35404187"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10723"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="109"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="352" mass="38379" checksum="3D64BEEDDE0B7273" modified="2013-09-18" version="1">MTYPFPYSQAAKLDSRIKIPRPTYDHDLAPLLDSASFPEEFDLNLMRGVASGEQECSHGSFIFNAETVLSDNPHLSHTEHSVPGPDNNTITLSVFAPKNPSKAPRPVLYHIHGGGMVSGDRFTAVTSVIDLLRGIDCVVVSVEHRLAPETRAPGPAEDCYAGLVWISENASSLGIDPAAIVVFGVSGGGALAAATCLMARDRKRPAIPIKAQMLYSPLLDDRCESLADQQFEYGNPASTAWLRAIWDLILGDARGSEHVTPYQAPARETDLSNLPAAYIDAGECEVFRDVAVAYATEMWRGGSTCELHIWPGAWHGFDMMDDPKMPLIHIANMTKANWLQRVMKNTGDEKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELU2</accession>
    <name>S0ELU2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Probable type I polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_12066</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438054.1">
        <property type="nucleotide sequence ID" value="XM_023571035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0ELU2"/>
    <dbReference type="GeneID" id="35405526"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12066"/>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="7"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="965"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2508"/>
            <end position="2585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="965"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1128"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="444"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="997"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT76008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2591" mass="284678" checksum="E7987BDA01B42F56" modified="2013-09-18" version="1">MDEIRAPEPIAVIGLSCKFAGEATNADNLWQMIANGRDAWSQIPLSRFNWAGSFHPDHEKSSTMHVRAGYFINDDLGNFDAAFFNLSAETAASMDPQFRLQLESVYEALENAGQPIETIAGSDTSVYMGTFNHDYREGMIRDEDDLPRFMITGTGAAMASNRVSHFFDLRGASMTLDTGCSTSLVALHQAVSDLRSGNSTMAIVGSSNLMLNPDMFKALGSIGVLSPDGKSFSFDSRANGYGRGEGVATVIIKRWRDAVAAGDPIRAVIRETCLNQDGKTETITSPSSNAQEQLIRKCYKNALLDPLETQYFEAHGTGTPTGDPIELQAVAAVFQSRQSTEPLQIGSIKANIGHTEPVSGLASLIKVVMALEHGVLPPSINFEKPNAKLNLKEWNFEVPQKLEPWIPNSNGIRRASINNFGYGGTNAHVIVEMGPQWRTDSGIHATNGTSHINGHTNGTESTSVSDQKPTSEGNNTNFSRNKTKVLVLSARDERTCEHMISNLKYHLRRLKDHGKPDQLLQSIIYTLGHRRSMMPWVAACPISYTRGISTVVESLESSQFKPKRIVRTPRIGMVFTGQGAQWYAMGRELIIAYPVFRSSLELGDAYLRELGADWSLMEELMRDAPDTKVYDTAVSIPICAALQISLVNLLQSWGIKPAAVTSHSSGEIAAAYTAGVIDYRASMAIAHYRSVLSADKALRGSVKGGMVAVGVGPDHAATYLEELQSDGKASIACINSSKSVTVAGDLSAVLEVETRAKDDGVLASRLNVNIGYHSHQMEPISHRYRDALSRVKLFNSANNLESIIYASPVTGGRMTSAEEIASAEHWVASLVQPVQFLDAFTDMVLGGFDPSGTSVDVVVEVGPHSALRGPIRQILELPEFGGLQIPYYPCLIRKTDARDTMQALAANLIGEGLELQLDSLNFPYGRESFVNVLTDLPSYPWNHQTRHWVEPRFNRALRERDQEPHCLIGSLVLGTERDSPSWRHVLRVSESPWLRDHVVQSNVLYPGAGFICLAVAGVAQMVSMQVIKSVDKLGNDRQVSGYRLRDVEILRALLVPDIQPLELQTKLCPASDREIGLRGWYHFEILSVTGENRWNLHAKGSIKVEFADESTPGVGGLEAISPLIPSTARRIAPDDVFATFRSVGIEHGPAFQNFKTILQCQTEPRSKATIIVADTSANNTIIHPTTFDSVVQAAYTALPKAGYFQESPRVPRRFRQIWISSNIGHEAGHEFEACSRVNDAGAQSFEADVRLFDAQKDSHGSQTPVLEIQGLFLQSLGHAIGTGNKRPWENEVCNRVEWDIDMTVTDPRTFERIKKDLTLSDPGESFTKELRPICLYYIHEALAELSPPDVSSLSGHLAKFYGWMQDQVKLALPETKSDNTDETLDLRSLNPGLRLLLISQAITKSVAGEMICRLGPHLADILRGKTTPLEVMAHNNLLSRYYEESPGLKRCFRQLSQLLRKIVHKNPRARILEIGAGTGSVTRHALEVLGTRDSGGPLAELYHYTDISMGFFEAARKEFSGWSDVLAFDKLDIEQDPAEQGFKLGSYDIVIACQVLHATKSISHTMANVRSLMKPSSSLLLIETTQDQIDIQFIFGLLPGWWLSQEPTRQNSPSLSILSWDNALKTAGFTGVDMVVNESENASEYAFSTIMSHTKSEIDSSFEIRPEDIVLVTTSKSIPPQDWMVSLARSIGGKDDSFAVQLLDAPDATDSTYRGKICVFLAEVEDNVLFELNLTFLEGLKLVVANCRGLLWVTIGGAIKCEIPCSALATGFVRSLRNEYVGRRIMTLDLDPSPTTWSSAASDAISRVLKHSFRDTDDSNMFDGSAMDFEFAERDEAIMVPRYYKDTIRNELIMPQQNQQSPDNALTELFHQEHPVRLHVGTRGLLDTLTFVHDEVIMTADDSQILESFVEVEVRAYGLNFRDVMVAMGQLEDKIMGIECAGIITKVGAVAALHGHFVGEKVFALLRGPFASRVRTEHWNAVSIPEGTTFEEAASMPMVFTTAYVALFDVAHIQRGQSVLIHAAAGGVGQAAIQLAQHLGAEIYVTVGSPKKKQLIQQRYGIPDHHIFNSRDASFASGIRDITEGRGVDLVLNSLAGPLLQESFDLVAPFGHFVEIGRRDLEQNSFLEMRPFIRHISFSSLDVLHMTREKGPDVRRILTEIARLKQRNVIAPVDPLTSYPISDITKAFRLMQTGQHTGKIVVSTGPLQKVEVQPYPKDIKLSPEASYLLVGGLGGIGQCLASWLVNLGAKQIILMSRSAGTKDEDAVFIRDLAETGCRIECISCDVSKSHDLERALQLCTAKGLPPIRGVIHAAMVLQDSILEQMTIENFRAAVVPKVHGSWNLHTKFQNVDFFIMLSSINGIVGYASQSNYSAGGSYQDALAHWRVTVGLPAVSLDLCAVKTVGYVAETAGVAVRMQRAGHMLLREDQLLGLLESAILHPFTPQIVAGLNTGPGSHWNRDGESQLGRDARFSALQYRQPREQRARDGDMAHKNSLAASLAEATSRADAEAIVFEAIAQKLSSIFVIAVGEIEPSKHPSHYGVDSLVAVELRNMISLQAAADVSIFSILQSQSLGALASEIVDKSRYTEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMX3</accession>
    <name>S0EMX3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437340.1">
        <property type="nucleotide sequence ID" value="XM_023570192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMX3"/>
    <dbReference type="GeneID" id="35404771"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11309"/>
    <dbReference type="HOGENOM" id="CLU_1294503_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485796" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="130"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="213" mass="22767" checksum="035CFC47407C0309" modified="2013-09-18" version="1">MHYSAFITAALSAVSVAAAPNNKLPCRSLDQCSLVNIPSKSLCGLTGYRQNPDAKSYDSVHNFQLTLDGCIKACGTTKPDCKSVTYDDVNGICYFSKYDLKTINVKSQATGYKFYDAGCGFAASAGGAICGRKGWRQNSAATSYDSVHNNKLDLKNCVAACGTTKPDCKTVAYDSVNGICYFFKYDATTINPADAGSGFAWYDARCLDCPASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMY3</accession>
    <name>S0EMY3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438237.1">
        <property type="nucleotide sequence ID" value="XM_023571182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMY3"/>
    <dbReference type="GeneID" id="35407628"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14176"/>
    <dbReference type="HOGENOM" id="CLU_1602856_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="166" mass="18616" checksum="7CC25398753015A4" modified="2013-09-18" version="1">MLRRPKYMPSSVMSRTTATHPKLRCKPAKDSIHLGTENPNIIEPDTPAGPARGACNSHRSYNNGLINPKRGHIARRRVDTPDNAFWTKLVVSLRKTEGSRTCQREPRPAHPYLRPASHQLKCLSQVAFRNCSRFMALRLCLSSSTRLMATHAWNCNAGATARPALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN39</accession>
    <name>S0EN39_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438322.1">
        <property type="nucleotide sequence ID" value="XM_023571153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN39"/>
    <dbReference type="GeneID" id="35407655"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14203"/>
    <dbReference type="HOGENOM" id="CLU_959920_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT76276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="290" mass="32268" checksum="CDD899D5FF120845" modified="2013-09-18" version="1">MAPKRKATYSTKGKGQATRGQGTGSSRDTEGNVNRLPDPGTDSDEFEPEAHTTSDSDGESIHEATATTETGKLRAIPCIPCLKRMIKVPSNGRPEPCLLRKGGNFTACKACAEKGLGCKGLGEYVDQPLEQWDDHKRDEFVISFTNLAMRVRRAAQQILKNQEVGEDWEKLTQKVQKYVDKVEAEKAKQEAHKQKAKYDKLREELEEAKAELKSIRDWIDASPKLFVPKSVSDEWFVRFAAGAKLLGEMYPEELQERVNEIREDLEAGDAGTDDGDAADEEDDDGGMMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENZ3</accession>
    <name>S0ENZ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to gibberellin 20-oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_12080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438065.1">
        <property type="nucleotide sequence ID" value="XM_023571052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENZ3"/>
    <dbReference type="STRING" id="1279085.S0ENZ3"/>
    <dbReference type="GeneID" id="35405540"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12080"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="172"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT76019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="357" mass="39948" checksum="48DB18B964341C99" modified="2013-09-18" version="1">MASKETASLPVIDFAKIIGPSISRSPGVLEDSIKEKQKLFDAFVNVGFVYLANHSIPDFARENLFSHAKKFFALPVSEKAKVETGESKGFHGWFSPARTSGDSRHSDLKEAFDVGKENDPTRPNQWPENWPEFRDDMNFFFEKCHEVHLVLLRVLAEQVGVDGGFFEPHVDEKDHFFRVIYYPETTRAAFKERTRASAHTDYGTLTLLFNDESGGLQVRRADGKYIDAPPIPGCAIINVGDLLSRWFNDILISTEHRVVEPVPKPDADGNIPDIIPARYSIAWFGHPNREALVEPIKACCTASNPQKYGAVYAGKHVVERLAYLHKNGQNTTTWTDDMQRETSEAVANAPLLQAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP20</accession>
    <name>S0EP20_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to Y.lipolytica GPR1 protein and Fun34p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_10624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436646.1">
        <property type="nucleotide sequence ID" value="XM_023569429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP20"/>
    <dbReference type="GeneID" id="35404088"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10624"/>
    <dbReference type="HOGENOM" id="CLU_051062_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF7">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT74568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="230" mass="24530" checksum="5282656BFA7FB4A8" modified="2013-09-18" version="1">MTTKSIEEIRSHSPSPSAPGLGQCIGNPSPLAMGTFATTLLTLSLSMMGFRGVETQTIFIGNLCFAAGLCMFVSAQWEMARGNTFGYSALSAYAVFYGGYGVILCPSLGVLDSYGGPTPEYHNALGFYVLIWAVLTLFFMLGSAPINLVSFGIFTTIFFCFTLDAASNFAHADGKVEVAKNLMKAAGVFGFVSGLLGYYSCAAAMCADALPFELPCGDTSRFFKKTRKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP57</accession>
    <name>S0EP57_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to aerobactin siderophore biosynthesis protein iucB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436751.1">
        <property type="nucleotide sequence ID" value="XM_023569551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP57"/>
    <dbReference type="STRING" id="1279085.S0EP57"/>
    <dbReference type="GeneID" id="35404198"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10734"/>
    <dbReference type="HOGENOM" id="CLU_039848_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF7">
        <property type="entry name" value="ACYLTRANSFERASE MBTK_IUCB-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="2">
        <location>
            <begin position="239"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="428" mass="49732" checksum="209A940EF58601EF" modified="2013-09-18" version="1">MSSEPFQQKSPIKIRLPLPYLSTYYLERTAEGKQSYRLRKDDSITEGKPFPKVLHADDLVFSKIPAVESDKIPDSDNREYARARRSPVWSLSWEKQAPTLSQTWMFLYTFFTYHFDVEQFRLRLEGAGAEDLAKELVLSMVAINMPPPPKGVEPAPSTGLEVLVLRSAFWQGCASPLGQQPIWLPTWNSANVVPHLEYVMTPTSESTLLRHPRRTPKPAAGSYIYSRYIPSLDEHFNLVALDYENPEHLGLFNTWQNDPRVAAGWMETGTLDEHRTYLKNIHDDPHQFAVLGYFNDTPFAYFELYWAKEDKMGQHYACLDFDRGRHSLVGNDKFRGQYRVMAWWPSVMHYEFLDDHRTENVVGEPRLSSENVLKYEMIFGLHQDKWMDLPHKRSNLVKISRERFFQICPFNQGKPRVAGTTFGFEPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPQ9</accession>
    <name>S0EPQ9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437626.1">
        <property type="nucleotide sequence ID" value="XM_023570525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPQ9"/>
    <dbReference type="GeneID" id="35405069"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11608"/>
    <dbReference type="HOGENOM" id="CLU_1023262_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="272" mass="29408" checksum="CC77446CAB033A72" modified="2013-09-18" version="1">MLAQAGLGGLQFAQAIPAMQANAVFAAAGGPFQDLVRRLEVFKQKVAMQDAFLRSGVKENLSKSINRLEVALLQLYKLAVFIRGAPGGDGMQKMMILVSALEPFQTVKLPLRLVSIRVNAAQDQLQNSHRALMQVVNQQNELNTRRAAIEQVAQQLPVLQATADALNKQSAALLAGFTELREKATQLALVMNDMRNGARGTGAQSWDKDRFAEGILRLCQMALIDGRVCDEVETITTEISSGYSGQLPGSVADLLTKVGQFARDVAQKSISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHT5</accession>
    <name>S0DHT5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423612.1">
        <property type="nucleotide sequence ID" value="XM_023567752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHT5"/>
    <dbReference type="GeneID" id="35395473"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01990"/>
    <dbReference type="HOGENOM" id="CLU_144283_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13724" checksum="09D0C847CA410447" modified="2013-09-18" version="1">MSHPIIFNGSLGLGLMIVGLGLNATLRPNDHLQRLEFPIPTEPLAKKFSLALMRIWGIRNITVGVLISIIWTTGDENLMAKALSAALAMPITDGFVSRIIIGGGETQHWVFPPLLVVMIVGLFGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHT8</accession>
    <name>S0DHT8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423691.1">
        <property type="nucleotide sequence ID" value="XM_023573550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHT8"/>
    <dbReference type="STRING" id="1279085.S0DHT8"/>
    <dbReference type="GeneID" id="35395384"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01901"/>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF53">
        <property type="entry name" value="BETA-1,4-GLUCOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484610" evidence="2">
        <location>
            <begin position="19"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="623" mass="70254" checksum="69C755987AAEFC80" modified="2013-09-18" version="1">MTPSHAVIQFLFASLAVGQQIYLDAKGPTERPQCKATSTKTHEPKYTHTPFSYTLSETVRYATSVPSPTTTTTYANPPESLISLVPSLSFTTWGKWDPNATTKASDTEDPYGRAAWTALWEHANPPNFTETGIFSTTVSPTPIPTSELVLPPRDYFGPSDCYNFPKNFSFGVASSASQIEGATAEEGKAPSLMDILVQDGRVKDYVTNEHYYYYKQDIERVAAMGAKHFSFSIAWTRILPFALPGTPVNQEGIDHYNDVINFILEKGMTPEVTLLHFDTPLQFFGSNLTKAADRPEIGYVNGGYQNETFQDAFVHYAKVAMAHYADRVPVWFTFNEPLLYSYNALSINNVVKAHARVYHWYKEELGGKGKIAPKFNNNFGVPRDPKSEADVYAADHFNSIQLGPFCNPIYLGEDYPESFKKTFDDFVPLSEDDLKYIGGTADFLGIDPYTATVIAPPVPDEKDSILECASNSSSTFRPYCVNQTTTTVNGWNIGYRSQSYVYITPTYLRSYLNYLHNTWKTPVALTEFGFPVYGEAEKDLSDQLFDTPRSIYYLSFLSETLKAIWEDGVEVVGAYAWSFADNWEFGDYDQHFGIQTVNRTTQERRYKKSFFDMVDFMKARGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHV9</accession>
    <name>S0DHV9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Replicase polyprotein 1a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423945.1">
        <property type="nucleotide sequence ID" value="XM_023576451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHV9"/>
    <dbReference type="STRING" id="1279085.S0DHV9"/>
    <dbReference type="GeneID" id="35395126"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01641"/>
    <dbReference type="HOGENOM" id="CLU_045844_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40169" checksum="D28524E79A18B16B" modified="2013-09-18" version="1">MFTTLPDFTPRDSHSLWYRSSRSPYTPPGPLDDFSGDTHNIQHGANQARQRTKLIERSALARLAADEQYMQRRRLNVQNYGSGWLKPPGVPKTLHQMREEKREQEEHQEAMRREQLAQELAEAEAEGMPGEGTMDDVQLDGAQDLDDEIPDADEEGYAFGDEDEDDDEEDEEEDEDEEDGEETDDEALRAERQNDLMQARMRMGDDAFREALVRGEPDANDMYGDTEELEEEEDNGHLLDEEDFAQDDDLGMDMDADLDEDIPEAESGGYEHTDSEAEISSSEQESSSDDEDDDEDDVDVSFAPRSATLPRPMSPTFQGRSSMAHPRASMDLSNLLSQDGSSFMQSSPAGRRARHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIP5</accession>
    <name>S0DIP5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424196.1">
        <property type="nucleotide sequence ID" value="XM_023579550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIP5"/>
    <dbReference type="STRING" id="1279085.S0DIP5"/>
    <dbReference type="GeneID" id="35394849"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01364"/>
    <dbReference type="HOGENOM" id="CLU_024655_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="453" mass="50189" checksum="9654F4FD1C519992" modified="2013-09-18" version="1">MDSLGSLAARKMDRSAASRQKSCNACVRGKRKCDKKTPRCTRCAAKGLDCVYQRLPPGANFHDDDLCAGLDATENLNEVPDFDMGFDINNLGVDSSASASTSNTTPDSLDRVTTSSIELDSPLDFSIIDHLMANDTSLGSELWNMGDYGNNKLGIPPVPAGPVVIRDVALLDRADACLADFNPLDVYDPRTRVGYTVDIITNLYRDFARTRRLPFIHPRLYGSNLPKTMLAAFSAASAYSARTAENKGWVYKLITDMAKEIHREGERASTPAEKLARVQALVVLDSIRMFDGDVTLRATSEREMSQFIAWMFALKEVEEELSVGDEPGATTMKGPPPPSWESWLLAESIRRTTVMSFAFVCMTSILKSLEPPCGIMEGPSFQFTASRYLWEADSSIAFYRAWQTKPQYPVRNLDFKGVWLHAQPEDVDEFTKLMLTAQMGPEAIDQFMMGAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKW9</accession>
    <name>S0DKW9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to 5^ nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425112.1">
        <property type="nucleotide sequence ID" value="XM_023573381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKW9"/>
    <dbReference type="STRING" id="1279085.S0DKW9"/>
    <dbReference type="GeneID" id="35393844"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00359"/>
    <dbReference type="HOGENOM" id="CLU_019028_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07407">
        <property type="entry name" value="MPP_YHR202W_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000043">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000008">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000009">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041823">
        <property type="entry name" value="YHR202W_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF43">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY (AFU_ORTHOLOGUE AFUA_3G04160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484671" evidence="1">
        <location>
            <begin position="21"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="365"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="608" mass="68555" checksum="25CE785C063B30B1" modified="2013-09-18" version="1">MILRSKTLAAGSALVAVACASQPGAIEPIPGPMRDLTWGQLNFIHTTDTHGWIGGHFQEPQYSADWGDYISFTKHMRKQADEQGSDLLVIDTGDRIEGNGLYDASSPKGLFQYDIYAEADIDILCTGNHELYKAYSADKEHNTTVPNYKGKYLASNLDYIDFKTGDRVPQAQRYKKFKTKNQGLEIVAFGFLFDFTGNANNTVVQPVEDTIKEAWFQEAIREKPDLFVVIGHVGLRMEEFKVIFTAIRKQNWHIPIAFFGGHAHVRDAVQYDSKAFAIASGRYFETIGWMSIDGISKGSTKEVEASASPTFTRRYIDNNLYGLHYHTGLNESTFPTADGKRVTQMITRARKALQLDYKFGCAPKTLWMTRTKHTDEDSIYYWISNQLLPDIITRKDRKDKARLAIFNTGGIRFDIFKGGFTRDSTYAVSPFTSGFSYIPDVPYKAASKVIDLLNSAGRILSENGADVKFLAMPEQAFPAPAMKAMFEANKEDEDEKRLELRSFLDKPDLTSGYTTKDDIGTDGDDTIHEPLKFYEQPNCIQAEINMPSKGDPETVDFVFLDFIQPWIIPALKFAGAGDYSDADVQRYIDGTFTYHMAQWISKNWQGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL66</accession>
    <name>S0DL66_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable ribosomal protein S14, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425232.1">
        <property type="nucleotide sequence ID" value="XM_023573527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL66"/>
    <dbReference type="SMR" id="S0DL66"/>
    <dbReference type="STRING" id="1279085.S0DL66"/>
    <dbReference type="GeneID" id="35393712"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00227"/>
    <dbReference type="HOGENOM" id="CLU_139869_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="113" mass="13261" checksum="0D3552E822CE7F31" modified="2013-09-18" version="1">MSMFRAKKLDLGCFVNVRTLRDHTKRKVFEAHETERQALRYIIRNTTLPPRVRAEAQLQLTQMHCYTRPTQIRNRCIMGGQGRGVLSDFKMTRYNFRMEAMAGNLPGVKRASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL76</accession>
    <name>S0DL76_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425242.1">
        <property type="nucleotide sequence ID" value="XM_023573538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL76"/>
    <dbReference type="GeneID" id="35393702"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00217"/>
    <dbReference type="HOGENOM" id="CLU_2263807_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="113" mass="12935" checksum="12880C55A35EA1B9" modified="2013-09-18" version="1">MAAAQSGDQNVYIMTQEGDDFIPETAKWTCKSGPTESQCGHVNKDIRNKICERCHKRRSNAVAHVGERLDEGVKGRCWEIRGVTAYGAEIWTYEFGRKKNEFWARFDSHPNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLH3</accession>
    <name>S0DLH3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_00278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425545.1">
        <property type="nucleotide sequence ID" value="XM_023573471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLH3"/>
    <dbReference type="STRING" id="1279085.S0DLH3"/>
    <dbReference type="GeneID" id="35393763"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00278"/>
    <dbReference type="HOGENOM" id="CLU_035620_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="190"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="421" mass="47294" checksum="2F8D39006BD46E4E" modified="2013-09-18" version="1">MNPVPPPTTLHDARRQIRIRHLEQLSHANITLTSPEDDEETSILPSCKIFRAELKKWSQDHMKSIQEAISKNVLSGKENIDWNCCFLAFMESMTVYLRDWDKLHDAVQLYKSVKAGTSPNGDLHQVHDLYEQSVEGIKEVAAVWGMDFMQICDLTKAHQGHSDKNPKWNGPFCGAFFPKDHEQGAPYVGITFKGTDPKNIKDINVDSSFDPIQVDAKHLFGTVVSEGVYNALFGTFNKDSVSPFELILKALQDFVPKLNVEDNTEPLLHVTGHSLGGSYSSFCFAQLMMQNASLPAGARLGDLYNFGSPRVGQKAWSQAFYENLCGNFPGGAWKIVNDKDIVPQVPSLLKYKPKTGPFYHIDNGIQIFKEAKPAPIETERNGPGNVDIGFTRFGFVRRLATQTYHYLPSYYHAMEYALANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLU4</accession>
    <name>S0DLU4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423589.1">
        <property type="nucleotide sequence ID" value="XM_023579894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLU4"/>
    <dbReference type="STRING" id="1279085.S0DLU4"/>
    <dbReference type="GeneID" id="35395496"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02013"/>
    <dbReference type="HOGENOM" id="CLU_010595_9_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31804" checksum="C2DD0C1B810C005E" modified="2013-09-18" version="1">MPSIYTLNHGDAGRERQRLDLQHDVFKDITRGDLPPVIWQHLKSVSAPKVADANTGTGIFLKELAARVTEEAQLDGFDIDTRKFHETTSLPANVKLQYGNVLEPFPKQYLGIYDLVHVKLLYAALKKNEWLQAVKNLKTLLKPDGYLFWSEIGAYGYASNPYSAALHEWKRIESAAAVKFGRDPKCPVLLQSQFREADLQQVDEKVFVMLGRPDLTPVITRVALEYMAQSLHGILLVDRDESLGLTESGIESLVETLTKETEDGVEVGTNLHWVWGQNNGMPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLW8</accession>
    <name>S0DLW8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425680.1">
        <property type="nucleotide sequence ID" value="XM_023571362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLW8"/>
    <dbReference type="GeneID" id="35398735"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05254"/>
    <dbReference type="HOGENOM" id="CLU_058260_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="478" mass="53774" checksum="7ABA49E1BB8ED25C" modified="2013-09-18" version="1">MAENSSTPIADLVNKVKDGSINLSELTVQNCPQLPHDDITAKELEKVYARMVDEVFKMAGFNKVDAITCFDKCVERLARGKPFSASTIGDYKGWKAVRKYVDLAVKLHRETLEAVCIPAPQLISMIVLLNIRQVRIGTDRFLSQNPLFFRLFGRYNISQWLPLAIKFYRRLRNDIFIIENDGSLGEPQIRKKTISKNEVWIVSANLSVDNPRILPTPLVDRITLLEPMINEDVAMSGLNDSSMSESGDSDSSELVTLALTTTRAEAIQKAGDLLQKLDQTGIDQASLKPQLDGWLSEPHIRVMPEEVKNELYFWCAIHSPSWCALIHSCLHDDRETWDYETSVPVGCELHTPAAGGSSFLRNLGRLAKKALRLSGSNPGEARQIMSRHRDGLKLFSLHYESDVRTDKRLKKIEDDVARIATAVEQITTSRHNSKADITEVWSLCLQHQGNIPECVRRLAASNLTAEEMQELEARQVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM65</accession>
    <name>S0DM65_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to mei2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423714.1">
        <property type="nucleotide sequence ID" value="XM_023573206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM65"/>
    <dbReference type="STRING" id="1279085.S0DM65"/>
    <dbReference type="GeneID" id="35395415"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01932"/>
    <dbReference type="HOGENOM" id="CLU_674464_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="408" mass="44977" checksum="F789C76CD6238610" modified="2013-09-18" version="1">MLEAEHYRPKLFYTIHSDDPNLIGKEETFLGPDNQSKMKRSVENAEHVGLFTPTAGQYFRDERRRRHSQYYGGLAQGSTLSATASSFEPLGQRFKGKNALVFYPEGGGAPSQDMDISHRIEGCDTPAPSIAELGNYITVQAWTMFRIDLPTLRITFLNTFPDTLGDFSSPTYWVTGRPKRAAPTNLRGSEARGRTSCFETSRTRTANLLRRKLLAPLSGGPIACFDSGWPELFGDFVVSRSDPRRKAGECRPWFSGPPRGAPGAGPARGTEHRIERSMDVMVAARRSMYGADMLPRTTNFGVTPEEARELNKKQHGSVLKLICLGLPGGCMMLSPFLWAVRFYVIVGEAEHIIYVIFSNTTNFGVTPEEARELHQSQKAYDGAKATAAPDGGGIWDGGASKDDPSNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN01</accession>
    <name>S0DN01_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to cell division control protein CDC36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_05019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425901.1">
        <property type="nucleotide sequence ID" value="XM_023571625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN01"/>
    <dbReference type="STRING" id="1279085.S0DN01"/>
    <dbReference type="GeneID" id="35398500"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05019"/>
    <dbReference type="HOGENOM" id="CLU_032319_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="334"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT63820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="465" mass="50357" checksum="3356955D80818E00" modified="2013-09-18" version="1">MPGGFGGQQQPQQPGRAGTNRLPNGKLGNNNSGWAFGGVPMAGTGPQNAARQLGGNVSFAQSLSGSQPATSLDLSEFPSLSNNAQMSNPNQSSMWSTAGSRNLGGPSPRNQATPQQGGQDDMFSPTSSRGQGGFRFGNQGNIGQQTQSSSVDDFPPLNQTSNGEMGSDRTASLMSSLGFSSQATGAGPSVSNRGNGLLNALSATSRANEARSPPGIGAPGSSRPQDGKPPGLEEPRQKSSKEDALPDDASNVADYNNADYSATNYVAQTMQKRLDTENVIDPLEGMPASDKWGLKGLTTLMNNYPDYHAMVVGMDPNSLGLDINSQELFSTQIYSLFDDAPPRPVLSNGRFRLPDCYNVTNVQPIESKIQSFNEETLFWIFYSCTADVKQQMAAVELHSRNWRWHKKLQMWLTKDEHMTPQILSPTHERGYYVVWDTNSWRKERKELTLYYGELDTTLGQAQVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>S0DN55</accession>
    <name>S0DN55_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_04962</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425952.1">
        <property type="nucleotide sequence ID" value="XM_023571689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DN55"/>
    <dbReference type="STRING" id="1279085.S0DN55"/>
    <dbReference type="GeneID" id="35398443"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04962"/>
    <dbReference type="HOGENOM" id="CLU_027359_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="348"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT63871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="475" mass="53272" checksum="9E2E31BF33632E00" modified="2013-09-18" version="1">MATATAAGKNAQPFPDGTKDYVPLRAGGAKKDANKVHIADTPMTWSNWPQHINWLNTTLVIFVPLAGFISAYWVPLQLKTALWAVFYYVHTGLGITAGYHRLWSHSAYKGTTPLKIYLAAVGAGAVQGSIRWWSYGHRVHHRYTDTDKDPYSVRKGLMYSHMGWMILKQNPKRQGRTDITDLNEDAVVVWQHKNYIKCVLFMALGFPALVAGLGWGDWWGGLVYAGILRVCFVQQATFCVNSLAHWLGDQPFDDRNSPRDHVITALVTLGEGYHNFHHEFPSDYRNAIEWWQYDPTKWSIWCWKQLGLAYELKEFRANEIEKGRVQQLQKKLDQKRATLDWGIPLEQLPVVDWDDFVAQAKAGKGLVAIAGVIHDVTDFIKDHPGGKALINSAIGKDATAIFNGGVYLHSNAAHNLLSTMRVGVLRGGCEVEIWKRAQFENKDITYMNDSAGQRIIRAGSQVTKIVQPAASADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DND8</accession>
    <name>S0DND8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT64094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023571956.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="35398204"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04723"/>
    <dbReference type="HOGENOM" id="CLU_004484_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="979"/>
            <end position="1161"/>
        </location>
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            <end position="38"/>
        </location>
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            <end position="80"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="258"/>
            <end position="273"/>
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    </feature>
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        <location>
            <begin position="979"/>
            <end position="996"/>
        </location>
    </feature>
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        <location>
            <begin position="1009"/>
            <end position="1020"/>
        </location>
    </feature>
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            <begin position="1075"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT64094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1481" mass="165359" checksum="3B73BF10F9DC2888" modified="2013-09-18" version="1">MSGYPNYGMLPEDENQSQNGNQDQNPGQYHNGNNSIQRFQCDPNLINATFGPGEPSFDQSAGSATWEQQTPIPQGQQANQPNPPVQEEWNFETQSPYKVAKQTLKKIFIQPFPDPQAEARAWSWTWALTQLHNLAMAHKAMLAQGKFDHCTVLGAPEPFTFENPRSAGGNPQVPIPSQQHEPRSIAGHRNVVNARADHGIVPPGLPAPPFSQPSLAGPSTGGHKKRGRAASPDTTAPAPKRTRNLSPNASGAEGSDANSSGIPNPTPNTTSPPSRQPHITRKRKAATDRGGDDGEDDLLLDPRPQKKPRGEPAASENRSNSRSNTKKGDRERVVQGTKCLFCDKHPEISAVKPCDWEQVSQSNGPKIYNLECTNCADYRSRNKDNTELAEKGGHKCQVPGPEKSLIHFEHKRYGVDDPQTYEDKSCSRCKRKGWEATCDADTILGYSCLICRRDEECRVGEEAMPFKRPNKLTRRPWYRHPCDRCLLRHKADGKLKEADCCSWIKDREEWENNQACRQCQRDGTICLDLGAPMGSFSERAENEPTSWEIRTEFEADKEKTKGDKTKKEKWHEYTEVLPHTTWRKPCQGCQTAGKATDCLVMWFQPDHACERCTQIGIDCMVPENGGLRHCPIFDLSRVGFGQFTPYQACEQCLKAGRNCDRQRPCDSCIRHNARCDAFHWAKPGCIDRGKIAKKKNKKTYNPGPLYYLALGYGPEGVNDLKDGRSIEHWIGPTAPVYGLIDPKDGPQLYKSVANAHQSCRPPVGIRPPAPLQSGMELKERPAEFWRELMNKCWLNSQPQPPKNYPQAYQEVWSLLRSLQDFQMAQVRMEPNLPVPFVRSFRGGPVLADIERTQSHIPSAAYQNPDAAQSQGVPQLPPNQPSMQYGDTYNPQQNAPEPQAPPYPFPAGYQPGGYTDLLSQTHGDPAAAGQEEDGGISQQQLPPVQPFPGPEQIHDSFDQQTFSQAQNGQQMQQDQGLLNLQGYGNSDQQQSDPYSQQMGPHQGPVDPEEDRQRRENLEWEKILGLLSSTAPQNADDESGERRPLAKSAIPAPVIENDQQERHSGSQSPEESNESLEVFKRRYGHFVDRSGEQAHGRSRANRGERWHKPQTSRGNKGSSQERTARGRRAPKNANDQVAFNPFLGFTFGPNQKPQSKEKPKSSRWKIFNHLEGIDMSEWHESKSKDPEEESRPRLFSIANGQTNQPTPLRDVLGDVPCEEKVTRTTLYCGEPGEGGWGLCNAWNTDSKGQAICQSHAHRNTALPYFPVCNDCTRGNVKYLFQHEHNPITQGELLSMRAYLCNDCAGQMSSGAPNAVQNQIVGTRRVYGTAVDEAHSQSIPSQAAANPMRNTEALTGCSCANRMLGTSLCQFHRLYYAEEVMKHAALMQEWRLSRFKKAVCPSCLAQKPSEKVNISANVDGFVRGAPTAWACVVCNDWLVNEHNDVNNQPKAIDKPLWNLNIGRKLLDPRRKITTGRVLGQVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP49</accession>
    <name>S0DP49_GIBF5</name>
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        <submittedName>
            <fullName evidence="7">Related to papaya ringspot virus polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023582472.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DP49"/>
    <dbReference type="GeneID" id="35394588"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01103"/>
    <dbReference type="HOGENOM" id="CLU_000327_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="903"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="5">
        <location>
            <begin position="1715"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="2214"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="6">
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            <begin position="2288"/>
            <end position="2629"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
            <begin position="2438"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2592"/>
            <end position="2642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="954"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2444"/>
            <end position="2464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2592"/>
            <end position="2602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2612"/>
            <end position="2628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2629"/>
            <end position="2642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2642" mass="297402" checksum="7682BF7BEB48A6D7" modified="2013-09-18" version="1">MPSNSSGRITKARKNKNSTPHQKNHRWESFTTKISKFNSLQPLRKVRRHDLDTEDLSTTTSYFQTGLQKWGELNVSKPFSAFKTKVWPLCESLPQLLHFEQRIMDLLADFIAGQDKEALEPLLDLLTAFSHDLGVRFEKHYGRSLDLIVAIAAKPQDADVIEWTFGALAFLFKYLSKLLVPDLRPTFNVMAPLLGKSRHPPHIARFAAEALSFLVKKAAAPSHRETALKRLVECARDDLLSIKDDRQFTLYKDGLMNMFAEAIKGTDNIIHSTGPAVFAALVDAIPEEERTLTEDTTWTDVVCGVLTSVIHHATADTFGDFATGVHQTIRANMERLSPADRQWQAVPLFRIYGTMAGVRKGNRLTDWAPLIKNFVELLSEVTKAGLEVPHDAASAVWKFVIVNIAIVWHHAPIDALIPYIVRLTQSLSREPFMKWFIPFCSYFCELDARRFGSLFRNDFQRFITNHWSEEPNEDMICILLPKMIENRAFPPAGEKDSCRMPQGWQDQIVSKFERLEISPFPERGPYNKDPQVWRDRCLPRYSALLQILELTAVHPSTNARIAELLLRKLKLALRPSSTLASDEVHFIVGQGFHAYLRMSKAAGSVDITLSPLLRAAVPRFSQSVSFLHAYLAYEEILQSKEIARRQDSTSSDSSSTEEDPVTRSLIENLSSPSHELRLASLNLLKALSPTPDNWNAVETMIETEETPLSLAHTRTIAMHLRKLGQNYASFEEGSWLQRAVPAFLFGMLTVKLSPVWDDSVETMKQITQTKAGEEAICEVAFRWLKIPSARWGPSQPETQSSRPAFVSDFECTNVRRLEEVAADVENIIDRPDEFMLQNFDDKQQTAETVAGNSRSRALKVFNAIPSIAERRSRLLVPHFLAWASEDRITDSANDQDVSEGATWSLADRKAMLSVFSQFINPRVLYQHEDVYTALMQLMENGDVEVQKVTLKAILAWKQEAIKTYQENLEFLLDEARFKNELTVFLQDENAIKPEHRADLMPVLLRLLYGRTISKKGAASGRHGLQATRLAVLRNLSVEDMGSFLDIATGKLKDVKVVGASKTIFEEPILPIRKQVGFLNMISSVISELGTKATPYLDTLLNAVLYCLVFACRQLSTQGMGPESEEEEEKASTQSLLRVIRSTGLKCLIALFQNAQSFQWAPYQDIILEDVVAPRLENLPSETTQGISGMLQLFATWSVLPRIALFLAPHSKVPEGILPKVIECLSIEKGKDEVKIHVLTIIRNLIKLATAPAQESEFNEVIKADLLDTNAKTILSQISTVLDMSGISNDLMEACVETILTMAPIVQDTEDIQAVIEISIFLLNQPPRRVSPKLKGRILLIVEEYVTRSTAFENQALLDNVYDTISSLFSYFKDRENRQSLSRAMLAIAGKDNSLQEVAGLCAALNSFKEGRIDEPDYDRRLAAYSAISGDRETQLTPKQWLPLLHNLTYHIRDDAEFGILSSNSADGLRRFIMDAATCSSEISRGGFDIHLRGVILPALYAGAREPSDTARREYLRVMGHLLSTMPEWEPVADLSALLNDRAEDSAELTFFFNILSPATARQLEALHILEAANKQKEFGSQNLAQFFIPLLEHFIFGRADGVDDHGLGAQAIITIGNLASSLHWKHYRTTLQRYIGYVEAKPEQQKLTIRLLSKVADALVDAAENQPQERMEIDEVDASSSATTRLPLTIPTAEKLSIEVTNSFLPTLVKHLHEKDESEVSYRVPVGVIIVRLLKLLPSDQMDQKLAGVLTDISHILRSKSVEARDMARDTLVKIAVILGSSYFGFILKELRGALTRGYQLHVLSYTMHSILVAIIPICSPGDLDYCLTFVVTVIMDDIFGVIGQEKDAEGYTTQTKEIKSSKSQDSMELIAKNASVSRLIELVKPLRALLMQKVDLKMVRKLDTLMARITAGLLQNPAAETRDTLVFCYEVIQDVYNSQKPEVEEKLDPRVKKYLVQKGAKKSGDRGKTTKHTYKLIRFAVDILRAILKKHDSLRTPTNISGFIPILGDAMVGGEDEVKISAFRLLAVIVKVPFLDDEGSKLYKVAVKEATKSISMAVSTTTDLSQAALKMLAVVLRERRDVVVKDAAVDMLLAKLKDDLTEPLYRHVTFNFLRSVLDRHLETAAVYDTLDYVGTVMITNDDKDTRDLARGAFFQFIREYPQKKARWAKQLNFIVANLKYEREGGRLSVMEIVHLLLMKSSDDFVQEISSTCFLPLFFVLANDDSEKCRVAAAGLLKEIFSKADKERTQTFLGLVRTWLDQDGNEAVLKLAFQVFGFYLESDENASKNKKDFKLVLGKINSVIEVEDIREADGELLEAALEVIRASLSVFPEKILSSSSEKMWSNILRCLSHQSTSVKLSSIGLTSSYLADFAQQASDVAVGEAVVGSHGLTLDLPKVQNLARLGLSVLATRDIDEKLGAEAVQVLAFLAPRLPLRPVTEGERSDDDVEQEQQDEEEEDEEEGVERAEGIQRRTDLQHLFWKISHIIRREIPPRAVAITPKVAAMELLETICRRSSADRLRPSFKTILVPLHNLTDPSIAPPFSNDELFKTRHEALKTRAQILMDSLQKKFGTAEYSKQLLAIREEVRAKREQRSSKRKIEALAQPEKYGRDKRKKFEKNKERKKTRSKEQKVMRESFKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPD9</accession>
    <name>S0DPD9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6546 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426386.1">
        <property type="nucleotide sequence ID" value="XM_023572223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPD9"/>
    <dbReference type="GeneID" id="35397967"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04486"/>
    <dbReference type="HOGENOM" id="CLU_023464_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="2">
        <location>
            <begin position="266"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="483" mass="55618" checksum="9361B83922540EB6" modified="2013-09-18" version="1">MSGSSWASLPPEIRLQILKEGLCQGVRGSYASVCSEWKAFIEPQNFYRLELQVSCLDQLDHMTTRTASLVHQIRLNIELPRYSCRSCQWPESSSRVSQHSAIFRAAIHKLFTALSAWKRTDALVLELNTFSPSDSEHWFKNYCIGRDAQTDEESEQQQREAPGRWHDPKHGWIDGRQVESPSAKAMSRLFAPICLSLPGSIPEVHAVTQLVIRRECRRQIIPPVLRLLLQKLPRLQTMVYEPWRACRRAWKTACDKEFASLIHDGMPGHIEKLLIFEDPNSELVSAMHRDPLLNQVIDDSMTAGAEVVRALVLRSCDLKYLSVAFMVDAQQFLDSLQSTHHCHKLRSLTLTASILQRESQPRRIASFLSNASMLPREMKQLERFILWNSKRGEACAVIYHRDRSSEQATLTWRGTWHFELDYGVVESWEKVDSDLILRIENQELEAIVKQHGDALYHLRLPEEIIDPISARQLRQEAFMGEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPN0</accession>
    <name>S0DPN0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to bovine rhodopsin kinase and to YGR052w</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426482.1">
        <property type="nucleotide sequence ID" value="XM_023572343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPN0"/>
    <dbReference type="STRING" id="1279085.S0DPN0"/>
    <dbReference type="GeneID" id="35397860"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04379"/>
    <dbReference type="HOGENOM" id="CLU_008724_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="872"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="895" mass="97244" checksum="5FB70F0513093C79" modified="2013-09-18" version="1">MFSSAFKSISATNITGNYSISSAPTSTAGPWKIYDAKKKSTGKPYSVFVFDRKSLDTHGSSLGRSGAASFKKTVEEVVERLKKEASSLAKLRHPNILELVEPVEETRGGGLQFVTESVTASLSSLLQEKDEQERAGGPGGRSSRYVTEDADGTKRRRELEIDELEIQKGLLQVSKALEFLHENAGIVHGNLTPDASDWKISGLAFASPPEGSDKPTSIQGINLYEVLNMDPRLPKAVQLNLDYSSPDFVVDNNLNSSADMFSLGLMSVALYNSPHRSPLECHGSLSTYKRQFSSSSSVPSASNNYLSSRPLPRELSHDVLPRLITRRPAQRMTAREFQQSEYFDNILVSTIRFLDSFPAKTANEKASFMRGLNKVLPSFPKSVMEKKILPALIEELKDRDLLSLILQNIFKILDLLPSAKRAFSEKVRPALREIFVVNAKQTQEKDPARDAGLMVVLEHISSISSNCSGKEFKDDMLPVIMAAIECPTHSIVDAALRSLPVVLPVLDFSTIKNELFPVIAAVFSKTNSLAIKVRGLRAFVILCGGTNDNGEDDGLNGLENKKTSSSSALDKYTMQEKIVPLIRVIKTKEPAVMMAALNVLRVVGSVADAEFVAMEILPILWSMSLGPLLNLKQFQGFMELIKSLSRRVEDEQTRKLQELGGPSNGATAPSEDFMAFGGVTGTTFDQNNGATKDDFENLVKGRMGSPRSSTATPSWDDPAKSKSSTPAPTFSWSTPPPPANNPALKPPAQNAPSFRTVTPDLGRFEALTPSSTQFSQPLQPIPSQPFQPPAQLQQQPMALQQPLTASTSGSSINCASTGTMGSSMANMSLNSTSRQSSFTLPPPPGNTSTTPSSFTMTPPPTTNWSGMSSMSNTTQHTTQNNTGQKSGLDKYESLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPV7</accession>
    <name>S0DPV7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_04188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426660.1">
        <property type="nucleotide sequence ID" value="XM_023572557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPV7"/>
    <dbReference type="GeneID" id="35397669"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04188"/>
    <dbReference type="HOGENOM" id="CLU_2133711_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT64579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="113" mass="12669" checksum="05BABDCB77E2D47F" modified="2013-09-18" version="1">MAKLVTEHRLALTEPENFQNKIHLIWETFKMKYERTRSRDTVLLDALLLELDTVRPSQKYSVDTPTSGEHAFFHFDAAITDGEAKALIHEAKGIDPILAGLTPSLISAVHTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ82</accession>
    <name>S0DQ82_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Related to human PTC protein involved in nevoid basal cell carcinoma syndrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_04158</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426686.1">
        <property type="nucleotide sequence ID" value="XM_023572590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ82"/>
    <dbReference type="STRING" id="1279085.S0DQ82"/>
    <dbReference type="GeneID" id="35397639"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04158"/>
    <dbReference type="HOGENOM" id="CLU_002359_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495038" evidence="13">
        <location>
            <begin position="23"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="735"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="826"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1066"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1095"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1125"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1171"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1212"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="14">
        <location>
            <begin position="589"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT64605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1274" mass="141174" checksum="1F066CFDA9F08D4E" modified="2013-09-18" version="1">MHQRIVPQLGAVAALLAGLGFAEQYTPKHEAGRCAFRGHCGKQSFFGKELPCVDNGLAEDPDEELRNELVELCGQKWKTGPVCCSLDQVKALKSELGTPSTLIGSCPACKDNFFNLFCTFTCSPDQSLFINVTDSAPKNGKQLVTELDQLISEKYGSGFYDSCKEVKFGGANSKAMDLIGGGAKNYTEMLKFLGDKKPLVGSPFQINFPTGYSDHDLHPLDMTPKKCDDEDPDYRCVCVDCPGVCPKLPDVKDSKSCRVGLLPCLSFASIFVYSVLLLTLILAVFGHIAYKKYSQHRVERTRLLHESSHSDDEDEGGPVDTEAMRERPTKRYWVNDKCDKAFYQLGHIAARFPGWCIGLSLLFVAILSVGLFRFDLENEPARLWVSPSSAAAQEKAYFDSNFGPFYRAEKVFLVNDTDPSGPGPVLTYDTLKWWIEVEESVKKIESPVYGKYFQDLCFKPSNDACVVQSVSAYWHAKGGFDPKYWKEDLRGCAKSPVDCRPDFGQPIEPNMIFGGYDDDVVDAHAITVTWVVNNAQEGTDALARAVDWENSLRDRLLEVQQEAKERGLRLSFNTEISLEQELNKSTNTDAKIIVISYIVMFIYACMALGTPLKHIFRNPAVLLVESKVTLGLVGILIVLMSIAASIGFFSWVGLKATLIIVEVIPFIVLAVGVDNIFLIVHELERVNVSFPDQMVEERVARALGRMGPSILFSALTETVAFALGTAVGMPAVRNFAAYAAGAVFVNAVLQMTMFVSFLSLNQMRVEDHRCELWPWWQITKARIHLNGASSFSQGSSRGSDMAEESLLQVFIKNTYAPRLLGKKVKLAVVTIFLGLFAGGLALLPKIQLGLDQRVAIPDDSYLIPYFNDLYEYLETGPPVYFVTREVDASKREQQQEICSRFTTCQDLSLTNTLELERQRSDISYISSPAASWIDDFFLWLNPIYDQCCVEHGQTCFADRKPAWNTTLYGMPEDEEFIHYLKKFLSSPTGDECPLAGQAAYGQAVVLDDKGNHVKSTHFRTMHTPLRSQEDFIAAYSAARRIASDIKERTGADVFPYSVFYIFFDQYLSIVPLTAVLLCAAVGIIFAVATVLLGSLLTAAVVSVTVVMSVVDIMGSMALFNVSLNAVSLVNLIICVGISVEFCAHIARAFMYPSRTVMEGNSNAFRGRDARAWTALVNVGGSVFSGITVTKLLGVSVLAFTRSKIFEIYYFRVWLSLVIFAALHALVFLPVALSIAGGQGYVDPESEGTAAQDLTDRRWRAIRINDNSDSEEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQP9</accession>
    <name>S0DQP9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_00529</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424954.1">
        <property type="nucleotide sequence ID" value="XM_023573191.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DQP9"/>
    <dbReference type="GeneID" id="35394014"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00529"/>
    <dbReference type="HOGENOM" id="CLU_006184_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001195">
        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="16">
        <location>
            <begin position="6"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="187"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="493"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="744"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="977"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT62873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1307" mass="149982" checksum="9C7D03D55E1A569F" modified="2013-09-18" version="1">MSRIDKLSISGVRSFSPSVREAIQFNTPLTLIVGYNGSGKTTIIECLKYATTGELPPNSKGGAFIHDPKLCGEKEVMAQVKLQFRSINDRQHVATRSLQLTVKKTTRSQKTLDCSLVVVNNGERTTTSTRQAQLDEMIPERLGVSPAILDAVIFCHQDESLWPLSEPAALKKRFDEIFEAMKYTKAIDNLKVLRKKQVEQLGKLQNDEAHNKVNKDRGDRAEKRMKALQAEIEGSRETCESISSEMEETQDKIRNIRETANSHLAIVQNLNTKREQLEYREEAVKELKATIDELPDDDGKLEGDLAHYEDRMQHLQDEADQNKAQYNELQTELGKSRKDLSAKLSEQGKHQSDKDKYERQLKIRMETIQEAAQSYGFSGFDGDLSDHHVKSFNDRLQKLLSEKKRDLERLQKDNSAELDRATGVITELEGRKAARTQDRVSAKQRMGAIEKRTSVLQNESSQIDVDEGAKAVLDGQMQDLESRFQTSQKTFENADWDRQISDENDKLHQLENENDKLGRELVECTRLASERAQLDYRKKELADRKRKLDTLTSTWKPKLDKILGSDWQPETLDSKFQALIKDQSKVVSEAQKRREQIRQKQQKVEFKLRTSKESHEKKSKEAATCQQQVVSALLAVRDHATVEDYKEEIEVTESQVEELRNELSLFDALVDYYTKCKRLLDTKRKCQLCDRHFDDNQAASMERLSKRIDKHLDPRGKIDTEKDLKDTVANLEKLRSVRGSYDTYERLTAELPSLREECKVAEAEFDALERQVEEQGSVLSAEEEKQKDLEDMSKTVLSIAQTVKDIAESENQVDRIMSQQMSGGVTRSPDEIHELQAGLSDQMRNLKNRIAKLTTDRQRTKDQLNSLELEKSELRNKISRAAGQLDKKQDLQNQIQALKEEASHQRNVIQRADEELETIEPSITEARSARDEVLRRGRAKEQVIAEARDAVANSVNEMKMMDADIQDYIDRGGPSNLASNERSIATLEKAIASTEKEVTDLTVRTNKLKQDIDNGDRKKKNIKDNLNYRKNLRTIDVIRQEIAELEDRNADEDYERLQAEARMQENHYNRLLAERGSVMGSMKTKDEELGRLLQEWEMDYKDAKRKYRESHIRVETTKAAIEDLAQCSSAVDKAVMQFHSMKMAEVNRIAGELWQSTYQGTDIDTILIRSDNESNTGKRSYNYRLCMVKQDTEMDMRGRCSAGQKVLASIIIRLALAESFGVNCGLIALDEPTTNLDRDNIKSLAESLHMIIKARQAQSNFQLIVITHDEDFLRHMRCSDFCDSFFRVKRDERQNSVISRESITKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQY7</accession>
    <name>S0DQY7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425034.1">
        <property type="nucleotide sequence ID" value="XM_023573289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQY7"/>
    <dbReference type="STRING" id="1279085.S0DQY7"/>
    <dbReference type="GeneID" id="35393927"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00442"/>
    <dbReference type="HOGENOM" id="CLU_041042_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="400" mass="45712" checksum="6868B56DB0C10FCB" modified="2013-09-18" version="1">MDDPGWSWPAWKFGMKRDDLFHTLHEKYNTFTFNLQDPEAFHHDVYEISRDADTIDDFHRLLDERKQQRIHELHESLESLAVEIIANPKLMDSEHWQYALQLFRTKSFDSIVRYFASYLPEQYLDHNDRDHDAISIASLSSFSETNSVKTESTTASSVDDVSSFFDEPILTKGPLSIHTDIRSSSVVQAPPSPPHSEAAHGDESSVSSPTSMESHEYSTPPSRSMSFSGSETAAAISDLTRSLVHDEDETSQFDDGDFAVASDSDCEESQSSLDVMDDGEQSNDKYEDDLEEEDDFPTTQFPEDASDGCDFYDDTPNFDDTPTPRQESIAPCYIEYKSVAAWRIPSPRRPTSPSPRSHHPYRREGSSLKDIRRSPEESMSKIQKPMHEQRKRPTFRKRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR79</accession>
    <name>S0DR79_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426003.1">
        <property type="nucleotide sequence ID" value="XM_023571753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR79"/>
    <dbReference type="GeneID" id="35398387"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04906"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT63922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="499" mass="55729" checksum="291B3E6DF78E9122" modified="2013-09-18" version="1">MSDYDRKETLEEKASTSEVDLAGVNDPYAGLTEEEAREAEKKLLRKIDMRLVPWLCLLYLICFLDRTNIGNAKIAGLLDDVHMDTHHFNLTLTIFYISYAVFEPLANVLLKWSKPSIFIPAIMVLWGASMLGMGFVKTWDGLMAARWFLGVTEAGLFPGINYYLSCWYKRSEFGARAAWFFSAAALAGSFGGLLAAAIQKMDGVSGIAGWAWIFILEGLMTIVVGIISFWMVHDFPTDAKFITEEERARVIYRLTADKQSSAQDEQFKMKYFWQSITDWKTYCGMLIYMGPLMPLYSFSVFLPTIIQNMAFTDKKAVVKNQLLSVPPYALAAVVTICVGIYSDRLNKRGIFNLCAAPVGMAGFIMLIASTNPAVQYTGCFLGALGIYPVIPITISWVANNVEGVYKRGITLGFVIGWGNLNGVVSSNVFINGPRFYPGHGTVLAYMFCGIFCGSLLMYFLLSRENKARLAGERDHLVEGKSEAEIHEMGDKRPDFLYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS63</accession>
    <name>S0DS63_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mesaconyl-C4 CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_02343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427485.1">
        <property type="nucleotide sequence ID" value="XM_023574061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS63"/>
    <dbReference type="STRING" id="1279085.S0DS63"/>
    <dbReference type="GeneID" id="35395825"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02343"/>
    <dbReference type="HOGENOM" id="CLU_028690_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000103">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF2">
        <property type="entry name" value="N-TERMINAL OF MAOC-LIKE DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT65404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37982" checksum="C92668120A79B4CC" modified="2013-09-18" version="1">MKLFTTSRLGNPLRLGCRSSQRRSASTLGSDVAQQLLSRLKDRVMTRRQVLDGNQLQKLSLTLNRRYLHPGHDIAETAPANGTVLPAGYHLVYFTPNGTEFELGVDGTDRSFNAPAPFTRRMWAGGCMQWAKNCPLRVGEEVEERTRLLAAEPKKSRDGTEMIVVTIEKEFWGSQGLSLTDQRSWVFRTELPEPLENTTVPTSLVTVQTNVQTTQHSPKGYPERQMTWSPISLFRFSALTFNAHRIHYDAAWSQGVERHRGLVVHGPLNLINLLDYWRDVHAVPDGTGPSEITYRALSPLYSGERYTVKTSPEGQSKGDVEVLVEREGTLCMKGKISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS72</accession>
    <name>S0DS72_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_01197</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425499.1">
        <property type="nucleotide sequence ID" value="XM_023581416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS72"/>
    <dbReference type="STRING" id="1279085.S0DS72"/>
    <dbReference type="MEROPS" id="M49.004"/>
    <dbReference type="GeneID" id="35394682"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01197"/>
    <dbReference type="HOGENOM" id="CLU_011977_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000004">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT63418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="762" mass="85231" checksum="7E88963D784A4AAA" modified="2013-09-18" version="1">MPSPNLISPSLMIQRLPSLRTTAFKSTILTRRPIPRFTKSFNHQSLHKFSTSATVMNSNELVHYLADKPPSVVRLEIEKHFDALNDKQKRYAHFISKAAFAGTRIVLRQISPESEPIFDLILTLHKSANGDWTALAKKAGVEEDELARFLEYAAMFLGNNGNYKSFGDSKFIPRCSEKTVAALASTSPEANKFYEATNGGIFSSSNPAMMHLGYPDDGHMTTYYPESSHITKDEIKAVSDWMESKGLLPENNRLRKTSEGNYEILIASAVKEIPSEGGDIGKQTEFTVEDGPLKSKTIQLVYGDYAEEMKNITAFINGAAENAENDTQKKMHEAYSKSFESGSLEAFKDSQRYWIKDKGPMVESNIGFIETYRDPAGIRGEWEGFASMVNLERTRAFGELVKNAPKLIPLLPWGSEFEKDKFLSPDFTSLEVLTFAGSGIPAGINIPNYDDIRQTEGFKNVSLGNVLSAKAPDEKIPFIRDEDLEVYKKQRDASFEVQVGLHELTGHGCGKLLQETSPGTYNFDKEKPPVSPVDNKPITTWYKPGQTWGSVFGSIAASYEECRAELVAMHLSCEFPVLKIFGFGDGSEDINGEAGDVLFASYLSMARAGLASLEMWDPKSQKWGQAHSQARFSILKCFLEAEDDFCKLDYKQDDLSDLTIKLDRSKILTAGRDAVAKYLQKLHIYKSTADVKTGTDFYMHMTTVDTEFWGKKVRDIVLKNKQPRKVFVQANTSLDEASGKVSIKHYEASLTGMIESWVERNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSE6</accession>
    <name>S0DSE6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to seed maturation protein pm25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427457.1">
        <property type="nucleotide sequence ID" value="XM_023574031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSE6"/>
    <dbReference type="STRING" id="1279085.S0DSE6"/>
    <dbReference type="GeneID" id="35395797"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02315"/>
    <dbReference type="HOGENOM" id="CLU_142972_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007011">
        <property type="entry name" value="LEA_SMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04927">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP" evidence="2">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="113" mass="11497" checksum="4877C095D054096F" modified="2013-09-18" version="1">MADLPTKDDIKSQAVDGRPITQAEASAIASEESALTGSGPIKGGAAATAQSLHDKQQNFLEKAGEVVRKPPTEVTKEDAAEVQRAEARAKGGPPGKGSTAADVQSVADTNTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTI5</accession>
    <name>S0DTI5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to urease accessory protein UreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427816.1">
        <property type="nucleotide sequence ID" value="XM_023574469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTI5"/>
    <dbReference type="STRING" id="1279085.S0DTI5"/>
    <dbReference type="GeneID" id="35396187"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02705"/>
    <dbReference type="HOGENOM" id="CLU_021703_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="329" mass="35984" checksum="D4A25F560A9FE4D7" modified="2013-09-18" version="1">MDSPFPPSSSSPGDGRIVVGLLPAGESGLETMTYQYPLKLISPAPSSSQPSTLVFLLSYGGGLVAGDGVNLTIHAKPQAKLSIATQGHTKIFKSPTADVVTTQNLDVTIEDGASMCLLPDPVQPFEDSVYAQKQIFKLKSQASLCLLDWVTQGRVARGENWSFRKWTGRNEIWLQDPQTTTADRLLVRDSIILSRDASKSVGRTLPEMMQHMAISGTLILRGSKTKSLGEFFRNEFAALPRIGARDFRSPEAMARSTTDVSDFERWRLQRLKEEKEGGVLWSAANVRGCVVVKFGAKTVEAGREWIGSMIIQEGSIASEFGDKALMCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTL5</accession>
    <name>S0DTL5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_02742</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427851.1">
        <property type="nucleotide sequence ID" value="XM_023574510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTL5"/>
    <dbReference type="STRING" id="1279085.S0DTL5"/>
    <dbReference type="GeneID" id="35396224"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02742"/>
    <dbReference type="HOGENOM" id="CLU_000688_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000011">
        <property type="entry name" value="Peroxisome biogenesis protein peroxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="534"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="864"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="221"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="704"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT65770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1208" mass="130434" checksum="F58E46F160C84B53" modified="2013-09-18" version="1">MPPRRNAQSVPAEISLSHLKSCLVNLPTSLVSLLVNVNTPAQNVIIELSYREASPTGAGSQQRSIFVGWTGMPSKRRTAPPGTRDGLNSSRSSRDQEVQLVELDATLAKSLGISEGQKITATIHLDPPLAHTINIEPLTPEDWEIIELHATFLELNLISQIRALPNPLYKIGDNPVEPHALTLHLSPTSTANIKVISLDPSPPADLPFAKISPDAEVIVAPKTRQKSSHSSGDHRSVASTSKSKRSATSTVRRRSAKEERRPTMFLRGLDRSSCEEWFDEGPLVQDLSVWVDHDLVSGEAFKGVNYVAVDVIRPAGLQQPQPEEGGVPAGTTAATKVIAHLRSWIDPPNSQSVALSSPLCASLGCSGMVGGIVKLQAAPQQLPKTAVQSIKVFPFASSAKTVEGLRFGGESKAEKEESAKRFRQIYAAARGTDGLLQGPLTDGSIMGLYDGLDPPQGWEGGIIKFTFGGDFQENKDAANWLLGLDTKLPIDFQPPTPRPSWLTETDGFERQPTHDSLLVGIDSLLENLQSNLVHLSSVLLTGGMGSGKSSIARYLAQKLRQDSLFHTLYYPCRKLVNDETRISTIKETLNRLFATASWGARLNGTAVVVLDDLDKLCPVETELQVGNDNGRSRQVGEILCSIVRQYCTRDSGVVLLATAEGKESINGVVVSGHVVREIVELKAPDKESRRRVMESIVMQDAMTAEEAQTQFSDESRPQTADGSMTEDSGAWMDGASHASKESPPAKTSGFILDSDLDFLDISGSTDGYMPGDINVLVSRARNEAIIRAIAESPDSTGAIHLARADFDKALKGFTPASLRNVSLQSSSTSFKSIGGLQETRQVLLETLQYPTKYAPIFAQCPLRLRSGLLLYGYPGCGKTLLASAVAGECGLNFISVKGPEILNKYIGASEKSVRDLFDRAQAAKPCVLFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQMDGAEGLSGVYVLAATSRPDLIDPALLRPGRLDKSLLCDMPSLEDRVDIIKALFQKVRLSNELTESDGPLTDIARRTEGFSGADLQALVSNAQLEAIHDVLDVDGPTVTSKRSNGTNGKSNTTPSFVQFRYGKDAKPLTGATPKSKSAALVENASILAKLEEIKIARKKSKQIHGAPATNTDAKAQSSDQREVVIEWDHLIKALGSTRASISSEEKARLQRIYTEFVVGRSGQMKDGQGSMEIGGRSSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUL5</accession>
    <name>S0DUL5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable MAP kinase kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428242.1">
        <property type="nucleotide sequence ID" value="XM_023574977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUL5"/>
    <dbReference type="STRING" id="1279085.S0DUL5"/>
    <dbReference type="GeneID" id="35396643"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03161"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000294">
        <property type="entry name" value="Map kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="229"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="526" mass="56654" checksum="F4EDF1CDD93C68F0" modified="2013-09-18" version="1">MADQQPQSSDSTPLPQQPAAPTPISLPTHNSGPSPVPLLRPAIPGARSGGARTPRLGLAIPPSPNAKAVGNQGAAAAAPSRPPLPTLHLATPMGSQVTPHEQLPRSQCAAQASAGGGSESSAAHSRSGSFGPLDGRVSNPTSAGSQYSALSFASQYGIGVSRPQGTPDPVSAVGSMYSERSEGGVSMERDGSLQGLEAFDKLSLEKARTLDVDELDEEGWRIASLEKRIVEIGNLGEGAGGAVTRCKLKGGNTVFALKVITTNPDPDVKKQILRELGFNKECASDHICKYYGAFVDPATATISIAMEFCEGGSLDSIYKEVKRLGGRTGEKVLGKIAEGVLGGLTYLHTRRIIHRDIKPSNILLCRDGAVKLCDFGVSGDFGTKGEANTFIGTSYYMAPERITGQSYTITSDVWSTGVTLLEVAQHRFPFPADGTEMQPRAGLIDLLTYIVRQNVPKLKDEPEMDVYWSDNFKYFIECCLEKQPNRRASPWKMMEHPWMVEMRSKRVNMVKYLSFVWGWDEQPKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUU6</accession>
    <name>S0DUU6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428435.1">
        <property type="nucleotide sequence ID" value="XM_023575218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUU6"/>
    <dbReference type="STRING" id="1279085.S0DUU6"/>
    <dbReference type="GeneID" id="35396859"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03377"/>
    <dbReference type="HOGENOM" id="CLU_045005_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="308" mass="33893" checksum="E5B381AEA6A73E4A" modified="2013-09-18" version="1">MEITRRFSRSCSKAEIASVGISPATSAVFAIYTAAQTSQSWIDVFDIKTQSGYSKTSGSRAVFSPNGSKLATIRDWTVQFTGGFDFHHSSTVFLRDYGSGKTACELKEAKGEPIAWSRDGRLIAVGEARNRIGVWDVKHGVRVGKVLSHIDAVTHAAFLPDQSLVTISRDGTLRITNTKTCKTIRRLEIDGSNNPRALAVSLDGRRIVSVWGTSVHIWIPSANDLTSYNLNAVRPCEGWPLAISPDCRYMLCRTEDGFDIMDVATGTIVYDEVTEEMVMSGAFDEDAKVLVLGRMDGVVEVRDVFDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVT0</accession>
    <name>S0DVT0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03643</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428682.1">
        <property type="nucleotide sequence ID" value="XM_023575512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVT0"/>
    <dbReference type="STRING" id="1279085.S0DVT0"/>
    <dbReference type="GeneID" id="35397124"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03643"/>
    <dbReference type="HOGENOM" id="CLU_019582_2_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="442" mass="48712" checksum="39723294BB4CC4F1" modified="2013-09-18" version="1">MDPDRYQSSEEIFAGLPTDTLGNGLPASFVKSGIDRLLEHDIDPEHNLGSFVSTGLNDIGERLLMESYKKNLACQNEYPGVREIHDRCVEILGTVWGASCNEKPTGWAASGSSEAIFLAILAMKRKWQAENGGVAPFNGPTLNIITGSHAHVAVTNAAKANDIEIRSVDVGPESNYSFDPSKMQGLLDNSTIGVVLVLGNTYTGHFDPIENVNTVLDNYEQLHGRNIPIHVDAASGGFVAPFNCGKPNRWDFTIPRVISINASGHKFGLTAAALGWIIWRDQRFLPSDMLHQSSYLSGHHELPTLRYSQSSSSVLIQYYHLARLGRQGFENIIQDLLQRSSALGKTLEGTGIFTCISESHRTTENTLPVVVFRVNPAVQDQRPEFTEQWISDQLFDKGYSVPCSKLPTHGEDIEVLRVVIRPSLKPTVLDSFITELLSLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX84</accession>
    <name>S0DX84_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to nucleolar 100K polymyositis-scleroderma protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_13241</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429141.1">
        <property type="nucleotide sequence ID" value="XM_023575903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX84"/>
    <dbReference type="STRING" id="1279085.S0DX84"/>
    <dbReference type="GeneID" id="35406695"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13241"/>
    <dbReference type="HOGENOM" id="CLU_010129_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
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        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="449"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="612"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="710"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="739"/>
            <end position="748"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="802"/>
            <end position="811"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT67060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="811" mass="92611" checksum="EE4B5BBB34A75334" modified="2013-09-18" version="1">MEQSQDFKSLQESVQKSLISTIKTVNRIAAEDLSFQRTVNPSVGQLLEDRTSRILELSTQLLLTAGKACGVKAPKLEDVEDIEMNWRGVVDVVDSSLEKADTALDEYTGLVKRKEPTLPDPANKSKKPKSTNKVIRNANMTKPQLLFERKPDNFAPAPWKPMLTSKPNAKLSLEESLKVVPNEAGTPQYQHPYEHEIVRMSYPKRVFKESEPIMYQPVETTAVTFVDTYEGILEMLEELKGAKEIAIDLEHHDFRSYVGLVSLMQISTREKDWIVDTLQPWRHKLEVLNQVFTDPNIVKVFHGAYMDMVWLQRDLGLYVNGLFDTFFACEQLHYPAKSLAYLLSKFVDFDADKQYQLADWRIRPLPEEMMYYARSDTHYLLYIYDRVRNELVAASDRGDVNKDYIGRAVEKSKEQSLSRYEHPGYDEETGEGSRGWYGYIFKNSHLAFDSEQFAVFRALWRWRDNTARKEDESTNYVLSTRDITEIARINPPDAKALHSLLPLNASLARPRFNEIWEQIKETKAKGGPSLLHFFTSMAPDSVRKNGMPIAARQTTKLPDLDEEITVSRLTRSQLFGDMPISSKWDPSTRPTKTGEELIPFPWQRFIQQGSIKGDVQHDTAAEEVKVPEQTDNVESGAGNAEVEEDDEEFTLRRGQKRKSQAIEESESSEEGTDSSQYDSDEEMQEGGGVIAVEDEPSQKASRSARRKLRKAEEKKAEEERLLRQEAKKIRKAQKKQKKKQDDKTKKFDAVPFDYSKAASVLHSNRDSNSGQADGKGKKKVFDPYSKSADTDIKGARKAPPVRGERSATFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX90</accession>
    <name>S0DX90_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_13246</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429146.1">
        <property type="nucleotide sequence ID" value="XM_023575909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX90"/>
    <dbReference type="STRING" id="1279085.S0DX90"/>
    <dbReference type="GeneID" id="35406700"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13246"/>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_1"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="7"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="88"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="266"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT67065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="525" mass="57442" checksum="CE94C87A419FA95A" modified="2013-09-18" version="1">MSKTDQKACLIVIDGWGIPSADSPQDGDAITNAKTPVMDALYKDSKGYTELEASSLAVGLPEGLMGNSEVGHLNIGAGRVVWQDVVRIDQTIKNGELAQNDVIKKTFQSAAAGNGRLHLCGLVSHGGVHAKQTHLYALLKAAKEYGVPKVFIHFFGDGRDTDPKSGAGYMQELVDTAKEIGIGEIGTVVGRYFAMDRDKRWDRLEIALKGLVLGEGEASEDPVATVKARYERGGDLDRDEFLTPIIVGGDERRIKDDDTVVFFNYRSDRVRQITQLLGDVDRSPLPDFKYPMIKPLVTMTQYKGDYPFEVAFRPQHMGNVLAEWLGKQNVEQVHIAETEKYAHVTFFFNGGVEKVFPLETRDQSQDLVPSNKSVATYDLAPEMSADGVADQVVKRLGEQKFPFVMNNFAPPDMVGHTGVYDAAVIGCEATDKAIGKILEGCKKEGYVLFITADHGNAEEMKFPDGKPKTSHTTNKVPLLMANYPEGWSLKKTDEGVLGDVAPTVLAAMGLPQPEEMTGKSLLQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXN4</accession>
    <name>S0DXN4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_13497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429377.1">
        <property type="nucleotide sequence ID" value="XM_023576189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXN4"/>
    <dbReference type="STRING" id="1279085.S0DXN4"/>
    <dbReference type="GeneID" id="35406951"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13497"/>
    <dbReference type="HOGENOM" id="CLU_819228_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT67296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="339" mass="35895" checksum="6251D3B1A8F26B27" modified="2013-09-18" version="1">MSETTQSPEDAAAQRAAEQARLRKERREAKLKAGGSARLNKITGLGGRIPGEPEPTTASTAMADAPTPAPAPAPAASASAVSATADHADPEEVDISDHYYEPKRTATSRTNAPEITEPAISEDQLRQMMLGFERGNGSGTASPAPGAAEEDPMMKMMSHLMAGAGLPAGSMPPFPGMPGMAPGQGPPVPPTAVRNSASTNLWRLLHALVALGLGFYIVIFTPFTGSKIERERAALAGTTPADPLIAAAEPELETELEHRKKLFFWTFATAESLLLTTRFFLDRRGSPPSGIVGTVVQFLPQPAKGYVEVVMRYGQIFTTVRSDILACIFVLGAVAWFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYK6</accession>
    <name>S0DYK6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428573.1">
        <property type="nucleotide sequence ID" value="XM_023575385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYK6"/>
    <dbReference type="STRING" id="1279085.S0DYK6"/>
    <dbReference type="GeneID" id="35397009"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03527"/>
    <dbReference type="HOGENOM" id="CLU_108553_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="182" mass="18426" checksum="95A43B7E3EE06302" modified="2013-09-18" version="1">MSSTTLSTASAVPTACTNLYDTPNQDNTCAMPFKDNHTEIMQKCCGDAKIVSYYNGCGLYCVALDQTIGELAKCLFANGAPDADVFCSGSKKTTKTKDADVPATAQASVISGDDDKDDDDKSSTGTASGTSTSTGTSSSSSETSTESGNAAAGFAPKSSINTLGLAIGALLFSSMAAGAFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYP2</accession>
    <name>S0DYP2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to SUC2-invertase (Sucrose hydrolyzing enzyme)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_14694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429785.1">
        <property type="nucleotide sequence ID" value="XM_023576656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYP2"/>
    <dbReference type="STRING" id="1279085.S0DYP2"/>
    <dbReference type="GeneID" id="35408074"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14694"/>
    <dbReference type="HOGENOM" id="CLU_001528_3_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000002">
        <property type="entry name" value="Invertase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF2">
        <property type="entry name" value="INVERTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495330" evidence="5">
        <location>
            <begin position="19"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="45"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="438"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="546" mass="60141" checksum="A3F90EFCFA87117D" modified="2013-09-18" version="1">MRGLLFSTVAGLVQLSAAQSSTTPSVPTGTPITGDYNGTYRPQIHFSPPQHFMNDPNGMFRDADGLWHLYYQYNPTDVVAGNQHWGHATSKDLYHWVNQPIALFPPEKDTYVFSGSAVVDVNNTSGFFPDQDNGVVAIYTLSSPTVQDQAIAYSRDGGYTFTPYANNPVINSTSTQFRDPKVIRYDDSWIMVVAYPQDFKIGIFESDNLKDWKPTSNFSHHGLLGLQYECPNMIPMPYVDGDGNKQDDMWLMAISINPGAPLGGSITEYFPGTFNGTHFEAVDAAARIADFGKDNYAGQWFYGLSEDEYPVSIAWASNWQYTSVVPTGDEGWRSAMSLPRENYLTKAKRVGWKLVSKPYDLSPVLGRELASNSSFGNGTLIVDYSDVESNAIYWEVNVTGIPDGGIPPTSSMNWTFSSPITNEAIKSGYYLGGDPVFFLDRGGVKGFDNIFYTDKTSLGSLATENGTWSLSGVIDRSIYEAFLNDGVDSVTNTFFSTEPLTLMIFSATDLPEDVKVSVKVHALESAWKEMENDDGLVAGNRTSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ07</accession>
    <name>S0DZ07_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429736.1">
        <property type="nucleotide sequence ID" value="XM_023576581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ07"/>
    <dbReference type="STRING" id="1279085.S0DZ07"/>
    <dbReference type="GeneID" id="35408007"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14626"/>
    <dbReference type="HOGENOM" id="CLU_033726_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28174" checksum="4AC80EC231535A87" modified="2013-09-18" version="1">MKPNWEPFVKSTEDDWTAVPDPAQRKRIQNRLSQRARRSRLAGKQKQVAQYEVNEDAGALVRRDAGSSPGQSSTEGSSMAVTEVFDASLFHTQYTSEQPTMDSHYLILTDLTAATALAVIAQRLDLDCQRIPGFNIRALADSLPSNIAPTQLQKSVPHLSYLDMLPWASLRDKLLKSLSIINEEEFARDMQYGSLKVWGIVPWDPMGWEVGESFAKRWWFLMDSGILQTTNFWRSQRGERPLTLASLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZY9</accession>
    <name>S0DZY9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_06859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430176.1">
        <property type="nucleotide sequence ID" value="XM_023577047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZY9"/>
    <dbReference type="STRING" id="1279085.S0DZY9"/>
    <dbReference type="GeneID" id="35400336"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06859"/>
    <dbReference type="HOGENOM" id="CLU_028200_6_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485455" evidence="8">
        <location>
            <begin position="24"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="9">
        <location>
            <begin position="143"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT68096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="462" mass="51249" checksum="DD1BD258678B4D02" modified="2013-09-18" version="1">MKLFAILRLFILILPSIFRQVGASSPTTAQRLEDASQCAIKCFSQFVDKPTFSTANKVRICDDHKLSNTVASCIHTACPIRDLFGRNFSRSALQGSGYSHGRLWADFLKLEQTNCGRPELDNDHNIRGINYTILGIAVFSIVLRTVTKSYHFSRWGADDYLIIAASVFTGVQCIIMGLMTFAGLGRNIWTLDDSTITTFHIYLLVVQYAYVLSLCLIKLSILYFFLRTFPDPKFRLIIKCTIAFNIVTTIIVTICGALQRQPIKLLWDGWKEYPPRGITLNIPAIIFFHAGVNIALDIWMFALPLTQLYSLGLQPKKKAGVMVIFGVGIFLIAASCIRIPYLLDFTRTLNTSSDAQGFVVWSNIESGVGILVACMPHMQPIFRAIAARGRSWNILPKSSSSSTEGIFVQRSLATIKMSRTDGTTLLEPDDLVLHDTGGLLSEPSSAKVDSKFGSLSETGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E001</accession>
    <name>S0E001_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428114.1">
        <property type="nucleotide sequence ID" value="XM_023574826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E001"/>
    <dbReference type="STRING" id="1279085.S0E001"/>
    <dbReference type="GeneID" id="35396508"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03026"/>
    <dbReference type="HOGENOM" id="CLU_145563_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="96" mass="11092" checksum="35FF74084D761ABF" modified="2013-09-18" version="1">MLRTTFRQTAAFRPVRCFSTTPRVMTEGATGSVRPTGGSGDAFQRREKASEDYAIRQREKEKLIELKKKLQEQQQHLDRLSKHIDEITREQGGEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E052</accession>
    <name>S0E052_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_07010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430319.1">
        <property type="nucleotide sequence ID" value="XM_023577214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E052"/>
    <dbReference type="STRING" id="1279085.S0E052"/>
    <dbReference type="GeneID" id="35400487"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07010"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF2">
        <property type="entry name" value="ZINC-BINDING DEHYDROGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="4">
        <location>
            <begin position="93"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT68239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="460" mass="49621" checksum="99B9D7F370B55344" modified="2013-09-18" version="1">MSAYLSLSAEPAFGARIPLSFVTDSPQEHPVSQTTSDSQPRYTPPTDLAAQDQASDSGEQHPIPSSQTVLLLHGLRQPYQITDGHPVPSTKHDHELLVRTDTIGLNPIDWKSPDYGFAIPELPYISGREASGTVVLAPQTPSRIKSGDKVIVISTDYRDLRKATYQQYVVASDFNVVRIPKEITIKQGATLGVAYVAAALSLGICLGVDFTSVQDGPNILNLVREVPEEALPEDIRGECLNSILPNEGAKAGDWIAIWGGSSTSAVLAVQLARLVGLKVALVVDNAKHGVRISENPVLRPDLLVDSHDPERAVAVLRANTKGKLRFGIDTRGKDTAEVLLRALGPEELHRSAANVTSPPSTPPAEPIVPAHLVGMSGLPKTGQSAGVIFHTIPFKLYHEVPEVGEVLSRWLERLLSSRALVPPRIIDVEDGLHNVNRGLDRMRKGEISGGKLVVDLKTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E088</accession>
    <name>S0E088_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to SCJ1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_07058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430364.1">
        <property type="nucleotide sequence ID" value="XM_023577268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E088"/>
    <dbReference type="STRING" id="1279085.S0E088"/>
    <dbReference type="GeneID" id="35400535"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07058"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495416" evidence="7">
        <location>
            <begin position="21"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="40"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="164"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="164"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT68284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="431" mass="48610" checksum="C85F087DB7C75AD2" modified="2013-09-18" version="1">MLFHTAALVVLLALVQLAVCAQDYYKVQQFPYATSMQILTVVKVLGVSRQAGKKELKQAYRQLSKKFHPDKNPGDDTAHDKFVEVSEAYDVLSDEEMRKVYDQYGHEGVQQRRQGGGGGGGHDPFDLFSRFFGGHGHFGRASSEPRGHNVEVRVEISLRDFYNGATTEFSWQKQHICEACEGTGSADGQVDTCHTCGGHGVRIVKRQLAPGMFQQFQQRCDACGGRGKNIKHKCKVCQGERVERKATTVQLNVQRGAARDSRVVYENEADESPDWVPGDLLVTLSERAPSYDNNPDKTDGAFFRRKGNDLYWTEVLSLREAWMGGWTRNLTHLDNHVVQLSRPRGKVIQPGHVETVAGEGMPIWHEDGDSVYHKTEFGNLYVEYAVVLPDQIDSNMESDFWSLWEKWRLKSGVDLHKDSGRPEPAHTRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0J1</accession>
    <name>S0E0J1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_07157</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430459.1">
        <property type="nucleotide sequence ID" value="XM_023577378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0J1"/>
    <dbReference type="STRING" id="1279085.S0E0J1"/>
    <dbReference type="GeneID" id="35400634"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07157"/>
    <dbReference type="HOGENOM" id="CLU_012862_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="178"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT68379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="622" mass="69172" checksum="45B4CA1A329FD069" modified="2013-09-18" version="1">MDKFLQKTQARATRSSAINASQKFLSQLEPEDDKNSLTKNRAAKRPSPSQDEDFDASERDATPENDIKLPVAKRRKTQPARGKNANSKIHEALFSNEGETCQNPCTPPSRHHPLSYHRPLLLKESSSRQALLSWFDGVSTKRSMPWRKSWINPKDHGQTELRNLLERRAYEVWISEIMLQQTRVAVVIDYWNRWMEKWPTIHDLAAASADDVLSAWRGLGYYSRATRIHEAAKLVVNDSTMEGLLPSCTQDLEAKVPGVGRYTAGAISAIVFGRAAPMVDGNVLRVLSRQLGLFGNVKTNKVVIDTLWAAADALVKAIARDGTDAQSDEEVETSDRPGRWGQALMELGSTICIPKPNCSECPIASTCRAYAEGQTLIPRKGRDTKIGDIEDLCDLCEPFEESTALDEPEVKVEAKASKKAKTNGGQGKQMTLAAFAFKGPSGDKKASTKVETGPGPRDMEVIVDHARKFPLKVIKKAVREEETLVCVIRRGDGQYLVQKRPEKGLLAGLWEFPSYIMEDPKEGNTPAKRRSKALSYVSKLAGEHGGKAVRPKHMEELGSVPWLFSHLKLTMHVHLFSLEDGDLNDTKSLASSRLRWATPEAVDEESMGTGMRKCWTLAKDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0R0</accession>
    <name>S0E0R0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_07154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430456.1">
        <property type="nucleotide sequence ID" value="XM_023577375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0R0"/>
    <dbReference type="SMR" id="S0E0R0"/>
    <dbReference type="STRING" id="1279085.S0E0R0"/>
    <dbReference type="GeneID" id="35400631"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07154"/>
    <dbReference type="HOGENOM" id="CLU_115154_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099617">
        <property type="term" value="C:matrix side of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT68376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="123" mass="14514" checksum="8C1BBD5E163A04A3" modified="2013-09-18" version="1">MKYSLAPFILRRPWLARLFKPAATWYVNAAGYRQLGLKYDDLLEEENEVAQKALKRLSNVESYERIYRIRRAVQCSYQHKLLPKDQWITTATDKPYLQPLMEEVASEKAEKNELDSIAVVRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0Y0</accession>
    <name>S0E0Y0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428424.1">
        <property type="nucleotide sequence ID" value="XM_023575205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0Y0"/>
    <dbReference type="STRING" id="1279085.S0E0Y0"/>
    <dbReference type="GeneID" id="35396848"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03366"/>
    <dbReference type="HOGENOM" id="CLU_010837_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160:SF19">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="837" mass="93115" checksum="14E6922C89BF0DC8" modified="2013-09-18" version="1">MSGPPPPPPPHGGVPKGSGLPPGKYDIFVIPEHSSGGGFLYLPSMQPNVNSFAAGFASALILVVLGQTLAPAFRTWWEGFHGLGNMAMAMLVVGVGFGAWALGRFQNQDKGFPGSGGGFSGPGNSGRDNQGGWSSGFRSANAGAPPPPPPHGTPPPPPPHHDTPPRPPPHDGPKTSWHGSPHSERPPPQPEPQPTSRDEPEPPPRPPPQARPPQPQTPPETPPPKPKSKKSKSKPKDPPRDPPREPSPPPKPRAETPPPPPKPKAKPEPKPEPKPEPEPEPEPAPTPKAEKSEREKQKGSWEKAREEMRKKEEERKVREAEQKRREEAAKRLAELRAKDAKERQEREKERQRKEQEARDKKERLEAEQRAKELAIKLEEERRERERLEKEAKEAREREAQREKEARELEEKKKKEAEEREARRKKFAAEREALRKKEAEEAKRREEEKKQKELEKQREQERLEKEKAEKERIEREKAEKEKAEKEQAERERAARETADRQRMSYAYSGVGEKISMWPNGRPPAAPKSTTSSTSKPPPSAASSQRKPGPVPSAAKSNVSGVSTENSYRPYDKPKQQPKRRGSVSSLGSESSWAASQTTGRTTPPLSTRAGPYSTKDPDKIVISGVYLFMNQFSKTPASQLISGVGTVTDGLILRVTTEGLFIDDDVRNVPQREWDVKTWTLKQVEVWCPPHCLKSPAASSPAPGTKPNPLLYKMASSRARDRGATQPLVGEEADVFLTEMLRACKTRCRLGLCNRTFRDTNITSSTGQTGEWKSKGLHLLRATNREGKRYLFVIDESESWKISTGLQRLRKSPLAQQLAVSGMAASDARGTLEMLGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1Y0</accession>
    <name>S0E1Y0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430866.1">
        <property type="nucleotide sequence ID" value="XM_023577871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1Y0"/>
    <dbReference type="STRING" id="1279085.S0E1Y0"/>
    <dbReference type="GeneID" id="35401078"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07601"/>
    <dbReference type="HOGENOM" id="CLU_062278_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="261" mass="28295" checksum="AF96A24CBFC1B59B" modified="2013-09-18" version="1">MALCKACQETLVLRLDPEEDVDDEAGAAGPSTSDSSVPDDLELPCGCHFHWQCLLDQSSDVALSLKCPSCTAYLPVNEGGPSVTNTFLSTPPGTAIFTRYTNEGGIQENLDILPSITEEAYLESNPEARPARALHVMCAEGDVGGIVELLRDAGDSIEDLTAFVTYQDPLGDMKNGLHLAIENSQEESLWLLLWLCSTIPESFFPEYARSVAEATGVGRLSVNRERDIRGLRDSQGRTAADLAQQRQGQWGHILQTGLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2D9</accession>
    <name>S0E2D9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to heterokaryon incompatibility protein het-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428919.1">
        <property type="nucleotide sequence ID" value="XM_023575638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2D9"/>
    <dbReference type="STRING" id="1279085.S0E2D9"/>
    <dbReference type="GeneID" id="35406460"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13004"/>
    <dbReference type="HOGENOM" id="CLU_004184_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="54"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="392" mass="45402" checksum="116515840F35F735" modified="2013-09-18" version="1">MAPPNKDEDAYPIAYQPLNKDKREIRLLEILPSTSEGEVNCKLHTVPLTPDLYYTCISYVWGDPNDKEVMIVNGVPTKVAWSLINALRHLKKHWTDIERKSDPELDPSKFRLWADALCINQEDLTEKRDQVGMMADIYSSAAMVLAWIHPSGKVVKKAFKTFEKIVQIAEENVDSDSWDNALPSKFTGLTEIELFRICESLPPWKPSQLSWLCPNGSGIDLLDFVKLLCDPYGAVFNFCRLDFWNRVWIYQEVILAKRLYFVSRTRCIEHSTCLVALYGLMAYMQHLKRTNLVSWKEDNIDMLQSVFSKIWNLLKMRFVFRGIIDGDQDPDFCLWHLGLYFYPDSEASNKLDYFYGLSGVTTSPFAPDYTKSIREVTLEFMAWVLPIWKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E346</accession>
    <name>S0E346_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429209.1">
        <property type="nucleotide sequence ID" value="XM_023575987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E346"/>
    <dbReference type="STRING" id="1279085.S0E346"/>
    <dbReference type="GeneID" id="35406769"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13315"/>
    <dbReference type="HOGENOM" id="CLU_016972_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF42">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="7">
        <location>
            <begin position="77"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="378" mass="42431" checksum="940800DFF0BC7FBC" modified="2013-09-18" version="1">MSMYSSGVKPGEIPPIYDEVMLARKGQEIRHASSSMPWWNPRYWRKRIWAAIIIVILVIVIIIVAVAVERARKNMYPDYSPLSYTLKDTYGGESFFDQFNYFTGYDPTEGFVHYVPEAQAKDLNLTYVSPSTAVLKVDTSVGPNSKPNASTGRFSVRIESKKTYENGLFIFDVKHTPYGCGTWPALWLTDRYNWPNHGEIDVMESTNKAEDGNQMTLHTTGDCSMDVRREETGKTLQKNCNHEKDDNAGCGVLSKPAGYGSVFNKNGGGVMAVEWRHEGIRMWQFGRDSIPSDIKGNNPKPDTWGTAVADFPNTHCDIGTHFKNQSIIANIDLCGSLVYHVWDDSGCSGKCTDLVANNPEAFENAYWEFGTFQVYQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3D2</accession>
    <name>S0E3D2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to dehydroshikimate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430222.1">
        <property type="nucleotide sequence ID" value="XM_023577100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3D2"/>
    <dbReference type="STRING" id="1279085.S0E3D2"/>
    <dbReference type="GeneID" id="35400384"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06907"/>
    <dbReference type="HOGENOM" id="CLU_035063_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF56">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="33"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="342" mass="38167" checksum="FAF7CC96126B9977" modified="2013-09-18" version="1">MVIQYQGSQIPISFASCSIPMKIKASLPDKLGAVRKAGFDGIELSMPDILDYGKLLSGSQPKEDDYDTLADVAKQIRSLTDELGLKIMMLQPFANFEGWKKGEHDEQRKKAFDKARGWVKVMEAAGITLLQVGSSDSEGISSSFDDLASDLAELADLLAEKGFSIAYENWCWATHAPTWKTVWQIVQKANRPNIGLCLDTFQTAGLEWGDPTTKDGLVKASSDEERKTRWEKSLEELAATVPADKIYLLQISDAYKMDPPIEDKKDEEGSRPRARWSHDYRPLPCDGGYLPVQDMLHAVLKTGFRSWLSMEVFDGLEGENTDMNEYTVAAVESLKKLIQVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3R9</accession>
    <name>S0E3R9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable 60S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_07440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431486.1">
        <property type="nucleotide sequence ID" value="XM_023577692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3R9"/>
    <dbReference type="STRING" id="1279085.S0E3R9"/>
    <dbReference type="GeneID" id="35400917"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07440"/>
    <dbReference type="HOGENOM" id="CLU_056222_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="6">
        <location>
            <begin position="239"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="302" mass="34911" checksum="D4DF91EBD66C70E3" modified="2013-09-18" version="1">MVFHKLVKNSAYYSRYQTKYKRRQQGKTDYYARKRLITQAKNKYNAPKYRLVVRFTNKDIICQIVTSEISGDKVFVSAYSHELKAYGIEHGLTNWAAAYATGLLIARRALKKLGLDEDFTGVEEADGEFKLTEAAETDDGERRPFKVFLDVGLKRTSTGARVFGAMKGASDGGILVPHSEKRFPGYDMETKELDADTLRNYIFGGHVAEYMETLADDDEERFRSQFQKYVDDDVEAEGLEDLYTEAHAAIREDPFKKAESDTPKKTKEEWKEISKKYKTKKLTKEEKEQRVQERIQELLQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3S4</accession>
    <name>S0E3S4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_13575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429449.1">
        <property type="nucleotide sequence ID" value="XM_023576276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3S4"/>
    <dbReference type="SMR" id="S0E3S4"/>
    <dbReference type="STRING" id="1279085.S0E3S4"/>
    <dbReference type="GeneID" id="35407029"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13575"/>
    <dbReference type="HOGENOM" id="CLU_034384_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="121"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="356"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT67368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="410" mass="46816" checksum="78F4163DA7060857" modified="2013-09-18" version="1">MEPTTSEGETDLPHQEPSSLSENSANTGDSEQTVTTDSHTRPTDNVPLTEGSNIPQKRPADDEAAAPMSKNALKRLRKQQQWEAGKEERKQKRKDSRVARKVRKREERAALIAQGIDPNANKQQKPPSVNVPVTLIFDCDFEQYMREKELISLGSQITRSYSENKNARYRTHIFVSGWNGKLAERFHQILDDKHKNWKGIDFVDGDFIECAKQARKRMKDPNDRMVDQLQRSLDNKIPWARDEKDPLPLPDPEPEPSPEYQDIVYLSSDSPYTLERLEPNTSYVIGGLVDKNREKGLCYKRARERGIRTARLPIGQYMVMQSRTVLATNHVVEIMLKWLEYENWGDAFMSVIPKRKGGHLRDQRGDSGEAEEAEGQGAEELEEEDQEIKDPDAEETTSQTSTPEVEAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3T1</accession>
    <name>S0E3T1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_07099</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430402.1">
        <property type="nucleotide sequence ID" value="XM_023577313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3T1"/>
    <dbReference type="STRING" id="1279085.S0E3T1"/>
    <dbReference type="GeneID" id="35400576"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07099"/>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="61"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="146"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
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        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
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        <location>
            <begin position="361"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT68322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="462" mass="51758" checksum="23B2EA63D9115DD6" modified="2013-09-18" version="1">MPAAVFASSVQRSLLSSSLRRVAVSSSAIRPLRASFGAIQTISPFAVRTMASHQKIKVKNPVVELDGDEMTRIIWQVIKDKLILPYLDIDLKYYDLGLEYRDETNDQVTIDAAEAIKKYSVGVKCATITPDEARVEEFKLKQMWLSPNGTIRNALGGTVFREPIVIPRIPRLVPGWKKPIIIGRHAFGDQYRAKDAVLPGPGKLSMVYTPEGGQPQEIEVFQFKNGGGVAQTQYNTDESITGFAHASFKLALDKELPLYMSTKNTILKKYDGRFKDIFQEIYESTYKKDFEAKKIWYEHRLIDDMVAQMIKSSGGYIMALKNYDGDVQSDIVAQGFGSLGLMTSVLITPDGKTFESEAAHGTVTRHYREHQKGNETSTNPIASIFAWTRGLVQRGKLDDTPEVVAFAESLEQACIDTVDIDGIMTKDLALATGKSERKDYVTTNEYMDAVERRLKRTLKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3W0</accession>
    <name>S0E3W0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_07134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430437.1">
        <property type="nucleotide sequence ID" value="XM_023577353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3W0"/>
    <dbReference type="STRING" id="1279085.S0E3W0"/>
    <dbReference type="GeneID" id="35400611"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07134"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="91"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="243"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT68357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="546" mass="59596" checksum="F2BBB4EBD4B1D424" modified="2013-09-18" version="1">MTLTTTTTQTATLDTTPAWKDISDQKIKALNSSIPEQWRIPKDILPPDDQADVTTWPESSGWFTKEELAITSLTAAALLEKLASGEYKSEDVTKAFCKRASAAHQLTNCLAETCFERALQTARQLDEHLAKTGTPVGPLHGLPISLKDNFNLEGLDSTVGFTAHVGDPAKSDSALATVLQNAGAVFYVKTNVPTAMMIAESVNNTFGRTVNPKNRNTTSGGSSGGESALIAFKGSPLGVGSDIGGSLRIPAACTGIFTIRPSAGRFPVRNCRSGMPGQEAVLSVNGPLARTLQDVELYSKAVIDSQPWLVDPKCLPIPWRPAQLPEKLKIAFMWHDGMVRPTPPVTRALQIAKKKLEAAGHTIIEWDPVDQKEGSELLQRMFTADGGQTIRKELERTDEPWRPEMEAYRVARDLSTSEMWKLQLERTAFQNHYLDRWNKAGIDAIVSATTPYSTGKHGSLRHVAYTGVFNVVDYSAVSFATGINVDKDVDKLDASYEPLSPLCKSVNEEYDAELVHGLPVSLQIVARRLEEEKVIAMAKLVHETVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E471</accession>
    <name>S0E471_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431601.1">
        <property type="nucleotide sequence ID" value="XM_023578621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E471"/>
    <dbReference type="STRING" id="1279085.S0E471"/>
    <dbReference type="GeneID" id="35398892"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05413"/>
    <dbReference type="HOGENOM" id="CLU_1069465_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="259" mass="27868" checksum="CF9DA36AD12CADB4" modified="2013-09-18" version="1">MADSLKDQLLALASTGDVNKMRTLLSTSEQRPSQEIIQEALTAAVKNYQYDAVRYLLLKSRSTPLNEEVVRAGVNTGSIPLMQALITKDPSVINMQFDMRGTPLIVACMGRQHVDFLRFLLEAGADPNQEPDAAAYPLALVAALYKDTAAIDLLLKYGAKIENSGALAAAARRGNEVMMRYLLERGARLKTDGTSTATNDSPLRVAVRAGHVGIARILMEHGADPKATDGTGTSAIQLAKQLQQEGKATSEMVEALEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4J0</accession>
    <name>S0E4J0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429699.1">
        <property type="nucleotide sequence ID" value="XM_023576514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4J0"/>
    <dbReference type="STRING" id="1279085.S0E4J0"/>
    <dbReference type="GeneID" id="35407947"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14566"/>
    <dbReference type="HOGENOM" id="CLU_090055_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="177" mass="20152" checksum="23355765FDCBD870" modified="2013-09-18" version="1">MSRFSRYDTDEERLPEGMQRVGYDADTQVYTFRDADGSYWESAPGNQYGQLTKVGEARPEGQETETFLMTSQQQRPKMSWFTEMKPFLNFLMLVILSLVLLFWFLGYKGSSPDERIPIADCPEGTVAYAIHKGDTCWEIANKNGVSVDDLKNKNPDLNCEALKINDRICVPGKKSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4K6</accession>
    <name>S0E4K6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein CMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431899.1">
        <property type="nucleotide sequence ID" value="XM_023578980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4K6"/>
    <dbReference type="STRING" id="1279085.S0E4K6"/>
    <dbReference type="GeneID" id="35399214"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05735"/>
    <dbReference type="HOGENOM" id="CLU_057568_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27914" checksum="FBAE6443323B803F" modified="2013-09-18" version="1">MSTAIKREAEDSPIQPKPKKSKKRKANAPDDELLDTELGLNTLFTKMDNQLLADHLAQKLGRFGTDLSAVEISDMTVSANAIQDTTSWQESRTLDKFPEFLEKVSEDPEDLKKAPKKKGSPHTLIVAGAGLRAADIVRSMRKFQSKENSVAKLFAKHMKVEEQVKFLQNHKTGICVGTPARLMDLIDNGALSLDNLKRLVVDASHIDQKKRGVMDMKDTMMPLARFLSRKEFKDRYGDEKKPLALLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4X6</accession>
    <name>S0E4X6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable arsenite translocating ATPase (ASNA1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_07570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430837.1">
        <property type="nucleotide sequence ID" value="XM_023577837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4X6"/>
    <dbReference type="STRING" id="1279085.S0E4X6"/>
    <dbReference type="GeneID" id="35401047"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07570"/>
    <dbReference type="HOGENOM" id="CLU_040761_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="11">
        <location>
            <begin position="26"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT68757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="341" mass="37409" checksum="525CBBFD95CD74F4" modified="2013-09-18" version="1">MSTAVISAEDALEPSLQSLLDQRSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFSQKFGKEARLVNGFDNLSAMEIDPNGSIQDMLAGQGEADDVNAAAGGPLGGMMQDLAFAIPGIDEAMSFAEVLKQVKSLSYETIVFDTAPTGHTLRFLQFPTVLEKALAKVSQLSSQYGPLLNGFLGSGGQLPNGQNLNDMIQKLESLRETIGEVNTQFQDAELTTFVCVCIAEFLSLYETERMIQELAGYGIDTHSIVVNQLLFPKKASDCDQCNARRKMQRKYLDQYEELYAEDFNVVKMPLLVEEVRGKEKLEKFSEMLVTPYVPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5D7</accession>
    <name>S0E5D7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023579307.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="35399506"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06028"/>
    <dbReference type="HOGENOM" id="CLU_713793_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="2">
        <location>
            <begin position="219"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="390" mass="44233" checksum="8377DA64C247D758" modified="2013-09-18" version="1">MPSFNDNRIRKPYHRSRGLIRNRNLQQSLNINTSQRADKFKTNIFAHAHFSPTQPSRPTWKQEDARLHVEKKDSISFLMSSLHSAADDWECKDCSWQLRNLAAKFYTQFHSNNKGLPTSYPTEMAAREPSSYRRSRHHRRRNSDAVSMRSASSVRSSASSNLGGDVAYLRRCTLTKDVGQDGQSFYGVHQAHLDLSLGETVSVHMRPTDQRRKLSELGPGTIVSAPFHSQNRDEKVSTTNYHTAVSGFGSIYSKYRKMITIEIWGDHAVCLPIYSYNGKGLENRGGMADEYMDIRDIDDDEPEDGDTHHKPLMAIRSEGWPGKNTFICGRSVVKLTEKITHHAFQKCSIEGSLTNSDFQRMYKAYLGLLQSKALEVFGKPVEATIIPSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5I6</accession>
    <name>S0E5I6_GIBF5</name>
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        <submittedName>
            <fullName evidence="3">Related to RTT107-Establishes Silent Chromatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
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        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023579388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5I6"/>
    <dbReference type="STRING" id="1279085.S0E5I6"/>
    <dbReference type="GeneID" id="35399578"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06101"/>
    <dbReference type="HOGENOM" id="CLU_002149_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18438">
        <property type="entry name" value="BRCT_BRC1_like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18439">
        <property type="entry name" value="BRCT_BRC1_like_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="100"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="236"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="338"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="851" mass="94547" checksum="38A96AA32126F3E2" modified="2013-09-18" version="1">MAAADTFAECAIAFVASNLLTPKLIGELSTVLEENGAEICEPRRDGSLPIEKVTHIISNTIDFPQFTEAQAHMIPVVTTQWITFSIARRKQAQIRPFSPDPRMIFSEVVVTCADLPETDKESIAGATMALGGQETKDASKLTTHICALSMDHPKVQVALQKGWKGKVVLPHWFDDCFKLGKRIDEGPYLLPDPEILKKTSADDLKIPSNENLAGATSPTPNYLPLPLPSDGEVVRPPVTVFQDRNVLLSWDLTITDRLSKVVKEIIVRGGGKLVDKVEDCDMLICQYRDGPQYVQAAQAYKEVGNLAWLYWLIVHNEWTSPLRRLLHYPIPKDGIEGFKGLRITVSNYGGEARIYLENLIKASGAEFTRTMRAENTHLITARDSSEKCKAAPEWGIAVVNHLWIEESYAKCEITPINIKKYNHFPPRTNLGEIIGQTFFDEPKLRDKYYPGGPAKLSPRAKRKRAILEAAEENAYARGPAEGVVIGQAGNEDVEMEDSNGGGSEKSAKKTKTIGDATPIRPRRTGKENETPSVASTGSRSAKAKAQERLHGLSDDIALYEKEKKRHAKGGNTIWGGKRAADQAEKTNTKTKQEEKPEDEDADALAKRPIKKTKPSLPDIQMRIVLTGFTRWVGDKNKEDQDRRKLRDMGIQIVQEGQPCDYLAAPSVVRTVKFLCALARGPTVISSTFIDQSLDKGTLLDVEDFILKDNAAENRHNIVLETSVARAKANRGKLLVGVPIYCTEKIRNGAESYKAIAEANGAIFKIYRARSGTTIRPTTAEEEGNAPPEPVYLLSSGRPDERPLWEKFRDMAYKGNMEPRIVAPDWLLDVAMAQQVRFDDKFLAENFYGNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5K4</accession>
    <name>S0E5K4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Related to polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_14695</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429959.1">
        <property type="nucleotide sequence ID" value="XM_023576657.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E5K4"/>
    <dbReference type="GeneID" id="35408075"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14695"/>
    <dbReference type="HOGENOM" id="CLU_000022_37_8_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="16">
        <location>
            <begin position="8"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="17">
        <location>
            <begin position="967"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="2476"/>
            <end position="2551"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="3682"/>
            <end position="3760"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="13">
        <location>
            <begin position="967"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="13">
        <location>
            <begin position="1122"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2559"/>
            <end position="2661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2579"/>
            <end position="2598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2599"/>
            <end position="2611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2634"/>
            <end position="2661"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="13">
        <location>
            <position position="1000"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="13">
        <location>
            <position position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT67878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="4090" mass="448437" checksum="893357BB77ABC0CA" modified="2013-09-18" version="1">MTKFSKTNEPIAVVGTACRFPGGCNTPSKLWDLVCSSRDVLQKVPPARFNVDSFYHSDPTHHGTTNVTQSYFLDEDVTKFDNSFFGIQPMEAEAMDPQQRLLLETVYDSVVDAGLAMEDLKGSDTSVFVGQMCDDWAQMLAKDWDDIPTYMGTGVSRAVMSNRVSYFGKSLLYSKISSANVVTFDWHGPSMSIDTACSSSLVAVHEAVRTLRSGESNVAVAAGANLILLPGMYICESKLRMISPTGRSRMWDANADGYARGEGFASVILKTLSQALADGDPIECIIRETGVNQDGKTPGLTVPSNIAQTALIRDVYQRAGLDITKPSDRPQLFHAHGTGTKAGDPKEAEAISRAFFSERQPYDEKLNVISIKTQIGHTEGTAGLASLLGTMMAMKNATVPPNMHFETLNPDIEPFYSNLEVPTSAKAWPDVHGSVKRASINSFGFGGTNAHAILESYEPALHNQAAATTEAAPPRLYTPLLFSANSEKALKEALSSYLSFLEERYETNMSDLAWTLHNRRSTLPYRSSVVVPAGSENPQEAARSAILDEIERLTDSSHKLHRSSSVAAPKILGVFSGQGAQWPRMGAVLLESSAWARGKIAELDSYLAELPASDVPDFTLESELLAFKETSRVAEAAISQPLCTAVQVLLVDLIRDLAGIQLSAVVGHSSGEIAAAYAAGFMTRRAAIVTAYYRGRYAKLAASPSSSEIKGAMAAIGTDEADALEFCALEDNAGRITVAAVNAPSSVTLSGDEDAIEEAIAVFQDEGKFARRLKVDTAYHSSHMQAAAGPYLEALQRSGVRFDTEVISEQRPLWFSSTKVDAAPMKRESLSPQYWIDNMVKPVMFAPALECALAHSGPFDLALELGPHPALKGPALESLGSGTPYQGVLTRGKDDVESVADCFGAVWRNLGRGHVNFASIDATLSGRASTPTVVRDLPPYPFSADSQVFWSESRFCAALRQMDEPVHPILGRRMVENSVPGMTQWRNILRAREIPWLRGHRLQGQVIFPGCGYAAMALEAAMILVRDLKDSPTVRLLSLYDLTMDQAIVFNDDSSSVETLVTMKTVESSHDELIVDFVCCSYHTHGLAPAVTSTHAHGRVVARLGAPSADAIPGQTAQDPSRQYNLAPIEIDRFYTELAKHGYQYSPPFKGIVEIERKSDFAIGKIVDQSGPEWEDQVTLAHPGLMDSGVQTVLAAMAAPGDGRLWCLQMLVGIDAIHVNPYFASAARGATMAWEASTTLGEDADSLGEAVGDMKMLSPDGQQAYIAVEGARMRPFTPATSANDSPLFSTWVYGPSEPDGVLASRVNRPQEVADAEIRSADNLDRLSLFCVRRLAELIPAGSRARDEAQEHFKRLLTWCDHVIGLVSRGEHHFLTPEMMNDTQAEVDRLLEEYANSNDFRLTHAAAKALLEVVPANEGNVHEYLTKDNMLNRYYEETLRYEASDQKMYNMMRQLAHIYPQMRVLEVGAGTGGATSHALPAIDGAFSVYTFTDISTAFFDKAEEKFKDYSGRINFKALDMNNSIEEQGFTESSYHVVMAGMALHATGDVEGALRNIRRLLKPGGRLIGFENINNDAVRLGIGMGGFAAWWSGAEYGRPWGPMLTLEQWDDALKRTGFTGVDTHTVGHNQTQPMCLWVSMARDEKVDLLREPLTVVPEKQQSLVVVGGKSLGTMDLVEKTKSLVAPFYQTTNHFRSVEALNDITEDQFPEGSSVLCLTELDEPVLRTVTDPKLDGLKTLWARGRNILWVTKGAASEQPYNNMVVGLARSIRQEYPSITLQTVDLDNATVGDGSWVPSFVARALRRIELLDKWKREEIANGADLNDKLQWTQESEVRVVEKKTYMPRLNINKELNHRFNSIRRIIHEEVDPQSHKTSFSLNASANAPLAAPVIGQISPLRVQPETDAAVPSYELRIRKSLLQALRISTLGYFRLCVGDADGKRVLALTPSAETPATTLKDLTVALPAGASEELFSMALLSTAAHLVAAQIAALVPQQKGSHIVIHDADPLVRAAIMSLFESHPAPSWRVSFTGCLVEGQQPQDLPGKTTWLVQEMSSRAIRKVLPALTTSSLLVDFSAPNSPSAIVASAMVECLPWYARTEKSLIRNRVEVRPGDLADAKAALQAAWNKASSMVIEARDRETIPLNHIEAFTAPTGQSLHLVDWATTSVPVRVHPLDHHTNIFRSDKTYLLVGLSGEMGQSCCEWMAAHGARYVVLTSRYPKVDQRFIDNMEQAGVTVVPRKLDITSKESLHLCYQAITRTLPPIAGVANGAMLLQDVLFKDMDAANLNKVLAPKVNGSVYLDELFADTKLDFFLMFSSAASIVGSRGQANYAAANMFMASLVNNRRKRGLAASIINISALIGLGYIERQKIYDASFFKDIGIANTSAQGLHQLIAEAILAGQRFDPDEDIEGGEISQGIMPQFSDDEHKSFFIHDSKFSNMLIERVDGDADVDASGNAAAVSLSRQLKRVTSKDQALRIITDAFTLKLKKMLRIPAETDVPESLALVDQGVDSLVAVDVRSWFLKELDTDMPVLKILGGNSILDLASDALERIPKALLDLDRDDDEASNEAQPDSDKKLTESPTSSSSSDVVTGDSDAVSQSSATDVSTTAKSTAGADTASIPPSLNNMKNNNGSNDRHKRELEDEVAKKRRADEEAAAAKRREEIVKSSSEIVDEMSLVQSRFWFLTTALEDKTTFDVTISAHLKGRVDVGKLERALEGVAKRHEILRTRFFFGGKSLETPMQGVLSKPTVHLTSRDINSKEDVEQEMEWLHSHPWNLGDWETIKLSLLSQSDTEHWLVLAFHHIAFDGYSLEIFWRDLAKAYNANGLIPTLPDAKQYRAYIAKQRRQNLSKPFEWRKAIEYYRKLIMPEPEPLPLLPFAKVSHRKLLENYSCYNAEITLEPSEAARVRKLAKANHSTSFHVYVAALQTLLFGLMPDSVDRLFIAMDDTNRFDKDFMDTIGLFVNTLFLRFDRTDYNKLSFSDAVKAARTKTYKALEHSVLPLDVLLKELCITRHGDAVPVAQVLIDYRVSHKEWFRLGDCRAEMGTGRAERQGSDLAFYILDDSDEQNGGSVRVGVEVQSTLYDGEHAEMLIRAYANLLGKVTADEVGAKMTLKSLPPWNEDDLSISLGPTIDGWPDADTLSHRIDTMIHENPTAAALGDETSQLTYEQMGRRIDEIAASLATAGLRESDFIGVFQETGVDWICSMLAILKLGMTYVPLYPPIGMPRLAANIQVAQPQAVLVDDSTADKFDQLGTQSAQMIHVPIAGSSAAEVLIRAQPGQKAMILCTSGSTGIPKAVVHTNRSLKALVEPHAIVQEQDKPSYAARVLQQSAFSFDLSIDQTMLALCNGGCVFVVPNSKRGDPLGTVDMIARHNITYTMCTPSEYSIWHRFARDRLLDCTAWENASSSGGPLSTALVRAFAGLELPHLRVFNHCGPTETTVTNRIELNFADYAEGEKAQMRYVTDVGFPCANYSTYIVDENMKLVPRGYPGEIVVGGAGVADGYLGRPDLTKEKFIPDPWTSSKEWKIMYRTGDRGKLRANGMVDILGRIEGGTQVKLRGYRIELGDVESAILSSAQGVLSDAVVTLRYPEDRHEDHDDDGFLVAHVVVADKSLRRPEVESFLRKIVSKLPLPHYMLPALMLPIDRFPLTAHQKPDRNVIAALPLPAFTPATANDAVAEEGSLESETQEKIAKMWRTLVPASASATITADTDFFHVGGSSLLLIKLQGMIRKEFNVSLRLLNLMAASKLREMAALVNDEVSGGDIDWERETKIPDEWLSVTQVALQKMNGPVRVLVTGATGFLGRNLMSHLAEASQVSEIHCLVRDASTTETSDKATLWRGDLSQPSLGLSDNDLTLLSNSVDAIIHCGANRSFWDDYRSLRAVNVSSVAELIRLALPRRLPVHVLSSGAVKRYGDGHPPVDGSDGYVASKWAAEGLLRDAAKRAGLPVFIHRPAPALTATETADEDTITSDELLRLAKAISLRPDPTGLNGTGHFAPIDQISSRIVDALLQSSTQPPGGIQIIEHAGTKTLSMGEFANLCEQLPELKELPTAKVLQWFGQAKKQGLKQFLTALEVEFSDDKGDTAVMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5L2</accession>
    <name>S0E5L2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to beta-1,3-glucan binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432115.1">
        <property type="nucleotide sequence ID" value="XM_023579244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5L2"/>
    <dbReference type="STRING" id="1279085.S0E5L2"/>
    <dbReference type="GeneID" id="35399449"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05971"/>
    <dbReference type="HOGENOM" id="CLU_019533_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000178">
        <property type="entry name" value="Glycoside hydrolase family 16 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF62">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="131"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT70036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="463" mass="51976" checksum="C5BC2D504FADD833" modified="2013-09-18" version="1">MSRRSMDASGPHEATSTGYRHSIDPGRGSGSGSGGHGGMFSIPEYSSPASESESTSGSGTQIDERNRYFHSRRVKPGEVEKPWLEKTNPKEKWVTILPILAIFLGLVGSGFLVWDGIRSVVKNKYCLVMEEDFSQGLNPNIWTKEVEVGGYGNGQFEQTTNTDENVYVEDGKLIIKATLQDPKLMQKNNVINLLKAGTCTSKVWSNCVASTNLTAGNNSVVPPARSGRINTKKGANIRYGRIEVTAKLPEGDWLWPAIWMLPRQSVYGAWPRSGEIDIIESRGNNWTYKQGGNDIVSSALHWGPNSANDGWWKTNNKRKALHTTYSAGFNMFGLEWSEKYLFTYVNTRLLQVTYTNFKKPMYKRGGFPDVDQNGTRLTDPWTISPNVNAPFDQEFYLILNVAVGGTNGWFEDGKSDKPWYDASPTAKKDFWDAREQWYPTWTQPQLEVSRVLMMQQCNGNEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5U2</accession>
    <name>S0E5U2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432358.1">
        <property type="nucleotide sequence ID" value="XM_023579536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5U2"/>
    <dbReference type="STRING" id="1279085.S0E5U2"/>
    <dbReference type="GeneID" id="35399711"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06234"/>
    <dbReference type="HOGENOM" id="CLU_006646_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1018"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="841"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="874"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT70279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1123" mass="122361" checksum="40F6E52674634D64" modified="2013-09-18" version="1">MSRYVYGHGAAQGYQTSQPYANSANEPYNPAFYHNDAALAEPAHGQGVAEAYEYKQTTIPGLGMRFSQDTANWQPTLPQKIPDGQMDLSNAITTDVSTRPDNNASSHSITYNSLSTMAMDVDRMEDGELSEGELEDIYEPNGIDGPDAEDNGPRPPDPTAAKHHTTENLQNNYDGEKRASNSKQPGRERSGSYSPYLSPREIESNGSENGRSNTHNSSVANNLTMTESGIVMKTTDANGGEYSSSPRPDTKHIDTIISESKKRAEKAILHLWPLNVRYHNYIEEGIDQALLDELFGEMGLDLEANTASQGEAKRPSMSNVAKVPSNALNQESPLTVTSTAAAGTKAVEQMKDKSEERKDRIARLLAAKGSKTAVGDTDIAKPAHPIPLLPGNTKTDKTKSQSEKSKLIQQKMEALIKAREANAKAAPQAHTPSEPHLLPPVTEPSRSQSLARADSVNIDEQTEVNVEIADPATAPSIPGLFLSSNAPSPVPHQRKRPVAAELNENSTAMSHKRPFGQTRESRPFLIDVSDDEDDAEMEIDSPELRPSSIQQPMTPGSRTASFRDHPALPDSASRRAASSPKTAGTPATSANGMYDLESMNKKIEDMKRKIAEAEARKKAKQSGNNSPLPQSGSPSKEGSVDVPTSPAPTVRRAVSTNTEVAQDSPASSVHNSPHVIAKLPKARNQPATARPSLRARVASERLPIVEARRKAQAEQLKHLYSEAARLENEIQKSLAEEERLKEDAAENELNASTPNESELENFQRDSLDMVTNARRASQETNSKETLTELAENEKANLSCDEVVSDASMDEASSIEPTINSEMIDQLPQGELQELENRRAKETTIPGSPSALATRSSITHNTADTSGDPATNGAEEAEDDVAMEEDDTSNEEEDTDDYEPTHVGVRLPGPQSPVSWHSSPLHAPLDHGVLETSDTDMQGMATTTPITQPISLGDGDTESETHREAEVQKAPRVCEKIEKTTFVPYETPLQYFRAYRFHPQYSGSVAGGLRSLTYSNKIDVTKEVCPDQLIGGACPRGSKCQFQHFENMQVPGAIDDQILLQLGAYGNCEADQHDQYVEGLRELLTDFRKRKVKDFDAISNGIIEYRAKFLGDKTKILPLGAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6J1</accession>
    <name>S0E6J1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432384.1">
        <property type="nucleotide sequence ID" value="XM_023579571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6J1"/>
    <dbReference type="GeneID" id="35399742"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06265"/>
    <dbReference type="HOGENOM" id="CLU_158082_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434:SF1">
        <property type="entry name" value="CUPIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434">
        <property type="entry name" value="CUPIN_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10209" checksum="CB6E633BF07554A2" modified="2013-09-18" version="1">MGFGNEYEEQVRAWGFERVFTWSDSPNTHYPPHSHAALTTHLIVEGSITLWYPQEKGSQKQVYGTGSRIDVDAGRVHEVQVGGSGCTMVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6J3</accession>
    <name>S0E6J3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432578.1">
        <property type="nucleotide sequence ID" value="XM_023579807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6J3"/>
    <dbReference type="GeneID" id="35399954"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06477"/>
    <dbReference type="HOGENOM" id="CLU_2722428_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="72" mass="7615" checksum="1A9033AE9631C112" modified="2013-09-18" version="1">MAAPNQFFSLNFNGADPASPFTCPHCQHENPVDASMCKGHKRGKPCCWVVPIVSQAHGNDEDGTSDANGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E759</accession>
    <name>S0E759_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 13, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_05687</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432818.1">
        <property type="nucleotide sequence ID" value="XM_023578926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E759"/>
    <dbReference type="STRING" id="1279085.S0E759"/>
    <dbReference type="GeneID" id="35399166"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05687"/>
    <dbReference type="HOGENOM" id="CLU_122515_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000277">
        <property type="entry name" value="COX6A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT70739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="127" mass="14977" checksum="A2A611998BBF3D04" modified="2013-09-18" version="1">MSAVRFTRAATRATAQLRAPLQRRFASTADNEFIKERQHIKEHAAGTTELWKKISLYGVAPCLIAAGANAYWLWNEHWEHWNHMPPLEERTEYPYQNIRTKNYQWGNGDKTLFWNDEVNYHNKDKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E776</accession>
    <name>S0E776_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable isoflavone reductase family protein (CipA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_05484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431667.1">
        <property type="nucleotide sequence ID" value="XM_023578700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E776"/>
    <dbReference type="STRING" id="1279085.S0E776"/>
    <dbReference type="GeneID" id="35398963"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05484"/>
    <dbReference type="HOGENOM" id="CLU_044876_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF8">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="54"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT69587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="368" mass="40031" checksum="C2E93BB4C24489AF" modified="2013-09-18" version="1">MESHQAQLSSTTATITTTLHSSIFSHLTTIKMAIYAKDQPADFTNSIERVAIVGAGGTVGSHIANALLQAGKHTVTALTRDGSTNDLRDGIVIATIDYNDESTLTAALKNQQLLIITLAPNAPKDTHSKLVQAAAKAGVPYIMPNGYAGDIEQVKLGKDTLLGPIAKANRDEIERLGMKWITVCCGFWFDYSLAGGESRFGFDFDKKTLTLYDDGSVKNSTSTLAQVGRAVAKVLSLKELPDDENDNSLTVSSFLNRAVYLNSFVVSQKDLFESVKRVTGTSDADWTVTHESSRKRYEDGMAQVKRGDMSGFSKLLYARAFFPEDPSDLSAKAQNELLDLPKEDLDEATKDGIALVEVLKGRGERMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7U7</accession>
    <name>S0E7U7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432814.1">
        <property type="nucleotide sequence ID" value="XM_023578887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7U7"/>
    <dbReference type="STRING" id="1279085.S0E7U7"/>
    <dbReference type="GeneID" id="35399131"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05652"/>
    <dbReference type="HOGENOM" id="CLU_084855_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT70735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="171" mass="19924" checksum="1AB4F27F44C307A0" modified="2013-09-18" version="1">MLESQSLRPYLQCVRSSLTAALTLSNFASQTAERHNVPEIEAQTSPEVLLQPLTIARNENERVLIEPSINSVRISIKIKQADEIEHILVHKFTRFLTQRAESFFILRRKPIKGYDISFLITNFHTEEMLKHKLVDFIIQFMEEVDKEISEMKLFLNARARFVAESFLTPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>S0E927</accession>
    <name>S0E927_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FFUJ_08529</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433480.1">
        <property type="nucleotide sequence ID" value="XM_023580759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E927"/>
    <dbReference type="STRING" id="1279085.S0E927"/>
    <dbReference type="GeneID" id="35402005"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08529"/>
    <dbReference type="HOGENOM" id="CLU_012062_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="19">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="18">
        <location>
            <begin position="329"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="487"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCT71401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="579" mass="63858" checksum="EFBFBC8020466810" modified="2013-09-18" version="1">MGKGTDKLYITHSEWSSADAFSPSVGAGASSRNQNASASFRRLPFNFCAASLQPFKNPVCTPGGTIFDVEVISAWLDKHPNQNPVTGESLQKKDLIRLNFARNSESDSLGAGLSDGKGDLIDPVTYKVFTDNTHIVAIRHGTYANVFAWDTVERMNIKAKSWRDLVDDEEFSRADIITLQDPQSAASRNLDQFKYLKDGEQAQLTKEQEDERNAGNINSSALGSLGDKVSRAKAAVEKARKAREQGGDINRSSTALTKPTAANNVIRHSMIKDKKLAANSAAYTTGKAAASFTSTGLTPETSGERALLTDEEYMLKPKRVKTTGYARIETNLGDITIELYPEFAPKAVWNFIRLAQTGYYKGVAFHRNIPNFMIQGGDPSGTGRGGQSIWGKYFDDEFDGPMSHNARGTISMANKGKNTNSSQFFIAYKPTPHLDRKHTVFGKVVENLNVLSKMEDVPTDGSSRPLNKIVIKDIVIFHDPFAEFQKQKQEHERQTREQEKIQLQGGTDDDKTTWTGKRIRNDGTVESTGAGESVGKYLKTATHQNTATTNEADIEDVDTWEEPARKKIKGGGFGNFDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E953</accession>
    <name>S0E953_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_08771</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433259.1">
        <property type="nucleotide sequence ID" value="XM_023580490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E953"/>
    <dbReference type="STRING" id="1279085.S0E953"/>
    <dbReference type="GeneID" id="35402247"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08771"/>
    <dbReference type="HOGENOM" id="CLU_054611_0_1_1"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT71180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="309" mass="35407" checksum="42F940770576E051" modified="2013-09-18" version="1">MAFTLHSHSGEFCPGHAKDQLEDIVKHAISVGYKTIGFTEHMPRYDLRDLYPEELDNPQAALEALPPRHEAYLVEAQRLQREYASQIHILIGFEAEFIRPNCAAHVRKLAEHPIVDYFIGSVHYVHSTPIDYNKEMFATAREASSRKTEESLYEDYYDLQYDMLKELRPRVVGHFDLVRLMSEDPARDVRQWNGVWDRILRNLALAREQDGWLEVNSAGLRKGLAEPYPGSIIAEEWIKLGGKFTFCDDSHGIAQVATNYPRTVTYLESLGVKEVWCLKRTPNSGVDGTMRATVEEVSVPLSAFREHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9K2</accession>
    <name>S0E9K2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433645.1">
        <property type="nucleotide sequence ID" value="XM_023580963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9K2"/>
    <dbReference type="GeneID" id="35401823"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08347"/>
    <dbReference type="HOGENOM" id="CLU_089016_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="287" mass="33981" checksum="7C31AB9F1F79FB15" modified="2013-09-18" version="1">MAQFDDLPPELRAAIWGYTLPGDENAIYIYNPEWANEFFPSSRPQGPNSDDNFNPCLPARIQVPIPGVYNVCRDARPVVHRWMAKNNLEWYDRQETSERILVRPFDVQRDILYVPQDEWDMFEGFVNSDELDPEEHQNLRNNIINLAVSADSMSRFDNVEHIARLMLRAPNLKKIYVIFNDLPRVKKITTYLPNGVEWWTDISVQQRCEIASQPKPHEKVHIHRLDRHNQLRLFEKVYLRDPQKQMDSIWRILVERFPDIAHSVTKELKVPRVDVTIMQVPTWDIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9Z7</accession>
    <name>S0E9Z7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433820.1">
        <property type="nucleotide sequence ID" value="XM_023581177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9Z7"/>
    <dbReference type="GeneID" id="35401631"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08155"/>
    <dbReference type="HOGENOM" id="CLU_532143_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="512" mass="57730" checksum="5C73BF98177FD78A" modified="2013-09-18" version="1">MSYHVHTGYWRNHDANLQNQFIYTVSDTVAMILTTVVGAFISIVGSRAWVIVRRLAFWFCHKYGPTRTNASPPGSLDQPGLDMPSIDIPLESLEESSINSTDPRSVGGDVFEDFDETDISQSDALLAWMPRWRKNQNHKALSDSQWLRSFLFLAACIWAVFCLALGLTVVYISTSLGDERPTVQSEWTPCCGRLGIQQTLYPAAEDKEAERYVLGCKEDHDNDLRDCGSFWSGRATPEVVIHNTSCPFEGQICSEKAYPISIQHNMTASSFGYNSPSKATLHHRLTCAALDLSHFIWPKAWENGKRLLSFQNIDLPDDEWIKQYREHSVWLETLNGPNKLSSNHSGWDGHLHFGEEAPFPKDMTLVLIPAGLPDNLLVAQRQLDPRLRHPNATTFIVLVFPGQNVFLGAGPMTDPMFHASRQNHVGESRFGQWLPDHEVNGVGCAEQYKLCSDDRHCSGWRSTFESEFLANGQSFSPAGELSSPLQDQAEDQLLLFYNAFKYSSTKQFLRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAF8</accession>
    <name>S0EAF8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433943.1">
        <property type="nucleotide sequence ID" value="XM_023580578.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EAF8"/>
    <dbReference type="GeneID" id="35402168"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08692"/>
    <dbReference type="HOGENOM" id="CLU_002444_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1310" mass="142609" checksum="568679AB99A6C2CD" modified="2013-09-18" version="1">MPENDSPAREPSTRGRGRGGRGRGGRGRGGGRGGSTAALSKATTAKAGRGGSRRGRAKNFADSRVQAAYERQRHLKANYQAVAHALKPALQELAERTIDDALQNPDKYKLVQEFIPAMEELQANLDAKLAEHKRRLDRDLQLAQHLHEADNYVAEQEFQNGLDEIEEQFYESQENRARILNSLYDKNLPVDIADDQYEYKVISDEHYDEEFGIYECYQDGHLVPYPSRVQGTSMWRKGRENEAAATAAVTTATTASSKGRGRGRGVNKRRAQDQPDGQPTPKKNTRSNADDGASVAAPAPAKGLLASAAEAEATPEGTPAESESAPGTPEPPALVNGITPAAAARAQSKLPARERSPPLPKNMGDEDQWGYRVYNQKPSMREKGINSRLYCPKTFEFNDWEIGFRDSTNDSSKGHTHAKRGKYLDTPNSNGLHVDHWCNGYDFSTTVPEDFDQDTVKRFGVHPKYGVIMKDAPVPEVEKTPHVMPGKPVVYIANPSGRIAHASRSFLKTTNHRRSDDSPYRAKIGASMRRFCKLEEVDPEEISISEYVRSDEVLRSRSLGTAAKELEARPVVSRVASESQEPESEEQEPEREDAEAPQPETGFTNLAVLAYAGAFLETEESNKAPKPAPKPARYDAIRDVFTDSKPAPAPTPDTSSSVGLDALATLSNVVSTSNESAAIRETEAVYDTAPATELAMSYEPASVPEAPPMLEPYGTQEQSSYRDAAPNGMGPGPVPSHGMLEHDPRSSVSQTNELPPVTPSQAPIDPRYNPSPVEVPQGYMHQPRAHMSMQPSGPVHGHPGETMAYPPIQEHNVSQHPPVRHPDYAPPHPSQGPPVQDQGAYLSHSSYPNTDPRDAQMAAGRPIDPGYSPRRMSIYGAPEPSYSRAYWSQPPPPGPPPAGPSNAPPGPAPGPLSSHYSSPAPPSARIPFSHNASAEPLPPLRPSRGRNQSLQDEALLEPSLRSSGSYYPPGPPRSYHRGYPGPEPHGQPPLQPIATDRILPNPQTAGQGYMTSPHQGYAHQVLSPTYANPPPMPPHMAQSPQDNPQGLPSSIHGHRSTPSGSSDAGNKYRKLQPAPVPAHRAWPNKPELKTIPYDHKETGSAAALPSSGPTQIRGWSVNQTRKRSGKERDEQAKPARPYKSVRFVEPAIGVPPTAQKLNKRKHSDTQPDDDVVAVEPSAKKSKKSDDVAVVIEEDDNSLKRRLRPRKPKTTEAEPIATKAAPAKKPRVAQSRKSKTVEATKTKETAAKTKIKIVRSSTSNKTSDQDVESTTSKGNLSSANEPRVKGESSDDVQIIKSQRKVITIDSTDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAH3</accession>
    <name>S0EAH3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_08326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433958.1">
        <property type="nucleotide sequence ID" value="XM_023580986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAH3"/>
    <dbReference type="SMR" id="S0EAH3"/>
    <dbReference type="STRING" id="1279085.S0EAH3"/>
    <dbReference type="GeneID" id="35401802"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08326"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT71879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="202" mass="22425" checksum="300C111FCF55A2F2" modified="2013-09-18" version="1">MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTVKLQIWDTAGQERFRTITSSYYRGAHGICVVYDVTDMDSFNNVKQWLQEIDRYATEGVNKLLVGNKSDMSDKKVVEYSVAKEFADSLGIPFLETSAKNASNVEQAFLTMARQIKERMGTTTANNTKPSVQVGQGQGVGSSSNNSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB38</accession>
    <name>S0EB38_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434209.1">
        <property type="nucleotide sequence ID" value="XM_023581522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB38"/>
    <dbReference type="STRING" id="1279085.S0EB38"/>
    <dbReference type="GeneID" id="35407323"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13869"/>
    <dbReference type="HOGENOM" id="CLU_068289_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="41318" checksum="55D8A3154C0C6AAC" modified="2013-09-18" version="1">MTETKFHKPPTSQTASQPNGSPTPSLDAREVKQVNTGQCDPWADHQPNAPIPGCVAPLSPGHDMGSPRLSLEDTEDGDAVDDIQPWEKELAAGEWFRTLVLELTTYTFEKFRIWKERLERISPIKDEISFSERFGPSFVQPATHTQTGDEYDLIREGLVSSSCPSSSAVFLYLACPFYVYDHEQCRECLLTGDLRNIEDLVEHLFQCHSRLLYCPHCYETFESQISRDDHVLEEKCQKRVPSQIFGLSESQKVKLFDVDIESQCIDQQALWFRIWSIVFPDTMEPQSWLLDRDPGLSISMMRDFWNSNGLKYIAQFLEDRRISQENSTKLTDMLYQRVLKDLLTGVMNERTCSWTALAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB67</accession>
    <name>S0EB67_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_05599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431773.1">
        <property type="nucleotide sequence ID" value="XM_023578827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB67"/>
    <dbReference type="STRING" id="1279085.S0EB67"/>
    <dbReference type="GeneID" id="35399078"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05599"/>
    <dbReference type="HOGENOM" id="CLU_035741_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14710">
        <property type="entry name" value="bZIP_HAC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044280">
        <property type="entry name" value="Hac1/HY5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714:SF6">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="113"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT69693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="463" mass="51493" checksum="2AA6A43A506DAF26" modified="2013-09-18" version="1">MEQQGSPASQFFQSPADSLMSAPEDAYTSLFAATTPSAASTVNPMDMLTPKSYNDDSLLPMIKQEEGVVSTPSPSPAPEKKTTKKRKSWGQVLPEPKTNLPPRKRAKTADEKEQRRVERVLRNRRAAQSSRERKRQEVEQLEKRNKDLEAAIQQAEQMNARLMDELAQMRKANGLPPLSQELFSPQTTHQPAETMVSPNATVDPMALSPCLSPVPEESEETLQQEPANETTLEQSENTSPDLTQRPAAMLSDLQSNIGLAPATSDDTLFSCGGSEFLSTSLDTDRYLIENGHLSSPFSSATDEPYLDFDTSSFTLDNSFNDELYNTFINDTDNGISVELQKPTDDAAAILSDEFRIYELENQVSSENPIQQPLPGAVEDAERETEDSRGQDELVRCLSEITLPSRELLVTLLWALRLEEARIQREAGEVLDPETRSPLRVHQPSKKAALSVILEEENNRVQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBK4</accession>
    <name>S0EBK4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">FFUJ_12181</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBK4"/>
    <dbReference type="STRING" id="1279085.S0EBK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12181"/>
    <dbReference type="HOGENOM" id="CLU_029061_1_1_1"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023285321" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023285323" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="497"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="108"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="496"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT72326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="540" mass="60044" checksum="7A6B60643EA081F2" modified="2013-09-18" version="1">MAPTLGFGPGSSKLGSHMLRNSFYTHGRWTNCYSPSASRHMFLASTRSRCLSRPSVSSIRTFASNSGKRPRFSQRLGEAMRNTKIQWYRIPVGLGIGFLGLVQFYKVSSREKERLDNEDGQEGSRAPKKRARIRPDGPWQVQVMSTLPLKAISRLWGRFNELTIPYYLRVPGFKLYSWIFGVNLDEVAEPDLHVYPNLASFFYRTLKPGARPLDQDPHTLICPSDGKVLQFGQIQGNDIEQVKGMTYTIDALLGKNTPAPSISGASGTSTPATSQGDVSEEESLVKQHEEFAQVNGISYTLPDLLTGTGKQAPSAKDESMPASPGTVSEVRAELALGERPWYDLISPDNTTSLYYAVIYLAPGDYHRFHSPTNWVVDRRRHFAGELYSVSPYLQRTLPGLFTLNERVVLLGRWRWGFFSYVPVGATNVGSIVINFDKELRTNSLLTDTAADRAAEEAAHRGEVYHGFAEATYEAASPVLRGHALRRGEEMGGFQLGSTIVLVFEAPSGKTDENNRHVGWDWAVQKGQKVKMGQALGRVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBR1</accession>
    <name>S0EBR1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434417.1">
        <property type="nucleotide sequence ID" value="XM_023581771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBR1"/>
    <dbReference type="GeneID" id="35405651"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12195"/>
    <dbReference type="HOGENOM" id="CLU_2184193_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="109" mass="11925" checksum="D1A496D18AC79D05" modified="2013-09-18" version="1">MEDPVMNPVPKRGHGGAYVGHGNGGGGRVRLGGLFASRIGEAERAWQLYQLTGILTTNQRLPKRQGQRSETQELRDNVLGAADRWNVPMWTPPQFEPNSDSAGAEVFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBX2</accession>
    <name>S0EBX2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor cwc15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_08643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433376.1">
        <property type="nucleotide sequence ID" value="XM_023580632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBX2"/>
    <dbReference type="STRING" id="1279085.S0EBX2"/>
    <dbReference type="GeneID" id="35402119"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08643"/>
    <dbReference type="HOGENOM" id="CLU_068312_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT71297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27238" checksum="8054250034142CB0" modified="2013-09-18" version="1">MTTAHRPTFDPARGKEALRGPAYHQHLLPAHTQLKYRQAGQGGDADGPTRDLAAELLAAEAAHFTKKSGALALVDDADEDDETSVSNDAKRALPSADGEGEDLEAKRRRILAETRNIDADDSEEDDDDDDSEDDEDSDDDSDAELQRELDRVRREREERKKKEEAERLKEEEEARERDIALGNPLLNKQDFNMKRRWDDDVVFKNQARGTEDKGKKKEFVNDLLRSDFHRRFMSKYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC12</accession>
    <name>S0EC12_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_05864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432017.1">
        <property type="nucleotide sequence ID" value="XM_023579124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC12"/>
    <dbReference type="STRING" id="1279085.S0EC12"/>
    <dbReference type="GeneID" id="35399342"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05864"/>
    <dbReference type="HOGENOM" id="CLU_029647_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="16"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="460" mass="51006" checksum="98B23819F8A65036" modified="2013-09-18" version="1">MPKRKRGEPNLGDKLEKHCNDVSKALKAAKGLERQRYSKRLHEDGVEPDKKERLEREVTVLKSLDLHQTARAHLYSSILKVKDLAASTDLPEEIRTGVPKPELTPEEQAALHNVTSALYNRELVKQAITRAIATFCQALDIPLPGKAKRVRKSKKGEKEEQPSDRIEGEPKSEARAAKEDVRASIEKEVELELEESEFEGFSDHDDPVQEPEELDSEDEANEEKSMSKYDHLLGGSSDSEDEDDFDDERFERFKGKEKVNLDDISVSGSDAAPELGSESEDEEEELSVSASPSPPPAKKKKSKDKASAPARPRESTFLPTLMGGYISGSESASDVDVAPAKKRRGQRARQAIWEKKFGNKAKHLQKPAWETQRGRDSGWDGKRGAVEPGDGPRTPWKKGIRNPLAARQGGSEGAESKPEVKRPPPKKDDEGPLHPSWAARKQAKDAEKTAAFAGSKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED70</accession>
    <name>S0ED70_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434912.1">
        <property type="nucleotide sequence ID" value="XM_023582367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED70"/>
    <dbReference type="GeneID" id="35406183"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12727"/>
    <dbReference type="HOGENOM" id="CLU_2722429_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="72" mass="8261" checksum="4646AC9318DD4978" modified="2013-09-18" version="1">MVTEIFRATYTKQDAIEKFLNNVFGEGNATVQWKQGKYNCTLPRHLTEAEKKTMQETLNVEHREKTKNGGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE31</accession>
    <name>S0EE31_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432742.1">
        <property type="nucleotide sequence ID" value="XM_023580002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EE31"/>
    <dbReference type="STRING" id="1279085.S0EE31"/>
    <dbReference type="GeneID" id="35400130"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06653"/>
    <dbReference type="HOGENOM" id="CLU_036110_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF5">
        <property type="entry name" value="BLR2277 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="3">
        <location>
            <begin position="45"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT70663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="311" mass="33784" checksum="3A6067F57B955961" modified="2013-09-18" version="1">MNFYPAPPIIKAEIYLRIPDDKRCLGQESEWRGGFAGSFQHIFLEGPVVDSAGNLYVVDVPYGRILKIDGDKNVRVACTWDGEPNGLVGTVDGDLLVADYKQGILSFSPETGKIGPKLTRKNLERFKGPNDLIVDSKGNLYFTDQGQTGMTDPTGRVYRLSPDGRLDTLLDNGPSPNGLVLSRDERFLYVAMTRANQVWRLPLHADGTTSKAGVFFQSFGNAGPDGLSLDEEGNLFICHPSLGSVFVVDTHGVPKARIVSGSPGINLTNCCFGGPEHKTLFITDSLEGNIQTVDWHCRGAVAAPALKQSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEU5</accession>
    <name>S0EEU5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435278.1">
        <property type="nucleotide sequence ID" value="XM_023567903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEU5"/>
    <dbReference type="STRING" id="1279085.S0EEU5"/>
    <dbReference type="GeneID" id="35403586"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10120"/>
    <dbReference type="HOGENOM" id="CLU_601350_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495906" evidence="1">
        <location>
            <begin position="17"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="463" mass="50458" checksum="8B9935B6A3CC392A" modified="2013-09-18" version="1">MKSTVTLLAITAAVHASPLQRRQDENTHVWDNVETFCNNQAVLLRDAAGAASVWENTTAGNELDIFIAQSWEHELNWLLNLEDNVVGGVSGGPTVGGCGTTEGECRPLGGMNCEDQFNKYGTDKDGNEHILGKTSYWIFQAVEGMQAKFRLLKEKLTSETMVAGFSIPTMVEEFQGNEDQTSDVLKWLAAAIGFGGTLGGNVPVAGPYISGGAGILGGIFSAVADKTAPEDIDTSTISGALVELFDASANQIDATLKLAVGSANSVDDFKALPNPKPNDDWYKSPVAKFFSTGWFLLNEDSIAVDDAIKSITESIKPKIANNVMKAANLRLIADKRVHNREDCGYATGRQWMALRDGEDYCFYIMRYKPFGGNWGESWDEAEEDVYANMAKYNLGNRDSYYRAILDCALSADKQLVVDDLGFNGIPVCFFDLEAFFIDHNDSPECNSNQINKICPPVKATPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFJ9</accession>
    <name>S0EFJ9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="6 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FFUJ_09403</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 19">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="6 18"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435854.1">
        <property type="nucleotide sequence ID" value="XM_023568699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFJ9"/>
    <dbReference type="STRING" id="1279085.S0EFJ9"/>
    <dbReference type="GeneID" id="35402871"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09403"/>
    <dbReference type="HOGENOM" id="CLU_025427_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCT73776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="418" mass="44691" checksum="8402E1A678D94627" modified="2013-09-18" version="1">MSLSNKLSITDVDVKGKRVLIRVDFNVPLDADKNITNNQRIVGALPTIKYALENGAKSVILMSHLGRPNGSPNEKYSLKPVVPELEKLLGKKVTFAPDCVGPEVEEIVNKAEDGAVILLENLRFHIEEEGSSKDKEGNKTKADKAQVEAFRKGLTALGDVYINDAFGTAHRAHSSMVGVDLPQKASGFLVKKELEYFAKALEEPQRPFLAILGGAKVSDKIQLIDNLLDKVNTLIICGGMAFTFKKTLEGVSIGNSLFDEAGSKTVGNLVEKAKAKGVKLVLPVDYITADKFDKDANTGYATDKDGIPDGWQGLDCGEESVKLYKEAIAEAKTILWNGPAGVFEFEKFASGTKATLDAVVDAVQKDGKIVIIGGGDTATVAKKYGVEDKLSHVSTGGGASLELLEGKELPGVTALSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFN6</accession>
    <name>S0EFN6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to putative tartrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12549</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434740.1">
        <property type="nucleotide sequence ID" value="XM_023582168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFN6"/>
    <dbReference type="GeneID" id="35406005"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12549"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT72662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="511" mass="56360" checksum="6841386C47008A1D" modified="2013-09-18" version="1">MTARDSDAERGNGKEPWSKEFEHADAHDAAARGHLATDEHGNPIATFDAEAEKKLRRKLDWYILPSVTILYLMCFVDRANIGNARLAGLEEDLGLSGYDYNLLLTVFYISYIVFELPLNMVCKWIGPGWFIPATSVAFGIASLGTAFVHTMGQACAVRFILGIFEAGMLPGIAYYLSRWYRRSELAFRLAIYVAMGSFGGAFGGLLASGILKLDHFGSLTRWRMIFAIEGICTIGLALIAFFTMTDRPSTARWLSEEEKDLAIARIKSERVGATEVLEKFSWKLARRGISSPVTIGTSTIFLFTNITVQGLAFFAPTIVRTIYPNHSVVQQQLRTVPPYIVGTFCTVTISFLSTRIDKRNIFINLSQLPVIAGYIMFLSTTNPYVRYAGTFLICAGTFANGALSNAQVSANLVSDTARASGIGLNVMLGNIGGLISTWCFLPFDGPNYPIGNGLNLGACSSIFLLTIVLQVYMTWDNRRRAAIEVGQALAGKTDAEIRVMDWKHPGFMWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGA2</accession>
    <name>S0EGA2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to peroxisomal ATP carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_08501</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433507.1">
        <property type="nucleotide sequence ID" value="XM_023580791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGA2"/>
    <dbReference type="STRING" id="1279085.S0EGA2"/>
    <dbReference type="GeneID" id="35401977"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08501"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="9"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="117"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="210"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT71428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="337" mass="36112" checksum="5E22083B6764A1F2" modified="2013-09-18" version="1">MAAQSKPEISPWGRAVAGATGAVLANALVYPLDIVKTRLQVQVKPDPSKGPTSSDEPHYTSTWDAISRIVADDGIKGLYAGMNGSLIGVASTNFAYFYWYTIVRTLYFKSRKTDVHPSTVVELALGAVAGAIAQVFTIPVAVVTTRQQTASKSDRKGLIDTAREVIDGPDGVSGLWRGLKASLVLVVNPAITYGAYERLKDILFPGKTNLRPAEAFLLGAMSKALATIATQPLIVAKVGLQSKPPPARNGKPFTSFVEVMKFIIEHEGVLGLFKGIGPQILKGLIVQGILMTTKERVELMFVLLIRYIKSIRLQKLGKTAEKTAAAHSVAAKPVTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGT6</accession>
    <name>S0EGT6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">monoamine oxidase</fullName>
            <ecNumber evidence="2">1.4.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_09299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.4" evidence="2"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435953.1">
        <property type="nucleotide sequence ID" value="XM_023568814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGT6"/>
    <dbReference type="STRING" id="1279085.S0EGT6"/>
    <dbReference type="GeneID" id="35402768"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09299"/>
    <dbReference type="HOGENOM" id="CLU_004498_9_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="46"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT73875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="439" mass="48049" checksum="FAAA131C6D4545B0" modified="2013-09-18" version="1">MPTSKEGYLWTSNGLTTGLETDSVINGTPESALLDKYDVAVIGTGFAGLIAARNISLTTSKVLLVEGRDRIGGRTWTAKALGEEFEMGGTWVHWGQPHVYSEIHRYNLQGNLKTSAGTADAKYTAYTASFAGPSKLDTKETNQTVQRVADAFFDIDGLTSYDLMPYPHDPLREPVLWKKYEHLSAKDRLDQLSIPQVEKDMFDAMISSFGSVPGSQCGFVEVLRWYALGGHSMAGVFERAGLCKLGNGGMTSLALSILSEYRGHLLFNTVVEKVDQNGNGVTLTTKNCRRIEAKYVISTIPLNCLSDISFNPPLSPLRQEAVKAGHINQGAKIHFKLKQTEPGWFAMASGYGRSPWCFAFSDHNGNTNKNNGTYCIGFGYGGHLTDPQASEDISASFKEHIKPDADIEANMELLGTWPGYESLAQGASETSWKSILCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHJ2</accession>
    <name>S0EHJ2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435395.1">
        <property type="nucleotide sequence ID" value="XM_023568037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHJ2"/>
    <dbReference type="GeneID" id="35403465"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09998"/>
    <dbReference type="HOGENOM" id="CLU_355267_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="153"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="748" mass="84888" checksum="ACA09BB93B094722" modified="2013-09-18" version="1">MEVIGTVLGLLPLACELMKSAQHLRVRLEAEHKNYLRSLRELNHALRIARTQISKENRMISCDVGKAVDLANETSSKESLSFCLDQAIISLEEAASLKTFRQSLESEPANTDTEKWDRIWRKLFPATSVNRFDLTKIVDPPFYDFGDSPRSIFDEAEPIKSGGWSEVSRVKIHLDRMHGYGDGEGGKATFAVKKIYSGTYQQYARERDALRRLSLAQSPHPHIVPLLASYRVENKYHLVFPSADCDLAMFWRNQPRPSIDKCTLEWFGGQMRGLADALYTIHGGNDQERKLSGVHGDIKPENILCFGSNDSERWPVFAITDFGSSYFLTPEEKDIPKGLKHTPAYRAPEIDTTTLGGITQAYDVWSLGCIFAEAIAWFYNGKAGIKKLILARIDEEDNSPNRDAFFQLQYDKRNGLTAKLKPGVHRLLISLRENSRSSFFIDDMLYIVLEGMLKVNMSERMSAREVLDALTQMCNKLESDPAYSEPRGTIDVDVEMVHTQNVSQRRLDNTVDANYYTNTTTQSLSDAAAVKAQDGWTEHLFRCHLQKKHKGKHTCRRCDTSFETDELLLDHQHQETPCPKRKSEAVYGMLSREQAARLRSLKRKSSKESEEDRWFDIYRIVFPNFNRMLENISPYHESNNTSLSTINSTTSNGISQYKDYLRNRDAEEYAAKLAENGIIITLDAASKLLELQVKELGTFDETMRGPVRAYEIPIDAGHEKTGGNAPSDLSSSSNLMGQLHLLERFGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHK5</accession>
    <name>S0EHK5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable DUF803 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433947.1">
        <property type="nucleotide sequence ID" value="XM_023580720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHK5"/>
    <dbReference type="STRING" id="1279085.S0EHK5"/>
    <dbReference type="GeneID" id="35402040"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08564"/>
    <dbReference type="HOGENOM" id="CLU_012349_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="399" mass="43012" checksum="8D612D58DC8020A4" modified="2013-09-18" version="1">MIEDKYIGLALAMTSALAIGTSFVITKKGLIQAEERHGFEGDGFVYLRNPLWWAGIATLGLGEVCNFAAYAFAPAILVTPLGALSVLIGAVLGSYFLNEELGTLGKLGSAICLIGAVIIVLHAPPDEEIETVDEILHYAIQPGFLLYAFAVVAFAVFMIYKIAPVYGRRNALIYLSICSTVGSISVMSVKAFGIALKLTFAGHNQFSHPSTYVFMILTAVCIVTQMNYFNKALASFPTNIVNPLYYVTFTTATLCASFILFSGFNTNDPVNTLSLLCGFLVTFTGVYLLNLSRGDPHGQRLTAGRGGSDATGTDMVSGLQTRLSMQARRSGDPSRHSMSSQRGDREGLIRAYDEEEAAGFALTDLASDSDEDVRHANGNGKASYDENIELDNRHKSGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHL8</accession>
    <name>S0EHL8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to C6 zink-finger protein PRO1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433957.1">
        <property type="nucleotide sequence ID" value="XM_023580913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHL8"/>
    <dbReference type="STRING" id="1279085.S0EHL8"/>
    <dbReference type="GeneID" id="35401868"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08392"/>
    <dbReference type="HOGENOM" id="CLU_021380_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="572"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="719" mass="80962" checksum="2DEED417BBBACD18" modified="2013-09-18" version="1">MAIESSFAFSQSERNLAWCDNHSISLESRNSMVPPSPLPMDSLWMSSAATANQPQPGQISPLSAGLDNSSAPTMVHSASSSCADSWSTDYVDRDDVEMDNNWEQGSDDILTIPKLEPVEDDLNMDDLKAAPLAPASMDSAKIDPKPKRPRGRPRKHPLTTAVSASKVTKGRSKTGCITCRKRKKKCDEAKPRCMNCEKNAVVCEGYHEKQIWKSGKEKAEEERLRQEALPIITMQPIFHGVETVEDKVFWKHYITHLSNVLTVEGEARNAFKDIILHLANEHQGLMHSILAVSSKHIDWDTPYGAKLLADHPQSSREALQQRADYHHDESMKRLYEDMGRPLDKDDPEYKTILSARYGQMLCLLLQTRADGNPRGEHRVHLQAYQTLIQHSPPEDPALYTFITEFFQYHIFADDLFWHPENMTARLSSEDWEPVAPIQPPRLIGVGDGLFQYLSQITTIRNTIRANISAGVDPVVDYTSLYQAAEIDAAIREWTPNWPWGDSRDRVGLLYKQMMWVYLFRTIYPPSVSSMRRSTFSTLPISASTTVAPPPPPPRRASMMATVSRGNGVTGAADVHMASSCPTSRNPSRTNSMHEQDSSTCQERASSPPPSRRPAYHDRRITLAVEESLTILESFKPSDPSQTLLLIPCLVIGTACFEPAQQERIHTALRAVRGYTGLRNCERVMELLEKVWACMDQGDWVSVWDWQGVARRMRLDFSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI81</accession>
    <name>S0EI81_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to nitrate assimilation regulatory protein nirA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_10784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436799.1">
        <property type="nucleotide sequence ID" value="XM_023569606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI81"/>
    <dbReference type="STRING" id="1279085.S0EI81"/>
    <dbReference type="GeneID" id="35404248"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10784"/>
    <dbReference type="HOGENOM" id="CLU_011581_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="750"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="838"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="750"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="866"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="892"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT74721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="972" mass="108668" checksum="34A0A8BF4F1D59A7" modified="2013-09-18" version="1">MPPLGTLHFPANTGRCSFIAIQIIHISQTGPIHKPTSIGREKDGIQWITNSISATSGFLPMHTSLKHVFNANSARPSPSRKRLRGARACSSCRLKKIKCSATLPACVACRQKDIRCIYPPLKRYRRAPEGYLFDETTLEEEEAPQPESSFMEREQDLQSVSGNSTSPPATDLAEQQQQQQKEPEEQQELEHDHQHDLVIGQEHELEHEPQQQDEADQRLEHQQHQPQRKELPWQRQSAGHPERYEETATIPLSSPTGSSVSWHPSSTGSVARSSGYSGPSRGQLDSLLDVFFKFIYPMPSYGFLHPETTRRRCRSFDVHRALPASICAVATLYLRREVDLDLNHRLDSSRRTLNNKVASAEDTGTWIRMAEESIWRSLESPSITKLQALLLVIHYYIETELFQRAFMLTATAARFATTMRLNYERHDLQPVAREVRRRTLWSLKMVERYFSIGLAEFDSLPMEVIYIDVPCSEEDFMAMANGHEIHVTGKDQVDGEHQNYRGDGGTYGLVMQLEAIRCDIMKLSRKIALLETPLCNLTDLFSHHLQTLACMEKPAPILEALLSVDGALQSPGSCSNGDGSISRWLPRLLLAHISWHQAHCDINRILLPGYSEAAPAAVLVGHDYQAFLDAEAQCLHHAMRIIYILTALNQHSTQHHVLEFDTAICAYHATRLILFISRFGQGPARPSPEFAVSRAELCLAALKRFFRFSALVSPIIRELEESITIFSKQQKNKRNLPSDQSAAAANTTPFAGTLSDETQPGFSGTTANEICTPDSSPATAPAINGEPGEGQTLQSEIHHLSSLQSQNRSDGHFSEAVRARQRLAVHSLLRRAELSNIEREDEEYQSSHIDEVSPGSDAPRHPAFSTRDNQQSPSARYNHGASQEERPRVVGASTATADTTAGSQSAKPHPKTYSITNNQPTKDKPRAHTAKPHGQEPTSTRSPAVPGLFAWWAPQDWAWLLEDQLMELGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIH3</accession>
    <name>S0EIH3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_10492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436518.1">
        <property type="nucleotide sequence ID" value="XM_023569281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIH3"/>
    <dbReference type="GeneID" id="35403956"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10492"/>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="60"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT74440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="525" mass="59354" checksum="A5A87E5F31D4D3ED" modified="2013-09-18" version="1">MATLRNPGSQGYVPLADASPESTEDHVVFEPVKTWKGYIWDTWELPQDQRRLLFKVDAFILTFASIGYFLKNIDQTNINNAFLSGMEEDLEMFGNQLVTSTSIWTFGYVIGQIPSNLLLTRVSPRWVIPSLEVGWGIATICTSSVQSYRSLYVLRFFVGFFESGFYPGIHYMLGSWYTPREIGKRAMLFWLAGSVGSMFSGFLQGAAYTNLNGVHGRAGWRWLFIIDGLITIPLAIAGYFFFPNLPQDGKRTWWTTEEEHILSVKRMQAIGRAGKQPWTKDRVKKVLSSWHTYHLPLLYILWNNGNPQAAMGYWLKSFNDKPAPVPGTSFTVPEINNLPIPSTAIFLVMALAWGWLSDGPLQGARWPFIYAGAILIIIFNILLLNMPLYSNVDGRKVVYWLSKIGHGAGPLILSWINEICSADTEKRALIVAIANDLAYVVQAVVPVFMWKKTDFPAARKGYTYSTILQVLLILETAFIQLLLWRDRRKPVRSRGAESPPPLIYSDEEEGEDGNKPGEPHFSHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKC5</accession>
    <name>S0EKC5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to TAM domain methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437499.1">
        <property type="nucleotide sequence ID" value="XM_023570377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKC5"/>
    <dbReference type="STRING" id="1279085.S0EKC5"/>
    <dbReference type="GeneID" id="35404936"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11474"/>
    <dbReference type="HOGENOM" id="CLU_010595_7_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="341" mass="38461" checksum="C5A6FA146526202C" modified="2013-09-18" version="1">MAEPVTTTREPIEPIAAHERAEEEDEFETSDFDSATLSSSSTSLNTSIYQHAFENGRRYHQYRHGTYPIPNDDAEQNRDDMKHAMMLELTNGNLFFSPIVQNPQKIIDLATGTGIWAIDVADKYPSASVVGVDLSPIQPSWVPPNLKFLVDDIEDEWMHGGDFDFVHMRCISPWLKDEVKVLRQAHDHMKPGAWIEIQELDARANCDDGSLAPDAPLAKFFDTAEQAVASFGMKFRAGENLREPLEKAGFTNVSCKVLKVPIGTWAKDKKLRLIGLYLKTAVSDMFGAMAAKPLRKILEPEEIEVFLADARKDLDNVNIHSYEKYYFWMGQKAAEESGFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELT0</accession>
    <name>S0ELT0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437598.1">
        <property type="nucleotide sequence ID" value="XM_023570492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELT0"/>
    <dbReference type="STRING" id="1279085.S0ELT0"/>
    <dbReference type="GeneID" id="35405040"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11579"/>
    <dbReference type="HOGENOM" id="CLU_027149_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="92"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="479" mass="53081" checksum="D3FAE761492AE41C" modified="2013-09-18" version="1">MAWGDLPVEGRTLDPLNDDLRHGLTAVTVLAFISFFSASTLFFYLVYKLTTWSLFIKSQPSGHFQHTTGPIQRAIDFTLGIDGIFAENDQDANNKADGNVPTAPRRPNQFLVLIINLLLADMHQGVAFFLNVAWLRNNAIMVGTASCYTQGLFVSLGDLASSMFITAIAVHTYLAVVKRRQTPQRVLYAMIIAIWIFVYAISLIPIAATRNGAEFGGFFVRAGSWCWMNRKYENLRLFTHYLYIFLGLGTTSVLYLIIFFHLRRQARFESSGSPSQADTMQLQLSRNPAFLIYPVIYVMCTLPLAAGRIATMAGASVPNGYFCFAGAMIASNGSFDCLLFGTTRNTIVFASKYDISSDDVGLSTFAFLKTPSRRFGNTISIQGGQQADENVAGGWWSWPARVSGSENRSRKGMTRTISQESLRGPAIQMDTVTSVVVEVDDSAERDPRYPDTAASSNPSLRSAEKDYTRTIQRSMDANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMK8</accession>
    <name>S0EMK8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to ARO80-positive transcription regulator of ARO9 and ARO10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438087.1">
        <property type="nucleotide sequence ID" value="XM_023571079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMK8"/>
    <dbReference type="STRING" id="1279085.S0EMK8"/>
    <dbReference type="GeneID" id="35405565"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12105"/>
    <dbReference type="HOGENOM" id="CLU_007201_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="660"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT76041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="760" mass="83812" checksum="62071C8657267096" modified="2013-09-18" version="1">MESPDHSSSTRQFKRSYVACVSCRARKSRCIIKDNPPCAKCAREHRECRFDRRPRAPKHRDAPKWTRGNVNAVDDAPAAQSVQAANHSPSRELGFNSSPNNTNHPLYNRVQSTLVTGTNDALDFLSRAAGQHSIVGSVPSQGHPSASNVQSDSPKVVSGGSNGVGFTITVLSEPDDACLDMWDKCRFVRQGWFTAQEAVTYIDLFFEKLAPLSPVALDQFRSHASHEHLVYREAMLCCTLLMISSRFFTLPGAGGTSRSHYVHQRLWSHCEVLIRRIVLGQEKTSTSQTRTIGTIESLILISDWHPRALHLPPETDGWDGLLVTPGYDRVNRKHINNEAPLIRWREDVFEPAKRANRMSWMLLGMANNLGYELGILSGQTGHLVHGEIPRGRRAQKILYNYLTQTATRLGYPSVFPESISVVASRLSMQETDEPIDQSWMSYMDLSLELTQLSRTASSMFFHSAAHLQTQVLGDHYVDLLEHFSLSLFKWQDKFNSMSQDLASPLKDTLLVEFHHTKACTGAISIQAVVARACSAGFTAATANSDEALSAFITTKDAKFLQEVVSDTKKVLRIATTSGFRDHLPFAPARVKISVISSSVFLLKALSVGSTHTDVSDALYTLDQCTSTLKQCPADDMDFAFRYADLIEKHTAQFRAHLTQSRGLGSSSHSGRASIPRNASEVETGMDGTSSFLSGLDSQQLGDDGSMMNFDVGDTWGSLPFDSSIAPFGEGSDQVALGLDVDALNFLWSLPELVQGETGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMV3</accession>
    <name>S0EMV3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-gulonate 3-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-gulonate 3-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_09429</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.45" evidence="8"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435831.1">
        <property type="nucleotide sequence ID" value="XM_023568670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMV3"/>
    <dbReference type="STRING" id="1279085.S0EMV3"/>
    <dbReference type="GeneID" id="35402897"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09429"/>
    <dbReference type="HOGENOM" id="CLU_009834_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="14">
        <location>
            <begin position="10"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="197"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT73753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="333" mass="36435" checksum="82D0BACAA6FFBB3C" modified="2013-09-18" version="1">MSDTQNKEIIALIGLGTIGLSFAALHLRYSNANLRLYDVRSDLKEHIESLLPVYLESTKKENSQNDLTVEKLVADGRLLVCSSIEEVCSGATIVQEQGPDSVDFKKSNWAQVIKYAPSNAHLWSSTSGISASRQVEDLENKTRVLVVHPFNPPHIMPLIEVVPSPHTDPERTQFAIDYFKNLGSGHRPVRINKETQGFVGNRLAFALFREACHLVSNDVVSVEDLDTIVEASIAPRWAVAGPFKTYNSAGGTGGIGAFLHNLADTMEACWDDAGDISLKGTSATKASQGTDDGDWTDKITKETEQAYGRPTAESLAQRDRNLQKVISAQPKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMZ3</accession>
    <name>S0EMZ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438252.1">
        <property type="nucleotide sequence ID" value="XM_023571200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMZ3"/>
    <dbReference type="GeneID" id="35407613"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14161"/>
    <dbReference type="HOGENOM" id="CLU_1503568_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT76206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="179" mass="20102" checksum="41B91B58CBC95449" modified="2013-09-18" version="1">MADGNARTRNDTFDLAIWPFAIMARYGVNPPTMVDIFKDLLVQCRIVPRSSLLPGPIGWYLCRAEFLRCHYKTFAASVTLHHVQYGTPRWKLKDRIQGCTTPSCRHALRAIITTRTGAKVIMVIRDGVKCKMGAQDRVSNCSEAQAVERKVEQRTVDVNRQLAATGRPGTDAVLAEVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EN31</accession>
    <name>S0EN31_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_09311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435941.1">
        <property type="nucleotide sequence ID" value="XM_023568801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EN31"/>
    <dbReference type="STRING" id="1279085.S0EN31"/>
    <dbReference type="ESTHER" id="gibf5-s0en31">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="35402780"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09311"/>
    <dbReference type="HOGENOM" id="CLU_006586_15_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005146124" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="33"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT73863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="526" mass="57517" checksum="26942AD1422DB000" modified="2013-09-18" version="1">MRIAFLFSFALFAGAVVSATSRSGRTPLARGKQGTYAGIQLSNQVDAFLGVPYAEPPIGPLRFLPPQPLKRSKLVNKVDINNATEFSPVCYQFNYRTVLGAATLPRTEESEDCLTLNVHVPTMAACGRLLPVFIWSFGGAFAEGGGSVPLYDPTNFVAENKDIIVVIWNYRLNIFGFPNCPALDAQNLGLRDQRAALEWLRDNIADFGGDPTRMVLGGQSAGADAGHAMLYSHSKDPIISAIAMQSGSVQVIGAASDNADAEFIRVAETVGCRDSANRAKELACMRRIDAHRLKHAVSNKTVNYFGSPPGGSPMIDNVTLFTLAEYAYRGQKGKFAKVPTLMGIMDAEGDGVSNWDAKAGVNRMLSNILTITLFNCNIALESSYRALNSVPIWRYRYMGVFPEVTPYSWLRAYHIADVPMLLGSQDAITAHYTSSPSEKRHYRNAAQIFRGIFASFIRDPFNGLTDNYDWPTFSPHAKTLMELFPKNSATVLLSDPSTYDKICENPPPIPWELFNSTGATSSGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENR5</accession>
    <name>S0ENR5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437850.1">
        <property type="nucleotide sequence ID" value="XM_023570789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENR5"/>
    <dbReference type="GeneID" id="35405305"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11844"/>
    <dbReference type="HOGENOM" id="CLU_058475_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265">
        <property type="entry name" value="BLL2707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265:SF1">
        <property type="entry name" value="GLYOXALASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="273" mass="30486" checksum="35573D37F0539762" modified="2013-09-18" version="1">MTESNSLQPILDHIVILVSYQTLQELPKRLENVLTVIDGGAHADGQTVNKLIEFSDGVYIELIAFQDDLDPERRKTHRWGELEQNTLVDWAYTLPNEKDFGVIQQRVKEANSEIFYQPPVAGGRIRPDGVELKWSVASAYTTSGKALHPGKAPFWCLDRTPRHLRVPYKEEDGSDPSYTKHPSGAIGVSGVSISVPKEERDVIAKVYDGIHGFTTEEGTWPFVVHSGSTEGKQEITLESSRDQERYIHLTLLGDKGSPKSIEILPGLNFSFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENY5</accession>
    <name>S0ENY5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438045.1">
        <property type="nucleotide sequence ID" value="XM_023571025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENY5"/>
    <dbReference type="GeneID" id="35405517"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12057"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000394">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="485" mass="53343" checksum="234DF6DF3ECE6392" modified="2013-09-18" version="1">MAASKTSTEAVDQKDFLEGPGQVTEHVEITQAVTWTAEEEKKLVRKIDMFLLPNIWLMYLLSYMDRTNIGNAKIAGMADDLKLTSSQYSIILVVFFGKVLARHSRTNQLTLSVGYVIFEPPSNMILVRTRPSLYLPAIMIIWGVLTCIMSVVQSYHHLIILRVFVGVMESGFAPGILLIFSSWYKRTEQSKRFAVFMSAAILSGAFGGLLAGAITGGLEGAHGIRGWRWLFIVEGVATIGWAIIAAFLLLDFPVNTKHLTDRERAIAIARLQEDSVTVRGQGENVGKIQSLVLALRDWRTWGFIFGYMVIVGSSTLSYFYPTLVHGLGYSSTVQAQYMTVPIYAVAFVCTAISGYFADRISNYRGLIIAGWLSFSMITSIAVCVVYNFTARYALLVLMAAGLWASNAISLSFAASTFGSMDAEVRAVALALMNALGNLAQIYGAYLFPSDDAPKYLMGFGVISGMLGFGVCVYIVMHVLVRRLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP66</accession>
    <name>S0EP66_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438220.1">
        <property type="nucleotide sequence ID" value="XM_023571164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP66"/>
    <dbReference type="GeneID" id="35407645"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14193"/>
    <dbReference type="HOGENOM" id="CLU_370471_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT76174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="751" mass="86173" checksum="98F4989DA0682BCB" modified="2013-09-18" version="1">MVARIMLENIQRGNEGDVLETRVEDFNAIDHDENPRRNERCEEEEPAISRGMSQRELPESEGRRAVEEASNIAESPEVRVTSTKADKRSRMVIQKKQIKRKSSASKSKETSKTDEAIELAMLDEHAMIYSLTEDPDPKIQQCYAYYQQRLKEFPIPSHIFRPPCIPCADLFARMDDDTETGHLCEKQGTGSVQVAANVKACKSCAGRRGPCKMNDMPVLLRGISKLMSEANFYFHDTNRMTPFPMGLVYAEARYFELRSRPDVGLIEAIRATQQCSIKIDGVRSQVEGAWCMMPYQIPFPAGPRQTEVSELEKGRKDIEAQAEEIRRLREESSTLNRRKIEWRDKYHDILIRLDSERAAVPDWQTNPIPPPTEEQLDRLLHRTSDGLRRYRCILLLVFSIFLVWLLWTICTICLDWYDASKGIIPFVDLMDEIAENAGFALSVLQLPLYTFVPLQISGALDPLNGVQSSQFAIIEARAPIHEVISNCLEKASLDDRPEDEETKNITRTWVDAYYIRYLDQMRRPEETEPQAALRLTKTYIALIEEAFMTLSDRHPSNFRMADFSQDSLYILEEVPTRMDQLRETIHRFTSSYSAFMEEMSQAIMPLQACREYYKTIEYHKQEASFANQRACDAKYIADLYKLSLSKAVIAESAVNHLSRELKRKYVLRLGGDLSEVAVGLSRVRNKLQRIIRTKDRALKWYRREVKRRENRSGWMMIGGRGGRGSGGGVATGRQGVVYCGVSQSILTYLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPD4</accession>
    <name>S0EPD4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437001.1">
        <property type="nucleotide sequence ID" value="XM_023569844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPD4"/>
    <dbReference type="GeneID" id="35404461"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10997"/>
    <dbReference type="HOGENOM" id="CLU_1959769_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496227" evidence="1">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="127" mass="14049" checksum="59486B8077A926DB" modified="2013-09-18" version="1">MHFTTLLTSAIALASTVASQPTARQAPTANAVIMIVNSADHSRQPVRIPLAQLTTLNYQVTELRLESLNVNIPDIESPKLSDVVCQRYKDKYGVQLGSTEFSHEKPALISTNPVEFGWVLCYHKNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ34</accession>
    <name>S0EQ34_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438251.1">
        <property type="nucleotide sequence ID" value="XM_023571199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ34"/>
    <dbReference type="STRING" id="1279085.S0EQ34"/>
    <dbReference type="GeneID" id="35407614"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14162"/>
    <dbReference type="HOGENOM" id="CLU_048301_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="45"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="432" mass="48459" checksum="CBBA3D277BF5AC04" modified="2013-09-18" version="1">MNELAANLTALRIGRRTHVGFGDETPTEIPFCPPSGNLATKLENTPRYLFRVYSDASAGNNSSEWFKSIDALENNLTDIFARDNAANIAIALNEHLRWEPKSYGDPFISWTTSLLVAIQYAIYKHKAEGAELEAIHLCIIDTTMFPKGVFIRDLDLMEEFYDKVPRGQSIMVKGEGKTWEARGLGDFRHFRNKPHKTYSGVYYFGEFLSQGQINIIDRSSTVTCDKIINNALFTLLPQFQVELEGSKVRWAEAVVESRESFYMGIEPEETSASEFVAATTLALQFRSVWFLPVLANLLALRPRAAQDPGILDRISGFYSDELRYSLSSKDIKIVANKTIPEVLQFGKIVHDINEAFWGESAHNLLRSVEETAGIIRRFVTSSGTTGTSRLLGKSNPAGDLYTIEGKRLQPLMQLLETLNCIMQDLEEGTTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHJ3</accession>
    <name>S0DHJ3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423521.1">
        <property type="nucleotide sequence ID" value="XM_023577005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHJ3"/>
    <dbReference type="GeneID" id="35395567"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02084"/>
    <dbReference type="HOGENOM" id="CLU_058071_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="389" mass="43568" checksum="6761CCDE4871609B" modified="2013-09-18" version="1">MSVFGSQSGLSEQTLSDEDDSNVPMQILAETIDRRKTQNRIAQRKHRQKLKKRIEELELQLECANFNSRSVVPRMSPHPIPMPAPSCSNSSGENMLPHFDHIENLFTKSNGHLGSFWSAQELSSLSGVSLPLGHITTPIPAADVSPLQYQNLTGDNSLNRGIPHTSARCGIERPTASLLMTPTTEINEVLAVPDASRRSSLHPLSDPAELDDPSTPPCSWTMERKIAYIIDCAKTLGFRDFDSVVKTYYTSSFEVMSRAHDMQRVSRIRGLGCVLRTIDASAQAWPHHESQIYQAEIFKAAERLYRAELQRAIGSGALMVLEQRQRLKEDEMNAPAAKLTSHKSELLSQLPNLWTFLLELSECNPPTSFTALLHYYLSYQKDVASDHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI21</accession>
    <name>S0DI21_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423767.1">
        <property type="nucleotide sequence ID" value="XM_023574295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI21"/>
    <dbReference type="GeneID" id="35395319"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01836"/>
    <dbReference type="HOGENOM" id="CLU_3068830_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="53" mass="5989" checksum="4E635EC2B08B015A" modified="2013-09-18" version="1">MKRSFMYRSDDLYAACRTEDPTIHVHDGEAIMKADVDEEDALNVADDGEAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIV2</accession>
    <name>S0DIV2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_01266</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="9"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424286.1">
        <property type="nucleotide sequence ID" value="XM_023580639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIV2"/>
    <dbReference type="STRING" id="1279085.S0DIV2"/>
    <dbReference type="GeneID" id="35394751"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01266"/>
    <dbReference type="HOGENOM" id="CLU_030651_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000043">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="184"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT62205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="341" mass="36684" checksum="9C70495CC062CB92" modified="2013-09-18" version="1">MSSATKEVLSKVRRMIPPMLEKFHKGQLGRVAVIGGSENYTGAPYFSAMASARLGSDLSHVICTPAAATVIKSYSPNLMVHPLMRQSENAKKEHEPAAWNASKDPESNADHIAAQIKDLLPRLHVLVIGPGLGRDPLMHATVARVIRAAREQELPIVLDADALAIVHTQPELVSGYDGAVLTPNVVEFGKLCDALKVKVDDDAPETARVEALAKTLKGVTVVQKGAKDYISNGETTLTVDLEGGKKRSGGQGDTLTGSIATFLGWRRAYLDRLWDVGKDPIGEHELVGLAAFGGSAITRECSRLAFSKKGRSLQASDLTDEVHISFLNIFGEDDEVDESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIZ0</accession>
    <name>S0DIZ0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific expression protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT62181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023580351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIZ0"/>
    <dbReference type="GeneID" id="35394777"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01292"/>
    <dbReference type="HOGENOM" id="CLU_180967_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7527" checksum="80E26A9D99D390D8" modified="2013-09-18" version="1">MDSGAPQTAPTGNVSSRRRSSGFMPAFASLSEQKRAGDANAARRASMSDQQAKGGMFSQFFHNNFGKNAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ86</accession>
    <name>S0DJ86_GIBF5</name>
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        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424431.1">
        <property type="nucleotide sequence ID" value="XM_023582394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJ86"/>
    <dbReference type="STRING" id="1279085.S0DJ86"/>
    <dbReference type="GeneID" id="35394594"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01109"/>
    <dbReference type="HOGENOM" id="CLU_030994_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="461"/>
        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="461" mass="49525" checksum="F844402F16B10519" modified="2013-09-18" version="1">MAIAITSQDCSKLYSSGAGNSWESTSSELPMIGVMSYHYPPLSPADHEMGMPPQGFMPSYTLPSQQLSSMTMVDPHAPSLGQDHSLDMNGSYSAPSNASLLASEAEEQQQNGNLGEKKRNKLGYHRTSVACGHCRRRKIRCITSPNDTQGRCINCIRLKKDCSFFPVDQASIDDSRSKQTSKSSTAPKGSSGTSSPVTPISNPVEQPKKTKPPFVPSSKRPGPIAVPKITEAEGVKGFPPQTKASGTSPTSMTPPEAGNQHPASWIITAPEQSPTSSSNLSTPWHTYATGSPMSAQFSPFTSVNHSPSGWPPVNSEPVPQGDVDMAWGQFAPPTRSMSYGGEPLSSNHPSQYSLMAPGRQFERRPSALSDAYATSMSGMVPGFDSSGMNTAVPFPPNAVSATNYPAWSQTQAYPGYTYVKNPETYGDDWSHERKGQDQQLQGNSGQQVISNAAMNTYQTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL91</accession>
    <name>S0DL91_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424188.1">
        <property type="nucleotide sequence ID" value="XM_023579451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL91"/>
    <dbReference type="STRING" id="1279085.S0DL91"/>
    <dbReference type="GeneID" id="35394858"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01373"/>
    <dbReference type="HOGENOM" id="CLU_038283_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="262" mass="29803" checksum="08255BC86DE36FB2" modified="2013-09-18" version="1">MKDSHLQALIIVLATVVPVTAITAVGCFLYRRNRQRRFLFLNRGITPIGDEEIESWKKDRNQEKARIIEAANNDLERQLQHQRQKSTSFSSIRKPLSVIVYDRPHPRVSEELSPRSLHHKHSIDTPSTPVVARAPNSRPGLTDEAVQGEDAFIPPVKRQPSRLAKLPPSARHSRTRSSRSSTMSAVSPRDPWHGHYPDAFFGTRSSSEYLPRANRSLDIRRQHQRMHSMSNMNRLSFDDEAFLGGLSPRPLIRKSEIGRAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLE1</accession>
    <name>S0DLE1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425316.1">
        <property type="nucleotide sequence ID" value="XM_023573626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLE1"/>
    <dbReference type="STRING" id="1279085.S0DLE1"/>
    <dbReference type="GeneID" id="35393624"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00139"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="360" mass="38809" checksum="5FF8B71B5F1767CB" modified="2013-09-18" version="1">MATDMLSITAPNYTSPSGYEISTVPRPIIIADNEVLIKVHAASINPVDVKKAAGVFKMAIKEEFPYKIGYDAAGVIVEVGKRVTALEVGDEVYTRLPEIGRGAWSEYVKCTDAYVSLMPESLSFADAASLPLAGVTALQVLGQYRGSLEGKTVLIPGGLSGTGALACQLAKNVFHAGKVITTVSTAKIPKVPKLLGEGTVDQIIDYTKEKISEAIPPKSVDFCFDTTGQAMEFLSLMVPSTGMIVSISTTPSASTLQASSVMRRPENPRIPFAGRVFLDAADAIRRLRAWRWGVTYMYHFLDPNREELDTLTGYVDSGMVKPVVGAKVDMRDIKAVREACDQTYKGKGGLGKTVFEVIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM24</accession>
    <name>S0DM24_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to inositol phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423659.1">
        <property type="nucleotide sequence ID" value="XM_023573151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM24"/>
    <dbReference type="STRING" id="1279085.S0DM24"/>
    <dbReference type="GeneID" id="35395420"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01937"/>
    <dbReference type="HOGENOM" id="CLU_033446_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT61578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="351" mass="38403" checksum="F8D57B7A9D4FD3BD" modified="2013-09-18" version="1">MNSPYAKELTVAIGALQKAAKLSQSIVCDKDKGAIEKDDLSPVTVADFAVQALLTATIKNAFPEDKVVGEEDASDLRQNPVLMERVWQLLEGLAGDEDTVSLCKLPESREQMCDLIDECGASSPSATGRTWVFDPIDGTKTYLLGQLYAINMALLVDGEQTVGIVGAPNLSIDAKAPLKNEYIDRTGEGCIFFAVKGHGAYIRPLRTDRPRRLPLYNSNDISLVTSSTVDSALSGIHEIVASRLNTAYPGNDLLPWVLRWAVLAMGLGNTTVWVYKRRDRYAKAWDHAGAMLLFEETGGKITDVHGKKIDLTAGRKMSANFGFVGAREDHGRVMEIVREVLIDQGKEEFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMA4</accession>
    <name>S0DMA4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424588.1">
        <property type="nucleotide sequence ID" value="XM_023569496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMA4"/>
    <dbReference type="STRING" id="1279085.S0DMA4"/>
    <dbReference type="GeneID" id="35394423"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00938"/>
    <dbReference type="HOGENOM" id="CLU_037460_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="300" mass="33628" checksum="51E9CB55284E7128" modified="2013-09-18" version="1">MSKFGAMIMGPAGAGKSTFCAALITHLNLNRRSAFYINLDPAAESFEHEPDLDIKELISLKDAMEEVGLGPNGGLIYCFEFLMENLDWLTEALDSLTEEYLIIFDMPGQIELYTHVPILPALVKFLSQPGSLDIRMAAVYLLEATFVVDRAKFFSGTLSAMSAMLMLEVPHINILSKMDLVKGQVKKKDLKRFLTPDVGLLDDDPIERARRVTEGPEAEDDESKAPDEKEQVMKGASFRRLNRAVAGLIESFSMINYLRLDVTNEDSVGAILSYIDDCIQFHEAQDPKEPHDEEYEDHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMF4</accession>
    <name>S0DMF4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425706.1">
        <property type="nucleotide sequence ID" value="XM_023571394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMF4"/>
    <dbReference type="STRING" id="1279085.S0DMF4"/>
    <dbReference type="GeneID" id="35398706"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05225"/>
    <dbReference type="HOGENOM" id="CLU_020336_16_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="297" mass="33095" checksum="816025DAEA04DB29" modified="2013-09-18" version="1">MSLNTVKTRTLEVGYYDHGPSSGWPVFLYHGFPYDIHAYDEVVPKLVSAGARVVVPYVRGYGPTRFLSDSTMRSGQQAALGSDVVELMDALNIEKAVLGGFDWGGMSVCVAAALWPERVVGLVSYAGYDIADLSSYQKPFAPSLECVCWYQHLFQQERGVACLTESRRDLCRILWKQWSPSFIFSEDFYNRTADAFDNPDFVDVVIHAYRFCFGNAKGDPALQKLEDALASQPKISVPTITLDGRQDPLKPGGTAAHAEHFSGRYERREVDVGHAFPMEAPDEFTDAILTIKKWETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPG7</accession>
    <name>S0DPG7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424539.1">
        <property type="nucleotide sequence ID" value="XM_023568908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPG7"/>
    <dbReference type="GeneID" id="35394476"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00991"/>
    <dbReference type="HOGENOM" id="CLU_2236802_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="105" mass="11399" checksum="B8FA0FD7C725E6CE" modified="2013-09-18" version="1">MAGGLRSSPTPQQEMADQAANTSAKRNAEETQTLRSKLVDQHISMRKLFGSKDRSFSGVVIDEFSSKLSRSLEASSTASGLPPRHYSRDGGEVASDVETEQCMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPK7</accession>
    <name>S0DPK7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable SCO1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_04408</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426456.1">
        <property type="nucleotide sequence ID" value="XM_023572311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPK7"/>
    <dbReference type="STRING" id="1279085.S0DPK7"/>
    <dbReference type="GeneID" id="35397889"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04408"/>
    <dbReference type="HOGENOM" id="CLU_050131_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="150"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT64375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="281" mass="31910" checksum="88C6E1E4BAB7F69F" modified="2013-09-18" version="1">MSNSVTTSRALRGVFSSLSTRQCQRCLSSSALQPKQLRPTLPRAPIQSRQPITQRRTKYKTIEQAKSRYSNGPFSWKAGILFVGTCGLLVWYFEFEKARMQRKRIAEAAKGVGRPKVGGTFELIDQDGKPFTSEMMKGKHSLVYFGFTRCPDICPEELDKMATMLDIVEEKAPGALLPIFITCDPARDTPKALKDYLGEFHEKFIGLTGTYDQIKALCKKYRVYFSTPQNVKPGQDYLVDHSIYFYLMDPDGDFVEALGRQHSPQQAAALILDHMKDWDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPS1</accession>
    <name>S0DPS1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable MNR2-Manganese resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424639.1">
        <property type="nucleotide sequence ID" value="XM_023570119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPS1"/>
    <dbReference type="STRING" id="1279085.S0DPS1"/>
    <dbReference type="GeneID" id="35394367"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00882"/>
    <dbReference type="HOGENOM" id="CLU_007127_10_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="834" mass="94040" checksum="481FFBC517E94669" modified="2013-09-18" version="1">MSSNRFADLASTSKATPPISTSNQLQAPESSNNSNASKARKRKGHRGGRKKRTRRKSFAALDDDDDHDEDREATGEGFFNLPRANLSNTSIDSEALLDHRDHQPLRPRRASTTPAASGIPVSPYSGSASNRLRSIPAVSAEEEHPDHTPWDENAPLLGESVTSGYGASDARSNQTRSRRASNKSSTTRLGTSSGARDNYDVNAPPSMPGSPTFGTADRIELSLGDVMIRDGLGASRDDSPHRMMGDIDILSDMEGMGDNRPDMGRRMATGAEQDVCFPAPGMSELGDDDTQSQAHEHRQYRTRRRRGQWPDLSVLEEWSHMEKEDRTEERRVKRITEPQLINGRLRPVRKGWYQTDEESPYRFTYFNEEFQSTIHSQTISELVQPGGGFRELFVPDPRVLSDDESDEDDMELTPLPTGLRHHSTATEGNSKVHTRQPSLSTVHDHHDLREGTTSPLRDPLAHVASRSESGRATPTGRKSADESVHVSQNTAGEPKERTVRYGERPVWWLDVLCPTEPEMKVISKAFGIHPLTAEDIMLQEAREKVELFRHYYFVNYRSFDQDNNSDNFLEPVDMYVVVFREGVLSFHFSKTPHPANVRRRIRQLKDYLILSSDWISYAIIDDITDVFAPLIQNIEDEVDEIDDAILKLHSSADKRLNETSSKNDDALTNSDPGTDMLRRVGDCRKRVMSLYRLLGNKADVIKGFAKRCNERWEVAPRSEIGLYLGDIQDHIVTMTANLGHYEKILARSHGNYLAQINIRMNERQEQTADVLGKLTVLGTIVLPMNIITGLWGMNVWVPGQEYEGDLTWFFWITAGLLFFGLACYMIAKRVYNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPW9</accession>
    <name>S0DPW9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426562.1">
        <property type="nucleotide sequence ID" value="XM_023572438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPW9"/>
    <dbReference type="STRING" id="1279085.S0DPW9"/>
    <dbReference type="GeneID" id="35397775"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04294"/>
    <dbReference type="HOGENOM" id="CLU_077999_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="157"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT64481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="232" mass="27470" checksum="FCD820E4A475682F" modified="2013-09-18" version="1">MTDSPPTEPRARSRSPAPKDKDDRKGRDDTHRENDERRQRRDRSRSRDRNNNRDRRDSPPRRPRDRSRSPVRRPRGSGGFKWKGERRDNDRNSDFRRRSPQRHRDRDYGRDRNYRRDDRDGGRDRQREGERDQRRERKEKKEEKPKAPVAQAGEEMIIVNVNDRLGTKAAVPCLESDTVGQLKMMVAARIGRDPGQIILKRQSERPFKDHITLGDYGISNGVQLDLEIDTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQI8</accession>
    <name>S0DQI8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426925.1">
        <property type="nucleotide sequence ID" value="XM_023572880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQI8"/>
    <dbReference type="GeneID" id="35397378"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03897"/>
    <dbReference type="HOGENOM" id="CLU_943490_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485170" evidence="1">
        <location>
            <begin position="18"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="296" mass="33312" checksum="601C29928BC37471" modified="2013-09-18" version="1">MLFLNTLVLSFVAVGYATPLAIRLDNTEPPENATFIQCHEGTTDPICLKIRGPSSDVITEIVHPDGTVEVHRNKYTREQLKDIRRQNKVKSVEHKPGHTVRDGSAAFINDLTKRESAPRICRSETQRWWDQNDWGYWYQAWHQVGSCFYCNQCTEAIAVGFSVSQTWTVGLSAKFGEVIEASFEFSWGETHTLTDTRTCQWNNVQSGCHSIWYQPLMSYHNGYANYQTHTHCPAGQGQGASDTYYDHNYAYANVNQIGNNNGVNQGNLGCDSGCQGSDHRQCQYGNNGGSLWPNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR19</accession>
    <name>S0DR19_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_03730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427080.1">
        <property type="nucleotide sequence ID" value="XM_023573065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR19"/>
    <dbReference type="STRING" id="1279085.S0DR19"/>
    <dbReference type="GeneID" id="35397211"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03730"/>
    <dbReference type="HOGENOM" id="CLU_027514_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT64999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="496" mass="56397" checksum="C9CC1DBDBC6F6620" modified="2013-09-18" version="1">MSQTEQIFPMPPTTVVRVGTPRLDKYQRLIARLYEAMVLLWIEQPIQGPQVTIKHDNISLTASRRRLTTGLAHYCDWDKGGRATTSIGIEDSEESSVFWVASNQGFEQGEFTLAHRTPTFLRQTLQRLQDVTREPDPSVGWLAEQVNNLARSFAAFAAPRIRKEASLLSRMATLCIDHLNGSVTRRGNVADTEARSLKLWLQRFQYREVLGAYDICMSAYISRNDPQMDTLLRLSQEALVDEGSEMLATASYNTRHFVGRLADHIRVSKHLVEDALRVRQVLDVFRVSEVPAPSGAQPPEIDSHTNLDSILGRMVSNGDEDFSYLQKDLSRFKNHVGLEDRVKEQFLKLQSNPPIVHCEVQVLEHFHRNGLRFTDDDHFIGTSKFSCFCCKLYYRHHPSRPVEPDAHEQIYLNWGPINLAQGSHDTLYRELRDTLNPVIRDVRDAFFRAIRKKNISVFNRPNSITGLTRSVDTLVFADSDSEADSEQEGGTALSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSW1</accession>
    <name>S0DSW1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425749.1">
        <property type="nucleotide sequence ID" value="XM_023571445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSW1"/>
    <dbReference type="STRING" id="1279085.S0DSW1"/>
    <dbReference type="GeneID" id="35398661"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05180"/>
    <dbReference type="HOGENOM" id="CLU_475693_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="573" mass="65804" checksum="B85C39F344DE4A53" modified="2013-09-18" version="1">MDGQRRLGHPSSGLSITVSNLRNLVQRLTADLRENIGFTDYFIPLLESLASQAANAEAPTNKITHLFYSAEGLNAHSPFFRMEASLECNILENLVHLDLCLCSEDGDSQAFEGFTVCLANARSLGSLKICMDKDPFMSTFGVIPTLPKLVIVEFVEVKSIGNPKGAWISQTVAFIRRHAKTLKRLYFTSATVGRSFLTDLSRLDSLYLDTFVISSGDDTDNDGDDYGEDCDDDYYSDSDSVLSGVKRHERMNEQIVLAYVNRAEDPDRKIPLPSYIGQKTQISTHSLVFDTTTCQLSAFHATRDNLWQKRGYDLKDIKALDSATLERRDEHGIAHSLGPRRIYHIETGLWVDSDEVFYDPVTDEEVDEPFSNREMPKDDSWTVQGQHTWDSEMGLWRDGRGKLKKFAAEMELPERPNVPVEDQDSDFHIDMQPFYDREEDEYLLRIENSPRWDWGRDANGQVWYWEVNGTAGHATETWLFEHNGEFVYGHEPLDFWDDWYDEPGDKAESTPYGWNLYTFLASNRLGSEIPQRSTCKPLRLYCKKDDPMYGNNDLFRHLPKPMDYEVWSDEQWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTK3</accession>
    <name>S0DTK3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426798.1">
        <property type="nucleotide sequence ID" value="XM_023572726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTK3"/>
    <dbReference type="STRING" id="1279085.S0DTK3"/>
    <dbReference type="GeneID" id="35397516"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04035"/>
    <dbReference type="HOGENOM" id="CLU_018202_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF34">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="156"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="462" mass="51902" checksum="9FBCD71D53607CC7" modified="2013-09-18" version="1">MLFRTAIQHQRRLLPGPSQLHIQPQLRTVTNAALRTSLKPTQAPRVEEPSPLSKIPMGVLLRSVALTTVMANRWLLRPSLAFIALITQSNSAILNPDKNPVLSRVLQWTIYDHFCAGNSIPEVSNTVKYIKNLGFHGIILGYSKDVVLDPNVKLPKIGIEDYPKECYDMIDEWKKGNIDTLNMIEAGDLLAVKVTGAGPIAVDALQAGKPMNSYLHKALNDICSETQRRGCQLWIDAEQQAMQPTLDEWTITLMREHNRDGNALVYNTIQAYLKGARQNAKRHIQLAAQEGWTVGIKLVRGAYIENEIRSLIHDTKDDTDSSYNDIADMLISRRVPDGPSNLKFPDAALVLATHNAESAQKALSTHRKRLEAGLPTVPMKCAQIMGMADELSCKLLQDYEQAVKKNRVTAETPKIYKCLPWGSVQECINYLYRRAVENRGAVERTQHMALTMRQELRRRILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTS7</accession>
    <name>S0DTS7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426878.1">
        <property type="nucleotide sequence ID" value="XM_023572822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTS7"/>
    <dbReference type="STRING" id="1279085.S0DTS7"/>
    <dbReference type="GeneID" id="35397430"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03949"/>
    <dbReference type="HOGENOM" id="CLU_526795_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="75"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="517" mass="58944" checksum="EA7BFA0AC458990D" modified="2013-09-18" version="1">MGTSHQASIFPMPSRNCSILPNIGPFTARQVYDNLPLAQGSQYIRVLDVHKSDPADSDRLTGTLRTVDLRALPKFTALSYVWGQGSYHKIACNGCDINITQSCYEALTSLRESCQSLTVWVDAICINQEDTGEKEQQIMLMGRIYTLAEIVYVWLGVGNTKTDQAAEYIGAISQFRLFPAKVWPSSRSHTRRNLSRRLIEIGRYILPLAFRNLCIEPLITERYQKYTLLWIIHAMPYARLIYAERIDQLSSLPFVSQDVIHALLDQAWLSRAWTSQEMTLASNPVLICGKQHIPWLVMHQALTFIEHSATQALIDPVNSVISEIQRRVHDDVSHSDSFKKWQALFDVWQTIPRHSRRSSYRHSSVQDSSCSVHDCVQALVTDKVFRSKPFVRLTLGIYHGAVVFRLIFITSFIGGLQLLFLALLPIPFSYFTDNLTKCSFDCIQGSKTRMYSLICRISIQPQNYLVALAQAIRDRNSRWPHDRVYAIDNVLRQLGAKPLPLIIRNHLARFIAMPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTX1</accession>
    <name>S0DTX1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to poly(RC)-binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_02879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427976.1">
        <property type="nucleotide sequence ID" value="XM_023574662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTX1"/>
    <dbReference type="STRING" id="1279085.S0DTX1"/>
    <dbReference type="GeneID" id="35396361"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02879"/>
    <dbReference type="HOGENOM" id="CLU_022670_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070935">
        <property type="term" value="P:3'-UTR-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903138">
        <property type="term" value="P:negative regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903753">
        <property type="term" value="P:negative regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="131"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="288"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT65895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="372" mass="39593" checksum="D5EB08A65351ECDD" modified="2013-09-18" version="1">MSAPQDSIPGNGSDILDQMDQLRMDDRLGPDGEPAPKTDEEYAQAQLTLRAIVSSKEAGVIIGKGGKNVADLRDETGVKAGVSKVVQGVHDRVLTITGGCDAISRAYAIVARALLEGAPAMGMGGVVQSNGTHPIKLLISHNQMGTIIGRQGLKIKHIQDASGVRMVAQKEMLPQSTERIVEVQGTPEGIQRAIWEICKCLVDDWQRGTGTVLYNPVVRTQPSGSGNASGGAGFSQGSGRSDYGGSPRVMRTGNGADFSNGSSRPYNRRSDSDAALRGPPTHDENGEEIQTQNISIPADMVGCIIGRAGSKISEIRKTSGARISIAKAPHDETGERMFTIMGTAKANESALFLLYENLEAEKMRRSQLQEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTX8</accession>
    <name>S0DTX8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427987.1">
        <property type="nucleotide sequence ID" value="XM_023574675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTX8"/>
    <dbReference type="GeneID" id="35396372"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02890"/>
    <dbReference type="HOGENOM" id="CLU_056204_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF5">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="356" mass="40324" checksum="A819280BB026CA6C" modified="2013-09-18" version="1">MGQERSGASQCSTNPSLSTQKGPSAIKKKVTRRDPEKRRLQNRLAQQAYREKQRKRIQELERRAAEQGAALQESNDRSLVHVENPVAGLTSAPVSEILVDAETIDPSTLHPHTGNSLSQATTDVGTWGASLIFEDFDQWISENPIYDEYTTPVLFFNCGCPTLHIPNHSREILLPVIPDPYKNNLQIDIICIISAMLENCLSLGITRSMYCSDDAISPFYRAQVDSDPNPEAIITSVQRGSRTLHFDLRPTRKQVVANHHPFIDVIPFKDIRDNIIEKMNDMDEDEFFHDSLNHLTCWGGVAGAHTGTPWDSRSWEATEEFILKWSDIVGGDEGELARNSRWWRSHRGERIVTEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTY6</accession>
    <name>S0DTY6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_02895</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427992.1">
        <property type="nucleotide sequence ID" value="XM_023574680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTY6"/>
    <dbReference type="STRING" id="1279085.S0DTY6"/>
    <dbReference type="GeneID" id="35396377"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02895"/>
    <dbReference type="HOGENOM" id="CLU_003041_18_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="198"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="457"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT65911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="609" mass="68098" checksum="956E21A12E87D46C" modified="2013-09-18" version="1">MQRIATRSVCSVCIRSSRPTTVARSSLQTCISQRLVSQHFKPRPSRMVLSDRVDRPPPSRDDRRQRRETPGPFGGMNKKYANIDSTRRVGPHRAMGGKDGNGGKTRERENRRGGPRDGDDRKALKMQRALATVSYGKRTVMKESMTDYETFDNFDLIPALQVAVNEELFKGMTDIKPTPVQRLAIPALLGQRSPDDLKRPTEEMRSFLLAAETGSGKTLAYLLPAIDALKTAEAEDPELKAYRERWELEKQRQLEGHSKGKPFDEPHPTMARPKVVILVPTAELAHQVTKVSKALSHVAKFKTELLSSDLKPQQIQRNLYGPRGVDVIVSTPHLLASIADSDPNILSRVSHLIVDEADSLFDRSFAPVTTSIVERALPSMKQFVCCSATIPRKLNNFLATNYPKMVRITTPNLHAIPRRVQLGVVDVSREPYRNRKDLACADAIYSIGRESASHEGPVKGEVDVRRIMVFVNEREKTEELANYLREKGINAEALHRDTPEKRHGEVLETFTSPAPLRIPTPSIASKARSLANVRVLVVTDLASRGIDTLAVRHVILYDVPHTTIDFIHRLGRAGRMGRRGRGIVLVGNDDRKDVVAEVKNSMFRGQALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU62</accession>
    <name>S0DU62_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable transcription factor Pig1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_02989</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428077.1">
        <property type="nucleotide sequence ID" value="XM_023574786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU62"/>
    <dbReference type="STRING" id="1279085.S0DU62"/>
    <dbReference type="GeneID" id="35396471"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02989"/>
    <dbReference type="HOGENOM" id="CLU_003487_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT65996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="896" mass="99710" checksum="72F1F73AE3436782" modified="2013-09-18" version="1">MAGPSPSSSNLSQNIDPSPGGASSLAKPEKGLALYACGHCGRRYSRPEHLQRHVQTHTLGRRFACSICGKTFARADLKKRHETNHENDDTKKRRRTTSLNTGRVTHACKACATARVKCQEEKPCQRCVRRGLTCVSSEASSSAAMNLVHLSTSARSKTPVDDEHDSSNASAEYAPTSFPNPTSYSADQPSLYGQNTHFHGHSRSATPNTGDLPPSSEAGSSSQAGTDQLPFCDFLRDVLYEHQYDQSARIPENQGLAVLNFCNDSNMELSDMDFGLLDHWNTDGMASSAPVQQETPKSPIDMDHMRQNLVTAWDVSPWRWDPVANDNAFGEQGNLPVSKRDVASIQAQASKEGFRRVVDQKLDFAARDGVLALVLGACQPDTMSSRISGSFPSADLLDTMLHVFLNSHTNQVSDYIHFPTFKLNEQEPEWIAGAAAAGAVLIPVPTLRKFGYALQESIRIVMPRRFEENNEEILNIGLIQAIVLGQDTGLWSGNRRKMEIAECHVNIPVTMMRYRGKFQRSSYPMLSVTPADEGANLEQKWRTWVEMEKWKRFVFHLFLRDSQQSMTALTNPVMSYAELTLPLPASKELWCAKTAKDWKDAYLRREAGHMKRAPSVGDLFRDLNLLSENRHRLDVQFSAAIYLQAFWLLVLEYRNLCSSCRTRSYIQDTYEGSSSLLAARRHQLLQDLQAFKTTTTNWPEVTAQERLLLNQLMMALHISMDDLQLFAGKEGDEQAHRTFPVLQQWVESVDSRAAIWHAGQVLRFAKLFPSAQLKNFYAVGVHHAALALWTYGVITKAGSQQDMSSQHDKVYIDGPEAMSVQQYIATGQGVPVIRGPNQRNGATEASVENPKTTMEAVHDILLANFGGANRMAPAIVENLSILIRQLGNVAWAVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU74</accession>
    <name>S0DU74_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_02999</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428087.1">
        <property type="nucleotide sequence ID" value="XM_023574797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU74"/>
    <dbReference type="STRING" id="1279085.S0DU74"/>
    <dbReference type="GeneID" id="35396481"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02999"/>
    <dbReference type="HOGENOM" id="CLU_009193_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000019">
        <property type="term" value="P:regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009303">
        <property type="term" value="P:rRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00660">
        <property type="entry name" value="Topoisomer_IB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="424"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="791"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT66006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="909" mass="103995" checksum="B85BB8412435487B" modified="2013-09-18" version="1">MSYSSDDDRPLARANGHRLSSSKISRAEDDALDQPVSKQAAKMAGLSVRNGPLEDAMDIDEPATNGASKRKSRTSISKVNYKDDESSDDAAPLAKRQKKQANRVPQSDSDDEPIARARGKKLPPSYDETALPESSGDDDEPLSVKLAQKKRDMEKEAEKQAKVIRAKERAKKPAAKNAVKDESDDDVPLAKSSASKRRSNGTAAKRKSNGVKKEESDSDAPISKKAKAKPTSSAKKAVKAESKKASESEDEDEYAWWNAPKKENDDIKWTTLEHNGVLFPPDYEPLPKHVKMLYDGQSVTLAPEVEEVATFWVAMMTPASSHHLENPVFRKNFFEDFKEYCDKYGVRDAQGKKVAVKSLEKCNFDKIYAYWSEKVEQNKSKNMTKEEREAAKAKKDALEAPFTHCLWDGRKQKVGNFRVEPPSLFRGRGEHPKTGKVKQRVQPEQITINIGKGAKVPEPPKGHKWKAVQHDQKATWLAMWQENINQNYKYVMLGADSDIKGQSDFKKFEKARELKKHIDRIRKDYTKELKSEIMADRQRATAMYLIDKMALRAGNEKDTENEADTVGCCSLKYEHITLEPPNKVTFDFLGKDSIPYRETAIVEPQVFKNLKLFKKAPKTTGDDLFDRLNTAQLNRHLTGYMKGLTAKVFRTYNASWTMSELLRKLASDPRSRGTVAEKVKLYNDCNREVAVLCNHKRTVGAGHEQQMAKLGDRIKGLRYQQWRTKMMILDIESSYKKKKGAAWFERDEELNDEWVKEHQQFLLEEQRTKITKKFEKDNEKRKADKEKPLPEKELKERLQAVKEMEAKFKKENKTKKVEAEGRGVTVDKLLKAVDKFDERIKTLELQAQDRDGNKEVALGTSKINYIDPRLTVVFSKKFDVPIEKFFSKTLRDKFRWAIKSVEDEDDWTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUE1</accession>
    <name>S0DUE1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_03034</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428121.1">
        <property type="nucleotide sequence ID" value="XM_023574835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUE1"/>
    <dbReference type="STRING" id="1279085.S0DUE1"/>
    <dbReference type="GeneID" id="35396516"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03034"/>
    <dbReference type="HOGENOM" id="CLU_041954_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="148"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT66040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="391" mass="42630" checksum="06D1195DBBF5BEB8" modified="2013-09-18" version="1">MPADYNSTAQALALSPDRGSSPSPSRPPWSTTSSSRRLSNPLMNRRRASTSYTGGGKTSFVRRIWGTVNLLGEQVLKVYLRLSPFQRILALVGVVAAGVLGILAIIYSHVFFKWLEPKAEQWRALPGGWTLAFLLVFVTSFPPIVGYSTASTIAGFVYGFPLGWPIVASGCTAGALCAFLASRTVLSSYVDRMVGRDHRFVALGQVLRQEGIWYLTAIRFCPLPFSLSNGFLATIPSITPLAFTISTALSSPKLLVHVFIGSRLALLAEKGDKMSAGSKAINYLSMILGAAVGLIVGLIIYRRTMARAEELARQEGLEPTDLSAEEGEAGYADSENTMIMDPEDAAVLMSDDDISLWGRDGTDSRYHDDDDDDDDDEEDEGNTNKRRDRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVY3</accession>
    <name>S0DVY3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_03208</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428810.1">
        <property type="nucleotide sequence ID" value="XM_023575030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVY3"/>
    <dbReference type="STRING" id="1279085.S0DVY3"/>
    <dbReference type="GeneID" id="35396690"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03208"/>
    <dbReference type="HOGENOM" id="CLU_036024_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="445"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="255"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT66729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="479" mass="54557" checksum="BA92DFFE38A730EA" modified="2013-09-18" version="1">MANIEEWLANANEAIHISLVSPSESGLQHLATFNPRHTYSIFGEEEQIFGYRDLKVSLRFRANDMRPHLKTSYSKKFNVDGGPEPTDVAALLREGNHLPKIAFATASDFEESSKLIGDNWVPPGTLHATFDSPDGEYEIWRGNLADPTIQQLNSRLQIFVPFFIEGGTYIGQDPEMDSTELDLSDADRWTFFALYQKRKVADKTSYVFVGYSTIYRFYYFQPPTPPASPRSDEWELPKGEVDLAELPSRTRLSQFVILPPFQGKGNGARLYKTIFEHYHKIPQTYEFTVEDPNEAFDDLRDICDLQFLRTMPDFNDLRLDTDVTLPKKGTLPKLVVGSDKLETIRLQAKIAPRQFGRVLEMHLMSQLPKSVRPTMDIDGDKPEATQADKHQGKIWSLIVKQRLYRHNKDVLSQIEPHERVDKLDDTLQGVGLEYARILAALERSVKHSQSQPVANGKRKLGAEETEQDPGSKKARVENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWF7</accession>
    <name>S0DWF7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_13057</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428970.1">
        <property type="nucleotide sequence ID" value="XM_023575698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWF7"/>
    <dbReference type="STRING" id="1279085.S0DWF7"/>
    <dbReference type="GeneID" id="35406513"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13057"/>
    <dbReference type="HOGENOM" id="CLU_056777_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT66889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="289" mass="31881" checksum="702FA8D7346CC3BC" modified="2013-09-18" version="1">MAAAPDNLSSPMADLRVSAPFTLSGSDTSSVDDDAPLPFPEALPRADFLAQDFQPAAYLSALPHRHQTLEDLRSDLRDRSAAISSELLELVNSNYTAFLSLGSELRGGDDKVEDVKVSLLGFRRAVEEVKTKVTERKEEANALNGELRGVRSTIEKGRKMIELSERLSSLEERLSLDSLPNNDDWDEESEEEDEDDNYGSSPTRLLASAQECSRITKLLESLDPNAPFVIKMEERLTRCRNTLLLDLGNALKEAKKAGVKGQDRVLKCLAIYRVLDAQSEAVKALRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWR6</accession>
    <name>S0DWR6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428986.1">
        <property type="nucleotide sequence ID" value="XM_023575715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWR6"/>
    <dbReference type="GeneID" id="35406529"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13073"/>
    <dbReference type="HOGENOM" id="CLU_028829_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="406" mass="45937" checksum="5ABEBFD7C9659982" modified="2013-09-18" version="1">MAFLEDPRLRQRWNQIAHDTETITENAAAGIWTFQHNYINPCFSSIAQSIEQCTTVCLGDPEERLRKRRERELSHSRAEYSFDFYDDWYEEEQSGLFGTWGNEDWDRLLAGTGTQRRHTGGETEQPRRKRGMSYGTRDRRRKPSMDDDPTVIPSTQPIGFLSKLPWKMGGTLRYKPSAADLQDHPRRHGEGENEPLLHSDEDDFDLPVTRKRSGTTGSGDTSDSYRSRGDLFPSDGEGEEDAIPLDDEVTYDMVRKDDRSGRSGRTSSKGKRPASGLAGSRTVSRTTLRSVSSKDDYRMEQRSMSFSLTPDVEGPTLHNLEQEELMLQKEQDGDVERKKQAAAQLAAEKAEDDVYQASPSKAAYHHVEEVEDKPATQDAAPNSSQPDGTKSPEKTDFVPARLPHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX22</accession>
    <name>S0DX22_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to BTB/POZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429122.1">
        <property type="nucleotide sequence ID" value="XM_023575878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX22"/>
    <dbReference type="STRING" id="1279085.S0DX22"/>
    <dbReference type="GeneID" id="35406674"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13220"/>
    <dbReference type="HOGENOM" id="CLU_017395_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="37"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="468" mass="52885" checksum="13E410627250B0BF" modified="2013-09-18" version="1">MTSIASSDAGNLTVEPLSERNVSRIPLILPHERVFPIQIGSELFKLSGASLSSDAPSYFSQYFVCQLESAKERNDESNAAIRTLYIDRDPAIFRDISLHLQGYHVQPRDGEHFVRLFSDAQFYSLPKLISQLYEESIFISIGHREFQIPREIFNDPGNSPNYFSLGFAAFFSRPDDLFPGLDREGLIRPPSILPPSVPKRSADTFAELLHFLRGYPIRIRDEAHRQDLLSDARYFHFKGLEQRLIPHSLSYNQATRRDEIVLRLENIQKSGVSVFISNTDPLTGFVQYARPYVDEKPAELVLEIGGETTKLHFSGSNARAEFFRDTKARVAKLFELVSSKLNFHQAIKTEHLTNNGQLTNLGNALLKEDLVRIVLEPESAIILDGKDYLEDFISAAASDSSANEYPRKRKRADGDSGDEEWVVTTGQWRLRIQNAPNGRGVECILVAAKLDAMRSQLSRNMSRSFLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX67</accession>
    <name>S0DX67_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to polyadenylate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_05205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427139.1">
        <property type="nucleotide sequence ID" value="XM_023571416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX67"/>
    <dbReference type="STRING" id="1279085.S0DX67"/>
    <dbReference type="GeneID" id="35398686"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05205"/>
    <dbReference type="HOGENOM" id="CLU_016304_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12611">
        <property type="entry name" value="RRM1_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12613">
        <property type="entry name" value="RRM2_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000065">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000227">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000159">
        <property type="entry name" value="tRNA selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="137"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="273"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="407" mass="43332" checksum="B867F902AF4282DF" modified="2013-09-18" version="1">MDFAGVPPNNAAPAGPMSFPNGTPPAPDMGSAPPPGSGPDSPKTTLWMGELEPWMDENFIKGVFMSAAHETVNVKVIRDKNSGNAGYCFVEFQSPESATNALGMNGKPVPNSQRSFKLNWASGGGLVDRRDDRGPEYSIFVGDLGPEVNEYVLVSLFQARFPSCKSAKIMTDAMSGQSRGYGFVRFSDENDQQRALVEMQGVYCGNRPMRISTATPKNRGNHGFGGQGHHNGGPMMGGMPQQQMWNGGGMQGFGYGGFNPATQMNQFTDPNNTTVFVGGLSGYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVHRHAAEMAINQMQGYPIGNSRVRLSWGRSQNNSGVGTPYRPAPPPPHYMGMPSHGGPGNYGPQHFGGPAPGPQGPPGPPGPPGPGGPPQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX74</accession>
    <name>S0DX74_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">FFUJ_03000</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428088.1">
        <property type="nucleotide sequence ID" value="XM_023574798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX74"/>
    <dbReference type="STRING" id="1279085.S0DX74"/>
    <dbReference type="GeneID" id="35396482"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03000"/>
    <dbReference type="HOGENOM" id="CLU_027506_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485014" description="chitinase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="15">
        <location>
            <begin position="28"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCT66007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="373" mass="39654" checksum="9D3F148CE70A4C48" modified="2013-09-18" version="1">MRWISGVSTAATVLLATTVSAQTWSKCNPLQNSNCPSDDALGMSIDIDFSKGEVNSFAASGSPKYDSEGVSFTVARANDAPQLASLFYIMFGRVEITMKAAPGAGIVSSLVLQSDVLDEIDIEWLGSDNDEIQSNYFGKGQTTSYNRGEFHDVTNTQGEWITYTIDWTKDRIVWMAGGTVVRTLNAGDAEDNQYPQTPMQVKFGAWAGGDPNTNSAGTVKWARGPTDYSKGPFTMKVKSVVVTDYSTGDEYKYKDTSGSWESIESVGGEINGNENGDAMTVTATAQGTVATADGNVPVGGIAEDGSPATATQTGWPWTGSRPSGGAIPEGWRLNAKGKIIPAENSAFVLQPLHSVIAVIPFLAGIMTLAGRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX86</accession>
    <name>S0DX86_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_03010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428098.1">
        <property type="nucleotide sequence ID" value="XM_023574809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX86"/>
    <dbReference type="STRING" id="1279085.S0DX86"/>
    <dbReference type="GeneID" id="35396492"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03010"/>
    <dbReference type="HOGENOM" id="CLU_003334_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056030">
        <property type="entry name" value="DUF7611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056031">
        <property type="entry name" value="DUF7612"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056032">
        <property type="entry name" value="DUF7613"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056033">
        <property type="entry name" value="DUF7614"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24586">
        <property type="entry name" value="DUF7611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24587">
        <property type="entry name" value="DUF7612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24588">
        <property type="entry name" value="DUF7613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24589">
        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7611" evidence="2">
        <location>
            <begin position="570"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="727"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7613" evidence="4">
        <location>
            <begin position="863"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="1018"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT66017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1160" mass="128465" checksum="47C037153452B136" modified="2013-09-18" version="1">MENDIPTIQVPDGRSSRRDRLMGKLFGAKDRKGEEARSAANVESFLHSSSDNLTITNPPPPPPPSSLPKLAKLDTTSISRYPQALGLNHAAQQNRPLVAGRPDTTKSPRRSPRPNKKGLTVRFDDTAPEIIGEGGDESEIPTQEISKRKVARPKQQPQVSQPPQPPAHRRAPMPPGRPPPPDSAASGSPVDDFRPKPLSRTQTGFSSIYTPDSDEEPEAGLDCNSKSDELASPVSAQQHSLSPGRPIGARFLGPAARQDENRRSYIEIHSAQQREAEGRAFAEAARVASATSASSHNWDDPHSATPLSSSPVESRRRGPPSPEAQASKPSLEYSPAASLHSNSSSYSPPAPPAAVPASAPSLSGSASGAQAPAPTAVSATSTPTSEVNQLSRQPSIAPQRAPPMMASRALSVRVADGTSAAAEQALETFTSRTSHLFELFRLHAESVKPLSTCSLIEFGRGALWWFLKGRMGLEVAIRERPNSPQGQMQNDRDRQQAYANLAKAFWLCELVIPEIAQAQGIEIDPEVDDVSTSLVSALKKLAMSMKRNGFLPPEDAFLPQSIDKSIWVDYPPLSQDMIALLSGNWASGLTAMTSPMSKLRLLDSLPVGDTTDNFNYGRVPADAYLMEQGHEDQKLYFPCLLSMVRPQKSTGLVFILASQNGHVQLVIQENKNVGPIWDDVRWRKETCTVDIRLRRGFMLTIQLVQQDFRTLWNMYDFGSKVNNSLYPRSDESMVFRSTLRSFQVMDADPNYRQFPKEPTPYCEISLFEKLYKENGPAATRTWHLGFRIAVVTGPKTRTLSGVQHVYSPAQPVQFGFFRGDGDAPSLAIKYENGKSKGRMVMVFSDDKARIKFHSILTGTALDHDEKIYSDVPLKNFSVAQSLREPLGMAPFSRMPWKAVRVVNDEYGGEMPPTVLADHLKVVIDYQNGNVADRINVAPGELRVRLEVSNAKVFRVLRQPQKDMTISVSEAQVPKELPRNMSDALQLLRHNQTIRTFEFNNLKDLHDFQYAMTGFEVIFDALAVTFAIQRRRMVVPIHKKWEAGYTRIQVIRQEDKQLQLLAFFEDFHHGHCMNFLLKGTDVYESVQRSSKCGIKFVDAKFPLPRLPADKDGDYDDMAFVCLDLPDLPGEHDDISILFENESDRDALAQCLPAPIKGSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX93</accession>
    <name>S0DX93_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427159.1">
        <property type="nucleotide sequence ID" value="XM_023571894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX93"/>
    <dbReference type="GeneID" id="35398260"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04779"/>
    <dbReference type="HOGENOM" id="CLU_028977_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT65078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="591" mass="64441" checksum="2B99408D0252F78F" modified="2013-09-18" version="1">MVIKGSVSDSASVPLGQRRGISDLAQIALDLAWVSESAEQDSFARYRAYPSPPMSGSPPLPSKQPQDAGDRGQAPVGYSASSQTDTYWGNSNQQLPTDHRGPANMQTTLPRLFQPGPSDAPPFSYRRTEETLPRPVSYIQPGGPSMPQSSGYIPPGIPGAPSSYTSSVRPSVVENQPMTSPKSQRKTKGHVASACVPCKRAHLRCDAQRPCSRCITNGKEESCVDVQHKKRGRPRLRDDRETRYDPSRFPHPQDTTARRPLSIYPSGVPMGPGERMNPRYLERGPNMDAPTFPPPLSAGPRGADPVAFLNMKMDFAKASPTFMEAVGHVELQGQNLGDVVIPAEREKVASIRSQLIEEQTRKEPNYLPPILSRLDHIIQGLGFGAEDIGRFQLDRNEYLTFRSADGQPRQYPVRLGLEKEGSIYVVVMVLSLPTRHAYPLPSSPATREASHAYGSQPPTPQSLYRTPVPPGPPFDMPRGRFSEVPLVSRPAAVPPTQLPAAINPGAAGGAGSTSYAASPSHAEYGGPPSYNVPRSELPPASVYRPQAAFQLPPIRAQPGPEQPRPRTREERPNRVDIGGLIDKPDDPERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX97</accession>
    <name>S0DX97_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to NCA2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_04668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427164.1">
        <property type="nucleotide sequence ID" value="XM_023572019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX97"/>
    <dbReference type="STRING" id="1279085.S0DX97"/>
    <dbReference type="GeneID" id="35398149"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04668"/>
    <dbReference type="HOGENOM" id="CLU_008227_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT65083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="669" mass="75396" checksum="A05ECBBFED7DFD8F" modified="2013-09-18" version="1">MTLVSDQVRRLDAYLDRLPVLSEVASEDGQSETEEHGFAVAAAFSSPRLDHLLRTIQSLSTTSSSQPLLPAWRIRDLLISSDIPASAHLSVTEAQLGDETKSPYENELEWLLVSKATIQLHGVVLNTLLDQIVPLNDDIWYWDDVLGSYSYSSLYAVQSSPLRVWAWSQEVYTATKLRVQAGSLHHAPGELVDSTTSSLSQQWTQFYGIVHDSIRERSIANIQRRVLSPVALSRSEARRKQAQLKKLREITASGLGVLMDEGLQFGLDDDKAELQDHHDLKGVVERSVALIDMVLKEVSTLDVNISDFEDKVFAGVEEDPELSVHIEDSNTADRPAILARRLLTIIDKSLPEHLTAMHALAKENGRPSTLIRYWLPAIVGLLSSTTVLRILVNRKADIIEWFVEFGETVRDFWFNWVIEPTSKIISTIRHDKTSEIAIMSRDSLKADRESLERMVVDFALDKPHFANETGSTLTESQVADIRHKVAEGDVTPVLRAFEKDLRSPFMGTIRGDLVRSLLIQVQKTKVDLEVAMTGIDSLLKSQELVFGFVGLTPGVLVSYSMFQYLRGVFGGRSGQRQTHKAGKAIRVLRNVDRILSEARPTETNLLSYKDHGLLLSEVHILRDLVDKLMPREIAREFLEDLDDLSNMKGIQLQTRALERIRWAYARWLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXK8</accession>
    <name>S0DXK8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429271.1">
        <property type="nucleotide sequence ID" value="XM_023576063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXK8"/>
    <dbReference type="STRING" id="1279085.S0DXK8"/>
    <dbReference type="GeneID" id="35406837"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13383"/>
    <dbReference type="HOGENOM" id="CLU_368446_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="374"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="708" mass="77616" checksum="DBC83C20BCDC2416" modified="2013-09-18" version="1">MPLQPSISLTRRCLVSLSSTSRRTFAQQTRQTRPPPPPPFQTVATCPEPTCGCAATPAMPEDLPLDREGPLKGAIAGYAEHVLVCTGNADWPSRIEDDNGGDCLAADLKELFGRGGTYSDPFHNVSVLNSSFPSSVSPRPEVQTTSVYLVPSFKYVPFLPRVSFDSVEALAKGFLLPKKLHPAHEGLSPIHRDRLTRKEGYQGLLPGVQDVRDVLVLICGHTGRDARCGIMAPVLQTEFEDKLEMEGFDVLDGPVQVNLGDKQRIQGETGRGKTTARVGLISHIGGHKFAGNVIIYLPPDLKMGNEPHPLAGCGIWYGRVDPKNVEGIVKETILKGNVVADMFRGGIDAEHKMLRIGGYYLITPPSRPNNLNEITFVPYGITTREAISPTSFVITAVPRTPNPSLPYLTPSDNRWSYPLWSVEFKQPEVQISRHYTPLPPLSTEDPTDGSLRFYIRTVGDGEMSNYLGRRQVGEDVFLRGPHVGFELAERLGEHSRLVFLAGGTGVVPGIQAAKAVLEASEDSSVDLLWAVRKREEVQKSAPPRQSSWKFWQEKKPTPLGTEVENPSPVTKRLQDLKMTYGDRLRIQVVVDEEGTRFQDKDIREAIAASPGTVASFNAGCRFHDQAMHVYASEFALSDGPGCVCKSSEGTTPGKNLFIVSGPDGFIEYYAGPKIWLGGQQTQGPISGVAGYLQKQNPLLARDWLVLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXQ5</accession>
    <name>S0DXQ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to lustrin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_13518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429397.1">
        <property type="nucleotide sequence ID" value="XM_023576212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXQ5"/>
    <dbReference type="GeneID" id="35406972"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13518"/>
    <dbReference type="HOGENOM" id="CLU_001932_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UDENN" evidence="5">
        <location>
            <begin position="227"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="870"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="686"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="729"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT67316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1135" mass="125725" checksum="6FDBC735D4428C45" modified="2013-09-18" version="1">MENSSTPLADYFWIAGVESVSYHDPNSQPAPVVVPVESTIVEDGESEDEDTNGDQPKIKARHSRQGSANRLSRISLTDRFSIHTLDETDGNTKSNRSSATIRALNPPNFGGILGEGSMLMGDFDFDKALVKFAAEREVFLEDLTFSAGAKVQARAPMVNPRAERIKAEESDSGRLSPLRSIKGSIRRKMSFRDMNSVRKQPSNRISTSRAASIRTTRRLSNYNSVIPPPEPLNTDPDMHPLKRRFEPVLLDRYPPQEATDEIARRGKFPDYVPMFAFPNDIQIVSSDDRPRSTWHGFTMTSDDNSKLYGITIIIWTALNAEVAEEVEKKCEQWRQSHMSEEERELAASLGVRLAGERTHLSQLLAKLPTIPSGSPARERLEDEISTVEEKITLMTDMLRPLRHGAASKIEGLTAGESGLWTPRAYGILGRDAANMSFWKEWLKAIVTPMTDGGVLRIPPSSPSVGRWQPLERYVVNLCTEAFNPLGSKTQVELGVRELRLYARKEADNEIPGSRSIDLYALFRCLSLENIVALFEYAMAESRIIFLSSHTSMLHLACHALANLLYPLKWSSIFIPVLPARLLSALEAPCPYIVGIERRYDRIELPEDDYVLVDLDKDTIDATSQPVRLPRQARRKLMSLLQVAAPHKLRYGVTTGPPPYAMESFPYDAFSTENAALFRSATPKSTLGKWVSQSSSGFGEPDPPNEVLPPLFNAFASAKVDNGKSDRPSTSKSGKTSPQSSVSPVSINFPPMPSTPVSRSDSGFALAATLREKRSGHFGEEKMRRSSSFGIDKHPPYHKPNLPFLNGHQANLSISAISVDSQNSVVGGGGGYGNGYAPSTYAQSTLAASTIMPSMQIQPVRNTETTVWVEGHCFNWIPKDNTSICNICNDHAEGDGIYKCTGCKIFSHGRCLGHASLVCPEAFHPDRIRAAFVRCLASLLYTYRKYLGRPSKQQKANGQLYAFDMDGFIKSLPHDQHDYATMMRETQCFNEFIHDREMQPANNASIRVFDEIIMAKKARGRSGLSTGLSRLSTIRASHGASTYGGYAPPRGSSNSKIPAWLGDTSDHIWRTASVPLPKGNFPGEYRTVVTRTPARLDRSLMREPRSIQGMPRVEGRGARGLIRKQVPSMLGTTPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYG2</accession>
    <name>S0DYG2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_02451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427584.1">
        <property type="nucleotide sequence ID" value="XM_023574182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYG2"/>
    <dbReference type="STRING" id="1279085.S0DYG2"/>
    <dbReference type="GeneID" id="35395933"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02451"/>
    <dbReference type="HOGENOM" id="CLU_079096_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT65503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="176" mass="20122" checksum="63D1F0F172C51455" modified="2013-09-18" version="1">MTTRKLPNIIITGTPGVGKTTHCEALAERTGLRHLSVNQVVKDKECHEGWSDEFHSFIVDEDKLLDAIEGDVKAGGCIIDWHACDLFPKSWIDLVVVLRVDSSTHYDRLITRNYPESKLQENIDSEIMEVLLQEAHEAFDEEIVIELTSNTSDEMDTNVDRIVAWLDQWKKDNNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYW1</accession>
    <name>S0DYW1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_02609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427729.1">
        <property type="nucleotide sequence ID" value="XM_023574360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYW1"/>
    <dbReference type="STRING" id="1279085.S0DYW1"/>
    <dbReference type="GeneID" id="35396091"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02609"/>
    <dbReference type="HOGENOM" id="CLU_122021_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT65648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="114" mass="12998" checksum="CDE8ADD2716A0D5F" modified="2013-09-18" version="1">MAVLGSFRKWLSLKQYQLEVTFSVYMFTPWEKFFFSSIVFLLFSLTFIAACLYLPHHISFLVGRAWYYINGEHIDVAEVVQEAVKDMSASALSGTTASVVDVTKETVETVVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZU4</accession>
    <name>S0DZU4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_02991</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428079.1">
        <property type="nucleotide sequence ID" value="XM_023574788.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DZU4"/>
    <dbReference type="GeneID" id="35396473"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02991"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="748"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="794"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="871"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="66"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="392"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="753"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1076"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="462"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT65998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1318" mass="144726" checksum="848C03620F380962" modified="2013-09-18" version="1">MTVDHHDKIEKSASSPSSEPQGPLTNDAKEDELQAKAKARPERTANFKDYLRIFSYATKWDFFAYAAGFFASIGAGITLPLMNVVFGQFVGNFTEYFMPGSTTSQSEFNKSIDKLALYMFALFLGRFVLNSINKFVFRMIGIRLSSAIRLHYLQRLFGQSIHVLDSMPPGYATGTITSTANVLQLGISEKLGTFVEYNSTIVAAIIVAFVKNWSLTLVTSSIILYLFLVLGTFLPMILKVNALITKAEGRAGAVASEALASVRMVAACGAESRISRRYGQFVEETRQHGKLLSPLVGAQLGLIFFGLYAGFALCFWFGAKSYSEGRLDNVGDVLVVLLSVMIVVLSLERTSTPLLAVGKATVAACEFFVVIDAPQPAKGTLKAPEVSSTQDIIFEDVTFAYPSRPHVKVLDGLDLRIEAGKINAIVGPSGGGKSTIVGLIQRWYTLQDQHVLAKVIEKEKKGGRKNKKDESDEDADAENMVDNEPEESGPPIEVHGRILTAGQLLDDIDLKWWRSQIGLVSQEPFLFNDTIYKNVAYGLIGSPWENETEERKRELVREACRESFADEFIDRLPDGLDTLVGDSGAKLSGGQRQRLAIARSIVRKPSILILDEATSAIDVRGERIVQAALDRAARDRTTITIAHRLSTIKKADRIIVLKKGKVAESGTHDSLMTIEGGVYSGLVHAQSLSLGEPTDAGDESVETEDKPVLANVTSVVASEVDTSTEASKDKARNFFASFGRLFYESKNVWPAFFLTLFAGACVGAGVPLQAWIFGKIIVSFNDIGTDSNLSGSNFWSLMFVVLASGIGISYFVVVFVATRMSSTIRVKYQKQYFDAVMFQKTSFFDHEDHSHGTITSRLGQDPKQLEELMGLNMASVFVALFNVVGAISIAFAFAWKLALVSCCVVLPIMIVSAYWRFKYELAFEKMNNDVFAESSKFASESIGAFRTVTSLTLEDSICLRYQNLLNEHVASAYRKARWVSILFGFSDSASMACQALNFWWGGRLLSRHEIGLVAFFVCFMAITNGSEAAGQALGFGPNSAMASAAANRILNMRESRPRDKVSTSQEIPDTDGGMSIELENIAFKYPTRSTPVFKGLSLKIEKGQFAGLVGASGSRKSSIISLLERFYDLDKGRILLNGKDATDINLYEYRKYFSLVAQEATLFQGTIRENILLGVDPLAITDEQLHQACRDASIHDFVVSLPEGYNTNIGSRGVSLSGGQKQRVAIARALIRDPKVLLLDEATSSLDSESEKLVQSAFERASEGRTMLVVAHRLATVQNADVIFVLGDGQLLEQGCHAELLKRRGVYWNMCQSQALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E020</accession>
    <name>S0E020_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Cutinase</fullName>
            <ecNumber evidence="3 13">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_06741</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 13"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT67990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430070.1">
        <property type="nucleotide sequence ID" value="XM_023576914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E020"/>
    <dbReference type="STRING" id="1279085.S0E020"/>
    <dbReference type="GeneID" id="35400218"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06741"/>
    <dbReference type="HOGENOM" id="CLU_040058_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005146095" description="Cutinase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="53"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="193"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT67990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="234" mass="24400" checksum="85F6868BA828624A" modified="2013-09-18" version="1">MKFTTILSLFAATAVALPTSNPLSEREVLAELEKRQSGSITRDDLSNGASSACPPVIFIYARGSTELGNLGTLGPRVASVLESNYGSNGVWIQGVGGAYRATLGDNALPRGTSSAAIREMIGLFNLANSKCPSAKIVAGGYSQGAALAAASIEDLSTSVRNKVVGTVLFGYTKNLQNLGRIPNYPRERTLVFCNFGDLVCTGSLIVAAPHLAYQSDASGPAPQFLIQRVAATSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E040</accession>
    <name>S0E040_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to heterokaryon incompatibility protein het-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430085.1">
        <property type="nucleotide sequence ID" value="XM_023576933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E040"/>
    <dbReference type="STRING" id="1279085.S0E040"/>
    <dbReference type="GeneID" id="35400234"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06757"/>
    <dbReference type="HOGENOM" id="CLU_004184_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="47"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="309" mass="35827" checksum="A63822FD37649B75" modified="2013-09-18" version="1">MAEKGLAIDYSSLAPTTEIRILTLERGRGDDPIVCTLRPATRDGAEYHALSYECEDESKNDHFITVDGCPVQIRMNLYDALKNIRKPTEDQRLRVDAICINQSDVQEKSQQVAMMGEIFTNAVGVISWLGPARDDSNLAIYMMFHNDTPDSSNKDSRELKTLLPLCRRRYWRRVWIIQELHLAKSYVVWCGHKSIPDHRFERALAGLNCQNDTYSDDFSQSPANQHLMARYFRYSEINNLYRRLSVCIRGEFQCTREQDIIYALLNISTDYKRVKETFKIDYSKTPRDVFLKLLCQGNLSTWRRGDEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0C3</accession>
    <name>S0E0C3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430145.1">
        <property type="nucleotide sequence ID" value="XM_023577009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0C3"/>
    <dbReference type="STRING" id="1279085.S0E0C3"/>
    <dbReference type="GeneID" id="35400301"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06824"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="46"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="329" mass="36388" checksum="DFF2B0DCEE4E3AB1" modified="2013-09-18" version="1">MKSILIVGVPLELKAVQSSVTFPAPDNTISQPSPAIAVSDAATGYDTKAFLAAASEFDCVLVNTDGFALGEQAEIYWGIRLFELSARAGVKHFVYSGLDSVGPKTNYDPDLYVGHYQGKARIQDWIHAQKDVKMQWTIIRSGPYMELLSAVMSPAIEEGGSLTFQLPLDKGSIPFIHLGDFGKYVDWALQNPEESNHLDFGIATVLATGDDIAKASEKVSGKTSRFANVPIDIWNSVAWKALPNGPDTKIGFQSVKDDSGLLMTYGENFKNWWNLYKASPSDNSGLIQRDFEFLDRIVPDRLKSVEEWMKKVQYTGDKQDLLNLEAHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1I4</accession>
    <name>S0E1I4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to haloacid dehalogenase, type II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430630.1">
        <property type="nucleotide sequence ID" value="XM_023577579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1I4"/>
    <dbReference type="STRING" id="1279085.S0E1I4"/>
    <dbReference type="GeneID" id="35400815"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07338"/>
    <dbReference type="HOGENOM" id="CLU_045011_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="267" mass="30427" checksum="664F81E0689A7BB2" modified="2013-09-18" version="1">MSPGAISPLSKVKALTFDVFGTVVNWRSSVTDELTLRAYRKTSSDLKQDIRARVQKLTEEDWGRFAQEWRNSYGKFTRGFDPEKHAWKTIDQHHHDSLVELLKAWDLADLYSAAEIESLSLVWHRLTPWDDSSDGIHELGKTYKTSTLSNGNVSLLRDLNDFGNLGFQVLLSGEKFGAYKPNPAVYTGAARELGLEPHEVSMVAAHLNDLEAARACGLRTIYVERPQEEAWDKEDERYQNAKEWVDIWITEDDQGFLALAQRLKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3E8</accession>
    <name>S0E3E8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_13429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429314.1">
        <property type="nucleotide sequence ID" value="XM_023576113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3E8"/>
    <dbReference type="STRING" id="1279085.S0E3E8"/>
    <dbReference type="GeneID" id="35406883"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13429"/>
    <dbReference type="HOGENOM" id="CLU_004457_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000032">
        <property type="entry name" value="GTPase activating protein (Gyp7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="450"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="750"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT67233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="825" mass="94062" checksum="1746A8DA316B5508" modified="2013-09-18" version="1">MSQQDSGAADAPPQQPSRRSASPSNSFYALSDDEEGEYNTIRNAETGRGVKLLFSKSKVYVHPTPSSKDNIPGYIALLQQRGHHEERPTSSASNESATIASSDLLLAWIPESALGDSASIYVKVDLCDGDSPPKQSYLVPPPPTVTSHVGSVGGYAFAIPVSAVYSLLVRPPSLGWWYGSVIINSRAGDSFPALFFHDNECQSTILQKKKIARDTFDPFGESGQMFWGGDEVVKWLRRYVKIERSGAEPNIYLIEPSKEDSEAFGHKLTSSPSQIGRQDSNVGTQRRAGGPPNRDAEMDPFVKLIKETGWNIMEKFSKVTTFTRRAAQDIVENPNLPPQVRRLLRNPEVQTLQDEFDSARIYLARWAMGIQEQSDRDRRQRIWSANDVMELEDTDVGEFELLEGASNLSLEERRKTVTMKEWNTFFDPQTGRLSITIDEVKERVFHGGLDPEDGVRKEAWLFLLGVYEWYSTADERKAQIASLRDQYYKLKLSWWERLEGDGGEGDAGEWWREQKGRIEKDVHRTDRNVPIFMGEDIPHPDPSSPFAEVGTNVHLEQMKEMLLTYNEYNKDLGYVQGMSDLLAPIYAVIQDDAVAFWGFQKFMERMERNFLRDQSGMRNQLLTLDQLVQFMDPALWNHLQKADSTNFFFFFRMILVWYKREFAWLDVLRLWEGLWTDYMSANFHLFIALAILERHRDVIMEHLQHFDEVLKYVNELSNTIDLEATLIRAETLFKRFQRLVDAVDKKQNFPAPRYNQKEPSKSSEQTESGPSKGGKTSGKDKAAEPAAPPPQPKTITPELRKLLSKEVEVLPRKTVAQKGDGMPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3Y5</accession>
    <name>S0E3Y5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_07394</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431485.1">
        <property type="nucleotide sequence ID" value="XM_023577641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3Y5"/>
    <dbReference type="STRING" id="1279085.S0E3Y5"/>
    <dbReference type="GeneID" id="35400871"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07394"/>
    <dbReference type="HOGENOM" id="CLU_085752_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT69405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="161" mass="16389" checksum="3B3BC597615CBAA0" modified="2013-09-18" version="1">MVSELCPVYSPFFGAMGCTCAIVFTCLGASYGTAKSGVGIAAMGVLRPDLIVKNIVPVIMAGIIGIYGLVVSVLISDGLKQDLPLFTSFIQFGAGLSVGLAGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALLMNSKANVDAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E479</accession>
    <name>S0E479_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431565.1">
        <property type="nucleotide sequence ID" value="XM_023578577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E479"/>
    <dbReference type="STRING" id="1279085.S0E479"/>
    <dbReference type="GeneID" id="35398852"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05373"/>
    <dbReference type="HOGENOM" id="CLU_023303_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="421" mass="46692" checksum="C8BF3DCD966606C7" modified="2013-09-18" version="1">MTSNNNPLSYNGRSEDRTREMEQISGSTLDSFLMKHPGLGVNLSPLRLSSPVVIPQRRPGNKERGFVEAYAPDLQAFGIDQETFIAFIQSINNAVQASKWLYAIQVAAMGTGFIPNHIALGVSAAVQIVAGVIAKTETRWKTNSFMDRANVNFFQPRGLYCLLMSYSPISTINKERVDPAQAMLKLESTSATSSKAKRNLRNPLAGVSHGEEDLPDSVATLIYPTIERTTPDTDKKRTVFAKLNDYFDQRAQARYASESNGDVLSSVPRKPFSNRYLDPNHPASNGGLLGLLSGGKLTPNIEKQKESMRSAMANQEQLIRDQQSSQMENLISVLQGMDLTAEEKQAYIQQYESAYELQLQQFQHQSELLENGQRRISRNILYLMIVNLPTPEEIEVARNGRSATDLVQSSNGVAIASVDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4E1</accession>
    <name>S0E4E1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431686.1">
        <property type="nucleotide sequence ID" value="XM_023578723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4E1"/>
    <dbReference type="GeneID" id="35398984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05505"/>
    <dbReference type="HOGENOM" id="CLU_1758954_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16809" checksum="571481DD9A30AF89" modified="2013-09-18" version="1">MDPITVFQVTGTVVTFVEFSYNLISETRSIYRSPDDYATSQDIATDFQRTLTCLQANGTSEVEHVKTSLVISLKAIWSKDKLGERERLRGTKEDQELNAKINQLSKAVDRNNAQLDVFFEELDATTSKDDALGPARRRRLFSNLWDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4K0</accession>
    <name>S0E4K0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429709.1">
        <property type="nucleotide sequence ID" value="XM_023576529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4K0"/>
    <dbReference type="GeneID" id="35407960"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14579"/>
    <dbReference type="HOGENOM" id="CLU_063912_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="370" mass="39708" checksum="34DE684742E80A33" modified="2013-09-18" version="1">MSSALTTTVNIISAAIYTMVRPTGSVIDANPTATTIGLGCPRIHGKIDCGQNYNNTFVVGPWASTVVPEGLPSTGTFRWHWEWDSEELSYECLMSSGIRKTCTGLQVSRGYARSHTEREWTSHSWTVTETEDMLDTVQLPIVLTSGLEQLGTDFQATPTEDASEVSASRRKAATETFPPVTPTLFIYDAEEYMIHTPTGSVISVNPTATTIELGCPVQSDCPFEYSNTFVVGPWASTVVPEGSASTGTFHFYLANSYWGTALSVECLMSSGMPQTYTSLVTAMQTRTWVDEDIYGGPVTETAANMYPDETLAAQFTYMSIVITAGQELLGEATATSTDTSSPEETNGAGSNAVCVAGVVAMALIASLIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E514</accession>
    <name>S0E514_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to ankyrins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_07613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430877.1">
        <property type="nucleotide sequence ID" value="XM_023577885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E514"/>
    <dbReference type="STRING" id="1279085.S0E514"/>
    <dbReference type="GeneID" id="35401090"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07613"/>
    <dbReference type="HOGENOM" id="CLU_078327_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="218" mass="23797" checksum="ADF5E993EA1FBC30" modified="2013-09-18" version="1">MSTPNPFLLAADNNPALLPLLRENPALASSQDEHGYSLVHAAASYDHLDLLRALVREFNVDVDLKDEDNETALFVVETQDAAQVLVEELGANINHRGSEGLTAREKIEAEAEFPAVAEYLAMVQAKKADDPASTAAAVMPEVIPPPPEGMKVTVGTMDETTDIPEEIDPDFRRRIEELAQRDDFNTPQGQAELRKLVEDAVLGEGGVGDERNVRSKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E518</accession>
    <name>S0E518_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to DUF803 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432053.1">
        <property type="nucleotide sequence ID" value="XM_023579168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E518"/>
    <dbReference type="STRING" id="1279085.S0E518"/>
    <dbReference type="GeneID" id="35399382"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05904"/>
    <dbReference type="HOGENOM" id="CLU_011406_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000012">
        <property type="entry name" value="DUF803 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="519" mass="56593" checksum="893054ACF1B7C86A" modified="2013-09-18" version="1">MGLLGGISSGGSIALGIIVGLISTSVQSLGLTLQRKSHILEDEKGPHDVRRPPYRRRRWQIGMGMFIVANLLGSSIQISTLPLPVLSTLQAAGLVFNSICASLILSEPFTRWSLSGTILVTTGAVLIAIFGAIPSPAHDLKELLELMARRPYIVWMILQALFVLTLALAVDLINSMSSLSHDARFRLARGITYGVISGDLSAHALLFAKSSVELVIKTVAGRNQFVHWQSWAIVLALVTLALCQLYYLHRGLKLVSTSVLYPLVFCVYNIIAILDGLIYFNQTSLISPLRACLIALGTVILLSGVLALSWRLSDEQHTPGVGQSSLAPGLGLVEDTEEEESLLGSDNAVADEDSIPHTYQTFPPAIDETPLVPSRKRIPRWAERAEIWDELEDRDEPSTPGNRRRSSTLPRHTESSPLLPTKRSTTSGPVAEESGPSTESTPRRLPRRRRKSTGFPGLKARRYKRSRSSTDSGALGNILSLSWFRSRNRQSSQASTSDGFPWGTTSQQDSAETRGDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6T4</accession>
    <name>S0E6T4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432479.1">
        <property type="nucleotide sequence ID" value="XM_023579687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6T4"/>
    <dbReference type="GeneID" id="35399846"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06369"/>
    <dbReference type="HOGENOM" id="CLU_1042218_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="31416" checksum="B8EEBC326FE376F9" modified="2013-09-18" version="1">MSDLMDNVDSNPEGQRRIFTLFRGEHTFSGLIEWTTAMPKTLEPCLAVVEERLPTDENRPEEARTLVFNHFFNDGPRIGLVYKCVKQPIDLREAITRIPKPSPEHRRALGRTIATQVRSLYVHFQINHPALRTESFIFFVNSDPNLTTPYILDWARLASPEMYQHPEHQAGKPLWSDHVWSLMMVLSEIADWKPLEKEILDHAELRSRKLERKRLVTNPSWKDAMTAEFFQFGFEFLEKDRSTLEEYSRWKVKRFYDRLCKLLEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E724</accession>
    <name>S0E724_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430403.1">
        <property type="nucleotide sequence ID" value="XM_023577314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E724"/>
    <dbReference type="STRING" id="1279085.S0E724"/>
    <dbReference type="GeneID" id="35400577"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07100"/>
    <dbReference type="HOGENOM" id="CLU_038623_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055449">
        <property type="entry name" value="Iec3-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24244">
        <property type="entry name" value="Iec3-like_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="INO80 complex subunit 3-like middle region" evidence="3">
        <location>
            <begin position="107"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT68323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="332" mass="36794" checksum="9AD8BE35C434F98E" modified="2013-09-18" version="1">MKTEGATRHRAGYKSWKKKYRKMRIVFDHKMHDGEELHKQEDKAAALVKRLAVENDRLLDLLLEINNSPQIPPEKQVDVSLKPPSQADALVHPLDEEHELHKDTPKKKLEDLVKSVPHSSYTSAKETLPQTVSDLKAVDGETYPADFLSADDIDNYIYEIDMALDPENMLPTLAPRAHPGNHHQSHPHLKNPTSVTNWLRKHAPKIFLQDGEAHGDADDAEGGHTGGRKMRGSRGERGGRASTRGKRVSAAARSAAAADRDVDASMDEDLELTSTPAVRGKRKRNAEDDTGYKPRGSSTRPTKKKRKSEAAEGTPSARKSKKDKEAPLASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7A5</accession>
    <name>S0E7A5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431707.1">
        <property type="nucleotide sequence ID" value="XM_023578748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7A5"/>
    <dbReference type="STRING" id="1279085.S0E7A5"/>
    <dbReference type="GeneID" id="35399007"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05528"/>
    <dbReference type="HOGENOM" id="CLU_021768_8_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="138" mass="16014" checksum="7A6A9AE5FFA202FA" modified="2013-09-18" version="1">MLMGVPSLTCVFLINPWGLFATIQEFHRELRRGLELRDGEGAFPGLRELIDFHNGPWEGPVFTHSDLSSLNIMADGDTVTGIVDWESAGWMPPYWEYTSAWHVNPRNTFWRDAVDGFLTPLPHELEMERIRRQYFGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7X8</accession>
    <name>S0E7X8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable clock-controlled protein 6 (CCG-6)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430618.1">
        <property type="nucleotide sequence ID" value="XM_023577566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7X8"/>
    <dbReference type="STRING" id="1279085.S0E7X8"/>
    <dbReference type="GeneID" id="35400803"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07326"/>
    <dbReference type="HOGENOM" id="CLU_092869_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012700625" evidence="2">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="154" mass="15085" checksum="A7073A058259C82C" modified="2013-09-18" version="1">MKFATALAFAAGVAAHAKNVTYTTEVVTAYTTYCPGPTEIVHGDKTYTITEATTLTITDCPCTVTKPVITTSAVVCHDCPAPPAHHGNNSTLVPVYPTGKPGHGGESGKPGSPAGPGATPTAGAPSEVPTAGAGKVAALSGAGLAAVVGLAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7Y0</accession>
    <name>S0E7Y0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431977.1">
        <property type="nucleotide sequence ID" value="XM_023579077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7Y0"/>
    <dbReference type="STRING" id="1279085.S0E7Y0"/>
    <dbReference type="GeneID" id="35399300"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05821"/>
    <dbReference type="HOGENOM" id="CLU_052684_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT69897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="272" mass="30276" checksum="3D186CDFA8E8DAFE" modified="2013-09-18" version="1">MASRMGPRSVKDATRFTSTIPHATSKAAQRTPRIPGETPEQRVRRLRQAHLAAQHASISKTDKFIDASRRVFDVAHRWTVGSIVVFTVVAAVVSGYSVWDMVRYNRARRAEWVEAQKLLEADELAMARLAYIRGEATEEQILLVEEANQAAEARGEKLPPLLEAPSHRTHFEEHIKPTFKENTEENVTKPSSGKGVLGVFSSVLGSGEKKEESTQGVQDYQTQSAESGTVKVRLEEAMAAERERQQNGGPLDRLGVEPAGGSTPNKSWWKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E844</accession>
    <name>S0E844_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432909.1">
        <property type="nucleotide sequence ID" value="XM_023580068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E844"/>
    <dbReference type="STRING" id="1279085.S0E844"/>
    <dbReference type="GeneID" id="35402626"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09152"/>
    <dbReference type="HOGENOM" id="CLU_021599_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="450" mass="49875" checksum="739B8EAF088E7C60" modified="2013-09-18" version="1">MSRVASPPPEMSLIAFQGDFCFAFMFSNFVWRSYGTPWLDQAAAGKLGSLSLDAAKALSEANFGRSNHQRDIELKGIMQYGKCLKTLAGALGSGPVQGGPHLLVPILVLLMHAASYADQTGAVFHLRGLARLLHLCGPEAFQEQPFLNAFEATRATLLVASLYGKQRLFLEEERWRMVPYERNKRFKTPQSQLLDILVVVPGILQDHEAAQSMDEDGPGLRTELLGRVERQLVALYRWRWQWQARSGNHVETDAGNTPQLNGRAAEALGSIGTSRQSGRLRLGKFALATELMLYNATMMWLIALHWKIDPVSASARIEACADDAMPNEPATHYLSFEPLRRPGGAVTVRDPAMEICRVFEWVTHHHCRCKEPSFLYLFPMGVAMSVLETEPETKAWATSLLNISPITANYAYGQNAAGFGFYVTPEALHPGKVVAKTQLFSAQDIEELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E848</accession>
    <name>S0E848_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433138.1">
        <property type="nucleotide sequence ID" value="XM_023580347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E848"/>
    <dbReference type="GeneID" id="35402376"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08901"/>
    <dbReference type="HOGENOM" id="CLU_1496281_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="168" mass="19055" checksum="AB6C29364B680CF3" modified="2013-09-18" version="1">MSQSIHPTDQAAKEAGAARLLDLAFHRWQTHFPVPMPEYPAHQFSESALQVGHFKEDIPSDPPSTDPNPNREKGAKAYLRVERDMSQAGFRWCDAEGKPVDKNYIQITEGLDIGLLKEDLADMYNIHERRLVAKWNEDVKVATLRRAIQRFEAAGPSEVAAVRNEDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8I6</accession>
    <name>S0E8I6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433024.1">
        <property type="nucleotide sequence ID" value="XM_023580206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8I6"/>
    <dbReference type="GeneID" id="35402502"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09028"/>
    <dbReference type="HOGENOM" id="CLU_507178_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="533" mass="59752" checksum="5358266B5E3A9CB9" modified="2013-09-18" version="1">MAPKKTNTDADPSKVSPLNLAARRQYMESFFRQLPITKDVIEQARTKAIELQSKHLAGRGLSDVNVVYFEYHVDVTVWRLIMNLLMITKSNPWPWKVSIDENNLSDGTSPIFREWCRSHRSSAEAQGSASGTSQSPAQPQPPQHQAPVASAAPQPSVASGTPQPPVQQTSSKTAAPAASVARIAGLGEELSKLTVKSSPKATPKEPVEEKASPEAVTVPQPPVDATLAAKREVAQTLFDGEMKRQGQKCLLPGIQQSRWATSDGQQPLPYITSFDPQVQIRGDYGARNHEDIEEPRLPSLALREKIWQSVCKGMPWLSGPLCGPFELALPAWLDFHDLVCQDFERIQAEKLLDEDIVIAWRVSGKRPVSLVIGPNPAEIHSHEDIRFWIQVRNNWWRVAWWLSSAYWGSSIRLVEHLREVRDLACEGQLIDVPASMTRLFEAWGDIMSDPLLARNKASWNRNNMEMWVPQIHAILAQPRNTVGSLLDEWVFRDMPNANIRAQGVRDAWSRVAPVDAISWHQNAMLKLRSMLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9G3</accession>
    <name>S0E9G3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to DUF1275 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431178.1">
        <property type="nucleotide sequence ID" value="XM_023578356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9G3"/>
    <dbReference type="GeneID" id="35401512"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08035"/>
    <dbReference type="HOGENOM" id="CLU_061825_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF7">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="279" mass="30387" checksum="DA2B7B1C07A36891" modified="2013-09-18" version="1">MPDSGSDSPEAGVKGETKSPVASRFTTEIDTRWGDILLLICFFVAGLVDSAAFNMYGCFVSMQTGNTIFVGLGVSHQPENLPGKAWSRCFLAIVCFAFGALFFSSFHRFFGPQKRWVLITSFLIQALLTGLVAILATTGAVYNHPHGRETVHENGWIIERVQDSFPATDYAAIIILAFQSAGQIVASRVLKYNAMPTIVLTSLYCDMMSDAKLFTAPINDNADRNRRATGAVLLFAGAVSGGFLSKSWVGFAGALWIAAFLKLCITFAWVLWKPKSSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9J2</accession>
    <name>S0E9J2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433419.1">
        <property type="nucleotide sequence ID" value="XM_023580682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9J2"/>
    <dbReference type="STRING" id="1279085.S0E9J2"/>
    <dbReference type="GeneID" id="35402074"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08598"/>
    <dbReference type="HOGENOM" id="CLU_010595_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="431" mass="48582" checksum="A60E1EC198038A86" modified="2013-09-18" version="1">MSSEDSYAVQSGRQSSDGTPSEHANSDGNNTAMTSIMGTDEEHHHDDSDLDEDVDEDDMISIYPASQYPRVSASHRVETPFSPDSHAVDSDMAASTRSLWAQDLDYREIHGRRYCREYYMPNDDIEQWRMSLQHQVFMHVLDGELTLVPLQNPEHILDIGTGTGEWAIKMAELQPQCEVVGTDIAAIAETKSVPMNVFFEIEDAEDWDRHPDMYDLIHFRLMEGAFRNWSFVYDNTFFSLKPGGWIEVQDFVSAEGFAQFLSQFPDNSAMHELLRDLLIASEKSGRPRGIHHLEPRLLMEAGFVDVRVTEYSIPITVAEASAGKIWLISCLDSFEAYCLRLLTEYMDWDPEKCKQACEAAARDLANAAKDPEKSKGLQIKMRIIIGRKPLDAPPTDLAEFLGRSYSPVTEQNGDSPDPTLRPDDQTTAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9L9</accession>
    <name>S0E9L9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433665.1">
        <property type="nucleotide sequence ID" value="XM_023580987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9L9"/>
    <dbReference type="STRING" id="1279085.S0E9L9"/>
    <dbReference type="GeneID" id="35401801"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08325"/>
    <dbReference type="HOGENOM" id="CLU_053544_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094:SF2">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="289" mass="31428" checksum="39F4F50BA0BFC67A" modified="2013-09-18" version="1">MAAPIRSSLSRSGRTSVASIRSLSNARPAKAQVQPATVREPKPSLPPSDATLLEDYLRRGALSRTYFDATGVRWVGSSDDGPKDPNKAKLGKTLRVLQERLPTLLLHPLPHDILAPNIALHLFPSTHPHLPTVSGRVAYNAALWTSPIAWNRVPILGNVCIEVLAERMTTEPLTFLPRRAGAIPEQLVVRWCEKRKGSDSSSDRGVIARSLPFGRGVDPDKAFTGLFVFDFDAEGRVLSHTIEQAQAGGDWEAGVGAKVVGLTDWLLGGCKNPGTPIPMFERVRRGRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9P3</accession>
    <name>S0E9P3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Related to nuclear envelope protein Cut11p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_08334</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433658.1">
        <property type="nucleotide sequence ID" value="XM_023580977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9P3"/>
    <dbReference type="STRING" id="1279085.S0E9P3"/>
    <dbReference type="GeneID" id="35401810"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08334"/>
    <dbReference type="HOGENOM" id="CLU_029386_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106166">
        <property type="term" value="F:spindle pole body-nuclear membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="15" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT71579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="620" mass="69802" checksum="9D39E1E7114E27B8" modified="2013-09-18" version="1">MAPTTVRKAPYKDFLQPALHRRFTSTATVLLLVSYLLAVVLDGWKSYFWSWFPIGPVGVRTLFIFTCGLAIVVLRIANYHVGLRTTGPGFQTLRNTITQLQTYETLFWYGFSSLLFSHVFLWAMPKAANLSWITYFSGDRARLNERPLFLLAYMVSCAITQTFNHYRKDTDRLVLASSKGKNEKQPDALKLLITAVPATFGASLSGAASALPVALILYYTILRSFIWGWALMFLRIFYNLPKTNMLPPSWPSDLWLLFRCIEAGTFVHLIWNIGNFAFSKFMVKEPLKNGKPLTSESKDPNGSLLNGLKSKKLSIKAFAMWELAIIAQGFETRRQAIYEDIDRKDGPMWSQVYAICMEVVKSIETRIDTYGKVPDAPPAAPAPEPKQRVSAPLRDDPIFNSRGASKTMLSEVEKRLGQAALSPGESPMSNLSPIAKKTWKEAKDRVLTKEQQELVAPDHIKSQLEHWTLQVMEVDTVAALFQQDFRTQFAAAVLGTPYAEPTLCINAINVLHHLSVHSLAEDQFGNVHRDVPSIIRTFTSVIKKLEAFRLQFPLHWTDVSGKRISPEVEEVVEALKTALQQVLGKFEPYSSDLRLTLTDIRLAKEASATSKKSEMAEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA01</accession>
    <name>S0EA01_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433788.1">
        <property type="nucleotide sequence ID" value="XM_023581135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA01"/>
    <dbReference type="GeneID" id="35401669"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08193"/>
    <dbReference type="HOGENOM" id="CLU_100655_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="221" mass="24060" checksum="715B72FBFD76FC85" modified="2013-09-18" version="1">MLILPTIANALAEFTYDKYIKFTSLTGPDEVPCFLCLTTIHRDARLLCVAKDSAKPICLCCQNSTKKCGSRAVAEQISDAFKQSSNDRDVALNIQTQVMAANNELLSLQLLQTPGVSFSLEEMQTRVAAARPLFARDDSKAVRLRKALRRLPNADKTPHGSHDGELEDLPQELKDTLIAQMNEARGSGCTAPDCPPISAGLGPVSRGPSQAPPRKRKRNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAE2</accession>
    <name>S0EAE2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_05509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432806.1">
        <property type="nucleotide sequence ID" value="XM_023578727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAE2"/>
    <dbReference type="STRING" id="1279085.S0EAE2"/>
    <dbReference type="GeneID" id="35398988"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05509"/>
    <dbReference type="HOGENOM" id="CLU_006937_8_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT70727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="567" mass="64744" checksum="8D7D595F7A360764" modified="2013-09-18" version="1">MGEQIPVHKKFNTELTDYSVEHHGDQGVYADNLEVDALVVGAGFAGIFMLKTLRDRGYKTVVYEAGNDTGGTWRWNCYPGAGVDSEVPEYEFSWPEVYDTWTWPCNYPTYADLRAYFDHVDKVLDIKKDIAFNTVVVGGKFDTESGRWHIRTADGRVAKAKYLVLGTGFAARRYIPDWPGMDKFKGIIHHSSFWPDEKVDVTNKRCAIIGTGASGVQITQAWGPEAGHLKVFQRTPNLAVPMRRKYPSAEEQNQAKKFYPELFRYREENFAGFHYDWYEKNTFDDTPEDREALYEQVWKDGGFRYWVAVYKDNLFNAEANKESYKFWAKKTRNRIGDPKKRDLLAPTVENMPHYFGIKRPCLEYDYYEQFNRENVDVVDIKNNAIKEFTETGITLEDGTHHEFDVIAVATGFDVVTGVMTQLGLQSIEGAELEKEWKTGATTYLGVTTPGYPNMFHIYGPHGPTLLSNGPTSVAVQGRWIVDAIDKIKLNDIKYINPSKKAGEEWKKHIVELNDRTLFPTTRSTYMGGSIPGKIYEPVCYSGGIPAYKIEIREALDTMKGFEVVKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAT1</accession>
    <name>S0EAT1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to ankyrin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_05449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431633.1">
        <property type="nucleotide sequence ID" value="XM_023578660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAT1"/>
    <dbReference type="STRING" id="1279085.S0EAT1"/>
    <dbReference type="GeneID" id="35398928"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05449"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="415"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT69553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1129" mass="126783" checksum="F556A1E399F43AD3" modified="2013-09-18" version="1">MSWRTGNVPDCLPGDAERRRTAGADNFNRQGDRERLSHQDYTVGWICALDIEMTAAKVMLDDIHEALPTSREDTNTYTLGNMGIHNIVIACLPLGRYGLTNAATVANNMMRTFTSIRFGLMVGVGGGVPGKVDVRLGDVVVSKEVVQYDFGKRTGDGEFRPFGNLNKPPHVLTTAVAKLQADHRTEPSRIPSILAAMLERYPGMVSSTRSSTLQDQLFDASYDHIEASGQAMSPKVDSCEHCDVSRLVQRPARSSNGPRIHYGIVASANQVIKHSLTRDQLAKELDAICFEMEAAGLMDSFPCLVIRGICDYADSHKNKQWQPYAAMTAAAYAKELLSVIPTDKHYKTYRPTSSVGVDPVLQERRKALLESLEFREIHSRRLGVEVAHEETCKWLLEEPVYQHWLDRSKLTQHHGFLWIKGNPGVGKSTIMKFAYSQAMKTMGNAIVISFFFNARGDDLEKSIGGMYRSLLWELLSKASGLQKVLDDADLVPLSRDDRPIWYSEILRSLLSLAIASLGRQRLLCFVDALDECDRRDVYGMIEHFQAIGEDSVSRGSEVYICFSSRNYPFMDIGNGQELILEHHPGHEHDLEAYIRSKLKVKKHRKADADELRNDIRVKANGVFLWVKLVVQMLNEDFGYANSLAIQRKTLEEIPPELSDLIRDILRRDNKRPENLLLSIEWILFSTRPLKWEELYFALISGLHPDTLSRWNRRNTTIQDMKQFILSSSKGLAEITKPNAQTVQFVHESVRDFLLKDDGLRHLRRDLHLETEDTHSSAHDRLKACCHTYIQVDISRYINLATPIPDLKKDAALHLRKTLLRYFPFMKYATHCVLHHGEEAGSKIPQDDFLKGFSIKAWVVLDNILRDVGAIRADPWNKRPCHTSNASLIYILAKDDFTNLMAAAFRLGFASNIHKERLENPLFAALANGHRGAVKTLLQQEMSASQAEEICARLGYGKYFSVSKGHTPLHWAIQQGDVPLATILLASKEIIPVVSSSDERTPLSLAAENGYESIVRLLLAIETVQLDPRDYMGRTPLALAAIEGYVDIVKLLLSTGNVNVNSKDYSGCTPLLGVLMRLAHAQKSSSKAEFSSKLTIAKVLLENGADIHAKDNYGRTPLLYAKDNKLTGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAY0</accession>
    <name>S0EAY0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to cytochrome P450 8B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_05513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431693.1">
        <property type="nucleotide sequence ID" value="XM_023578732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAY0"/>
    <dbReference type="STRING" id="1279085.S0EAY0"/>
    <dbReference type="GeneID" id="35398992"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05513"/>
    <dbReference type="HOGENOM" id="CLU_018012_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT69613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="555" mass="61829" checksum="584AEB36CF01BC9A" modified="2013-09-18" version="1">MESQSLLTSLVDYRSPNVTILSTTVLAVIVAFALLNRLLTPRIDPREPPVVKPSIPWVGHIIGIIRHQADYSRILHNENPHVKIATLPMLNGKVYAAFDPALLQTLLRNKTASFEPFVFDYAKKTFALKQETFAKVKVPGVYDEFTEAIHASFQVRHLHHMNVHFLGSIAAKLNRATIRADSINAGKETVANGKLHVENLYLWCRDVMSLATTRSLYGDTDPFNRDPSLIDDMWYGAPSGIYASLTSQAFRRISPLLPPLALPLNHDAKSLQSALHAPKHRLQWYSEDHDIHDPSVSALVRNRAGALRKNGLTGYEIGKFEVILPNVATLNAVPTFYWLLLYILDRPDLLARIRAEAEDAAVVEDNNGKRSATFNIADFEERLPLLVSCYRETLRLANQTLSMRRILQDTSVTTAEGTTYILKKDTDLQLPAGVAHYEDSVWGADVNVFNPERFLPASKGSAEDERKRKAAYIPFGGGRHLCPGRNLAFAEIIGFSSALLLGFEIEAVGMGFGDVKMLGPQLAGGTVRPERYGAGLGAEMAMRRGWEDVEWRFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB16</accession>
    <name>S0EB16_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434184.1">
        <property type="nucleotide sequence ID" value="XM_023581493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB16"/>
    <dbReference type="STRING" id="1279085.S0EB16"/>
    <dbReference type="GeneID" id="35407349"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13895"/>
    <dbReference type="HOGENOM" id="CLU_084522_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014500">
        <property type="entry name" value="UCP019307_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019307">
        <property type="entry name" value="UCP019307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="69"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="177" mass="19673" checksum="D1C3F54179980C5C" modified="2013-09-18" version="1">MSPTPLSSLRVSKHLIPSHNLLPNCSIHQKPLLHYHAAFKPPITASQIEAHLNSIDVVIPQWRYTMYSQTHFHSTTHEVLCISHGRARLCFGGEDNEGRVEPVVETGDVVIVPAGVGHRLLEDLDGGFEMVGSYPKGCDWDMCYGKKGEGEKVEAIENVEWFKKDPIYGDQGPATEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB37</accession>
    <name>S0EB37_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_08464</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433954.1">
        <property type="nucleotide sequence ID" value="XM_023580833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB37"/>
    <dbReference type="STRING" id="1279085.S0EB37"/>
    <dbReference type="GeneID" id="35401940"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08464"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000181">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="53"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT71875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="423" mass="46443" checksum="69C8BFF8273EC60F" modified="2013-09-18" version="1">MLSTLRVASRQAARPAQFNLVAIRAASHWANVPQGPPAILGITEAFKADKNSKKINLGVGAYRDDAGKPYVLPSVREAELKVVDAKLNKEYAGITGVPEFPPAAAKLAYGPKNPALDRITITQTISGTGALRVGAAFLQKFFPGEKKIYIPTPSWANHKAVFNHAGLEVEQYRYYDKKTIGLDFEGLIADVKGAPNGSVFLFHACAHNPTGVDPTQEQWKQISDVVKEKGHFAFFDMAYQGFASGDTDKDAFAVRYFVEQGHNIALCQSFAKNMGLYGERIGAFSIVCADAEEKKRVDSQLKIIIRPLYSNPPIHGARIASEILNSPTLYKQWLGEVKQMADRIITMRALLKDNLEKLGSKHDWSHITSQIGMFAYTGLTAEEMTRLAEEFSVYATKDGRISVAGITSENVGRLAEAIYKVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBM9</accession>
    <name>S0EBM9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable tRNA-guanine transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_08774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433256.1">
        <property type="nucleotide sequence ID" value="XM_023580487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBM9"/>
    <dbReference type="STRING" id="1279085.S0EBM9"/>
    <dbReference type="GeneID" id="35402250"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08774"/>
    <dbReference type="HOGENOM" id="CLU_022060_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002099">
        <property type="term" value="P:tRNA wobble guanine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT71177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="302" mass="33609" checksum="3242AF11DE7F972C" modified="2013-09-18" version="1">MVSLLKLATITEKGVEFLSPHDGTPMLLTPEHSMSLQNSIGSDIMMQLDDVLVTTSPDKARMREAMERSVRWLDRCIAAHKKPESQNLFCIIQGGLDLDMRRECCREMLARDTPGIAIGGLSGGEAKADYCRVVAACTELLPDLKPRYVMGIGYPEDLVVSVALGADMFDCVWPTRTARFGNAVTKHGVLNIRNKKYATDFGPVEEGCNCMVCKPTADGGMGVTRAFVHHNASKETVAAHLLTIHNVYYQLNLMRQIREAIMEDRFPTFVRQFFAWLYADKTEYPEWAVGALKGVNIDLTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC02</accession>
    <name>S0EC02_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434554.1">
        <property type="nucleotide sequence ID" value="XM_023581947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC02"/>
    <dbReference type="GeneID" id="35405807"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12351"/>
    <dbReference type="HOGENOM" id="CLU_1825389_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="149" mass="16448" checksum="B689B9AECA3D914D" modified="2013-09-18" version="1">MSGINNETPPNALKPWQVRALAKGRTPLPEIPGCRPWLETSSTQDMSGSGQQALVTTGSFSASIPSTPGAALSVSEAETNSNPGYKFWNQDEMKRLIELKREGKSWRDISDHFPGRSVEALKQTYHKRRATAEEQMHPVAKEKEDQAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECL5</accession>
    <name>S0ECL5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_06059</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432197.1">
        <property type="nucleotide sequence ID" value="XM_023579342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECL5"/>
    <dbReference type="STRING" id="1279085.S0ECL5"/>
    <dbReference type="GeneID" id="35399537"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06059"/>
    <dbReference type="HOGENOM" id="CLU_020273_3_1_1"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT70118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="235" mass="25328" checksum="D00C1B94862995DE" modified="2013-09-18" version="1">MPATIPQNKFDSIPESIEAFRNGEFLVVLDDPSRENEADLIIAAEDVTTEKMGFLIHHSSGYVCAPLSPAITTSLDLPQMVPNNQDLRGTAYTISVDSADPSVSTGISARDRALACRTLADPNARPDSFRRPGHVLPLRSRPGGVRQRPGHTEAAVDFCRLAGKAHAAVICEIVDVGEETPGQALRHNHGMLRGEDCITFARKWGLKVCTIADLVAYIEKTEGKIEANGAESNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0ED78</accession>
    <name>S0ED78_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to hydrolase related to dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434628.1">
        <property type="nucleotide sequence ID" value="XM_023582033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ED78"/>
    <dbReference type="STRING" id="1279085.S0ED78"/>
    <dbReference type="GeneID" id="35405884"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12428"/>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="247" mass="26879" checksum="A2702A216453CAEF" modified="2013-09-18" version="1">MASHPPAACCTIANLHEGTPKGNVVKVGNVTGYLAKSPKESKQAVLYLPDIFGIWQNSKLMADAFAAEGYTCLVVDTFNGDPVPSEMPEGFDIMKWLGEGSDGKNPHTAEAVDPIVVSGIEYLKSIGITQIAAVGYCLGAKHLIRHYKDGINVGFIAHPSFVESEELAAITGPLSIAAAELDDLFTVEKRHESEGILSKSKQDFQINLFSGVHHGFAVKGDMKDKRQLFAKEQAFNQAVSWFKRHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDE8</accession>
    <name>S0EDE8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to HNM1-Choline permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434723.1">
        <property type="nucleotide sequence ID" value="XM_023582145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDE8"/>
    <dbReference type="STRING" id="1279085.S0EDE8"/>
    <dbReference type="GeneID" id="35405984"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12528"/>
    <dbReference type="HOGENOM" id="CLU_010270_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="487"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT72645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1044" mass="114720" checksum="629293ABBF9024D1" modified="2013-09-18" version="1">MSLDMASPAIDNEKHLGSQNQDEQNLERHGYVQQTKRNFSLTAMVATCVNLMATWEALSSTLAAGLVSGGAVSLVYGVIVAFFGSLCSASSLAELASSYPTAGGQYHFVAKLSPKTSRPLTSWLAGYISTLGWIASAGSAPFLAGTQIQGLLVLNYPDSYVFQRWHGTLLFWAVLLGSACICIFCSNKLPLIEKLTLVLHVTFFIAIIVTMAVTSPTKHSAEWVFSHFENNSGWGNDAVAWSIGLLSSCYVLIGYDGATHLSEEMNNAEMGVPRAMVGCLLVNGPLGFAFLLIILFFMGDISAALATPTGFPIIEIFLHMTGSVAAATTMTAMITVMACLSTVPLLTAAARIMWAFARDGGLPFAERIASVDKRRQIPTVSIVVVSFLLMLLSLINIGSTTAFNAILSLAVVSLQASYLLPIILLIWRRLFRPDTLRWGPWRLGKAGLPINIIAVIYLMYTCIFLLFPPYQPITPVNMNYAPVVLGGALVFGCIYWPLRKLKCDEAEPACTRCVKSNLLCPGYKRPVKWSTKYEIDYGIHSYAGPGSGPSSGIGNSPSSPFETENVLVLYSPQEESSKLLTHYFASACQVLSSFDSPKNPYRSDLLEFIRNSPIVFNSALSASAAHLSQQERDTSLIPLTFQTEAISHISRELAEIHRLIPLTASTAPTIKDDLMLGITLIGMTSSWHDPSSLGLCHFHGARKVFRIWISQFNLTDLQFPSHRVQRLIVSSMVYWEVMASCLIDQEISALSYLDVFSVLPPSTFCYPCPWTGVGTNILISLAKCMTLVRQKRRLISYNYSREDDIDISSRTIDLLSQAFTLSLDIDHCQIPTPATVQSTGDLRTPSDHLCKIAKCYQLVGRLELDRAFPEVAQCIQDGQNQGKILSRHILELAVKILEIMNTIPQDSRTIAIQTIIFLAAGSALGSTSNTNTNIKVLVANWRRFVLERLRRSFLSLKLQTINWAAAVLQRVWAQMDSVAMDGPDSTSYGRSPILRVHWIDVMTEARLETILGYSLHAYAHAVSRKSEKAVTHMNLGESDNGYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDG3</accession>
    <name>S0EDG3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432512.1">
        <property type="nucleotide sequence ID" value="XM_023579727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDG3"/>
    <dbReference type="GeneID" id="35399883"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06406"/>
    <dbReference type="HOGENOM" id="CLU_536456_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="26"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="527" mass="62194" checksum="951EC354F1F074D4" modified="2013-09-18" version="1">MTQTDRNPRFRVQDDASNTKPKLENFHLFRFLPYDLRHTIYILATPPRVVRVEEGPVNPKEKRAWIDQDYESYFDYAFENFYKEKLVKMPVPKLHPDLAAFAHNWRHRIPWDSYNRQYKQTCLETYGFTSNSPVYEPWQPSEETPRIPTDWLVDFPELAFELTRKCALYSDAEIPVFLHVCSESRQALVNWGYRLFFATRTTSPRIWFHPERDRLYIPHTVETFPRAYDRYYGSGLPGEAHTPYPCPEYSLLLSGCHWDIGQYRVDDLKKVRNVILESPSTGKDQDALIRELQSLLPLLSGLNELLLENWGLEEFGDWFYPFRGSHTVEVKTPASSVACIPVEDIDAIGYAFWERSRANDDNRLGPLCYTGYRNSDFNEFLENPSRSQSYHVAHAEAVKTELLEWKSDLATSKKPRIPTICHVNICPDSFSKVYLANRHRFWKALESLDHMQVQDLDFREKFSLRMSNCPPPFRIHWRQLDWDRDWPDTVEIARLTDAMGIDWYTEGTLQAWYLTRFEVPEPQCIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDX7</accession>
    <name>S0EDX7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">aromatic-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_10200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435209.1">
        <property type="nucleotide sequence ID" value="XM_023567814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDX7"/>
    <dbReference type="STRING" id="1279085.S0EDX7"/>
    <dbReference type="GeneID" id="35403666"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10200"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="194"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT73131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="546" mass="61384" checksum="9F5355104E212C33" modified="2013-09-18" version="1">MPLLVVRTRQLSDMGHSTTTEVSGSLGGSQVKIELMRKRRATATKIRPGTAAMSDSDMFKLPADGKPLAKRWETHFSRESNRPPCVLKQAAGYIKTPGLISLGGGLPSSEYFPISEIAMCVPTAPNFSEKQHLLDSRASGAQIARIGKYDTRDGTSDFDISIAFNYGQATGSPQMMRWVTEHVDLVYNPPYADWGVCLTTGSTAALEQTVRMLCDRFRNDSILTEDYTFATAMETFVPQGIKVFGINMDEQGLLPGHMDHILETWDEGDRGARKPHLLYTVPSGQNPTGATQSLDRRREIYKVCQKHDMFIIEDEPYYFIQMKPYTGRGTEVVGNETVDDFLTRLVPTYLSMDVDGRVLRMDSFSKVLVPGSRMGWITASKEVIHKYLCHAEVANQGPSGISQLIIWKLVDETWGHEGYLRWLIDLRTSYTTRRNALLAACEDYLPTDIVSWVPPASGMFLWLKLDHTKHPDYQCRSLEEIEVEIFKNSIDQGVLFARGSWFRAEPHEELKELFLRVTFASAAEGDMCTAVQRLSAAIKKSFRIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EE11</accession>
    <name>S0EE11_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434140.1">
        <property type="nucleotide sequence ID" value="XM_023581442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EE11"/>
    <dbReference type="GeneID" id="35407394"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13940"/>
    <dbReference type="HOGENOM" id="CLU_1165903_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="238" mass="27496" checksum="9970120DDDDE2B1D" modified="2013-09-18" version="1">MDRIRSYKDLKPPFDNGRFPLYDAPLKPLETASRRSHLGKYIVRVMPSFSKFIDVEWKKAESKICENLASERYMSVSEPWFEYQVDRIVYLHFFATFKAFFDRDVPGLPWEDITDKYLKSQQDKNSSVYVEYLKRQESQAQKSNPVEKSTLAQDTNEMGNVEGPATERRVLTSSKLNPRALEFRPPQDGGRRQTTGEPSGRAWVATRSGKRGKRPVNRRGKQEGDVDMDTGNMARLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEF2</accession>
    <name>S0EEF2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to glucose transporter-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_09973</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435419.1">
        <property type="nucleotide sequence ID" value="XM_023568065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEF2"/>
    <dbReference type="STRING" id="1279085.S0EEF2"/>
    <dbReference type="GeneID" id="35403440"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09973"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="16"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT73341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="503" mass="53619" checksum="FE996B34FA7C47B2" modified="2013-09-18" version="1">MAGIRLRDVSGYLILLIAVSTLGSLQFGFHLAELNAPQDVITCRKKSISALDKIKGLVYKPKDDDAGSGFMPHCIPMDEASFATISSIFMLGGLLGALASGPFSSKRGRLPAMRITGLLYLFGAAIETVAGSVFVMALGRLFAGIGAGASTVVVPLYISEIAPPKERGLFGFMTQISINFGILVVQTMGFFLSYGSAWRWILATGVFIATAQTLGLFVVPESPSWLAAQGNAPKARRTLQRIRGNGYDIHEETETWDSDDRDASEEDGLLQADSASESPSKNRTEHLGFFEVLKDPDTRPAIVAVVGIMFAQQLCGVNSIIMYSVSLLADLLPVSSSLLTILVSVVNLFTTIACAPLPDRLGRKTCLLASIIGQGTSALILAISIIFGIKILSAIAVVAFVGFFAVGLGPVPFLISSELVGQEAVGATQSWCLAANYAATFLVAQFFPIVNSALNDLLGGHGWVYFIFAGLAAGSAIFVFWNVPETKGKKDVDEVWGRTRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFG6</accession>
    <name>S0EFG6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434660.1">
        <property type="nucleotide sequence ID" value="XM_023582071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFG6"/>
    <dbReference type="STRING" id="1279085.S0EFG6"/>
    <dbReference type="GeneID" id="35405918"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12462"/>
    <dbReference type="HOGENOM" id="CLU_024334_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="715" mass="80682" checksum="37A64FEF2D71B99F" modified="2013-09-18" version="1">MSWNRYDLGQANIFYDETHPLLSSFMLPPHVEEVKRCLTDFSCLINEKKESFSKISKDMAEYLEQGPNSDRTCKAAEMIQHEVVSKVGGGYEENVWRGIFEKHFFDPLTDSLSTSKEDSRRVSRNNYYYDQVIRSSDQIWTLFEPDKKATTTRLRPVKSPKPDQVFFLPIYHHHNNTGLPKVVDPKARQWNHAGDSRAMEPFTWWTLQRLNKVGLEPSPFRIFDKSPLGANLRCYPWLIVEHKREKDQNEALERVVICQAANAAACAISLVQQTAQYAVRLPRHAHIPPIPAITTIGSSVTVWLMYFAEDFDAPCSRRDTDEVLTRRRNEGYVMRAIWKGDVKNHTDIMAFQMIIDNAHTWATRVFKPTVASYIQQWKHIHSEQKPGTMTDLLQTSESHALRERNIEQRRLVAPLIRDLLDAPVGMELDDMAHKKVTPLFLGMLMHQICSMERASISSQIEKAVTERLQVIVANGPTLTAKVEAVHRVEATAKLPIRGHHDETAQTASSTQESEMEEVDDDDPHDSDYNPTNSESRSRSPSDAHLHDGDTRSEVAVSVASTSAFSLRSFSEETTVLWKHPSDPETPKAGTSSKKESERADILDRQSLQLSEGSDDETPKPSTAGHKLDFRFSSPISGSAFERLGGNSLDGSPVFAGRSPPSQTKWPRGRIFDPPKTQRSPMHRSGISPSPPANAKAKECIDLTSDSQADPSNTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EG92</accession>
    <name>S0EG92_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to alpha-1,2-galactosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_09881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436094.1">
        <property type="nucleotide sequence ID" value="XM_023568167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EG92"/>
    <dbReference type="STRING" id="1279085.S0EG92"/>
    <dbReference type="GeneID" id="35403348"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09881"/>
    <dbReference type="HOGENOM" id="CLU_021434_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000149">
        <property type="entry name" value="Alpha-1,6-mannosyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF10">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT74016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="320" mass="36839" checksum="E7D05CB68D6F763F" modified="2013-09-18" version="1">MHFAYPPRKNSNPPPFKQRSSQIPPILRRIRKRTAVLLLLGALGFIFFLFGLKGETPYREHVPSGSPPVVLVTVLDNTQYNEAYLESIRHNREQYASRNGYETMIVRASDYDTGKFPRSWAKIIAMRHALSKYPDATYVWFLDQNAYIMELDKKLEEQVVNPAKLESLMIKDWSIVPPDSIIKTFSHLKGEDAGLVISQDETGLVTNSFILKNGEWAKFFVETWMDPLYQSYNFQKAERHALEHIVQWHPTILSKLALIPQRTFASYGRNKEGNAYRDGDFVTLLVDCTVTGPTSCDKQSHFYLQQLKNKFGDVSVKKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH08</accession>
    <name>S0EH08_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_10363</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436394.1">
        <property type="nucleotide sequence ID" value="XM_023569137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH08"/>
    <dbReference type="STRING" id="1279085.S0EH08"/>
    <dbReference type="GeneID" id="35403828"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10363"/>
    <dbReference type="HOGENOM" id="CLU_003041_26_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="144"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="352"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT74316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="607" mass="66645" checksum="C1E60240EEFB4549" modified="2013-09-18" version="1">MQRFRLPINNILQHPRQLLPLTTLFASQPITPFPSFLMDGGSRRRGGRGGNRRGFSSRGGGRGGGRSNQPRNPQIKTENESPDVEMASPSPAPAPAPPLTEEPTSRRFDSLLENNKVNPLIVRTITNDMKFEFMTPVQAATMDELLPPNRSDCLVQARTGTGKTMAFLIPALQTMINQNRAAGDGISLLVISPTRELALQISAEAKRVLQGLPKYRVQVAIGGTNKDREERAILAGCEILIATPGRLLDHMSNEDIVYSMRKLNTLVLDEADRLLDMGFMKDLRDIVGRLPDKTKSDRQGMLFSATIAPHVEQVAGLVLSPGYKFISTIPAGEANTHERVPQFLVQVPTFADVAPAMVGCIREEATRGQAFKAILFAPTAAIADFYGRLLEDLPGLPPVSILHSRMSQNKRTKITNDYRTARSAILVATDVVARGMDFPGVTTVIQVGMPADKQSYIHRLGRTARADAEGRGILIVCDAEGFFPKYSLKEINLIAREADLSPSQDVIEVAEKMEDDEKSRVYQAWLGYYNSHMKALRWDKEELVRQANVYAREGLGSPDVPTIQKSTAGKMGLRGVRGLNTVADRPRQKHGATGGHGDNGRGKRGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH94</accession>
    <name>S0EH94_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436222.1">
        <property type="nucleotide sequence ID" value="XM_023568244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH94"/>
    <dbReference type="GeneID" id="35408273"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14906"/>
    <dbReference type="HOGENOM" id="CLU_128838_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="111" mass="12462" checksum="2E23E2FC94E6AA0E" modified="2013-09-18" version="1">MCRMMIFRGHCTCCDQPQTWVDLTQELSCLEAKNSGWFGGCRRGILVQEHDFNQECSVCHEEDEGVGGLDESHIMPFQQTSQTQTQTQSSLGKRTAGERGESSDASKKQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHQ1</accession>
    <name>S0EHQ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Related to pisatin demethylase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_10212</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436248.1">
        <property type="nucleotide sequence ID" value="XM_023568968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHQ1"/>
    <dbReference type="STRING" id="1279085.S0EHQ1"/>
    <dbReference type="GeneID" id="35403677"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10212"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT74170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="554" mass="63012" checksum="17EB8AFBF21907B3" modified="2013-09-18" version="1">MDHVMMVEPKSPEALVVSFTSGCLLHILFYRRGEWDTLALRILQAYATLPIIVIGLLRLAEFKGWQHGNNLSAASVLLLEGAHILGLITSILCYRIVFHPLNKFPGPLYARISNFYPTYLTTKNTHLYEEVEQLHHQYGDFVRLGPTQLSITHPKAIDAIYSAKSPCTKGPFYNILNPRISLHMIRDHKEHSARRKTWDRALSSKSLRDYEPRVTKYTTQLLDRLNEMQGTTINASDWLNFYSFDVMGDLAFGKSFNMLRDGVNHYFLSSLHGSMKMVGALAHISWVIPILKLIPAVNSEDRQFWAWISGQVEERSKMKPDNPDVFAWILEEYERNPKTHQAKLNVEAEAYLIAVAGSDTTAATLTGLLFELATNPSQIIKLREEIDQYFMDREHADHTSLSNLIHLNAVIDESLRLHPPVPSGLQRVTPPQGLMVGDTFIPGNTIVQVPMHTIQRDERNFARPSEFIPERWTTSPELTKDKTVYAPFSIGRYSCVGKQLGLMEVRYVIAHIIRAFDVRLGQGQTKEGFLKSKMDTFTLATPNLHLVFTPRPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI44</accession>
    <name>S0EI44_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to lipase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436408.1">
        <property type="nucleotide sequence ID" value="XM_023569155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI44"/>
    <dbReference type="GeneID" id="35403843"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10378"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="429" mass="46654" checksum="06FFA3C2B164C064" modified="2013-09-18" version="1">MSSLEWLLDLCTVAKATGRNVVTDHTPLEHQLPPSKDPWYSAPDGWENRQPGDVLRIRSASNLTSIVDGSGAVYHILYRSTDSRGHPSWAVTTLFISTSLYQSPSRKAAILSYQFAYNTCNVDSCPSYALSGVMAKSEPNLGIKSSTSLITEMLSFGWIINTPDHLGPKAAFGTSVQAGHATLDALRAVHNLLSLGDNSDFSTTIWGYSGGSIATFSAAELQPSYAPELNISAAVVGGLVDDISAALDKINKSPIAGTLIALLLGITAQYPEERAYLESCLVPEKRDDFMAAVNTEVTQNVGKYSGQDIYPFFKGGGADLRAPTLQELYDKQAKLGYRDTPTIPMFLYKAIQDQFCTIDLTDATVDRLCEKGAEITFERNTVGSHVSEIENGKPRAFGFLRSIFDESYECPASKRNVMDVTVDVSLQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIB2</accession>
    <name>S0EIB2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436473.1">
        <property type="nucleotide sequence ID" value="XM_023569228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIB2"/>
    <dbReference type="GeneID" id="35403908"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10443"/>
    <dbReference type="HOGENOM" id="CLU_1496326_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="180" mass="21090" checksum="5290F4558B58A0C6" modified="2013-09-18" version="1">MADNETRETNTTENRVLDGLSEHAPQNKSKLLPQDEREDSDSEEEHTQEDGSEENEPKSDRAKEKTRSVGDSHKKHSCKKESHKRDPSKKHSHKKESRKKHSHKDNSVSKIDTRSSSMGFSDVYTVRTLKVMWNKGFADLKDVQEKLEKLDKKKKKLEEEEKELKKWLNDLHENIKKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIP0</accession>
    <name>S0EIP0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable general amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436954.1">
        <property type="nucleotide sequence ID" value="XM_023569790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIP0"/>
    <dbReference type="STRING" id="1279085.S0EIP0"/>
    <dbReference type="GeneID" id="35404412"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10948"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF39">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="37"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="576" mass="63519" checksum="DED9084355D677E7" modified="2013-09-18" version="1">MTASLEKADGDENISTTVADHAVVTMQQTRRGLSPRHVQLMTIAGGIGVGLFVGVGGVLSKAGPLPLIIGYLIYGLGFIWPTMLNVAEMVAWLPIRGSIYELASRFVDPALGFAMGWTYFYAGAMLVCTEYSAVATVMQYWNTDINPAVWIAIALSVCYFMNMVAVRWYGEAEFVMGSTKILLILGLIMATFVTMVGGNPHHDAYGFRNWKNGDMAHEYYAEGATGIFLSICICVRYAVFTIGGPDIISLSAGEIRNPRKTIPKVAKLIVGRILFFYVVGILAVGIICNSRDPRLLGAIENGEAGAAASPWVLGLLRLDIRGFLPGLINFLILLSGWSCGNAYLYSSSRTLYSLAQDGQAPKIFLRCTKSGVPWVCVTAVTAISLLSFLVASNGASEVFSWFLDLTTVALVVNFTAMTWVFIGWRRALKAQGITRQGENNFKKSLFKRNSGRQPVPGIVFPFTAPCASWTPYLCLFIGGSTSLFIGFDIFQPWSLKGFITSYFGLAWFFFMFIFWKVFKRTKFVTPATVDIFADGKKQAVDEECRFWEEGFGDEAERDVLAKKHVVVRTWARFWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ37</accession>
    <name>S0EJ37_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to 5-oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_11086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437089.1">
        <property type="nucleotide sequence ID" value="XM_023569944.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EJ37"/>
    <dbReference type="GeneID" id="35404550"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11086"/>
    <dbReference type="HOGENOM" id="CLU_002157_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="541"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="742"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT75011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1287" mass="140064" checksum="E2B4C8CC50EDF5E3" modified="2013-09-18" version="1">MGDIRVSIDRGGTFCDVIATTGADGDKPFIFKLLSEDPSNYPDAPTEAVRRVLEKYTGRTIPVGEKLDASRIASCRIGTTVTTNALLTGNGERFAFATTKGFKDVCVIGDQSRPELFNLEIRKPAALHSTVVEIDERITIEDYDLNPHKKSTVNTEGGPDLVRTPSGEVIRILKRPDERVIRQQLEALRKQGYISLAVCFMHAYLFPDHERMVARIAKDVGFIFVTISSETSPLINFLRRSNSTCSEAYLYPIIRRYVDNFEAGFRIPPQRVDFMCSDGGLKLSDKFRGNEALLSGPAGGVVGTAKCFDVNEGTPLIGFDMGGTSTDVSRYDGNYDFLQQTTIARRTINLSMLNIATVAAGGGSILFARNGLLAVGPESAGAHPGPACYRKGGPLTVTDANLFLGRLVFSSFPAIFGQSGDQKLDMEIVTRRFEHITQDFNRQTSQNLTPEEVASGFLNIANETMSRPIRNATEARGFAPESHDLVSFGGAGGQHACAIADKLGITRVIIHKLSSLLSAHGIAHAELQYEVFEPFAAELDAKAMEGVKTLLLTLKSKVTEELVSQKAAPESLVFDEALVLKYFGTDTNLSISKPADGDYAAAFTAMHLREFAFSMDRPIIIESVKVRGSGSTSAPSHETSASEELASSKRMVFSDYTTRQKVYLDGSWQDTRVFRLCDAPEGSLINGPAIIIDETQTIFVESLFKAHVLVNYVVLEKTLSEEQSPNISISQTLSAPQETMSPIQLSVFAHRFMAIAEQMGNTLQRTSISSSIKERLDFSCAIFSPEGKLVANAPHIPIHLGSMQFAVQAQHRHWNGKLRPGDVLLTNHSSWGGTHLPDLTVVTPVFVGERIAFYVASRGHHTDIGGMGITSMMPESRSLWEEGIIVSSMKIVSSGEFLESEVRAAFEKVSTYPGCSTTRRIQDNISDLKAQTSANQRGITLLKNLCNEYSLEVVHKYMTGFQDNAELAVRAFFRKLAHEHPAPLSATDYLDDGTAMKVRISIDKNTGSAIYDFAGSGPQTWGNYNCPISITHSAIIYSIRCLVNLDIPLNEGCLAPCDIRVPTGSILNPTPTVAICGSTLASQRVIDLVLRAFGRFGASQGCANALGWGMGGKNLVTGEIEPGWNYGESIGGGVGAGEGYKGESGVHVHSTNTRQTDSEVIEKRTAVLVRRYGIREGSGGNGRWRGGDGIVREIEARANLKFSILSDRRVYRPYGMAGGHGGRQGKNLAFKFNEDHELEAINLGGKAIVHLQPGEYIQVNTPGGGGYGTPGDEEVDQEFDNFHKAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJD4</accession>
    <name>S0EJD4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437184.1">
        <property type="nucleotide sequence ID" value="XM_023570061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJD4"/>
    <dbReference type="STRING" id="1279085.S0EJD4"/>
    <dbReference type="GeneID" id="35404655"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11191"/>
    <dbReference type="HOGENOM" id="CLU_009941_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="755" mass="84598" checksum="02DE774C213AFE6B" modified="2013-09-18" version="1">MDNDDPTQPEQTAQAPDAGLACNCCRKRKLRCSRETPICEHCRKTGQDCVYETKRARPGMKGGAIENVHKRLDTLERTISKQQKELENLRDKEASTTQASSQQEAVDRQSLLSSLAREICKLGNPTLTASPEASIDSTCKRRRTEKHVGYRERSQYAVNQPGLPDDAILDLVIDAYFRQIHPWIPMIHEARFRQRRQDHGDDRCLLPVLQAMMLSASYHVPRRDIAEIAQSLIDDQEAVRDWVVSKATKSLTVENLQALIIICFRDIGDGEECRAWSLIGALTRMAGYLQLTIESEEADRSSFSQPNTSLNPPQGWTEAEERRRVFWCVFNLDRFCSFTTGWNTSLTSDDVNRRLPCDGISWRKEESVSTPYFGIWDKSAARIGNPIAFLPSHSATVPATTDEGGFTPSEATASPGAAASSVDMSTVGAFAYCIEATESLSRVTSYFLQQKVNIKDHNDLSGWLTRFKELDVRLVHWKMLLPKKWKVNIAQQSSRMDPNLTLAHVTHNASMILLHQPIAFPPLNWTFRTRLPSFCSLDTCQAAAIEIATITNHYLQIAEHIGPLNNQYSFCVYLAARVLLLLWRCHATESLSSEFWVLIQNLETMAERWAGPHQLGPKENLASKYQAVLVDLHTRCVREASFNINPSAYTTEVNHSRSISKLLNAAPRFQGHQLARHPAEENGGPSFTGNVSANAYYPGTTSSIANDQEGQSCSVGSGDLGMISQMLLDTEFIDMDRIISFDDGIFGTEHESGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJI3</accession>
    <name>S0EJI3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437027.1">
        <property type="nucleotide sequence ID" value="XM_023569873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJI3"/>
    <dbReference type="STRING" id="1279085.S0EJI3"/>
    <dbReference type="GeneID" id="35404487"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11023"/>
    <dbReference type="HOGENOM" id="CLU_096188_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22690" checksum="692CC55D6F9B6FE8" modified="2013-09-18" version="1">MADSSSSASPQTPEYYVGSFPAPGLRQIVRHITGHREDGKAHFLTSDHGEHYRFMGENKAVANIIYSTRETPVNLNDDTDVVKAKQEEPPFHYRNGSIVRMIDFGPGVESPFHRSLTIDYGIVIEGVFELTLDSGEMRIMRQGDVCVQRATAHKWKNITGNETMPGRMMWILLDAEELSVGGNKVEGYLGTLEKEYQGRGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK02</accession>
    <name>S0EK02_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434796.1">
        <property type="nucleotide sequence ID" value="XM_023582237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK02"/>
    <dbReference type="GeneID" id="35406067"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12611"/>
    <dbReference type="HOGENOM" id="CLU_1722521_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="152" mass="18078" checksum="DF08A72645D469E3" modified="2013-09-18" version="1">MQENTKDKGLGDVIWFHSEPFAPPIYGLKGLIHRKGDYEPWRQVADMERDIFCVTAESWQPLVTNWKPLHVEAEDEWGRHFIDDVTNIAVEFDPSWYQTIKKFSPDNRVKDYPPSLAFLIRLLLDQDDRLPPEELMKFVVRRDNLRPRDLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK16</accession>
    <name>S0EK16_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434811.1">
        <property type="nucleotide sequence ID" value="XM_023582254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK16"/>
    <dbReference type="GeneID" id="35406081"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12625"/>
    <dbReference type="HOGENOM" id="CLU_1434791_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485711" evidence="1">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="199" mass="21540" checksum="55A71442A1208AD4" modified="2013-09-18" version="1">MARFILILATLATAAFASATADKALEKTPVKVTEVTYKVGEVAQCITLSHLQALGHTFTNLNGTGDYKLPEIPTTYINDPTACIPESLFDQYFEPIVAISKEQNLLESFDAEKVHSRDLEVRARNCPQIKDAALGRVHSWSCDSAPHPSSCRSCANFSSINFVAACVACAAKANQESIFCCAAAATTFATYYSQVCLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK82</accession>
    <name>S0EK82_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437282.1">
        <property type="nucleotide sequence ID" value="XM_023570124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK82"/>
    <dbReference type="STRING" id="1279085.S0EK82"/>
    <dbReference type="GeneID" id="35404710"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11248"/>
    <dbReference type="HOGENOM" id="CLU_053725_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="82"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="333" mass="38977" checksum="9B27CE0BC0F81DAC" modified="2013-09-18" version="1">MDFLNRLLGRNTDTKYKYRGAKLPKEPLTPREIEEMHRKLHPDTHRDNAWEPEPTFDPRDWSVPYTQSLEEKLSAVGSLQDAQSESLLFSRLPMEVRMQIWRLVMGNHKVHLTVHRGRLRQSSFESENYQWLPQRGLLRVPLICRAAYMESIAYLYSDNTFCFGFGQASSKSALTLLDTMLPKQHVASMQRMEVGWHLYAGVSQYYDSHPQAWDITLDVPAPETETLWNNVSAELVKLSHLRTLRIVVWLSGDGRAQFMVMEKDMLAPLVAMGHLERFDVHLPWKQDDTEMWNDAPFKVSRRFRVKEMYGVSIPLLDDDFYWSGSATQHRIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKG1</accession>
    <name>S0EKG1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436460.1">
        <property type="nucleotide sequence ID" value="XM_023569214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKG1"/>
    <dbReference type="STRING" id="1279085.S0EKG1"/>
    <dbReference type="GeneID" id="35403895"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10430"/>
    <dbReference type="HOGENOM" id="CLU_010112_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="808" mass="90504" checksum="FD1A2C1F42FF5C9E" modified="2013-09-18" version="1">MGCFSRFSGWKLTAVYLTILVSTLTTLLFVTLFVSLFGLKRDDGDDALTSGRDAGDALGQSVLYKGNCDTTSKANLWIHLLINIVSTGILASSNFFMQGLVAPTRAEVDAAHRSGHWLEIGVQSLKNFRFLGWRKVLFWSLFSMSSVPLHLVFNGCVLESKGTNGFTVMIGSQELTQGGWKGLPSITAAYFDRLNYSDQSQGDGNPESLEKLKPINDSFVVNSTSENWVELELSECIHRYNNPEQALTHWRHLMMIIYDYDDIYRNETVGWKRADVLMNTTNTTDLNVMNPLWSVDAFTRTGRTSEASGSNNQYMSNPEPSYLVSTLPDGYGNTGPSSRSYMNVYGMWDMQGTRNVFDPQSGAIITDPTVFKSKYRVMQVDRCYSEKYEAPCRLSIANSLLLIVCIMCLFKTVLCLLVLKLRVWGDENPLMTPGDAIASFISRPDEETRGMCTLTMEDLRRTAKPTPTRLGETNQNYKWLQGPRQWQNNSPRRFGKAVPRNIWVLSSLLIGCSLIVASVMLSIAIQGQALKNSKFMHAPQNEDVKNDQLARLPLISLTMVANTPQLILSICYLAYNGLFTRMLAEFEWSKYSVAFRSLRVTEPRGSQNATYRLQLPYRFSIPLIIISIGLHWVYSNCIYVSNYEAYAPGYPYSRTVTVGLQFSSKAILVGLLASIGVAITPLFLAFVKLPGVMVIAGANSAVISAACHYPSTKLKSLSRATSKMSMRSNEYDSMSARLIGDEEVEELRDVSRRKIKWGRMSMGKSDESSVGHLGFGTEELDIEKPVEGEYYSGVKDVYDEGLRRMRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKH6</accession>
    <name>S0EKH6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434981.1">
        <property type="nucleotide sequence ID" value="XM_023582447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKH6"/>
    <dbReference type="STRING" id="1279085.S0EKH6"/>
    <dbReference type="GeneID" id="35406255"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12799"/>
    <dbReference type="HOGENOM" id="CLU_077442_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="214" mass="23578" checksum="E0CC4A4F954CA3D8" modified="2013-09-18" version="1">MKFTLFSGVPSQSPLPENPLSKDFELIALPGPDIWRTPFCAGGRDDFNGPIYATPIPLSSFKSAKVTISSDFPGNYFQGGLILFMPETVPITQTDSQLRLEESPRTWIKAGIEKVDGEFFASVAAAKPYSDWSLVRLGESCATFEMEKANGSLWIYVTGQDGRRTPVRKLTWVVDVAPENDIWIGVAACMPKGDESQSGGMLKVHFRDFSITTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKL6</accession>
    <name>S0EKL6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to flavin-containing monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437584.1">
        <property type="nucleotide sequence ID" value="XM_023570477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKL6"/>
    <dbReference type="STRING" id="1279085.S0EKL6"/>
    <dbReference type="GeneID" id="35405026"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11565"/>
    <dbReference type="HOGENOM" id="CLU_006909_5_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="389" mass="45356" checksum="A47878EAF15FA2F8" modified="2013-09-18" version="1">MSFSDQPFSYGPFVPHYVPRQYIETYFSTQKTDEYLSLNTTVEDISQLPAATKGVLKPWRLTLRKYDPLRHVDVWWQEDFDAVILANGHYAVPWVPRVDGLEAYMEKFPGRVIHSKFYRSPWIYADKRVLVIGNSASGHDIAVDLLQSVHQPLYQSRRSRGRLDGDEPPLGMEWKTVIKEYRLDGTVVFDDGSELEDLDHIIYCTGYLPSYPFWNSKVNGRPLFDYKKRKLINNYWHTFFQDIPNLAVVGMPRVLTFRSFEYQAIALARLFSGRNSISLPPKEEQKKWELDREKLCRQQGRKFHEIEWETGETFGWLEGFFKIAGLGTLSGEGRIPPVLSKDLIWAIEHVRKYPDPGKDDHNKRREGSQSESDGWDLVENTHKDLLSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKP8</accession>
    <name>S0EKP8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein PTH11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_10527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436550.1">
        <property type="nucleotide sequence ID" value="XM_023569321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKP8"/>
    <dbReference type="STRING" id="1279085.S0EKP8"/>
    <dbReference type="GeneID" id="35403991"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10527"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF15">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="143"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT74472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="334" mass="36901" checksum="2C6703C10B3EB3B5" modified="2013-09-18" version="1">MLDESATSVDPKGLGRVLIVVSIIFLILTGIVVILRCVVRLKYRLFGIDDGLMLIGWILHVTFTAVGMRAIYAGVGTKDKDLNAYLQVDGRKWMWIGQEIYSFSLIPLKASICVTLLRIAVTKTHRRIVWTTLIFTIVTTLYNAIGYVVSISAVVSDWICAVLPIFMLYKSHMRKATKVSVSIILGLAALASLCTIVRLPYLRAFAQPVNYLYNVGNIVLWSTLESGIGIIAGSLPSLRKLVSSRFHFDSSTGSSPTHITPFSGTSRAVITSQSVSAGRRTHRGEVGDNWEQLDDVEGASSQKIYVKVDLEMQSLERPETSRESHGSREDLVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELE6</accession>
    <name>S0ELE6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to D-amino acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437909.1">
        <property type="nucleotide sequence ID" value="XM_023570858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELE6"/>
    <dbReference type="STRING" id="1279085.S0ELE6"/>
    <dbReference type="GeneID" id="35405367"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11907"/>
    <dbReference type="HOGENOM" id="CLU_034311_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="331" mass="36833" checksum="B43AB2EAD04C3879" modified="2013-09-18" version="1">MEVGIIGSGIIGLTSALALVDAGYSVTIVARDLPGDDSSQQWASPWAGAGILPHPDYKGHDLQTETFKFYWALAHRDPTSGVQAVDVTEYYDDRDDDSTIWYKKMAPKYRRLPSKDLPATAKIGFKYRSMTVNPAVFLPWIKTVLDRKGVRFIRAEVKSIEEARSILGTKIIVNASGLGAFHLVNDQKVVAVRGQTMLVESDSHEMVMFQGSHYTYQIPRMYSGGVIVGGVSQAGNMDQNVDPAVRSDILRRMKLVAKDLYQDVDLSKHVMKDLVGFRPSREGGYRLEREGELIHAYGFNTLGYTYSYGVALKIRDLITSATEEEAVRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELL1</accession>
    <name>S0ELL1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to vacuolar membrane protein HMT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_11980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437974.1">
        <property type="nucleotide sequence ID" value="XM_023570939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELL1"/>
    <dbReference type="STRING" id="1279085.S0ELL1"/>
    <dbReference type="GeneID" id="35405440"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11980"/>
    <dbReference type="HOGENOM" id="CLU_000604_6_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="253"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="568"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT75928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="807" mass="90447" checksum="BF066AB90FE6BF7C" modified="2013-09-18" version="1">MPSILQVSNILHYSCSSVAVVFVSVVTILNAARTTGKTTTPRNYDRIAIALLILGYLAEGIATFVQESQQSKEPETIHLVVLGSLWAFIWSQRAAPRLLVLGTSLITLAFEIPLQIFSALNSQNDIYHIIQLASQTFRLLPLLFLMIYHLSNSGRFYTPDSEAEESQPFLQSNGHANGRACPSYGTETSSDTEVDDDEYISGSETEEDVIDIKRQRAKKLKEKGGWLGYLSDFSIFLPFLIPKKDRKVQLCILISLFCILATRVFNILVPRQLGIVADQLLAKQNPFHALFIWLIMSLASHDVVVGLIESLAKIPIKQYSYRSLTNAAFNHVLSLPMEFHSERDSAEVMKAIEQGEALTNVLDMLIIEILPTVIDLAIAFVFLYWKFNSYVALAMAIGSVLFVTFEVKATGWNLDNRRESTKSKREEVRVMHQAVQGWQTVTYFNMFNYEKYRFGSAVNKQLSAGLNFEKTDAYIQLLLNALIPCTFFTLATLVIYDVWHGASSPGDFVFFIQYWEYLVWPLKFLSHSYRQLMSDLVDAERLLYLLQTKPTITDKEGAKDLEKVEGRVAFHDVCFSYDPRKPTVQDLSLSVEPGQTIALVGETGAGKSSIMKLLLRFYDIDEGSITIDGYDIRDITLSSLRNALGVVPQDPLLFNASILENMRYARPSATDEEIYAACRSAAIHDKILSFVDGYNTEVGEQGVKLSGGEIQRLAIARVFLKNPPILILDEATSAVDTNTESSIQGALDELKRARSTFIIAHRLSTIVSADKILVIHNGQVVESGTHAELISIDGRYKELWNKQVGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMQ3</accession>
    <name>S0EMQ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable BRT1 protein, down-regulated by mating factor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT76071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438117.1">
        <property type="nucleotide sequence ID" value="XM_023570859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMQ3"/>
    <dbReference type="STRING" id="1279085.S0EMQ3"/>
    <dbReference type="GeneID" id="35405368"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11908"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="133" mass="14044" checksum="19049E741BB59E5A" modified="2013-09-18" version="1">MSSDLTTISTSEGCPAIGPYSQAVVAGSYVFLSGQIPIDSTGKPLQGSIADKTHACCKSVQAVLSAAGSGISRVAKVTVFLDDMKNFAEFNAVYETYFTHKPARSCVAVKTLPKNLEVEIECVALLHTQGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMR2</accession>
    <name>S0EMR2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to fluconazole resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11979</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437973.1">
        <property type="nucleotide sequence ID" value="XM_023570938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMR2"/>
    <dbReference type="STRING" id="1279085.S0EMR2"/>
    <dbReference type="GeneID" id="35405439"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11979"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="121"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="565" mass="62237" checksum="3055121BCFE40990" modified="2013-09-18" version="1">MEKIETAHSDHNDRRESHTSSHSDEESSISSSHHNHQNDDISRTYSLGDTEWQSIRAPNTGISMTRTVSRRESVLSRIRSRPIPVFTHPLAHVKTTEDQLVDFDGPDDPYRPMNWPNKKKILTTMLYGLVTMSATWASSSYSSGTAQVAKHFHVGTQVATLGTTLFLVGFGIGPLLWAPLSEVYGRRQAVLIPMFIAICFSFGSAVAKDFQTLMITRFFCAFFASAPVTNTGGVLGDLFLPSERGIAMAGYAMAVVGGPVLGPIVSAAVVQDPSLGWRWTEYLTGIVQIIFLTLAVIFVDESYPPNLLIYKARRLRHETGNWALHAKFEEWDVSISELARKFLVRPVQLLMTPICFLVALYASFCYGILYMQLGAIPIIFREIRGWGILVSSLPFICILLGAILGCGANVYNQLLYNKAYHAAGNRAVPEKRLPPMMVGSVIFSGGQFLIGWTAQKDIHWVVPCIGLVLLGTGFFTIFQAALNYLVDTFTMYAASAVAANTFLRSCFAAAFPLVVGPLYHNIGVGPGSSITGGFAALLIPVPFVFYIYGKRIRARSKWSKASVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPT4</accession>
    <name>S0EPT4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437751.1">
        <property type="nucleotide sequence ID" value="XM_023570673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPT4"/>
    <dbReference type="STRING" id="1279085.S0EPT4"/>
    <dbReference type="GeneID" id="35405201"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11740"/>
    <dbReference type="HOGENOM" id="CLU_499694_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="547" mass="59242" checksum="2619B3DDB230646C" modified="2013-09-18" version="1">MFSTLRQTFGDGDRLLSVEIAPPFDKDRTSMRTACERCRAQKSKCVSGENGCMLCVAKNRKCEYLVISRPQRRTSSVASGGPKSRSDDDDDEDDDNTNTVANQHKQAQQARRHKRRSRAQSMRQSSPLSTHLSSPKDQSRAVTTSQPSLQDNSNNIATGPDVGLEEAQQLFLDTLFPDSLGQIQSVFPQFEPDFFCNMAGVTPTATSKGREGHSGVGVTVEALTARGDSSKQSNHTSVYSSSSADSLFEYGIDPMDFLMDESRVSTTLAPSGAHDPKRITIEARPATTHSSTPPDSVATSTSSSSSCCCMMTAVSIYEAMQAQLVWGDPMAGPSAASTPSSTSAGSSYSSGPSWSGSDSGSGAGTAATTYQSTSPLMTQQTILKRQKMILLRCDSLVQCGTCWSRPDFVMLIMTMCDRILTSLEAVERFVCNRSDDDINKVSSNGTAAALDMQVMATPLRAGLEVSSLSRSSQMLQPGVGAWQIDDDDEMELVISLIKSRVTRLGNLITMAEGTISANAWPWHERLVQALRKRSNKLLISLSFRHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHF8</accession>
    <name>S0DHF8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable alpha-glucoside transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_02017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423585.1">
        <property type="nucleotide sequence ID" value="XM_023579450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHF8"/>
    <dbReference type="GeneID" id="35395500"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02017"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="70"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT61504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="488" mass="54311" checksum="7B5A42A9FFACC74F" modified="2013-09-18" version="1">MEKTISSHSVEHNEGLATHDTRDEKNNSNVMLGRAGSWEATLDEAQAANAHEHALTVRQALKSYPWAVVWSLVVSLSIIMEGYDTILIGSLYAYPTYARRFGEYQDATKTYQIPARWQSAMGSGPQAGAIVGAILNGFIIQRFGYRPAFFLGVVLMAAFVMVSFFGMSVELQAVGQILCGLPWGIFATIGPAYASELCPLPLRVYLTAYTNMCFATGQLIGAGVLKSFIEWDNDWAWRVPFALQWLWIPFLFVACIFMPESPWYLVRNGRYEEAEKSVLRLMATHEKPQAKPLVALMIHTNETEKRIAEGTSYFDCFKAADIRRTEIACVSFLGQITCGAQFAYSATYFFQQAGLDSETSYNLNLGGTGMAFCGTIASWFLMRHIGRRNLYLAGMSAMSMWLLIIGALATNTSNPAVKWVQSILCLIWLLTFSLTVGPIGWAIPAEVSSTRLRSKTVVLARTSYYLAQIVANVIQPYMMNPSAWNWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHV0</accession>
    <name>S0DHV0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423642.1">
        <property type="nucleotide sequence ID" value="XM_023571307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHV0"/>
    <dbReference type="GeneID" id="35395441"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01958"/>
    <dbReference type="HOGENOM" id="CLU_1959685_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="130" mass="14497" checksum="D67ABF338BD5FE32" modified="2013-09-18" version="1">MAGRNFAHSEMVLLNTIRGLFVQANLLLCESCGCKSFPGYTTCLDPDCEARLPSGMPSRKRALALSIFNFVLAPLRNHLPPPQGSRRIRRAIRYVVQIENARQEGAQTLAKLMHPDDLIAMFDLNNLMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DID2</accession>
    <name>S0DID2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to VTC2-putative polyphosphate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_01639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423947.1">
        <property type="nucleotide sequence ID" value="XM_023576473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DID2"/>
    <dbReference type="STRING" id="1279085.S0DID2"/>
    <dbReference type="GeneID" id="35395124"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01639"/>
    <dbReference type="HOGENOM" id="CLU_009308_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000002">
        <property type="entry name" value="Vacuolar transporter chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT61866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="769" mass="88440" checksum="8D260A1256D260AA" modified="2013-09-18" version="1">MRFGRTLRESIYPPWKDKYIDYAKLKSLLREDVADDDNQPWTEEDETRFCEEIFNNQLEKVAQFQEQRFNALKERVDAAFDKLKELAPVESSEDDGAPQKGEISASRLRTLESELDEITNEVRELKKYSNINYTGFLKIIKKHDRKRGDRYKVRPMMQLSLSQRPFNSETGYSPLLNKLSIMYFAIRQQLEDGGEQLPPLDLESQGETHNGERYTAHKFWVHPDNLLEVKTVILRHLPALVYSEQSAKELDGSDSPSITSLYFDNKQFELYGEKVNRKSEATSLRLRWYGQLATRPEIFVEQKTVDDKGGSQDLKFTIKDKYVKSFVNGEYNPEKAVQKMKRQSFAPEKIEQFQETVNNIQKYVKEKGLSPVLRANYVRTAFQKPADDRIRIAIDTDVAFIREDTLDPSRPCRDPNEWHRLDIDESEMTYPFKKMNQSEVNRFPYALLEIKLKEDSQRKHPTWVEDLMSSHLVHPTPRFSKFVHGIAALFEDYVNNLPFWLSDLESDIRKDPQKTFEEEEQRRAQRHEDVMAVGSLIGAGAKSGSYKPTQSSPVSKSYLAERMSKDSIAQALNRRTSTPANGEEAGESSSQQRSEQERSYGTLSSVIPGFSLSKYSRAKRASQQPLPEGVVAPTEWIKNMGELKVEPKVWLANERTFLKWQHICILQGGLAVGLYTAAGENTLASVIGLLFVLIAVFAGIWGYAMLRIRRTMIVERSGKDFDNMIGPMIISGSLMLVLILNFFFAYREAFGKFKDDQSSLGELLSEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DIH2</accession>
    <name>S0DIH2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424081.1">
        <property type="nucleotide sequence ID" value="XM_023578105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DIH2"/>
    <dbReference type="STRING" id="1279085.S0DIH2"/>
    <dbReference type="GeneID" id="35394977"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01492"/>
    <dbReference type="HOGENOM" id="CLU_053174_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44793" checksum="23FDB7E82513C411" modified="2013-09-18" version="1">MSSSGSSFTSSSLGRPPTYGRTYVSPVDSTWTPTSGISTISAPTTEGSGTGTSVLDLGPPGFQATIILFQDTPDERVVYLGPWEVVGSEQRRVLWQGSYQSELLEHFLPSDTPCDIYPHTLHSRHRPYYDPSDMERYLTFQEPHRIRYTTDEGVCIHDQYVTIRYEFTTVESSIQFQGDLRRKDLVDFYDVDVVWTNVHGRTDGFGKVKGIGAIQRLKLWRDRYTTFHSLSVCANKTDGQYREYDIHSFDGELRGRDDRAKQLRLNASGRRHTSGDDQHSHRRFSLPHRMRSRTRTNDSSEPRSLQQPTLDIRYLAIQFTERQAYRRFIETWLYCHSSDREFNGIPFPPNHFELPSPQILPGHSPDLPVSGWPNHMLESVPEPSDAAEATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJB7</accession>
    <name>S0DJB7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424670.1">
        <property type="nucleotide sequence ID" value="XM_023570518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJB7"/>
    <dbReference type="GeneID" id="35394331"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00846"/>
    <dbReference type="HOGENOM" id="CLU_2158439_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT62589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="111" mass="11724" checksum="535B7300DD50B5EF" modified="2013-09-18" version="1">MSSVVPHQGSAVGVAVEARQEAPELSQSRVTTYSHDNVFARIQSDGANNGRVAGVQPREYNIASLEAAMARYQPMHPVMAVSSNSNLAGIGAQFEGSLKSSSPVPVPRSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKX6</accession>
    <name>S0DKX6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425122.1">
        <property type="nucleotide sequence ID" value="XM_023573392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKX6"/>
    <dbReference type="STRING" id="1279085.S0DKX6"/>
    <dbReference type="GeneID" id="35393834"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00349"/>
    <dbReference type="HOGENOM" id="CLU_008374_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="825"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="954" mass="107272" checksum="9CDFF48DC7737AA6" modified="2013-09-18" version="1">MVSRTSSDGPPPGGGRQWKSLINKIPRRGIKIISQHAPETSTSDLDLHLRSPDSHSTNPLESQETHIRQLQTILQRMPRNFPTTPNHVDSAYKDFTKYKEQCATICRHILTEELGRGSRNDGDLPRRDSTVESPQSPGQIYDTRSSFSGRSLAEVVSGSVGKSIHQTDAWLSSVRDWKNYLESLADACRTSLIETYKNNERDATPEQVEALFTNKRFRKEAVQRMRNASVTRVMSADPQFFPKYEMRFYDYERIKQELNEIRQLLQTGESGISPDRTIKEFAISQRGDAILEFANNAPGCNHSDPALRFRVSSYMLAETSPIFARMFAGHSSSLHLYDDDDISTLLPLAPTKYFCKDGSEAKLYRMPQVELNHLGSLEILLHAAHMHNEMVPREIEFEQFVAIAESCMRYKSTSPLELIVEHRWLPQWMHKGADDMPDGLLVISYAFGLRRLFSRMSKTTILNLVDEKELLAKPWPQKIKDKIWAVRCAKMAQIHECCVSTIREYMREPTHNTLEGSEELSLDTRASFSSDSLPPTMLTSTPRCPKGSHWCDATNLGWLMLLYNEMNLLPHIMAPDVLSHLPRAQPQSKSLAQIVDALRRIPAPPTPVHRGVCDPGPMFRSAISDIYNSVLGLTLFDISGKSHGWGLSKHREREPQTQLNKGLDRMAAPDPNYSVATEFPEIVRLRILCQLDEIDDLHTAAMINRAYYETYKKHELYLMRNILRMDRKRTATRSHIPIGPNTNEEKVLRDESEVLKRTPADTADGITLHSVVETEGDYTDSDSDSDSLYSTSVTPSLPRSAATTSTTTRGRDYQGSSDPARITDSPARTPRARTGTPTSRSTGIGSPTTPRQALFDPPPPPTTAPPITTIDEPPLTVEEANRILWPEDAIRASESPLPISPTCIEGIREKFRAGDPAFDAGLEEKTLVPTGEKQLRSEHDRQVGLLKGGDASHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLE4</accession>
    <name>S0DLE4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425321.1">
        <property type="nucleotide sequence ID" value="XM_023573632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLE4"/>
    <dbReference type="STRING" id="1279085.S0DLE4"/>
    <dbReference type="GeneID" id="35393619"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00134"/>
    <dbReference type="HOGENOM" id="CLU_025521_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="2">
        <location>
            <begin position="10"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="600" mass="67909" checksum="F4A2B72D4BABBFAE" modified="2013-09-18" version="1">MNTSDTLIDCCKNWPKYPRHLLQPCHRRSVLDDYRVRLDKPKRPLFDASQEKIHFLEPQGSVYGCKETTIASPADLEKHLGQNSEDPHYCMIFIQSKNSRSPLNCSHHSFCYLSTFYQIPASFLDHLFSFGQNPEPLDYHMTGFNGSDTLDSPKSDIVEIPKLGRSGLEHVMQYLLRSVEWDVKHSAWKIRQMAVHHKYDLITGKAFWLNIKANSIMQDRLKESIAHDLKFNPTLAKGLASSFAATLMTHLVHIEWCDESWRQCINDLEEKIRAVLQKAKTASVGQQPDLPAAVKALTSRNDTTAFGAPEKPTPPSPACFNPYEAIGKPLTSYLQSALGKPSPKAHATPLLPLAHKTAAAPVSETDDNLAKRLKSLKALEAFSVEDLQLLHYLGEQLENFRLVMLLNRQTLRDISEHYQDLTARDNFPPAQKAECVRSVASFVRRVERVRKNLEIRVTQIESLRAWLQEGKTLLEGILQYRSVQVSHIFTESSHSQSAKMERIAYKTEQETISMHVITCVTLAFLPGTFVAAFFQSGLIDVNQAASDVQGAVSFHPGAFKLFAAICFPLMFLTFVLWVVLFKFLASRARKRVMEDNVQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLT6</accession>
    <name>S0DLT6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to transcription factor ZMS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_02018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423584.1">
        <property type="nucleotide sequence ID" value="XM_023579339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLT6"/>
    <dbReference type="STRING" id="1279085.S0DLT6"/>
    <dbReference type="GeneID" id="35395501"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02018"/>
    <dbReference type="HOGENOM" id="CLU_003864_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="292"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT61503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="842" mass="94669" checksum="96BEBF4D9DB9B0B8" modified="2013-09-18" version="1">MLSASEEQGSGGAKTTSTVQSPATVATPRAALDWLETSTSQQNMTSAVQVQTNLTQSDQITSNDGQSSSVESHLRREPERPTNIVGDIPDTYSLPTNWLPFDDVPLNSAFLPSLNDIPRIASEVGDASTTAPQSLETQPSFPILPEIHEQSLQQDHVSALIASMASNKQRKTQFSDTNDDPALPGTKATHYSDGAGFRESRAERYMRQRRAAYVEEHGPSPGQQVHVSWISDLDARVAAASKRIGASSDVPDSIFEELMSKLDSHATRSHIFADFAAHKENLLTKRTFQLFISLYFEHFHPVNPFVDRSHLSIPLWGWSLCLATAAIGSKYFGSEEVNRFGDCLCCILHELMARELDFIGSQEPLPYIQARILASVGLCQSRQPELLRCGYNGLAMAAQACLRLRLLSEDDNIGSYQNDQSLEQKWITWRFRETRRRTGLFVWLASGYFALASEHHPCLFPDQPQLRLPCREELWAAKSPEAWSTANLADRDADPITFSTEEASRSTVPEVTLELWRHLKSQNSSDSFATIVIIHMLVHRRWAANGYLADALRDIPQTNQLTIHVPERKYLGSVPEYIKWRNQCCDCLDVLHWEALSLSAKAEGLEDPVLLHLHLARLSLLAPVQDLFAFADQSTLSGITHMTPSNLYRHGTASSEPRQTIKIWATQDRYKARLAVIHAGAVLWHVRRYSSDSIIEPFALFLASLVLWAYGQTSNIRRLYESAYTAAQSPLSDNEDSVTSAPTTHGSLESHTMRDCMSTRRRMPSAMQLDRPMDDELVQYFIRFGEDLRLPLEGVDDLCATEGPLHMLQEVSSLLMEQHKPWDISETYARFLRDLKMSQWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMY9</accession>
    <name>S0DMY9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">FFUJ_05033</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425887.1">
        <property type="nucleotide sequence ID" value="XM_023571610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMY9"/>
    <dbReference type="STRING" id="1279085.S0DMY9"/>
    <dbReference type="GeneID" id="35398514"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05033"/>
    <dbReference type="HOGENOM" id="CLU_030988_10_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990305">
        <property type="term" value="C:RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990303">
        <property type="term" value="C:UBR1-RAD6 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034620">
        <property type="term" value="P:cellular response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042275">
        <property type="term" value="P:error-free postreplication DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000639">
        <property type="term" value="P:negative regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090089">
        <property type="term" value="P:regulation of dipeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120174">
        <property type="term" value="P:stress-induced homeostatically regulated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="23" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="22">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCT63806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="151" mass="17199" checksum="656AE4A4FB03C8DE" modified="2013-09-18" version="1">MSTAARRRLMRDFKRMQTDPPAGVSASPVPDNVMTWNAVIIGPADTPFEDGTFRLVMQFEEQYPNKPPQVKFISQMFHPNVYATGELCLDILQNRWSPTYDVAAVLTSIQSLLNDPNTGSPANVEASNLYKDNRKEYTKRVRETVEKSWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNC8</accession>
    <name>S0DNC8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_00485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424993.1">
        <property type="nucleotide sequence ID" value="XM_023573241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNC8"/>
    <dbReference type="STRING" id="1279085.S0DNC8"/>
    <dbReference type="GeneID" id="35393970"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00485"/>
    <dbReference type="HOGENOM" id="CLU_012767_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000083">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054551">
        <property type="entry name" value="RSC4_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22994">
        <property type="entry name" value="RSC4_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="58"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="284"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="388"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT62912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="678" mass="75208" checksum="651DE2B9A3D52120" modified="2013-09-18" version="1">MDSKRKANGAAAVDNDDRGSKRRRLTGDFDLSKGESRESTTTYGLSFLEHIRKTADKAGRLVATNFEELPSREENADYYEQTRMPISLSMIEQKLNDGEFENLSELEGYFKRMISNAKEFYPRGTEIYEDAERLRKAVSNYMTKKNPAYHVRGYQAVPTPFPDDDDEEANEDNEDEEMNDNEDEDEDEPEEEKDDEDEEDEEEEEAPSSRRRTITLKRRTPGRTPGRRASTRGKETPKPAASAAKPDHVYEDVPYKGLSFQQAQEKLIEELIRREDPGYDGPYFEAFINLPPRSLKEYFKVISDPMSIRKLQKAVKGFHGRGGSTGVSDFKSWAAFEEKAKLLWTNAYFYNEEGSEIYLVAQDLEKFFYDQLKQAQAVVTEPSQPKIKLKVGGSSETPTPGPKKITIHVGGQRDSADSPAPVQSKGALTNGQTVNGTARTSTPAQAVNPQLEKARSTSLSAVPSPSPSVHSALKPEEASGASPAVPSQPPSAAPSQATPSVPAAAPVAVPAPVPVPPPQPITNPLVNGYMDQKHPRRPGKGIDDALIESMKIQVHPTLQSHSPVLATIRPNPKEMEQSATLNLPPHLTRILAVTAIPSHLQTRQYSLWTLVNKQPLKPIHHQAPGQRPHERAFEAMLHPGLNVLESHLIAAIPRDERVPGGPEVELEVFTISINVLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNN8</accession>
    <name>S0DNN8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">biotin synthase</fullName>
            <ecNumber evidence="4">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_00380</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425093.1">
        <property type="nucleotide sequence ID" value="XM_023573358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DNN8"/>
    <dbReference type="GeneID" id="35393865"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00380"/>
    <dbReference type="HOGENOM" id="CLU_033172_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="16">
        <location>
            <begin position="115"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT63012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="410" mass="45124" checksum="A98A49A0B82DAE6F" modified="2013-09-18" version="1">MKPGASLRLRALRQVTPSNRLSLPASARWQHSRAMSTVVDFPPRPSQPPPPPAGANEAIEKQRAEKRKQILREAVTATQVRHDWTKEEIAAIYYQPALELAYQASTVHRRWHNPAEVQLCTLMNIKTGGCTEDCSYCAQSTRYQEGTKVPAKRVESVESVLAAARTAKEKGSTRFXXXXXXXXXXXXXXXLKNIKAMVEGVKGMGMEVCVTLGMIDAEQAKELKAAGLTAYNHNVDTSREFYPSVITTRSYDERLQTLSHVRDAGIKVCSGGILGLGETSEDRVGLLHTVSTLPSHPESFPVNALVPIKGTPLGDRPMVEFTSMLRTIATARIIMPSTIIRIAAGRKTMSEEKQALCFMAGANAIFTGEKMLTTECNGWDEDAAMFGRWGLEPMKSFDKSPQPAPEVRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNZ4</accession>
    <name>S0DNZ4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable G protein alpha subunit GNA-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_04487</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426385.1">
        <property type="nucleotide sequence ID" value="XM_023572222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNZ4"/>
    <dbReference type="STRING" id="1279085.S0DNZ4"/>
    <dbReference type="GeneID" id="35397968"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04487"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT64304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="355" mass="40744" checksum="606DA7EAFE1045A4" modified="2013-09-18" version="1">MGACMSSSNEEADQKKKSQAIDKILEEDSKRLRKECKILLLGSGESGKSTIVKQMKIIHLKGYSEDELFNYRPTVFKNLVECAKAVIMAMQQFDIEPQNEENKAHAEFLLEYQAESGPQAQIDSKVGAAVQALWNDPAKDLLMEHQTEFYLMDSAEYFFQEAMRIVSSDYLPNEMDVLRARTKTTGIYETRFQMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEESSQNRMMESLLLFDSVVNSRWFMRTSIILFLNKVDIFKQKLSRSPLGNYFPDYSGGNDVNKAAKYLLWRFNQVNRAHLNLYPHLTQATDTSNIRLVFAAVKETILNNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ58</accession>
    <name>S0DQ58_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to mitochondrial genome maintenance protein Mgr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426656.1">
        <property type="nucleotide sequence ID" value="XM_023572553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ58"/>
    <dbReference type="STRING" id="1279085.S0DQ58"/>
    <dbReference type="GeneID" id="35397673"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04192"/>
    <dbReference type="HOGENOM" id="CLU_142435_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT64575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="109" mass="11769" checksum="A5573010E18EF08D" modified="2013-09-18" version="1">MPPVAPINAGQHGPSNVDKLKMGAMMGGTVGVIMGFVFGTVNIFRYGAGPNGIMRTLGQYMLGSGATFGFFMSIGSVIRSDADPKLHEMYMRAQRRPIMLMANPAWRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQN3</accession>
    <name>S0DQN3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase 4 core regulatory subunit R2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424939.1">
        <property type="nucleotide sequence ID" value="XM_023573174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQN3"/>
    <dbReference type="STRING" id="1279085.S0DQN3"/>
    <dbReference type="GeneID" id="35394030"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00545"/>
    <dbReference type="HOGENOM" id="CLU_024587_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="49299" checksum="BD080349175B6703" modified="2013-09-18" version="1">MEVDSDNGPLTLFATGAAVEKDVWPAVRSDIIARLDKIAHNEFPIPKLPPPPPAHQPPVEVRASAPSSPQAESSQETNKETSATESLPATQVIDGALPKQLADMVIDIRKHLETFETHPPHTIQRLAELILRPRAHYRAVAAYLHAVDRVVQVTSSTKTYPLPPPIPDMSSMHLNGEDPKDPAVSVSWSNPTTAALGTDEALGGALLTPIPWLTRRSPESSQDTPGAQIHSESTETIEGPNGVGSIETVSVSVNGIPSTGHARGVTQGELLRQEQRAGVVPVSQLSRAQEVVLEGERMTMDDEEDEEPREEEDEIPHARGPEEIGMSDTGPQSTTTSFMSEGSMGMQGIDVEAAVGRKHDDDEEGKVDVDADGDAEGESEPKSPGAESVGSKREADEDLQSETHKKLKEEEEEDKAEDDKKADTAASDVKEEEKKGEEAKAPASQTKSEADDNKMDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQU6</accession>
    <name>S0DQU6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_05055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425868.1">
        <property type="nucleotide sequence ID" value="XM_023571586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQU6"/>
    <dbReference type="STRING" id="1279085.S0DQU6"/>
    <dbReference type="GeneID" id="35398536"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05055"/>
    <dbReference type="HOGENOM" id="CLU_015887_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="327"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="527"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT63787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="766" mass="88139" checksum="F0706A03E794E39B" modified="2013-09-18" version="1">MRLGYDRDVADGEARLPLVRRRPLRPESHDWYGPSDVVPYNQYPMPHRTRIDELQRPNGRTPRGYSRSMSLDAYPPTMPMPPAHLMRASTDVYKKRPQFSVYEADEDDDDDERWPAMKPRGRHPEPARPRQVVRRRREPTPESTPPTDSESESESESEESDDENQIEVVVEEPEDKHRRHHRRHRRSPSPDDYLSSPDEKRTPRRRNRIPSPSTSDERDIRYRQASSERGSPDRRPALRREISDTPRYSLPTRFNSVLGASRPPVASRRTAKVVESRELVREGRPRRLPIATIETVEVSRESSRRPPSIARSGFDSSRNSSPDRPRLIRDCKGCLDEVPVSKCPKLDCGHRMCHSCLKRRFKQSMTEAEHMPPTCCTDAHIGLEHVDKLFDSTFKRIWNKKFVEYSLRNRLYCPSRRCGEWIRPADIYRDRETGRKAARCDQCNTKVCVACNGRWHFASKCPRDEETASFLDYVRVEGRKRCYRCGASAQLREGDNHALCRCGAEFCLVCGEKPKRCECPWFDPDAPESDHEPEVTHRGEIQVFREDSTEEDSRVARRPRKSKPTRPPIYDEEAIMRQQQEERDDELVRRSHYHGKDYEYDIGGAPEVPRSSDPYSGDSPRRVGRRVVGGAPPSPKDFERGTPRSGGYYGGRMDRRHAEDRYAPDSPGMRPPPMGMPPPVIEEGYRGGVGPLIVERDPNTYDDDDSYYSHSSRSRKGTRRSENRRSSELAGLGPRTPGTNRIDVWRTFVEPGDPEGEIAAAAAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQX2</accession>
    <name>S0DQX2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable kinesin-related protein KIP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426931.1">
        <property type="nucleotide sequence ID" value="XM_023572887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQX2"/>
    <dbReference type="STRING" id="1279085.S0DQX2"/>
    <dbReference type="GeneID" id="35397372"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03891"/>
    <dbReference type="HOGENOM" id="CLU_001485_21_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000053">
        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="14"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="830"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="898"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="767"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="907"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="140"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1030" mass="112512" checksum="ACD81DF885D1A0BF" modified="2013-09-18" version="1">MAVMGASAAAGQNSITVAVRVRPFTIREAAQLQKNDDGTLFLGDGSLAAAPTPKLHQRGIRNVIKVVDDRCLVFDPPEDSPVQKFSRSVLPSSKKVKDQVFAFDRVFDENTTQSDVYEGTTRTLLDSVLDGYNATVFAYGATGCGKTHTITGTSQHPGIIFMTMQELFEKIEERSQDKVTDLSLSYLEIYNETIRDLLVPGGSRGGLMLREDSNQAVTVSGLTSHHPKDVQEVMDMIVQGNEYRTVSPTEANATSSRSHAVLQINIAQKDRSAGASEPHTMATLSIIDLAGSERASVTKNRGERLTEGANINKSLLALGSCINALCDRRQKQHVPYRNSKLTRLLKFSLGGNCKTVMIVCVSPSSAHFDETQNTLRYANRAKNIQTKVTRNVFNVNRHVKDFLVKIDEQMALINELKAQQKDAEAMFFAKFRKQCDKRDAMAREGIQRLRIAYENSAPERQERITNMKRLKAFERRIGMLSGWIAAFDTVCDERGDEDAMPENLVAIRKTAQGILVELENSRHHIHQKLEKSAWDRAIDTALSHSLQQLQGIEGADNGEADNLTREAELIKANFNREAYREVLEQDKAGDAAMIQMLLTAQFDILASLSDTLGMGEEDAVAHAKEMINRLLQTGFTAAGQVVKPDGSMPVIEVFSPSKRGTPKRKKAIAMHIKPVSAPNFMPAHSDHAPVSPIKGSPRRRKVLGASKKGVSFTPVKAKKKGGVRWRDDETEEGTLEDFSKTPQKYNSSPAIPSPEKPIVAPIMPSYLEPETSTVEESSPSLEIPEASSLGAKPSRFQAGFLSKGPRHSLADGSPKAPTMTLKLEASPDIQRTPPLRSLDVTKSGNFSPSPSGLGIPRAIRRLPTIHDENNPPGSGSDSETSTIDARKLQTALRTAMKEKARRASIMAGTTASSTKRVSSMGSLPERTGPRPSLPAALASSTNGISRLRRGSAERRRSPPMACSPNDFKIDMALTPGQARRMNMNNTATRMEGPGSSPQGGMAGSAPRRITIGMGSGAAHRRQDSRGYTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR95</accession>
    <name>S0DR95_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426018.1">
        <property type="nucleotide sequence ID" value="XM_023571769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR95"/>
    <dbReference type="GeneID" id="35398372"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04891"/>
    <dbReference type="HOGENOM" id="CLU_005396_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055528">
        <property type="entry name" value="DUF7102"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057559">
        <property type="entry name" value="SAM_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23394">
        <property type="entry name" value="DUF7102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23395">
        <property type="entry name" value="SAM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7102" evidence="1">
        <location>
            <begin position="625"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-like" evidence="2">
        <location>
            <begin position="802"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT63937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="871" mass="96408" checksum="40C1A305749C7221" modified="2013-09-18" version="1">MSSTTASTAISREVTDYAIENQCFHNHHGAPYRFRDIVKQLRETAEPAKANGLIDQPGLTAAPLPLTKITLKPFLDDESCEIPIDPKVPASSVFRFLGQTKSLRLPSESIDTGHDLQKELSQYRQDIQIASSCNILTQWLPLSYVSVEKDEGLGFPSTISRWQTLALRELEGDEPSFTESDHDSLYTQQTPNQACTPDQIRQIFSLDKHYRSKLEPVSPPLSPASDLGEPFLPSREHMVIDLTSEPSSPSNPVVEDLDWNMQHGFVDSQPPAPSTMPSSPPTAKAAFLSNKAKKHSALKLDTPILPSSTVTSPVQGNLAETLPPHFLHPNEAPQPPTEDGGYFEEALQSILDEKHHQANQRLEQDRLNPVDTLFRLRVPAVDFQTPNTEWLSHFSTSRGHFEWLQHSLPRDFHLTCYKDLSRLEASLKWTPIPHESGQVSLTEAAIQLGPAAREMLTLRRPQLCSRNYVVSRNLLIVLQILNDEEIEQEVASVMASSPLICHGNQDSSTAISQSQKPHVAPSLKELIGSLRKGTGNKSVCERENLLLEATDLSASSSLLSGFMQLRQPKRLKKGSGSSQTSVASRAMPSMADPTTLPIIHEEAQSELQDAPVPNVEIPQEACRYIVSLDLSRSTLSYLEKVWPQAELIDRDFSQYNTVAWSPGLAQRRETISSLAFEADISMSPGAGLILTTILKVKQKPLPGSSALTPFRERVRRVSEKYESLFVLVSESNPLGEYVGSPTPSDISGYADFVRFTTSLGAGISTHLVSGCDETLSKWALSIMSRYSTSAHQFGPFLDFRDGAWELFLRRAGLNISAAQIIAGLLVCEYGQGGLASFLSMRAEERVSKYGQIMGGRRILNNVSRILDREWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRR0</accession>
    <name>S0DRR0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_00121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425334.1">
        <property type="nucleotide sequence ID" value="XM_023573646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRR0"/>
    <dbReference type="STRING" id="1279085.S0DRR0"/>
    <dbReference type="GeneID" id="35393606"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00121"/>
    <dbReference type="HOGENOM" id="CLU_011409_12_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT63253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="417" mass="48338" checksum="8C2778E54A47F81A" modified="2013-09-18" version="1">MRQAHCKVKTGCLTCKIRRVKCDEKKPACHRCTSTGRKCDGYALMQKINPRDVAHGRMLLPRVSTIDPQALLPVEERRALGYFHSVISPRLSSARDGYFWTHLVMQLSESEAVVKHTILSISSLFESSEGKSVAPYTERFALQHYTKAIQRLKTVHSEPLVLLVCILFICVEYLLANNKIALQHCQHGLAIMEKCSNPWARRYLMPVFRRMTAVPMLFGPEDIESESMPALIYMIPTKFYCMEDAQYMMDDIFNRVVRLCHMRHRGVVFDMTEEYDTISTHLQTWQTLYEKLEVDTTSLLYQAQERSLFMRLKLSYLELSADFRYEEHMGTFRQVLQLASWQSERSTKQSSFELAYTPMLFFTIMKCPDLSIRLPALRLMKKLGSPTEGICENLQMLTTSREIIQQEHGVEIVDIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSF8</accession>
    <name>S0DSF8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_04464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426408.1">
        <property type="nucleotide sequence ID" value="XM_023572247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSF8"/>
    <dbReference type="STRING" id="1279085.S0DSF8"/>
    <dbReference type="GeneID" id="35397945"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04464"/>
    <dbReference type="HOGENOM" id="CLU_004083_5_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF45">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="660"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT64327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="788" mass="87456" checksum="28BD73BDED10E536" modified="2013-09-18" version="1">MPYPNGIPGVPGSAPQQQQQSQVQQPQDPSAIKLTRGTSCVLCQQRKVRCDKNKPCANCVKAKVECRVIPPQPPRRRKKRLQEKDLIDRLKKYETLLAEHGVKVEAIGHELRPDGPPGEDVEELENDFEGLKTTPEASSSPAPSNSEQRTGGGAWFSYHKEFRASEHMLQDSSDDEPEVGSSIHRAFDRMFDTDGFPFIVGAAPVPIANLHPSTIHIFQLWQIYIDNINPLLKITHVPTVQAQIIEASSDLENAPKNIEALMFSMYLMAITSLEDADVYKRFNETKKELLARYHTGTQHALTKAGFMRVNDPILLQAYILYLFAVRWFVDPRQVFCLIGLAVRIAQRMGLHRDPAQFGLPPFEVEQRRRLWWTLVGYDRRLGEMAGSTVTALSTGGDCKIPMNVNDSDLHVDGKELPTPHSGPTEMLFSLTRVELAMAVSSDSNRDSYKMNNTDKSPVGTPASKNQATIRLAGQDGPAYTLDGFCAHIEGTYLSQCDPKIPLHFFTLTMTRQAMCKMRIISFLVRMHSNDDNLPLKDVERDSLFLQATQMIEYDNVVQSSESLRPFKWYSMHHFPFPAYMFLVQELRHRVSGPMVERAWDAIEKNHDLRGLLNNYHNPMHMAFGGHFIKAWDAHEAALVAAGRQVHRPAFLGPLRERVAARRRAKQANRPVPNPPQPPVGVPHSQVTTPSSTGFASSVGHMTPGTVHHGQRANSGSVASSDEPGEMDWTYMMSGYNDTSSFTPMGGFGSFSGGFGGGMPGMPGIPPGMGGMGHPPTGNPPGGRMYGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSN9</accession>
    <name>S0DSN9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to multidrug resistant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_02397</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427536.1">
        <property type="nucleotide sequence ID" value="XM_023574122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSN9"/>
    <dbReference type="STRING" id="1279085.S0DSN9"/>
    <dbReference type="GeneID" id="35395879"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02397"/>
    <dbReference type="HOGENOM" id="CLU_008455_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="124"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT65455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="570" mass="62496" checksum="3C0458FFD661A0B9" modified="2013-09-18" version="1">MSRDDDLTREESKSHALTREPTREEKTREAIAEGHDADIPSNIGFIPTPADEQRRASLTSHRRASHARERASLDPEKHGKENESVRDEEEGGSQTQSESDIVWWDGDKDRQNPYNFATWKKVLNCVLVSALTFVTPLASSMFAPGVPQLMVEFGSQSRELASFCVSVYVLGFAAGPMIFAPLSELYGRQVVYHCCNVGFIVFVVACAKAPSLSSFIAFRFLSGTFGSTPITNGGGTIADMIVQEKRGAAMASFSIGPLLGPIIGPVVGGVITDALGWRWVFWIIAIISGVLSSIFFFASEETYAPVILARKTKRLQKETGNDRLRSKLDAGLSPADYFKRGILRPFKMLLFSPICIICGVYVGLAYAYLYLLFTSLTPLFMKIYHFNTVHAGLTFLGLGVGSMIGVAYFSVSSDKYMKKKAAAAKEQGIDDPAESMRPENRLPPLRIGAVLLPAGFFIYGWTAEYQTHWIAPILGTCVIGVGNLVIFMSLQMYLIDSFTVYAASALAANAVMRSIAGAFLPLAGLPMYDKLGMGWGNSLLGFIAAALIPAPWLFIKYGEHLRKKFEIKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSP8</accession>
    <name>S0DSP8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="11" type="ORF">FFUJ_02529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSP8"/>
    <dbReference type="STRING" id="1279085.S0DSP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02529"/>
    <dbReference type="HOGENOM" id="CLU_004096_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT65574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="979" mass="109211" checksum="5DEB7E128A870C2B" modified="2013-09-18" version="1">MDSRAAAAEAMRSAIEYWSQFVARSISQRLDTEKFENYVRLVHDQHPLPPALVADFFLRPQPSNDNSLDPRIPPYLQVLTRLGYVDAPSILKALYKYSSLHAYAQQPNAHEGRENEKENGKSDDKEKDENQQKITRWKSSYWAEEVLFYGITKSVVEGKAIRDSKTALDMTRIISKLMVLFTTAFAADMIEQLHTAQVRDEMESSRAALVALLLRMCENDILVGALVPQITDKLEQFRTEILACSDPADKKKQATNAAMDELLDSAVGLDNFVVADIPVSNTRAGLYIYLNAALIARPLLDDHALFSYMSNKYQGDIQSSAIDLILASFDILANAVFRNEGQKDAHLLRSFLINKIPILLYQLLPPGFPGTSAEFCITEALSHVDTSLFPTASLMFDESRNNNPYTESIREEFCAACVLHGLVQREHVERILGEISLSYEPSLQKHSKDKLVQDCLSDTEKIQGLVRELDKMDGNVGAVCQALVEVLRQSCHNKETMSLKVLCSQLAAKPQSLDVILLFEKLPNILEPLCQLLDNWRYEDDQEEYQPVYEEFGAVLLLVLAFTYRYNLNAVDIGIASPDSWVAKIIGRGHIGRQCNELTQRENDHLNGWIHGLFDTEAGGLGDELMSSCPPQEFYLVVAPLFQSIVVAYTHGYLNDESLKGGIEYYLWIDQKEQKSIIKILQLILLPSSISGEASTMLSSVKNLIAKPLEHALRTYQRRDPQNQDIEPLLRTLRDSIPLSRRTGGTDLNELESWTVTPPTGLSSAIKLTTQGLVHWSMHPAMNSMPTSYTHRQILAALKIMGPKRVLHVILEEIRQHTETGSASIVYDVAISLICAPDAAKDAPAVVDANGNMLPSVQRQRSLRDLLKVEAEGCRKLQKKDPALAEIVVRLHRRVEAQMIIPQPPGMLQTAEMSLNLDGDTAALGDAMAAAASGVQDNMSVDNLTLDVSMDPSGDAAMFEGFDTQDMDNFDWDDIGNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DT84</accession>
    <name>S0DT84_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_02767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endosome</location>
            <location evidence="4">Multivesicular body membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 4">Prevacuolar compartment membrane</location>
            <topology evidence="1 4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427875.1">
        <property type="nucleotide sequence ID" value="XM_023574537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DT84"/>
    <dbReference type="STRING" id="1279085.S0DT84"/>
    <dbReference type="GeneID" id="35396249"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02767"/>
    <dbReference type="HOGENOM" id="CLU_014574_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="6">
        <location>
            <begin position="181"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="7">
        <location>
            <begin position="343"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="8">
        <location>
            <begin position="491"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT65794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="601" mass="65895" checksum="D33EEF8A2B2309A6" modified="2013-09-18" version="1">MESDKMSQKPASPTNEDYRPPLPPRPSTSATDTASLQAHATTAITPVEIQTLSFPDGSRGTFSTPGPDSLPSPAEGDHASPNRQESSGSGEADDAASIMSFAPTMRPAGDIASLLAGELHKKSPAWKMLRTQSATVLPFEKGRVGAYDRFAEFHHEFNSLPEDYGEDVESDILHLWKSKLKHYLILSSAGKPIWSRYGDLSLINSSMGVVQTIISFYEGAMNPLQAFSAGDTRFVVLTKGPLYFVAISKLGESDSQIQAQLDALYMQILSTLTLPRLTHIFANRPSTDLRKPLEGTEGLLSSLADTFTKGSASALLGSLECLRLRKSQRHAINNTFLKLRTDKLLYGLIVAGGKLVSVIRPRRHSLHPSDLQLIFNMLFESDGIKGGGGENWIPICLPAFNNKGYLYMYVSFFDGTSGDQASSPAAAQGRSSEEEIAMILVSTDRESFFELKQMRDNVAQQLAKNGTLAIIQNATRLGRPKIHEIAPGSQVSHFLYKSRANVQFCMASLEPHFTGLVERRRLMTVYHELHASIHAKHSHLKVLHAVGDDATSLAWTTPVFEFYCVAGPNVSRATITQGANKIIQWAKREEERLFIIGGGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU71</accession>
    <name>S0DU71_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_03123</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428205.1">
        <property type="nucleotide sequence ID" value="XM_023574935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU71"/>
    <dbReference type="STRING" id="1279085.S0DU71"/>
    <dbReference type="GeneID" id="35396605"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03123"/>
    <dbReference type="HOGENOM" id="CLU_016922_12_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT66124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="459" mass="51057" checksum="38EAD683F5ED95C7" modified="2013-09-18" version="1">MPSFVESPVRTEIPGPVSKASSKRLDAIFDARAVHFVVDYDKSHDNYIVDVDGNKYLDVYAQIASIPVGYNNDTLIEAAKSPEMISALVNRPAIGNFPSDQWVDILRNGLMKVAPKGLSYIFTAQSGSEANELAYKAAFMLYSRRKRGNADWNEEEINSCLENSKPGSPELAIMSFKNSFHGRGFGSLSTTRSKAVHKLDIPSFNWPQAPFPALKYPLEEHAEENAAEEKRCLEEVERIMTTWHCPVAGLIVEPIQSEGGDNHASPAFFQGLRDITKKHGSVLIADEVQTGFGATGSFWGHDHWNLTSPPDMVTFSKKAQTAGYFFGNEMLIPDKAYRQFNTWIGDPARVIMCKAVIQEILDKKLVEQTARVGTHLYAELARLAAKYPEHIQNLRGKDQGTFIAFDTKDPAGLVRSMRHIGVNIGTCGKNTVRLRPMLIFQEEHIPILINAFDKVIGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU98</accession>
    <name>S0DU98_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428096.1">
        <property type="nucleotide sequence ID" value="XM_023574806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU98"/>
    <dbReference type="STRING" id="1279085.S0DU98"/>
    <dbReference type="GeneID" id="35396490"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03008"/>
    <dbReference type="HOGENOM" id="CLU_072876_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484540" description="MICOS complex subunit" evidence="3">
        <location>
            <begin position="33"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="249" mass="27022" checksum="B7BEDC91822067D3" modified="2013-09-18" version="1">MASRVVFSRRSLAPLAAMALGGMALAPATVFAEGPSDFKRKPIYDDYDIPTANPAPVTPPPVAATPVEPVDDEERHHSPTPTERLAVHIGRGRLALYKYAVAAENKVNETMDSAFNLEQSFTSTIASLAPSRESGEQLMPGAIYVLVAAMAGSIITRNRSIILRASLPLALGIGAGWTVLPVTMRNISDLTWKYEQRFPVIAESHIRLRESIVNSVSFAKAHSQVGVRYVDEKVTDAREAVEGWVQKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVI8</accession>
    <name>S0DVI8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable TfdA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_03531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428577.1">
        <property type="nucleotide sequence ID" value="XM_023575389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVI8"/>
    <dbReference type="STRING" id="1279085.S0DVI8"/>
    <dbReference type="GeneID" id="35397013"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03531"/>
    <dbReference type="HOGENOM" id="CLU_041041_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000011">
        <property type="entry name" value="Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="97"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT66496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="407" mass="45893" checksum="5D128D3DCBC468E7" modified="2013-09-18" version="1">MSFTTTVTAAPPPGQPDIAYAPNYENYQARTTKRLKEGKLPTSVPDGFPEQLTGDLVWEGDSVGQTYDWTYKLSEDQLSEIDQALQHFKGLGLPFGHISAETFPLPKLHSELRKLSDELHKGHGFFVIRGVNVDNYTREENAIIYVGISSHIASQRGRQDNKFNGKPADVVLTHVKDLSAGQDKSAIGSPAYTTDRQVFHTDSGDIVSLFCLETALEGGASRIASTWRVYNELARTRPDLVHTLSQNWDVENFANPNKKFTSRPLLYHHKATYTLPERVVLQYARRYFVGFGALPRSHDIPPITEAQAEALDALHFLGDKLSVSTNFAKGDMQFINNLAVFHARDAFTDSPTQQRHLLRLWLRDPENAWETPEPLRERWAELYEGVTPDAQVFPLEPYIRSASNRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVX0</accession>
    <name>S0DVX0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 16">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FFUJ_02475</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 16"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427608.1">
        <property type="nucleotide sequence ID" value="XM_023574209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVX0"/>
    <dbReference type="STRING" id="1279085.S0DVX0"/>
    <dbReference type="GeneID" id="35395957"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02475"/>
    <dbReference type="HOGENOM" id="CLU_004391_0_0_1"/>
    <dbReference type="PHI-base" id="PHI:8299"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20072">
        <property type="entry name" value="SET_SET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="1112"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="1238"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="118"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="401"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="544"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="730"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="833"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="878"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCT65527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1254" mass="139516" checksum="38033DCEB225E739" modified="2013-09-18" version="1">MTRPPGASFAQFFPTAPKVKAQSQTRPDLSRDREQSKSGSTPASLTGACDPTPTSAASDAAANAGQNGTVSSSDTMPAQPEDTESPFTDIPSTVDSASSYSSTASSIFSTTARHGAAATSASSRIPTSSLTPIASKDSPNSLASATTKPDMSTCLTADRAARQSSRNSPAVGFNGSISDGLLSNERIPARDPMPSVKGLKCTYDPLLDRVHNKSVSKSAKPTYKEFGRDDDAPPTDPRLAKSDGRLGYINTDYYLPKSRLRTAPENIKPYPYDSKTSIGPGPPTQIVVTRYNPLVPFSKVTAIFATFGEIAESSNKMHPETGSYLGFATIRYRDSKRPDRPPVSAMEAARRAVRTRGIKVDADIVRVEYDAEGRRSRRMLEEHLKREKEKFEKKEQERLALAAKAPPTGPKSGTAPVFTRPPPTAPKGPSAQRQPVVPSAPQLSLTPSQQKGLNLETSNLTQKLADDPYIYVTGDSVPVLPSILPHMKKRLKNYGFEEIRVDKSGYFIVFRNSFTGKSEAERCFRAVNHTEFFNYDMTMQLCLPRPHRDGPSSHRRSSASPDRKTNTEPRYRDEKERRRREEEADLEEEKKQRAKNFDPVIEAVEVVRREMTEHLIRHIRTKVAAPALSDFLDPANHAAKRRKLNIEHPDDLQEMVSVEDGNDSSRVGTPNSRADPIEQQTGRIAPKALPRIRKTKVKQKNAFVDPFARKRPPVARNPFRSLHHRLRSLDSDVESDDDTDTRTLLARETEEAESRPRSRMSTDDEASKDDFVPWEQGEDDSMTEASFAIADSAHSRKRKLAESVESAFKRQKKSDEELFGVRLTALGSGFETREGSADVIPEPETGDDIDSRISRSETPVSVVGKSLKKRPARAKKPKVFEELEAQDLRTETDSQRGEEEAVEPPKAKKTGANTEKSTAKEVVTDKYDEKLLSTEPLTPALALPEGTKPDLPLFQGLAIGQSDIPDLSKLSRRFTAKDIGNPELWLWTRNRIRELNSANRTLDSPVTIGGYYVPNSTGCARTEGVKKILNSEKSKYLPHHIKVQKARQELEARNKSGKDAARIAIEKQAATDSERNKRASNRRYVQDLNDQKKTLGQDADIFKFNQLKKRKKPVKFERSAIHNWGLYAMENIAKDDMIIEYVGEQVRQQIAEIRENRYLKSGIGSSYLFRIDDNTVIDATKKGGIARFINHSCDPNCTAKIIKVEGSKRIVIYALKDIATTDELTYDYKFEREIGSLDRIPCLCGTANCKGFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVX8</accession>
    <name>S0DVX8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428805.1">
        <property type="nucleotide sequence ID" value="XM_023574980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVX8"/>
    <dbReference type="STRING" id="1279085.S0DVX8"/>
    <dbReference type="GeneID" id="35396646"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03164"/>
    <dbReference type="HOGENOM" id="CLU_090028_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="33"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT66724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="127" mass="13820" checksum="C62150F9EEE52B1C" modified="2013-09-18" version="1">MGKNDKKGADKGGKGKADKGKDARDSGGKSKGAQSINVRHILCEKHAKKEEALAKLNDGLKFDEVAREYSEDKARQGGSLGWKTKGSLDPKFEEVAFALESSTTASPKFVECKTEFGYHIIMVEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX53</accession>
    <name>S0DX53_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meiotically up-regulated gene 154 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_04457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT65038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427119.1">
        <property type="nucleotide sequence ID" value="XM_023572255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX53"/>
    <dbReference type="STRING" id="1279085.S0DX53"/>
    <dbReference type="GeneID" id="35397938"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04457"/>
    <dbReference type="HOGENOM" id="CLU_044030_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT65038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50987" checksum="182C8358E4E9EB07" modified="2013-09-18" version="1">MPRLVRRQPLRERIMAAINPMDFLLWLSEELETRDWDSASVGTQMGLAMNFVFLLARANSGSSSPSDDIFSDETSSGWLSFLIYPLVWALIAFSFTNAFYTITRTRKYRLFLAKVDRPLSTPSARRVKVNQSSASPSTPLSYLANLITPESAESRAHPDKTSDVWELSVWDPLPVSLRLSCLFGPGHVLVYMIFLPLAPLDPRPSVTVLNTLILQALVSAQLLFFCSRFAQQAKDKAVIQEQVMKEYDTKFVHPRLHPTVRDIGTQFSIDQPDDYQEFVQTGTPTVQIRHGFQVHSNPYTGTDHTPEERSLTPTSNNVMKPHMFTPPTATRRSEAFRPATSQKSTVPRHSLPAGYTSTGTSSGVQGMNFGGNMGIHTHNKSPLKKATSLNELNPQEAASPRNSREMAAYEQRNWGATTPSKKLDSRRLTGSRPNGGGNPFAGLGRQQAPSDNRHPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXS1</accession>
    <name>S0DXS1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable cytokinesis protein SepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429336.1">
        <property type="nucleotide sequence ID" value="XM_023576138.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DXS1"/>
    <dbReference type="GeneID" id="35406905"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13451"/>
    <dbReference type="HOGENOM" id="CLU_001313_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.150:FF:000003">
        <property type="entry name" value="Cytokinesis protein SepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000291">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.30.50:FF:000001">
        <property type="entry name" value="Cytokinesis sepA protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="6">
        <location>
            <begin position="257"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="7">
        <location>
            <begin position="1091"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="5">
        <location>
            <begin position="1531"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="880"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="969"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1231"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1492"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1382"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="923"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1492"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1516"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1556"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1587"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1639"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1677"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1722"/>
            <end position="1731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT67255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1731" mass="194444" checksum="09B48808A440F571" modified="2013-09-18" version="1">MSDKTRQSSGGRSLFSRSKHKDKRLTEESRYPADDAASFRSSRHKRESSAISLDRPESSDGGINQMAGVITSIPYDAVGGGSRSPIPVEYLPKGEQMPVRREPLPHHLNKNGLDFHQYPSWDGTSAQSGAHSPGRQPLGYGYGNVTMASTGRQTQYQQWGPPRGSSSHSNNPPNPRYDSYMSSNARGSADNLSIQSGNTGFIDGRISRSPHVAMPSASSQSSYAASQHSNRDSHRFTKFPSGPPPGQSDPQGGFYFPKPDDDNVVEQMFLQLMQKRGWHNLPEQARRQMMAYPAQKKWTLIYQDRLTEWQGEQKRRQTARPNQYTATPDITTYSDEEGTPEWYVRRVMEDRLDTKGMGSLEVNLRTQQIGWVKRFVECQGQVALMTLLLKINRRTAQGPVQDNTRIDKNLDREYDIIKCVKALMNNKFGADDALIHQKVMVALASSLISPRLTTRKLVSEIITFLCTWGENAEGHLKVIQALDEVKTASGENGRFDAWMRLVEVTIDGRGKMGSLVGASEELRTGGIGMENLLMEYAVATLMLVNMIIDSPERDLELRIHIRAQFTACGIKRILTKMEEFQYELLDKQIERFRTNEAIDYEDMLERENSSIKDDVEGEVKDLTDPVQIADAIQQRLHGTKTNDYFISALQHLMLIRANDGEERLRMFQLVDSMLSYVAMDRRLPNMDLKQSLNFTVQSLLDKLHTDSEARQAQDEALESRQIAEAAMAERDEMKAQLELGADGLVAKLQKQLDEQSRFIDAQRRQADGLKAELDSMQTMRAKEAQRYELETRELYLMLRDAQDVAASKAIKSAAAASSASSKMAGVEDPARMQGILDRERLMERLQMQIERQKTQYKLEGRVWGDAVGPSDRLRALREEMDDRPGTPPGGGTPPRDFTNSVLGSIHRNTKIPRKPLKRRSDGEVIDEDDETEGEDGVIFEKPRIVEMKRPTIDPKQQAGLLGEIGSKVKKFDASDSEDDTTGPSHPSMETSSPITPPGDSDTPKIEVTGAAPPPPPPPPPPPMPGQIPGAPPPPPPPPPPPMPGQIPGAPPPPPPLPGAGGMPPPPPPLPGAMSGHFLARQPAFGAAPSIGLPVVRPKKKLKALHWEKVDAPETSHWAAHTPSAEAREEKYQELSKKGILDEVEKLFMAKEIKKIGIGSSSKKDDKKQIISSDLRKAYEIAFAKFSQYSVEKIVQMIIHCDPEILDNTVVMDFLQKDDLCNIPDNTVKQMAPYSKDWTGPDAKSQDRELDPSELTRQDQLYLYTAFELHHYWKSRMRALALTRSFEQEYEEINEKIRQVVTVSESLRDSVSLMNVLGLILDIGNYMNDANKQARGFKLSSLARLGMVKDDKNESTLADLVERIVRNQYPEWETFADDINGVMTAQKINIEQLQADAKKYIDNIRNIQMSLDSGNLSDPKQFHPQDRVSQIVQRIMKEARRKSEQMELYLEEMMKTYKDIMVFYGEDPADDGARRDFFAKLALFVGEWKKSRDKNMQVEETRKRNEASMKRKHTAQLKLTNANAEAGPTSPSNTGAMDSLLEKLRAAAPQARDQRDRRRRARLKDRHQVRVASGQKIPDLDEIPEVEAGLKNKEEPTEDDSKVLSPGLSSPREGEDDVADRAAALLQGMRGGDGADDNDPERRETLRKARRQTAEEERRLRRRRRERATTNQSEENPDEQKEEPREEPKVEEGEAAKEPPKEEEAPIEDDVPTPRAATTGDSAPEEEQGENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY07</accession>
    <name>S0DY07_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_02278</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427424.1">
        <property type="nucleotide sequence ID" value="XM_023573989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY07"/>
    <dbReference type="STRING" id="1279085.S0DY07"/>
    <dbReference type="GeneID" id="35395760"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02278"/>
    <dbReference type="HOGENOM" id="CLU_041805_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485037" description="Alpha-L-arabinofuranosidase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT65343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="301" mass="32392" checksum="BD919C86E54CD9B6" modified="2013-09-18" version="1">MKYDLSLLSSGLLLLASVGDVAAQCQLPTSYKWTSSGVLAEPKNGWKSLKDFTVAPYNGGQLVYATIFGSSWGSMAFSPVSNLNQLSSASQTGMSSTAVAPTLFYFQPKNIWILAHQWGPTKFSYRTSSNPTNPNGWSAAQPLFTGEIANSDTGPIDQTVIGDSKNMYLFFAGDNGCIYRASMPIGNFPGSFGSASQIVMQDTKANLFEAVQVYSLKGLNNLDGTWTPNAATESNPFAGKANSGATWTNDISHGELIRTSNDQTFPVDPCNLQLLYQGRNPNVGGDYNSLPYRPGLLTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYA5</accession>
    <name>S0DYA5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_13646</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429516.1">
        <property type="nucleotide sequence ID" value="XM_023576355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYA5"/>
    <dbReference type="STRING" id="1279085.S0DYA5"/>
    <dbReference type="GeneID" id="35407100"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13646"/>
    <dbReference type="HOGENOM" id="CLU_011361_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="67"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="210"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT67435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="693" mass="77675" checksum="6E6B8E2573C13613" modified="2013-09-18" version="1">MAPTDRSLSLKSLPMRDASVSGLLAPDGYPQTPSTPRGITPLTSKVTSVLSTTHSDTEFRDALALVDERGIQNDAETRRSVRLDLQKEVIDSNGEVIAEFGRVAEQLRRIKTTIDKLNNGYEDMKSQVVEAHRQTLPALSEASSLLDQKRQVELKQELLGAFKKHFVMSENEVAALTQTAEPVDDRFFNALSKAKKISKDCEILLGFEKQTLGLELMEQTSKNINLGFQKLYKWIQREFKTLNLENPQMNSSIRRALRVLAERPSLFQNCLDFFSEARERILSDSFYVALTGASPSGIEDPSVKPIDMLAHDPLRYVGDMLAWIHSATVSEREALEVLFVAEGEELAKGFKSGRDAEIWRLIAEDDEAEADFNALKALNDLVDRDISGAARVLRQRMEQVIQANEDTIPAYKLANLINFYRITFQKTLGPNSNLVELIGGLETEALRQFRALVRDHIATLQGEFQHAPLDLGPPAFLQDSLKQLKAISKTYDSSLSTSEDRESEFENVLSEAFEPFMSGCENMAKNMNAQNGAIFLINCISSAIACLEPFEFTQHRTKRLRAKSDDAAKGLITSQYQFFRKGSGLDAIFMKLEEDDDKNASLLDEKELAQASQTLDDFLPSALMDAMDNLKHLQDSKLVRQITEEAAEQFCNDFEQLEEVITEGDDESVDSEDDEGLRSVFPRTAAEIRVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ15</accession>
    <name>S0DZ15_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable ABC1 transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_14824</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429877.1">
        <property type="nucleotide sequence ID" value="XM_023576811.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DZ15"/>
    <dbReference type="GeneID" id="35408202"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14824"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1145"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1178"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1222"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1268"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1302"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1422"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="112"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="807"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT67796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1451" mass="162924" checksum="EF54F8E9F0689855" modified="2013-09-18" version="1">MSSGTLGDRTRDNDLSDEPDYEEEIHDLARRFTSQSAASGHGPLFPLSDGGPLDPQSPHFNSKKWAKAYLKTRTEAADGSTPRTAGIAFKNLNAYGFGQATDFQNTLTNIVLKASSFARKLFGDKGQRIDILRHIDGYVESGEMLCVLGPPGSGCSTLLRSIAGETHGFHFGNDTILNYQGIRPEQMKKAYRGEAIYTAEVDHHFPHLTVGDTLYFAARCRCPPKDKLPHGVTAREYAEHLRDVIMAMFGISHTKNTRVGDDYVRGISGGERKRVTIAEAALGYSPLQCWDNSTRGLDSANAVEFCRVLRTQADTIGIASCVAIYQAPQSAYDLFDKVIVLYEGRQIFFGKTDEAQAYFENLGFICPEQQTTADFLTSMTNPVERIVRQGANPPRTSDEFARAWQQSQQRSRLIDEIDYYMEQHPFDGPDLQKFSESRRLDQAAAQRERSPFNLSYLQQYTINLWRGFTMLIGDPSITLTMLISNLFEGLIISSIFYNLPFNTTSFFRRTILLFFIVLINAFASILEIMTLYAKRKVVEKQSRYAFYHPSAEALSAMATDLPYKIVNSILLNCTLYFMCNLRREPGPFFAFLLLSFSITLCMSMMFRLIGSATKSIAQALAPACIILLALVLYSGFAIPPAYMQNWLGWIRWVNPVYYGLQSVFLIEFVGQQFPCSDFVPHGPGYENLGNGEYVCNVPGSVPGQPFVKGEDYLKASFGFVNSHRWRNFGIIIAWTVFFMALHLWTTEYVASERSKGEVLVFLREAIHKVSGKRVNDEEWGLPTPTGKQEASGSSSEKVEVEKQTSVFHWKDVCYDVKIKSETRRILDHVDGWVKPGTLTALMGVSGAGKTTLLDVLASRVTMGVVSGDMLVNGHSRDSSFQRKTGYVTQQDLHQASSTVREALRFSAMLRQPAKYSKQERLNYVETVLSLLGMDAYADAIIGVPGEGLNVEQRKRLTIAVELVARPQLLLFLDEPTSGLDSQTSWSICDLMEQLTKSGQAILCTIHQPSAMLFQRFDRLLLLAKGGKTVYFGQIGQNSQILMDYFTRNGGPPLPPKANPAEHMLEVIGAAPGTHTDVDWPAAWRQSPEYREVQNELQSLKTSHPSPIPLSGGADPSEYNEFASPLSTQLWEVTKRLFIQYWRSPGYMYSKAILTVGASLFIGLSVMDGENTMRGLQNQMFGVFIFLTIFSQVAEQMMPAFVEQRTLYEARERPAKTYSWQSFMFANLTVEIVWNSFIGIFAFICWYFPIGLYRNAEYTNEVHSRGITIFLHVWMFFLLASSFAHMIIAGLPNADTAGGVMNLLFIMMFAFCGVLAGPDALPGFWIFMYRVNPFTYVVEGFLGTTLANAPVTCADNEILEFKPANGTCEEFLSDYMSNMGGYLVGETAGSKTQCQYCPMVDTNTFLKGINVSFDNRWRDFGLLWVYVFFNCAAAVAIYWLARVPRRRKDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ95</accession>
    <name>S0DZ95_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_02942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428798.1">
        <property type="nucleotide sequence ID" value="XM_023574732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ95"/>
    <dbReference type="STRING" id="1279085.S0DZ95"/>
    <dbReference type="GeneID" id="35396424"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02942"/>
    <dbReference type="HOGENOM" id="CLU_062853_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT66717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="217" mass="24173" checksum="2B9A9A1C8FA5976D" modified="2013-09-18" version="1">MSKITVANVRTQVGELLEYSNETKKRNFLETVELQIGLKNYDPQRDKRFSGTIRLPSIPRPNMSICILGDQHDIDRAKHGGVDAMSADDLKKLNKNKKLIKKLARKYDAFVASEALIKQIPRLLGPGLSKAGKFPTPVSHADDLTGRINEVKSTIKFQLKKVLCMGVAVGNVEMTQEQLVANIMLAINYLVSLLKKGWQNVGSLTIKASMSPPKRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZD5</accession>
    <name>S0DZD5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to calponin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427924.1">
        <property type="nucleotide sequence ID" value="XM_023574598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZD5"/>
    <dbReference type="STRING" id="1279085.S0DZD5"/>
    <dbReference type="GeneID" id="35396303"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02821"/>
    <dbReference type="HOGENOM" id="CLU_024074_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21210">
        <property type="entry name" value="CH_SCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="657" mass="73488" checksum="88E71A442A2900B4" modified="2013-09-18" version="1">MASVSSLDKDLRKMRLEKYTPAAANEARSWIEDILGESLPSSDLLEGLKDGVALCKLANLALPPPGVRFKQSAMPFVQMENISLFLRACQSPPLNLHQHDTFLTVDLFEQKDPAQVLQCIGAFSRAAHAANPHHFPTSIGPKNRPETVTPQGTGSRTPTRTRDRGASVTSNKSPAFGRSAALPHRTGDSGSGRWSPTKSPTPKNRPESPGAVSSWSKKEHEGTTAPAWNIAQYGYLGGASQGNLGISFGGRRQITNAGPRVPTLAEKERRRKEEEERARREAEEEERQRAEEEDRARVEEELRWEQETEQLREKERQAAEEEKRRWEEEERQWKLTEEKRRKDEEDAEARLAEERKSVKNRGDSKLTGQFLSQYRAADQGASQQDGASEDEYKNRVKQLEQELELARQREAEYERERQERAQRQEIIETKPTPKPKPKLVSSPPTRSDSWSKDEREVLRTRSPFNREPLQTNNAHALPSRSPRPLPDPTALPQAKSQNTSSRPLPDPATYSPKPTPAAPSRTDRFLSSNPAPSPPAAQATYSRELGATAERDAEDQRRAQSQNKTKAGGWASKSLLEREMEMERQRQREWEEAQKETAAAVRSNEGVDGIGGGIGGRWDVGQWAGYTGGDSQNKGSVGIGAGRRQIVGPRPLPEQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZH2</accession>
    <name>S0DZH2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to putative trehalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430016.1">
        <property type="nucleotide sequence ID" value="XM_023576498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZH2"/>
    <dbReference type="STRING" id="1279085.S0DZH2"/>
    <dbReference type="GeneID" id="35407932"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14551"/>
    <dbReference type="HOGENOM" id="CLU_030612_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485110" evidence="1">
        <location>
            <begin position="19"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="474" mass="54107" checksum="061A723741BE5F0A" modified="2013-09-18" version="1">MKPHLALTLLFAPLCTAADENIKVDALEQNNPDLASIPNLVCLLLFLLVAAYKLRKRMLTATTTFPQLTRESQSGSVVTSLEQFSCNPDTPRHVEAKKKLDKSMAIGWGNWNAQHPRHRLLDALYGYRRYHERQKAEVDRFEGLYKHVSRAQRSLLEHQVNYSKKFTRIDALLRKNQELCDAIVQNAMKFYGIDEEELQRHISAAQSSGRLADKISVSQALKHYIRDWTEEGESERKETFTCLVKTLQGLFPMRDDENPVKILVPGSGLGRLGHDIARLGGFEVTVNEWSMYMNIAYRFIEANRAQNAHSFHPFIDGWSHHATESDMIRKLTFPDTALNSTSVVLTEGDFTTVFNDKTHYYDIIVTYFFIDTARNLMSYIDTIKKVLKPGGHWVNLGPLLYGTGPFVQLTLEEIVQVTEAMGFEYLDTDESCGPLTFEGRTLRSMEAVYGFNNKALTKSAYNAQFWVARRSMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E078</accession>
    <name>S0E078_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430349.1">
        <property type="nucleotide sequence ID" value="XM_023577249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E078"/>
    <dbReference type="GeneID" id="35400518"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07041"/>
    <dbReference type="HOGENOM" id="CLU_028489_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="514" mass="59534" checksum="43AA83B526E4AD83" modified="2013-09-18" version="1">MGLQTTLLAAKPPSDSPSPPNKPVISMHHGEAEWTAVYPIIERLYMKDRRKLRHIMQIMEEKHNFKASVQMYKRRFTKWGFYKSKQRNVKTACKNKTTTPKNTSEAQKQPNAAPCHRQSLILSPSPDPLETSSLEFLTSIHDWSNSFYESLYTDGLYLQNIHSPPRTAKINRYDPEGLSFAFRTIVELIQRGKGVLAGRLTRKAFLDIENMLQVEAPLFIWNVLEIMYHMVRLGQTQLLGMLLMQLVELASNTHEMQHPVIKMLKSLQKAVYLWEKHATLEKMKLLEQAWSLNANIICRNYDSRLLVMYYRLVWESSCIKLGEDQLDGLDKWFSAVKSKIPHEDPYFQQAVLFNDSNSKEETELPRDYKITKALCVSAIQHRCTMTFGESNIASLVRLGLLKSRVLDEIDEQPSEEILQSHTRFQARVMAYLMKVLMDVDMGLGLDVDVADRMRNKIALREFGYSNTSPQVIHDMWQLEAFLQKQGHVAEAANIRMETYKRLEEYVDQVPVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0N2</accession>
    <name>S0E0N2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428339.1">
        <property type="nucleotide sequence ID" value="XM_023575099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0N2"/>
    <dbReference type="STRING" id="1279085.S0E0N2"/>
    <dbReference type="GeneID" id="35396753"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03271"/>
    <dbReference type="HOGENOM" id="CLU_1886050_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013356991" evidence="2">
        <location>
            <begin position="16"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="140" mass="14412" checksum="6E2F89B067EB3182" modified="2013-09-18" version="1">MRFFAVAALLSVALAAPAYDKADGTCCCCDISKPATVCKKDVKPEDCFCAAVVCPAGAPTIWATSSTSPATTTTAAPVKREEKTPTPAGPPCCCCDPSKNAIVCTVRAEVEDNSCICPMVMCPADASTLTVYSTAMETGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0W6</accession>
    <name>S0E0W6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to vacuolar protein VAC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430501.1">
        <property type="nucleotide sequence ID" value="XM_023577426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0W6"/>
    <dbReference type="STRING" id="1279085.S0E0W6"/>
    <dbReference type="GeneID" id="35400678"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07201"/>
    <dbReference type="HOGENOM" id="CLU_010147_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="873" mass="94720" checksum="DA1E25DEE7E2023B" modified="2013-09-18" version="1">MDKSSAVLDGTSGVGRASRNVTDPSATPSSATTGSQNSKQSSANNSVGPSPLASRDSSPTRRPRRTASANRLPGNRSRKNSQTDNSPSRTTRPSLSSAAPSRSLSSTNTPTLAPSQEQQQQQQQQQQQQQQQQQQQQQIQAPTPQKPGLNAELKDSPRWPVSPRLRSPPPQFSNRPAIPARRSEQDLPSISVQRPTPSPQPMEQQTISESEMEESQYPSGMRTPARVALETVQEVSLPNSPNPPNGSALVERVKEKLSSTDNYSDTALPDGRALRAKNSLVGQESGSDTSNNKAETRRPTSVPPPIITRQSSAMSNKQMKSKQDGSIQTMTVETETVPSVPQVALTTAQKSEGTNGTLKTKQSTETIKPKKDKKKVTRKQPPVNAGNGEPELVTLTLRDVANIHPASSKADVFEATIASAVDEANTSDSEETFVYDSNPPDGNDRAGRRFHSRTPSATSMASQADRQNLRSIYGIMESGGPAHGPKKTMKFVNTFTSNGNESLAVETEDGKGSNRSGGSGSTRGTTRHHHHIGRWGRQPGNGHASLFDNESPFPNAARSKLAGPNSRNSSGPPSPRNAHSNAPRHFGHKRSAMQMSSSYDMDDTTGADDERTPLLGSVRSGRSGRNRRGPHNLRQAESQTFARRSSYLNRFAACLVLTMMFMLVITGAIGFMFATSQPMTGIEITAIHNVVTSDQVLMFDLTVKAHNPNIVVVTIDHANLEVFAKSEYTGTDSDWWARPFPHGPDDIRVSDDPENDPPLDDPDPDDDLRPNVLLGRITEFDSPLTFEGSLFHQGTSSSTGEMQLEYPLNNTVGGSRRWERIYQNEFDLIVKGVVKYTLPMSARIRSATVSGRKAVSPNSSNDPSNSTKVEPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E147</accession>
    <name>S0E147_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_07185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430485.1">
        <property type="nucleotide sequence ID" value="XM_023577409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E147"/>
    <dbReference type="STRING" id="1279085.S0E147"/>
    <dbReference type="GeneID" id="35400662"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07185"/>
    <dbReference type="HOGENOM" id="CLU_047993_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="11">
        <location>
            <begin position="228"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT68405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="386" mass="42851" checksum="C855B1E3BBFFC87D" modified="2013-09-18" version="1">MLIGVCGSICSGKRTVAQYLVEHHGFKLLHLQPQSQPRPSNTSLGAESASSEEHDAESPSQSTDSTAFKGALTSTALTTKNGYQSSSETTLTLRDGPQHVFSTAEELLDFVTKRWRSRFVTTDIPTEAVLDVFLRRPFFLLLSVDAPLTVRWRRFQDRARQRHAGEPDMSLEDFVRESDIHLYDAEKGLSPLISRAVVRLLNTSSSLAHLYATLGKLDIPNPDRLRPCWDTYFMELASLAAQRSNCMKRRVGCVLVGKERRVISTGYNGTPRGLQNCTEGGCPRCNDGNSSGVGLSTCLCIHAEENALLEAGRERIREGSVLYCDTCPCLTCSIKICQVGISEVVYAHTYSMDNDTARVFREAGVKLRQFIPPPNGLIHLEKMELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E149</accession>
    <name>S0E149_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429488.1">
        <property type="nucleotide sequence ID" value="XM_023576321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E149"/>
    <dbReference type="STRING" id="1279085.S0E149"/>
    <dbReference type="GeneID" id="35407070"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13616"/>
    <dbReference type="HOGENOM" id="CLU_036100_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT67407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="408" mass="45282" checksum="84075B7D0B9288E9" modified="2013-09-18" version="1">MDDSKIVSSKVSLTLELPPSCVQFCKLHPNLFVVGTYNLERNEDAQKETDHDDDTDAANATKTLQSRNGSLLVFNVVGDDVHLVQTVSQPSAILDLRFHPRKGREDIMAVISSTGTLAVFKLDPKANPSTPLQHISTSRCDDIAEDILFLQCSWHPEIPHLIGITTSTGSARILHLDEGYRITQNYTDLGITNSLEAWCIAFSPATPVSTTNKAQVAAYCGGDDSMLRYTSCIWDSSEPGSPCEEPYSPATIKGTHDAGVTSILPLFRLTKNSGRVVVTGSYDDHLRVFVIHDLHESYGMKKVELVLEQNLGGGVWRLDLVKTQDSKESIKVRILASCMHAGARLLDLEVKNDKDWSCRILARFEEHKSMNYGSDFIRDTEPSDVVRCVSTSFYDKLLCLWQYAPANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2T6</accession>
    <name>S0E2T6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to transcriptional activator Mut3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_07921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431070.1">
        <property type="nucleotide sequence ID" value="XM_023578227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2T6"/>
    <dbReference type="STRING" id="1279085.S0E2T6"/>
    <dbReference type="GeneID" id="35401398"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07921"/>
    <dbReference type="HOGENOM" id="CLU_010084_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT68990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="961" mass="107173" checksum="29D383E587C07C04" modified="2013-09-18" version="1">MPPDVGDNDAGQSAHDWHDDAPSPSASIKSDNDLDEDGNPQPGASSQPIQKRRRVTRACDECRRKKIKCDGKQPCTHCSVYSYECTYDKPSNRRRNPAPQYIEALESRLQRAESLLHKFMPDVDLADPNLDPAIQQEFRNRENARAQASKARQPPPPPPQPEQNEAHLTSMIDSVGQLDIDEKGSLEFHGNSSGAVFLKRMKDHFRGMLGSSSKAPFLPRAERPAGLESPSLSSVGTPFSTAPSYPELPPKDVARKLCYYSLSCATCLVRILHVPTFYEQMDKIYERPLDNLTKDETQYLGLLFSVMSLGCMYNNLDDNDPGSMPYQDATEEGLKYYNAARSVLHDVTDCRDLISLQALLFIILFLQATSNLSSCYSFVGIALRSSLRIGLHRHLQHEKIDPIEQEVRKRVFYVVRQMDIYVSTLLGFPLLLNVDDIDQPFPLEVDDEFITHTGILRPPPGSPSFFQAFNAHSELMEILAKVTKYVYPTKGLGQTAAKDNKPASTYLISYGRIKEIEAELHSWFERLPQHWRPSGEGPIETVRIRHLLRFAYAHVQLVLYRPFLHYVSPRLSQGSKVDELSYACAAAAISVSRNIVHIGLEIRKQRVLSGPYWFMLYTEFFAVLSLVFYATENPEKPGSGEVLADARAGRQMIAALAEKSMSAERVTGALKALFDQLPEQLDAGAIRQAPSKKRPAPTGRPSSVSSHHTPIPASMSSIGTTDFTRASQMSTSSYPTTLSQGTMDLPGGGMTAFQDNTFSANFGDFMSPDLQRSTPESTSSAATSTQRYPYAGQQMGMHNPVNKLDSLMFPSEDPFAYPNQPMMELGFPGKTDQPTTMGDQNQDMQLFLTGTFDDVESQIFGQPPPYMMHQQGQPMMSAPSHQPMFASPSAIMGMQPGQPMMQQRRPVSQTHAIHQGHAMSNRRAHAQRHQERQIQQMFTEQGMQADWGGFFGSGRGGFQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2U5</accession>
    <name>S0E2U5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to DUF1168 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429084.1">
        <property type="nucleotide sequence ID" value="XM_023575833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2U5"/>
    <dbReference type="STRING" id="1279085.S0E2U5"/>
    <dbReference type="GeneID" id="35406634"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13180"/>
    <dbReference type="HOGENOM" id="CLU_079129_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="212" mass="23232" checksum="6496ADCB9A2EFD30" modified="2013-09-18" version="1">MSAPGPESVPTSADPRSHRPTKKRALTPVSAQAASVEALFSKPDQIIRIPESSTSGSGSSALLSAPPEIVTNVQGSSAGAGSGEFHVYKASRRREYERLRSMDEDLRREKDIEEFNKDKTERDRKDEERTRKNREKREKMKARKSKKGKSPATTDKAPNAIQSKDASSLAANDTEKDTADVDSKTKAEHGRDDTESTPSIQPAGLVIHDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3U6</accession>
    <name>S0E3U6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP-1 complex subunit sigma-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sigma1-adaptin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_07411</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431440.1">
        <property type="nucleotide sequence ID" value="XM_023577659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3U6"/>
    <dbReference type="STRING" id="1279085.S0E3U6"/>
    <dbReference type="GeneID" id="35400888"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07411"/>
    <dbReference type="HOGENOM" id="CLU_037043_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="12">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT69360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="508" mass="57891" checksum="807FAC1B9BF9D83C" modified="2013-09-18" version="1">MAIQYLILLSRQGKVRLAKWFTTLSPKDKAKIVKDVSQLVLARRTRMCNFLEYKDTKIVYRRYASLFFIAGCSSEDNELITLEIIHRYVEQMDKYYGNVCELDIIFSFTKAYYILDEILLAGELQETSKKNVLRCIGQQDSLEDMESVASRIYGPAHQHRDIPTTESTSKCPSASKMKYLPVQDFEAVTSALNFNTPDCSVTGGCDLYTTKSTGSDKKLYKNIDNDLNSQHEALLKLGASLSPPERAHMLATSPSMQLFSHSSAFGPLSELSSRKTFAYLIATLNASHPHYDFSHVLRPNDFKRERNLRRVMVNLDSILQNVRPNFEPKSLGSSLGSETTSIWGPQCWSLIDKEMHLNECTIFSYNPESDPFEEDESAIWASHYFFFNRTLKRVAYLYVRVVPVISSHSPTLRPTNLARNHSNQRDLASAGAQKRANYWLGDQDAELVPYNEDDEELIDDGLFWNRGENGDLVAYSDEDFDEDIEDMDMLDSSPDRSMSDDVAGRMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4E9</accession>
    <name>S0E4E9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_07330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430622.1">
        <property type="nucleotide sequence ID" value="XM_023577570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4E9"/>
    <dbReference type="STRING" id="1279085.S0E4E9"/>
    <dbReference type="GeneID" id="35400807"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07330"/>
    <dbReference type="HOGENOM" id="CLU_030231_0_1_1"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT68542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="445" mass="47445" checksum="40B014111A90B0F7" modified="2013-09-18" version="1">MSLTNASPEAAASAAKTASFTLATLPASERNNALEAIHAALTASKDEILAANAKDLELARKAADEGGLSQALVSRLDLGKKGKWEDMLKGILDVRDLNDPIGQIQMRTKLDDDLIMERVSCPIGVLLIIFEARPEVIANIASLAIKSGNAAILKGGKESTESFVAISKVISSALETTKVPNSAIQLVTTRDVISQLLAQDRYIDLVIPRGSNELVRYIKESTKIPVLGHADGICHIYLTASANKEKAITAIVDSKTSYPAACNAVETLLVQESALNTIFPAVASALAAKGVSLRVDESSKAAISSLSLEGVQDATPQDYDTEHLSLTIGVKTVSSIDEAINHINTHGSHHTDAIMSSDSAEAERFMNEVDSAGVYWNAATRLADGMRYGFGTEVGISTNKIHSRGPVGLDGLTIYKYKIRGDYQATADYGDGEGKKPWKHEKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4H9</accession>
    <name>S0E4H9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to MFS drug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_05440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431625.1">
        <property type="nucleotide sequence ID" value="XM_023578651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4H9"/>
    <dbReference type="GeneID" id="35398919"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05440"/>
    <dbReference type="HOGENOM" id="CLU_000960_25_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT69545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="573" mass="61001" checksum="E5FA279E0459581E" modified="2013-09-18" version="1">MTKSQEDDHSTPSSEQVEKAEHGGTPPLDVNYNTHAVKGDDSDGVVDWTWRHAVASISLAGLYVGAQIPLYFVGGSLTYIVKDIGSSEKSSWLPIANTLTIAVVAPFVGYLQDLFGRRYISLAGGVTILIGVILVGTTHTFGQAVVGMSLAGAGAAVGELTALAGIAELVPVKKRGFYLALVTFFVIPFVPYVMYGQILSAYHTWRWGMWISLIYNGICLAVVALTYFPQSHRRGEELPKMEILKSIDYVGAFLSIVGLTLFLVALQAGGYSHPWSSAYVLSLLLVGIVLIITFCVWEAKFAKFPMVPGDLFKGQRVVAVAFLVAFVGGLNFYSSINFYPLEALTVFDPEPVQVGLKGLASGLGITIGATVINGALSWFKGNARELLLFSCVMMTAFGGALAAVTPDTPALIYIFGVFSGVGVGGVLVPPATVAITVAPDELIATCVALSLSIRVVGGSIGYSIYYNIFYHKLKSKLPYVVADYAIAAGLPITSATQFVTAYILDPSALASVPGVTPEILKAAAIGSRWGYAYALKYVWLTSIAFGVCAIVACAFIGNTKKYMTNRIAARIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5G1</accession>
    <name>S0E5G1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to TRI15-putative transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431027.1">
        <property type="nucleotide sequence ID" value="XM_023578064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5G1"/>
    <dbReference type="STRING" id="1279085.S0E5G1"/>
    <dbReference type="GeneID" id="35401251"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07774"/>
    <dbReference type="HOGENOM" id="CLU_1189999_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZN622/Rei1/Reh1 zinc finger C2H2-type" evidence="1">
        <location>
            <begin position="85"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="233" mass="27398" checksum="21F90D32172DBB9A" modified="2013-09-18" version="1">MQLGKPWCSTCCINFNTFEEHREHSNVFKIQIRHSGPSIPRYVVEKAMENWDRVKESWNEPSQESTGDWSEVCEVETPEFDEELCLFCRHTSSNFDNNMAHMKACHGFTIPTQKSQDIEPISFVRCLRSIIFDCYECIFCGKQRRTLEGIQHHMVAKNHCHFQMTCEISRFCKEEERFDAQETRESHDTQLVRPAQASHNDGTIIQRPRLQRMPKFLGCESTGDGHHMYEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5R0</accession>
    <name>S0E5R0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable methylcrotonoyl-CoA carboxylase biotin carboxylase chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_06201</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432328.1">
        <property type="nucleotide sequence ID" value="XM_023579500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5R0"/>
    <dbReference type="STRING" id="1279085.S0E5R0"/>
    <dbReference type="GeneID" id="35399678"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06201"/>
    <dbReference type="HOGENOM" id="CLU_000395_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="43"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="159"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="649"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT70249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="733" mass="80630" checksum="DB6453344D7C5BD9" modified="2013-09-18" version="1">MRSTLRANRRLPLKPLTRFLSTSASSASVSSVASSSSAPKHTPINSVLIANRGEIAIRINRTAERLGIRATTVYTDVDVGSWHASSGFQSLALGPANAYLDGEKIIALAKQNGIQALHPGYGFLSENSKFAERCEEEGIVFVGPPASAMADMGHKARSKEIMTAANVPCVPGYHGADQGEQELLEHAKNITFPVLLKSVRGGGGKGMRIVLTEEEFLTQLRSARAEAKASFGEGGEVMLVEKYIIRPRHVEVQVFADKWGNTVALGERDCSVQRRHQKILEESPAPDLDLATRHDLWDKARKAASAVGYVGAGTVEFILDKDTNKFYFMEMNTRLQVEHPVTEMVTGLDLVEWQFRVAAGEKLPLSQEEVEVQMNERGAAIEARIYAENPEKGFIPDSGKLVRAYLPAELQNEDVRLDWGFRSGNTISEAYDGMIAKLIVRGDTRERAIAKLESVLRSYEIVGVATNIEFLKRLCETDAFVAGDVETGFIDKWREELFKPRPIKNEVVAQAALGMINLELRNSSPHGLTLGFGETNNIGERKLSFKILDGYSKEEGEVVEASVTQTGRNLYNVAVHRKGDEAPQVFTNIACQPEPEGEVMKLESYFPLERIQSSVVPQHTDNDTKVTVFQHGVKTDLVLLPPKWYEKALGLKESSASVAAPMPCKILKNEVVEGQTVQKGAPLVVIESMKMETIIRSPQDGIIKKLAHKEGDICKAGTVLVLFEESETKDGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5W4</accession>
    <name>S0E5W4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_06137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432265.1">
        <property type="nucleotide sequence ID" value="XM_023579427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5W4"/>
    <dbReference type="STRING" id="1279085.S0E5W4"/>
    <dbReference type="GeneID" id="35399614"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06137"/>
    <dbReference type="HOGENOM" id="CLU_076142_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF243">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT70186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="198" mass="22603" checksum="C21EFDD50D6D8D6B" modified="2013-09-18" version="1">MATQYEVEHNVKFAEGRRSGRRVDMSSFFSLLDQIAEPSGDQTPHHNPHATPTPVDTAALFRLLQEQLHQLHTTSPTDDNRDFLESLIMNLEDDINDPPTRLHGVSQEFVDSIDRVNRKTLKKDDDCAICKVPYLEDEYCLVVELPCKGGHRFDLECVGPWLRSKGTCPMCRQDLGKKKEIPVVQDEDEEEDGDMMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6S3</accession>
    <name>S0E6S3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432648.1">
        <property type="nucleotide sequence ID" value="XM_023579889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6S3"/>
    <dbReference type="STRING" id="1279085.S0E6S3"/>
    <dbReference type="GeneID" id="35400029"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06552"/>
    <dbReference type="HOGENOM" id="CLU_052213_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="314" mass="35468" checksum="DEBE8BDD070C9047" modified="2013-09-18" version="1">MSFQETIDELEYSHIQEPSIAEYVQQITPTESPIIQTLKNIPMPVQSKIALSAPDRLFFRLNELMKPTKDLGSLLTTFNYGLYLLTYFDSKAYNLKSKALSFVRPETAFTALPGAADAESSPFARLGSVVANARLTLRLFGLLPIYVRVRKLIRDGESMDPVLYIISFVQCSLCAAFQLLENIAFLTEKGVLMKCGLGWLFNGAGGRVANKYRVAHRAWFLSIICDFARLMREAQIFFAKNHLEKGKITREEAEKAVQWYYDWIRPLAWLPIGWHLSGWMGDKAPGFNLGVQGAAGVLADLRRTAMLWRATQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6V3</accession>
    <name>S0E6V3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to ankyrin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432610.1">
        <property type="nucleotide sequence ID" value="XM_023579843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6V3"/>
    <dbReference type="STRING" id="1279085.S0E6V3"/>
    <dbReference type="GeneID" id="35399987"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06510"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112771" checksum="8C752CD79707B865" modified="2013-09-18" version="1">MEGTPRQHRHYGETSDAPHESQKNYRHCPRDEVRLSYNEYTIAWICALPIEMSAAITMLDQTHKDLPGLDNDINTYKLGSIENKHNIVIACLPKNHYGTNNASNVLTNLVRTFPSIRLGLMVGIGGAAPGAVDIRLGDVVVGTFVTQYDFGKTIGEGEMYSTATPRIPDQLLNTAVSSLEAKHEGGVKEFPRILKERFQRLVEYDRTTLIDNLFITSYDHVDPQAINCDQCDSSKVVERDPRSTKDPVIHHGGIASGNQVMRSSKQRDRLAQQLNIVCFEMEAAGLMNILPCLPIRGICDYSDSHKNKEWQRYAAATAAAYARELLTVLASQPATRLSSARHIPYGIPFSLQDMPVSDHFIDRPADRAALEDCLLPKQGANARRKLFILHGLGGIGKTQLAVDFARRHKTAFSAIFWLDGRSEDQLRHSLANCATRIPELNASNQGSKDELDAAVMAMMTWVSRPDNTRWLLIFDNVDQEHQRGGAYGSYDLRKYLPADQGSILVTTRLSRLQQLGDSKELTNVDHSLSLAIMEEWYGDKLDPDSSSKELLELLELLEGLPLALAQAGSFLRETGIDIPTYLQNYHLQWDRLMSSEDSPLVDYEHGSVATTWAVSLNAVKAENEDSVNILRLWAFINNKDLWFGLFEVVTNRLYTDLWPAWLSNIARDTLRFAKAMGLLLRYSMIQARVEPRGSYSIHPVVHRWVLNLETDAQQRREFASLALCLVGHSVPHETSTAYWTVNQRLLPHADSCSFWICQPEFKQEQNPFESLAIGSLGLLYDDLDKSSQAEEMHVQAMWSLEKTFGREHETTLAIMNNLAISYAKLGKNDEAQEIFDRVLQGKEKVYGHDHPSTLHTISNLASLYTGQGKLSEAKKLCIRALNGMERTLEQDDIPGHLPRDISILETTFTLGHIYKKELQLAKAEELFNMACMGYQRERGSDHPRTLDAFFHLGQVLFLQGKLTQAKEMIVKSVEGYKKTLGPANKQTLKRISFLEVLFASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0E7X4</accession>
    <name>S0E7X4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to IMP1 Protease, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_08963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433083.1">
        <property type="nucleotide sequence ID" value="XM_023580278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E7X4"/>
    <dbReference type="STRING" id="1279085.S0E7X4"/>
    <dbReference type="GeneID" id="35402437"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08963"/>
    <dbReference type="HOGENOM" id="CLU_028723_4_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000015">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT71004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="168" mass="18655" checksum="FC8CBE0C966C7157" modified="2013-09-18" version="1">MASFHFARRPVQTTVSFLKAACLVHLGITYGYTISPAQGPSMLPTFTVDGDWILCDHTRRYGRGVSVGDLVVYRIPIFNNQWGVKRVTGMPGDYVSVGTPGEQGEELMIQIPEGHCWISGDNLPASRDSRHFGPLPLALISGTTIAKILPWNERQWMKNGLQKVEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8N8</accession>
    <name>S0E8N8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_07664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430923.1">
        <property type="nucleotide sequence ID" value="XM_023577942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8N8"/>
    <dbReference type="GeneID" id="35401141"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07664"/>
    <dbReference type="HOGENOM" id="CLU_1917131_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="126" mass="14245" checksum="A858959126EE3804" modified="2013-09-18" version="1">MGHLSRIEAVMEAYNDILYHYPDDGEHPLNMPKKKVIVQQKADFNFWAIHSGVCMPELNLEHEFEREAVKGLDNFIETANKQEPSPDVTWRADEHVASLAQMLSQLAHTFGVLVPSLQNTETASGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9D8</accession>
    <name>S0E9D8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to laccase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_08425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433573.1">
        <property type="nucleotide sequence ID" value="XM_023580876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9D8"/>
    <dbReference type="STRING" id="1279085.S0E9D8"/>
    <dbReference type="GeneID" id="35401901"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08425"/>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF71">
        <property type="entry name" value="OXIDOREDUCTASE TPCJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="121"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="242"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="489"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT71494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="659" mass="75499" checksum="AE2DD730807A092E" modified="2013-09-18" version="1">MGFYNVCKSLIAYTATFFSLPLHEHTGGDSEQPVLSFENDQISQNYPKFPAPNGPDSPDEDFICKYPELGNDWKSCSTPENRHCWLKSSDGHNFSIHTDYETMYPPGVLREYWLVVDNKTINGDGIDNPYGKVFNQTYPGPWIKACWGDLIRVHVTNKLRYNGTTVHWHGIRQNGTMEMDGVNGVTQCPIAPEDTFTYEFRALQYGSSWYHSHYSLQYADGLAGPITIFGPSSAHYDEAKDPILITDWNHRSAFQEWERELTGVPTRPEMNSILMNGIGNFAGSFPRERYNITVTKGKKYLLRIINTSVDTTFLFGIDNHYFEVMSSDFVPIHPYTVDHILVGIGQRYHVVLHAKPRNDTKFPASNNGNYWIRTVAADGCKGFEDGNEPDERQGILRYQPVSTEVPQTWRDNWTKDCTDEKYENLKPILPWSIPTVKLDERDRSKDLELGIEKVKDRPHAGDRFSWWAFGERPLWLDFSNPTITLLEERKEWPDDYVIVPAENRDGWVYLVITAPSLDRIGTNKTFRSLAHPLHLHGHDFALLAQGTNSSQINDPNNPVTLKFDNPPRRDVALIPAGGYLIVAFKADNPGSWLFHCHIAWHASSGLALQIMEREEDLRKMMTSEKLKQVNDGCKKWKDWYGDRNNHWNPVGIFQDDSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9L0</accession>
    <name>S0E9L0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable CDC42-GTP-binding protein of RAS superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_08577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433439.1">
        <property type="nucleotide sequence ID" value="XM_023580705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9L0"/>
    <dbReference type="STRING" id="1279085.S0E9L0"/>
    <dbReference type="GeneID" id="35402053"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08577"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT71360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="195" mass="21752" checksum="B8E1DAE14B50DCE7" modified="2013-09-18" version="1">MAVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVRHHCPGVPCLIVGTQVDLRDDPSVREKLSKQKMQPVRREDGERMAKDLGAVKYVECSALTQYKLKDVFDEAIVAALEPPAPKKKSHKCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA13</accession>
    <name>S0EA13_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433835.1">
        <property type="nucleotide sequence ID" value="XM_023581193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA13"/>
    <dbReference type="STRING" id="1279085.S0EA13"/>
    <dbReference type="GeneID" id="35401616"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08140"/>
    <dbReference type="HOGENOM" id="CLU_168472_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485005" evidence="1">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="115" mass="12709" checksum="34FBD8518A58FA65" modified="2013-09-18" version="1">MQFLSLTSLLALATLASAKLHSQAVCVTNRHYDPIGGTPWSPSYNWKVNYEILPGATKCACDYYKSRNTGNKQWDKCPDCRFDGLVCGSNGWHIGGDEFTYYCEKKCGAQGAEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EA50</accession>
    <name>S0EA50_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable mannosyltransferase involved in N-linked and O-linked glycosylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_08131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433843.1">
        <property type="nucleotide sequence ID" value="XM_023581202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EA50"/>
    <dbReference type="STRING" id="1279085.S0EA50"/>
    <dbReference type="GeneID" id="35401608"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08131"/>
    <dbReference type="HOGENOM" id="CLU_024327_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT71764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="407" mass="48178" checksum="F7BE441FC0182F80" modified="2013-09-18" version="1">MRFGSAPVSVKRSRLYLRIIVLIILALGLLVYLRPASIFSESWCNAFDFRSRNCRAEPPAASHVETNNALLKQTPNRPPNQPFRMNATFVTLARNSDVWNIAKSIRQVEDRFNRKYGYDWVFLNEKPFDATFKRVTSALVSGKTYYGLIPPENWSFPDWIDQDKAKKTREDMAQRQIIYGDSVSYRHMCRFESGFFFRQPLMMNYDYYWRVEPDIQLYCDLDYDPFKFMKEQKKKYSFVLSLPEYIETIPTLWDITKQFFESNPGHLSPHNSMDFLSDDNGSTYNKCHFWSNFEIGDLNFFRSQKYLDYFNHLDQAGGFFYERWGDAPIHSIAAGLMLDKSEIHFFDDIAYWHNPFTHCPTDVKKRLELRCHCNPKDNNDWKGYSCTSKFFDSQGMEKPEGYENQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAI8</accession>
    <name>S0EAI8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_08675</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433972.1">
        <property type="nucleotide sequence ID" value="XM_023580597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAI8"/>
    <dbReference type="STRING" id="1279085.S0EAI8"/>
    <dbReference type="GeneID" id="35402151"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08675"/>
    <dbReference type="HOGENOM" id="CLU_141397_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT71894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="87" mass="10067" checksum="0B60D7ABB69676DC" modified="2013-09-18" version="1">MDMLSAAEQRTLEQRMQKRQVKEFMGAFGGLVEHCFMSCVDDFTSKAISTRESGCINRCVQKWMASQQRISDRFQEHNAQLTAQMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAR7</accession>
    <name>S0EAR7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_05431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431618.1">
        <property type="nucleotide sequence ID" value="XM_023578641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAR7"/>
    <dbReference type="STRING" id="1279085.S0EAR7"/>
    <dbReference type="GeneID" id="35398910"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05431"/>
    <dbReference type="HOGENOM" id="CLU_013838_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="256"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT69538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="636" mass="71084" checksum="AAECA3C7C0BC646B" modified="2013-09-18" version="1">MKRGKAVSVYISLGTCHLLRKQDVCLYDLDANRTPSTFLPVELQDQSTNGVLRACPGPIPPALGVVPSEFKPLGYGDSTKGTPGVLRSVGESASLLYQPPPRDCPAPSEYVSMIRELPSQRHIDILVHDFFRNVAWHYDIVDEAAFMNQLAQWRRLTHDQFKRGPDALPTTLRSFPALLFQVLAQTLLFQPAQHIETLNDLKYAVDMELSDRAAEYSDAGRRLASSFRKSEPTLTGVQAELMRACFEKSTGAVIEAWHTLGTAIRDAQELGLHLTEPDSTTYSRSAKSSDREMGRNVWLILHLWDAHMGIVLGRPMSTRISPNDVASPMSSRDSSGNQRPPQPRDVILCGYHTAYKFLQEIHDLEKLEDWRIPVDKIHETILTNIANLPGWATVQRSRQGEPPWLSAALETMYTNVQFVVFALHRPFIFAEPNSRHKAFDAAMQILESQGRLFDQTEPLQYKAFSLVFATFDAMVLVAAVHIRFPDELREQFTATRRILELGIERLKSLQARKNVLANSALSIVERLYQKMLATVYPEETLDNGQGGNDDGSFTIMETETVGANWGTILQPDLGDVLVPQPMNELLRSGYLAQSLSTSPSLPAAYGQDQFGMSIMGSFGYDSMPYNITDDTLHGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>S0EB61</accession>
    <name>S0EB61_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_08566</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433973.1">
        <property type="nucleotide sequence ID" value="XM_023580718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EB61"/>
    <dbReference type="STRING" id="1279085.S0EB61"/>
    <dbReference type="GeneID" id="35402042"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08566"/>
    <dbReference type="HOGENOM" id="CLU_019988_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0946">Virion</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="285"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="241"/>
        </location>
    </feature>
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            <end position="212"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CCT71895.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="523" mass="57737" checksum="1AB559B0CEA6DEEE" modified="2013-09-18" version="1">MVVLAASICTRGGKAVLSRQFREMPRSRIEALLASFPKLADSGTQHTTVEQDNVRFVYQPLDELYMVLITNRQSNILQDIDSLHLFAQVVTSTCKNLDEREILKNAYELLSAFDELVTLGYRENLTISQIKTFLDMESHEERIQEIIARNKELEATEERKRKAKQLEMQRKDAARSGRGAMGGMGGMGSSGGMPRSPSYPSYNPPSQSNTSTYDSYEAEKNKSFSKPLAPKAKGMQLGKKSKTTDMFERVRGDMGGEIDDSPLVAPAPVQHAEAAEPRVSSTLDRDAIHVTISETISAKLSREGAVNSLAISGDLVLRISDPSLTKIKLGLQAEASHGVQFRTHPNVDRNLFNGSKIIQMSNTARGFPVNNAVGVLRWRASPKVDDASTCPITFTVWINKEGAKYNITVEYELTGSDALNDVSVVIPYAGSEPVVSSFDATYDVSGDALEWTIGNVDEENPNGSFEFEAESGDENDFFPMTVRFNKSTPYIDVDVLSASLLEEEEEVTFSKEIKSHADNFLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBQ9</accession>
    <name>S0EBQ9_GIBF5</name>
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            <fullName evidence="8">Related to alcohol/sorbitol dehydrogenase</fullName>
        </submittedName>
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        <name evidence="8" type="ORF">FFUJ_13964</name>
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    <organism evidence="8 9">
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        <name type="common">Bakanae and foot rot disease fungus</name>
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        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        </lineage>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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            <name>Zn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="similarity">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="SMART" id="SM00829"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCT72040.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000016800"/>
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    <sequence length="359" mass="38568" checksum="E75817F72A5CA4E6" modified="2013-09-18" version="1">MSMKAVRFHGQQDVRLEDVPLPSLNSNSVRISPKFCGICGTDVHEYLGGNNLIPKPGTPHGITGETSPLTLGHEFSGIVEEVGSEVTRLQKGDRVCVQPIIYDNECRSCKRGLVNCCDKNGFIGLSGWGGGLCETTVVPQDAVKKLPDNVSLEVGALVEPLAVGWHAIKISPYQEGDSAFVVGGGPIGLAVVQALIGRGCKNIILSEVSSKRREFAKKFGAHHVFDPTKDDIVAEVKKLTDGLGADVGFDAAGSQHAIDAAFDCLKARAVLVNIAVWEKRAQLNMNQIVFRERSYVGCATYALGDFEEVIEALSNGKITPEGMITKVIKMDKVVEEGFQTLINDKDNHVKILVDVSAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECD0</accession>
    <name>S0ECD0_GIBF5</name>
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            <fullName evidence="7">SRm160/300 splicing coactivator</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="5 6">
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        <name type="common">Bakanae and foot rot disease fungus</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
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            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
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    <dbReference type="InterPro" id="IPR056223">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1045"/>
            <end position="1244"/>
        </location>
    </feature>
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        <location>
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            <end position="1399"/>
        </location>
    </feature>
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        <location>
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            <end position="1824"/>
        </location>
    </feature>
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            <end position="171"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1610"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1867"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1898"/>
            <end position="1929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2075" mass="229680" checksum="17F889287CA87941" modified="2013-09-18" version="1">MSSSNPASPEEAVDEAVLDPEPEPETPLKPSTQDENDGKETPKSAPPVAHRGRPRAKSTREPTLLHDFLLGRPSASRQAAERQRRMSLEAVKAELRHEMKQSQVKRIQPPNGVRDRVKKWQKANAAAMENTPDDAATEPPDIAFEDEEFQSVTEEDRVRIKMRKKLKRPSNKTKESLATGDEATPDETPMTPTPAAAKPPPKKRVVSDEHWRKNRKHIPKKTSPAKTPAPAKIPKDFVLRTAANPRVASRVKAWAEMVEIPDPPAPRSHKSSKSVGAKPWTDDTDSEFMSDSEFTVSNVTSSRFTKARSAKSTPGPDDGIRVKPIRRGRNNDDGIRVKAVRTTLTDDEGIRVRPMSDISSNAGTSVRTARLRLKSAPSSRRPSMSSVKREMKKSQSDKSKIEVIEDASEVSTNKFIEVIEDDSELSKTTKTTDKSGLSGTVPIEVVEDDSAIDTPTKKRSVSAHKSKPRSKSYQPPTTKQKGKETWVPEEESAMEPSQLDGSDLSSSILAKSIADIPGEIPWGNSAFTELDLPLRARGGPLRSRPIRPARPAKPERNTSFKSMPKVFKKVVEGANKIIHEMNEHPPPRDTVPNNPRSIEKWLNTTVDPFVEEPKAEPATTPLSEHVPDKPSSPETIKSHRRSSRTEKRRVSSSTMSKPDTADRTVSSEKLPLSPESVKERAKEKPTPSPVPKPGPVKEPAKEPSPEPGPPKKSTPKPKPEPEPEAQPEPAAVKEPAPEEVSPLSSLAPSPEPEAKTKPKRQDTKAPTKAPGGLGLKRTKATRTTSSPVKSSPKNSLFGMLKEAFTGESGNSLPKVKPYQSREERPYDDEPESMYTDSRYSDSRYDDSKYEGSKYDDYHHEESHYDDELTYDDSTENWTETELSKTGRPRTVRSPSPLEEKKKPQSPEQPREPTREPAREPEQNRDDRSALPSARMAGPRLPPPTRGQYELSTILSEEASSAVESDLTTDVTQSTLTQSTGVTKETRRSNSRSNSKSQGSGLKRRLTRHSDLVSVLSLPDDKNVPSAITSNRSRPSMRKSRGGATDVTNDDLLKEFTEDESLYLRELKTLVDGVIPVLLSQVVNGDNATDLFGTSNPVTKADALSKSVVNMGVALEKLRMAHRKAPIHDIRRLASWGHGVVPIYHKYLDAWRLGFQDLVVNLAPAAGSPEDEDSLVGAMPRNESGDIVDATGERVDVAHLLKRPLLRLKQITKFFKCVDSILGTNDTYDLLSDFEDLQEKARRRHREEMARLTDEDAINTDTTRSRDLRTLAPMEAVYIEPSRQVSAKDFFSLDLAHSNGQRLECQIELVHRDNQRYPEDKGDILIRENGVKGRSYLLFPPVPIELISARTGDGNFDMVVMIRGTHNDRPWHELLTLTTDNEDQILDWLDILPVSPVPPREPEPSIIDDEEPYSQSRMPDVPVGVRGSSRKYSAQSLRNSHSRRSSAAESPPASPTTPKRALPARYRPRSASPVTPPPIKSPDQYDLQRTPTQYDYGYEDRPMTSQSMQPDPLNIRKSPSSSSYRDDGAPPPPAHRTFSPSPSQQAPSKPRFSKPPPLEPPNSSRVKRRTSSPLKHEYLPSDQSSISGTDITGSYENTEDDYTESDYSYDSSDDDIESVDLPETELGVSIRDEDPARDIIREELEHQLETLEEEGSLHDYHQRHELHESVVSGSIDSLAPSNSASQAGLHGQKVAPEDNATRYVATISRWSDKGMWKDISGGNLEVIVTPGLIEAYVVHSGAEQGDKPMLALDLTPLVLIRQSTALDLEIRSSVRSDCQLASSHGGGNFRFRCHNGPDCYNLYMSVHHARLNNQKFIELENEARFRSFGEHKPPPDNDDTSSRRRSWFGRKNSYRGSVRAPAQSHDGASTTPSSTLSASSFLKRLTGRGLPFSLARSSVNRNSRYGGTNTPGSSSYGGNTPRSPSISVENSGRGPASFGTEDLKIRLHLLVAAAKWEDFGNCRLSIRRPPPGWRQALRADHGLEKRVTVTTIPRKDSEQPKILLDAVLGSGCFTAMGSRGIVCGVWEEMKGSNGVVGVVPATGPTGGNVKKWCFQCASVAEASWVLRLVHQEVMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDA9</accession>
    <name>S0EDA9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434947.1">
        <property type="nucleotide sequence ID" value="XM_023582408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDA9"/>
    <dbReference type="GeneID" id="35406219"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12763"/>
    <dbReference type="HOGENOM" id="CLU_1102828_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495799" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="26999" checksum="EA75DD44EC171A8A" modified="2013-09-18" version="1">MLVSTALLALCSAAFTAATPAPAQTAETDFSFWLGGPILEKCLAEGNCEDRLLDNPYYVEAKKNKHAKRYSCHGSKIHTVVTTGKNFVKFGSFNPYDLFHHVYDLCHEGGCDSGSDWARSTKYVTATGIYSKDIKVSAQGVYSGWEMRNALAQSLADASGRNQVWSEEVACPSGGRACSRVKAWQGYAPNFHQAAIFNNCNQYGWMNAKTDGLTGITSGGDCKSIVEKLGAIIGEAIPYGAGTIPLLGALCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDK4</accession>
    <name>S0EDK4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434793.1">
        <property type="nucleotide sequence ID" value="XM_023582234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDK4"/>
    <dbReference type="GeneID" id="35406064"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12608"/>
    <dbReference type="HOGENOM" id="CLU_1428098_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="190" mass="21414" checksum="7743DAF71842D9AE" modified="2013-09-18" version="1">MAASSFHKFPELPSEIQLQIWESSFRSPEAIPGGLHYIGLDHDGFPVPLDKSAKDEFRRPRSGCELEQGIWTACWDSRAAAMKHQEQQDVEFSCSSFGLTTLDFTLDKREWYHGRGPVSIIPPIDQGQRNNESQQQKIFICPSRDVFCVAFNRAGRAVGTVTHCEYSEDSPSNSRLLGTSSYHRMTTTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDM1</accession>
    <name>S0EDM1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_12627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434813.1">
        <property type="nucleotide sequence ID" value="XM_023582256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDM1"/>
    <dbReference type="GeneID" id="35406083"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12627"/>
    <dbReference type="HOGENOM" id="CLU_667395_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT72735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="412" mass="45895" checksum="97FF14E19B51C941" modified="2013-09-18" version="1">MTSLLVTGGLFILSNVGKSILGKGAGWVFDQGLASLDGGSDNDKIRQDIANVLTEVKQIETSVASLSNQLSDTLLQLRKDDLGTYITDIETYYSTIGDIMQEAFDLPRKNLTDSVRVSQAQSLQSRLDDRLQASSDNVPGYLDQINAFLNDASANSFLKQAAQQAFDESDDFLGYFTKTKVMALNYWVAYAKGISLLQMALDNPKVNFEEGSYTISRHNANFVAQEQIFEDTVGQESITLAEGIISNPLDTHDFIWRVQSGLYIEDAFSDYQNWIGSDAENPRSSWSMFNGPPITIDQFDPTGSYPVVLIPSDNQDRMLCVGGQYGLQIQEQWPDKTVTPSCRWLIKPRYPGADRFSFKFDDNYAGGEYNGSYIVDTSYEEDMRILNFVDALDNGDGDQFFNVTLGQLNLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDS1</accession>
    <name>S0EDS1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7908 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT73004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435082.1">
        <property type="nucleotide sequence ID" value="XM_023567755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDS1"/>
    <dbReference type="STRING" id="1279085.S0EDS1"/>
    <dbReference type="GeneID" id="35406358"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12902"/>
    <dbReference type="HOGENOM" id="CLU_407700_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495872" description="DUF7908 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7908" evidence="3">
        <location>
            <begin position="147"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="742" mass="75600" checksum="58B040A55A247C3F" modified="2013-09-18" version="1">MRPSTIFVPLLGLYDLVLASDLAAIESDLWCVTYLSTYLMPVSNSIAISTDINSATTAISSTTSNSSTSEPSSLKTKTTEAHSSFKQTSSRSLTLTTTDQLNSSQIQTQPSTTLGTTDRPISSITPTSSTTASTGVTTTSIPQPSGRSIIFQIQPPTTNRRRNIKRAPVGGFVGGTQVCTFALDFTLSAEGQLLAGGVPVFYAGEDFKPLSEQEAISNSGDVISKTFTESNGLLVFKNSSLPTGEAGFCQTSNGIVYITFSSQPSGCVPVALRIYEIQQCQNGRIIDGSTTSSSATSTSEAGSSRATASTTTIQSETTTPSSESTESREPATSTMISSTSSSSTNTTPLSATVSSDLSSEGTPSTTLESTSEITSVVTDTTILTSTENATSDDISSIQSSAESPTSSATTTDSSSTGDTAAISTMSSKSSSISISSTTTSSTSSLIMTSSASGSTSSLSSTSTSDLALTSTTSSMPASSTSSLTSSSTTSSTTSKTTDSTSELTTSSTSDSTSSSTDMTTSSPSSSDLTTSSTSESSSESTSSSTDLTTSSTSSSDFTTTSTSSSDLTTSSSSTADLTSTDSTSSTTSSETSTTTSAAPSLVQDGGFEDNPNTAWTLSGSAAIVNNPGMALSGNQYLQLSVVNGLPSASASQTGLVSSPNSMSLSYVVMDSPTPSGVSQCSFRVMTAGNLVAAFDVNTTPNVWQSESFGVWGSGSSWTIELYLYCSQGPATFAIGVDNVSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EEI6</accession>
    <name>S0EEI6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_09154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432907.1">
        <property type="nucleotide sequence ID" value="XM_023580066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EEI6"/>
    <dbReference type="STRING" id="1279085.S0EEI6"/>
    <dbReference type="GeneID" id="35402628"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09154"/>
    <dbReference type="HOGENOM" id="CLU_065609_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010634">
        <property type="entry name" value="DUF1223"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36057">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36057:SF1">
        <property type="entry name" value="LIPOPROTEIN LIPID ATTACHMENT SITE-LIKE PROTEIN, PUTATIVE (DUF1223)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06764">
        <property type="entry name" value="DUF1223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="261" mass="28817" checksum="2F181192DD78402C" modified="2013-09-18" version="1">MATILRKLFHRKKQPPLVCSISLDDQGYPMGEDPDHKHTAGCFIDFEPLAVVELFQSQSCQACFPAISGILQGANHPTLLLLTYNVTLFDHMGWKDTFAKSAWDQRQRAYAMKQQHKTIFTPQVIVNGVADGSGAGSKESIQEIVQRARAVQIDRPWHIYLDANDTDVRIDSDAEMAEEHDIIIILFRSGDEKVKIGKGPNKGVKFDHRNVVTDMLKIGKWTGGDVTLRLPASKNSMKPGENAVVLVQEGSGGPIVAVAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EET3</accession>
    <name>S0EET3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT70893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432972.1">
        <property type="nucleotide sequence ID" value="XM_023580145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EET3"/>
    <dbReference type="STRING" id="1279085.S0EET3"/>
    <dbReference type="GeneID" id="35402557"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09083"/>
    <dbReference type="HOGENOM" id="CLU_025462_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="387" mass="44944" checksum="22958F929B0292B8" modified="2013-09-18" version="1">MSILLKSMDLRQEAVLIAFAAVGLCLFAVYEWMRKGKAAVKTHVEWKTPSPTPLVDFDLDAKKPELYRPCRHGPNHVTMGIRKMDWNNWIEMDSNFLWYHDIKVSELEKDIDAHVQYVDNAVTRDACFEVLEELTAYLTVRYPKIFRLSNGILRNTLTKEEFKYPASTSKEAMTTAAKLVQDDLIIMVEEDDGQYHLDAGAVCLPGFWRLSEKFRMSLDTLHIEAKVPHYQTKLQKSMNRFFKTMQPDKAVIRNNFFIQLDDGLHWSHRMGDQDSSEVASWETANDKGLTINDLYFRSERQSLRRLPRSKALLFTVRTYFEPITTIAQEPHVPGRLAEAIENWDEAASKYKGKHHWADILLPYLYDQDELQKKSGVLEKIPEGSFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EET6</accession>
    <name>S0EET6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_09724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435554.1">
        <property type="nucleotide sequence ID" value="XM_023568342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EET6"/>
    <dbReference type="STRING" id="1279085.S0EET6"/>
    <dbReference type="GeneID" id="35403192"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09724"/>
    <dbReference type="HOGENOM" id="CLU_019618_1_0_1"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="22"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT73476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="549" mass="60994" checksum="6EB1F71D41163640" modified="2013-09-18" version="1">MADVMVQTPPVLQGPSEKERKYDRQLRLWAASGQAALESANILLVNSGAGTVGVETLKNLVLPGIGRFTIADQNVVTHQDLGVNFFVDDSWLGKSRAEACTDFLLELNPEVQGEWYPKPQDESFHLDHFLSSSPTFTMILYALPLPQDQVQLIRGYSHQHKIPTIAVHSVGYYSYFKTTLPGTFPIVDTHPDETATTDLRLLAPWPELLEFSQSMTENIDNLDSHEHGHLPMVVILFHYLEQWKQAHGGAYPTSYVDKTAFRKTVSEAMRTDNPEGGEENFEEAIAAVMKHVVKPSLPSSLQQVFDHVHQDPVRISAIIVNFIANLCQEETTSSFWVITEAVKRFYDQHGRLPVPGGLPDMKAQSNVYIKLQNIYKERARQDVGQVLETARSLPGGQDVDPEQVELFCKNASFIKLINASGDKSISLDKLVEQELANDEISAFAGPEMPLSLVPLYLALLATSNTKTASADDIMDFVGKAAPKATENERYKKTAQEVERAAGGELHNISALTGGMVAQEMIKIITKQYVPIDNTCIFDGIDSRCQVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF34</accession>
    <name>S0EF34_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435388.1">
        <property type="nucleotide sequence ID" value="XM_023568029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF34"/>
    <dbReference type="STRING" id="1279085.S0EF34"/>
    <dbReference type="GeneID" id="35403472"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10005"/>
    <dbReference type="HOGENOM" id="CLU_048145_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="473" mass="51729" checksum="0FB8F1BDF19A9EC4" modified="2013-09-18" version="1">MSKASTASAWPGAPPAAEDGFAFADGVFFAQSSGQNRHRRATATELKEHFTSGNDKDHPAHWFEAQLIHYGLPPSKTKSVARMRLFDAVNAGNLKVPASVSKLETKLKKEWTKNDREAKKGGASKPAVQATPVKTETKKPTAVGAKRKANDDESNAKVKKPKTATPKTATPKAKAPAKTPAKAPVKSTVKTAAKDPETGPAPTPARKPQTARCVRGGASQGPGRGASTAATEPAKQPRTKQTAPRGNGSRRSTGPSRPTARDPSPEAPRFAKPQTARRGGAFAARGRIPAPSGYDDAPPPYSEFPDQDYSSDENNGSDDVGEVSLAPLGLLNGDYEVESLDVSEQWDFDPDEFQLTLTISGNRLWGKFDLGVYKGVLLFEERPMRSSHDRVWFKWRGREDQGPIMYGDRNEGWMEFLGDGRIEGWLNHQSLSFQARRLPGQGTRSSIDARTLQDEWNGYSYDLYEEENRARWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFM3</accession>
    <name>S0EFM3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to ADP-ribosylation factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433267.1">
        <property type="nucleotide sequence ID" value="XM_023580500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFM3"/>
    <dbReference type="STRING" id="1279085.S0EFM3"/>
    <dbReference type="GeneID" id="35402238"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08762"/>
    <dbReference type="HOGENOM" id="CLU_040729_10_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001015">
        <property type="entry name" value="ADP-ribosylation factor-like protein 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="184" mass="20889" checksum="1C078EEF1E392541" modified="2013-09-18" version="1">MAGLFQRVYNWLMRMFWAMEMEVTMVGLQNAGKTSLLRVLAGGEFTLDSIPTVGFNMKKVQRGHVTLKCWDIGGQPRFRTMWERYCRGVSAIVFIVDIADTPLIPQAKEELHDLMSRKSLEGIPLLILGNKSDLPDKLSVDELIDELDLKSIRGREVCCYGISAKEETNLDAVVEFLMKYATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFS9</accession>
    <name>S0EFS9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to HHE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435934.1">
        <property type="nucleotide sequence ID" value="XM_023568792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFS9"/>
    <dbReference type="STRING" id="1279085.S0EFS9"/>
    <dbReference type="GeneID" id="35402788"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09319"/>
    <dbReference type="HOGENOM" id="CLU_079417_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="212" mass="24327" checksum="9596A06C84AEB04E" modified="2013-09-18" version="1">MSSIRSIMSPQLRTVFRPQHFRSIQGPIRVQIATMSAVSNAIVKDHLNSTDHDHQQRFGNQFVWELARHSISEELVIYPAMEKYMGDKGRRLADEDREEHHQVKERLKVFQNLKSTDPGYVPEIKHIWGLLDKHIEDEENRDLPALEKALAAHAEDADSLAASFERTKHFVPTRSHPSAGESPPFETVMGLLAAPIDRLADMFRKFPDKRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFX8</accession>
    <name>S0EFX8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_08647</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433372.1">
        <property type="nucleotide sequence ID" value="XM_023580627.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EFX8"/>
    <dbReference type="GeneID" id="35402123"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08647"/>
    <dbReference type="HOGENOM" id="CLU_001331_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="708"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="893"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1109"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1307"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1475"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1116"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1319"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1475"/>
            <end position="1539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT71293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1548" mass="167674" checksum="5358F5B2E5F1D7B6" modified="2013-09-18" version="1">MTEVGAADLSRLLQTKRNECSSIVTSRKRKLRELFAVATQSEGLPHPVLTNPDAPTTTPAEWQFLQANDIIQGKTLNEASIPARPPISLELFKKSLAKAIFIAPEPTPKRTLEDASKPETANVQNKEQSNGTYPPPKVGDAPPKRTPSPPPSTDPATTDKASSLPTPTSQPVPLPEDAIVEPTLTTSPMTQTATDTNVNPKSKAEDIPNASEASDTPAPRQPQVTFESGTKGENTRPGVSTAEKTSRGPSTSSDARGGALTVKPPTDAARAPDALSSPGSTAQSATTPAVHDDASTDTSPEHEGPQFVEPAEEKMTKDEVDEGVHEKDDEKESSHDVEATLNQDIQNRVLEAPPDSAEAQLLQESIRSSVAAEATATATATATATATATATATETATAARTGQQTKPVTSAPVSEDVNMSGANDVVQPIASNANEQVKEDSTQAKSDIDIARVNAFENSVEAPGIKEIPDSQEEPPEQMDVDVPEPKATIQAQTQSQEVKSDGSTQATEKAPSTPTPAPISDVATVPVESAPKESPPKVERAVTRVSSGAMRPKSVSEIVGATPRQTPSLEHTSTNKSLDSQLTPLTSTPKSPSLRHRHISAHQRQRSRSQPSTVVFGKQSKKADERSIVASQRDPIIPTEDYYTPLFVQGFAGSSSWMQPIEKILYTANKTVTTPDANLAIQDHQACKVLRRVYHLQQHDKWSLRQPKRCPEPTRPPSHWDVMLQEMKWMRTDFREERKWKRAVAKNLAYACAEWHESTPEERKLMQVSAVIPPKTQPAPDVSMADVEGENQLTPDLISSGDVESIDNLDDLTEDFPETIAPSAIFSLQDDDVIFGLRRTAAADQLLEELPMFGKPLQVPKFDLTGPEWDPDAHWRRPALPLSKYVEGHMKLVSDGPPRKRSRYDYQNEDSDDEGETGFVTSGPSPSLPLPPATDEVALFNPEMKHIRDRLYVGHQFRPPSEYPMPLQSFFECRNPSQWTINEDDELRNLVREYSYNWSLIASMLAPKSRFTSGAERRSPWECFERWISLEGLPADMSKTQYFKAYTGRIAAAQNFIAQQNQLALQQINPANGAVTPGRRRPPSTPVRVERRRNQKHLTLLDAMRKLAKKRETAAQKQQHTASQNAANKKVNDPASQRTNKTPRDYSIMRHERDQALAEKMAQYASKQEAQRRAALQARVQGPAQMAGTPGAAHVGQNAAQVAAAAAVAAANGMNGVGRLNVPNQLAVAAAAAAGQARPRMPMQSPAPNGMGAVPSQMAGGLVPPNQMTSAQQAQLQAMQGQHNRMPMPNPQPDVNLMMRAQRISEQQRLAQMQHAQGGPGAPGQGANGSQQSPPLNMRNGVNGINGANAMNQQNFINNAQAMMAQFNSGNLGSPQANGLHMPAGPAGSIAPRPQAQLPPSIAAQLAQLEAQFRTKNPTLPPDQIRQMATEHLTRLMMAQRTAMNSAAGTANGQGGLAASIAATTSPHQYAALLRQQQQQQASQAAGSPGQQHQQLHQQHQQAKQQQPQQQQPQQQQQGQAQAQAQAQQQQQQQQRQASGSATPSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGE3</accession>
    <name>S0EGE3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_12793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434975.1">
        <property type="nucleotide sequence ID" value="XM_023582441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGE3"/>
    <dbReference type="GeneID" id="35406249"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12793"/>
    <dbReference type="HOGENOM" id="CLU_1482064_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="194" mass="22119" checksum="8F48653EEB7192AE" modified="2013-09-18" version="1">MSFYQTTSNYGATTRSSSMNEAIVNISDSESTTSTGSEDTGSLGEEPATKEQLTYWRLSSIGKGDSYSLKTIGNTSYALVRSIHSVWFTAEWDDGAESWEPEVSLQGYQPELVYAYWDAIEGGRQGATKFDLFHVFRILEHRTMRDSSRRRAKKLCYKVQWVGYDVKDYSWEPAAKVALLVPWMKKEYDKMHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGJ7</accession>
    <name>S0EGJ7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436209.1">
        <property type="nucleotide sequence ID" value="XM_023568747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGJ7"/>
    <dbReference type="GeneID" id="35402828"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09359"/>
    <dbReference type="HOGENOM" id="CLU_524809_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="60362" checksum="6DCA794843267979" modified="2013-09-18" version="1">MYRDGTRNIRARSSRDMPPLSIPKKRKPKMPKEPSRFLACPVEIQLQVLESVPKVGLVALSRVNKQLASIAQPALHRDVDVNCPSLNPGWRSIPLVLVLRTLLWRPDLAQAVQHLRFDGYDFVERELNELPTTPIFHLTDEDKLRAVQFIKALDLYQGLDWAHAFLKGQIDSLVSLVVALTPNVRSLYLGEFFSIEICYLRLLLRPESYNNPRGSNVHKFEHLRHVTVDNHCATYHHIHFSFNNIYQSFFHLRMLENLSISGSFPEASRPFTITAKLEHLRCLNLKRISEEELGRILSLAPNLDDLKYTYGCYPLADLFSTNSQRLDVATLGDSLKSHRLKLKSLQLLVVDNINVLDEGLDPLWPLALQGSPLKLHDFSNLRILTVPWILIAGLSKREHPSPLRYLIPKYVERLTLTDDLYQQPYWGWSGKEIQALLEEYLYDVKETKLALAAMLLVGPILSKMYKNDKFHSARRLARSASVDLKAVETTIPESDVLRGAEERARRYGQLREPVRAEVFDLLDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGQ5</accession>
    <name>S0EGQ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable CTP1-Mitochondrial citrate transporter-member of the mitochondrial carrier (MCF) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_09195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436047.1">
        <property type="nucleotide sequence ID" value="XM_023568931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGQ5"/>
    <dbReference type="STRING" id="1279085.S0EGQ5"/>
    <dbReference type="GeneID" id="35402664"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09195"/>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF3">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="31"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="130"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="225"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT73969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="313" mass="32530" checksum="2CC9AE6560A985FD" modified="2013-09-18" version="1">MDAIATTQPITKPALPKQAVAQTTPAQKKKITPGISLAAGAVAGGVEATITYPFEWAKTVAQLSARQAPAGVAVSKSPFAVIGQTVRSDGIRAIYTGCSSLIAGTAAKAGVRFLSFDAVKAQLADANGKHSAGSNILAGMIAGAVESVTVVTPTERIKTALIDDARSGNKRLNGGFHALRTIAVERGVREIYRGLMSTTLKQSATSGVRMGSYNILKDTFKSDGKNPFMTFGIGASAGVITVYATQPFDTIKTRSQSAKGIGMGEAVQQVLRDGGVRAFWSGSTMRLGRLILSGGIVFTAYENIAGLLMGMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH47</accession>
    <name>S0EH47_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl-CoA hydratase domain-containing protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_08195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play a role in fatty acid biosynthesis and insulin sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433787.1">
        <property type="nucleotide sequence ID" value="XM_023581133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH47"/>
    <dbReference type="STRING" id="1279085.S0EH47"/>
    <dbReference type="GeneID" id="35401671"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08195"/>
    <dbReference type="HOGENOM" id="CLU_009834_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052377">
        <property type="entry name" value="Mitochondrial_ECH-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602:SF1">
        <property type="entry name" value="ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT71708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="392" mass="42546" checksum="EFC357D0FA81A7F1" modified="2013-09-18" version="1">MPFPKLPPRAAYIKLSNPTKRNALSIPVLRDLKSQLDSALALRPTSRTGMLPKFSQQALNELEWALKGPKSKHWERWGWLVSASEWKKQRAGAPDVLVLRSEGPVFSSGHDLKELSEMSRDDVRTLFELCADVMRTIRRSPVPVVCPIQGIATAAGFQLAMSTDFPIALPDTQFALPGAKIGLPCTSPSTAVSRRLPAATTYRLLATAEPIKASDHPDVIDVVKVSPGQDLEEAFEKRVLDVVERLLSMSPQQQAVGKWAYWTQFEFGKSNGDGYEQASLWAARVMALHAKSEDAKEGVAAFLEKREPVWISSGEVEETAAEVVTPETDAPVTQADTAVDVVAPAAEVANPVTEDVASSTEADATATGAGESTAESQMFENDVNHPITTDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH91</accession>
    <name>S0EH91_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_08153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433822.1">
        <property type="nucleotide sequence ID" value="XM_023581179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH91"/>
    <dbReference type="GeneID" id="35401629"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08153"/>
    <dbReference type="HOGENOM" id="CLU_000288_182_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT71743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="311" mass="33959" checksum="DCE2A0FE2A59E58F" modified="2013-09-18" version="1">MAQYGLLEVHKGENAQADIIFLHGLRGDREKAWTKNGVVWPKDLLPDDIPASRIFLFGYDTNITSAGRSGASKTEIHSDAEDVCAKLAAERLSTQTVDRPIILVAHSLGGLVAAQILVHGEHKPENSAEASIARNVRGMIFLGTPFRGSSVAKPAEVVRRVLNLFKVDTQQQTLKLLGVDSERLDELTRAFPEVLNKRRSSKDTNYRIEAFFFYETLKTRWGIGSIQIVETESAQIHGCGDAAPIRADHIDICKFETKDADGYAIVVAAIRKAMIPPDTSPPNGGKVINILGKAINVANDSITIGSQVNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHJ0</accession>
    <name>S0EHJ0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_10537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436559.1">
        <property type="nucleotide sequence ID" value="XM_023569332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHJ0"/>
    <dbReference type="STRING" id="1279085.S0EHJ0"/>
    <dbReference type="GeneID" id="35404001"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10537"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="77"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT74481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="456" mass="51556" checksum="077A28029AB76FF0" modified="2013-09-18" version="1">MRSLAVRHLRTRVSLSSLPSRHLLTFPSGTSLRYTQTTATSSPQVLYLPIEDVESPYGYSPGGYHPIDIGDHLANRYCVVHKLGYGGFSTIWLARDEIASKYVAVKVGIANSDQREVDIIRYLSRQSHGSEHYGKGCILPILDHFCISGPNGTHPCFVTALARCSLRDAQDAADSYMFQLPVARYIAVQMVKAVAYIHSRGLVHGDLHLGNFFLRLPSTLDHLSDKQIYEKFSPPRPELVVRENGQPLPPGVPGHVYWPIWMAEGGNKLTLSESKILLADFGTAFYPHRRPRFGSSTPLDISPPEARFEPITPLSFSADIWSLAHAIWAVMGLKTIFGSFLLSEDDVTQEQVDTLGILPDKWWNKWEARSQWFKEDGSHKKGGCPQRLEGRFESSIQDPRRKCGMEILGEKESHAFKEMIRWMLSYHPGDRPTAEQLLKADWIKYWAIPDFDNIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI85</accession>
    <name>S0EI85_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436804.1">
        <property type="nucleotide sequence ID" value="XM_023569613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI85"/>
    <dbReference type="GeneID" id="35404254"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10790"/>
    <dbReference type="HOGENOM" id="CLU_687053_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="401" mass="45837" checksum="71193C48F3B7265E" modified="2013-09-18" version="1">MDPPVRGTRLVPGKKSFLDLAPELQSMIMESLILSICPLTVPCDAKTKYGPITSAGEQSLLNLKLSCRMIYNAIKEKRFVEAFTIVQPQPHRREWHPSQGAIIFPPSRKAFTIDPFRDMLRVWDMKLPQFQPLSDNILVGRLLSVWCDKPIHHCYSKFDRADYPGDSLQLWRQKFQGRTNPDEPRTRRPDHELSDQDRLIPKLCLGKLAFLRELYIVAKKVPNPPTNDIAPGQHIGEVWNNGASFPPPGPNEYLCPTSGAMVSFESLARPLVGLYGYDKTETTRGGFWAGFLYYQLKKEVWFSPLSALEVRDATTVPVADKPERKLFEGTHSDFVARVWIIRGDQDLPPAQPHHRWVKVKSDQPGDPRYTAEIELMWSIVVDRVLGQTQGETPYELRVHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIJ6</accession>
    <name>S0EIJ6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to GIT1-Glycerophosphoinositol transporter also able to mediate low-affinity phosphate trans</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_10650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436672.1">
        <property type="nucleotide sequence ID" value="XM_023569458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIJ6"/>
    <dbReference type="STRING" id="1279085.S0EIJ6"/>
    <dbReference type="GeneID" id="35404114"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10650"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT74594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="497" mass="54327" checksum="29C1355BE5F4E9AB" modified="2013-09-18" version="1">MLGFGKKREADASDEAPHDEVHTPQDDVPQRPWMETALPVFACGAGLFSDGYINNVIGSVNTTLKRQYGDVYANSNAFKYVSDIAFAGTVVGQLVFGFLADHWSRTNTLMVSTVILIIFTALAAGSYWHGQAVGMFNMLTAWRFFVGIGIGGEYPAGSVGCAESSGQMKKGTRNRWFILFTNSMIDFGFVIGAFVPYVVAAACRNGHYSTIWRTSLGIGVVFPLVLFVLRLRLKEPEEFAKESMRRQTPYSLVLRYYWFRLLCVSLVWFLYNFSSYAFGIYSSSILAGIYGDGANLTTVFGWNTVINMFYLPGTLIGAFVSDWIGPRYTLILGVTLQAIVGFIMAGVYDKISTQIAAFAVVFGIFQALGELGPGNNIGLLAAKTCATGVRGRYYGIAAAVGKIGAFVGTYVFPYIQAAGGNKTESAQYPFWVSSSLCILSALIVFFCIPHVGQDTITVEDQKFREYLQANGYDTAQMGFDSVGIEGGEVNVTKTDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIK6</accession>
    <name>S0EIK6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434291.1">
        <property type="nucleotide sequence ID" value="XM_023581621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIK6"/>
    <dbReference type="GeneID" id="35407234"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13780"/>
    <dbReference type="HOGENOM" id="CLU_631672_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="414" mass="46418" checksum="E9E8A9F45C4E394D" modified="2013-09-18" version="1">MSVRARNALRGSRALLRPPSHAPYRTMIKKEPEQMQKPKGKRTTRPWPSGVMLPAAKVARPIPADPSAKYAIIQIPNTSTAFSEWPTLNKFKPALQPRTSGTIPPGTSAGVQATVDPDMEMAILPYLYNDLGVLIFEGPQWEQVRIMSNILQSVECEECRLPKRDWTMGSALFEVKYDKWNVYRIKLNPRKHIETTYQKGRKKHSITPNGLYSLTNIALEKWEADGIGGPVPLKTVPGSIEMHIVNHIDGPGLANDTINGSYLPQLHAYVATGIRDSTIYMSIEFHTVGTRRLVGVTNLKLRPTFEIPSAKGTAKEPPQGVDRHTDFDQKSASVEGQMKAGRKGDTYSIKQALQPPPTHASSIESLRELYDKLVPSGTHRNSEIYRRAMFKVYELEFKLWAQRKRNIGKEGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIW6</accession>
    <name>S0EIW6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to protoporphyrinogen oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437029.1">
        <property type="nucleotide sequence ID" value="XM_023569876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIW6"/>
    <dbReference type="GeneID" id="35404489"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11025"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="273" mass="30108" checksum="EC001C0862BD7E57" modified="2013-09-18" version="1">MTIYVITGISRGLGYELARQLSNDHRNTVVGIVRDKTATITKISQDAELNRRSNIHVIEADLTNYNALKKAVNETAKITGGSIDYLIANAAYVSKFDTFDPMGALGNTPKELEDDLKMLFDVNVVANIHLFNLFIPLILKGKEKKVVAISTGLADLEFTNNFEHEFTPLYSISKAAMNMAVAKFNAQYKKEGVLFMSVCPGMVDVGQFNHATPQQMEAMGGMMAKFKEYAPHFTGPATAEDAVKDMRAVWENATIEGGYGGAYLSQFGNKQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ70</accession>
    <name>S0EJ70_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to cellobiose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_10731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436748.1">
        <property type="nucleotide sequence ID" value="XM_023569548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ70"/>
    <dbReference type="STRING" id="1279085.S0EJ70"/>
    <dbReference type="GeneID" id="35404195"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10731"/>
    <dbReference type="HOGENOM" id="CLU_011025_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485319" evidence="4">
        <location>
            <begin position="20"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="761"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="776"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT74670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="793" mass="84074" checksum="5C1E1AFE6332E1A5" modified="2013-09-18" version="1">MRFSTLLSSAALMYQAVSAESVEYKDADTGITFQQYTDKSSKFSFGIALPKNPSTDFIGQMTVPISEGYGSVGMGSTMTKKLLVVAWPNDGKVITSVRQADGYTNPAVLDDDTVSIKPIEKGTKVGTDSFTFTFLCEGCIKTDGTTFKAADTNAVLSFAMSTIALDDPTDAAGALNYHGAGFGGYSLDTAAAQSADFETWAKLASDATTPVTSPGGSTGSNPGNFTTIVSNATYDYIVVGGGTAGLIVAERLVESKKSVLLLEQGKASFYESGGRSTMDWNDTVTQYDVPSMAYYLTTAKDTSAYCTDTASMAGCILGGSSVINAMMFVRPQPADFDDKWPTGWKWQDVESSANKLYERTPGTTSPTKDGKRVDQGAWNVLSKFFSSNGFTEVDAIEEPSKKKSVFTHPPLMVNDGLRAGPVRDYLPLAQANNNFKLQLNTKVLRVIREGKAVTGIEVQSGPSTRQIINLKANGAVVLAAGSLATPRLLVNSGIGPSEQIEAVASGSQRLTMPAKDQWLDLPVGENLKDHPIFTVKMKTKQPMSALTETDFTKPSQTNIDLFAQGDGLLAQSGQRFIFWDTVKGSDGVERYVQGTCAAAGDDAVKVKVYLTHGATSSGSLTVTSSGATKLVGEPYLKTAGDKEAVKSFMNKLISFASKPNSTLSIASNATAESLMAEYVSGSHFVGSAIMGTENDGTSVVDTDTKVWGTENLFVVDGSIHPDLPTGNTQAIIMVAAEHAASKILGGGNGTSSPVVPSNGTVPVATTPISTPVATKRPSKCKRSMRQRRHHRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJG1</accession>
    <name>S0EJG1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_10998</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437002.1">
        <property type="nucleotide sequence ID" value="XM_023569845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJG1"/>
    <dbReference type="STRING" id="1279085.S0EJG1"/>
    <dbReference type="GeneID" id="35404462"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10998"/>
    <dbReference type="HOGENOM" id="CLU_012066_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485697" evidence="2">
        <location>
            <begin position="19"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="4">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="154"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT74924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="666" mass="77344" checksum="F49CA1B30CA1F8B4" modified="2013-09-18" version="1">MRFFPLLLLQLQLGLLYACLVADQPKLFLPRSSMTMATPTHVYPGVSLPLRDMPKRSFNRKDEYLFYPIGFPEYKRNQSQVMPVKEVAMMILMDTLTDKPDWHKKVFDETIVQKWRNEVRQQSEDGLYARIMQDKLEKGPRKPRDRIITDTAFDYARYFEKSGLIPTLDGPGNTIIKSDSFIDKSLHRDISRACYTLLKDQEGKTDWHPRSNDMVQNLIHPSMHNFVYDRSPFIQHEVVGVSNALDFMGEGKPVRGQPPVVRQNLFEHVWEPEFAIGSGKIGSEYWADKYQWLPANVRFREDGSAESTSYVNNLHTTKFPEIYRTIEKLVDKAIPAWDHCLREVNRFNDGTDGNDDLWTPKFNGDEFLHKDVELTHQELRDLEEGCYHESEDSVEFDENEDQRRMNEGLPPLTPNVDDETMAEVKWLKYRDAILSDPKPFEEVDYAPKQSLREKFKKEGLQIIVKMASIELTPEKPEFPAGSWHIEGQMNEKIAATALYYFDGENVAPSRLSFRMQRSSYLNDEIKAGQDRYNYLERVFGTDLGMQGGLARSCVQSYGDVDTPEGRLLAFPNVFQHRVSSFKLEDPAKPGHRRFIALWLVDPHRRILSMANVPPQQKDWWTGSGEVPSGLMDIEEARAHRLKLMDERTAEKARAHWESIDYNFCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKR1</accession>
    <name>S0EKR1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to aflatoxin efflux pump AFLT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_11237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437273.1">
        <property type="nucleotide sequence ID" value="XM_023570113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKR1"/>
    <dbReference type="GeneID" id="35404700"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11237"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="550" mass="58630" checksum="3B37B5B848D65D84" modified="2013-09-18" version="1">MASEVLTERPLASTGASEVNGDSTAQSRPTSTLEIEEPRDDEENIVYPTGPKLWSTMASMAIACFLSGLDLTIVAVAVPSITDEFQTIADIGWYSAAYGMTLSAFVFFFGQIYTLFSIKAVFLIGIATFEIGSLICTLAPSSAIFILGRAVSGLGRGAINGGLFKLLRQCFPLSKQAITNSFFGSIQSVGLITAPTIGGALIDAFSWRACFGVNLPLGVMCLVLTAYGVHEQPPRHEAPVLTLKEKVKKVDYFGTLLAVPAITFLLMALQWGGTKFGWGTWQIIVPLVVCALLFVAFGYLQYRQGDNALLPPRILKQRSIIAGMWYGACCEGVLAVTEYYMSIYFQGVRGYSPTKAGLLALPMVGGLAIAFIISGVGTTWIGYYYPFMLATSVLTPIASGLLTTLDLEEQIAKAVGLLTFLGLAVGLGLQGPQVALQAVLPIEDVSLGGAVITFGSGMGSALWICASATLFQDRLSKEVQDAAPGTNTTHIEEAGLSKLRESIGPDRLKSVLSGYENAIVQTLYIPLALALLSIIGAVAMERKSIKKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL87</accession>
    <name>S0EL87_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437849.1">
        <property type="nucleotide sequence ID" value="XM_023570788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL87"/>
    <dbReference type="GeneID" id="35405304"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11843"/>
    <dbReference type="HOGENOM" id="CLU_008751_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1074" mass="120771" checksum="B5A47EE890BE1A71" modified="2013-09-18" version="1">MAEAFGIAGSAFGTVSLGVQLFKEISQYLDDIDGREEDLKDALSYATNLQLSLNALNVAMSNAPTGDPETKNAIDSCIVSCVSAVNNLLAVVKGLRGPMVSAPSSKASKELCAKLKYPFKKQNMEKLEEILSRTNSALQTILQVFQLNNSHATTAAINDVHQAMANVNLISNNNKSTLDEIQKTSELHNDRLSTLQRDVRELLILTRDSQDSNILLRTLAQHMSDHTSHTSVTANLLQNPTSDTFLPSVQTTSYQGGYNMTFDAFCSCKTQRSLFSQNRWGPFLLEVEIRSRDRHAPECPMSKLSAATHQTKRVLNLSLPKSLKLPGRASRFSLSFTTGAGILGLSQKLAWVATVDEDSSPVFRIVRMMEKYNRLPRKDMRILLASCLRRLIWCYVNSHASVTDVNKNGDSIIEWALEHYQLSSSLAALNADNMADLFQMLSVVTKPATYPRRVTVTPIPALLARSNWFSKCTRPNQVATALLSNYNESVGHCHRDWALSWWRGNGFVRGSYTLFQSFPQVAENLEFGPLSQAILKQDRDGVQQLLKTYPSYINEINYCGQSPIHLAIETQNMDIIGVILLYANIEALKVKDNMGRNPIALATAAIGTHTEKIQESCGGFKVLETLIRLETAILPSSLQLGFMPSRNHGNNCTHGHKILIKGLAQRREALKELAYRKLSPSERQHLEIHQARILDKNAARVQYQLEAQGCAIPTHLNVYEANAESSVAQTSIYTYICSGEVAEFARQLGFHYSNNELADYISTLATRMGTEDCHTYIYTPFSCSYFCWMIDQGTNVSTRVHNKQLPALETELTIAHYFMASHGMMIRGDRGFTLDCSISLEAFKIVFSNMIVDRCRCWCSPGGCTPLMKLLSGIHWFEKSPRFFSEGNFIDRLIRATESRITGLFSIYTSEISQYQWIYMAIVRYYTFALLELPHVCCCIIQNPSGPLPEDERRELQEEESFLLELFENLIAEFEEKCLHEMRLEGFFEWMRLVWVPRMCQAEQELASLSLTSQQLQDAKAIGVVLEFDGPLPVDPSPRVVEGLEDDLWDAMDELDQIATDPERPMKESLQTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELB7</accession>
    <name>S0ELB7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AttH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436775.1">
        <property type="nucleotide sequence ID" value="XM_023569579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELB7"/>
    <dbReference type="STRING" id="1279085.S0ELB7"/>
    <dbReference type="GeneID" id="35404223"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10759"/>
    <dbReference type="HOGENOM" id="CLU_041422_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38037" checksum="A436C4AA7719FEA2" modified="2013-09-18" version="1">MNRSWIRRYINAKGLGVESGEWEWWYADTHLQDGWFRQVPFFYITEGDGPKTGLIDLNIAKDGKKLCDLHKRIGNLPSEIVVAKDRCDLQYRKNYFRSINGLSKYHIFVDPDEMEGFGFDVVIKRNTPSHRPGSGRWDMEGRHFSWFVAVPGGQLTGEVTANGTKTKVEGNAHHDHNWGNVPMETILDNWLWGRADVGGLSIVSASVRFRQDCGGREVPLLFVVRENEVLVDVSDNQLVCLEGVKIAQPDTGKPTSSDCIYLVKSTGDNFAQVRFDGQQKVIASFPYPTTSQEWETRYTRYAGMVTINITDGDKRVYVSDHGSLEVMDFFGRKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM19</accession>
    <name>S0EM19_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to phenol 2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435521.1">
        <property type="nucleotide sequence ID" value="XM_023568300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM19"/>
    <dbReference type="STRING" id="1279085.S0EM19"/>
    <dbReference type="GeneID" id="35403229"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09762"/>
    <dbReference type="HOGENOM" id="CLU_009665_9_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF7">
        <property type="entry name" value="P-HYDROXYBENZOATE-M-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="422"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="639" mass="71503" checksum="D20491DBD336BDAA" modified="2013-09-18" version="1">MSQSQSDRSPYYDIVIVGAGPVGLMLATCLARWGYKIKHIDNRAEPTPTGRADGIQPRSLDLLRNMGLKSAIMAHHPARVYEVAFWDPASSGKGIARTGTWASCPDFIDARYPFTTLLHQGLIERVFISDLEKNGAQVQRPWTIKGFTSDEKSNPAYPVTVELEHVDGTAQETIHAKYLFGGEGARSFIRNQLGIAVHHKDPIAHVWGVMDGVVKTDFPDIKMKCTIHSEHGSIMVIPREDNMVRLYIQIASSTDPDWNPRRTATEEQVQESAKKILQPYSIEWERVEWYSVYPIGQGISERYTLDQRVFLGGDACHTHSPKAGQGMNTAFLDAQNLAWKIHAVESGFASREVLKTYETERKHVAESLLDFDNRYAKLFSQRPPAAAEVQAASANHGKNDVQDNEFINAFKESCEFTSGYGVYYKPNVFNWSPEHNAQSPLIHPKGTKLRTGRLLINSNVTRVVDANVVHLEQEVPLNGAFRLFVFAGVPSKTRQALKDFANHLGSQRSFYAAYQRPDLDKVSYHEKHLPHSRFFTISTIFSSKRPEIEISRDVPGVLARYRDHVYADDRSDARFPRAKAVAHAKMGLDEELGGVVVVRPDGYVAIVVSLVEGSGTVDALNEYFSTFCTKKLGPTLAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMD9</accession>
    <name>S0EMD9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to bifunctional 4-hydroxyphenylacetate degradation enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437125.1">
        <property type="nucleotide sequence ID" value="XM_023569990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMD9"/>
    <dbReference type="STRING" id="1279085.S0EMD9"/>
    <dbReference type="GeneID" id="35404590"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11126"/>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF86">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G07000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="283" mass="30552" checksum="4F2607B0EB57C191" modified="2013-09-18" version="1">MANFSVLIKFESEEDGETYFADLGSDAQGPPALGTKVAAVKSLQGLADKHKPKTVTIRRLLAPLPRDDLPLYCVGLNYRSHAKEASLTLTSVPPLWTKPAASLANPDEDIPLNDFCAKSLPDYEGELVFVTSKQCRNISPKEAKDYILGYTVGNDISCRMYQLPKHSAGQFFFAKAFDKFAPIGPALISPAVFGDGSGFSVEAKVNGEVRQVAEFKKDMVFSPEQILSHMSQGTTIPAGTAVMTGTPAGVGAFRSPKVFLKDGDVLEVTMARAGTLRNVIKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMT8</accession>
    <name>S0EMT8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_11274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437305.1">
        <property type="nucleotide sequence ID" value="XM_023570154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMT8"/>
    <dbReference type="STRING" id="1279085.S0EMT8"/>
    <dbReference type="GeneID" id="35404736"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11274"/>
    <dbReference type="HOGENOM" id="CLU_004835_2_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT75249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="535" mass="60307" checksum="81F63D2329E1E952" modified="2013-09-18" version="1">MQSQAHIQDDASRPSKRTRLDPQPNATGRDAQPTRRRVAVACKVCRSRKTKCDSRWPVCSYCEKSNSECRYDTVDSADRPLSHDLGMQILQAVQDLAQDVKEQRSSGMANTPSQAHQPTRHSEADSLANLTATPQSIPAPEGHVERFSEGLDSVLKWNVFPSDIDLIPVDNGSLMAMPDELPPISFPELKRLQKCYLSTVHSVNPILDVAVLDHIWFMCNLQPLEAWRYFTMAGNSCYSAIWAREPAIPAEPQNLPSSPQAIKQSIFYTAYKSEVEIRYEIPSLPGSMLEHIEDRLTFPSPPAANCLFDETIAWYYFLADIAARHLINRIVDAKVEISGCPTEAQANSLLRSYEVFGSQLQDWYLSLPPEISFPPPDATISSESNIYKRILRSRYLFIKELLCRPFVRLCLNYDLKLPSALDDEIVSIASLGLQYCAWRLKAVDRMNKLDHGLWIWIRNSTACSMILIGAARSLQFQSGTASRRIVLPKSWRETVVSFLHGLEKYSHETRGGVASCYRLVTWGLDGFHPSSPDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENJ7</accession>
    <name>S0ENJ7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable GTP-binding protein Drab11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436236.1">
        <property type="nucleotide sequence ID" value="XM_023568269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENJ7"/>
    <dbReference type="STRING" id="1279085.S0ENJ7"/>
    <dbReference type="GeneID" id="35403257"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09790"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT74158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="212" mass="23263" checksum="B1F31D52841036E5" modified="2013-09-18" version="1">MANDEYDFLFKVVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQVDSKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKHQTYENVTRWLKELRDHADANIVIMLVGNKSDLRHLRAVPTEEAKSFASENHLSFIETSALDASNVELAFQNILTEIYRIVSSKALDSGDSAQATIGAGTNISLSKPADDDAAKGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENL6</accession>
    <name>S0ENL6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436281.1">
        <property type="nucleotide sequence ID" value="XM_023569006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENL6"/>
    <dbReference type="STRING" id="1279085.S0ENL6"/>
    <dbReference type="GeneID" id="35403710"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10245"/>
    <dbReference type="HOGENOM" id="CLU_025462_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="388" mass="44876" checksum="0281350505D0E45C" modified="2013-09-18" version="1">MADLYFWYSALLTALSVTLVWWRNKKQYDPKPYSPQDSQHHHEELPSDYNDIEPLEDFDLDNAEPVQTRPWKPKYHLTMGLEKCTFSDILPIDKTLEERLALRRKIVTEHSDMVIASDPCSEAAVKEFYIWMVRTYLPRRYPSLYHSKGDTLLGPASTKLPLDPPNDVKAVLRLLAENMDTELFFLQRQGDSYVARALIDCYPFSFNPSLKLNKTLAEIHGPVPGYKEKLERPMNRYFTSLPKGKAVKRHNWNISIGRDLFAPRENPLTVLPLWLMDRIKTVLDWLGIEVLTMKGADLDPEEMNVRCERQTLHRLMENDNTLVFAFKTYQYPLRQIREEGGGPALAEAIRGINRGSVPQVAWYKASVYWERAVVEYLLGGSSEQPGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENM1</accession>
    <name>S0ENM1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_11718</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437730.1">
        <property type="nucleotide sequence ID" value="XM_023570649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENM1"/>
    <dbReference type="STRING" id="1279085.S0ENM1"/>
    <dbReference type="GeneID" id="35405179"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11718"/>
    <dbReference type="HOGENOM" id="CLU_030571_4_0_1"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT75684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="263" mass="29160" checksum="6D363592BA483E47" modified="2013-09-18" version="1">MFIQPIPMWWGSNDNWAYLVVDDESRDALIIDPANPEEVIPVLIAAIQSNKLNLVAVVNTHHHWDHAGGNEEILAALGNPKLDIIGGKDCKGVTKTPGHGETFKLRNITITSIHTPCHTQDSICFFFQDGDQRAVFTGDTLFTGGCGRFFEGTAEEMHVALNKHLASLPDDTVVFPGHEYTGSNAKFAISVSHSEPVQQLLSFSDANPVTVGKYTIGHEKQHNVFMRLDDPDIQRATGETDPVSVMEKLREMKNEYKEPEPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENW8</accession>
    <name>S0ENW8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to TRI13-cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438000.1">
        <property type="nucleotide sequence ID" value="XM_023570968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENW8"/>
    <dbReference type="STRING" id="1279085.S0ENW8"/>
    <dbReference type="GeneID" id="35405466"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12006"/>
    <dbReference type="HOGENOM" id="CLU_025001_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT75954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="579" mass="65338" checksum="5F9582C41F108353" modified="2013-09-18" version="1">MFSPSPQALGIVVAVFILATLLIRRALLPKPIPGIVYREANAKKILGNAWELLQWKKKHGEMFGYLANLAVELNEPVFQIFVHPLGKPWVIVADNREAFDILSRRTPKEFDRSRFLRSLFMPLVPEFHFHMPTGDRWKAHRKLVADTMSPAFLGGVAGPQMWKSTMKLIDLWRVKERLAKGRPFSVSTDIRKAAFEIIWAATFGFDSGSTNAQTELLETLPEFTNLGDMDHEVEFPVAPDPPVFKAGLALNDAMNIGVQSLVPGLHLWLAYNLMPSLRAARSLKEAVIQDEIKKAINKFSNQTDLNWEDQGNLKRHMKSAVDIVIAREIDSARKEGRTPELMSRTVQDELFSFMLAGNEIFTLTAWTLKFLTTHQNVQKKVRDELREECGAAVERGGAPTVSEIMSARLPYFEAMIEESTRCGSVTQTNIRTTMQEVNILGHMVPKHTEILMLNNGPGSFMPPLTVDEEKRSESSKGTAGKIGQWNVKGMRDFDPERWLVKDEEGRLTFNPNAGPRHSFGAGPRACFGRKWAALEVKIMMALIVWHFNLEPTPKPLSSFKPFPGVAHRPEMIYLRLSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP59</accession>
    <name>S0EP59_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to isoamyl alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_10739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436756.1">
        <property type="nucleotide sequence ID" value="XM_023569557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP59"/>
    <dbReference type="STRING" id="1279085.S0EP59"/>
    <dbReference type="GeneID" id="35404203"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10739"/>
    <dbReference type="HOGENOM" id="CLU_018354_4_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496219" evidence="3">
        <location>
            <begin position="20"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="187"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT74678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="654" mass="71887" checksum="9FF8905B63AE9853" modified="2013-09-18" version="1">MQGSHISWLIAALVPFTLAQTIEVDGKTVPANKNNVAPAWSEPPAASSRYSFVDDTPRLTDAVLTNLTDLNLSDVDLFYFADTKGSKKRSAAVDSKCKVFPGDKLYPNKLIWKVFDLLSGGALISTVPLGSACYKGEHYNKEKCAFLLSNWHNSTTHIDDPTSVMSPLFEGATCEPENAASGSKCTIGGFPLYSIKATCVAHIQLAVNFARNLNLRLVVHNTGHDFLGKSTGAGALSIWTHHLKDIKFTKNYRGASSYTGPAFKIGAGIQVKDLYLAADQQGYTAVGGECRDVGVAGGYLPGGGHSPISPIAGLAADQLLSVDIVTPDGRFVTADEKQNTDLFWAVRGGGAATWGVVVSMTVRVYPKMKFSGMTWSVNTKDAGISQEALFKALDVYWRRFPEYSDKNSYGYSFMFPAGNGSFLWTMNPWMIPNISVGEFKKIVQPLLDEWKELGVDPKPTFFEHDRFYPAWKTHFPAENVGNYNGRSGSRLIPRKNWNDPKLLNNTIDVLKGILADEGILIIYNINAKQQNTPPNSANPAWRDANMFVITALNWNYTDSEEEIAKVNNELTHGVMERLKAVTPGGGGYGNEGDVMDPDFGQSYFGSNYAKLYQLKQKIDPYGVFYAPTAVGSEDWYITDHPAYVIKQTGRLCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP94</accession>
    <name>S0EP94_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Pectin methylesterase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_10842</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436851.1">
        <property type="nucleotide sequence ID" value="XM_023569671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP94"/>
    <dbReference type="STRING" id="1279085.S0EP94"/>
    <dbReference type="GeneID" id="35404306"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10842"/>
    <dbReference type="HOGENOM" id="CLU_012243_1_2_1"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF57">
        <property type="entry name" value="PECTINESTERASE 53-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011119905" description="pectinesterase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="8">
        <location>
            <begin position="54"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT74773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="323" mass="34605" checksum="C54BE7E45D97B3CD" modified="2013-09-18" version="1">MPFPKSIFHLVQLALLFGGSASSVEAASLSNRADNSRTVAPANCIVVRPSGTSASEFTSLQAAVNSIGSSTKPACIFLNSGTYNERVEIKVKAPLTLYGATADTGSYKKNTVVIKNTTGSQDAGSSVASSTVNLRSNDFAAYNIDFVNGYTAGQAVALTANGNKTGFYGCSFKSYQDTLYVKAGWMYYSNCYIEGKAIPLLTRLGILADNSTIASKGPGYITASSRTEPTDTSRYIIDHSIRVIARVMYQYSTLTNVVRPEGYSPMAEGATLSKAKFVSVFQEFGNTGAGADTSQRKYFTPSDKALTKQDLCGADFKWYDTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPJ1</accession>
    <name>S0EPJ1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to cytosine deaminase and related metal-dependent hydrolases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437286.1">
        <property type="nucleotide sequence ID" value="XM_023570128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPJ1"/>
    <dbReference type="STRING" id="1279085.S0EPJ1"/>
    <dbReference type="GeneID" id="35404714"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11252"/>
    <dbReference type="HOGENOM" id="CLU_012358_11_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="57"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="504" mass="54830" checksum="56666AE36B7C6FC0" modified="2013-09-18" version="1">MASRLLLQNGTVLQHDAQDNVIALKNTDILIEDDRIMEIGQAIEPQNASKIDCDGKIIAPGFINAHHHVWQSQLKGRLGNSTMLDYMLEANFQSFNFKPQDFFWGQLAGCLEALDAGTTCVVDNAHGASSPEHGTAALSATLASGIRSIFCHGVMPLRAVEWTESSFELDRSPQPDWLLPQMDYLAAKAPFGDDKRVQLGFFFDSHFLPENVIAETLTHVKEAGVKLIVSHYRHWPVSKGQSRVPEQLHASGLLGPDILLTHGNGTTPEQASLLTEAGTYIVSTPDAEIFMASGADPVAFREDLPLMCLGADCHSCGPVSMMHQMQIALASDRGSQNSKTFAEGHYPKKMRATVQKAFNLATIKAARAINMDKDIGSIAVGKLADLVIFDTTSPSISSAADHDPVTAIVRHAGVREVETVIVGGKVRKHDGSLQNVHLAEGRDAGFDLKLEAVDSKDVLSWKEVAKELARSRSEIESRINKVNKELAKEKLIGMMGGLKDILVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPQ0</accession>
    <name>S0EPQ0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437581.1">
        <property type="nucleotide sequence ID" value="XM_023570473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPQ0"/>
    <dbReference type="STRING" id="1279085.S0EPQ0"/>
    <dbReference type="GeneID" id="35405023"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11561"/>
    <dbReference type="HOGENOM" id="CLU_059226_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="150"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="395" mass="44471" checksum="F62AE7CC503FC046" modified="2013-09-18" version="1">MPAQDTSDLISQQVASWLNTTSYAASLLEPQAGGQANFTYRAHLINPLDDGTTEVVVKHGEPYMARHPANAITVNRCDVEGEILSELSTNPIDVMQSGNTGYAVRTAAAYAYDTKTKTLVLEYLPNVVDLKTYSLNHFPSPTPEYLRNPTRELGKALAIYMVKFHDMTREIIQKWFEQKHTQQLLGFNRVIDSSSDMQKLKHGINFDWMIDRVDQFPRILSEAKDILHLVKNMALKELSDPSVDLTLIHGDYYPQNILLENVHLESATTRTLYVIDWENSQVGVPSLDHGGILGEMYVLWKYKHIDARLWMLQGYAEGLGPRTEDAAWRVALQVGVHLLSFGTLASGLGTTEEVEDMARLARDVIVKAWTRDRTWFGKSDFACLFAGTTQDPGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ39</accession>
    <name>S0EQ39_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to ariadne-2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_14136</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438276.1">
        <property type="nucleotide sequence ID" value="XM_023571227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ39"/>
    <dbReference type="STRING" id="1279085.S0EQ39"/>
    <dbReference type="GeneID" id="35407588"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14136"/>
    <dbReference type="HOGENOM" id="CLU_004235_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22585">
        <property type="entry name" value="Rcat_RBR_DEAH12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="569"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT76230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="782" mass="87195" checksum="FBC76432DCFDE716" modified="2013-09-18" version="1">MGNIFGRETEASPPPRELPPVLAATRQPLYHGRDLPYEDPFQNREVPQIQGPRPCVFYARGACFRGTACRFSHEGAVDTSSTKKSQKPCRFFMRGHCRRGEACNFSHEQSSVQEATKAIKDDDCAESWVRELGGAWVKFGDGAAIIDVSLPSDFSAIQIRNLPTTASAYFIRDLLSEVGIPVLISDIRYIKPKDMPNGFATVKVKDPEFAKTACSRLQTVIEPPGLEVSSMRVPIPPGFHFGQVDNRQVRCSWHRPTRTSSLYFTNRKAASRSFYKFKCEQYKINGMKATVQSLIAEHPGQQNGRWKIDLVGMSASITEDDIASAFPSFEKPCSITIGDLSYEMDIEMDSTLVKSMLYEKGELEKWNVSDSSTAKRIKAQATFMEECHAQAAASSLDGTELPFNHTGKLFVQLITSVKFKVSARVYDAVKKTIDSHKSNWNRQFIRYSALPERGFNRILKIEGEDRQLVAQAKRDLEKVITGTVLTMDGKNIWYSNLKISKNAYKKLQKIERDLEVVIIRDIRASNFRAFGPEGRLAQAAEALQQLINELKSGDHAIKKAVSTVKRQQLEPDCPICFEEAEESLETSCGHIYCSLCFFNMCQAEASTSGDFSIGCMGNSGTCGKIIQISELQTLILSETFENILEASFASFIRRHPAEFRYCPTPDCDQVYRVSSPGKLPSTFTCARCFTPTCTACHDSHLGISCAKHKGNGSEDIEELIKAKEDLGAKDCPKCTTALQKAEGCNHMTCLACGTHICWVCMATFTEGSDCYRHMGQFHGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EQ47</accession>
    <name>S0EQ47_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438316.1">
        <property type="nucleotide sequence ID" value="XM_023571275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EQ47"/>
    <dbReference type="GeneID" id="35407546"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14094"/>
    <dbReference type="HOGENOM" id="CLU_2133641_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT76270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="117" mass="12563" checksum="29DBCF93968701C8" modified="2013-09-18" version="1">MWLPTTADTPKLIDVLRKLGINDSTSDSASTCTIRSYETRYYFARTSPESDSPLDAISIATTSEVDKEIDPSDGLMPGAQAITEDPGFEGKIHLMNGRKVVLTAGSSGTVSQRMSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ50</accession>
    <name>S0DJ50_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424605.1">
        <property type="nucleotide sequence ID" value="XM_023569685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJ50"/>
    <dbReference type="STRING" id="1279085.S0DJ50"/>
    <dbReference type="GeneID" id="35394406"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00921"/>
    <dbReference type="HOGENOM" id="CLU_008309_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1005" mass="112001" checksum="7B1E2A7B5E45BB66" modified="2013-09-18" version="1">MDIVEFYVSCNPPLLPKGVALIFARVEERNDLGIFEILYEPETPWFKLIALRASQHEITNWMHSQLEELMESEADAVIRDEDEDDLGTSVIQPDVEVLVEDPHIIAFPSLQTILKDTLSQYDAFRYPATIKILPYKTLWRVPESSGVTILQILSNYESLGSVLPLGPSIDSLQALTKCVITYNFQGSLLYIGSSESEHALGVAKLKLDTLAAFMHVPLVPTTHMVFTETSSSATLCYRYMTHTGLSGLTYVDSAVIGQSEAMEYSSIGSAASLRIESLNRYRQPAPDRVKYPIPETGKLRDWHPEFRPFSGYSYGNKRSGAIPTIKKKRPQQKIHHQESDSVGKITASTEGHRNLEHIGTDLPQVRKCLEDLRYQARNNKKITNWLCSIEFSGDDDQLKPASFLVGDSGKQGDGIATDLQYGSRPELSRGIEESREPWLVNTKGVPLEEAKIKDQVPGSDYRASLCQLPLGLDMPENSLELPNFPNPSGPQSNAAKDLMDIDDGPITTPALMDNIPLHDDGNKLQTVSEDQVVHSEVTFGKRNHQEKRLFDTMRQKAGSGLSWANVASKKKDEKQDDKPTFGLNVPVAFVPDNRSATQSSTTPTSKVIASLDHIPAKQKEEHAKDKSISVEKPKPDPATPAFRIVPGMVMPTTDHEEYSDFLPEAENKLRKLVEVLQIVPGKVSIQAQFGRLCRKDIFPALVYDGQAPSWAVNKTVEALDTENPHMGFYPILTTSGAEANLIPQMLGGRSPWELTGKRVYYEFHCFAGKTPEVIVEVDADTFQHQHFPPTTEVSKAFVHCTQRAWDIKISVSRMYTQAMADDMEEFAASLVRSMSIGTNEMGELVISTEPKSISNLGVDRVRICHEARYRDGKKGPSCLKVTMIRRVEKLPGIPKGTYRGQSVPVTPPGNGRPGQWFEASISSVRAEEIFQENMGLEFGDKTHWTPDILHQQGVFRAISEPALQMVRKMDHVGDSNSNGQGPRTGQQSYSAAQDSMHRQKGTYFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJG7</accession>
    <name>S0DJG7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_01026</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424507.1">
        <property type="nucleotide sequence ID" value="XM_023568518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJG7"/>
    <dbReference type="STRING" id="1279085.S0DJG7"/>
    <dbReference type="GeneID" id="35394511"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01026"/>
    <dbReference type="HOGENOM" id="CLU_014853_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="187"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT62426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="802" mass="88789" checksum="AB420D55943A6E91" modified="2013-09-18" version="1">MSSLQNGISNSEHPVVETPVAVSTSSLDNANTESEIREALASLHAHEASITSRLDALVASQADLSRDLGRLDLLRAGLGAQVIAARSIGNDMLATAADTAGRLSDRVKELDLEKSRVEETLGVVEQVAELKACVNGVVGSMGAPQDWEAAAGYISRASKVPEEITKGSFAVGIVPSVEVPDPPWVTLEEAKESLCGLFLREFEKAAEESDGTKVTRFFKLFPLIGRAEVGLDVYGRYVCQGVAGTARATLKDAMNGQRREGFFYANALTKLFEHIAQIVEGHGGLVERHYGSGKMVRVIERLQMEADVQGGIIVDTWSDERGIDRKLTDVRSYPFSFLVQSFLPQPPRGGTPRVNSPAIGVGNNPRESEDEGVNMREVDGLLSEIAVMLGRWSLYTRFLAGKCKNPDTPDEAPLVIPDVLVKSNLYRKVSTKLTSPYNVMTTFFFRRSVEKAFQLDEYPSGLSLSLSRQIEGNAPYIILAVDDVMYIVNAVIQKSISTSQRDVIASVVPTVGRVLGSDFVGMIQRKMRDESYPRPVVQGGFPPEDKIIQFIVLINSLDMANEYLTRIITGRIGESSHLPNDNAQNGPLKDSFPFERDVVFVANALHTLQTSFIGKTTELLNEGIQVLFNQVVKLRLRPVLTDTFRDADYTLSEDDIADIAQQNDEDEDELLEQVPRLFEHGWDQLMKPIARLMTPGTYTTLLDTTARYLSKIWEKKIMGYAGRTNALSAIRLERDFIALVDVVSRGDYAVREVFAKVLQILMVANMEDDEWDEVMAQDGEDDAIEWVLTEEERRRARSLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL46</accession>
    <name>S0DL46_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable subtilisin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_00255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425207.1">
        <property type="nucleotide sequence ID" value="XM_023573497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL46"/>
    <dbReference type="STRING" id="1279085.S0DL46"/>
    <dbReference type="GeneID" id="35393740"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00255"/>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000006">
        <property type="entry name" value="Autophagic serine protease Alp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012135847" evidence="9">
        <location>
            <begin position="16"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="11">
        <location>
            <begin position="42"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="191"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT63126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="531" mass="56989" checksum="6F3E3B2BE651313E" modified="2013-09-18" version="1">MKSALTLSMAAVASAASFSVGTVHDKAAPILSSIDAETIPDSYIIKFKDHVDHAAASDHHMWVQDTHKQGETERLELRKRSIPFTDKTFSGLKHTFDIGDAFKGYAGHFDESMIEKVRNHPDVEFIERDTLVHTMVPVSQNMITEDKCDGETERQAPWGLARISHRNTLNFGTFNKYLYSSDGGEGVDAYIVDTGTNVDHVDFEGRAHWGKTIPSGDADEDGNGHGTHCSGTVAGKKYGVAKKANVYAVKVLRSNGSGSMSDVVKGVEFAATSHLEQKKKAKDGKRKGFKGSVANMSLGGGKTQALDAAVNAAVRTGIHFAVAAGNDNADACNYSPAAASEPVTVGASALDDSRAYFSNYGKCTDIFAPGLNIQSTWIGSKYAVNTISGTSMASPHIAGLLAYYLSLQPAEDSEYALASITPKKLKENLISVATEDALSDIPSDTPNLLAWNGGGCSDYKKIVEAGSYKVKAAPSSRVEEIKHAVEQEVNLVSGKLTTGAKELGSKAEKFSKKIHELVDEELEEFLKELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLS4</accession>
    <name>S0DLS4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_01744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425472.1">
        <property type="nucleotide sequence ID" value="XM_023575306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLS4"/>
    <dbReference type="STRING" id="1279085.S0DLS4"/>
    <dbReference type="GeneID" id="35395229"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01744"/>
    <dbReference type="HOGENOM" id="CLU_010891_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="699"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT63391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="766" mass="85043" checksum="14FA23C94FCE08A3" modified="2013-09-18" version="1">MFSEYASRFLAQSQSRLSNFGQADNNDNPPRQSEWPSRTTRNQRETGRGNGPSRSFLGRGYGGNPYQQTGAGSRFGQLAFASRISAAQDAPLFHSTLDEFREEDDEEERDREAADMFALQRSRRVAAASKLADSVESDAHSRGSLEDSLNHEDPYRDMSMRRGIRSSWNGTRSTHRPGLARDTIGEEAEDDTRSSLDRDSSHGTDVKGKMVDVGLESQDDPDEDPPASLLGGQTPRESSPPAFQQFKGTDTERTPFMARRESTTETDASIQRGAPPEEEPIQTTFQYIEGEIFRHDPFFAWIFLISLAGMLSTFFLVWLHTSPRKSPVGDTIYTTLQKSFHMLAVDTVVAVFVSFIWLAALRSFVRPLVSVILIAVPVILFSFSIYSFVSSFKGRWHGSSFQDSVMRWASIIPAVSCILWIWLVVRGRRAIQQAIEILQFSSRILAQNSALLFVGFGCLALIVVWTWAWLAMFTRVFMGGHFSKSMLRFVIQLSSWWLGAAFIFLYMWTVSVINAVHRATTAATVSQWYFHRNAGPATPSREIVSAALNHALTTIFGSLCESTLLSLLIRAPLIFLPRKLGATVTNIASFWIPTPVIALMNPLTITYSAIHSQNLATSARGLDQMELVSPTVPTTTLTPRALRNRGQPNGLLPYRLAKLLLVATRLIMATGLGFAGWVITAKQLRIQLPDGVGVRGSAYAYVVGMMASFIGYSVMGAMEGILSGIVDAVLICYGSERRMERGHGRFCLEAAYLFGERRGGDTLEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLY0</accession>
    <name>S0DLY0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1909-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425527.1">
        <property type="nucleotide sequence ID" value="XM_023571985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLY0"/>
    <dbReference type="GeneID" id="35394199"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00714"/>
    <dbReference type="HOGENOM" id="CLU_181109_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="3">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT63446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8186" checksum="BE8769D4A304FE0A" modified="2013-09-18" version="1">MGNGAKAQQKRERNAKDKNTAKSQLKVNEKACDIQCQICKSTFLKTTKAPALKEHAENKHSKTIADCFPNVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM62</accession>
    <name>S0DM62_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423709.1">
        <property type="nucleotide sequence ID" value="XM_023575339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM62"/>
    <dbReference type="STRING" id="1279085.S0DM62"/>
    <dbReference type="GeneID" id="35395537"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02054"/>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="379" mass="42618" checksum="BC9EB37CC3E6DD4E" modified="2013-09-18" version="1">MAEASIESTSPKAAAASSPPAEATPAPAEETSTEPPTAENPAQPAEDFHNPNHWATLNEEDAPGVDDADSAVGDDVASSTESISSSILHYRTIHGRTYHSERGNAEYWTPNDEHHNESMDINHHLLSLSLEGKLHLAPLKDDIQKVLDIGTGTGIWAIDFADEYPNAEVVGTDISPIQPDWVPPNLKFEIEDCTQEWTYEPNSFDYVHMRYMYGSISDWSALFKEAFRVCKPGGWVESYEASPRMESDDGTVTETCAINEWGKFFIEGGKKLNRTFEILDKDLQQKGMEEAGFVDVKVWDFKAPIGGWPQDPRLKQIGQFAQAALEQDYEGYILYMANMVLGWTKEEVSVYCAQLRREIRSGKFHPFYRQRVVYARKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMD6</accession>
    <name>S0DMD6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425681.1">
        <property type="nucleotide sequence ID" value="XM_023571364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMD6"/>
    <dbReference type="STRING" id="1279085.S0DMD6"/>
    <dbReference type="GeneID" id="35398734"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05253"/>
    <dbReference type="HOGENOM" id="CLU_477378_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="436"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="571" mass="64998" checksum="110819CEA375D704" modified="2013-09-18" version="1">MAETGANHVLPNLHGAQISQILMTDPLNLNDLGFNRYPTLPLGDLPAARVREIYEKIVDEIFSAMSMTRQASPQCWDQCVASLESENVLLATIFTECEAYRTIKDKCMEALNLPRIDEQTPCLPAPVLVSLIATINYRKVSVAKPHNSIIAMLGDHDTAAWLKVAIQVFGTTGQNPFLVSRDDSVHSPTTDQSNGVWTIKATMPLPHRYLALVHRELPRLRAAPELRSDSVKEDESLEEALRRLNRRLVRDIGDAVYTEAPAQFHTITLRITREQALARVGELVRQVRNADFDQEQLKPQMERSIDFHIFSVLPLAVKKKVHSWYRNHSPESNELIQRFASVLLEDITETSWEHKLQGERINMKDSDLAAPSMKLLAKLINSLPKTGGYKLVRGRGIQAFNDIKNIIDYQRSFRDHYTKLMEATQQNRYPNSSLISDEALEQLKETQEQLKNTQEQLKNTQEQLKNTQEQLKNTQEQLKNTQEQLKGTQEQLKGTQEQLEGTLVYAATDNFESQEYASQEMFDAVQAVYLRFRRDGLVIPCEIHTLAALSLSEDQHRDVMNASPDEEMLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNK4</accession>
    <name>S0DNK4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="14">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_01322</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="14"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424234.1">
        <property type="nucleotide sequence ID" value="XM_023580017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNK4"/>
    <dbReference type="STRING" id="1279085.S0DNK4"/>
    <dbReference type="GeneID" id="35394807"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01322"/>
    <dbReference type="HOGENOM" id="CLU_014329_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="16">
        <location>
            <begin position="290"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="215"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCT62153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="582" mass="65600" checksum="7BB5950021E426EE" modified="2013-09-18" version="1">MDDADSANPQLLAWVKEWLDLARERNSKGVTTYRTAYNSLKACPITFEHPAQLQQLKGFGPKLCERLEQQLKKHCEQNGLPMPPHPRSRKAIPVAGVDNGEGSPKPAKKARKPKAYVPALRSGAFALVVGLSMLDEDSSVGMTKAELIEVAQPHCDSSFSAPSDPTKFYTAWNSMKTLLQKELVYERGRPLRRYALTDEGWEVAKRIKDTEHWQAENGRAKDPTSAQPVNPDCQPISNRRPRSPSIEISEPAKAPSEYQNIVSDGPTVSDDNSLPNFTPIRLPPGSFTVHLVLDVREVRAKTDRDYMQEELAKLGAKPIMRSMELGDAQWIAKCHDPNLLISQGAEGAEVVLDWIVERKRLDDLIGSIKDGRFHEQKFRLQRSGVRKVIYIIEEISMDPEVASRYAEAVRSAIASTQVVNGYFVKRTAKMDDTVRYLARMTAMLKRTYESKPLNVIPTKILTSQNYLPLLKHLRESISPDWYITYPAFSSLASKSESITLRDVFLKMLMTTKGITGERALEIQKRWKTPYDFVKAFEACGSGEQGLKRKRELVFSQTSHLVGRKKFTKPLSTKIAEVWGDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNM1</accession>
    <name>S0DNM1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426102.1">
        <property type="nucleotide sequence ID" value="XM_023571868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNM1"/>
    <dbReference type="GeneID" id="35398283"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04802"/>
    <dbReference type="HOGENOM" id="CLU_1927784_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT64021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="133" mass="14086" checksum="4882715C8BD130AA" modified="2013-09-18" version="1">MPDQSKKANQPKKVTGSKGEATRPVNGEASGSGGNSSTQNQSASTYTPTTSGGGGNAQETPRTPERVEDWRHGTGDSWNTFNRREGNNNNVGGSSSGTVYPPELDLSSDEEDENQPDKKDESKRDGKGKGKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNS9</accession>
    <name>S0DNS9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425113.1">
        <property type="nucleotide sequence ID" value="XM_023573382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNS9"/>
    <dbReference type="GeneID" id="35393843"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00358"/>
    <dbReference type="HOGENOM" id="CLU_2333669_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="98" mass="10438" checksum="BEEFE73C3548F421" modified="2013-09-18" version="1">MSNTDPSGSSSTNSGKLSADNISRNLNINSEKDCFDLLFQEITALPERETLAPSSAPSMASQLSLISQRSSATDSTTRTNVWIAKTVRAAMSEALSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNU2</accession>
    <name>S0DNU2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_04538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426340.1">
        <property type="nucleotide sequence ID" value="XM_023572164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNU2"/>
    <dbReference type="STRING" id="1279085.S0DNU2"/>
    <dbReference type="GeneID" id="35398019"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04538"/>
    <dbReference type="HOGENOM" id="CLU_086710_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT64259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="177" mass="19766" checksum="579E38B041012739" modified="2013-09-18" version="1">MVRIKERYLLVNIVYLPDPAKAAKSDLPDFVLNHQPTIEKLTPGALIRGIRAEVASLYGDCGSGALMSCSVKYLSLATSTFILRCSRAHYQMLWSTLTFMDHVPVKDGRPCIFRVVRVSGTIRKAEEEAIRQAKRLILAAKEDTDSQSSLSLSLRNQDEMVLDVNDASSDEEMDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNV2</accession>
    <name>S0DNV2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to oocyte membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_01189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424354.1">
        <property type="nucleotide sequence ID" value="XM_023581506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNV2"/>
    <dbReference type="STRING" id="1279085.S0DNV2"/>
    <dbReference type="GeneID" id="35394674"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01189"/>
    <dbReference type="HOGENOM" id="CLU_041798_4_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="389" mass="41646" checksum="5B85DF6CB8B982D3" modified="2013-09-18" version="1">MPISPIITFKAGQCEVDASSKPYKVKPQPEPGYIYLYSEDDLVHFCWRKRSEPLDNPELDLIMVPGDGSFTPHEYTSSSEPTSKTNGRIFVLKFTSSSQRYLFWLQSKPQAEDGDPAYYSPRDRKIGEIVHQLLQGEEVDVAEEFSALRNNDSRPDDEDETMEDADTHRAPRGSGSGGAGPDATGGDVREEGEGSREGGADGARAASSSAPDADAAAAVKSFLDSLRGPSGLSGRQQQQTTDKAYPHLNHLLPTSITIPMVDSATEEFTDTLISLLPPAIIVLASGSTDSVDGKLEPSASAVEDAKASLSLDDKRTLLKKVLRSPQFNQALASLTMAIRDGGLPSIADALGVKVQDGGYLRGSGMPLGGGQAIEAFVDGVKKTVEDEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP77</accession>
    <name>S0DP77_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426455.1">
        <property type="nucleotide sequence ID" value="XM_023572310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP77"/>
    <dbReference type="STRING" id="1279085.S0DP77"/>
    <dbReference type="GeneID" id="35397890"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04409"/>
    <dbReference type="HOGENOM" id="CLU_029385_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="442" mass="48863" checksum="5A75E356CD55D96E" modified="2013-09-18" version="1">MEQTTPTIGQSEDSRSELFENNTKSETVAESTPQPPSDANPASSNSPSHPPSTSAELNNMAAHTASKKKGTASTVKKTPKRSKKTGGPRAAKRAKPTRSGSAGDAHESAGSELEESDHGPYCLCRGADDHRWMICCENCEDWFHGECINMNKEVGENLIEKFICPLCTNESLTTLYKKTCALGGCRKAARIAQGEKSVFCSNEHAQTWWERMVAKLPKAKGKGGVNDQLTQEEFMALLQGGLSGTDEEGLWRLVKAPFAGQESNVTNGTDKENSDQMHLSAEEKEHLESAAAARFHLAEETVLCHKMLTLLEFAHERRQAAITAGRFKEDICGYDERLDSIGARDAFEAFAKSPEGEAIFKASRMSDPLGEGDEVRGMCERKRCKFHGGWYKMLSLGLKHQIREMATQADEVGEEEKAMRQAAKDRWRRKQSEKNWVEVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPE2</accession>
    <name>S0DPE2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="10">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_04348</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="10"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426510.1">
        <property type="nucleotide sequence ID" value="XM_023572377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPE2"/>
    <dbReference type="STRING" id="1279085.S0DPE2"/>
    <dbReference type="GeneID" id="35397829"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04348"/>
    <dbReference type="HOGENOM" id="CLU_019796_8_1_1"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04902">
        <property type="entry name" value="ACT_3PGDH-xct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12173">
        <property type="entry name" value="PGDH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000003">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000021">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF22">
        <property type="entry name" value="D-3-PHOSPHOGLYCERATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="11">
        <location>
            <begin position="20"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="121"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="D-3-phosphoglycerate dehydrogenase ASB" evidence="13">
        <location>
            <begin position="343"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT64429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="569" mass="60162" checksum="D9478BBF91CE6B11" modified="2013-09-18" version="1">MSPSATFDTPSAGHSNRLKILVPEKVSPDGLALLTPHFDVDIRKGLTAPELINLIPNYHGLIIRSETQVTAEVVQAGRKLRVVARAGVGVDNIDVPAASAQGVIVVNSPSGNILAAAEHTIALLLSTARNVGQADSSVKAGRWERSKLVGVEVGRKTLGIIGLGKVGMNVARMAIGLGMTVKAVDPYASTDMARQTGVELVPGLEDLLPVVDFLTIHTPLLATTLDLVSEAEFKKMKKTARVLNVARGGVYNEEALTKALDEGWIAGAGIDVWSSEPLAPDSAAARLSQHLKVVATPHLGASTVEAQENVSMDVCKQVLEILQGGLPTSAVNAPIIMPEEYRKLQPSVQLVEKMGRLYTQHFVRSKGGMIGGRRFELIYHGDLAGMANTKPLFAALVKGLVATFSDSHINMVNAALIAKEKGIVISETRSGDSPSTYANLVTLRSYQAGSSGSEQVIEGYASDERVFISKLDRFNGVFTPEGTLIILHNYDEPGKIGGVGMVLGNHGVNIKFMQVASLDPEATKGADTPPDPKGNEALMILGVLGPVSGEVLEDLKNSPGVLDVGLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPF6</accession>
    <name>S0DPF6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425363.1">
        <property type="nucleotide sequence ID" value="XM_023573689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPF6"/>
    <dbReference type="STRING" id="1279085.S0DPF6"/>
    <dbReference type="GeneID" id="35393570"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00085"/>
    <dbReference type="HOGENOM" id="CLU_002346_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="7">
        <location>
            <begin position="727"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT63282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1004" mass="114626" checksum="1B3FBF9BA1002411" modified="2013-09-18" version="1">MDLSALGFPGALPDWSNLNILHRNTLPARAHFYSYPDQESALSFNREQSYFHSLNGTWKFHYDISPLDAPIWETTNTSSWDELEVPGMWQLQGYGNPHYTNIDYPFSVTPPNVSYVNPTGSYWRQFEVPQQWDGDQIRLRFEGVDSAFHVWVNGEEVGYSQGSRNPSEFDITDYLTPGQANDLAVRVYQWSDGSYIEDQDQWWLSGIFRDVYLIPFSESSIVDFQVDSELGDSFDEGSFKVNVTIQGKEGDLAISLLSPNGSTIDEWKGLSSDVYEKKLSGDDFHIWSAETPNLYTLLITFNGRTISQRVGLRRVEIKGSNFYVNGKPIIIYGVNRHEHHHLTGRTISYENMRKDLLLMKRSNINAIRTAHQPPDPDFFDVADDLGFYVIAESDLECHGFGSIEETEEEAAEWLSNNPDWEEAYIDRARQLVERFKNHASVIIWSLGNECFYGRNHAAMSNWIKERDPSRIIHYEQDRNATSTDMYSQMYSTPDDVREFIKTHTDKPILLCEYAHAMGNGPGGLVEYIDLFRTEQLSQGGLVWEWSNHGLLKKEANVTYYAYGGDFGDEPNDGDFIMDGLVLSDHSPMPSLKEYAKVIQPVSVKLAKNGSVMTVVNHYDFSDLSHLDVSWHVVADGLKTDAHALDLPRIPAGANRTVALPSGLNITQNEAWITVEFRLKEATVWAPKGHVIAWDQLHIQRPLLKAQDLSLVRRQDSGEFQKNGTKLLYRSGDSSFGFDLLQGNVTWNINGVDIFQRGPELSFYRALTQNDAASSGDGPIWEQEKIPKIYPQVREVTWRVDNDGAIVHYKVWVGVKTRAWGVEADMIYRIPTSGPQLQLESRGEFIGKNESHVIPRIGLMAVLPESFDDVSWFGRGPGENYKDSKQGSRIGQYSSTVTDLFTYYDYPQENGNREDLRWLKIGNKDVTLAARRTKDEPFSFTARRYMPFDLDDAQHPHDLKPLNMTVLHLDYDNNGLGSATVRVRPFEKYRCYTKPFNFTFNFNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPY8</accession>
    <name>S0DPY8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to Leucine Rich Repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424714.1">
        <property type="nucleotide sequence ID" value="XM_023571051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPY8"/>
    <dbReference type="STRING" id="1279085.S0DPY8"/>
    <dbReference type="GeneID" id="35394283"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00798"/>
    <dbReference type="HOGENOM" id="CLU_025206_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="590" mass="65625" checksum="3780E29E55C92115" modified="2013-09-18" version="1">MSRPESPNSNSDKTARSSFSSVRENDDGLAQTFTRSKISSYTQGPEEVFDESPSPSAEIAQPSFQAPLTQPHSRLHGFWFPADNFRGWKQIPIKGKSASRSCEDLHKLSMTWSSPAPPAVAEKASPNSYQTGSSPLERLPSEVLGAIIDLLVIEIPPNGLTPRNADLMALLLTSRSIHAATLNTLYRHITIPHSRIFRKFLATITEYPALASIVRRLDFSHFNPSTIFSTASERAQTRNLTSETLYKCLELTPYLQEFLAQEYIDEDLGPDVIKKLFFEMPRLQAIDFCGCSSPSFKNSFTSLLQAQWPDSLTLTRISFHKCLNLPGSVFEAILPRLERATHLDLAGTRVTDKALQSLPETARLTHLNLAKCRELTSEVVVKFVTTHPAIIQTITVLSLATNASSHLLLGKADVDAILPRLPPTLRSLSLKGSRMDPSQIPLLTPLVQHLEELAIGRGLDLRDIHQLLYQAQEWIPHSLRYLDISDLDTIIGSASALLTPASAPLQVIELEERAYERAAKAKKNLERAGWTPKEFGSRYWLVRLNTDGASLDSGARWWKLGAESWGMRKIPVAEADVGGMYGTFMFGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ09</accession>
    <name>S0DQ09_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to Drosophila pumilio protein and Mpt5p protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_00772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424739.1">
        <property type="nucleotide sequence ID" value="XM_023571341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ09"/>
    <dbReference type="STRING" id="1279085.S0DQ09"/>
    <dbReference type="GeneID" id="35394257"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00772"/>
    <dbReference type="HOGENOM" id="CLU_004133_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="387"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="449"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="485"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="522"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="558"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="594"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="630"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="666"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="771"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="789"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="815"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT62658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="867" mass="94545" checksum="8F88CE82F2533606" modified="2013-09-18" version="1">MDNQRKLTTNLNNSINRYSMPVTRSRTGMYDVGLDQTNTTRFLFGDEETNSGGHSGPDANFPTLVRHDDQIILSSWPSIYSSAPPQNLYCCTIVASNSDPQLYSQLSASSAALDLALSPSPNPESTSSSRGWSRVVNRHRPQQSLSSINGSSNIVSDLVGLASRPTSLRHSMDLKYISENAVETGAIMSPSATPNMATPPKLQSSFSSSDVPTVKSPGTSSSKTNNHAQQHFHNHNASLGRIPAGAVHRGHSRELSSENPAVSREQHNYPSIQSALQASAAPFGPSTTAAVQPSAMVNPSAGAAAANNNYNNNVFYSANGYGAPQGIPQVIPQGAPHQPGGYNVNMLANSMQQMSMNGANGSNMYQPQNYNGYNAGPYNQGNQPRDSQARVIQHRRQLDNEAMSRYQNTPLDSFVGNIYELCKDQHGCRYLQKKLEERNADQVHMIWVETNQHVIELMTDPFGNYLCQKLLEFCNDDERTVLIQNASQDMVRIALNQHGTRALQKMIEYVSTPQQVHIIIEALRYRVVELIQDLNGNHVIQKCLNKLTPPDAQFIFDAVGGSCVEVGTHRHGCCVLQRCIDHASGDQKLWLIQRITEHARILVQDPFGNYVVQYIIDLNEPLFTEPIVLTFKDCITQLSRHKFSSNVIEKCLRCAQPPSKDLIVEELLRNQEMERLLRDSFANYVIQTALEYATPHQKHRLVEAIRPILPQIRTTPYGRRIQAKISAFDNRGSAASSGQVTPADNTQGQIPMRATHARGISGGAPIIQGNGMPHSGPMPPMRQNMPIYSPNTAMNGQAPTSGGPVQQPQYGQMTPGNFAPNAAANGAANGSAGNSSFAGQASGNSGPTSPTNGNGNVSTGQGETQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQG8</accession>
    <name>S0DQG8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trichodiene oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426771.1">
        <property type="nucleotide sequence ID" value="XM_023572692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQG8"/>
    <dbReference type="STRING" id="1279085.S0DQG8"/>
    <dbReference type="GeneID" id="35397547"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04066"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="523" mass="59379" checksum="0AE1BE5B554E3E3D" modified="2013-09-18" version="1">MSSIKLIIPREALFNTGFLSARIWSPTSTSWNIIYYTALAFGSFALYWLCLVFYRLFLHPLRNVPGPKIAAATSWYEFYQDVILDGHYIKDYPRLHQKYGPIVRMSPNRVHINDPNFYHKVYSTGTKFLKEPAMFRFAGELDALPFIMDPAAHKVRRGIVNPMFSPRAIKDFSPLALQIIKGALKKIGDSYETGKPVSLKRLESNFAMDIIMKLCFGKDMGCTQGKEGTEALVDSMVALPHSFSLIKHFPMLGKIMQSFPTHVLTYIIPGFVEFRIQCAQWANEVRERHQNGVYTDETGRQTVFDAILDAEPDRSTKGLVDEAFSLVIGGTETTVTTITYGVWCILKNPEVEKKMLEELRTVETNSDGLMEYPNLMNLPYLTAVIHETLRISSPAPGILTRLVPSGGTKYGSHFLPADTSVSTAQRLIHYDPVLFPEPETFMPERWLDNSDKASKKNLVPFSKGPRMCVGLNLSYMEAYVFLGNLIRRFDLSLQDKDQGTLRWKDYIALHIEDDVLIKVNGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQR3</accession>
    <name>S0DQR3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_05090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425833.1">
        <property type="nucleotide sequence ID" value="XM_023571546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQR3"/>
    <dbReference type="GeneID" id="35398571"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05090"/>
    <dbReference type="HOGENOM" id="CLU_103019_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="235" mass="26350" checksum="D19D020CDA097274" modified="2013-09-18" version="1">MKFDGWVSLSLDNRIRVDNAREPWTIAIVGELLTEGRKKAMMDGKGHIQENLKQKAKEANLEAVPTSPSGLIEQLAQVVNSEIPRISFDYLTMHNIAWSFLTDLKRAFTAEVGPKFLNYIPSEDQLPFVVGYVFSTAAGHGSTDVRERGVGNDRFLNVATEVMDEFLHEGKGKIIKEAREANVEPEDVEDVDVDGSELWGPRKFNMEQFRRDGHLGARASNADVAELMRLLQMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQS2</accession>
    <name>S0DQS2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to nonhistone chromosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_00508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424974.1">
        <property type="nucleotide sequence ID" value="XM_023573214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQS2"/>
    <dbReference type="STRING" id="1279085.S0DQS2"/>
    <dbReference type="GeneID" id="35393993"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00508"/>
    <dbReference type="HOGENOM" id="CLU_042807_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="156"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="156"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT62893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="354" mass="39144" checksum="77484A2555B9F846" modified="2013-09-18" version="1">MARPKKQVVEKQQQQQQPAPVPIPPQHIQQYPQHPQPIAAVPQPAMPMPMPPPVGVPQPQAVMPQRVVEADSFLRVRDSAVGRLTTILELLRSFTADYVRQTNLLLGEPTAEGSQDNLLANFEHAAQQLIMPIPELAPPVEEKKERKKRTIDPNAPKRPLTPYFLYMQHARSIIANDLGSEAPKGAVQEEGQRRWAHMGPQEKQGWNNAYQYNLRLYNARVHSYKHGNPLAKNMTDEEALKYAEDFNVPMSEIKDAAQNEAPADDQDAIAEQLQAVAAAPAIDEPEQAETPAKTPKKATGGRKRKTATPAAAAEEAKPAPASPDKKRRRTSTKAAAAEPQEEPKKSGRKKTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0DR50</accession>
    <name>S0DR50_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_03804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427011.1">
        <property type="nucleotide sequence ID" value="XM_023572983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DR50"/>
    <dbReference type="STRING" id="1279085.S0DR50"/>
    <dbReference type="GeneID" id="35397285"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03804"/>
    <dbReference type="HOGENOM" id="CLU_060598_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="408" mass="45237" checksum="33D3412AA66EDC31" modified="2013-09-18" version="1">MTASKPASRGRTKVKTGCATCRIRKIKCDEAKPFCEKCAKTGRKCDGYESVFRPFPSKPQQIGKPDAAASGHDCAEGNPPLSTGDLNRYFSTKTIFDVELSCNEEAEEVLQASLTNDSIRHALLSLRALRGNLESKKEAVTSETDEQQRLSYNYGLQQYSEALTSLASNLAYPSPDSLKSALLCCQVLISVEQVRGNFSAMGLHIIRGLNILREYRARPYLTTDGLMSARHSGLPSLDVFIIKLFAAPCRFTEQQTSESSSVMTPPVETRSDRKLAPNMRAELTKTATSTIALLENTTKIQSEEKSQSLLLERQDLLDGLESWLGALESLQQETQPGEPESTSDNFLRILYLILKIILLGILETSPELDTKLREESKQLQDLANLVNERLKDYDMQRGIGSSLAKQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DRA4</accession>
    <name>S0DRA4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_00332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425139.1">
        <property type="nucleotide sequence ID" value="XM_023573411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DRA4"/>
    <dbReference type="GeneID" id="35393817"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00332"/>
    <dbReference type="HOGENOM" id="CLU_582876_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="520" mass="58205" checksum="DFBA274389AC98DF" modified="2013-09-18" version="1">MDVFPRMTKRSQKRKEARSVPGLIFVAFDGTWHGSSKSSKETVVSCLPRLIAKGENARKIRLNGVGSDGLTDKFLGGLGGWGTLRNVIRAYDNIAEDYNKRDRIILCGYSRGAWAARYLALIIERIGLVRNGDRAFYKRLYKACDNDPYLAKVDKSEVRGTYKFYDDVKIDALCCFDTVGSLGLPLFGIAKPLSYLHRNKYQPKTIDPVPKSEYHEYSGSIDLDFRLRHELILESDVNYAFHALALHEKRSPYSPTYMCGRNVHQVFFLGDHGSIGKIEKHEGLVHAPLAWMVQQLKSHMSITFDEDKLKERFPSYISEEQAKDASQQGRQHATRKSMEQHAWCCPSGSLPGAGIGKLFIMGKKDRDPGVALKFCDSKYPESSTDELSRHEAASSHPEIHINARGRQACGFIDAVPGYIGSLSPDSSRVWLWKRNMNGGQDGTSANIIHEARVGFLEARLLGLPLKEASELSCCDLERSREGLTNDGVSDIDGKAQRGQSTRIRVKKWFKRGFGASSEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS35</accession>
    <name>S0DS35_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427342.1">
        <property type="nucleotide sequence ID" value="XM_023573897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS35"/>
    <dbReference type="GeneID" id="35395676"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02194"/>
    <dbReference type="HOGENOM" id="CLU_018449_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="597" mass="67130" checksum="106BAC35D6E992A8" modified="2013-09-18" version="1">MENASSSSASRQPQPPKRKRVERGRSKNGCLTCLTKKVKCDETRPQCNRCVRLKLECRWAMQMQPLAERRRGLGPIKQRERWTPPTIVPKIDDAVSEGSQSVTPPALTPSGELQLSEGLPVDISFDVLPVENEVVSASPTIFPDIPPEDIINPIALPQYPHDSSQLILYPTPSFDLLSLFPSFSFTNPTEPAPSIGSDDVQAMTFHSTVLAPMKSTRKAALSAHSIFLNFAVQNPMALHFLLAFSHSELAIHHGFSHRPPLESYLHFQNGSQLLSQALVTLSPMNHVAMMLSFLYLYMFWMRRDPLEVERLRELSNSILAYVTTFSLDEVCANSSGSTGTSEPVTLSRILTYIYDRDVFCGFFGCGSAFAGYVSQKHETRQRIWLLSRMPILPEQTETWFRSETLPETSQRRILDVYFSLITIQYEINVYSQSNELAVFGKDLEIRTRLDKIREEQNFLFTLSRDCAQQSTKPPLMALVAVTIFHALEIYLHRSRDTFFGETPVPADIERALQELVSAAYHTIPVGPVQLLERFQWALLIGGIETHDPVYRDWISASISDPVIKGVYNLVVSAKTLSAKGISMEAVRELVSKQTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTD3</accession>
    <name>S0DTD3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_04994</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425924.1">
        <property type="nucleotide sequence ID" value="XM_023571654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTD3"/>
    <dbReference type="STRING" id="1279085.S0DTD3"/>
    <dbReference type="GeneID" id="35398475"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04994"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11734">
        <property type="entry name" value="ASKHA_NBD_HSP70_Ssc1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="644"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT63843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="677" mass="73225" checksum="C6CC432C45898BD6" modified="2013-09-18" version="1">MLASRLSRALPRASPLAARSAAFTRSPLAAKFARYESTESEGKVQGAVIGIDLGTTNSAVAIMEGKVPRIIENSEGARTTPSVVAFAEDGERLVGVAAKRQAVVNPENTLFATKRLIGRKFKDAEVQRDIKEVPYKIVQHTNGDAWVAARGQNYSPSQIGGFVLNKMKETAEAYLSKPIKNAVVTVPAYFNDSQRQSTKDAGQIAGLNVLRVVNEPTAAALAYGLEKEADRVVAVYDLGGGTFDISILEIQNGVFEVKSTNGDTHLGGEDFDIHLVRHLVQDFKKTSGIDLSGDRMAIQRIREAAEKAKIELSSSLSTDINLPFITADSSGPKHINMKLSRAQLEKMVDPLITRTIEPVRKALKDAGLSAKEIQEVILVGGMTRMPKVAESVKSIFGRDPAKSVNPDEAVAIGAAIQGAVLSGEVKDLLLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQVFSTAADFQTAVEIKVYQGERELVKDNKLLGNFQLVGIPPAHRGVPQVEVTFDIDADSIVHVHAKDKSTNKDQSITIASGSGLSESEIEQMVEDSEKYAEADKERKGAIEAANRADSVLNDTERALNEYADKLDKTEADSIKEKITTLREFVAKNLSGEGTATAAEIKEKTDELQVASLNLFDKMHKARNESSGEQSSSSEQSQEGEKKDENKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTW0</accession>
    <name>S0DTW0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_02868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427967.1">
        <property type="nucleotide sequence ID" value="XM_023574649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTW0"/>
    <dbReference type="STRING" id="1279085.S0DTW0"/>
    <dbReference type="GeneID" id="35396350"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02868"/>
    <dbReference type="HOGENOM" id="CLU_023866_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT65886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57232" checksum="6789E91567D2133D" modified="2013-09-18" version="1">MGATQYYRSQIGEESVIDYSHTDFPFKLLAKDVYYFFVYVWALPWVIWPVYPLKCKVFDELYPSPQNVFCVVVHLVLFFLQLGFIIALPFSIVFPVWMAATGIAGFMFTNWLICKLLNGSKETYTSDEKYAKDRPEHAHEQWVFLNGVAVGEHWMQSNLNRLALTFGRPILGIHNQTRGIIFDVVECLIQRNFGYATGDVRICFRLLKDILYDESKSKVIFVLHSQGGIEGGLVLDWLLQELPQDLMSKLEVYTFGNAANHFNNPHRHRSSQMLARLKPLSAMSTVLTESSFDSPSSSPLEAKDDLALKARNPVRKESSGVSTRSISAAKDRCILHVEHYANSTDFVAIWGILHFATNRMESRELPRFQGRLFSRADGRHGGHQMNQHYLNAMFPLKKDAATGEYVGADEDNEFMNEAIKVGEEGSASANAREAFEISWAGTQGFGSGDASTPIEVHGISNTIKEASDDHGIRVKDVSRLWSYRNGRSPVELPPMLVSENGVPRTATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUU4</accession>
    <name>S0DUU4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to Avl9 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426384.1">
        <property type="nucleotide sequence ID" value="XM_023572221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUU4"/>
    <dbReference type="GeneID" id="35397969"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04488"/>
    <dbReference type="HOGENOM" id="CLU_009066_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="42"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT64303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="723" mass="79541" checksum="151FF5F68170154D" modified="2013-09-18" version="1">MSSDESPPSGLGAPESHDDLKPILSPILPSSPASSTKVDFIPLVTVVGFHHARGPEVENWFGADDGSDPAADYGWSLLPFMALSDGAHASEEDFSYFTLLRPETETKPATSLFGISCTRQLDSSQLINRPADVTRSTVQKAVVVIADSPQFFGMLRERLSIVTQAWFAQREFTDVEILRRFQESLADEKTKGILNDQVDRDQYLGMSLRELIHEYKWQTLVLLKCCLLQPKMLFFGSRCDRLCMMQFSLLSLIPGLIRNLQDSADPELNSYEISLSKPTSLRTSDRNSLLCYMGLPLQIFGKGSLFGPYTPLQQLDILADFGTKSYIVGSTNSLLLQQKDRYSDILINLDEGSVVINSPSLRSALTLTAADRRWIDYLTHEINETWDEANPSRPKTLKYVGSEEFIRLQFEEYILALISSVKYHNYLNANPNNPKAILPEVEGDPVADFGYEWVEAWKRTENYRMWNANTDSHLFDIVDPRHPCAGGLNIEDVQRRIAEQVKELHLDERFAQGKEVLGRNLAAGREKASFVLNKLYADMEALREAQRRRAEEARAASPPNGSSQAAAQDPSKAGQQGQSAGARAGAYIGSWAAWAGEKRRTSGWGAGWGRKPASKADKSMDDSSSSSPIDKDYQMISAPVSRGGSSDDATARPGRGASFSESILSGVSESGSRPTSGINKPLPGPPVPGKKDDGFQTEGVVGSKDKLPSAGPPRNGDGITTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUW9</accession>
    <name>S0DUW9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_04468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426404.1">
        <property type="nucleotide sequence ID" value="XM_023572243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUW9"/>
    <dbReference type="STRING" id="1279085.S0DUW9"/>
    <dbReference type="GeneID" id="35397949"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04468"/>
    <dbReference type="HOGENOM" id="CLU_027018_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT64323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="418" mass="45782" checksum="97219183C502C455" modified="2013-09-18" version="1">MAASTPANSLLSNQKSSELQAVLHPLVLLTISDYITRHTLRQQEGPVIGVLLGQQNGREITVEHAFEAHTRQEPNVQGGYLLDATKFSARLEQMITVHKDRHLDLVGWYTLLPSSGPTPTILPIHNQILEGWNESAILLGFHPEQALDHSVGGRLPLTIYESNYEVDDPKADNDGEDKKMDDGEPALKLKFRELPYSVETDETEMISMNYVAASGGNAAAAPQKEDKPSLSIESNGKGKRRLVESHDEDHNKATAQDDEVALTPEEDETIAALTAKANAIKMLQSRILLLTTYLERLPPSYINGNTTDSSSMDADYTTPSATVLRQIQALVSRLDLVIPSDRAAFEREMLHEANDVNLVTLLNGIVQSVGQARDVGKKFYVVENAKASHRRGAPPGPGQDFVIDPAAYNIRGAGDLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DV03</accession>
    <name>S0DV03_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to vacuolar zinc efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_03299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428366.1">
        <property type="nucleotide sequence ID" value="XM_023575132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DV03"/>
    <dbReference type="STRING" id="1279085.S0DV03"/>
    <dbReference type="GeneID" id="35396781"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03299"/>
    <dbReference type="HOGENOM" id="CLU_023518_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT66285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="541" mass="59559" checksum="0EE87DE9A5EE3850" modified="2013-09-18" version="1">MATSVGQSSLDNDTRGWIMCVVSGIACVVGASIVCVDVIVRLFPGKRNFRIQDSNVFLACSLSLSFGVMLFSALYSMLPESKEYFQQAKWSTQAAGLVMMSCFAGGFIGIQGVSRLLHQFMPTHVVECDHTHDENATKDTSCHHERRQSRARRRQSSHPPPEQAPVNKSLSKSTNGNGQNAATESTPLLESTLDSPSQTLKRQASARDGMRRPASPTRSRTTTGLTDGFPERRKSMREVHKRVMSFVQDTKCNCDESNSCYGFTDPCGQECFKHLSSRTSLPSRPGRQPQILRTTTGSFLNRAPEHSHAHHDHEHEHEHEHENGCEDSVEPFARPTYRTSRAKSREPLDPIVPEELSEHDSSCSSAGDDEDVEAQHHHHVPTNAFLSIGLQTSIAIALHKFPEGFITYATNHVNPSLGFNVFMALFVHNITEGFAMCLPLYMALGSRWRAMAWSAFLGGLSQPIGAGIAALWFKLADKTNMQPNAVAYGCLFAITSGIMVSVALQLFVESLSLNHSRNLCIFFGFLGMALLGFSNALVGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVJ5</accession>
    <name>S0DVJ5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428587.1">
        <property type="nucleotide sequence ID" value="XM_023575401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVJ5"/>
    <dbReference type="GeneID" id="35397024"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03542"/>
    <dbReference type="HOGENOM" id="CLU_024934_9_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="398" mass="45542" checksum="6BC215BFF71D6021" modified="2013-09-18" version="1">MCSGTIPVTKTPGIQRRRKSRFGCRNCKLRKVKCDESRPCCVNCQIYGVVCNFGFNVPDFQSLPEERTKKNVLKQFAIPSPQSSMDNCIWVADGATFYMLNAHDQDLFNRFQCRTLHSLGGPEIVEIHNRHMLALSFKRPFLWHGMLAVTAVHDRYLGVTPTHRRSFCETYHWSQCTSLFKKSLGQPIEEEHKDPIWAAASTLGILAFSSINACPLEEAWPLGPPDSSDLEWLRLAAGKMRLWQLVNPLRETSIFAPMADTFNTMHQSLPIEGINGVLAELKQLCMLDETSTAYNNPYFRVAHGLSELLATPVGQATIGKAMKFSTKILGEFKTLIERKDPIALTLLYLWYTRARECRWWIDIRATYEIPAIRTYLQRYYQDWGHVQKLLSRVDIGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWC4</accession>
    <name>S0DWC4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428851.1">
        <property type="nucleotide sequence ID" value="XM_023574241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWC4"/>
    <dbReference type="GeneID" id="35408263"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14893"/>
    <dbReference type="HOGENOM" id="CLU_137473_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT66770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="100" mass="11512" checksum="1E1B89F21D9B079F" modified="2013-09-18" version="1">MISTTLTRLRPMVSSRSPKIIGVSRRTYVNKPPSPVSQFYRTFTRPIAKTLLIAVFTYQLAYWTWVKLETDEIRAEREATIEKLETTIKDYDAAAKANKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWV4</accession>
    <name>S0DWV4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429026.1">
        <property type="nucleotide sequence ID" value="XM_023575766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWV4"/>
    <dbReference type="GeneID" id="35406574"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13120"/>
    <dbReference type="HOGENOM" id="CLU_036324_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004484617" description="Integral membrane protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="48491" checksum="1257518FBA333F03" modified="2013-09-18" version="1">MLSLLVKATTCIALLLCLTWYGQTHFYRDPGSVFFDKARAYETRYSKHRKAEVEKLINSYPELKKPAPGQVRDGNKLLCIALSSVKRETHYLPMTIGSIVHGLSKEERNDLLISILIAETDPRRHPGWNHQWLNHAADDIFTYDVNDTQAKHLSDLEQSGKYQEKGVFDYTYALERCYATGALYVGMFEDDIILAKGWFMRILQGLSEISDSSNWLFMRLFNQERSTGWSSREIGGNNEFLIILGIDIGIAASVWLVRRHWRSSRKYLDMETLAVTTLILVPGLIVLLYQSGKASLFPPPPGIFKEPFGCCSQAMIFPRAQVPLVIDSLKERKEGQIDLMLDEIASSNGLDRYALYPVLAQHIGVDSARKTAKDEAQAIWSMAFENHNPRTLKKEHNKLLENYEVWREKVEQDTLDSMYLDELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DX10</accession>
    <name>S0DX10_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429175.1">
        <property type="nucleotide sequence ID" value="XM_023575945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DX10"/>
    <dbReference type="STRING" id="1279085.S0DX10"/>
    <dbReference type="GeneID" id="35406731"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13277"/>
    <dbReference type="HOGENOM" id="CLU_028978_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="649" mass="71932" checksum="B2636C19FD504C91" modified="2013-09-18" version="1">MASASILQSLSTSTTLTSSAPSPTASSTPLTILIRNSIEGTSDFFPFVDIAGLGSGSDDVNSGLTFKELFATSLDGNQEITLFSSGCQVDGRTDCTRACNNSSLFFSSLETFYNCAALAAAAHWTQDAKSYYVSQETERNASAIMGSGTLSEFDGRPVLRSLIACAQDSCDNDGLSKPCNRTIDRLSYDTSTPEEIFEALDEFCPELPAEVNPDIFGPGVLISYVLQVCFAASLYLLLKGFTLWVTITQDTSRRKSEPKPYRLKRSLTRIESMIWRDSGGLSRTSIAIATTLVEFQEAQCWFVFAVQIASILAIVVNSQEGTFWGEIVVNAAIAFHVSQNGILPMFLVQVCLHHEGIRNWHTFLGFFMEYLLAIVATSQKIYFKDAFALFKSQNEIEACGFNPSPRTYCAATQGIDGQSFSFFPHPLLYKMTFLILDTIAIIALVADQLAWTLRKHHLTKHVQIGSYRLGRWPRWGKQKRGLFIKIWFWRILEVAYLVINILYMISLTKVINAESFAANRWSYGQIIAVTVWGPVIVKLFDLLLSGPPKNGMRLNSGPPRLRIDNVINGRVGTSADEVIEDDNETDEKCDEPEPRARDEGFMIRQAATVQLADPNHDGRDIECEAIEPEPKAASREGISAERDVKGTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXQ4</accession>
    <name>S0DXQ4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to Ngg1p-interacting factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429430.1">
        <property type="nucleotide sequence ID" value="XM_023576255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXQ4"/>
    <dbReference type="STRING" id="1279085.S0DXQ4"/>
    <dbReference type="GeneID" id="35407010"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13556"/>
    <dbReference type="HOGENOM" id="CLU_037423_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="301" mass="32325" checksum="70E131E9AF2D4930" modified="2013-09-18" version="1">MADNGAWGAWQVESSTFTKAVVASMQKLYPEQIADKSWDNVGLLVGNSENDDKKTKKVLVTNDLTYQVAVDAIEQDVSVIVSYHPFIFGGLKSITNRDPQQATLLRLAKAGIAVYCPHTAVDAAPEGLNTWLADIVSGPHQSRRSVAIPCSSAPPSHSGAGYGAIGRFDNAVSLSEIILRLAEKLGGLKHVMVASPVGADVKTTKISSFGVCAGSGYDVLKKAEVDLLVTGETSHHSALRAIQQGQTLVQVFHSNSERGYLQEVLKPKLEAAIKENVPEVEVVVSKYDKDPFTILDVNDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXS3</accession>
    <name>S0DXS3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to alpha-actinin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_03175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428253.1">
        <property type="nucleotide sequence ID" value="XM_023574992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXS3"/>
    <dbReference type="STRING" id="1279085.S0DXS3"/>
    <dbReference type="GeneID" id="35396657"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03175"/>
    <dbReference type="HOGENOM" id="CLU_005217_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21291">
        <property type="entry name" value="CH_SpAIN1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000138">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000279">
        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="246"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="360"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="720"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="860"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT66172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="890" mass="101212" checksum="EB64F51DA82288F5" modified="2013-09-18" version="1">MDVTKDSPQGMLPLQPGNVMGNEKFPNFCLHADAQSSDDCDCNQQQRYQGNKEDYYAYHADLSINNNSNCNQYHQHFHNSPSASISASSRLSYISTVSASASSSSSRISTASFESLPITPISVFEASPHSPRCLSNRLSSSVTGFIARHRTLTQDSCSISYSPPSSPTPRTRRDKLQLHATRVQRSGSKSTNTTFILGLQKRKLSTNSRRFPPSASNPADALAAVEPPHDQRSTRMAFAEQQRWVTVQQKTFTKWLNTKIEARNLEVKDLVKDLSDGVMLIHLLECLSHESLGRYASKPKLRVQKFENANLALDFVKSRGIQMTNIGAEDVVDGNQKIVLGLIWTLILRFTISDINEEGMSAKEGLLLWCQRKTACYDEVEVRDFSASWNDGLAFCALLDIHRPDLIDYDALDKKDHRGNMQLAFDIAHKEIGIPKLLDVEDVCDVAKPDERSLMTYIAYWFHAFSQMEKVENAGRRVEKFVNNMQGAWEMQSAYERRMRALLQAIQEQIEVWKQATFEGTYADAKAQSNQFFEYKKGKKRQWVAEKSDLATLLGNIKTKLGTYRLRPYDPPAELSLDALERKWAELASNEMTRAQLINETIRDIKNALRKSFADKANDFAMALNTMQLALSGLDGDVEDQLHHVRKLSESLSPLDQYLDKISELDQKCQEANIEENDFTTYTYDELSYELGLVKTSVQKKLAFLENQMVARSMTNLTPIQLEEFESVFRHFDRDDTNSLQELEFSAALASLGLVFSEDEMHDYFHETSGGRDYVTFEQFIRFMVDVTEDQNTAEQVYQSFREVADGKPYVTEMDLRHSLVPDEVIDQLIEIMPPHSGPDMSEDRGMPQYDYISFMEKLINDQNNQQENSEATQRSRSDAEPQSPHTNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY32</accession>
    <name>S0DY32_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to YER185w, Rta1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_03331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428393.1">
        <property type="nucleotide sequence ID" value="XM_023575167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY32"/>
    <dbReference type="STRING" id="1279085.S0DY32"/>
    <dbReference type="GeneID" id="35396813"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03331"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT66312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="298" mass="33039" checksum="A62C07368B627FFD" modified="2013-09-18" version="1">MPYNYTIRPEDAFGSDSPCNLDTCPVDWSIYSYRPSLAANIVFVVLFSLIGLVHAYLGFRWKSWGFMTGMLLGCVSEIVGYVGRIMMWYNPFSFNAFMIQIVCLTIAPVFYTASIYVTLSKTINFFGPELSRFKPALFYWIFIPFDIVCLILQAAGGAMSTESDSNVGVDVSMAGLVLQVVVLVVFIAAFSDYMIRYWRSGHAKAFGWRETAFFAGLSSAIILVLTRCIYRVAELREGYDGDLIKHEVPFIILEGIVIVLAAVALCFGHPGLVFNKPQVTTSISQVEKGVASGSESNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ28</accession>
    <name>S0DZ28_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427804.1">
        <property type="nucleotide sequence ID" value="XM_023574455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ28"/>
    <dbReference type="STRING" id="1279085.S0DZ28"/>
    <dbReference type="GeneID" id="35396174"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02692"/>
    <dbReference type="HOGENOM" id="CLU_027634_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="108"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="407" mass="44575" checksum="DEC82F9EE077E2F3" modified="2013-09-18" version="1">MANEVLIPFQDQQKPTSHSPVPEGLNLIVYEQKIVDGFDGIAQTRNTRYSTATFPDAFTATSTVDTIFVCAEDQSQKKQSWPPVEILEAQSSSDKVHVFNSQDVVPSFPSEDSKLRATSLNIRRGGNCPNSLQVLEQLLSERDTLQLHLVSPLPATGSSATQRVISSFGEQSNIDFSHCVYREESTEAASSYIMRSEASGSRTLVNYNDLLEMTEDEFGNIARGFNPDQETWWHFEGRIPDTIQSCIRLLRNVLPKATISVEIEKPGREGLPELAAQADVVFYSRSWAESRGHKTPEQCLRVEGHQKASLALCTWGEDGAAGLSRSTGESIHCPALDKSGRDISVIDAVGAGDTFIAGMLYGLICHPDDWTMGAKLGFAVRLATVKVQREGFDGLGRDMLGTEIGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZ51</accession>
    <name>S0DZ51_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to serine/threonine-protein kinase Chk2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_02724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427834.1">
        <property type="nucleotide sequence ID" value="XM_023574490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZ51"/>
    <dbReference type="STRING" id="1279085.S0DZ51"/>
    <dbReference type="GeneID" id="35396206"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02724"/>
    <dbReference type="HOGENOM" id="CLU_000288_171_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001380">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000841">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="286"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT65753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="671" mass="74949" checksum="E382CF8C311EE5A0" modified="2013-09-18" version="1">MAPQPEKSQLKRPRGSLPDDETETKKPRRAERLEADPDKTPIVNKQHLPSPLTHLTDDSNELNKEPTATPPGQNQHEITPKKTEDTCSQGQALSSPPQDTQPLSQFVDRHPAISDDIEDEIREGVWGYLVPLDPKYGDKPIVLKKRSACPLPHTVADSAKQDNKHHANENGKSAAMKDEEAFEKKKEKGVSSGGYLIGRHPECDIVVNDGIVSNRHCLIFTENKGNDTVAIVEDLSSNGTYVNEAIVGRNQRRELEEQDEIAVHGKARFVFRYPQSRQTSAFLQQYTLLEKLGKGHFAEVYLCVEKATGQRFAVKIFTKHPGVEDRSKTEGLQQEIGVLMGVSHPNVLCLKDTFNERDRVYLVLELAPEGELFNYIVMKQKLSEDESRKLFVQLFQGIKYLHERNIVHRDIKPENILLVDKNLHVKLADFGLAKIIGEESFTTTLCGTPSYVAPEILADSKQRKYTKAVDVWSLGVVLYICLCGFPPFSDELYSRDFPFTLSQQIKSGRFDYPSPYWDSVGDPALDLIDSMLIVDPEKRFTIDQCLQHPWLTQSSPGVNDSTGGLVGGIAGLEVNRRAPARERTLLASLNTVQVTAQLEVGKDKNPVKVFSKNKGRVTNVAKESDPAAQRAPDEFVEMGGKGDQELFADDDSSIYPIGDNGEKIKANKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZL6</accession>
    <name>S0DZL6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable SPO76 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_02909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428004.1">
        <property type="nucleotide sequence ID" value="XM_023574696.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DZL6"/>
    <dbReference type="GeneID" id="35396391"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02909"/>
    <dbReference type="HOGENOM" id="CLU_002562_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1263"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1270"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1296"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1334"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1351"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1397"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1436"/>
            <end position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT65923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1457" mass="163019" checksum="76F3202E9C0EBF37" modified="2013-09-18" version="1">MARRRRVEKPAQVEEEEEEVVEREDEQDQEEQQHEEPDHDSENEEEGEQRSLTFDEEISWKPAKPIPTSTLIKRLDKLSKELSDLDQGAADLDSIRHVAKQLGHRNLLQHKDGGVKAYTACCLVDILRLFVPDAPFTDDQIKMIFTLFIKDILPALHDPTNPYDSQHKYVLASLTEVKSILLLHQISNADDLLLRLFNSTFDGVSASGSKPASEEQVAKDVEIHLTEMLMQLIDEAESVSASVVDAIISQFLRAAPPGGNRHRGQNGNQSTLLLKEEPPAYVMAKNICNGCSDKMARYVSQYFSDVILNASGFATKSNVQRHPDDSDDEDGTLGPSEADLRSLRQAHLLIRELWRAAPTVLSNVVPQLDAELSADNVHLRQIATETIGDMVSGIGAAGPPPPPSLEPAAYPPIKLLDDNPTPAVENVLTKPYSPQSFAQTHHATYRNFVGRKNDKAAIIRAAWISAAGYILATSAGGIGLSQKVRLAAVQAVELFDFRDIVLKLGALGGVEKTGSIFASLADRSRDKKPAVRVEAMVLLAKLWSVGAGEIADGQEAVISCLGGVPSRILSVWYIGDEDLIILLERVMFECLVPLKYPFIKGAKSKVASQSQTASSQADQDKIRAERILLLLKSLDASAKRAFFIMQARQPQVAKGVEVFIQQCEAYNGGVINANEEKVKAALSKTFQWFGAFFPDPLKVRSDLQKFAKLNDRRCYQLLKFIIASDTEYLHVRRAIKELIAKVQSNPGSASCLDTLIPLIYRAGSLMYNRSHLATIMDYSKNDKAGFSTVAHEILNDISQRNPALFKAHSDNLRKEIISQAPSGSEPNEPAVVDILKAYSSYSKRYPQEITYDKKFIQVLMDYALCGVPARSAKYAVNILLAKNDDKSKVTATALLQRIMKDFKYGSPHFLTRLAAVSQLERLAPTVTLDFDGTINDLTIKQILRQVRTDDKNSEVSWVEDEDMNEELQAKCLAMKTLVNQALANQDDDDSLTRVKLVFKLLKEFVVQEGEFCKVKDTPLAHKKRLRLLAGLLILKLCTVKKYDDEFDPASFNKLAELVQDTELEVRRHFMEKLQSYITQGRLRARFYTMLFLAAFEPAIELKSRVETWLRSRARLFAQNKTHVLEAMISRFIPLLAHHPDYSSDVDDLADFANYFVFYLNTCATEENISLIYKYAERVKQTRDALNPEASERIYVLADIAMAVTRKWQERKNWVFQAYSGNVGLPSGLVQSLPSSSVAHEIAQKQHMPEELDEKLDELLKAADRKKKRKSTGEKQDPPAKRARTQIKTVIREKRDSRPKKVSKPRKSKPVKETPPPSERRRSGRAHKVSVYTEREDEEDEEEMLEGVADWEYPENDSEGGEASAGDDESELSDAPPEEDENDDRNKASDNDEPPEPEAGKPEEARFNGRNAAPSLKGRGASKPAVKASVLAEVKRPTRSTRPRRGKGTDEMEVDVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZQ3</accession>
    <name>S0DZQ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430134.1">
        <property type="nucleotide sequence ID" value="XM_023576991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZQ3"/>
    <dbReference type="GeneID" id="35400287"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06810"/>
    <dbReference type="HOGENOM" id="CLU_144291_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT68054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="153" mass="16302" checksum="0292BCC78E207C73" modified="2013-09-18" version="1">MKEVSRNLSAVESAVAQLCAALRGDAQSKAGQTRINIAAINLKSALQAMGDSQSAVESSGDDTKKKALQDLIGPFSKGLSQFAKIITNVYDRGPLPDTVALDLKPVLAKYEEVQKSYQKLATESGLKIDLYMPGMSNVLPTNVEEAFGKLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZS7</accession>
    <name>S0DZS7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_06862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430179.1">
        <property type="nucleotide sequence ID" value="XM_023577050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZS7"/>
    <dbReference type="STRING" id="1279085.S0DZS7"/>
    <dbReference type="GeneID" id="35400339"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06862"/>
    <dbReference type="HOGENOM" id="CLU_038610_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT68099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="382" mass="42569" checksum="594A89B5733D5E63" modified="2013-09-18" version="1">MSPSCRSIKPRFTSLSPSPEITEGLKKADRACEKCTRTKKKCDKSLPGCSRCKRLSNKCCYDYVYTPSVTTVIRPEHAIKSPPHIPGTLKPFLDISSSMILSLLSSRNAIPSHSVQHYLETINPYLTIVHPELFALRTNITGSDSFSNQELQDPATTLLVVCMQLFSQSDDSGTEGEESADRAVYRSAKQILSVLRAIESPNIELIQCSILLAFYEYTHEDLGRAYLSIGDANTMALILHVGPGKYLEDEREALIPYEEEERRCVYWSLFVLDRLVQTDYSLLHMPHQIPPAVVSPPAADDLLPTNHLLWYDEGQSPYYVTQRYPADTDFSVPVGAFQRNCQYAMLYTGISPPQSPAGPTAFELGNHTVTSASVLPISILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E059</accession>
    <name>S0E059_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">FFUJ_07015</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430324.1">
        <property type="nucleotide sequence ID" value="XM_023577220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E059"/>
    <dbReference type="STRING" id="1279085.S0E059"/>
    <dbReference type="GeneID" id="35400492"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07015"/>
    <dbReference type="HOGENOM" id="CLU_035826_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 17" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="19">
        <location>
            <begin position="288"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="56"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="438"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCT68244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="476" mass="54511" checksum="185AB98F6D5DACE5" modified="2013-09-18" version="1">MNHALRRAALGVSPALRASRPHTQFASHQLPALYRCETKQTAFRRAFTTTRCLNQEAATADSQEETARKEELSEKARKRDMKKVTSGASAQTLENDRPWHRVDSEAEKDPDIPDKTEMKKGRLLTTPTRLLKLILPMPFHPEQEHVNRPVQQDVEDKGETVEPLALLVHPHQPLSYLERLIQAEIPPVQYKGREKLPDIVFRAEADQEEQHGKKEDKKNSSGNVASYSGLGHEGPSRKEANWVRWSGSTEIGDFIRDAARGREFAIDVEGFDKELRVAVPSFRDRTYYMRMNLRRMSRDIEGMSKVKNECDALAHKGAHRLAQGGFAALAGWWGVVYYVTFHTQWGWDLVEPVTYLAGLTTVMGAYLWFLYISRDLSYKAAMKVTVSKRQAALYQERGFDQNRWEQLVHEANQLRKEIKVVASEYDVDWDEKKDLGGEQVRKVLEEEQKGRDGTKMTEGKDDEESGSTEEVKKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0E097</accession>
    <name>S0E097_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to tetrahydrofolylpolyglutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_07069</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430374.1">
        <property type="nucleotide sequence ID" value="XM_023577280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E097"/>
    <dbReference type="STRING" id="1279085.S0E097"/>
    <dbReference type="GeneID" id="35400546"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07069"/>
    <dbReference type="HOGENOM" id="CLU_017455_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="9">
        <location>
            <begin position="51"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT68294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="681" mass="76730" checksum="22BB5475783DD955" modified="2013-09-18" version="1">MSSIQEIQFAISRINRVLASKRTPGYRDIRLGLDRINRAIPDKQEWKGIHVAGTNGKGSICTFLAGMFKLAGLGYGSFTSPAFPERHNGVTINGLYVNPRMYEMEMKHVEEKYNRIAAGWKYKHGEEPPNLTPFEFETATAFRVFNKMHVPYGIVEVGMGGATDATNAMKQKSVTIISKIGLDHQEYLGNSIEHIAKVKAGIMQRNVPCIVDHTNKPSVIHVLRKHAREIGTDIILTWKGEPLLLTLDNSKWMLESYQVQNLLCAAMAFRHLFPLQEINLDKLMETDPFLPGRLETVQVNAPLSGIQPREILVDGAHNMLGITELRNHVNKRLRKGDQPVTWVMGMSQSKHKPFFKMMERLVEPQDNFAMVEFTQGPNDPQPLPASFGTEYAQMKQIAPGNVYSGTPDIASALPWACKKSGGGPLVVTGSLYLIRQLLGLKGIRRRRELGTRRPGRAQLYRYSKIARERNLTDEEAREFKQARRHHFLSPKRSKVFAQVHDGGPIQPLKVPVKTRELQRMAAFHNKQAEGYRKSIAAIKRDMESPKKKTDKPETAVENVASRLADLEAQAAKHKAEYEDAMFKIRGHRALPHMKYKSHRQVFGYPATPKPPTKSPFQPAGSKKKRKGKSKHSSKDNKESFKDQLAAAEKQRALEIKQAKARDSSDPFEAQVAANRKTEGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0I8</accession>
    <name>S0E0I8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable 3-demethylubiquinone-9 3-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430391.1">
        <property type="nucleotide sequence ID" value="XM_023577299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0I8"/>
    <dbReference type="STRING" id="1279085.S0E0I8"/>
    <dbReference type="GeneID" id="35400563"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07086"/>
    <dbReference type="HOGENOM" id="CLU_046006_22_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990:SF2">
        <property type="entry name" value="PHNB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990">
        <property type="entry name" value="PROTEIN YJDN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="PhnB-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="166" mass="18415" checksum="A54142FBF431790E" modified="2013-09-18" version="1">MSIGKLTTCLWFEDQGEEAAKHYVSIFAPDSKINTIQRYTPAGQDQHGQEPGRVMVVEFELRGRSFVALNGGPAKWKFSEAISLMIDCKDQAEVDHYWGKLSEGGDEARQQCGWLADKFGVAWQVVPSALKEMMGSEDKAAAGRATAAMMEMKKFDIAELEKAYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>S0E145</accession>
    <name>S0E145_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to CHD1-transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_07278</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
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</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1E5</accession>
    <name>S0E1E5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to sporulation-specific gene SPS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023577604.1"/>
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    <dbReference type="GeneID" id="35400838"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07361"/>
    <dbReference type="HOGENOM" id="CLU_035846_0_1_1"/>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495456" evidence="5">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT68571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="398" mass="42283" checksum="677BF2D1645B5C66" modified="2013-09-18" version="1">MHSVKVLSAIAALGVSAVSAATCTKDIKITEPTQVISCDVVDADVIIDKSVSGAVVINGPKQIKGNFQAKNAGDLISLSSTSINSITGTFELNNLEALNNLDFSSLESLGELSFIKLPRLGELNFGTEGVTKIKSIRITDTFISDLSGLSVASVESFQIDNNRKMNAFNSDLVNVTTQLLIFDNGNDVMEITMNKLETAAEIQISSAKSFKVPALQEVTKSLKLNANPELQTFSAPNLTTITETLSLIDMKKLTNVSFPVLEEIGGGFTIQNNTKLDAIDGFPKLEKVTGGVALRGSFEKVELPKLDQVSGSVVVSSTTDIKEFCDYFDDLKKDNKIDGEEKCTSNNKEANEGKDGGEESDGSSDSSNSDDKEDAAGIVSVNMAVLALAGVAAVAQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1F3</accession>
    <name>S0E1F3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430605.1">
        <property type="nucleotide sequence ID" value="XM_023577549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1F3"/>
    <dbReference type="STRING" id="1279085.S0E1F3"/>
    <dbReference type="GeneID" id="35400789"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07312"/>
    <dbReference type="HOGENOM" id="CLU_082824_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT68525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="217" mass="24211" checksum="AF8AEB5E8CAF78BD" modified="2013-09-18" version="1">MTSLISRTMRPAALRRIVSIPVRPLTTTISQRSDNVSSSELKVGELQGAKFRVEPLRRVGEDDATKRARLVYQSRKRGTLESDLLLSTFAAAHLPTLSPELLDQYDLLLDENDWDIYYWATQKEQLSTTNPSSAQSPSTADIDAKPESDQITRHPPSGEWAQTVGNFKPAYRPVPARWKDSEILEKLRAHVRSRSVDGGEGGGMGFMPPLEPPEVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1P1</accession>
    <name>S0E1P1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase/Bleomycin resistance-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_07416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430695.1">
        <property type="nucleotide sequence ID" value="XM_023577665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1P1"/>
    <dbReference type="GeneID" id="35400893"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07416"/>
    <dbReference type="HOGENOM" id="CLU_127592_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd07247">
        <property type="entry name" value="SgaA_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052164">
        <property type="entry name" value="Anthracycline_SecMetBiosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053863">
        <property type="entry name" value="Glyoxy/Ble-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993">
        <property type="entry name" value="GLYOXALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22677">
        <property type="entry name" value="Ble-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase/Bleomycin resistance-like N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT68615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="114" mass="12686" checksum="5C8EB742C408BBE9" modified="2013-09-18" version="1">MCEENLVQEALGQICWLEVPVRDVPRAKAFYVELFGWEFVPEPQKAVGDCVKSMHFFNKGKTLHGAFLEHDEDYHVINNNPDKPGALPVLPTLCVLDCEETLAKANAIGGKTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2I4</accession>
    <name>S0E2I4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_07940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431086.1">
        <property type="nucleotide sequence ID" value="XM_023578249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2I4"/>
    <dbReference type="STRING" id="1279085.S0E2I4"/>
    <dbReference type="GeneID" id="35401417"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07940"/>
    <dbReference type="HOGENOM" id="CLU_009437_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="61"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="417"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT69006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="785" mass="89639" checksum="419ACA8314534652" modified="2013-09-18" version="1">MRPLFRMYNSRLPTIVAEPCANLPPLQVILASSDAEFLDQLIPVLKDATHSNRTPLLTQCLSRYYEEREAEIERIGLTRHEEFLDSINHLQTVRAETVTLTQEILSLNESIAESTKKLAIQKEALVNTSAVRQNIADATNALNDSLTILRAVNNAHELVRRKNYYAALKSLDDLQNEHLVPIIQNRYSTQHRLADVIQKSIPASQKAISEAVMTDLNTWLFRIRETSQFLGEVAFYHTEMRRTRQKKRIEEDPFLANFKLNSAIELVSDENEDFDVLNNEELQVDFTPLLEALHIHEALGQLEKFRSEYGATRRQQKDLLLPGFVELLAEDEQSLSSLLEGIAGFAIIEKATMQRVPHLRSANDVEELWESMCTAVINLTSKALSDIENAEALIKIKTIIALFIQTMEGWGYTVTMLDNFLLKLFDKYAELLKNRFSVDFQEIVSTDDYMPMAINTPEEYEKVVNVSWFTQEKPTDQLTYPCVLPFSQMYPLCCIDIRNFLNQFYFFSDDHFQHPNVIDETLKKSLDELLTEKVCKSLVERLSSQYLGQIVQILINLEHFEIACQELEQLLIRARSSTSAGGPVKLKATDSFRNNKKTAEKRIFELVNSKIDDLIETAEYEWTASTVEKEPSNYMQTLTRYLSNIMNSTLLGLPREIKELIYFDALSHTAEKILALPLSPDVKHINPNGVAALAQDVDYLVQFVSSLENGQMLRENLDELAQTIALLQTDNQDEFFDISTRNKKYGRVDALNGPMLLEKLTPITASPVRSAPLANFSSRFGINRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2Q0</accession>
    <name>S0E2Q0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430012.1">
        <property type="nucleotide sequence ID" value="XM_023576663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2Q0"/>
    <dbReference type="STRING" id="1279085.S0E2Q0"/>
    <dbReference type="GeneID" id="35408080"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14700"/>
    <dbReference type="HOGENOM" id="CLU_2333765_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="98" mass="11203" checksum="DB26CDD5D9B7A359" modified="2013-09-18" version="1">MFSGAANVTGGSVIINPNSRHYAELHDAMRSRYGNVSCFPQDISVLRDNSINLVERVRKANQNTVNVLRVFASHRAVARVNHPSRFRGLEYTNYERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3I9</accession>
    <name>S0E3I9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_13473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429354.1">
        <property type="nucleotide sequence ID" value="XM_023576163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3I9"/>
    <dbReference type="STRING" id="1279085.S0E3I9"/>
    <dbReference type="GeneID" id="35406927"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13473"/>
    <dbReference type="HOGENOM" id="CLU_010245_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="608"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT67273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="643" mass="72846" checksum="5E9730FE379275A8" modified="2013-09-18" version="1">MAAHISNGNGALSPASSYEGATLADLPKSWHLTESLPADSIFPTPADSHKTPRDQITPRQVRNAVYTWVRPAEQKDPELLAISPAALRDLGIKSGEESTDDFRQLVAGNKLYGWDEEKLEGGYPWAQCYGGFQFGQWAGQLGDGRAISLFETTNPASRERYELQLKGAGMTPYSRFADGKAVLRSSIREFIVSEALNALKIPTTRALSLTLLPDSKVRRETIEPGAIVLRFAQSWLRLGNFDILRARGDRKLIRQLATYIAEDVFGGWDKLPGRLEDPEEPVKSLDPKRGVSSETIEGENGSEENRFTRLYREIVRRNAKVVAHWQAYGFMNGVLNTDNTSIYGLSIDFGPFAFMDNFDPAYTPNHDDYTLRYSYRNQPTIIWWNLVRFGEAIGELMGAGANVDDTTFVNEGVTKEQEAEVVARAEKLITQAGEEYKAVFLAEYKRLMTARLGLKTHKDSDFDILFSEALDTLEALELDFHHFFRRLSKLKLQDIATREARNEKASVFFHKEGPPTTISEEDARARLEIWLESWRERIIEDWKDGGGNVSESTDGDRIEAMKRVNPNFVPRGWILDELIQRVEKGGERDVLNRVMHMSLNPFEDRWDGETFNGKTYNGDKDEELRWTDDPPKTERAMQCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3K6</accession>
    <name>S0E3K6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431446.1">
        <property type="nucleotide sequence ID" value="XM_023577798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3K6"/>
    <dbReference type="STRING" id="1279085.S0E3K6"/>
    <dbReference type="GeneID" id="35401011"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07534"/>
    <dbReference type="HOGENOM" id="CLU_040063_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140691">
        <property type="term" value="F:RNA folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="3">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="298" mass="33794" checksum="40E5BF3485264CD2" modified="2013-09-18" version="1">MIRKQARQRRDYLYRRALLLRDAEISEKRAKLRSSLASGKPLDPSIANDKSLRKDYQYDESRPDLTTNEQLDLDDEYAQLSGIVDPRVLVTTSRDPSARLSAFAKEIRLLLPTAVRLNRGNLILPDLVRSAQSAGLSDVVLLHEHRGTPTALTLSHFPHGPTVSLSLHNVVLRHDIPGSVRGTVSESYPHLIFDGFTSRLGERVVKVLKHVFPPREAITSKNKVGNRVVTFKNIEDSIEVRHHVFVRTGYDSVELAEVGPRMTMRVFEIRSGTLDNKDGDVEWHLTQYTRTAKKKNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3S7</accession>
    <name>S0E3S7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable SCL1-20S proteasome subunit YC7ALPHA/Y8 (Alpha1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_07214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431425.1">
        <property type="nucleotide sequence ID" value="XM_023577441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3S7"/>
    <dbReference type="STRING" id="1279085.S0E3S7"/>
    <dbReference type="GeneID" id="35400691"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07214"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT69345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="253" mass="27766" checksum="B3CBB7F85CD15534" modified="2013-09-18" version="1">MSAGAYDRHITIFADNGRLYQVEYAFKAITAANIMSVGVRGKDCAVVLSQKKVPDKLMDPASVTHIFQLSPSVGCVITGSIADARAFAQRAQGEAAEFRYKYGYEMPADALAKRLANISQVYTQRAYMRPYGVATTLISLDSEYGPQLFKCDPAGYYIGYKGTAAGPKQQEALNHLEKKLRNKEHAEGSWEEVVELAITTLSTVLSMDFKKGEIEIGIVGGPRPDGEEGTYSGFRTLTEDEIDDRLQAIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4B1</accession>
    <name>S0E4B1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable NADH2 dehydrogenase (Ubiquinone) 40K chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429624.1">
        <property type="nucleotide sequence ID" value="XM_023576386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4B1"/>
    <dbReference type="STRING" id="1279085.S0E4B1"/>
    <dbReference type="GeneID" id="35407128"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13674"/>
    <dbReference type="HOGENOM" id="CLU_007383_6_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000358">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="50"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="375" mass="42746" checksum="C1CB00B6FA234823" modified="2013-09-18" version="1">MASPLFAARAARKAAFNVAGKRYLSDISITRTGKPIMRVEGGRSSLGGHTVTVFGATGQLGRYIVNRLARQGCTVIIPYREEMSKRHLKVTGDLGRVVFIEHDLRNTPSIEASVRHSDAVFNLIGRDYPTKNFSLEDVHVEGTERIVEAVCKYDVDRYIHVSSHSANSQSVSEFYRTKGRAEEVARQLFPETTIVRPAPIFGFEDNLLLKLAGVTNLFTSNNMQEKFYPVHSIDVGAALEKIFYDDTTAGQTFELYGPKKYSMEEISVMVDKEIYKQRRHINVPKAILKPVAEILNKFLWWHTLSADEVEREYLDQVIDPEAKTFKDLGIEPGDIINFTYHYLQGFRSQNFYDLPPATEKEKREEKKYIHVLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5A5</accession>
    <name>S0E5A5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to ochre suppressor tyr-tRNA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432123.1">
        <property type="nucleotide sequence ID" value="XM_023579254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5A5"/>
    <dbReference type="STRING" id="1279085.S0E5A5"/>
    <dbReference type="GeneID" id="35399458"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05980"/>
    <dbReference type="HOGENOM" id="CLU_093897_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="159" mass="18075" checksum="F3E2B88A83836D3A" modified="2013-09-18" version="1">MGSSESKPISSHVWKASAPNGLSQDLVDSLQSSNETDASRSKIVELQIQARVAEELKKLQQKEAEALKIAHEKLASADFKDDNSTSQYTVSKEIEAMREKLESRKQVRPLPESVEGARNEVIRCLREHDRRPLDCWQEVENFKAEVKKLEKSWVEKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5X6</accession>
    <name>S0E5X6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432280.1">
        <property type="nucleotide sequence ID" value="XM_023579444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5X6"/>
    <dbReference type="STRING" id="1279085.S0E5X6"/>
    <dbReference type="GeneID" id="35399629"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06152"/>
    <dbReference type="HOGENOM" id="CLU_362105_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="772" mass="84788" checksum="1BAE23AD1FB0AD83" modified="2013-09-18" version="1">MSDGGDYEPSDDYDSSDEEFPPLPDKYAHVGKDSIESIMSNAKENRRHSKRLYSQLQPELKTQSATYNFHLWGNRFEAFVKSLGVKSGNTPTEAHLCRFIAVFPTTPRPPPDEGKKYSISTIRAAIPAVIKWCQVNYPDWKMTPAGDMKLQAIVNNHIDTEKVSTAPANQKQWVTTQNVRQLVSNYLQTGTQLGLADWDKAVLNVLCMVLLAATGARPGDVAKSPRYTTEYCLRWEHIVIARSSQTNRLIMTITIHYAKGKKTDPSGVIHHEFNELADASDSQLCIIKWLIVWALRTGVVRATSWAELKQHIDANPKNVVEWLLPNRPVLCCCIRGGMSKLDFDKPLIAEHISSKISQICALTPSAPKIIPYDLRRGAAFEVANLASESQSAGVLAGEAAAALLLGHGARSVTDGVTRRYIGNFGRDEWTPRVKAVNTHERAGQRLVLLESPANTPAPRPKRLTTEAVTEACKRAKVDPSDVNRRNVVKQRMRAQQRNDARDAALNSARTTLSSKPTSSAVVHTAVAPTVNPAFSPAFNSTFSTAFHPAFHPASPAFNPAFNSAVNPAVNPAVNPAVNPWFHQAFNPMFNSAFSPAFSLAFTSAFNPNFNPVFNAAVNPEGMGLAGNPAVHSDPTHQDGENIASDKVTGLGEESVSNETGSENSQAASVGIVPQSPLVLESVTTPWLAEADVFIEYFSRINVYHYSGTRNDALPYYVVSGGSRDPPTRFFMRCKNHPLCDFATPNKTSLQTHHQRCMKPLNGGMQPWSRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0E659</accession>
    <name>S0E659_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431292.1">
        <property type="nucleotide sequence ID" value="XM_023578492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E659"/>
    <dbReference type="STRING" id="1279085.S0E659"/>
    <dbReference type="GeneID" id="35407744"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14292"/>
    <dbReference type="HOGENOM" id="CLU_019783_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="441"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="763" mass="85263" checksum="CE53C8BE7074A085" modified="2013-09-18" version="1">MADHDIIHSFKSTIASNLQGSYAQVHVLLIAWETHDLGDVDGEIRDLRAIFEQDYRYSSVVFFQIPIRGPSRARLNREISSFVEEQSFPQESLIIIYYAGHCSPNAQGQAEWAAFERGGPTVSWHVTQQLLFSAPGDVLLILDCCHASLISRGSKDGDGRFELIAASAKGAKTPIPGRRSFTRALIRLLRENSSTGISSESLVSELREDPKVTGKTRNLLMGSQASIYIQVETPVFHDFVRKSPTKIFLQPLQPTAATEGFIKKPSGYLVFRASLSDDVTGLQIATWLKTAPPKNVTAVSIEAIVSRARHIQDALKDGAFPQGSIFEQLSKPARDEILKGIRRLNTIMATTAEYAKDDTIRNEGQVIQQSLVDIHDRVSTLSTAIETPLLLDTGSSRSPGSTQETPGVGLMAAVDVDATLHLRDAIMSQDPSSYIREISRDKIFESLKRSSSTDMLSSRFKLGSVDGRFVIMETFKYRESEDNSGEPQPQTLTQVRRITGLLCHPKRKGFQILPCAGFFRDRLRKELGIVFWSPPLFGAGSKVATLLQLYKMHRLVPLGQRIHLAWAVATAVENFHRVGWVHKGIRSDNIAFTEVVPSPESDLNEDDADSPVTYRFDFSKPLLFGFEYSRADDDATYLEEDYSLNNNLYRHPDRWGRPRTRFEKGHDVYSLGVVLLEIAQWKEASSILKSLLDTKPLVPSDVAKALIGKCGKSLSHQVGRVFAQCIVTCLDFPMRTKSMSEYEMQRYFQQNVTELIGRAVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6H9</accession>
    <name>S0E6H9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_06467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432568.1">
        <property type="nucleotide sequence ID" value="XM_023579796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6H9"/>
    <dbReference type="GeneID" id="35399944"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06467"/>
    <dbReference type="HOGENOM" id="CLU_114609_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT70489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="124" mass="14036" checksum="A55EF7A0443B4EDC" modified="2013-09-18" version="1">MSLTDETSPVEQLFLDRSIHDVLTKKWPAVEPWATIYVDAIREQRFGDAVWARYHIEGNVENGVIISPSPSDNMPVLDSIREDAEEAKMNEPEFYAKALQFYAKASPSDGHPEVIKIIFEADKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6X9</accession>
    <name>S0E6X9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to putative cystathionine beta-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_06548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432645.1">
        <property type="nucleotide sequence ID" value="XM_023579885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6X9"/>
    <dbReference type="STRING" id="1279085.S0E6X9"/>
    <dbReference type="GeneID" id="35400025"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06548"/>
    <dbReference type="HOGENOM" id="CLU_018986_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT70566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="425" mass="46847" checksum="83C1C49B885CBE60" modified="2013-09-18" version="1">MSLNKEGPDIAESLRKTFNMASNNFILTAEAHSEALPNFHFSTQAVHADDFVSPHRAIAPAMHSAVNYRYARNPDDLVEMENDDPNAPFDSHVYSRYTAPNYNRLEIVLKTLFKNPVVSYSCGVAAFHSMLVAINPKKVFISDGYHGVHAVIELMAKLNGLKKLSLDDLDQAGPGDMIHIETPLNPTGEARNLAFFSKKAKETGALLTVDATLAPPPLQDPIQFGADLVMHSGTKYIGGHSDMLCGIVIVSPQQVKSGLEQTLRDERMVLGNVMGSLEGWLGIRSLRTLHLRVMRQSQTAEALVSWLNTGLSDSSSVIGRIVHKIAHSSIQQDAEWLKGQMPGGHSPVFSLWLKKPEHAKRLPSKLFIFQHATSLGGVESLCEWRAMSSRGEDQRMLRISTGVEDLEDLKGDLMQAFEALLAEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0E751</accession>
    <name>S0E751_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to myo-inositol transport protein ITR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_06666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432755.1">
        <property type="nucleotide sequence ID" value="XM_023580018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E751"/>
    <dbReference type="STRING" id="1279085.S0E751"/>
    <dbReference type="GeneID" id="35400143"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06666"/>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="123"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT70676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="617" mass="68412" checksum="AC0088D26EA873EB" modified="2013-09-18" version="1">MDDKDISPGHGGSSYDDKTVTPPPEKGGAEILEHASQGRRQSVALNIVQNPLQSKTQDQVVADARAFAESNGMSEHVDLFGRAALIARDPDSFESVDLLDDERAALIYERDHKWHGSKMLWYSIGLCAVGAATQGWDQTGANGANLSFPKEFGIDGEGRDEWIVGIINSIIFLTAGLIGAFIVDPLNHYFGRRGEIFITACCLVATPIASGFAKNWQELFAIRFIMGIGIGAKNATVPIYSAEMAPARIRGALVMFWQLWVVIGIFLGFCANVIVKDIGDIAWRLELGSAFIPAFFLAAGIYFCPESPRWLMKHGRIADGFVSMSKLRAHPIIGARDYYYSYVIYHEELRENAGAGYFARLWDCFAVPRIRRANYGASTVMLAQQMCGINIISFYSSSIFREAGYSHDEALYASLGYGAIQVVFTIPTLFLIDTKGRRFLTLATFPFMCIFLLAGGLSLLNDSDNRAANIGPVVLFVYLFTIAYCLGEGPVAFQYSAEVFPTIQREQGMAWAVCINNTFAGVLGLTFPRMKTVMTPTGAFGFYAGLNLIAWGMIFCFVRETKQMTLEELDQVFSVPTKSFLSHETKVWLPYIFKRYVLRKNIQRPPPIIEKGEKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8F6</accession>
    <name>S0E8F6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_08777</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433253.1">
        <property type="nucleotide sequence ID" value="XM_023580483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8F6"/>
    <dbReference type="STRING" id="1279085.S0E8F6"/>
    <dbReference type="GeneID" id="35402253"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08777"/>
    <dbReference type="HOGENOM" id="CLU_049331_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="80"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT71174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="268" mass="30454" checksum="B71ADA7A7164C691" modified="2013-09-18" version="1">MASTSKQPPKGILKKPKSIKERNADPREIAIEHAKIIQHRKDLEAEILDSLVLLSEYPLVREQPYNASNPSPSDVADFKAHVRLFQPSDYDDLVIERNVNELCGYTLCSRPRRNTGPGGQWKISNGNIMKREDLEKWCSNQCARRALYVKVQLNETAAWERAGIPDIEIDLLDEDKSKETEVDRAARELGQLKLEEQRQAARDEAALALERGEPDASQSKSKKMNITLKENDPKAPSAAPDKPEVYDDEHLLIEGYRTKLNLEDKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8J2</accession>
    <name>S0E8J2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_08743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433285.1">
        <property type="nucleotide sequence ID" value="XM_023580521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8J2"/>
    <dbReference type="STRING" id="1279085.S0E8J2"/>
    <dbReference type="GeneID" id="35402219"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08743"/>
    <dbReference type="HOGENOM" id="CLU_023703_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09245">
        <property type="entry name" value="BRO1_UmRIM23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.280:FF:000005">
        <property type="entry name" value="pH-response regulator protein palC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT71206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="478" mass="51982" checksum="D2699694E5A9CD28" modified="2013-09-18" version="1">MPFPFILPTTSAFSFSSSFSSESHPSLPLNASTYRGVVRDALKKHKRLPPSSQVSNLNTVISSVNGYIPYLLAVDDGLSNEGLSIVTQKTPPAIEWRPTLSGEVVPGRERARVKISSLEHEIAFVLSTLGFSHVLTARSALQPLYSTSSEFLGAQERTNAITTATKCLLDAASVYDYLAGRMEHATATSPCPDVAPGTARALCSLALAEATLLAVLKDDPYPAIVAQDRNKNDKEWMFKAPEIPKVRAHLYARLCLAASEHAAKASSLCSTAGSGSHKINSALLKYLEDLRRTCRARACRFFGIDAEIGGQVADGIGWVRAGLSELGVEIKDNKKGLSFSRLKKDFTEKREDRRVDKESAWGSDAGKMEEIRVLEMLDAKWNKVNDTMNTQAIPPINTLLSKMPSGREIHTLKPYEVPSLDRDVLEAMRAPPEDDDTYVDDLSSDDDIKGGPSAPVGAFPGTVDDYARSPSTPGNAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAV0</accession>
    <name>S0EAV0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433864.1">
        <property type="nucleotide sequence ID" value="XM_023581225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAV0"/>
    <dbReference type="GeneID" id="35401587"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08110"/>
    <dbReference type="HOGENOM" id="CLU_012769_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="964" mass="108029" checksum="3A9DD184A32F5359" modified="2013-09-18" version="1">MLLSSNRNDLSPESLQQSPVDTSLEFLDGDAMSSEQLLECYQTGKECAHPAVSFDVTTSHHPDRMDRPEGASEVSFASSPSNPRGPPTAGYALTRESDDRIPRPTSVHTSTQLQKLPLVFAVEVSSTSERIFQQEKNTISYIASKLEPKELADQSYILPWDRQAHDPVPTNLIGDLQHSVGSNPSSIFDNRLGRKRLEQSKIWFLMTDGVIEEERANDFTNKIAEAGLHGTPSVIIVFGNRSRPPSRSKLSIGMSICAPSPHCAVLFHDVWSNEPFIVQAKGCFASLLPKGSYFKWFSGSKWTDFPQTSYDRLLRVRVPQSIRLSKDEVALPYSRVFDMKYIYNDSMSDQDKLQLLSNNSALDAIMVVARTRGEGFLVKLWIESLRRTTRRESLTIDRDDVDSRGLTAMRFLLMAAEQELKAPNTRHKDIWSCLTCVAPPRCSRSMQVHGTSHLDFHRASVRLQNKRNWASFEAKVEMERAALMRVTKGLQEVQSAIEILDDPLPNDPSLATADTFWYPASGVKTARDNEKLPASVLPKKLDKQDVDKSLFLSGFKGTRKLEKAAQSRAYATCPICREPNSIQALLLRASPKENKTPQLPSPNQMLKLTCPLALGNYPEVDIILPLTCCDGCAFLLLRTNKQATTTQTSHQVAAALPLVSLQDKQNRRLWRQTLAEVFRHRFHDSDVLSIFLATICTEIENVPSLTRSKSLKWCRDELSRLPGIHVPQSSSPKLVTSLPSAVDNIVPPQQVAFFACLGNKFYLKAVLSQPVEGFVVLVQLATSMNVVKPEAIRNLVWKRLLCHFIEQDLRLRTNFGMKYAYTMLQEIIQQSPSSSHGHHGKFVIALPKQRTSISLTSLVNTYFIPPGSSAISHFLRIPCFEESYSTTEYNAALAMFLHLLASIEYHGEEATDVLEEMKSVADKLRDVGEDVRSVFEDPTSVDESGSAYAIAHLESWLNFTVPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBB7</accession>
    <name>S0EBB7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_13812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434262.1">
        <property type="nucleotide sequence ID" value="XM_023581586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBB7"/>
    <dbReference type="STRING" id="1279085.S0EBB7"/>
    <dbReference type="GeneID" id="35407266"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13812"/>
    <dbReference type="HOGENOM" id="CLU_023194_19_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="134"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT72184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="362" mass="40153" checksum="D7ABB1F9849F17AE" modified="2013-09-18" version="1">MSGKTFNVGVVGYGMSAKIFHIPFLTQTPQFKLHAIVQRSPKEGNSAPADYPDIKHYTDYKDLFADSAVDLVVISTPPNNHFELTKAALEAGKHVLTEKPFVPTSAEADKLIEIAKKNGKLLIVYQNRRWDADFVTLKKIISEGTLGRIVQFDNHFDRYRLVPSKNWKLDLPLSQGGSALYDLGTHLIDQAYVLFGKPQSVHGRLLSQREGKFDFENPDGVSAELTYPDGLLVNIRISVLSAELEQPRFWVRGTKGSFRKLGLDTQEDALKAGAKATDADFGKEDPARYKLVVVDDNEKAKEQTISSIETPTYKAFYAQLGKAVESGKEEDVPVKASEARDVLQIIEGVFESAKTGKDVTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC27</accession>
    <name>S0EC27_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CI-23 NADH-ubiquinone oxidoreductase 23 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_12378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434579.1">
        <property type="nucleotide sequence ID" value="XM_023581977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC27"/>
    <dbReference type="STRING" id="1279085.S0EC27"/>
    <dbReference type="GeneID" id="35405834"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12378"/>
    <dbReference type="HOGENOM" id="CLU_067218_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT72501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="215" mass="24520" checksum="3AAF4319E9F722C3" modified="2013-09-18" version="1">MAHALIARRQLASAATSRASILGLVQQRSYATPHGPPPANFRTSKPVQWTWDRDSTLDRMGKFFLMTEMARGMYVLLEQFFRPPYTIYYPFEKGPISPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEERADGSRRTTKYDIDMTKCIYCGFCQESCPVDAIVESPNAEYATETREELLYNKEKLLSNGDKWEPELAAAIRADSPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC34</accession>
    <name>S0EC34_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_08570</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433446.1">
        <property type="nucleotide sequence ID" value="XM_023580713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC34"/>
    <dbReference type="STRING" id="1279085.S0EC34"/>
    <dbReference type="GeneID" id="35402046"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08570"/>
    <dbReference type="HOGENOM" id="CLU_038298_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT71367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="284" mass="31915" checksum="A72A690D2B739CBF" modified="2013-09-18" version="1">MHLSPAMALPYIPSRTSTKPPNSKPRQKQETPASAPAPRLLPGERRVKPRLSRPSLDPVLESDQRLSREVEQIASGDAAKVTRKQSLPILTRNRSEFFEEAFGPKHTQDPSDRIRNESPVLVEIKTNVIASWRAIEDEFTFITELSEYFSLRYNRPASSIVITVQHGICIQFGGGSDACYTMTIEALARDVQTTTNKRNIALFQRHMEQALRIPPSKGFLRFVPLAEDCAGWKGNTLAGHITEVIEETQAMAERRGSIRAPRRRSSKVSLVYCYVEGAGFDQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EC73</accession>
    <name>S0EC73_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434318.1">
        <property type="nucleotide sequence ID" value="XM_023581653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EC73"/>
    <dbReference type="GeneID" id="35407205"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13751"/>
    <dbReference type="HOGENOM" id="CLU_116365_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="215" mass="22227" checksum="78401A3E79819E23" modified="2013-09-18" version="1">MSTKNPSHGQKVSIGKPRVIPELTDQVDLGQNAPVKEEGAGTVPNESLAAESLKEGGEFASNEGIHGENQPTSGSENTSAGRNTETSSAPSFGSDSKAKAKSSSSASKSSGTASQSSDSAPKSLAGTAPSYVDNQYIKESGPHGKNLKEGIDYSNTKDGLKKALESEPGSQDDPSRLAEQQFQQNQTAAGRDAGPKQSELEGKTPFDALKNEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECB6</accession>
    <name>S0ECB6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434597.1">
        <property type="nucleotide sequence ID" value="XM_023581997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECB6"/>
    <dbReference type="GeneID" id="35405852"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12396"/>
    <dbReference type="HOGENOM" id="CLU_1111481_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="250" mass="29513" checksum="FEE9D1A3B04C2053" modified="2013-09-18" version="1">MEDDIPEGYRPDPPGNIEAIWHKSHTPIFDLYPYPNNKSPIVPSTSKLDEDWLLAATSRARIFKTLSSSPNIRECKDEHIQFFFWTALDRSNRRYKDIHSPNAQLWDFHDMHETQQAHEDGLWRDVLLSSPWFDCPIFDDLLHKPQIRNDPGGEKHRKVRVVKRNPHFVELEDEFLERWWLKAAKLKLRRFDNGDAVLPITAQSYMDMYGEKAMKWDIEEEDDESDEVTETAIGEVMQREDEDADDEESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0ECX8</accession>
    <name>S0ECX8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to LIP2-lipoic acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_06206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432332.1">
        <property type="nucleotide sequence ID" value="XM_023579505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ECX8"/>
    <dbReference type="STRING" id="1279085.S0ECX8"/>
    <dbReference type="GeneID" id="35399683"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06206"/>
    <dbReference type="HOGENOM" id="CLU_035168_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="99"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT70253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="338" mass="37413" checksum="3500214F0307ED33" modified="2013-09-18" version="1">MPLGLRLKAIPSSAIKSTSFRIGAGTSAGHVFFNRWSSTYATPTSELPSLNLLVHRHLTGSDPDAFVPYDTANNEQEELRSLFLEWKSLSEEQQQDRGHIPRPHLLSFEPTPTLTLGRRQRPLTSEQTSYFKSPLHVGLPHRRNPVNDQSFIPEVKQTSRGGLTTYHGPGQLVLWPVLDMHSPLYAHYSVMSYANHLEATTRRLLACLFGLETYTTRDEPGVWVRTPAGQPERKIAAIGVHHRRHVTALGIAINIDVSVDGPDVVNPWARFVPCGLEGKLVTSVAAELAMKDGIVRLGGWNTASLAAVWAKIFEEGIVDDTKRSIDGEGSSQFRRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDB7</accession>
    <name>S0EDB7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_08738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433911.1">
        <property type="nucleotide sequence ID" value="XM_023580526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDB7"/>
    <dbReference type="STRING" id="1279085.S0EDB7"/>
    <dbReference type="GeneID" id="35402214"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08738"/>
    <dbReference type="HOGENOM" id="CLU_015255_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF1">
        <property type="entry name" value="FH2 DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT71832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="604" mass="65728" checksum="44D30A896C062B80" modified="2013-09-18" version="1">MSGYGYGPPPPPPPPSSGGTSSYGPQAPSYPQHGQGRGGHHGRGRGGHYNGGRGDYHGSPQGHYEYNGQPYPPHHNPPPYGAAHPPAGSYPPQPQWGPEHGHPPHGHPQGSMPPGNYHPNYPAQPYPPSQYPQQPPYGAPQAYPYQGPPPPNQTQWSGAGQPPGGPYSSNGRGRGGYNDRNGPKPPLNGPVRPGYEHEAMPPVNGYGQPYPHDPRAVHYPPPQYPAYPGPPLPPGHHQDGYYGHNNRRGRGGFRDGNARGRGGHHGNDKSRHQKHGNNDSAHHKSETPTLGKKKKRKTNTLGLTPGMDSESEDDEGEEKVLTDLIGQETLNVKDVASFLAERKKHFPTKARVEAKKTAELAQNGEDKASSLEKQADKLRRQLRKVESSIKRKREQGDEGDEMRDPSEESSDDEPEVMSTRAHVAPPPPPPAKKADVSKHCKYYSTGGTCGKKGKCRFVHDPEVREAAMKDREANNGRLTIQQRLILNDKEQEDLTVLQSIQYLRKKGLMQPEEPEEPEVKKEIKPVAADLPAHPPPSSLLPAASASLPPPPIKREPNLPRHNPPPSIIPSANGNSTQGVKPYQGWNLRPYGSTGGKSSKSDDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>S0EF21</accession>
    <name>S0EF21_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to general repressor of transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435624.1">
        <property type="nucleotide sequence ID" value="XM_023568423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EF21"/>
    <dbReference type="STRING" id="1279085.S0EF21"/>
    <dbReference type="GeneID" id="35403119"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09651"/>
    <dbReference type="HOGENOM" id="CLU_014909_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="689" mass="74138" checksum="6C0DDBFF2F9B14D3" modified="2013-09-18" version="1">MSSGVVRSTALRAGGACVRCRKGKTKCVYENGRAPCKNCAKGMHDCYLPSESMAHHHGQSPARHANPHRPPRDSLPAAGPGVVAEARQPVVGSSAARHIQTGSDKLTPELIAECERVVSKTFPACVAFHKPSFVQQLKSASLDAALVYGLLTCAARSSPSLIRRYGGPTQAAETFAAKAMTLINQNLDHPNLVDIQALCLIIIHEWGSRNAVRAYIYLGQAARMVQMYRILNSHHASPDGDMFLRDESLRRTVWLIYILDCLLTSTPGRFAALSPLDTADVPLPCSDINFAFGNAVFVKTLRQQLDPTAIPPGQPPSEIGEFGYIVLASTIWRDVVGMLTTTTLASFREEDCGDLIAKIEGLRASLPMQFVDKPGQINLHMTMGSGYTFAMLHCLLHCATIFVHRRRLLQEVTSVNFNLESFRLNARCHDIIDRLFTSCHGTISLLTAVEAGSEKDHTPCFPIFMLFSAFTASATVAYLSLKGLTPPNAVETAAHIVKDGLRFMSDGTENWPLMGSWLRHLTVMQRVLNNDAAAANGGSLRHGSTSHGAGVKDEISSNADTNPDAMDYDQQTNHAGSVSGQGNPRSISESVRGDSEPPVVLARRPGVTTINGSGGASTPTTVSPPPSNTTHGAVPDIKQQPSPEMANGIVPPQDGQTTSQDMTAPELCQAFERQLLDLDDLAAFMGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFL2</accession>
    <name>S0EFL2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to nicotinamide mononucleotide permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_09668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435607.1">
        <property type="nucleotide sequence ID" value="XM_023568403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFL2"/>
    <dbReference type="GeneID" id="35403136"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09668"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="498" mass="55683" checksum="8F30E966A2C6A967" modified="2013-09-18" version="1">MALNHTEKEEGNESPVSLDPERSHLRDAVHTDDATVVCPSSTTDTKLMTKIDLHVIPFLCIMYLLAFLDRVNIANADVFGLSEELGLEKTEYNTALVVFFVPYVLFEIPSNILLKRFKPHVWLSLNMFFFGLTTLLQGLVQNYSGLIATRFFLGLFETGMFPGAFYLIGMWYRRHEAQRRYSFFFNSTTLAGAFGGLLAAAIGKMSGMRGYAGWRWIFILEGGLTVLVSFFFYFLLPDFPEQAKWLTSEEKHYVTARLRIDQGHAGAERRTTFADALNVLKDYKIIIGGFMYFGLIVPAYGYAYFAPGIIKTYGYSPIQTQLYSVPPWAAAFGFSLAIAFASDKLRHRASFAIFAILVAITGFAILLAVHDNHSVQYGALFLVTMGAYTAMPIIVCWFNMNLGGHKRRSIGSAWQVGFGNIGGIIAVYAFLAKDAPKFIPGYSICIAFTVVSIIACLSYASVILYENKKRDANPPQTELTNEEKAELGDNAPTYRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFZ2</accession>
    <name>S0EFZ2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumonisin cluster-short-chain Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435999.1">
        <property type="nucleotide sequence ID" value="XM_023568871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFZ2"/>
    <dbReference type="STRING" id="1279085.S0EFZ2"/>
    <dbReference type="GeneID" id="35402718"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09249"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="367" mass="39431" checksum="C533A9BDFD49BD61" modified="2013-09-18" version="1">MNGGHDLVLLTGATGHVGYAVLVKILQAGYNVRVTLREMSQADAILSSGLVKEALSCGKIDISFVHVPDFTAPDAFGSVLSNVTQIVHVASALRRGPSRDLKGAIIDVAVMGTKNILRAAQNCPSVRRVVITSSTSAIVDPHPAVNQSPTGRCITPSDRHIDYDAEYYRGNSHKAYTAAKTAALNATDAFLAAAGGGGGTSPLHFDVINIMPSFVFGPKGLAASPADIINGSNIFGIGTVMRHKSWKGIRLEAVCCHVDDVAQIHVNALDERGLLPLKPGTHRDFILGVKFKPEDIRQVVKSRFPIEFWENESAVFGAHGTYEWYHIDYDVRPAEDLLGKPFKTLGEQIYDSGSQVLGMSKGLMTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGL0</accession>
    <name>S0EGL0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435040.1">
        <property type="nucleotide sequence ID" value="XM_023582515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGL0"/>
    <dbReference type="GeneID" id="35406316"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12860"/>
    <dbReference type="HOGENOM" id="CLU_1768150_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="147" mass="16088" checksum="02D76C52DFF6B443" modified="2013-09-18" version="1">MANLIDPSTTKLVLIVSLLWIISFTLHTHYEINDIIFYSVAIGTSFVLATASCVCLSGLAVIAVYFSVLANAAILCIIVMLIPVLQYLLQCISSLFTGIKNLCDRVIGFCDAVFGFLDNINTAVQLFPPSFDRFLYGPEGLEPLTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGR1</accession>
    <name>S0EGR1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435923.1">
        <property type="nucleotide sequence ID" value="XM_023568780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGR1"/>
    <dbReference type="STRING" id="1279085.S0EGR1"/>
    <dbReference type="GeneID" id="35402799"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09330"/>
    <dbReference type="HOGENOM" id="CLU_031468_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000609">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF40">
        <property type="entry name" value="REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14497)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="190"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="325" mass="35677" checksum="EE7E0AAF91AD6F81" modified="2013-09-18" version="1">MSDKPLEVLVYGLGAIGSFYAFILSRSEHVHLTVVARSNFEAVSANGISIDSQNHGKHRVKPHKVFRTVAEAGQKFDFIICTNKAVDQLSTAGDIAPGVGDDTSIVIIQNGVGNEDAFREKFPSVTIISCVTWVGARQPEPGFINHTTSEDMQVGLYPNKAGDASRDAQHLSQFESLLSIGKTIFQIVPNIQVQRWEKVVWNAAWNSLTALTLMDTHAWLSSSDLSTPMTRKLMKEVIDVANALGVPLEYGLIDRLLDKILAMPPIGSSMRTDYENGKPMEVEVILGYPVKKGRELGIDVATIETLYTILLAINKRLISVQSKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH36</accession>
    <name>S0EH36_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_09199</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436043.1">
        <property type="nucleotide sequence ID" value="XM_023568926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH36"/>
    <dbReference type="GeneID" id="35402668"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09199"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT73965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="528" mass="58511" checksum="908EC97FCC37E7E4" modified="2013-09-18" version="1">MPQTGNQTSLYNKLVITFVAIGGTTYGYAASIIGSTIGQPGWYQFFNLPADGQPGYDTITTPAIATANGLFSAGGAFACLVLMWACDYYGRLRSIQFGCALGILGGILQCAAQNLAMFQAGRWIMGMCVGLMATVTPMYLSEMSSPLARGWLVGHHAIFLVFGYMLSSWIGFAVYFSKNLEFGWRFPLAFQVFPPLVLLLGSPWIPRSPRWLMSKGHREEAWSVLVRLRRSASDPEDLVAKEEYYQIEKQLELDAKKLEAYGGNPWRAVVQKKSYRKRMLIGFMTQWGAEFGGPLIINNYAVILYTSLGQTGYMPLLLSALWLTTAGLIYNPGGAWLHDKVNSRRKMYMTGFIGIVITTSIYCAMISLYAGTDNKAGNAIGVLFMFLYLAFQGTFCNTTMYLYVSEIFPTEIRSIGIGWSLFGQFAATIILLQTAPIGFNAVGWKYFLLVICWSVLFIPAIYFFWPETARLSLEEIGKQFGDEVAVHITDATDEERAAIDRQLMGEIHGDNKAPANAANEIPSSNSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH46</accession>
    <name>S0EH46_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_10394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436424.1">
        <property type="nucleotide sequence ID" value="XM_023569172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH46"/>
    <dbReference type="STRING" id="1279085.S0EH46"/>
    <dbReference type="GeneID" id="35403859"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10394"/>
    <dbReference type="HOGENOM" id="CLU_023880_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT74346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="588" mass="64871" checksum="0B1A53FC9F84FF8F" modified="2013-09-18" version="1">MTTRSEQACKACKKQKRRCDKALPECSLCKRTQRPCEYGIATDFQPSASDWSMMQARLSELENRLANSPRATEQHILSPISGPASGSLLEQESTPGAMFCDIDTHSIVSNSVNSWSQPTGFTPSYSTAECSDSTSVTRFPASMFLDIDCYVWSQAKLPVPSGAIPAPVLALLSQGNVVLDVSQNYFATIHVWFPMISKKRMDMGLPVQNAGPDLAMLFLGMKLITTPAIDITDSTLYDTAKSFLASLESNGVVSLLCLQAMILVALYEYSHAIYPAAWMTIGSCARYADILGITPGDYSPLGQVTTWTEAEERRRVWWTIYILDKLVSLGSRRRCLLLDIYPECKLPVDDDAWDRGEVNMAVSHSTSISHQLQQSPFARLCQASMYLGRAISYARDNSAMTTSRAEEIMSLANELSDFGATVDNEATATGPEKRIILLAPRSIAYSALFVALDRFTCPEKISAEPGYVDSPGDKTQDEIELQRQSMHIIEQISEQLHTLGMDLLPAFRTDGISSLSKVSPFMLDSIYASAATFHWLLGEGGNEVYRMAAADLGMFLDTISSRWRLGGTYREMLTVHDVAARVEARTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EH48</accession>
    <name>S0EH48_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to Chitin deacetylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436053.1">
        <property type="nucleotide sequence ID" value="XM_023568937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EH48"/>
    <dbReference type="STRING" id="1279085.S0EH48"/>
    <dbReference type="GeneID" id="35402658"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09189"/>
    <dbReference type="HOGENOM" id="CLU_029940_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="77"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="328" mass="37870" checksum="62EA2C3832007609" modified="2013-09-18" version="1">MPTTFASHPNYGYDRDFKGYGEKGLVGLKWPNNAKIAVSFVINYEEGGERCVQSGDGVSETNLREHPTLPRMNERDLNGESEYEYGSRVGFWRLFKLFNQHKMKFTLYAVAQAVEQQPEVATRCVEEGHDVASHAYRWVDHHDWSVEKEKDYIKKGITSLKSLTGYAPKGWYYGRPSPHSRTLIPQVYEEMGEELVWASDTYADDVPYWIDLPTEREKPDPKGCLMVPYSYDCNDFKFHVVTGFRDSTSFYIHLKNAFDVLYEEGEAGEPKMMTIGLHCRIIGRPGRFKALKDFVEYIAQKEGVWVATRTEIAEAFREQFPYKKGELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHC4</accession>
    <name>S0EHC4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_10066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435330.1">
        <property type="nucleotide sequence ID" value="XM_023567961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHC4"/>
    <dbReference type="STRING" id="1279085.S0EHC4"/>
    <dbReference type="GeneID" id="35403533"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10066"/>
    <dbReference type="HOGENOM" id="CLU_031812_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF8">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="192"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="413" mass="44633" checksum="C2D44B8E9FC82BEA" modified="2013-09-18" version="1">MTLLSKPSISMEDVRNTIDTYIKGLSDDLYILNKQIHDEPEIAFQEFKAQTHISDFLERQGHAVQRGAYNLPTSLESIYGSKGRCVNFNAEYDALPGLGHACGHNLIATASIAAYLALTHTLNKYGVDGRAQLLGTPAEEDGGGKILLLNAGAYEKADLSLMIHPFVEDQFRPNGTIGSAGQSSIAIVDLIAEFRGTSAHASGNPWDGINALDALVASYNNISMLRQQIKPDERIHGCILQAPKITNAIPEYTKVKFSIRSPKMNSLKKLTQRVRKCLEAGGLATGCEVEITEDLAYADLWVNNPLCSLFKGHMESLGISLSQGSQQENIGGSTDMGNVSQAIPGLHGIIGIQAPPGTFPHNHAFAEAAGTKEAYLRILEAAKGMALTAWSAIVDDKVFAEIQDHFDKDEQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHG8</accession>
    <name>S0EHG8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to hydrolase related to dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436312.1">
        <property type="nucleotide sequence ID" value="XM_023569042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHG8"/>
    <dbReference type="STRING" id="1279085.S0EHG8"/>
    <dbReference type="GeneID" id="35403742"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10277"/>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF55">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="251" mass="28056" checksum="E0CA10270F3050B2" modified="2013-09-18" version="1">MSDCCLKGFQWKAKPKGRNNTVAEMNCYVSGTNKDVAVIIVHDLFGWTFNNTRILADHLAQEVNATVYVPDLFGGEVIPTEILYDKSRMGEFDLGAFFKRNSKTVRRPELVRFAETLRSSFSRIGAVGYCFGGWAVFNLGAKELSLVDCISTSHPSFLEKEEIANIGVPTQILAPEFDPQFTPELKAYANEALPMTGVAYDYQYFPGLEHGLLSVETRVSRARGTEWKEPRMQYLYGSDSGFTGLDQSISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHQ4</accession>
    <name>S0EHQ4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436253.1">
        <property type="nucleotide sequence ID" value="XM_023568973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHQ4"/>
    <dbReference type="GeneID" id="35403682"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10217"/>
    <dbReference type="HOGENOM" id="CLU_035152_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496042" evidence="1">
        <location>
            <begin position="20"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="514" mass="58058" checksum="FA0C968C7F7279C0" modified="2013-09-18" version="1">MKFSLILAPLVLLSDVVSAQSSLTDICTGSANNGCKTTITVPNGFKIVKSSKNVRSIQFNYIKVNICDQLRKALGTTLGNKFLKARDPICNCFTKLRTLNSEGKFTSSSAGNFDLANNYYLDQAGTLEKCLTDGGLKYSQSRDATLNKLKATGWQVVLGADMARGTFRAMISVIHPCRVTGVCNSEQIYAVFSNYLTASYKLLLGPIIPILNRWRDNLDLITKSTGYVMTATDNVKEAFNEVEYILSGYYDSICTEMDYCGSNRPNIRRFMTDVQIVINLSDKLSTGRQIFSFNTKTKSLLDDVNKLRSNWAYIPPANEMISKIRNNEIKVTKDVFKFMLVVGGMSTTSKKVATELGPLKSFVAEYLADSKALHELITRMLAIDWEKVNQGEFDNTDQTGYYVRNGLIAIQENMKKELAEAVKVYFWLIRATDSQLKDFTLTNGRWKMEYGTVEYQRWSTIDIDMPCTKITSTTAKKDGLTKTSNKYRTYWKCHFGPHTSQYQAVHVPYVRMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHW4</accession>
    <name>S0EHW4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to aryl-alcohol dehydrogenases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_14038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434046.1">
        <property type="nucleotide sequence ID" value="XM_023581333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHW4"/>
    <dbReference type="STRING" id="1279085.S0EHW4"/>
    <dbReference type="GeneID" id="35407492"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14038"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT71968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="349" mass="39269" checksum="CD359AA6D4F231CD" modified="2013-09-18" version="1">MFGDISVGESHHHLVPSSQVPSEWNTLGLKISKVILGCMTFGSSSWQGSPWVLDEEDGLKLLKAAYDQGINTWDTADTYSNGESEVIIGKALKKFNIPRQKVVILSKIFNPVMDDGTRPASINDGPLVNQMGLSRKHVFHAVDKCLERLGTDYIDRETPPEEIMRALHDVVQSGKVRYIGASSMYTWEFARLQYIAQSKGWTPFISMQPFYNLLYREEEREMLPFCEATGVGVIPWSPIARGLLAKPLSSKNDEANQSIRSQSDKKTETWFADANLEIVNRVEKVAADKGISMALVATAWVLQKGCYPILGLNSEKRIKESVEALNVKFTKEELEYLESEYRPRNIQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIF6</accession>
    <name>S0EIF6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_13836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434241.1">
        <property type="nucleotide sequence ID" value="XM_023581558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIF6"/>
    <dbReference type="STRING" id="1279085.S0EIF6"/>
    <dbReference type="GeneID" id="35407290"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13836"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="34"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT72163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="466" mass="50443" checksum="2732AC95F1F44CA7" modified="2013-09-18" version="1">MTTPYNGTTDHADYGYSTHVHDLNIFYDTGNLTFLAVSAVLVLLMIPGVGFFYSGLARRKSALTLILLSMISVAVISFQWFFWGYSLTFSRTGNSFLGDLTQFGLMDTLAQPNGSSALPDILFCLYQGMFAAITPALAIGCVADRGRILPAIVFMFLWSTIVYDPIAYWTWNANGWLFNLPSYDFAGGGPVHVSSGTCALAYSLMLGKRTGYSNNNGLPYRPHNVTHVVLGTVFLWVGWFGFNGGSALAMNIRAVMACYVTNLAASCGAIAWILLDYRLEKKWSTIGFCSGAISGLVAITPAAGFVKPWAAVIIGICGGIFCNFATKVKFLINVDDSLDIFAIHGIGGMVGNILTGIFGTKTIAALDGGEYDPIGWVDGHFVQLGYQIAGTLAVFAWSFTLTCILLFLLNLIPGLSLRVSPEEEELGTDDGQLGEFAYDYVEMTRHMADSTHPHSDASARTSQEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ01</accession>
    <name>S0EJ01_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_10832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436842.1">
        <property type="nucleotide sequence ID" value="XM_023569660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ01"/>
    <dbReference type="GeneID" id="35404296"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10832"/>
    <dbReference type="HOGENOM" id="CLU_1042247_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT74764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="267" mass="30536" checksum="DE09C4F618AEAF1B" modified="2013-09-18" version="1">MSQSALVSQGVGDPFQHLASEIREMIVTYLDCYENLDSLCLASPIMRKERQTSTLLLTSEYLERIFGGTHDGAFIEAHIYSLLSKYGLSEENFALWKKRKLPHPLFSSRQDIVFRMNALYHRLMDCFNFGPEIVPWFIKKLPYSVFAHYAAAAFGRNGEKFPISLHDATNAEKGQVFFFLIAVNMAGNPYIYEHEASRRQYCEQDLGLKGQDFVVCKPNFPISTKEGANARSFMQDVMGDAHRVEVHGSRTKSLIDRRRFRNDGILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJM3</accession>
    <name>S0EJM3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to PCF11 component of pre-mRNA 3`-end processing factor CF I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_09856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436115.1">
        <property type="nucleotide sequence ID" value="XM_023568194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJM3"/>
    <dbReference type="STRING" id="1279085.S0EJM3"/>
    <dbReference type="GeneID" id="35403323"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09856"/>
    <dbReference type="HOGENOM" id="CLU_015606_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021605">
        <property type="entry name" value="Pcf11_Clp1-ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11526">
        <property type="entry name" value="Pfc11_Clp1_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="4">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="VHS" evidence="3">
        <location>
            <begin position="43"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT74037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="602" mass="65791" checksum="74A2BB351BC8CE26" modified="2013-09-18" version="1">MSGDSAEVAEDYRMALEDLSSNMRFEISNLTVIARENTEHALAIAEVLQQHILKAPPNKKLPALYVLDSIVKNVGTPYTLYFGRNLFKTFMESYAVVDQPVRRKMEEMLRTWKEPVPGSMDSRPVFSHELVRPIENALLKARAVSMPQAGMMPGRPRSAVPHRDTPTPPGTRYPPGHPAQQYTSNGGQSLSNDIRNLIVATQAEASRNPQNVDVQTRLRALHELQGVVNSTSLPPDQLELIKRRVTELAAVNMMAPLTQRPAPTPPVPVQARPMPPVSVALPPSAAPAPAQEGVTLDALFGPGALAALMARKSATPSSSTPTPQPPQVRPEPPKPPLPNMSAMPAMAPIPAMSIPTIPGMTPMPTMSQAPAPGPAANAAPWSLLDQLRKSGLLPPAPSATPTPVPAQGGINVAALKQPCQPSLIRALHNDLGQPCTQCGRRFRDDPVGKKQKIAHMDWHFRVHQRTNEAEKRGMHRSWYVDQRDWLKSREAVDVDHLPTTEDVAAQASKASEAAKPKYILVPDASRRINTVCPICQDKFENKWLDTAQEWVWLDTVLVGDRAYHASCHAEATRDRENTPVLGKRKAETSIASPKVRSLKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJW5</accession>
    <name>S0EJW5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_09800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436235.1">
        <property type="nucleotide sequence ID" value="XM_023568258.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EJW5"/>
    <dbReference type="GeneID" id="35403267"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09800"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_8_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="799"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="848"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="947"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1030"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1066"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="103"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="439"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="804"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1147"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT74157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1391" mass="150552" checksum="781DCD5E1EFC8EF3" modified="2013-09-18" version="1">MASASPEQHHNAATSSDSASEPTRHDSTKADPATTETLIRALNDPTVERPPSHSPRPSTRSSAISAPSHTPPKKRKRSLRSFFIYFQLLFYANPSWVDILLLLVGTLAASGAGAPFPLMGIIFGQLVNDLNTASCDDGEIASQYSPKELQDSINEKVVMITWIGVISFALIYTYIVSWSIFSRRLENRIRDRYFMCILLQDATFFDKRQAGEITSRLNVDIQAIQSGTSEQVGIILGCTSFFVSSYVVAFIKNTTLAGILVSLVPAFMLLATVGSMFTAKFATAMTEKIASASSIASEVLANIPVVQAFGAGPRLEAIFAERMKGARKQGINKAFVAAIQAGMLYFIAYSANALAFWQGSTQIASMVEGNGGASVGDIYTVILLLVDACVVLGGIAPLLPLVGAAVGSFEKLREDMDSPAVIDTGSDKGEKLSSVEGTVSFRNVSFAYASRPHHSVLKNVSFDCPVGKHTALIGLSGSGKSTVAGLTSRIYDPPEGTVLLDGHDLKNLNVKSLRSHMSLVQQEPSLLDRSIVENIALGILNSPQPGHERFKATILGTGLTELAAKLRRGEYLATAAQGFGQDMIDLVHRVQEAARLADAACFVDRLEYGYGTLVGTGGKLVSGGQRQRLALARALIRDPKILILDEATASLDSASEHRIQMAIECIAKDRTVIAIAHRLSTIKNADNIIVMNSGEIIEQGNHLELMALNGSYASMVRLQTVDSEDAGSTTSTVRTDNIHSEKDSITDLKAKDVEQEVAEDSKEEIIKEKEAAPEGDAVLDSNKSAWTVMRTLSGMVRPYLLLIIVCLFAATIVGLTFSSSGLIFGYTIDNISPCNPVEDIRWAGRFFGGMWFLIACVELLANTTSWTGFGMVAEKLLYKIRVLCFRSLYEQDLDWHQSEGRTPTALLSVITTDAATVGGFSGSIIGTIFSIVVNFLVAIILSHILAWKIAIVCLVIVPILLGCGIMQLRSLSKFERRHAGAFSGAVGIANEAVNSFKTISSLSIEEEIISSYRRALRAPRKEITLASMYANLWLSLANSTGNLIYAFAYWWGSTRITAGEASQREFFIILICMLVSAQLWGQMFSLAPEVSRARAAASRILSLINLGSSQNDARKGKLTLAIEDTEKDVEACAEAPVKSHESKGATIVFRGVKFSYPARPHIQILTGMSFTISAGQFVGLVGPSGAGKSTIMSLVQRMHRPSSGTIEINGNDICAREGTEFRNDIAVVPQDCALFDGTIRFNVSLGSTPDHEPTDKEIHKACKLANIHNVIMELPNGYDTECGPNGSRLSGGQRQRLAIARALVRKPKLLLLDESTSALDAESERALQEGLARVARGITVIAITHRLHTVRKADVIFMIEGGKVVEKGRHEELVERSETYRTNALQQMLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK51</accession>
    <name>S0EK51_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_10308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436340.1">
        <property type="nucleotide sequence ID" value="XM_023569076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK51"/>
    <dbReference type="STRING" id="1279085.S0EK51"/>
    <dbReference type="GeneID" id="35403773"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10308"/>
    <dbReference type="HOGENOM" id="CLU_028200_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="40"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT74262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="380" mass="41899" checksum="159E5AD0FE494F1E" modified="2013-09-18" version="1">MSGNNSTPSLPPDVLNHNEGPSLIIVSAVSIPFALGVVAIRVWARHRKRMALERDDFMILLSLPLLWATAGVAIASVTYGGVGKPLAVNMMQDPNRLGRAQLCLVLTEFVYGTVLCTIKVGILLMYYRIFPTKSMRIGGYILGGMTFSWWIGIIFASIFQCSPVDKAWKPFMKDGTCLDKNKFFIGNSIPNIVMDAMIIALPVFEVSKVQVPRSQKIAIAGIFLLGGLIVIISCIRLKYIVALLQAGQEADFTKLISTPWIWTVIEPSVGLLCACLPTMQPLLYVLFGRFITKTTQDRSKEGIITIGGSGQKSADRQKGPVKDGPFRRLHDNDSAEEPVLWPETYHNQHSTVVEHSKGVAVDEIPLGTIAVKKDIRWEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK61</accession>
    <name>S0EK61_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to PUTATIVE TARTRATE TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_11418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437444.1">
        <property type="nucleotide sequence ID" value="XM_023570315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK61"/>
    <dbReference type="GeneID" id="35404880"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11418"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="453" mass="49728" checksum="90FB710E97402632" modified="2013-09-18" version="1">MTADLKNDSPPDLSDEAGTVDSSSQVNEKALLRKLDLKLLPAVGILYLLSFLDRSNVGNARIEGMIDDLHMSGNEYLTGLTLYFIGYVLFEIPCNIILKRTTPRLWLPTLTVAWGIVATLLGIVQNKTGFFIARFFLGVTESGLFPGVVYYFSMWYKRRERQYRISLFFSAASLAGAFGGILAYGIGKMAGVVWDNGWRWIFILEGIATVVVAVAAYWFIENYPDTSKFLTKSERSFIHERLHADSDAIREEKFSWAAPTIIKDLGYKAAVAQLLTIPPYAVAFITTLGVAIASEKLAKRAFFIAGSAGVAAIGYIILLANTNPTAKPGVSYVGTFFAAAGIYPATALVLSWPAINVSGQTKRAIANAMQISIGNLGAVMGTQLYRSGDGPRFVVGHSMALGYLVANIVVVTILGWRLKKQNDARAAVSEEIKHVGEVEDWRGDTDPRWRFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKW1</accession>
    <name>S0EKW1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable ABC1 transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_11292</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437323.1">
        <property type="nucleotide sequence ID" value="XM_023570173.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EKW1"/>
    <dbReference type="GeneID" id="35404754"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11292"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1239"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1277"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1308"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1435"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="140"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="833"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT75273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1467" mass="163691" checksum="FB8BA5702C96AA2D" modified="2013-09-18" version="1">MTPRHSTESPPDSIEMEHSTGSEGTYTRPSPLTRSNTMIMDEQDQQELQRIATGISQRRRQSFATVPSRVPTINEEDPSLDPANKAFDLSKWLPAFMHQLQEAGVGPKSAGVAFKNLSVYGTGAALQLQKTVADIIQAPLRIGEHLKSGKKEPKRILHQFDGLLRGGETLIVLGRPGSGCSTLLKTMTGELEGLHLGEESMITYNGISQKDMMKEFKGETGYNQEVDKHFPHLTVGQTLEFAAACRLPSDPKKLGLAETREEVVKDATQIVMAVCGLSHTYNTKVGNDFIRGVSGGERKRVSIAEMMLAQSPMAAWDNSTRGLDSATALKFAQAIRLASDYTGSANALAIYQASQAIYDLFDKAVVLYEGRQIYFGPASKAKAYFERMGWECPARQTAGDFLTSVTNPQERKARPGMENKVPRTAEEFELYWHNSPECKKLRDEIEVYQQDYPSDNRHEAIAPLRERKALVQDKHARPKSPYLISIATQIRLTTKRAYQRIWNDLSATATHVAIDVIMSLIIGSVYYGTGNGSASFYSKGAVLFMGILMNALAAISEINNLYSQRPIVEKHASYAFYHPAAEAISGIVADIPIKFISATVFNIILYFLAGLRREPGNFFLFFLITYISTFVMSAIFRTMAAVTKTVSQAMMLAGIMVLALVIYTGFMIRVPQMVDWFGWIRWINPIYYAFEILVANEFHGREFDCSQFIPSYSGLSGDTFICSVVGSVAGQRTVSGDAFIETNYRYSYSHVWRNFGILMAFLIGFMLIYFIATELNSKTASKAEVLVFQRGQVPAHLQEGVDRSVTNEQLAVPEKTNEGQDSTAGLEPQTDIFTWKDVVYDIEIKGEPRRLLDHVTGWVKPGTLTALMGVSGAGKTTLLDVLAQRTTMGVITGDMLVNGKPLDASFQRKTGYVQQQDLHLETSTVRESLRFSAMLRQPSTVSKEEKHEWVEKVIDMLNMRDFASAVVGVPGEGLNVEQRKLLTIGVELAAKPKLLLFLDEPTSGLDSQSSWAIVAFLRKLADAGQAILCTVHQPSAILFQEFDRLLFLARGGKTVYFGDIGQNSRTLLDYFEKEGARACGDDENPAEWMLEIVNNATSSQGEDWHTVWLRSQERLAVEDEVGRIASEMSSKNAQDDSASQSEFAMPFSAQLREVTTRVFQQYWRMPTYIMSKLVLGTIAGLFVGFSFYKPDNTFAGMQNVIFSVFMIITVFSTIVQQIQPHFITQRDLYEVRERPSKAYSWKAFIIANVIVEIPWQALTGILMYACFYYPVMGVQSSARQGLVLLFMVQLMLYASSFAQMTIAALPDALTASSIVTLLVLMSLTFNGVLQSPDALPGFWIFMYRVSPFTYWVAGVVSTELGGRLVECSRSEVSVFNPPSGQTCGDYMAAYLTQAPGQLQNPDATSDCQYCSLSNADQFMAGNRIYYTERWRNFGIVWAYIGFNIFIAVATYYMFRVKKWNFGKKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELU3</accession>
    <name>S0ELU3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_10944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436950.1">
        <property type="nucleotide sequence ID" value="XM_023569786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELU3"/>
    <dbReference type="STRING" id="1279085.S0ELU3"/>
    <dbReference type="GeneID" id="35404408"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10944"/>
    <dbReference type="HOGENOM" id="CLU_011640_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="703" mass="79490" checksum="6F7A4C59726257FA" modified="2013-09-18" version="1">MGRLTKFLSDAEKAVRQAGRDLQQQQQPAGYPQPQQGQQTQQYRNSPGYPTPYQPQQQQQQDYQTYPPPPVQPQAELQGSPIASPPPQPPQQQQQQYHQQQQYSYQAQQLSQGLPTSRSAPVPQHAEPSPSQAVSNSSPSTPMPLGIQPVTECIDMPFTLPTYWFIHSSYPDFVICSRCYADRILNSPFRDTFTPVWHDDRLERQCLFGTSRVRDYLWPAALSSMSLDNIMSFMATRPALGRCPEDKSVEGQEWYYPPDRPEMAICKPCYEDYFKHTSFGNRFSTHKPQGAASCDHNLWYIRRMLKLYSPNNNWTSFTTGFYKRLQLPPCPKAQPIAGPERTWFMSSRGPSNFSVCEACYWDYFHESTESQSFHTVRLGPSQQASCDMGQANMLIPMIRAVDKGNYPRFWNTLQGLSQHPPCNPQGASGIRWYTLPSDPPEFDVCATCMAGTIANMNTTHFFKVKQSVGPSEARLCSFNLPGYPRGVLFLQKFAEAAYINDWRPLSELAVDLSTAPACPKIDLELAKNRRWWGWDNAHICQECYVVVAKGTKLEKHFTMKGSQVAESRLCDLYSPRMRELYKNACKTQDLASFLSFARQRREIYLRTVPEMNRMLAAAKHALSQAQTLGLAAVTFSAAGNLNATNFYYDHTVGNSTVGHGYQNEQLLQAAMADHSMQQVGAAATGPAAVARVGVLERMWKQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELX1</accession>
    <name>S0ELX1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437623.1">
        <property type="nucleotide sequence ID" value="XM_023570521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELX1"/>
    <dbReference type="GeneID" id="35405065"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11604"/>
    <dbReference type="HOGENOM" id="CLU_1235077_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="256" mass="28381" checksum="72C9A4D9347183E1" modified="2013-09-18" version="1">MPESKSPNFLGPMGTDAGKSRRERNREAQQQFRKRRQAAEAARVQRLKRLEGVVERMSTVIVDFADKMLQEEILKQYPALAADVQNVITQVLSLANEAGDPEETKSSERHAQKSPGYGDDEWHTARSSQDSASPAGPQNSLIDMPLSFDQQDTKRSPPEHNQLRDTPQIVYPTIQNPPLDSHSPFSPPASMAHSLGSGIWNTPMSLSSTSVSSLPIQSRFDIGSRLSEQAALAHTFLGQTNLAYPDLYHDSMRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0ELY7</accession>
    <name>S0ELY7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable NADPH2 dehydrogenase chain OYE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437000.1">
        <property type="nucleotide sequence ID" value="XM_023569843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ELY7"/>
    <dbReference type="STRING" id="1279085.S0ELY7"/>
    <dbReference type="GeneID" id="35404460"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10996"/>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="402" mass="45196" checksum="932A81ABA9FA994C" modified="2013-09-18" version="1">MSTESKLWQPLKLGNATLSHRVALAPLTRFRNDDEHLPLDLMIKYYADRASTPGTLVISEATGISKTGEAAPNLPGITSPEQIEGWRMIYDAVHAKGSYMFQQIWDLGRAGDPDYLKKRGYKYSSSSAVQMEGKNGKPEALTEEEIWQKIGEFRQAARNVVDAGGDGVEIHGAHGYLIDQFISENINNRTDKWGGSVENRARFLLEVIKATVEEIGAERTALRLSPFATFQAAFTTNTWEQYGYIFNELKKAGYKLAYVSLVEPRGNPAYLDAAPKDLGSDKVNPFGDKKQSLEYFLEMWDNQSPVIVGGGYIPENVYDAVDGSYKKWDVIVAFGRWFISNPDLVFRLKYGVALTPYQRDTFYAPKTDQGYNDYTFSQRYLEATKAQTKYQELAAIEQAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM11</accession>
    <name>S0EM11_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable maltose permease (MalP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_11916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437917.1">
        <property type="nucleotide sequence ID" value="XM_023570869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM11"/>
    <dbReference type="GeneID" id="35405376"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11916"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF15">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT75871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="525" mass="58090" checksum="CAC8A0966AE6ECDB" modified="2013-09-18" version="1">MHQAKAHTETVEDTGEGLLMRSKLDDLSVWQSVRRFKRVGCIAMLAAFSASLDGYQINLNGGIVSNPGFIRQFSTSGTTIIAGKYISAWGGIQSAGQTIGQVLLQYATERLGRKAAMMIIWVVLTASVFAESFATHWQHWLVAKLFSGMGVGMLQSTMPLYLSEISPTQLRGFFINAYSFWFVLGQLFASVALKELKANDPLDFRTPIYTQWAMIGCILIAFLLIPESPWWLASKGRVEQASQVLNRCFANVEGYDVNQQIEIMTSTLAVERQQAEQNSELGPWAVFKGRNLIRFIISGWPKITQQFVGLAVFNTYATYFFQYAGNKDPFLVTLILSSVQLISMIATATLTDSIGRRPLTVYPYAVTVVSVLCLGIIGCFDYTAKATSSLLIFFACLATFSTTGASAIGYAFAAEIPQQRLRAQTAGWSLAVSNCIAIIFSFCTPLMINGSAKWGVKTGFFFAGTGTVAVVIAWFILPEVARRTPAEIDEMFEKKVNLRKFDKFVTEVQVNAHELQDRKKVVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM58</accession>
    <name>S0EM58_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438169.1">
        <property type="nucleotide sequence ID" value="XM_023571104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM58"/>
    <dbReference type="GeneID" id="35407699"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14247"/>
    <dbReference type="HOGENOM" id="CLU_1652289_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT76123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="160" mass="18117" checksum="E9424F7C525DBC25" modified="2013-09-18" version="1">MTVFCVPGYIRQSDEYLRTLNRFLTAGANFGAKMYLSSSNLRLSSLVQWWPNKGEESSVFDALLQGLQARAKMDGMQQANGRFMSEVVCTILVHEKTPRHYVSSLGDILPQVFSEHIAKPLLRMIGNTSDNCQGPSEKDKKRQCETIDILDCDKRRKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0EM72</accession>
    <name>S0EM72_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="6">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_11978</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="6"/>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437972.1">
        <property type="nucleotide sequence ID" value="XM_023570937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EM72"/>
    <dbReference type="STRING" id="1279085.S0EM72"/>
    <dbReference type="GeneID" id="35405438"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11978"/>
    <dbReference type="HOGENOM" id="CLU_024540_4_0_1"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000634">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="189"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="504" mass="56695" checksum="89E7F6775DAF7962" modified="2013-09-18" version="1">MLERQIAKIGMVGMGSVGSMMSLLFAEKGCKVYYFDISEYNMRAAEKMVKDVNKETRVFRQHSYQQLCEEIYSENHPRIIIFSIPHGNPGDECVKALRPYMSKGDIILDCSNEFYGNTERRQADLAKDGIFYVGCGVSGGYQSARAGPSMSPGGDPQALEIIMPLLRRVASKDRDGKPCTSPIGPGGSGHYVKMIHNGIEQGMMSVISEVWYILTKGLQLSYEEAAGVFEKWNETPELYNTFLIYIAVDINRTKDKEGRYVLGRIQDKVVQDVDNTEGTGTWSCEEAVRLHVPAANIVSAHMFRCASAELSQRAANAEASGRWQPSAMKVPSRSAFIEDLRKTTYFCLLLCFTQGLQIIREMDQQREWHINYQDLLHVWSAGSIIQAGGIMDLLHKVYSELPSKNNLLSNSQLGKQLTSLLPSMKRCTITALEADMVIPAMSQSLEYYKYSTSVDLPTQLTEVELDYFGNHRCDLKEEHRGEPSKGKHHFEWKPAKGESNKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENE1</accession>
    <name>S0ENE1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable GTPase Rho</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_09868</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436106.1">
        <property type="nucleotide sequence ID" value="XM_023568181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENE1"/>
    <dbReference type="SMR" id="S0ENE1"/>
    <dbReference type="STRING" id="1279085.S0ENE1"/>
    <dbReference type="GeneID" id="35403335"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09868"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT74028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="195" mass="22016" checksum="06B854442D17F522" modified="2013-09-18" version="1">MAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAVDSPDSLDNVQEKWISEVLHFCQGLPIILVGCKKDLRYDQKTIEELRKTSQKPVSPEEGEEVRKKIAAYKYLECSAKTNEGVREVFEHATRAALLSRSTRGSKHKKCLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENJ6</accession>
    <name>S0ENJ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBM-cenC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437665.1">
        <property type="nucleotide sequence ID" value="XM_023570572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENJ6"/>
    <dbReference type="GeneID" id="35405111"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11650"/>
    <dbReference type="HOGENOM" id="CLU_086416_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004486100" description="CBM-cenC domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="29376" checksum="9D55E05D4E89927F" modified="2013-09-18" version="1">MARQLVAFLAAAAAFSGVSAGPCKPASSIALSSTILVETTTAATSHDTASSTITADVTETTATDATTDATATTDALDTTIIGSTTDSATAGSITTFLTTTTEQSLEQSTTTTTAGPVGPGPCLEEQVLYNPSFDDNNNGWPWDLDSGVQVSSLSPRSPSYCLYNTPTSDNRVTTFSQALPALGDYEYELVYYLSLKSAQVNGLDFSCYANAFVNGKRMRDSGSFDQSSPSTYQRVGEVFTPQNSDDAGELRFEIQCDGEFEYADLAVDDVSLTRRCNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP44</accession>
    <name>S0EP44_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438165.1">
        <property type="nucleotide sequence ID" value="XM_023571100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP44"/>
    <dbReference type="STRING" id="1279085.S0EP44"/>
    <dbReference type="GeneID" id="35407702"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14250"/>
    <dbReference type="HOGENOM" id="CLU_052989_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496217" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="198"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT76119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="315" mass="34160" checksum="C6E0DC7F6C9AF54D" modified="2013-09-18" version="1">MHYAPASILPALLLAGTLSSCFPSQPKVREIVEIPGVRIENVASRSNGDLLLSTMGEGKLYSVNPYKSPPKLEMIAQIEGVNSLFGITEIGDDVFALAAGNDTGQQFQNNSMKLSLLKFNYGQLSVDTVFEESKYGPVNGIVALPYYKHIILGADSVRGEILRIDTTTGKITVAIQDKEFTPGVDGPYGLGVNGIKIYKNYLYFTNTDRRTFGRMKIDKLGKKVGDVEIIYRVEKGSPSIPDDFTIDRNGNVFVGIWQDKLIKITLDGEATVLSEGLLAGPTSVTLSRDGKSVFVVTAGMNNDNVSGGQVVQVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP70</accession>
    <name>S0EP70_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679034">
        <property type="protein sequence ID" value="CCT76184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023438230.1">
        <property type="nucleotide sequence ID" value="XM_023571175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP70"/>
    <dbReference type="GeneID" id="35407635"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14183"/>
    <dbReference type="HOGENOM" id="CLU_1825440_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT76184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="141" mass="15293" checksum="41B73FDD4F1B71FC" modified="2013-09-18" version="1">MTNLSDQDYDLEALHAEMQNAPNYLDPSCQLAAQIREAMVLIRCYELLQQSRAYQASEETIREDVSDVALDRGTDIDASQVSRPLSPPDPSELMGGKETGITADKETTVTGDTIVTEGERNATLGSSSESASTLEQPTIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPF9</accession>
    <name>S0EPF9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_11127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437126.1">
        <property type="nucleotide sequence ID" value="XM_023569991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EPF9"/>
    <dbReference type="STRING" id="1279085.S0EPF9"/>
    <dbReference type="GeneID" id="35404591"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11127"/>
    <dbReference type="HOGENOM" id="CLU_026314_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF5">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="3"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT75048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="622" mass="69202" checksum="9F839963A11D13EB" modified="2013-09-18" version="1">MDETQVIIVGGGPAGLALGLSLARLKIHSVILEKEAEITTDPRGVFLTGDAVRILHSLGINDLTGIGHEIPHLNFHLGAFNTPPFFSIRIGDINSLEQALPEGILQMQPRLEGALRKAIEESKFCSLRVACEVVSRSEQDPPVIDFNDSQGTRQQIKGEWLIGADGKLGIVRKHFLEPAVGIKQQDGLYPYSGTWIAANLKMKLPTPETHPEFPLWKFGYSPQEVYDLFWPVGWHFCTPPGKATASGRFGPYEERLWRHEFAQDETLIQDNSEELLWEHITPMITLEEDSSRSHKFGGPVHYPRDCIEILRCRPFHFVHKVVNRWFSGRTILIGDAAHVFPPFAGQGIGSGVRDAHQLAWRLALMLHPNSNPENQDKLLKCWESERRQSIDDAAQFSMINGRICNNEPSLLQRLCFRLLMFLHGTSVFRYMDYMSYKEKKGFSDVGNGFFVRERKGGSRLPQIHMRSKGLAESFLSDELLRKDNTIFTLVVVGDGNPVRQQGLHAEAKAAVQEAGLSSIISNDAIVVYDAQSGDLSPGQKRLSDTDGDLGHLTVCSPSETAAADGHMANRYDSSVFGKRLGRGTKFAIIRPDFFIFACSSNYAGLVSSLESLRGFVGFGGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EPX3</accession>
    <name>S0EPX3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437946.1">
        <property type="nucleotide sequence ID" value="XM_023570902.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0EPX3"/>
    <dbReference type="GeneID" id="35405406"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11946"/>
    <dbReference type="HOGENOM" id="CLU_001050_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046538">
        <property type="entry name" value="DUF6603"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20248">
        <property type="entry name" value="DUF6603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6603" evidence="2">
        <location>
            <begin position="947"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1627"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1639"/>
            <end position="1649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1716" mass="187468" checksum="DB47B251995AC366" modified="2013-09-18" version="1">MGSRIQDLISRQGIPRAGDPSKSLWKPVFATGGFIVDGKYKFYGSKAPDPGGDDAQVLDEGSNVDNFVNQLSGNCIILKTVPSGSDAIDIQLDASDGLATWMGHLDSQGLFNLTLKPNPEPAKGPWVIDAFSFQYKSPWDITFSSKEKALKFSFPPPAETFESAPGLDPNAPRIPAPGLEPDGKTLYLGLDPDRTKEDLHSTVKELFDFSESSRTPPALIADWKTTLVVQGVSAAGKRNGLWIRPSRSLQTSIRLQFSLDSTDVETFNKAITSTLKGFTFDSLDVICKKAVVLADTDDGNQPVAQGSVIFQAKCTIKPEGKSDVPVIAAINFYHGSYNITVQLNTKDAFGGILKWLMGLVPDLDLNFISEFLGDKDMFEQSGIYPRQIKIGLSCDDKGRNTKLKSFSFEIEVAAKFGTEKTGAGKPATPTFLVSYAWMADGPKWGSIKGELWNWYDDSVIRDMQPEYETTTDLYPLTDTPAKTLNLIKMIPGADIENVPSTVPTQISRAYVTLSRSGVRLGGTIESHAFESDNSPSVPQLDLGLLSIDAGFTWEGKKDFTLTIAFLARLQPAPTSVHKETALLKGGIDYSSGTGKWELKASLNSLYASSLYELFCKPTGASKDTSTADHVMPLIESIQVKSLDLAYHYESVKDGEDKGKSVGSAFELEGILLAAGLELDLKFHHFPSGSFTFIADLKSAEENASVSDVIKGILGDDSLELPGFLDNMAFGNEKDSAIHIEVLEKVLKDEPKETPDEKAFEVQAAGAKKKGSFQFIATLTLGNIKFSFVQLHQLDWESKVPSKRFFKASLTSVPTIEIPLVGNLTQPFEEMYFMWIQDNTNKNPKREPGLTRLDIKSLEDSMSLTTKDKFKEKDDSDLLMSAGSHFGVIIKDSEGKSVCILDYDFKKKADAPEKQSTFALMAVEEEESEEEKPPKADSDGGSASAPFKKKAGPLSINNMSLKYTDQILRIGFDATFELGPIGFSLLGFTINLKLTSLDLSKIEIPKFSLEGFAVAFEKPPLTIAGIVRHGNIPGLNYYAGGLIVGWVPYQLQAAGFYGEAKPQNRDSFVSVFVFARLDGPLVTLEFAEISGVTGGFGYNSEIRVPKVAEITEFPFIDQSQLSGTAGDALKTLEKLTDPRSEAGGWFTPRDDTYWAAAGMKIDAFQMISLDAVVVVMFGQSVKLGIYAVALVDIPNAKSPVKFAHVELGLGVTVDFGYGTMKVEGQLSPKSFILDPNCHLTGGFALYYWFDATHADKSLVGNFVFTLGGYHQAFRIPDGWPNPPRLGISWSLGSHLSLSGEAYFAITPKVCMGGGRLHAAFSAGPIEAWFDAFANFLINYKPFYFTSNAGICVGVRFNIDVLFIHTHISVEIGADLSMWGPPLAGRVHVDIKVAKFDINFGGNKGDNKAADIKEFYHLVLQASSQPAESRTAEEKPALVAEDEGDILPGDPNQGHTFLATSGLLNNSSSPDRKQNADWTVRGGSFSFVVGCKIAVQDVKQVDENNNVVNSVSSKGPPIYARPMHLREAMTKSEMKIEIVQDGVARAKWDMTQEYKQVPTGLWAKYDESQDPTKSSQGNNIDDLLDNNSGSLKLMMGVLMQGPPAIMSEDTLKAFNILAQGERVLKAKKPFPETELPEDAWDPSKPKDGAEQWKDVHNNWSSPEWSGNTDGGSEVQQTFVDSWFEIFGWGKALSGLGKLPKLLGERFDDLYVEAPLITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI69</accession>
    <name>S0DI69_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Related to FMP35 Found in Mitochondrial Proteome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423842.1">
        <property type="nucleotide sequence ID" value="XM_023575206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI69"/>
    <dbReference type="STRING" id="1279085.S0DI69"/>
    <dbReference type="GeneID" id="35395237"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01752"/>
    <dbReference type="HOGENOM" id="CLU_092488_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="215" mass="24455" checksum="CAA46EB06B0952F3" modified="2013-09-18" version="1">MSQQLALPRIIRRRLAAVLKSRTVTLRPAQRRWMTPAPKPGDGPMMSRRADRELPDVADVTFRWRRTFPIFLLIVAASSVAIFNYQKMSSPVVSSTLYALRTNQEARDLLGDEIYFKHQIPWIHGEMNQLHGRIDIWFSVRGTKGEGVMRFASNRPTSKGFFSTTEWSLTMSDGTRLDLLDNGDPFKALIGGGEDLPAVEDDAPTRGFRKQVEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DII3</accession>
    <name>S0DII3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">FFUJ_01559</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424022.1">
        <property type="nucleotide sequence ID" value="XM_023577362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DII3"/>
    <dbReference type="STRING" id="1279085.S0DII3"/>
    <dbReference type="GeneID" id="35395044"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01559"/>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCT61941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="366" mass="40947" checksum="BBE791BF9585602E" modified="2013-09-18" version="1">MSQDFAPLKNDLLLRAAWGQTVERPPMWVMRQAGRYLPEYHEAKGNRDFFECCRDPEVATEITLQPVRRFAGLIDAAIIFSDILVIPQAMGMTVEMVEKKGPHFPNPLQNPDDGQYGQVLAKNVDVAAELGYVYDAITLTRKKLEGQVPLIGFCGAPWTLFCYMVEGGGTKLFAQVKTWIYKYPEESKKLLAKIADICVDHLALQVKAGAQLVMVFDSWAGELGPSSYRQFSEPYLKQIAEKLPAKLQSLGLEKVPMTVFPKGAWYALDSACNLGYNVVGMDWLHDPKEAVKIRGDRNIVFQGNADPGVLYGTKEAITKAVEEMVEGFWVGNKGWIANLGHGITPGVNPDHLKHYFEEIHRLTKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ65</accession>
    <name>S0DJ65_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424372.1">
        <property type="nucleotide sequence ID" value="XM_023581706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJ65"/>
    <dbReference type="GeneID" id="35394656"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01171"/>
    <dbReference type="HOGENOM" id="CLU_909273_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT62291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="289" mass="33024" checksum="014E254A7CE9FCFD" modified="2013-09-18" version="1">MAENSLEVAGKARTVIFESISGRGPQGEPHLLGTDSEQRPFYSMSRCVLAETLIKDISKTVHRIFVYNDVDAADWNELPPIRRPMWSSGIQNLFFPHNSTDAYAWNHHHAVIGTGIPLRHQRSYTGVEVRMGSGGPIGEWHPEGIYHCRGMELYPDLKSYLRVPFGSATCIKLTFEVDYEDDNGMMMMISGVENVVPERPILPLDWHDSVRVDIAQEGHPHIISLNMRFVESQHPDPDVPHMTRVAVFSIKKIALLDTENTEINGRRVHNYHYLIKLRHYQGWDSDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJA8</accession>
    <name>S0DJA8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424412.1">
        <property type="nucleotide sequence ID" value="XM_023582183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJA8"/>
    <dbReference type="GeneID" id="35394613"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01128"/>
    <dbReference type="HOGENOM" id="CLU_1026903_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="271" mass="30785" checksum="5B363BE8534B0013" modified="2013-09-18" version="1">MCLDIYHDYQECGHHRYVRTYTCWQDRWEMFCPCLSFHGVIPYKNMHSSTENRQVRLGSCPNCEASKKKRERRDYGGFTAQQTHGAGASHGRGQLQTTQPTGGHQELRVPERAHQPGAYRQEPRMHMASQSRPSDRVYTSPPGVYIPHHSPAPSQGARQVGSSSRGIELTDMQPRRQYSDPHASSSKRERAVRGQQVGNKVIVDKGVPLPPQGQYKTPDTSRSRTVRNSPRRVGSVRDRVDRSHTVSPLTEDERNAPYVEIPSHDEYAGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKE5</accession>
    <name>S0DKE5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_01676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423913.1">
        <property type="nucleotide sequence ID" value="XM_023576062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKE5"/>
    <dbReference type="STRING" id="1279085.S0DKE5"/>
    <dbReference type="GeneID" id="35395161"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01676"/>
    <dbReference type="HOGENOM" id="CLU_053168_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004494925" evidence="2">
        <location>
            <begin position="20"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT61832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="341" mass="30711" checksum="673D8532B4B94D4D" modified="2013-09-18" version="1">MAVLNLVTLALALSSPAMARPRPQFGNGGDAQTPGAGLGGALPTALPSGGSGLIPSGLPSLGGGNGGAIPTPGSGFNLPGSGSGNDAPATTPGSGGGFFGGGSGGGIPGLGNLPFFGGGNGGGFFGGGGNTNTPPAAAPSGGLPGGNDGNTGGGASVPAPIQTPGTGGGVQGASFRGRGRSRNQDSPSIPGGSGNSQGGNGGGLGGSQPSGAIPTFSAGPGNGFGGSGNGGNGGNGDATEAPVAPTLVPTPGSGLEGPGTAPSGAIPTFVAGPGNGFGDGNSPSTPSTPIQTPGSGNQPGGGLGGSQPSGTIPTFVAGPGQGFGGGDGQNGGFQKRARSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKR5</accession>
    <name>S0DKR5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to nicotinamide mononucleotide permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425285.1">
        <property type="nucleotide sequence ID" value="XM_023573589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKR5"/>
    <dbReference type="GeneID" id="35393658"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00173"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF52">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="80"/>
            <end position="101"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="127"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="133"/>
            <end position="156"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="269"/>
            <end position="288"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="308"/>
            <end position="327"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="336"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="455"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT63204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="487" mass="54359" checksum="2FC1A27525BB1744" modified="2013-09-18" version="1">MSDKINEVGGPRISQDENPKSEQQAFDPVLEKKVIRKVDRNLVPILFLLFLCAFIDRINIGNARIQGLEADLNMSGEDYNIALFTFFILYILLEVPCNILLKNMRPSLFLSAIMTGWGIVTICQGLTQSFAGLIVCRVIIGGLEAGFFPACVYLLSMYYCRHELQWRFNLFFSASIVAGAFSGLLAYAIAHMDGIAGYGGWRWIFIIEGAATVVIAIWSYWMIPDWPETAKFLNDDERALLVDRLAADKKDTHMNTWDKKTAKRIFSDVKIYLGILMYMGIVTTSYSGSFFTPTILKQLGWTSIRAQIMSIPIFLFATVCALVAAIASDKTKHRSGFILGGCLFTTVGYVILLNMMSVSVGIRYMALFFIVAGGYIAQPIVLVWVSNNMAGHYKLGVASAMQVGFGNIGGIIASNIFVTTQAPTYPLGFGLGLGLVWLCGLSSLVFLLYIRRENKLRDEGKRDDRYNLPEDEKNNLGDDHPSFRFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL41</accession>
    <name>S0DL41_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425202.1">
        <property type="nucleotide sequence ID" value="XM_023573489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL41"/>
    <dbReference type="GeneID" id="35393747"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00262"/>
    <dbReference type="HOGENOM" id="CLU_082163_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT63121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="295" mass="35100" checksum="DB86B018EB383AA1" modified="2013-09-18" version="1">MDAQTSFLDLPREVRDMVYDYAFEDVNFSNAFTTQTAYSPNILPLLYVHKIISEDLQPRLYQNHAIVIPLQEPSTYAVGEWSIVPRIACSKIMKQRSNTLIIEMSQTTIPYYPDSDLEEDEDEDPVEEEVFWDSDSRGAKALPQKLISDILSLKQSLPALRTIKFVFWFGNWTAWSHTWEEHLEKLRATWPEPLLKIEMNLFEFVDDQVADGGFNWVEAWYYWAIERKRIWFQANNFKWRDHAKGDFRGRRINVRVWKDEEFLDWDEEEADRALHKKRCEVKPLFVRTCDMEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL92</accession>
    <name>S0DL92_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to tetracycline resistance protein (Probable transport protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425251.1">
        <property type="nucleotide sequence ID" value="XM_023573548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL92"/>
    <dbReference type="GeneID" id="35393693"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00208"/>
    <dbReference type="HOGENOM" id="CLU_001265_54_6_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF39">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="85"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT63170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="584" mass="62833" checksum="823B15A73C449115" modified="2013-09-18" version="1">MAPSRSTSSNAAARAMAVNRTASSGSFHAGAPIPTLSSLRRQSHRYQTFPTTPPKTPLEQPYAPSNGSDSEDEDDHEETPLPVRQLLLLAFLSLAEQTALNSISPYLPEMVLNMPGIPDDEAGLYVGILASSFALAQLSTNFLWGYASDVIGRKPVLIMGTTALMGCFCAFGFCKEYWQIVVVHVAMGLLNGNAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGRMGKEYPYLAPNILSAGLLALSVVVVSIWFEETLDKTEVNFEKPAWVEKIVSWFSSPTPPPRRASWSARWPRSQSYQNQPLLSSGRALESDDDDEETENDDESDNKADPAMSAWKDLSRTTILILFTYLVFQLSNISFNSLYPIFAATPPPAGRDLLPSKIGISLSIAGLASCIFQAFLFQALKVRLGNLGTYQISLLGLGISMLLMPWVGYADSKPLFGLGSGKMWLYIELGVVLILKNLCAVGGLSSVMLLITNSAPSHSSLGSLNGMAQTLSALGRSFGPFVSGGLFSLSINIQPKGEALAWSIFGGLAILGWVSSLFIRRDGLESDDWQGSDENLAEQDADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLJ3</accession>
    <name>S0DLJ3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424308.1">
        <property type="nucleotide sequence ID" value="XM_023580939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLJ3"/>
    <dbReference type="GeneID" id="35394724"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01239"/>
    <dbReference type="HOGENOM" id="CLU_2197042_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT62227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="108" mass="11950" checksum="4CF0BF81661EA306" modified="2013-09-18" version="1">MADQATITPAEWESLKKDETTAEVVADIMLRVIDTDPEEAGSYSEVREFRELTAEKLGVQWWIGDGELGADRGLSKIWMGLVEFLAGRQDVWEVGGIGAPPLTLTKKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLP1</accession>
    <name>APF6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">O-methyltransferase apf6</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Apicidin F synthesis protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">apf6</name>
        <name type="ORF">FFUJ_00008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="J. Nat. Prod." volume="76" first="2136" last="2140">
            <title>Structure elucidation and antimalarial activity of apicidin F: an apicidin-like compound produced by Fusarium fujikuroi.</title>
            <authorList>
                <person name="von Bargen K.W."/>
                <person name="Niehaus E.M."/>
                <person name="Bergander K."/>
                <person name="Brun R."/>
                <person name="Tudzynski B."/>
                <person name="Humpf H.U."/>
            </authorList>
            <dbReference type="PubMed" id="24195442"/>
            <dbReference type="DOI" id="10.1021/np4006053"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E103336" last="E103336">
            <title>Apicidin F: characterization and genetic manipulation of a new secondary metabolite gene cluster in the rice pathogen Fusarium fujikuroi.</title>
            <authorList>
                <person name="Niehaus E.M."/>
                <person name="Janevska S."/>
                <person name="von Bargen K.W."/>
                <person name="Sieber C.M."/>
                <person name="Harrer H."/>
                <person name="Humpf H.U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="25058475"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0103336"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">O-methyltransferase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF) (PubMed:25058475). The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L-phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L-2-aminooctanedioic acid (PubMed:25058475). L-Phenylalanine is the only proteinogenic amino acid directly used by apf1 (PubMed:24195442, PubMed:25058475). The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster (PubMed:25058475). Lysine is converted to delta-1-pyrroline-5-carboxylate (P5C) which is reduced to L-pipecolic acid (L-pip) by apf3 (PubMed:25058475). L-pip is epimerized to D-pip, probably by apf1 activity, prior to incorporation (PubMed:25058475). L-Tryptophan is N-oxidyzed by one of the cytochrome P450 monooxygenases (apf7 or apf8), and further methylated at the hydroxy group by the O-methyltransferase apf6 to yield N-methoxy-L-tryptophan (PubMed:25058475). The synthesis of the fourth apf1 substrate is more complex (PubMed:25058475). The fatty acid synthase apf5 is involved in the synthesis of the octanoic acid backbone of L-2-aminooctanedioic acid by fixing one acetyl-CoA unit and three malonyl-CoA units (PubMed:25058475). Then one of the cytochrome P450 monooxygenases (apf7 or apf8) may oxidize this backbone to 2-oxooctanoic acid (PubMed:25058475). The aminotransferase apf4 is predicted to catalyze the exchange of the keto group with an amino group (PubMed:25058475). The next step would be the oxidation of 2-aminooctanoic acid by one of the cytochrome P450 monooxygenases (apf7 or apf8). The last step is the oxidation of 2-amino-8-hydroxyoctanoic acid to 2-aminooctanedioic acid is catalyzed by the FAD-dependent monooxygenase apf9 (PubMed:25058475).</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is positively regulated by the apicidin F cluster-specific transcription factor apf2 that binds to the eight-base-pair motif 5'-TGACGTGA-3' called the 'Api-box' that is found in all promoters of the apicidin F cluster except in the promoter region of apf2 itself (PubMed:25058475).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to the loss of apicidin F production (PubMed:25058475).</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="3">Apicidin F, like the other known apicidins, is a cyclic tetrapeptides with anti-malarial properties via histone deacetylase inhibitory activity (PubMed:24195442).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLP1"/>
    <dbReference type="SMR" id="S0DLP1"/>
    <dbReference type="STRING" id="1279085.S0DLP1"/>
    <dbReference type="EnsemblFungi" id="CCT63356">
        <property type="protein sequence ID" value="CCT63356"/>
        <property type="gene ID" value="FFUJ_00008"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00008"/>
    <dbReference type="HOGENOM" id="CLU_005533_5_0_1"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-19329"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000437161" description="O-methyltransferase apf6">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="231"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="279"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O04385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="24195442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="25058475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="25058475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="25058475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="351" mass="39863" checksum="92F9574AE13E03F1" modified="2013-09-18" version="1">MASPSTDRLHLIEYLQDPGNPDGESRERLIEACQDVIASLERPIETARKQAFLTLDHAVIRSAIKLNLFKALDKEDRPYSTQELALATTPQCNHVLLSRLLRYLATRPLRLVIETSAGFWQRTARGSVFAQDSFKSGCSMYFDACGPAFQALPTWICTPDHERLHSPFQVAYPGQGSFFKRLQEDDSMLQTFQCWMETVSRHQFCAQETIDFNEWIPDGTSDSDVVFVDVGGGTGDQAIALGYKRIGLPGRIINQDLLPISQEAEEMLRSHNIERITYNFFDEQPLKGACVYHYRQIFHDWPDADCERILRRAKDSMTASSTLLIDEVVLPETGAHWMNDHKYNGVACYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM35</accession>
    <name>S0DM35_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425765.1">
        <property type="nucleotide sequence ID" value="XM_023571465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM35"/>
    <dbReference type="STRING" id="1279085.S0DM35"/>
    <dbReference type="GeneID" id="35398644"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05163"/>
    <dbReference type="HOGENOM" id="CLU_058132_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="60"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="271" mass="31002" checksum="B731BC8590E202B1" modified="2013-09-18" version="1">MKGGESSATSLSTALLCTGFIALVLAYWPNPLLPSHISSWWSGPQVREFPYQVQVFSTDPIILYIRDFLSPDEISHITKSVQDKFEVSRVWTDEVGYIDTSVRDSQSADLPSDHVSRRVKRRARTFMGWRNNKTHIQPLRAQKYNFNGFYNFHYDWIEHDPRYPGNRMTTIMVYLEADCEGGGTNFPKVTPPRDPRWCDVIACEGDVEYDDYPGTTFKPIVGSAIYWENFHPNGTGHTGTRHAGLPVRSGVKMGMNIWSWDLSWTPPTNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM48</accession>
    <name>S0DM48_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423689.1">
        <property type="nucleotide sequence ID" value="XM_023573528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM48"/>
    <dbReference type="STRING" id="1279085.S0DM48"/>
    <dbReference type="GeneID" id="35395386"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01903"/>
    <dbReference type="HOGENOM" id="CLU_031739_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="62490" checksum="45A5E547EAFFEBBE" modified="2013-09-18" version="1">MHLVARMDRDVLHGGNIWSPGPIFQTEVPFFWRKRRQLSIGDLPVEIFTAICRNLCVHCQHAHVVDLPPDEIDHAIEAQQALSRLSRTCRRFRNTAQPILYHCYHSGRQSNSSSSPEWWGDTDARRREVETLEGFLRTLLERPDLAKHVRALAFFALREVTARQISKETQALFRQAGERAGFRALPSYEHVDSKWLQEASIMAAPFVEQLLIYRSSQEGLQYIRDSPFYLPNLKYLVLPGQGKNPDECCHIQQMQDVLAKAQNLEVLAASDADCGTDIPLRERFRSEPWDTALASLRRLSLHGLDPDNLAKILRRSPVLEDLEYFCDMDKYTVLQHHHLAPVSQSLRRLCYTSTTWEHTSGGAQDIIEQVSMFLRWDSSLRGDASFVDFPRLEILEIEQLLLYGPVFDDEEERKQRFEAMKDIGPEIFMASLPSSLQILHIGMVLAWPEMHRDLLGMAKKVYRFQNLSVVAVDPYEAPPKEQIKELEDAFASKGIIFRIGQTTQVPFGRGMLGVRPGHPERSSEGDLKFPLNHRNPSYLDFLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMB2</accession>
    <name>S0DMB2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Related to DUF521 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_05073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425850.1">
        <property type="nucleotide sequence ID" value="XM_023571565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DMB2"/>
    <dbReference type="STRING" id="1279085.S0DMB2"/>
    <dbReference type="GeneID" id="35398554"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05073"/>
    <dbReference type="HOGENOM" id="CLU_018825_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01355">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01356">
        <property type="entry name" value="AcnX_swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012047">
        <property type="entry name" value="AcnX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007506">
        <property type="entry name" value="PMDh-L-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="PMDh-S-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36577">
        <property type="entry name" value="DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36577:SF3">
        <property type="entry name" value="DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="AcnX_swivel_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036630">
        <property type="entry name" value="UCP036630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphomevalonate dehydratase small subunit-like" evidence="3">
        <location>
            <begin position="30"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomevalonate dehydratase large subunit-like" evidence="4">
        <location>
            <begin position="171"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT63769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="596" mass="64092" checksum="778B53996BE56530" modified="2013-09-18" version="1">MGSLDEASWTGTAYVQGRATAKLLASNLELSFWGGVDPQTSEIIDRHHPLSGQHLQNTVLAIPGGRGSCTGSGVMLELLLNGKAPEAIIFERREDILTLGVMIAEEVFNQSIPVVVLDKEDFRHLIRLNGQTIFVDDGYVSTHPPSKHRKGSVIDTESGLILETTPALEGIKLSTLDQELLRGDYGEASRVAIRIVLRMAHLLGATRLMDVTQVHVDGCVYTGPATLALAERLRDWGGKVRIPTTLNSLSVDQKRWRALGVDTTFGEAADALGKAYTDMGARPTFTCAPYQLETAPKLGEQIAWAESNAVVYANSVLGARTMKYPDFLDISIALTGRAPKGGPHLGINRVASVCVKVVGLEDTTILDDSFPPLLGYYVGTLSTSRIPVITGLEKLGLSTDDLKALGAAFATISSAPMFHIVGITPEAPKLETVLAPEFTSVEVKLGDLGECWDKLNSAPANQPIDLVSLGNPHFSLAEMRKLANLCQGRRKAARVSVIVTCGRSVYKLAEQAGLIAQLEDFGVQILTDICWCMVTEPVIPTAAKTIMTNSGKYAHYGPGLTGRGMYFGSLAGCVEAACSGTYEAEKPEWLQSRRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DMH2</accession>
    <name>S0DMH2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to ECM29 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_05204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425726.1">
        <property type="nucleotide sequence ID" value="XM_023571417.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DMH2"/>
    <dbReference type="GeneID" id="35398685"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05204"/>
    <dbReference type="HOGENOM" id="CLU_000880_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="6">
        <location>
            <begin position="1281"/>
            <end position="1440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT63645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1829" mass="203056" checksum="0E888F61879456A4" modified="2013-09-18" version="1">MATATTKERELQLLDTVELKILNVANKEQKLHELLQRYLPPVILKAASEHAQVRARVVQIFSKLKTFIQSPEVILPVGALLDQYKSSDSPLVKQLDISAIQHSIERLDDYERRQLIPKALSGFAKDQGAARAGSFFNIILRLLLDARIPPRGSKDDTEYREAIGLSDEADAQFLSIMISTFLRLRNPTQTQNWTTANPTLTKSELESLAVESPESQKVFERMSELKLKLVSLLASGAFTDEEKFLPALYAASSFDNRLVSAAEEVLKRSSVSMENEALVKCLFHAHSILPPTYRTRILNMLCKSSISATMTDHIMAVVKLNFSTPDQALNGLEQSMLPKSALEQTKLHTATFQYLAWVASVGPSQEGFDIAVPLVNELADFVKRQGWPVPQQASHDDIALRSKAYETIGVLARSADMSIGSRIQLAEWLFKSLSEDTTSDAVVNIDGALSSLTTTIPAMTGSESQELKTMLLTFMSLADEPPAVRSTRHAVVKWANQCLTFSDVMARWLDVLAIGAYNDERSDVVEQGHRGLDPWTYHAHAETSLTLPDWKEMTATFFGSEIRPDTITETATGPLPNVTEKAHSVFENFQGSRIAAFPVALRYCKHMMFLTALPDFEVEPDWMQTLDARIKTDIKTREKILAYLHTVDSAYVIFYLKVCLDGAYMKDSPITEECIRCFVDVASLSPGGAMGFLIKFSDGLFQLIKSNNKEIRSLTARALGILVSHLANDPSVIDNCRKTLSALFENAERLVGPELNAAEGGLLAYSYVCSRSVYYGQSIPDEVHYPIQFITGEKVVSSLHDTALESFAQLWTAGLAIPEREGDHSLEKVISKLIASAKKGNEKAILALGRLAAGLSESGEAANESEDGWSHGILGSILKELFALHEIKQVEVQFTVGDAITATLARWESDYVKLTLDVESRGCIQKRNGSRGPLLKAVLNKIFADCKATKPSLLKASGIWLFCIVQYCSHLEEVQSRLRETQAAFMRLLSARDELVQETASRGLSLVYERGDADLKSALVKDLVSAFTGNSTQLKVDQETELFEPGALPTGEGSSITSYKDIVNLANEVGDQRLVYKFMSLAANAATWSTRSAFGRFGLSNILSESEVDPKLYPKLYRYRFDPNQNVQRSMDDIWKALVKDSGAVLGTHFDAILDDLLKSILGREWRMREASCAAISELIQGQPFNKYEKRYRDIWTSALKVLDDVKGSVREAAFKLCRTLSNTLVRQLEEGTSGSAAKSMMKEALPFLLSDKGIESSVKEVQAFAAITVIELTKKGGKALRPFIPEMVPQLLGLLSSIEPEQINWHYQRAGEDSRDQIDKIRSQMVNRSPISEAIDNSLRFVDADVMTELAPKLEATIKTAIGMPTKIGCSRVLTTLFTNHTNDIKGVSNKFLQLMEKQTMDKNDEVSQAYARATAYMLRAASDSVKSRFCKKFIDMYFEAEEEARRQKTADVIVALAKVSPDHFTALETQLLPFSYLGSHDTDEYTSKAFKKVWEQHAGSSRTVVRYVPEIVALVERCLDTAQWALRHGGAFTVAAMVSDVASASDVSGQISDANLNKTWPVFEKALALKTFAGKEKLLESYPKFVEKGHTLWKSDTKIAALMKKIALREAKRNNDEYRVHAFRCLWEFAKARDDIDMLDEIAEIVTPYLEELKGDDETENGDKMDIDSKDQVAKEQLAEKTASNGLEAIARGHSRTDLDILTKIINILKPFLSSPNFATIKRQVWYECVRDLMSDATPSSAPDENAVALTYLLSLDVDLVDTGTEAQRLMRAKAVGALFKAKGKGVFGPTGGPDAAQLKTMVSQALEAERSLEVQRVLRDILVEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNB6</accession>
    <name>S0DNB6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT63940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426021.1">
        <property type="nucleotide sequence ID" value="XM_023571772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNB6"/>
    <dbReference type="STRING" id="1279085.S0DNB6"/>
    <dbReference type="GeneID" id="35398369"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04888"/>
    <dbReference type="HOGENOM" id="CLU_022731_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT63940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="48232" checksum="190B1DAC815EE3FB" modified="2013-09-18" version="1">MNMDDPESAIESAPSHSELQPNDLQDQDRDRDQQQKAPSLNLIAENQIIQPDNDINNQNSSTTRQNYYTSAQWTADGTSLIVSSAINSISTFVLPEDLLDPSASRPRHLECQSSISLPEPSQTIIPAPFYSLAEPTSQTVLVGCRDHPVQLYHLFPPDDDGLASRSAPLASYKLIRFETEEYITPSSILWDAPGTHFLVGSTNRLDYFDMTRPGSDGPILTIPTIPSRRHIRKGNGVGMKGTVAALASSPVDGNGSSIIAAGTWTRWMGLYDVHRSDKVIANWSLPRSEDIPGGIGGQGIVQVRWSPCGRYMILNERHASGLIVYDVRGTGELLCTLRGRSAPTQQKMRVDVFSGDPYAEFPSFEVWAGTQDGGVAVWEGVGSQTGVVDPSWTWKPHDAPVGSTALHSSGSVVATCSGGWGFRNSSETKTVFDESSVKIWTIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNS6</accession>
    <name>S0DNS6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to benzodiazepine receptor, peripheral-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_01212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424334.1">
        <property type="nucleotide sequence ID" value="XM_023581250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNS6"/>
    <dbReference type="STRING" id="1279085.S0DNS6"/>
    <dbReference type="GeneID" id="35394697"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01212"/>
    <dbReference type="HOGENOM" id="CLU_091805_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT62253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="185" mass="20406" checksum="E0B7B7FEDF09C089" modified="2013-09-18" version="1">MTTYIPALTLPDAVFLKPALSVLLPIGLGTAVGFSATQTQKTYLALKKPSVQPPPWLFGPVWTVLYGLMGYAAYRVADIGLSPFSSPETIVNTRRAMTLYSIQLGLNLIWTPLFFGLYRPIEASVDIVTLLGVNGYLTYLYSSIDSVAAWSQVPYLGWLSFATYLCTTIGHLNNWDLKTKEAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNU6</accession>
    <name>S0DNU6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_04729</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426171.1">
        <property type="nucleotide sequence ID" value="XM_023571949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNU6"/>
    <dbReference type="STRING" id="1279085.S0DNU6"/>
    <dbReference type="GeneID" id="35398210"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04729"/>
    <dbReference type="HOGENOM" id="CLU_093932_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT64090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="122" mass="13367" checksum="168339E2475B604B" modified="2013-09-18" version="1">MAAIGTLVFCTDCGNLLPATKGTQRNVLHCECCGAENRDTGSKVTVTQTKPSDFPSFLRQKLQSSVQAVEKHNLQTDSTVHETCPKCGREEVKYTNVQLRGADEGSTVIYLCDCGNSWHENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP26</accession>
    <name>S0DP26_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to SRP40-suppressor of mutant AC40 of RNA polymerase I and III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426261.1">
        <property type="nucleotide sequence ID" value="XM_023572068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP26"/>
    <dbReference type="STRING" id="1279085.S0DP26"/>
    <dbReference type="GeneID" id="35398105"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04624"/>
    <dbReference type="HOGENOM" id="CLU_037040_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="370"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="439" mass="46265" checksum="32B2CF3BB989A638" modified="2013-09-18" version="1">MSGSKQSPPSWLFSNNPLNPINPSTDTMGKKSIEAAAPKNDAASTPPPGQLMDLVENFLSDHSFKGAADAFKKQREKKGWKATAATDEEGNPSLVSVYQTWEATKGDDSSKSSKSSKKKSSKKDSSSSASSDSSSDSSDAKEEDVDMKDAESSSDSDSDSSSDSDSDDEAAKPKASNTLKRKAPVDESSSDSSSDSDSDSSSSDSESDSDKPKAKKQKRAASSSSSSDSSSSSSDSSDSSDSSDSSDSDSSSDSDDESAKSDSGSSSSDSSSDSSSDSDSSDSDDEAAAKVPLPDSDSSSSDSDSSDSDSGEKEPKKDKKIKKEKEVKDSSDSSVTLDKTSPEFQSNSAYPPLPPDPVVNGNGRKKQNEPFSRIPKNIKVDAKFASNEYVSIAYSQKAHEDLIVTKGKGFTKEKNKKKRGSYRGGAIDIHDKKGIYFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP59</accession>
    <name>S0DP59_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase group protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424444.1">
        <property type="nucleotide sequence ID" value="XM_023567786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP59"/>
    <dbReference type="STRING" id="1279085.S0DP59"/>
    <dbReference type="GeneID" id="35394577"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01092"/>
    <dbReference type="HOGENOM" id="CLU_012587_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="74848" checksum="18AE7948E6653B9E" modified="2013-09-18" version="1">MPIEILETIANINYNTPRPCPIDPAVLYDLLKIRRLVDEATNLAVRAASDIASPVLTNVHGGLPGASPMSVLGMTGPGHGTKLSRERKFRMREQASQKLSRAYHLDEIACSVATMQGASPIDEIGALVLFRNPQDPDAKYVHFFHEKIPSRQLAESTSLQPLADIISERPNEGEALRTRAIVKTFKEDFEGAAHDLTAALTVCRIHQQPHRPSGDELDSQYSHRGRRWRQDIIPSEKEQPSSLETQLLFLRGAAYLSVACQHIEDGIPTSQSQSGHADSHSPDEAFDPEVSGRKPPEIEEKPLREQTEAQKLVKKYAKLAIRDLLAFMSHLEYAPNLPSSIAKDFNDRVNSSAKGTRHPRPSEATYSLEPHTTYAISELFAAVPPSDLPPYPSQELTKSNGKTPLFDMPQTCEWSTYHPLMADALHSLLLCHCLAQTSTKELERHTYMAARLIRIADGYPVFQPSRSAARSDWVEILRRADDNWLQLSASWETLCIPVPLPFLYDTLPQNISKMHIGTTRKEAAAAAASLINGGPDNARPAVPSAADKDRQLKREHNQRVYEALSDERVCDDATFRASLMAREKRDERERAAATAAANGSSSNAISTNNSGPKGWSDEDSNDYPLCSVRASLIAQWVQKVPPVTGTTRRKKRTKKPVSRAASLAGPPEKRNLEDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP72</accession>
    <name>S0DP72_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_04415</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426450.1">
        <property type="nucleotide sequence ID" value="XM_023572302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP72"/>
    <dbReference type="STRING" id="1279085.S0DP72"/>
    <dbReference type="GeneID" id="35397896"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04415"/>
    <dbReference type="HOGENOM" id="CLU_039622_1_0_1"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="118"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT64369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="294" mass="31633" checksum="E26DEEBCF566E7CA" modified="2013-09-18" version="1">MAHPQGNLANLLPPSWKTSVTAWLAEDTPSFDYAGFVVGDGPRVATLWGKSSGIIAGRPFFDEVFTQCGCTVEWHAEEGTAVDLSNGKHRVATVKGPVRGILLGERVALNTLARCSGVATKSQRLVSIAREAGYTGVIAGTRKTTPGFRLVEKYGMLVGGADAHRMDLSAMIMLKDNHVWSRGSITDAVKAAKSVGGFSMKVEVEVQSEAEADEAIEAGADVVMLDNFTGDGVKVASRSLKERWQGKRHFLLETSGGLQEDNFEAYLCNDVDILSTSSIHQGVPHIDFSLKIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPA5</accession>
    <name>S0DPA5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to purine utilization positive regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_00142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425313.1">
        <property type="nucleotide sequence ID" value="XM_023573623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPA5"/>
    <dbReference type="STRING" id="1279085.S0DPA5"/>
    <dbReference type="GeneID" id="35393627"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00142"/>
    <dbReference type="HOGENOM" id="CLU_013897_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF14">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="309"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT63232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="684" mass="77005" checksum="41AA0307585A0572" modified="2013-09-18" version="1">MDTRHLDLAIVLVHQEEKDIATLNNNVPCFQLSNHLFQKHAVGVGHCDLRVPQCTACARQNEACNITDCVSYPYTVVRALQDRINDLEARLRLVPTPNEIVPEPEPEPSEVNPEPRADLQKEAEEVGFLTTGGSDLYSGSKYVGSAAGSTFARIFFKQLNLVPSWDSGSQGSGLEQPLCEATAALPPQPIARALLHIYISRVHIWWPFLQLPHLRRVFQRIYESPRQCSDHEKFTVFVTLALASSQLTTKDAQSPAMMDLNDSNAYFQTSLRFFNNFSDHPRDLFGIQAVLLLAIWMLDSSHSSHNNDLWQLSRYIMSAAIEAGLHRHNKDWGFTAEELEVRNRTWWCAYNLERQVATLTGRVLSIRDHAVHTMLPNPATFDALTPLESSMAPVLHKHNVEVIRHIITLRRIGGRILESIYIARGPSGTAMDTTFQQICATSDQIRRDLELWEQQLEAMGLKPSREYSEMKIEYCLLQLLLHRPSPTFMVPSRQMASYCSKAASTAISHWSKIEGEYGISAICRCFRQLHDIILVGLAALYYDWQAMALPQTGDVAPRSHRHFNDTAICLDLIDRGITNMRAPYLTKYKDLFQAVRNKVYAKTIFTSISPGATNSTISPGTMSQGLIFNPSDDMMFSMGDGVEAYVNQVNEFLDGGGFNVDEALDAWYDALMGEIQNGDAQMME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPD6</accession>
    <name>S0DPD6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of phospholipase D SRF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426382.1">
        <property type="nucleotide sequence ID" value="XM_023572218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPD6"/>
    <dbReference type="GeneID" id="35397971"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04490"/>
    <dbReference type="HOGENOM" id="CLU_027163_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41863" checksum="DDF7974387140A1B" modified="2013-09-18" version="1">MTSPSPPRTGTGTGTYHDSPRTYDSGRTLSSSVAGRSARLRPPRSLPPWIDSWDDKHGSVSDDQLRLLQPPTRAVPPQHNSSPSDPQRRISKDGFVDPQDPLVGQGQETRGKIPHFMRYGRASMRGRKWDHLRSAEPVIVPGHKPALTSQPNIAWQDFVQSSAWGRMTNEDSKVVDVEALNDLQPNFNTPARHPYDAQEARVSRKKRTLAPYKRLWNIAIRHSLAPLMFRLSVMVTSIIALAIAARIHLLEDVDSTDSAEETQSIVAVAVDCVAIPYIGYMIWDEYTGKPLGLRSVVSKISLILLDLFFIIFKSASTALAFESLVYHNLSDTAVRSLSKALAAFMLMGLIAWTMNFAVNIFRTVERLGGGEDDGLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPH3</accession>
    <name>S0DPH3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to 1-aminocyclopropane-1-carboxylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426540.1">
        <property type="nucleotide sequence ID" value="XM_023572412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPH3"/>
    <dbReference type="STRING" id="1279085.S0DPH3"/>
    <dbReference type="GeneID" id="35397798"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04317"/>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="89"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT64459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="429" mass="47791" checksum="4F0D2EE87BF1F7AD" modified="2013-09-18" version="1">MLINLDFSDAKMGFLSQRATEAVGGLDLPWRFAPRGDYDADHNPDGLISFGTAEHALVTKDLKEFTDKNVTISYEDFLYRGSHAGGSRFPKALAAHLNEYLQPYSPVAPDMIRCVGAATAMHDILAWGVADPGDGVLTSRPVYGRFELDFGNMSQVRVVYSNNKIEEAFQDDIVERFAEALLRSRKAGVNVKMVLIVNPHNPLGRCYHKSTLISIMQFCQKHRLHLLSDEIYACSVFDTDEPAVPFTSILSINPTGLIDPELLHVTYGLSKDFGAAGLRLGAIITRSQPVLRAIEAALRFNNPSGASLAIGSAMLEDRTWCRAFIDSSRLKLAQAHRHITSLLRDMGIKYLPGSNAGFFIWVDLSPYLPSDLDGESNQEFALAKRLHKMGVFLHPREEHSIEPGWFRMVYSQDPRTITEGLRRIHKAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPK3</accession>
    <name>S0DPK3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_04414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426451.1">
        <property type="nucleotide sequence ID" value="XM_023572303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPK3"/>
    <dbReference type="STRING" id="1279085.S0DPK3"/>
    <dbReference type="GeneID" id="35397895"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04414"/>
    <dbReference type="HOGENOM" id="CLU_035730_5_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495010" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="168"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT64370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="336" mass="36248" checksum="DDF3C93E1CC7D280" modified="2013-09-18" version="1">MKASMFLLGASAILASASPIRNALEKREIEKREMKTEWVYEVVTVTVVAGEEPETAAPVATKPTGVVFMEAPAPKYTAPSATKEAAKPKKVKKPVSKPSTTEEAPKVTVVTVEPQPESTKETVYESPAPVVEKPKTTISKVVAKPTKVAEPKVEVPASGGDDLSLDGAYNTVMLAYHNIHRLNHSASALEWDDELAGYAENTANGCVFEHDMKQGNGGYGQNLASWGATSDIDGLKNKAAAGGITNQWYNNEMANWAFYGQENPPADMNIDLYGHFTQVVWKDSTKVGCATVKCPAGTVLSFPSWYTVCNYNPQGNFGGRYGDNVLKPKGEKRVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPK5</accession>
    <name>S0DPK5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424574.1">
        <property type="nucleotide sequence ID" value="XM_023569341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPK5"/>
    <dbReference type="STRING" id="1279085.S0DPK5"/>
    <dbReference type="GeneID" id="35394437"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00952"/>
    <dbReference type="HOGENOM" id="CLU_029404_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="382" mass="42007" checksum="AD560D39510FDF2B" modified="2013-09-18" version="1">MPSQPSSILAAVPTFFLPSLPVRRPICTAWRPCRKRRFASTTTRLLHDAPILPFRFETGIGLFAKRPPRPFPPPFLSPPSTSFTDPLSTHHQSRDRRAFVNGQLIRGKTNGDDAVYASDYFICANDGVGAWATRPRGHAGLWSRLIGHFWSSAIEEELVGLPKSQEPNPIASLQSAYEQTLEATMSHDCLGTTTACGAQLHYKTCTENEAQASPVLYVTNVGDCQVMVLRPSTEKVIYKTVEQWHWFDCPRQLGTNSPDTPTDNAVMDRVDLEVGDIVLAMSDGVIDNLWEHEIVARILKSIKEWESGTHAEAHKGDRTGGRNGGMRIAAQDLMEAAREIAVDPFAESPFMEHAIEEGLASEGGKLDDISVVAALCVKNEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPU3</accession>
    <name>S0DPU3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_04209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426640.1">
        <property type="nucleotide sequence ID" value="XM_023572534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DPU3"/>
    <dbReference type="STRING" id="1279085.S0DPU3"/>
    <dbReference type="GeneID" id="35397690"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04209"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT64559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="468" mass="53156" checksum="CA8A5FA09DF8A767" modified="2013-09-18" version="1">MGKNGNLWYWTVGDETNMAICRVPNMFATGNSKPHSLRKRMISNVYSKSYIQSSQASKLQMAEILVNRLLPALDGSLKPSRKSMSTDYNDVEVFGLYLATAMDLITAYIFGLSNATNFIADEPYRRDWQDMYLARANYPFWTQEVPKLTNFCKRWIPWLKLYPQWVDQSNKKLSDWNWELCENVRKTPKATRSLSNSQDIQRSDEPVVYSSLLAGIDREFNTNGEKSILYSTSILQRDRAIASEVMDHSLAGQETAGIALTYATWRISKTPELQRQLHAEVQSLKPALRINPKAASGLTNTSALPDPKEVDSLPLLHAIVTETLRLHAPIPGPQPRQTPQRGCSIGGYYIPGDVRIASLAYTLHRDKEVFPEPEEWIPKRWIPQAPGKSSDDEAKHREMQRLFWAFGSGGRMCVGSNFAMNEIKFILAFIYANFETTIVDDEGIEQEDAYTARPIGEKLVIRFTPLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DS90</accession>
    <name>S0DS90_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable PPA1-H+-ATPase 23 KD subunit, vacuolar</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_04540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426338.1">
        <property type="nucleotide sequence ID" value="XM_023572161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DS90"/>
    <dbReference type="STRING" id="1279085.S0DS90"/>
    <dbReference type="GeneID" id="35398021"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04540"/>
    <dbReference type="HOGENOM" id="CLU_085752_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="111"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT64257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="181" mass="18679" checksum="A0882C8E9F30B9AF" modified="2013-09-18" version="1">MLFTGSGESFDIGGFLESVSPYTWATLGIALCIGLSVVGAAWGIFITGSSILGGGVKAPRIRTKNLISIIFCEVVAIYGVIMAIVFSQKVENVSGAELYSANSYYTGYALFWSGITVGMCNLVCGVAVGINGSGAALADAADPSLFVKILVIEIFSSVLGLFGLIIGLLVSSKAPAFGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0DSY7</accession>
    <name>S0DSY7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427617.1">
        <property type="nucleotide sequence ID" value="XM_023574220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DSY7"/>
    <dbReference type="GeneID" id="35395967"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02485"/>
    <dbReference type="HOGENOM" id="CLU_1129087_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485248" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="154"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="230" mass="24214" checksum="3F593733CAFF502B" modified="2013-09-18" version="1">MPSVNTFITALVAGFAIGAHAGPCRPHASSSVIQYPVSTTQQTAAGTSAAYTYVVSKSDAKTSLSTTAVQVTSSTKDESEPAAKTTPTAKEDATSAPYTSTSVPETTSKPKTTLETTTVAPTTTSKPTTTTSEAYTTTSAAATSSCPPSSELTCAKTGFFSNADSNLIQVYYDYNLSQCQEECEKTDNCKTIGITTSNQCELYDAAVSALGFEFRDGWYYSVYDACCFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTH1</accession>
    <name>S0DTH1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to PET127</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_02854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427955.1">
        <property type="nucleotide sequence ID" value="XM_023574634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTH1"/>
    <dbReference type="STRING" id="1279085.S0DTH1"/>
    <dbReference type="GeneID" id="35396336"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02854"/>
    <dbReference type="HOGENOM" id="CLU_003477_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="629"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="724"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="945"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="870"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT65874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1061" mass="119782" checksum="42E79AF31BE762BB" modified="2013-09-18" version="1">MLRLRRGIPPAATFAHICRPHLRCPRQCSPLRLFATETRPDDTSIPTPKPAPDSEDVLNSTKTASEKTGKGAKVAERKKEGKKRRAARLEVKGSTEGTTENDISDALAVAKRVYGIDKSKKKKKTKGSKPRSPNEQQRTDKADSSEATSGVVDQQTGAWASLKEKLQQVLATEPSKDQTAPQEDHTTPSPELDQHTIANSHETELSAAAPPLKKKSKTVKRQKKALPPVYTIKPQYLKLKAVEEESRRSVPKLAHQLDKVLFNGGPYQLQDQRTRVYNFDPYLASIMPVDEFDFDALKEYVTSSKDSRLTDLCAKYKKKYCGSTSSMTAMLSQFHFLLSAWRPLSFRHLSRSFEVEYDTFTVLTRGPAAAFARYKDGVYAIDADKEFDTANVLSMLGKSMEKLLTLKKPHFEKYRRSRSHELSEEEKNADEAFHFSTLGDFMMRSQLDAHDPRLPGTGMFDLKTRAVVSIRMDVGGYQKGVGYEIRSRFGTWESFEREYYDMIRAAFLKYSLQVRMGRMDGIFVAFHNTQRIFGFQYISLEEMDEALHGTANRSVGDEEFKVSVKLLNDLLDRATKRFPKKSLRLHIETRPTNPPLTYFFAEPVSDEEIQKTQEKGSEAVAMFKNNMLRIPQDEENSRMNDEAEPQTKKDTQKLSSTERQKSWDEMMAKVDQTVEDDAAGLDSVREAIEQALEQSGLLTGKPELERETYINELVEALAEELKDNKEAASELEDTAQMGLAEDDALNTSESSSETEDALLPSIEASEGDNSNNDVYSKDVEYAGKETEPGLTEDVETRAEDEGHSSILSDAVDGTDISLNSDDSADATLKDLIIKFAQGVDNNQSNLGTFERVLSELVRDQKEPASEVDESNTATIDVSPTESVKTSGADKPSLTEEERSDEESDSIPKKDILGLYVTVRNMVDGEVVERISCADQEEPINWKVEYTVVELQADRARKILKELKKRRKKALVSTPEDREREWHRMWGGTLPERTEAGRKYRDSVMQREEQTGVKLAWEADARNKTNMNKRKEAHSRKGSEKRGRSKEKTKTKKGEKTSPIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DTH3</accession>
    <name>S0DTH3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to UTR1 (Associated with ferric reductase activity)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_02689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427801.1">
        <property type="nucleotide sequence ID" value="XM_023574452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DTH3"/>
    <dbReference type="STRING" id="1279085.S0DTH3"/>
    <dbReference type="GeneID" id="35396171"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02689"/>
    <dbReference type="HOGENOM" id="CLU_008831_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000029">
        <property type="entry name" value="NAD+ kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT65720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="605" mass="68467" checksum="3B85412160F0C383" modified="2013-09-18" version="1">MGDHTEKHIHFEDGRNREYDGSSDEDCKAVEVVFDPGNPYRRKSSMVASEIKAPVMRHPSRRDECLVHQFLDSQRRAKDAASSASEPESEPSIGNNSPSYLSNNPNPSHATFHKALNGDHIEAVRDDSLNSIVDPKYQKKCRAVVEPGGMEHSGQADQQAWTQQMTKSMSDVDLSGYQDDVRSRLLTKQQLSDMAWGVRELSRRLSSMRLRFKVKSIFILTKIYDQDLIPKTRELVKWLLQHSHEVAYTVYVQDKLKTNKKFDVSGIIDEVSKGYLDRGDMNEQAVKETLNRRLRYWDENMCRTRPHTFDFVISLGGDGTVLYASWLFQRIVPPVLSFALGSLGFLTKFDFEDYQQTLLTAFTKGVTVSLRLRFEGTVMRSQPRKRAQLSQGPEEDEEQSRDLVEELIGEEREDEHTHRPDGTFEILNEVVVDRGPNPSENPRVNVTPAGDILMYIPAMSTTEIFGDDEHFTSVLADGICVSTPTGSTAYNLAAGGSLCHPENPVMLVTSICAHTLTFRPIILPDTIVLRVGVPYSARTASWASFDGRERVELKPGDYVTISASRFPFASVQAEGRRSEDWVNSISGKLGWNTRQKQKSYKEWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DU41</accession>
    <name>S0DU41_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_02969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
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        <property type="protein sequence ID" value="CCT65976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023574762.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1279085.S0DU41"/>
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    </dbReference>
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        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin cofactor biosynthesis C (MoaC)" evidence="6">
        <location>
            <begin position="56"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT65976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="199" mass="21440" checksum="BAE621AF10D9D437" modified="2013-09-18" version="1">MPPRMQYLLYNGPCFKAGRSVFTQQRLFSKTRHVRGQDSSDNATLTHVSASGEARMVSISDKTVTSRIAKAACTVRFSNSTAIGLIRDNQMKKGDVLGVARIAGIMASKRTPDLIPLCHPISLSKATVDLDVRGDDRVEIAATVTCDGKTGVEMEALTAASTAALTVYDMCKAVDKGMVIEGLRVVLKDGGKSGRWEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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    <name>S0DU57_GIBF5</name>
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            <fullName evidence="3">Related to brefeldin A resistance protein BFR1 (Maintenance of normal ploidy)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_04751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
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        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023571925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DU57"/>
    <dbReference type="STRING" id="1279085.S0DU57"/>
    <dbReference type="GeneID" id="35398232"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04751"/>
    <dbReference type="HOGENOM" id="CLU_023943_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
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        <location>
            <begin position="173"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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            <begin position="13"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT64068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="474" mass="53498" checksum="6468E88E992408BD" modified="2013-09-18" version="1">MAETATSPAPAADKADKQANVRPAKPDENLFKQELAKAEKEHKASMDRLAAVKAKIEIAMPNKNKDQPNPTQKRRQELIAQANEIRQKQAGGKNARSTKLDQIKRLDEQVRSRINEQKAAKNKVPFKSLEDLDRQIASLDKQVNSGTMKLVDEKKALSDISSLRKMRKNFGQLDDSQKQIDDLRAKIKEIKDSMDDPEQKALSDQYNKIQAEIDAIKAEQDEAYKGLSSLRDERSKLQAEQQEKYTAIRKLKDDYYGQKKAYQAYDREARERYREKQRAEQERYHQERKKAEAERRLGDASDPAYLDEIRRANSLLQFLDPNHKVEKGPLMADTGLGAQAQRSVDESGLKGTKLLRKEDRDEEYAPAVKKGKKGKKTAHGGSSNKFNVPPAVVEDCAAMGIDPPMSAADIPAVAEKVRAKLDFWKNDQEAQTQRNIEKAKKEIAELEAAEANGDKVEQTTADLKETSIADKQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DUA0</accession>
    <name>S0DUA0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein ECM13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
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        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023574975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DUA0"/>
    <dbReference type="STRING" id="1279085.S0DUA0"/>
    <dbReference type="GeneID" id="35396641"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03159"/>
    <dbReference type="HOGENOM" id="CLU_058482_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28432" checksum="BFEA370E81972D98" modified="2013-09-18" version="1">MSTTTTTTTSIHRPTASKTSSLQQSTLKKNMSITQTYYLAHKARAKLSREAAQPDHDLRLLVGHANLLDSLMLELADAEREQERWFNQSVRGATNAQQERRVQWADNIVEEEDEDDYDSDSSDSDDYDSEDDDIEMANTSLPAKPMSPRITHIELDEDMEDDDLEEDYAQLELVRTPSHSNSPPELVDHDSDSSDDDSMPPSPPQSILTFDEKDVKEQSQQEQESNSLYDEEYYLPPRNPARLVSAISVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVE2</accession>
    <name>S0DVE2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_02316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427458.1">
        <property type="nucleotide sequence ID" value="XM_023574032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVE2"/>
    <dbReference type="STRING" id="1279085.S0DVE2"/>
    <dbReference type="GeneID" id="35395798"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02316"/>
    <dbReference type="HOGENOM" id="CLU_070374_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495252" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT65377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27220" checksum="9040668C3F9D81EC" modified="2013-09-18" version="1">MSFLVKLGLIFSIFTTWASCFSKFLRPPERDPDQAVDQDMTKNNHYEDGEMIPILYNTNIKKVDLYIWQFIDAEKNTTARLENDGTSDSTGWKAQYDISNATENNEDCIYWFSLMDSKYGGLLAKSQYVNVSAPKAEETTTDSSASRDTSSAFEPSSKSGLSGSEIAGVAVGATVGGLLILGAMGWMVWRRRARRKDDAVLAELPGNYEQDQPHSERPKSELPAEPVVFSPERPRSPPRIYEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVL4</accession>
    <name>S0DVL4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_03630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428670.1">
        <property type="nucleotide sequence ID" value="XM_023575499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVL4"/>
    <dbReference type="GeneID" id="35397112"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03630"/>
    <dbReference type="HOGENOM" id="CLU_976746_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="285" mass="31379" checksum="684DE6095E9136F5" modified="2013-09-18" version="1">MSRIEDSKESLRNSTIPNATGSSEVYGVNLTPSKWAAYGKRKAEGWYARNGTYTLAQLDSEIARLESLLRSYELASSLVDKDKDGKPQYPVAGALRPSQSLEDSKAKVEAAMTSLYEKQAASAGVIYNLQQGKPGDQEKAQKEVLDAQKKLQAAQDQSKTNQQAWNEYTQIALTETTKKDALNWFDKKETTIKQELDRLKSLRVTKVEDDTNKATSVPVIVSTTAPADKNEEPTGTTLAARGSEMANPVFKSPSDQPLTAQDADPWTNIIFSYFASDVSNHSKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVT2</accession>
    <name>S0DVT2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable SPB1-required for ribosome synthesis, putative methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_02460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT65512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023427593.1">
        <property type="nucleotide sequence ID" value="XM_023574192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVT2"/>
    <dbReference type="STRING" id="1279085.S0DVT2"/>
    <dbReference type="GeneID" id="35395942"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_02460"/>
    <dbReference type="HOGENOM" id="CLU_009422_8_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="229"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="620"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="426"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="492"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="589"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="737"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="494"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT65512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="830" mass="93617" checksum="1EF044AB81CBBEFA" modified="2013-09-18" version="1">MARGVSTNGKLTQTMNPGYRARAAFKLIQLNKKYGFLEQSKVVIDLCAAPGSWLQVCAEFMPRQSLIIGCDLTPIKPIPGVLSFTSDIKSPECRATLRQHLKTWKADTVIHDGAPNVGTAWVQDSFNQVELALHSLKLATEFLKPNGVFVSKVFRSKEYNSFLWVLNQLFTKVDATSPPASRQVSAEIFVVCRGYKSPKKLDPRLLDPKYVFAELQDPTPNNEAKVYNPEVKKRKRDGYEEGDFTQFKEMAASEFIQTTDPIAVLGSYNRLSFKQPPNGDVALAALDKLPETTDEIRNCCSDLRVLGRKDFKILLKWRLKMRDIFQLKTPQAAIVEEPEEVAEVESMDEELKIQEELQNMKDRENTKRKREKRKENERKQREVVRMQLNMTTPFDIGLEESGPIGEGAMFSLKKVDKTDAMRRLNRGKMIVPTQATQKEADSGLGSSGETDDESDPEEDRLERELESMYDQYKERKAEVDAKYRAKKARKNFGDDEWDGLSGEEADEKDDSSELEEDDSSSDEEDEAPTGGLIRDLDSSKGANGLSKRATAFFNQDIFSGISGILPEQEDAAVDSADEEVNRDAAAIVAQQAKNRKAEAPTKPTKTKTAPADSDSEMGDNENGFEVVKRNQDDDWDKDTRRADGRPDIDIITAEAMSLAHQLATGQKSTYDAIDDGYNKYAFRDRDGLPDWFVEDESRHDKLQKPISKAAAQAIKEKLRAFNARPIKKVREAKARKKFKAAQKLEKLKKKSELLNNDENMTEKEKADSISRLISKAAKKPKKQAPKVVVARGLNRGIKGRPAGTKGRYRIVDPRQKKELRAQKRIAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0DVX3</accession>
    <name>S0DVX3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hyphal anastamosis-8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_03030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679025">
        <property type="protein sequence ID" value="CCT66719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428800.1">
        <property type="nucleotide sequence ID" value="XM_023574831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DVX3"/>
    <dbReference type="STRING" id="1279085.S0DVX3"/>
    <dbReference type="GeneID" id="35396512"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_03030"/>
    <dbReference type="HOGENOM" id="CLU_044229_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT66719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53369" checksum="82BC4A91069A1BA6" modified="2013-09-18" version="1">MAGPEDRRRPAALNLASARPGTSESSSSDGSLKPRTPRFAEATSVHSPVEARSPFADPEKSHVAQPQPADVGFGYIGRRESIPVPMTPKTPLKSAMKVPGTPAHLKNPLSPTFREEDILEKREASTDKEQARDVKIKARVRLAKFALRGVNFSCSLIILAMLSASFTIFNATKALPDQSKMPSWAKNTSAWPQKLVLAMARVSLVACIVVFISYCRGGHRRAEKVGTYYTMFAIGWFILALILWVVTAVIFQNSRNNSGNQDMWGWSCVNNHRSEVFGEKVDYALVCRLQNWAMICIIIEVVIEVLCILLYSVVFYRYYTKRRLFKSMDMRDRARSDLYLAQLRSQSAPNTPGFGPKSPALSAYAMSPRHPPAAYRNLSDISENPTTFTPGTQFAEPKSQFAAQETGFKLQAPPMKAPSATPKLNQSAFTPTEASPPAIPTVQVSQHGPVSTDEPTYEAVPIPGAYAGQAVRSPPPTQTHFGQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0DWM0</accession>
    <name>S0DWM0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT66896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023428977.1">
        <property type="nucleotide sequence ID" value="XM_023575705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DWM0"/>
    <dbReference type="GeneID" id="35406520"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13064"/>
    <dbReference type="HOGENOM" id="CLU_088301_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT66896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="205" mass="22293" checksum="011675FA8918D7AA" modified="2013-09-18" version="1">MNNQTRGNSRRGRSRPGRGQYFVGNMGHPQNGGGPGQAPVPFPPPPRPPVVAYPVYGQVPWVTPPQPYFYPPPVAYQNAVSLGYYPYAHHVPAYMPPPPQGQVDQAAQVPGQNHGLRLRRRHRSRVQPRGRSNGRGNRGQPNRRQVGRDNSSARQAPVTEGSSSEAGAEGRNSLAVLPVPLEQSSDLDGRGVKQEDTEDESTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXB2</accession>
    <name>S0DXB2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429247.1">
        <property type="nucleotide sequence ID" value="XM_023576034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXB2"/>
    <dbReference type="GeneID" id="35406811"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13357"/>
    <dbReference type="HOGENOM" id="CLU_997798_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="253" mass="26852" checksum="B861E38A8BB15A75" modified="2013-09-18" version="1">MTECFSATQTSFGQAEPTQGADKYWTVEMPECQDCLCTDCAYTNTYTTTLDVFSPSGIAKFPYQVKEVYRGMSAMPADATPTAVPYGFTSGVETCSICGDEPVTATMTYPRGGSPYQESVPTATLAAQSAFERPSTLRTQVADTEATDSPSNENDIRPLENTVLEHKAIQYTGQGPDQADFVKFSLASKSGPAARDTGSKRPGNPSRDINSYAKMRFDAAEAAPSKDVDGAAASKHPPAGVAIAVLVPIALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0DXP6</accession>
    <name>S0DXP6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_13508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429387.1">
        <property type="nucleotide sequence ID" value="XM_023576201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DXP6"/>
    <dbReference type="STRING" id="1279085.S0DXP6"/>
    <dbReference type="GeneID" id="35406962"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13508"/>
    <dbReference type="HOGENOM" id="CLU_098333_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT67306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="156" mass="16838" checksum="6A7B6B997E657621" modified="2013-09-18" version="1">MSQRQQQRSAPAPSQTQTETPAQTPETREQAPQILRLRGAHASNGRSVQWAEDVVDNEGLGRKSSKVCCIYHKPKAVDESSDESSSDSDSDSDSGSDRDGAQPAGGKRQSCGHEHGHSHGRGRRNGKGKEKRAPSPNAYEKVPKPKPKDGPSENKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0DY65</accession>
    <name>S0DY65_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_13705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429570.1">
        <property type="nucleotide sequence ID" value="XM_023576420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DY65"/>
    <dbReference type="STRING" id="1279085.S0DY65"/>
    <dbReference type="GeneID" id="35407159"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13705"/>
    <dbReference type="HOGENOM" id="CLU_033097_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018830">
        <property type="entry name" value="DUF2434"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10361">
        <property type="entry name" value="DUF2434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT67489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="581" mass="66811" checksum="EAF5FD3CF609274A" modified="2013-09-18" version="1">MNGLIEAFAHISARAVNEWPEGDKGNSSDTILGGVHFNLTTLKYFNYTFYSNNTISNNSKCYLTFAPYTPAYVFPNGTWTNATKCYSAIENIKTRGFVGIGFAVAFGIALVLNLTVLAKHGKLYVPRDSRFYPIGRRWQWYWALFSAAAALISLFVGIDIDRYYLQELPITVNVFFWYLLCMGTVAMTWEAVRHWGSWQERQYVDPNPFILRDDDRRSKVEFWLPLWFYLWLWLNFFMVVPRSWKFTQLQHSEEQTLAKAVPGATNTRFKVGAFCLVVAWLTIVFSLHHSIKHYKPRHRGIVNRAVGFLRYIPFRFWLIIPLSAATIAYQAFISWEFDYSIVKYNGNIPVIYCWGFLPTLLILYIQYLYGFFSPNEDKSLIRKRRERGEMINRELGIVNKPAWWHRVRGDHLLSFKDKLTRNVHEIGGGRATGRRIEGDAERDLREEALAAARDDDIEMGHIHRPLDASNNPRSDRAVTASISSNASRSFVQPYTGKNERRRHERNMEAVAGILFPNNLAEDRARREAQLGLDGPPPPPYMDGQGRGRSSGRPGSTGRSNSTETNNSINAPPQQIRSMLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>S0DYB0</accession>
    <name>S0DYB0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="10">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_13651</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="10"/>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429521.1">
        <property type="nucleotide sequence ID" value="XM_023576360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DYB0"/>
    <dbReference type="STRING" id="1279085.S0DYB0"/>
    <dbReference type="GeneID" id="35407105"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13651"/>
    <dbReference type="HOGENOM" id="CLU_011302_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT67440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="604" mass="67209" checksum="01D0A0D68DAC0370" modified="2013-09-18" version="1">MPEIGLGESIPPDTAHAVSVSLPTWKANVGYEEGEDWVVNRMTTGYPRFFVHKGIQAFAKDIVDRYGSPGQQAMLFPTPRVANRCQDFILQRISPELANQVRIIDFALDKSKELSPVLTKLTSTISAVVYPSEVFPIAKQYWQHTGEGTSSRRAEFCHGLFKDDLLIPAARSRTPPEASQGRPFRGPRRYTRPGSIDGVSSAAPSTPKQPSPETPVESLESSRFLEERFGRNLDLSMVERAKSAIRRRIAGAMAHDVDLNNGPLPAMTSNTRGMPNLEENDVYLYPAGMNAIFNAHRALLHAREPAQSINFGFPYVDTLKILQKFGPGCLFYGHASAEDLNDLEARLKNGERFLGLFCEFPGNPLLTCPDLTRIRKLADEYDFAVVVDETIGTFANINVLPVADVVVSSLTKIFSGDSNVMGGGLVLNPESKYYRTLKTTMNEIYQDNYWPEDVIFMERNSRDFESRVVRINANSDAICEVLRTHPLVKSIYYPKYNDSKPHYEKVRLPDGGYGGLLSVVFQQKEHAQAFFDALPLAKGPSLGTNFTLASPYVLLAHYQELEWAEQFGVDPYLVRVSVGLEETTELQDTFTSALKAAEAVSVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0DZN3</accession>
    <name>S0DZN3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_14643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429946.1">
        <property type="nucleotide sequence ID" value="XM_023576600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DZN3"/>
    <dbReference type="GeneID" id="35408023"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14643"/>
    <dbReference type="HOGENOM" id="CLU_010839_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="136"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="7"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT67865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="584" mass="65259" checksum="30010DD16B002DD4" modified="2013-09-18" version="1">MCIYRLKPRNRARKAHKSASTEISNSETPEDSHTNGVYPGAIIASNTGGEPGIHEQLVYGPTSTFAFLQTLHNELDHRRTHTSRNKCQSLDAFTKRTIFFGLPSRVDPLLLPLQQRMEDILPRSTAIRFLQAFEKYSSHGLPFINIDRTRVSLDNPYNVRVNDTSTSQDKALLLMILAIGALSTSETDTAETLLIHAKREVALFDDVATLPIDQFCLLMSDYQLNMGRPNAAYLQVCSASTRALAMGLHARAEGDIGREDLQTRLTTLWATYFQQTWICFIVGRKGIFRRSDISCDYPDNEPMLIDLCNLAAIQEQATSCPNGQKYCTLSQMYENTRKLHLQVWGVCEDLWFGPSPLRCQGSGADEMARLLVCNVYCHFIHTVYRPFLVAESALRAFGQLERANAIWLRQACRYATDAAEDSIIITHQIFKASDTKGMRRYNSFFLETSCAILLYASMGHPSKHPHHRDIVGLAIECLELMVVDDPVTNAILHIQKLIDAIEGYIHGPFNRGMEDPSSHADVDQRQNSDQAQGVSVSLPSENIMDSTTSPISGSADYMFSGFLGLLPLDPSFVLMVEDGTGMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0C5</accession>
    <name>S0E0C5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to SLY1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_07101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430404.1">
        <property type="nucleotide sequence ID" value="XM_023577315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0C5"/>
    <dbReference type="STRING" id="1279085.S0E0C5"/>
    <dbReference type="GeneID" id="35400578"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07101"/>
    <dbReference type="HOGENOM" id="CLU_016216_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035543">
        <property type="term" value="P:positive regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT68324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="704" mass="77079" checksum="7288B3C909A80B1C" modified="2013-09-18" version="1">MATKGNSLRDRQIASLKKILNLNESVESSEADEAHANGLLAPVAPILDADGNPIWKVLVFDDLGRDVISSVMRVSDLRSMGVTMHMHIGGARHPIPDVPVIYLLEPNAQNLQAITSDLQKGLYTPAYINFLSSLPRVLLEEFATQTAAAGTSEHIAQLFDQYLNFIVAEPDLFSLGMQKEHTYWALNSANTSDEELDRVVDKIVSGLFSVIATMGVIPIIRCPKDGAADMVAARLDRKLRDHILNSKDNLFSGPRTNAASSTHSSRPVLILLDRNVDLVPMLSHSWTYQSLVHDVLNMKLNRITIESPAEEGSPSKGPTKKGYDLTTNDFFWAKNAGSPFPQVAEDIDAELTKYKEETAAITKRTGVTNFEDLQADTSASAQHLKEAITLLPEMRERKGILDMHMNILAALLTGIKDRQLDNYFQLEENVVKQTKPQIMEIISDSTKGSEPVDKLRLFIIWYLSTEQEVSRQEFEGFGKALSEAGADVSCLPYVRQVRATTKMTQLTTINSTAQPAQTSDIFGRFSSMSSRLTDRLKESGVPTGLSSNFESLISGVKNFLPADRDFTVTKIVESIMDPSSASSSAIAKTEDYKYYDPRSANARGSMPAPSAMRSGAGATPGGMPGSQVSGQTASFGQRRQGFSEAVVFTIGGGSIDEYGNLQEWVSRAGGDRAKKRVVYGSTEMMNAAEFIKEELDTLGKELSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E0E0</accession>
    <name>S0E0E0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429183.1">
        <property type="nucleotide sequence ID" value="XM_023575955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E0E0"/>
    <dbReference type="GeneID" id="35406740"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13286"/>
    <dbReference type="HOGENOM" id="CLU_100672_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013869">
        <property type="entry name" value="DUF1757"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38636:SF1">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38636">
        <property type="entry name" value="PROTEIN CBG20488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08560">
        <property type="entry name" value="DUF1757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="169" mass="18271" checksum="01F6D64F25A92634" modified="2013-09-18" version="1">MSRFFPHTPYAEDQPLARTILTTHVIVRAITLSSIIATGITTTHHLVPFLRPKPPTLAFFPRLIRSASTGAVAAVGVGALMTISRMRGREEVEWQDRSWRLLENQGQLETDDWTTVGAGAGAFIGANALKGWRGAVGGLGLGSMGGALAWMAWRFGVNGGKFPKKEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1A3</accession>
    <name>S0E1A3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_07313</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430606.1">
        <property type="nucleotide sequence ID" value="XM_023577551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1A3"/>
    <dbReference type="STRING" id="1279085.S0E1A3"/>
    <dbReference type="GeneID" id="35400790"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07313"/>
    <dbReference type="HOGENOM" id="CLU_032621_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="409"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT68526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="451" mass="51193" checksum="357EE8A0169A4037" modified="2013-09-18" version="1">MADLNPPKTAVQDQDINPWSVEGAQGENGEVAAIDYDAICSKWNTSKIDHALLERFEQVTGKKPHRWLRRGLFFSHRDFDKILTKYEHGEPFFLYTGRGPSTGSLHLGHTIPLEFTKWLQDVFDVPLVFMLTDDEKALFKDSLSFEDTHKYALENAKDIIALGFDEKKTFIYSDLEYLSHHFLTNAYEFSKLVTFNQVRGAFGFDGSANIGKIFFPAVQCSAAFATSYPEIWSDDPSPVRTKALGKIQCLIPMGIDQDPYFRLIRDNAHRMKNPSPKPALIHSKFLTALQGAGGKMSSSNPNSAIFMTDTAKQIKNKINKFAFSGGRETLEEHREKGGNPDVDVAYIYLTYFEDDDEKLQKIYDDYKSGTLLTGELKKMAIEALQSVVESFQDRRKAVTDEVLRSYMKPRKLQWGGNPSPKPKESKPKGEKKKENVDNKTELPDRTREKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0E1H9</accession>
    <name>S0E1H9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to L-fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_07422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430701.1">
        <property type="nucleotide sequence ID" value="XM_023577671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E1H9"/>
    <dbReference type="STRING" id="1279085.S0E1H9"/>
    <dbReference type="GeneID" id="35400899"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07422"/>
    <dbReference type="HOGENOM" id="CLU_006746_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="778"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="813"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="841"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="5">
        <location>
            <begin position="36"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="929"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT68621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="953" mass="104846" checksum="43FAEBA7C9800CE8" modified="2013-09-18" version="1">MSDSASTDDGGIPDRGPVVFAVTTATLVLATVFVVARIVSRTFIVRNVTWDDRVMILAWLFAFFLSFTICFGVHNGLGRHDENIDPNRLPALRRCEYVFSILYNPALMATKTSVLIFYLRLAKHTQRVLRFASWLTLAVVNIAGVILTFMNVFQCRPTQAAWDVNYDERAKCIPLLTEFICSSPVNIVTDLAILALPIPVLTGMRLPSRQKTILVLTFTVGIFVTVVDVVRIYYLQQAITAPTSTTADPQSRFGGQTDFAWNASRSLMWSAVEVNVGMMCACVPTLKPLVLKLLPSMLYDPNGTRASTPKGPNDSDTPSTGHRASIQQPPPVAQTGAQPLNANAPMSAMEFLTTPFDEPDPTRPTQRGYQSNGTFQTSTTMTSSTGTVEGVYFGFVNMTKPKSMLKCNKKQSFKYCTIVSILFLLWGISYGLLNTLNNVIAKVDNMTTAETLGMTSVYFGGGYFFGPLLVGEWILRRDEHNRSRRHKANGHDSVGGFKVTFIVGLCFYGIGTVIFWPSAVTQSYAGFMLSNFVVGFGLSILEVGANAFLILCGPPEYGETRVLMAQGIQGTGSVLSGLLAQKVFFKGIVEQSNATSMTLINVQWTYLGITLLCVALGLFFYYMPLPEVSDRELEQSTKHLPMDPQKKRGGLQLRTWSLILAVVAQYTYVAAQECFSIYFRSLMISILPNTPNTGEQATEGAGDIPNPDKPPGIALSIPDYLLIAHTAFAVSRFMAAGLAYLSVYRSRFPRPRTILTACIAGCFVFALLPVVVRPPNPNLLVIPIVLFYFFEGPIYPLIFAIGLRGQGRRTKRAAAFITMGSSGPGFFPFVMYGIIKHGGTVRTAFVVVIVLQAVCMSYSVFLQFISDAKQLVDPCPAVRDALRQPDEEMPSPMETAIVGRARRQSTMKEKSQGFLDKVSHGTKVISARFLSTRRRSSQPSIHQCEDSRDNAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2Q8</accession>
    <name>S0E2Q8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_07904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431055.1">
        <property type="nucleotide sequence ID" value="XM_023578209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2Q8"/>
    <dbReference type="STRING" id="1279085.S0E2Q8"/>
    <dbReference type="GeneID" id="35401381"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07904"/>
    <dbReference type="HOGENOM" id="CLU_012349_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="608"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT68975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="76343" checksum="5BACBF962E295831" modified="2013-09-18" version="1">MVVDPWAQGASNNSSHHGHSGKPGDKIQEWSSLIGIVTAIVGNVLIALALNVQRYAHIRLHKQRSRNRKRAKEALKHPHPGDHGGSYGTIGGGSDGAGYQNGHGTSTNDGDRMDESHETDPLTGSFHSEASQSTDSKEDDTSSSYLKSPYWWLGQVLITLGEMGNFLAYGFAPASIVSPLGVVALISNCIIAPAMFHEKFRQRDFWGVVIAVGGVVTVVLSAKQEETKLNPHDVWDAITTLAFEIYLGVTIFLILVLMWASPRYGRRTILIDLGLVGLFGGYTALATKGVSSMLSSTLWRAFATPVTYVLIVILLGTAVMQIRYVNKALQRFDSTQVIPIQFVMFTLCVIIGSAVLYRDFERTNAEQAAKFVGGCLLTFFGVFLITSGREQSHDDDEVLSEDDDFEDTIGLASQEGNGTASYQDGQGFSTPKSQSRRSSHLSGLNYPDAQRVLKAAVTPHQDNNNLPSAKALSSQMSPGQETMASGFPWNDFGGPSTPPGRGVRAYSTDSVLAPPGTAGSAAFASHPTTPMRDALAADGSLLPRPQASPSKPGGTGSRSRTFISPSPLSSTVTAVVKDAFLRASDDPSVRQSSMRRIRSTIRAGLFFNEDDENADPENNSRSNTLPAQSAAPVSVENLPGALDEAEGPVGEDDLVRRRSRSVSDTLGDFFGVRRKKRHDGYFASDVEDVAIGGATPGQDRTDRQGDCREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2W2</accession>
    <name>S0E2W2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431226.1">
        <property type="nucleotide sequence ID" value="XM_023578413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2W2"/>
    <dbReference type="GeneID" id="35407815"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14363"/>
    <dbReference type="HOGENOM" id="CLU_1786943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT69146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="174" mass="19339" checksum="AF026E58C296A2B6" modified="2013-09-18" version="1">MPENQEPQTWGSQITYVPVRLVKDVNTFKAALRDHYGEGVTHPIKSSHGEEAHYEVTAPQASTGPANLVKTLQDEGVLKEEGENNLYDLAFKKHYRTMATYGTQMHDIPIRLIGDETAFERAVEAIYPNGVTFTYHRAGTTTSPWPVCNVQANASTGPADLVKHLQDAEVIMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E2X7</accession>
    <name>S0E2X7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431294.1">
        <property type="nucleotide sequence ID" value="XM_023578496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E2X7"/>
    <dbReference type="STRING" id="1279085.S0E2X7"/>
    <dbReference type="GeneID" id="35407741"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14289"/>
    <dbReference type="HOGENOM" id="CLU_026305_3_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="1">
        <location>
            <begin position="241"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="435" mass="49023" checksum="2E2AF1659C36E19A" modified="2013-09-18" version="1">MQVKWIDRKRVTRDFKKLLYRLNRKDYQEALETISKGITSLEGLTQQSSFYRALCSSILCTDSHDVSLELATRFIEVGHECDVEKIVQDAQFKLAISFQVVKGPTSKVFWGEVSIKAMSLSTTNPSAPCVLAAKSKSAKRVSFGVNQALSRLSLMEPATELNVKTVMAILTRPATDFAYIKYPEESSGMQTISPIDLCLTLKKAHQERPAYYGHLIDKEYNYRHFQVCPLGPVINSDGWSIVTLEDVLGGKRGLRPLISLAEKVRLALVIASSVLQLSKTPWLPEALTPKNVHFFRRGNTLSYEHPFLQRRLPEYPLKRLNSTADTMGYSLSSNPTLLALGMLLLEIILGSSLKKLRLPDEKGLDDDGLIQDLTVANRMLEQRVSLIDPAYKTVVERCIGCTESKELDEDDFRHTVYNGVVMELEAIWDYTKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0E3I4</accession>
    <name>S0E3I4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to RNA-binding protein pumilio</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_13467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429349.1">
        <property type="nucleotide sequence ID" value="XM_023576156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E3I4"/>
    <dbReference type="STRING" id="1279085.S0E3I4"/>
    <dbReference type="GeneID" id="35406921"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13467"/>
    <dbReference type="HOGENOM" id="CLU_009803_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="382"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="488"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="680"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT67268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="769" mass="84930" checksum="F4BD3EB78FD0B041" modified="2013-09-18" version="1">MSSAGSTGVSPERTVPIFAANVHAENSNPLPLTPGSKEAGKSIPAKKNIAALSTSKLANQGLPKVKQNVYPVDKLLAKLSEQQSALNQQNDANKLRDETNQYARAFDHASSSNSLPVTPATDAFPSTAPTTRPASATLDEARSESEEVMRLKLQLAQAQNEISKLDQELAETRVVKTTAEVPPFGTRGPVYPPRENTWGPPDDSHSDTSDAMSASTFNRTREIWGNQPIFANTVQAPVIEPTPGKWLGGRVFSQPCSEPTGTPFPVMEGYRSERLTPDTEMMRSNYGRRGNRFEGRFNSPQPFGPGYGGGLNSPMNQSDYMGSPAPGTPLNAPQGLGPMGVYPPYPNPAGTPLSPHASEFTTGSGWKNEVGLPALYSHRTLNPRQVLAPDDQTYLAPTEPLNYRRLLDRNVNCNWKYIVDKIVCNNDQQASIFLQQKLKVGTADQKFEIVDAIVAQAYPLMINRFGNFLVQRCFEHGTPDQVINIAEAIRGNTLNLSMDPFGCHVVQKAFDSVPENFKAIMVHELLRRIPETVIHRYACHVWQKLFELRWTESPPQIMKFVNDALRGMWHEVALGETGSLVVQNIFENCLEEDKRPCIEEVLANIDIVAHGQFGNWCIQHICEHGAPPDRSRAIDHVIRYAAEYSTDQFASKVVEKCLKIGGAEFLGRYLDRVCEGRRDRTRIPLIDIASDQYGNYLIQWILNNASPQHREIVAAHIRKHMVSLRGSKFGSRVGMLCTNHAVATRPGPGAGPGMGGRMGPGPRYNNGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4G7</accession>
    <name>S0E4G7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Related to O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">FFUJ_05543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431721.1">
        <property type="nucleotide sequence ID" value="XM_023578765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4G7"/>
    <dbReference type="STRING" id="1279085.S0E4G7"/>
    <dbReference type="GeneID" id="35399022"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05543"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495546" evidence="10">
        <location>
            <begin position="17"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCT69641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="478" mass="54474" checksum="F712B5CA4A097B7C" modified="2013-09-18" version="1">MSTSLVLVTAIFTSLSFLLVKHIQRSKIPPLPPGPKGLPFLGNIRDLPPPGTLEWPHWQSHKEKYGPITSVTVLGQRFVILHNRQVIMDLLETRAMKSASRPKLVFAGDIPKSITRFEPIQELEILKLLKRLHKDPKSQNLPDHLNQLSGSIMLRILYNYETDPSKSDHIVTTANLVMEEFSQATTPGAWMADFIPWLRHIPDWMPGAGFKKTAKLFRQHLLQNVLDPYQYVKDQMANRKDNVSYVAGLIKDIHRKIDAEEERVIAWTAASMMNAGTDTTGATLLAFFAAMLLYPNVQKKAQEEIDRIIGDSRLPSFSDKPGLPYITAIVQEVLRWHTLAPMGFPHMTTEDDTYRGYFIPKNTLLFPAVASLTHDPEVYHDPMEFKPERYFEPYNEPSPSDLVFGFGRRACPGRWIAEQTLFLSIAQTLAVFEIKKETDGEGNEIEVGYDQLPGVISRVKPFPHRIVLRSEKYMKFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4K4</accession>
    <name>S0E4K4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431650.1">
        <property type="nucleotide sequence ID" value="XM_023578680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4K4"/>
    <dbReference type="GeneID" id="35398945"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05466"/>
    <dbReference type="HOGENOM" id="CLU_102266_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="237" mass="26071" checksum="08C20F22994FD8CA" modified="2013-09-18" version="1">MPSLADLGVMDHMSRSDDDMDDNSSTCSYYSLSDVDDISFKKIPAHEVRKQSEQVPEFSPFSTYPHTFRNSEALPLKVAGPWLEYPLCLKGKYISSVGMNPGPARVIINPSVPGGHDVIYHPTKWEGRFLQAKYRPKGYRAKISGCTAIPTIPSPPSSPPPSPSLSPYPFLYFSPPASPGFYGASPNGLIASQQAFALAAQQHQIAWQQQSLMASCMYPQVMGYNGVVRGQSLLEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0E4L1</accession>
    <name>S0E4L1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">FFUJ_05477</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431660.1">
        <property type="nucleotide sequence ID" value="XM_023578692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E4L1"/>
    <dbReference type="STRING" id="1279085.S0E4L1"/>
    <dbReference type="GeneID" id="35398956"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05477"/>
    <dbReference type="HOGENOM" id="CLU_031639_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="326"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCT69580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="461" mass="50197" checksum="5B09F8C9D1B2F02D" modified="2013-09-18" version="1">MAVPQRHTPPMEELRQFYVGKSIHDVPKPAVILDRARINRHCQSMLNAVETLGLGFRAHVKTHKTIEATHLQVGQGSGDVKLIVSTLAEIEHLLPLLKEYRNAGRRLDILYGLPLPRSQISRLAALGAELGQGSISVLIDHPSQLDSVKTFSRHAKFPARVFLKVDTGYHRAGLPPTAMNKNGLIEVLAQLEANGEAELLGLYSHSSLSYKDTTAEQAMANLEGEIQGCLDAVNAHARLFSKDKELVISVGASPQVTAVENLVTSQGDLPPAAQSLRKSIKALTMGNPGGLQTRLELHAGVYSILDMQQVSTNSRRELGSFEEEIAISIIAEVCSVYNDNERSQPEALVAVGCLGLGREPCAAYPGWGVISQSSYKKTSDNARRLIINRISQEHSIAAWEHADGEDMYSLPPVPLEVGQDVVIFPNHACVAGALYGWYLIVESSEGDTTKIVDVWVRASGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5A6</accession>
    <name>S0E5A6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_05877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432030.1">
        <property type="nucleotide sequence ID" value="XM_023579138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5A6"/>
    <dbReference type="GeneID" id="35399355"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05877"/>
    <dbReference type="HOGENOM" id="CLU_021109_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT69951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="803" mass="88439" checksum="E2A51CC505392F62" modified="2013-09-18" version="1">MEGYDDNDARCLPRMPRIFTPPDTQPEVVLFSAAADDESSTKSKTLHELATCNTETDDTACHDKEEAEAGPSNAPHSTLMSPGDGKAPSRVFTIKDMRSSQSSQPSNDFVSANDYVPDETIQRLKDIAHRVHALNRDPNEDQISSSGETTPTGRSLEVNSFKSSAPDQAPQPLTRSRLRSIPDARPNNIGAVYDRLQDTNNGSQLATHGSDTSRPADLDTNSINTNAHEAASEDEHRAYYIFDPRSNGSAYYMYRGTEENEGFKIERVSFKFSARGPGVRAYYYLEASDKDQGVLRHGSHETLWWLDPSQVPAVIIDTESSASREAEAEAGDPLYAGEEATQSIARKVSDRLQKIRHLREHLHVINGKGQQVPEAKGLYLIGDKDIRDVVSIVLDETLKNGHIELPKRTPTTTGSSESRPLPRLDENSNAILVPSPMVIDPATTINLPSTSYTNINAADMQVHTKTRGGASEATTTVVTRRSIAEITWSRAYPANYDSSTRTHCRTVSDCCSPTHGGSRSCPDDRRQSYQRLTKDESVLRHYATPKSTAEILADIMCNKSFEQQLRVSDGTVITSFPRLFSRDCTTDLTLQTESDQSKKHTPPTLYQDGVDAHCGVEQLAASSSSVEPSNTHSYSNPLFAANPFRAHPTKLTAAGRHLPTPLAAERKLSASLDADTRRRLSAHIAGNEEEMIDSQNGSRQSLMDKIKQGGHKLFHKNHFRKPTGGAPIRMAENDISPGGFLRSRDSIAREPTPEPPKPDDEEIYEAMEGSKLNVPHPREGACSEDNQPHECVNDLSSRDISLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5C2</accession>
    <name>S0E5C2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to zinc cluster transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_06005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432148.1">
        <property type="nucleotide sequence ID" value="XM_023579281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5C2"/>
    <dbReference type="STRING" id="1279085.S0E5C2"/>
    <dbReference type="GeneID" id="35399483"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06005"/>
    <dbReference type="HOGENOM" id="CLU_041953_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15486">
        <property type="entry name" value="ZIP_Sip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT70069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="362" mass="40235" checksum="88E72DB87D4CADBF" modified="2013-09-18" version="1">MGSGSLPSPPAEDHKSTLSRKSTSSSSKSVKPVHRTSKRASSSAATIHHHDHVTHTTGMDGRHKRVWKACERCRMKKTKCDGEFPCKRCKDDGLVCTAGVRKKMEYKQLPRGYAEVLENTQFALIATVHKLYSMVRNNQSWDLGEPELNDRGQPVIHNIAQKLGCIRPNSDIDLPVHSVFPEDEAGMAELARQLEDQQKEHEPAKETIKDTDSSVCNRTERASSSELDHSDFEHDYRRAAFGNTNAMTLSPQSFTGSADFDFAPPPPEIDASSLFPSQSPAMSNFPAWAMTKPQPSDLTMQFLQQQQQNGMMANMDLLNQGLVESEFGTIKPHVLSCPNPEVMLGMGDPMIYSGYDGEPMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5D9</accession>
    <name>S0E5D9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_14869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCT67823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023576860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5D9"/>
    <dbReference type="GeneID" id="35408247"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14869"/>
    <dbReference type="HOGENOM" id="CLU_035151_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT67823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="467" mass="54560" checksum="B95B74FDCF5A1109" modified="2013-09-18" version="1">MDLFDRLPAEVRIKILGSIPSHATTARLIRASPAMLAQYTTTESTYVREYLLQLVGTDANDHGLLQDALAIIYLSETDDLDQISDILREWKAKTLPLPFRRGDNDTTTKLRLLFERMGEFIDDYLSKATAQNTAEAYLRPPRRTYIDTVDPQLITLHDLNPQERLRLFQAFIKFEVLCNFSNERVHHALTKLRPKLKLGLSSWEKKALMCVYEYMKASYSAMFVQYAGAKTFKDYKKTCDSLRRVEREDSFFVETMCYDPQYPFRRYKSLENAAYYPKALPWCGFDVLSHLMMEAKAEHQPMRIARMCSKYDRRSCDSAHHIVSRVEEMQSREDSAQLNRLAGRPNRTNTEVVQVKRMRRTIHQQRAWAFFDDARLCPGQEAHFPTEEEVTTEVARLEAERKMNTRKQWQEYFAKKRSNPPRYKSPLKLWDRNDHTTAEKTLKDCEANNGGLVPPPFFALPEARHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5F7</accession>
    <name>S0E5F7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679026">
        <property type="protein sequence ID" value="CCT67838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023429919.1">
        <property type="nucleotide sequence ID" value="XM_023576491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5F7"/>
    <dbReference type="GeneID" id="35407926"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14545"/>
    <dbReference type="HOGENOM" id="CLU_2184191_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT67838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="109" mass="12121" checksum="AB05B7B9119D6310" modified="2013-09-18" version="1">MEDLNDDSKSIKLVDAMLPGFIGTIFSTSNRNLRSMKTILDKEGIVVDKLENSPYIPENVTGKLWDILAPKKPSQSSRNHKSHANQDPKVPEVNDQDDDLSEQLGSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5G9</accession>
    <name>S0E5G9_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_05871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT69945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432024.1">
        <property type="nucleotide sequence ID" value="XM_023579132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5G9"/>
    <dbReference type="STRING" id="1279085.S0E5G9"/>
    <dbReference type="GeneID" id="35399349"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_05871"/>
    <dbReference type="HOGENOM" id="CLU_069491_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="CDD" id="cd20446">
        <property type="entry name" value="Tudor_SpSPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="99"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="278" mass="31049" checksum="604B355B66301DFA" modified="2013-09-18" version="1">MSSIAEIEQEKKTYQEQFDIVLGQLRDDPDNLELKALKDELNSFIDLLNEQIAELKPAQAPKPAPREPSPPPQPEKWSRENHPAFKKAAPVEEEKQAPVNYQVNDTILAKWVSGDKAFYPARITSITGSSTDPIYTVKFKTYDNTETLRSRDIRPVSNKRKADGTPTTSAPATPPAPGLVSSAGATVYPEAKKAAEQDGEVKPPKAKKIKAKKELEKNKNKWQEFSAKSKFGKNQKKDSMFRTPDGVHGRVGFTGSGQAMRKDPTRSRHVYQMNDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0E5S5</accession>
    <name>S0E5S5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to Som1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_07982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431127.1">
        <property type="nucleotide sequence ID" value="XM_023578296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E5S5"/>
    <dbReference type="STRING" id="1279085.S0E5S5"/>
    <dbReference type="GeneID" id="35401459"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07982"/>
    <dbReference type="HOGENOM" id="CLU_008468_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="580"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT69047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="816" mass="86691" checksum="576F18FC734F1EB4" modified="2013-09-18" version="1">MANMNPMGGPVGGAPMPMMNNGVVNPQAAAAAAAASRQQANENQRSILNTYIYEYFIRMGMYDCARSLLSSDQQVNVLGKDGANRRRDENGNIINGVGDDPMDTDSKDDIDSKLPEDLPPPKLPMPASDTSFLYEWFSVFWDIYYAQRAKSGNNTINQYVQHTQQQSRLKQNQQQELLRGMRPDMAAQQYQMMRNMQNGGMMNMKQGNLARAAMANSQNNPQMMLQQAKQNQMQRDPSGMDGQNRPSSPTSGENAPSPSKRQRIDGAPFNPNQPGMMPNGRPGQGMPGQQMPGGANTAAAQQTLLANGINPHSLHPQQLQNFAAAPPAAQQKSIATYSQNLQQHHGTQMGGKQMPNAVPQGQGSPMMAQGPDGTALNAFYNPGEMGGPGGIRAGPGGPQNGGGSNHALQDYQMQLMLLEQQNKKRLMMARQEQDTVGGNGMPREGQPGQPGGPPGPNGQFPDTSPQAMRPGASPNPAEQMKRGTPQMNNSGIPSPVPEGGQSRGSPNPAMNFMGNQMDPNMAPHFFKQQMDGNMGGQPPMNGGMRPPSSHPGAPFNGQMNQQQMMAAARQQQGQPGQGPQGNPQQWQQGPNGQMVPQQMQQQSPQIQGTPQQRSMPPPQAPPAGANGANSRTTASPQQAAAAPPTPSQTNKAAPKKKKGETAKDKRAAANKKANQNLSNAGATPSNENNESQETPAPATPIQNANAANFNKNGQAGNTGQNGQPTTGPAANAPAAATTAPPPQPPAPQHDPNQMMGMDNSFGPLFDGGGMELANPLNSGDVLNDFDFDSFLHDQDGDNSAFNFTEAFPMGDEIGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>S0E694</accession>
    <name>S0E694_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">FFUJ_07810</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431332.1">
        <property type="nucleotide sequence ID" value="XM_023578103.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0E694"/>
    <dbReference type="GeneID" id="35401287"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07810"/>
    <dbReference type="HOGENOM" id="CLU_001975_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000097">
        <property type="term" value="P:sulfur amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000051">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.480.20:FF:000012">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="20">
        <location>
            <begin position="795"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="233"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCT69252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1536" mass="169034" checksum="73D5A85F72FFE8E3" modified="2013-09-18" version="1">MDAASQHQIKTPEEAVARIAYLSSDVVVSVQPAIGTDSEFSSHLNRYASRKDSSLVAQSADTVPEIIPVRHNTDPLLSVYTPIRAGKLVSVTTTSNILLPSVSHLYKLANYPVVLHVSLQPRTFPDYSVITAVRNSGFTFVQSETLQEAQDLALTAHALAVRTGKGVIHFFAPSTSSKDKPIAIEDAAVVRDVLDIESVRRFQAGSAPSSQTGIYADDGHIAVSSDHDAPAVNGAAASGNLTVPPSANASKAPSAGTSVKSSQDSEASTPVAPSSVATTVETAPPQVTSEDIYKSAGRIWAQLKASVGREYSAFEYSGPPDAENCLFIFGSDAGAFAQAIDEARPEEIFANTAILTPRLYRPWIGSRLVEAIPRSVKRIAVLEQIHRKTTKWGPLLIDVLTSVKSGPGGVEAIVGHQLGYIAPDVVVQALRGVLQNLTAEKPIQNLEVGKKEVWKEPTGYDLQTPQLETAYTKILDQLFGKRAYIANAIKSSTTGLSPNVAASPEFGFGSLLARKQRRGQFVSQVKDAATNGSFTTDAPKSWLARWAMNADDATKSTEIADDVIARLETDGSSLAAELLSAKGLFRKESLWLTGSDAWSYDLGNSGVHHVLASGENVNMLIIDSTPYSERAAADANRRKKDIGLYAMNFGNVYVASTAVYSSYTQVLQALLEADKFEGPSVVLAYLPYFGETDSPLTVLQETKKAVDTGYWPLYRWNPDNEKKGEPNFSLDSELIKQELKKFLARDNQLTQLAAKEPKFAAALVKDFGSEVRAQQKRKAKDAYNQLLEGLLGAPLTILYASDNGNATTLAKRLASRGRARGLKTAVLAMEDYPVEDLPTEENIVFITSTAGQGEFPQNGLPFWDAIKDNTGLDLAAVNYSIFGLGDSHYWPRKEDKIYYNKPAKDLDRVLTNLGGKHLIDIGLGDDQDPDSFQTGYQEWEPKLWTALGVDKVDGLPDEPPPITNEDIKLASNYLRGTIVEGLNDPTTLAISASDQQLTKFHGTYMQDDRDIRDERKAQGLEPAYSFMIRCRLPGGISTPKQWVQMDDIANELGNETMKLTTRQTFQFHGVVKSKLKPAMQAINRALMTTIAACGDVNRNVMCSSLPTQSKYHRQVFACSQLISDHLLPSTTAYHEIWLTDDDNKKTQVAGDAVQDFEPLYGPTYLPRKFKITIAIPPHNDTDVYAHDIGLIAIKGEDGNLAGFNVLAGGGMGATHNNKKTYPQTGRMFGFCKTEDVHIVCEKIMLVQRDNGDRKNRKHARLKYTIDDMTVPVFRSKVEELWGKKFENERPFEFKSNVDTFGWQKDEHGLNHFTFFIENGRIEDTPEFQMKTGLREIAKSLKGQSEFRLTGNQHLILSNVADEDLDDVKQLMKKYKLDNIQFSALRLSSSACVAFPTCGLAMAESERYLPVLISKLESCLEENGLRQDSIVMRMTGCPNGCARPWLAEVAFVGKAYGAYNMYLGGGYHGQRLNKLYRQSIKEDEILAIMKPLLKRYALERNEGERFGDFCVRSGIIVATTDGQNFHDNVAEEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0E6B5</accession>
    <name>S0E6B5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_06321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679028">
        <property type="protein sequence ID" value="CCT70356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023432435.1">
        <property type="nucleotide sequence ID" value="XM_023579633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E6B5"/>
    <dbReference type="GeneID" id="35399798"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_06321"/>
    <dbReference type="HOGENOM" id="CLU_1326419_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT70356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="200" mass="22646" checksum="B8714CC6F167BE83" modified="2013-09-18" version="1">MSSNPQAGVRITLYQAPSDPHDILRAKDEIIAKLTARITQLNADKEDLQAQIMQRDKETAILQNFTHEQAIGIRDLNSKIGRQGKQIKDLMYEQSVSYSTIDDKTHEIGELKAQVSKQERELQDQGREIEDLEAQIAIFQRVIDDDNISTSSNSSGTDYDLMDLSSNEEEEEQDIDPDNDISSTTDNNVLDNSSGRYRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0E841</accession>
    <name>S0E841_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433105.1">
        <property type="nucleotide sequence ID" value="XM_023580304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E841"/>
    <dbReference type="STRING" id="1279085.S0E841"/>
    <dbReference type="GeneID" id="35402413"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08939"/>
    <dbReference type="HOGENOM" id="CLU_049471_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="317" mass="35299" checksum="02E08E11898420FF" modified="2013-09-18" version="1">MESSSGLHPSFANNAVPSAPYVRRAPSPPFIHIPPTGQCGVSAAPILLPSYEHVDSSQLTTHDVKIITQNMQQIATDRAADWSYEQRRDAQKLVDFLYLGPNSTAKDIKRLQEEGITMIAVARDARMAGVKLMSVEKAAKTLNIEVQYIDLEGNDKLISSFPDIIRLINDHLLSVYHSQAKGRNKNGELLVDPSSFRRGKVLLTCETGNDRSAAIAAAYIMAVFGKDMITAVQFISIQRFCCAFDEDTKRKLQCWEDILRARSQVAMEQAVPPNAQHTKRHIDDMMDTSEDPNDKGEFALDQDRFNGRGSFAPFVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0E898</accession>
    <name>S0E898_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable negative regulator of cdc42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_07511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT68703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023430783.1">
        <property type="nucleotide sequence ID" value="XM_023577771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E898"/>
    <dbReference type="STRING" id="1279085.S0E898"/>
    <dbReference type="GeneID" id="35400988"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_07511"/>
    <dbReference type="HOGENOM" id="CLU_141247_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT68703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="129" mass="14368" checksum="C2B7856AA04A6DEB" modified="2013-09-18" version="1">MSSQPLLQTTPGKRIALPTRVEPKVFFANERTFLSWLNFTVILGALAIGMLNFGDRVAFISAFLFTGVAMLTMIYALVTYHWRAKSIRMKGQAGFDDRFGPTVLAIILLLAVIVNFVLRITDKSKNNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>S0E8C1</accession>
    <name>S0E8C1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Related to proliferation associated SNF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_08838</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433195.1">
        <property type="nucleotide sequence ID" value="XM_023580415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E8C1"/>
    <dbReference type="STRING" id="1279085.S0E8C1"/>
    <dbReference type="GeneID" id="35402314"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08838"/>
    <dbReference type="HOGENOM" id="CLU_000315_17_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001315">
        <property type="entry name" value="SNF2 family helicase/ATPase PasG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="150"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="638"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="426"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT71116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="871" mass="98583" checksum="21AEB73BF53BD5D7" modified="2013-09-18" version="1">MAAPKSPSNSSSARSNSRLPTSVPSSPPSEQQDDLEGADEALIKEEQEARLENERNEEKRRQAMLKRKKKKKAETKSEREAKARELDDLLAKSAAFSDILTKKTQVLGRVGSSLDGKTLGEHSLEMAQQPKCMINGTMRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIMYHGNKDDREKIFRNKMLKHLKGGRPTTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDFSDLEDEQGTEEFIADQKKQELVKKIHLILQPMLLRRIKQDVAAYLPKKREYVLFAPMTKEQTDLYNVLTNKKVDTRQYLEDKVHEKIYGPNSTEASAKSSRSSSVAAPKTMTLPVRESPRKKQVEPEEPVTNAFSVMMAKRGRGRPRKNPKLEEAPITPKSGGKRKGAPASLEPEPKSAKSTRQSTPVSTRGRPRKTRTYKDAGSDEEKMSDDEFEAKLADEMVSDDEDLSDQVSMTPEERKQAEAFDLAKKQIAQKKLGNPLAQLRLVCNSPHNFYNPWIASQDLPVDDSIVTASGKMLLLDRLLPRLFEDDHKVLIFSQFTTQLDILEDYCRELRGWKVCRIDGSVAQESRRTQIADFNSDPEYKIFLLSTRAGGQGINLASADTVILFDSDFNPQQDLQAQDRCHRIGQTRPVVVFRLATKDTVEETLLNSADAKRRLEKLVIKKGNFKSMGQKMDLHEDIDPESLRALLLKDGQVYKTSGDEQVLSDADLDVLCDRSETAYEKAASGQGDADAFRVVETGADSIKMARKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9A2</accession>
    <name>S0E9A2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to tocopherol O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_08469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433533.1">
        <property type="nucleotide sequence ID" value="XM_023580827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9A2"/>
    <dbReference type="STRING" id="1279085.S0E9A2"/>
    <dbReference type="GeneID" id="35401945"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08469"/>
    <dbReference type="HOGENOM" id="CLU_039068_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025774">
        <property type="entry name" value="PiNMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF11">
        <property type="entry name" value="GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51581">
        <property type="entry name" value="SAM_GTMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="94"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif I" evidence="4">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif III" evidence="4">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT71454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="376" mass="41614" checksum="23448BA6D1A10B59" modified="2013-09-18" version="1">MAATAVSDQTTDLSKQYDTPLGLAHSTMQVLKDRIKLHYDLASDYYLSLWGEHIHHGYWPTPESEATQTKEEAQTNLIQLLLDISKIPSKCSVLDVGCGIGGTSRYLASKHGSSVTGITISSKQVEIANRLTKTAIEDTSSSDASDDNGFTKFGEGNVKFLELDAEEMGDFFSNQQGTFDAVWISEALSHFPNKALFFENVIKVLKPGGKLVLADWFKDEDVDVTTFINDIKPIEDGMLLPPLCTQQGYVNLANKAGLKVLSEPKDISQQVRKTWDITWSLVQNPSLWAFAITQGRDGIAFLQSFRAMRRGYANGSFRYAVMGFYKEMDIASYLISGKFSICIHECRSGLWQAIQAHGVLALTVPSWRNQVMAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9I8</accession>
    <name>S0E9I8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to endosomal Vps protein complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_08371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433625.1">
        <property type="nucleotide sequence ID" value="XM_023580936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9I8"/>
    <dbReference type="STRING" id="1279085.S0E9I8"/>
    <dbReference type="GeneID" id="35401847"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08371"/>
    <dbReference type="HOGENOM" id="CLU_069208_0_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="228" mass="26018" checksum="69367F3AA1D1A08D" modified="2013-09-18" version="1">METFKSLFAKPDPQAQMRKCNALMRQNIRKIDRDIQTVKQVEYKTKNLILQADKRAQRDPSRAKQAQQEVRDFARELVRARKTSARLITSKAQLNSVQMQVQEAFAVRKIEGSIRASVGIMKDVNSLIRLPELAGTMQELSVELMKAGIIEEMVEDSLPADGDMLMEDEEADGEVDKVLGEILKDRKQPTLPVAPVPEPQKPQEEEEEEEDPEAMMDQMRNRLEALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9S7</accession>
    <name>S0E9S7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_14916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679027">
        <property type="protein sequence ID" value="CCT69238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023431318.1">
        <property type="nucleotide sequence ID" value="XM_023576915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9S7"/>
    <dbReference type="STRING" id="1279085.S0E9S7"/>
    <dbReference type="GeneID" id="35408282"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14916"/>
    <dbReference type="HOGENOM" id="CLU_069652_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="85"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT69238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="343" mass="38293" checksum="836DF82D738A6536" modified="2013-09-18" version="1">MTTEQSRVSIPTVTDGQEWPFPYRIYLNCVTWTLRKLVSFLTGPNEGHDREVKISTPGLGAGYVICNVWLPKPTDDIQSKYPLVLVLEGGGFVLGHPKDGRLNNRQIVDQTGAIVMSVDYAKAPRYPYPHALLQAYEALRWALTSSAACEGIHVDPSRVAIGGNSAGGNLTAALSLLLSFRSGPCSIFRERLPLDFKQVLHFMFYPSLELCLPYDLRLSRSTIDAQKYSLPAWMARAMEQSYLPPRVCKDDIFISPVAAGLDLLRELDIPPAVMFTGSLDCLKEEGFCYAQHLTKSGKEVTFHEFQGVTHGFSVKPQDGSMEAQVMYEECWSRICHCLRESFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0E9X4</accession>
    <name>S0E9X4_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_08225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433758.1">
        <property type="nucleotide sequence ID" value="XM_023581098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0E9X4"/>
    <dbReference type="STRING" id="1279085.S0E9X4"/>
    <dbReference type="GeneID" id="35401701"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08225"/>
    <dbReference type="HOGENOM" id="CLU_062065_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT71679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30251" checksum="A6FB02B4CE3A9373" modified="2013-09-18" version="1">MTSLKSRSELIDLLKTILNAPNETKWETLESLFQPSMLIDTTSQSREKFIANLRAASGVSVKLDSCVVDVNAQAVAGRVIKTETLPDGERHECQEIILTWFVDGRLVTLKRLKDVDSRSAKQTATPSTLEEQKPTSLDLAALYRDYIKSINDKTMEANFDKFCHPSVTHNTVKKTIAEYISLISESQSAIQGLYFDIQDLIVDNDAGRVAARLEFTGLSVKAWAGAEPNGKSVKFHEHVMYWLDEGKIHWVWSVVDLETYRKQLKQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAP4</accession>
    <name>S0EAP4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_14052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434032.1">
        <property type="nucleotide sequence ID" value="XM_023581318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAP4"/>
    <dbReference type="GeneID" id="35407506"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14052"/>
    <dbReference type="HOGENOM" id="CLU_158755_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004495778" evidence="1">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT71954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="111" mass="12519" checksum="7667B1659E002E08" modified="2013-09-18" version="1">MRFAITLLPFILPVLASDHKQCDCQINNGDGWKYDWQLTFNVCVDNYEKTAEYDNGAGRCIANPHTRLDGDRFYQNCKDLAKKGWYPVVNGAVDTTQAKIYAKQGGSGCYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>S0EAY2</accession>
    <name>S0EAY2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_13941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434139.1">
        <property type="nucleotide sequence ID" value="XM_023581441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EAY2"/>
    <dbReference type="STRING" id="1279085.S0EAY2"/>
    <dbReference type="GeneID" id="35407395"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13941"/>
    <dbReference type="HOGENOM" id="CLU_556724_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="445" mass="49224" checksum="FD94FF51C709AB81" modified="2013-09-18" version="1">MTNTDDKKKTQKDPNSKRKGKDDDKHLTNRAGAQSGQQNPSARGDETGSGLAIKHPAKPRRSATLPANVSALGSSVDKIGQTDMSFVKQNTGAPINNEMGITRGIPVDVPGFGQLSGPGEVLTTAFRGAQPSNFVQEGSKQKFVGITSTPESRLLDDSRKTILAQRSSVQQKNDAEAENGGQDQGYRPRKRQRRPFCVGCKSDQHYIDRCLKASDNGLMKGCPVCNTLEHSAEDCNSPRVLDDVDRTCEFVYRRRNMPSFLTFESWYDLVRDNASPAPTNMDRFPWTPEFTKSISAAIDDLQQKVNDLGLEDAKLPVDPSVNGWTAVKGHFNEKAPTATMDQSEEPELPFTMTEEAPAQVESQSGVAPVPEQEPVTAPTDEPSLFAVAKKQQENSRRRPWDEDSEVEDDEVDSDDDEANRRKMQRMRRAERSEMVLRASSHTPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBA3</accession>
    <name>S0EBA3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFUJ_14072</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT71935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434013.1">
        <property type="nucleotide sequence ID" value="XM_023581296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBA3"/>
    <dbReference type="STRING" id="1279085.S0EBA3"/>
    <dbReference type="GeneID" id="35407526"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_14072"/>
    <dbReference type="HOGENOM" id="CLU_022549_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="193"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCT71935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="468" mass="53992" checksum="6FA8B93A8B54D58B" modified="2013-09-18" version="1">MFTTYRDNRILPVFIIATCLVLYYSLLNSSVERFGARRLPVNSQSEPATQLVLEPSHQSQQTQPGGHGKLEGHDVLLILKTGGTSMYHRLLIHLVTSLSPERVNPENVVIYSDYEETMGNFTTIDVLKNMTEATKSHPDFDVYHAVPQYVKNNVYIEHANIEGDHEGPVGGWVIDKYKFLPIMDHAGKNWPHARWYVFMEDDAYIFLPNVLDYLSSFDWKAPHYLGSSAFIANVTFAHGGSGFALSRGAWEMSFGKNPRLVEDFAEYTRQHGCGDHILGRALNKYGIRFGENGGDEKFTWGFNAVVHWKFGFRSENWCKPLLSWHKAHSRDIARYYELEKNWNFKRPMLFKDFFKKIIAPDLGKRREWWDNMSSLFAITSANTNSPPAPQSKYNRSLWANAWKSVDACEAACKSWVECMQWSYYDDLCRMDDKLIMGSGFAPGMFQRKTRLLITSGWLLHRIKNWECN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBM3</accession>
    <name>S0EBM3_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_13980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434103.1">
        <property type="nucleotide sequence ID" value="XM_023581398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBM3"/>
    <dbReference type="STRING" id="1279085.S0EBM3"/>
    <dbReference type="GeneID" id="35407434"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13980"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_4_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT72025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="325" mass="36101" checksum="8444A46595D9E2E9" modified="2013-09-18" version="1">MTTQDSETIDTTASSSIWGDFVDSDGECDVEDACEPVDRYEEGLYLPICIGEVVADRYRIEHKLGHGGFSTVWMAHDMDQGKDVALKIMTANFEDLNSANVMFGLSSFEPGADISTKYQILGRPQKMELPTGPEMWKKGQLVAPTSPKDSFVVQDTITLGDFGLTIRSGTEVDFKLQGTIGYCAPELMHGINPTFASDMWSYTCIFAELYLKWPLFGPGFFGGGLRFIVGLLIRVLGPMPLSWKGLYEGGGEPEDSWYDQSRVPEPVMSLESRVTKSRDTLEPAEQQLVLSILRRGFSYLPEERLSAGELLEDASFKALMEMYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EBY6</accession>
    <name>S0EBY6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase I-specific transcription initiation factor rrn11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434482.1">
        <property type="nucleotide sequence ID" value="XM_023581856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EBY6"/>
    <dbReference type="STRING" id="1279085.S0EBY6"/>
    <dbReference type="GeneID" id="35405727"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12271"/>
    <dbReference type="HOGENOM" id="CLU_027162_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45422" checksum="68B2596C6EB4B803" modified="2013-09-18" version="1">MDSLLDPPSFSQQSRSNKRKRSETTDVDSPSSKPQSSINPLSHSPGVVAQFAVAGLSETDENPSQRIRDFPHRGSSSNEAFSIEAESDEDPETEGDEAARPKSKKSKSRKRGGHFDVLLQSIHYFLDRGEIRKASRAYGLILQLRPSGLLVDVRHHDLWAMGAEILMREGEDTSRQDDGSHENQLKSTKRWGRAANMSKVKAYFDTLIQQHPYDYKTPKVVSALDFWIALFSCEIYNTHTEHILAIDRLESEIDEESRRESFGNDESIASDETDSVEARKLLKKDELRVQALSIMKDITKRMDVLMQDMPYSRNQHYLRLHAMASFYIADLVIPISPVSQYQAEEAQKARLAEQQSARNHLERIITYGGELDKAAWKALNPSGDVEGDTSIPLYSSLPIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDP6</accession>
    <name>S0EDP6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434853.1">
        <property type="nucleotide sequence ID" value="XM_023582300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EDP6"/>
    <dbReference type="STRING" id="1279085.S0EDP6"/>
    <dbReference type="GeneID" id="35406123"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12667"/>
    <dbReference type="HOGENOM" id="CLU_060131_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="231" mass="26324" checksum="2B424881C6F95739" modified="2013-09-18" version="1">MSESSDPAPKYRIRPGTFFDVPATTRIYAASFSNEPLIDFFFPTRRQDPLSFFTWSCRRFQRRYWTPGYSLSVVVDKHDHPVGLSWWKRPTQPLTLLQKLLSPSFWIGSVVNAFIDLQEYLFPVQGLNKKNMETFEQAFSAVEPHVLDTPTRQKAHYLSLLGVDPVLQGEGLGKMLLEDGLEKVDDADSAAWLVSLAGLEKLYARYGFAEATKVEVEGLHDWKGGMVMVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EDR8</accession>
    <name>S0EDR8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_12698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="component" value="Chromosome VIII"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="MEMBRANE PROTEIN WSC4, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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            <begin position="1"/>
            <end position="19"/>
        </location>
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            <end position="272"/>
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        </location>
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            <end position="394"/>
        </location>
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            <end position="218"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT72805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="394" mass="40923" checksum="1EF8A8E1814F75DA" modified="2013-09-18" version="1">MRSTSQALLLGALLQATNAMEMAHAAQRNRVRDAAPAITEAPYGLVHEAELLVGHNGLHARQAAASSSEPLVVTIAPDATCGYLSGQAGAAVTCGNGRPCSWAATSRTGLVGCGNDIYILCVESSVAVNPSSCDDVCQSNTFYLKCTDSDTPFCRTYAYPSGIADYRCASTSVEKAQSVEFTYDGQKNANFKTTTLSDGIASQSLSATNTDSGSGSAGQASETETQAETTTTSEAPEPTKKSKSTPVGAIVGGVVGGVALIGLIGLGVFCLLRRRKSKPEPAPAPAPAQPVMAQQQAPPPAPMNQNPYPQQQYFQPGVQPYPDHSMAASPAPSDARISMMSGPISSVGPTSPGGWHQQPSPPPFHTPAPAYEMAGPEAREQEPVYEMGSDSVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EET4</accession>
    <name>S0EET4_GIBF5</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_10133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
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        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
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            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="111"/>
        </location>
    </feature>
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        <location>
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            <end position="195"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="351"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="528"/>
        </location>
    </feature>
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        <location>
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            <end position="266"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="556" mass="61576" checksum="FFA10C25B83EA168" modified="2013-09-18" version="1">MADQIEAIPGTVHLVDAQGSMDSQHAKGAEHDIVLVPAPSAHPDDPLNWSPRRKYLSAYVLVIGICSSALYSTLGPLSESTGLSYSDLNSGTGYMFLFFGWGCIIWQAIAIQYGKRPVYLLTTLGTLGVMVWQPHVRSNGEWIATKILQGIFGAPIESLAEITVSDVFFTHERGKFIALYALALGYSNGIAPLIMGFINDGQGYQWVFYWCAIFCAVLLLIIFFFMEETKFDRAKYMTSNHIEGRTLSSANQTSTDPDTKDDLDTKHDAEQDQVATTTLTNVSAPNEAFDHDSTEFSKKSRISRLKPIERKNLRGENRLIKLISRPILLLAFPIISYAGFIYGCNIVWLSVLNATESMVLSNKPYNMPTSTVGLTFIAPLIGTTLACIYTGIFGDKFIIKMARRNGGFMEAEHRLWLFLPSLVLIPFGCILFGVGAYYEAHWFSIVFAMGVISFTTTAGSQISIAYCIDCYRDLASEALATAIIIRNTMAFGIGYGVTPWVVNLGYQNAFILGAFAGLAHNLTIFPVMKWGRALRQRSAEKYWNTVKEGADLDLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFA2</accession>
    <name>S0EFA2_GIBF5</name>
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        <submittedName>
            <fullName evidence="4">Related to integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_09928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
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                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
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            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023568115.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="35403395"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09928"/>
    <dbReference type="HOGENOM" id="CLU_045148_0_0_1"/>
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        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="11"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
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        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT73385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="337" mass="38051" checksum="E6A0854F6869EE8F" modified="2013-09-18" version="1">MAAESGETGQTGPISVSLPVNMAIAGLFAIACYNCLEILISLLSRFKRHDGLYFWSMMVATLGILLHSIVVMLRYYSLGPNFLLCVLTCVGWYGMVTGQSVVLYSRLHLIVEDKSKTRWVLYMIVINFFILHVPTTVLFLGSNTKHSARYIGAFNVYERIQLAGFCIQETIISGLYIWETSRGLKPIFAVRKKMERKIMRYLIIVNILVILLDISLIVTQYMSHFNIQTTYKPVVYSIKLKMEFVVLNKLLLLVQHSDCNCMHIVGEPETPPPDPSSVECQSIGRNSSTRTGSDVPIQMNVAPIQMNHFQKYNTNASSQSGGRHQKASPLNFLDYCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EFI8</accession>
    <name>S0EFI8_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_08814</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679029">
        <property type="protein sequence ID" value="CCT71138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023433217.1">
        <property type="nucleotide sequence ID" value="XM_023580442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EFI8"/>
    <dbReference type="STRING" id="1279085.S0EFI8"/>
    <dbReference type="GeneID" id="35402290"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_08814"/>
    <dbReference type="HOGENOM" id="CLU_086812_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT71138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="177" mass="19880" checksum="F9A5AD6B510C202E" modified="2013-09-18" version="1">MAQKAARDWVYLVIISLQLIGMICLEFTEFYPEAIYSAPNAPLRFLANVKEQYLSFSGDPFFGDKFHGAWFRSMFFIEIFVQFPLAIYIVRNLAAKKPSSGPVELAGLAYGCLTAMSSVACVAELLEMGPGLVSEDHKRNLVWGTYFPYALIPGAMAVDMYTRLLRRVSTDIKPKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGG7</accession>
    <name>S0EGG7_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to nicotinamide mononucleotide permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_09289</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435962.1">
        <property type="nucleotide sequence ID" value="XM_023568825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGG7"/>
    <dbReference type="GeneID" id="35402758"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09289"/>
    <dbReference type="HOGENOM" id="CLU_001265_2_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT73884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="545" mass="62400" checksum="539A9BC5DDF19EDD" modified="2013-09-18" version="1">MATVLVRDQKYLDVSESEISVDSVPPLGAPASVFDDPKTAEQYQPRSDWENLSRFDPLARWTWGEEKQLVRKVDIKIMIWACTMFMALELDRANISQALTDNLLGDLGLTTNVIGYNATDFNLGNTVFKLSFLCAELPSQLVSKWMGPDRWIPTQMCLWSIVAAAQFWLSGRESFLACRAFLGILQGGFIPDVILYLSYFYKHHELSIRLGFFWTMMSVADIISALLAAALLEMRGINDHAGWRWLFLIEGLITLIFGLLAYGLMPPGPIQTANWFRGKTGWFTEREEVIMVNRIIREDPTKSTMHNRQPITFKLLFQSLSDYDLWPLYLLGLTFQIPATPEGQYLTLSLKSLGFNTLQSNLLSIPYTVFHIITMLILTYAAEYVKNLTLMGIIGQIWILPCLIWFNVANTQTASRWTVYAVTTVLLSYPNAHPIQVAWNSRNSNSVRSRTVSAACYNMFCQAGGIIASNIYRKDDAPKYHRGNRQLLAILIMNIVLYVLVKAYYILRNKSRDKKWNDMTESERLKYLDTTKDEGNRRLDFRFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EGM6</accession>
    <name>S0EGM6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_12875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435055.1">
        <property type="nucleotide sequence ID" value="XM_023582532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EGM6"/>
    <dbReference type="GeneID" id="35406331"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12875"/>
    <dbReference type="HOGENOM" id="CLU_2097074_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT72977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="116" mass="13119" checksum="67C8BF667AD0AE35" modified="2013-09-18" version="1">MPPKAPKAPKGGETLASILIGGTLYAVAVTGMASLFEQAGDKKDSKEDSKQAEPNWLQRNFPAKEKGYYMKQVEEEFRDHHEKLKIERQQSPPTYDTSLLKLTEQDRLQAENMLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EHZ6</accession>
    <name>S0EHZ6_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MACPF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436358.1">
        <property type="nucleotide sequence ID" value="XM_023569096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EHZ6"/>
    <dbReference type="STRING" id="1279085.S0EHZ6"/>
    <dbReference type="GeneID" id="35403791"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10326"/>
    <dbReference type="HOGENOM" id="CLU_010317_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054586">
        <property type="entry name" value="MACPF_1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22693">
        <property type="entry name" value="MACPF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MACPF-like" evidence="2">
        <location>
            <begin position="434"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="1037" mass="113544" checksum="B83921E6A4D62FE7" modified="2013-09-18" version="1">MSAEPPKPTKEDVFVKVYSLTTSPKQGQDGDASVAIGRMAVTTLKFADDASTFQTRITLAEIRTKINEALSSEQTFKFCADDCSLVPEDVTLETYKQMMRSSAMREAKIPTVLIAPTSEPASSQSAALQDSFIMKFIQVGDKPEDAKNVGSLHASAFKGKDPSTMILGELRRLIGKMSADPKMHTFCSLDGTAAGDELTLQKYLALDNAKVHPSDGTPAIIIRYRSSDAKVSAAASKFHGASQDVLQAMEQMKPDLSFKDRSAEEMHVDTTAINVQETLRSSDIAAREASPLKYTSQMDEADWDSVLRNCSLLYGWKVDKRTSRIVRATTPAFRLRNKLPPRPIAFPPAAIQQPVISPETSTETPVASTAGTEKSPDSPKDVSVEGQGTEATVKPEKPTSTEKAEAAIETQKPLTAEDVEAPIPAKLGAIPSYAINDRSRIEITMVSNEFQESMARNHFSASSVEASASGGWSGYSVGVTGGAAQENTSGGTKTKKGYAKRMIGSYMFPRVDVFLRPEDLEPTEELRTALDGIKQTKNINALRELYSTFGHLFCHSVTLGGCLQTTKVVESDEDVQQSKDKESFKAQVGVAVSTPFGAKGNVKGSKESQDSAEGYNRIAKANENMGFEATGGNSILAADPPAWSGSVANFNNWRIIEQTELTPIIDAISKMAGYRETRSWFFAAVPKLSEYMVIPESRMLHVRFKVASQNESFGVISQKKIPAYLGHRPNESVTPVRTNLRVPDRQPKEAFKNGPFGLIGDMAKITAQNPGSSTTPLFEPSRTQTPILLFPSGAELGTKTDKAFSHVVWRLEIARGHSIGPDTLLCIKTAAMRKADLALTVYRNAQGVFLPSISSTDEPCYWRLEPVETSGISRLKGDRYKFGESFRLTWSFSDQTSGFRDFVDDSYGRRNLNRPAEMKSDKLCFKVPFPRFESMSSDYIALLMSTALTTDPIIDKIKVLDGFNQEKPYNFHDLTFRVDLVGNDGNGDKDDYANLATTSWQELDQKLSPGEKLLGNMLGPSPTVIDGVLGGMEFTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI43</accession>
    <name>S0EI43_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">FFUJ_09691</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435585.1">
        <property type="nucleotide sequence ID" value="XM_023568378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI43"/>
    <dbReference type="STRING" id="1279085.S0EI43"/>
    <dbReference type="GeneID" id="35403159"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09691"/>
    <dbReference type="HOGENOM" id="CLU_023471_1_1_1"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCT73507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="455" mass="51506" checksum="3BDC19628116F62E" modified="2013-09-18" version="1">MARPKRGVRFPNRNGSDGRRSSFSSEDGGSPTKLKSQSSGQLETVDEKQPAVSEKQAEYEKKKANFITRTFWTFVMFALFFAALFMGHIYIICIITAVQIVSFKEVIAIANVPSRARSLRSTKSLNWYWLATTMYFLYGETVIYYFKHIILVDKVLLPLATHHRFISFILYVFGFVFFVTSLQAGHYKFQFTNFAWTHMALYLIVVQAHFIMNNVFEGMIWFFLPAALVITNDIFAYICGILFGRTQLIKLSPKKTVEGFVGAWIMTIIFAMLLSSIMMRSKYFICPVNDLGANIFTGLKCDPNPVFLPKTYELPELFFLPDTANFSVTIAPMQIHALNLATFASLIAPFGGFFASGLKRTFKIKDFGDSIPGHGGITDRMDCQFIMGFFAYMYFHTFIAIHKVSLGSVLETAITSLNPDEQLELVKGMGHYLRNQGILAEDAVACIDKLLPVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0EI65</accession>
    <name>S0EI65_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434126.1">
        <property type="nucleotide sequence ID" value="XM_023581424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EI65"/>
    <dbReference type="STRING" id="1279085.S0EI65"/>
    <dbReference type="GeneID" id="35407410"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13956"/>
    <dbReference type="HOGENOM" id="CLU_657294_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="238"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="418" mass="46770" checksum="ECEA9443FA4F2905" modified="2013-09-18" version="1">MASINAPPMDFTNASYTNLPSTASIRLLSFIKRPRQLSPPSILGEPLLEITLETVDINEAPDFDLISSTWGNPDSADPGDIDEYGPMHLYPVTINGKLMFLPKNTYEALKMAQKVNDPVERRNELFLETELMTAVENNLGPKVQQLLEQGAHIHAQDCFGKTAIHHAAQLGHFDIINLLLDYGASMKVIDSYGKTPMDYITYTKPKDWENVEDIAYKMQKTPAERELVPLPEIIRVGRPMWIDAICIDQSNSEEQLNHASSIAQIYCRANSVIAWVGVQNEETKRAPDAILSILRADGKDPDEIMSDESASTTNPGCSYIPSSEEKSSIVRFLRRSWFEREDLMHEVAFGRAITVYCGMDALPFSSIMQFLRREAYSGTYLPSDLQVWSLLGSSGSKKRSSLGSRSTRKKVRRDSIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIN1</accession>
    <name>S0EIN1_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CPAF-like PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_13753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434316.1">
        <property type="nucleotide sequence ID" value="XM_023581651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIN1"/>
    <dbReference type="STRING" id="1279085.S0EIN1"/>
    <dbReference type="GeneID" id="35407207"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_13753"/>
    <dbReference type="HOGENOM" id="CLU_014251_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012226702" description="CPAF-like PDZ domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="3">
        <location>
            <begin position="172"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT72238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="737" mass="80361" checksum="1F90B84EE7838E3F" modified="2013-09-18" version="1">MIPSILLALAGVSFAALEPRQVMHQARNQPSFISSRDLSEAESEPCKFISQAYVEAEPEPGKPVILAIPPSVGIACLKSVPLDKKRDLELLDYLEPLIGFQSTLEILADPPKEYLFPGVDVLGGFDTIRSKLENNKYKTQYEVMTDLRSLFAAANDGHFDYPPALLNAFYYVRRGVEFESVSANGLRLPYIFHVIDTSRGNQGLLDYNPSAVKSIDGTPIAEWLEEDASFATSNSQDPDAQYNGLFASIPRSAVGSSSSTLFTQFEIPDTYTIEFHNGSTLEIVNQLVVPATVDLSGIESGEDFHYYVEITPTNTTTEEPSANERRSTQETDDDLPGYPKPLVKQSSNAVSAYLLNGEDYKDTAVLSILSFLPIGIDISNPPADFSMTKFILEGQAVILQLIKAAKATGRDKLIIDMSANGGGSVILAHSIYRLLFPEGEFTGWDRYRANPALEAASEVDYDNLVKSLITRSEYYPVAPGHKYLETGKEFYGPYTVKGQNVTAAFQTDKTVPWDESIPAYINGFDPERKPLVAEAPWKPENIIIVTDGICASACGILTGLLTRNHGIRTLALGGRPLNQAMQAMGGVKGTLLNFNADITSAIANVRANAKTDKETAAILSDASSSFPSSQNPPLLPLPAGGVGKVNSLNGYTEDNLEGYPVHFRYEAANCRLFYTQRMMASPIESWRRARGVAWNNEPCVSGSTTNSDGTIGDKTLTYDSRVRSRASGIKGPGELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0EIW2</accession>
    <name>S0EIW2_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to sensor protein hoxX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436623.1">
        <property type="nucleotide sequence ID" value="XM_023569402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EIW2"/>
    <dbReference type="GeneID" id="35404064"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10600"/>
    <dbReference type="HOGENOM" id="CLU_008537_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08650">
        <property type="entry name" value="FMT_core_HypX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047180">
        <property type="entry name" value="HoxX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388:SF1">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="2">
        <location>
            <begin position="274"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="757" mass="83670" checksum="AE78C185F972E4B3" modified="2013-09-18" version="1">MGSLKLSRGTSETSRSSDSGERRLPTTPPMKILFLCTAHNSLSQQLYLILSQKHDVTIEFALSDKAMIEAATLFQPNVIVCPFMTTRVPSEIFSKYLTLIIHPGPPGDAGPSALDWVLMGDDGNVIDSDQLLKSQSWSQNSRSHWGVTVLQAVEEMDAGPVWAFEQFKIDIDAPGVSKSTLYRKEVTQAAIIATATALHRIVSAANGFSDSGIAAALSRLSLLDKQDIHGISVDLVPNRNYKSLSVTLRKPFLGGPTHRRPLLKAADRNFDIQYEPARTISRKIRSADSQPGCLTKLFGGVGLYVYGGTIEAGRDAKCKRGPGQIIGCRDEAVCVATCDGHGIWITHIRRVKRKADPMLWPKVPAVSGLLDLGLINQSTLNSSLSLRPLFEWSKATYSTHQEIWVEFAASAGKRQVAFVYFEFYNGAMSTSQCSRLIEALEFVALHEALDAVVLMGGDSYFSNGIALNVIEASDDPAAESWKNINRIDDVVHMLLDVFPRKNVTTIAALRGNCAAGGVALAAACDVVIAGSEVVLNPAYRTLGLYGSEYHSLSYVGRCGPERAKYILRAMLPMSASQARDMGLVDKVLPASGHFLDMRIRHHIKELSFTTYKPGKWKSKVDVSHTGLTAAKTLELGEMAKDFWSARSERYNTRRRGFVRKVKPTQTPLRFATHRRRDGDLDEEESDYFDDVAVFEKLVIERISKERLSKMDARLLSLHEELRSHDHPSSKGGETRRPQEGKGLMFPCYYEVDTHVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ33</accession>
    <name>S0EJ33_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023435960.1">
        <property type="nucleotide sequence ID" value="XM_023568823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ33"/>
    <dbReference type="STRING" id="1279085.S0EJ33"/>
    <dbReference type="GeneID" id="35402760"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09291"/>
    <dbReference type="HOGENOM" id="CLU_039760_1_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="45"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT73882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="374" mass="42910" checksum="B01DF9278420C53C" modified="2013-09-18" version="1">MKRRFMTWYVAKREKHNGVPEPPTLPSPRPHILTPSPSIEALSQSQQDAPFFQMLPYEIRRQALIEAFGDRTIHMDLTYNYPPMPGNEQTHAMIQEWWSGLDKSRPKSWSWRGCICHRRPPPWHPAIATESYSSRAVDKDRCCVGIAHCCDMWKKNGEELYGCWIGALVSLQTCRQAYTEGINVLYSTNTIHISSAILLTDLPEYILPQRLSAITSLEIIWSVETDVCKGKNLPRENDLKAILLILDNHFPSLKKLNLALKLGLSKDRKTEFRHIFAILDDFFNRHTSDRMQDPFAVSISYAAYVELRREIIRAQGHKGDTFHWQIWRSFDGEYVLPQKPWTGAYLEAIPGARCNNGYWIYSGEITTPTGGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJ85</accession>
    <name>S0EJ85_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Related to epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFUJ_09236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT73932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436010.1">
        <property type="nucleotide sequence ID" value="XM_023568885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJ85"/>
    <dbReference type="STRING" id="1279085.S0EJ85"/>
    <dbReference type="GeneID" id="35402705"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09236"/>
    <dbReference type="HOGENOM" id="CLU_019414_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004485691" evidence="5">
        <location>
            <begin position="20"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCT73932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="406" mass="45765" checksum="8CE55A13685725EE" modified="2013-09-18" version="1">MRPFLSIPFLTSPLFLVTASPVSRDGKDSSFNLKPFTVDLSDGVPHMIDLAERTRLPTEGDYFDPNAGISLETLQSLRKELIENFDWNAEQQELNKLHHFTAEIENQTIHFIHQQSDNPEAIPLVLNHGWPGSFLEFIPLIEKLRDDFHIIIPSLPGFAFSSAPPPTWTVDDTARLFNTLMTKVLGYPKYAAYGTDWGSGVAYSLYANFNTSVRLVHLSFLPFVPLYRTQLAAEGIKLSPLEEFEAQVAEEWATTGNAYYMEQATKPNTIGLALYDNPVGQLSWIAEKLIVWSDPRTGTPPSVLDHNEMLKTVALYYLTKSFASSVYIYYSNPNGFMTNYTKAETDAPLLFSAFKYNPGFWPPELVGRVGNLVSYKNHEFGGHFSGLDNPVALAEDLKDIKKYWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJB5</accession>
    <name>S0EJB5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitin synthase</fullName>
            <ecNumber evidence="4">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_10794</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="4"/>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436808.1">
        <property type="nucleotide sequence ID" value="XM_023569617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJB5"/>
    <dbReference type="STRING" id="1279085.S0EJB5"/>
    <dbReference type="GeneID" id="35404258"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10794"/>
    <dbReference type="HOGENOM" id="CLU_327890_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF8">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YORKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="489"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="365"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT74730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="878" mass="97609" checksum="8FD5059781AEEAA2" modified="2013-09-18" version="1">MSDPITASIQIGISAVKAGASIATWWELRQRNKREEGQGSTSSGRGAGLDEIYLVFASLGQRLMALDVVNYDALPEALAAVKVAMDISEDDLTYELERLDPILQYLIACGFMFCAACHPMPIYYGYGCGVMNDTNWSNPENPTYWNLDIDQAIAYLKSVPHPFQLLKKSPSRIGHSVPYYEKYDKKALKADAAAVTDVLKQIEKVGYPQPLPPNDKIRINTWSMPFATYGGSVMYANVGHDTSLLLTWQLDPGRFLYAWTVGERADLRPGEAVLLQDEHIGALASWLEGLNGITFKVLLDSDLDWSKLKLKSSTKKYYIAQSGDEYNITGIPDIIVRNPDPTALLAARLDTLHMISVSVPFTKAKEQATTSQAPSSPTPSSPQPPRVFSSPPTSPQSESTISPWSMPEKAAQTQFHQEPDVQPTLPWVDSTPMTPTSPHVSIPHNATSDPLTPLPKGWESRLTPDGQIYYVNHSDQTTSWTKPVIPTLAPLPPGWQEMHTPDGIPYYADHNTQTTSWERPPPAESTLPTYQSIGARKSVSLSTTSTTSSMPFSDKRSSVSMQSEATTIVSNSQQSRVKLNNYSNPYPQRPRQLLNPYLYPAKGKTACWVSDVPVTPDIYQKLPSDQYETSYIRHTALAGQPTDLQKLEYSLRQRGRTELVIGLNLHNESTFKREVINGQLIKSLGSILEVLRTHSFCQEFNQRCKGSPLSGIVVCILIHQDRMKDIPWLRQTGISFMWDIPSSVPLTDSKKADGQFYDDAHKATRKILGKEVKLNLNEYTTTFHLQDWERSHGLMPDVVSGADPVHVVLCSTYRSWTGSYAADSFKHVCNLLDARLCISVPGGATVTGGSLEKQWQLSQYRKKPAESGQDAHCEEYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJC3</accession>
    <name>S0EJC3_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to RTM1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_10806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436818.1">
        <property type="nucleotide sequence ID" value="XM_023569631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJC3"/>
    <dbReference type="STRING" id="1279085.S0EJC3"/>
    <dbReference type="GeneID" id="35404270"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10806"/>
    <dbReference type="HOGENOM" id="CLU_033465_3_2_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF28">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT74740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="305" mass="33850" checksum="FA08982CBA70C87D" modified="2013-09-18" version="1">MDAPKSYYLYNPSEPLAGVVAGLYGVSFCITLWQIIRKKALVWLFMLLAIAMEVIGYAARAVSATKPTEKGPYVLQFTLVILPPVLMAGVIYVIFARIVFWVVPPESRTLRFLWVPARFITLLFVGFDIISLLLQLVAAVLIAGTDPTDPDAKNKLNLGKTLGLVGVSTQIAGFGLFTVSAIRFHFAARRLSPDFAKDNQEKHGIVKKWQTLLIVVNVSCLLILVRSIYREIDFAGGKDGTTHQKEWYLYVFDTLPILLVVFLYNVFFPGSYLKHLGFKVPKENQGAVLDSEAASKQVSTTAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJN8</accession>
    <name>S0EJN8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_12468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434666.1">
        <property type="nucleotide sequence ID" value="XM_023582078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJN8"/>
    <dbReference type="GeneID" id="35405924"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12468"/>
    <dbReference type="HOGENOM" id="CLU_099113_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT72588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="216" mass="25181" checksum="6D41F263DC9ABC14" modified="2013-09-18" version="1">MKHWGLWATDTKPPAGHLFHATDAGRQALDLYYEARKVRDPSKSKTMVVCLKIVEAPTVEYLNHYASQVPLMDPSYLPAGEVQWTCRVWVKETLKRLHQNSQIVLPAHVDTIESYGKYTADRYLSYMGNPPIINDLSWLTKAPETDSRNTRQAYYGTEPMQTEVYRQNPHQYQPRYYGAKPMQTEVYQHSSTQHQPRSYGTKPMQTETYQQGYSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S0EJT0</accession>
    <name>S0EJT0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DAN4-Cell wall mannoprotein, expressed under anaerobic conditions, completely repressed during aerobic growth</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_11308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437339.1">
        <property type="nucleotide sequence ID" value="XM_023570191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EJT0"/>
    <dbReference type="GeneID" id="35404770"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11308"/>
    <dbReference type="HOGENOM" id="CLU_994167_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496051" evidence="2">
        <location>
            <begin position="21"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT75292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="280" mass="28298" checksum="EB75ED5A583F90EE" modified="2013-09-18" version="1">MIAAKVLTAVAALILQPALAGPCRPISRSTTASAESSTLLTSTSTLTSLPSTTGLTSISILSLSSSRTLAGESTTTDASESETVTKETSVTKTSSESAASASLVTTEDSSSIISSATTTSGLYTTESTSQTLTVGLTTTEDISTTTETSSTDTISSEASTSATVTSITTTDRSSLSEASDTQTAGTEFHDTRTDTATTTDVSSTAGASSTSAEVSTTAESTTTYASTSATSTLEGFTITPSFTTLTTVATTAITTSTYTTTTEAASTTSEECQIYPYMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK60</accession>
    <name>S0EK60_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Related to quinate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_11208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437247.1">
        <property type="nucleotide sequence ID" value="XM_023570080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK60"/>
    <dbReference type="GeneID" id="35404671"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11208"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT75169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="547" mass="59959" checksum="08610EB7F3EDA2C6" modified="2013-09-18" version="1">MHPARYFSDSSLGKHIRSIRNSPREVIYNSQLLVSSALYAMSGLCITWDQGSSSVVPSLPGFSKAFGITSAANPSEVANFISFVYLTAGVGSALSFFINDRIGRLWSLRLYFAIWIIGQLIATFSYGNKGALYTARFVSGLGIGPLTVTGPMSIVEIAPTEIRGLLTVWFSVVMLLSLTISTLTVYACFLHLPASHLQYQFVWFLPTIICGIIIAASFFACESPRWLMLVGRKEEAIETLVALRGLPADHPRVAGEIADIEQQIQAEKSRYASGGGVRDILRETFMVPGNLRRVQQSLISYLLAQLSGANSVTSYLVPILSLMGINSAHGNNLFLSSMYSLSKFFYTLIASFFFIDALGRRKSLFIGITIQLISDVYLGAYIKSHQDGSVAPGASTAAIAAIFIHGFGYAVGLLVLPYVFGAELWPNSIRSFGSALSQTFHWLFYFGINRATPSILSSMHNWGAFIFFAGWCLVAVIYVFFAVPETAGLPLEHIDALFECPWWQIRSKAKTLHVTTISGSVVDEENSPESLDSKYDKIATTSKQTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0EK95</accession>
    <name>S0EK95_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Related to n-alkane-inducible cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">FFUJ_12716</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679030">
        <property type="protein sequence ID" value="CCT72823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023434901.1">
        <property type="nucleotide sequence ID" value="XM_023582355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EK95"/>
    <dbReference type="STRING" id="1279085.S0EK95"/>
    <dbReference type="GeneID" id="35406172"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_12716"/>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCT72823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="388" mass="44502" checksum="8351E2B4B38738F8" modified="2013-09-18" version="1">MFGVKWIYTYDPEVLKAVYATHFKEFGVTPIGNLRRGLTPFADKGALLMFIKLLPENGETVDLQPLLQRWFLDIATEFIFGESTEALVYPERAKIANTMLDVLDGGRLRAQLNRLMFLRDWTPWLKSVEEIHAFVTPPIQETIKEKHEREKKIKEGATNLEPERTDLLWTMVQNLEDVEELRSQICLILVANIDTTSVFISNCVWWLARYPDVWDKIRQEVHELGDIPMNFSVLRNMKYLNCVMNETNGKAHRMIPNNVSQLRGAFEDVVIPVGGGPDGKSPTLIRKGDLVLINKTVMYRDPEAWGEDSNEFKPERFDGYRGSWGFLPFGGGPRRCPAQMMVQTEAAYILAHLAKTFKRIEPRDPEPYVPVMRIGPSNKTGVKVALYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>S0EKW7</accession>
    <name>S0EKW7_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_11302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437333.1">
        <property type="nucleotide sequence ID" value="XM_023570184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EKW7"/>
    <dbReference type="STRING" id="1279085.S0EKW7"/>
    <dbReference type="GeneID" id="35404764"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11302"/>
    <dbReference type="HOGENOM" id="CLU_033555_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT75285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="74051" checksum="A7E2026997AD0D35" modified="2013-09-18" version="1">MSPGRTVSFIHTFADLLVRSADLSSQPQVSAMARTVLPLILTTTNSILRKASCEMEEPRIISGLKRVAWPELRRLPLITSSDRLPAGIKQVGLDIKREANSIIKRHGLQFKDEEDRCDPQMEMRGVPGKSGTSLPTILIFAPWSTEKQRDWERAAQEMAMFLAGLSRVCSFGETDIHVEIMAPELVQPTHCTNIDDPVYQSAWEYLSSTIFNRLQWLRATQGHVTCLSLQKYGTDDCVQDNPPTVYISVDNDSDETQWPEVVTEVKRTLDAAEWDDFQVHIEHNQGMVGYFDNLTKPTREQRHRAYRLKKRMESDYYSTVHIGDDFGAACDIKRTDGKQLSPTNGTIGCFVQLRTSGPEPTWRTFILTSYQAVRPAFDGFTVAPDGADTSVAPPTANSDLWTVDSVGYTPDSNYLEKTDWPQKEKQLQEFRQRIAALRDERKQKTEFFEANKKVLGSLYAASGFRRRVVGRRMDWALIELNRPWHDRLPEYEDWKPSFWRISAMPFMTFGMQLEEQTRSIEVLSDLEWSNDTFDVYKIRASSGPKAGSLLCTNNLVTIRDDQYMNPSPTEEMAFETHRYDYPHEHGFCAPGDSGSVVFDEEGGIVGLMIGGHKNNNSDNHGYGYVTPIEYVFKDIKDLLKGHVVDIRIAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0EL66</accession>
    <name>S0EL66_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_11396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679033">
        <property type="protein sequence ID" value="CCT75377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437423.1">
        <property type="nucleotide sequence ID" value="XM_023570289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EL66"/>
    <dbReference type="GeneID" id="35404858"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11396"/>
    <dbReference type="HOGENOM" id="CLU_585313_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT75377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="447" mass="51523" checksum="174DCAB5A82FAD3C" modified="2013-09-18" version="1">MANLDTLPVELVTKVVSHLSPQDVKALSCTSWLMRHAVVGVLFQTLIIPFPLASTQALEELIHKYQDFISTVHLHVSFQPNIEEKPHDGPMPSIWGVAPTDTLKKITQGDILRNVSSFVLEFNGAQFKDPGWWGEPAPWSDPNLPGSIFENGENWDQILQQERDFIWRAQYNEFMRAISMNLNITNLKIENLIPRNVSAWETPEWASFLGRLQVLEIGVFSGDDDLLHTNLGFIEFIRSLPQFLMRHARNVRRLTLEASPDALFGGASANYCIRLPLREDHLPFLRSLTLKNIMIGPDLVEFLTSRVDCFEELELHDCMCDEPEPEYGPDWDLEPVAWADLWRAMRESNMRLFKVSVVQSKTPPLLWQEGSSEEDGTSEESVSAARIRKMLEEDRSLVVWRYARVDYKYGWIVDLSDDNVKYFEEGEDQREYVKLLEVLEQRSKQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0EMH2</accession>
    <name>S0EMH2_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFUJ_11171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT75087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023437165.1">
        <property type="nucleotide sequence ID" value="XM_023570039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EMH2"/>
    <dbReference type="STRING" id="1279085.S0EMH2"/>
    <dbReference type="GeneID" id="35404635"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_11171"/>
    <dbReference type="HOGENOM" id="CLU_026314_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008688">
        <property type="term" value="F:3-(3-hydroxyphenyl)propionate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019622">
        <property type="term" value="P:3-(3-hydroxy)phenylpropionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF3">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="320"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCT75087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="640" mass="72151" checksum="496E82D68FAB337A" modified="2013-09-18" version="1">MVDDDLQETTDIIICGCGPTGAMLSVLLSQYSIPHVILEKDMEVNADPRGIALDEDGIRYLQACGIYDTIFTEIGQCMENFRFIGKNYTELNREPFLIMNYGTTEGGTGHPGFMCHKQPCIEQNLRSQITALGTAKLRLGSTVNSITEDKDWVYARYTNKSNQTGIVRARFLVGADGKTGFTRKQYLEPKGVTMDQALDVPYEQDWVALNWEISLPTPSSHPDFPLWEKGYTPQQVYDEFFPLDFRFLCNPVRAAVCGRFGLNSDRLWRFEFVVLVGENPIEMAKEDQVAAIVHPYITHLGSRYGINDKRITYPLDCIKVLRCRPFRLSARSCNKWSLGRVVLCGDAAHVFPPFGGQGIASGFRDAISLAWRLRIAVDGSSRPNVLDFQKLLQGWYSERKKQLDKSLRSTVENGEYVTQSNTFKAFLRDCYFYLAQLVPSWKHWLQLGNRRDGMTKYQWKPGTGMAFLPSLGGGVMFPQVYAASTTHSLTRQPVFFTDDIIFDRQKKGIFQVVVIMQLGGSIDDIEAALDGLQELSAGALQDREATWFLDSTDSPPSHLKGPSIYRLASAEEFAREPRLCAGRPEPVGYDALRMSKEVGEKTFVILRPDRFVFAACDTRSELLYAAEMLRDLVTTGWVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENH5</accession>
    <name>S0ENH5_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_09832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679031">
        <property type="protein sequence ID" value="CCT74108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436186.1">
        <property type="nucleotide sequence ID" value="XM_023568222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENH5"/>
    <dbReference type="STRING" id="1279085.S0ENH5"/>
    <dbReference type="GeneID" id="35403299"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_09832"/>
    <dbReference type="HOGENOM" id="CLU_533208_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT74108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="635" mass="71245" checksum="7E56D9C2ACF8DEF8" modified="2013-09-18" version="1">MPRVKVLRSGREILVPDQPSQEDTSSAATALGTLSNNGIESDEEERSVTPAPVDAGNGANVDFPDLAQHMLGTIQDIVRDMGLDKGSTTYKAFAMDNIADGTYKGKLSSFLAKNHPEPERSLVPVGAFASNNERSTWDTHCPKIDGLWGKYVQSVEPLLGDDYDLSWLCKPSGPLVARLLVLWHYPTINTPNKTFSHSMDQGNPSLRSQKYKIGLPDDVRTQDVNPIRVPYSHGVKPEWEKQFNNWDQIERLNYKFTVATCLDVPFVLVLGKQPFEVLKLAHRSRQWTLQALDIKLKAEHQMFQQPLRVYLSVSPGGNVKQVVIRCFHAEYAFYTPKLVHGAMMDFMWNLACEIAGVSVHNSTYFSFKVNSNSGRIFDSAKSEMKINATSMLHQLWKRELESDRQITMEEVEIYFASKIAAVPGLRQSIEDCAQQGESLLSPMWKLSRDRGAETLRDRNQKRNQLLPPPKAPARKRLKNENNDGGQSKKASHSWQMSTAGQAALAGQAKGRQTIANRMEAKYQALLNLHQIRQLEIARVSGTLTGSQSQAMTRLNAIKRYHDSDDRNNLTNSLARYTIFYHPIKYPRGVRFEGDGGPPQEVDPYANQDHPACVILLGSRLLRTSEQKNALAGPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S0ENM0</accession>
    <name>S0ENM0_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_10255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436291.1">
        <property type="nucleotide sequence ID" value="XM_023569017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0ENM0"/>
    <dbReference type="GeneID" id="35403720"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10255"/>
    <dbReference type="HOGENOM" id="CLU_059581_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004496194" description="Cytochrome b561 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT74213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41963" checksum="DA0E638F97023935" modified="2013-09-18" version="1">MTSRIQQLFLLACSVPILLSGQANSVAAHDLDYVNGETGLSIESLSRSRELNEPRSDEESRRQYCFGTTQNQVYVTDFLQHNLDILTGHSTCWLNRGIAGLRTELERNLTSTRRSDMQVPKCPINITSSGNTYLIDFPKNSYHVNTLSKSLLIILTSIHMAAMTLAFFIVYPIILIFSTLIALGELIERPLFKARIEKWQKILFCVLFLPLLAIGILCGLTGMGSSDHFRTEHGIIGLVTAVLATLAVGVYLIENNLRPRISISRRWRRVHMMVNYTDIFICQAVLMLSGFALPDGIDDFQVMSLCGTRHISTSLSFSVGMMVAFVWNSAMAAMTLQWWLVRRASEDKPPGKMWLLVSRIFRRNTNTCEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S0EP34</accession>
    <name>S0EP34_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_10671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679032">
        <property type="protein sequence ID" value="CCT74613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023436691.1">
        <property type="nucleotide sequence ID" value="XM_023569481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0EP34"/>
    <dbReference type="STRING" id="1279085.S0EP34"/>
    <dbReference type="GeneID" id="35404135"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_10671"/>
    <dbReference type="HOGENOM" id="CLU_017518_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT74613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="532" mass="59284" checksum="CA4DFA7820DBC329" modified="2013-09-18" version="1">MTSQADPATAEARVSKDLHDEPAKQDVSAGIIVPALAEGDMPDTTKKEIWSWYAYYIGSNGLALFNFGPTAFQNLLSQAAPKDTGLLPFAGRERDVNSIVLLANGISFAIQAVLFLIIGAYADFGTGRRWILLVWSIIAYGIGFAWLGVHDPSKWQTGTALYIVGLIAYQMTLTYWTAAFPSLARNTPQLKEAAFQFEAGEITQSEMDRKDEMERSRLSNVAFYIQSVGEVVILAIIVGIMFGVKVDKSAENNNWGLSVLIAFATACWLVLSIPWFVLEKKRPGMKVPDHLNMITVGFWQLWEALTQIWHLKQSLIYLVGYFLLGDSLNTTVTVIGTLQNQVVSYETLTLTYLLIVGIVAQAIGIGAFWLIQKHFNLSVKAMFNAVMVFIILLDGWGMIGNWTDKFGFKNVWEIWLYQAFYGLFVCPWYSYSQIMISSVTPRGHEFLFFSLFNIIGKSSSFIGPFISSAIIDATPGGTNNSAPFYFLFALSLVSAIGIWSFLDLEKSAREQELFIIQEKIRMGEESEASNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>S0DHY6</accession>
    <name>S0DHY6_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423712.1">
        <property type="nucleotide sequence ID" value="XM_023572418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DHY6"/>
    <dbReference type="GeneID" id="35395431"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01948"/>
    <dbReference type="HOGENOM" id="CLU_2740079_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT61631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="72" mass="7838" checksum="ADF6DA012CCF4E95" modified="2013-09-18" version="1">MSNPTYKNANVSETTLVDTTKPSTSTKPGLETAPHKPSLKEKIQRKLAGSVDPTKKPADPYKSWEARSVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S0DI04</accession>
    <name>S0DI04_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_01857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423747.1">
        <property type="nucleotide sequence ID" value="XM_023574062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DI04"/>
    <dbReference type="STRING" id="1279085.S0DI04"/>
    <dbReference type="GeneID" id="35395340"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01857"/>
    <dbReference type="HOGENOM" id="CLU_111212_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT61666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="216" mass="25654" checksum="6B79F0FA3E1C4D6C" modified="2013-09-18" version="1">MAQIQDMSSRWIYEDGPELSKTKNNPDSFFLNLPVEILLIIHSFLPASSQLCLLTTCRGIKILLEYRTVSYSRLTLEQKKEYKTFVIRQFPNAWLDEKTLRFREFQEEDLYPQPQGPPVRYQPGWKFNDIINFKRGALLIRHRHVRMSLIYHQLEKKTRQQMSFLKSLLEPYHTDFSPCHNIHPSEKSGVVGHFEPHPKLVSGRYLLFNKWTFTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJ16</accession>
    <name>S0DJ16_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Related to transcription initiation factor TFIID subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_01182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424361.1">
        <property type="nucleotide sequence ID" value="XM_023581584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJ16"/>
    <dbReference type="STRING" id="1279085.S0DJ16"/>
    <dbReference type="GeneID" id="35394667"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01182"/>
    <dbReference type="HOGENOM" id="CLU_016434_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="156"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT62280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="493" mass="54320" checksum="25734032C077F363" modified="2013-09-18" version="1">MSTPTPKDGQPPAKPRLKLNVSRSSSFVADANATPSVSVPAGPAAPTPTPTEGSRKVKLKIGKSQPSTPAEQPPVKTKAGRQPKPTQKLVESKKRAHDELDDELGSAHPTTKIKLKPTKSGLTPTVVVKPKGRAPVHPPGDGYDSEASDREKDPSIEEQFVLRMLPGEHCDYVRSCMENGKMGVPRSQGGADIQLRFFEEDSRRAVVSVKGQPFAAVMVDLPTVTEAMKTWDRKSFLKSADICQMLLVYQKVSNEAEARQTPLPSMIDQHFKWPHGLTPPMHDCVNRRFAKTISRKEIEDKEAEVERLLAEDAKAGSTRWEWVDESKDEDEDGGDEDAEGDMDDDGMDYFQSQDVFGDGDDDLAADLEAAFGEMGDETPATGMDAPTPMTTTQANTPAPLQDSIESDESEEVSDDDDDDDDDEDLDEDARAQRDEEKGVKSFINDLKNQLTSKQEELARTTNKILRTRIEQTIKQLRAEIELKNSSIGIETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJU1</accession>
    <name>S0DJU1_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to SRO77-polarized exocytosis by regulating SNARE function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_00849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424667.1">
        <property type="nucleotide sequence ID" value="XM_023570485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJU1"/>
    <dbReference type="STRING" id="1279085.S0DJU1"/>
    <dbReference type="GeneID" id="35394334"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00849"/>
    <dbReference type="HOGENOM" id="CLU_006030_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="5">
        <location>
            <begin position="517"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="896"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="910"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT62586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="992" mass="108167" checksum="140F0A984B38D7F9" modified="2013-09-18" version="1">MAAFLRGKQTGMQNDLSASIRPELFMPDDQARYGINSQIRYRSVSPNICYAYDPVQSLLAIGTGESKFGPGKVYIFGQRRVHKILEPPRRTSFQIVQFSANRLVTVDAKNELGIWDLDTGERIAALVVAGQVVSLVTDPMLDWAFIGLYNGDIMAFDLDRGSLARSFRLPNFWKEKNPGATTPNLITMSLHPRDVGKLLLGYTHGAVVYSFKQAKPVNYYEYAVPAGAPGGNGAAVETVRKPRLTHALWHPSGTFILTAHDDGSLVFWDPKAEKIVMARTLTDFNVDQPSPETPTPALPEPITKIAWCCKENCDDSGLLIAGGQRPDASPKGLTFIDLSQTPVYATSTWQILANYCRGKRQNVLPLPSGAQAINFLLIPRFSPHFAGAQDPIAVMVLLSSGELITLSFPSGYPISPTNQLHPSVSFVHPFVTKVNVSSLERPRWLSMFEKRNQGEPLLKGGAEASRPRKRFEERTIIQAAHADSTIRIWDSGHADEIENGTQLQVDVARALDRYDDVEITCMNMATSTGEFVVGTRTGEAIIYRWGQNRFFGKDKALQLDPNPKGLTDISSRAEPGLKEGLQPLVLYEMMMGPITAIQVSNVGFVAVGSELGFLTLIDLRGPTIFFQAPMTDFAKPDKRSSFLKSHSSSPGPQKEWPVVIEFGVMTLDEDKYSSICCFVGTNLGKVITFKLLPGQDGTYSASLAGVVSFDGKIISLNPIEADTGKPAHATGPIVAGLREGRQVNGVLVAVTQTEIRIFKPANSKGASKEFDSILCDSACVAELELQGFAVVGVFGDRTARAFSIPGLRDIGKADLPMIDVTRSTNSVVTQTGDVFAWTGPSELAVIHVWGTGKGPQQSPDTLINPKLECPPRPTISNMQWISGSQYISPTDLDLLVGGPDRPPSKRMMDAAAAEQRAARAGESAAASGSGSQEGWGDYLTRQLNERTEKLNMMGDNMENLQNNSAGWADDVNKFLNKQKRNVVMGGLKSKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S0DJX8</accession>
    <name>S0DJX8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFUJ_00738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424766.1">
        <property type="nucleotide sequence ID" value="XM_023571718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DJX8"/>
    <dbReference type="GeneID" id="35394223"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00738"/>
    <dbReference type="HOGENOM" id="CLU_075634_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCT62685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="255" mass="28657" checksum="A1BF4B4BF74252BC" modified="2013-09-18" version="1">MITSEVNGLDLLDLPVDILSIILKPLVTSATPICLCPCTKSTVDPLPILLSHPALHTIATPLLYAGNEFLLDASGPHAQHIRRELQRAPRGADDRLPGRATLLTTRGALRRIARLEVRIDRLRGWIGTDIIPLLTELAVQGRMDYLAVWVRTPIEPRTPVHFRPAKPGKDLDMFARPPLEGLLRVLADPYLLSARLWVDARHAKTWCRFHAGECGAESGDPGRERERVEIDWREIIRVVDPDRKEITVIGTEKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DK73</accession>
    <name>S0DK73_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Related to transport protein USO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424886.1">
        <property type="nucleotide sequence ID" value="XM_023573107.1"/>
    </dbReference>
    <dbReference type="STRING" id="1279085.S0DK73"/>
    <dbReference type="GeneID" id="35394090"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00605"/>
    <dbReference type="HOGENOM" id="CLU_000589_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2156"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2220"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2059"/>
            <end position="2135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2220"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2251"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2277"/>
            <end position="2295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2296"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2319"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2338"/>
            <end position="2349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2350"/>
            <end position="2360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="2368" mass="261157" checksum="2C9B5723AEDF6A42" modified="2013-09-18" version="1">MSSSERDSFYDGDFQLRHQQSASSDPNLRALVPMWDSSDPERCPPPLPLNPGSPLTSRVGTSSAIASAHAALNERARESTMVPTKRIESPTKGHRRLQSSVRDISMMIEGASGHSSPSRSPERQQRPETPSRSRDVDNRPNEKDSVVSSTTPVPGPSLTPILRPAVRRPPPQSILGENTPPQSSTMLALQHMTSSTPVKEPENPLTDITNGSLTLSKGPQNLEALSDQILSLTSIATGLQKEMSQLSRRSRDNATDLLSLKEATNSRDEDIRKSLRELLGSHGNGNDGHNRLPPARDPFGGYYLDNKPHNLSPPSTRGFHLPRIPSPKSFGDSIERGSISTPSLAGSEAPPSVILLERIIREMGTKEGQESLLGRLQEVSNKLSGMATSQKLDEVIEQVKAQSEQAIILGNSLGSPHASRSRNLSFESENSRSDTMPGQARSAVSQRVEHIMRNEARRNSEPSARGAEILNDDLISIIRSVKDSVSQGGGLTAEVKALVRELRGEVLGMGREIGRRLEQQASRRGVEDHDTPSKDEVARVIDEGLEQMKDQLNHVLREHRRQSAASVNTQKSAVDYQEIYNAMRAAIQDNEATKSNLPDLSREDVIEAVRDAWENYKPEIEVQQLGLERDEVLACLKQGLQEYAPRDDQPPAVTRDEVFTAVVDGLKHFVPPQVDQPATLSREEIIDAVRDCLEEFEFPVAPGAGNDMTHEDVVHAVREGLQDLDVHSSRALVPASASNDDVADRLREIMEFLRHEFKTLSEETKETVAANGRETEQVRDVTKDGFENLRQAMESYVDRATGAAGQEEFMDDLLKSLEDFKDEMAGIVSTTNQESREQLQTELEGLREIVNSSMVPALPPQTNNTEVLEALNTGFNNLRQEVLRPRAETSEILDALNDGLNDLRAGMDRVTNKPTDLTANDEILEALKTGLDSVRADIESIRNSSNDRAVATLESTPPANDEVLEALKSGLSGVRTDIEALRDSQTEKAVAVVEPKENDEVLEALKNGLDALRVDIEAIRLSTSEKLAAPVDNTTNDEVIEALKNGLDSLRVDIEAVRDSSEKAIAPVDNSSSTEFIEALKNGLESLKADIELSRENSDRAALGEDTSNDEVIVTLKNGLDSLHAEIAALAAQEKPDAPIENTSNDEVIVTLKNGLDSLHAEIVAIATVQKEAAAPVDNTTNDEVIEALKNGLDSLRTDIEGLQESNQKALAPVPDTKPNDEVLDALRTGLESLRSDIETLRESNNERAIAPAESATDEKILDALKTGLESVRSDIEALRDSNGERALAAVSTEKTEDDGPSEKIKSDDIKNLEVLIAGLAIKIDSVKSENEGVQKDDLSRMEDLLRTVQDSVDEIASRETLTRSASVKKKKEDGEEVTARAIVGDGDEPASKEDMQAIETILRNTKGQLDDLIDGEQAVRKDHIDNVEALLLETRETMGSLTTQLETVSRKEEVTALEALLGQVSTRLDEMKEHATKESENPDKVTKADVEAVEALALEVKTALESFTSTDLALLARKEDITSLEALLVKKEDLTGLESIVKDFQDKLDTTVDAQTKAIAVRDEESTSVGERVTEVKTFLEELQGTINVKLEEGATGVESISKLLETVGEKINKNENVHQDLKDMLDTIKTEFEDSKAVVSGVKVESNEKLQEATETLSTKIDEKIGELIAKYETLQTTLDDRSKVSEARDEAMEAAVVSSKSVTDELKLLIDTLGSTVTDSLEKMEEASKTVFTKVEELVARSEETHTEDKAEHQQTRDQITEALTAVESLKGEVSESHPKILESVKDLLLLVGEHYEHSKSSTTEIQDKIVEHKSPEELMTLLTLLTDDKFHNTHVHEKLDKLIEQIYNDSEVKERLDKIIEEKYNDTEVREKLDKIIDEKYDDSQVHQKLATIIESKYDDSEIREKLEKIIESKYDDAEVRSKLDKIIEEKYDDAPIKEILGMLVEQKYDDTPVREKLDLIMDSKYDDTLVREKLDLVLDGRYDDAVVQEKLDKLVDHSAVADQAFSRLDTLDKVHASVVQTAADISEFLSVQKQRIEQAHEDHTKTLQETMASVERKLAEKDHVEAAVASLRDEEERLRQSVMTLRTEQESLIRQKTRLTGDVSSLETALHMRKEELYDMESRAENLERRILEGVMDHSRVLLMAKANRNGGDAMSRKRVRKPANEEESPEAGAHGRKSMVGMALNAKRNLAAPVQNGAGRRIVSLSQINNNVASGGVKRSQSVRTPLGGGKTYRKRSWGGNLDKGLADNDKENTLNETVEEVDEADVKSATAPEVTETPTDETIIIESTPNDEEADGGEGGDSDNETLRRSSRGTVVTNSTDMYTDGDEGSEYSYTESEWTESNVGTDAGSVQGNEVVVYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKB5</accession>
    <name>S0DKB5_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_01718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423873.1">
        <property type="nucleotide sequence ID" value="XM_023575595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKB5"/>
    <dbReference type="STRING" id="1279085.S0DKB5"/>
    <dbReference type="GeneID" id="35395203"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01718"/>
    <dbReference type="HOGENOM" id="CLU_026885_0_1_1"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCT61792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="471" mass="52541" checksum="437C07CD9CE3E9F1" modified="2013-09-18" version="1">MASSSSAGWEPSSWRSKPIKQSPNYPDAEPLAKAVEELTQLPPLVHPNEIIALKAHLRDVAQGNAFLLQGGDCAELFDYCRQGPIESKIKLLLQMSVVLIWGTNKRVVRIGRMAGQYAKPRSSPTEMVDGKEVPSFKGDIINGFRLEDREIDPNRLVKAYHHSAATLNYIRAALASGIADLHRPLDWGLGHVRDPELKEKYSAIASSIQQTLRFLQVINARPGELDSVELFTSHEGLLLDYEQSLTRLLEKPTARTSSPTPVADDGEKKEYYDTSAHFIWIGDRTRQIDHAHVEFFRGIANPIGIKVGPTTPASDLLSLLRTLNPSREPGKITLITRYGAAKVRDLLPMHIRAVEDSEYRRTVVWQCDPMHGNTLSTPTGIKTRRFGDIYRELEETLRIHKEEGSNLGGMHLELTGDAVTECLGGSEGLDEDDLSTNYTSFCDPRLNEKQALELAFLVADHFSRENKARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DKM9</accession>
    <name>S0DKM9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable 3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFUJ_00419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425056.1">
        <property type="nucleotide sequence ID" value="XM_023573314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DKM9"/>
    <dbReference type="STRING" id="1279085.S0DKM9"/>
    <dbReference type="GeneID" id="35393904"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00419"/>
    <dbReference type="HOGENOM" id="CLU_010194_42_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCT62975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="262" mass="27791" checksum="F70A8BB7E82FC26A" modified="2013-09-18" version="1">MKIQDRTFVISGGASGLGQACVEDICANGGNVAILDMNEENGQELVKKLGSSAKFFECNVLETESVTKAVQGAAQWAKETGKPLGGVIAAAGVSTPATMLDRNGAAFSLDDFDFVINVNLRGTIDLVRQTLEHLAKVEPEGSDGERGVVIMVASSAAFDGQKGQVSYSASKGAVTAMTLPMARDLARYGIRVVTIAPSLFDSRMTSVMPEKVKKSLEGAMEFPKRAGQPKEFAQLARQGIENVMLNGVVIRLDGAMRMPSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>S0DL54</accession>
    <name>S0DL54_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Related to DUF962 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_01411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424153.1">
        <property type="nucleotide sequence ID" value="XM_023579017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DL54"/>
    <dbReference type="GeneID" id="35394896"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01411"/>
    <dbReference type="HOGENOM" id="CLU_081702_1_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCT62072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="188" mass="21144" checksum="88948ECBF0B04B35" modified="2013-09-18" version="1">MSLDLEQHLTFYGAYHHNSVNVAIHMVCVPLILLSGFCMATYTGTLIPTPSWITPPYLDLNLGVIGASLYSLLYLLLEPFAGFLLALFCMGGVALGNYFHQQNPDTTFQGALAIHVVCWIFQFIGHGKYEGRAPALLDNLIQAVFLAPMFVWLEILFKFGYRPELRSRVNKKVQVEIEKFRSKNGKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLC0</accession>
    <name>S0DLC0_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Related to hexose transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFUJ_00165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT63211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023425292.1">
        <property type="nucleotide sequence ID" value="XM_023573598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLC0"/>
    <dbReference type="GeneID" id="35393650"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00165"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="28"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCT63211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="499" mass="54909" checksum="DE9A3048C99FB14A" modified="2013-09-18" version="1">MGNVAEVGHGPSHQPWWKTSHLIKLNSIILSLVLFSSANGYDGGLMGSILALNTWNTFMHHPTGAYLGWMTAIYWLGNGLSTPLAAWCSNRYGRKPGLYAGYFFLIIGVGMQAGAPNEKAFTYARLFIGFAAGFLGNSAPVLINEIAYPSHRSIASALFMCGWYVGGTICGWVTFACRVIPNDWSWRIPVLLQIFLPLCALPGFLMAPESPRWYVSVGRLEEATDVIARYHAGGNRDDPIVSTQMMEIEAAITAEKDASKSASYLDMFKTKGNRHRLFISVTLGFVAQWAGNGVVSYYLPLVLTSVGLKTTTEQTLISACLNVWNLLWATAAAVSVDRLGRRFLFLTSATVMFLSFVVVTALSASFAKSGASSVGLAVVPFLFLFFAGYDVGLTPFLVAYPCEIWQFSLRSRGLTVAWCTTVASIFFNSFVNAIALDAIQWRYYIVFAVILFIFIFVVYFTYPETRGHTLEQMAVIFDGEDAVPSQAVALEKTDVEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>S0DLK9</accession>
    <name>S0DLK9_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable mitochondrial amino acid transporter ARG-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFUJ_01213</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424333.1">
        <property type="nucleotide sequence ID" value="XM_023581239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DLK9"/>
    <dbReference type="STRING" id="1279085.S0DLK9"/>
    <dbReference type="GeneID" id="35394698"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01213"/>
    <dbReference type="HOGENOM" id="CLU_015166_16_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="127"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="240"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCT62252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="331" mass="36463" checksum="2C7BF3352B9F7EB2" modified="2013-09-18" version="1">MEPSPVAVEVVSHAPNFSLKEKTALMEAFEDVLCGSFAGAVGKYIEYPFDTVKVRLQSQPDHLPLRYSGPLDCFRQSIKSDGVLGLYRGITAPLVGAAAETSSLFLFESLGRELLFTSSLVSREQGLSLPYLWLTGAFSGAFTSFVLTPIELVKCRIQAPMSADGSAGPPLRPIPVIKQVFRHEGLLGFWHGQLGTLIREAGGGSAWFGAKETVTSMFYQLKTKTAKSATEKQIILDTPLPFWQQAIAGASAGVSYNFLFFPADTIKSRMQTSTVSDLRQRRTFWKEGAMLWKQHGIRGMYRGCGITCLRSAPSSAFIFMVYDGMKRHFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>S0DM17</accession>
    <name>S0DM17_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Related to epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFUJ_01950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT61568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023423649.1">
        <property type="nucleotide sequence ID" value="XM_023572196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DM17"/>
    <dbReference type="STRING" id="1279085.S0DM17"/>
    <dbReference type="GeneID" id="35395433"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01950"/>
    <dbReference type="HOGENOM" id="CLU_020336_7_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCT61568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="327" mass="37510" checksum="1B2A151F13A2A007" modified="2013-09-18" version="1">MALELPTRQTFTARSGNVYSYVFTPPTSESTTLLFLHGFPSTLTDWIHQIQHFSSQGYGIVAPDLLGYGESSKPTDVNAYRLKPMSDEVIQLLDHLDLKTLVGIGHDFGATLLSRMAAYYPSRWEALVFLAVGPPKLGTPFDVDMINTMTKQFLGYEMLGYIPWLADYRSQEILEKNAEATMSLIFCRNREEWETWFHPLGKMGEFVCEDRRLPIASWYTEDLQKAHLKAFGSADGYKGVCRWYRMWRDNLFAPDEQGYEDFRISQPVLFIVPSEPEQSASQQQQMVSSWAPHLQTVKLNTSHWIHIQAPTETNTTIQNFLASRRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNB8</accession>
    <name>S0DNB8_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable NADPH oxidase heavy chain subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424983.1">
        <property type="nucleotide sequence ID" value="XM_023573225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNB8"/>
    <dbReference type="STRING" id="1279085.S0DNB8"/>
    <dbReference type="GeneID" id="35393983"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00498"/>
    <dbReference type="HOGENOM" id="CLU_005646_3_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000029">
        <property type="entry name" value="NADPH oxidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="244"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT62902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="557" mass="64264" checksum="85BD0A0FAADA0A7F" modified="2013-09-18" version="1">MGSHIGFLELIKKQFTASKLFFHFLFWTFHWGIFAYGWWKQAADARLAGLNTLKFSVWISRGAGLVLSVDCMLILLPVCRTIMRWVRPKIRFIPLDENLWMHRQLAYSILLFTCLHTGAHYVNFYNVELTQIRPVLALQIHYAQPGGITGHVMLLCMLLMYTTAHARIRQQSFETFWYTHHLFIPFFLGLYTHTVGCFVRDTPEAISPFAGDEFWEHCIGYLGWRWELWTGGFYLLERLWREVRARRETKITRVVRHPYDVVEIQFNKPSFKYKAGQWLFLQVPGLSKYQWHPFTITSCPFDPYVSVHVRQVGDFTRELGDALGAGAAQAKLYDDVDPMGMYEVALQNGDQMPALRIDGPYGAPAEDVFENEIAVLIGTGIGVTPWASILKNIWHLRNSPNPPRRLRRVEFIWVCKDTGSFEWFQTLLSSLEEQSNEAARMPGSSGVEFLKIHTYLTQKLDIDTAQNIVLNSVGAQMDPLTELQSRTNFGRPDFPRLFTTMRNGILDRTYLNGLESHIRTTVGVYFCGPSSAARDIKTACKAATVPDVEFRFWKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>S0DNV4</accession>
    <name>S0DNV4_GIBF5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Related to large-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFUJ_04526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679024">
        <property type="protein sequence ID" value="CCT64269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023426350.1">
        <property type="nucleotide sequence ID" value="XM_023572177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DNV4"/>
    <dbReference type="STRING" id="1279085.S0DNV4"/>
    <dbReference type="GeneID" id="35398007"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_04526"/>
    <dbReference type="HOGENOM" id="CLU_095787_2_0_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.120:FF:000004">
        <property type="entry name" value="Ion channel, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="entry name" value="Large-conductance mechanosensitive channel, MscL, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266:SF2">
        <property type="entry name" value="LARGE-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="MECHANOSENSITIVE CHANNEL MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="Gated mechanosensitive channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCT64269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="183" mass="20535" checksum="2A199D816889C6BB" modified="2013-09-18" version="1">MPGRSHDEESGSGESESLLGRGHKRVKRFWEGFVDFAFQDDILKIAVGLILAAAFTDLVKSFVSDVLMPPISILLPLNRNMEEKFAVLQKGPNYNKTTGYNTLHQAQDDGAVVLAYGSFVGQMISFLVLGIALYGLAHLWQLASSEPIIKHTKKCKYCRQRINEKSIRCIQCTSWLDGREDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>S0DP21</accession>
    <name>S0DP21_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">FFUJ_01131</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424409.1">
        <property type="nucleotide sequence ID" value="XM_023582150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DP21"/>
    <dbReference type="STRING" id="1279085.S0DP21"/>
    <dbReference type="GeneID" id="35394616"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_01131"/>
    <dbReference type="HOGENOM" id="CLU_008438_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097586">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900101">
        <property type="term" value="P:regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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            <end position="71"/>
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    </feature>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="770" mass="88328" checksum="FE63A34B655B9BA8" modified="2013-09-18" version="1">MARSSTPQGSLRQRGAPSKKPSEEDSFDPNIELDKLAKAGAQRAAAQSETEYKIGLFLITILSFVTRFWGISHPNEVVFDEVHFGKFASYYLERTYFFDVHPPFGKLLFAFVGWLVGYDGNFHFENIGDSYIANKVPYVAYRALPATLGALTVSVTYLIMWESGYSLPACILAAGLVLLDNAHIGQTRLILLDATLVLAMACSLLFYIKWYKLRHEPFSRKWWKWLILTGFALSCDISVKYVGVFAFVTIGSAVVIDLWDLLNINRPGGAISLQEFTKHFAARAFGLIIMPFLFYLFWFQVHFAVLYRSGPGDDFMTPEFQETLSDNVMLANSIDIQYYDQITIRHKETKTYLHSHEDRYPLRYDDGRVSSQGQQITGYPYNDTNNYWEILPANNDKQMGRIVKNHELVRLRHVGTDKILLSHDVASPYYPTNQEFTAVTPEEAFGKREKDTLFEVRIEHGKKNQNFKTVAGHFKLIHNPSKVAMWTHTKPLPEWGYKQQEINGNKQIAPSSNVWIAEDIPSLTADHPRRQKPERKVKSLPFLQKWFELQRAMFYHNSKLTSSHPYASHPYQWPFLLRGVSFWTQSETRQQIYFLGNPIGWWLASSLLAVYAGILLADQVSLRRGVDALDRRTRSRLYNSTGFFFLAWATHYFPFFLMGRQLFLHHYLPAHLASCLVAGALLEFIFNSEAPEEVTIKDKKGPVSPRHHVTARERFAGQSMLGAWIACGAILSLIVAGWYFFLPLTYGYPGLSVDAILRRKWLGYDLHFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S0DPN5</accession>
    <name>S0DPN5_GIBF5</name>
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        <recommendedName>
            <fullName evidence="4">Endo-1,3(4)-beta-glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFUJ_04374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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    </feature>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCT64406.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="44980" checksum="0C9058E72CE81BE5" modified="2013-09-18" version="1">MNSQPNGAGPAQSRESYKHSMEEWRQSALAQRNQYEPRVKEQVTRYFQEYSPPFYASVIGYRRDWNLLVATSRVSGFAATLGRDLEDVEAKAIAEYTLDNIHTNAGLKWLSVALAGYMTYRGRRTWQFPFYKPKLGGRFNPNEATSIFTNKKIRGAYPRATWHCLRFTAYAAVIMLMIEPAFRAVSFIRTEAAMTNDPRLKQFTKDAAERVKDVMSNPTISRAPFTGRDVHKSDDNDPWASNDSSNTSSESRYQPTPTQSWDKAQSSTTTQQSQRPNDDWSVLDDDDDASPIASSSRNKPPSPPAGSAWERIRQQSQGPPQQSDYQSRAWAARSQTGSQPESQSGWGSRSAGSSSDSFSFSKSDEERAVAKEQAQDEFDRLVERERKGVDQEKAWGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ53</accession>
    <name>S0DQ53_GIBF5</name>
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        <submittedName>
            <fullName evidence="10">Related to small nucleolar ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFUJ_00712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_023572007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ53"/>
    <dbReference type="STRING" id="1279085.S0DQ53"/>
    <dbReference type="GeneID" id="35394197"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00712"/>
    <dbReference type="HOGENOM" id="CLU_005417_0_1_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="361"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCT62708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016800"/>
        </source>
    </evidence>
    <sequence length="962" mass="104223" checksum="FE1EBA2AB24550C7" modified="2013-09-18" version="1">MAGHKSPRTKNDPTKKRKRDVTETDSRTKRLRAERKANKINGIKLENESGNGVVAEVNGISGALAEAGTREIEIVRQFDDTEAGWRVSKPMGGRILDIDPILTENEQFLIIAYNTSIQVYSAADSLLVRRIPVTAAEPADNKAAAPAHIVAMRQAKQNSNIVWVATSDGRICEVDWTTSKTPEFFQTQSKTATAMALVTKKVSGRVQEIIFVAESDKPGRIEVVAYPASTTESGHKVLFVMKKPGNGLQLLETSEDGHLVGAINDRLFFGLPSQRQFDNLAALDYEIYTFDIPDLVSALDLRVYPRPVTSGKKSRQEAAPVLDIIVGGARGSIYLYHDALARSQALAKSGSDKELIQAQNFHWHRRAVHALKWSRDGNYVISGGSENSLVLWQMDTGKKDFLPHLSGSVENITVSANGSSYVVHLDDNSVMVISTAEMKPTAYIAGIQSAAINVTTPKDLLVQRTWTTPASVQRPIPAAISPTDQSRLHVCVGSGRQATMSGGFSAPLLQTFDLETFRSVSKQALARTQPTDVNITNKGHPIEEPVISHLAFTADGAWLASVDTWEPSQRDVDNVISDAKDQFIQERREVYLKFWEAQEGEEQIALVSRINAPHATNRNEAVLDLASNPVSTCFATIGTDGNVRLWRPKTRSQNGVVVKGPNGREVFTWSCSQIIAVGDGIPQDGVIDLPESGVAQEPQGSIAFSEDGSTLFVAFGTGASGVIYLIDAASGDVVKTLEGQWKGQLRSIRALSPFVIILSDELRVYDVVSDELRYGVVIPQSKANALLQLAVDNTSGHFALALPANEGSLIAVFQPEDIEPLLVRSTPQRIVSLVSAPETSGFIALDDAAQVWVVAEGSDPSSLATVQPLEDLRLEGIDANGNEAGLLDEDEDMASDVDDAEVEPVTEPEDIEMGDDDSHPSVIQQQHLADIFDAAPAFAAPPIEDLFYKVTGLLATKPLSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>S0DQ64</accession>
    <name>S0DQ64_GIBF5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFUJ_00700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)</name>
        <name type="common">Bakanae and foot rot disease fungus</name>
        <name type="synonym">Fusarium fujikuroi</name>
        <dbReference type="NCBI Taxonomy" id="1279085"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Nectriaceae</taxon>
            <taxon>Fusarium</taxon>
            <taxon>Fusarium fujikuroi species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003475" last="E1003475">
            <title>Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.</title>
            <authorList>
                <person name="Wiemann P."/>
                <person name="Sieber C.M."/>
                <person name="von Bargen K.W."/>
                <person name="Studt L."/>
                <person name="Niehaus E.M."/>
                <person name="Espino J.J."/>
                <person name="Huss K."/>
                <person name="Michielse C.B."/>
                <person name="Albermann S."/>
                <person name="Wagner D."/>
                <person name="Bergner S.V."/>
                <person name="Connolly L.R."/>
                <person name="Fischer A."/>
                <person name="Reuter G."/>
                <person name="Kleigrewe K."/>
                <person name="Bald T."/>
                <person name="Wingfield B.D."/>
                <person name="Ophir R."/>
                <person name="Freeman S."/>
                <person name="Hippler M."/>
                <person name="Smith K.M."/>
                <person name="Brown D.W."/>
                <person name="Proctor R.H."/>
                <person name="Munsterkotter M."/>
                <person name="Freitag M."/>
                <person name="Humpf H.U."/>
                <person name="Guldener U."/>
                <person name="Tudzynski B."/>
            </authorList>
            <dbReference type="PubMed" id="23825955"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003475"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 195.34 / IMI 58289 / NRRL A-6831</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="HF679023">
        <property type="protein sequence ID" value="CCT62718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023424799.1">
        <property type="nucleotide sequence ID" value="XM_023572140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S0DQ64"/>
    <dbReference type="STRING" id="1279085.S0DQ64"/>
    <dbReference type="GeneID" id="35394185"/>
    <dbReference type="VEuPathDB" id="FungiDB:FFUJ_00700"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="Proteomes" id="UP000016800">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000035">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference t
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